ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04660 T cell receptor signaling pathway 23/801 104/8144 0.0001491 0.04877 0.04804 CD3D/TNF/PTPN6/CD3G/FYN/CD28/CTLA4/PPP3CC/PDCD1/GRB2/PAK1/CDC42/IFNG/CBLB/LAT/PLCG1/CD4/ICOS/CD247/SOS2/PTPRC/TEC/PPP3CB 23 KEGG hsa05340 Primary immunodeficiency 11/801 38/8144 0.0007768 0.09323 0.09184 CD3D/TNFRSF13C/CIITA/AICDA/RAG1/RFXAP/ORAI1/RFX5/CD4/ICOS/PTPRC 11 KEGG hsa04650 Natural killer cell mediated cytotoxicity 25/801 131/8144 0.0008553 0.09323 0.09184 TNF/CD48/PTPN6/IFNA1/TNFRSF10B/BID/CASP3/FYN/CD244/PPP3CC/IFNA13/IFNAR1/GRB2/PAK1/IFNG/LAT/NCR2/FASLG/GZMB/PLCG1/BRAF/CD247/SOS2/PPP3CB/ULBP1 25 KEGG hsa05152 Tuberculosis 31/801 180/8144 0.001329 0.1087 0.107 TNF/HLA-DRA/CORO1A/ATP6V0D2/CAMK2G/IFNA1/CIITA/FCGR2B/IL10RA/BID/CASP3/IL23A/RFXAP/TGFB2/NFYA/PPP3CC/TLR4/IFNA13/RFX5/LBP/IFNG/CR1/IL1A/CLEC4M/ATP6V0B/BCL2/CREBBP/ARHGEF12/HSPA9/PPP3CB/SPHK1 31 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 18/801 100/8144 0.008123 0.4556 0.4488 TNF/CCL8/CSF1R/CCL3/TNFRSF10B/IL10RA/PPBP/CCL22/CCL14/IL24/PF4V1/CCL15/CCR6/XCL1/CCR5/CCL19/CCL24/CCL23 18 KEGG hsa04520 Adherens junction 14/801 71/8144 0.00836 0.4556 0.4488 PTPN6/PTPN1/FYN/LEF1/WASF2/CDC42/PTPRB/WASF3/FGFR1/CREBBP/CDH1/TCF7/TGFBR2/INSR 14 KEGG hsa05130 Pathogenic Escherichia coli infection 30/801 197/8144 0.009969 0.4657 0.4587 TNF/OCLN/PTPN6/WIPF2/LPAR5/TNFRSF10B/CASP3/FYN/TLR4/ACTR3C/GNA12/PAK1/WASF2/CDC42/WASF3/MYO1G/WIPF1/FASLG/ARHGEF2/CLDN19/MYO1D/CYTH1/TUBB8/BRK1/CLDN1/NCL/MYO1C/ARHGEF12/SLC9A3R1/CLDN17 30 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 16/801 89/8144 0.01231 0.4954 0.488 CD3D/PTPN6/CD3G/ALK/CD28/PPP3CC/TLR4/RPS6KB2/PDCD1/IFNG/LAT/PLCG1/STAT3/CD4/CD247/PPP3CB 16 KEGG hsa04640 Hematopoietic cell lineage 17/801 99/8144 0.01564 0.4954 0.488 CD3D/TNF/CD1E/CD33/CSF1R/HLA-DRA/CD3G/CD1A/CD1C/MS4A1/CD2/ANPEP/CD34/CR1/IL1A/CD4/KIT 17 KEGG hsa05205 Proteoglycans in cancer 30/801 205/8144 0.01696 0.4954 0.488 TNF/WNT8A/PTPN6/CAMK2G/TIMP3/CASP3/TGFB2/WNT6/TLR4/RPS6KB2/SDC1/PPP1CA/GRB2/PAK1/CDC42/COL1A1/PDCD4/ANK1/SLC9A1/FASLG/PLCG1/DCN/STAT3/MIR10A/MIR10B/FGFR1/BRAF/SOS2/ARHGEF12/MMP2 30 KEGG hsa05323 Rheumatoid arthritis 16/801 93/8144 0.01836 0.4954 0.488 TNF/TEK/HLA-DRA/ATP6V0D2/CCL3/IL17A/IL23A/TGFB2/CD28/CTLA4/TLR4/IFNG/IL1A/ATP6V0B/MMP3/CD80 16 KEGG hsa04514 Cell adhesion molecules 23/801 149/8144 0.01915 0.4954 0.488 OCLN/HLA-DRA/CD6/MPZ/CD2/NCAM1/CD28/CTLA4/CNTN2/SDC1/PDCD1/CD34/SELP/CLDN19/CD4/ICOS/CDH1/CD80/CLDN1/PTPRC/ITGB7/CLDN17/CD58 23 KEGG hsa04392 Hippo signaling pathway - multiple species 7/801 29/8144 0.0197 0.4954 0.488 STK3/RASSF2/PAK1/FRMD6/LATS1/WWTR1/SAV1 7 KEGG hsa04060 Cytokine-cytokine receptor interaction 40/801 295/8144 0.02181 0.5095 0.5019 TNF/CCL8/CSF1R/IL16/TNFRSF13C/CCL3/TNFRSF17/BMP10/IFNA1/TNFRSF9/TNFRSF10B/IL10RA/IL17A/GH2/PPBP/IL23A/TGFB2/CCL22/CCL14/TNFSF4/IL24/IFNA13/IFNAR1/PF4V1/IFNG/IL1A/CCL15/CCR6/XCL1/PRLR/FASLG/CCR5/CD4/NGFR/CCL19/OSMR/TGFBR2/CCL24/CCL23/ACVR2A 40 KEGG hsa04666 Fc gamma R-mediated phagocytosis 16/801 97/8144 0.02648 0.5773 0.5686 ASAP2/FCGR2B/INPP5D/RPS6KB2/ACTR3C/PAK1/WASF2/CDC42/INPPL1/WASF3/LAT/PRKCE/AMPH/PLCG1/PTPRC/SPHK1 16 KEGG hsa04010 MAPK signaling pathway 39/801 294/8144 0.03176 0.6491 0.6394 TNF/TEK/CSF1R/DUSP10/PPM1A/FGFR2/MAP3K1/CASP3/STK3/FGF23/TGFB2/HSPA1B/DDIT3/ECSIT/PPP3CC/GNA12/MAPT/GRB2/PAK1/CDC42/MAP4K4/IL1A/ANGPT2/CACNA2D4/FASLG/FGFR1/BRAF/NGFR/CACNA2D3/CACNA1B/KIT/SOS2/PDGFRB/FGFR4/CACNA1C/TAOK3/TGFBR2/INSR/PPP3CB 39 KEGG hsa04972 Pancreatic secretion 16/801 102/8144 0.04007 0.748 0.7368 SLC4A4/ATP2B1/PLA2G2D/CPB1/TRPC1/SCTR/PRSS1/RYR2/ATP1B1/PNLIPRP1/CPA3/ATP1A1/ATP1B2/SLC9A1/ADCY6/CPA2 16 KEGG hsa04380 Osteoclast differentiation 19/801 128/8144 0.04434 0.748 0.7368 TNF/LILRA4/CSF1R/FOSL1/FCGR2B/FYN/TGFB2/SPI1/PPP3CC/LILRA2/IFNAR1/GRB2/IFNG/IL1A/CYBA/LILRB5/TGFBR2/TEC/PPP3CB 19 KEGG hsa04672 Intestinal immune network for IgA production 9/801 49/8144 0.04698 0.748 0.7368 HLA-DRA/TNFRSF13C/TNFRSF17/AICDA/CD28/PIGR/ICOS/CD80/ITGB7 9 KEGG hsa05417 Lipid and atherosclerosis 29/801 215/8144 0.0485 0.748 0.7368 TNF/MIB1/CCL3/CAMK2G/IFNA1/POU2F3/TNFRSF10B/BID/CASP3/HSPA1B/DDIT3/APOB/PPP3CC/TLR4/IFNA13/CDC42/LBP/SELP/CYBA/FASLG/PLCG1/STAT3/CYP2A7/BCL2/MMP3/XBP1/ABCG1/CYP2B6/PPP3CB 29 KEGG hsa05332 Graft-versus-host disease 8/801 42/8144 0.04926 0.748 0.7368 TNF/HLA-DRA/CD28/IFNG/IL1A/FASLG/GZMB/CD80 8 KEGG hsa05162 Measles 20/801 139/8144 0.05257 0.748 0.7368 CD3D/CD3G/IFNA1/FCGR2B/BID/CASP3/HSPA1B/CD28/TLR4/IFNA13/IFNAR1/CBLB/IL1A/CLEC4M/CCND2/CDK6/FASLG/STAT3/BCL2/OAS3 20 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 4/801 15/8144 0.05261 0.748 0.7368 ST6GALNAC5/GLB1/B3GALT4/HEXA 4 KEGG hsa04940 Type I diabetes mellitus 8/801 43/8144 0.05553 0.7566 0.7452 TNF/HLA-DRA/CD28/IFNG/IL1A/FASLG/GZMB/CD80 8 KEGG hsa05221 Acute myeloid leukemia 11/801 67/8144 0.06096 0.7678 0.7563 CSF1R/SPI1/PPARD/RPS6KB2/LEF1/GRB2/STAT3/BRAF/KIT/TCF7/SOS2 11 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 21/801 150/8144 0.06105 0.7678 0.7563 TPM3/ATP2B1/PIK3CG/RAPGEF4/CAMK2G/CREM/PPP1CA/RYR2/TPM4/PPP2R3A/ATP1B1/PPP2R5C/ATP1A1/PLN/CACNA2D4/ATP1B2/SLC9A1/BCL2/CACNA2D3/ADCY6/CACNA1C 21 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 9/801 53/8144 0.0716 0.7756 0.764 ATP2B1/TRPV5/ATP1B1/CLTB/ATP1A1/ATP1B2/KLK1/ADCY6/AP2A2 9 KEGG hsa05320 Autoimmune thyroid disease 9/801 53/8144 0.0716 0.7756 0.764 HLA-DRA/IFNA1/CD28/CTLA4/IFNA13/FASLG/GZMB/CD80/TG 9 KEGG hsa05330 Allograft rejection 7/801 38/8144 0.07406 0.7756 0.764 TNF/HLA-DRA/CD28/IFNG/FASLG/GZMB/CD80 7 KEGG hsa04350 TGF-beta signaling pathway 14/801 94/8144 0.0749 0.7756 0.764 TNF/GREM1/TGFB2/RPS6KB2/IFNG/NBL1/SMURF2/DCN/LEFTY2/FST/CREBBP/E2F5/TGFBR2/ACVR2A 14 KEGG hsa04930 Type II diabetes mellitus 8/801 46/8144 0.07728 0.7756 0.764 TNF/SOCS2/ABCC8/PRKCE/ADIPOQ/CACNA1B/CACNA1C/INSR 8 KEGG hsa05145 Toxoplasmosis 16/801 112/8144 0.08098 0.7756 0.764 TNF/HLA-DRA/PIK3CG/CIITA/IL10RA/CASP3/TGFB2/HSPA1B/TLR4/LAMB1/IFNG/LAMA3/STAT3/CCR5/BCL2/GNAO1 16 KEGG hsa04260 Cardiac muscle contraction 13/801 87/8144 0.08226 0.7756 0.764 TRDN/TPM3/COX7A2/RYR2/TPM4/ATP1B1/CASQ2/ATP1A1/CACNA2D4/ATP1B2/SLC9A1/CACNA2D3/CACNA1C 13 KEGG hsa03250 Viral life cycle - HIV-1 10/801 63/8144 0.08627 0.7756 0.764 NELFA/NELFCD/SAMHD1/CCR5/CD4/PIN1/SMARCB1/CREBBP/CCNT2/CCNT1 10 KEGG hsa04062 Chemokine signaling pathway 25/801 192/8144 0.08784 0.7756 0.764 CCL8/PIK3CG/CCL3/PPBP/CCL22/GNGT2/CCL14/DOCK2/PF4V1/GRB2/PAK1/CDC42/CCL15/CCR6/XCL1/PLCG1/STAT3/CCR5/BRAF/SOS2/CCL19/ADCY6/CCL24/GSK3A/CCL23 25 KEGG hsa05160 Hepatitis C 21/801 157/8144 0.08942 0.7756 0.764 TNF/OCLN/IFNA1/BID/CASP3/YWHAZ/IFNA13/IFNAR1/GRB2/IFNG/YWHAG/CDK6/FASLG/STAT3/CLDN19/BRAF/NR1H3/CLDN1/SOS2/OAS3/CLDN17 21 KEGG hsa05215 Prostate cancer 14/801 97/8144 0.09185 0.7756 0.764 FGFR2/LEF1/GRB2/TMPRSS2/FGFR1/BRAF/BCL2/CREBBP/MMP3/TCF7/ZEB1/SOS2/PDGFRB/SRD5A2 14 KEGG hsa00280 Valine, leucine and isoleucine degradation 8/801 48/8144 0.09425 0.7756 0.764 AOX1/ALDH7A1/OXCT1/AUH/IL4I1/HIBADH/ACAA2/ALDH3A2 8 KEGG hsa04340 Hedgehog signaling pathway 9/801 56/8144 0.09449 0.7756 0.764 SCUBE2/CSNK1D/HHAT/SUFU/CCND2/CSNK1A1L/SMURF2/GPR161/BCL2 9 KEGG hsa04310 Wnt signaling pathway 22/801 167/8144 0.09487 0.7756 0.764 LGR5/WNT8A/CAMK2G/FOSL1/CTBP2/PPP3CC/WNT6/PPARD/PRICKLE4/LEF1/ROR1/MMP7/CCND2/CSNK1A1L/LGR6/SFRP5/CER1/CREBBP/AXIN1/TCF7/PPP3CB/VANGL2 22 KEGG hsa05225 Hepatocellular carcinoma 22/801 168/8144 0.09957 0.7907 0.7788 GSTO2/SMARCC2/WNT8A/TGFB2/WNT6/RPS6KB2/LEF1/GRB2/GSTT2B/MGST1/DPF3/CSNK1A1L/CDK6/PLCG1/BRAF/SMARCB1/AXIN1/TCF7/SOS2/TGFBR2/SMARCC1/SMARCD2 22 KEGG hsa05321 Inflammatory bowel disease 10/801 65/8144 0.1016 0.7907 0.7788 TNF/HLA-DRA/IL17A/IL23A/TGFB2/TLR4/IFNG/IL1A/STAT6/STAT3 10 KEGG hsa04659 Th17 cell differentiation 15/801 108/8144 0.107 0.8136 0.8015 CD3D/HLA-DRA/CD3G/IL17A/IL23A/PPP3CC/IFNG/LAT/STAT6/PLCG1/STAT3/CD4/CD247/TGFBR2/PPP3CB 15 KEGG hsa04630 JAK-STAT signaling pathway 21/801 162/8144 0.1142 0.8366 0.824 AOX1/PTPN6/IFNA1/IL10RA/GH2/IL23A/IL24/IFNA13/IFNAR1/GRB2/SOCS2/IFNG/CCND2/PRLR/STAT6/STAT3/BCL2/CREBBP/SOS2/PDGFRB/OSMR 21 KEGG hsa04658 Th1 and Th2 cell differentiation 13/801 92/8144 0.1151 0.8366 0.824 CD3D/RUNX3/HLA-DRA/RBPJ/CD3G/PPP3CC/IFNG/LAT/STAT6/PLCG1/CD4/CD247/PPP3CB 13 KEGG hsa04740 Olfactory transduction 51/801 440/8144 0.1186 0.843 0.8303 OR51V1/OR7E24/OR2A14/CAMK2G/OR6B1/OR5B21/OR1F1/OR10Z1/OR56A1/OR10G8/OR12D2/OR51D1/OR13C4/OR5AN1/OR51I2/OR1Q1/OR5K1/OR2T33/OR5F1/OR51M1/OR6A2/OR2AG1/OR2L2/OR2T8/OR2L3/OR2Z1/OR2C3/OR2G3/OR9A2/OR52N1/OR1B1/OR8K1/OR2D3/ANO2/OR52R1/OR51B5/OR2T12/OR52B6/OR52K1/OR10A2/OR6C74/OR5AU1/OR51A7/OR6C76/OR56A3/OR5D13/OR2K2/OR5D16/OR8D4/OR2AT4/OR4D6 51 KEGG hsa04978 Mineral absorption 9/801 60/8144 0.1309 0.9105 0.8969 ATP2B1/TRPM7/ATP1B1/SLC26A9/ATP1A1/HEPHL1/ATP1B2/CLCN2/MT2A 9 KEGG hsa04911 Insulin secretion 12/801 86/8144 0.1354 0.9136 0.8999 RAPGEF4/CAMK2G/KCNMB1/RYR2/GCG/ATP1B1/ABCC8/KCNU1/ATP1A1/ATP1B2/ADCY6/CACNA1C 12 KEGG hsa00760 Nicotinate and nicotinamide metabolism 6/801 36/8144 0.1369 0.9136 0.8999 PNP/AOX1/ENPP3/NMNAT3/NT5M/NT5C 6 KEGG hsa04068 FoxO signaling pathway 17/801 131/8144 0.143 0.9355 0.9215 HOMER2/SETD7/RAG1/CCNG2/TGFB2/PRKAG1/GRB2/FBXO25/CDKN2D/CCND2/FASLG/STAT3/BRAF/CREBBP/SOS2/TGFBR2/INSR 17 KEGG hsa05414 Dilated cardiomyopathy 13/801 96/8144 0.1462 0.9374 0.9233 TNF/TPM3/ITGA11/TGFB2/SGCB/RYR2/TPM4/PLN/CACNA2D4/CACNA2D3/ADCY6/ITGB7/CACNA1C 13 KEGG hsa04120 Ubiquitin mediated proteolysis 18/801 142/8144 0.1571 0.9882 0.9734 UBE2F/TRIM32/UBE2W/MAP3K1/SAE1/UBE4B/UBE2D3/CBLB/CBLC/SMURF2/UBE2N/ANAPC5/UBE4A/UBE2U/RHOBTB1/HERC1/UBE2L6/FANCL 18 KEGG hsa00340 Histidine metabolism 4/801 22/8144 0.1645 0.9995 0.9846 ALDH7A1/HNMT/ALDH3A2/ALDH3A1 4 KEGG hsa05410 Hypertrophic cardiomyopathy 12/801 90/8144 0.171 0.9995 0.9846 TNF/TPM3/ITGA11/TGFB2/SGCB/PRKAG1/RYR2/TPM4/CACNA2D4/CACNA2D3/ITGB7/CACNA1C 12 KEGG hsa04110 Cell cycle 16/801 126/8144 0.1728 0.9995 0.9846 MCM2/TGFB2/ORC2/YWHAZ/TTK/CDKN2D/CCND2/WEE2/YWHAG/CDK6/CCNH/ANAPC5/CREBBP/E2F5/RAD21/CDC7 16 KEGG hsa04662 B cell receptor signaling pathway 11/801 82/8144 0.1792 0.9995 0.9846 LILRA4/PTPN6/FCGR2B/INPP5D/PPP3CC/LILRA2/GRB2/INPPL1/LILRB5/SOS2/PPP3CB 11 KEGG hsa04964 Proximal tubule bicarbonate reclamation 4/801 23/8144 0.1847 0.9995 0.9846 SLC4A4/ATP1B1/ATP1A1/ATP1B2 4 KEGG hsa04215 Apoptosis - multiple species 5/801 32/8144 0.2016 0.9995 0.9846 BID/CASP3/DIABLO/NGFR/BCL2 5 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 7/801 49/8144 0.2024 0.9995 0.9846 PMM1/CHIA/CYB5RL/UAP1/GNE/GNPDA1/HEXA 7 KEGG hsa00565 Ether lipid metabolism 7/801 49/8144 0.2024 0.9995 0.9846 PLA2G2D/ENPP6/PLD3/LPCAT4/GDPD1/LPCAT2/PLD4 7 KEGG hsa04072 Phospholipase D signaling pathway 18/801 148/8144 0.2026 0.9995 0.9846 PIK3CG/RAPGEF4/LPAR5/FYN/GNA12/GRB2/TSC1/DGKH/GRM8/PLCG1/CYTH1/GRM4/KIT/SOS2/PDGFRB/ADCY6/INSR/SPHK1 18 KEGG hsa00360 Phenylalanine metabolism 3/801 16/8144 0.2036 0.9995 0.9846 IL4I1/ALDH3A1/TAT 3 KEGG hsa05213 Endometrial cancer 8/801 58/8144 0.2067 0.9995 0.9846 LEF1/GRB2/ILK/BRAF/AXIN1/CDH1/TCF7/SOS2 8 KEGG hsa05144 Malaria 7/801 50/8144 0.217 0.9995 0.9846 TNF/TGFB2/TLR4/SDC1/IFNG/SELP/CR1 7 KEGG hsa03410 Base excision repair 5/801 33/8144 0.2199 0.9995 0.9846 NTHL1/PARP1/POLE4/LIG3/SMUG1 5 KEGG hsa05210 Colorectal cancer 11/801 86/8144 0.2221 0.9995 0.9846 CASP3/TGFB2/RPS6KB2/LEF1/GRB2/BRAF/BCL2/AXIN1/TCF7/SOS2/TGFBR2 11 KEGG hsa05140 Leishmaniasis 10/801 77/8144 0.2223 0.9995 0.9846 TNF/HLA-DRA/PTPN6/TGFB2/TLR4/EEF1A1/IFNG/CR1/IL1A/CYBA 10 KEGG hsa00380 Tryptophan metabolism 6/801 42/8144 0.2276 0.9995 0.9846 AOX1/IDO1/ALDH7A1/IL4I1/CYP1A2/ALDH3A2 6 KEGG hsa04724 Glutamatergic synapse 14/801 114/8144 0.2283 0.9995 0.9846 HOMER2/GNGT2/TRPC1/PPP3CC/SLC1A2/GRM8/SLC38A2/GRIK4/GRM4/ADCY6/CACNA1C/SHANK2/PPP3CB/GNAO1 14 KEGG hsa04936 Alcoholic liver disease 17/801 142/8144 0.2302 0.9995 0.9846 TNF/IFNA1/C3AR1/CASP3/IL17A/ALDH7A1/TLR4/PRKAG1/IFNA13/LEF1/LBP/TRA2B/FASLG/ADIPOQ/ADIPOR1/ALDH3A2/TCF7 17 KEGG hsa00450 Selenocompound metabolism 3/801 17/8144 0.2304 0.9995 0.9846 SEPHS1/SEPHS2/PSTK 3 KEGG hsa05416 Viral myocarditis 8/801 60/8144 0.2339 0.9995 0.9846 HLA-DRA/BID/CASP3/FYN/CD28/SGCB/EIF4G2/CD80 8 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 10/801 78/8144 0.2343 0.9995 0.9846 GSTO2/EPHX1/GSTT2B/MGST1/DHDH/CYP1A2/CYP2A7/CYP2S1/ALDH3A1/CYP2B6 10 KEGG hsa05211 Renal cell carcinoma 9/801 69/8144 0.2346 0.9995 0.9846 TGFB2/ARNT/GRB2/PAK1/CDC42/ARNT2/BRAF/CREBBP/SOS2 9 KEGG hsa05161 Hepatitis B 19/801 162/8144 0.2412 0.9995 0.9846 TNF/IFNA1/BID/MAP3K1/CASP3/TGFB2/YWHAZ/TLR4/IFNA13/IFNAR1/GRB2/STAT6/FASLG/STAT3/BRAF/BCL2/CREBBP/SOS2/TGFBR2 19 KEGG hsa00564 Glycerophospholipid metabolism 12/801 98/8144 0.254 0.9995 0.9846 PLA2G2D/LYPLA2/CHKA/PLD3/DGKH/LPCAT4/PTDSS2/CDS1/LPCAT2/PLD4/PNPLA7/CDS2 12 KEGG hsa04976 Bile secretion 11/801 89/8144 0.2566 0.9995 0.9846 SLC4A4/EPHX1/SCTR/ATP1B1/ATP1A1/ABCG2/ATP1B2/SLC9A1/ABCB4/SLC22A7/ADCY6 11 KEGG hsa00511 Other glycan degradation 3/801 18/8144 0.2578 0.9995 0.9846 GLB1/NEU4/HEXA 3 KEGG hsa00600 Sphingolipid metabolism 7/801 53/8144 0.2626 0.9995 0.9846 PSAPL1/GLB1/SGPL1/NEU4/SMPD3/HEXA/SPHK1 7 KEGG hsa04144 Endocytosis 28/801 251/8144 0.2667 0.9995 0.9846 RAB11FIP1/ASAP2/RNF41/WIPF2/FGFR2/HSPA1B/SH3GLB1/CHMP3/ACTR3C/CDC42/CLTB/MVB12B/CBLB/WIPF1/VPS29/AMPH/CBLC/SMURF2/CCR5/SH3GLB2/CYTH1/SH3GL3/LDLRAP1/FGFR4/VPS36/TGFBR2/EHD4/AP2A2 28 KEGG hsa04910 Insulin signaling pathway 16/801 137/8144 0.2708 0.9995 0.9846 PTPN1/PRKAR2B/RHOQ/RPS6KB2/PRKAG1/PPP1CA/GRB2/TSC1/SOCS2/INPPL1/FLOT1/CBLB/BRAF/SOS2/PRKAR1A/INSR 16 KEGG hsa00062 Fatty acid elongation 4/801 27/8144 0.2717 0.9995 0.9846 ELOVL1/ELOVL3/ACAA2/ELOVL4 4 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 12/801 100/8144 0.2768 0.9995 0.9846 TNF/CASP3/TGFB2/CDC42/COL1A1/IL1A/PRKCE/PLCG1/STAT3/BCL2/MMP2/TGFBR2 12 KEGG hsa00350 Tyrosine metabolism 5/801 36/8144 0.2772 0.9995 0.9846 AOX1/LRTOMT/IL4I1/ALDH3A1/TAT 5 KEGG hsa02010 ABC transporters 6/801 45/8144 0.2788 0.9995 0.9846 ABCC8/ABCG2/ABCB9/ABCB4/ABCA4/ABCG1 6 KEGG hsa04390 Hippo signaling pathway 18/801 157/8144 0.2806 0.9995 0.9846 WNT8A/CSNK1D/STK3/TGFB2/YWHAZ/WNT6/PPP1CA/LEF1/FRMD6/CCND2/LATS1/YWHAG/AXIN1/CDH1/TCF7/WWTR1/TGFBR2/SAV1 18 KEGG hsa04080 Neuroactive ligand-receptor interaction 39/801 362/8144 0.295 0.9995 0.9846 TAAR5/OPRL1/CHRNB3/TRHR/C3AR1/NMB/GHRH/GH2/OPRM1/RXFP3/PTH2R/PNOC/SSTR2/SCTR/HTR1B/EDN3/CRHR2/PRSS1/PTAFR/NMBR/GCG/P2RY11/GRM8/CORT/PRLR/FPR3/TAAR1/P2RX3/INSL5/RXFP1/GRIK4/GRM4/CALCA/NPBWR2/QRFPR/NTSR1/NPFF/HRH4/TAAR8 39 KEGG hsa05226 Gastric cancer 17/801 149/8144 0.2951 0.9995 0.9846 WNT8A/FGFR2/FGF23/TGFB2/WNT6/RPS6KB2/LEF1/GRB2/REG4/CSNK1A1L/BRAF/BCL2/AXIN1/CDH1/TCF7/SOS2/TGFBR2 17 KEGG hsa05216 Thyroid cancer 5/801 37/8144 0.297 0.9995 0.9846 TPM3/LEF1/BRAF/CDH1/TCF7 5 KEGG hsa05146 Amoebiasis 12/801 102/8144 0.3001 0.9995 0.9846 TNF/CD1E/CD1A/CD1C/CASP3/TGFB2/TLR4/SERPINB13/LAMB1/IFNG/LAMA3/COL1A1 12 KEGG hsa04114 Oocyte meiosis 15/801 131/8144 0.306 0.9995 0.9846 STAG3/CAMK2G/FBXO43/YWHAZ/PPP3CC/SLK/PPP1CA/CPEB4/PPP2R5C/PLCZ1/FBXO5/YWHAG/ANAPC5/ADCY6/PPP3CB 15 KEGG hsa04151 PI3K-Akt signaling pathway 38/801 354/8144 0.3063 0.9995 0.9846 TEK/CSF1R/PIK3CG/IFNA1/FGFR2/LPAR5/FGF23/GH2/ITGA11/GNGT2/YWHAZ/TLR4/RPS6KB2/IFNA13/LAMB1/IFNAR1/GRB2/TSC1/PPP2R3A/PPP2R5C/LAMA3/COL1A1/CCND2/PRLR/ANGPT2/YWHAG/CDK6/FASLG/FGFR1/NGFR/BCL2/KIT/SOS2/PDGFRB/ITGB7/FGFR4/OSMR/INSR 38 KEGG hsa04974 Protein digestion and absorption 12/801 103/8144 0.312 0.9995 0.9846 SLC36A1/CPB1/PRSS1/ATP1B1/COL17A1/COL1A1/CPA3/SLC38A2/ATP1A1/ATP1B2/SLC1A5/CPA2 12 KEGG hsa03320 PPAR signaling pathway 9/801 75/8144 0.316 0.9995 0.9846 FABP2/GK2/PPARD/ACSL3/ILK/ADIPOQ/FABP4/FABP3/NR1H3 9 KEGG hsa04142 Lysosome 15/801 132/8144 0.3165 0.9995 0.9846 ATP6V0D2/PSAPL1/SUMF1/GLB1/SLC17A5/GGA3/CTSE/GGA1/CLTB/AP3M2/ATP6V0B/ABCB9/DMXL1/HEXA/CLN5 15 KEGG hsa05164 Influenza A 19/801 171/8144 0.3216 0.9995 0.9846 TNF/HLA-DRA/IFNA1/CIITA/TNFRSF10B/CPSF4L/BID/CASP3/TLR4/IFNA13/PRSS1/IFNAR1/IFNG/IL1A/CDK6/FASLG/TMPRSS2/CREBBP/OAS3 19 KEGG hsa05134 Legionellosis 7/801 57/8144 0.327 0.9995 0.9846 TNF/CASP3/HSPA1B/TLR4/EEF1A1/CR1/CLK4 7 KEGG hsa04742 Taste transduction 10/801 86/8144 0.3373 0.9995 0.9846 CALHM1/TAS2R3/HTR3A/HTR1B/TAS2R38/P2RX3/TAS1R1/GRM4/ADCY6/CACNA1C 10 KEGG hsa05206 MicroRNAs in cancer 33/801 310/8144 0.3405 0.9995 0.9846 MIR30C1/MIRLET7B/TIMP3/MIR137/CASP3/ZEB2/TGFB2/MIR133A1/MIRLET7A3/MIR126/GRB2/MIR133B/KIF23/PDCD4/MIRLET7F1/CCND2/MIR181A2/PRKCE/CDK6/PLCG1/STAT3/DNMT3A/MIR10A/MIR10B/TRIM71/MIR152/BCL2/CREBBP/TP63/ZEB1/SOS2/PDGFRB/RECK 33 KEGG hsa00770 Pantothenate and CoA biosynthesis 3/801 21/8144 0.3417 0.9995 0.9846 ENPP3/ALDH3A2/COASY 3 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 9/801 77/8144 0.3445 0.9995 0.9846 ITGA11/SGCB/LEF1/RYR2/CACNA2D4/CACNA2D3/TCF7/ITGB7/CACNA1C 9 KEGG hsa04932 Non-alcoholic fatty liver disease 17/801 155/8144 0.3547 0.9995 0.9846 TNF/NDUFS2/BID/CASP3/DDIT3/COX7A2/PRKAG1/CDC42/IL1A/FASLG/ADIPOQ/ADIPOR1/NR1H3/XBP1/NDUFB7/INSR/GSK3A 17 KEGG hsa04070 Phosphatidylinositol signaling system 11/801 97/8144 0.3561 0.9995 0.9846 INPP5D/DGKH/INPPL1/PLCZ1/IP6K2/PLCG1/MTMR14/CDS1/INPP1/ITPKA/CDS2 11 KEGG hsa00260 Glycine, serine and threonine metabolism 5/801 40/8144 0.3574 0.9995 0.9846 GCSH/ALDH7A1/BPGM/SARDH/BHMT 5 KEGG hsa04612 Antigen processing and presentation 9/801 78/8144 0.3589 0.9995 0.9846 TNF/HLA-DRA/CIITA/RFXAP/HSPA1B/NFYA/RFX5/IFNG/CD4 9 KEGG hsa04721 Synaptic vesicle cycle 9/801 78/8144 0.3589 0.9995 0.9846 ATP6V0D2/STX3/SLC6A4/SLC1A2/CLTB/ATP6V0B/CACNA1B/AP2A2/CPLX4 9 KEGG hsa04925 Aldosterone synthesis and secretion 11/801 98/8144 0.369 0.9995 0.9846 ATP2B1/CAMK2G/CYP11B2/DAGLB/ORAI1/ATP1B1/ATP1A1/PRKCE/ATP1B2/ADCY6/CACNA1C 11 KEGG hsa05231 Choline metabolism in cancer 11/801 98/8144 0.369 0.9995 0.9846 CHKA/SLC22A2/RPS6KB2/GRB2/TSC1/WASF2/DGKH/WASF3/PLCG1/SOS2/PDGFRB 11 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 9/801 79/8144 0.3733 0.9995 0.9846 FGFR2/RPS6KB2/GRB2/PLCG1/STAT3/BRAF/BCL2/SOS2/PDGFRB 9 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 8/801 70/8144 0.3829 0.9995 0.9846 ATP6V0D2/CSK/CASP3/PAK1/CDC42/PTPRZ1/ATP6V0B/PLCG1 8 KEGG hsa04066 HIF-1 signaling pathway 12/801 109/8144 0.3852 0.9995 0.9846 TEK/CAMK2G/TLR4/RPS6KB2/ARNT/IFNG/ANGPT2/PLCG1/STAT3/BCL2/CREBBP/INSR 12 KEGG hsa00270 Cysteine and methionine metabolism 6/801 51/8144 0.3868 0.9995 0.9846 CDO1/MAT1A/IL4I1/DNMT3A/BHMT/TAT 6 KEGG hsa00140 Steroid hormone biosynthesis 7/801 61/8144 0.3934 0.9995 0.9846 HSD17B6/CYP11B2/LRTOMT/AKR1D1/CYP1A2/HSD17B3/SRD5A2 7 KEGG hsa00561 Glycerolipid metabolism 7/801 61/8144 0.3934 0.9995 0.9846 GK2/AKR1A1/ALDH7A1/DGKH/PNLIPRP1/ALDH3A2/AKR1B1 7 KEGG hsa04217 Necroptosis 17/801 159/8144 0.3957 0.9995 0.9846 TNF/PARP1/CAMK2G/IFNA1/TNFRSF10B/BID/TLR4/CHMP3/IFNA13/IFNAR1/TRPM7/IFNG/IL1A/STAT6/FASLG/STAT3/BCL2 17 KEGG hsa04614 Renin-angiotensin system 3/801 23/8144 0.3975 0.9995 0.9846 ANPEP/CPA3/KLK1 3 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/801 14/8144 0.407 0.9995 0.9846 B3GNT7/CHST4 2 KEGG hsa04130 SNARE interactions in vesicular transport 4/801 33/8144 0.4104 0.9995 0.9846 STX3/STX11/YKT6/STX16 4 KEGG hsa04020 Calcium signaling pathway 25/801 240/8144 0.4116 0.9995 0.9846 TRDN/ATP2B1/CAMK2G/FGFR2/TRHR/FGF23/PPP3CC/ORAI1/RYR2/PTAFR/PLCZ1/CASQ2/PLN/PLCG1/P2RX3/FGFR1/CACNA1B/RYR1/ITPKA/PDGFRB/FGFR4/CACNA1C/NTSR1/PPP3CB/SPHK1 25 KEGG hsa00982 Drug metabolism - cytochrome P450 8/801 72/8144 0.4139 0.9995 0.9846 GSTO2/AOX1/GSTT2B/MGST1/CYP1A2/CYP2A7/ALDH3A1/CYP2B6 8 KEGG hsa04024 cAMP signaling pathway 23/801 221/8144 0.4196 0.9995 0.9846 ATP2B1/RAPGEF4/CAMK2G/SUCNR1/ORAI1/SSTR2/HTR1B/EDN3/PPP1CA/CRHR2/RYR2/PAK1/GCG/ATP1B1/PDE4B/ATP1A1/PLN/ATP1B2/SLC9A1/BRAF/CREBBP/ADCY6/CACNA1C 23 KEGG hsa05165 Human papillomavirus infection 34/801 331/8144 0.4206 0.9995 0.9846 TNF/WNT8A/ATP6V0D2/RBPJ/IFNA1/TBPL2/CASP3/ITGA11/WNT6/RPS6KB2/IFNA13/LAMB1/IFNAR1/GRB2/TSC1/CDC42/PPP2R3A/HES3/PPP2R5C/LAMA3/COL1A1/CCND2/CSNK1A1L/CDK6/ATP6V0B/FASLG/MFNG/CREBBP/AXIN1/TCF7/SOS2/PDGFRB/ITGB7/SLC9A3R1 34 KEGG hsa05142 Chagas disease 11/801 102/8144 0.421 0.9995 0.9846 CD3D/TNF/CCL3/CD3G/TGFB2/TLR4/IFNG/FASLG/CD247/TGFBR2/GNAO1 11 KEGG hsa00310 Lysine degradation 7/801 63/8144 0.4268 0.9995 0.9846 SETD7/KMT2A/ALDH7A1/KMT2B/ALDH3A2/SETDB2/SETDB1 7 KEGG hsa05170 Human immunodeficiency virus 1 infection 22/801 212/8144 0.4283 0.9995 0.9846 CD3D/TNF/CD3G/IFNA1/BID/CASP3/GNGT2/PPP3CC/TLR4/RPS6KB2/IFNA13/PAK1/WEE2/SAMHD1/FASLG/PLCG1/CCR5/CD4/BCL2/CD247/PPP3CB/GNAO1 22 KEGG hsa04014 Ras signaling pathway 24/801 232/8144 0.4286 0.9995 0.9846 TEK/CSF1R/PLA2G2D/FGFR2/RASAL2/FGF23/GNGT2/SHOC2/GRB2/PAK1/CDC42/RAPGEF5/LAT/ANGPT2/RASAL1/FASLG/PLCG1/FGFR1/NGFR/KIT/SOS2/PDGFRB/FGFR4/INSR 24 KEGG hsa00562 Inositol phosphate metabolism 8/801 73/8144 0.4294 0.9995 0.9846 PIK3CG/INPP5D/INPPL1/PLCZ1/PLCG1/MTMR14/INPP1/ITPKA 8 KEGG hsa04115 p53 signaling pathway 8/801 73/8144 0.4294 0.9995 0.9846 TNFRSF10B/BID/CASP3/CCNG2/CCND2/CDK6/SIVA1/BCL2 8 KEGG hsa03020 RNA polymerase 4/801 34/8144 0.4333 0.9995 0.9846 TWISTNB/POLR2F/POLR1A/POLR3A 4 KEGG hsa00730 Thiamine metabolism 2/801 15/8144 0.4423 0.9995 0.9846 AK8/AK7 2 KEGG hsa04064 NF-kappa B signaling pathway 11/801 104/8144 0.4471 0.9995 0.9846 TNF/TRAF1/TNFRSF13C/PARP1/TLR4/LBP/LAT/PLCG1/BCL2/CCL19/ERC1 11 KEGG hsa03022 Basal transcription factors 5/801 45/8144 0.4581 0.9995 0.9846 TAF5/TBPL2/GTF2H3/CCNH/TAF8 5 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 11/801 106/8144 0.473 0.9995 0.9846 MEF2D/TRPV5/FGF23/GNA12/NACA/PDE4B/FGFR1/BRAF/BCL2/ADCY6/SLC9A3R1 11 KEGG hsa05150 Staphylococcus aureus infection 10/801 96/8144 0.4739 0.9995 0.9846 FGG/HLA-DRA/FCGR2B/C3AR1/PTAFR/FCAR/SELP/FPR3/MBL2/KRT31 10 KEGG hsa04971 Gastric acid secretion 8/801 76/8144 0.4755 0.9995 0.9846 KCNJ10/CAMK2G/SSTR2/ATP1B1/ATP1A1/ATP1B2/SLC9A1/ADCY6 8 KEGG hsa00512 Mucin type O-glycan biosynthesis 4/801 36/8144 0.4783 0.9995 0.9846 B3GNT6/GALNT18/GCNT3/C1GALT1C1L 4 KEGG hsa04022 cGMP-PKG signaling pathway 17/801 167/8144 0.4786 0.9995 0.9846 MEF2D/ATP2B1/PIK3CG/PPP3CC/KCNMB1/PPP1CA/GNA12/ATP1B1/KCNU1/ATP1A1/PLN/PRKCE/ATP1B2/ADCY6/CACNA1C/INSR/PPP3CB 17 KEGG hsa04810 Regulation of actin cytoskeleton 22/801 218/8144 0.4829 0.9995 0.9846 MYL12A/FGFR2/LPAR5/FGF23/ITGA11/ACTR3C/PPP1CA/GNA12/PAK1/WASF2/CDC42/SLC9A1/ARHGEF7/FGFR1/BRAF/IQGAP3/BRK1/SOS2/PDGFRB/ARHGEF12/ITGB7/FGFR4 22 KEGG hsa04720 Long-term potentiation 7/801 67/8144 0.4927 0.9995 0.9846 CAMK2G/PPP3CC/PPP1CA/BRAF/CREBBP/CACNA1C/PPP3CB 7 KEGG hsa00514 Other types of O-glycan biosynthesis 5/801 47/8144 0.4973 0.9995 0.9846 XXYLT1/GALNT18/ST6GAL1/MFNG/C1GALT1C1L 5 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 4/801 37/8144 0.5003 0.9995 0.9846 ATP1B1/ATP1A1/ATP1B2/INSR 4 KEGG hsa05143 African trypanosomiasis 4/801 37/8144 0.5003 0.9995 0.9846 TNF/IDO1/IFNG/FASLG 4 KEGG hsa04015 Rap1 signaling pathway 21/801 210/8144 0.5025 0.9995 0.9846 TEK/CSF1R/RAPGEF4/FGFR2/LPAR5/FGF23/CDC42/RAPGEF5/LAT/ANGPT2/PLCG1/FGFR1/BRAF/NGFR/KIT/CDH1/PDGFRB/ADCY6/FGFR4/INSR/GNAO1 21 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 3/801 27/8144 0.5041 0.9995 0.9846 ELOVL1/ELOVL3/ELOVL4 3 KEGG hsa00830 Retinol metabolism 7/801 68/8144 0.5088 0.9995 0.9846 HSD17B6/AOX1/ALDH1A2/CYP1A2/CYP2A7/CYP2S1/CYP2B6 7 KEGG hsa04664 Fc epsilon RI signaling pathway 7/801 68/8144 0.5088 0.9995 0.9846 TNF/FYN/INPP5D/GRB2/LAT/PLCG1/SOS2 7 KEGG hsa04935 Growth hormone synthesis, secretion and action 12/801 119/8144 0.509 0.9995 0.9846 MAP3K1/GHRH/GH2/SSTR2/GRB2/SOCS2/PLCG1/STAT3/CREBBP/SOS2/ADCY6/CACNA1C 12 KEGG hsa00120 Primary bile acid biosynthesis 2/801 17/8144 0.5091 0.9995 0.9846 CH25H/AKR1D1 2 KEGG hsa00910 Nitrogen metabolism 2/801 17/8144 0.5091 0.9995 0.9846 CA1/CA5A 2 KEGG hsa05171 Coronavirus disease - COVID-19 23/801 232/8144 0.5171 0.9995 0.9846 TNF/FGG/IFNA1/C3AR1/RPL21/C6/TLR4/RPL27A/IFNA13/IFNAR1/RPL31/RPL18/RPS26/SELP/RPL4/PLCG1/STAT3/TMPRSS2/MBL2/NRP1/MMP3/RPS11/OAS3 23 KEGG hsa05169 Epstein-Barr virus infection 20/801 202/8144 0.5229 0.9995 0.9846 CD3D/TNF/RUNX3/HLA-DRA/RBPJ/PSMD4/CD3G/IFNA1/BID/CASP3/IFNA13/IFNAR1/CCND2/CDK6/STAT3/PSMD13/BCL2/CD247/OAS3/CD58 20 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 7/801 69/8144 0.5247 0.9995 0.9846 GSTO2/EPHX1/NAT2/GSTT2B/MGST1/CYP1A2/CYP2A7 7 KEGG hsa04370 VEGF signaling pathway 6/801 59/8144 0.5295 0.9995 0.9846 SH2D2A/PPP3CC/CDC42/PLCG1/PPP3CB/SPHK1 6 KEGG hsa04145 Phagosome 15/801 152/8144 0.5352 0.9995 0.9846 HLA-DRA/CORO1A/ATP6V0D2/FCGR2B/COLEC11/SEC61G/TLR4/SFTPA2/FCAR/CLEC4M/CYBA/ATP6V0B/MBL2/DYNC1I2/TUBB8 15 KEGG hsa04728 Dopaminergic synapse 13/801 132/8144 0.5415 0.9995 0.9846 CAMK2G/KCNJ6/GNGT2/PPP3CC/PPP1CA/LRTOMT/PPP2R3A/PPP2R5C/CACNA1B/CACNA1C/GSK3A/PPP3CB/GNAO1 13 KEGG hsa00513 Various types of N-glycan biosynthesis 4/801 39/8144 0.543 0.9995 0.9846 MGAT4D/ALG3/ALG12/HEXA 4 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 19/801 194/8144 0.5441 0.9995 0.9846 PIK3CG/IFNA1/BID/CASP3/GNGT2/PPP3CC/IFNA13/LEF1/RCAN1/IFNAR1/ANGPT2/CDK6/PLCG1/STAT3/CCR5/CREBBP/MAP1LC3C/TCF7/PPP3CB 19 KEGG hsa05163 Human cytomegalovirus infection 22/801 225/8144 0.5456 0.9995 0.9846 TNF/CCL3/IFNA1/IL10RA/BID/CASP3/GNGT2/PPP3CC/RPS6KB2/IFNA13/GNA12/GRB2/TSC1/CDK6/FASLG/STAT3/CCR5/SOS2/ADCY6/ARHGEF12/PPP3CB/GNAO1 22 KEGG hsa01240 Biosynthesis of cofactors 15/801 153/8144 0.5458 0.9995 0.9846 HSD17B6/PMM1/NMNAT3/IDO1/FLAD1/AKR1A1/PDXP/PNPO/MAT1A/MTHFD2L/AK8/EARS2/ALDH3A2/COASY/AK7 15 KEGG hsa04921 Oxytocin signaling pathway 15/801 154/8144 0.5564 0.9995 0.9846 PIK3CG/CAMK2G/KCNJ6/PPP3CC/PRKAG1/PPP1CA/RCAN1/RYR2/CACNA2D4/CACNA2D3/RYR1/ADCY6/CACNA1C/PPP3CB/GNAO1 15 KEGG hsa00531 Glycosaminoglycan degradation 2/801 19/8144 0.5706 0.9995 0.9846 GLB1/HEXA 2 KEGG hsa05223 Non-small cell lung cancer 7/801 72/8144 0.5713 0.9995 0.9846 ALK/GRB2/CDK6/PLCG1/STAT3/BRAF/SOS2 7 KEGG hsa04670 Leukocyte transendothelial migration 11/801 114/8144 0.5736 0.9995 0.9846 MYL12A/OCLN/RAPGEF4/TXK/CDC42/CYBA/PLCG1/CLDN19/CLDN1/MMP2/CLDN17 11 KEGG hsa00053 Ascorbate and aldarate metabolism 3/801 30/8144 0.5773 0.9995 0.9846 AKR1A1/ALDH7A1/ALDH3A2 3 KEGG hsa01523 Antifolate resistance 3/801 30/8144 0.5773 0.9995 0.9846 TNF/TYMS/ABCG2 3 KEGG hsa04216 Ferroptosis 4/801 41/8144 0.5837 0.9995 0.9846 ACSL3/SLC39A8/MAP1LC3C/PCBP2 4 KEGG hsa04657 IL-17 signaling pathway 9/801 94/8144 0.5854 0.9995 0.9846 TNF/FOSL1/CASP3/IL17A/IFNG/ANAPC5/MUC5AC/MAPK6/MMP3 9 KEGG hsa04726 Serotonergic synapse 11/801 115/8144 0.5856 0.9995 0.9846 HTR3A/CASP3/KCNJ6/GNGT2/TRPC1/SLC6A4/HTR1B/BRAF/CACNA1B/CACNA1C/GNAO1 11 KEGG hsa01524 Platinum drug resistance 7/801 73/8144 0.5864 0.9995 0.9846 GSTO2/BID/CASP3/GSTT2B/MGST1/FASLG/BCL2 7 KEGG hsa04210 Apoptosis 13/801 136/8144 0.5865 0.9995 0.9846 TNF/TRAF1/PARP1/TNFRSF10B/BID/CASP3/CASP2/DDIT3/FASLG/GZMB/DIABLO/BCL2/SPTAN1 13 KEGG hsa05224 Breast cancer 14/801 147/8144 0.5923 0.9995 0.9846 WNT8A/FGF23/WNT6/RPS6KB2/LEF1/GRB2/CSNK1A1L/CDK6/FGFR1/BRAF/AXIN1/KIT/TCF7/SOS2 14 KEGG hsa05217 Basal cell carcinoma 6/801 63/8144 0.5957 0.9995 0.9846 WNT8A/WNT6/LEF1/SUFU/AXIN1/TCF7 6 KEGG hsa05135 Yersinia infection 13/801 137/8144 0.5974 0.9995 0.9846 TNF/WIPF2/TLR4/ACTR3C/WASF2/CDC42/SKAP2/WIPF1/LAT/PLCG1/ARHGEF7/CD4/ARHGEF12 13 KEGG hsa00100 Steroid biosynthesis 2/801 20/8144 0.5991 0.9995 0.9846 TM7SF2/CYP2R1 2 KEGG hsa00670 One carbon pool by folate 2/801 20/8144 0.5991 0.9995 0.9846 MTHFD2L/TYMS 2 KEGG hsa00410 beta-Alanine metabolism 3/801 31/8144 0.6001 0.9995 0.9846 ALDH7A1/ALDH3A2/ALDH3A1 3 KEGG hsa04530 Tight junction 16/801 169/8144 0.6032 0.9995 0.9846 MYL12A/OCLN/CD1E/CD1A/CD1C/MAP3K1/MARVELD2/PRKAG1/ACTR3C/CDC42/PRKCE/ARHGEF2/CLDN19/CLDN1/SLC9A3R1/CLDN17 16 KEGG hsa01232 Nucleotide metabolism 8/801 85/8144 0.6064 0.9995 0.9846 PNP/ENPP3/NT5M/TYMS/AK8/NT5C/UPP1/AK7 8 KEGG hsa04012 ErbB signaling pathway 8/801 85/8144 0.6064 0.9995 0.9846 CAMK2G/RPS6KB2/GRB2/PAK1/CBLB/PLCG1/BRAF/SOS2 8 KEGG hsa04610 Complement and coagulation cascades 8/801 85/8144 0.6064 0.9995 0.9846 FGG/C3AR1/C6/A2M/CFHR1/CR1/MBL2/PROCR 8 KEGG hsa04918 Thyroid hormone synthesis 7/801 75/8144 0.6157 0.9995 0.9846 IYD/TTF2/ATP1B1/ATP1A1/ATP1B2/ADCY6/TG 7 KEGG hsa05214 Glioma 7/801 75/8144 0.6157 0.9995 0.9846 CAMK2G/GRB2/CDK6/PLCG1/BRAF/SOS2/PDGFRB 7 KEGG hsa04371 Apelin signaling pathway 13/801 139/8144 0.6189 0.9995 0.9846 MEF2D/PIK3CG/GNGT2/RPS6KB2/PRKAG1/RYR2/PRKCE/SLC9A1/MAP1LC3C/RYR1/CDH1/ADCY6/SPHK1 13 KEGG hsa05418 Fluid shear stress and atherosclerosis 13/801 139/8144 0.6189 0.9995 0.9846 TNF/GSTO2/SDC1/GSTT2B/IFNG/MGST1/IL1A/CYBA/ARHGEF2/MIR10A/BCL2/MMP2/ACVR2A 13 KEGG hsa00071 Fatty acid degradation 4/801 43/8144 0.6223 0.9995 0.9846 ALDH7A1/ACSL3/ACAA2/ALDH3A2 4 KEGG hsa04975 Fat digestion and absorption 4/801 43/8144 0.6223 0.9995 0.9846 FABP2/PLA2G2D/APOB/PNLIPRP1 4 KEGG hsa04931 Insulin resistance 10/801 108/8144 0.6282 0.9995 0.9846 TNF/PTPN1/RPS6KB2/PRKAG1/PPP1CA/PRKCE/STAT3/SLC27A3/NR1H3/INSR 10 KEGG hsa05212 Pancreatic cancer 7/801 76/8144 0.6299 0.9995 0.9846 TGFB2/RPS6KB2/CDC42/CDK6/STAT3/BRAF/TGFBR2 7 KEGG hsa05220 Chronic myeloid leukemia 7/801 76/8144 0.6299 0.9995 0.9846 CTBP2/TGFB2/GRB2/CDK6/BRAF/SOS2/TGFBR2 7 KEGG hsa05202 Transcriptional misregulation in cancer 18/801 193/8144 0.6312 0.9995 0.9846 CSF1R/TRAF1/KMT2A/DDIT3/SPI1/KLF3/CCND2/GZMB/TMPRSS2/ARNT2/NGFR/MMP3/CCNT2/ZEB1/ITGB7/TGFBR2/HOXA9/CCNT1 18 KEGG hsa04722 Neurotrophin signaling pathway 11/801 119/8144 0.6322 0.9995 0.9846 CAMK2G/MAP3K1/GRB2/CDC42/FASLG/PLCG1/BRAF/NGFR/BCL2/ZNF274/SOS2 11 KEGG hsa04962 Vasopressin-regulated water reabsorption 4/801 44/8144 0.6407 0.9995 0.9846 DCTN5/DYNLL2/DYNC1I2/ADCY6 4 KEGG hsa00051 Fructose and mannose metabolism 3/801 33/8144 0.6433 0.9995 0.9846 PFKFB4/PMM1/AKR1B1 3 KEGG hsa04152 AMPK signaling pathway 11/801 120/8144 0.6434 0.9995 0.9846 PFKFB4/STRADA/RPS6KB2/PRKAG1/TSC1/PPP2R3A/PPP2R5C/ADIPOQ/ADIPOR1/INSR/TBC1D1 11 KEGG hsa00900 Terpenoid backbone biosynthesis 2/801 22/8144 0.6518 0.9995 0.9846 DHDDS/PCYOX1 2 KEGG hsa04919 Thyroid hormone signaling pathway 11/801 121/8144 0.6544 0.9995 0.9846 HDAC3/RCAN1/MED24/ATP1B1/PLCZ1/ATP1A1/PLN/ATP1B2/SLC9A1/PLCG1/CREBBP 11 KEGG hsa00040 Pentose and glucuronate interconversions 3/801 34/8144 0.6636 0.9995 0.9846 AKR1A1/DHDH/AKR1B1 3 KEGG hsa01212 Fatty acid metabolism 5/801 57/8144 0.6723 0.9995 0.9846 ELOVL1/ACSL3/ELOVL3/ACAA2/ELOVL4 5 KEGG hsa04916 Melanogenesis 9/801 101/8144 0.6725 0.9995 0.9846 WNT8A/CAMK2G/WNT6/LEF1/CREBBP/KIT/TCF7/ADCY6/GNAO1 9 KEGG hsa04934 Cushing syndrome 14/801 155/8144 0.6726 0.9995 0.9846 WNT8A/CAMK2G/KMT2A/WNT6/ORAI1/ARNT/CRHR2/LEF1/CDK6/BRAF/AXIN1/TCF7/ADCY6/CACNA1C 14 KEGG hsa04270 Vascular smooth muscle contraction 12/801 134/8144 0.6778 0.9995 0.9846 PLA2G2D/KCNMB1/EDN3/PPP1CA/GNA12/KCNU1/PRKCE/BRAF/CALCA/ADCY6/ARHGEF12/CACNA1C 12 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 1/801 11/8144 0.6801 0.9995 0.9846 TAT 1 KEGG hsa04150 mTOR signaling pathway 14/801 156/8144 0.682 0.9995 0.9846 TNF/LAMTOR1/WNT8A/SEH1L/STRADA/CLIP1/WNT6/RPS6KB2/GRB2/TSC1/DEPDC5/BRAF/SOS2/INSR 14 KEGG hsa04920 Adipocytokine signaling pathway 6/801 69/8144 0.6848 0.9995 0.9846 TNF/PRKAG1/ACSL3/STAT3/ADIPOQ/ADIPOR1 6 KEGG hsa04924 Renin secretion 6/801 69/8144 0.6848 0.9995 0.9846 PPP3CC/ORAI1/EDN3/ADCY6/CACNA1C/PPP3CB 6 KEGG hsa04725 Cholinergic synapse 10/801 113/8144 0.685 0.9995 0.9846 PIK3CG/CAMK2G/FYN/KCNJ6/GNGT2/BCL2/CACNA1B/ADCY6/CACNA1C/GNAO1 10 KEGG hsa00240 Pyrimidine metabolism 5/801 58/8144 0.6873 0.9995 0.9846 ENPP3/NT5M/TYMS/NT5C/UPP1 5 KEGG hsa00620 Pyruvate metabolism 4/801 47/8144 0.6923 0.9995 0.9846 AKR1A1/ALDH7A1/ME2/ALDH3A2 4 KEGG hsa03420 Nucleotide excision repair 4/801 47/8144 0.6923 0.9995 0.9846 POLE4/GTF2H3/ERCC6/CCNH 4 KEGG hsa05166 Human T-cell leukemia virus 1 infection 20/801 222/8144 0.6958 0.9995 0.9846 CD3D/TNF/HLA-DRA/TNFRSF13C/CD3G/FOSL1/TBPL2/MAP3K1/TGFB2/SPI1/PPP3CC/MMP7/CCND2/CD4/ANAPC5/CREBBP/NRP1/ADCY6/TGFBR2/PPP3CB 20 KEGG hsa04917 Prolactin signaling pathway 6/801 70/8144 0.6983 0.9995 0.9846 GRB2/SOCS2/CCND2/PRLR/STAT3/SOS2 6 KEGG hsa04977 Vitamin digestion and absorption 2/801 24/8144 0.6989 0.9995 0.9846 APOB/TCN2 2 KEGG hsa04510 Focal adhesion 18/801 201/8144 0.6992 0.9995 0.9846 MYL12A/FYN/ITGA11/PPP1CA/LAMB1/PARVA/GRB2/PAK1/CDC42/LAMA3/COL1A1/CCND2/ILK/BRAF/BCL2/SOS2/PDGFRB/ITGB7 18 KEGG hsa05207 Chemical carcinogenesis - receptor activation 19/801 212/8144 0.7013 0.9995 0.9846 GSTO2/MIRLET7B/EPHX1/PAQR5/RPS6KB2/ARNT/MIRLET7A3/GRB2/GSTT2B/MGST1/MIRLET7F1/STAT3/CYP1A2/BCL2/CACNA1B/SOS2/ADCY6/CYP2B6/CACNA1C 19 KEGG hsa04625 C-type lectin receptor signaling pathway 9/801 104/8144 0.7063 0.9995 0.9846 TNF/IL23A/CCL22/PPP3CC/PAK1/CBLB/CLEC4M/ARHGEF12/PPP3CB 9 KEGG hsa04912 GnRH signaling pathway 8/801 93/8144 0.7071 0.9995 0.9846 CAMK2G/MAP3K1/GRB2/CDC42/SOS2/ADCY6/CACNA1C/MMP2 8 KEGG hsa01250 Biosynthesis of nucleotide sugars 3/801 37/8144 0.7195 0.9995 0.9846 PMM1/UAP1/GNE 3 KEGG hsa04360 Axon guidance 16/801 182/8144 0.7202 0.9995 0.9846 MYL12A/CAMK2G/FYN/TRPC1/PPP3CC/SRGAP3/EPHB1/PAK1/CDC42/ILK/PLCG1/NRP1/PLXNA2/ARHGEF12/RND1/PPP3CB 16 KEGG hsa05218 Melanoma 6/801 72/8144 0.7242 0.9995 0.9846 FGF23/CDK6/FGFR1/BRAF/CDH1/PDGFRB 6 KEGG hsa00230 Purine metabolism 11/801 128/8144 0.726 0.9995 0.9846 PNP/ENPP3/PDE6D/PDE6H/PFAS/NT5M/PDE4B/AK8/NT5C/ADCY6/AK7 11 KEGG hsa04926 Relaxin signaling pathway 11/801 129/8144 0.7354 0.9995 0.9846 GNGT2/RXFP3/GRB2/COL1A1/INSL5/RXFP1/SOS2/ADCY6/MMP2/TGFBR2/GNAO1 11 KEGG hsa05132 Salmonella infection 22/801 249/8144 0.7357 0.9995 0.9846 MYL12A/TNF/RHOJ/PIK3CG/TNFRSF10B/DCTN5/CASP3/TLR4/ACTR3C/LEF1/DYNLL2/PAK1/CDC42/WASF3/DYNC1I2/CYTH1/BCL2/TUBB8/BRK1/TCF7/PTPRC/SNX9 22 KEGG hsa00510 N-Glycan biosynthesis 4/801 50/8144 0.7384 0.9995 0.9846 MGAT4D/ALG3/ST6GAL1/ALG12 4 KEGG hsa04979 Cholesterol metabolism 4/801 50/8144 0.7384 0.9995 0.9846 APOH/APOB/APOC2/LDLRAP1 4 KEGG hsa05110 Vibrio cholerae infection 4/801 50/8144 0.7384 0.9995 0.9846 ATP6V0D2/SEC61G/ATP6V0B/PLCG1 4 KEGG hsa03450 Non-homologous end-joining 1/801 13/8144 0.74 0.9995 0.9846 NHEJ1 1 KEGG hsa00790 Folate biosynthesis 2/801 26/8144 0.7406 0.9995 0.9846 MOCOS/AKR1B1 2 KEGG hsa04213 Longevity regulating pathway - multiple species 5/801 62/8144 0.7429 0.9995 0.9846 HSPA1B/RPS6KB2/PRKAG1/ADCY6/INSR 5 KEGG hsa04071 Sphingolipid signaling pathway 10/801 119/8144 0.7458 0.9995 0.9846 TNF/BID/FYN/SGPL1/GNA12/PPP2R3A/PPP2R5C/PRKCE/BCL2/SPHK1 10 KEGG hsa03015 mRNA surveillance pathway 8/801 97/8144 0.7506 0.9995 0.9846 CPSF4L/WDR33/MSI2/FIP1L1/PPP1CA/PPP2R3A/PPP2R5C/WDR82 8 KEGG hsa04713 Circadian entrainment 8/801 97/8144 0.7506 0.9995 0.9846 CAMK2G/KCNJ6/GNGT2/RYR2/RYR1/ADCY6/CACNA1C/GNAO1 8 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 2/801 27/8144 0.7595 0.9995 0.9846 GCNT2/B3GALT1 2 KEGG hsa01522 Endocrine resistance 8/801 98/8144 0.7607 0.9995 0.9846 RPS6KB2/GRB2/BRAF/BCL2/BIK/SOS2/ADCY6/MMP2 8 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 12/801 143/8144 0.7609 0.9995 0.9846 WNT8A/FGFR2/WNT6/GRB2/STAT3/LEFTY2/FGFR1/AXIN1/TCF7/SETDB1/FGFR4/ACVR2A 12 KEGG hsa05133 Pertussis 6/801 76/8144 0.7712 0.9995 0.9846 TNF/CASP3/IL23A/TLR4/SFTPA2/IL1A 6 KEGG hsa04512 ECM-receptor interaction 7/801 88/8144 0.7754 0.9995 0.9846 ITGA11/DSPP/SDC1/LAMB1/LAMA3/COL1A1/ITGB7 7 KEGG hsa04540 Gap junction 7/801 88/8144 0.7754 0.9995 0.9846 CSNK1D/GJD2/GRB2/TUBB8/SOS2/PDGFRB/ADCY6 7 KEGG hsa05100 Bacterial invasion of epithelial cells 6/801 77/8144 0.7819 0.9995 0.9846 ACTR3C/WASF2/CDC42/CLTB/ILK/CDH1 6 KEGG hsa05219 Bladder cancer 3/801 41/8144 0.7824 0.9995 0.9846 BRAF/CDH1/MMP2 3 KEGG hsa04211 Longevity regulating pathway 7/801 89/8144 0.7853 0.9995 0.9846 RPS6KB2/PRKAG1/TSC1/ADIPOQ/ADIPOR1/ADCY6/INSR 7 KEGG hsa04727 GABAergic synapse 7/801 89/8144 0.7853 0.9995 0.9846 KCNJ6/GNGT2/SLC38A2/CACNA1B/ADCY6/CACNA1C/GNAO1 7 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/801 15/8144 0.7887 0.9995 0.9846 HEXA 1 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 5/801 66/8144 0.7908 0.9995 0.9846 NARS2/AARS2/PSTK/EARS2/IARS2 5 KEGG hsa05131 Shigellosis 21/801 247/8144 0.7923 0.9995 0.9846 MYL12A/TNF/FNBP1/TLR4/RPS6KB2/ACTR3C/WASF2/CDC42/PLCZ1/UBE2D3/PRKCE/ARHGEF2/ILK/PLCG1/UBE2N/CYTH1/BCL2/MAP1LC3C/WIPI1/GLMN/GSK3A 21 KEGG hsa00591 Linoleic acid metabolism 2/801 29/8144 0.7938 0.9995 0.9846 PLA2G2D/CYP1A2 2 KEGG hsa00010 Glycolysis / Gluconeogenesis 5/801 67/8144 0.8017 0.9995 0.9846 AKR1A1/ALDH7A1/BPGM/ALDH3A2/ALDH3A1 5 KEGG hsa05032 Morphine addiction 7/801 91/8144 0.8042 0.9995 0.9846 OPRM1/KCNJ6/GNGT2/PDE4B/CACNA1B/ADCY6/GNAO1 7 KEGG hsa00860 Porphyrin metabolism 3/801 43/8144 0.8092 0.9995 0.9846 BLVRA/HEPHL1/EARS2 3 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 2/801 30/8144 0.8092 0.9995 0.9846 GCSH/CS 2 KEGG hsa00430 Taurine and hypotaurine metabolism 1/801 16/8144 0.8095 0.9995 0.9846 CDO1 1 KEGG hsa04915 Estrogen signaling pathway 11/801 138/8144 0.8102 0.9995 0.9846 OPRM1/KCNJ6/HSPA1B/GRB2/BCL2/TFF1/SOS2/ADCY6/MMP2/KRT31/GNAO1 11 KEGG hsa00983 Drug metabolism - other enzymes 6/801 80/8144 0.8119 0.9995 0.9846 GSTO2/NAT2/GSTT2B/MGST1/CYP2A7/UPP1 6 KEGG hsa04620 Toll-like receptor signaling pathway 8/801 104/8144 0.8153 0.9995 0.9846 TNF/CCL3/IFNA1/TLR4/IFNA13/IFNAR1/LBP/CD80 8 KEGG hsa04970 Salivary secretion 7/801 93/8144 0.8218 0.9995 0.9846 ATP2B1/LYZL1/ATP1B1/ATP1A1/ATP1B2/SLC9A1/ADCY6 7 KEGG hsa05031 Amphetamine addiction 5/801 69/8144 0.822 0.9995 0.9846 CAMK2G/PPP3CC/PPP1CA/CACNA1C/PPP3CB 5 KEGG hsa00052 Galactose metabolism 2/801 31/8144 0.8236 0.9995 0.9846 GLB1/AKR1B1 2 KEGG hsa04710 Circadian rhythm 2/801 31/8144 0.8236 0.9995 0.9846 CSNK1D/PRKAG1 2 KEGG hsa05310 Asthma 2/801 31/8144 0.8236 0.9995 0.9846 TNF/HLA-DRA 2 KEGG hsa04622 RIG-I-like receptor signaling pathway 5/801 70/8144 0.8315 0.9995 0.9846 TNF/IFNA1/MAP3K1/IFNA13/PIN1 5 KEGG hsa05230 Central carbon metabolism in cancer 5/801 70/8144 0.8315 0.9995 0.9846 FGFR2/FGFR1/KIT/SLC1A5/PDGFRB 5 KEGG hsa00480 Glutathione metabolism 4/801 58/8144 0.8356 0.9995 0.9846 GSTO2/ANPEP/GSTT2B/MGST1 4 KEGG hsa03050 Proteasome 3/801 46/8144 0.8441 0.9995 0.9846 PSMD4/IFNG/PSMD13 3 KEGG hsa00061 Fatty acid biosynthesis 1/801 18/8144 0.8452 0.9995 0.9846 ACSL3 1 KEGG hsa04330 Notch signaling pathway 4/801 59/8144 0.8453 0.9995 0.9846 RBPJ/CTBP2/MFNG/CREBBP 4 KEGG hsa03013 Nucleocytoplasmic transport 8/801 108/8144 0.8461 0.9995 0.9846 SEH1L/XPO6/NUP210/NUP93/EEF1A1/POM121/NUP210L/SNUPN 8 KEGG hsa04973 Carbohydrate digestion and absorption 3/801 47/8144 0.8545 0.9995 0.9846 ATP1B1/ATP1A1/ATP1B2 3 KEGG hsa04730 Long-term depression 4/801 60/8144 0.8545 0.9995 0.9846 GNA12/BRAF/RYR1/GNAO1 4 KEGG hsa01210 2-Oxocarboxylic acid metabolism 1/801 19/8144 0.8605 0.9995 0.9846 CS 1 KEGG hsa05203 Viral carcinogenesis 16/801 204/8144 0.8631 0.9995 0.9846 ATP6V0D2/RBPJ/TRAF1/HDAC3/TBPL2/CASP3/YWHAZ/GTF2H3/GRB2/CDC42/CCND2/YWHAG/CDK6/STAT3/CCR5/CREBBP 16 KEGG hsa05020 Prion disease 22/801 273/8144 0.8673 0.9995 0.9846 TNF/PSMD4/NDUFS2/CASP3/FYN/NCAM1/HSPA1B/DDIT3/C6/PPP3CC/COX7A2/RYR2/STIP1/IL1A/CYBA/PSMD13/CACNA1B/TUBB8/RYR1/CACNA1C/NDUFB7/PPP3CB 22 KEGG hsa04611 Platelet activation 9/801 124/8144 0.8724 0.9995 0.9846 MYL12A/FGG/PIK3CG/FYN/ORAI1/PPP1CA/COL1A1/ADCY6/ARHGEF12 9 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/801 20/8144 0.8742 0.9995 0.9846 XYLT2 1 KEGG hsa04623 Cytosolic DNA-sensing pathway 4/801 63/8144 0.8795 0.9995 0.9846 IFNA1/IFNA13/POLR2F/POLR3A 4 KEGG hsa00500 Starch and sucrose metabolism 2/801 36/8144 0.882 0.9995 0.9846 ENPP3/GBE1 2 KEGG hsa03030 DNA replication 2/801 36/8144 0.882 0.9995 0.9846 POLE4/MCM2 2 KEGG hsa00330 Arginine and proline metabolism 3/801 51/8144 0.8901 0.9995 0.9846 ALDH18A1/ALDH7A1/ALDH3A2 3 KEGG hsa03018 RNA degradation 5/801 79/8144 0.8997 0.9995 0.9846 PATL1/DDX6/DCP1B/HSPA9/EXOSC7 5 KEGG hsa05222 Small cell lung cancer 6/801 92/8144 0.9006 0.9995 0.9846 TRAF1/CASP3/LAMB1/LAMA3/CDK6/BCL2 6 KEGG hsa00515 Mannose type O-glycan biosynthesis 1/801 23/8144 0.9079 0.9995 0.9846 POMGNT2 1 KEGG hsa03060 Protein export 1/801 23/8144 0.9079 0.9995 0.9846 SEC61G 1 KEGG hsa04218 Cellular senescence 11/801 156/8144 0.911 0.9995 0.9846 TGFB2/PPP3CC/PPP1CA/TSC1/TRPM7/IL1A/CCND2/CDK6/E2F5/TGFBR2/PPP3CB 11 KEGG hsa04922 Glucagon signaling pathway 7/801 107/8144 0.9125 0.9995 0.9846 PPP4R3B/CAMK2G/PPP3CC/PRKAG1/GCG/CREBBP/PPP3CB 7 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/801 24/8144 0.917 0.9995 0.9846 XYLT2 1 KEGG hsa03010 Ribosome 11/801 158/8144 0.9188 0.9995 0.9846 RPL21/RPL27A/RPL31/RPL18/RPS26/RPL4/MRPL22/MRPL16/MRPS6/RPS11/MRPS15 11 KEGG hsa03008 Ribosome biogenesis in eukaryotes 7/801 109/8144 0.9215 0.9995 0.9846 RIOK2/RBM28/TCOF1/NOP58/NAT10/LSG1/NVL 7 KEGG hsa04923 Regulation of lipolysis in adipocytes 3/801 56/8144 0.9235 0.9995 0.9846 FABP4/ADCY6/INSR 3 KEGG hsa00592 alpha-Linolenic acid metabolism 1/801 25/8144 0.9252 0.9995 0.9846 PLA2G2D 1 KEGG hsa04714 Thermogenesis 17/801 232/8144 0.9261 0.9995 0.9846 SMARCC2/NDUFS2/RPS6KB2/COX7A2/PRKAG1/GRB2/TSC1/GCG/DPF3/ACSL3/FGFR1/SMARCB1/SOS2/ADCY6/NDUFB7/SMARCC1/SMARCD2 17 KEGG hsa05168 Herpes simplex virus 1 infection 40/801 495/8144 0.9268 0.9995 0.9846 TNF/HLA-DRA/ZNF354C/IFNA1/ZNF878/POU2F3/ZNF418/BID/CASP3/ZNF431/ZNF596/EIF2B1/ZNF714/ZNF471/SRSF8/ZNF506/ZNF382/IFNA13/ZNF140/PPP1CA/ZNF544/ZNF98/IFNAR1/ZNF136/TSC1/ZNF610/IFNG/ZNF30/ZNF846/ZNF273/FASLG/ZNF334/ZNF417/BCL2/ZNF583/ZNF443/ZNF154/ZNF737/OAS3/ZNF430 40 KEGG hsa04723 Retrograde endocannabinoid signaling 10/801 148/8144 0.927 0.9995 0.9846 NDUFS2/DAGLB/KCNJ6/GNGT2/ABHD6/CACNA1B/ADCY6/CACNA1C/NDUFB7/GNAO1 10 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/801 26/8144 0.9325 0.9995 0.9846 PIGW 1 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 16/801 223/8144 0.9341 0.9995 0.9846 GSTO2/PTPN1/NDUFS2/EPHX1/AKR1A1/COX7A2/ARNT/GRB2/GSTT2B/SLC26A9/MGST1/CYBA/CYP1A2/BRAF/SOS2/NDUFB7 16 KEGG hsa04966 Collecting duct acid secretion 1/801 27/8144 0.9392 0.9995 0.9846 ATP6V0D2 1 KEGG hsa05415 Diabetic cardiomyopathy 14/801 203/8144 0.9446 0.9995 0.9846 PARP1/CAMK2G/NDUFS2/TGFB2/COX7A2/PPP1CA/RYR2/COL1A1/CYBA/PLN/NDUFB7/MMP2/TGFBR2/INSR 14 KEGG hsa00650 Butanoate metabolism 1/801 28/8144 0.9452 0.9995 0.9846 OXCT1 1 KEGG hsa00590 Arachidonic acid metabolism 3/801 61/8144 0.9474 0.9995 0.9846 PLA2G2D/CYP4F3/CYP2B6 3 KEGG hsa05017 Spinocerebellar ataxia 9/801 143/8144 0.9502 0.9995 0.9846 RBPJ/PSMD4/TBPL2/BEAN1/NFYA/PSMD13/RYR1/XBP1/WIPI1 9 KEGG hsa04744 Phototransduction 1/801 29/8144 0.9506 0.9995 0.9846 GUCA1B 1 KEGG hsa00020 Citrate cycle (TCA cycle) 1/801 30/8144 0.9555 0.9995 0.9846 CS 1 KEGG hsa04929 GnRH secretion 3/801 64/8144 0.9582 0.9995 0.9846 KCNJ6/TRPC1/CACNA1C 3 KEGG hsa04927 Cortisol synthesis and secretion 3/801 65/8144 0.9613 0.9995 0.9846 ORAI1/ADCY6/CACNA1C 3 KEGG hsa04136 Autophagy - other 1/801 32/8144 0.9638 0.9995 0.9846 WIPI1 1 KEGG hsa04913 Ovarian steroidogenesis 2/801 51/8144 0.967 0.9995 0.9846 ADCY6/INSR 2 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 5/801 98/8144 0.9702 0.9995 0.9846 CAMK2G/PPP1CA/PRKCE/PLCG1/ADCY6 5 KEGG hsa03460 Fanconi anemia pathway 2/801 54/8144 0.9746 0.9995 0.9846 POLN/FANCL 2 KEGG hsa04621 NOD-like receptor signaling pathway 11/801 184/8144 0.9778 0.9995 0.9846 TNF/NLRP1/IFNA1/TLR4/IFNA13/IFNAR1/TRPM7/CYBA/BCL2/MAP1LC3C/OAS3 11 KEGG hsa04141 Protein processing in endoplasmic reticulum 10/801 171/8144 0.9779 0.9995 0.9846 SEC61G/HSPA1B/DDIT3/ERO1B/UBE4B/UBE2D3/BCL2/NPLOC4/XBP1/SEL1L2 10 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 35/801 476/8144 0.978 0.9995 0.9846 TNF/WNT8A/PSMD4/CAMK2G/NDUFS2/DCTN5/BID/CASP3/DDIT3/PPP3CC/WNT6/COX7A2/RYR2/MAPT/DNAI1/IL1A/CSNK1A1L/TOMM40L/FASLG/SNCAIP/PLCG1/PSMD13/BRAF/BCL2/AXIN1/MAP1LC3C/CACNA1B/TUBB8/RYR1/XBP1/WIPI1/CACNA1C/NDUFB7/UBE2L6/PPP3CB 35 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 1/801 37/8144 0.9785 0.9995 0.9846 IL4I1 1 KEGG hsa03040 Spliceosome 8/801 147/8144 0.9812 0.9995 0.9846 SF3B4/PRPF38B/HSPA1B/SRSF8/SNRPG/TRA2B/SF3A1/U2AF2 8 KEGG hsa01230 Biosynthesis of amino acids 3/801 75/8144 0.9825 0.9995 0.9846 ALDH18A1/MAT1A/CS 3 KEGG hsa05014 Amyotrophic lateral sclerosis 25/801 364/8144 0.9829 0.9995 0.9846 TNF/SEH1L/PSMD4/NDUFS2/DCTN5/BID/CASP3/DDIT3/PPP3CC/COX7A2/NUP210/NUP93/SLC1A2/DNAI1/POM121/TOMM40L/PSMD13/NUP210L/BCL2/MAP1LC3C/TUBB8/XBP1/WIPI1/NDUFB7/PPP3CB 25 KEGG hsa05033 Nicotine addiction 1/801 40/8144 0.9843 0.9995 0.9846 CACNA1B 1 KEGG hsa03440 Homologous recombination 1/801 41/8144 0.9858 0.9995 0.9846 RBBP8 1 KEGG hsa05010 Alzheimer disease 26/801 384/8144 0.9877 0.9995 0.9846 TNF/WNT8A/PSMD4/NDUFS2/BID/CASP3/DDIT3/PPP3CC/WNT6/COX7A2/MAPT/APBB1/IL1A/CSNK1A1L/SLC39A12/SLC39A8/PSMD13/BRAF/AXIN1/TUBB8/XBP1/WIPI1/CACNA1C/NDUFB7/INSR/PPP3CB 26 KEGG hsa04140 Autophagy - animal 7/801 141/8144 0.9886 0.9995 0.9846 SH3GLB1/RPS6KB2/TSC1/MTMR14/BCL2/MAP1LC3C/WIPI1 7 KEGG hsa04146 Peroxisome 3/801 82/8144 0.9901 0.9995 0.9846 ACSL3/PHYH/PEX5L 3 KEGG hsa05012 Parkinson disease 16/801 266/8144 0.9909 0.9995 0.9846 PSMD4/CAMK2G/NDUFS2/CASP3/DDIT3/COX7A2/MAPT/SLC39A12/SLC39A8/SNCAIP/PLCG1/PSMD13/TUBB8/XBP1/NDUFB7/UBE2L6 16 KEGG hsa04914 Progesterone-mediated oocyte maturation 4/801 102/8144 0.9926 0.9995 0.9846 CPEB4/ANAPC5/BRAF/ADCY6 4 KEGG hsa05322 Systemic lupus erythematosus 6/801 136/8144 0.9941 0.9995 0.9846 TNF/HLA-DRA/CD28/C6/IFNG/CD80 6 KEGG hsa04137 Mitophagy - animal 2/801 72/8144 0.995 0.9995 0.9846 FIS1/MAP1LC3C 2 KEGG hsa05016 Huntington disease 18/801 306/8144 0.9956 0.9995 0.9846 KCNJ10/PSMD4/NDUFS2/TBPL2/DCTN5/CASP3/COX7A2/SLC1A2/POLR2F/CLTB/DNAI1/PSMD13/CREBBP/CACNA1B/TUBB8/WIPI1/NDUFB7/AP2A2 18 KEGG hsa04668 TNF signaling pathway 4/801 112/8144 0.9966 0.9995 0.9846 TNF/TRAF1/CASP3/MMP3 4 KEGG hsa00190 Oxidative phosphorylation 5/801 134/8144 0.9978 0.9995 0.9846 ATP6V0D2/NDUFS2/COX7A2/ATP6V0B/NDUFB7 5 KEGG hsa04613 Neutrophil extracellular trap formation 8/801 190/8144 0.9989 0.9995 0.9846 FGG/HDAC3/TLR4/SELP/CR1/CYBA/FPR3/PLCG1 8 KEGG hsa01200 Carbon metabolism 3/801 115/8144 0.9994 0.9995 0.9846 GCSH/CS/ME2 3 KEGG hsa05034 Alcoholism 7/801 187/8144 0.9995 0.9995 0.9846 HDAC3/GNGT2/PPP1CA/GRB2/BRAF/SOS2/GNAO1 7