ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05164 Influenza A 9/80 171/8144 4.147e-05 0.007174 0.006941 HLA-DRB5/RAB11B/RSAD2/SOCS3/OAS1/EIF2AK2/FASLG/IRF7/MX1 9 KEGG hsa05160 Hepatitis C 7/80 157/8144 0.0008459 0.06444 0.06234 RSAD2/SOCS3/OAS1/EIF2AK2/FASLG/IRF7/MX1 7 KEGG hsa04973 Carbohydrate digestion and absorption 4/80 47/8144 0.001117 0.06444 0.06234 TAS1R2/AMY1A/AMY1B/AMY1C 4 KEGG hsa04932 Non-alcoholic fatty liver disease 6/80 155/8144 0.004069 0.1734 0.1677 SOCS3/PRKAA1/FASLG/UQCRFS1/SDHA/SREBF1 6 KEGG hsa00500 Starch and sucrose metabolism 3/80 36/8144 0.005161 0.1734 0.1677 AMY1A/AMY1B/AMY1C 3 KEGG hsa05330 Allograft rejection 3/80 38/8144 0.006013 0.1734 0.1677 HLA-DRB5/PRF1/FASLG 3 KEGG hsa05332 Graft-versus-host disease 3/80 42/8144 0.007956 0.1837 0.1777 HLA-DRB5/PRF1/FASLG 3 KEGG hsa04940 Type I diabetes mellitus 3/80 43/8144 0.008493 0.1837 0.1777 HLA-DRB5/PRF1/FASLG 3 KEGG hsa05162 Measles 5/80 139/8144 0.01165 0.2239 0.2166 OAS1/EIF2AK2/FASLG/IRF7/MX1 5 KEGG hsa05320 Autoimmune thyroid disease 3/80 53/8144 0.01503 0.2601 0.2516 HLA-DRB5/PRF1/FASLG 3 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 2/80 26/8144 0.02659 0.4182 0.4046 PIGX/PIGY 2 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 2/80 30/8144 0.03471 0.5004 0.4841 GLUL/CAT 2 KEGG hsa04068 FoxO signaling pathway 4/80 131/8144 0.03961 0.5271 0.51 PRKAA1/FASLG/CAT/GABARAP 4 KEGG hsa04210 Apoptosis 4/80 136/8144 0.04445 0.5493 0.5314 PRF1/FASLG/DIABLO/DFFA 4 KEGG hsa04936 Alcoholic liver disease 4/80 142/8144 0.05068 0.5703 0.5518 PRKAA1/IL17RA/FASLG/SREBF1 4 KEGG hsa05168 Herpes simplex virus 1 infection 9/80 495/8144 0.05275 0.5703 0.5518 HLA-DRB5/SOCS3/OAS1/BST2/EIF2AK2/ZNF785/FASLG/IRF7/ZNF583 9 KEGG hsa04970 Salivary secretion 3/80 93/8144 0.06316 0.6427 0.6218 AMY1A/AMY1B/AMY1C 3 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 5/80 223/8144 0.06782 0.6518 0.6306 HGF/KEAP1/CAT/UQCRFS1/SDHA 5 KEGG hsa04972 Pancreatic secretion 3/80 102/8144 0.07858 0.7059 0.683 AMY1A/AMY1B/AMY1C 3 KEGG hsa04931 Insulin resistance 3/80 108/8144 0.08969 0.7059 0.683 SOCS3/PRKAA1/SREBF1 3 KEGG hsa00920 Sulfur metabolism 1/80 10/8144 0.09405 0.7059 0.683 PAPSS1 1 KEGG hsa00600 Sphingolipid metabolism 2/80 53/8144 0.09529 0.7059 0.683 GBA/ARSA 2 KEGG hsa04621 NOD-like receptor signaling pathway 4/80 184/8144 0.1067 0.7059 0.683 OAS1/IRF7/GSDMD/GABARAP 4 KEGG hsa04152 AMPK signaling pathway 3/80 120/8144 0.1137 0.7059 0.683 RAB11B/PRKAA1/SREBF1 3 KEGG hsa04330 Notch signaling pathway 2/80 59/8144 0.114 0.7059 0.683 DTX3L/DTX1 2 KEGG hsa05416 Viral myocarditis 2/80 60/8144 0.1172 0.7059 0.683 HLA-DRB5/PRF1 2 KEGG hsa04213 Longevity regulating pathway - multiple species 2/80 62/8144 0.1237 0.7059 0.683 PRKAA1/CAT 2 KEGG hsa03250 Viral life cycle - HIV-1 2/80 63/8144 0.127 0.7059 0.683 BST2/MX1 2 KEGG hsa05169 Epstein-Barr virus infection 4/80 202/8144 0.1368 0.7059 0.683 HLA-DRB5/OAS1/EIF2AK2/IRF7 4 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/80 15/8144 0.1377 0.7059 0.683 NAGA 1 KEGG hsa00730 Thiamine metabolism 1/80 15/8144 0.1377 0.7059 0.683 ALPL 1 KEGG hsa04142 Lysosome 3/80 132/8144 0.14 0.7059 0.683 GBA/NAGA/ARSA 3 KEGG hsa04920 Adipocytokine signaling pathway 2/80 69/8144 0.1471 0.7059 0.683 SOCS3/PRKAA1 2 KEGG hsa04910 Insulin signaling pathway 3/80 137/8144 0.1514 0.7059 0.683 SOCS3/PRKAA1/SREBF1 3 KEGG hsa00450 Selenocompound metabolism 1/80 17/8144 0.1546 0.7059 0.683 PAPSS1 1 KEGG hsa00910 Nitrogen metabolism 1/80 17/8144 0.1546 0.7059 0.683 GLUL 1 KEGG hsa05418 Fluid shear stress and atherosclerosis 3/80 139/8144 0.1561 0.7059 0.683 PIAS4/KEAP1/PRKAA1 3 KEGG hsa04140 Autophagy - animal 3/80 141/8144 0.1608 0.7059 0.683 PRKAA1/WDR41/GABARAP 3 KEGG hsa00511 Other glycan degradation 1/80 18/8144 0.163 0.7059 0.683 GBA 1 KEGG hsa04120 Ubiquitin mediated proteolysis 3/80 142/8144 0.1632 0.7059 0.683 SOCS3/PIAS4/KEAP1 3 KEGG hsa04612 Antigen processing and presentation 2/80 78/8144 0.1783 0.7194 0.696 HLA-DRB5/PSME1 2 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/80 20/8144 0.1794 0.7194 0.696 CHST14 1 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 7/80 476/8144 0.1857 0.7194 0.696 DNAH6/FASLG/CAT/WDR41/UQCRFS1/ATXN3/SDHA 7 KEGG hsa04145 Phagosome 3/80 152/8144 0.1876 0.7194 0.696 HLA-DRB5/RILP/COLEC11 3 KEGG hsa04146 Peroxisome 2/80 82/8144 0.1925 0.7194 0.696 PRDX5/CAT 2 KEGG hsa00220 Arginine biosynthesis 1/80 22/8144 0.1954 0.7194 0.696 GLUL 1 KEGG hsa00900 Terpenoid backbone biosynthesis 1/80 22/8144 0.1954 0.7194 0.696 ICMT 1 KEGG hsa04217 Necroptosis 3/80 159/8144 0.2051 0.7301 0.7063 EIF2AK2/GLUL/FASLG 3 KEGG hsa04742 Taste transduction 2/80 86/8144 0.2068 0.7301 0.7063 KCNK5/TAS1R2 2 KEGG hsa04211 Longevity regulating pathway 2/80 89/8144 0.2176 0.7382 0.7141 PRKAA1/CAT 2 KEGG hsa04727 GABAergic synapse 2/80 89/8144 0.2176 0.7382 0.7141 GLUL/GABARAP 2 KEGG hsa00790 Folate biosynthesis 1/80 26/8144 0.2267 0.7541 0.7296 ALPL 1 KEGG hsa05231 Choline metabolism in cancer 2/80 98/8144 0.2503 0.7694 0.7444 DGKE/SLC22A5 2 KEGG hsa00020 Citrate cycle (TCA cycle) 1/80 30/8144 0.2567 0.7694 0.7444 SDHA 1 KEGG hsa01523 Antifolate resistance 1/80 30/8144 0.2567 0.7694 0.7444 ABCG2 1 KEGG hsa04710 Circadian rhythm 1/80 31/8144 0.264 0.7694 0.7444 PRKAA1 1 KEGG hsa05310 Asthma 1/80 31/8144 0.264 0.7694 0.7444 HLA-DRB5 1 KEGG hsa05012 Parkinson disease 4/80 266/8144 0.2649 0.7694 0.7444 KEAP1/SLC39A14/UQCRFS1/SDHA 4 KEGG hsa05142 Chagas disease 2/80 102/8144 0.2649 0.7694 0.7444 GNA15/FASLG 2 KEGG hsa04136 Autophagy - other 1/80 32/8144 0.2713 0.7694 0.7444 GABARAP 1 KEGG hsa04215 Apoptosis - multiple species 1/80 32/8144 0.2713 0.7694 0.7444 DIABLO 1 KEGG hsa04130 SNARE interactions in vesicular transport 1/80 33/8144 0.2785 0.7771 0.7518 STX5 1 KEGG hsa05014 Amyotrophic lateral sclerosis 5/80 364/8144 0.2865 0.7869 0.7613 DNAH6/CAT/WDR41/UQCRFS1/SDHA 5 KEGG hsa00512 Mucin type O-glycan biosynthesis 1/80 36/8144 0.2996 0.7915 0.7658 GALNT3 1 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 1/80 37/8144 0.3065 0.7915 0.7658 GLUL 1 KEGG hsa01250 Biosynthesis of nucleotide sugars 1/80 37/8144 0.3065 0.7915 0.7658 UAP1 1 KEGG hsa05143 African trypanosomiasis 1/80 37/8144 0.3065 0.7915 0.7658 FASLG 1 KEGG hsa01200 Carbon metabolism 2/80 115/8144 0.3124 0.7947 0.7688 CAT/SDHA 2 KEGG hsa05203 Viral carcinogenesis 3/80 204/8144 0.3244 0.8132 0.7868 HDAC9/EIF2AK2/IRF7 3 KEGG hsa04216 Ferroptosis 1/80 41/8144 0.3335 0.8137 0.7872 SLC39A14 1 KEGG hsa00380 Tryptophan metabolism 1/80 42/8144 0.3401 0.8137 0.7872 CAT 1 KEGG hsa04962 Vasopressin-regulated water reabsorption 1/80 44/8144 0.3531 0.8137 0.7872 RAB11B 1 KEGG hsa02010 ABC transporters 1/80 45/8144 0.3595 0.8137 0.7872 ABCG2 1 KEGG hsa03050 Proteasome 1/80 46/8144 0.3658 0.8137 0.7872 PSME1 1 KEGG hsa04930 Type II diabetes mellitus 1/80 46/8144 0.3658 0.8137 0.7872 SOCS3 1 KEGG hsa04650 Natural killer cell mediated cytotoxicity 2/80 131/8144 0.3698 0.8137 0.7872 PRF1/FASLG 2 KEGG hsa00514 Other types of O-glycan biosynthesis 1/80 47/8144 0.372 0.8137 0.7872 GALNT3 1 KEGG hsa00190 Oxidative phosphorylation 2/80 134/8144 0.3804 0.8137 0.7872 UQCRFS1/SDHA 2 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 1/80 49/8144 0.3844 0.8137 0.7872 UAP1 1 KEGG hsa00565 Ether lipid metabolism 1/80 49/8144 0.3844 0.8137 0.7872 TMEM189 1 KEGG hsa04672 Intestinal immune network for IgA production 1/80 49/8144 0.3844 0.8137 0.7872 HLA-DRB5 1 KEGG hsa05144 Malaria 1/80 50/8144 0.3905 0.8137 0.7872 HGF 1 KEGG hsa00270 Cysteine and methionine metabolism 1/80 51/8144 0.3965 0.8137 0.7872 AHCYL1 1 KEGG hsa04714 Thermogenesis 3/80 232/8144 0.3998 0.8137 0.7872 PRKAA1/UQCRFS1/SDHA 3 KEGG hsa05171 Coronavirus disease - COVID-19 3/80 232/8144 0.3998 0.8137 0.7872 OAS1/EIF2AK2/MX1 3 KEGG hsa04978 Mineral absorption 1/80 60/8144 0.4481 0.8255 0.7986 MT2A 1 KEGG hsa04144 Endocytosis 3/80 251/8144 0.4498 0.8255 0.7986 RAB11B/VPS25/ARFGAP2 3 KEGG hsa00561 Glycerolipid metabolism 1/80 61/8144 0.4536 0.8255 0.7986 DGKE 1 KEGG hsa04150 mTOR signaling pathway 2/80 156/8144 0.4555 0.8255 0.7986 PRKAA1/DEPDC5 2 KEGG hsa00310 Lysine degradation 1/80 63/8144 0.4644 0.8255 0.7986 PLOD1 1 KEGG hsa04623 Cytosolic DNA-sensing pathway 1/80 63/8144 0.4644 0.8255 0.7986 IRF7 1 KEGG hsa04929 GnRH secretion 1/80 64/8144 0.4697 0.8255 0.7986 HCN3 1 KEGG hsa05321 Inflammatory bowel disease 1/80 65/8144 0.4749 0.8255 0.7986 HLA-DRB5 1 KEGG hsa04630 JAK-STAT signaling pathway 2/80 162/8144 0.4751 0.8255 0.7986 SOCS3/PIAS4 2 KEGG hsa05161 Hepatitis B 2/80 162/8144 0.4751 0.8255 0.7986 FASLG/IRF7 2 KEGG hsa04664 Fc epsilon RI signaling pathway 1/80 68/8144 0.4904 0.8255 0.7986 ALOX5AP 1 KEGG hsa05225 Hepatocellular carcinoma 2/80 168/8144 0.4943 0.8255 0.7986 HGF/KEAP1 2 KEGG hsa05211 Renal cell carcinoma 1/80 69/8144 0.4954 0.8255 0.7986 HGF 1 KEGG hsa04622 RIG-I-like receptor signaling pathway 1/80 70/8144 0.5004 0.8255 0.7986 IRF7 1 KEGG hsa04917 Prolactin signaling pathway 1/80 70/8144 0.5004 0.8255 0.7986 SOCS3 1 KEGG hsa04141 Protein processing in endoplasmic reticulum 2/80 171/8144 0.5037 0.8255 0.7986 EIF2AK2/ATXN3 2 KEGG hsa04137 Mitophagy - animal 1/80 72/8144 0.5103 0.8255 0.7986 GABARAP 1 KEGG hsa05218 Melanoma 1/80 72/8144 0.5103 0.8255 0.7986 HGF 1 KEGG hsa05223 Non-small cell lung cancer 1/80 72/8144 0.5103 0.8255 0.7986 HGF 1 KEGG hsa01524 Platinum drug resistance 1/80 73/8144 0.5151 0.8255 0.7986 FASLG 1 KEGG hsa01230 Biosynthesis of amino acids 1/80 75/8144 0.5247 0.8255 0.7986 GLUL 1 KEGG hsa03320 PPAR signaling pathway 1/80 75/8144 0.5247 0.8255 0.7986 PLIN2 1 KEGG hsa05010 Alzheimer disease 4/80 384/8144 0.5254 0.8255 0.7986 EIF2AK2/SLC39A14/UQCRFS1/SDHA 4 KEGG hsa05220 Chronic myeloid leukemia 1/80 76/8144 0.5294 0.8255 0.7986 BCR 1 KEGG hsa05140 Leishmaniasis 1/80 77/8144 0.5341 0.8255 0.7986 HLA-DRB5 1 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 1/80 79/8144 0.5433 0.8255 0.7986 HGF 1 KEGG hsa04613 Neutrophil extracellular trap formation 2/80 190/8144 0.5608 0.8255 0.7986 HDAC9/GSDMD 2 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 2/80 194/8144 0.5722 0.8255 0.7986 EIF2AK2/IRF7 2 KEGG hsa04260 Cardiac muscle contraction 1/80 87/8144 0.5783 0.8255 0.7986 UQCRFS1 1 KEGG hsa05016 Huntington disease 3/80 306/8144 0.5835 0.8255 0.7986 DNAH6/UQCRFS1/SDHA 3 KEGG hsa04976 Bile secretion 1/80 89/8144 0.5866 0.8255 0.7986 ABCG2 1 KEGG hsa05410 Hypertrophic cardiomyopathy 1/80 90/8144 0.5907 0.8255 0.7986 PRKAA1 1 KEGG hsa05206 MicroRNAs in cancer 3/80 310/8144 0.5925 0.8255 0.7986 MIR520E/MIR32/MIR181B1 3 KEGG hsa05415 Diabetic cardiomyopathy 2/80 203/8144 0.5971 0.8255 0.7986 UQCRFS1/SDHA 2 KEGG hsa04658 Th1 and Th2 cell differentiation 1/80 92/8144 0.5988 0.8255 0.7986 HLA-DRB5 1 KEGG hsa05205 Proteoglycans in cancer 2/80 205/8144 0.6025 0.8255 0.7986 HGF/FASLG 2 KEGG hsa05323 Rheumatoid arthritis 1/80 93/8144 0.6028 0.8255 0.7986 HLA-DRB5 1 KEGG hsa04657 IL-17 signaling pathway 1/80 94/8144 0.6068 0.8255 0.7986 IL17RA 1 KEGG hsa05150 Staphylococcus aureus infection 1/80 96/8144 0.6145 0.8255 0.7986 HLA-DRB5 1 KEGG hsa04070 Phosphatidylinositol signaling system 1/80 97/8144 0.6184 0.8255 0.7986 DGKE 1 KEGG hsa04713 Circadian entrainment 1/80 97/8144 0.6184 0.8255 0.7986 MTNR1B 1 KEGG hsa05170 Human immunodeficiency virus 1 infection 2/80 212/8144 0.6209 0.8255 0.7986 BST2/FASLG 2 KEGG hsa00564 Glycerophospholipid metabolism 1/80 98/8144 0.6222 0.8255 0.7986 DGKE 1 KEGG hsa04640 Hematopoietic cell lineage 1/80 99/8144 0.6259 0.8255 0.7986 HLA-DRB5 1 KEGG hsa05417 Lipid and atherosclerosis 2/80 215/8144 0.6286 0.8255 0.7986 FASLG/IRF7 2 KEGG hsa05146 Amoebiasis 1/80 102/8144 0.637 0.8255 0.7986 GNA15 1 KEGG hsa05165 Human papillomavirus infection 3/80 331/8144 0.6373 0.8255 0.7986 EIF2AK2/FASLG/MX1 3 KEGG hsa04974 Protein digestion and absorption 1/80 103/8144 0.6406 0.8255 0.7986 KCNK5 1 KEGG hsa04064 NF-kappa B signaling pathway 1/80 104/8144 0.6441 0.8255 0.7986 PIAS4 1 KEGG hsa04620 Toll-like receptor signaling pathway 1/80 104/8144 0.6441 0.8255 0.7986 IRF7 1 KEGG hsa04922 Glucagon signaling pathway 1/80 107/8144 0.6547 0.8277 0.8008 PRKAA1 1 KEGG hsa04659 Th17 cell differentiation 1/80 108/8144 0.6581 0.8277 0.8008 HLA-DRB5 1 KEGG hsa04014 Ras signaling pathway 2/80 232/8144 0.67 0.8277 0.8008 HGF/FASLG 2 KEGG hsa04668 TNF signaling pathway 1/80 112/8144 0.6715 0.8277 0.8008 SOCS3 1 KEGG hsa05145 Toxoplasmosis 1/80 112/8144 0.6715 0.8277 0.8008 HLA-DRB5 1 KEGG hsa04724 Glutamatergic synapse 1/80 114/8144 0.678 0.8277 0.8008 GLUL 1 KEGG hsa04151 PI3K-Akt signaling pathway 3/80 354/8144 0.6824 0.8277 0.8008 HGF/PRKAA1/FASLG 3 KEGG hsa04020 Calcium signaling pathway 2/80 240/8144 0.6882 0.8277 0.8008 HGF/GNA15 2 KEGG hsa04722 Neurotrophin signaling pathway 1/80 119/8144 0.6938 0.8277 0.8008 FASLG 1 KEGG hsa04935 Growth hormone synthesis, secretion and action 1/80 119/8144 0.6938 0.8277 0.8008 SOCS3 1 KEGG hsa05132 Salmonella infection 2/80 249/8144 0.7077 0.8386 0.8113 RILP/GSDMD 2 KEGG hsa00230 Purine metabolism 1/80 128/8144 0.7202 0.8394 0.8121 PAPSS1 1 KEGG hsa04380 Osteoclast differentiation 1/80 128/8144 0.7202 0.8394 0.8121 SOCS3 1 KEGG hsa04926 Relaxin signaling pathway 1/80 129/8144 0.723 0.8394 0.8121 GNA15 1 KEGG hsa05322 Systemic lupus erythematosus 1/80 136/8144 0.7418 0.8459 0.8184 HLA-DRB5 1 KEGG hsa04915 Estrogen signaling pathway 1/80 138/8144 0.7469 0.8459 0.8184 FKBP5 1 KEGG hsa04371 Apelin signaling pathway 1/80 139/8144 0.7494 0.8459 0.8184 PRKAA1 1 KEGG hsa05020 Prion disease 2/80 273/8144 0.7548 0.8459 0.8184 UQCRFS1/SDHA 2 KEGG hsa05017 Spinocerebellar ataxia 1/80 143/8144 0.7593 0.8459 0.8184 ATXN3 1 KEGG hsa03040 Spliceosome 1/80 147/8144 0.7688 0.8459 0.8184 SF3B1 1 KEGG hsa04072 Phospholipase D signaling pathway 1/80 148/8144 0.7711 0.8459 0.8184 DGKE 1 KEGG hsa04514 Cell adhesion molecules 1/80 149/8144 0.7734 0.8459 0.8184 HLA-DRB5 1 KEGG hsa05226 Gastric cancer 1/80 149/8144 0.7734 0.8459 0.8184 HGF 1 KEGG hsa01240 Biosynthesis of cofactors 1/80 153/8144 0.7823 0.8459 0.8184 ALPL 1 KEGG hsa04921 Oxytocin signaling pathway 1/80 154/8144 0.7845 0.8459 0.8184 PRKAA1 1 KEGG hsa04010 MAPK signaling pathway 2/80 294/8144 0.7905 0.8459 0.8184 HGF/FASLG 2 KEGG hsa04060 Cytokine-cytokine receptor interaction 2/80 295/8144 0.7921 0.8459 0.8184 IL17RA/FASLG 2 KEGG hsa04530 Tight junction 1/80 169/8144 0.8147 0.8647 0.8365 PRKAA1 1 KEGG hsa05152 Tuberculosis 1/80 180/8144 0.8342 0.88 0.8513 HLA-DRB5 1 KEGG hsa05034 Alcoholism 1/80 187/8144 0.8455 0.8865 0.8576 HDAC9 1 KEGG hsa05202 Transcriptional misregulation in cancer 1/80 193/8144 0.8546 0.8906 0.8616 LYL1 1 KEGG hsa05130 Pathogenic Escherichia coli infection 1/80 197/8144 0.8604 0.8913 0.8623 FASLG 1 KEGG hsa04510 Focal adhesion 1/80 201/8144 0.8659 0.8917 0.8626 HGF 1 KEGG hsa04015 Rap1 signaling pathway 1/80 210/8144 0.8776 0.8983 0.8691 HGF 1 KEGG hsa05166 Human T-cell leukemia virus 1 infection 1/80 222/8144 0.8916 0.9053 0.8759 HLA-DRB5 1 KEGG hsa05163 Human cytomegalovirus infection 1/80 225/8144 0.8949 0.9053 0.8759 FASLG 1 KEGG hsa04740 Olfactory transduction 2/80 440/8144 0.9354 0.9409 0.9102 OR6N2/OR4C13 2 KEGG hsa04080 Neuroactive ligand-receptor interaction 1/80 362/8144 0.9742 0.9742 0.9424 MTNR1B 1