ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04740	Olfactory transduction	337/5183	440/8144	1.467e-09	4.901e-07	3.692e-07	OR10T2/OR5A2/OR2H2/OR56B4/OR13J1/OR2M3/OR2A4/ARRB2/OR51D1/OR51B6/CALML3/OR52B2/OR10Z1/OR6Q1/OR10J5/OR10S1/OR8B2/OR2A7/OR51L1/OR56A1/OR51S1/OR8G5/OR2G3/OR10C1/CALML6/OR4D6/OR10J1/CALML4/OR10V1/OR2S2/OR52R1/OR1G1/OR9A4/OR56A4/OR2L3/OR2L2/OR5AU1/OR51G1/OR11A1/OR6N1/OR6K3/OR2T4/OR2H1/OR3A3/OR6C4/OR2W1/OR10A3/OR2J3/OR8U8/OR2T33/OR12D2/ANO2/OR10A2/OR51B4/OR4D11/CALML5/OR51E1/OR1C1/OR13D1/OR8S1/OR51F2/OR8D2/OR6V1/OR2AT4/OR5B12/OR9Q1/OR52W1/OR10G4/OR52N2/OR10H2/OR2T6/OR51V1/OR1A1/OR2T34/OR6Y1/OR2L8/OR1A2/OR6B1/OR10G7/OR2A2/OR2M2/OR5AN1/OR5H6/OR51A7/OR8B4/OR8D4/OR8H3/OR7G2/OR51E2/CAMK2A/OR10A6/OR10G3/OR7C2/OR5M10/OR1Q1/OR2A25/OR7A5/OR9Q2/OR10H1/OR2Y1/OR2D2/CNGA4/PRKACA/OR6B3/OR8B8/OR1E2/OR11L1/OR8J3/CAMK2B/OR2F2/OR10H5/OR6B2/OR6X1/OR10H3/OR51B2/OR8H1/OR9K2/OR5A1/SLC8A1/OR51F1/OR52N1/OR8B3/SLC24A4/OR7C1/OR56A3/OR51B5/OR10A4/CAMK2G/OR56A5/OR2A12/OR51G2/OR1L3/OR10W1/OR2J2/OR52E2/OR7D4/OR5T1/OR2T3/OR6K6/OR52E8/OR52E6/OR1I1/OR7A17/OR14J1/OR56B1/OR4F6/ARRB1/CNGB1/OR2AE1/OR52A1/OR52B6/OR8K5/OR51I2/OR2AK2/OR6C2/OR8I2/OR1B1/OR52L1/PDE1A/OR5H1/OR10H4/OR5D14/GUCY2D/OR51I1/OR2F1/OR12D3/OR1E1/OR1J1/OR4F5/OR6F1/OR6K2/OR5B3/PRKG2/OR10G9/OR7G1/OR2T12/OR52K1/OR10G2/OR2M7/OR5I1/OR5L2/OR1J4/OR5AK2/OR2T27/OR10P1/OR5AR1/ADCY3/OR4S1/OR7D2/OR5V1/OR8H2/OR13A1/OR5M8/OR5T3/OR6C74/OR2B6/OR5AP2/OR52E4/OR4X1/OR4C45/OR4D10/OR51T1/OR4C16/OR5P2/OR52I1/OR1N1/OR4M2/OR52M1/OR2B2/OR1M1/OR2M4/OR2G2/OR4B1/OR4C12/OR6C1/OR5L1/OR3A1/OR5W2/OR13C8/OR9G1/OR9G9/OR9G4/OR10X1/OR10G8/OR52I2/CALM1/PDE2A/OR4C3/OR5AS1/OR6M1/OR10A7/PDE1B/OR52K2/OR4D5/OR14I1/OR8D1/OR5K2/OR2W3/OR5B21/OR4E2/CALM2/OR2K2/OR10A5/OR10K2/OR10Q1/OR1D2/OR11H6/OR10AG1/OR7E24/OR11H4/OR5M1/GNG7/OR5R1/OR5K1/OR2T11/OR4F15/NCALD/OR2B3/OR2AG1/OR2D3/OR4P4/OR8J1/OR6C65/OR51M1/OR5D18/OR1S1/OR4D2/OR4M1/OR8K3/OR5M3/OR1J2/OR4N2/OR13H1/PRKG1/OR2T10/OR6T1/CNGA2/OR5AC2/PRKACB/OR4N5/OR7G3/OR2V2/OR5P3/OR1L6/OR1S2/OR5C1/OR51A2/OR13C3/OR6N2/SLC8A3/OR4K17/CNGA3/OR5B17/OR11H12/OR4C46/OR4D9/OR2T8/OR4A47/OR2A14/OR6C76/OR9I1/OR4K14/SLC8A2/OR4Q3/OR2T1/OR52A5/OR7A10/OR4A15/OR5H14/OR10R2/OR13G1/OR4X2/OR2Z1/OR6C3/OR1F1/OR52B4/GNB1/OR4L1/OR2C1/OR5D13/OR10AD1/OR6C70/OR6S1/CALM3/OR8U1/OR2AG2/OR6C75/OR4K2/OR5J2/OR9A2/OR2A1/OR2A42/OR14C36/OR6P1/OR2T29/OR4C6/OR4A16	337
KEGG	hsa04915	Estrogen signaling pathway	117/5183	138/8144	2.519e-08	4.206e-06	3.168e-06	KRT17/PIK3CD/SHC1/KRT14/KRT15/CALML3/CREB3L2/CALML6/HBEGF/ITPR1/CALML4/MAPK3/PRKCD/CREB3L4/CALML5/MMP9/HSPA8/RARA/GNAO1/GNAI3/ADCY4/KCNJ5/KRT38/GRB2/KRT39/PRKACA/FKBP4/KRT26/KRT13/KRT33A/ADCY5/KRT37/SP1/SHC2/KRT28/CREB5/TGFA/KRT9/KRT32/FKBP5/SHC4/AKT2/HSP90B1/KRT31/PIK3R2/KRT20/KRT16/KRT35/ESR1/TFF1/ITPR2/NRAS/ADCY3/MAPK1/KRT34/KRT40/MAP2K2/GRM1/PIK3R1/KRT33B/HRAS/RAF1/ATF2/ADCY6/KRT10/EGFR/HSP90AA1/CALM1/GABBR2/ADCY2/CREB3L3/KRAS/ADCY8/PLCB1/KRT19/KRT24/KRT23/CALM2/CREB3/GNAQ/KRT27/HSPA1A/MAP2K1/KCNJ3/HSPA2/BCL2/GNAI1/ADCY7/HSPA1L/PLCB4/CTSD/NCOA1/NCOA2/PGR/PLCB2/NCOA3/KRT18/POMC/PRKACB/PIK3R3/GNAS/PLCB3/GABBR1/MMP2/SOS2/EBAG9/PIK3CB/KRT25/HSP90AB1/FOS/KRT36/ADCY1/CALM3/KCNJ6/SOS1/ATF4/CREB1	117
KEGG	hsa04610	Complement and coagulation cascades	74/5183	85/8144	1.124e-06	0.0001251	9.426e-05	F2RL2/CLU/SERPINB2/CPB2/PLAUR/VSIG4/CD59/CFHR2/C4BPA/VTN/FGG/PROCR/C1QB/BDKRB1/C1QA/SERPING1/C3AR1/C5AR1/MASP1/CFD/F2/MBL2/FGA/F12/CR1/C9/ITGAM/C2/MASP2/KNG1/CFI/PLG/C8B/THBD/TFPI/C7/F10/C6/A2M/C4A/C4B/CFHR1/CFHR5/ITGB2/PLAU/C8A/F13B/CFB/CD46/KLKB1/C5/SERPIND1/C1QC/C4BPB/F11/FGB/CD55/SERPINE1/CR2/CFH/C1R/F5/C8G/SERPINA1/F3/BDKRB2/PROS1/C3/SERPINC1/F2RL3/PLAT/ITGAX/CR1L/VWF	74
KEGG	hsa05215	Prostate cancer	82/5183	97/8144	4.133e-06	0.0003451	0.00026	PIK3CD/TCF7/E2F1/CREB3L2/ERG/MAPK3/GSTP1/PDGFA/CREB3L4/LEF1/MMP9/NFKBIA/CDKN1A/ERBB2/GRB2/TMPRSS2/SPINT1/TP53/NFKB1/PTEN/INS/TCF7L1/ZEB1/CREB5/NKX3-1/TGFA/ETV5/AKT2/INSRR/HSP90B1/PIK3R2/KLK3/EP300/MMP3/PLAU/NRAS/MAPK1/IL1R2/MAP2K2/PDGFB/PIK3R1/HRAS/RAF1/EGFR/HSP90AA1/CREB3L3/KRAS/CASP9/MDM2/E2F3/PDGFC/PDGFD/FGFR1/CREB3/MAP2K1/EGF/BCL2/FOXO1/CDK2/IGF1R/FGFR2/RELA/CTNNB1/PIK3R3/TCF7L2/CREBBP/SOS2/E2F2/PIK3CB/PDGFRA/HSP90AB1/SRD5A2/CCNE1/MTOR/PDGFRB/BRAF/PLAT/CDKN1B/RB1/SOS1/ATF4/CREB1	82
KEGG	hsa04742	Taste transduction	73/5183	86/8144	1.034e-05	0.0006098	0.0004593	HTR3A/TAS2R38/GNB3/KCNK5/HTR1B/PKD2L1/HTR3B/PKD1L3/TAS2R16/TAS2R31/ADCY4/TAS2R39/HTR1F/GRM4/HTR1A/PRKACA/CHRM3/GABRA2/TRPM5/CACNA1A/SCNN1A/GNAT3/TAS2R5/GABRA4/SCN3A/TAS2R9/PDE1A/HTR1D/HTR3C/GABRA1/SCN9A/HTR1E/HTR3E/HCN4/GABRA6/GRM1/TAS1R3/ADCY6/GABBR2/GABRA5/PDE1B/TAS2R41/ADCY8/PLCB1/TAS2R7/HTR3D/GABRA3/CALHM1/TAS2R13/TAS2R4/PLCB4/TAS2R3/TAS2R8/TAS1R2/PLCB2/SCNN1G/TAS2R14/P2RY1/TAS2R19/TAS2R20/PRKACB/PLCB3/TAS2R43/GABBR1/SCN2A/TAS2R46/ENTPD2/TAS2R50/P2RX3/TAS1R1/P2RY4/P2RX2/TAS2R1	73
KEGG	hsa04080	Neuroactive ligand-receptor interaction	268/5183	362/8144	1.095e-05	0.0006098	0.0004593	CTSG/ADORA2A/P2RX1/S1PR1/F2RL1/F2RL2/QRFP/P2RY2/P2RY13/NPS/GHRL/RXFP4/THRA/HTR1B/GH1/ADCYAP1R1/CHRNA6/CNR2/CSH1/ADORA2B/FPR1/PATE4/HRH4/GRIA1/KISS1/RXFP1/GHRHR/TRH/GABRR1/BDKRB1/TRPV1/TAC3/DRD5/GRM8/CNR1/HRH2/CHRNB3/GIPR/PARD3/GRIA4/GLRB/C3AR1/PRLHR/C5AR1/AVPR1A/GRIK5/MLN/LHB/SSTR3/OPRK1/F2/TBXA2R/NMUR2/HTR1F/GHRH/GRM4/HTR1A/MTNR1A/TAAR6/GRIN3A/CHRNA5/CHRNB1/CHRM3/ADCYAP1/GABRA2/GRIA2/FSHB/CHRNB2/MC2R/MCHR1/PPY/NMUR1/NPBWR2/HCRTR2/CHRNA9/KNG1/ADRA1D/LPAR2/TAC4/CHRNB4/VIPR1/PENK/MAS1/GPHA2/NPY5R/GABRA4/IAPP/PLG/VGF/GRIK1/SLURP1/CCKAR/AVP/INSL5/NPSR1/CHRNA1/AVPR1B/FPR3/CHRM1/SSTR2/HTR1D/SSTR1/TAAR1/CHRNA4/GRIK4/P2RY10/GABRP/CHRNA7/GLRA3/KISS1R/GALP/ADRA2A/EDN3/THRB/GRM7/GALR2/P2RX7/GABRA1/PRL/GRP/P2RY11/GCG/OXT/GALR1/TAAR5/TAAR9/S1PR3/GHSR/HTR1E/RXFP3/NPFF/GABRD/PMCH/RLN2/GLP1R/OPRL1/HCRTR1/NPBWR1/TACR2/HTR2A/C5/PATE1/NMBR/NPY1R/PTGER2/GABRA6/CALCA/HTR2B/HCRT/LEP/RXFP2/GRM1/LEPR/TAC1/S1PR2/GRIN2B/NPY2R/TACR3/PTGFR/GPR156/EDNRB/GRIK2/PDYN/GPR35/GPR83/AGTR2/CHRNA2/RLN3/LPAR6/GABBR2/PRLH/CRHR1/GABRA5/PTGER4/TAAR2/GLP2R/CHRNA3/GRIN2C/TSPO/GABRG2/OXTR/NPVF/GABRR3/GABRA3/NPFFR2/ADRA2C/LPAR1/EDN2/GNRH1/PRSS1/TRHR/GIP/FSHR/DRD4/CCK/GRM3/CGA/UTS2/GRIN3B/PATE2/GRIN2A/MLNR/EDN1/QRFPR/APLNR/AGTR1/DRD3/GRM5/GRPR/CHRM2/ADRA1B/SST/SSTR5/P2RY1/POMC/BDKRB2/ADORA3/C3/DRD1/NR3C1/FPR2/GABBR1/PTAFR/BRS3/NTSR1/LHCGR/GH2/ADM2/UCN3/GRID1/GABRB2/ADM/GLRA1/LYPD6/ADRA1A/NMS/TSHB/F2RL3/SCTR/NPB/MC1R/ADRA2B/GRIK3/PTGIR/CHRM4/MTNR1B/NPW/INSL3/CORT/PTH1R/ADRB2/SCT/ADRB3/PTH2R/HRH3/P2RX3/HTR7/GLRA2/CHRM5/DRD2/PYY/HTR5A/NPY/ADRB1/GRID2/SSTR4/P2RY4/P2RX2	268
KEGG	hsa04725	Cholinergic synapse	92/5183	113/8144	2.654e-05	0.001266	0.0009538	GNGT2/PIK3CD/GNB3/CREB3L2/ITPR1/MAPK3/CHRNA6/SLC18A3/FYN/CREB3L4/GNG11/CAMK2A/GNAO1/GNAI3/ADCY4/PRKACA/KCNQ2/CAMK2B/CHRM3/CHRNB2/CACNA1A/ADCY5/CAMK2G/CHRNB4/CREB5/CHRM1/CHRNA4/SLC5A7/AKT2/KCNQ3/CHRNA7/PIK3R2/ITPR2/NRAS/ADCY3/MAPK1/CHAT/GNGT1/CACNA1S/PIK3R5/GNG4/PIK3R1/HRAS/ADCY6/ADCY2/CREB3L3/KRAS/CHRNA3/ADCY8/GNB4/KCNJ12/PLCB1/KCNJ14/KCNQ1/CREB3/GNAQ/GNG2/MAP2K1/KCNJ3/PIK3R6/BCL2/CACNA1B/GNAI1/ADCY7/GNG7/PLCB4/GNG8/PIK3CG/PLCB2/CHRM2/PRKACB/PIK3R3/PLCB3/KCNJ4/GNG3/PIK3CB/KCNQ5/ACHE/GNB1/GNG5/KCNQ4/FOS/CHRM4/ADCY1/GNG10/KCNJ2/PRKCB/CHRM5/KCNJ6/ATF4/CREB1/CAMK4	92
KEGG	hsa04015	Rap1 signaling pathway	160/5183	210/8144	5.491e-05	0.002292	0.001727	CTNND1/ADORA2A/RAPGEF3/ITGAL/RASSF5/PIK3CD/RAPGEF1/FGF21/FGF6/CALML3/SIPA1L2/ACTB/FGF1/TLN2/CALML6/PARD6B/CALML4/MAPK3/ENAH/EVL/ADORA2B/FPR1/KDR/PDGFA/RAPGEF2/PRKD3/FGFR3/CALML5/CNR1/HGF/PARD3/CDC42/MAGI1/FGF4/GNAO1/TLN1/GNAI3/ADCY4/INS/PLCE1/ITGB3/ITGAM/LPAR5/FGF17/FGFR4/ADCY5/NGFR/ARAP3/LPAR2/FGF5/FGF10/RAPGEF4/ANGPT4/RAC1/MET/AKT2/RAPGEF5/MAPK12/EPHA2/FLT4/PIK3R2/DOCK4/ITGB2/NRAS/SIPA1L1/FGF22/PFN2/ADCY3/PLCG1/MAPK1/CDH1/FGF19/RRAS/MAP2K2/PDGFB/PIK3R1/FGF3/HRAS/RAF1/GRIN2B/ADCY6/EGFR/CALM1/RALB/ADCY2/BCAR1/TIAM1/MAP2K6/KRAS/ADCY8/PLCB1/PDGFC/ANGPT2/PDGFD/RAP1B/VAV2/FGFR1/CALM2/APBB1IP/LAT/GNAQ/LPAR1/PARD6A/KIT/MAP2K1/PFN1/EGF/PFN4/GNAI1/ADCY7/PRKCZ/ITGB1/LCP2/PLCB4/FGF16/GRIN2A/INSR/IGF1R/RAC2/FGFR2/PLCB2/SIPA1/CTNNB1/ITGA2B/P2RY1/RASGRP3/ID1/PIK3R3/GNAS/PLCB3/RAP1GAP/RAP1A/MAPK14/FGF2/PRKD1/RAPGEF6/PIK3CB/MAP2K3/PDGFRA/RAC3/VAV1/EFNA3/F2RL3/KITLG/FGF18/SIPA1L3/PRKCI/TEK/VEGFC/ADCY1/CALM3/FGF8/PDGFRB/BRAF/PRKCB/KRIT1/CSF1R/DRD2/RALGDS/ACTG1	160
KEGG	hsa04934	Cushing syndrome	121/5183	155/8144	6.812e-05	0.002528	0.001904	AIP/TCF7/E2F1/CYP11B1/HSD3B1/ARNT/CREB3L2/ITPR1/MAPK3/CACNA1G/WNT8A/PDE8A/CREB3L4/LEF1/FZD6/FZD10/PDE11A/CDKN2B/KCNA4/CDKN1A/CAMK2A/WNT2/CYP11A1/GNAI3/ADCY4/WNT11/STAR/CACNA1H/PRKACA/AIPL1/CAMK2B/MC2R/TCF7L1/ADCY5/CDKN2A/CAMK2G/SP1/FZD8/CREB5/WNT10A/CYP17A1/NCEH1/PDE8B/FZD2/AXIN2/WDR5/CYP21A2/KCNK3/CDK6/NR4A1/ORAI1/ITPR2/ADCY3/MAPK1/LDLR/PBX1/WNT3A/CACNA1S/WNT7A/MAP2K2/ATF2/ADCY6/EGFR/WNT9B/ADCY2/CRHR1/ASH2L/CREB3L3/ADCY8/PLCB1/E2F3/KCNK2/WNT5A/DVL1/RAP1B/CREB3/USP8/GNAQ/WNT2B/MAP2K1/AXIN1/HSD3B2/MRAP/GNAI1/ADCY7/CDK2/PLCB4/AGTR1/PLCB2/NR5A1/CDKN2C/FZD4/CTNNB1/POMC/RBBP5/PRKACB/MEN1/GNAS/TCF7L2/PLCB3/WNT9A/FH/RAP1A/APC/WNT7B/WNT1/E2F2/WNT4/WNT16/CCNE1/DVL3/ADCY1/BRAF/CACNA1I/CDKN1B/AHR/RB1/SCARB1/ATF4/CREB1/FZD5	121
KEGG	hsa04916	Melanogenesis	82/5183	101/8144	8.813e-05	0.002771	0.002087	TCF7/CALML3/CREB3L2/MITF/CALML6/CALML4/MAPK3/WNT8A/TYRP1/CREB3L4/LEF1/CALML5/FZD6/FZD10/CAMK2A/WNT2/GNAO1/GNAI3/ADCY4/WNT11/PRKACA/CAMK2B/TCF7L1/ADCY5/TYR/CAMK2G/FZD8/WNT10A/DCT/FZD2/EP300/NRAS/ADCY3/MAPK1/WNT3A/WNT7A/MAP2K2/HRAS/RAF1/ADCY6/EDNRB/WNT9B/CALM1/ADCY2/CREB3L3/KRAS/ADCY8/PLCB1/WNT5A/DVL1/CALM2/CREB3/GNAQ/KIT/WNT2B/MAP2K1/GNAI1/ADCY7/PLCB4/EDN1/PLCB2/FZD4/CTNNB1/POMC/PRKACB/GNAS/TCF7L2/PLCB3/WNT9A/CREBBP/WNT7B/WNT1/WNT4/KITLG/WNT16/MC1R/DVL3/ADCY1/CALM3/PRKCB/CREB1/FZD5	82
KEGG	hsa04659	Th17 cell differentiation	87/5183	108/8144	9.383e-05	0.002771	0.002087	CD247/CD3D/IL2RB/CD3G/LCK/CD3E/IL1B/RORA/IL27RA/IFNG/IFNGR2/IL21/ZAP70/JAK1/NFATC2/IL27/IL23R/STAT5A/IL6R/MAPK3/IL2/HLA-DMB/SMAD2/IL17A/RXRA/IL23A/RORC/NFKBIA/RARA/IL1R1/STAT3/TGFBR2/IL21R/NFKB1/HIF1A/IL4/HLA-DOA/IL6ST/IL22/NFATC1/IL2RA/MAPK10/IL4R/TBX21/MAPK12/RXRG/CD4/IL1RAP/HLA-DQA1/PLCG1/HLA-DRA/MAPK1/MAPK9/IL17F/HSP90AA1/STAT6/RUNX1/NFKBIB/FOXP3/IL12RB1/HLA-DQA2/LAT/IRF4/PPP3R1/PPP3CA/STAT1/NFKBIE/EBI3/HLA-DPB1/RELA/HLA-DOB/PPP3CC/HLA-DMA/PPP3CB/TGFBR1/SMAD4/MAPK14/HSP90AB1/STAT5B/PPP3R2/FOS/SMAD3/MTOR/RXRB/IL2RG/AHR/NFATC3	87
KEGG	hsa04970	Salivary secretion	76/5183	93/8144	0.0001047	0.002771	0.002087	LYZ/CST1/CALML3/ATP1A2/CST2/TRPV6/KCNMA1/CALML6/FXYD2/ITPR1/CALML4/LPO/ATP2B2/CST4/CALML5/ATP1A1/MUC5B/HTN3/PRB2/ADCY4/PRKACA/CHRM3/ADCY5/ADRA1D/HTN1/ATP1B1/PRKG2/ITPR2/ADCY3/DMBT1/CD38/ADCY6/SLC9A1/ATP2B3/SLC12A2/ATP1A4/CALM1/ADCY2/CST5/ADCY8/PLCB1/CALM2/AQP5/GNAQ/KCNN4/STATH/ADCY7/MUC7/PLCB4/AMY2B/PLCB2/PRB1/ADRA1B/PRKG1/PRH1/PRKACB/GNAS/PLCB3/SLC4A2/ATP2B4/PRH2/AMY2A/ADRA1A/ADCY1/CALM3/ATP1B2/GUCY1A2/BEST2/ADRB2/ATP1A3/PRKCB/ADRB3/NOS1/CST3/CAMP/ADRB1	76
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	73/5183	89/8144	0.0001133	0.002771	0.002087	CD247/CD3D/CD3G/TLR4/LCK/CD28/PDCD1/CD3E/RPS6KB2/PIK3CD/IFNG/IFNGR2/PTPN6/ZAP70/JAK1/NFATC2/MAPK3/RASGRP1/BATF/MAP3K3/BATF2/NFKBIA/STAT3/TICAM2/NFKB1/PTEN/HIF1A/NFATC1/AKT2/MAPK12/PIK3R2/CD4/ALK/NRAS/PLCG1/TRAF6/MAPK1/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/MAP2K6/KRAS/NFKBIB/TICAM1/CSNK2A1/LAT/TIRAP/PPP3R1/BATF3/MAP2K1/PPP3CA/EGF/CSNK2B/TLR2/STAT1/NFKBIE/RPS6KB1/TLR9/CSNK2A2/RELA/PPP3CC/PPP3CB/PIK3R3/MAPK14/PIK3CB/MAP2K3/PPP3R2/FOS/MTOR/CD274/NFATC3	73
KEGG	hsa05226	Gastric cancer	116/5183	149/8144	0.0001185	0.002771	0.002087	RPS6KB2/PIK3CD/TCF7/SHC1/E2F1/FGF21/FGF6/FGF1/TERC/MAPK3/LRP6/FRAT1/WNT8A/SMAD2/LEF1/FZD6/FZD10/RXRA/CDKN2B/GADD45G/HGF/FRAT2/RARB/CDKN1A/ERBB2/FGF4/TGFBR2/WNT2/MUC2/GRB2/WNT11/TP53/CTNNA3/FGF17/TCF7L1/CDH17/FZD8/SHC2/CSNK1A1L/WNT10A/FGF5/FZD2/GAB1/FGF10/AXIN2/SHC4/MET/AKT2/CDX2/RXRG/PIK3R2/TERT/CTNNA1/SHH/NRAS/FGF22/MAPK1/CDH1/WNT3A/WNT7A/FGF19/MAP2K2/PIK3R1/FGF3/HRAS/RAF1/REG4/EGFR/WNT9B/KRAS/TGFB2/E2F3/WNT5A/DVL1/WNT2B/MAP2K1/AXIN1/CSNK1A1/EGF/BCL2/RPS6KB1/CDK2/FGF16/FGFR2/CTNNA2/FZD4/CTNNB1/PIK3R3/TCF7L2/WNT9A/GADD45A/TGFBR1/APC/SMAD4/WNT7B/FGF2/SOS2/WNT1/E2F2/PIK3CB/WNT4/WNT16/CCNE1/FGF18/DVL3/SMAD3/MTOR/FGF8/POLK/BRAF/RXRB/CDKN1B/RB1/SOS1/FZD5/LRP5	116
KEGG	hsa05150	Staphylococcus aureus infection	78/5183	96/8144	0.0001245	0.002771	0.002087	KRT17/ITGAL/IL10/FCAR/FCGR2A/KRT14/KRT15/DEFA4/FGG/HLA-DMB/DEFB1/C1QB/FPR1/FCGR1A/DSG1/C1QA/C3AR1/C5AR1/MASP1/CFD/MBL2/KRT38/KRT39/ITGAM/KRT26/C2/KRT13/MASP2/KRT33A/HLA-DOA/KRT37/CFI/KRT28/PLG/DEFA6/KRT9/KRT32/FPR3/C4A/C4B/KRT31/KRT20/KRT16/ITGB2/KRT35/FCGR3B/HLA-DQA1/CFB/HLA-DRA/ICAM1/KRT34/C5/KRT40/C1QC/FCGR3A/KRT33B/KRT10/KRT19/KRT24/KRT23/HLA-DQA2/KRT27/CFH/C1R/HLA-DPB1/HLA-DOB/KRT18/HLA-DMA/DEFA5/C3/FPR2/PTAFR/KRT25/KRT36/SELPLG/DEFA1/DEFA1B/CAMP	78
KEGG	hsa04062	Chemokine signaling pathway	146/5183	192/8144	0.0001362	0.002844	0.002142	CCR7/CCR6/CXCR5/ITK/GNGT2/PIK3CD/CCR8/SHC1/ARRB2/CCL5/ELMO1/GRK6/GNB3/CCL23/CCL11/CX3CR1/CXCR4/CXCL9/XCL2/MAPK3/PRKCD/CCL18/CXCL1/CCL1/CXCL2/PPBP/CCL21/CXCR6/CCL7/XCL1/CCL15/GNG11/PARD3/NFKBIA/STAT3/CXCL6/CDC42/CXCL11/DOCK2/GNAI3/PAK1/ADCY4/GRB2/PTK2/NFKB1/CXCR3/PRKACA/CCL28/CCR5/CCL4/CCL14/FOXO3/ADCY5/CXCR2/FGR/CCL20/SHC2/ARRB1/CCL13/CXCL10/RAC1/SHC4/AKT2/XCR1/CXCL13/PIK3R2/CCR9/NRAS/ADCY3/PLCG1/MAPK1/CX3CL1/CXCL3/GNGT1/LYN/PIK3R5/CCR3/GNG4/PIK3R1/HRAS/RAF1/GRK1/ADCY6/CCR1/HCK/ADCY2/BCAR1/PTK2B/TIAM1/KRAS/ADCY8/GNB4/PLCB1/NFKBIB/CCL3/RAP1B/VAV2/GNAQ/GNG2/MAP2K1/PIK3R6/GRK7/CCL19/GNAI1/ADCY7/PRKCZ/GNG7/STAT1/PLCB4/GNG8/NCF1/RAC2/CCL17/RELA/PIK3CG/PLCB2/CCL27/PRKACB/PIK3R3/PLCB3/RAP1A/PLCG2/SOS2/CCR2/GNG3/PIK3CB/CCL2/RAC3/PXN/VAV1/ROCK1/CXCL14/CCR10/CCL16/GNB1/STAT5B/GNG5/CCL3L1/CCL3L3/ROCK2/ADCY1/BRAF/GNG10/PRKCB/CCR4/SOS1	146
KEGG	hsa04072	Phospholipase D signaling pathway	115/5183	148/8144	0.0001467	0.002881	0.00217	DGKA/RAPGEF3/FCER1G/PIK3CD/SHC1/CYTH1/GNA12/SYK/MAPK3/DGKB/GNA13/PDGFA/PLA2G4A/FYN/GRM8/AVPR1A/F2/ADCY4/DNM1/GRB2/GRM4/AGPAT2/INS/LPAR5/DGKZ/ADCY5/CXCR2/PLA2G4E/LPAR2/SHC2/FCER1A/PLA2G4D/AVP/MS4A2/DGKI/AVPR1B/GAB1/RAPGEF4/SHC4/AKT2/PIK3R2/GRM7/PLD1/NRAS/CYTH4/ADCY3/PLCG1/MAPK1/DNM3/PLA2G4C/TSC2/PIK3R5/RRAS/MAP2K2/GRM1/PDGFB/PIK3R1/HRAS/RAF1/ARF1/ADCY6/PTGFR/EGFR/TSC1/LPAR6/RALB/ADCY2/PTK2B/KRAS/ADCY8/ARF6/PLCB1/PDGFC/PDGFD/AGPAT4/RHEB/LPAR1/PLD2/KIT/MAP2K1/DGKQ/PIK3R6/EGF/ADCY7/GRM3/PLCB4/INSR/AGPAT5/PIK3CG/AGTR1/PLCB2/DGKD/GRM5/CYTH3/PIK3R3/GNAS/PLCB3/DGKE/DGKH/PLCG2/SOS2/CYTH2/PIK3CB/PLA2G4F/PDGFRA/KITLG/MTOR/ADCY1/PDGFRB/DNM2/PIP5K1B/GAB2/SOS1/PIP5K1A/RALGDS	115
KEGG	hsa04918	Thyroid hormone synthesis	62/5183	75/8144	0.0002412	0.004475	0.003371	ATP1A2/CREB3L2/GPX3/FXYD2/ITPR1/CANX/CREB3L4/TTR/ATP1A1/GPX6/ADCY4/PRKACA/TTF2/ADCY5/CREB5/SLC5A5/SLC26A4/ALB/HSP90B1/ATP1B1/DUOXA2/TPO/ITPR2/ADCY3/DUOX1/LRP2/ATF2/ADCY6/ATP1A4/ADCY2/CREB3L3/ADCY8/PLCB1/CREB3/GPX2/GNAQ/DUOX2/ADCY7/PLCB4/CGA/PLCB2/SERPINA7/PRKACB/TG/GNAS/PLCB3/GPX5/GPX1/IYD/GPX8/TTF1/TSHB/HSPA5/GSR/ADCY1/ATP1B2/ASGR1/ATP1A3/PRKCB/ASGR2/ATF4/CREB1	62
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	80/5183	100/8144	0.0002764	0.004859	0.00366	LTA/IL2RB/CCR7/CCR6/CXCR5/LTBR/IL10/TNF/CCR8/IL18/IL10RA/IL24/CCL5/IL10RB/CCL23/CCL11/CX3CR1/CXCR4/CXCL9/TNFSF14/IL6R/XCL2/IL2/CCL18/CXCL1/IL22RA1/CCL1/CXCL2/PPBP/TNFRSF1A/CCL21/CCL7/XCL1/TNFSF10/CCL15/CXCL6/CXCL11/IL19/TNFRSF10C/CXCR3/CCL28/CCR5/CCL4/CCL14/CXCR2/IL6ST/CCL20/IL2RA/CCL13/CXCL10/XCR1/CXCL13/CCR9/TNFRSF1B/CX3CL1/CXCL3/CCR3/TNFRSF10D/IL34/TNFRSF10A/CCR1/CCL3/CCL19/IL20RB/CCL17/IL18R1/CCL27/IL18RAP/CCR2/CCL2/IL20RA/CXCL14/CCR10/CCL16/CCL3L1/CCL3L3/IL2RG/CSF1R/CCR4/TNFRSF10B	80
KEGG	hsa04640	Hematopoietic cell lineage	79/5183	99/8144	0.0003515	0.005546	0.004177	CD3D/CD3G/CD1C/IL7R/MS4A1/CD3E/CD7/CD2/CD34/IL1B/CD5/TNF/CD22/CD1B/CD1E/ITGA5/CD59/DNTT/GP9/EPOR/IL6R/IL5/HLA-DMB/CD8B/CSF3R/FCGR1A/CD33/IL5RA/FLT3/IL1R1/CD19/CD36/ITGA6/CR1/ITGB3/ITGAM/IL4/CD37/HLA-DOA/THPO/CD9/CD44/CSF3/GP5/IL2RA/IL4R/MME/CD4/CSF2/GP1BA/IL11RA/ITGA1/HLA-DQA1/EPO/HLA-DRA/IL1R2/CD38/FLT3LG/CD1D/IL3/CD55/FCER2/CD1A/HLA-DQA2/CR2/KIT/ITGA4/CD14/HLA-DPB1/HLA-DOB/ITGA2B/HLA-DMA/CD8A/KITLG/ITGA3/IL7/CSF1R/CR1L/GP1BB	79
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	84/5183	106/8144	0.0003557	0.005546	0.004177	ARRB2/MMP14/SLC34A1/SLC34A3/ARHGEF1/CREB3L2/RUNX2/HBEGF/GNA12/ITPR1/MAPK3/LRP6/GNA13/CREB3L4/RXRA/NR4A2/CDKN1A/TRPV5/GNAI3/ADCY4/BGLAP/PRKACA/MMP17/GCM1/ADCY5/SP1/CREB5/CASR/ARRB1/SOST/GCM2/MAFB/RXRG/CYP24A1/PLD1/CYP27B1/KL/MEF2D/ITPR2/JUND/ADCY3/SLC9A3R1/MAPK1/SLC34A2/ARHGEF11/RAF1/ATF2/ADCY6/EGFR/ADCY2/MMP13/CREB3L3/ADCY8/PLCB1/FGFR1/CREB3/GNAQ/PLD2/MAP2K1/BCL2/GNAI1/AKAP13/ADCY7/MMP25/PLCB4/MEF2C/PLCB2/PRKACB/EGR1/GNAS/PLCB3/PTHLH/NACA/PDE4B/FOS/ADCY1/BRAF/PTH1R/RXRB/PRKCB/MMP16/ATF4/CREB1/LRP5	84
KEGG	hsa04014	Ras signaling pathway	172/5183	232/8144	0.0003653	0.005546	0.004177	FASLG/ETS1/GNGT2/RASSF5/PIK3CD/SHC1/FGF21/ZAP70/FGF6/CALML3/GNB3/FGF1/CALML6/ABL2/CALML4/PLA2G2D/MAPK3/BCL2L1/RASGRP1/KDR/PDGFA/PLA2G4A/PLA2G2F/FGFR3/CALML5/RAB5C/FLT3/HGF/GNG11/CDC42/FGF4/PAK1/GRB2/PLA2G1B/ETS2/NFKB1/PRKACA/INS/PLCE1/FGF17/FGFR4/RALBP1/NGFR/PLA2G4E/SHC2/NTF3/TGFA/PLA2G4D/FGF5/GAB1/FGF10/MAPK10/ANGPT4/RAC1/SHC4/MET/AKT2/RAPGEF5/EPHA2/FLT4/PLA2G2E/PIK3R2/RASAL2/RASA4/RGL2/PLD1/NRAS/PLA2G2C/PLA2G2A/RIN1/FGF22/SYNGAP1/PLCG1/MAPK1/PLA2G4C/GNGT1/RASGRF2/STK4/RASGRP4/MAPK9/FGF19/GNG4/RRAS/MAP2K2/PDGFB/PIK3R1/FGF3/FLT3LG/HRAS/RAF1/GRIN2B/PLA2G10/PLA2G5/EGFR/PLA2G6/CALM1/RALB/TIAM1/KRAS/PLA2G12A/GNB4/BDNF/ARF6/PDGFC/ANGPT2/RASAL1/NF1/PDGFD/RAP1B/PLA2G3/FGFR1/CALM2/ABL1/LAT/RASA3/GNG2/PLD2/KIT/PLA2G12B/MAP2K1/REL/KSR1/EGF/PAK4/GNG7/IGF2/FGF16/GRIN2A/INSR/GNG8/IGF1R/RAC2/FGFR2/NTRK2/RELA/RGL1/RASGRP3/PRKACB/PIK3R3/RASAL3/RAP1A/PLCG2/PAK2/FGF2/SOS2/TBK1/GNG3/PIK3CB/PLA2G4F/PDGFRA/RAC3/EXOC2/EFNA3/KITLG/GNB1/FGF18/GNG5/KSR2/TEK/RASA2/VEGFC/CALM3/FGF8/PDGFRB/PAK3/GNG10/PRKCB/HTR7/CSF1R/GAB2/SOS1/RALGDS	172
KEGG	hsa04972	Pancreatic secretion	81/5183	102/8144	0.0003985	0.005787	0.004359	CPB2/PNLIP/CELA3A/ATP1A2/KCNMA1/FXYD2/ITPR1/CELA2A/PLA2G2D/CTRB2/ATP2B2/PLA2G2F/CA2/CPA1/ATP1A1/ADCY4/CPA3/PLA2G1B/CEL/CHRM3/CLCA1/ADCY5/RAB3D/ATP2A1/SLC26A3/CCKAR/RAC1/CELA2B/ATP1B1/PLA2G2E/CTRL/CTRB1/ITPR2/PLA2G2C/PLA2G2A/ADCY3/CLCA4/CD38/ADCY6/SLC9A1/PLA2G10/ATP2B3/PLA2G5/SLC12A2/ATP1A4/CPB1/ADCY2/PLA2G12A/ADCY8/PLCB1/KCNQ1/RAP1B/PNLIPRP1/PLA2G3/GNAQ/PLA2G12B/PRSS1/SLC4A4/CELA3B/CCK/ADCY7/RYR2/PLCB4/AMY2B/RAB27B/PLCB2/GNAS/PLCB3/SLC4A2/ATP2B4/RAP1A/AMY2A/SCTR/TPCN2/ADCY1/ATP1B2/RAB11A/ATP1A3/SCT/PRKCB/CLCA2	81
KEGG	hsa04927	Cortisol synthesis and secretion	54/5183	65/8144	0.0004761	0.006626	0.004991	CYP11B1/HSD3B1/CREB3L2/ITPR1/CACNA1G/PDE8A/CREB3L4/KCNA4/CYP11A1/ADCY4/STAR/CACNA1H/PRKACA/MC2R/ADCY5/SP1/CREB5/CYP17A1/NCEH1/PDE8B/CYP21A2/KCNK3/NR4A1/ORAI1/ITPR2/ADCY3/LDLR/PBX1/CACNA1S/ATF2/ADCY6/ADCY2/CREB3L3/ADCY8/PLCB1/KCNK2/CREB3/GNAQ/HSD3B2/MRAP/ADCY7/PLCB4/AGTR1/PLCB2/NR5A1/POMC/PRKACB/GNAS/PLCB3/ADCY1/CACNA1I/SCARB1/ATF4/CREB1	54
KEGG	hsa04060	Cytokine-cytokine receptor interaction	214/5183	295/8144	0.0006111	0.008164	0.006149	FASLG/LTA/IL2RB/IL7R/CCR7/CCR6/TNFSF4/CXCR5/LTBR/IL32/TNFSF13/IL1B/IL10/TNF/TNFRSF13B/LTB/CCR8/CLCF1/IL27RA/IFNG/IL18/IFNGR2/IL21/IL10RA/IL12RB2/TNFRSF25/IL17RC/IL24/CD27/CCL5/IL25/IL10RB/EDAR/TNFRSF19/CCL23/CCL11/CX3CR1/CXCR4/CXCL9/EPOR/IL27/IL23R/TNFSF14/IL6R/IFNK/IL1F10/XCL2/IL5/GH1/IL2/IL13/ACVR1/CCL18/TSLP/IL1RL1/CSH1/CXCL1/TNFSF12/IL22RA1/TNFSF13B/CCL1/IL26/CSF3R/IFNA7/CXCL2/PPBP/GDF1/IL17A/TNFRSF1A/IL5RA/CCL21/CXCR6/IL23A/CCL7/XCL1/TNFSF10/CCL15/GDF3/IL1R1/CXCL6/CXCL11/TGFBR2/IL31/IL21R/IL19/GDF11/TNFRSF10C/CTF1/CXCR3/BMP10/AMHR2/CCL28/CCR5/CCL4/IL4/CCL14/BMP2/IL17B/CXCR2/IL6ST/NGFR/IL31RA/IL17RE/IL22/BMPR1B/TNFRSF17/CCL20/THPO/IFNA8/CSF3/IL12B/CNTF/BMP3/IL2RA/RELT/CCL13/CXCL10/GDF6/IL4R/TNFSF9/XCR1/CXCL13/TNFRSF4/CD4/CSF2/IL1RAP/CCR9/PRL/IL9/IL11RA/EPO/TNFRSF1B/CD40/GDF9/IL15/CX3CL1/CXCL3/TNFSF18/AMH/IL1R2/IL16/CCR3/LEP/LEPR/IL17F/TNFRSF10D/IL34/CSF2RB/TNFRSF10A/CCR1/MSTN/BMP7/IL3/BMP5/BMP4/TGFB2/INHBA/TNFRSF8/CCL3/TNFRSF11B/IL12RB1/BMPR1A/IL15RA/GDF2/CCL19/GDF5/IL33/EBI3/EDA2R/CD70/IL20RB/CCL17/IL18R1/IL17C/LIFR/CCL27/BMP15/IL17RB/ACVR1B/INHBC/IL1RN/TGFBR1/TNFRSF18/IFNA4/IFNA14/IL1RL2/GH2/CD40LG/IL18RAP/LIF/INHA/CCR2/CCL2/IL20RA/CXCL14/TNFRSF13C/CCR10/CCL16/TNFSF8/TNFRSF21/BMP6/NODAL/CCL3L1/CCL3L3/ACVR1C/IFNAR2/GDF15/IL2RG/IL7/CSF1R/GDF10/INHBB/CCR4/TNFRSF10B	214
KEGG	hsa04976	Bile secretion	71/5183	89/8144	0.000706	0.009069	0.006831	SLC10A1/CYP3A4/ATP1A2/UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/NR0B2/UGT1A8/SLC22A7/UGT1A4/FXYD2/NR1H4/UGT1A3/SLCO1B1/ABCG8/CA2/RXRA/ABCG5/ATP1A1/ADCY4/SLC22A8/SLC10A2/PRKACA/SLC2A1/ADCY5/UGT2B7/AQP8/NCEH1/UGT1A1/EPHX1/SLC4A5/UGT2B11/ATP1B1/BAAT/SULT2A1/SLCO1A2/ADCY3/LDLR/SLCO1B3/UGT2A3/ADCY6/SLC9A1/UGT2B10/ATP1A4/ADCY2/SLC9A3/ADCY8/SLC22A1/SLC4A4/KCNN2/ABCC3/ADCY7/CYP7A1/SLC27A5/PRKACB/GNAS/SLC4A2/UGT2B15/AQP9/ABCB11/SCTR/ABCC2/ADCY1/UGT2A1/ATP1B2/AQP4/ATP1A3/SCT/SCARB1	71
KEGG	hsa04926	Relaxin signaling pathway	99/5183	129/8144	0.0009159	0.01133	0.008534	GNGT2/PIK3CD/SHC1/ARRB2/GNB3/CREB3L2/RXFP4/MAPK3/SMAD2/RXFP1/CREB3L4/MMP9/GNG11/NFKBIA/TGFBR2/GNAO1/GNAI3/ADCY4/GRB2/NFKB1/PRKACA/GNA15/MMP1/ADCY5/COL1A1/SHC2/CREB5/ARRB1/INSL5/MAPK10/SHC4/AKT2/MAPK12/PIK3R2/COL4A2/NRAS/ADCY3/COL4A4/RXFP3/MAPK1/RLN2/GNGT1/MAPK9/GNG4/RXFP2/MAP2K2/PIK3R1/HRAS/RAF1/ATF2/ADCY6/COL3A1/EGFR/EDNRB/RLN3/ADCY2/MAP2K4/MMP13/CREB3L3/KRAS/ADCY8/GNB4/PLCB1/CREB3/GNG2/MAP2K1/GNAI1/ADCY7/PRKCZ/GNG7/PLCB4/GNG8/COL4A3/EDN1/RELA/PLCB2/NOS2/PRKACB/PIK3R3/GNAS/PLCB3/TGFBR1/MAPK14/MMP2/SOS2/GNG3/PIK3CB/GNB1/GNG5/FOS/VEGFC/ADCY1/INSL3/ACTA2/GNG10/NOS1/SOS1/ATF4/CREB1	99
KEGG	hsa04925	Aldosterone synthesis and secretion	77/5183	98/8144	0.0009981	0.01191	0.008968	CALML3/ATP1A2/HSD3B1/CREB3L2/CALML6/ITPR1/CALML4/CACNA1G/CYP11B2/ATP2B2/CREB3L4/PRKD3/CALML5/ATP1A1/NR4A2/CAMK2A/CYP11A1/ADCY4/DAGLB/KCNJ5/STAR/CACNA1H/PRKACA/CAMK2B/MC2R/ADCY5/CAMK2G/CREB5/CYP21A2/KCNK3/ATP1B1/NR4A1/ORAI1/ITPR2/ADCY3/LDLR/CACNA1S/KCNK9/ATF2/ADCY6/ATP2B3/ATP1A4/CALM1/PDE2A/ADCY2/CREB3L3/ADCY8/PLCB1/NPR1/CALM2/CREB3/GNAQ/DAGLA/HSD3B2/ADCY7/PLCB4/AGTR1/PLCB2/POMC/PRKACB/GNAS/PLCB3/ATP2B4/PRKD1/LIPE/ADCY1/CALM3/ATP1B2/CACNA1I/ATP1A3/PRKCB/CAMK1G/PRKCE/SCARB1/ATF4/CREB1/CAMK4	77
KEGG	hsa05163	Human cytomegalovirus infection	165/5183	225/8144	0.001126	0.01261	0.009496	FASLG/RPS6KB2/GNGT2/CALR/PIK3CD/IL1B/TNF/HLA-E/E2F1/IL10RA/TAP1/CCL5/CALML3/IL10RB/JAK1/GNB3/ARHGEF1/CREB3L2/CXCR4/NFATC2/CALML6/IL6R/GNA12/ITPR1/CALML4/MAPK3/GNA13/CREB3L4/IFNA7/CALML5/TNFRSF1A/GNG11/NFKBIA/IL1R1/STAT3/CDKN1A/GNAO1/GNAI3/HLA-F/TAP2/ADCY4/GRB2/RIPK1/TP53/PTK2/NFKB1/PRKACA/ITGB3/CCR5/CCL4/ADCY5/CXCR2/CDKN2A/SP1/CREB5/FADD/IFNA8/NFATC1/RAC1/AKT2/CASP8/MAPK12/HLA-B/PIK3R2/CDK6/ITPR2/NRAS/ADCY3/MAPK1/TRAF5/CX3CL1/GNGT1/TSC2/CCR3/PTGER2/GNG4/ARHGEF11/MAP2K2/PIK3R1/HRAS/RAF1/ATF2/ADCY6/EGFR/EIF4EBP1/CCR1/CASP3/TSC1/CALM1/ADCY2/BCAR1/B2M/PTK2B/CREB3L3/MAP2K6/KRAS/CASP9/PTGER4/ADCY8/GNB4/CYCS/MDM2/PLCB1/E2F3/PTGS2/CCL3/CALM2/CREB3/RHEB/GNAQ/GNG2/ARHGEF12/PPP3R1/MAP2K1/PPP3CA/GNAI1/AKAP13/ADCY7/GNG7/RPS6KB1/PLCB4/GNG8/RAC2/RELA/PLCB2/CTNNB1/PPP3CC/PPP3CB/PRKACB/PIK3R3/GNAS/PLCB3/IFNA4/IFNA14/MAPK14/SOS2/TBK1/GNG3/E2F2/PIK3CB/PDGFRA/CCL2/RAC3/PXN/ROCK1/GNB1/ITGAV/GNG5/PPP3R2/CCL3L1/CCL3L3/TAPBP/ROCK2/MTOR/ADCY1/CALM3/IRF3/GNG10/PRKCB/RB1/BID/NFATC3/SOS1/ATF4/CREB1	165
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	156/5183	212/8144	0.001186	0.01261	0.009496	AIP/RPS6KB2/PIK3CD/MIRLET7D/E2F1/RPS6KA1/GSTT2B/IKBKE/CYP2B6/ARRB2/FGF6/CYP3A4/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/ARNT/UGT1A10/UGT1A8/CREB3L2/UGT1A4/STAT5A/MAPK3/GSTA5/UGT1A3/GSTA4/GSTT2/CREB3L4/KLF5/NR1I3/RXRA/STAT3/FGF4/GNAI3/ADCY4/GSTM2/GRB2/NFKB1/PRKACA/AIPL1/FGF17/CHRNB2/CACNA1A/ADCY5/UGT2B7/CHRNA9/CHRNB4/KLF4/CREB5/MIR29A/FGF5/ARRB1/UGT1A1/FGF10/EPHX1/EPHX3/CHRNA4/AKT2/UGT2B11/CHRNA7/HSP90B1/RXRG/PIK3R2/ESR1/NRAS/FGF22/MIRLET7A1/ADCY3/MAPK1/KPNA7/GSTA2/PAQR5/CACNA1S/UGT2A3/GSTA1/MAP2K2/PIK3R1/FGF3/HRAS/RAF1/ATF2/ADCY6/EGFR/EIF4EBP1/UGT2B10/HSP90AA1/MIR29C/MIRLET7G/ADCY2/CREB3L3/KRAS/DLL3/CHRNA3/ADCY8/MIRLET7I/KPNB1/PAQR8/CREB3/MGST1/MIRLET7F2/MAP2K1/EGF/BCL2/CACNA1B/MIRLET7E/GNAI1/ADCY7/MIRLET7A2/RPS6KB1/PAQR7/FGF16/CCND3/RELA/PGR/MGST2/CDC6/KPNA4/PRKACB/PIK3R3/GNAS/GSTM4/UGT2B15/RPS6KA2/DLL4/NOTCH2/KPNA6/GSTT1/FGF2/SOS2/GSTM3/WNT1/PIK3CB/MIR29B2/CYP1A1/HSP90AB1/MIR29B1/PTGES3/FGF18/STAT5B/FOS/MTOR/ADCY1/FGF8/UGT2A1/ADRB2/RXRB/PRKCB/CYP1B1/ADRB3/AHR/RB1/SOS1/ATF4/CREB1/ADRB1	156
KEGG	hsa04660	T cell receptor signaling pathway	81/5183	104/8144	0.00121	0.01261	0.009496	CD247/CD3D/CD3G/LCK/CD28/PDCD1/CD3E/ITK/PIK3CD/IL10/TNF/IFNG/PTPN6/ZAP70/PTPRC/NFATC2/MAPK3/RASGRP1/IL5/IL2/CD8B/FYN/CTLA4/NFKBIA/CDC42/DLG1/PAK1/GRB2/NFKB1/IL4/NFATC1/BCL10/MAPK10/AKT2/MAP3K8/MAPK12/PIK3R2/CD4/ICOS/CSF2/MAP3K14/NRAS/PLCG1/MAPK1/CARD11/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/KRAS/MALT1/NFKBIB/VAV2/LAT/PPP3R1/MAP2K1/PPP3CA/PAK4/LCP2/NFKBIE/CBLB/RELA/NCK2/PPP3CC/CD8A/PPP3CB/PIK3R3/TEC/MAPK14/CD40LG/PAK2/SOS2/PIK3CB/VAV1/PPP3R2/FOS/NCK1/PAK3/NFATC3/SOS1	81
KEGG	hsa04971	Gastric acid secretion	61/5183	76/8144	0.001246	0.01261	0.009496	CALML3/ATP1A2/ACTB/CALML6/ITPR1/CALML4/GAST/CALML5/CA2/HRH2/ATP1A1/CAMK2A/GNAI3/ADCY4/KCNJ1/PRKACA/CAMK2B/CHRM3/MYLK/ADCY5/CAMK2G/ATP4B/EZR/SSTR2/ATP1B1/KCNJ16/ITPR2/KCNE2/ADCY3/KCNJ15/ADCY6/SLC9A1/ATP1A4/CALM1/ADCY2/ADCY8/PLCB1/KCNK2/KCNQ1/CALM2/GNAQ/KCNJ10/GNAI1/ADCY7/PLCB4/PLCB2/SST/PRKACB/GNAS/PLCB3/SLC4A2/SLC26A7/ADCY1/CALM3/ATP1B2/ATP1A3/KCNJ2/PRKCB/SLC9A4/ATP4A/ACTG1	61
KEGG	hsa05133	Pertussis	61/5183	76/8144	0.001246	0.01261	0.009496	TLR4/IL1B/IL10/TNF/PYCARD/ITGA5/CALML3/NLRP3/C4BPA/CALML6/CALML4/MAPK3/NOD1/C1QB/CALML5/C1QA/IL23A/SERPING1/CXCL6/TICAM2/GNAI3/NFKB1/CASP1/ITGAM/C2/IL12B/MAPK10/SFTPA2/C4A/C4B/IRF8/MAPK12/IRAK4/ITGB2/TRAF6/MAPK1/C5/MAPK9/C1QC/C4BPB/CASP3/CALM1/TICAM1/CFL1/LY96/CALM2/TIRAP/GNAI1/ITGB1/C1R/CD14/RELA/CFL2/NOS2/SFTPA1/C3/IRF1/MAPK14/FOS/CALM3/IRF3	61
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	113/5183	150/8144	0.001381	0.01347	0.01014	RAPGEF3/PLN/CALML3/ATP1A2/MYH6/SCN1B/CREB3L2/CALML6/MYH7/FXYD2/CALML4/MAPK3/CACNG1/SCN5A/ATP2B2/CACNA2D3/CACNG5/CREB3L4/MYL4/CALML5/PPP2R5C/ATP1A1/PPP2R2C/CAMK2A/GNAI3/PPP1R1A/ADCY4/TNNT2/PRKACA/CAMK2B/RPS6KA5/SLC8A1/SCN7A/ADCY5/ADRA1D/CAMK2G/CREB5/ATP2A1/CACNG8/PPP2R5A/RAPGEF4/PPP2R5E/AKT2/ATP1B1/MAPK12/TNNC1/CACNA2D1/ADCY3/MAPK1/PPP2R2A/CACNA1S/PIK3R5/PPP2R2D/ATF2/ADCY6/SLC9A1/PPP2R5B/ATP2B3/MYL2/ATP1A4/AGTR2/CALM1/ADCY2/CREB3L3/ADCY8/CACNG4/PLCB1/KCNQ1/CALM2/CREB3/PPP2CB/GNAQ/PPP2R5D/TPM3/PIK3R6/BCL2/GNAI1/ADCY7/RYR2/PLCB4/PIK3CG/AGTR1/PLCB2/ADRA1B/PRKACB/PPP2R1A/GNAS/CACNB1/PLCB3/ATP2B4/SLC8A3/MAPK14/SLC8A2/ADRA1A/PPP2R3A/CACNG6/CACNA2D2/CACNB4/ADCY1/PPP2R3C/CALM3/PPP2CA/CACNG2/ATP1B2/ADRB2/ATP1A3/MYL3/TPM4/SCN4B/ATF4/CREB1/ADRB1/CACNG7	113
KEGG	hsa04912	GnRH signaling pathway	73/5183	93/8144	0.001411	0.01347	0.01014	MMP14/CALML3/CALML6/HBEGF/ITPR1/CALML4/MAPK3/PRKCD/MAP3K3/PLA2G4A/CALML5/CDC42/CAMK2A/LHB/ADCY4/GRB2/PRKACA/CAMK2B/FSHB/ADCY5/PLA2G4E/CAMK2G/PLA2G4D/MAPK10/MAPK12/PLD1/MAP3K2/ITPR2/NRAS/ADCY3/MAPK1/PLA2G4C/CACNA1S/MAPK9/MAP2K2/HRAS/RAF1/ADCY6/EGFR/CALM1/ADCY2/MAP2K4/PTK2B/MAP2K6/KRAS/ADCY8/PLCB1/MAP3K1/CALM2/GNAQ/PLD2/GNRH1/MAP2K1/ADCY7/PLCB4/CGA/PLCB2/PRKACB/EGR1/GNAS/PLCB3/MAP3K4/MAPK14/MAPK7/MMP2/SOS2/MAP2K3/PLA2G4F/ADCY1/CALM3/PRKCB/SOS1/ATF4	73
KEGG	hsa04151	PI3K-Akt signaling pathway	251/5183	354/8144	0.001943	0.01802	0.01358	FASLG/IL2RB/LAMA3/TLR4/IL7R/MYB/RPS6KB2/GNGT2/PHLPP1/PIK3CD/PRKAA1/YWHAG/AREG/G6PC3/ITGA5/FGF21/FGF6/JAK1/GNB3/PCK2/FGF1/CREB3L2/EPOR/IL6R/TNXB/SYK/IBSP/VTN/MAPK3/BCL2L1/GH1/IL2/LAMA5/CSH1/KDR/PDGFA/LAMB4/CREB3L4/THBS3/FGFR3/CSF3R/IFNA7/PPP2R5C/RXRA/THBS4/CCND2/FLT3/HGF/GNG11/TNC/SGK1/PPP2R2C/CDKN1A/MAGI1/ERBB2/FGF4/CD19/GRB2/ITGB6/TP53/PTK2/NFKB1/PTEN/ITGA6/YWHAZ/INS/ITGB3/PCK1/LPAR5/ITGB4/FGF17/FGFR4/IL4/FOXO3/COL1A1/NGFR/LPAR2/PRKAA2/GYS2/CREB5/NTF3/TGFA/IFNA8/FGF5/PPP2R5A/CSF3/IL2RA/PHLPP2/FGF10/CHRM1/COL6A2/SGK2/ANGPT4/LAMA4/IL4R/RAC1/PPP2R5E/MET/AKT2/HSP90B1/EPHA2/FLT4/PKN1/PIK3R2/CDK6/RPS6/NR4A1/PRL/COL4A2/NRAS/ITGA1/ITGA11/FGF22/EPO/COL4A4/MAPK1/PPP2R2A/GNGT1/TSC2/EIF4E1B/PIK3AP1/ITGB7/PIK3R5/COMP/PPP2R2D/SPP1/FGF19/GNG4/COL9A2/G6PC/MAP2K2/CRTC2/PDGFB/PIK3R1/SGK3/FGF3/FLT3LG/TNN/HRAS/RAF1/ATF2/PPP2R5B/COL6A6/EGFR/EIF4EBP1/HSP90AA1/TSC1/LPAR6/IL3/CREB3L3/KRAS/CASP9/COL6A1/TCL1B/GNB4/MDM2/BDNF/PDGFC/ANGPT2/PDGFD/FGFR1/CREB3/IRS1/PPP2CB/ERBB3/RHEB/LPAR1/GNG2/KIT/PPP2R5D/MAP2K1/PIK3R6/PKN3/EGF/BCL2/ITGA4/ITGB1/GNG7/TLR2/RPS6KB1/THBS2/IGF2/CDK2/FGF16/INSR/LAMA2/GNG8/COL4A3/IGF1R/FGFR2/LAMA1/BCL2L11/CCND3/COL2A1/STK11/NTRK2/LAMC3/RELA/PIK3CG/CHRM2/ITGA2B/PIK3R3/PPP2R1A/EREG/COL9A3/IFNA4/IFNA14/GH2/FGF2/SOS2/CDC37/GNG3/PIK3CB/PDGFRA/PPP2R3A/HSP90AB1/EFNA3/KITLG/ITGA3/COL6A3/CCNE1/GNB1/FGF18/ITGB5/ITGAV/GNG5/FN1/TEK/GYS1/MTOR/VEGFC/RBL2/PPP2R3C/EIF4E2/FGF8/PPP2CA/PDGFRB/ITGA7/IFNAR2/CHAD/CDKN1B/GNG10/IL2RG/LAMB2/ITGA10/IL7/CSF1R/SOS1/ATF4/CREB1/VWF	251
KEGG	hsa04540	Gap junction	69/5183	88/8144	0.001997	0.01803	0.01358	ITPR1/MAPK3/PDGFA/GNAI3/ADCY4/GRB2/PRKACA/ADCY5/GJD2/TUBB/TUBA3C/PRKG2/MAP3K2/ITPR2/NRAS/ADCY3/MAPK1/TJP1/HTR2A/TUBA3E/HTR2B/MAP2K2/GRM1/PDGFB/TUBA4A/HRAS/RAF1/ADCY6/TUBA1A/EGFR/ADCY2/KRAS/TUBB3/ADCY8/TUBA3D/PLCB1/PDGFC/PDGFD/GNAQ/LPAR1/MAP2K1/EGF/GNAI1/ADCY7/PLCB4/TUBB8/TUBA8/TUBB2A/TUBA1B/PLCB2/GJA1/GRM5/PRKG1/PRKACB/DRD1/GNAS/PLCB3/MAPK7/SOS2/PDGFRA/ADCY1/PDGFRB/GUCY1A2/PRKCB/DRD2/SOS1/ADRB1/TUBA1C/MAP2K5	69
KEGG	hsa04724	Glutamatergic synapse	87/5183	114/8144	0.002474	0.02174	0.01638	GNGT2/GNB3/ITPR1/MAPK3/SLC1A3/PLA2G4A/GRIA1/GRM8/GNG11/SHANK3/GRIA4/GRIK5/GNAO1/GNAI3/ADCY4/GRM4/PRKACA/GRIN3A/GRIA2/GLUL/CACNA1A/ADCY5/PLA2G4E/SHANK2/GRIK1/PLA2G4D/GRIK4/GRM7/PLD1/ITPR2/SLC38A1/ADCY3/MAPK1/PLA2G4C/GNGT1/SLC1A7/GLS/GNG4/GRM1/GRIN2B/ADCY6/HOMER1/GRIK2/ADCY2/SLC1A6/ADCY8/GRIN2C/GNB4/PLCB1/GNAQ/GNG2/PLD2/PPP3R1/SLC17A6/KCNJ3/PPP3CA/GNAI1/ADCY7/GRM3/GNG7/PLCB4/GRIN3B/GRIN2A/GNG8/PLCB2/GRM5/GLS2/DLGAP1/PPP3CC/PPP3CB/PRKACB/GNAS/PLCB3/DLG4/SLC1A2/SLC17A8/GNG3/PLA2G4F/GNB1/GRIK3/GNG5/PPP3R2/HOMER2/ADCY1/GNG10/PRKCB/SLC17A7	87
KEGG	hsa04913	Ovarian steroidogenesis	42/5183	51/8144	0.002871	0.02459	0.01852	HSD3B1/PLA2G4A/LHB/CYP11A1/ADCY4/STAR/PRKACA/INS/FSHB/ADCY5/PLA2G4E/CYP17A1/PLA2G4D/ADCY3/LDLR/PLA2G4C/ADCY6/ADCY2/ADCY8/PTGS2/HSD3B2/FSHR/ADCY7/CGA/INSR/IGF1R/HSD17B1/CYP2J2/BMP15/PRKACB/GNAS/LHCGR/PLA2G4F/CYP1A1/BMP6/CYP19A1/ADCY1/HSD17B7/CYP1B1/SCARB1/HSD17B2/AKR1C3	42
KEGG	hsa05417	Lipid and atherosclerosis	156/5183	215/8144	0.003168	0.02646	0.01993	FASLG/TLR4/OLR1/PIK3CD/IL1B/TNF/XBP1/TLR6/LBP/CASP6/IL18/IKBKE/CYP2B6/PYCARD/CCL5/CALML3/CYP2C9/NLRP3/APOA4/ARHGEF1/NFATC2/CALML6/POU2F1/ITPR1/CALML4/MAPK3/BCL2L1/CXCL1/IFNA7/CALML5/PPARG/CXCL2/TNFRSF1A/RXRA/TNFSF10/MMP9/HSPA8/NFKBIA/STAT3/CDC42/TICAM2/CAMK2A/NCF4/CD36/SELE/TP53/PTK2/NFKB1/NCF2/CASP1/CAMK2B/MMP1/CAMK2G/IFNA8/NFATC1/IL12B/MAPK10/RAC1/AKT2/HSP90B1/NFE2L2/CASP8/MAPK12/RXRG/PIK3R2/IRAK4/MMP3/DDIT3/NRAS/CYP2A7/CD40/MAP3K5/PLCG1/TRAF6/MAPK1/ICAM1/ABCG1/LDLR/CXCL3/LYN/MAPK9/PIK3R1/HRAS/TNFRSF10A/VLDLR/CASP3/HSP90AA1/CALM1/MAP2K4/MAP2K6/KRAS/CASP9/CYCS/PLCB1/TICAM1/LY96/ABCA1/CCL3/RAP1B/VAV2/CALM2/TIRAP/CYBA/PPP3R1/POU2F3/HSPA1A/PPP3CA/HSPA2/BCL2/HSPA1L/TLR2/PLCB4/EIF2AK3/NCF1/CD14/RELA/PLCB2/CYP2J2/PPP3CC/PPP3CB/PIK3R3/POU2F2/PLCB3/RAP1A/IFNA4/IFNA14/HSPA4/MAPK14/CD40LG/TBK1/PIK3CB/MAP2K3/MIB1/CCL2/CYP1A1/HSP90AB1/VAV1/AGER/APOA1/HSPA5/APOB/PPP3R2/CCL3L1/CCL3L3/FOS/ROCK2/TRAF3/CALM3/ATF6/IRF3/RXRB/BID/NFATC3/TNFRSF10B/CYP2C8/ATF4	156
KEGG	hsa04024	cAMP signaling pathway	160/5183	221/8144	0.003278	0.0267	0.02011	ADORA2A/RAPGEF3/PIK3CD/FXYD1/PLN/CALML3/CNGB3/ATP1A2/CREB3L2/GHRL/CALML6/FXYD2/HTR1B/CALML4/MAPK3/ADCYAP1R1/ATP2B2/GRIA1/CREB3L4/CALML5/DRD5/MYL9/GIPR/ATP1A1/NFKBIA/GRIA4/CAMK2A/LHB/GNAI3/PAK1/ADCY4/HTR1F/NFKB1/CNGA4/HTR1A/PRKACA/PLCE1/GRIN3A/CAMK2B/ADCYAP1/GRIA2/FSHB/MC2R/ADCY5/CAMK2G/ARAP3/CNGA1/CREB5/ATP2A1/GPHA2/NFATC1/CNGB1/CHRM1/SSTR2/RAPGEF4/MAPK10/HTR1D/SSTR1/RAC1/AKT2/GLI3/ATP1B1/PIK3R2/EDN3/PDE3B/EP300/PLD1/ORAI1/GCG/OXT/ADCY3/GHSR/HTR1E/MAPK1/GLP1R/PPP1R1B/AMH/HCN4/CACNA1S/MAPK9/NPY1R/ACOX3/PTGER2/RRAS/MAP2K2/PIK3R1/RAF1/GRIN2B/ADCY6/SLC9A1/ATP2B3/ATP1A4/CALM1/GABBR2/ADCY2/CRHR1/CREB3L3/TIAM1/ADCY8/GRIN2C/SOX9/BDNF/OXTR/NPR1/RAP1B/VAV2/CALM2/CREB3/PLD2/EDN2/MAP2K1/GIP/FSHR/GNAI1/ADCY7/RYR2/CGA/GRIN3B/GRIN2A/RAC2/EDN1/RELA/CHRM2/SST/SSTR5/POMC/CNGA2/PRKACB/PIK3R3/DRD1/GNAS/ATP2B4/GABBR1/RAP1A/CNGA3/LHCGR/CREBBP/PIK3CB/RAC3/SUCNR1/TSHB/VAV1/ROCK1/PDE4B/PTCH1/LIPE/FOS/ROCK2/ADCY1/CALM3/ATP1B2/BRAF/ADRB2/ATP1A3/GPR119/DRD2/NPY/CREB1/ADRB1/CAMK4	160
KEGG	hsa05205	Proteoglycans in cancer	149/5183	205/8144	0.003474	0.02741	0.02065	FASLG/TLR4/RPS6KB2/PIK3CD/MIR10A/TNF/MIR21/CBL/PLAUR/ITGA5/PTPN6/ACTB/ARHGEF1/HBEGF/ITPR1/VTN/MAPK3/WNT8A/KDR/SMAD2/CAV3/IQGAP1/FZD6/FZD10/MMP9/HGF/STAT3/CDC42/CDKN1A/CAMK2A/ERBB2/WNT2/PAK1/GRB2/WNT11/TP53/PTK2/TWIST1/PRKACA/PLCE1/ITGB3/CAMK2B/DCN/HIF1A/HSPG2/COL1A1/ANK2/CAMK2G/FZD8/SMO/EZR/WNT10A/CD44/HOXD10/IL12B/FZD2/GAB1/RAC1/MET/AKT2/PDCD4/MAPK12/PIK3R2/RPS6/HPSE/SHH/PLAU/ESR1/LUM/ITPR2/NRAS/TIMP3/PLCG1/MAPK1/FRS2/WNT3A/ANK3/WNT7A/GPC1/RRAS/MAP2K2/PIK3R1/HRAS/RAF1/SLC9A1/FLNC/EGFR/WNT9B/CASP3/CAV1/CD63/TIAM1/KRAS/MDM2/TGFB2/WNT5A/TWIST2/IHH/VAV2/FGFR1/ERBB3/DDX5/NUDT16L1/ARHGEF12/WNT2B/MAP2K1/ANK1/ITGB1/TLR2/RPS6KB1/IGF2/IGF1R/SDC1/SDC2/FZD4/CTNNB1/PRKACB/PIK3R3/WNT9A/SDC4/PLCG2/MAPK14/MMP2/WNT7B/FGF2/SOS2/PPP1R12B/WNT1/PIK3CB/PXN/VAV1/ROCK1/WNT4/WNT16/HPSE2/PTCH1/ITGB5/ITGAV/FN1/RDX/ROCK2/MTOR/BRAF/MIR10B/PRKCB/CAV2/SOS1/FZD5/ACTG1	149
KEGG	hsa04662	B cell receptor signaling pathway	64/5183	82/8144	0.003529	0.02741	0.02065	PIK3CD/CD22/IFITM1/CD72/PTPN6/NFATC2/SYK/MAPK3/DAPP1/INPP5D/LILRB4/CD81/NFKBIA/CD19/GRB2/NFKB1/NFATC1/BCL10/RAC1/AKT2/PIK3R2/NRAS/MAPK1/LYN/CARD11/PIK3AP1/LILRA1/MAP2K2/PIK3R1/HRAS/RAF1/KRAS/MALT1/NFKBIB/LILRB5/LILRB1/VAV2/LILRA4/CD79A/CR2/CD79B/PPP3R1/MAP2K1/PPP3CA/NFKBIE/RAC2/RELA/PPP3CC/RASGRP3/PPP3CB/PIK3R3/LILRB3/INPPL1/PLCG2/SOS2/PIK3CB/RAC3/VAV1/PPP3R2/FOS/PRKCB/LILRB2/NFATC3/SOS1	64
KEGG	hsa00140	Steroid hormone biosynthesis	49/5183	61/8144	0.003612	0.02742	0.02065	CYP11B1/CYP3A4/HSD3B1/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/CYP3A5/UGT1A3/CYP11B2/CYP11A1/AKR1D1/SULT1E1/AKR1C4/UGT2B7/HSD17B8/CYP17A1/AKR1C1/UGT1A1/CYP21A2/UGT2B11/SULT2B1/CYP7B1/HSD11B2/UGT2A3/UGT2B10/COMT/CYP3A7/HSD17B3/STS/HSD3B2/CYP7A1/LRTOMT/HSD17B1/UGT2B15/CYP1A1/SRD5A2/CYP19A1/HSD11B1L/UGT2A1/HSD17B7/CYP1B1/HSD17B2/AKR1C2/AKR1C3	49
KEGG	hsa04360	Axon guidance	133/5183	182/8144	0.004064	0.02946	0.02219	SSH3/PIK3CD/FES/LRRC4/EPHB2/CXCR4/NFATC2/EPHB6/PARD6B/MAPK3/ENAH/SEMA6B/EPHA5/PLXNA2/FYN/SEMA4G/NTN4/MYL9/PARD3/CDC42/CAMK2A/GNAI3/ROBO3/PAK1/RGS3/EFNB2/PTK2/SEMA3B/EPHA7/SEMA5B/CAMK2B/ABLIM2/SEMA3F/EPHB1/LIMK2/CAMK2G/BMPR1B/LRRC4C/SMO/SEMA3A/SEMA4A/NTN1/RAC1/DCC/MET/EPHA2/NGEF/PIK3R2/UNC5A/UNC5B/SRGAP3/SHH/PLXNB2/NRAS/PLCG1/MAPK1/MYL5/EPHB4/RRAS/PIK3R1/HRAS/RAF1/DPYSL5/SEMA3D/BMP7/SEMA6A/TRPC6/KRAS/UNC5C/SLIT2/PLXNB3/PLXNA4/CFL1/SEMA5A/WNT5A/PLXNB1/PLXNA1/ROBO1/ABL1/PARD6A/ARHGEF12/SLIT1/PPP3R1/SRGAP1/ABLIM3/PPP3CA/PAK4/GNAI1/SLIT3/PRKCZ/ITGB1/RAC2/SEMA6D/DPYSL2/SEMA6C/NCK2/CFL2/SSH1/PPP3CC/NEO1/LIMK1/EFNB3/PPP3CB/PIK3R3/SEMA3G/NTNG2/EPHA3/PLCG2/NTN3/PAK2/MYL12A/PLXNA3/PIK3CB/RAC3/ROCK1/BOC/WNT4/EFNA3/PTCH1/UNC5D/SEMA4D/ROBO2/PPP3R2/CDK5/SSH2/ROCK2/EPHA1/NCK1/TRPC4/PAK3/NFATC3/NRP1/SEMA4B	133
KEGG	hsa05224	Breast cancer	109/5183	147/8144	0.00413	0.02946	0.02219	RPS6KB2/PIK3CD/TCF7/SHC1/E2F1/FGF21/FGF6/FGF1/MAPK3/LRP6/FRAT1/WNT8A/LEF1/FZD6/FZD10/JAG2/GADD45G/FRAT2/CDKN1A/ERBB2/FGF4/WNT2/GRB2/WNT11/TP53/PTEN/HES5/HEYL/FGF17/TCF7L1/SP1/FZD8/SHC2/CSNK1A1L/WNT10A/FGF5/FZD2/FGF10/AXIN2/SHC4/AKT2/NOTCH4/FLT4/PIK3R2/CDK6/HES1/ESR1/NRAS/HEY1/FGF22/MAPK1/WNT3A/WNT7A/FGF19/MAP2K2/PIK3R1/FGF3/HRAS/RAF1/EGFR/WNT9B/KRAS/DLL3/BRCA2/E2F3/WNT5A/DVL1/FGFR1/KIT/WNT2B/MAP2K1/AXIN1/CSNK1A1/EGF/RPS6KB1/FGF16/NCOA1/IGF1R/PGR/NCOA3/FZD4/CTNNB1/PIK3R3/TCF7L2/WNT9A/GADD45A/APC/DLL4/NOTCH2/NFKB2/WNT7B/FGF2/SOS2/WNT1/E2F2/PIK3CB/WNT4/WNT16/FGF18/DVL3/FOS/MTOR/FGF8/POLK/BRAF/RB1/SOS1/FZD5/LRP5	109
KEGG	hsa05231	Choline metabolism in cancer	75/5183	98/8144	0.004227	0.02946	0.02219	RPS6KB2/DGKA/PIK3CD/CHKA/SLC44A1/MAPK3/DGKB/PDGFA/PLA2G4A/WASF3/SLC22A2/GRB2/DGKZ/HIF1A/PLA2G4E/SLC22A5/SP1/PLA2G4D/DGKI/MAPK10/RAC1/SLC5A7/AKT2/PIK3R2/PLD1/SLC44A5/NRAS/PLCG1/MAPK1/PLA2G4C/TSC2/MAPK9/MAP2K2/PDGFB/PIK3R1/HRAS/RAF1/EGFR/EIF4EBP1/SLC44A4/TSC1/KRAS/SLC22A1/PDGFC/PDGFD/RHEB/PLD2/MAP2K1/CHPT1/DGKQ/EGF/RPS6KB1/RAC2/DGKD/LYPLA1/PIK3R3/DGKE/DGKH/PCYT1A/SOS2/PIK3CB/PLA2G4F/PDGFRA/RAC3/SLC44A2/CHKB/FOS/MTOR/PDGFRB/PRKCB/PIP5K1B/SOS1/SLC44A3/PIP5K1A/RALGDS	75
KEGG	hsa04270	Vascular smooth muscle contraction	100/5183	134/8144	0.004233	0.02946	0.02219	ADORA2A/PRKCH/CALML3/ARHGEF1/KCNMA1/CALML6/GNA12/ITPR1/CALML4/KCNMB2/PLA2G2D/MAPK3/PRKCD/ADORA2B/GNA13/NPR2/PLA2G4A/PLA2G2F/CALML5/MYL9/AVPR1A/ADCY4/PLA2G1B/ACTG2/PRKACA/MYLK/ADCY5/PLA2G4E/ADRA1D/PLA2G4D/AVP/AVPR1B/MYH9/PLA2G2E/EDN3/MYH10/RAMP3/ITPR2/PLA2G2C/PLA2G2A/ADCY3/MAPK1/PLA2G4C/CACNA1S/CALCA/ARHGEF11/MAP2K2/RAF1/ADCY6/PLA2G10/PLA2G5/PLA2G6/KCNU1/CALM1/ADCY2/PLA2G12A/PPP1R14A/ADCY8/PLCB1/NPR1/PLA2G3/NPPC/CALM2/GNAQ/PLA2G12B/EDN2/ARHGEF12/CALD1/MAP2K1/MYL6/ADCY7/PLCB4/KCNMB4/EDN1/AGTR1/PLCB2/ADRA1B/PRKG1/KCNMB1/KCNMB3/PRKACB/GNAS/RAMP1/PLCB3/ADM2/PPP1R12B/ADM/PLA2G4F/ADRA1A/ROCK1/ROCK2/PTGIR/ADCY1/CALM3/GUCY1A2/BRAF/ACTA2/PRKCB/PRKCE/RAMP2	100
KEGG	hsa04720	Long-term potentiation	53/5183	67/8144	0.00464	0.03163	0.02382	RAPGEF3/RPS6KA1/CALML3/CALML6/ITPR1/CALML4/MAPK3/GRIA1/CALML5/CAMK2A/PPP1R1A/PRKACA/CAMK2B/GRIA2/CAMK2G/EP300/ITPR2/NRAS/MAPK1/MAP2K2/GRM1/HRAS/RAF1/GRIN2B/CALM1/KRAS/ADCY8/GRIN2C/PLCB1/RAP1B/CALM2/GNAQ/PPP3R1/MAP2K1/PPP3CA/PLCB4/GRIN2A/PLCB2/GRM5/PPP3CC/PPP3CB/PRKACB/PLCB3/RPS6KA2/RAP1A/CREBBP/PPP3R2/ADCY1/CALM3/BRAF/PRKCB/ATF4/CAMK4	53
KEGG	hsa04810	Regulation of actin cytoskeleton	157/5183	218/8144	0.005007	0.03345	0.02519	ITGAL/SSH3/PIK3CD/IQGAP3/MYL7/NCKAP1L/ITGA5/FGF21/FGF6/ITGAE/ACTB/ARHGEF1/FGF1/CXCR4/CYFIP1/GNA12/MAPK3/ENAH/GNA13/PDGFA/FGFR3/IQGAP1/DIAPH1/BDKRB1/MYL9/VCL/CDC42/FGF4/PAK1/BAIAP2/F2/IQGAP2/ITGAD/ITGB6/PIKFYVE/PTK2/GSN/ITGA6/INS/ITGB3/ITGAM/LPAR5/ITGB4/CHRM3/FGF17/FGFR4/MYLK/LIMK2/KNG1/GIT1/LPAR2/SPATA13/EZR/FGF5/FGF10/CHRM1/MYH9/RAC1/INSRR/MYL10/PIP4K2A/PIK3R2/MYH10/ITGB2/NRAS/ITGA1/ITGA11/FGF22/PFN2/MAPK1/MYL5/ITGB7/FGF19/RRAS/MAP2K2/PDGFB/PIK3R1/FGF3/HRAS/RAF1/ARPC4/SLC9A1/NCKAP1/EGFR/MYL2/BCAR1/CYFIP2/TIAM1/KRAS/CFL1/PDGFC/PDGFD/MYLPF/VAV2/FGFR1/ABI2/LPAR1/ARHGEF12/MAP2K1/PFN1/EGF/PAK4/PFN4/ITGA4/ITGB1/ARHGEF7/PIP4K2C/FGF16/RAC2/FGFR2/CFL2/CHRM2/SSH1/ITGA2B/LIMK1/BDKRB2/PIK3R3/APC/PAK2/MYL12A/FGF2/ACTR3C/SOS2/PPP1R12B/PIK3CB/PDGFRA/RAC3/PXN/ACTR2/FGD3/VAV1/ROCK1/ITGA3/TMSB4Y/FGF18/ITGB5/ITGAV/FN1/ARPC5L/RDX/SSH2/ROCK2/CHRM4/ACTR3B/FGF8/PDGFRB/ITGA7/BRAF/PAK3/PIP5K1B/ARHGEF4/ITGA10/ITGAX/CHRM5/SOS1/PIP5K1A/ACTG1	157
KEGG	hsa04713	Circadian entrainment	74/5183	97/8144	0.005158	0.03378	0.02544	GNGT2/CALML3/GNB3/CALML6/ITPR1/CALML4/MAPK3/PER1/NOS1AP/CACNA1G/ADCYAP1R1/GRIA1/CALML5/GNG11/GRIA4/CAMK2A/GNAO1/GNAI3/ADCY4/KCNJ5/CACNA1H/PRKACA/MTNR1A/CAMK2B/ADCYAP1/GRIA2/RPS6KA5/ADCY5/CAMK2G/RYR1/PRKG2/ADCY3/MAPK1/GNGT1/GNG4/GRIN2B/ADCY6/CALM1/ADCY2/ADCY8/GRIN2C/GNB4/PLCB1/CALM2/GNAQ/GNG2/PER3/KCNJ3/GNAI1/ADCY7/RYR2/GNG7/PLCB4/GRIN2A/GNG8/PLCB2/PRKG1/PRKACB/GNAS/PLCB3/GNG3/GNB1/GNG5/FOS/MTNR1B/ADCY1/CALM3/GUCY1A2/CACNA1I/GNG10/PRKCB/NOS1/KCNJ6/CREB1	74
KEGG	hsa05418	Fluid shear stress and atherosclerosis	103/5183	139/8144	0.005405	0.03472	0.02615	PIK3CD/MIR10A/IL1B/PRKAA1/TNF/IFNG/GSTT2B/PECAM1/CALML3/ACTB/CALML6/KLF2/CALML4/GSTA5/GSTP1/ACVR1/KDR/PDGFA/GSTA4/CAV3/GSTT2/CALML5/TNFRSF1A/SQSTM1/MMP9/IL1R1/SELE/GSTM2/TP53/PTK2/NFKB1/NCF2/ITGB3/BMPR1B/PRKAA2/CDH5/THBD/MAPK10/RAC1/AKT2/HSP90B1/NFE2L2/MAPK12/PIK3R2/HMOX1/MAP3K5/ICAM1/GSTA2/ARHGEF2/IL1R2/MAPK9/GSTA1/GPC1/PDGFB/PIK3R1/SUMO4/HSP90AA1/CAV1/CALM1/MAP2K4/MAP2K6/BMP4/NPPC/CALM2/MGST1/BMPR1A/NQO1/CYBA/SUMO3/BCL2/PRKCZ/TXN2/MEF2C/NCF1/RAC2/EDN1/SDC1/RELA/MGST2/SDC2/CTNNB1/ITGA2B/PIK3R3/GSTM4/SDC4/MAPK14/MAPK7/MMP2/GSTT1/GSTM3/PIK3CB/CCL2/RAC3/HSP90AB1/ASS1/SUMO2/ITGAV/FOS/CALM3/PLAT/CAV2/MAP2K5/ACTG1	103
KEGG	hsa04911	Insulin secretion	66/5183	86/8144	0.00633	0.03989	0.03005	ATP1A2/CREB3L2/STX1A/KCNMA1/FXYD2/KCNMB2/ADCYAP1R1/CREB3L4/GCK/ATP1A1/CAMK2A/PDX1/ADCY4/PRKACA/RAB3A/INS/CAMK2B/CHRM3/ADCYAP1/SLC2A1/ADCY5/FFAR1/CAMK2G/CREB5/CCKAR/RAPGEF4/ATP1B1/GCG/ADCY3/GLP1R/CACNA1S/ATF2/ADCY6/KCNN3/ATP1A4/KCNU1/TRPM4/ADCY2/CREB3L3/PCLO/ADCY8/PLCB1/SNAP25/CREB3/GNAQ/KCNN4/GIP/KCNN2/CCK/ADCY7/RYR2/PLCB4/KCNMB4/PLCB2/KCNMB1/KCNMB3/PRKACB/GNAS/PLCB3/ADCY1/ATP1B2/ATP1A3/PRKCB/GPR119/ATF4/CREB1	66
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	54/5183	69/8144	0.006471	0.04002	0.03015	HPGDS/GSTT2B/CYP3A43/CYP3A4/CYP2C9/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/GSTA5/NAT2/CYP3A5/UGT1A3/GSTP1/GSTA4/GSTT2/GSTM2/UGT2B7/CYP2C18/UGT1A1/EPHX1/UGT2B11/SULT2A1/CYP2C19/CYP2A7/GSTA2/UGT2A3/GSTA1/CYP2A13/UGT2B10/NAT1/CYP3A7/PTGS2/MGST1/SULT1A3/SULT1A4/MGST2/GSTM4/UGT2B15/GSTK1/GSTT1/SULT1A2/GSTM3/CYP1A1/HSD11B1L/UGT2A1/CYP1B1/AKR1C2/SULT1A1/CYP2C8	54
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	159/5183	222/8144	0.006728	0.04081	0.03074	LTA/ETS1/CD3D/IL2RB/CD3G/LCK/CD3E/LTBR/CALR/ITGAL/PIK3CD/SPI1/TNF/HLA-E/VDAC2/E2F1/ZFP36/MMP7/JAK1/CREB3L2/NFATC2/TLN2/STAT5A/MAPK3/BCL2L1/IL2/HLA-DMB/SMAD2/CANX/MAP3K3/CREB3L4/TNFRSF1A/CDKN2B/CCND2/NFKBIA/IL1R1/CDKN1A/DLG1/SLC25A31/TGFBR2/TLN1/HLA-F/ADCY4/FDPS/TP53/ETS2/NFKB1/PRKACA/PTEN/SLC2A1/ADCY5/HLA-DOA/PTTG2/CDKN2A/CREB5/NFATC1/IL2RA/CCNA1/MAPK10/AKT2/HLA-B/PIK3R2/MSX2/ANAPC10/TERT/CD4/ITGB2/EP300/CSF2/MSX1/MAD2L1/MAP3K14/NRAS/HLA-DQA1/CD40/ADCY3/HLA-DRA/MAPK1/ICAM1/IL15/CRTC3/CDC26/IL1R2/GPS2/MAPK9/MAP2K2/CRTC2/PIK3R1/HRAS/ATF2/ADCY6/CRTC1/ADCY2/B2M/MAP2K4/CREB3L3/KRAS/ADCY8/TGFB2/TSPO/E2F3/BUB3/MAP3K1/ATM/CREB3/HLA-DQA2/IL15RA/PPP3R1/MAP2K1/PPP3CA/CDC16/ADCY7/TCF3/CDK2/CDC20/CCND3/HLA-DPB1/RELA/HLA-DOB/CDKN2C/PPP3CC/HLA-DMA/PPP3CB/PRKACB/PIK3R3/EGR1/CHEK2/TGFBR1/SMAD4/RAN/VAC14/NFKB2/CREBBP/KAT5/E2F2/PIK3CB/TBPL1/TNFRSF13C/CCNE1/POLB/STAT5B/BUB1B/PPP3R2/FOS/SMAD3/ADCY1/MAD1L1/IL2RG/ANAPC11/RB1/RELB/NFATC3/ANAPC2/KAT2B/ATF4/XPO1/TRRAP/CREB1/NRP1	159
KEGG	hsa05206	MicroRNAs in cancer	218/5183	310/8144	0.006907	0.04081	0.03074	MIR32/PIK3CD/MIR200B/MIR10A/BCL2L2/MIR19A/MIR143/MIR145/MIR18A/MIR17/MIR21/MIRLET7D/SHC1/E2F1/MIR199B/SERPINB5/DNMT1/ITGA5/MIR96/MIR15B/ABCC1/DNMT3B/MIR345/TNXB/MAPK3/CDC25B/MIR34C/MIR205/MIR200A/PDGFA/MIR193B/FGFR3/MIR183/MIR30E/MIR494/MIR34B/MIR99A/MIR223/MIR20A/MIR155/CCND2/MIR129-2/MMP9/BMF/TNC/MIR128-1/STAT3/CDKN1A/MIR16-2/ERBB2/MIR373/HDAC5/MIRLET7C/GRB2/MIR1-1/TP53/NFKB1/MIR150/PTEN/MIR375/MIR129-1/MIR124-2/ITGB3/MIR206/MIR30A/MIR26A1/BMI1/RPS6KA5/MIR19B1/MIR124-3/MIR100/ST14/CDKN2A/MIR195/EZR/ZEB1/CD44/MIR29A/HOXD10/MIR210/MIR27A/MIR92A1/MIR520G/EZH2/MIR483/SHC4/MET/MIR520C/NOTCH4/MARCKS/PDCD4/MIR135A2/PIK3R2/CDK6/MIR135B/MIR125B2/MIR520H/MIR133B/MIR602/EP300/PLAU/HMOX1/CYP24A1/MIR124-1/NRAS/TIMP3/MIRLET7A1/MIR449A/PLCG1/MIR520B/MAPK1/MIR122/SOX4/WNT3A/MIR200C/MIR181A2/MIR181B2/HDAC1/GLS/MIR106B/MAP2K2/MIR9-3/PDGFB/PIK3R1/TNN/HRAS/RAF1/PIM1/EGFR/ZEB2/CASP3/MIR29C/MIRLET7G/MIR7-3/IRS2/KRAS/MIR128-2/MIR125A/MIR107/MDM2/TGFB2/MIR324/E2F3/CDCA5/PTGS2/MIRLET7I/MIR133A2/ATM/IRS1/ABL1/ERBB3/DNMT3A/VIM/MIRLET7F2/HMGA2/MAP2K1/MIR30C2/PAK4/BCL2/MIRLET7E/MIRLET7A2/DICER1/MIR9-1/BCL2L11/MIR152/SOCS1/GLS2/MIR181C/SLC45A3/PIK3R3/MIR146A/APC/PLCG2/MIR199A2/NOTCH2/MAPK7/CREBBP/MIR192/SOS2/MIR133A1/E2F2/PIK3CB/MIR29B2/PDGFRA/HDAC2/MIR29B1/MIR520E/MIR520A/ROCK1/ZFPM2/EFNA3/MIR7-2/UBE2I/MIR222/MDM4/CCNE1/SPRY2/RDX/MTOR/PDGFRB/MIR30C1/MIR10B/CDKN1B/PRKCB/CYP1B1/MIR15A/MIR137/MIR23B/MMP16/PRKCE/MIR126/MIR214/MIR330/MIR27B/MIR331/SOS1/MIR181B1/MIR30D	218
KEGG	hsa05218	Melanoma	56/5183	72/8144	0.007086	0.04081	0.03074	PIK3CD/E2F1/FGF21/FGF6/FGF1/MITF/MAPK3/PDGFA/GADD45G/HGF/CDKN1A/FGF4/TP53/PTEN/FGF17/CDKN2A/FGF5/FGF10/MET/AKT2/PIK3R2/CDK6/NRAS/FGF22/MAPK1/CDH1/FGF19/MAP2K2/PDGFB/PIK3R1/FGF3/HRAS/RAF1/EGFR/KRAS/MDM2/E2F3/PDGFC/PDGFD/FGFR1/MAP2K1/EGF/FGF16/IGF1R/PIK3R3/GADD45A/FGF2/E2F2/PIK3CB/PDGFRA/FGF18/FGF8/PDGFRB/POLK/BRAF/RB1	56
KEGG	hsa04020	Calcium signaling pathway	171/5183	240/8144	0.007087	0.04081	0.03074	ADORA2A/P2RX1/VDAC2/PLN/ITPKB/FGF21/FGF6/CALML3/FGF1/CXCR4/CALML6/ITPR1/CALML4/CACNA1G/ADORA2B/KDR/PDGFA/ATP2B2/FGFR3/CALML5/BDKRB1/CASQ1/DRD5/HRH2/HGF/TRDN/AVPR1A/SLC25A31/CAMK2A/ERBB2/FGF4/ADCY4/ITPKA/TBXA2R/CACNA1H/STIM2/PRKACA/PLCE1/GNA15/CAMK2B/CHRM3/FGF17/FGFR4/CACNA1A/SLC8A1/MYLK/STIM1/ADRA1D/CAMK2G/PHKB/PLCZ1/ATP2A1/CACNA1E/FGF5/CCKAR/RYR1/ORAI2/AVPR1B/FGF10/CHRM1/PDE1A/MET/CHRNA7/MST1/FLT4/TNNC1/P2RX7/ORAI1/ITPR2/FGF22/ADCY3/PLCG1/TACR2/HTR2A/CACNA1S/CD38/FGF19/HTR2B/GRM1/PDGFB/FGF3/TACR3/PTGFR/ATP2B3/EGFR/EDNRB/CALM1/ADCY2/PTK2B/GDNF/NTRK3/PDE1B/ADCY8/GRIN2C/CASQ2/PLCB1/PDGFC/OXTR/PDGFD/FGFR1/CALM2/ERBB3/TPCN1/GNAQ/PPP3R1/PLCD3/PPP3CA/TRHR/EGF/CACNA1B/MCOLN2/ADCY7/RYR2/PLCB4/FGF16/GRIN2A/FGFR2/NTRK2/AGTR1/PLCB2/MCOLN1/TNNC2/GRM5/GRPR/CHRM2/ADRA1B/HRC/PPP3CC/NOS2/BDKRB2/PPP3CB/PRKACB/DRD1/GNAS/PLCD4/PLCB3/PHKG1/MCOLN3/ATP2B4/SLC8A3/PTAFR/NTSR1/LHCGR/PLCG2/FGF2/PLCD1/SLC8A2/PDGFRA/ADRA1A/RET/TPCN2/FGF18/PPP3R2/VEGFC/ADCY1/CALM3/FGF8/PDGFRB/CACNA1I/ADRB2/PRKCB/CAMK1G/ADRB3/NOS1/P2RX3/HTR7/CHRM5/HTR5A/ADRB1/CAMK4/P2RX2	171
KEGG	hsa04919	Thyroid hormone signaling pathway	90/5183	121/8144	0.007569	0.04242	0.03195	PIK3CD/PLN/ATP1A2/MYH6/ACTB/PFKFB2/MYH7/FXYD2/THRA/MAPK3/SLCO1C1/RXRA/DIO3/ATP1A1/RCAN2/TP53/PRKACA/PLCE1/ITGB3/HIF1A/SLC2A1/PLCZ1/ATP2A1/AKT2/NOTCH4/ATP1B1/RXRG/TBC1D4/PIK3R2/MED16/THRB/EP300/SLC16A10/ESR1/NRAS/PLCG1/MAPK1/TSC2/HDAC1/MAP2K2/PIK3R1/HRAS/RAF1/SLC9A1/ATP1A4/MED12L/KRAS/CASP9/BMP4/MDM2/PLCB1/DIO2/HDAC3/RHEB/PLCD3/MAP2K1/STAT1/FOXO1/PLCB4/NCOA1/NCOA2/PLCB2/NCOA3/CTNNB1/GATA4/PRKACB/PIK3R3/NCOR1/PLCD4/PLCB3/MED24/RCAN1/PLCG2/NOTCH2/CREBBP/PLCD1/PIK3CB/SIN3A/HDAC2/WNT4/ITGAV/MTOR/ATP1B2/ATP1A3/RXRB/PRKCB/MED27/MED4/KAT2B/ACTG1	90
KEGG	hsa05214	Glioma	58/5183	75/8144	0.007695	0.04242	0.03195	PIK3CD/SHC1/E2F1/CALML3/CALML6/CALML4/MAPK3/PDGFA/CALML5/GADD45G/CDKN1A/CAMK2A/GRB2/TP53/PTEN/CAMK2B/CDKN2A/CAMK2G/SHC2/TGFA/SHC4/AKT2/PIK3R2/CDK6/NRAS/PLCG1/MAPK1/MAP2K2/PDGFB/PIK3R1/HRAS/RAF1/EGFR/CALM1/KRAS/MDM2/E2F3/CALM2/MAP2K1/EGF/IGF1R/PIK3R3/GADD45A/PLCG2/SOS2/E2F2/PIK3CB/PDGFRA/MTOR/CALM3/PDGFRB/POLK/BRAF/PRKCB/CAMK1G/RB1/SOS1/CAMK4	58
KEGG	hsa04611	Platelet activation	92/5183	124/8144	0.007842	0.04242	0.03195	FCER1G/P2RX1/PIK3CD/FCGR2A/PTGS1/ACTB/ARHGEF1/P2RY12/GP9/TLN2/ITPR1/SYK/MAPK3/RASGRP1/FGG/GNA13/PLA2G4A/FYN/TLN1/GNAI3/F2/ADCY4/TBXA2R/FGA/PRKACA/ITGB3/MYLK/STIM1/ADCY5/COL1A1/PLA2G4E/PLA2G4D/GP5/SNAP23/AKT2/MAPK12/PIK3R2/PRKG2/ORAI1/GP1BA/ITPR2/ADCY3/MAPK1/PLA2G4C/LYN/PIK3R5/PIK3R1/ADCY6/COL3A1/TBXAS1/FERMT3/ADCY2/FGB/ADCY8/PLCB1/RAP1B/APBB1IP/VAMP8/GNAQ/ARHGEF12/PIK3R6/GNAI1/ADCY7/PRKCZ/ITGB1/LCP2/PLCB4/PIK3CG/PLCB2/ITGA2B/PRKG1/P2RY1/PRKACB/PIK3R3/GNAS/PLCB3/RAP1A/PLCG2/MAPK14/MYL12A/PIK3CB/PLA2G4F/ROCK1/F2RL3/PRKCI/ROCK2/PTGIR/ADCY1/GUCY1A2/GP1BB/VWF/ACTG1	92
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	105/5183	143/8144	0.007958	0.04242	0.03195	PIK3CD/TCF7/MEIS1/JAK1/ID3/MAPK3/JARID2/ACVR1/WNT8A/SMAD2/FGFR3/FZD6/FZD10/STAT3/ISL1/WNT2/OTX1/GRB2/WNT11/PAX6/ID4/PCGF2/HAND1/BMI1/FGFR4/IL6ST/ONECUT1/BMPR1B/FZD8/KLF4/WNT10A/HOXD1/ESRRB/FZD2/SMAD5/SKIL/LHX5/AXIN2/NEUROG1/AKT2/TBX3/MAPK12/PIK3R2/DLX5/NRAS/ZFHX3/RIF1/MAPK1/WNT3A/POU5F1B/WNT7A/MAP2K2/PIK3R1/HRAS/RAF1/WNT9B/KRAS/SOX2/BMP4/PCGF1/INHBA/WNT5A/DVL1/FGFR1/REST/BMPR1A/WNT2B/MAP2K1/AXIN1/HOXA1/PCGF5/TCF3/IGF1R/HESX1/FGFR2/LIFR/SMAD1/FZD4/CTNNB1/POU5F1/ID1/PIK3R3/HOXB1/ACVR1B/INHBC/WNT9A/ID2/APC/SMAD4/MAPK14/WNT7B/FGF2/LIF/WNT1/PIK3CB/WNT4/WNT16/PCGF6/DVL3/NODAL/SMAD3/ACVR1C/SMAD9/INHBB/FZD5	105
KEGG	hsa04664	Fc epsilon RI signaling pathway	53/5183	68/8144	0.008082	0.04242	0.03195	FCER1G/PIK3CD/TNF/SYK/MAPK3/IL5/IL13/INPP5D/PLA2G4A/FYN/ALOX5AP/GRB2/IL4/PLA2G4E/FCER1A/PLA2G4D/MS4A2/MAPK10/RAC1/AKT2/MAPK12/PIK3R2/CSF2/NRAS/PLCG1/MAPK1/PLA2G4C/LYN/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/MAP2K4/IL3/MAP2K6/KRAS/VAV2/LAT/MAP2K1/LCP2/RAC2/PIK3R3/PLCG2/MAPK14/SOS2/PIK3CB/MAP2K3/PLA2G4F/RAC3/VAV1/GAB2/SOS1	53
KEGG	hsa05225	Hepatocellular carcinoma	122/5183	168/8144	0.008128	0.04242	0.03195	RPS6KB2/PIK3CD/TCF7/SHC1/E2F1/GSTT2B/ACTB/TERC/MAPK3/GSTA5/BCL2L1/LRP6/GSTP1/FRAT1/WNT8A/SMAD2/GSTA4/GSTT2/LEF1/FZD6/FZD10/GADD45G/HGF/FRAT2/CDKN1A/TGFBR2/WNT2/GSTM2/GRB2/WNT11/TP53/PTEN/TCF7L1/CDKN2A/FZD8/SHC2/CSNK1A1L/WNT10A/TGFA/FZD2/GAB1/SMARCB1/AXIN2/SHC4/MET/AKT2/NFE2L2/PIK3R2/CDK6/TERT/PHF10/HMOX1/TXNRD2/NRAS/SMARCA4/PLCG1/MAPK1/GSTA2/WNT3A/WNT7A/GSTA1/MAP2K2/PIK3R1/SMARCC1/HRAS/RAF1/EGFR/WNT9B/KRAS/TGFB2/E2F3/WNT5A/DVL1/MGST1/NQO1/WNT2B/MAP2K1/AXIN1/CSNK1A1/RPS6KB1/IGF2/IGF1R/BRD7/MGST2/FZD4/CTNNB1/PIK3R3/TCF7L2/GSTM4/WNT9A/GADD45A/TGFBR1/APC/SMAD4/PLCG2/WNT7B/GSTT1/SOS2/GSTM3/WNT1/SMARCD3/E2F2/PIK3CB/TXNRD1/ACTL6A/ARID1A/WNT4/WNT16/DVL3/ACTL6B/SMAD3/MTOR/POLK/BRAF/PRKCB/RB1/SMARCD2/SOS1/SMARCE1/FZD5/LRP5/ACTG1	122
KEGG	hsa04975	Fat digestion and absorption	35/5183	43/8144	0.009211	0.04733	0.03565	MOGAT2/PNLIP/DGAT1/APOA4/NPC1L1/PLA2G2D/PLA2G2F/ABCG8/FABP2/ABCG5/CD36/PLA2G1B/AGPAT2/CEL/CLPS/ACAT1/FABP1/PLA2G2E/PLA2G2C/PLA2G2A/LIPF/PLA2G10/PLA2G5/PLA2G12A/SLC27A4/ABCA1/SLC27A1/PNLIPRP1/PLA2G3/MTTP/PLA2G12B/DGAT2/APOA1/APOB/SCARB1	35
KEGG	hsa04728	Dopaminergic synapse	97/5183	132/8144	0.01014	0.0508	0.03826	GNGT2/DDC/ARRB2/SLC18A1/CALML3/GNB3/CREB3L2/CLOCK/CALML6/ITPR1/CALML4/GRIA1/CREB3L4/CALML5/TH/DRD5/PPP2R5C/GNG11/PPP2R2C/GRIA4/CAMK2A/GNAO1/GNAI3/SLC18A2/KCNJ5/PRKACA/CAMK2B/GRIA2/CACNA1A/ADCY5/CAMK2G/CREB5/PPP2R5A/ARRB1/MAPK10/PPP2R5E/AKT2/MAPK12/SCN1A/ITPR2/PPP2R2A/GNGT1/PPP1R1B/MAPK9/PPP2R2D/GNG4/KIF5B/SLC6A3/ATF2/GRIN2B/PPP2R5B/CALM1/COMT/CREB3L3/GNB4/PLCB1/CALM2/CREB3/PPP2CB/GNAQ/GNG2/PPP2R5D/KCNJ3/PPP3CA/DRD4/CACNA1B/GNAI1/GNG7/PLCB4/GRIN2A/GNG8/LRTOMT/KIF5C/PLCB2/DRD3/PPP3CC/PPP3CB/PRKACB/PPP2R1A/DRD1/GNAS/PLCB3/MAPK14/GNG3/PPP2R3A/GNB1/GNG5/FOS/PPP2R3C/CALM3/PPP2CA/GNG10/PRKCB/KCNJ6/DRD2/ATF4/CREB1	97
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	59/5183	77/8144	0.01019	0.0508	0.03826	TCF7/ITGA5/ACTB/SGCA/CACNG1/CACNA2D3/CACNG5/LEF1/DSC2/ITGB6/CTNNA3/ITGA6/ITGB3/ITGB4/SLC8A1/DSG2/TCF7L1/ATP2A1/CACNG8/CDH2/CACNA2D1/CTNNA1/ITGA1/ITGA11/CACNA1S/ITGB7/SGCG/DSP/CACNG4/PKP2/SGCD/SGCB/ITGA4/RYR2/ITGB1/LAMA2/LAMA1/CTNNA2/GJA1/DES/CTNNB1/ITGA2B/CACNB1/TCF7L2/SLC8A3/SLC8A2/CACNG6/ACTN2/CACNA2D2/ITGA3/CACNB4/ITGB5/ITGAV/CACNG2/ITGA7/ACTN3/ITGA10/CACNG7/ACTG1	59
KEGG	hsa04935	Growth hormone synthesis, secretion and action	88/5183	119/8144	0.01064	0.05226	0.03936	PIK3CD/SHC1/SOCS2/CREB3L2/GHRL/STAT5A/ITPR1/MAPK3/GH1/CSH1/CREB3L4/GHRHR/STAT3/SSTR3/GNAI3/ADCY4/GRB2/PTK2/GHRH/PRKACA/ADCY5/SHC2/CREB5/SSTR2/MAPK10/SSTR1/SHC4/AKT2/MAPK12/PIK3R2/EP300/IGFBP3/ITPR2/NRAS/ADCY3/GHSR/PLCG1/MAPK1/CACNA1S/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/ATF2/ADCY6/ADCY2/BCAR1/IRS2/MAP2K4/CREB3L3/MAP2K6/KRAS/ADCY8/PLCB1/MAP3K1/CREB3/IRS1/GNAQ/MAP2K1/GNAI1/ADCY7/STAT1/IGFALS/PLCB4/PLCB2/SOCS1/SST/SSTR5/PRKACB/PIK3R3/GNAS/PLCB3/PLCG2/MAPK14/GH2/CREBBP/SOS2/PIK3CB/MAP2K3/STAT5B/FOS/MTOR/ADCY1/PRKCB/SOS1/ATF4/CREB1	88
KEGG	hsa05210	Colorectal cancer	65/5183	86/8144	0.01215	0.05884	0.04432	RPS6KB2/MSH6/PIK3CD/TCF7/AREG/APPL1/MAPK3/SMAD2/LEF1/GADD45G/CDKN1A/TGFBR2/GRB2/TP53/TCF7L1/TGFA/AXIN2/MAPK10/RAC1/DCC/AKT2/PIK3R2/NRAS/MAPK1/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/CASP3/RALB/MSH3/KRAS/CASP9/CYCS/TGFB2/MSH2/MAP2K1/AXIN1/EGF/BCL2/RPS6KB1/PMAIP1/RAC2/BCL2L11/CTNNB1/PIK3R3/EREG/TCF7L2/GADD45A/TGFBR1/APC/SMAD4/SOS2/PIK3CB/RAC3/BBC3/FOS/SMAD3/MTOR/POLK/BRAF/SOS1/RALGDS	65
KEGG	hsa05142	Chagas disease	76/5183	102/8144	0.01262	0.06023	0.04537	FASLG/CD247/CD3D/CD3G/TLR4/CD3E/CALR/PIK3CD/IL1B/IL10/TNF/TLR6/IFNG/IFNGR2/CCL5/MAPK3/IL2/C1QB/SMAD2/TNFRSF1A/C1QA/NFKBIA/ACE/PPP2R2C/TGFBR2/GNAO1/GNAI3/NFKB1/GNA15/KNG1/FADD/IL12B/MAPK10/AKT2/CASP8/MAPK12/PIK3R2/IRAK4/TRAF6/MAPK1/PPP2R2A/MAPK9/PPP2R2D/C1QC/PIK3R1/MAP2K4/CFLAR/TGFB2/PLCB1/TICAM1/CCL3/SERPINE1/PPP2CB/GNAQ/GNAI1/TLR2/PLCB4/TLR9/RELA/PLCB2/NOS2/BDKRB2/PIK3R3/PPP2R1A/C3/GNAS/PLCB3/TGFBR1/MAPK14/PIK3CB/CCL2/CCL3L1/CCL3L3/FOS/ADCY1/PPP2CA	76
KEGG	hsa05165	Human papillomavirus infection	230/5183	331/8144	0.01321	0.06139	0.04624	FASLG/LAMA3/RPS6KB2/PIK3CD/TCF7/TNF/HLA-E/E2F1/IKBKE/ATP6V0E2/ITGA5/JAK1/CREB3L2/PARD6B/TNXB/IBSP/VTN/MAPK3/RBL1/LAMA5/WNT8A/MAML1/LAMB4/CREB3L4/THBS3/IFNA7/FZD6/ATP6V0A1/DLG2/FZD10/TNFRSF1A/PPP2R5C/THBS4/CCND2/PARD3/TNC/PPP2R2C/CDC42/CDKN1A/MAGI1/DLG1/WNT2/HLA-F/GRB2/WNT11/ITGB6/TP53/PTK2/NFKB1/PRKACA/PTEN/HES5/ITGA6/HEYL/ATP6V0D2/ITGB3/ITGB4/TCF7L1/UBE3A/COL1A1/FZD8/CSNK1A1L/CREB5/WNT10A/FADD/HES6/IFNA8/PPP2R5A/FZD2/CCNA1/AXIN2/COL6A2/LAMA4/ATP6V0A4/PPP2R5E/AKT2/NOTCH4/CASP8/ATP6V1B1/HLA-B/PIK3R2/CDK6/TERT/ATP6V1B2/EP300/HES1/COL4A2/NRAS/ITGA1/HEY1/ITGA11/ATP6V1C1/COL4A4/SLC9A3R1/MAPK1/ATP6V1G3/PPP2R2A/ATP6V0D1/IRF9/TSC2/WNT3A/ITGB7/COMP/HDAC1/PPP2R2D/SPP1/WNT7A/COL9A2/MAP2K2/PIK3R1/TNN/HRAS/RAF1/HES2/PPP2R5B/ISG15/COL6A6/EGFR/EIF4EBP1/WNT9B/CASP3/ATP6V1H/TSC1/HES4/CREB3L3/KRAS/PTGER4/COL6A1/MFNG/MDM2/TUBG1/TICAM1/MPP5/WNT5A/DVL1/PTGS2/ATM/CREB3/PPP2CB/RHEB/HES3/PARD6A/WNT2B/PPP2R5D/MAP2K1/AXIN1/CSNK1A1/EGF/CRB3/ITGA4/PRKCZ/ITGB1/STAT1/FOXO1/RPS6KB1/THBS2/CDK2/EIF2AK2/LAMA2/COL4A3/LAMA1/CCND3/COL2A1/LAMC3/RELA/LLGL1/ATP6V1E1/ATP6V0E1/FZD4/CTNNB1/ATP6V1D/ITGA2B/PRKACB/PIK3R3/PPP2R1A/IRF1/ATP6V1F/GNAS/TCF7L2/WNT9A/COL9A3/MAML2/IFNA4/APC/IFNA14/NOTCH2/CREBBP/WNT7B/SOS2/TBK1/WNT1/PIK3CB/TCIRG1/PXN/TBPL1/HDAC2/PPP2R3A/RFNG/WNT4/WNT16/ITGA3/COL6A3/CCNE1/DVL3/ITGB5/ITGAV/FN1/NFX1/PRKCI/TRAF3/MTOR/RBL2/PPP2R3C/PPP2CA/PDGFRB/ITGA7/IFNAR2/MX2/CHAD/IRF3/CDKN1B/LAMB2/ITGA10/RB1/SCRIB/SOS1/CREB1/FZD5/VWF/PSEN1	230
KEGG	hsa05340	Primary immunodeficiency	31/5183	38/8144	0.01332	0.06139	0.04624	CD3D/IL7R/LCK/CD3E/TNFRSF13B/RAG1/TAP1/ZAP70/PTPRC/AIRE/CD8B/AICDA/CD19/TAP2/IGLL1/UNG/CD4/ICOS/ORAI1/CD40/CIITA/ADA/CD79A/RFXAP/CD8A/CD40LG/DCLRE1C/TNFRSF13C/RFXANK/IL2RG/RAG2	31
KEGG	hsa04924	Renin secretion	53/5183	69/8144	0.01342	0.06139	0.04624	CALML3/KCNMA1/CALML6/ITPR1/CALML4/ADCYAP1R1/CALML5/ACE/GNAI3/PRKACA/ADCYAP1/CLCA1/ADCY5/PDE1A/EDN3/PDE3B/PRKG2/ORAI1/ITPR2/CLCA4/CACNA1S/PTGER2/ADCY6/CALM1/PTGER4/PDE1B/CTSB/PLCB1/NPR1/CALM2/GNAQ/EDN2/PPP3R1/PPP3CA/GNAI1/PLCB4/EDN1/AGTR1/PLCB2/PPP3CC/PPP3CB/PRKACB/GNAS/PLCB3/PPP3R2/CALM3/GUCY1A2/ADRB2/KCNJ2/CLCA2/ADRB3/CREB1/ADRB1	53
KEGG	hsa04371	Apelin signaling pathway	101/5183	139/8144	0.0148	0.06679	0.05031	RPS6KB2/GNGT2/PRKAA1/CALML3/PRKAG1/GNB3/CALML6/KLF2/ITPR1/CALML4/MAPK3/GNA13/SMAD2/MYL4/CALML5/GNG11/UCP1/GNAI3/ADCY4/HDAC5/PRKACA/SLC8A1/MYLK/ADCY5/PRKAA2/RYR1/PRKAG3/AKT2/PDE3B/RPS6/MEF2D/ITPR2/NRAS/ADCY3/MAPK1/GNGT1/CDH1/PIK3R5/SPP1/GNG4/RRAS/MAP2K2/HRAS/RAF1/ADCY6/SLC9A1/MAP1LC3B/MYL2/CALM1/ADCY2/KRAS/ADCY8/GNB4/PLCB1/SERPINE1/CALM2/GNAQ/GNG2/MAP1LC3A/MAP2K1/MEF2B/PIK3R6/GNAI1/ADCY7/RYR2/GNG7/RPS6KB1/PLCB4/GNG8/MEF2C/NRF1/APLNR/PIK3CG/AGTR1/PLCB2/NOS2/PRKACB/EGR1/PLCB3/SLC8A3/TGFBR1/PRKAG2/SMAD4/GNG3/PLIN1/SLC8A2/GNB1/LIPE/GNG5/SMAD3/MTOR/ADCY1/CALM3/PLAT/ACTA2/GNG10/MYL3/NOS1/PRKCE/MAP1LC3B2/CAMK4	101
KEGG	hsa04512	ECM-receptor interaction	66/5183	88/8144	0.01537	0.06742	0.05079	LAMA3/FRAS1/ITGA5/DSPP/GP9/TNXB/IBSP/VTN/LAMA5/LAMB4/THBS3/THBS4/TNC/CD36/ITGB6/ITGA6/ITGB3/ITGB4/HSPG2/DMP1/COL1A1/CD44/GP5/COL6A2/LAMA4/NPNT/GP1BA/AGRN/COL4A2/ITGA1/ITGA11/COL4A4/ITGB7/COMP/SPP1/FREM1/COL9A2/TNN/COL6A6/SV2B/COL6A1/FREM2/ITGA4/ITGB1/THBS2/LAMA2/COL4A3/LAMA1/COL2A1/SDC1/LAMC3/ITGA2B/COL9A3/SDC4/ITGA3/COL6A3/ITGB5/ITGAV/FN1/ITGA7/CHAD/CD47/LAMB2/ITGA10/GP1BB/VWF	66
KEGG	hsa05321	Inflammatory bowel disease	50/5183	65/8144	0.01541	0.06742	0.05079	TLR4/IL1B/IL10/RORA/TNF/IFNG/IL18/IFNGR2/IL21/IL12RB2/TLR5/IL23R/IL5/IL2/HLA-DMB/IL13/SMAD2/IL17A/IL23A/RORC/NOD2/STAT3/IL21R/NFKB1/IL4/HLA-DOA/IL22/NFATC1/IL12B/IL4R/TBX21/HLA-DQA1/HLA-DRA/IL17F/STAT6/TGFB2/FOXP3/IL12RB1/HLA-DQA2/TLR2/STAT1/HLA-DPB1/IL18R1/RELA/HLA-DOB/HLA-DMA/IL18RAP/MAF/SMAD3/IL2RG	50
KEGG	hsa04625	C-type lectin receptor signaling pathway	77/5183	104/8144	0.01554	0.06742	0.05079	FCER1G/PIK3CD/IL1B/IL10/TNF/IKBKE/PYCARD/EGR3/CALML3/PLK3/CLEC4M/CLEC4D/NLRP3/NFATC2/CALML6/ITPR1/CALML4/SYK/MAPK3/PRKCD/IL2/CALML5/IL23A/NFKBIA/PAK1/NFKB1/LSP1/CASP1/NFATC1/IL12B/CYLD/BCL10/MAPK10/AKT2/CASP8/MAPK12/PIK3R2/MAP3K14/ITPR2/NRAS/MAPK1/IRF9/MAPK9/RRAS/PIK3R1/HRAS/RAF1/CALM1/KRAS/CD209/MALT1/MDM2/PTGS2/MAPKAPK2/CALM2/ARHGEF12/PPP3R1/KSR1/PPP3CA/STAT1/CBLB/CCL17/RELA/PPP3CC/PPP3CB/PIK3R3/IRF1/PLCG2/MAPK14/NFKB2/CLEC7A/PIK3CB/BCL3/PPP3R2/CALM3/RELB/NFATC3	77
KEGG	hsa00830	Retinol metabolism	52/5183	68/8144	0.01648	0.07057	0.05315	DHRS9/CYP2B6/DGAT1/CYP3A4/CYP2C9/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/CYP2S1/UGT1A4/CYP3A5/UGT1A3/RDH12/RDH16/RPE65/UGT2B7/ALDH1A3/ADH6/CYP2C18/AOX1/LRAT/UGT1A1/ADH7/UGT2B11/CYP2A7/CYP27C1/ADH1C/CYP26B1/UGT2A3/CYP26C1/UGT2B10/CYP2W1/ADH1B/CYP3A7/RDH8/CYP26A1/RETSAT/DHRS4L2/UGT2B15/ADH5/RDH13/AWAT2/ALDH1A1/CYP1A1/RDH5/UGT2A1/ADH4/CYP2C8	52
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	95/5183	131/8144	0.01927	0.08147	0.06136	FASLG/CD247/PRF1/LCK/GZMB/ITGAL/FCER1G/TYROBP/PIK3CD/KLRD1/TNF/HLA-E/ICAM2/NCR3/IFNG/IFNGR2/KIR3DL2/SHC1/SH2D1A/CD244/PTPN6/ZAP70/NFATC2/SYK/MAPK3/KIR3DL1/KIR2DL1/KLRC1/FYN/IFNA7/TNFSF10/PAK1/GRB2/KIR2DL3/MICB/SHC2/IFNA8/NFATC1/KIR2DS4/RAC1/SHC4/RAET1E/HLA-B/PIK3R2/ITGB2/CSF2/FCGR3B/NRAS/PLCG1/MAPK1/ICAM1/SH2D1B/MAP2K2/PIK3R1/FCGR3A/HRAS/RAF1/TNFRSF10A/CASP3/PTK2B/KRAS/KIR3DL3/KLRC3/VAV2/LAT/PPP3R1/MAP2K1/KLRK1/PPP3CA/LCP2/RAC2/CD48/ULBP1/PPP3CC/PPP3CB/PIK3R3/HCST/IFNA4/IFNA14/PLCG2/SOS2/PIK3CB/RAC3/VAV1/PPP3R2/IFNAR2/BRAF/SH3BP2/PRKCB/BID/MICA/NCR1/TNFRSF10B/SOS1/NCR2	95
KEGG	hsa00591	Linoleic acid metabolism	24/5183	29/8144	0.02137	0.08812	0.06637	CYP3A4/CYP2C9/CYP1A2/PLA2G2D/PLA2G4A/PLA2G2F/PLA2G1B/PLB1/PLA2G4E/PLA2G4D/PLA2G2E/CYP2C19/PLA2G2C/PLA2G2A/PLA2G4C/PLA2G10/PLA2G5/PLA2G6/PLA2G12A/PLA2G3/PLA2G12B/CYP2J2/PLA2G4F/CYP2C8	24
KEGG	hsa04744	Phototransduction	24/5183	29/8144	0.02137	0.08812	0.06637	CALML3/CALML6/CALML4/CALML5/RHO/SLC24A1/PDE6B/CNGA1/CNGB1/GUCY2D/GNGT1/GRK1/CALM1/GUCA1B/PDE6G/GUCA1C/CALM2/GRK7/GNAT2/GUCA1A/RCVRN/GNAT1/GNB1/CALM3	24
KEGG	hsa04022	cGMP-PKG signaling pathway	119/5183	167/8144	0.02217	0.0903	0.06802	VDAC2/PLN/CALML3/ATP1A2/MYH6/GTF2IRD1/CREB3L2/NFATC2/KCNMA1/CALML6/MYH7/GNA12/FXYD2/ITPR1/CALML4/KCNMB2/MAPK3/GNA13/ATP2B2/NPR2/CREB3L4/CALML5/MYL9/ATP1A1/SLC25A31/GNAI3/ADCY4/INS/SLC8A1/MYLK/ADCY5/KNG1/ADRA1D/CNGA1/CREB5/ATP2A1/NFATC1/CNGB1/AKT2/ATP1B1/ADRA2A/PDE3B/PRKG2/MEF2D/ITPR2/GTF2I/ADCY3/MAPK1/CACNA1S/PIK3R5/MAP2K2/RAF1/ATF2/ADCY6/ATP2B3/ATP1A4/EDNRB/KCNU1/CALM1/PDE2A/ADCY2/IRS2/TRPC6/CREB3L3/KCNJ8/ADCY8/PLCB1/NPR1/NPPC/CALM2/CREB3/IRS1/GNAQ/ADRA2C/PPP3R1/MAP2K1/MEF2B/PPP3CA/PIK3R6/GNAI1/ADCY7/PLCB4/KCNMB4/INSR/MEF2C/PIK3CG/AGTR1/PLCB2/ADRA1B/PPP3CC/GATA4/PRKG1/KCNMB1/BDKRB2/ADORA3/KCNMB3/PPP3CB/PLCB3/ATP2B4/SLC8A3/SLC8A2/ADRA1A/ROCK1/ADRA2B/PPP3R2/PDE5A/ROCK2/ADCY1/CALM3/ATP1B2/GUCY1A2/ADRB2/ATP1A3/ADRB3/PRKCE/NFATC3/ATF4/CREB1/ADRB1	119
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	59/5183	79/8144	0.02444	0.09752	0.07345	RPS6KB2/PIK3CD/SHC1/JAK1/IL6R/MAPK3/BCL2L1/KDR/PDGFA/FGFR3/HGF/STAT3/ERBB2/GRB2/PTEN/FOXO3/SHC2/TGFA/GAB1/SHC4/MET/AKT2/PIK3R2/RPS6/NRAS/PLCG1/MAPK1/EIF4E1B/MAP2K2/PDGFB/PIK3R1/HRAS/RAF1/EGFR/EIF4EBP1/KRAS/PDGFC/NF1/PDGFD/ERBB3/MAP2K1/EGF/BCL2/RPS6KB1/IGF1R/FGFR2/BCL2L11/PIK3R3/PLCG2/FGF2/SOS2/PIK3CB/PDGFRA/MTOR/EIF4E2/PDGFRB/BRAF/PRKCB/SOS1	59
KEGG	hsa04921	Oxytocin signaling pathway	110/5183	154/8144	0.02453	0.09752	0.07345	PRKAA1/CALML3/ACTB/PRKAG1/NFATC2/CALML6/ITPR1/CALML4/MAPK3/CACNG1/NPR2/PLA2G4A/CACNA2D3/CACNG5/CALML5/MYL9/CDKN1A/EEF2/CAMK2A/GNAO1/GNAI3/ADCY4/KCNJ5/PRKACA/CAMK2B/MYLK/ADCY5/PLA2G4E/CAMK2G/PRKAA2/CACNG8/PLA2G4D/RYR1/NFATC1/CAMKK2/PRKAG3/CACNA2D1/TRPM2/ITPR2/NRAS/OXT/ADCY3/MAPK1/PLA2G4C/CACNA1S/PIK3R5/CD38/MAP2K2/HRAS/RAF1/ADCY6/EGFR/CALM1/ADCY2/KRAS/ADCY8/CACNG4/KCNJ12/PLCB1/OXTR/PTGS2/NPR1/KCNJ14/CALM2/GNAQ/PPP3R1/MAP2K1/KCNJ3/PPP3CA/PIK3R6/MYL6/GNAI1/ADCY7/RYR2/PLCB4/MEF2C/PIK3CG/PLCB2/PPP3CC/PPP3CB/PRKACB/GNAS/CACNB1/PLCB3/KCNJ4/RCAN1/PRKAG2/MAPK7/PPP1R12B/PLA2G4F/CACNG6/ROCK1/CACNA2D2/CACNB4/PPP3R2/FOS/ROCK2/ADCY1/CALM3/CACNG2/GUCY1A2/KCNJ2/PRKCB/CAMK1G/KCNJ6/NFATC3/CAMK4/CACNG7/MAP2K5/ACTG1	110
KEGG	hsa05223	Non-small cell lung cancer	54/5183	72/8144	0.02704	0.1063	0.08005	RASSF5/PIK3CD/E2F1/STAT5A/MAPK3/RXRA/GADD45G/HGF/STAT3/RARB/CDKN1A/ERBB2/GRB2/TP53/FOXO3/CDKN2A/FHIT/TGFA/MET/AKT2/RXRG/PIK3R2/CDK6/ALK/NRAS/PLCG1/MAPK1/STK4/MAP2K2/KIF5B/PIK3R1/HRAS/RAF1/EGFR/KRAS/CASP9/E2F3/MAP2K1/EGF/KIF5C/PIK3R3/GADD45A/PLCG2/SOS2/E2F2/PIK3CB/RET/STAT5B/POLK/BRAF/RXRB/PRKCB/RB1/SOS1	54
KEGG	hsa04071	Sphingolipid signaling pathway	86/5183	119/8144	0.02866	0.1113	0.08383	FCER1G/PIK3CD/S1PR1/TNF/SGMS1/ABCC1/GNA12/MAPK3/SGPL1/GNA13/FYN/TNFRSF1A/PPP2R5C/PPP2R2C/SGMS2/GNAI3/TP53/NFKB1/PTEN/SPTLC1/KNG1/FCER1A/PPP2R5A/MS4A2/MAPK10/RAC1/PPP2R5E/AKT2/MAPK12/PIK3R2/NSMAF/PLD1/NRAS/SPTLC2/S1PR3/MAP3K5/ACER1/MAPK1/PPP2R2A/MAPK9/PPP2R2D/SPTLC3/MAP2K2/PIK3R1/HRAS/RAF1/S1PR2/PPP2R5B/KRAS/PLCB1/PPP2CB/GNAQ/PLD2/PPP2R5D/MAP2K1/BCL2/GNAI1/PRKCZ/PLCB4/CTSD/RAC2/RELA/PLCB2/BDKRB2/ADORA3/PIK3R3/PPP2R1A/DEGS2/ASAH2/PLCB3/SMPD1/MAPK14/PIK3CB/SGPP1/RAC3/PPP2R3A/ROCK1/DEGS1/ROCK2/PPP2R3C/PPP2CA/PRKCB/PRKCE/BID/GAB2/SMPD2	86
KEGG	hsa04310	Wnt signaling pathway	118/5183	167/8144	0.03268	0.1254	0.09449	TCF7/CSNK1E/ROR1/CTNNBIP1/MMP7/NFATC2/LRP6/FRAT1/WNT8A/LEF1/FZD6/FZD10/SOX17/SFRP2/CCND2/NKD2/TBL1XR1/SFRP4/FRAT2/NKD1/CAMK2A/WNT2/WNT11/TP53/PRKACA/CAMK2B/VANGL1/TCF7L1/CAMK2G/FZD8/CSNK1A1L/WNT10A/NFATC1/RSPO2/CTBP2/BTRC/SOST/DKK1/FZD2/AXIN2/MAPK10/RAC1/DAAM1/SERPINF1/RSPO4/NOTUM/EP300/DAAM2/RUVBL1/PRICKLE2/CTBP1/FBXW11/WIF1/WNT3A/MAPK9/WNT7A/RSPO1/RSPO3/SENP2/DKK2/WNT9B/RNF43/PLCB1/WNT5A/DKK4/DVL1/CSNK2A1/FRZB/WNT2B/PPP3R1/AXIN1/NLK/PPP3CA/CSNK1A1/CSNK2B/PLCB4/CSNK2A2/RAC2/SIAH1/CACYBP/CCND3/CHD8/PLCB2/FZD4/CTNNB1/PPP3CC/TBL1Y/PPP3CB/PRKACB/TCF7L2/PLCB3/WNT9A/TLE3/SFRP1/APC/SMAD4/ZNRF3/VANGL2/TLE1/CREBBP/WNT7B/WNT1/RAC3/CER1/WNT4/WNT16/DVL3/LGR4/PPP3R2/SMAD3/ROCK2/ROR2/PRKCB/NFATC3/PRICKLE4/FZD5/LRP5/PSEN1	118
KEGG	hsa04390	Hippo signaling pathway	111/5183	157/8144	0.03661	0.139	0.1047	TCF7/CSNK1E/YWHAG/AREG/ACTB/FGF1/PARD6B/FRMD6/GLI2/WNT8A/SMAD2/LEF1/FZD6/DLG2/FZD10/CCND2/NKD2/WWC1/PARD3/AFP/PPP2R2C/NKD1/DLG1/TGFBR2/WNT2/WNT11/CTNNA3/STK3/YWHAZ/LIMD1/FRMD1/TCF7L1/BMP2/CRB1/BMPR1B/FZD8/WNT10A/TP53BP2/BIRC2/BTRC/FZD2/AXIN2/GDF6/TEAD1/CTNNA1/TEAD2/ITGB2/CRB2/FBXW11/PPP2R2A/CDH1/AMH/WNT3A/PPP2R2D/WNT7A/WNT9B/BMP7/BMP5/SOX2/BMP4/TP73/TGFB2/MPP5/WNT5A/DVL1/SERPINE1/BIRC3/PPP2CB/BMPR1A/PARD6A/WNT2B/AXIN1/RASSF6/GDF5/PRKCZ/CCND3/CTNNA2/LLGL1/SMAD1/FZD4/CTNNB1/ID1/PPP2R1A/SMAD7/TCF7L2/WNT9A/ID2/SAV1/TGFBR1/APC/SMAD4/TEAD3/DLG4/SNAI2/WNT7B/LATS2/WNT1/BBC3/WNT4/WNT16/DVL3/BMP6/PRKCI/LATS1/SMAD3/PPP2CA/AMOT/SCRIB/DLG5/FZD5/ACTG1	111
KEGG	hsa05202	Transcriptional misregulation in cancer	135/5183	193/8144	0.03724	0.1394	0.105	IL2RB/CEBPE/PTCRA/MPO/GZMB/LYL1/ELANE/SPI1/MEIS1/NR4A3/CEBPA/CDK14/HHEX/HOXA9/TRAF1/DEFA4/BCL11B/AFF1/LMO2/ERG/ETV6/MITF/RUNX2/RUNX1T1/DUSP6/BCL2L1/HOXA10/PDGFA/FCGR1A/PPARG/BCL2A1/TLX3/RXRA/PROM1/GADD45G/CCND2/MMP9/FLT3/RARA/CDKN1A/TGFBR2/MYCN/MLLT3/PAX3/TMPRSS2/SPINT1/TP53/PTK2/NFKB1/ITGAM/BMI1/NGFR/KLF3/SP1/SIX1/ZEB1/ETV5/TLX1/DEFA6/BIRC2/NFKBIZ/CCNA1/PBX3/MET/RXRG/FUT8/MMP3/CSF2/PLAU/DDIT3/IGFBP3/FLI1/LDB1/SIX4/ARNT2/HOXA11/CD40/PBX1/IL1R2/ITGB7/HDAC1/ZBTB17/IL3/NUPR1/MDM2/RUNX1/PRCC/ATM/BIRC3/MLLT1/DDX5/HMGA2/REL/MLF1/SUPT3H/FOXO1/TCF3/MEF2C/IGF1R/PAX5/ETV1/CD14/FEV/RELA/PAX7/SMAD1/ETV7/CDKN2C/DEFA5/JMJD1C/CCNT1/SLC45A3/MEN1/NCOR1/ID2/GADD45A/FUS/BAIAP3/SIN3A/HDAC2/ASPSCR1/SS18L1/WNT16/SS18/WT1/MAF/DEFA1/DEFA1B/POLK/PLAT/RXRB/CDKN1B/ETV4/CSF1R/EWSR1	135
KEGG	hsa05221	Acute myeloid leukemia	50/5183	67/8144	0.03756	0.1394	0.105	CEBPE/MPO/RPS6KB2/PIK3CD/TCF7/SPI1/CEBPA/RUNX1T1/STAT5A/DUSP6/MAPK3/FCGR1A/LEF1/BCL2A1/FLT3/RARA/STAT3/GRB2/NFKB1/ITGAM/TCF7L1/CCNA1/AKT2/PIK3R2/CSF2/NRAS/MAPK1/MAP2K2/PIK3R1/HRAS/RAF1/PIM1/EIF4EBP1/IL3/KRAS/RUNX1/KIT/MAP2K1/RPS6KB1/CD14/RELA/PIK3R3/TCF7L2/SOS2/PIK3CB/STAT5B/MTOR/BRAF/CSF1R/SOS1	50
KEGG	hsa04730	Long-term depression	45/5183	60/8144	0.04175	0.1532	0.1154	GNA12/ITPR1/MAPK3/GNA13/PLA2G4A/GRIA1/GNAO1/GNAI3/GRIA2/CACNA1A/PLA2G4E/PLA2G4D/RYR1/PRKG2/ITPR2/NRAS/MAPK1/PLA2G4C/LYN/GNAZ/MAP2K2/GRM1/HRAS/RAF1/CRHR1/KRAS/PLCB1/PPP2CB/GNAQ/MAP2K1/GNAI1/PLCB4/IGF1R/PLCB2/PRKG1/PPP2R1A/GNAS/PLCB3/PLA2G4F/PPP2CA/GUCY1A2/BRAF/PRKCB/NOS1/GRID2	45
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	40/5183	53/8144	0.04627	0.1678	0.1264	ATP1A2/FXYD2/KLK2/ATP2B2/CALB1/ATP1A1/TRPV5/DNM1/PRKACA/SLC8A1/ATP1B1/CLTA/ESR1/KL/DNM3/KLK1/ADCY6/ATP2B3/ATP1A4/CLTC/PLCB1/AP2M1/GNAQ/PLCB4/AP2A2/PLCB2/BDKRB2/PRKACB/GNAS/PLCB3/ATP2B4/SLC8A3/SLC8A2/AP2S1/ATP1B2/PTH1R/RAB11A/DNM2/ATP1A3/PRKCB	40
KEGG	hsa04145	Phagosome	107/5183	152/8144	0.04673	0.1678	0.1264	TLR4/MPO/CALR/OLR1/MARCO/CORO1A/FCAR/HLA-E/TLR6/EEA1/CTSS/SFTPD/FCGR2A/ATP6V0E2/DYNC1LI2/ITGA5/TAP1/CLEC4M/ACTB/HLA-DMB/RILP/CANX/THBS3/FCGR1A/RAB5C/ATP6V0A1/THBS4/HGS/HLA-F/STX18/TAP2/NCF4/CD36/MBL2/PIKFYVE/NCF2/ATP6V0D2/ITGB3/ITGAM/HLA-DOA/TUBB/LAMP1/ATP6V0A4/RAC1/SFTPA2/SEC61A1/ATP6V1B1/HLA-B/ATP6V1B2/MSR1/TUBA3C/ITGB2/FCGR3B/HLA-DQA1/ATP6V1C1/HLA-DRA/ATP6V1G3/ATP6V0D1/COMP/TUBA3E/PLA2R1/FCGR3A/TUBA4A/SEC61A2/TUBA1A/ATP6V1H/TUBB3/CD209/TUBA3D/VAMP3/HLA-DQA2/CYBA/ITGB1/TLR2/THBS2/TUBB8/COLEC11/TUBA8/NCF1/C1R/CD14/DYNC1I1/TUBB2A/HLA-DPB1/HLA-DOB/TUBA1B/ATP6V1E1/SEC61B/ATP6V0E1/ATP6V1D/HLA-DMA/SFTPA1/DYNC2H1/C3/ATP6V1F/CLEC7A/TCIRG1/ITGB5/ITGAV/DYNC1H1/DYNC1I2/MRC1/NOS1/SCARB1/STX7/TUBA1C/ACTG1	107
KEGG	hsa04923	Regulation of lipolysis in adipocytes	42/5183	56/8144	0.04838	0.1712	0.129	PNPLA2/PIK3CD/PTGS1/ABHD5/GNAI3/ADCY4/PRKACA/INS/ADCY5/AKT2/PIK3R2/PDE3B/PRKG2/ADCY3/NPY1R/PIK3R1/ADCY6/FABP4/ADCY2/IRS2/AQP7/ADCY8/PTGS2/NPR1/IRS1/GNAI1/ADCY7/CGA/INSR/PRKG1/PRKACB/PIK3R3/GNAS/PLIN1/PIK3CB/TSHB/LIPE/ADCY1/ADRB2/ADRB3/NPY/ADRB1	42
KEGG	hsa04950	Maturity onset diabetes of the young	21/5183	26/8144	0.0487	0.1712	0.129	HHEX/GCK/NKX6-1/HNF4A/RFX6/FOXA2/PDX1/PAX6/INS/PAX4/NKX2-2/ONECUT1/NEUROG3/IAPP/HNF4G/NEUROD1/MNX1/HES1/MAFA/BHLHA15/HNF1A	21
KEGG	hsa04726	Serotonergic synapse	82/5183	115/8144	0.05054	0.1758	0.1324	RAPGEF3/GNGT2/HTR3A/DDC/PTGS1/SLC18A1/CYP2C9/GNB3/ITPR1/HTR1B/MAPK3/PLA2G4A/TPH2/HTR3B/GNG11/GNAO1/GNAI3/SLC18A2/KCNJ5/HTR1F/TPH1/HTR1A/PRKACA/CACNA1A/CYP4X1/ADCY5/PLA2G4E/PLA2G4D/CYP2C18/HTR1D/ALOX12/HTR3C/ITPR2/NRAS/CYP2C19/HTR1E/MAPK1/PLA2G4C/GNGT1/HTR2A/HTR3E/CACNA1S/GNG4/HTR2B/HRAS/RAF1/CASP3/KRAS/APP/GNB4/PLCB1/HTR3D/ALOX12B/PTGS2/GNAQ/GNG2/MAP2K1/KCNJ3/CACNA1B/KCNN2/GNAI1/GNG7/PLCB4/GNG8/PLCB2/CYP2J2/PRKACB/GNAS/PLCB3/ALOX15B/GABRB2/GNG3/PLA2G4F/GNB1/GNG5/BRAF/GNG10/PRKCB/HTR7/KCNJ6/CYP2C8/HTR5A	82
KEGG	hsa00350	Tyrosine metabolism	28/5183	36/8144	0.05191	0.1769	0.1333	DDC/ALDH3B1/ALDH3B2/TYRP1/AOC3/TH/AOC2/FAH/HPD/GOT1L1/HGD/TYR/DCT/ADH6/AOX1/ADH7/TPO/ADH1C/TAT/FAHD1/COMT/ADH1B/LRTOMT/PNMT/DBH/GOT1/ADH5/ADH4	28
KEGG	hsa00500	Starch and sucrose metabolism	28/5183	36/8144	0.05191	0.1769	0.1333	G6PC3/TREH/GCK/GBA3/PGM1/PYGL/PYGM/GBE1/GYS2/ENPP3/GANC/HKDC1/MGAM/G6PC/GPI/HK3/UGP2/AMY2B/HK1/PYGB/GYG1/GAA/ENPP1/AGL/AMY2A/PGM2/PGM2L1/GYS1	28
KEGG	hsa05030	Cocaine addiction	37/5183	49/8144	0.05372	0.1812	0.1365	DDC/SLC18A1/CREB3L2/CREB3L4/TH/GNAI3/SLC18A2/NFKB1/PRKACA/GRIN3A/GRIA2/ADCY5/CREB5/CDK5R1/PPP1R1B/SLC6A3/ATF2/GRIN2B/PDYN/CREB3L3/GRIN2C/BDNF/CREB3/GNAI1/GRM3/GRIN3B/GRIN2A/RELA/PRKACB/DRD1/GNAS/DLG4/FOSB/CDK5/DRD2/ATF4/CREB1	37
KEGG	hsa05146	Amoebiasis	73/5183	102/8144	0.05621	0.1877	0.1414	LAMA3/TLR4/CD1C/SERPINB10/CTSG/PIK3CD/IL1B/IL10/TNF/IFNG/CD1B/CD1E/ARG1/SERPINB6/LAMA5/LAMB4/CXCL1/RAB5C/CXCL2/VCL/IL1R1/ARG2/MUC2/PTK2/NFKB1/PRKACA/GNA15/C9/ITGAM/COL1A1/C8B/SERPINB9/IL12B/SERPINB4/LAMA4/PIK3R2/ITGB2/CSF2/C8A/COL4A2/COL4A4/CXCL3/IL1R2/PIK3R1/CD1D/COL3A1/CASP3/TGFB2/PLCB1/CD1A/GNAQ/TLR2/PLCB4/LAMA2/COL4A3/LAMA1/CD14/C8G/LAMC3/RELA/PLCB2/NOS2/PRKACB/PIK3R3/GNAS/SERPINB3/PLCB3/PIK3CB/FN1/ADCY1/SERPINB13/PRKCB/LAMB2	73
KEGG	hsa04670	Leukocyte transendothelial migration	81/5183	114/8144	0.05783	0.1912	0.1441	CTNND1/TXK/ITK/RAPGEF3/RHOH/ITGAL/RASSF5/PIK3CD/CLDN15/MYL7/CLDN22/PECAM1/ACTB/CLDN18/CXCR4/CLDN16/CLDN1/MYL9/MMP9/CLDN19/VCL/CLDN14/CDC42/CLDN17/GNAI3/NCF4/CTNNA3/PTK2/NCF2/F11R/ITGAM/CLDN11/CLDN7/EZR/CDH5/RAPGEF4/RAC1/ESAM/MYL10/MAPK12/PIK3R2/CTNNA1/ITGB2/PLCG1/ICAM1/MYL5/PIK3R1/MYL2/BCAR1/PTK2B/CLDN25/MYLPF/RAP1B/VAV2/CLDN6/CYBA/ITGA4/GNAI1/ITGB1/CLDN9/NCF1/RAC2/CLDN3/CTNNA2/SIPA1/CTNNB1/PIK3R3/ARHGAP5/RAP1A/PLCG2/MAPK14/MMP2/MYL12A/PIK3CB/PXN/VAV1/ROCK1/CLDN20/ROCK2/PRKCB/ACTG1	81
KEGG	hsa00590	Arachidonic acid metabolism	45/5183	61/8144	0.06217	0.2002	0.1508	HPGDS/LTC4S/CYP2B6/PTGS1/CYP2C9/CYP4F2/GPX3/PLA2G2D/PLA2G4A/PLA2G2F/GPX6/PLA2G1B/PLB1/CYP4F8/PLA2G4E/PLA2G4D/CYP4F3/ALOX12/PLA2G2E/CYP2C19/PLA2G2C/PLA2G2A/PLA2G4C/PLA2G10/PLA2G5/PLA2G6/TBXAS1/PLA2G12A/ALOX12B/PTGS2/PLA2G3/GPX2/PLA2G12B/PTGES2/CYP2J2/GPX5/GPX1/GPX8/ALOX15B/PTGDS/PLA2G4F/PTGES3/GGT1/AKR1C3/CYP2C8	45
KEGG	hsa04211	Longevity regulating pathway	64/5183	89/8144	0.06235	0.2002	0.1508	RPS6KB2/PIK3CD/PRKAA1/PRKAG1/CREB3L2/APPL1/ADIPOR2/CREB3L4/PPARG/ADCY4/TP53/NFKB1/PRKACA/INS/FOXO3/ADCY5/PRKAA2/CREB5/CAMKK2/PRKAG3/AKT2/PIK3R2/RB1CC1/KL/NRAS/SESN2/ADCY3/TSC2/EIF4E1B/PIK3R1/ADIPOR1/HRAS/ATF2/ADCY6/EIF4EBP1/TSC1/ADCY2/IRS2/CREB3L3/KRAS/EHMT1/ADCY8/CREB3/IRS1/RHEB/EHMT2/ADCY7/FOXO1/RPS6KB1/INSR/IGF1R/STK11/RELA/ATG5/PRKACB/PIK3R3/PRKAG2/PIK3CB/MTOR/ADCY1/EIF4E2/ATF4/CREB1/CAMK4	64
KEGG	hsa00511	Other glycan degradation	15/5183	18/8144	0.06238	0.2002	0.1508	GLB1/NEU2/MAN2B2/GBA/NEU4/AGA/FUCA2/ENGASE/MANBA/MAN2B1/NEU1/HEXA/NEU3/HEXB/MAN2C1	15
KEGG	hsa00592	alpha-Linolenic acid metabolism	20/5183	25/8144	0.06326	0.2002	0.1508	PLA2G2D/PLA2G4A/PLA2G2F/FADS2/PLA2G1B/PLB1/PLA2G4E/PLA2G4D/PLA2G2E/PLA2G2C/PLA2G2A/PLA2G4C/ACOX3/PLA2G10/PLA2G5/PLA2G6/PLA2G12A/PLA2G3/PLA2G12B/PLA2G4F	20
KEGG	hsa01522	Endocrine resistance	70/5183	98/8144	0.06415	0.2002	0.1508	RPS6KB2/PIK3CD/SHC1/E2F1/HBEGF/MAPK3/JAG2/MMP9/CDKN1A/ERBB2/ADCY4/GRB2/TP53/PTK2/PRKACA/ADCY5/CDKN2A/SP1/SHC2/MAPK10/SHC4/AKT2/NOTCH4/MAPK12/PIK3R2/ESR1/NRAS/ADCY3/MAPK1/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/ADCY6/EGFR/ADCY2/KRAS/DLL3/ADCY8/MDM2/E2F3/MAP2K1/BCL2/CARM1/ADCY7/RPS6KB1/IGF1R/NCOA3/CDKN2C/PRKACB/PIK3R3/GNAS/NCOR1/DLL4/MAPK14/NOTCH2/MMP2/BIK/SOS2/E2F2/PIK3CB/ABCB11/FOS/MTOR/ADCY1/BRAF/CDKN1B/RB1/SOS1	70
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	70/5183	98/8144	0.06415	0.2002	0.1508	PIK3CD/IL1B/F2RL1/P2RY2/PRKCH/CALML3/CALML6/ITPR1/CALML4/PRKCD/PLA2G4A/CALML5/BDKRB1/TRPV1/TRPV3/IL1R1/CAMK2A/ADCY4/PRKACA/CAMK2B/ADCY5/PLA2G4E/KNG1/CAMK2G/PLA2G4D/MAPK10/ALOX12/MAPK12/PIK3R2/IL1RAP/ITPR2/TRPA1/ADCY3/PLCG1/PLA2G4C/HTR2A/MAPK9/PTGER2/HTR2B/PIK3R1/ADCY6/PLA2G6/CALM1/ADCY2/MAP2K6/PTGER4/ADCY8/PLCB1/TRPM8/CALM2/GNAQ/ADCY7/PLCB4/PLCB2/CYP2J2/BDKRB2/PRKACB/PIK3R3/GNAS/PLCB3/PLCG2/TRPV2/MAPK14/PIK3CB/MAP2K3/PLA2G4F/ADCY1/CALM3/PRKCB/PRKCE	70
KEGG	hsa04064	NF-kappa B signaling pathway	74/5183	104/8144	0.06504	0.2011	0.1515	LTA/TLR4/LCK/LTBR/IL1B/TNF/LTB/LBP/TRAF1/ZAP70/EDAR/TNFSF14/SYK/BCL2L1/CXCL1/TNFSF13B/BCL2A1/CXCL2/TNFRSF1A/CCL21/GADD45G/NFKBIA/IL1R1/TICAM2/RIPK1/NFKB1/CCL4/EDARADD/BIRC2/CYLD/BCL10/CCL13/IRAK4/PLAU/MAP3K14/CD40/PLCG1/TRAF6/TRAF5/ICAM1/CXCL3/LYN/CARD11/MALT1/CFLAR/TICAM1/LY96/CARD14/PTGS2/ATM/CSNK2A1/BIRC3/TNFAIP3/LAT/TIRAP/CCL19/CSNK2B/BCL2/CSNK2A2/EDA2R/TRIM25/CD14/RELA/PARP1/GADD45A/PLCG2/CD40LG/NFKB2/ERC1/TNFRSF13C/UBE2I/TRAF3/PRKCB/RELB	74
KEGG	hsa04917	Prolactin signaling pathway	51/5183	70/8144	0.0666	0.2041	0.1537	PIK3CD/CISH/SHC1/SOCS2/STAT5A/MAPK3/GCK/TH/CSN2/CCND2/STAT3/LHB/ELF5/GRB2/NFKB1/INS/FOXO3/SHC2/CYP17A1/MAPK10/SHC4/AKT2/MAPK12/PIK3R2/PRL/ESR1/NRAS/MAPK1/SOCS5/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/KRAS/GALT/SOCS7/MAP2K1/STAT1/CGA/RELA/SOCS1/PIK3R3/IRF1/LHCGR/MAPK14/SOS2/PIK3CB/STAT5B/FOS/SOS1	51
KEGG	hsa05212	Pancreatic cancer	55/5183	76/8144	0.06886	0.2072	0.1561	RPS6KB2/PIK3CD/E2F1/JAK1/MAPK3/BCL2L1/SMAD2/GADD45G/STAT3/CDC42/CDKN1A/ERBB2/TGFBR2/TP53/NFKB1/RALBP1/CDKN2A/TGFA/MAPK10/RAC1/AKT2/PIK3R2/CDK6/PLD1/MAPK1/MAPK9/PIK3R1/RAF1/EGFR/RALB/KRAS/CASP9/TGFB2/BRCA2/E2F3/PLD2/MAP2K1/EGF/STAT1/RPS6KB1/RAC2/RELA/PIK3R3/GADD45A/TGFBR1/SMAD4/E2F2/PIK3CB/RAC3/SMAD3/MTOR/POLK/BRAF/RB1/RALGDS	55
KEGG	hsa05220	Chronic myeloid leukemia	55/5183	76/8144	0.06886	0.2072	0.1561	PIK3CD/SHC1/E2F1/CBL/STAT5A/MAPK3/BCL2L1/BCR/GADD45G/NFKBIA/CDKN1A/TGFBR2/GRB2/TP53/NFKB1/CDKN2A/SHC2/CTBP2/SHC4/AKT2/PIK3R2/CDK6/NRAS/CTBP1/MAPK1/MECOM/HDAC1/MAP2K2/PIK3R1/HRAS/RAF1/KRAS/MDM2/TGFB2/RUNX1/E2F3/ABL1/MAP2K1/RELA/PIK3R3/GADD45A/TGFBR1/SMAD4/SOS2/E2F2/PIK3CB/HDAC2/STAT5B/SMAD3/POLK/BRAF/CDKN1B/RB1/GAB2/SOS1	55
KEGG	hsa04012	ErbB signaling pathway	61/5183	85/8144	0.07143	0.2088	0.1573	RPS6KB2/PIK3CD/AREG/SHC1/CBL/HBEGF/STAT5A/ABL2/MAPK3/CDKN1A/CAMK2A/ERBB2/PAK1/GRB2/PTK2/CAMK2B/NRG3/CAMK2G/SHC2/TGFA/GAB1/MAPK10/SHC4/AKT2/PIK3R2/NRAS/NRG4/PLCG1/MAPK1/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/EIF4EBP1/MAP2K4/KRAS/ABL1/ERBB3/MAP2K1/EGF/PAK4/RPS6KB1/CBLB/NCK2/PIK3R3/EREG/PLCG2/PAK2/SOS2/PIK3CB/BTC/STAT5B/MTOR/BRAF/NCK1/CDKN1B/PAK3/PRKCB/SOS1	61
KEGG	hsa05134	Legionellosis	42/5183	57/8144	0.07208	0.2088	0.1573	TLR4/IL1B/TNF/IL18/PYCARD/NLRC4/TLR5/NAIP/CXCL1/CXCL2/HSPA8/NFKBIA/NFKB1/CASP1/CR1/ITGAM/RAB1B/IL12B/RAB1A/CASP8/EEF1A1/ITGB2/CXCL3/SAR1A/ARF1/CASP3/CASP9/BCL2L13/CYCS/HSPA1A/VCP/HSPA2/HSPA1L/TLR2/CD14/EEF1A2/RELA/HBS1L/C3/CLK4/NFKB2/CR1L	42
KEGG	hsa00770	Pantothenate and CoA biosynthesis	17/5183	21/8144	0.07286	0.2088	0.1573	VNN1/PPCDC/ALDH2/ENPP3/UPB1/ALDH3A2/VNN2/AASDHPPT/PANK3/DPYD/PANK2/BCAT1/GADL1/ENPP1/COASY/PPCS/PANK1	17
KEGG	hsa05219	Bladder cancer	31/5183	41/8144	0.07288	0.2088	0.1573	E2F1/HBEGF/MAPK3/FGFR3/MMP9/CDKN1A/ERBB2/TP53/MMP1/RPS6KA5/UPK3A/CDKN2A/TYMP/NRAS/MAPK1/CDH1/DAPK3/MAP2K2/HRAS/RAF1/EGFR/DAPK2/KRAS/MDM2/E2F3/MAP2K1/EGF/MMP2/E2F2/BRAF/RB1	31
KEGG	hsa04657	IL-17 signaling pathway	67/5183	94/8144	0.07322	0.2088	0.1573	S100A8/S100A9/IL1B/S100A7/TNF/IFNG/IKBKE/IL17RC/IL25/CCL11/MAPK3/IL5/IL13/TRAF3IP2/LCN2/CXCL1/CXCL2/IL17A/CCL7/MMP9/MUC5B/NFKBIA/CXCL6/NFKB1/MMP1/IL4/USP25/IL17B/IL17RE/CCL20/FADD/CSF3/CXCL10/MAPK10/HSP90B1/CASP8/MAPK12/MMP3/CSF2/JUND/TRAF6/MAPK1/TRAF5/CXCL3/MAPK9/IL17F/CASP3/HSP90AA1/MMP13/PTGS2/MAPK6/TNFAIP3/CCL17/RELA/IL17C/IL17RB/MAPK14/MAPK7/TRAF4/TBK1/CCL2/HSP90AB1/FOSB/FOS/MAPK15/TRAF3/MAPK4	67
KEGG	hsa05416	Viral myocarditis	44/5183	60/8144	0.07387	0.2088	0.1573	PRF1/CD28/ITGAL/HLA-E/MYH6/ACTB/SGCA/MYH7/ABL2/HLA-DMB/FYN/EIF4G3/HLA-F/HLA-DOA/RAC1/CASP8/HLA-B/ITGB2/HLA-DQA1/CD40/HLA-DRA/ICAM1/SGCG/CASP3/CAV1/CASP9/CD55/CYCS/HLA-DQA2/ABL1/SGCD/SGCB/LAMA2/RAC2/EIF4G1/LAMA1/HLA-DPB1/HLA-DOB/HLA-DMA/CD80/CD40LG/RAC3/BID/ACTG1	44
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	71/5183	100/8144	0.07406	0.2088	0.1573	PIK3CD/IL1B/TNF/STAT5A/MAPK3/PRKCD/SMAD2/DIAPH1/STAT3/CDC42/TGFBR2/SELE/NFKB1/PLCE1/COL1A1/NFATC1/THBD/MAPK10/RAC1/NOX4/AKT2/MAPK12/PIK3R2/COL4A2/NRAS/COL4A4/PLCG1/MAPK1/ICAM1/MAPK9/PIK3R1/HRAS/PIM1/COL3A1/CASP3/KRAS/TGFB2/PLCB1/SERPINE1/PLCD3/BCL2/PRKCZ/STAT1/FOXO1/PLCB4/COL4A3/EDN1/RELA/AGTR1/PLCB2/F3/PIK3R3/EGR1/PLCD4/PLCB3/TGFBR1/SMAD4/PLCG2/MAPK14/MMP2/PLCD1/PIK3CB/CCL2/AGER/STAT5B/FN1/SMAD3/VEGFC/CDKN1B/PRKCB/PRKCE	71
KEGG	hsa04974	Protein digestion and absorption	73/5183	103/8144	0.07439	0.2088	0.1573	CPB2/KCNE3/CELA3A/ATP1A2/COL13A1/KCNK5/FXYD2/CELA2A/COL16A1/COL18A1/CTRB2/SLC36A4/COL27A1/COL11A2/MEP1A/CPA1/ATP1A1/SLC36A2/COL22A1/CPA3/PGA4/SLC6A19/SLC36A1/SLC8A1/COL1A1/ELN/COL5A1/SLC3A1/COL6A2/MME/CELA2B/ATP1B1/CTRL/SLC16A10/CTRB1/COL4A2/COL4A4/KCNJ13/COL8A1/COL9A2/COL25A1/SLC7A9/COL6A6/COL3A1/ATP1A4/CPB1/SLC9A3/COL6A1/SLC1A5/KCNQ1/ACE2/COL21A1/DPP4/PGA3/PRSS1/KCNN4/CELA3B/MEP1B/COL4A3/COL2A1/SLC15A1/COL20A1/PGA5/COL9A3/SLC36A3/COL15A1/SLC8A3/SLC7A8/SLC8A2/COL6A3/COL17A1/ATP1B2/ATP1A3	73
KEGG	hsa05310	Asthma	24/5183	31/8144	0.07587	0.2112	0.1591	FCER1G/IL10/RNASE3/TNF/CCL11/IL5/HLA-DMB/IL13/EPX/IL4/HLA-DOA/FCER1A/MS4A2/IL9/HLA-DQA1/CD40/HLA-DRA/IL3/HLA-DQA2/HLA-DPB1/HLA-DOB/HLA-DMA/CD40LG/PRG2	24
KEGG	hsa05031	Amphetamine addiction	50/5183	69/8144	0.07815	0.2139	0.1611	DDC/SLC18A1/CALML3/CREB3L2/STX1A/CALML6/CALML4/GRIA1/CREB3L4/CALML5/TH/GRIA4/CAMK2A/SLC18A2/PRKACA/GRIN3A/CAMK2B/GRIA2/ADCY5/CAMK2G/CREB5/PPP1R1B/HDAC1/SLC6A3/ATF2/GRIN2B/PDYN/CALM1/CREB3L3/GRIN2C/CALM2/CREB3/PPP3R1/PPP3CA/GRIN3B/GRIN2A/PPP3CC/PPP3CB/PRKACB/DRD1/GNAS/HDAC2/FOSB/PPP3R2/FOS/CALM3/PRKCB/ATF4/CREB1/CAMK4	50
KEGG	hsa05211	Renal cell carcinoma	50/5183	69/8144	0.07815	0.2139	0.1611	ETS1/PIK3CD/RAPGEF1/ARNT/MAPK3/EGLN1/HGF/CDC42/CDKN1A/CUL2/PAK1/GRB2/HIF1A/SLC2A1/EGLN3/TGFA/GAB1/RAC1/MET/AKT2/PIK3R2/EP300/NRAS/ARNT2/MAPK1/EGLN2/MAP2K2/PDGFB/PIK3R1/EPAS1/HRAS/RAF1/KRAS/TGFB2/PRCC/RAP1B/MAP2K1/PAK4/FLCN/PIK3R3/FH/RAP1A/PAK2/CREBBP/SOS2/PIK3CB/BRAF/VHL/PAK3/SOS1	50
KEGG	hsa00620	Pyruvate metabolism	35/5183	47/8144	0.07898	0.2145	0.1615	PCK2/ME3/ACSS1/PC/PCK1/ALDH2/ADH6/ACAT1/GRHPR/ADH7/ACSS2/MDH2/ACYP2/LDHAL6B/ADH1C/ALDH3A2/ME1/ACYP1/ADH1B/ALDH7A1/DLD/GLO1/HAGH/LDHA/PDHB/LDHB/ACACA/FH/ADH5/DLAT/ME2/ALDH9A1/LDHD/ADH4/LDHC	35
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	56/5183	78/8144	0.08111	0.216	0.1627	HPGDS/GSTT2B/CYP2B6/CYP3A4/ALDH3B1/CYP2C9/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/CYP2S1/UGT1A4/GSTA5/CYP3A5/UGT1A3/GSTP1/ALDH3B2/GSTA4/GSTT2/GSTM2/UGT2B7/ADH6/AKR1C1/UGT1A1/EPHX1/ADH7/UGT2B11/SULT2A1/CYP2A7/ADH1C/CYP2F1/AKR7A2/GSTA2/UGT2A3/GSTA1/CYP2A13/UGT2B10/ADH1B/MGST1/AKR7A3/AKR7L/MGST2/GSTM4/UGT2B15/ADH5/GSTK1/GSTT1/GSTM3/CYP1A1/HSD11B1L/UGT2A1/ADH4/CYP1B1	56
KEGG	hsa04721	Synaptic vesicle cycle	56/5183	78/8144	0.08111	0.216	0.1627	ATP6V0E2/SLC18A1/STX1A/UNC13C/SLC1A3/SLC18A3/ATP6V0A1/SLC6A11/RIMS1/SLC18A2/DNM1/SYT1/SLC6A9/RAB3A/ATP6V0D2/CACNA1A/SLC32A1/NAPA/SLC6A5/ATP6V0A4/ATP6V1B1/ATP6V1B2/CLTA/STXBP1/ATP6V1C1/DNM3/ATP6V1G3/ATP6V0D1/STX2/SLC1A7/SLC6A3/NSF/ATP6V1H/SLC1A6/CLTC/AP2M1/SNAP25/SLC17A6/CACNA1B/AP2A2/ATP6V1E1/ATP6V0E1/ATP6V1D/CPLX4/ATP6V1F/STX1B/SLC6A13/SLC1A2/SLC17A8/SLC6A1/TCIRG1/AP2S1/STX3/DNM2/CPLX1/SLC17A7	56
KEGG	hsa05144	Malaria	37/5183	50/8144	0.0815	0.216	0.1627	TLR4/ITGAL/IL1B/IL10/KLRB1/TNF/IFNG/IL18/GYPC/PECAM1/THBS3/CD81/THBS4/HGF/CD36/SELE/LRP1/CR1/GYPB/CSF3/MET/ITGB2/CD40/ICAM1/HBB/COMP/HBA1/TGFB2/KLRK1/TLR2/THBS2/TLR9/SDC1/SDC2/CD40LG/CCL2/CR1L	37
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	28/5183	37/8144	0.08522	0.2241	0.1688	PIK3CD/ATP1A2/FXYD4/FXYD2/MAPK3/ATP1A1/SGK1/KCNJ1/INS/SCNN1A/ATP1B1/PIK3R2/HSD11B2/MAPK1/PIK3R1/ATP1A4/NR3C2/KRAS/SFN/IRS1/NEDD4L/INSR/SCNN1G/PIK3R3/PIK3CB/ATP1B2/ATP1A3/PRKCB	28
KEGG	hsa05132	Salmonella infection	169/5183	249/8144	0.08893	0.2286	0.1722	TLR4/RHOH/PIK3CD/TCF7/IL1B/TNF/TLR6/RIPK2/IL18/PYCARD/MYL7/CYTH1/NCKAP1L/DYNC1LI2/NLRC4/DCTN2/ELMO1/ACTB/NLRP3/TLR5/PTPRC/CYFIP1/PIK3C2G/MAPK3/NOD1/FYCO1/RILP/NAIP/LEF1/KLC2/RAB5C/TNFRSF1A/MYL9/TNFSF10/NFKBIA/WASF3/CDC42/PAK1/RIPK1/NFKB1/CASP1/TCF7L1/AHNAK2/TUBB/VPS41/CASP5/FADD/S100A10/BIRC2/EXOC4/PIK3C2A/MAPK10/RAC1/RPS3/AKT2/MYL10/HSP90B1/CASP8/MAPK12/PKN1/CASP4/TUBA3C/IRAK4/CYTH4/SNX9/FBXO22/PLEKHM1/PFN2/DYNC2LI1/FHOD1/TRAF6/MAPK1/ABI1/MYL5/SNX18/MAPK9/TUBA3E/GSDMD/RRAS/MAP2K2/KIF5B/TUBA4A/HRAS/RAF1/ARF1/ARPC4/TNFRSF10A/NCKAP1/FLNC/ACTR1A/TUBA1A/MYL2/CASP3/HSP90AA1/STX10/CYFIP2/MAP2K4/MAP2K6/TUBB3/CYCS/ARF6/TUBA3D/GAPDH/LY96/MYLPF/DCTN6/DCTN3/BIRC3/TIRAP/MAP2K1/RHOG/PFN1/BCL2/PFN4/MLKL/TXN2/TLR2/DYNLL2/TLR9/TUBB8/PIK3C2B/TUBA8/CD14/DYNC1I1/KIF5C/TUBB2A/DCTN4/RELA/PIK3CG/TUBA1B/KLC4/PLEKHM2/CYTH3/CTNNB1/DYNLRB2/GCC2/KPNA4/DYNC2H1/TCF7L2/MAPK14/MYL12A/VPS18/ACTR3C/CYTH2/PIK3CB/MAP2K3/KLC1/SNX33/ACTR2/EXOC2/HSP90AB1/ARL8B/ELMO2/ARPC5L/FOS/ROCK2/DYNC1H1/ACTR3B/VPS11/DYNC1I2/DNM2/PAK3/ACTR10/TNFRSF10B/DYNLRB1/RAB9A/DCTN1/TUBA1C/ACTG1	169
KEGG	hsa00260	Glycine, serine and threonine metabolism	30/5183	40/8144	0.08896	0.2286	0.1722	PSAT1/AMT/GAMT/SARDH/AOC3/AOC2/ALAS1/GNMT/GCAT/DAO/GRHPR/AGXT2/SHMT1/PHGDH/ALDH7A1/DLD/SDSL/SDS/BPGM/CBS/PGAM4/GLDC/GLYCTK/PSPH/CHDH/SHMT2/SRR/GCSH/PGAM2/GATM	30
KEGG	hsa05033	Nicotine addiction	30/5183	40/8144	0.08896	0.2286	0.1722	CHRNA6/GRIA1/GABRR1/GRIA4/GRIN3A/GABRA2/GRIA2/CHRNB2/CACNA1A/SLC32A1/GABRA4/CHRNA4/GABRP/CHRNA7/GABRA1/GABRD/GABRA6/GRIN2B/GABRA5/GRIN2C/GABRG2/GABRR3/GABRA3/SLC17A6/CACNA1B/GRIN3B/GRIN2A/SLC17A8/GABRB2/SLC17A7	30
KEGG	hsa04910	Insulin signaling pathway	95/5183	137/8144	0.09409	0.2399	0.1807	RPS6KB2/PIK3CD/PRKAA1/FBP2/RAPGEF1/G6PC3/SHC1/SOCS2/CBL/CALML3/MKNK1/MKNK2/SORBS1/PRKAG1/PCK2/FBP1/CALML6/PPP1R3D/CALML4/MAPK3/CALML5/GCK/PRKAR1A/SREBF1/PTPRF/GRB2/PRKACA/INS/PCK1/PYGL/PHKB/PYGM/SHC2/PRKAA2/GYS2/INPP5A/MAPK10/PRKAG3/SHC4/AKT2/PIK3R2/PDE3B/RPS6/HKDC1/NRAS/MAPK1/TSC2/EIF4E1B/MAPK9/PPP1R3A/G6PC/MAP2K2/PIK3R1/HRAS/RAF1/FASN/EIF4EBP1/HK3/TSC1/CALM1/IRS2/KRAS/PRKAR2B/CALM2/IRS1/RHEB/TRIP10/MAP2K1/PPP1R3C/PRKCZ/FOXO1/RPS6KB1/CBLB/INSR/HK1/PYGB/SOCS1/ACACA/PRKACB/PIK3R3/PHKG1/INPPL1/RHOQ/PRKAG2/FLOT1/SOS2/PIK3CB/LIPE/PRKCI/GYS1/MTOR/CALM3/EIF4E2/BRAF/SOS1	95
KEGG	hsa04722	Neurotrophin signaling pathway	83/5183	119/8144	0.09582	0.2425	0.1826	FASLG/IRAK3/PIK3CD/RAPGEF1/RIPK2/SHC1/RPS6KA1/CALML3/CALML6/ARHGDIB/CALML4/MAPK3/PRKCD/SORT1/MAP3K3/CALML5/NFKBIA/CDC42/CAMK2A/GRB2/TP53/NFKB1/CAMK2B/RPS6KA5/FOXO3/NGFR/CAMK2G/SHC2/NTF3/GAB1/MAPK10/RAC1/SHC4/AKT2/MAPK12/PIK3R2/IRAK4/NRAS/MAP3K5/PLCG1/TRAF6/MAPK1/FRS2/MAPK9/MAP2K2/PIK3R1/ARHGDIG/HRAS/RAF1/CALM1/KRAS/NTRK3/TP73/BDNF/NFKBIB/PRDM4/MAPKAPK2/MAP3K1/RAP1B/CALM2/IRS1/ABL1/MAP2K1/BCL2/NFKBIE/NTRK2/RELA/PIK3R3/RPS6KA2/RAP1A/PLCG2/MAPK14/MAPK7/SOS2/PIK3CB/CALM3/BRAF/SOS1/ATF4/ZNF274/CAMK4/PSEN1/MAP2K5	83
KEGG	hsa00010	Glycolysis / Gluconeogenesis	48/5183	67/8144	0.1062	0.2668	0.2009	FBP2/G6PC3/PGK2/ALDH3B1/PCK2/FBP1/ALDH3B2/ALDOB/ACSS1/GCK/PGM1/MINPP1/PCK1/ALDH2/ALDOC/ADH6/ADH7/ENO1/ACSS2/HKDC1/LDHAL6B/ADH1C/ALDH3A2/TPI1/G6PC/GPI/HK3/ADH1B/ADPGK/GAPDH/ALDH7A1/DLD/ENO3/LDHA/PDHB/LDHB/HK1/GALM/BPGM/ADH5/PGAM4/DLAT/ALDH9A1/PGM2/ADH4/PGAM2/LDHC/GAPDHS	48
KEGG	hsa00562	Inositol phosphate metabolism	52/5183	73/8144	0.1077	0.2684	0.2022	PIK3CD/ITPKB/SYNJ1/PIK3C2G/INPP5D/PLCH2/INPP4A/MINPP1/INPP5K/IPMK/ITPKA/PIKFYVE/INPP5B/PTEN/PLCE1/IMPA1/MTMR3/MIOX/MTMR14/PLCZ1/IMPA2/INPP5A/PIK3C2A/MTMR7/PIP4K2A/PLCG1/PI4K2B/TPI1/IPPK/PLCB1/SYNJ2/PIP5KL1/PLCH1/PLCD3/ALDH6A1/ISYNA1/PIP4K2C/PLCB4/PIK3C2B/PIK3CG/PLCB2/PI4KB/PLCD4/PLCB3/INPPL1/PLCG2/PLCD1/PI4K2A/PIK3CB/PIP5K1B/INPP5J/PIP5K1A	52
KEGG	hsa04066	HIF-1 signaling pathway	76/5183	109/8144	0.1086	0.2686	0.2023	TLR4/LTBR/RPS6KB2/PIK3CD/IFNG/IFNGR2/PGK2/MKNK1/MKNK2/ARNT/IL6R/MAPK3/EGLN1/ALDOB/STAT3/CDKN1A/CAMK2A/ERBB2/CUL2/NFKB1/INS/CAMK2B/HIF1A/SLC2A1/CAMK2G/EGLN3/ALDOC/ANGPT4/AKT2/ENO1/PIK3R2/RPS6/HKDC1/EP300/HMOX1/EPO/LDHAL6B/PLCG1/MAPK1/EGLN2/EIF4E1B/MAP2K2/PIK3R1/EGFR/EIF4EBP1/HK3/GAPDH/ANGPT2/SERPINE1/PFKFB3/MAP2K1/EGF/BCL2/RPS6KB1/ENO3/INSR/IGF1R/LDHA/EDN1/RELA/PDHB/LDHB/HK1/NOS2/PIK3R3/TF/PLCG2/CREBBP/PIK3CB/TEK/MTOR/EIF4E2/VHL/CDKN1B/PRKCB/LDHC	76
KEGG	hsa04350	TGF-beta signaling pathway	66/5183	94/8144	0.1094	0.2686	0.2023	RPS6KB2/TNF/IFNG/ID3/MAPK3/RBL1/ACVR1/SMAD2/CDKN2B/THSD4/TGFBR2/TGIF2/PITX2/ID4/AMHR2/DCN/BMP2/NBL1/SP1/BMPR1B/SMAD6/LTBP1/SMAD5/GDF6/FBN1/EP300/SMURF1/MAPK1/AMH/CHRD/BMP7/BMP5/BMP4/TGFB2/INHBA/PPP2CB/BMPR1A/TFDP1/GDF5/RPS6KB1/ZFYVE16/SMAD1/FST/NEO1/ID1/PPP2R1A/GREM1/ACVR1B/INHBC/SMAD7/ID2/TGFBR1/SMAD4/HAMP/ZFYVE9/CREBBP/ROCK1/E2F4/NOG/BMP6/NODAL/SMAD3/ACVR1C/PPP2CA/SMAD9/INHBB	66
KEGG	hsa00430	Taurine and hypotaurine metabolism	13/5183	16/8144	0.1111	0.2709	0.204	FMO1/FMO3/GGT7/BAAT/ADO/GAD2/GGT6/GADL1/CDO1/FMO4/GAD1/GGT1/FMO2	13
KEGG	hsa05414	Dilated cardiomyopathy	67/5183	96/8144	0.1236	0.2978	0.2243	TNF/PLN/ITGA5/MYH6/ACTB/SGCA/MYH7/CACNG1/CACNA2D3/CACNG5/ADCY4/ITGB6/TNNT2/PRKACA/ITGA6/ITGB3/ITGB4/SLC8A1/ADCY5/ATP2A1/CACNG8/TNNC1/CACNA2D1/ITGA1/ITGA11/ADCY3/MYBPC3/CACNA1S/ITGB7/SGCG/ADCY6/MYL2/ADCY2/ADCY8/CACNG4/TGFB2/SGCD/TPM3/SGCB/ITGA4/ADCY7/RYR2/ITGB1/LAMA2/LAMA1/DES/ITGA2B/PRKACB/GNAS/CACNB1/SLC8A3/SLC8A2/CACNG6/CACNA2D2/ITGA3/CACNB4/ITGB5/ITGAV/ADCY1/CACNG2/ITGA7/ITGA10/MYL3/TPM4/ADRB1/CACNG7/ACTG1	67
KEGG	hsa00982	Drug metabolism - cytochrome P450	51/5183	72/8144	0.1239	0.2978	0.2243	HPGDS/GSTT2B/CYP2B6/CYP3A4/ALDH3B1/CYP2C9/UGT1A5/CYP1A2/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/FMO1/GSTA5/CYP3A5/UGT1A3/GSTP1/ALDH3B2/GSTA4/FMO3/GSTT2/GSTM2/UGT2B7/ADH6/AOX1/UGT1A1/ADH7/UGT2B11/CYP2C19/CYP2A7/ADH1C/GSTA2/UGT2A3/GSTA1/UGT2B10/ADH1B/MGST1/MGST2/GSTM4/FMO4/UGT2B15/ADH5/GSTK1/GSTT1/GSTM3/UGT2A1/ADH4/FMO2/CYP2C8	51
KEGG	hsa04510	Focal adhesion	136/5183	201/8144	0.1298	0.3097	0.2333	LAMA3/PIK3CD/PARVG/RAPGEF1/SHC1/MYL7/ITGA5/ACTB/TLN2/TNXB/IBSP/VTN/MAPK3/LAMA5/KDR/PDGFA/LAMB4/CAV3/FYN/THBS3/DIAPH1/THBS4/MYL9/CCND2/HGF/VCL/TNC/CDC42/ERBB2/TLN1/PAK1/GRB2/ITGB6/PTK2/PTEN/ITGA6/ZYX/ITGB3/ITGB4/MYLK/COL1A1/SHC2/BIRC2/MAPK10/COL6A2/LAMA4/RAC1/SHC4/MET/AKT2/MYL10/FLT4/PIK3R2/COL4A2/ITGA1/ITGA11/COL4A4/MAPK1/MYL5/ITGB7/MAPK9/COMP/SPP1/COL9A2/PDGFB/PIK3R1/TNN/HRAS/RAF1/FLNC/COL6A6/EGFR/MYL2/CAV1/BCAR1/COL6A1/PDGFC/PDGFD/MYLPF/RAP1B/VAV2/BIRC3/MAP2K1/EGF/PAK4/BCL2/ITGA4/ITGB1/THBS2/LAMA2/COL4A3/IGF1R/RAC2/LAMA1/CCND3/COL2A1/LAMC3/CTNNB1/ITGA2B/PARVB/PIK3R3/ARHGAP5/COL9A3/RAP1A/CAPN2/PAK2/MYL12A/SOS2/PPP1R12B/PIK3CB/PDGFRA/RAC3/PXN/VAV1/ROCK1/ITGA3/COL6A3/ITGB5/ITGAV/FN1/ROCK2/VEGFC/PDGFRB/ITGA7/BRAF/CHAD/PAK3/PRKCB/PIP5K1B/LAMB2/ITGA10/CAV2/SOS1/PIP5K1A/VWF/ACTG1	136
KEGG	hsa04380	Osteoclast differentiation	88/5183	128/8144	0.1312	0.3108	0.2341	LCK/TYROBP/PIK3CD/OSCAR/IL1B/SPI1/TNF/IFNG/IFNGR2/FCGR2A/JAK1/NFATC2/MITF/SYK/MAPK3/SIRPA/TREM2/FYN/LILRB4/FCGR1A/PPARG/TNFRSF1A/SQSTM1/NFKBIA/IL1R1/TGFBR2/NCF4/GRB2/NFKB1/NCF2/ITGB3/NFATC1/CTSK/CYLD/MAPK10/RAC1/AKT2/MAPK12/PIK3R2/FOSL2/SIRPG/FCGR3B/MAP3K14/JUND/TRAF6/MAPK1/SIRPB1/IRF9/MAPK9/LILRA1/PIK3R1/FCGR3A/ACP5/MAP2K6/TGFB2/LILRB5/LILRB1/TNFRSF11B/LILRA4/CYBA/PPP3R1/MAP2K1/PPP3CA/LCP2/STAT1/NCF1/RELA/SOCS1/PPP3CC/PPP3CB/PIK3R3/TEC/LILRB3/TGFBR1/PLCG2/MAPK14/NFKB2/PIK3CB/FOSB/PPP3R2/FOS/IFNAR2/LILRB2/RELB/CSF1R/GAB2/CREB1/CAMK4	88
KEGG	hsa04962	Vasopressin-regulated water reabsorption	32/5183	44/8144	0.135	0.3176	0.2393	DYNC1LI2/DCTN2/CREB3L2/ARHGDIB/CREB3L4/RAB5C/PRKACA/CREB5/AVP/AQP3/ADCY3/DYNC2LI1/ARHGDIG/ADCY6/NSF/CREB3L3/DCTN6/CREB3/DYNLL2/DYNC1I1/DCTN4/PRKACB/DYNC2H1/GNAS/RAB11B/STX4/DYNC1H1/DYNC1I2/RAB11A/AQP4/CREB1/DCTN1	32
KEGG	hsa04979	Cholesterol metabolism	36/5183	50/8144	0.1383	0.3205	0.2414	VDAC2/PLTP/APOA4/SORT1/ABCG8/NPC1/ABCG5/APOH/CD36/STAR/LRP1/VAPA/SOAT2/LIPA/NCEH1/APOC3/CETP/LPA/LRP2/LDLR/VAPB/TSPO/ABCA1/NPC2/MYLIP/CYP7A1/STARD3/APOA2/LCAT/SOAT1/ABCB11/APOA1/APOB/LIPC/OSBPL5/SCARB1	36
KEGG	hsa04658	Th1 and Th2 cell differentiation	64/5183	92/8144	0.1399	0.3205	0.2414	CD247/CD3D/IL2RB/CD3G/LCK/RUNX3/CD3E/IFNG/IFNGR2/IL12RB2/ZAP70/JAK1/NFATC2/STAT5A/MAPK3/IL5/IL2/HLA-DMB/IL13/MAML1/JAG2/NFKBIA/NFKB1/IL4/HLA-DOA/NFATC1/IL12B/IL2RA/MAPK10/IL4R/TBX21/MAPK12/CD4/HLA-DQA1/PLCG1/HLA-DRA/MAPK1/MAPK9/STAT6/DLL3/NFKBIB/IL12RB1/HLA-DQA2/LAT/PPP3R1/PPP3CA/STAT1/NFKBIE/HLA-DPB1/RELA/HLA-DOB/PPP3CC/HLA-DMA/PPP3CB/MAML2/DLL4/MAPK14/NOTCH2/MAF/STAT5B/PPP3R2/FOS/IL2RG/NFATC3	64
KEGG	hsa05222	Small cell lung cancer	64/5183	92/8144	0.1399	0.3205	0.2414	LAMA3/PIK3CD/E2F1/TRAF1/BCL2L1/LAMA5/LAMB4/RXRA/CDKN2B/GADD45G/NFKBIA/RARB/CDKN1A/TP53/PTK2/NFKB1/PTEN/ITGA6/FHIT/BIRC2/LAMA4/AKT2/RXRG/PIK3R2/CDK6/COL4A2/COL4A4/TRAF6/TRAF5/PIK3R1/ZBTB17/CASP3/CASP9/CYCS/E2F3/PTGS2/BIRC7/BIRC3/BCL2/ITGB1/CDK2/LAMA2/COL4A3/LAMA1/LAMC3/RELA/ITGA2B/NOS2/PIK3R3/GADD45A/TRAF4/E2F2/PIK3CB/ITGA3/CCNE1/ITGAV/FN1/TRAF3/CKS1B/POLK/RXRB/CDKN1B/LAMB2/RB1	64
KEGG	hsa04340	Hedgehog signaling pathway	40/5183	56/8144	0.1404	0.3205	0.2414	CSNK1E/ARRB2/GPR161/GLI2/MGRN1/CCND2/SPOPL/MEGF8/CUL3/DHH/PRKACA/EFCAB7/SMO/CSNK1A1L/ARRB1/EVC2/BTRC/GLI3/PTCH2/SHH/SMURF1/LRP2/FBXW11/HHATL/GAS1/IHH/SCUBE2/CSNK1A1/BCL2/CSNK1G1/KIF7/DISP1/CSNK1G2/PRKACB/HHAT/BOC/PTCH1/SPOP/EVC/KIF3A	40
KEGG	hsa04370	VEGF signaling pathway	42/5183	59/8144	0.1411	0.3205	0.2414	PIK3CD/NFATC2/SH2D2A/MAPK3/KDR/PLA2G4A/CDC42/PTK2/PLA2G4E/SHC2/PLA2G4D/RAC1/AKT2/MAPK12/PIK3R2/NRAS/PLCG1/MAPK1/PLA2G4C/MAP2K2/PIK3R1/HRAS/RAF1/KRAS/CASP9/PTGS2/MAPKAPK2/PPP3R1/MAP2K1/PPP3CA/RAC2/PPP3CC/PPP3CB/PIK3R3/PLCG2/MAPK14/PIK3CB/PLA2G4F/RAC3/PXN/PPP3R2/PRKCB	42
KEGG	hsa04520	Adherens junction	50/5183	71/8144	0.1421	0.3206	0.2415	CTNND1/TCF7/PTPN6/PTPRJ/ACTB/SORBS1/MAPK3/FYN/LEF1/IQGAP1/PARD3/VCL/WASF3/CDC42/ERBB2/TGFBR2/PTPRF/BAIAP2/CTNNA3/TCF7L1/PTPRM/RAC1/MET/CTNNA1/EP300/MAPK1/SNAI1/CDH1/TJP1/LMO7/EGFR/FGFR1/CSNK2A1/NLK/CSNK2B/INSR/CSNK2A2/IGF1R/RAC2/CTNNA2/CTNNB1/FER/TCF7L2/TGFBR1/SMAD4/SNAI2/CREBBP/RAC3/SMAD3/ACTG1	50
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	131/5183	194/8144	0.1437	0.3222	0.2427	GNGT2/PIK3CD/TCF7/HLA-E/CCR8/E2F1/IKBKE/ZFP36/CALML3/JAK1/GNB3/NFATC2/CALML6/ITPR1/CALML4/SYK/MAPK3/CXCL1/LEF1/IFNA7/CALML5/CXCL2/TNFRSF1A/GNG11/NFKBIA/STAT3/CDKN1A/HLA-F/TP53/NFKB1/CCR5/HIF1A/TCF7L1/IL6ST/MICB/FADD/IFNA8/NFATC1/MAPK10/RAC1/AKT2/CASP8/MAPK12/HLA-B/PIK3R2/CDK6/UBB/EP300/CSF2/ITPR2/NRAS/PLCG1/MAPK1/ICAM1/CXCL3/GNGT1/IRF9/LYN/PIK3R5/MAPK9/CCR3/GNG4/MAP2K2/PDGFB/PIK3R1/HRAS/RAF1/MAP1LC3B/CCR1/CASP3/HCK/CALM1/MAP2K4/MAP2K6/KRAS/CASP9/GNB4/CYCS/E2F3/TICAM1/UBC/ANGPT2/PTGS2/MAPKAPK2/CALM2/GNG2/MAP1LC3A/PPP3R1/MAP2K1/PPP3CA/PIK3R6/GNG7/STAT1/EIF2AK2/GNG8/RELA/PIK3CG/CTNNB1/PPP3CC/PPP3CB/PIK3R3/C3/TCF7L2/RCAN1/IFNA4/IFNA14/PLCG2/MAPK14/CREBBP/FGF2/TBK1/GNG3/E2F2/PIK3CB/GNB1/GNG5/PPP3R2/FOS/TRAF3/MTOR/CALM3/IFNAR2/IRF3/GNG10/RB1/BID/MICA/NFATC3/CCR4/CREB1/MAP1LC3B2	131
KEGG	hsa04218	Cellular senescence	106/5183	156/8144	0.1478	0.3291	0.2479	ETS1/HIPK3/RASSF5/PIK3CD/HLA-E/ZFP36L1/VDAC2/E2F1/CALML3/NFATC2/CALML6/ITPR1/CALML4/MAPK3/RBL1/SMAD2/TRAF3IP2/CALML5/CDKN2B/SQSTM1/GADD45G/CCND2/CDKN1A/SLC25A31/TGFBR2/HLA-F/KIR2DL4/TP53/NFKB1/PTEN/LIN54/FOXO3/CDKN2A/NFATC1/BTRC/CCNA1/AKT2/MAPK12/HLA-B/PIK3R2/CDK6/IGFBP3/ITPR2/NRAS/MAPK1/RAD9B/FBXW11/TSC2/RRAS/MAP2K2/PIK3R1/HRAS/RAF1/EIF4EBP1/TSC1/CALM1/MAP2K6/KRAS/LIN52/MDM2/TGFB2/E2F3/MAPKAPK2/SERPINE1/ATM/CALM2/RHEB/PPP3R1/MAP2K1/CCNB3/RAD50/PPP3CA/FOXO1/CDK2/CCND3/HUS1/RELA/PPP3CC/LIN37/HIPK4/GATA4/PPP3CB/PIK3R3/FOXM1/GADD45A/CHEK2/TGFBR1/PPID/CAPN2/MAPK14/E2F2/PIK3CB/MAP2K3/ZFP36L2/HIPK2/E2F4/CCNE1/PPP3R2/SMAD3/MTOR/RBL2/CALM3/LIN9/RB1/NFATC3/CAPN1	106
KEGG	hsa04144	Endocytosis	168/5183	251/8144	0.1504	0.3311	0.2494	IL2RB/FOLR3/VPS37C/RAB31/HLA-E/EEA1/CYTH1/CBL/RAB10/ARRB2/SMAP2/GRK6/ARF5/CXCR4/EHD1/ARFGAP3/CAPZA3/PARD6B/SMAD2/WIPF2/CAV3/CHMP7/FGFR3/FOLR1/RAB5C/VPS29/RAB35/HSPA8/PARD3/CDC42/HGS/TGFBR2/DNAJC6/IQSEC2/HLA-F/GIT2/DNM1/PSD3/WIPF1/CCR5/FGFR4/CAPZA2/CXCR2/STAMBP/GIT1/ARAP3/EPS15L1/RAB11FIP5/ARRB1/IL2RA/CHMP1A/AGAP4/SH3GL2/AGAP1/HLA-B/CLTA/WIPF3/ARFGAP1/PLD1/SMURF1/CYTH4/SH3GLB2/STAM/TRAF6/DNM3/LDLR/ACAP1/AMPH/RAB4A/CAPZB/ASAP2/EHD3/KIF5B/CBLC/HRAS/ARF1/GRK1/ARPC4/EGFR/AGAP5/CAV1/VPS37D/VPS28/SNX32/ARAP2/SH3GL1/MDM2/CLTC/VPS25/DAB2/ARF6/ARAP1/AP2M1/CHMP4A/USP8/PARD6A/PIP5KL1/PLD2/IQSEC3/HSPA1A/GRK7/HSPA2/BIN1/EPN1/WWP1/NEDD4L/HSPA1L/ARFGEF2/PRKCZ/FOLR2/VPS37B/ZFYVE16/AGAP3/CBLB/SNX5/IGF1R/CHMP1B/FGFR2/KIF5C/PSD4/AP2A2/AGAP6/VPS26B/CYTH3/SNX2/SNX3/EPN3/SPG21/RAB11B/TGFBR1/ZFYVE9/EPN2/ARFGAP2/ACTR3C/CYTH2/SH3GL3/CAPZA1/PDGFRA/VPS26A/ACTR2/ACAP2/PDCD6IP/ARPC5L/EHD4/PRKCI/ITCH/SMAD3/ACTR3B/CHMP4C/AP2S1/EHD2/RAB11FIP3/IGF2R/RAB11A/DNM2/IL2RG/PIP5K1B/RABEP1/ASAP3/CAV2/CHMP4B/SMAP1/EPS15/PIP5K1A/PSD2/VPS45/VPS4A/ACAP3	168
KEGG	hsa04668	TNF signaling pathway	77/5183	112/8144	0.1507	0.3311	0.2494	LTA/PIK3CD/IL1B/TNF/TRAF1/MMP14/CCL5/CREB3L2/CASP10/MAPK3/CXCL1/CREB3L4/CXCL2/TNFRSF1A/MMP9/NOD2/NFKBIA/CXCL6/SELE/RIPK1/NFKB1/DAB2IP/RPS6KA5/CCL20/CREB5/FADD/BIRC2/CXCL10/MAPK10/AKT2/MAP3K8/CASP8/MAPK12/PIK3R2/MMP3/CSF2/MAP3K14/TNFRSF1B/MAP3K5/MAPK1/TRAF5/ICAM1/IL15/CX3CL1/CXCL3/MAPK9/PIK3R1/ATF2/CASP3/MAP2K4/CREB3L3/MAP2K6/CFLAR/PTGS2/CREB3/BIRC3/TNFAIP3/MAP2K1/MLKL/EDN1/IL18R1/RELA/PIK3R3/BAG4/IRF1/MAPK14/LIF/PIK3CB/MAP2K3/CCL2/BCL3/FOS/ITCH/TRAF3/VEGFC/ATF4/CREB1	77
KEGG	hsa01250	Biosynthesis of nucleotide sugars	27/5183	37/8144	0.1558	0.3379	0.2545	UAP1/UXS1/PGM3/NANS/GCK/PGM1/GALK2/MIOX/MPI/TSTA3/HKDC1/GMPPB/GALK1/GPI/HK3/GALT/UGDH/UGP2/HK1/GMPPA/GALE/GMDS/PGM2/NAGK/FPGT/PMM2/NANP	27
KEGG	hsa05216	Thyroid cancer	27/5183	37/8144	0.1558	0.3379	0.2545	TCF7/MAPK3/NCOA4/LEF1/PPARG/RXRA/GADD45G/CDKN1A/TP53/TCF7L1/RXRG/NRAS/MAPK1/CCDC6/CDH1/MAP2K2/HRAS/KRAS/MAP2K1/TPM3/CTNNB1/TCF7L2/GADD45A/RET/POLK/BRAF/RXRB	27
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	35/5183	49/8144	0.1617	0.3444	0.2594	UAP1/CYB5R3/UXS1/PGM3/NANS/GCK/PGM1/CYB5R2/GALK2/MPI/TSTA3/HKDC1/GMPPB/GALK1/CHIT1/CYB5R1/CHIA/GPI/HK3/GALT/UGDH/NPL/UGP2/HK1/GMPPA/AMDHD2/GALE/HEXA/GMDS/PGM2/NAGK/HEXB/FPGT/PMM2/NANP	35
KEGG	hsa04672	Intestinal immune network for IgA production	35/5183	49/8144	0.1617	0.3444	0.2594	CD28/LTBR/TNFSF13/IL10/TNFRSF13B/CXCR4/IL5/IL2/HLA-DMB/TNFSF13B/AICDA/CCL28/IL4/HLA-DOA/TNFRSF17/PIGR/ICOS/CCR9/MAP3K14/HLA-DQA1/CD40/HLA-DRA/IL15/ITGB7/HLA-DQA2/IL15RA/ITGA4/MADCAM1/HLA-DPB1/HLA-DOB/HLA-DMA/CD80/CD40LG/TNFRSF13C/CCR10	35
KEGG	hsa05230	Central carbon metabolism in cancer	49/5183	70/8144	0.1622	0.3444	0.2594	PIK3CD/MAPK3/SLC16A3/FGFR3/GCK/FLT3/ERBB2/TP53/PTEN/HIF1A/SLC2A1/SCO2/MET/AKT2/PIK3R2/HKDC1/NRAS/LDHAL6B/MAPK1/GLS/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/HK3/KRAS/NTRK3/SLC1A5/FGFR1/KIT/MAP2K1/FGFR2/LDHA/PDHB/LDHB/HK1/GLS2/PIK3R3/PGAM4/PIK3CB/PDGFRA/RET/MTOR/PDGFRB/PGAM2/LDHC/IDH2/SIRT3	49
KEGG	hsa05213	Endometrial cancer	41/5183	58/8144	0.1629	0.3444	0.2594	PIK3CD/TCF7/MAPK3/LEF1/GADD45G/CDKN1A/ERBB2/GRB2/TP53/CTNNA3/PTEN/TCF7L1/FOXO3/AXIN2/AKT2/PIK3R2/CTNNA1/NRAS/MAPK1/CDH1/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/KRAS/CASP9/MAP2K1/AXIN1/EGF/CTNNA2/CTNNB1/PIK3R3/TCF7L2/GADD45A/APC/SOS2/PIK3CB/POLK/BRAF/SOS1	41
KEGG	hsa04514	Cell adhesion molecules	101/5183	149/8144	0.1648	0.3462	0.2608	CD28/PDCD1/ITGAL/CD2/TIGIT/CD34/HLA-E/CD22/MPZL1/ICAM2/LRRC4/CLDN15/SPN/CLDN22/PECAM1/VTCN1/PTPRC/CLDN18/CLDN16/HLA-DMB/CD8B/NFASC/CD226/CLDN1/CLDN19/GLG1/CTLA4/CLDN14/CLDN17/HLA-F/PTPRF/SELE/F11R/ITGA6/ITGAM/CDH4/HLA-DOA/CNTN2/CLDN11/CLDN7/LRRC4C/CDH5/NCAM2/PTPRM/NRCAM/ESAM/NLGN3/CDH2/HLA-B/CD4/ICOS/ITGB2/HLA-DQA1/MPZ/CD40/HLA-DRA/CD6/CADM3/ICAM1/CDH1/VCAN/ITGB7/NLGN2/NEGR1/CLDN25/IGSF11/CDH3/HLA-DQA2/CLDN6/CD58/CNTNAP2/ITGA4/ITGB1/CLDN9/CDH15/MADCAM1/CLDN3/ALCAM/NLGN1/HLA-DPB1/SIGLEC1/SDC1/HLA-DOB/SDC2/HLA-DMA/NEO1/CD8A/NRXN3/NTNG2/SDC3/SDC4/CD80/CD40LG/NCAM1/CLDN20/CNTN1/ITGAV/PDCD1LG2/SELPLG/CD274/CADM1	101
KEGG	hsa05135	Yersinia infection	93/5183	137/8144	0.1709	0.3568	0.2688	TLR4/LCK/PIK3CD/IL1B/IL10/TNF/IL18/RPS6KA1/PYCARD/FCGR2A/NLRC4/ITGA5/ZAP70/ELMO1/ACTB/NLRP3/ARHGEF1/NFATC2/MAPK3/IL2/CD8B/WIPF2/SKAP2/NFKBIA/CDC42/GIT2/BAIAP2/PTK2/NFKB1/CASP1/WIPF1/NFATC1/MAPK10/RAC1/AKT2/MAPK12/PKN1/PIK3R2/CD4/IRAK4/WIPF3/PLCG1/TRAF6/MAPK1/MAPK9/MAP2K2/PIK3R1/ARPC4/BCAR1/MAP2K4/PTK2B/MAP2K6/ARF6/TICAM1/VAV2/LAT/GNAQ/ARHGEF12/MAP2K1/RHOG/ITGA4/ITGB1/LCP2/ARHGEF7/RAC2/RELA/LIMK1/CD8A/PIK3R3/RPS6KA2/MAPK14/ACTR3C/TBK1/MEFV/PIK3CB/MAP2K3/CCL2/RAC3/PXN/ACTR2/VAV1/ROCK1/ELMO2/FN1/ARPC5L/FOS/ROCK2/ACTR3B/IRF3/PIP5K1B/NFATC3/PIP5K1A/ACTG1	93
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	20/5183	27/8144	0.1774	0.368	0.2772	FUT4/FUT7/FUT1/FUT5/B3GNT2/B3GALNT1/B3GNT5/FUT9/B4GALT1/ST3GAL4/FUT6/B3GALT5/ST3GAL3/B4GALT3/A4GALT/ST8SIA1/B3GALT2/B3GNT4/GCNT2/ST3GAL6	20
KEGG	hsa00053	Ascorbate and aldarate metabolism	22/5183	30/8144	0.1808	0.3706	0.2792	UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/UGT1A3/ALDH2/UGT2B7/MIOX/UGT1A1/UGT2B11/KL/ALDH3A2/UGT2A3/UGT2B10/ALDH7A1/UGDH/UGT2B15/ALDH9A1/UGT2A1	22
KEGG	hsa04010	MAPK signaling pathway	195/5183	294/8144	0.1809	0.3706	0.2792	FASLG/PTPN7/IL1B/TNF/AREG/DUSP2/RPS6KA1/ARRB2/FGF21/FGF6/MKNK1/MKNK2/TAOK3/FGF1/GNA12/DUSP6/MAPK3/RASGRP1/CDC25B/CACNG1/CACNA1G/KDR/PDGFA/DUSP3/MAP3K3/PLA2G4A/CACNA2D3/CACNG5/RAPGEF2/MAP3K13/FGFR3/TNFRSF1A/GADD45G/FLT3/HGF/HSPA8/IL1R1/CDC42/ERBB2/FGF4/TGFBR2/PAK1/GRB2/TP53/CACNA1H/NFKB1/MAP4K4/STK3/PRKACA/INS/FGF17/RPS6KA5/FGFR4/CACNA1A/NGFR/PLA2G4E/NTF3/CACNA1E/CACNG8/TGFA/PLA2G4D/FGF5/NFATC1/ARRB1/FGF10/MAPK10/ANGPT4/MAP4K2/RAC1/MET/AKT2/MAP3K8/MAPK12/EPHA2/FLT4/CACNA2D1/IRAK4/IL1RAP/NR4A1/DDIT3/DUSP7/MAP3K2/MAP3K14/NRAS/JUND/FGF22/MAP3K5/TRAF6/MAPK1/PLA2G4C/RASGRF2/MECOM/STK4/CACNA1S/RASGRP4/MAPK9/MAP4K3/FGF19/RRAS/MAP2K2/PDGFB/FGF3/FLT3LG/HRAS/RAF1/ATF2/FLNC/EGFR/CASP3/DUSP10/MAP2K4/MAP2K6/KRAS/MAP3K11/CACNG4/BDNF/TGFB2/PDGFC/ANGPT2/NF1/PDGFD/MAPKAPK2/MAP3K1/RAP1B/FGFR1/ERBB3/KIT/PPP3R1/HSPA1A/MAP2K1/NLK/PPP3CA/DUSP5/HSPA2/EGF/CACNA1B/HSPA1L/IGF2/FGF16/INSR/MEF2C/IGF1R/RAC2/FGFR2/CD14/NTRK2/RELA/PPP3CC/RASGRP3/PPP3CB/PRKACB/EREG/CACNB1/GADD45A/MAP3K4/RPS6KA2/RAP1A/TGFBR1/MAPK14/NFKB2/PAK2/MAPK7/FGF2/SOS2/MAP2K3/PLA2G4F/DUSP8/MAPK8IP2/PDGFRA/RAC3/CACNG6/EFNA3/CACNA2D2/KITLG/CACNB4/FGF18/PPP3R2/FOS/TEK/RASA2/MAP3K6/VEGFC/FGF8/CACNG2/PDGFRB/BRAF/CACNA1I/PRKCB/RELB/NFATC3/CSF1R/SOS1/ATF4/CACNG7/MAP2K5	195
KEGG	hsa03410	Base excision repair	24/5183	33/8144	0.1834	0.3735	0.2813	MPG/UNG/NEIL1/XRCC1/NTHL1/NEIL3/PARP4/POLL/OGG1/SMUG1/POLE/MBD4/POLD4/HMGB1/PARP2/PARP1/POLD3/MUTYH/PARP3/POLB/LIG1/PCNA/FEN1/APEX1	24
KEGG	hsa05217	Basal cell carcinoma	44/5183	63/8144	0.186	0.3756	0.2829	TCF7/GLI2/WNT8A/LEF1/FZD6/FZD10/GADD45G/CDKN1A/WNT2/WNT11/TP53/TCF7L1/BMP2/FZD8/SMO/WNT10A/FZD2/AXIN2/GLI3/PTCH2/SHH/WNT3A/WNT7A/WNT9B/BMP4/WNT5A/DVL1/WNT2B/AXIN1/KIF7/FZD4/CTNNB1/TCF7L2/WNT9A/GADD45A/APC/WNT7B/WNT1/WNT4/WNT16/PTCH1/DVL3/POLK/FZD5	44
KEGG	hsa04978	Mineral absorption	42/5183	60/8144	0.1867	0.3756	0.2829	SLC40A1/TRPM6/ATP1A2/SLC34A1/MT1B/SLC34A3/TRPV6/FXYD2/ATP2B2/ATP1A1/CYBRD1/SLC6A19/SLC8A1/MT1M/SLC26A3/MT1G/ATP1B1/MT1A/SLC26A9/HMOX1/SLC34A2/HMOX2/ATP2B3/MT1E/ATP1A4/SLC9A3/MT1H/SLC26A6/S100G/SLC11A2/CLCN2/SLC39A4/TF/ATP2B4/SLC8A3/HEPHL1/SLC8A2/MT2A/MT1F/ATP1B2/ATP1A3/FTL	42
KEGG	hsa00910	Nitrogen metabolism	13/5183	17/8144	0.2004	0.4009	0.3019	CA7/CA2/CA13/CA1/CA9/GLUL/CPS1/CA6/CA4/CA12/GLUD1/CA5A/CA3	13
KEGG	hsa05140	Leishmaniasis	53/5183	77/8144	0.2037	0.4049	0.305	TLR4/IL1B/IL10/TNF/IFNG/IFNGR2/FCGR2A/PTPN6/JAK1/MAPK3/HLA-DMB/FCGR1A/NFKBIA/MARCKSL1/NCF4/NFKB1/NCF2/CR1/ITGAM/IL4/HLA-DOA/IL12B/MAPK12/EEF1A1/IRAK4/ITGB2/FCGR3B/HLA-DQA1/HLA-DRA/TRAF6/MAPK1/FCGR3A/TGFB2/NFKBIB/PTGS2/HLA-DQA2/CYBA/ITGA4/ITGB1/TLR2/STAT1/NCF1/HLA-DPB1/EEF1A2/RELA/HLA-DOB/HLA-DMA/NOS2/C3/MAPK14/FOS/PRKCB/CR1L	53
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	15/5183	20/8144	0.2072	0.4087	0.3079	CHST11/CHST14/CHST15/CHST13/CSGALNACT1/XYLT2/CHST12/XYLT1/B3GALT6/CSGALNACT2/DSE/B4GALT7/B3GAT3/UST/CHSY1	15
KEGG	hsa04213	Longevity regulating pathway - multiple species	43/5183	62/8144	0.2114	0.4087	0.3079	RPS6KB2/PIK3CD/PRKAA1/PRKAG1/HSPA8/FOXA2/ADCY4/PRKACA/INS/FOXO3/ADCY5/PRKAA2/PRKAG3/AKT2/PIK3R2/NRAS/ADCY3/HDAC1/PIK3R1/HRAS/ADCY6/ADCY2/IRS2/KRAS/ADCY8/IRS1/HSPA1A/HSPA2/ADCY7/HSPA1L/FOXO1/RPS6KB1/INSR/IGF1R/SOD1/ATG5/PRKACB/PIK3R3/PRKAG2/PIK3CB/HDAC2/MTOR/ADCY1	43
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	17/5183	23/8144	0.2118	0.4087	0.3079	ATP1A2/PCK2/FXYD2/CA2/ATP1A1/PCK1/ATP1B1/GLS/ATP1A4/SLC9A3/CA4/SLC4A4/GLUD1/GLS2/SLC25A10/ATP1B2/ATP1A3	17
KEGG	hsa04530	Tight junction	113/5183	169/8144	0.2129	0.4087	0.3079	CD1C/PRKAA1/CD1B/CD1E/CLDN15/RAB13/CLDN22/ACTB/PRKAG1/CLDN18/CLDN16/PARD6B/RAPGEF2/DLG2/CLDN1/MYL9/TJP3/CLDN19/PARD3/PPP2R2C/CLDN14/CDC42/MAGI1/DLG1/ERBB2/CLDN17/F11R/PRKACA/SYMPK/MARVELD2/CLDN11/CLDN7/PRKAA2/EZR/MICALL2/MPP4/MAPK10/MYH9/RAC1/PRKAG3/MPDZ/TUBA3C/CGNL1/MYH10/MAP3K5/MARVELD3/SLC9A3R1/PPP2R2A/ARHGEF18/TJP1/ARHGEF2/MAPK9/TUBA3E/PPP2R2D/TJAP1/ARHGAP17/TUBA4A/CGN/ARPC4/CD1D/TUBA1A/MYL2/TIAM1/CLDN25/TJP2/RAB8B/RUNX1/TUBA3D/MPP5/MAP3K1/CD1A/PPP2CB/CLDN6/PARD6A/MYL6/CRB3/NEDD4L/PRKCZ/ITGB1/CLDN9/TUBA8/CLDN3/STK11/LLGL1/TUBA1B/EPB41L4B/GATA4/PRKACB/PPP2R1A/RAP1A/PRKAG2/HSPA4/MYL12A/ACTR3C/RAPGEF6/ACTR2/ROCK1/AMOTL1/CLDN20/ARPC5L/RDX/PRKCI/ROCK2/IGSF5/ACTR3B/PPP2CA/PCNA/BVES/AMOT/PRKCE/SCRIB/TUBA1C/ACTG1	113
KEGG	hsa04070	Phosphatidylinositol signaling system	66/5183	97/8144	0.2129	0.4087	0.3079	DGKA/PIK3CD/ITPKB/CALML3/SYNJ1/PIK3C2G/CALML6/ITPR1/CALML4/INPP5D/DGKB/CALML5/INPP4A/IP6K3/IPMK/ITPKA/PIKFYVE/INPP5B/PTEN/PLCE1/DGKZ/IMPA1/MTMR3/MTMR14/PLCZ1/IMPA2/DGKI/INPP5A/PIK3C2A/MTMR7/PIP4K2A/PIK3R2/ITPR2/PLCG1/PI4K2B/PIK3R1/CDS2/IPPK/CALM1/PLCB1/SYNJ2/CALM2/PLCD3/IMPAD1/DGKQ/PIP4K2C/PLCB4/PIK3C2B/PLCB2/DGKD/PI4KB/PIK3R3/PLCD4/PLCB3/CDS1/DGKE/INPPL1/DGKH/PLCG2/PLCD1/PI4K2A/PIK3CB/CALM3/PRKCB/PIP5K1B/PIP5K1A	66
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	66/5183	97/8144	0.2129	0.4087	0.3079	RPS6KB2/PIK3CD/FCGR2A/PTPRC/SYK/MAPK3/PRKCD/INPP5D/PLA2G4A/FCGR1A/WASF3/CDC42/MYO10/MARCKSL1/PAK1/GSN/LIMK2/PLA2G4E/PLA2G4D/RAC1/AKT2/MARCKS/PIK3R2/PLD1/FCGR3B/PLCG1/MAPK1/PLA2G4C/LYN/AMPH/ASAP2/PIK3R1/FCGR3A/RAF1/ARPC4/PLA2G6/HCK/ARF6/CFL1/VAV2/LAT/PLD2/MAP2K1/BIN1/RPS6KB1/NCF1/RAC2/CFL2/LIMK1/PIK3R3/INPPL1/PLCG2/ACTR3C/PIK3CB/PLA2G4F/ACTR2/VAV1/ARPC5L/ACTR3B/DNM2/PRKCB/PIP5K1B/ASAP3/PRKCE/GAB2/PIP5K1A	66
KEGG	hsa04152	AMPK signaling pathway	81/5183	120/8144	0.2159	0.412	0.3104	RPS6KB2/PIK3CD/PRKAA1/FBP2/G6PC3/RAB10/CAB39L/PFKFB2/PRKAG1/PCK2/FBP1/CREB3L2/ADIPOR2/CREB3L4/PPARG/PPP2R5C/HNF4A/SCD5/PPP2R2C/EEF2/SREBF1/CD36/INS/PCK1/FOXO3/PRKAA2/GYS2/CREB5/PPP2R5A/CCNA1/CAMKK2/PPP2R5E/PRKAG3/AKT2/PIK3R2/STRADA/PPP2R2A/TSC2/PPP2R2D/G6PC/LEP/CRTC2/LEPR/PIK3R1/ADIPOR1/PPP2R5B/FASN/EIF4EBP1/TSC1/IRS2/CREB3L3/PFKFB3/CREB3/IRS1/PPP2CB/RHEB/PPP2R5D/FOXO1/RPS6KB1/INSR/IGF1R/STK11/CPT1C/ACACA/PIK3R3/PPP2R1A/CAB39/RAB11B/PRKAG2/PIK3CB/ADRA1A/PPP2R3A/SCD/LIPE/RAB14/GYS1/MTOR/PPP2R3C/PPP2CA/RAB2A/CREB1	81
KEGG	hsa05130	Pathogenic Escherichia coli infection	131/5183	197/8144	0.2219	0.4212	0.3172	FASLG/TLR4/IL1B/TNF/IL18/PYCARD/CLDN15/FCGR2A/CYTH1/NCKAP1L/CLDN22/PTPN6/ACTB/NLRP3/ARHGEF1/TLR5/CLDN18/CLDN16/CYFIP1/GNA12/MAPK3/GNA13/NAIP/WIPF2/NLRP4/FYN/TNFRSF1A/CLDN1/TNFSF10/CLDN19/NFKBIA/WASF3/IL1R1/CLDN14/CDC42/MYO10/CLDN17/PAK1/BAIAP2/F2/RIPK1/NFKB1/CASP1/LPAR5/WIPF1/MYO1E/MYO1B/TUBB/CLDN11/LPAR2/CLDN7/EZR/FADD/MYO1C/NCL/MAPK10/TMED10/MYH9/RAB1A/RAC1/RPS3/MYO5C/CASP8/MAPK12/CASP4/TUBA3C/MYH10/IRAK4/WIPF3/CYTH4/SLC9A3R1/TRAF6/MAPK1/ABI1/TJP1/ARHGEF2/MAPK9/TUBA3E/ARHGEF11/TUBA4A/ARF1/ARPC4/TNFRSF10A/NCKAP1/TUBA1A/MYO1D/CASP3/CYFIP2/CASP9/TUBB3/CLDN25/CYCS/ARF6/TUBA3D/GAPDH/NFKBIB/SEC24C/ABL1/CLDN6/TIRAP/LPAR1/ARHGEF12/ITGB1/MYO1H/CLDN9/TUBB8/TUBA8/CLDN3/TUBB2A/RELA/NCK2/TUBA1B/CYTH3/MAPK14/PAK2/ACTR3C/CYTH2/ACTR2/ROCK1/CLDN20/ARPC5L/FOS/ROCK2/ACTR3B/SEC24A/NCK1/PAK3/TNFRSF10B/TUBA1C/ACTG1/MYO1G	131
KEGG	hsa04929	GnRH secretion	44/5183	64/8144	0.2369	0.447	0.3367	PIK3CD/ARRB2/ITPR1/MAPK3/CACNA1G/KISS1/LHB/KCNJ5/CACNA1H/ARRB1/AKT2/KISS1R/PIK3R2/ITPR2/NRAS/MAPK1/CACNA1S/SPP1/MAP2K2/PIK3R1/HRAS/RAF1/KCNN3/GABBR2/KRAS/PLCB1/GNAQ/HCN1/GNRH1/MAP2K1/KCNJ3/KCNN4/KCNN2/PLCB4/CGA/PLCB2/PIK3R3/PLCB3/GABBR1/PIK3CB/TRPC4/CACNA1I/PRKCB/KCNJ6	44
KEGG	hsa05410	Hypertrophic cardiomyopathy	61/5183	90/8144	0.2405	0.4512	0.3399	PRKAA1/TNF/ITGA5/MYH6/ACTB/PRKAG1/SGCA/MYH7/CACNG1/CACNA2D3/CACNG5/ACE/ITGB6/TNNT2/ITGA6/ITGB3/ITGB4/SLC8A1/PRKAA2/ATP2A1/CACNG8/PRKAG3/TNNC1/CACNA2D1/ITGA1/ITGA11/MYBPC3/CACNA1S/ITGB7/SGCG/MYL2/CACNG4/TGFB2/SGCD/TPM3/SGCB/ITGA4/RYR2/ITGB1/LAMA2/LAMA1/EDN1/DES/ITGA2B/CACNB1/SLC8A3/PRKAG2/SLC8A2/CACNG6/CACNA2D2/ITGA3/CACNB4/ITGB5/ITGAV/CACNG2/ITGA7/ITGA10/MYL3/TPM4/CACNG7/ACTG1	61
KEGG	hsa03450	Non-homologous end-joining	10/5183	13/8144	0.2448	0.4568	0.3441	DNTT/PRKDC/NHEJ1/LIG4/POLL/RAD50/XRCC5/DCLRE1C/POLM/FEN1	10
KEGG	hsa04612	Antigen processing and presentation	53/5183	78/8144	0.2514	0.4665	0.3514	CALR/KLRD1/TNF/HLA-E/IFNG/CTSS/KIR3DL2/TAP1/KLRC4/KIR3DL1/HLA-DMB/CD8B/KIR2DL1/KLRC1/CANX/IFI30/HSPA8/HLA-F/TAP2/KIR2DL4/KIR2DL3/NFYC/HLA-DOA/KIR2DS4/CD74/HLA-B/CD4/HLA-DQA1/HLA-DRA/CIITA/PSME3/HSP90AA1/B2M/CTSB/KIR3DL3/KLRC3/HLA-DQA2/RFXAP/HSPA1A/HSPA2/HSPA1L/LGMN/HLA-DPB1/HLA-DOB/HLA-DMA/CD8A/HSPA4/PSME2/HSP90AB1/HSPA5/RFXANK/TAPBP/CREB1	53
KEGG	hsa03320	PPAR signaling pathway	51/5183	75/8144	0.2542	0.4685	0.3529	OLR1/PLTP/NR1H3/SORBS1/PCK2/FABP3/GK2/CYP8B1/ME3/PPARG/RXRA/ACSBG1/FABP2/SCD5/FADS2/UCP1/CD36/HMGCS2/PCK1/MMP1/ACSL3/APOC3/PLIN2/FABP1/RXRG/ACADL/FABP6/ACSBG2/ACOX3/ME1/APOA5/SLC27A6/ACOX2/FABP4/AQP7/SLC27A4/UBC/SLC27A1/CPT2/SLC27A2/CYP7A1/CPT1C/SLC27A5/APOA2/FABP7/ACSL5/PLIN1/SCD/APOA1/FABP5/RXRB	51
KEGG	hsa00531	Glycosaminoglycan degradation	14/5183	19/8144	0.2553	0.4685	0.3529	GLB1/ARSB/HYAL2/HYAL4/SPAM1/HPSE/HYAL3/SGSH/HGSNAT/NAGLU/IDUA/HEXA/HPSE2/HEXB	14
KEGG	hsa00220	Arginine biosynthesis	16/5183	22/8144	0.2572	0.4695	0.3536	ARG1/ARG2/GOT1L1/GLUL/CPS1/GPT/GPT2/GLS/GLUD1/GLS2/NOS2/GOT1/ASS1/OTC/NOS1/NAGS	16
KEGG	hsa04142	Lysosome	88/5183	132/8144	0.2637	0.4763	0.3588	CTSG/SCARB2/CTSZ/CTSA/CTSS/CD68/SLC11A1/GLB1/ARSB/LITAF/SORT1/AP1M1/PPT1/ATP6V0A1/LAPTM4A/NPC1/GALC/DNASE2B/AP1S2/ENTPD4/NAGPA/CLN5/ATP6V0D2/NAPSA/CTNS/HYAL2/HYAL4/GBA/AP1G2/LIPA/SPAM1/CTSK/LAMP1/ATP6V0A4/AGA/CLTA/FUCA2/HYAL3/PSAP/AP3S2/ATP6V0D1/CLN3/AP3M2/AP3B2/AP3D1/MANBA/ACP5/TPP1/ATP6V1H/CD63/MAN2B1/CTSB/CLTC/NEU1/CTSE/SGSH/NPC2/HGSNAT/GNPTG/NAGLU/AP3S1/GGA3/AP1S3/LGMN/SLC11A2/CTSD/SLC17A5/MCOLN1/GAA/WDR7/DNASE2/AP1G1/SMPD1/IDUA/HEXA/AP4S1/ABCA2/TCIRG1/LAMP3/AP1M2/ARSG/NAGA/HEXB/AP3M1/IGF2R/PSAPL1/GNPTAB/CTSC	88
KEGG	hsa05145	Toxoplasmosis	75/5183	112/8144	0.2638	0.4763	0.3588	LAMA3/TLR4/IL10/TNF/IFNG/IFNGR2/IL10RA/IL10RB/JAK1/MAPK3/BCL2L1/HLA-DMB/LAMA5/LAMB4/TNFRSF1A/HSPA8/NFKBIA/STAT3/GNAO1/GNAI3/NFKB1/ITGA6/CCR5/HLA-DOA/BIRC2/IL12B/MAPK10/LAMA4/AKT2/CASP8/MAPK12/IRAK4/HLA-DQA1/CD40/HLA-DRA/TRAF6/CIITA/MAPK1/LDLR/PIK3R5/MAPK9/CASP3/MAP2K6/CASP9/CYCS/TGFB2/NFKBIB/LY96/BIRC7/BIRC3/HLA-DQA2/HSPA1A/PIK3R6/HSPA2/BCL2/GNAI1/HSPA1L/ITGB1/TLR2/STAT1/LAMA2/LAMA1/HLA-DPB1/LAMC3/RELA/PIK3CG/HLA-DOB/SOCS1/HLA-DMA/NOS2/MAPK14/CD40LG/MAP2K3/IRGM/LAMB2	75
KEGG	hsa05152	Tuberculosis	119/5183	180/8144	0.2697	0.4843	0.3648	TLR4/FCER1G/CORO1A/IL1B/IL10/TNF/TLR6/LBP/EEA1/IFNG/RIPK2/CTSS/IL18/IFNGR2/IL10RA/FCGR2A/CALML3/PLK3/CLEC4M/IL10RB/JAK1/CASP10/CALML6/CALML4/SYK/MAPK3/HLA-DMB/FCGR1A/IFNA7/CALML5/RAB5C/ATP6V0A1/TNFRSF1A/IL23A/NOD2/CAMK2A/NFKB1/LSP1/CR1/ATP6V0D2/NFYC/CAMK2B/ITGAM/HLA-DOA/CAMK2G/FADD/IFNA8/IL12B/BCL10/LAMP1/MAPK10/ATP6V0A4/AKT2/CD74/CASP8/MAPK12/IRAK4/ITGB2/EP300/CYP27B1/FCGR3B/HLA-DQA1/HLA-DRA/TRAF6/CIITA/MAPK1/ATP6V0D1/MAPK9/PLA2R1/FCGR3A/RAF1/CASP3/ATP6V1H/CALM1/CASP9/CD209/MALT1/CEBPG/CYCS/TGFB2/CALM2/HLA-DQA2/TIRAP/ARHGEF12/PPP3R1/RFXAP/KSR1/PPP3CA/BCL2/TLR2/STAT1/TLR9/CTSD/TLR1/CD14/HLA-DPB1/RELA/HLA-DOB/PPP3CC/HLA-DMA/NOS2/PPP3CB/C3/IFNA4/IFNA14/MAPK14/HSPA9/CREBBP/CLEC7A/TCIRG1/PPP3R2/RFXANK/CALM3/MRC1/ITGAX/BID/CAMP/CREB1/CR1L	119
KEGG	hsa04068	FoxO signaling pathway	87/5183	131/8144	0.2853	0.5095	0.3838	FASLG/IL7R/PIK3CD/S1PR1/IL10/PRKAA1/CSNK1E/RAG1/G6PC3/PLK3/PRKAG1/PCK2/KLF2/MAPK3/FOXG1/CDKN2B/GADD45G/CCND2/TNFSF10/FBXO32/SGK1/STAT3/CDKN1A/TGFBR2/GRB2/PTEN/INS/PCK1/FOXO3/PRKAA2/MAPK10/SGK2/PLK2/PRKAG3/AKT2/MAPK12/CDKN2D/PIK3R2/EP300/NRAS/MAPK1/STK4/MAPK9/G6PC/MAP2K2/GRM1/PIK3R1/SGK3/HRAS/RAF1/EGFR/HOMER1/IRS2/KRAS/MDM2/TGFB2/ATM/IRS1/MAP2K1/CCNB3/NLK/EGF/USP7/FOXO1/CCNG2/CDK2/INSR/IGF1R/BCL2L11/STK11/PIK3R3/GADD45A/TGFBR1/PRKAG2/SMAD4/MAPK14/CREBBP/PLK1/SOS2/PIK3CB/SMAD3/HOMER2/RBL2/BRAF/CDKN1B/SOS1/RAG2	87
KEGG	hsa05032	Morphine addiction	61/5183	91/8144	0.2879	0.511	0.3849	GNGT2/PDE7A/ARRB2/GRK6/GNB3/PDE8A/GABRR1/PDE11A/GNG11/GNAO1/GNAI3/ADCY4/KCNJ5/PRKACA/GABRA2/CACNA1A/ADCY5/SLC32A1/GABRA4/ARRB1/PDE8B/PDE1A/GABRP/PDE3B/GABRA1/ADCY3/GABRD/GNGT1/GABRA6/GNG4/ADCY6/PDE2A/GABBR2/ADCY2/GABRA5/PDE1B/ADCY8/GNB4/GABRG2/GABRR3/GABRA3/GNG2/KCNJ3/CACNA1B/GNAI1/ADCY7/GNG7/GNG8/PRKACB/DRD1/GNAS/GABBR1/GABRB2/GNG3/PDE4B/GNB1/GNG5/ADCY1/GNG10/PRKCB/KCNJ6	61
KEGG	hsa04630	JAK-STAT signaling pathway	107/5183	162/8144	0.2892	0.511	0.3849	IL2RB/IL7R/PIK3CD/IL10/CISH/IL27RA/IFNG/IFNGR2/SOCS2/IL21/IL10RA/IL12RB2/IL24/PTPN6/IL10RB/JAK1/EPOR/IL23R/STAT5A/IL6R/IFNK/BCL2L1/IL5/GH1/IL2/IL13/TSLP/CSH1/PDGFA/IL22RA1/CSF3R/IFNA7/IL5RA/IL23A/CCND2/STAT3/CDKN1A/IL21R/IL19/GRB2/CTF1/IL4/IL6ST/IL22/THPO/IFNA8/CSF3/IL12B/CNTF/AOX1/IL2RA/IL4R/AKT2/PIK3R2/EP300/CSF2/PRL/IL9/IL11RA/EPO/STAM/SOCS5/IL15/IRF9/LEP/LEPR/PDGFB/PIK3R1/HRAS/RAF1/PIM1/CSF2RB/EGFR/GFAP/STAT6/IL3/PTPN2/SOCS7/IL12RB1/IL15RA/EGF/BCL2/STAT1/IL20RB/CCND3/LIFR/SOCS1/PIK3R3/IFNA4/IFNA14/GH2/CREBBP/SOS2/LIF/PIK3CB/PDGFRA/IL20RA/STAT5B/MTOR/PDGFRB/IFNAR2/IL2RG/PIAS3/PIAS2/IL22RA2/IL7/SOS1	107
KEGG	hsa05171	Coronavirus disease - COVID-19	152/5183	232/8144	0.2985	0.5247	0.3952	TLR4/PIK3CD/IL1B/TNF/RPL13A/IKBKE/FCGR2A/RPL3/RPS11/RPL23A/NLRP3/JAK1/RPS3A/RPL8/HBEGF/IL6R/SYK/MAPK3/RPL7A/FGG/IL2/C1QB/IFNA7/RPS2/RPL3L/TNFRSF1A/C1QA/RPS18/NFKBIA/RPL31/ACE/RPS15A/STAT3/C3AR1/C5AR1/MASP1/CFD/RPLP2/F2/MBL2/TMPRSS2/NFKB1/FGA/RPL18A/CASP1/RPS12/C9/MMP1/RPL15/C2/MASP2/OAS2/IL6ST/MAS1/IFNA8/RPL32/C8B/CSF3/IL12B/RPL6/C7/CXCL10/MAPK10/C6/RPS3/C4A/C4B/RPL27A/RPSA/MAPK12/PIK3R2/RPS28/RPS6/IRAK4/MMP3/CSF2/C8A/RPS9/RPL21/F13B/CFB/PLCG1/TRAF6/MAPK1/IRF9/RPS15/C5/MAPK9/C1QC/RPL5/RPL35A/PIK3R1/RPS13/ISG15/EGFR/RPL14/RPL27/FGB/RPS4X/NFKBIB/RPL10L/RPL17/ACE2/MAVS/RPLP1/RPS29/TLR2/STAT1/EIF2AK2/RPS24/C1R/C8G/RELA/RPL23/RPL13/AGTR1/RPL22L1/RPS10/RPL35/ADAM17/RPS8/RPL26/PIK3R3/C3/IFNA4/IFNA14/PLCG2/MAPK14/TBK1/PIK3CB/CCL2/OAS1/TLR7/TLR8/RPL38/RPL24/RPS4Y1/RSL24D1/RPL29/FOS/RPL36AL/TRAF3/IFNAR2/MX2/RPL37/RPS7/IRF3/RPL26L1/PRKCB/RPS27L/NRP1/VWF	152
KEGG	hsa04966	Collecting duct acid secretion	19/5183	27/8144	0.304	0.5309	0.3999	ATP6V0E2/CLCNKB/CA2/ATP6V0A1/ATP6V0D2/ATP4B/ATP6V0A4/ATP6V1B1/ATP6V1B2/ATP6V1C1/ATP6V1G3/ATP6V0D1/ATP6V1E1/ATP6V0E1/ATP6V1D/ATP6V1F/TCIRG1/ATP4A/SLC4A1	19
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	17/5183	24/8144	0.3068	0.5309	0.3999	HS3ST5/EXTL1/XYLT2/HS3ST1/XYLT1/B3GALT6/HS6ST2/HS6ST1/EXTL3/B4GALT7/B3GAT3/GLCE/EXTL2/HS3ST3B1/NDST2/HS3ST2/HS3ST3A1	17
KEGG	hsa04977	Vitamin digestion and absorption	17/5183	24/8144	0.3068	0.5309	0.3999	PNLIP/APOA4/ABCC1/RBP2/LMBRD1/PLB1/SLC19A1/LRAT/BTD/SLC23A1/SLC5A6/CUBN/TCN2/AWAT2/APOA1/APOB/SCARB1	17
KEGG	hsa00061	Fatty acid biosynthesis	13/5183	18/8144	0.3109	0.5339	0.4022	ACSBG1/OLAH/ACSL3/HSD17B8/ACSF3/ACSBG2/MCAT/OXSM/FASN/MECR/ACACA/CBR4/ACSL5	13
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	11/5183	15/8144	0.3117	0.5339	0.4022	GLB1/ST6GALNAC4/ST6GALNAC3/B3GALT4/ST8SIA1/B4GALNT1/ST8SIA5/ST3GAL5/SLC33A1/HEXA/HEXB	11
KEGG	hsa04922	Glucagon signaling pathway	71/5183	107/8144	0.316	0.5365	0.4041	PRKAA1/FBP2/G6PC3/CALML3/PRKAG1/PCK2/FBP1/CREB3L2/CALML6/ITPR1/CALML4/CREB3L4/CALML5/GCK/CAMK2A/PRKACA/PCK1/CAMK2B/PYGL/SLC2A1/CAMK2G/PHKB/PYGM/PRKAA2/GYS2/CREB5/PRKAG3/AKT2/PDE3B/EP300/ITPR2/GCG/LDHAL6B/G6PC/CRTC2/ATF2/CALM1/ADCY2/CREB3L3/PLCB1/CALM2/CREB3/GNAQ/PPP3R1/PPP3CA/FOXO1/PLCB4/LDHA/PDHB/LDHB/PLCB2/PYGB/CPT1C/PPP3CC/ACACA/PPP3CB/PRKACB/GNAS/PLCB3/PHKG1/PGAM4/PRKAG2/CREBBP/SIK2/PPP3R2/GYS1/CALM3/PGAM2/LDHC/ATF4/CREB1	71
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	47/5183	70/8144	0.3164	0.5365	0.4041	ATP6V0E2/CSK/CCL5/HBEGF/NOD1/CXCL1/CXCL2/ATP6V0A1/NFKBIA/CDC42/PAK1/NFKB1/F11R/ATP6V0D2/CXCR2/GIT1/MAPK10/ATP6V0A4/RAC1/MET/MAPK12/ATP6V1B1/ATP6V1B2/MAP3K14/ATP6V1C1/PLCG1/ADAM10/ATP6V1G3/CXCL3/ATP6V0D1/LYN/TJP1/MAPK9/EGFR/CASP3/ATP6V1H/MAP2K4/RELA/ATP6V1E1/ATP6V0E1/ADAM17/ATP6V1D/ATP6V1F/PLCG2/MAPK14/TCIRG1/IGSF5	47
KEGG	hsa04973	Carbohydrate digestion and absorption	32/5183	47/8144	0.3186	0.5374	0.4048	PIK3CD/G6PC3/ATP1A2/FXYD2/SLC2A5/ATP1A1/GNAT3/AKT2/ATP1B1/PIK3R2/HKDC1/MGAM/SLC37A4/G6PC/PIK3R1/TAS1R3/ATP1A4/HK3/PLCB1/PLCB4/LCT/AMY2B/TAS1R2/HK1/PLCB2/PIK3R3/PLCB3/AMY2A/PIK3CB/ATP1B2/ATP1A3/PRKCB	32
KEGG	hsa04620	Toll-like receptor signaling pathway	69/5183	104/8144	0.3202	0.5375	0.4049	TLR4/IRF5/PIK3CD/IL1B/TNF/TLR6/LBP/IKBKE/CCL5/TLR5/CXCL9/MAPK3/IFNA7/NFKBIA/TICAM2/CXCL11/RIPK1/NFKB1/CCL4/FADD/IFNA8/IL12B/CTSK/CXCL10/MAPK10/RAC1/AKT2/MAP3K8/CASP8/MAPK12/PIK3R2/IRAK4/CD40/TRAF6/MAPK1/MAPK9/SPP1/MAP2K2/PIK3R1/MAP2K4/MAP2K6/TICAM1/LY96/CCL3/TIRAP/MAP2K1/TLR2/STAT1/TLR9/TLR1/CD14/RELA/PIK3R3/IFNA4/CD80/IFNA14/MAPK14/TBK1/PIK3CB/MAP2K3/TLR7/TLR8/CCL3L1/CCL3L3/FOS/TRAF3/IFNAR2/TOLLIP/IRF3	69
KEGG	hsa04723	Retrograde endocannabinoid signaling	97/5183	148/8144	0.3476	0.5805	0.4373	GNGT2/NDUFS8/NDUFS2/GNB3/ITPR1/MAPK3/GRIA1/GABRR1/CNR1/GNG11/GRIA4/GNAO1/GNAI3/RIMS1/ADCY4/DAGLB/KCNJ5/PRKACA/NDUFB6/GABRA2/GRIA2/CACNA1A/ADCY5/SLC32A1/NDUFA7/GABRA4/NDUFB10/NDUFA5/MAPK10/GABRP/MAPK12/GABRA1/NDUFB8/ITPR2/ADCY3/MAPK1/GABRD/GNGT1/CACNA1S/MAPK9/NDUFV2/GABRA6/GNG4/GRM1/ADCY6/ADCY2/NDUFAB1/GABRA5/ADCY8/GNB4/GABRG2/PLCB1/NDUFS6/PTGS2/NDUFV1/GABRR3/GABRA3/NDUFC1/GNAQ/GNG2/DAGLA/SLC17A6/KCNJ3/NDUFS5/CACNA1B/NDUFS7/GNAI1/ADCY7/GNG7/PLCB4/GNG8/PLCB2/ABHD6/NDUFS1/GRM5/NDUFA4L2/PRKACB/PLCB3/NDUFA11/NAPEPLD/MAPK14/SLC17A8/GABRB2/GNG3/NDUFA10/GNB1/NDUFB5/GNG5/NDUFA6/ADCY1/NDUFA8/NDUFB1/GNG10/PRKCB/NDUFB2/KCNJ6/SLC17A7	97
KEGG	hsa00565	Ether lipid metabolism	33/5183	49/8144	0.3521	0.585	0.4407	PLA2G2D/PLA2G4A/PLA2G2F/PLD3/PLA2G1B/PLB1/TMEM189/PLA2G4E/PLA2G4D/PLA2G2E/ENPP6/PLD1/PLA2G2C/PLA2G2A/PLA2G7/PLA2G4C/TMEM86B/GAL3ST1/PLA2G10/PLA2G5/PLA2G6/PLA2G12A/PLA2G3/PLD2/PLA2G12B/CHPT1/PAFAH1B3/PAFAH2/GDPD1/PLA2G4F/CEPT1/UGT8/LPCAT2	33
KEGG	hsa04940	Type I diabetes mellitus	29/5183	43/8144	0.3642	0.602	0.4534	FASLG/LTA/PRF1/CD28/GZMB/IL1B/TNF/HLA-E/IFNG/IL2/HLA-DMB/HLA-F/INS/PTPRN2/HLA-DOA/IL12B/HLA-B/HLA-DQA1/HLA-DRA/ICA1/HLA-DQA2/GAD2/PTPRN/HLA-DPB1/HLA-DOB/HLA-DMA/CD80/GAD1/CPE	29
KEGG	hsa04210	Apoptosis	89/5183	136/8144	0.3659	0.602	0.4534	FASLG/PRF1/DIABLO/GZMB/PIK3CD/CTSZ/TNF/CASP6/CTSS/TRAF1/ACTB/CASP10/ITPR1/MAPK3/BCL2L1/BCL2A1/TP53AIP1/TNFRSF1A/GADD45G/TNFSF10/NFKBIA/CASP2/RIPK1/TP53/NFKB1/DAB2IP/FADD/PTPN13/BIRC2/CTSK/MAPK10/AKT2/CASP8/PIK3R2/TUBA3C/DDIT3/MAP3K14/ITPR2/NRAS/MAP3K5/MAPK1/ENDOG/MAPK9/TUBA3E/MAP2K2/PIK3R1/TUBA4A/HRAS/RAF1/CSF2RB/TNFRSF10A/TUBA1A/CASP3/IL3/KRAS/CASP9/PARP4/CTSB/CFLAR/CYCS/TUBA3D/ATM/BIRC3/MAP2K1/BCL2/PMAIP1/EIF2AK3/CTSD/TUBA8/BCL2L11/RELA/TUBA1B/PARP2/PIK3R3/PARP1/GADD45A/CAPN2/PIK3CB/BBC3/PARP3/FOS/BID/CTSC/TNFRSF10B/LMNB2/ATF4/CAPN1/TUBA1C/ACTG1	89
KEGG	hsa00120	Primary bile acid biosynthesis	12/5183	17/8144	0.3741	0.6125	0.4613	CYP8B1/AKR1D1/AKR1C4/CYP39A1/BAAT/CYP7B1/ACOX2/AMACR/CYP7A1/SLC27A5/HSD17B4/HSD3B7	12
KEGG	hsa00040	Pentose and glucuronate interconversions	23/5183	34/8144	0.385	0.6273	0.4725	UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/UGT1A3/AKR1B10/UGT2B7/UGT1A1/UGT2B11/KL/UGT2A3/UGT2B10/UGDH/UGP2/UGT2B15/RPE/UGT2A1/DCXR/CRYL1/XYLB	23
KEGG	hsa00052	Galactose metabolism	21/5183	31/8144	0.3929	0.637	0.4798	G6PC3/LALBA/GLB1/GCK/PGM1/AKR1B10/B4GALT1/GANC/HKDC1/GALK1/MGAM/G6PC/HK3/GALT/UGP2/LCT/HK1/GALM/GAA/GALE/PGM2	21
KEGG	hsa02010	ABC transporters	30/5183	45/8144	0.3998	0.645	0.4859	TAP1/ABCC1/ABCB6/DEFB1/ABCA9/ABCG8/ABCC12/ABCG5/TAP2/ABCD4/ABCC6/ABCC9/ABCA3/ABCA4/ABCA12/ABCG1/ABCC10/ABCB5/ABCB8/ABCA1/ABCC3/ABCA13/ABCD2/ABCA7/ABCA2/ABCC5/ABCB11/ABCA5/ABCC2/ABCA8	30
KEGG	hsa01524	Platinum drug resistance	48/5183	73/8144	0.4036	0.6481	0.4882	FASLG/MSH6/PIK3CD/GSTT2B/ERCC1/MAPK3/GSTA5/BCL2L1/GSTP1/GSTA4/GSTT2/CDKN1A/ERBB2/GSTM2/TP53/CDKN2A/FADD/BIRC2/AKT2/CASP8/PIK3R2/MAP3K5/MAPK1/TOP2B/GSTA2/GSTA1/PIK3R1/CASP3/MSH3/CASP9/CYCS/MDM2/MSH2/ATM/BIRC3/MGST1/BCL2/PMAIP1/MGST2/PIK3R3/GSTM4/XPA/GSTT1/GSTM3/PIK3CB/BBC3/ABCC2/BID	48
KEGG	hsa05170	Human immunodeficiency virus 1 infection	137/5183	212/8144	0.412	0.6584	0.4959	FASLG/CD247/CD3D/CD3G/TLR4/CD3E/RPS6KB2/GNGT2/CALR/PIK3CD/TNF/HLA-E/APOBEC3H/TAP1/CALML3/GNB3/CXCR4/NFATC2/CALML6/ITPR1/CALML4/MAPK3/BCL2L1/AP1M1/IFNA7/CALML5/TNFRSF1A/GNG11/NFKBIA/AP1S2/GNAO1/GNAI3/APOBEC3D/BST2/HLA-F/TAP2/PAK1/RIPK1/PTK2/NFKB1/CCR5/LIMK2/AP1G2/FADD/IFNA8/NFATC1/BTRC/MAPK10/RAC1/AKT2/CASP8/MAPK12/HLA-B/PIK3R2/CD4/IRAK4/TRIM5/ITPR2/NRAS/TNFRSF1B/PLCG1/TRAF6/MAPK1/TRAF5/FBXW11/GNGT1/MAPK9/GNG4/MAP2K2/PIK3R1/HRAS/RAF1/CASP3/CALM1/B2M/PTK2B/MAP2K6/KRAS/CASP9/GNB4/CYCS/CFL1/ATM/CALM2/GNAQ/GNG2/PPP3R1/MAP2K1/CCNB3/PPP3CA/PAK4/BCL2/GNAI1/AP1S3/GNG7/TLR2/RPS6KB1/GNG8/RAC2/RELA/CFL2/SAMHD1/PPP3CC/LIMK1/PPP3CB/PIK3R3/AP1G1/IFNA4/IFNA14/PLCG2/WEE2/MAPK14/PAK2/TBK1/GNG3/PIK3CB/MAP2K3/APOBEC3C/RAC3/PXN/AP1M2/GNB1/GNG5/APOBEC3A/PPP3R2/FOS/TAPBP/MTOR/CALM3/IRF3/PAK3/GNG10/PRKCB/APOBEC3B/RNF7/BID/NFATC3	137
KEGG	hsa00600	Sphingolipid metabolism	35/5183	53/8144	0.4177	0.6643	0.5004	B4GALT5/SGMS1/GLB1/SGPL1/GALC/NEU2/SGMS2/SPTLC1/CERK/GBA/NEU4/SPTLC2/PSAP/ACER1/GAL3ST1/SPTLC3/NEU1/SMPD4/ENPP7/B4GALNT1/DEGS2/ASAH2/SMPD1/HEXA/SMPD3/SGPP1/DEGS1/NEU3/B4GALT6/ACER3/UGCG/HEXB/PSAPL1/UGT8/SMPD2	35
KEGG	hsa05110	Vibrio cholerae infection	33/5183	50/8144	0.4258	0.674	0.5077	ATP6V0E2/ACTB/ATP6V0A1/PRKACA/ATP6V0D2/KDELR2/ATP6V0A4/SEC61A1/ATP6V1B1/ATP6V1B2/ADCY3/ATP6V1C1/PLCG1/ATP6V1G3/ATP6V0D1/TJP1/ARF1/SEC61A2/SLC12A2/ATP6V1H/KDELR3/TJP2/KCNQ1/ATP6V1E1/SEC61B/ATP6V0E1/ATP6V1D/PRKACB/ATP6V1F/GNAS/PLCG2/TCIRG1/ACTG1	33
KEGG	hsa04727	GABAergic synapse	58/5183	89/8144	0.4284	0.6749	0.5083	GNGT2/GNB3/GABRR1/GNG11/SLC6A11/GNAO1/GNAI3/ADCY4/PRKACA/GABRA2/GLUL/CACNA1A/ADCY5/SLC32A1/GABRA4/PLCL1/GABRP/SLC12A5/GABRA1/SLC38A1/ADCY3/GABRD/GNGT1/CACNA1S/GABRA6/GLS/GNG4/ADCY6/NSF/GABBR2/ADCY2/GABRA5/ADCY8/GNB4/GABRG2/GABRR3/GABRA3/GAD2/GNG2/CACNA1B/GNAI1/ADCY7/GNG7/GNG8/GLS2/PRKACB/GABBR1/SLC6A13/GAD1/SLC6A1/GABRB2/GNG3/GNB1/GNG5/ADCY1/GNG10/PRKCB/KCNJ6	58
KEGG	hsa00480	Glutathione metabolism	38/5183	58/8144	0.4409	0.6887	0.5187	HPGDS/NAT8B/GSTT2B/PGD/LANCL1/GPX3/GSTA5/GSTP1/GSTA4/RRM2B/GSTT2/GPX6/NAT8/OPLAH/GSTM2/SRM/GGT7/GCLM/GSTA2/GSTA1/RRM2/ODC1/MGST1/GPX2/GGT6/MGST2/CHAC1/GSTM4/GPX5/GPX1/GSTK1/GPX8/GSTT1/GSTM3/LAP3/GSR/GGT1/IDH2	38
KEGG	hsa04931	Insulin resistance	70/5183	108/8144	0.4421	0.6887	0.5187	RPS6KB2/PIK3CD/PRKAA1/TNF/G6PC3/RPS6KA1/NR1H3/PRKAG1/PCK2/CREB3L2/PPARGC1B/PPP1R3D/PRKCD/SLC27A3/CREB3L4/TNFRSF1A/NFKBIA/STAT3/SREBF1/PTPRF/CD36/NFKB1/PTEN/INS/PCK1/PYGL/SLC2A1/PYGM/PRKAA2/GYS2/CREB5/MAPK10/PRKAG3/AKT2/TBC1D4/PIK3R2/MAPK9/PPP1R3A/G6PC/CRTC2/PIK3R1/SLC27A6/IRS2/CREB3L3/SLC27A4/SLC27A1/CREB3/IRS1/SLC27A2/PPP1R3C/PRKCZ/FOXO1/RPS6KB1/INSR/RELA/PYGB/SLC27A5/TRIB3/PIK3R3/RPS6KA2/PRKAG2/PIK3CB/NR1H2/MLXIPL/GYS1/MTOR/MLXIP/PRKCB/PRKCE/CREB1	70
KEGG	hsa00020	Citrate cycle (TCA cycle)	20/5183	30/8144	0.4454	0.6887	0.5187	PCK2/PC/IDH3A/PCK1/ACO1/CS/MDH2/OGDHL/SUCLG2/SUCLG1/DLD/ACO2/ACLY/PDHB/FH/DLAT/SDHA/SDHB/IDH2/SDHC	20
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	20/5183	30/8144	0.4454	0.6887	0.5187	AMT/ACSS1/HAO1/GLUL/HAO2/ACAT1/GRHPR/ACO1/CS/ACSS2/SHMT1/MDH2/DLD/ACO2/GLDC/GLYCTK/PCCB/SHMT2/PGP/GCSH	20
KEGG	hsa00983	Drug metabolism - other enzymes	52/5183	80/8144	0.4497	0.6921	0.5213	NME4/MPO/GSTT2B/UCK2/CYP3A4/CDA/UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/GSTA5/NAT2/UGT1A3/GSTP1/GSTA4/RRM2B/GSTT2/GSTM2/IMPDH1/UGT2B7/UGT1A1/TYMP/NME1/UPB1/UGT2B11/UCKL1/CYP2A7/GSTA2/UGT2A3/GSTA1/RRM2/UGT2B10/NAT1/MGST1/DPYD/IMPDH2/MGST2/UCK1/NME2/NME7/GSTM4/UGT2B15/NME3/GSTT1/GSTM3/TK1/UGT2A1/UPP2/NME1-NME2	52
KEGG	hsa05330	Allograft rejection	25/5183	38/8144	0.4636	0.7103	0.535	FASLG/PRF1/CD28/GZMB/IL10/TNF/HLA-E/IFNG/IL5/IL2/HLA-DMB/HLA-F/IL4/HLA-DOA/IL12B/HLA-B/HLA-DQA1/CD40/HLA-DRA/HLA-DQA2/HLA-DPB1/HLA-DOB/HLA-DMA/CD80/CD40LG	25
KEGG	hsa00920	Sulfur metabolism	7/5183	10/8144	0.4771	0.7258	0.5467	SUOX/SELENBP1/PAPSS1/IMPAD1/ETHE1/PAPSS2/TST	7
KEGG	hsa04930	Type II diabetes mellitus	30/5183	46/8144	0.4781	0.7258	0.5467	PIK3CD/TNF/SOCS2/MAPK3/PRKCD/CACNA1G/GCK/PDX1/INS/CACNA1A/CACNA1E/MAPK10/PIK3R2/HKDC1/MAFA/MAPK1/MAPK9/PIK3R1/HK3/IRS2/IRS1/CACNA1B/PRKCZ/INSR/HK1/SOCS1/PIK3R3/PIK3CB/MTOR/PRKCE	30
KEGG	hsa00860	Porphyrin metabolism	28/5183	43/8144	0.4888	0.7387	0.5564	BLVRA/CPOX/UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/UGT1A3/HMBS/ALAS1/UGT2B7/UGT1A1/UGT2B11/HMOX1/CP/EARS2/UGT2A3/HMOX2/UGT2B10/UROD/ALAD/UGT2B15/HEPHL1/UGT2A1/BLVRB/COX10	28
KEGG	hsa00270	Cysteine and methionine metabolism	33/5183	51/8144	0.5003	0.7527	0.567	PSAT1/DNMT1/AHCYL1/DNMT3B/APIP/AHCYL2/GOT1L1/SRM/GCLM/AGXT2/MAT1A/MDH2/LDHAL6B/TAT/PHGDH/ADI1/AHCY/DNMT3A/MAT2A/SDSL/BHMT2/BCAT1/LDHA/LDHB/SDS/GOT1/CBS/CDO1/ENOPH1/MTAP/TST/AMD1/LDHC	33
KEGG	hsa05143	African trypanosomiasis	24/5183	37/8144	0.5127	0.7679	0.5784	FASLG/IL1B/IL10/F2RL1/TNF/IFNG/IL18/IDO2/SELE/KNG1/IL12B/LAMA4/ICAM1/THOP1/HBB/HBA1/PLCB1/GNAQ/PLCB4/TLR9/PLCB2/PLCB3/APOA1/PRKCB	24
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	10/5183	15/8144	0.5199	0.7751	0.5839	FUT1/B3GALNT1/GBGT1/FUT9/B3GALT5/A4GALT/ST8SIA1/HEXA/NAGA/HEXB	10
KEGG	hsa03060	Protein export	15/5183	23/8144	0.5317	0.7857	0.5918	SRP68/SEC61A1/SEC63/SEC11C/IMMP2L/SEC61A2/SRP72/SEC11A/SEC61B/OXA1L/SRP19/SRPRB/HSPA5/SPCS1/SPCS3	15
KEGG	hsa04614	Renin-angiotensin system	15/5183	23/8144	0.5317	0.7857	0.5918	CTSG/CTSA/KLK2/MRGPRD/ACE/LNPEP/CPA3/MAS1/MME/THOP1/KLK1/AGTR2/ACE2/AGTR1/NLN	15
KEGG	hsa05332	Graft-versus-host disease	27/5183	42/8144	0.5352	0.7874	0.5931	FASLG/PRF1/CD28/GZMB/KLRD1/IL1B/TNF/HLA-E/IFNG/KIR3DL2/KIR3DL1/IL2/HLA-DMB/KIR2DL1/KLRC1/HLA-F/KIR2DL3/HLA-DOA/HLA-B/HLA-DQA1/HLA-DRA/KIR3DL3/HLA-DQA2/HLA-DPB1/HLA-DOB/HLA-DMA/CD80	27
KEGG	hsa05323	Rheumatoid arthritis	59/5183	93/8144	0.5629	0.8225	0.6195	TLR4/CD28/ITGAL/TNFSF13/IL1B/TNF/LTB/IFNG/IL18/ATP6V0E2/CCL5/HLA-DMB/CXCL1/TNFSF13B/CXCL2/ATP6V0A1/IL17A/IL23A/CTLA4/CXCL6/ATP6V0D2/MMP1/HLA-DOA/CCL20/CTSK/ATP6V0A4/ATP6V1B1/ATP6V1B2/ITGB2/MMP3/CSF2/HLA-DQA1/ATP6V1C1/HLA-DRA/ATP6V1G3/ICAM1/IL15/CXCL3/ATP6V0D1/ACP5/ATP6V1H/TGFB2/CCL3/HLA-DQA2/TLR2/HLA-DPB1/HLA-DOB/ATP6V1E1/ATP6V0E1/ATP6V1D/HLA-DMA/ATP6V1F/CD80/TCIRG1/CCL2/CCL3L1/CCL3L3/FOS/TEK	59
KEGG	hsa04936	Alcoholic liver disease	90/5183	142/8144	0.5639	0.8225	0.6195	FASLG/TLR4/TCF7/IL1B/PRKAA1/TNF/LBP/IKBKE/IL17RC/PRKAG1/C1QB/ADIPOR2/CXCL1/LEF1/IFNA7/CXCL2/IL17A/TNFRSF1A/C1QA/SCD5/NFKBIA/C3AR1/C5AR1/SREBF1/RIPK1/NFKB1/ALDH2/C2/TCF7L1/TRA2B/FOXO3/PRKAA2/FADD/IFNA8/ADH6/IL12B/LPIN1/CAMKK2/MAPK10/NOX4/PRKAG3/ADH7/AKT2/C4A/C4B/FABP1/CASP8/MAPK12/IRAK4/MAP3K14/MAP3K5/TRAF6/ADH1C/CXCL3/C5/ALDH3A2/MAPK9/ACOX3/C1QC/ADIPOR1/FASN/CASP3/MAP2K4/MAP2K6/ADH1B/TICAM1/LY96/ALDH7A1/TIRAP/FOXO1/CD14/RELA/CPT1C/CTNNB1/ACACA/C3/TCF7L2/ADH5/PRKAG2/IFNA4/IFNA14/MAPK14/TBK1/ALDH9A1/MAP2K3/SCD/LPIN3/TRAF3/IRF3/ADH4	90
KEGG	hsa01523	Antifolate resistance	19/5183	30/8144	0.5953	0.8588	0.6469	FPGS/IL1B/FOLR3/TNF/ABCC1/FOLR1/NFKB1/SLC19A1/DHFR/GGH/ALOX12/SHMT1/MTHFR/ABCC3/FOLR2/RELA/ABCC5/SHMT2/ABCC2	19
KEGG	hsa05160	Hepatitis C	99/5183	157/8144	0.5965	0.8588	0.6469	FASLG/PIK3CD/TNF/YWHAG/IFNG/E2F1/IKBKE/CLDN15/NR1H3/CLDN22/JAK1/CLDN18/CLDN16/MAPK3/IFNA7/CD81/TNFRSF1A/RXRA/CLDN1/CLDN19/NFKBIA/PPP2R2C/STAT3/CLDN14/CDKN1A/CLDN17/IFIT1/GRB2/RIPK1/TP53/NFKB1/YWHAZ/RSAD2/OAS2/CLDN11/CLDN7/FADD/IFNA8/CXCL10/AKT2/CASP8/PIK3R2/CDK6/NRAS/TRAF6/MAPK1/PPP2R2A/LDLR/IRF9/PPP2R2D/MAP2K2/PIK3R1/HRAS/RAF1/PSME3/EGFR/RNASEL/CASP3/KRAS/CASP9/CLDN25/CFLAR/CYCS/E2F3/TICAM1/PPP2CB/CLDN6/MAP2K1/MAVS/EGF/CLDN9/STAT1/CDK2/EIF2AK2/EIF2AK3/CLDN3/RELA/CTNNB1/PIK3R3/PPP2R1A/EIF2AK4/IFNA4/IFNA14/SOS2/TBK1/E2F2/PIK3CB/OAS1/CLDN20/TRAF3/PPP2CA/IFNAR2/MX2/BRAF/IRF3/RB1/BID/SCARB1/SOS1	99
KEGG	hsa04115	p53 signaling pathway	46/5183	73/8144	0.5965	0.8588	0.6469	SERPINB5/BCL2L1/RRM2B/TP53AIP1/GADD45G/CCND2/CDKN1A/TP53/PTEN/AIFM2/RCHY1/CDKN2A/RPRM/CASP8/CDK6/IGFBP3/TP53I3/SESN2/TSC2/RRM2/TNFRSF10A/CASP3/CASP9/CYCS/MDM2/TP73/SFN/SERPINE1/ATM/BCL2/CCNG2/CDK2/PMAIP1/SIAH1/CCND3/PERP/GADD45A/CHEK2/SHISA5/BBC3/MDM4/CCNE1/GORAB/ZMAT3/BID/TNFRSF10B	46
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	9/5183	14/8144	0.5991	0.8588	0.6469	B3GNT2/B4GALT1/FUT8/ST3GAL3/CHST4/B4GALT3/CHST6/B3GNT7/CHST1	9
KEGG	hsa00330	Arginine and proline metabolism	32/5183	51/8144	0.6146	0.8754	0.6594	GAMT/PRODH/CKMT2/ARG1/PYCR2/AGMAT/P4HA2/SMOX/ARG2/GOT1L1/CKMT1A/ALDH2/SRM/SAT2/CKM/PRODH2/DAO/OAT/ALDH3A2/ODC1/CKMT1B/CKB/ALDH7A1/NOS2/GOT1/P4HA3/ALDH9A1/LAP3/ALDH4A1/NOS1/GATM/AMD1	32
KEGG	hsa04330	Notch signaling pathway	37/5183	59/8144	0.6163	0.8754	0.6594	PTCRA/APH1A/MAML1/APH1B/JAG2/HES5/HEYL/ATXN1/CTBP2/NOTCH4/NCOR2/EP300/HES1/HEY1/CTBP1/NUMB/HDAC1/DTX3/DLL3/MFNG/DVL1/PSENEN/ADAM17/MAML2/TLE3/DLL4/NOTCH2/TLE1/CREBBP/HDAC2/RFNG/DTX2/DVL3/DTX3L/ATXN1L/KAT2B/PSEN1	37
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	12/5183	19/8144	0.6186	0.8754	0.6594	GOT1L1/IDH3A/ACO1/GPT/CS/GPT2/AADAT/ACO2/BCAT1/GOT1/IDH2/NAGS	12
KEGG	hsa05169	Epstein-Barr virus infection	127/5183	202/8144	0.6218	0.8764	0.6601	CD247/CD3D/CD3G/RUNX3/CD3E/CALR/ITGAL/PIK3CD/TNF/HLA-E/E2F1/IKBKE/TAP1/JAK1/SYK/HLA-DMB/IFNA7/ENTPD1/GADD45G/CCND2/NFKBIA/STAT3/CDKN1A/CD19/HLA-F/TAP2/RIPK1/TP53/NFKB1/OAS2/HLA-DOA/CD44/FADD/IFNA8/CCNA1/CXCL10/MAPK10/RAC1/AKT2/PSMD13/NCOR2/CASP8/MAPK12/HLA-B/PIK3R2/CDK6/IRAK4/HES1/MAP3K14/HLA-DQA1/PSMC2/CD40/HLA-DRA/TRAF6/TRAF5/ICAM1/ENTPD8/PSMD1/IRF9/LYN/MAPK9/HDAC1/PIK3R1/ISG15/PSMC6/CASP3/B2M/MAP2K4/MAP2K6/CASP9/CYCS/MDM2/E2F3/NFKBIB/FCER2/PSMC4/HLA-DQA2/TNFAIP3/PSMD2/CR2/VIM/CD58/MAVS/PSMC5/BCL2/USP7/TLR2/STAT1/NFKBIE/CDK2/EIF2AK2/PSMD14/BCL2L11/CCND3/HLA-DPB1/RELA/HLA-DOB/HLA-DMA/PIK3R3/GADD45A/IFNA4/PSMD8/IFNA14/PLCG2/MAPK14/NFKB2/TBK1/PSMD7/E2F2/PIK3CB/MAP2K3/SIN3A/OAS1/PSMD12/HDAC2/SAP30/CCNE1/PSMD6/TAPBP/TRAF3/IFNAR2/POLK/IRF3/CDKN1B/RB1/RELB/BID	127
KEGG	hsa00230	Purine metabolism	80/5183	128/8144	0.6444	0.9043	0.6812	NME4/AK2/PDE7A/AMPD3/PDE6C/PDE6H/NPR2/PDE8A/RRM2B/ENTPD1/PDE11A/PGM1/CANT1/ADCY4/ENTPD4/IMPDH1/PDE6B/ADCY5/FHIT/PDE9A/HDDC2/ENPP3/PDE8B/PDE1A/GUCY2C/GUCY2D/NME1/GUK1/AK3/PDE3B/AMPD1/NT5C1A/ADSL/APRT/ADCY3/AK1/ENTPD8/ADA/PAPSS1/RRM2/ADCY6/GMPR/HDDC3/PDE2A/ADCY2/PDE6G/AMPD2/PDE1B/ADCY8/ENTPD6/NPR1/AK5/NT5C2/DCK/ADCY7/PDE6D/IMPDH2/NT5M/PRPS1L1/PPAT/ADK/NME2/NME7/ENPP1/NME3/ENTPD2/PAPSS2/NUDT16/PGM2/PDE4B/PDE5A/NUDT9/AK7/ADCY1/PAICS/GDA/GUCY1A2/NT5E/NME1-NME2/ENPP4	80
KEGG	hsa04392	Hippo signaling pathway - multiple species	18/5183	29/8144	0.6495	0.9077	0.6837	CSNK1E/FRMD6/WWC1/PAK1/STK3/LIMD1/FRMD1/TEAD1/TEAD2/RASSF4/RASSF6/FAT4/SAV1/TEAD3/LATS2/DCHS1/LATS1/DCHS2	18
KEGG	hsa00564	Glycerophospholipid metabolism	61/5183	98/8144	0.6564	0.9128	0.6875	DGKA/CHKA/GPD2/PLA2G2D/PNPLA7/DGKB/PLA2G4A/PLA2G2F/PLD3/MBOAT2/PLA2G1B/PLB1/AGPAT2/DGKZ/PLA2G4E/PCYT2/PLA2G4D/DGKI/LPIN1/MBOAT1/PTDSS1/PLA2G2E/GPAT2/PLD1/MBOAT7/PLA2G2C/PLA2G2A/CHAT/PLA2G4C/GPD1/PLA2G10/PLA2G5/PLA2G6/CDS2/PLA2G12A/AGPAT4/LPGAT1/PLA2G3/PLD2/PLA2G12B/CHPT1/DGKQ/PHOSPHO1/AGPAT5/DGKD/LYPLA1/LCAT/CDS1/DGKE/DGKH/GPD1L/PCYT1A/ETNK1/PLA2G4F/ACHE/CHKB/CEPT1/PTDSS2/LPIN3/GPAM/LPCAT2	61
KEGG	hsa04621	NOD-like receptor signaling pathway	115/5183	184/8144	0.6586	0.9128	0.6875	TLR4/IL1B/TNF/VDAC2/TRIP6/RIPK2/IL18/IKBKE/PYCARD/NLRC4/CARD18/CCL5/DEFA4/NLRP3/JAK1/NLRP1/ITPR1/MAPK3/BCL2L1/PRKCD/NOD1/NAIP/CXCL1/IFNA7/CXCL2/IFI16/NOD2/NFKBIA/RIPK1/NFKB1/CASP1/OAS2/AIM2/NLRP7/CASP5/GBP2/FADD/CASR/NLRX1/IFNA8/DEFA6/BIRC2/MAPK10/GBP1/CASP8/MAPK12/PKN1/CASP4/IRAK4/P2RX7/TRPM2/ITPR2/TRAF6/MAPK1/TRAF5/CXCL3/SHARPIN/IRF9/MAPK9/GBP3/GSDMD/CARD16/MAP1LC3B/PYDC1/RNASEL/CARD8/HSP90AA1/NEK7/CTSB/PSTPIP1/PLCB1/NFKBIB/TICAM1/NLRP12/RNF31/BIRC3/TNFAIP3/RBCK1/MAP1LC3A/CYBA/MAVS/BCL2/TXN2/STAT1/PLCB4/DHX33/ANTXR2/RELA/PLCB2/ANTXR1/DEFA5/GBP4/ATG5/CARD6/PLCB3/IFNA4/IFNA14/TRPV2/MAPK14/GBP7/ATG16L1/TBK1/MEFV/NLRP6/CCL2/OAS1/HSP90AB1/TRAF3/GPRC6A/DEFA1/DEFA1B/IFNAR2/IRF3/CAMP/MAP1LC3B2	115
KEGG	hsa00790	Folate biosynthesis	16/5183	26/8144	0.6706	0.9256	0.6972	FPGS/TH/TPH2/TPH1/DHFR/AKR1B10/QDPR/ALPI/GGH/SPR/MOCS2/ALPP/PTS/MOCS1/PCBD2/AKR1C3	16
KEGG	hsa04710	Circadian rhythm	19/5183	31/8144	0.6816	0.9369	0.7057	PRKAA1/RORA/CSNK1E/PRKAG1/CLOCK/PER1/RORC/BHLHE40/CRY2/PRKAA2/BTRC/PRKAG3/FBXW11/PER3/RORB/CRY1/PRKAG2/FBXL3/CREB1	19
KEGG	hsa00512	Mucin type O-glycan biosynthesis	22/5183	36/8144	0.6919	0.9463	0.7128	ST6GALNAC1/B4GALT5/GALNT5/GALNT3/GALNT9/GALNT12/ST6GALNAC2/GCNT4/GALNT13/ST6GALNAC4/GALNT8/ST6GALNAC3/GALNT10/GALNT1/GALNT6/GALNTL5/C1GALT1/GCNT3/GALNT11/GALNT4/GALNTL6/GALNT7	22
KEGG	hsa03430	Mismatch repair	14/5183	23/8144	0.6941	0.9463	0.7128	MSH6/RPA3/RPA1/RFC5/MSH3/MSH2/PMS2/RPA2/RFC3/POLD4/MLH3/POLD3/LIG1/PCNA	14
KEGG	hsa01200	Carbon metabolism	71/5183	115/8144	0.7022	0.9534	0.7182	PSAT1/FBP2/AMT/PGK2/PGD/FBP1/TKT/ME3/TKTL2/ALDOB/ACSS1/GCK/PC/GOT1L1/HAO1/IDH3A/H6PD/CPS1/HAO2/ALDOC/ACAT1/ACO1/GPT/CS/GPT2/ENO1/ACSS2/SHMT1/HKDC1/MDH2/OGDHL/PHGDH/ACOX3/TPI1/ME1/SUCLG2/SUCLG1/GPI/HK3/ESD/ADPGK/GAPDH/DLD/ACO2/SDSL/ALDH6A1/ENO3/GLUD1/PDHB/HK1/PRPS1L1/SDS/GOT1/FH/ADH5/PGAM4/GLDC/GLYCTK/PSPH/DLAT/ME2/PCCB/SDHA/SDHB/SHMT2/RPE/PGP/GCSH/PGAM2/IDH2/SDHC	71
KEGG	hsa04130	SNARE interactions in vesicular transport	20/5183	33/8144	0.7107	0.961	0.7238	STX5/STX1A/STX18/SNAP23/GOSR1/STX2/VTI1A/STX11/VAMP3/VAMP8/YKT6/STX6/STX1B/STX4/STX19/STX16/GOSR2/STX3/VAMP1/STX7	20
KEGG	hsa04137	Mitophagy - animal	44/5183	72/8144	0.7185	0.9677	0.7289	E2F1/MITF/BCL2L1/SQSTM1/TAX1BP1/TP53/NBR1/HIF1A/FOXO3/SP1/MAPK10/UBB/NRAS/MAPK9/RRAS/HRAS/MAP1LC3B/TBC1D15/KRAS/TBC1D17/BCL2L13/UBC/OPTN/CSNK2A1/USP8/MAP1LC3A/CALCOCO2/CSNK2B/TFEB/EIF2AK3/CSNK2A2/RELA/AMBRA1/PINK1/TOMM7/ATG5/CITED2/TBK1/ATG9B/RHOT2/USP15/ATF4/MAP1LC3B2/BNIP3L	44
KEGG	hsa04920	Adipocytokine signaling pathway	42/5183	69/8144	0.7301	0.9794	0.7377	PRKAA1/TNF/G6PC3/PRKAG1/PCK2/ADIPOR2/TNFRSF1A/RXRA/ACSBG1/NFKBIA/STAT3/CD36/NFKB1/PCK1/SLC2A1/PRKAA2/ACSL3/CAMKK2/MAPK10/PRKAG3/AKT2/RXRG/TNFRSF1B/ACSBG2/MAPK9/G6PC/LEP/LEPR/ADIPOR1/IRS2/NFKBIB/IRS1/NFKBIE/STK11/RELA/CPT1C/POMC/PRKAG2/ACSL5/MTOR/RXRB/NPY	42
KEGG	hsa00561	Glycerolipid metabolism	37/5183	61/8144	0.7347	0.9816	0.7394	DGKA/PNPLA2/MOGAT2/PNLIP/DGAT1/GK2/DGKB/PNLIPRP3/MBOAT2/AGPAT2/CEL/DGKZ/AKR1B10/ALDH2/DGKI/LPIN1/MBOAT1/GPAT2/LIPF/ALDH3A2/PNPLA3/MOGAT1/AGPAT4/PNLIPRP1/ALDH7A1/DGKQ/AGK/AGPAT5/DGKD/DGKE/DGKH/GLYCTK/ALDH9A1/DGAT2/LPIN3/LIPC/GPAM	37
KEGG	hsa00240	Pyrimidine metabolism	35/5183	58/8144	0.7477	0.995	0.7494	NME4/UCK2/CDA/DHODH/RRM2B/ENTPD1/CMPK2/CANT1/ENTPD4/HDDC2/ENPP3/TYMP/NME1/UPB1/UCKL1/NT5C1A/ENTPD8/RRM2/ENTPD6/DCTPP1/NT5C2/DPYD/DCK/DCTD/NT5M/UCK1/NME2/NME7/ENPP1/NME3/TK1/NT5E/UPP2/NME1-NME2/CTPS2	35
KEGG	hsa03250	Viral life cycle - HIV-1	38/5183	63/8144	0.7543	0.9986	0.7522	APOBEC3H/CXCR4/MAP1A/HGS/APOBEC3D/BST2/MLLT3/CCR5/AFF4/SMARCB1/CD4/EP300/TRIM5/SUPT4H1/FEZ1/FURIN/CHMP4A/MLLT1/RANBP2/PIN1/SAMHD1/CCNT1/ELL2/RAN/CREBBP/APOBEC3C/ELL/PDCD6IP/APOBEC3A/MX2/APOBEC3B/CHMP4B/ELL3/KAT2B/XPO1/SERINC3/VPS4A/SERINC5	38
KEGG	hsa04215	Apoptosis - multiple species	19/5183	32/8144	0.7564	0.9986	0.7522	DIABLO/BCL2L1/TNFRSF1A/NGFR/FADD/BIRC2/MAPK10/CASP8/MAPK9/CASP3/CASP9/CYCS/BIRC7/BIRC3/BCL2/PMAIP1/BCL2L11/BBC3/BID	19
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	22/5183	37/8144	0.7607	1	0.7532	ASPA/GOT1L1/RIMKLB/GLUL/CPS1/GPT/GPT2/AGXT2/ADSL/GLS/GAD2/GLUD1/ALDH5A1/PPAT/RIMKLA/GLS2/GOT1/ASNS/GAD1/ASRGL1/ALDH4A1/ASS1	22
KEGG	hsa00380	Tryptophan metabolism	25/5183	42/8144	0.7653	1	0.7532	DDC/IDO2/CYP1A2/TPH2/TPH1/ALDH2/AANAT/INMT/ACAT1/AOX1/KYNU/DHTKD1/AADAT/ALDH3A2/TDO2/ALDH8A1/ALDH7A1/HAAO/DLD/GCDH/HADH/ALDH9A1/CYP1A1/ACMSD/CYP1B1	25
KEGG	hsa01232	Nucleotide metabolism	51/5183	85/8144	0.7934	1	0.7532	NME4/AK2/AMPD3/UCK2/CDA/RRM2B/ENTPD1/CMPK2/CANT1/ENTPD4/IMPDH1/HDDC2/ENPP3/TYMP/NME1/GUK1/AK3/UCKL1/AMPD1/NT5C1A/ADSL/APRT/AK1/ENTPD8/ADA/RRM2/GMPR/AMPD2/ENTPD6/DCTPP1/AK5/NT5C2/DCK/DCTD/IMPDH2/NT5M/UCK1/ADK/NME2/NME7/ENPP1/NME3/ENTPD2/NUDT16/TK1/AK7/GDA/NT5E/UPP2/NME1-NME2/CTPS2	51
KEGG	hsa01240	Biosynthesis of cofactors	93/5183	153/8144	0.7964	1	0.7532	NME4/PSAT1/FPGS/AK2/CPOX/IDO2/UGT1A5/UGT1A7/UGT1A6/UGT1A9/UGT1A10/UGT1A8/UGT1A4/NMNAT2/UGT1A3/DHODH/MTHFD1/HMBS/RDH12/NFS1/PPCDC/CMPK2/HPD/ALAS1/DHFR/ALDH2/UGT2B7/ALPI/MPI/GGH/UGT1A1/KYNU/GGCX/GCLM/NME1/MTHFD1L/UGT2B11/AK3/SPR/SHMT1/MAT1A/PDXK/MOCS2/GMPPB/ADSL/AK1/EARS2/FLAD1/ALDH3A2/UGT2A3/ALPP/TDO2/OXSM/QPRT/UGT2B10/NADK/UROD/ALAD/PANK3/HAAO/DLD/AK5/UGDH/MAT2A/NQO1/PANK2/UGP2/PTS/BCAT1/NADSYN1/GMPPA/MTHFD2L/NME2/NME7/UGT2B15/LIPT1/COASY/NME3/VKORC1L1/RDH13/COQ7/PPCS/SHMT2/PDXP/MOCS1/NMNAT3/AK7/UGT2A1/PANK1/COX10/PMM2/NME1-NME2/CTPS2	93
KEGG	hsa05100	Bacterial invasion of epithelial cells	46/5183	77/8144	0.7988	1	0.7532	PIK3CD/SHC1/CBL/ITGA5/ELMO1/ACTB/CAV3/VCL/CDC42/CD2AP/DNM1/CTNNA3/PTK2/SHC2/GAB1/RAC1/SHC4/MET/PIK3R2/CTNNA1/CLTA/DNM3/CDH1/PIK3R1/ARPC4/CAV1/BCAR1/CLTC/RHOG/ITGB1/CTNNA2/ELMO3/CTNNB1/PIK3R3/MAD2L2/ACTR3C/PIK3CB/PXN/ACTR2/ELMO2/FN1/ARPC5L/ACTR3B/DNM2/CAV2/ACTG1	46
KEGG	hsa03050	Proteasome	27/5183	46/8144	0.8042	1	0.7532	IFNG/PSMB8/PSMB11/PSMD13/PSMB7/PSMB9/PSMC2/PSMD1/POMP/PSME3/PSMC6/PSMB4/PSMB10/PSMC4/PSMD2/PSMA4/PSMC5/PSMD14/PSMB5/PSMB2/PSMD8/PSMB6/PSME2/PSMD7/PSMD12/PSMF1/PSMD6	27
KEGG	hsa04260	Cardiac muscle contraction	52/5183	87/8144	0.8076	1	0.7532	ATP1A2/MYH6/MYH7/FXYD2/CACNG1/CACNA2D3/CACNG5/MYL4/ATP1A1/TRDN/TNNT2/SLC8A1/COX6B2/ATP2A1/CACNG8/COX7B2/ATP1B1/TNNC1/CACNA2D1/UQCRFS1/COX8C/CACNA1S/COX4I2/SLC9A1/MYL2/ATP1A4/CACNG4/CASQ2/COX7A1/TPM3/RYR2/COX6A1/COX6C/HRC/COX6B1/CACNB1/UQCRQ/SLC8A3/SLC8A2/CACNG6/CACNA2D2/CACNB4/CYC1/COX6A2/UQCRHL/CACNG2/ATP1B2/COX5A/ATP1A3/MYL3/TPM4/CACNG7	52
KEGG	hsa00360	Phenylalanine metabolism	9/5183	16/8144	0.8107	1	0.7532	DDC/ALDH3B1/ALDH3B2/AOC3/AOC2/HPD/GOT1L1/TAT/GOT1	9
KEGG	hsa05162	Measles	84/5183	139/8144	0.8117	1	0.7532	FASLG/CD3D/IL2RB/CD3G/TLR4/CD28/CD3E/PIK3CD/IL1B/IKBKE/CLEC4M/JAK1/STAT5A/BCL2L1/IL2/IFNA7/CCND2/HSPA8/NFKBIA/STAT3/TP53/NFKB1/RCHY1/OAS2/FADD/IFNA8/IL12B/IL2RA/MAPK10/AKT2/CASP8/PIK3R2/CDK6/IRAK4/TRAF6/IRF9/CD46/MAPK9/PIK3R1/CASP3/CASP9/CD209/CYCS/TP73/NFKBIB/EIF3H/CSNK2A1/TNFAIP3/HSPA1A/MAVS/HSPA2/CSNK2B/BCL2/HSPA1L/TLR2/STAT1/CDK2/EIF2AK2/EIF2AK3/TLR9/CBLB/CSNK2A2/CCND3/RELA/PIK3R3/EIF2AK4/IFNA4/IFNA14/TBK1/PIK3CB/OAS1/TLR7/BBC3/CCNE1/STAT5B/FOS/TRAF3/IFNAR2/MX2/IRF3/CDKN1B/IL2RG/BID/RAB9A	84
KEGG	hsa00650	Butanoate metabolism	16/5183	28/8144	0.8201	1	0.7532	ACSM5/ACSM1/ACSM4/HMGCS2/HMGCLL1/BDH1/ACAT1/AACS/OXCT1/GAD2/HMGCL/OXCT2/ALDH5A1/HADH/GAD1/ACSM3	16
KEGG	hsa00280	Valine, leucine and isoleucine degradation	28/5183	48/8144	0.8211	1	0.7532	ACAD8/BCKDHB/BCKDHA/HMGCS2/HMGCLL1/ALDH2/ACAT1/AOX1/ACSF3/AGXT2/AACS/OXCT1/ALDH3A2/AUH/ALDH7A1/DLD/DBT/HIBADH/ALDH6A1/HMGCL/ACAA2/BCAT1/OXCT2/HADH/ALDH9A1/PCCB/MCCC2/MCCC1	28
KEGG	hsa05320	Autoimmune thyroid disease	31/5183	53/8144	0.8231	1	0.7532	FASLG/PRF1/CD28/GZMB/IL10/HLA-E/IL5/IL2/HLA-DMB/IFNA7/CTLA4/HLA-F/IL4/HLA-DOA/IFNA8/HLA-B/TPO/HLA-DQA1/CD40/HLA-DRA/HLA-DQA2/CGA/HLA-DPB1/HLA-DOB/HLA-DMA/TG/IFNA4/CD80/IFNA14/CD40LG/TSHB	31
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/5183	11/8144	0.8275	1	0.7532	HPD/GGCX/TAT/NQO1/VKORC1L1/COQ7	6
KEGG	hsa05164	Influenza A	103/5183	171/8144	0.8453	1	0.7532	FASLG/TLR4/PIK3CD/IL1B/TNF/IFNG/IL18/IFNGR2/IKBKE/PYCARD/CCL5/ACTB/NLRP3/JAK1/NXF1/MAPK3/HLA-DMB/IFNA7/TNFRSF1A/TNFSF10/NFKBIA/PABPN1L/SLC25A31/TMPRSS2/FDPS/NFKB1/TPSD1/TMPRSS4/CASP1/RSAD2/OAS2/HLA-DOA/HNRNPUL1/FADD/PLG/NLRX1/IFNA8/IL12B/CXCL10/AKT2/TPSAB1/CASP8/PIK3R2/CDK6/IRAK4/EP300/DNAJB1/HLA-DQA1/HLA-DRA/CIITA/MAPK1/KPNA7/ICAM1/IRF9/MAP2K2/PIK3R1/RAF1/TNFRSF10A/RNASEL/CASP3/TPSB2/CASP9/CYCS/TMPRSS11D/NFKBIB/TICAM1/HLA-DQA2/MAP2K1/PRSS1/MAVS/CALCOCO2/IL33/STAT1/EIF2AK2/TRIM25/CCND3/HLA-DPB1/RELA/HLA-DOB/HLA-DMA/PIK3R3/RAB11B/IFNA4/IFNA14/KPNA6/CREBBP/TBK1/PIK3CB/CCL2/OAS1/TLR7/TRAF3/CPSF4/IFNAR2/MX2/RAB11A/IRF3/PRKCB/BID/TNFRSF10B/XPO1/CPSF4L/ACTG1	103
KEGG	hsa00670	One carbon pool by folate	11/5183	20/8144	0.85	1	0.7532	AMT/MTHFD1/DHFR/FTCD/MTHFD1L/SHMT1/ALDH1L2/MTHFR/ALDH1L1/MTHFD2L/SHMT2	11
KEGG	hsa05161	Hepatitis B	97/5183	162/8144	0.8616	1	0.7532	FASLG/TLR4/PIK3CD/TNF/E2F1/IKBKE/EGR3/SLC10A1/JAK1/CREB3L2/NFATC2/CASP10/STAT5A/MAPK3/CREB3L4/IFNA7/MMP9/NFKBIA/STAT3/CDKN1A/TICAM2/TGFBR2/GRB2/TP53/NFKB1/YWHAZ/HSPG2/CREB5/FADD/IFNA8/NFATC1/CCNA1/MAPK10/AKT2/CASP8/MAPK12/PIK3R2/IRAK4/EP300/NRAS/TRAF6/MAPK1/MAPK9/MAP2K2/PIK3R1/HRAS/RAF1/ATF2/CASP3/STAT6/MAP2K4/PTK2B/CREB3L3/MAP2K6/KRAS/CASP9/CYCS/TGFB2/E2F3/TICAM1/MAP3K1/CREB3/TIRAP/MAP2K1/MAVS/BCL2/TLR2/STAT1/CDK2/RELA/PIK3R3/TGFBR1/IFNA4/SMAD4/IFNA14/MAPK14/CREBBP/SOS2/TBK1/E2F2/PIK3CB/MAP2K3/CCNE1/STAT5B/FOS/SMAD3/TRAF3/PCNA/BRAF/IRF3/PRKCB/RB1/BID/NFATC3/SOS1/ATF4/CREB1	97
KEGG	hsa00730	Thiamine metabolism	8/5183	15/8144	0.8635	1	0.7532	AK2/NFS1/ALPI/AK1/ALPP/AK5/THTPA/AK7	8
KEGG	hsa00340	Histidine metabolism	12/5183	22/8144	0.8659	1	0.7532	ALDH3B1/ALDH3B2/ASPA/HAL/HNMT/ALDH2/FTCD/UROC1/ALDH3A2/ALDH7A1/ALDH9A1/AMDHD1	12
KEGG	hsa03020	RNA polymerase	19/5183	34/8144	0.8683	1	0.7532	POLR2L/POLR2E/POLR1B/POLR2B/CD3EAP/POLR2K/POLR1A/POLR2A/POLR2F/POLR2G/POLR3D/POLR3H/POLR3GL/POLR3A/POLR2D/POLR1E/POLR1D/POLR2H/POLR2J2	19
KEGG	hsa04914	Progesterone-mediated oocyte maturation	60/5183	102/8144	0.8686	1	0.7532	PIK3CD/RPS6KA1/MAPK3/SPDYE4/CDC25B/GNAI3/CPEB2/ADCY4/PRKACA/INS/ADCY5/AURKA/CCNA1/MAPK10/AKT2/MAPK12/PIK3R2/ANAPC10/PDE3B/SPDYE5/MAD2L1/SPDYC/FZR1/ADCY3/MAPK1/PKMYT1/CDC26/SPDYE1/MAPK9/PIK3R1/RAF1/ADCY6/KIF22/HSP90AA1/ADCY2/KRAS/ADCY8/MAP2K1/CCNB3/CDC16/GNAI1/ADCY7/CDK2/IGF1R/CPEB1/PGR/PRKACB/PIK3R3/RPS6KA2/MAD2L2/SPDYE3/MAPK14/PLK1/PIK3CB/HSP90AB1/ADCY1/BRAF/MAD1L1/ANAPC11/ANAPC2	60
KEGG	hsa04216	Ferroptosis	23/5183	41/8144	0.8781	1	0.7532	SLC40A1/VDAC2/NCOA4/SLC7A11/TP53/ACSL3/SAT2/GCLM/HMOX1/PCBP2/CP/ATG7/MAP1LC3B/MAP1LC3A/SLC11A2/FTMT/SLC39A14/ATG5/TF/ACSL5/PCBP1/FTL/MAP1LC3B2	23
KEGG	hsa03030	DNA replication	20/5183	36/8144	0.881	1	0.7532	RNASEH2B/MCM2/RPA3/MCM3/PRIM2/RPA1/RFC5/POLA2/MCM7/RNASEH2C/RPA2/POLE/RFC3/POLD4/MCM6/POLD3/PRIM1/LIG1/PCNA/FEN1	20
KEGG	hsa04932	Non-alcoholic fatty liver disease	92/5183	155/8144	0.8853	1	0.7532	FASLG/PIK3CD/IL1B/PRKAA1/TNF/XBP1/CEBPA/NR1H3/NDUFS8/NDUFS2/PRKAG1/IL6R/ADIPOR2/PPARG/TNFRSF1A/RXRA/CDC42/SREBF1/NFKB1/INS/NDUFB6/COX6B2/NDUFA7/PRKAA2/NDUFB10/NDUFA5/MAPK10/RAC1/PRKAG3/AKT2/COX7B2/CASP8/MAPK12/PIK3R2/DDIT3/NDUFB8/UQCRFS1/MAP3K5/COX8C/MAPK9/NDUFV2/COX4I2/LEP/LEPR/PIK3R1/ADIPOR1/CASP3/IRS2/NDUFAB1/MAP3K11/CYCS/COX7A1/NDUFS6/NDUFV1/IRS1/NDUFC1/NDUFS5/NDUFS7/EIF2AK3/INSR/BCL2L11/COX6A1/COX6C/RELA/NDUFS1/NDUFA4L2/COX6B1/PIK3R3/UQCRQ/NDUFA11/PRKAG2/MAPK14/PIK3CB/SDHA/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/NDUFB5/MLXIPL/NDUFA6/FOS/ITCH/MLXIP/NDUFA8/NDUFB1/COX5A/NDUFB2/BID/ATF4/SDHC	92
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14/5183	26/8144	0.892	1	0.7532	PIGY/PIGX/PIGP/PIGV/PIGQ/PIGB/PIGG/PIGC/PIGS/PIGL/GPAA1/PIGK/GPLD1/PGAP1	14
KEGG	hsa01230	Biosynthesis of amino acids	43/5183	75/8144	0.8955	1	0.7532	PSAT1/PGK2/ARG1/TKT/PYCR2/TKTL2/ALDOB/PC/ARG2/GOT1L1/IDH3A/GLUL/CPS1/ALDOC/ACO1/GPT/CS/GPT2/ENO1/SHMT1/MAT1A/PHGDH/TPI1/GAPDH/MAT2A/ACO2/SDSL/ENO3/BCAT1/PRPS1L1/SDS/GOT1/CBS/PGAM4/ASNS/PSPH/ASS1/OTC/SHMT2/RPE/PGAM2/IDH2/NAGS	43
KEGG	hsa00051	Fructose and mannose metabolism	18/5183	33/8144	0.8966	1	0.7532	FBP2/PFKFB2/FBP1/ALDOB/AKR1B10/ALDOC/MPI/TSTA3/HKDC1/GMPPB/TPI1/HK3/PFKFB3/HK1/GMPPA/GMDS/FPGT/PMM2	18
KEGG	hsa04150	mTOR signaling pathway	92/5183	156/8144	0.9037	1	0.7532	RPS6KB2/PIK3CD/PRKAA1/TNF/RPS6KA1/PRR5/CAB39L/MAPK3/LRP6/WNT8A/FZD6/FZD10/TNFRSF1A/RRAGD/SGK1/WNT2/GRB2/WNT11/PTEN/INS/FZD8/PRKAA2/WNT10A/LPIN1/FZD2/AKT2/ATP6V1B1/PIK3R2/ATP6V1B2/STRADA/RPS6/NRAS/SESN2/ATP6V1C1/MAPK1/ATP6V1G3/TSC2/WNT3A/EIF4E1B/WNT7A/MAP2K2/PIK3R1/HRAS/RAF1/EIF4EBP1/WNT9B/WDR24/ATP6V1H/TSC1/KRAS/WNT5A/DVL1/IRS1/RHEB/WNT2B/MAP2K1/MIOS/RPS6KB1/INSR/IGF1R/STK11/FLCN/ATP6V1E1/FZD4/CLIP1/ATP6V1D/PIK3R3/ATP6V1F/WNT9A/CAB39/RPS6KA2/SEC13/DEPDC5/WNT7B/TELO2/SOS2/WDR59/WNT1/PIK3CB/PRR5L/WNT4/WNT16/DVL3/LPIN3/MTOR/EIF4E2/BRAF/PRKCB/FNIP2/SOS1/FZD5/LRP5	92
KEGG	hsa00514	Other types of O-glycan biosynthesis	26/5183	47/8144	0.9088	1	0.7532	GXYLT1/ST6GAL1/GALNT5/GALNT3/GALNT9/GALNT12/B4GALT1/GALNT13/ST3GAL3/GALNT8/GALNT10/B4GALT3/MFNG/GALNT1/ST6GAL2/GALNT6/GALNTL5/POFUT2/C1GALT1/POFUT1/GALNT11/GXYLT2/RFNG/GALNT4/GALNTL6/GALNT7	26
KEGG	hsa00030	Pentose phosphate pathway	16/5183	30/8144	0.9123	1	0.7532	FBP2/PGD/FBP1/TKT/TKTL2/ALDOB/PGM1/H6PD/ALDOC/GPI/RBKS/PRPS1L1/DERA/GLYCTK/PGM2/RPE	16
KEGG	hsa00640	Propanoate metabolism	17/5183	32/8144	0.9209	1	0.7532	BCKDHB/ACSS1/BCKDHA/ACSS2/LDHAL6B/ACOX3/SUCLG2/SUCLG1/ACSS3/DLD/DBT/ALDH6A1/LDHA/LDHB/ACACA/PCCB/LDHC	17
KEGG	hsa04110	Cell cycle	73/5183	126/8144	0.9233	1	0.7532	YWHAG/E2F1/PRKDC/RBL1/CDC25B/SMAD2/CDKN2B/GADD45G/CCND2/CDC14B/CDKN1A/MCM2/TP53/YWHAZ/RAD21/PTTG2/CDKN2A/CDKN1C/MCM3/CCNA1/CDKN2D/ANAPC10/CDK6/EP300/MAD2L1/FZR1/PKMYT1/CDC26/HDAC1/ZBTB17/MDM2/TGFB2/E2F3/SFN/BUB3/ATM/ABL1/MCM7/CCNB3/TFDP1/CDC16/CCNH/CDK2/CDC20/CCND3/DBF4/CDKN2C/MCM6/CDC6/GADD45A/MAD2L2/CHEK2/SMAD4/WEE2/CREBBP/PLK1/E2F2/HDAC2/CDC7/E2F4/CCNE1/BUB1B/TFDP2/SMAD3/RBL2/PCNA/MAD1L1/TTK/CDKN1B/ANAPC11/RB1/ANAPC2/CDK7	73
KEGG	hsa04114	Oocyte meiosis	76/5183	131/8144	0.9242	1	0.7532	YWHAG/RPS6KA1/CALML3/CALML6/ITPR1/CALML4/MAPK3/SPDYE4/CALML5/REC8/PPP2R5C/CAMK2A/CPEB2/ADCY4/STAG3/PRKACA/YWHAZ/INS/CAMK2B/ADCY5/PTTG2/CAMK2G/PLCZ1/PPP2R5A/BTRC/AURKA/PPP2R5E/MAPK12/ANAPC10/SPDYE5/MAD2L1/SPDYC/ITPR2/FBXO5/ADCY3/MAPK1/FBXW11/PKMYT1/CDC26/SPDYE1/ADCY6/PPP2R5B/CALM1/ADCY2/ADCY8/CALM2/PPP2CB/PPP2R5D/PPP3R1/MAP2K1/PPP3CA/CDC16/ADCY7/CDK2/CDC20/IGF1R/CPEB1/PGR/PPP3CC/PPP3CB/PRKACB/PPP2R1A/RPS6KA2/MAD2L2/FBXO43/SPDYE3/MAPK14/PLK1/CCNE1/PPP3R2/ADCY1/CALM3/PPP2CA/MAD1L1/ANAPC11/ANAPC2	76
KEGG	hsa00100	Steroid biosynthesis	10/5183	20/8144	0.9313	1	0.7532	CEL/SOAT2/LIPA/DHCR24/SQLE/CYP24A1/CYP51A1/CYP27B1/SOAT1/HSD17B7	10
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	19/5183	36/8144	0.9353	1	0.7532	NMNAT2/SIRT2/SIRT7/NNT/ENPP3/AOX1/NT5C1A/CD38/QPRT/NADK/SIRT5/NT5C2/SIRT4/NADSYN1/NT5M/ENPP1/NMNAT3/NT5E/SIRT3	19
KEGG	hsa00410	beta-Alanine metabolism	16/5183	31/8144	0.9411	1	0.7532	ALDH3B1/ALDH3B2/AOC3/AOC2/SMOX/ALDH2/UPB1/ALDH3A2/ACOX3/ALDH7A1/GAD2/DPYD/ALDH6A1/GADL1/GAD1/ALDH9A1	16
KEGG	hsa00513	Various types of N-glycan biosynthesis	20/5183	39/8144	0.9602	1	0.7532	RPN1/MGAT4A/CHST9/B4GALT1/MGAT1/FUT8/STT3B/B4GALNT3/ST3GAL3/DDOST/B4GALT3/TUSC3/MGAT4C/MAN2A2/ALG2/HEXA/HEXB/MAN2A1/ALG14/ALG9	20
KEGG	hsa03440	Homologous recombination	21/5183	41/8144	0.9638	1	0.7532	RPA3/BRIP1/BARD1/RAD51C/RPA1/XRCC3/BRCA2/ATM/RBBP8/RAD50/EME1/RPA2/POLD4/PALB2/POLD3/BLM/RAD54L/RAD54B/TOP3A/SYCP3/XRCC2	21
KEGG	hsa00071	Fatty acid degradation	22/5183	43/8144	0.9671	1	0.7532	ACSBG1/ALDH2/ACSL3/ADH6/ACAT1/ADH7/ACADL/ACSBG2/ADH1C/ALDH3A2/ACOX3/ADH1B/ALDH7A1/CPT2/ACAA2/GCDH/CPT1C/ADH5/HADH/ACSL5/ALDH9A1/ADH4	22
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	13/5183	27/8144	0.9677	1	0.7532	ELOVL3/TECR/ELOVL6/SCD5/FADS2/BAAT/ACOX3/ACOT7/ELOVL4/SCD/ELOVL7/HSD17B4/ELOVL5	13
KEGG	hsa01212	Fatty acid metabolism	30/5183	57/8144	0.9678	1	0.7532	ELOVL3/TECR/PPT1/ELOVL6/ACSBG1/SCD5/FADS2/ACSL3/HSD17B8/ACAT1/ACSF3/ACADL/ACSBG2/MCAT/ACOX3/OXSM/FASN/CPT2/ACAA2/ELOVL4/MECR/CPT1C/ACACA/CBR4/HADH/ACSL5/SCD/ELOVL7/HSD17B4/ELOVL5	30
KEGG	hsa00900	Terpenoid backbone biosynthesis	10/5183	22/8144	0.9751	1	0.7532	DHDDS/PMVK/FDPS/HMGCS2/ACAT1/PCYOX1/PDSS1/GGPS1/IDI2/MVK	10
KEGG	hsa04623	Cytosolic DNA-sensing pathway	33/5183	63/8144	0.9756	1	0.7532	IL1B/IL18/IKBKE/PYCARD/CCL5/POLR2L/IFNA7/NFKBIA/POLR2E/RIPK1/NFKB1/CASP1/CCL4/AIM2/IFNA8/CXCL10/NFKBIB/POLR2K/MAVS/POLR2F/IL33/TREX1/RELA/POLR3D/IFNA4/IFNA14/POLR3H/POLR3GL/TBK1/POLR3A/IRF3/POLR1D/POLR2H	33
KEGG	hsa05010	Alzheimer disease	226/5183	384/8144	0.9793	1	0.7532	PIK3CD/IL1B/TNF/CSNK1E/XBP1/VDAC2/NDUFS8/NDUFS2/CALML3/BACE1/CALML6/ITPR1/CALML4/MAPK3/LRP6/APH1A/FRAT1/WNT8A/RTN3/APH1B/CALML5/KLC2/FZD6/FZD10/TNFRSF1A/FRAT2/SLC25A31/WNT2/SNCA/WNT11/NFKB1/RTN4/LRP1/INS/NDUFB6/CHRM3/SLC39A13/COX6B2/NDUFA7/TUBB/FZD8/CSNK1A1L/WNT10A/ATP2A1/FADD/NDUFB10/NDUFA5/DKK1/FZD2/BACE2/CHRM1/AXIN2/MAPK10/NOX4/MME/CDK5R1/AKT2/PSMD13/CHRNA7/PSMB7/COX7B2/CASP8/PIK3R2/RB1CC1/TUBA3C/DDIT3/NDUFB8/ITPR2/NRAS/UQCRFS1/PSMC2/MAP3K5/SLC39A11/ADAM10/MAPK1/COX8C/PSMD1/WNT3A/CACNA1S/MAPK9/TUBA3E/NDUFV2/WNT7A/COX4I2/MAP2K2/KIF5B/PIK3R1/TUBA4A/HRAS/RAF1/GRIN2B/PSMC6/DKK2/TUBA1A/WNT9B/PSMB4/CASP3/CALM1/IRS2/NDUFAB1/KRAS/CASP9/TUBB3/GRIN2C/APP/SLC39A1/CYCS/TUBA3D/GAPDH/PLCB1/COX7A1/WNT5A/DKK4/NDUFS6/DVL1/PTGS2/NDUFV1/PSENEN/PSMC4/CALM2/CSNK2A1/ATG2B/IRS1/PSMD2/PSMA4/NDUFC1/GNAQ/WNT2B/WIPI1/PPP3R1/MAP2K1/AXIN1/PPP3CA/CSNK1A1/PSMC5/CSNK2B/NDUFS5/NDUFS7/SLC11A2/PLCB4/EIF2AK2/EIF2AK3/TUBB8/GRIN2A/INSR/TUBA8/CSNK2A2/PSMD14/SLC39A4/KIF5C/COX6A1/TUBB2A/COX6C/RELA/TUBA1B/PLCB2/KLC4/NDUFS1/GRM5/NDUFA4L2/AMBRA1/FZD4/CTNNB1/PPP3CC/ADAM17/NOS2/SLC39A12/SLC39A14/COX6B1/PPP3CB/PIK3R3/PSMB5/PSMB2/UQCRQ/PLCB3/WNT9A/NDUFA11/PPID/CAPN2/PSMD8/APC/WNT7B/PSMB6/NAE1/PSMD7/WNT1/PIK3CB/KLC1/SDHA/PSMD12/AGER/WNT4/WNT16/SDHB/NDUFA10/CYC1/COX6A2/IDE/UQCRHL/SLC39A9/PSMD6/DVL3/NDUFB5/NDUFA6/PPP3R2/CDK5/MTOR/CALM3/NDUFA8/BRAF/NDUFB1/COX5A/ATF6/SLC39A10/NOS1/NDUFB2/BID/CHRM5/ATG2A/ATF4/FZD5/CAPN1/TUBA1C/LRP5/SDHC/PSEN1	226
KEGG	hsa04120	Ubiquitin mediated proteolysis	79/5183	142/8144	0.9807	1	0.7532	CBL/FBXW7/UBE2K/AIRE/UBA7/UBE2Z/STUB1/MGRN1/CUL3/CUL2/UBE4A/RCHY1/UBE3A/UBE2D3/UBR5/UBE2H/BIRC2/BTRC/ANAPC10/UBB/UBE2L6/SMURF1/FBXO4/UBE2Q2/FZR1/DET1/UBA3/HERC2/TRAF6/WWP2/FBXO2/FBXW11/FBXW8/CDC26/CDC34/CBLC/UBE3C/MDM2/KLHL9/UBC/KLHL13/UBE2R2/MAP3K1/PRPF19/BIRC7/BIRC3/UBE2Q1/CDC16/WWP1/NEDD4L/CBLB/UBE2W/CDC20/SIAH1/UBE2E1/UBE2U/SOCS1/TRIM32/UBA6/UBA2/UBE2QL1/ERCC8/SYVN1/TRIP12/PPIL2/UBE2I/UBE2C/ITCH/NHLRC1/RHOBTB1/VHL/PIAS3/ANAPC11/PIAS2/RNF7/ANAPC2/MID1/RHOBTB2/UBOX5	79
KEGG	hsa05131	Shigellosis	142/5183	247/8144	0.9818	1	0.7532	TLR4/RPS6KB2/PIK3CD/IL1B/TNF/RIPK2/IL18/FNBP1/PYCARD/MYL7/CYTH1/NLRC4/ITGA5/CCL5/CAST/ELMO1/ACTB/NLRP3/TLR5/TLN2/ITPR1/MAPK3/BCL2L1/PRKCD/NOD1/NAIP/DIAPH1/TNFRSF1A/RRAGD/MYL9/SQSTM1/VCL/NFKBIA/IL1R1/CDC42/TLN1/RIPK1/TP53/PTK2/NFKB1/CASP1/PLCE1/RPS6KA5/FOXO3/PLCZ1/UBE2D3/GLMN/CD44/BCL10/BTRC/MAPK10/RAC1/AKT2/MYL10/MAPK12/PIK3R2/CASP4/UBB/HKDC1/CSF2/ITPR2/CYTH4/PFN2/PLCG1/TRAF6/MAPK1/TRAF5/FBXW11/SHARPIN/MYL5/ARHGEF2/U2AF1L4/MAPK9/TIFA/PIK3R1/ARF1/ARPC4/TNIP1/MAP1LC3B/EGFR/MYL2/HK3/BCAR1/MALT1/CYCS/MDM2/ARF6/PLCB1/NFKBIB/UBC/RNF31/MYLPF/ATM/RBCK1/MAP1LC3A/WIPI1/PLCD3/CALCOCO2/PFN1/BCL2/PFN4/ITGB1/FNBP1L/FOXO1/RPS6KB1/PLCB4/CD14/RELA/HK1/PLCB2/CYTH3/ATG5/PIK3R3/C3/PLCD4/PLCB3/PPID/CAPN2/PLCG2/MAPK14/MYL12A/PLCD1/ATG16L1/ACTR3C/CYTH2/TBK1/CAPNS1/PIK3CB/PXN/ACTR2/ROCK1/TECPR1/ELMO2/ARPC5L/ROCK2/MTOR/ACTR3B/IRF3/PRKCE/CAPN1/MAP1LC3B2/ACTG1	142
KEGG	hsa03022	Basal transcription factors	22/5183	45/8144	0.9854	1	0.7532	ERCC3/GTF2IRD1/MNAT1/TAF8/GTF2E2/TAF12/GTF2H5/GTF2I/TAF5L/TAF13/CCNH/GTF2F2/GTF2E1/GTF2F1/GTF2A1L/GTF2A2/TAF5/TBPL1/TAF2/TAF6L/TAF3/CDK7	22
KEGG	hsa00515	Mannose type O-glycan biosynthesis	10/5183	23/8144	0.9856	1	0.7532	FUT4/FKRP/FUT9/B4GALT1/ST3GAL3/MGAT5B/B4GALT3/CHST10/B3GALNT2/POMGNT1	10
KEGG	hsa00062	Fatty acid elongation	12/5183	27/8144	0.9872	1	0.7532	ELOVL3/TECR/PPT1/ELOVL6/THEM5/ACOT7/ACAA2/ELOVL4/MECR/HADH/ELOVL7/ELOVL5	12
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	280/5183	476/8144	0.9889	1	0.7532	FASLG/IL1B/TNF/CSNK1E/XBP1/DNAH3/VDAC2/NDUFS8/NDUFS2/CALML3/DCTN2/GPX3/STX1A/CALML6/ITPR1/CALML4/MAPK3/BCL2L1/LRP6/NEFH/FRAT1/UBA7/WNT8A/SPTBN2/GRIA1/DNAH8/CALML5/KLC2/FZD6/FZD10/TNFRSF1A/SQSTM1/FRAT2/GRIA4/DNAH17/GPX6/SLC25A31/CAMK2A/WNT2/DNAH10/SNCA/WNT11/NFKB1/ATXN2/NDUFB6/CAMK2B/CHRM3/NEFM/GRIA2/COX6B2/NEFL/NDUFA7/CAMK2G/TUBB/FZD8/ZFYVE1/CSNK1A1L/WNT10A/ATP2A1/ATXN1/FADD/MAP3K10/RYR1/NDUFB10/NDUFA5/DKK1/FZD2/CHRM1/AXIN2/MAPK10/RAB1A/RAC1/NOX4/CDK5R1/PSMD13/CHRNA7/PSMB7/COX7B2/CASP8/MAPK12/SPG11/RB1CC1/TUBA3C/UBB/PRPH/UBE2L6/DDIT3/NDUFB8/ITPR2/NRAS/UQCRFS1/PSMC2/TNFRSF1B/MAP3K5/DNAH2/PLCG1/MAPK1/COX8C/PSMD1/LRRK2/WNT3A/CACNA1S/MAPK9/TUBA3E/NDUFV2/WNT7A/COX4I2/UCHL1/MAP2K2/GRM1/KIF5B/TUBA4A/SLC6A3/HRAS/RAF1/GRIN2B/MAP1LC3B/PSMC6/DKK2/ACTR1A/TUBA1A/VAPB/WNT9B/PDYN/PSMB4/CASP3/CALM1/MAP2K6/NDUFAB1/KRAS/CASP9/TUBB3/DNAH5/GRIN2C/APP/CYCS/BDNF/TUBA3D/PLCB1/COX7A1/UBC/WNT5A/DKK4/NDUFS6/DVL1/PTGS2/NDUFV1/DCTN6/PSMC4/CALM2/OPTN/DNAL1/CSNK2A1/DCTN3/DERL1/ATG2B/PSMD2/GPX2/PSMA4/NDUFC1/GNAQ/MAP1LC3A/WNT2B/WIPI1/PPP3R1/MAP2K1/AXIN1/VCP/PPP3CA/CSNK1A1/PSMC5/CSNK2B/NDUFS5/BCL2/CACNA1B/NDUFS7/RYR2/PLCB4/EIF2AK3/TUBB8/GRIN2A/DNAI2/TUBA8/CSNK2A2/PSMD14/KIF5C/COX6A1/TUBB2A/DCTN4/COX6C/RELA/DNAH12/TUBA1B/PLCB2/KLC4/NDUFS1/GRM5/NDUFA4L2/AMBRA1/SOD1/IFT57/FZD4/PINK1/CTNNB1/PPP3CC/NOS2/COX6B1/DNAI1/PPP3CB/PSMB5/PSMB2/UQCRQ/PLCB3/WNT9A/GPX5/FUS/NDUFA11/GPX1/PPID/CAPN2/PSMD8/APC/DLG4/MAPK14/GPX8/WNT7B/PSMB6/TBK1/PSMD7/WNT1/MAP2K3/KLC1/HTT/SDHA/PSMD12/HIP1/AGER/WNT4/WNT16/SDHB/NDUFA10/CYC1/COX6A2/HSPA5/UQCRHL/DNAH11/PSMD6/DVL3/NDUFB5/NDUFA6/PPP3R2/CDK5/MTOR/CALM3/NDUFA8/BRAF/NDUFB1/COX5A/ATF6/ALS2/PRKCB/ATXN1L/NOS1/NDUFB2/BID/ACTR10/CHRM5/ATG2A/DNAL4/ATF4/FZD5/CCS/CAPN1/ATXN2L/MAP1LC3B2/DCTN1/TUBA1C/LRP5/SDHC/PSEN1	280
KEGG	hsa05017	Spinocerebellar ataxia	78/5183	143/8144	0.9904	1	0.7532	PIK3CD/RORA/XBP1/VDAC2/ITPR1/SPTBN2/GRIA1/MYOD1/SLC25A31/ATXN2/GRIN3A/KCND3/GRIA2/CACNA1A/SP1/ATP2A1/ATXN1/RYR1/MAPK10/AKT2/PSMD13/PSMB7/PIK3R2/RB1CC1/ITPR2/PUM1/NOP56/PSMC2/MAP3K5/PSMD1/MAPK9/KCNC3/GRM1/PIK3R1/DAB1/GRIN2B/PSMC6/VLDLR/PDYN/PSMB4/SLC1A6/GRIN2C/CYCS/PLCB1/PSMC4/ATG2B/PSMD2/PSMA4/GNAQ/FGF14/WIPI1/PSMC5/PLCB4/GRIN3B/GRIN2A/PSMD14/PLCB2/AMBRA1/AFG3L2/PIK3R3/PSMB5/PSMB2/PLCB3/PSMD8/KAT5/PSMB6/PSMD7/PIK3CB/PSMD12/TBPL1/PSMD6/MTOR/PRKCB/ATXN1L/PUM2/CIC/ATG2A/ATXN2L	78
KEGG	hsa00510	N-Glycan biosynthesis	24/5183	50/8144	0.992	1	0.7532	RPN1/MGAT3/MGAT4A/ST6GAL1/MGAT5/B4GALT1/MGAT1/FUT8/STT3B/MGAT5B/DDOST/B4GALT3/TUSC3/MGAT4C/ST6GAL2/MOGS/MAN2A2/ALG2/ALG6/GANAB/MAN2A1/ALG14/DPAGT1/ALG9	24
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	125/5183	223/8144	0.9925	1	0.7532	PIK3CD/VDAC2/GSTT2B/NDUFS8/NDUFS2/PTPRJ/CYP1A2/ARNT/ABL2/MAPK3/GSTA5/PRKCD/LPO/GSTA4/GSTT2/PRKD3/HGF/NFKBIA/SLC25A31/GSTM2/GRB2/PTK2/NFKB1/NCF2/PTEN/NDUFB6/AKR1C4/HIF1A/COX6B2/FOXO3/NDUFA7/NDUFB10/AKR1C1/NDUFA5/MAPK10/EPHX1/EPHX3/RAC1/NOX4/MET/AKT2/COX7B2/NFE2L2/MAPK12/PIK3R2/SLC26A9/HMOX1/PLD1/NDUFB8/MAP3K14/NRAS/UQCRFS1/MAP3K5/MAPK1/CYP2F1/COX8C/GSTA2/MAPK9/NDUFV2/COX4I2/GSTA1/MAP2K2/PIK3R1/HRAS/RAF1/EGFR/MAP2K4/AS3MT/NDUFAB1/KRAS/SLC26A6/SLC26A1/COX7A1/NDUFS6/NDUFV1/MGST1/ABL1/NDUFC1/PLD2/NQO1/CYBA/MAP2K1/EGF/NDUFS5/NDUFS7/NCF1/COX6A1/COX6C/RELA/MGST2/NDUFS1/NDUFA4L2/SOD1/COX6B1/PIK3R3/UQCRQ/GSTM4/NDUFA11/MAPK14/GSTT1/SOS2/PRKD1/GSTM3/PIK3CB/SDHA/CYP1A1/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/NDUFB5/NDUFA6/FOS/NDUFA8/BRAF/NDUFB1/COX5A/CYP1B1/AHR/NDUFB2/AKR1C2/AKR1C3/SOS1/SDHC	125
KEGG	hsa05020	Prion disease	155/5183	273/8144	0.9926	1	0.7532	PIK3CD/IL1B/TNF/VDAC2/NDUFS8/NDUFS2/CCL5/CREB3L2/ITPR1/MAPK3/PRKCD/C1QB/CAV3/FYN/CREB3L4/KLC2/C1QA/HSPA8/SLC25A31/NCF4/NCF2/PRKACA/GRIN3A/NDUFB6/C9/COX6B2/NDUFA7/TUBB/CREB5/RYR1/C8B/NCAM2/NDUFB10/NDUFA5/C7/MAPK10/C6/RAC1/PSMD13/PSMB7/COX7B2/MAPK12/PIK3R2/TUBA3C/DDIT3/C8A/NDUFB8/ITPR2/UQCRFS1/PSMC2/MAPK1/COX8C/PSMD1/C5/CACNA1S/MAPK9/TUBA3E/NDUFV2/C1QC/COX4I2/KIF5B/PIK3R1/TUBA4A/ATF2/GRIN2B/PSMC6/TUBA1A/PSMB4/CASP3/CAV1/CREB3L3/NDUFAB1/CASP9/TUBB3/GRIN2C/CYCS/TUBA3D/COX7A1/NDUFS6/NDUFV1/PSMC4/CSNK2A1/CREB3/PSMD2/PSMA4/NDUFC1/CYBA/PPP3R1/HSPA1A/PPP3CA/HSPA2/PSMC5/CSNK2B/NDUFS5/CACNA1B/NDUFS7/RYR2/HSPA1L/EIF2AK3/GRIN3B/TUBB8/GRIN2A/TUBA8/CSNK2A2/PSMD14/NCF1/RAC2/KIF5C/C8G/COX6A1/TUBB2A/COX6C/TUBA1B/KLC4/NDUFS1/NDUFA4L2/SOD1/PPP3CC/COX6B1/PPP3CB/PRKACB/PIK3R3/EGR1/PSMB5/PSMB2/UQCRQ/NDUFA11/PSMD8/MAPK14/NCAM1/PSMB6/PSMD7/PIK3CB/KLC1/SDHA/PSMD12/SDHB/NDUFA10/CYC1/COX6A2/HSPA5/UQCRHL/PSMD6/NDUFB5/NDUFA6/PPP3R2/NDUFA8/NDUFB1/COX5A/NDUFB2/CAV2/ATF4/CREB1/TUBA1C/SDHC	155
KEGG	hsa04622	RIG-I-like receptor signaling pathway	35/5183	70/8144	0.9932	1	0.7532	TNF/IKBKE/CASP10/IFNK/IFNA7/NFKBIA/AZI2/RIPK1/NFKB1/FADD/NLRX1/IFNA8/IL12B/CYLD/CXCL10/MAPK10/CASP8/MAPK12/TRAF6/MAPK9/ISG15/NFKBIB/MAP3K1/MAVS/TRIM25/RELA/PIN1/ATG5/IFNA4/IFNA14/MAPK14/TBK1/TRAF3/IRF3/RNF125	35
KEGG	hsa04140	Autophagy - animal	76/5183	141/8144	0.9935	1	0.7532	RPS6KB2/PIK3CD/PRKAA1/ITPR1/MAPK3/BCL2L1/PRKCD/RRAGD/SQSTM1/PRKACA/PTEN/INS/TP53INP2/HIF1A/MTMR3/MTMR14/ZFYVE1/PRKAA2/LAMP1/CAMKK2/MAPK10/RAB1A/AKT2/PIK3R2/RB1CC1/NRAS/ATG4B/TRAF6/MAPK1/ATG7/ATG4D/TSC2/MAPK9/RRAS/DAPK3/MAP2K2/PIK3R1/HRAS/RAF1/MAP1LC3B/DAPK2/TSC1/IRS2/KRAS/CTSB/CFLAR/ATG2B/VAMP8/IRS1/PPP2CB/RHEB/MAP1LC3A/WIPI1/MAP2K1/BCL2/RPS6KB1/EIF2AK3/CTSD/IGF1R/STK11/ATG10/AMBRA1/HMGB1/ATG5/PRKACB/PIK3R3/EIF2AK4/ATG16L2/ATG16L1/TBK1/PIK3CB/ATG9B/MTOR/PPP2CA/ATG2A/MAP1LC3B2	76
KEGG	hsa03015	mRNA surveillance pathway	50/5183	97/8144	0.9947	1	0.7532	WDR82/SMG1/NXF1/MSI2/CPSF3/PPP2R5C/PPP2R2C/PABPN1L/ETF1/RNMT/ACIN1/SYMPK/EIF4A3/PPP2R5A/PPP2R5E/RNGTT/SMG5/CPSF1/PPP2R2A/PPP2R2D/PPP2R5B/SMG7/UPF3A/PAPOLG/UPF1/PPP2CB/PPP2R5D/FIP1L1/DDX19A/CPSF2/PABPC4L/NCBP1/DDX19B/SSU72/HBS1L/PABPC5/PPP2R1A/PABPC4/FUS/CSTF3/PPP2R3A/PABPC1L/CLP1/PAPOLB/PPP2R3C/PPP2CA/CPSF4/NUDT21/GLE1/CPSF4L	50
KEGG	hsa00450	Selenocompound metabolism	6/5183	17/8144	0.9957	1	0.7532	INMT/TXNRD2/PAPSS1/PSTK/TXNRD1/PAPSS2	6
KEGG	hsa05016	Huntington disease	173/5183	306/8144	0.9962	1	0.7532	DNAH3/VDAC2/RCOR1/NDUFS8/NDUFS2/DCTN2/POLR2L/CREB3L2/GPX3/STX1A/ITPR1/SLC1A3/GRIA1/CREB3L4/DNAH8/PPARG/KLC2/GRIA4/DNAH17/GPX6/SLC25A31/POLR2E/UCP1/DNAH10/TP53/NDUFB6/GRIA2/COX6B2/NDUFA7/TUBB/SP1/CREB5/MAP3K10/NDUFB10/NDUFA5/MAPK10/PSMD13/PSMB7/COX7B2/CASP8/RB1CC1/TUBA3C/CLTA/EP300/POLR2B/NDUFB8/UQCRFS1/PSMC2/MAP3K5/DNAH2/COX8C/PSMD1/MAPK9/TUBA3E/HDAC1/NDUFV2/COX4I2/KIF5B/TUBA4A/GRIN2B/PSMC6/ACTR1A/TUBA1A/PSMB4/CASP3/CREB3L3/NDUFAB1/CASP9/TUBB3/DNAH5/CYCS/CLTC/BDNF/TUBA3D/PLCB1/COX7A1/NDUFS6/NDUFV1/AP2M1/DCTN6/POLR2K/PSMC4/DNAL1/REST/DCTN3/CREB3/ATG2B/PSMD2/GPX2/PSMA4/NDUFC1/GNAQ/WIPI1/POLR2A/KCNJ10/PSMC5/POLR2F/NDUFS5/POLR2G/CACNA1B/NDUFS7/PLCB4/TUBB8/DNAI2/TUBA8/PSMD14/KIF5C/COX6A1/NRF1/TUBB2A/DCTN4/COX6C/AP2A2/DNAH12/TUBA1B/PLCB2/KLC4/NDUFS1/GRM5/NDUFA4L2/AMBRA1/SOD1/IFT57/COX6B1/DNAI1/PSMB5/PSMB2/UQCRQ/PLCB3/GPX5/NDUFA11/GPX1/PSMD8/DLG4/GPX8/SLC1A2/CREBBP/PSMB6/PSMD7/KLC1/HTT/SIN3A/SDHA/PSMD12/POLR2D/TBPL1/HDAC2/HIP1/BBC3/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/DNAH11/PSMD6/NDUFB5/NDUFA6/MTOR/AP2S1/NDUFA8/NDUFB1/COX5A/NDUFB2/POLR2H/ACTR10/ATG2A/DNAL4/CREB1/DCTN1/TUBA1C/SDHC/POLR2J2	173
KEGG	hsa04136	Autophagy - other	13/5183	32/8144	0.9977	1	0.7532	ATG4B/ATG7/ATG4D/ATG2B/PPP2CB/WIPI1/ATG10/ATG5/ATG16L1/ATG9B/MTOR/PPP2CA/ATG2A	13
KEGG	hsa00310	Lysine degradation	29/5183	63/8144	0.9986	1	0.7532	SMYD1/PRDM7/PRDM16/ALDH2/BBOX1/ACAT1/EZH2/DHTKD1/AADAT/MECOM/ALDH3A2/SETD1A/AASS/EHMT1/ASH1L/SMYD3/ALDH7A1/DLD/PLOD2/EHMT2/PLOD1/GCDH/SUV39H2/HADH/ALDH9A1/EZH1/SETD2/SETD1B/PRDM2	29
KEGG	hsa03460	Fanconi anemia pathway	24/5183	54/8144	0.9987	1	0.7532	ERCC1/FANCE/RPA3/BRIP1/RAD51C/HES1/POLN/RPA1/EME2/BRCA2/FANCC/PMS2/EME1/RPA2/PALB2/WDR48/BLM/FANCI/TELO2/FANCM/TOP3A/ATRIP/POLK/USP1	24
KEGG	hsa03420	Nucleotide excision repair	20/5183	47/8144	0.999	1	0.7532	ERCC3/ERCC1/MNAT1/RPA3/GTF2H5/RPA1/ERCC6/RFC5/CCNH/RPA2/POLE/RFC3/POLD4/ERCC8/POLD3/XPA/LIG1/PCNA/XPC/CDK7	20
KEGG	hsa04146	Peroxisome	39/5183	82/8144	0.999	1	0.7532	CRAT/PEX5/PRDX5/PMVK/FAR2/HAO1/ABCD4/HMGCLL1/HAO2/ACSL3/DAO/BAAT/PEX10/ACOX3/PEX26/ACOX2/MPV17L/AMACR/PXMP2/SLC27A2/SLC25A17/HMGCL/PEX5L/SOD1/NOS2/PAOX/ABCD2/GSTK1/PEX11A/ACSL5/PEX19/MPV17/PEX13/HSD17B4/MPV17L2/MVK/IDH2/NUDT7/PEX14	39
KEGG	hsa03018	RNA degradation	37/5183	79/8144	0.9992	1	0.7532	DCP2/DCP1A/DDX6/LSM4/CNOT10/BTG4/ENO1/EXOSC7/EXOSC6/SKIV2L/CNOT1/DHX36/CNOT6/PARN/ENO3/DCPS/PABPC4L/PABPC5/PABPC4/C1D/HSPA9/BTG2/PABPC1L/EXOSC10/NUDT16/LSM2/LSM6/PAN3/EXOSC2/DIS3/CNOT2/CNOT4/EDC4/PAN2/TTC37/BTG3/LSM3	37
KEGG	hsa04217	Necroptosis	81/5183	159/8144	0.9996	1	0.7532	FASLG/TLR4/IL1B/TNF/VDAC2/IFNG/IFNGR2/PYCARD/NLRP3/JAK1/STAT5A/PLA2G4A/CHMP7/IFNA7/TNFRSF1A/SQSTM1/TNFSF10/STAT3/TICAM2/SLC25A31/CAMK2A/RIPK1/CASP1/CAMK2B/PYGL/GLUL/PLA2G4E/CAMK2G/PYGM/FADD/PLA2G4D/IFNA8/BIRC2/CYLD/CHMP1A/MAPK10/CASP8/TRAF5/PLA2G4C/SHARPIN/IRF9/MAPK9/TNFRSF10A/SPATA2/HSP90AA1/STAT6/CFLAR/TICAM1/RNF31/CHMP4A/BIRC3/TNFAIP3/RBCK1/USP21/BCL2/MLKL/IL33/STAT1/EIF2AK2/CHMP1B/GLUD1/PYGB/HMGB1/PARP1/SMPD1/PPID/CAPN2/IFNA4/IFNA14/PLA2G4F/HSP90AB1/STAT5B/CHMP4C/IFNAR2/FAF1/CHMP4B/BID/FTL/TNFRSF10B/CAPN1/VPS4A	81
KEGG	hsa04714	Thermogenesis	122/5183	232/8144	0.9998	1	0.7532	RPS6KB2/PNPLA2/PRKAA1/RPS6KA1/NDUFS8/NDUFS2/FGF21/ACTB/PRKAG1/CREB3L2/COX19/CREB3L4/PPARG/CNR1/SLC25A29/UCP1/ADCY4/GRB2/PRKACA/NDUFB6/PRDM16/COX6B2/ADCY5/NDUFA7/PRKAA2/ACSL3/CREB5/NDUFB10/NDUFA5/SLC25A20/SMARCB1/PRKAG3/COX7B2/MAPK12/RPS6/PRKG2/NDUFB8/NRAS/SMARCA4/GCG/UQCRFS1/MAP3K5/ADCY3/COX8C/FRS2/TSC2/NDUFV2/COX4I2/SMARCC1/HRAS/ATF2/ADCY6/TSC1/ADCY2/CREB3L3/NDUFAB1/KRAS/ADCY8/NDUFAF4/COX7A1/KDM1A/NDUFS6/NDUFV1/NPR1/FGFR1/CREB3/CPT2/RHEB/NDUFC1/NDUFS5/NDUFS7/ADCY7/NDUFAF3/RPS6KB1/COX6A1/COX6C/NDUFS1/NDUFA4L2/CPT1C/PRKG1/COX6B1/PRKACB/GNAS/UQCRQ/KDM3A/NDUFA11/RPS6KA2/PRKAG2/MAPK14/ACSL5/SOS2/SMARCD3/PLIN1/MAP2K3/ACTL6A/ARID1A/SDHA/NDUFAF2/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/ACTL6B/LIPE/NDUFB5/NDUFA6/MTOR/ADCY1/NDUFA8/NDUFB1/COX5A/ADRB3/COX10/NDUFB2/SMARCD2/SOS1/SMARCE1/KDM3B/CREB1/SDHC/ACTG1	122
KEGG	hsa04141	Protein processing in endoplasmic reticulum	86/5183	171/8144	0.9999	1	0.7532	RPN1/CALR/XBP1/PLAA/NSFL1C/FBXO6/RNF185/DNAJC5G/UBQLN3/CANX/UBXN2A/STUB1/CRYAA/HSPA8/LMAN1L/HSPA4L/UBE2D3/SEC31B/EDEM2/MAPK10/HSP90B1/NFE2L2/SEC61A1/SEC63/DDIT3/DNAJB1/DNAJA2/MAP3K5/STT3B/FBXO2/PRKCSH/P4HB/SAR1A/DDOST/LMAN2/MAPK9/DNAJB12/SEC61A2/TUSC3/LMAN1/AMFR/CKAP4/HSP90AA1/MBTPS1/SEC24C/DNAJC1/DERL1/NPLOC4/EDEM1/HSPA1A/VCP/TRAM1L1/HSPA2/BCL2/HSPA1L/EIF2AK2/EIF2AK3/TXNDC5/MOGS/NGLY1/SEL1L/SEC61B/SEC23B/EIF2AK4/UBQLN4/CAPN2/SEC13/SYVN1/TRAM1/UGGT2/HSP90AB1/HSPA5/SSR1/UBXN8/DNAJC5B/DNAJB2/GANAB/PDIA6/DNAJC10/SEC24A/ATF6/SEL1L2/BAG1/ATF4/CAPN1/UBQLN1	86
KEGG	hsa05415	Diabetic cardiomyopathy	104/5183	203/8144	0.9999	1	0.7532	PIK3CD/VDAC2/PLN/NDUFS8/NDUFS2/PRKCD/SMAD2/MMP9/ACE/SLC25A31/CAMK2A/TGFBR2/NCF4/CD36/NFKB1/NCF2/PTEN/INS/NDUFB6/CAMK2B/SLC2A1/COX6B2/COL1A1/NDUFA7/CAMK2G/SP1/GYS2/ATP2A1/NDUFB10/NDUFA5/MAPK10/RAC1/AKT2/COX7B2/MAPK12/TBC1D4/PIK3R2/NDUFB8/UQCRFS1/COX8C/MAPK9/NDUFV2/COX4I2/PIK3R1/COL3A1/PDK4/NDUFAB1/TGFB2/GAPDH/PLCB1/COX7A1/NDUFS6/NDUFV1/IRS1/CPT2/NDUFC1/CYBA/NDUFS5/NDUFS7/RYR2/PRKCZ/PLCB4/CTSD/INSR/NCF1/RAC2/COX6A1/COX6C/RELA/PDHB/AGTR1/PLCB2/NDUFS1/NDUFA4L2/COX6B1/PIK3R3/PARP1/UQCRQ/PLCB3/NDUFA11/TGFBR1/MAPK14/MMP2/PDK2/PIK3CB/SDHA/AGER/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/GSR/NDUFB5/NDUFA6/SMAD3/GYS1/MTOR/NDUFA8/NDUFB1/COX5A/PRKCB/NDUFB2/SDHC	104
KEGG	hsa03010	Ribosome	78/5183	158/8144	0.9999	1	0.7532	RPL13A/RPL3/RPS11/RPL23A/RPS3A/RPL8/RPL7A/RPS2/RPL3L/RPS18/RPL31/RPS15A/RPLP2/RPL18A/RPS12/MRPL34/RPL15/RPL32/RPL6/MRPS6/RPS3/RPL27A/RPSA/RPS28/RPS6/RPS9/RPL21/RPS15/RPL5/RPL35A/RPS13/RPL14/RPL27/MRPS14/RPS4X/RPL10L/RPL17/MRPL16/MRPL15/RPLP1/RPS29/RPS24/MRPL33/RPL23/RPL13/MRPL9/RPL22L1/MRPL35/RPS10/RPL35/MRPL17/RPS8/RPL26/MRPS11/MRPS15/MRPS10/MRPL4/MRPL32/MRPS18C/RPL38/RPL24/RPS4Y1/RSL24D1/RPL29/MRPL20/RPL36AL/MRPL10/MRPS2/MRPS5/RPL37/RPS7/RPL26L1/MRPL13/RPS27L/MRPL18/MRPS7/MRPS16/MRPL30	78
KEGG	hsa03013	Nucleocytoplasmic transport	50/5183	108/8144	0.9999	1	0.7532	XPO7/IPO9/NXF1/NUP210/NUP43/THOC7/ACIN1/IPO5/POM121/EIF4A3/POM121C/TMEM33/NUP93/NUP62/EEF1A1/KPNA7/NUP107/SENP2/XPO4/SUMO4/UPF3A/IPO11/KPNB1/UPF1/SUMO3/POM121L2/TNPO1/IPO13/RANBP2/DDX19A/EEF1A2/NCBP1/DDX19B/KPNA4/AHCTF1/SEC13/RAN/KPNA6/NUP54/TNPO2/UBE2I/SUMO2/NUP35/GLE1/RANBP17/IPO7/XPO5/XPO1/NUP160/THOC1	50
KEGG	hsa05168	Herpes simplex virus 1 infection	272/5183	495/8144	1	1	0.7532	FASLG/LTA/CALR/PIK3CD/IL1B/TNF/HLA-E/IFNG/IFNGR2/ZNF337/IKBKE/PILRA/ITGA5/ZNF124/TAP1/CCL5/JAK1/PILRB/NXF1/TNFSF14/ZNF556/POU2F1/SYK/BCL2L1/HLA-DMB/ZNF454/ZNF320/IFNA7/TNFRSF1A/NFKBIA/ZNF705A/ZNF471/ZNF677/ZNF311/ZFP28/ZNF589/ZNF667/BST2/HLA-F/TAP2/ZNF300/ZNF611/ZNF484/TP53/NFKB1/ZNF605/ITGB3/ZNF107/ZNF610/ZNF214/ZNF433/OAS2/ZNF317/HLA-DOA/ZNF177/ZNF676/ZNF440/ZNF354C/ZNF267/ZNF404/FADD/IFNA8/BIRC2/IL12B/ZNF205/ZNF705D/ZNF735/ZNF792/AKT2/CD74/CASP8/HLA-B/PIK3R2/ZNF418/ZNF615/ZNF195/IRAK4/ZNF492/ZNF135/ZNF713/ZNF93/ZNF658/ZNF415/HLA-DQA1/ZNF343/ZNF549/ZNF641/HLA-DRA/ZNF470/TRAF6/TRAF5/ZNF528/IRF9/ZNF33A/ZNF689/TSC2/C5/ZNF331/ZNF582/SP100/PIK3R1/ZNF439/ZNF565/ZNF552/EIF4EBP1/RNASEL/ZNF790/ZNF7/ZNF530/CASP3/ZNF20/ZFP37/TSC1/ZNF282/ZNF559/B2M/ZNF517/ZNF250/ZNF716/ZNF551/CASP9/ZNF607/ZNF780A/ZNF222/ZNF560/ZNF114/ZNF707/CYCS/ZNF45/ZNF480/ZNF229/TICAM1/ZNF350/ZNF441/ZNF534/ZIK1/ZNF77/ZNF354B/ZNF442/ZNF587/BIRC3/HLA-DQA2/ZNF793/ZNF783/ZNF419/RHEB/ZNF606/ZNF175/ZNF514/ZNF567/ZNF416/POU2F3/ZNF709/ZNF766/MAVS/ZNF600/ZNF25/BCL2/ZNF785/ZNF141/ZNF584/ZNF662/ZNF558/TLR2/STAT1/ZNF540/ZNF34/EIF2AK2/EIF2AK3/TLR9/ZNF578/ZNF208/ZNF782/ZNF160/ZNF101/ZNF479/ZNF679/ZNF519/ZNF189/HLA-DPB1/RELA/HLA-DOB/ZNF227/ZNF3/ZNF417/ZNF577/ZFP14/ZNF181/ZNF682/HLA-DMA/ZNF180/ZNF763/ZNF563/ZNF700/ZNF675/PIK3R3/C3/ZNF773/EIF2AK4/POU2F2/ZNF157/RBAK/ZNF805/SRPK1/ZNF768/ZNF99/ZNF169/ZNF98/ZNF813/IFNA4/ZNF527/IFNA14/ZNF564/ZNF680/ZNF230/ZNF823/ZNF234/ZNF154/ZNF570/ZNF324B/ZNF324/ZNF721/TBK1/PIK3CB/CCL2/OAS1/ZNF546/ZIM3/ZNF562/ZNF547/ZNF845/ZNF665/ZNF85/ZNF420/ZNF550/ZNF10/ZNF211/ZNF623/ZNF347/ZNF746/ZNF701/TAPBP/ZNF624/EIF2B3/TRAF3/MTOR/ZNF764/ZNF688/IFNAR2/ZNF221/ZNF699/ZNF620/IRF3/ZNF302/ZNF334/ZNF529/ZFP92/ZNF43/BID/ZNF599/ZNF44/ZNF614/ZNF382/ZNF333/ZNF814/ZNF225/ZNF304/ZNF136/ZNF155/ZNF585B/ZFP30/ZNF853	272
KEGG	hsa05012	Parkinson disease	137/5183	266/8144	1	1	0.7532	ADORA2A/XBP1/VDAC2/NDUFS8/NDUFS2/SLC18A1/CALML3/CALML6/ITPR1/CALML4/BCL2L1/UBA7/CALML5/KLC2/TH/SLC25A31/CAMK2A/GNAI3/SLC18A2/SNCA/TP53/PRKACA/NDUFB6/CAMK2B/SLC39A13/COX6B2/ADCY5/NDUFA7/CAMK2G/TUBB/NDUFB10/NDUFA5/MAPK10/PSMD13/PSMB7/COX7B2/NFE2L2/TUBA3C/UBB/UBE2L6/DDIT3/NDUFB8/ITPR2/UQCRFS1/PSMC2/MAP3K5/SLC39A11/PLCG1/COX8C/PSMD1/LRRK2/MAPK9/TUBA3E/NDUFV2/COX4I2/UCHL1/KIF5B/TUBA4A/SLC6A3/PSMC6/TUBA1A/PSMB4/CASP3/CALM1/NDUFAB1/CASP9/TUBB3/SLC39A1/CYCS/TUBA3D/COX7A1/UBC/NDUFS6/NDUFV1/PSMC4/CALM2/PSMD2/PSMA4/NDUFC1/PSMC5/NDUFS5/NDUFS7/GNAI1/TXN2/SLC11A2/EIF2AK3/TUBB8/TUBA8/PSMD14/SLC39A4/KIF5C/COX6A1/TUBB2A/COX6C/TUBA1B/KLC4/NDUFS1/NDUFA4L2/SOD1/PINK1/SLC39A12/SLC39A14/COX6B1/PRKACB/DRD1/PSMB5/PSMB2/GNAS/UQCRQ/NDUFA11/PSMD8/PSMB6/PSMD7/KLC1/SDHA/PSMD12/SDHB/NDUFA10/CYC1/COX6A2/HSPA5/UQCRHL/SLC39A9/PSMD6/NDUFB5/NDUFA6/CALM3/NDUFA8/NDUFB1/COX5A/ATF6/SLC39A10/NDUFB2/DRD2/ATF4/TUBA1C/SDHC	137
KEGG	hsa05014	Amyotrophic lateral sclerosis	194/5183	364/8144	1	1	0.7532	TNF/XBP1/DNAH3/NDUFS8/NDUFS2/DCTN2/ACTB/GPX3/NXF1/BCL2L1/NEFH/UBQLN3/NUP210/GRIA1/DNAH8/KLC2/TNFRSF1A/SQSTM1/NUP43/DNAH17/GPX6/DNAH10/TP53/CASP1/ATXN2/NDUFB6/POM121/NEFM/GRIA2/COX6B2/NEFL/MATR3/NDUFA7/NRG3/TUBB/POM121C/NDUFB10/NDUFA5/RAB1A/RAC1/PSMD13/PSMB7/NUP93/COX7B2/MAPK12/SETX/SPG11/NUP62/RB1CC1/TUBA3C/PRPH/DDIT3/NDUFB8/UQCRFS1/PFN2/PSMC2/TNFRSF1B/MAP3K5/DNAH2/NRG4/COX8C/PSMD1/TUBA3E/NDUFV2/COX4I2/KIF5B/TUBA4A/HNRNPA2B1/NUP107/GRIN2B/MAP1LC3B/PSMC6/ACTR1A/TUBA1A/VAPB/PSMB4/CASP3/MAP2K6/NDUFAB1/CASP9/TUBB3/HNRNPA3/DNAH5/GRIN2C/CYCS/TUBA3D/COX7A1/NDUFS6/NDUFV1/DCTN6/PSMC4/OPTN/DNAL1/DCTN3/DERL1/ATG2B/PSMD2/GPX2/PSMA4/NDUFC1/MAP1LC3A/WIPI1/PPP3R1/VCP/PPP3CA/PFN1/POM121L2/PSMC5/NDUFS5/BCL2/PFN4/NDUFS7/EIF2AK3/TUBB8/GRIN2A/DNAI2/TUBA8/PSMD14/RANBP2/KIF5C/COX6A1/TUBB2A/DCTN4/COX6C/DNAH12/TUBA1B/KLC4/NDUFS1/NCBP1/NDUFA4L2/AMBRA1/SOD1/PINK1/PPP3CC/NOS2/COX6B1/DNAI1/PPP3CB/PSMB5/PSMB2/UQCRQ/GPX5/UBQLN4/FUS/NDUFA11/GPX1/PSMD8/SEC13/MAPK14/GPX8/SLC1A2/PSMB6/TBK1/PSMD7/MAP2K3/KLC1/SDHA/PSMD12/NUP54/SDHB/NDUFA10/NUP35/CYC1/COX6A2/HSPA5/UQCRHL/DNAH11/PSMD6/NDUFB5/NDUFA6/PPP3R2/MTOR/NDUFA8/NDUFB1/COX5A/ATF6/GLE1/ALS2/NOS1/NDUFB2/BID/ACTR10/ATG2A/DNAL4/ATF4/CCS/NUP160/ATXN2L/MAP1LC3B2/DCTN1/TUBA1C/UBQLN1/SDHC/ACTG1	194
KEGG	hsa00190	Oxidative phosphorylation	62/5183	134/8144	1	1	0.7532	ATP6V0E2/NDUFS8/NDUFS2/ATP6V0A1/PPA2/ATP6V0D2/NDUFB6/COX6B2/NDUFA7/ATP4B/NDUFB10/NDUFA5/ATP6V0A4/COX7B2/LHPP/ATP6V1B1/ATP6V1B2/NDUFB8/UQCRFS1/ATP6V1C1/ATP6V1G3/COX8C/ATP6V0D1/NDUFV2/COX4I2/ATP6V1H/NDUFAB1/CYCS/COX7A1/NDUFS6/NDUFV1/NDUFC1/ATP12A/NDUFS5/NDUFS7/COX6A1/COX6C/NDUFS1/ATP6V1E1/NDUFA4L2/ATP6V0E1/ATP6V1D/COX6B1/ATP6V1F/UQCRQ/NDUFA11/TCIRG1/SDHA/SDHB/NDUFA10/CYC1/COX6A2/UQCRHL/NDUFB5/NDUFA6/NDUFA8/NDUFB1/COX5A/ATP4A/COX10/NDUFB2/SDHC	62
KEGG	hsa05203	Viral carcinogenesis	101/5183	204/8144	1	1	0.7532	LTBR/PIK3CD/HLA-E/YWHAG/CCR8/EGR3/TRAF1/JAK1/CREB3L2/STAT5A/SYK/MAPK3/RBL1/HPN/CREB3L4/CDKN2B/CCND2/NFKBIA/STAT3/CDC42/CDKN1A/DLG1/HLA-F/HDAC5/GRB2/TP53/NFKB1/GSN/PRKACA/YWHAZ/ATP6V0D2/CCR5/UBE3A/IL6ST/CDKN2A/CREB5/GTF2E2/CCNA1/RAC1/CASP8/HLA-B/PIK3R2/CDK6/EP300/NRAS/MAPK1/TRAF5/ATP6V0D1/IRF9/LYN/CCR3/HDAC1/SP100/PIK3R1/HRAS/ATF2/HDAC7/CASP3/CREB3L3/KRAS/MDM2/HDAC3/MAPKAPK2/CREB3/REL/USP7/CDK2/PMAIP1/EIF2AK2/CDC20/GTF2E1/CCND3/RELA/HDAC10/PRKACB/PIK3R3/C3/GTF2A1L/GTF2A2/VAC14/NFKB2/CREBBP/PIK3CB/PXN/TBPL1/HDAC2/CCNE1/POLB/STAT5B/RASA2/TRAF3/RBL2/MAD1L1/IRF3/CDKN1B/RB1/SCRIB/KAT2B/CCR4/ATF4/CREB1	101
KEGG	hsa03040	Spliceosome	66/5183	147/8144	1	1	0.7532	SF3B1/CRNKL1/SNRPB2/HSPA8/PPIE/SF3B3/DHX16/SNRNP70/HNRNPC/ACIN1/LSM4/DHX15/TRA2B/EIF4A3/CCDC12/CDC40/PRPF38B/TCERG1/SNRPF/PPIL1/DDX46/U2AF1L4/SART1/CHERP/U2AF2/PHF5A/PPIH/SNRNP200/SF3A2/HNRNPA3/PRPF19/HNRNPM/SNRPG/DDX5/HSPA1A/HSPA2/SNRPB/HSPA1L/SF3A1/DDX23/PRPF38A/NCBP1/PRPF40B/WBP11/RBM22/FUS/CDC5L/XAB2/CWC15/SF3B5/PCBP1/SF3A3/DHX38/PUF60/PRPF31/USP39/LSM2/SNRPD3/LSM6/SNRPD2/PRPF6/RBM25/LSM3/THOC1/SNRNP40/RBM17	66
KEGG	hsa04613	Neutrophil extracellular trap formation	85/5183	190/8144	1	1	0.7532	AZU1/TLR4/MPO/CTSG/ITGAL/ELANE/PIK3CD/VDAC2/FCGR2A/ACTB/SYK/MAPK3/FGG/FPR1/FCGR1A/C5AR1/SIGLEC9/SLC25A31/NCF4/HDAC5/NFKB1/FGA/NCF2/CASP1/CR1/ITGB3/ITGAM/HAT1/FPR3/RAC1/AKT2/MAPK12/PIK3R2/CASP4/ITGB2/PADI4/FCGR3B/GP1BA/PLCG1/MAPK1/ATG7/C5/HDAC1/GSDMD/MAP2K2/PIK3R1/FCGR3A/RAF1/HDAC7/FGB/PLCB1/CLCN3/HDAC3/CYBA/MAP2K1/TLR2/PLCB4/NCF1/RAC2/RELA/HDAC10/PLCB2/HMGB1/ITGA2B/PIK3R3/C3/PLCB3/FPR2/AQP9/PLCG2/MAPK14/CLEC7A/PIK3CB/HDAC2/TLR7/AGER/TLR8/SELPLG/MTOR/CLCN5/PRKCB/CAMP/CR1L/VWF/ACTG1	85
KEGG	hsa05034	Alcoholism	83/5183	187/8144	1	1	0.7532	ADORA2A/GNGT2/DDC/SHC1/SLC18A1/CALML3/GNB3/SLC29A1/CREB3L2/CALML6/CALML4/MAPK3/ADORA2B/CREB3L4/CAMKK1/CALML5/TH/GNG11/GNAO1/GNAI3/SLC18A2/HDAC5/GRB2/PRKACA/GRIN3A/ADCY5/HAT1/SHC2/CREB5/CAMKK2/SHC4/NRAS/MAPK1/GNGT1/PPP1R1B/HDAC1/GNG4/SLC6A3/HRAS/RAF1/ATF2/GRIN2B/PDYN/HDAC7/CALM1/CREB3L3/KRAS/GRIN2C/GNB4/BDNF/HDAC3/CALM2/CREB3/GNG2/MAP2K1/GNAI1/GNG7/SLC29A3/GRIN3B/GRIN2A/GNG8/PKIA/NTRK2/HDAC10/PRKACB/DRD1/GNAS/SOS2/GNG3/HDAC2/FOSB/GNB1/GNG5/CALM3/BRAF/SLC29A2/GNG10/DRD2/SOS1/ATF4/NPY/CREB1/CAMK4	83
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	35/5183	109/8144	1	1	0.7532	RIOK1/POP4/NXF1/WDR43/FBLL1/POP1/TBL3/UTP14C/RPP25/NOP56/NOP10/IMP4/WDR75/TCOF1/GNL3/SPATA5/RIOK2/MPHOSPH10/CSNK2A1/WDR36/CSNK2B/CSNK2A2/EIF6/RPP30/RAN/RMRP/NOB1/NVL/REXO1/EMG1/RPP40/POP7/NAT10/PWP2/XPO1	35
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	11/5183	66/8144	1	1	0.7532	LARS2/AARS2/EARS2/NARS2/TARS2/PSTK/FARSA/WARS2/VARS2/IARS2/CARS2	11
KEGG	hsa05322	Systemic lupus erythematosus	41/5183	136/8144	1	1	0.7532	CD28/CTSG/ELANE/IL10/TNF/IFNG/FCGR2A/HLA-DMB/C1QB/FCGR1A/C1QA/C9/C2/HLA-DOA/C8B/C7/C6/C4A/C4B/FCGR3B/C8A/HLA-DQA1/CD40/HLA-DRA/C5/C1QC/FCGR3A/GRIN2B/HLA-DQA2/TRIM21/SNRPB/GRIN2A/C1R/C8G/HLA-DPB1/HLA-DOB/HLA-DMA/C3/CD80/CD40LG/SNRPD3	41