ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05224	Breast cancer	23/669	147/8144	0.00191	0.6245	0.6245	DVL2/CSNK1A1/WNT8B/CDK4/GRB2/FZD1/PTEN/HES5/FZD2/KIT/FZD9/BRAF/NOTCH2/SHC4/FZD3/WNT9B/HEY2/ESR1/FOS/IGF1/FRAT2/AXIN1/MAPK3	23
KEGG	hsa04310	Wnt signaling pathway	23/669	167/8144	0.009494	0.6942	0.6942	SENP2/LGR5/CSNK2A1/DVL2/RAC3/CSNK1A1/WNT8B/RSPO4/RSPO3/FZD1/TBL1Y/CTNND2/FZD2/FOSL1/INVS/FZD9/FZD3/WNT9B/RAC1/WIF1/CSNK2A2/FRAT2/AXIN1	23
KEGG	hsa00910	Nitrogen metabolism	5/669	17/8144	0.009907	0.6942	0.6942	GLUD1/CA8/GLUL/CA5B/CA7	5
KEGG	hsa05225	Hepatocellular carcinoma	23/669	168/8144	0.01018	0.6942	0.6942	DVL2/CSNK1A1/ACTG1/WNT8B/CDK4/GRB2/FZD1/PTEN/ELK1/ARID1A/FZD2/TGFA/FZD9/BRAF/SHC4/NFE2L2/FZD3/WNT9B/MGST2/PBRM1/FRAT2/AXIN1/MAPK3	23
KEGG	hsa03250	Viral life cycle - HIV-1	11/669	63/8144	0.01267	0.6942	0.6942	CPSF7/RANBP2/CD4/APOBEC3D/BICD1/PSIP1/NUP153/SERINC3/CXCR4/BST2/TNPO3	11
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/669	143/8144	0.01274	0.6942	0.6942	DVL2/WNT8B/RIF1/GRB2/FZD1/PCGF2/BMPR2/NEUROG1/FZD2/PCGF6/FZD9/PCGF1/PCGF5/FZD3/WNT9B/KLF4/DUSP9/IGF1/AXIN1/MAPK3	20
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/669	26/8144	0.01667	0.7786	0.7786	PIGH/PIGA/PGAP1/PIGT/PIGN/PIGB	6
KEGG	hsa03460	Fanconi anemia pathway	9/669	54/8144	0.03036	0.8866	0.8866	ATR/FANCA/USP1/PMS2/REV1/MUS81/FANCB/PALB2/UBE2T	9
KEGG	hsa05217	Basal cell carcinoma	10/669	63/8144	0.03148	0.8866	0.8866	DVL2/WNT8B/FZD1/FZD2/FZD9/FZD3/WNT9B/BMP2/AXIN1/SMO	10
KEGG	hsa03040	Spliceosome	19/669	147/8144	0.0316	0.8866	0.8866	SNRNP40/PRPF18/RBM25/HSPA1L/SNRPD3/SYF2/PPIE/SF3B4/SNRPC/SNRPF/DHX8/SNRPG/THOC1/PRPF31/PHF5A/SNRPD2/MAGOHB/HSPA6/DDX46	19
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/669	30/8144	0.03253	0.8866	0.8866	SUCLG1/ACO2/OGDHL/MDH1/SUCLA2/DLD	6
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	6/669	30/8144	0.03253	0.8866	0.8866	GCSH/ACO2/MDH1/GLUL/ACSS1/DLD	6
KEGG	hsa04710	Circadian rhythm	6/669	31/8144	0.03764	0.9092	0.9092	PRKAG1/RORB/BHLHE41/PRKAB2/CLOCK/FBXL3	6
KEGG	hsa04510	Focal adhesion	24/669	201/8144	0.03981	0.9092	0.9092	RAC3/ACTG1/RAP1B/GRB2/MYL12A/PTEN/LAMA1/ELK1/RELN/COMP/BRAF/SHC4/COL4A4/MYL10/RAC1/IGF1/FN1/ITGA6/TLN1/KDR/COL4A3/THBS4/CAV2/MAPK3	24
KEGG	hsa04142	Lysosome	17/669	132/8144	0.04171	0.9092	0.9092	DMXL1/LAMP3/GNPTAB/CTSH/AP1M2/LGMN/MFSD8/MANBA/ATP6AP1/HEXA/SGSH/NAGPA/ACP2/GGA3/CLN5/CD164/NPC1	17
KEGG	hsa00510	N-Glycan biosynthesis	8/669	50/8144	0.04934	1	1	ALG9/ALG12/MOGS/ALG13/MAN1A2/ALG2/SRD5A3/DPM3	8
KEGG	hsa01522	Endocrine resistance	13/669	98/8144	0.05688	1	1	CDK4/GRB2/ADCY8/BRAF/NOTCH2/SHC4/GNAS/ESR1/FOS/IGF1/MMP9/MDM2/MAPK3	13
KEGG	hsa04914	Progesterone-mediated oocyte maturation	13/669	102/8144	0.07364	1	1	CCNA2/CDK1/ANAPC5/CDC23/SPDYE1/ADCY8/BUB1/BRAF/MAD2L2/PDE3B/IGF1/CCNA1/MAPK3	13
KEGG	hsa04150	mTOR signaling pathway	18/669	156/8144	0.0883	1	1	DEPDC5/DVL2/WNT8B/GRB2/FZD1/ATP6V1D/PTEN/FZD2/FZD9/BRAF/RRAGC/TSC1/FZD3/WNT9B/IGF1/SESN2/CHUK/MAPK3	18
KEGG	hsa00513	Various types of N-glycan biosynthesis	6/669	39/8144	0.0964	1	1	ALG9/ALG12/ALG13/MAN1A2/ALG2/HEXA	6
KEGG	hsa05165	Human papillomavirus infection	34/669	331/8144	0.1012	1	1	CCNA2/PPP2CA/DVL2/CSNK1A1/WNT8B/CDK4/GRB2/FZD1/ATP6V1D/ATR/PTEN/HES5/LAMA1/FZD2/ATP6AP1/RELN/FZD9/COMP/NOTCH2/TSC1/FZD3/WNT9B/HEY2/COL4A4/GNAS/FN1/ITGA6/AXIN1/COL4A3/CCNA1/MDM2/THBS4/CHUK/MAPK3	34
KEGG	hsa04141	Protein processing in endoplasmic reticulum	19/669	171/8144	0.1081	1	1	EIF2S1/HSPA1L/DNAJC10/SEC23A/UBXN4/NGLY1/DNAJC3/MOGS/DNAJB1/RAD23A/MAN1A2/SEC61B/HERPUD1/NFE2L2/HSPH1/SEL1L2/UBXN8/HSP90B1/HSPA6	19
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	9/669	69/8144	0.1103	1	1	CYP2A7/UGT2B11/CYP3A5/CYP2A6/SULT1A2/SULT1A3/SULT1A4/MGST2/UGT2B15	9
KEGG	hsa04211	Longevity regulating pathway	11/669	89/8144	0.1115	1	1	PRKAG1/SIRT1/RB1CC1/PRKAB2/KL/SESN3/ADCY8/TSC1/IGF1/SESN2/IRS4	11
KEGG	hsa04727	GABAergic synapse	11/669	89/8144	0.1115	1	1	GAD2/HAP1/GNG3/GABRA4/GLUL/ADCY8/GNG13/GLS/GNB4/GABARAP/GABRA1	11
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/669	89/8144	0.1115	1	1	IFNGR1/LAT/CSNK2A1/CD4/PTEN/ZAP70/CD274/FOS/CSNK2A2/CHUK/MAPK3	11
KEGG	hsa05110	Vibrio cholerae infection	7/669	50/8144	0.1125	1	1	ACTG1/ATP6V1D/TJP1/SEC61B/ATP6AP1/GNAS/KDELR2	7
KEGG	hsa03060	Protein export	4/669	23/8144	0.1149	1	1	SRP54/SEC61B/SEC11C/SRP19	4
KEGG	hsa04216	Ferroptosis	6/669	41/8144	0.116	1	1	MAP1LC3B2/GCLM/SLC39A8/ACSL4/VDAC3/LPCAT3	6
KEGG	hsa05205	Proteoglycans in cancer	22/669	205/8144	0.1172	1	1	ACTG1/WNT8B/GRB2/FZD1/ELK1/FZD2/FZD9/BRAF/FZD3/WNT9B/TWIST1/RAC1/ESR1/IGF1/MMP9/FN1/SMO/KDR/HOXD10/MDM2/CAV2/MAPK3	22
KEGG	hsa00730	Thiamine metabolism	3/669	15/8144	0.1198	1	1	AK5/NFS1/AK2	3
KEGG	hsa04916	Melanogenesis	12/669	101/8144	0.1238	1	1	DVL2/WNT8B/FZD1/KITLG/FZD2/KIT/FZD9/ADCY8/FZD3/WNT9B/GNAS/MAPK3	12
KEGG	hsa05032	Morphine addiction	11/669	91/8144	0.1251	1	1	GNG3/PDE4D/GABRA4/ADCY8/GNG13/PDE8B/GNAS/GNB4/PDE3B/GABRA1/PDE10A	11
KEGG	hsa04130	SNARE interactions in vesicular transport	5/669	33/8144	0.1298	1	1	STX3/STX2/BET1L/SNAP29/STX7	5
KEGG	hsa04213	Longevity regulating pathway - multiple species	8/669	62/8144	0.1334	1	1	HSPA1L/PRKAG1/SIRT1/PRKAB2/ADCY8/IGF1/HSPA6/IRS4	8
KEGG	hsa04934	Cushing syndrome	17/669	155/8144	0.1342	1	1	DVL2/WNT8B/CDK4/RAP1B/FZD1/FZD2/FZD9/ADCY8/BRAF/FZD3/WNT9B/PDE8B/GNAS/ARMC5/AXIN1/ORAI1/MAPK3	17
KEGG	hsa04115	p53 signaling pathway	9/669	73/8144	0.1424	1	1	MDM4/CDK1/CDK4/ATR/PTEN/SESN3/IGF1/SESN2/MDM2	9
KEGG	hsa01200	Carbon metabolism	13/669	115/8144	0.1483	1	1	GCSH/PSPH/GLUD1/SUCLG1/ACO2/OGDHL/PGLS/MDH1/HK2/TPI1/ACSS1/SUCLA2/DLD	13
KEGG	hsa03010	Ribosome	17/669	158/8144	0.1514	1	1	MRPL13/MRPS2/RPS14/MRPS7/MRPL17/RPS27L/RPL10A/RPL10/MRPL24/MRPL30/MRPS16/RPL35A/RPS4Y1/MRPL35/RPL37A/RPL10L/RPL3L	17
KEGG	hsa05214	Glioma	9/669	75/8144	0.1601	1	1	CDK4/GRB2/PTEN/TGFA/BRAF/SHC4/IGF1/MDM2/MAPK3	9
KEGG	hsa03022	Basal transcription factors	6/669	45/8144	0.1607	1	1	GTF2F2/TAF13/GTF2H5/TAF5L/GTF2H1/TAF11	6
KEGG	hsa00230	Purine metabolism	14/669	128/8144	0.1651	1	1	PDE9A/PDE6D/GDA/NUDT5/PDE4D/AK3/AK5/ADCY8/AMPD2/PDE8B/ADA/PDE3B/AK2/PDE10A	14
KEGG	hsa04742	Taste transduction	10/669	86/8144	0.1663	1	1	P2RY1/TAS2R19/TAS2R20/TAS2R31/GABRA4/TAS2R43/ADCY8/TAS2R13/GNG13/GABRA1	10
KEGG	hsa05210	Colorectal cancer	10/669	86/8144	0.1663	1	1	RAC3/GRB2/BCL2L11/TGFA/DCC/BRAF/RAC1/FOS/AXIN1/MAPK3	10
KEGG	hsa05418	Fluid shear stress and atherosclerosis	15/669	139/8144	0.1671	1	1	RAC3/ACTG1/BMPR2/NFE2L2/MGST2/RAC1/FOS/MMP9/KDR/CYBA/SUMO4/HSP90B1/CHUK/CAV2/NPPC	15
KEGG	hsa05215	Prostate cancer	11/669	97/8144	0.171	1	1	ETV5/GRB2/PTEN/TGFA/BRAF/IGF1/MMP9/HSP90B1/MDM2/CHUK/MAPK3	11
KEGG	hsa04140	Autophagy - animal	15/669	141/8144	0.1809	1	1	EIF2S1/MTMR3/MAP1LC3B2/PPP2CA/WIPI2/PTEN/RB1CC1/ATG2B/RRAGC/TSC1/SNAP29/GABARAP/UVRAG/IRS4/MAPK3	15
KEGG	hsa05221	Acute myeloid leukemia	8/669	67/8144	0.182	1	1	CCNA2/GRB2/KIT/BRAF/PIM2/CCNA1/CHUK/MAPK3	8
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	5/669	37/8144	0.1837	1	1	GAD2/RIMKLA/GLUD1/GLUL/GLS	5
KEGG	hsa03420	Nucleotide excision repair	6/669	47/8144	0.1854	1	1	XPA/CETN2/RAD23A/GTF2H5/POLE4/GTF2H1	6
KEGG	hsa04068	FoxO signaling pathway	14/669	131/8144	0.1867	1	1	PRKAG1/GRB2/PTEN/SIRT1/PRKAB2/BCL2L11/BRAF/GABARAP/IGF1/HOMER1/IRS4/MDM2/CHUK/MAPK3	14
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	14/669	131/8144	0.1867	1	1	IFNGR1/RAET1G/LAT/RAC3/KLRC3/GRB2/ZAP70/KIR2DL3/BRAF/SHC4/RAC1/ULBP3/RAET1L/MAPK3	14
KEGG	hsa01240	Biosynthesis of cofactors	16/669	153/8144	0.1888	1	1	UGT2B11/UMPS/MAT2B/MOCS1/CTPS2/COQ7/AK3/AK5/MTHFD2L/NFS1/GCLM/CMPK2/ALDH2/AK2/DLD/UGT2B15	16
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/669	79/8144	0.1984	1	1	GRB2/PTEN/BCL2L11/TGFA/BRAF/SHC4/IGF1/KDR/MAPK3	9
KEGG	hsa05168	Herpes simplex virus 1 infection	46/669	495/8144	0.2049	1	1	ZNF878/EIF2S1/IFNGR1/ZNF184/ZNF441/ZNF440/ZNF564/ZNF383/ZNF430/ZNF433/ZNF99/ZNF649/ZNF675/ZNF550/ZNF768/ZFP1/DDX58/ZNF514/ZNF554/ZNF823/ZNF230/ZNF324/ZNF253/ZNF182/ZNF799/ZNF141/ZNF107/ZNF567/ZNF133/ZNF682/ZNF26/ZNF557/ZNF490/ZNF853/ZNF257/TSC1/ZNF442/ZNF416/BST2/ZNF727/ZNF350/ZNF615/ZNF33A/ZNF605/ZNF429/CHUK	46
KEGG	hsa04390	Hippo signaling pathway	16/669	157/8144	0.2174	1	1	PPP2CA/DVL2/ACTG1/BMP7/WNT8B/FZD1/BMPR2/FZD2/FZD9/FZD3/WNT9B/BMP2/AXIN1/BMP8A/BMP8B/LATS2	16
KEGG	hsa04658	Th1 and Th2 cell differentiation	10/669	92/8144	0.2218	1	1	IFNGR1/LAT/CD4/MAF/ZAP70/NOTCH2/FOS/IL2/CHUK/MAPK3	10
KEGG	hsa00100	Steroid biosynthesis	3/669	20/8144	0.2234	1	1	NSDHL/SQLE/DHCR7	3
KEGG	hsa04724	Glutamatergic synapse	12/669	114/8144	0.2249	1	1	GRIN2C/GNG3/DLGAP1/GLUL/ADCY8/GNG13/GLS/GNAS/GNB4/HOMER1/MAPK3/SLC17A7	12
KEGG	hsa00260	Glycine, serine and threonine metabolism	5/669	40/8144	0.2287	1	1	GCSH/GCAT/PSPH/GNMT/DLD	5
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/669	30/8144	0.2295	1	1	UGT2B11/KL/ALDH2/UGT2B15	4
KEGG	hsa04110	Cell cycle	13/669	126/8144	0.234	1	1	CCNA2/DBF4/CDK1/CDK4/PTTG1/ATR/ANAPC5/CDC23/STAG2/BUB1/MAD2L2/CCNA1/MDM2	13
KEGG	hsa04657	IL-17 signaling pathway	10/669	94/8144	0.2418	1	1	ANAPC5/CXCL3/FOSL1/IL17RA/FOS/MMP9/IL17RB/HSP90B1/CHUK/MAPK3	10
KEGG	hsa04915	Estrogen signaling pathway	14/669	138/8144	0.2421	1	1	HSPA1L/GRB2/KRT14/TGFA/ADCY8/SHC4/GNAS/ESR1/FOS/MMP9/EBAG9/HSP90B1/HSPA6/MAPK3	14
KEGG	hsa03440	Homologous recombination	5/669	41/8144	0.2443	1	1	RBBP8/BARD1/MUS81/PALB2/RAD54L	5
KEGG	hsa05219	Bladder cancer	5/669	41/8144	0.2443	1	1	CDK4/BRAF/MMP9/MDM2/MAPK3	5
KEGG	hsa00640	Propanoate metabolism	4/669	32/8144	0.2663	1	1	SUCLG1/ACSS1/SUCLA2/DLD	4
KEGG	hsa04136	Autophagy - other	4/669	32/8144	0.2663	1	1	PPP2CA/WIPI2/ATG2B/GABARAP	4
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/669	53/8144	0.267	1	1	AP2B1/KL/GNAS/ESR1/KLK2/RAB11A	6
KEGG	hsa00220	Arginine biosynthesis	3/669	22/8144	0.2688	1	1	GLUD1/GLUL/GLS	3
KEGG	hsa03013	Nucleocytoplasmic transport	11/669	108/8144	0.2721	1	1	SENP2/RANBP2/POM121C/NUP37/NUP153/XPO4/THOC1/MAGOHB/SUMO4/TNPO3/NUP160	11
KEGG	hsa04015	Rap1 signaling pathway	20/669	210/8144	0.2758	1	1	LAT/RAC3/P2RY1/ACTG1/RAP1B/MAGI3/LPAR4/KITLG/KIT/ADCY8/BRAF/PFN2/GNAS/DRD2/RAC1/IGF1/TLN1/SKAP1/KDR/MAPK3	20
KEGG	hsa04152	AMPK signaling pathway	12/669	120/8144	0.2804	1	1	CCNA2/PRKAG1/RAB14/PPP2CA/SIRT1/PRKAB2/PFKFB4/TSC1/RAB10/IGF1/IRS4/CCNA1	12
KEGG	hsa05010	Alzheimer disease	35/669	384/8144	0.2813	1	1	EIF2S1/CSNK2A1/GRIN2C/DVL2/WIPI2/NDUFV3/CSNK1A1/SLC25A4/NDUFB1/WNT8B/FZD1/RB1CC1/NDUFA6/COX6A1/FZD2/NDUFB11/ATG2B/TUBB2B/FZD9/PSMD2/BRAF/SLC39A8/COX8A/FZD3/WNT9B/VDAC3/RTN4/CSNK2A2/FRAT2/NDUFA3/AXIN1/IRS4/CHUK/COX6B1/MAPK3	35
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	11/669	109/8144	0.2822	1	1	CSNK2A1/POP1/BMS1/RMRP/RIOK1/GAR1/RRP7A/GNL3L/RPP38/MDN1/CSNK2A2	11
KEGG	hsa05220	Chronic myeloid leukemia	8/669	76/8144	0.2847	1	1	MECOM/CDK4/GRB2/BRAF/SHC4/MDM2/CHUK/MAPK3	8
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/669	223/8144	0.2869	1	1	NDUFV3/SLC25A4/NDUFB1/GRB2/SLC26A1/PTEN/NDUFA6/COX6A1/NDUFB11/BRAF/NFE2L2/COX8A/MGST2/RAC1/VDAC3/FOS/NDUFA3/CYBA/CHUK/COX6B1/MAPK3	21
KEGG	hsa04932	Non-alcoholic fatty liver disease	15/669	155/8144	0.291	1	1	EIF2S1/PRKAG1/NDUFV3/NDUFB1/NDUFA6/COX6A1/PRKAB2/NDUFB11/MLX/BCL2L11/COX8A/RAC1/FOS/NDUFA3/COX6B1	15
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	3/669	23/8144	0.2919	1	1	GLUD1/MDH1/GLS	3
KEGG	hsa04512	ECM-receptor interaction	9/669	88/8144	0.2959	1	1	NPNT/LAMA1/RELN/COMP/COL4A4/FN1/ITGA6/COL4A3/THBS4	9
KEGG	hsa04721	Synaptic vesicle cycle	8/669	78/8144	0.3094	1	1	STX3/RAB3A/AP2B1/ATP6V1D/STX2/SLC6A7/CPLX2/SLC17A7	8
KEGG	hsa03018	RNA degradation	8/669	79/8144	0.3219	1	1	PABPC4/PABPC1/PABPC1L2B/EXOSC4/EXOSC8/EXOSC7/EDC3/CNOT4	8
KEGG	hsa00830	Retinol metabolism	7/669	68/8144	0.3242	1	1	CYP2A7/UGT2B11/CYP3A5/CYP2A6/PNPLA4/CYP26A1/UGT2B15	7
KEGG	hsa04670	Leukocyte transendothelial migration	11/669	114/8144	0.3339	1	1	ACTG1/RAP1B/MYL12A/CLDN10/CLDN11/CXCR4/MYL10/RAC1/MMP9/CYBA/OCLN	11
KEGG	hsa05211	Renal cell carcinoma	7/669	69/8144	0.3378	1	1	RAP1B/GRB2/EPAS1/TGFA/BRAF/RAC1/MAPK3	7
KEGG	hsa05226	Gastric cancer	14/669	149/8144	0.3395	1	1	DVL2/CSNK1A1/WNT8B/GRB2/FZD1/FZD2/FZD9/BRAF/SHC4/FZD3/WNT9B/FRAT2/AXIN1/MAPK3	14
KEGG	hsa05213	Endometrial cancer	6/669	58/8144	0.3407	1	1	GRB2/PTEN/ELK1/BRAF/AXIN1/MAPK3	6
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/669	70/8144	0.3516	1	1	IGSF5/ATP6V1D/CXCL3/TJP1/ATP6AP1/RAC1/CHUK	7
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/669	15/8144	0.3525	1	1	A4GALT/HEXA	2
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/669	15/8144	0.3525	1	1	HEXA/B4GALNT1	2
KEGG	hsa04714	Thermogenesis	21/669	232/8144	0.3529	1	1	PRKAG1/NDUFV3/ACTG1/NDUFB1/COX11/GRB2/NPPB/NDUFA6/ARID1A/COX6A1/PRKAB2/NDUFB11/ADCY8/TSC1/COX8A/GNAS/ACSL4/NDUFA3/BMP8A/BMP8B/COX6B1	21
KEGG	hsa04662	B cell receptor signaling pathway	8/669	82/8144	0.3599	1	1	RAC3/IFITM1/LILRB3/GRB2/RAC1/FOS/CHUK/MAPK3	8
KEGG	hsa04520	Adherens junction	7/669	71/8144	0.3653	1	1	CSNK2A1/RAC3/ACTG1/TJP1/RAC1/CSNK2A2/MAPK3	7
KEGG	hsa04350	TGF-beta signaling pathway	9/669	94/8144	0.3666	1	1	PPP2CA/FST/ZFYVE9/BMP7/BMPR2/BMP2/BMP8A/BMP8B/MAPK3	9
KEGG	hsa04926	Relaxin signaling pathway	12/669	129/8144	0.3701	1	1	GRB2/GNG3/ADCY8/SHC4/GNG13/COL4A4/GNAS/GNB4/FOS/MMP9/COL4A3/MAPK3	12
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	5/669	49/8144	0.3761	1	1	GALK1/HEXA/HK2/AMDHD2/CYB5RL	5
KEGG	hsa05340	Primary immunodeficiency	4/669	38/8144	0.3811	1	1	CD4/ZAP70/ADA/ORAI1	4
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/669	16/8144	0.383	1	1	GAD2/GGT5	2
KEGG	hsa00062	Fatty acid elongation	3/669	27/8144	0.3846	1	1	ELOVL5/ELOVL6/ELOVL4	3
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/669	27/8144	0.3846	1	1	ELOVL5/ELOVL6/ELOVL4	3
KEGG	hsa05020	Prion disease	24/669	273/8144	0.3943	1	1	EIF2S1/HSPA1L/CSNK2A1/GRIN2C/NDUFV3/SLC25A4/NDUFB1/NDUFA6/COX6A1/NDUFB11/TUBB2B/PSMD2/COX8A/C8G/RAC1/VDAC3/C1QA/CSNK2A2/NDUFA3/CYBA/HSPA6/COX6B1/CAV2/MAPK3	24
KEGG	hsa01232	Nucleotide metabolism	8/669	85/8144	0.3984	1	1	GDA/CTPS2/AK3/AK5/CMPK2/AMPD2/ADA/AK2	8
KEGG	hsa04144	Endocytosis	22/669	251/8144	0.4071	1	1	HSPA1L/PSD/ZFYVE9/ARFGAP2/AP2B1/SH3GL2/VPS26B/CAPZA1/LDLRAP1/CHMP1A/RAB10/CHMP2B/CXCR4/SNX32/STAM2/SNX12/VPS25/HSPA6/MDM2/CHMP4C/RAB11A/CAV2	22
KEGG	hsa04062	Chemokine signaling pathway	17/669	192/8144	0.41	1	1	RAC3/CXCL11/RAP1B/GRB2/CXCL3/GNG3/ADCY8/BRAF/SHC4/CCR10/GNG13/CXCR4/GNB4/RAC1/CXCR6/CHUK/MAPK3	17
KEGG	hsa00120	Primary bile acid biosynthesis	2/669	17/8144	0.4129	1	1	ACOT8/SLC27A5	2
KEGG	hsa04530	Tight junction	15/669	169/8144	0.4163	1	1	PRKAG1/PPP2CA/IGSF5/ACTG1/CDK4/BVES/MYL12A/TJP1/PRKAB2/CLDN10/CLDN11/ARHGAP17/RAC1/TJAP1/OCLN	15
KEGG	hsa05033	Nicotine addiction	4/669	40/8144	0.4193	1	1	GRIN2C/GABRA4/GABRA1/SLC17A7	4
KEGG	hsa00190	Oxidative phosphorylation	12/669	134/8144	0.4215	1	1	NDUFV3/NDUFB1/COX11/ATP6V1D/NDUFA6/COX6A1/NDUFB11/ATP6AP1/COX8A/NDUFA3/COX6B1/PPA1	12
KEGG	hsa05212	Pancreatic cancer	7/669	76/8144	0.4344	1	1	RAC3/CDK4/TGFA/BRAF/RAC1/CHUK/MAPK3	7
KEGG	hsa04540	Gap junction	8/669	88/8144	0.4369	1	1	CDK1/GRB2/TJP1/TUBB2B/ADCY8/GNAS/DRD2/MAPK3	8
KEGG	hsa00511	Other glycan degradation	2/669	18/8144	0.442	1	1	MANBA/HEXA	2
KEGG	hsa04723	Retrograde endocannabinoid signaling	13/669	148/8144	0.4429	1	1	NDUFV3/NDUFB1/GNG3/NDUFA6/NDUFB11/GABRA4/ADCY8/GNG13/GNB4/NDUFA3/GABRA1/MAPK3/SLC17A7	13
KEGG	hsa04014	Ras signaling pathway	20/669	232/8144	0.4448	1	1	RASA2/LAT/RAC3/RAP1B/GRB2/GNG3/ELK1/ZAP70/KITLG/KIT/TGFA/SHC4/GNG13/GNB4/RAC1/NTF3/IGF1/KDR/CHUK/MAPK3	20
KEGG	hsa05100	Bacterial invasion of epithelial cells	7/669	77/8144	0.4482	1	1	ACTG1/SHC4/MAD2L2/RAC1/FN1/CD2AP/CAV2	7
KEGG	hsa04910	Insulin signaling pathway	12/669	137/8144	0.4525	1	1	RHOQ/PRKAG1/GRB2/ELK1/PRKAB2/BRAF/HK2/SHC4/TSC1/PDE3B/IRS4/MAPK3	12
KEGG	hsa04151	PI3K-Akt signaling pathway	30/669	354/8144	0.4569	1	1	PPP2CA/CDK4/GRB2/PTEN/LPAR4/LAMA1/GNG3/KITLG/BCL2L11/RELN/KIT/TGFA/COMP/TSC1/GNG13/COL4A4/GNB4/RAC1/NTF3/IGF1/FN1/ITGA6/KDR/COL4A3/HSP90B1/IL2/MDM2/THBS4/CHUK/MAPK3	30
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	6/669	66/8144	0.4609	1	1	RARS2/QRSL1/GATC/IARS2/FARSA/MARS2	6
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	19/669	222/8144	0.461	1	1	CCNA2/SLC25A4/CD4/CDK4/PTTG1/ATR/PTEN/ANAPC5/CDC23/ELK1/FOSL1/ADCY8/VDAC3/FOS/TLN1/IL2/CCNA1/CHUK/MAPK3	19
KEGG	hsa04612	Antigen processing and presentation	7/669	78/8144	0.4618	1	1	HSPA1L/KLRC3/CD4/LGMN/KIR2DL3/PSME3/HSPA6	7
KEGG	hsa00531	Glycosaminoglycan degradation	2/669	19/8144	0.4704	1	1	HEXA/SGSH	2
KEGG	hsa00071	Fatty acid degradation	4/669	43/8144	0.4755	1	1	ACADSB/ALDH2/ACSL4/CYP2U1	4
KEGG	hsa04660	T cell receptor signaling pathway	9/669	104/8144	0.4864	1	1	LAT/CD4/CDK4/GRB2/ZAP70/FOS/IL2/CHUK/MAPK3	9
KEGG	hsa05222	Small cell lung cancer	8/669	92/8144	0.4876	1	1	CDK4/PTEN/LAMA1/COL4A4/FN1/ITGA6/COL4A3/CHUK	8
KEGG	hsa04340	Hedgehog signaling pathway	5/669	56/8144	0.492	1	1	EFCAB7/CSNK1A1/CUL3/SMO/GPR161	5
KEGG	hsa04923	Regulation of lipolysis in adipocytes	5/669	56/8144	0.492	1	1	ADRB2/ADCY8/GNAS/PDE3B/IRS4	5
KEGG	hsa04962	Vasopressin-regulated water reabsorption	4/669	44/8144	0.4937	1	1	DYNC1LI1/GNAS/DYNLL1/RAB11A	4
KEGG	hsa00670	One carbon pool by folate	2/669	20/8144	0.4978	1	1	MTHFD2L/MTHFS	2
KEGG	hsa04924	Renin secretion	6/669	69/8144	0.5049	1	1	ADRB2/GNAS/PDE3B/KCNJ2/EDN3/ORAI1	6
KEGG	hsa01212	Fatty acid metabolism	5/669	57/8144	0.508	1	1	ELOVL5/ELOVL6/ACADSB/ACSL4/ELOVL4	5
KEGG	hsa04114	Oocyte meiosis	11/669	131/8144	0.516	1	1	PPP2CA/CDK1/PTTG1/ANAPC5/CDC23/SPDYE1/ADCY8/BUB1/MAD2L2/IGF1/MAPK3	11
KEGG	hsa00051	Fructose and mannose metabolism	3/669	33/8144	0.5168	1	1	PFKFB4/HK2/TPI1	3
KEGG	hsa03410	Base excision repair	3/669	33/8144	0.5168	1	1	PARP1/APEX2/POLE4	3
KEGG	hsa04917	Prolactin signaling pathway	6/669	70/8144	0.5193	1	1	SOCS7/GRB2/SHC4/ESR1/FOS/MAPK3	6
KEGG	hsa04218	Cellular senescence	13/669	156/8144	0.5211	1	1	CCNA2/SLC25A4/CDK1/CDK4/ATR/PTEN/SIRT1/TSC1/VDAC3/HUS1/CCNA1/MDM2/MAPK3	13
KEGG	hsa03050	Proteasome	4/669	46/8144	0.5295	1	1	PSMB10/PSMD2/PSME3/PSME4	4
KEGG	hsa05160	Hepatitis C	13/669	157/8144	0.5307	1	1	EIF2S1/PPP2CA/CDK4/GRB2/DDX58/CLDN10/BRAF/PSME3/CLDN11/EIF3E/CHUK/OCLN/MAPK3	13
KEGG	hsa04659	Th17 cell differentiation	9/669	108/8144	0.5331	1	1	IFNGR1/LAT/CD4/EBI3/ZAP70/FOS/IL2/CHUK/MAPK3	9
KEGG	hsa00040	Pentose and glucuronate interconversions	3/669	34/8144	0.5374	1	1	UGT2B11/KL/UGT2B15	3
KEGG	hsa03020	RNA polymerase	3/669	34/8144	0.5374	1	1	POLR3G/POLR2H/CD3EAP	3
KEGG	hsa04330	Notch signaling pathway	5/669	59/8144	0.5393	1	1	DVL2/HES5/NOTCH2/HEY2/CIR1	5
KEGG	hsa00620	Pyruvate metabolism	4/669	47/8144	0.5468	1	1	MDH1/ALDH2/ACSS1/DLD	4
KEGG	hsa00982	Drug metabolism - cytochrome P450	6/669	72/8144	0.5475	1	1	CYP2A7/UGT2B11/CYP3A5/CYP2A6/MGST2/UGT2B15	6
KEGG	hsa04137	Mitophagy - animal	6/669	72/8144	0.5475	1	1	CSNK2A1/MAP1LC3B2/NBR1/USP30/GABARAP/CSNK2A2	6
KEGG	hsa05218	Melanoma	6/669	72/8144	0.5475	1	1	CDK4/PTEN/BRAF/IGF1/MDM2/MAPK3	6
KEGG	hsa03015	mRNA surveillance pathway	8/669	97/8144	0.5492	1	1	CSTF2T/CPSF2/CPSF7/PPP2CA/PABPC4/PABPC1/PABPC1L2B/MAGOHB	8
KEGG	hsa04713	Circadian entrainment	8/669	97/8144	0.5492	1	1	GRIN2C/GNG3/ADCY8/GNG13/GNAS/GNB4/FOS/MAPK3	8
KEGG	hsa04730	Long-term depression	5/669	60/8144	0.5546	1	1	PPP2CA/BRAF/GNAS/IGF1/MAPK3	5
KEGG	hsa00562	Inositol phosphate metabolism	6/669	73/8144	0.5614	1	1	MTMR3/IPMK/PTEN/PI4K2B/TPI1/INPP5B	6
KEGG	hsa04210	Apoptosis	11/669	136/8144	0.5675	1	1	EIF2S1/LMNB1/ACTG1/CTSH/PARP1/BCL2L11/DFFA/FOS/PTPN13/CHUK/MAPK3	11
KEGG	hsa05206	MicroRNAs in cancer	25/669	310/8144	0.5703	1	1	MIR520A/MDM4/MIR520G/SOX4/GRB2/PTEN/SIRT1/MIR124-3/BMPR2/BCL2L11/MARCKS/MIR1-2/MIR30C1/NOTCH2/SHC4/MIR210/FZD3/GLS/MIR194-1/MIR215/MIR129-2/MMP9/HOXD10/MDM2/MAPK3	25
KEGG	hsa00350	Tyrosine metabolism	3/669	36/8144	0.577	1	1	PNMT/GSTZ1/MIF	3
KEGG	hsa05135	Yersinia infection	11/669	137/8144	0.5776	1	1	LAT/RAC3/ACTG1/CD4/ZAP70/RAC1/FOS/FN1/IL2/CHUK/MAPK3	11
KEGG	hsa04979	Cholesterol metabolism	4/669	50/8144	0.5969	1	1	LDLRAP1/ANGPTL4/VDAC3/NPC1	4
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/669	24/8144	0.598	1	1	HS3ST1/HS3ST3A1	2
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	38/669	476/8144	0.6009	1	1	UBE2L6/EIF2S1/CSNK2A1/GRIN2C/MAP1LC3B2/DVL2/WIPI2/NDUFV3/CSNK1A1/SLC25A4/NDUFB1/WNT8B/FZD1/HAP1/RB1CC1/NDUFA6/COX6A1/FZD2/NDUFB11/ATG2B/TUBB2B/FZD9/PSMD2/BRAF/UCHL1/CHMP2B/COX8A/FZD3/WNT9B/RAC1/VDAC3/CSNK2A2/FRAT2/NDUFA3/AXIN1/DNAH14/COX6B1/MAPK3	38
KEGG	hsa04145	Phagosome	12/669	152/8144	0.6012	1	1	ACTG1/PLA2R1/ATP6V1D/DYNC1LI1/SEC61B/ATP6AP1/TUBB2B/COMP/RAC1/STX7/CYBA/THBS4	12
KEGG	hsa05142	Chagas disease	8/669	102/8144	0.6076	1	1	IFNGR1/PPP2CA/GNAS/FOS/C1QA/IL2/CHUK/MAPK3	8
KEGG	hsa05146	Amoebiasis	8/669	102/8144	0.6076	1	1	CXCL3/LAMA1/SERPINB4/C8G/COL4A4/GNAS/FN1/COL4A3	8
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/669	11/8144	0.6107	1	1	COQ7	1
KEGG	hsa04380	Osteoclast differentiation	10/669	128/8144	0.6137	1	1	IFNGR1/JUNB/LILRB3/GRB2/FOSL1/RAC1/FOS/CYBA/CHUK/MAPK3	10
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/669	77/8144	0.6146	1	1	ACTG1/CDH2/LAMA1/DSG2/ITGA6/CACNG8	6
KEGG	hsa05410	Hypertrophic cardiomyopathy	7/669	90/8144	0.6165	1	1	PRKAG1/ACTG1/LAMA1/PRKAB2/IGF1/ITGA6/CACNG8	7
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/669	78/8144	0.6273	1	1	CYP2A7/UGT2B11/CYP3A5/CYP2A6/MGST2/UGT2B15	6
KEGG	hsa04064	NF-kappa B signaling pathway	8/669	104/8144	0.6298	1	1	LAT/CSNK2A1/CXCL3/PARP1/DDX58/ZAP70/CSNK2A2/CHUK	8
KEGG	hsa04010	MAPK signaling pathway	23/669	294/8144	0.6302	1	1	RASA2/HSPA1L/RAC3/MECOM/RAP1B/GRB2/MAP3K4/ELK1/KITLG/KIT/TGFA/BRAF/DUSP9/RAC1/FOS/NTF3/IGF1/MAP4K4/KDR/CACNG8/HSPA6/CHUK/MAPK3	23
KEGG	hsa04950	Maturity onset diabetes of the young	2/669	26/8144	0.6422	1	1	NEUROG3/BHLHA15	2
KEGG	hsa04024	cAMP signaling pathway	17/669	221/8144	0.6491	1	1	GRIN2C/RAC3/RAP1B/PDE4D/ADRB2/GLP1R/ADCY8/BRAF/GNAS/DRD2/RAC1/PDE3B/FOS/EDN3/ORAI1/PDE10A/MAPK3	17
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	8/669	106/8144	0.6513	1	1	PDE4D/KL/ADCY8/BRAF/GNAS/FOS/SLC34A2/MAPK3	8
KEGG	hsa04935	Growth hormone synthesis, secretion and action	9/669	119/8144	0.6519	1	1	JUNB/GRB2/ADCY8/SHC4/GNAS/FOS/IGF1/IRS4/MAPK3	9
KEGG	hsa00983	Drug metabolism - other enzymes	6/669	80/8144	0.6521	1	1	CYP2A7/UGT2B11/UMPS/CYP2A6/MGST2/UGT2B15	6
KEGG	hsa00010	Glycolysis / Gluconeogenesis	5/669	67/8144	0.6541	1	1	HK2/TPI1/ALDH2/ACSS1/DLD	5
KEGG	hsa04720	Long-term potentiation	5/669	67/8144	0.6541	1	1	GRIN2C/RAP1B/ADCY8/BRAF/MAPK3	5
KEGG	hsa04922	Glucagon signaling pathway	8/669	107/8144	0.6618	1	1	PRKAG1/SIRT1/SIK1/PRKAB2/SIK2/PPP4C/GNAS/PDE3B	8
KEGG	hsa04664	Fc epsilon RI signaling pathway	5/669	68/8144	0.6671	1	1	LAT/RAC3/GRB2/RAC1/MAPK3	5
KEGG	hsa04919	Thyroid hormone signaling pathway	9/669	121/8144	0.6715	1	1	SLC16A10/THRB/ACTG1/MED13/NOTCH2/MED4/ESR1/MDM2/MAPK3	9
KEGG	hsa04146	Peroxisome	6/669	82/8144	0.6758	1	1	ACOT8/ACSL4/PXMP2/PEX3/NUDT7/PEX11A	6
KEGG	hsa04920	Adipocytokine signaling pathway	5/669	69/8144	0.6798	1	1	PRKAG1/PRKAB2/ACSL4/IRS4/CHUK	5
KEGG	hsa00650	Butanoate metabolism	2/669	28/8144	0.6825	1	1	GAD2/BDH2	2
KEGG	hsa05414	Dilated cardiomyopathy	7/669	96/8144	0.6841	1	1	ACTG1/LAMA1/ADCY8/GNAS/IGF1/ITGA6/CACNG8	7
KEGG	hsa05161	Hepatitis B	12/669	162/8144	0.6891	1	1	CCNA2/GRB2/DDX58/ELK1/ATP6AP1/BRAF/VDAC3/FOS/MMP9/CCNA1/CHUK/MAPK3	12
KEGG	hsa05230	Central carbon metabolism in cancer	5/669	70/8144	0.6921	1	1	PTEN/KIT/HK2/GLS/MAPK3	5
KEGG	hsa04070	Phosphatidylinositol signaling system	7/669	97/8144	0.6946	1	1	MTMR3/IPMK/PTEN/DGKK/PI4K2B/INPP5B/CDS1	7
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/669	14/8144	0.6991	1	1	CHST2	1
KEGG	hsa04611	Platelet activation	9/669	124/8144	0.6997	1	1	P2RY1/ACTG1/RAP1B/MYL12A/ADCY8/GNAS/TLN1/ORAI1/MAPK3	9
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/669	29/8144	0.7012	1	1	FAT4/LATS2	2
KEGG	hsa05231	Choline metabolism in cancer	7/669	98/8144	0.7048	1	1	RAC3/GRB2/DGKK/TSC1/RAC1/FOS/MAPK3	7
KEGG	hsa05415	Diabetic cardiomyopathy	15/669	203/8144	0.7051	1	1	NDUFV3/SLC25A4/NDUFB1/PTEN/PARP1/NDUFA6/COX6A1/NDUFB11/COX8A/RAC1/VDAC3/MMP9/NDUFA3/CYBA/COX6B1	15
KEGG	hsa04012	ErbB signaling pathway	6/669	85/8144	0.7093	1	1	GRB2/ELK1/TGFA/BRAF/SHC4/MAPK3	6
KEGG	hsa04610	Complement and coagulation cascades	6/669	85/8144	0.7093	1	1	F13B/F3/C8G/F10/C1QA/PROC	6
KEGG	hsa05162	Measles	10/669	139/8144	0.7156	1	1	EIF2S1/HSPA1L/CSNK2A1/CDK4/DDX58/FOS/CSNK2A2/HSPA6/IL2/CHUK	10
KEGG	hsa05223	Non-small cell lung cancer	5/669	72/8144	0.7158	1	1	CDK4/GRB2/TGFA/BRAF/MAPK3	5
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/669	100/8144	0.7247	1	1	CDK4/F3/COL4A4/RAC1/FN1/COL4A3/MAPK3	7
KEGG	hsa04370	VEGF signaling pathway	4/669	59/8144	0.7255	1	1	RAC3/RAC1/KDR/MAPK3	4
KEGG	hsa05171	Coronavirus disease - COVID-19	17/669	232/8144	0.7259	1	1	F13B/RPS14/RPS27L/DDX58/RPL10A/RPL10/RPL35A/C8G/RPS4Y1/FOS/C1QA/RPL37A/RPL10L/IL2/RPL3L/CHUK/MAPK3	17
KEGG	hsa01524	Platinum drug resistance	5/669	73/8144	0.7272	1	1	XPA/SLC31A1/MGST2/MDM2/MAPK3	5
KEGG	hsa00052	Galactose metabolism	2/669	31/8144	0.7358	1	1	GALK1/HK2	2
KEGG	hsa00410	beta-Alanine metabolism	2/669	31/8144	0.7358	1	1	GAD2/ALDH2	2
KEGG	hsa04978	Mineral absorption	4/669	60/8144	0.7378	1	1	SLC31A1/MT1H/SLC34A2/ATOX1	4
KEGG	hsa05416	Viral myocarditis	4/669	60/8144	0.7378	1	1	RAC3/ACTG1/LAMA1/RAC1	4
KEGG	hsa04930	Type II diabetes mellitus	3/669	46/8144	0.7408	1	1	HK2/IRS4/MAPK3	3
KEGG	hsa04360	Axon guidance	13/669	182/8144	0.7417	1	1	RND1/RAC3/BMP7/MYL12A/BMPR2/LRIG2/DCC/FZD3/CXCR4/EPHA3/RAC1/SMO/MAPK3	13
KEGG	hsa05014	Amyotrophic lateral sclerosis	27/669	364/8144	0.7422	1	1	EIF2S1/GRIN2C/MAP1LC3B2/WIPI2/NDUFV3/ACTG1/RANBP2/NDUFB1/POM121C/HAP1/RB1CC1/NDUFA6/COX6A1/NDUFB11/NUP37/ATG2B/TUBB2B/NUP153/PSMD2/PFN2/CHMP2B/COX8A/RAC1/NDUFA3/DNAH14/COX6B1/NUP160	27
KEGG	hsa04972	Pancreatic secretion	7/669	102/8144	0.7436	1	1	CPA2/PNLIPRP2/RAP1B/ADCY8/GNAS/RAC1/RAB11A	7
KEGG	hsa00360	Phenylalanine metabolism	1/669	16/8144	0.7466	1	1	MIF	1
KEGG	hsa01230	Biosynthesis of amino acids	5/669	75/8144	0.7489	1	1	PSPH/MAT2B/ACO2/GLUL/TPI1	5
KEGG	hsa00140	Steroid hormone biosynthesis	4/669	61/8144	0.7495	1	1	UGT2B11/CYP3A5/SRD5A3/UGT2B15	4
KEGG	hsa00561	Glycerolipid metabolism	4/669	61/8144	0.7495	1	1	PNLIPRP2/DGKK/ALDH2/MOGAT1	4
KEGG	hsa00590	Arachidonic acid metabolism	4/669	61/8144	0.7495	1	1	GGT5/LTA4H/PTGES3/CYP2U1	4
KEGG	hsa04976	Bile secretion	6/669	89/8144	0.7502	1	1	UGT2B11/ABCB4/ADCY8/GNAS/UGT2B15/SLC27A5	6
KEGG	hsa04974	Protein digestion and absorption	7/669	103/8144	0.7527	1	1	CPA2/SLC16A10/COL12A1/COL4A4/MEP1A/DPP4/COL4A3	7
KEGG	hsa05164	Influenza A	12/669	171/8144	0.7575	1	1	EIF2S1/IFNGR1/DNAJC3/ACTG1/DNAJB1/SLC25A4/CDK4/DDX58/TPSAB1/CHUK/RAB11A/MAPK3	12
KEGG	hsa05170	Human immunodeficiency virus 1 infection	15/669	212/8144	0.7653	1	1	RAC3/CD4/CDK1/AP1M2/ATR/GNG3/APOBEC3D/GNG13/CXCR4/GNB4/BST2/RAC1/FOS/CHUK/MAPK3	15
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	15/669	212/8144	0.7653	1	1	UGT2B11/KLF5/GRB2/PTGES3/ADRB2/ADCY8/NOTCH2/KLF4/GNAS/MGST2/ESR1/FOS/HSP90B1/UGT2B15/MAPK3	15
KEGG	hsa00280	Valine, leucine and isoleucine degradation	3/669	48/8144	0.7667	1	1	ACADSB/ALDH2/DLD	3
KEGG	hsa04728	Dopaminergic synapse	9/669	132/8144	0.7672	1	1	PPP2CA/GNG3/CALY/GNG13/GNAS/GNB4/CLOCK/DRD2/FOS	9
KEGG	hsa00450	Selenocompound metabolism	1/669	17/8144	0.7675	1	1	MARS2	1
KEGG	hsa05140	Leishmaniasis	5/669	77/8144	0.7693	1	1	IFNGR1/ELK1/FOS/CYBA/MAPK3	5
KEGG	hsa00310	Lysine degradation	4/669	63/8144	0.7719	1	1	MECOM/SUV39H1/ALDH2/DLD	4
KEGG	hsa04623	Cytosolic DNA-sensing pathway	4/669	63/8144	0.7719	1	1	DDX58/POLR3G/POLR2H/CHUK	4
KEGG	hsa05012	Parkinson disease	19/669	266/8144	0.7729	1	1	UBE2L6/EIF2S1/NDUFV3/SLC25A4/NDUFB1/NDUFA6/COX6A1/NDUFB11/TUBB2B/PSMD2/SLC39A8/UCHL1/NFE2L2/COX8A/GNAS/DRD2/VDAC3/NDUFA3/COX6B1	19
KEGG	hsa05034	Alcoholism	13/669	187/8144	0.7753	1	1	GRIN2C/SLC29A1/GRB2/PKIA/GNG3/BRAF/SHC4/GNG13/SLC29A3/GNAS/GNB4/DRD2/MAPK3	13
KEGG	hsa00565	Ether lipid metabolism	3/669	49/8144	0.7789	1	1	UGT8/PAFAH1B2/PAFAH1B1	3
KEGG	hsa04672	Intestinal immune network for IgA production	3/669	49/8144	0.7789	1	1	CCR10/CXCR4/IL2	3
KEGG	hsa05030	Cocaine addiction	3/669	49/8144	0.7789	1	1	GRIN2C/GNAS/DRD2	3
KEGG	hsa05417	Lipid and atherosclerosis	15/669	215/8144	0.7834	1	1	CYP2A7/EIF2S1/HSPA1L/CYP2A6/RAP1B/CXCL3/NFE2L2/RAC1/FOS/MMP9/CYBA/HSP90B1/HSPA6/CHUK/MAPK3	15
KEGG	hsa04072	Phospholipase D signaling pathway	10/669	148/8144	0.7849	1	1	GRB2/DGKK/LPAR4/KITLG/KIT/ADCY8/SHC4/TSC1/GNAS/MAPK3	10
KEGG	hsa00061	Fatty acid biosynthesis	1/669	18/8144	0.7866	1	1	ACSL4	1
KEGG	hsa04912	GnRH signaling pathway	6/669	93/8144	0.7868	1	1	GRB2/MAP3K4/ELK1/ADCY8/GNAS/MAPK3	6
KEGG	hsa04060	Cytokine-cytokine receptor interaction	21/669	295/8144	0.7872	1	1	IFNGR1/TNFRSF12A/CXCL11/TNFSF15/BMP7/CD4/EBI3/CXCL3/BMPR2/IL11/TNFRSF25/IL17RA/CCR10/CXCR4/TNFRSF10C/BMP2/IL17RB/BMP8A/BMP8B/CXCR6/IL2	21
KEGG	hsa05144	Malaria	3/669	50/8144	0.7905	1	1	GYPB/COMP/THBS4	3
KEGG	hsa04927	Cortisol synthesis and secretion	4/669	65/8144	0.7927	1	1	ADCY8/PDE8B/GNAS/ORAI1	4
KEGG	hsa00270	Cysteine and methionine metabolism	3/669	51/8144	0.8016	1	1	MAT2B/MDH1/GCLM	3
KEGG	hsa04913	Ovarian steroidogenesis	3/669	51/8144	0.8016	1	1	ADCY8/GNAS/IGF1	3
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/669	19/8144	0.8042	1	1	ACO2	1
KEGG	hsa00512	Mucin type O-glycan biosynthesis	2/669	36/8144	0.8077	1	1	GALNT7/C1GALT1C1	2
KEGG	hsa03030	DNA replication	2/669	36/8144	0.8077	1	1	RNASEH2C/POLE4	2
KEGG	hsa04371	Apelin signaling pathway	9/669	139/8144	0.8168	1	1	PRKAG1/MAP1LC3B2/GNG3/PRKAB2/ADCY8/GNG13/GNB4/PDE3B/MAPK3	9
KEGG	hsa04022	cGMP-PKG signaling pathway	11/669	167/8144	0.819	1	1	SLC25A4/NPPB/ADRB2/ADCY8/ADRA2A/ADORA3/PDE3B/VDAC3/IRS4/NPPC/MAPK3	11
KEGG	hsa01250	Biosynthesis of nucleotide sugars	2/669	37/8144	0.8198	1	1	GALK1/HK2	2
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	2/669	37/8144	0.8198	1	1	IGF1/MAPK3	2
KEGG	hsa05216	Thyroid cancer	2/669	37/8144	0.8198	1	1	BRAF/MAPK3	2
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/669	20/8144	0.8203	1	1	CHSY3	1
KEGG	hsa00600	Sphingolipid metabolism	3/669	53/8144	0.8223	1	1	UGT8/HEXA/B4GALNT1	3
KEGG	hsa04921	Oxytocin signaling pathway	10/669	154/8144	0.8238	1	1	PRKAG1/ACTG1/ELK1/PRKAB2/ADCY8/GNAS/FOS/KCNJ2/CACNG8/MAPK3	10
KEGG	hsa05145	Toxoplasmosis	7/669	112/8144	0.8243	1	1	IFNGR1/HSPA1L/LAMA1/ITGA6/HSPA6/CHUK/MAPK3	7
KEGG	hsa00564	Glycerophospholipid metabolism	6/669	98/8144	0.8266	1	1	PHOSPHO1/DGKK/TAZ/ETNK1/LPCAT3/CDS1	6
KEGG	hsa05031	Amphetamine addiction	4/669	69/8144	0.8296	1	1	GRIN2C/SIRT1/GNAS/FOS	4
KEGG	hsa04725	Cholinergic synapse	7/669	113/8144	0.8311	1	1	GNG3/ADCY8/GNG13/GNB4/FOS/KCNJ2/MAPK3	7
KEGG	hsa05130	Pathogenic Escherichia coli infection	13/669	197/8144	0.8331	1	1	MYO5C/ACTG1/LPAR4/TJP1/TUBB2B/CLDN10/MYO1D/CLDN11/RAC1/FOS/CHUK/OCLN/MAPK3	13
KEGG	hsa00770	Pantothenate and CoA biosynthesis	1/669	21/8144	0.8351	1	1	ALDH2	1
KEGG	hsa05163	Human cytomegalovirus infection	15/669	225/8144	0.8366	1	1	RAC3/CDK4/GRB2/GNG3/ELK1/ADCY8/TSC1/GNG13/CXCR4/GNAS/GNB4/RAC1/MDM2/CHUK/MAPK3	15
KEGG	hsa04622	RIG-I-like receptor signaling pathway	4/669	70/8144	0.838	1	1	DDX58/OTUD5/AZI2/CHUK	4
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/669	100/8144	0.8408	1	1	CXCL11/CXCL3/CCR10/CXCR4/TNFRSF10C/IL2	6
KEGG	hsa05017	Spinocerebellar ataxia	9/669	143/8144	0.8413	1	1	AFG3L2/GRIN2C/WIPI2/SLC25A4/RB1CC1/RELN/ATG2B/PSMD2/VDAC3	9
KEGG	hsa00340	Histidine metabolism	1/669	22/8144	0.8487	1	1	ALDH2	1
KEGG	hsa00900	Terpenoid backbone biosynthesis	1/669	22/8144	0.8487	1	1	FNTA	1
KEGG	hsa04217	Necroptosis	10/669	159/8144	0.8519	1	1	IFNGR1/GLUD1/SLC25A4/PARP1/CHMP1A/FAF1/GLUL/CHMP2B/VDAC3/CHMP4C	10
KEGG	hsa05134	Legionellosis	3/669	57/8144	0.8583	1	1	HSPA1L/CXCL3/HSPA6	3
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/669	23/8144	0.8611	1	1	B3GAT2	1
KEGG	hsa03430	Mismatch repair	1/669	23/8144	0.8611	1	1	PMS2	1
KEGG	hsa04614	Renin-angiotensin system	1/669	23/8144	0.8611	1	1	KLK2	1
KEGG	hsa00240	Pyrimidine metabolism	3/669	58/8144	0.8662	1	1	UMPS/CTPS2/CMPK2	3
KEGG	hsa00480	Glutathione metabolism	3/669	58/8144	0.8662	1	1	GGT5/GCLM/MGST2	3
KEGG	hsa04810	Regulation of actin cytoskeleton	14/669	218/8144	0.8669	1	1	FGD3/RAC3/ACTG1/MYL12A/LPAR4/BRAF/PFN2/CXCR4/MYL10/RAC1/FN1/ITGA6/TMSB4X/MAPK3	14
KEGG	hsa04722	Neurotrophin signaling pathway	7/669	119/8144	0.8679	1	1	RAP1B/GRB2/BRAF/SHC4/RAC1/NTF3/MAPK3	7
KEGG	hsa00380	Tryptophan metabolism	2/669	42/8144	0.8707	1	1	ALDH2/DLD	2
KEGG	hsa05332	Graft-versus-host disease	2/669	42/8144	0.8707	1	1	KIR2DL3/IL2	2
KEGG	hsa04977	Vitamin digestion and absorption	1/669	24/8144	0.8726	1	1	SLC19A2	1
KEGG	hsa04514	Cell adhesion molecules	9/669	149/8144	0.8732	1	1	CD4/CDH2/NLGN4Y/CD274/CLDN10/CLDN11/NLGN1/ITGA6/OCLN	9
KEGG	hsa03320	PPAR signaling pathway	4/669	75/8144	0.8747	1	1	PLIN2/ANGPTL4/ACSL4/SLC27A5	4
KEGG	hsa00860	Porphyrin metabolism	2/669	43/8144	0.8791	1	1	UGT2B11/UGT2B15	2
KEGG	hsa04940	Type I diabetes mellitus	2/669	43/8144	0.8791	1	1	GAD2/IL2	2
KEGG	hsa04971	Gastric acid secretion	4/669	76/8144	0.8811	1	1	ACTG1/ADCY8/GNAS/KCNJ2	4
KEGG	hsa05323	Rheumatoid arthritis	5/669	93/8144	0.8896	1	1	ATP6V1D/CXCL3/IL11/ATP6AP1/FOS	5
KEGG	hsa00790	Folate biosynthesis	1/669	26/8144	0.8927	1	1	MOCS1	1
KEGG	hsa04621	NOD-like receptor signaling pathway	11/669	184/8144	0.8997	1	1	TXNIP/MAP1LC3B2/CXCL3/CARD16/DHX33/GABARAP/VDAC3/CYBA/CARD8/CHUK/MAPK3	11
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/669	27/8144	0.9016	1	1	A4GALT	1
KEGG	hsa04966	Collecting duct acid secretion	1/669	27/8144	0.9016	1	1	ATP6V1D	1
KEGG	hsa04936	Alcoholic liver disease	8/669	142/8144	0.9065	1	1	PRKAG1/SIRT1/CXCL3/PRKAB2/IL17RA/ALDH2/C1QA/CHUK	8
KEGG	hsa04668	TNF signaling pathway	6/669	112/8144	0.9072	1	1	JUNB/CXCL3/FOS/MMP9/CHUK/MAPK3	6
KEGG	hsa00514	Other types of O-glycan biosynthesis	2/669	47/8144	0.908	1	1	GALNT7/C1GALT1C1	2
KEGG	hsa05321	Inflammatory bowel disease	3/669	65/8144	0.9116	1	1	IFNGR1/MAF/IL2	3
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	5/669	98/8144	0.9139	1	1	TRPM8/TRPV1/ADCY8/GNAS/IGF1	5
KEGG	hsa04640	Hematopoietic cell lineage	5/669	99/8144	0.9182	1	1	CD4/IL11/KITLG/KIT/ITGA6	5
KEGG	hsa05131	Shigellosis	15/669	247/8144	0.9185	1	1	MAP1LC3B2/WIPI2/ACTG1/MYL12A/FNBP1L/CAPNS1/HK2/PFN2/RRAGC/MYL10/RAC1/TLN1/MDM2/CHUK/MAPK3	15
KEGG	hsa04726	Serotonergic synapse	6/669	115/8144	0.9195	1	1	GNG3/BRAF/GNG13/GNAS/GNB4/MAPK3	6
KEGG	hsa05132	Salmonella infection	15/669	249/8144	0.9238	1	1	ARL8B/ACTG1/MYL12A/DYNC1LI1/RHOB/TUBB2B/PFN2/MYL10/RAC1/FOS/VPS16/HSP90B1/DYNLL1/CHUK/MAPK3	15
KEGG	hsa00030	Pentose phosphate pathway	1/669	30/8144	0.9239	1	1	PGLS	1
KEGG	hsa01523	Antifolate resistance	1/669	30/8144	0.9239	1	1	CHUK	1
KEGG	hsa05016	Huntington disease	19/669	306/8144	0.9252	1	1	WIPI2/NDUFV3/SLC25A4/NDUFB1/AP2B1/HAP1/RB1CC1/NDUFA6/COX6A1/NDUFB11/ATG2B/TUBB2B/PSMD2/COX8A/VDAC3/POLR2H/NDUFA3/DNAH14/COX6B1	19
KEGG	hsa05202	Transcriptional misregulation in cancer	11/669	193/8144	0.9286	1	1	KLF3/CCNA2/ETV5/BMP2K/MAF/EWSR1/IGF1/MMP9/LDB1/CCNA1/MDM2	11
KEGG	hsa00330	Arginine and proline metabolism	2/669	51/8144	0.9303	1	1	ALDH2/CKB	2
KEGG	hsa04911	Insulin secretion	4/669	86/8144	0.931	1	1	RAB3A/GLP1R/ADCY8/GNAS	4
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/669	194/8144	0.9314	1	1	IFNGR1/MAP1LC3B2/CDK4/CXCL3/GNG3/GNG13/GNB4/RAC1/FOS/CHUK/MAPK3	11
KEGG	hsa04270	Vascular smooth muscle contraction	7/669	134/8144	0.9318	1	1	NPPB/ADCY8/BRAF/GNAS/EDN3/NPPC/MAPK3	7
KEGG	hsa04071	Sphingolipid signaling pathway	6/669	119/8144	0.9337	1	1	PPP2CA/RAC3/PTEN/RAC1/ADORA3/MAPK3	6
KEGG	hsa04260	Cardiac muscle contraction	4/669	87/8144	0.9348	1	1	COX6A1/COX8A/CACNG8/COX6B1	4
KEGG	hsa04215	Apoptosis - multiple species	1/669	32/8144	0.936	1	1	BCL2L11	1
KEGG	hsa04620	Toll-like receptor signaling pathway	5/669	104/8144	0.9368	1	1	CXCL11/RAC1/FOS/CHUK/MAPK3	5
KEGG	hsa04625	C-type lectin receptor signaling pathway	5/669	104/8144	0.9368	1	1	CLEC1B/IL2/MDM2/CHUK/MAPK3	5
KEGG	hsa04931	Insulin resistance	5/669	108/8144	0.9489	1	1	PRKAG1/PTEN/PRKAB2/MLX/SLC27A5	5
KEGG	hsa04918	Thyroid hormone synthesis	3/669	75/8144	0.9524	1	1	ADCY8/GNAS/HSP90B1	3
KEGG	hsa04120	Ubiquitin mediated proteolysis	7/669	142/8144	0.9533	1	1	UBE2L6/CUL7/ANAPC5/CDC23/HERC1/CUL3/MDM2	7
KEGG	hsa05203	Viral carcinogenesis	11/669	204/8144	0.9541	1	1	RASA2/CCNA2/CDK1/CDK4/GRB2/RAC1/VDAC3/GTF2H1/CCNA1/MDM2/MAPK3	11
KEGG	hsa00500	Starch and sucrose metabolism	1/669	36/8144	0.9546	1	1	HK2	1
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	1/669	36/8144	0.9546	1	1	SIRT1	1
KEGG	hsa05133	Pertussis	3/669	76/8144	0.9553	1	1	FOS/C1QA/MAPK3	3
KEGG	hsa05330	Allograft rejection	1/669	38/8144	0.9618	1	1	IL2	1
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	4/669	97/8144	0.9634	1	1	LAT/MARCKS/RAC1/MAPK3	4
KEGG	hsa05169	Epstein-Barr virus infection	10/669	202/8144	0.9742	1	1	CCNA2/CDK4/DDX58/BCL2L11/PSMD2/RAC1/CIR1/CCNA1/MDM2/CHUK	10
KEGG	hsa04975	Fat digestion and absorption	1/669	43/8144	0.9752	1	1	PNLIPRP2	1
KEGG	hsa02010	ABC transporters	1/669	45/8144	0.9791	1	1	ABCB4	1
KEGG	hsa04066	HIF-1 signaling pathway	4/669	109/8144	0.9823	1	1	IFNGR1/HK2/IGF1/MAPK3	4
KEGG	hsa04973	Carbohydrate digestion and absorption	1/669	47/8144	0.9824	1	1	HK2	1
KEGG	hsa04630	JAK-STAT signaling pathway	7/669	162/8144	0.983	1	1	IFNGR1/SOCS7/GRB2/IL11/IL22RA2/STAM2/IL2	7
KEGG	hsa04970	Salivary secretion	3/669	93/8144	0.9854	1	1	ADRB2/ADCY8/GNAS	3
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	6/669	150/8144	0.9871	1	1	PPP2CA/ADRB2/ADCY8/GNAS/CACNG8/MAPK3	6
KEGG	hsa05320	Autoimmune thyroid disease	1/669	53/8144	0.9895	1	1	IL2	1
KEGG	hsa04925	Aldosterone synthesis and secretion	3/669	98/8144	0.9896	1	1	ADCY8/GNAS/ORAI1	3
KEGG	hsa04080	Neuroactive ligand-receptor interaction	19/669	362/8144	0.9898	1	1	NMB/GRIN2C/P2RY1/THRB/GAL/TRPV1/LPAR4/MC5R/ADRB2/GLP1R/GABRA4/VGF/ADRA2A/DRD2/ADORA3/EDN3/GALR2/LYPD6/GABRA1	19
KEGG	hsa04929	GnRH secretion	1/669	64/8144	0.9959	1	1	MAPK3	1
KEGG	hsa05150	Staphylococcus aureus infection	2/669	96/8144	0.9975	1	1	KRT14/C1QA	2
KEGG	hsa04020	Calcium signaling pathway	9/669	240/8144	0.9984	1	1	GRIN2C/SLC25A4/ADRB2/ADCY8/CXCR4/GNAS/VDAC3/KDR/ORAI1	9
KEGG	hsa04613	Neutrophil extracellular trap formation	6/669	190/8144	0.9988	1	1	ACTG1/SLC25A4/RAC1/VDAC3/CYBA/MAPK3	6
KEGG	hsa05322	Systemic lupus erythematosus	3/669	136/8144	0.9993	1	1	SNRPD3/C8G/C1QA	3
KEGG	hsa05152	Tuberculosis	4/669	180/8144	0.9999	1	1	IFNGR1/PLA2R1/ATP6AP1/MAPK3	4
KEGG	hsa04740	Olfactory transduction	16/669	440/8144	1	1	1	OR2A25/OR2T2/OR52H1/OR5AC2/OR6C76/OR52N5/OR12D2/OR6C68/OR2AG1/GNG13/OR10G8/OR5M1/OR52W1/OR4K17/OR3A3/OR4M2	16