ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05332 Graft-versus-host disease 3/73 42/8144 0.006175 0.7372 0.7372 IL2/IL1A/KLRC1 3 KEGG hsa04151 PI3K-Akt signaling pathway 8/73 354/8144 0.01346 0.7372 0.7372 SGK2/TEK/IRS1/COL9A1/IL2/PHLPP2/IL2RB/SYK 8 KEGG hsa04974 Protein digestion and absorption 4/73 103/8144 0.01349 0.7372 0.7372 PGA5/COL9A1/MEP1A/COL17A1 4 KEGG hsa04612 Antigen processing and presentation 3/73 78/8144 0.03257 0.8498 0.8498 CD74/KLRC4/KLRC1 3 KEGG hsa04940 Type I diabetes mellitus 2/73 43/8144 0.05653 0.8498 0.8498 IL2/IL1A 2 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 3/73 100/8144 0.06032 0.8498 0.8498 IL2/CCL21/IL2RB 3 KEGG hsa04064 NF-kappa B signaling pathway 3/73 104/8144 0.06626 0.8498 0.8498 GADD45G/CCL21/SYK 3 KEGG hsa04979 Cholesterol metabolism 2/73 50/8144 0.07371 0.8498 0.8498 APOC2/ANGPTL3 2 KEGG hsa05202 Transcriptional misregulation in cancer 4/73 193/8144 0.09449 0.8498 0.8498 HHEX/GADD45G/IL2RB/FEV 4 KEGG hsa05217 Basal cell carcinoma 2/73 63/8144 0.1092 0.8498 0.8498 FZD6/GADD45G 2 KEGG hsa05203 Viral carcinogenesis 4/73 204/8144 0.11 0.8498 0.8498 ACTN1/PMAIP1/HDAC9/SYK 4 KEGG hsa04068 FoxO signaling pathway 3/73 131/8144 0.1127 0.8498 0.8498 SGK2/IRS1/GADD45G 3 KEGG hsa04650 Natural killer cell mediated cytotoxicity 3/73 131/8144 0.1127 0.8498 0.8498 SH3BP2/KLRC1/SYK 3 KEGG hsa05321 Inflammatory bowel disease 2/73 65/8144 0.115 0.8498 0.8498 IL2/IL1A 2 KEGG hsa04060 Cytokine-cytokine receptor interaction 5/73 295/8144 0.1243 0.8498 0.8498 IL2/CNTF/IL1A/CCL21/IL2RB 5 KEGG hsa05162 Measles 3/73 139/8144 0.1284 0.8498 0.8498 IL2/IL1A/IL2RB 3 KEGG hsa04115 p53 signaling pathway 2/73 73/8144 0.139 0.8498 0.8498 GADD45G/PMAIP1 2 KEGG hsa00120 Primary bile acid biosynthesis 1/73 17/8144 0.1421 0.8498 0.8498 ACOX2 1 KEGG hsa05206 MicroRNAs in cancer 5/73 310/8144 0.1444 0.8498 0.8498 FOXP1/IRS1/TIMP3/MIR181A1/MIR181B1 5 KEGG hsa05212 Pancreatic cancer 2/73 76/8144 0.1483 0.8498 0.8498 GADD45G/ARHGEF6 2 KEGG hsa04146 Peroxisome 2/73 82/8144 0.1671 0.8498 0.8498 ACOX2/XDH 2 KEGG hsa04630 JAK-STAT signaling pathway 3/73 162/8144 0.1772 0.8498 0.8498 IL2/CNTF/IL2RB 3 KEGG hsa00340 Histidine metabolism 1/73 22/8144 0.1799 0.8498 0.8498 ALDH7A1 1 KEGG hsa05210 Colorectal cancer 2/73 86/8144 0.1799 0.8498 0.8498 GADD45G/PMAIP1 2 KEGG hsa04614 Renin-angiotensin system 1/73 23/8144 0.1873 0.8498 0.8498 CTSG 1 KEGG hsa04530 Tight junction 3/73 169/8144 0.193 0.8498 0.8498 AMOTL1/ACTN1/CLDN20 3 KEGG hsa04658 Th1 and Th2 cell differentiation 2/73 92/8144 0.1994 0.8498 0.8498 IL2/IL2RB 2 KEGG hsa05323 Rheumatoid arthritis 2/73 93/8144 0.2027 0.8498 0.8498 TEK/IL1A 2 KEGG hsa04950 Maturity onset diabetes of the young 1/73 26/8144 0.209 0.8498 0.8498 HHEX 1 KEGG hsa05152 Tuberculosis 3/73 180/8144 0.2185 0.8498 0.8498 CD74/IL1A/SYK 3 KEGG hsa04080 Neuroactive ligand-receptor interaction 5/73 362/8144 0.2236 0.8498 0.8498 CHRNA3/CTSG/GAL/MC3R/GNRH1 5 KEGG hsa04916 Melanogenesis 2/73 101/8144 0.2291 0.8498 0.8498 FZD6/TYR 2 KEGG hsa05146 Amoebiasis 2/73 102/8144 0.2324 0.8498 0.8498 CTSG/ACTN1 2 KEGG hsa00053 Ascorbate and aldarate metabolism 1/73 30/8144 0.2371 0.8498 0.8498 ALDH7A1 1 KEGG hsa04625 C-type lectin receptor signaling pathway 2/73 104/8144 0.239 0.8498 0.8498 IL2/SYK 2 KEGG hsa04613 Neutrophil extracellular trap formation 3/73 190/8144 0.2423 0.8498 0.8498 CTSG/HDAC9/SYK 3 KEGG hsa00410 beta-Alanine metabolism 1/73 31/8144 0.2439 0.8498 0.8498 ALDH7A1 1 KEGG hsa04215 Apoptosis - multiple species 1/73 32/8144 0.2507 0.8498 0.8498 PMAIP1 1 KEGG hsa04659 Th17 cell differentiation 2/73 108/8144 0.2523 0.8498 0.8498 IL2/IL2RB 2 KEGG hsa04670 Leukocyte transendothelial migration 2/73 114/8144 0.2723 0.8498 0.8498 ACTN1/CLDN20 2 KEGG hsa00350 Tyrosine metabolism 1/73 36/8144 0.2774 0.8498 0.8498 TYR 1 KEGG hsa03030 DNA replication 1/73 36/8144 0.2774 0.8498 0.8498 RNASEH2B 1 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 1/73 37/8144 0.2839 0.8498 0.8498 IRS1 1 KEGG hsa05216 Thyroid cancer 1/73 37/8144 0.2839 0.8498 0.8498 GADD45G 1 KEGG hsa05330 Allograft rejection 1/73 38/8144 0.2903 0.8498 0.8498 IL2 1 KEGG hsa00260 Glycine, serine and threonine metabolism 1/73 40/8144 0.303 0.8498 0.8498 ALDH7A1 1 KEGG hsa03440 Homologous recombination 1/73 41/8144 0.3093 0.8498 0.8498 RAD54B 1 KEGG hsa05219 Bladder cancer 1/73 41/8144 0.3093 0.8498 0.8498 DAPK2 1 KEGG hsa04810 Regulation of actin cytoskeleton 3/73 218/8144 0.3106 0.8498 0.8498 ACTN1/ARHGEF6/INSRR 3 KEGG hsa00380 Tryptophan metabolism 1/73 42/8144 0.3155 0.8498 0.8498 ALDH7A1 1 KEGG hsa04380 Osteoclast differentiation 2/73 128/8144 0.3189 0.8498 0.8498 IL1A/SYK 2 KEGG hsa00071 Fatty acid degradation 1/73 43/8144 0.3217 0.8498 0.8498 ALDH7A1 1 KEGG hsa04930 Type II diabetes mellitus 1/73 46/8144 0.3399 0.8498 0.8498 IRS1 1 KEGG hsa04210 Apoptosis 2/73 136/8144 0.3452 0.8498 0.8498 GADD45G/PMAIP1 2 KEGG hsa05322 Systemic lupus erythematosus 2/73 136/8144 0.3452 0.8498 0.8498 CTSG/ACTN1 2 KEGG hsa00620 Pyruvate metabolism 1/73 47/8144 0.3458 0.8498 0.8498 ALDH7A1 1 KEGG hsa00280 Valine, leucine and isoleucine degradation 1/73 48/8144 0.3517 0.8498 0.8498 ALDH7A1 1 KEGG hsa04672 Intestinal immune network for IgA production 1/73 49/8144 0.3576 0.8498 0.8498 IL2 1 KEGG hsa04140 Autophagy - animal 2/73 141/8144 0.3615 0.8498 0.8498 IRS1/DAPK2 2 KEGG hsa00330 Arginine and proline metabolism 1/73 51/8144 0.3691 0.8498 0.8498 ALDH7A1 1 KEGG hsa05320 Autoimmune thyroid disease 1/73 53/8144 0.3804 0.8498 0.8498 IL2 1 KEGG hsa05224 Breast cancer 2/73 147/8144 0.3809 0.8498 0.8498 FZD6/GADD45G 2 KEGG hsa05226 Gastric cancer 2/73 149/8144 0.3873 0.8498 0.8498 FZD6/GADD45G 2 KEGG hsa04923 Regulation of lipolysis in adipocytes 1/73 56/8144 0.3971 0.8498 0.8498 IRS1 1 KEGG hsa04932 Non-alcoholic fatty liver disease 2/73 155/8144 0.4064 0.8498 0.8498 IRS1/IL1A 2 KEGG hsa05213 Endometrial cancer 1/73 58/8144 0.4079 0.8498 0.8498 GADD45G 1 KEGG hsa04150 mTOR signaling pathway 2/73 156/8144 0.4095 0.8498 0.8498 FZD6/IRS1 2 KEGG hsa04218 Cellular senescence 2/73 156/8144 0.4095 0.8498 0.8498 IL1A/GADD45G 2 KEGG hsa00561 Glycerolipid metabolism 1/73 61/8144 0.4238 0.8498 0.8498 ALDH7A1 1 KEGG hsa04213 Longevity regulating pathway - multiple species 1/73 62/8144 0.429 0.8498 0.8498 IRS1 1 KEGG hsa00310 Lysine degradation 1/73 63/8144 0.4342 0.8498 0.8498 ALDH7A1 1 KEGG hsa03250 Viral life cycle - HIV-1 1/73 63/8144 0.4342 0.8498 0.8498 ELL2 1 KEGG hsa04929 GnRH secretion 1/73 64/8144 0.4393 0.8498 0.8498 GNRH1 1 KEGG hsa04310 Wnt signaling pathway 2/73 167/8144 0.4436 0.8498 0.8498 FZD6/LGR6 2 KEGG hsa05225 Hepatocellular carcinoma 2/73 168/8144 0.4466 0.8498 0.8498 FZD6/GADD45G 2 KEGG hsa00010 Glycolysis / Gluconeogenesis 1/73 67/8144 0.4543 0.8498 0.8498 ALDH7A1 1 KEGG hsa04664 Fc epsilon RI signaling pathway 1/73 68/8144 0.4593 0.8498 0.8498 SYK 1 KEGG hsa04920 Adipocytokine signaling pathway 1/73 69/8144 0.4642 0.8498 0.8498 IRS1 1 KEGG hsa04520 Adherens junction 1/73 71/8144 0.4738 0.8498 0.8498 ACTN1 1 KEGG hsa04137 Mitophagy - animal 1/73 72/8144 0.4786 0.8498 0.8498 RHOT1 1 KEGG hsa05218 Melanoma 1/73 72/8144 0.4786 0.8498 0.8498 GADD45G 1 KEGG hsa05223 Non-small cell lung cancer 1/73 72/8144 0.4786 0.8498 0.8498 GADD45G 1 KEGG hsa00562 Inositol phosphate metabolism 1/73 73/8144 0.4833 0.8498 0.8498 PIK3C2A 1 KEGG hsa01524 Platinum drug resistance 1/73 73/8144 0.4833 0.8498 0.8498 PMAIP1 1 KEGG hsa04360 Axon guidance 2/73 182/8144 0.4883 0.8498 0.8498 PLXNB1/SRGAP2 2 KEGG hsa03320 PPAR signaling pathway 1/73 75/8144 0.4926 0.8498 0.8498 ACOX2 1 KEGG hsa05214 Glioma 1/73 75/8144 0.4926 0.8498 0.8498 GADD45G 1 KEGG hsa04010 MAPK signaling pathway 3/73 294/8144 0.494 0.8498 0.8498 TEK/IL1A/GADD45G 3 KEGG hsa04971 Gastric acid secretion 1/73 76/8144 0.4972 0.8498 0.8498 KCNJ15 1 KEGG hsa05133 Pertussis 1/73 76/8144 0.4972 0.8498 0.8498 IL1A 1 KEGG hsa05220 Chronic myeloid leukemia 1/73 76/8144 0.4972 0.8498 0.8498 GADD45G 1 KEGG hsa05140 Leishmaniasis 1/73 77/8144 0.5017 0.8498 0.8498 IL1A 1 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 1/73 77/8144 0.5017 0.8498 0.8498 DSG2 1 KEGG hsa00983 Drug metabolism - other enzymes 1/73 80/8144 0.5151 0.8498 0.8498 XDH 1 KEGG hsa04662 B cell receptor signaling pathway 1/73 82/8144 0.5239 0.8498 0.8498 SYK 1 KEGG hsa01232 Nucleotide metabolism 1/73 85/8144 0.5367 0.8498 0.8498 XDH 1 KEGG hsa04742 Taste transduction 1/73 86/8144 0.5409 0.8498 0.8498 TAS2R30 1 KEGG hsa04510 Focal adhesion 2/73 201/8144 0.5417 0.8498 0.8498 COL9A1/ACTN1 2 KEGG hsa05169 Epstein-Barr virus infection 2/73 202/8144 0.5444 0.8498 0.8498 GADD45G/SYK 2 KEGG hsa04512 ECM-receptor interaction 1/73 88/8144 0.5492 0.8498 0.8498 COL9A1 1 KEGG hsa05205 Proteoglycans in cancer 2/73 205/8144 0.5525 0.8498 0.8498 FZD6/TIMP3 2 KEGG hsa04211 Longevity regulating pathway 1/73 89/8144 0.5532 0.8498 0.8498 IRS1 1 KEGG hsa04740 Olfactory transduction 4/73 440/8144 0.5615 0.8498 0.8498 OR52E4/OR56B1/OR10AD1/OR2T3 4 KEGG hsa05222 Small cell lung cancer 1/73 92/8144 0.5653 0.8498 0.8498 GADD45G 1 KEGG hsa04912 GnRH signaling pathway 1/73 93/8144 0.5692 0.8498 0.8498 GNRH1 1 KEGG hsa04970 Salivary secretion 1/73 93/8144 0.5692 0.8498 0.8498 MUC7 1 KEGG hsa03015 mRNA surveillance pathway 1/73 97/8144 0.5846 0.8498 0.8498 GSPT1 1 KEGG hsa04070 Phosphatidylinositol signaling system 1/73 97/8144 0.5846 0.8498 0.8498 PIK3C2A 1 KEGG hsa04666 Fc gamma R-mediated phagocytosis 1/73 97/8144 0.5846 0.8498 0.8498 SYK 1 KEGG hsa05215 Prostate cancer 1/73 97/8144 0.5846 0.8498 0.8498 INSRR 1 KEGG hsa00564 Glycerophospholipid metabolism 1/73 98/8144 0.5884 0.8498 0.8498 ETNK1 1 KEGG hsa04640 Hematopoietic cell lineage 1/73 99/8144 0.5921 0.8498 0.8498 IL1A 1 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 1/73 100/8144 0.5958 0.8498 0.8498 IL1A 1 KEGG hsa05166 Human T-cell leukemia virus 1 infection 2/73 222/8144 0.5962 0.8498 0.8498 IL2/IL2RB 2 KEGG hsa05142 Chagas disease 1/73 102/8144 0.6031 0.8498 0.8498 IL2 1 KEGG hsa04660 T cell receptor signaling pathway 1/73 104/8144 0.6103 0.8498 0.8498 IL2 1 KEGG hsa05171 Coronavirus disease - COVID-19 2/73 232/8144 0.6204 0.8498 0.8498 IL2/SYK 2 KEGG hsa03013 Nucleocytoplasmic transport 1/73 108/8144 0.6243 0.8498 0.8498 RANBP17 1 KEGG hsa04931 Insulin resistance 1/73 108/8144 0.6243 0.8498 0.8498 IRS1 1 KEGG hsa04066 HIF-1 signaling pathway 1/73 109/8144 0.6277 0.8498 0.8498 TEK 1 KEGG hsa04725 Cholinergic synapse 1/73 113/8144 0.641 0.8498 0.8498 CHRNA3 1 KEGG hsa01200 Carbon metabolism 1/73 115/8144 0.6475 0.8498 0.8498 ESD 1 KEGG hsa04726 Serotonergic synapse 1/73 115/8144 0.6475 0.8498 0.8498 KCND2 1 KEGG hsa05131 Shigellosis 2/73 247/8144 0.6547 0.8498 0.8498 ACTN1/U2AF1L4 2 KEGG hsa05168 Herpes simplex virus 1 infection 4/73 495/8144 0.6558 0.8498 0.8498 CD74/SYK/ZNF479/ZNF714 4 KEGG hsa04722 Neurotrophin signaling pathway 1/73 119/8144 0.6602 0.8498 0.8498 IRS1 1 KEGG hsa04935 Growth hormone synthesis, secretion and action 1/73 119/8144 0.6602 0.8498 0.8498 IRS1 1 KEGG hsa04152 AMPK signaling pathway 1/73 120/8144 0.6633 0.8498 0.8498 IRS1 1 KEGG hsa04611 Platelet activation 1/73 124/8144 0.6754 0.8529 0.8529 SYK 1 KEGG hsa05010 Alzheimer disease 3/73 384/8144 0.6761 0.8529 0.8529 FZD6/IRS1/IL1A 3 KEGG hsa04110 Cell cycle 1/73 126/8144 0.6813 0.8529 0.8529 GADD45G 1 KEGG hsa00230 Purine metabolism 1/73 128/8144 0.687 0.8536 0.8536 XDH 1 KEGG hsa04142 Lysosome 1/73 132/8144 0.6983 0.8567 0.8567 CTSG 1 KEGG hsa04910 Insulin signaling pathway 1/73 137/8144 0.7118 0.8567 0.8567 IRS1 1 KEGG hsa05135 Yersinia infection 1/73 137/8144 0.7118 0.8567 0.8567 IL2 1 KEGG hsa05418 Fluid shear stress and atherosclerosis 1/73 139/8144 0.717 0.8567 0.8567 IL1A 1 KEGG hsa04120 Ubiquitin mediated proteolysis 1/73 142/8144 0.7247 0.8567 0.8567 UBE2QL1 1 KEGG hsa04936 Alcoholic liver disease 1/73 142/8144 0.7247 0.8567 0.8567 ALDH7A1 1 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 1/73 143/8144 0.7272 0.8567 0.8567 FZD6 1 KEGG hsa03040 Spliceosome 1/73 147/8144 0.737 0.8567 0.8567 U2AF1L4 1 KEGG hsa04072 Phospholipase D signaling pathway 1/73 148/8144 0.7394 0.8567 0.8567 SYK 1 KEGG hsa04514 Cell adhesion molecules 1/73 149/8144 0.7418 0.8567 0.8567 CLDN20 1 KEGG hsa04934 Cushing syndrome 1/73 155/8144 0.7556 0.8587 0.8587 FZD6 1 KEGG hsa04390 Hippo signaling pathway 1/73 157/8144 0.7601 0.8587 0.8587 FZD6 1 KEGG hsa05160 Hepatitis C 1/73 157/8144 0.7601 0.8587 0.8587 CLDN20 1 KEGG hsa04217 Necroptosis 1/73 159/8144 0.7644 0.8587 0.8587 IL1A 1 KEGG hsa04022 cGMP-PKG signaling pathway 1/73 167/8144 0.7811 0.8715 0.8715 IRS1 1 KEGG hsa05164 Influenza A 1/73 171/8144 0.789 0.8743 0.8743 IL1A 1 KEGG hsa05165 Human papillomavirus infection 2/73 331/8144 0.8034 0.8843 0.8843 FZD6/COL9A1 2 KEGG hsa04621 NOD-like receptor signaling pathway 1/73 184/8144 0.8128 0.8881 0.8881 NLRP7 1 KEGG hsa05034 Alcoholism 1/73 187/8144 0.8179 0.8881 0.8881 HDAC9 1 KEGG hsa04062 Chemokine signaling pathway 1/73 192/8144 0.8261 0.8881 0.8881 CCL21 1 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/73 194/8144 0.8293 0.8881 0.8881 SYK 1 KEGG hsa05130 Pathogenic Escherichia coli infection 1/73 197/8144 0.834 0.8881 0.8881 CLDN20 1 KEGG hsa05415 Diabetic cardiomyopathy 1/73 203/8144 0.8429 0.8919 0.8919 IRS1 1 KEGG hsa04015 Rap1 signaling pathway 1/73 210/8144 0.8528 0.8936 0.8936 TEK 1 KEGG hsa05207 Chemical carcinogenesis - receptor activation 1/73 212/8144 0.8555 0.8936 0.8936 CHRNA3 1 KEGG hsa04024 cAMP signaling pathway 1/73 221/8144 0.867 0.8999 0.8999 SOX9 1 KEGG hsa04014 Ras signaling pathway 1/73 232/8144 0.8799 0.9019 0.9019 TEK 1 KEGG hsa04714 Thermogenesis 1/73 232/8144 0.8799 0.9019 0.9019 KLB 1 KEGG hsa05132 Salmonella infection 1/73 249/8144 0.8974 0.9104 0.9104 PIK3C2A 1 KEGG hsa04144 Endocytosis 1/73 251/8144 0.8993 0.9104 0.9104 IL2RB 1 KEGG hsa05020 Prion disease 1/73 273/8144 0.9179 0.9236 0.9236 IL1A 1 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 2/73 476/8144 0.9327 0.9327 0.9327 FZD6/IL1A 2