ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04010	MAPK signaling pathway	169/3122	294/8144	1.025e-11	2.925e-09	1.945e-09	TP53/MAPK8IP2/MAPK7/DUSP7/CSF1/MAP3K11/PTPN5/NTRK1/ARRB1/PGF/PRKACA/TAOK2/CACNA2D4/MAPKAPK2/MAP2K7/EFNA1/MAP4K2/ERBB2/MAP2K3/FLT3LG/VEGFB/FGF9/CACNA1S/DUSP3/CACNA1I/NFATC1/NGF/RELA/EGFR/CACNA1H/RELB/IKBKB/EFNA3/MAP3K12/ANGPT2/DUSP1/MYC/MAPK8IP3/RPS6KA4/NTF4/MAPK8IP1/MAPKAPK3/NR4A1/SOS2/MAP2K2/PRKACB/EPHA2/CACNA1A/ATF4/MAP3K6/MAP2K1/JMJD7-PLA2G4B/CACNA2D2/FGFR4/MAPK11/VEGFA/GNG12/CDC42/AKT1/FLT4/INSR/RPS6KA2/CACNG6/CACNB3/GADD45A/CRKL/TRADD/PDGFRA/MAP3K1/TAOK1/AKT2/MAPT/BDNF/HSPA1B/CACNB1/DAXX/CACNA1D/FLT1/TRAF2/CACNA1B/PDGFB/RASGRP1/TGFBR2/CACNB4/CACNA1C/TAOK3/MRAS/HSPA1L/HSPB1/TGFB1/VEGFC/HSPA6/NTF3/ERBB4/FLNC/EFNA2/CACNG4/MAPK12/MAP3K5/RASGRF2/MAP2K5/IL1A/CACNB2/FGFR3/RRAS/FGF21/MAP4K1/PAK2/CACNA1E/FGFR1/MKNK2/PLA2G4F/PLA2G4D/TRAF6/FLNB/AKT3/DUSP4/ANGPT1/IGF2/FGF8/CACNA2D1/PPP3CA/PRKCA/IL1B/PDGFA/ERBB3/FLT3/NTRK2/NLK/CACNA1G/RPS6KA3/CACNA2D3/FGF17/CRK/RAC1/RASGRP4/PDGFC/PDGFRB/IGF1/ELK4/PLA2G4E/PLA2G4B/PRKCB/RAC3/FGF22/NF1/KITLG/FGF6/RAP1B/FGF18/CACNG3/IGF1R/ELK1/MAP2K4/HSPA8/MAP3K14/CSF1R/HSPA1A/NRAS/STK4/ECSIT/EGF/FAS/FOS/RAF1/CACNA1F/MAPKAPK5/NGFR/ARAF	169
KEGG	hsa04360	Axon guidance	114/3122	182/8144	1.751e-11	2.925e-09	1.945e-09	SLIT1/PARD6A/RHOD/BMPR2/CAMK2A/EFNA1/PAK6/RGMA/LIMK1/NCK1/PIK3R3/SEMA4A/UNC5B/NGEF/EPHB4/PLXNA4/EPHA3/SEMA3F/GSK3B/ABL1/PLCG2/EPHA1/NTNG2/EFNA3/CFL1/SLIT3/CDK5/EPHA8/NTN1/RGS3/NTN3/SEMA3B/EPHA2/UNC5A/FZD3/SMO/ROBO2/SEMA4D/PDPK1/LRRC4C/SRC/CDC42/EPHB1/EPHB2/PLXNA1/SEMA6B/ABLIM2/SEMA4C/PLXNB1/DPYSL2/PLXNA3/GDF7/ROCK2/SEMA6D/ROBO1/SEMA5B/CAMK2G/EPHA4/WNT4/PLXNB2/SEMA6C/PLXNA2/DPYSL5/SRGAP3/NFATC2/L1CAM/EFNA2/PRKCZ/WNT5B/PLXNB3/BMPR1B/RRAS/SEMA4G/NCK2/ABLIM1/PAK2/SEMA3C/CXCR4/PAK4/EPHB6/PTCH1/GNAI2/PIK3CA/PIK3R2/TRPC5/PPP3CA/CAMK2B/PRKCA/ENAH/RND1/PAK3/RAC1/LRRC4/GNAI1/NTNG1/RAC3/ABLIM3/SEMA3E/CAMK2D/SEMA3G/BMP7/PARD6G/SSH1/SEMA3A/NRAS/PLXNC1/SEMA7A/PARD6B/PARD3/RAF1/EPHA6/NTN4/PTK2/ARHGEF12	114
KEGG	hsa04921	Oxytocin signaling pathway	94/3122	154/8144	7.328e-09	8.159e-07	5.425e-07	KCNJ9/MAPK7/CDKN1A/PRKACA/CACNA2D4/CAMK2A/PIK3CG/ITPR3/CACNA1S/ADCY4/NFATC1/PLCB3/PRKAG1/MYLK2/EGFR/NPR1/MAP2K2/PRKACB/ADCY5/MAP2K1/JMJD7-PLA2G4B/CACNA2D2/SRC/CAMKK2/KCNJ5/PPP1R12C/CACNG6/CACNB3/PLCB2/CCND1/PPP1CA/OXTR/KCNJ4/MYLK3/CALML4/ROCK2/CACNB1/CAMK2G/CACNA1D/PTGS2/CACNB4/CACNA1C/CAMK1D/ADCY6/NFATC2/ADCY1/EEF2/PRKAG3/PPP1R12B/RYR1/PIK3R6/CACNG4/NOS3/MAP2K5/KCNJ6/CACNB2/KCNJ12/ADCY9/RYR2/ADCY3/PLA2G4F/GNAI2/PLA2G4D/CD38/MYL6B/CACNA2D1/CALML6/PRKAG2/PPP3CA/CAMK2B/PRKCA/CALML5/EEF2K/CALM3/CACNA2D3/MYLK/MYL6/CAMK4/GNAI1/KCNJ3/PLA2G4E/PLA2G4B/PRKCB/ITPR1/CAMK2D/CACNG3/GNAS/NPR2/ELK1/NRAS/FOS/MYLK4/RAF1/CACNA1F	94
KEGG	hsa04020	Calcium signaling pathway	133/3122	240/8144	3.936e-08	3.287e-06	2.185e-06	TPCN1/NTRK1/ITPKB/NOS1/PRKACA/CAMK2A/SLC25A31/MST1R/ERBB2/VEGFB/PHKG1/FGF9/ITPR3/CACNA1S/CACNA1I/ADCY4/PLCB3/TNNC1/NGF/MYLK2/EGFR/CACNA1H/TNNC2/SPHK2/PLCG2/LTB4R2/ATP2A3/STIM1/PLCD3/TBXA2R/ATP2B2/HTR2C/CCKAR/GRIN2D/PRKACB/CACNA1A/PTAFR/SLC8A2/FGFR4/VEGFA/GNAL/FLT4/AVPR1B/ORAI3/PLCB2/NTRK3/ADRA1B/PDGFRA/OXTR/MYLK3/CASQ1/CALML4/ATP2A1/ATP2B4/CAMK2G/CHRM1/CACNA1D/PTK2B/P2RX5/FLT1/PDE1B/ADORA2A/P2RX2/CACNA1B/PDGFB/GNA11/TACR2/GNA15/EDNRB/CACNA1C/GRIN2C/CAMK1D/VEGFC/ADCY1/PTGER1/ERBB4/ORAI1/RYR1/NOS3/CHRM2/NTSR1/FGFR3/MCOLN3/FGF21/GNA14/ADCY9/RYR2/TPCN2/CACNA1E/BDKRB2/CXCR4/ADCY3/EDNRA/FGFR1/CD38/HRC/CHRNA7/HRH2/GRIN2A/FGF8/P2RX1/RET/CALML6/PPP3CA/CAMK2B/PRKCA/CALML5/PDGFA/PTGFR/ERBB3/CALM3/NTRK2/CACNA1G/FGF17/MYLK/PDGFC/PDGFRB/GRIN1/CAMK4/ORAI2/PRKCB/FGF22/ITPR1/CAMK2D/FGF6/FGF18/GNAS/PDE1C/HRH1/HTR5A/EGF/MYLK4/CACNA1F	133
KEGG	hsa04510	Focal adhesion	114/3122	201/8144	6.995e-08	4.64e-06	3.086e-06	THBS3/ACTN4/ITGA2B/ITGB7/PGF/ITGA7/VTN/SHC4/THBS2/PAK6/ERBB2/VEGFB/SHC2/PIK3R3/TLN1/MYLK2/LAMC2/EGFR/GSK3B/LAMA1/BCAR1/MYL2/SHC3/VAV2/COL1A1/ITGA2/RELN/ITGB4/SOS2/VAV1/MAP2K1/PDPK1/ITGA9/SHC1/SRC/ZYX/VEGFA/CDC42/BAD/AKT1/FLT4/VWF/LAMB3/PPP1R12C/COL6A3/TNR/COL4A2/ITGB3/CCND1/CRKL/PARVG/PDGFRA/PPP1CA/ITGA3/AKT2/PIP5K1C/ACTN1/MYLK3/DOCK1/LAMA5/ROCK2/COL4A1/TNXB/FLT1/VASP/PDGFB/CAV3/TNC/VEGFC/PPP1R12B/COL9A3/FLNC/ITGA11/COL6A2/PAK2/PIP5K1A/PAK4/PXN/LAMA3/CCND2/PIK3CA/FLNB/AKT3/PIK3R2/PRKCA/PDGFA/MYLK/ITGA6/PAK3/CRK/RAC1/PDGFC/PDGFRB/IGF1/PRKCB/RAC3/ITGAV/TLN2/RAP1B/PARVA/IGF1R/ELK1/ITGB5/VAV3/COL9A1/MYL7/BCL2/EGF/MYLK4/RAF1/LAMC3/PTK2/MYLPF/CHAD	114
KEGG	hsa04015	Rap1 signaling pathway	118/3122	210/8144	8.335e-08	4.64e-06	3.086e-06	SIPA1L3/CSF1/ITGA2B/PRKD2/PARD6A/PGF/F2RL3/EFNA1/MAP2K3/RAP1GAP/VEGFB/FGF9/ADCY4/PLCB3/MAGI2/PIK3R3/TLN1/NGF/EGFR/BCAR1/EFNA3/RALB/VAV2/ANGPT2/MAP2K2/VAV1/KRIT1/EPHA2/ADCY5/MAP2K1/FGFR4/MAPK11/SRC/VEGFA/CDC42/AKT1/FLT4/INSR/LPAR3/PLCB2/ITGB3/CRKL/PDGFRA/LPAR5/AKT2/RAPGEF6/DRD2/EVL/CALML4/RALGDS/GRIN2B/LPAR2/FLT1/PFN1/ADORA2A/VASP/PFN3/PDGFB/MRAS/ADCY6/VEGFC/ADCY1/ARAP3/EFNA2/PRKCZ/ITGAL/MAPK12/FGFR3/RRAS/FGF21/ADCY9/ADCY3/FGFR1/GNAI2/PIK3CA/AKT3/ANGPT1/PIK3R2/PRKD1/GRIN2A/FGF8/CALML6/PRKCA/CALML5/PDGFA/CALM3/ENAH/SIPA1/FGF17/CRK/LPAR1/RAC1/PDGFC/PDGFRB/GRIN1/IGF1/GNAI1/PRKCB/RAC3/FGF22/KITLG/TLN2/FGF6/RAP1B/FGF18/IGF1R/GNAS/LCP2/VAV3/PARD6G/CSF1R/NRAS/RAPGEF4/EGF/PARD6B/PARD3/RAF1/NGFR	118
KEGG	hsa04151	PI3K-Akt signaling pathway	182/3122	354/8144	2.225e-07	1.062e-05	7.059e-06	THBS3/TP53/CSF1/ITGA2B/SYK/CREB3L1/ITGB7/NTRK1/PPP2R5D/PGF/CDKN1A/PPP2R5A/ITGA7/VTN/PPP2R1B/EFNA1/THBS2/GNG3/ERBB2/JAK3/FLT3LG/VEGFB/PIK3CG/ATF6B/FGF9/MAGI2/PIK3R3/NGF/IFNA14/RELA/LAMC2/STK11/EGFR/GSK3B/TSC2/LAMA1/TSC1/IKBKB/EFNA3/THEM4/ANGPT2/CDK2/COL1A1/IL6R/MYC/ITGA2/RELN/MDM2/NTF4/GH2/ITGB4/NR4A1/SOS2/MAP2K2/MTOR/EPHA2/ATF4/GH1/MAP2K1/PDPK1/ITGA9/FGFR4/VEGFA/GNG12/BAD/AKT1/CSF3R/CDC37/PHLPP2/FLT4/VWF/INSR/LAMB3/PPP2R2C/COL6A3/TNR/COL4A2/LPAR3/G6PC3/ITGB3/CCND1/PDGFRA/PIK3AP1/CRTC2/LPAR5/ITGA3/AKT2/IL2/LAMA5/BDNF/RXRA/RPTOR/GNG5/PKN1/CHRM1/COL4A1/IL4R/TNXB/LPAR2/FLT1/IFNA13/PDGFB/TNC/MLST8/PKN3/VEGFC/NTF3/ERBB4/HSP90AA1/COL9A3/EFNA2/PIK3R6/ITGA11/NOS3/CHRM2/GNB4/HSP90AB1/PPP2R5B/FGFR3/FGF21/OSMR/COL6A2/RPS6KB2/RHEB/CDK4/FGFR1/LAMA3/PPP2R1A/CCND2/CSH1/PIK3CA/GHR/AKT3/ANGPT1/PIK3R2/IGF2/FGF8/PRKCA/PDGFA/ERBB3/FLT3/PPP2R3C/NTRK2/FGF17/ITGA6/YWHAG/LPAR1/RAC1/PDGFC/PDGFRB/IFNAR1/IGF1/GNB3/GNB2/FGF22/ITGAV/KITLG/FGF6/LPAR6/FGF18/GNG4/IGF1R/EIF4E2/ITGB5/COL9A1/PPP2R2A/CSF1R/NRAS/IL4/IL3/CD19/PRLR/BCL2/EGF/RAF1/LAMC3/YWHAE/GNG13/PTK2/SGK1/NGFR/CHAD	182
KEGG	hsa04014	Ras signaling pathway	126/3122	232/8144	4.075e-07	1.701e-05	1.131e-05	CSF1/NTRK1/PGF/PRKACA/SHC4/EFNA1/PLA2G2D/GNG3/PAK6/FLT3LG/VEGFB/SHC2/FGF9/ZAP70/PIK3R3/RAB5C/NGF/RELA/SYNGAP1/RGL2/EGFR/PLA2G5/ABL1/PLCG2/IKBKB/EFNA3/RALB/SHC3/ANGPT2/RASSF1/NTF4/SOS2/MAP2K2/PRKACB/EPHA2/PLA2G6/PLA2G12B/MAP2K1/JMJD7-PLA2G4B/FGFR4/SHC1/VEGFA/GNG12/CDC42/BAD/AKT1/FLT4/INSR/PLA2G2F/PDGFRA/PLA2G2E/RASAL1/AKT2/RASA3/BDNF/CALML4/RALGDS/GRIN2B/GNG5/FLT1/PDGFB/RASGRP1/KSR1/MRAS/VEGFC/NTF3/EFNA2/PLA2G2A/RASGRF2/GNB4/FGFR3/RRAS/FGF21/RIN1/PAK2/PAK4/FGFR1/PLA2G4F/PIK3CA/PLA2G4D/AKT3/ANGPT1/PIK3R2/IGF2/GRIN2A/FGF8/CALML6/PRKCA/CALML5/PDGFA/FLT3/CALM3/NTRK2/FGF17/PAK3/RAC1/RASGRP4/PDGFC/PDGFRB/GRIN1/IGF1/PLA2G4E/PLA2G4B/PRKCB/RAC3/GNB3/GNB2/FGF22/NF1/KITLG/FGF6/RAP1B/FGF18/GNG4/KSR2/IGF1R/RASAL2/ELK1/CSF1R/NRAS/STK4/EGF/RAF1/GNG13/NGFR/PLD1	126
KEGG	hsa04725	Cholinergic synapse	69/3122	113/8144	7.149e-07	2.653e-05	1.764e-05	CREB3L1/CHRNA4/PRKACA/CAMK2A/GNG3/PIK3CG/ITPR3/CACNA1S/ADCY4/KCNQ3/PLCB3/PIK3R3/KCNQ4/PRKACB/CACNA1A/ADCY5/ATF4/KCNQ1/MAP2K1/ACHE/GNG12/AKT1/KCNQ2/PLCB2/AKT2/KCNJ4/GNG5/CHRNA3/CAMK2G/CHRM1/SLC5A7/CACNA1D/CACNA1B/GNA11/CACNA1C/ADCY6/ADCY1/PIK3R6/CHRM4/CHRM2/GNB4/KCNJ6/KCNJ12/CHRNB4/ADCY9/ADCY3/GNAI2/PIK3CA/CHRNA7/AKT3/PIK3R2/CHRNB2/CAMK2B/PRKCA/KCNQ5/CAMK4/GNAI1/KCNJ3/PRKCB/GNB3/GNB2/ITPR1/CAMK2D/GNG4/NRAS/BCL2/FOS/GNG13/CACNA1F	69
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	86/3122	150/8144	1.531e-06	5.113e-05	3.4e-05	CREB3L1/TPM2/PPP2R5D/PRKACA/TNNT2/PPP2R5A/CACNA2D4/PPP2R1B/CAMK2A/SCN4B/PIK3CG/ATF6B/FXYD2/CACNA1S/SCN1B/ADCY4/PLCB3/TNNC1/TPM3/MYL2/ATP2A3/ATP2B2/PRKACB/ADCY5/ATF4/KCNQ1/SLC8A2/CACNA2D2/MAPK11/ATP1B1/AKT1/PPP2R2C/CACNG6/CACNB3/PLCB2/ADRA1B/PPP1CA/AKT2/CALML4/ATP2A1/ATP2B4/CACNB1/CAMK2G/CACNA1D/ATP1A2/CACNB4/CACNA1C/ATP1A1/TPM4/ADCY6/ADCY1/ATP1A3/PIK3R6/CACNG4/MAPK12/MYH7/CACNB2/PPP2R5B/ADCY9/RYR2/ADCY3/PPP2R1A/GNAI2/MYH6/AKT3/SLC9A1/MYL4/ATP1A4/CACNA2D1/KCNE1/CALML6/CAMK2B/PRKCA/CALML5/CALM3/PPP2R3C/CACNA2D3/GNAI1/TPM1/CAMK2D/CACNG3/GNAS/PPP2R2A/RAPGEF4/BCL2/CACNA1F	86
KEGG	hsa05214	Glioma	49/3122	75/8144	1.821e-06	5.528e-05	3.676e-05	TP53/CDKN1A/CAMK2A/SHC4/SHC2/PIK3R3/BAK1/EGFR/PLCG2/SHC3/MDM2/SOS2/MAP2K2/MTOR/MAP2K1/SHC1/AKT1/CCND1/GADD45A/PDGFRA/AKT2/CALML4/CAMK2G/PDGFB/CAMK1D/DDB2/CDK4/PIK3CA/AKT3/E2F1/PIK3R2/CALML6/CAMK2B/PRKCA/CALML5/PDGFA/CALM3/PDGFRB/CAMK4/IGF1/PRKCB/CAMK2D/IGF1R/NRAS/EGF/RAF1/RB1/E2F3/ARAF	49
KEGG	hsa04925	Aldosterone synthesis and secretion	60/3122	98/8144	3.324e-06	8.635e-05	5.742e-05	CYP11A1/PRKD2/CREB3L1/PDE2A/PRKACA/KCNK3/CAMK2A/ATF6B/ITPR3/CACNA1S/CACNA1I/ADCY4/PLCB3/CACNA1H/LDLR/SCARB1/NPR1/LIPE/ATP2B2/MC2R/NR4A1/PRKACB/ADCY5/ATF4/ATP1B1/KCNJ5/PLCB2/CALML4/DAGLA/ATP2B4/CAMK2G/CACNA1D/KCNK9/ATP1A2/GNA11/CACNA1C/CAMK1D/ATP1A1/ADCY6/CYP21A2/ADCY1/ORAI1/ATP1A3/ADCY9/ADCY3/PRKD1/ATP1A4/CALML6/PRKCE/CAMK2B/PRKCA/CALML5/CALM3/CACNA1G/CAMK4/PRKCB/ITPR1/CAMK2D/GNAS/CACNA1F	60
KEGG	hsa05414	Dilated cardiomyopathy	59/3122	96/8144	3.361e-06	8.635e-05	5.742e-05	ITGA2B/ITGB7/TPM2/PRKACA/LMNA/TNNT2/CACNA2D4/ITGA7/CACNA1S/ADCY4/TNNC1/TPM3/LAMA1/MYL2/ATP2A3/ITGA2/ITGB4/PRKACB/ADCY5/SLC8A2/ITGA9/DES/CACNA2D2/CACNG6/CACNB3/ITGB3/MYBPC3/ITGA3/SGCD/ATP2A1/CACNB1/CACNA1D/DAG1/CACNB4/CACNA1C/TPM4/ADCY6/TGFB1/ADCY1/CACNG4/ITGA11/MYH7/CACNB2/ADCY9/RYR2/ADCY3/MYH6/CACNA2D1/CACNA2D3/ITGA6/SGCA/IGF1/TPM1/ITGAV/CACNG3/GNAS/ITGB5/SGCG/CACNA1F	59
KEGG	hsa04270	Vascular smooth muscle contraction	77/3122	134/8144	4.765e-06	0.0001137	7.559e-05	PRKACA/PLA2G2D/RAMP2/ITPR3/CACNA1S/ADCY4/PLCB3/MRVI1/MYLK2/PTGIR/PLA2G5/MYH9/NPR1/MAP2K2/PRKACB/ADCY5/PLA2G6/PLA2G12B/NPPB/MAP2K1/JMJD7-PLA2G4B/KCNMB1/AVPR1B/PLA2G2F/PPP1R12C/ACTA2/PRKCH/PLCB2/ADRA1B/PLA2G2E/PPP1CA/MYLK3/CALML4/ROCK2/CACNA1D/CALCRL/ADORA2A/GNA11/CACNA1C/ADCY6/ADCY1/PPP1R12B/RAMP1/PLA2G2A/ADM2/ADCY9/ADCY3/EDNRA/PLA2G4F/MYH14/ARHGEF1/PLA2G4D/MYL6B/MYH10/AVP/CALML6/PRKCE/PRKCA/CALML5/CALM3/MYLK/EDN2/MYL6/PLA2G4E/PLA2G4B/PRKCB/ITPR1/GNAS/NPR2/PPP1R14A/MYLK4/RAF1/CACNA1F/CALCB/KCNMA1/ARHGEF12/ARAF	77
KEGG	hsa04912	GnRH signaling pathway	57/3122	93/8144	5.55e-06	0.0001236	8.218e-05	MAPK7/PRKACA/CAMK2A/MAP2K7/MAP2K3/HBEGF/ITPR3/CACNA1S/ADCY4/PLCB3/MMP2/EGFR/SOS2/MAP2K2/PRKACB/ADCY5/ATF4/MAP2K1/JMJD7-PLA2G4B/MAPK11/SRC/CDC42/PLCB2/GNRH2/MAP3K1/MMP14/CALML4/CAMK2G/CACNA1D/PTK2B/GNA11/CACNA1C/ADCY6/ADCY1/MAPK12/ADCY9/ADCY3/PLA2G4F/PLA2G4D/CALML6/CAMK2B/PRKCA/CALML5/CALM3/PLA2G4E/PLA2G4B/PRKCB/ITPR1/CAMK2D/GNAS/LHB/ELK1/MAP2K4/NRAS/RAF1/CACNA1F/PLD1	57
KEGG	hsa04310	Wnt signaling pathway	92/3122	167/8144	6.81e-06	0.0001422	9.453e-05	TP53/CSNK2B/TCF7/DVL3/SMAD3/PRKACA/SOST/WNT3/CAMK2A/WNT2B/SFRP5/WNT11/NFATC1/PLCB3/WNT16/GSK3B/TLE3/LRP5/PPARD/WIF1/NOTUM/AXIN1/MYC/TLE2/DAAM2/PRKACB/FZD3/WNT8A/FZD2/DVL1/FZD4/FZD9/CUL1/PLCB2/CCND1/WNT7A/RSPO1/TCF7L1/TBL1X/TLE1/NKD2/CTNNBIP1/ROCK2/CTBP1/PSEN1/SFRP1/NKD1/CAMK2G/WNT4/PRICKLE1/PRICKLE2/LRP6/RSPO4/NFATC2/WNT3A/WNT7B/CSNK1A1/CTNND2/WNT6/WNT5B/AXIN2/CTBP2/CCND2/GPC4/ZNRF3/ROR2/CREBBP/PPP3CA/LGR6/PRICKLE3/CAMK2B/PRKCA/TCF7L2/NLK/WNT9A/RAC1/FZD5/CSNK1E/SERPINF1/APC/PRKCB/RAC3/RUVBL1/DKK2/CAMK2D/TLE6/TBL1XR1/VANGL2/VANGL1/MMP7/FBXW11/RSPO2	92
KEGG	hsa05165	Human papillomavirus infection	165/3122	331/8144	9.048e-06	0.0001661	0.0001105	THBS3/TP53/TCF7/DVL3/RFNG/IRF9/ITGA2B/CREB3L1/ITGB7/PARD6A/PPP2R5D/CDKN1A/PRKACA/PPP2R5A/CHD4/ITGA7/VTN/PPP2R1B/WNT3/TICAM1/WNT2B/NOTCH3/THBS2/NOTCH1/WNT11/ATP6V1F/ATP6V1G2/LLGL2/WNT16/PIK3R3/TYK2/IFNA14/RELA/BAK1/LAMC2/EGFR/GSK3B/TSC2/LAMA1/SCRIB/FOXO1/TSC1/IKBKB/LFNG/AXIN1/CDK2/COL1A1/ITGA2/ATP6V1A/RELN/MDM2/ATP6V0E1/ITGB4/SOS2/MAP2K2/PRKACB/MTOR/FZD3/MAP2K1/ITGA9/HLA-G/WNT8A/FZD2/VEGFA/CDC42/DVL1/HEYL/BAD/AKT1/FZD4/FZD9/VWF/LAMB3/PPP2R2C/COL6A3/TNR/COL4A2/ATP6V0C/ITGB3/CCND1/WNT7A/TRADD/TCF7L1/ATP6V0A1/ATP6V1E1/IRF3/ITGA3/AKT2/LAMA5/CASP8/PSEN1/COL4A1/STAT2/TLR3/TNXB/OASL/WNT4/PTGS2/IFNA13/TNC/ATP6V0E2/TCIRG1/HLA-F/WNT3A/WNT7B/COL9A3/CSNK1A1/ATP6V0D1/PRKCZ/ITGA11/WNT6/WNT5B/HES2/AXIN2/PPP2R5B/ISG15/ATM/COL6A2/RPS6KB2/RHEB/CDK4/PXN/LAMA3/PPP2R1A/CCND2/PIK3CA/TERT/AKT3/E2F1/CREBBP/PIK3R2/MX1/PPP2R3C/RBPJ/NOTCH4/TCF7L2/WNT9A/ITGA6/UBR4/PDGFRB/FZD5/IFNAR1/APC/HES1/ITGAV/GNAS/RBPJL/RBL1/TBPL1/ITGB5/PARD6G/COL9A1/PPP2R2A/NRAS/CCNA2/EGF/PARD6B/FAS/PARD3/RAF1/LAMC3/RB1/PTK2/CHAD/MX2	165
KEGG	hsa04911	Insulin secretion	53/3122	86/8144	9.364e-06	0.0001661	0.0001105	CREB3L1/PRKACA/CAMK2A/ATF6B/FXYD2/ITPR3/RIMS2/CACNA1S/ADCY4/PLCB3/PCLO/STX1A/GCK/CCKAR/ABCC8/PRKACB/ADCY5/ATF4/KCNMB1/ATP1B1/PLCB2/FFAR1/SLC2A1/CAMK2G/CACNA1D/SLC2A2/ADCYAP1R1/KCNN3/ATP1A2/GNA11/CACNA1C/ATP1A1/ADCY6/ADCY1/ATP1A3/KCNJ11/KCNN1/ADCY9/RYR2/GIP/ADCY3/KCNN4/ATP1A4/CAMK2B/PRKCA/SNAP25/PRKCB/CAMK2D/CCK/GNAS/RAPGEF4/CACNA1F/KCNMA1	53
KEGG	hsa05225	Hepatocellular carcinoma	92/3122	168/8144	9.452e-06	0.0001661	0.0001105	TP53/TCF7/DVL3/SMAD3/CDKN1A/SMARCD3/WNT3/SHC4/WNT2B/GSTM4/SMARCB1/WNT11/SHC2/TXNRD1/WNT16/PIK3R3/BAK1/GSTT2/EGFR/GSK3B/PLCG2/LRP5/SHC3/AXIN1/MYC/SMARCA4/TXNRD2/BRD7/SOS2/MAP2K2/MTOR/FZD3/MAP2K1/WNT8A/SHC1/FZD2/DVL1/BAD/AKT1/GSTT2B/FZD4/FZD9/DPF3/CCND1/GADD45A/WNT7A/TCF7L1/AKT2/DPF1/WNT4/TGFBR2/ARID2/GSTM3/LRP6/TGFB1/DDB2/WNT3A/WNT7B/CSNK1A1/KEAP1/WNT6/WNT5B/AXIN2/RPS6KB2/CDK4/PIK3CA/TERT/AKT3/E2F1/PIK3R2/IGF2/SMARCA2/GSTO1/PRKCA/SMARCD1/TCF7L2/WNT9A/FZD5/APC/PRKCB/HMOX1/GSTA5/IGF1R/ELK1/ARID1B/NRAS/ARID1A/RAF1/NQO1/RB1/E2F3/ARAF	92
KEGG	hsa05224	Breast cancer	82/3122	147/8144	1.136e-05	0.0001897	0.0001261	TP53/TCF7/DVL3/CDKN1A/WNT3/SHC4/WNT2B/BRCA2/NOTCH3/NOTCH1/WNT11/ERBB2/SHC2/FGF9/WNT16/PIK3R3/BAK1/EGFR/GSK3B/LRP5/SHC3/AXIN1/MYC/SOS2/MAP2K2/MTOR/FZD3/MAP2K1/WNT8A/SHC1/FZD2/DVL1/HEYL/AKT1/FZD4/FZD9/PGR/FLT4/CCND1/GADD45A/WNT7A/TCF7L1/AKT2/NCOA1/DLL4/WNT4/LRP6/DDB2/WNT3A/WNT7B/CSNK1A1/WNT6/WNT5B/AXIN2/FGF21/RPS6KB2/CDK4/FGFR1/PIK3CA/AKT3/E2F1/PIK3R2/FGF8/NOTCH4/TCF7L2/WNT9A/FGF17/FZD5/IGF1/APC/HES1/FGF22/FGF6/FGF18/IGF1R/NRAS/EGF/FOS/RAF1/RB1/E2F3/ARAF	82
KEGG	hsa04611	Platelet activation	71/3122	124/8144	1.312e-05	0.0002087	0.0001388	ITGA2B/SYK/PTGS1/PRKACA/F2RL3/FERMT3/PIK3CG/ITPR3/ADCY4/PLCB3/PIK3R3/TLN1/MYLK2/PTGIR/PLCG2/P2RY12/COL1A1/STIM1/ITGA2/TBXA2R/PRKACB/ADCY5/JMJD7-PLA2G4B/MAPK11/SRC/GP1BB/AKT1/VWF/PLCB2/ITGB3/PPP1CA/AKT2/MYLK3/ROCK2/VASP/RASGRP1/GP1BA/TBXAS1/ADCY6/ADCY1/ORAI1/F2/PRKCZ/PIK3R6/MAPK12/NOS3/ADCY9/ADCY3/PLA2G4F/GNAI2/PIK3CA/ARHGEF1/PLA2G4D/AKT3/LYN/PIK3R2/P2RX1/MYLK/GNAI1/BTK/COL3A1/PLA2G4E/PLA2G4B/GP9/ITPR1/TLN2/RAP1B/GNAS/LCP2/MYLK4/ARHGEF12	71
KEGG	hsa04910	Insulin signaling pathway	77/3122	137/8144	1.448e-05	0.0002115	0.0001407	HK2/PRKACA/PDE3B/INPPL1/SHC4/PKLR/SHC2/PHKG1/PIK3R3/PRKAG1/GSK3B/TSC2/FBP1/FOXO1/FLOT1/TSC1/IKBKB/SREBF1/SHC3/PTPRF/GCK/LIPE/PRKAR1B/SOS2/MAP2K2/PRKACB/MTOR/HK3/MAP2K1/PDPK1/SHC1/BAD/AKT1/SH2B2/INSR/HKDC1/G6PC3/CRKL/HK1/PPP1CA/AKT2/CALML4/RPTOR/TRIP10/INPP5A/PRKAG3/PYGB/PRKCZ/SLC2A4/RPS6KB2/RHEB/FASN/MKNK2/SOCS4/PIK3CA/PYGM/AKT3/PIK3R2/CALML6/PRKAG2/CALML5/CALM3/PPP1R3E/PTPN1/SORBS1/CRK/FBP2/CBL/SOCS2/EIF4E2/ACACB/ELK1/FLOT2/EXOC7/NRAS/RAF1/ARAF	77
KEGG	hsa05217	Basal cell carcinoma	41/3122	63/8144	1.457e-05	0.0002115	0.0001407	TP53/TCF7/DVL3/CDKN1A/WNT3/WNT2B/WNT11/HHIP/WNT16/KIF7/BAK1/GSK3B/AXIN1/FZD3/SMO/WNT8A/FZD2/DVL1/FZD4/FZD9/GADD45A/WNT7A/TCF7L1/WNT4/SUFU/GLI2/DDB2/WNT3A/WNT7B/WNT6/WNT5B/AXIN2/PTCH1/BMP4/GLI3/BMP2/TCF7L2/WNT9A/FZD5/APC/PTCH2	41
KEGG	hsa04012	ErbB signaling pathway	52/3122	85/8144	1.531e-05	0.0002131	0.0001417	CDKN1A/NRG2/CAMK2A/SHC4/MAP2K7/PAK6/ERBB2/HBEGF/SHC2/NCK1/PIK3R3/EGFR/GSK3B/ABL1/PLCG2/SHC3/MYC/SOS2/MAP2K2/MTOR/MAP2K1/SHC1/SRC/BAD/AKT1/CRKL/AKT2/CAMK2G/ERBB4/NCK2/PAK2/RPS6KB2/PAK4/PIK3CA/AKT3/PIK3R2/CAMK2B/PRKCA/ERBB3/PAK3/CRK/BTC/PRKCB/CBL/CAMK2D/ELK1/MAP2K4/NRAS/EGF/RAF1/PTK2/ARAF	52
KEGG	hsa04072	Phospholipase D signaling pathway	82/3122	148/8144	1.6e-05	0.0002138	0.0001422	SYK/SHC4/SHC2/PIK3CG/CYTH2/ADCY4/PLCB3/PIK3R3/EGFR/TSC2/SPHK2/PLCG2/DNM2/TSC1/RALB/SHC3/GRM4/DGKD/SOS2/MAP2K2/MTOR/ADCY5/MAP2K1/JMJD7-PLA2G4B/AGPAT2/SHC1/GRM6/AKT1/AVPR1B/INSR/LPAR3/DNM1/PLCB2/PDGFRA/AGPAT4/LPAR5/AKT2/PIP5K1C/RALGDS/GRM2/PTK2B/LPAR2/AVPR2/PDGFB/MRAS/ADCY6/ADCY1/F2/PIK3R6/DGKB/DNM3/RRAS/ADCY9/DGKZ/PIP5K1A/RHEB/ADCY3/PLA2G4F/PIK3CA/PLA2G4D/AKT3/PIK3R2/AVP/PRKCA/PDGFA/PTGFR/CYTH3/LPAR1/PDGFC/PDGFRB/PLA2G4E/PLA2G4B/KITLG/LPAR6/GNAS/AGPAT3/NRAS/ARF1/RAPGEF4/EGF/RAF1/PLD1	82
KEGG	hsa05226	Gastric cancer	82/3122	149/8144	2.236e-05	0.0002873	0.000191	TP53/TCF7/DVL3/SMAD3/CDKN1A/JUP/WNT3/SHC4/RXRB/WNT2B/WNT11/ERBB2/SHC2/FGF9/WNT16/PIK3R3/BAK1/EGFR/GSK3B/LRP5/SHC3/AXIN1/CDK2/MYC/SOS2/MAP2K2/MTOR/FZD3/MAP2K1/WNT8A/SHC1/FZD2/DVL1/AKT1/FZD4/FZD9/CCND1/GADD45A/WNT7A/TCF7L1/AKT2/RXRA/WNT4/TGFBR2/LRP6/CTNNA2/TGFB1/DDB2/WNT3A/WNT7B/CSNK1A1/WNT6/WNT5B/AXIN2/FGF21/RPS6KB2/PIK3CA/TERT/AKT3/E2F1/PIK3R2/FGF8/TCF7L2/WNT9A/FGF17/FZD5/APC/FGF22/FGF6/FGF18/MLH1/CTNNA1/RXRG/NRAS/MUC2/BCL2/EGF/ABCB1/RAF1/RB1/E2F3/ARAF	82
KEGG	hsa05410	Hypertrophic cardiomyopathy	54/3122	90/8144	2.339e-05	0.0002893	0.0001924	ITGA2B/ITGB7/TPM2/LMNA/TNNT2/CACNA2D4/ITGA7/CACNA1S/TNNC1/PRKAG1/TPM3/LAMA1/MYL2/ATP2A3/ITGA2/ITGB4/SLC8A2/ITGA9/DES/CACNA2D2/CACNG6/CACNB3/ITGB3/MYBPC3/ITGA3/SGCD/ATP2A1/CACNB1/CACNA1D/DAG1/CACNB4/CACNA1C/TPM4/TGFB1/PRKAG3/CACNG4/ITGA11/MYH7/CACNB2/RYR2/MYH6/CACNA2D1/PRKAG2/CACNA2D3/ACE/ITGA6/SGCA/IGF1/TPM1/ITGAV/CACNG3/ITGB5/SGCG/CACNA1F	54
KEGG	hsa05205	Proteoglycans in cancer	107/3122	205/8144	3.111e-05	0.0003711	0.0002468	TP53/CDKN1A/PRKACA/VTN/WNT3/CAMK2A/WNT2B/WNT11/ERBB2/HBEGF/ITPR3/TFAP4/WNT16/PIK3R3/TWIST2/MMP2/EGFR/PLCG2/VAV2/COL1A1/MYC/ITGA2/MDM2/SOS2/MAP2K2/VAV1/PRKACB/MTOR/ANK1/FZD3/SMO/MAP2K1/PDPK1/MAPK11/WNT8A/FZD2/SRC/VEGFA/CDC42/AKT1/FZD4/FZD9/PPP1R12C/ITGB3/CCND1/WNT7A/CTTN/PPP1CA/AKT2/GPC1/ROCK2/CAMK2G/WNT4/CAV3/MRAS/PLAUR/TGFB1/ERBB4/PPP1R12B/WNT3A/WNT7B/FLNC/WNT6/MAPK12/WNT5B/IHH/RRAS/HSPB2/RPS6KB2/PXN/FGFR1/PTCH1/PIK3CA/ARHGEF1/CD44/FLNB/AKT3/SLC9A1/PIK3R2/IGF2/CAMK2B/PRKCA/ERBB3/WNT9A/RAC1/HSPG2/FZD5/IGF1/PRKCB/SDC4/ITGAV/CBL/ITPR1/CAMK2D/IGF1R/DDX5/ELK1/ITGB5/VAV3/GPC3/FRS2/NRAS/FAS/RAF1/PTK2/ARHGEF12/ARAF	107
KEGG	hsa04370	VEGF signaling pathway	38/3122	59/8144	4.227e-05	0.0004869	0.0003238	MAPKAPK2/SH2D2A/SHC2/PIK3R3/SPHK2/PLCG2/MAPKAPK3/MAP2K2/MAP2K1/JMJD7-PLA2G4B/MAPK11/SRC/VEGFA/CDC42/BAD/AKT1/AKT2/PTGS2/HSPB1/NFATC2/MAPK12/NOS3/PXN/PLA2G4F/PIK3CA/PLA2G4D/AKT3/PIK3R2/PPP3CA/PRKCA/RAC1/PLA2G4E/PLA2G4B/PRKCB/RAC3/NRAS/RAF1/PTK2	38
KEGG	hsa04722	Neurotrophin signaling pathway	67/3122	119/8144	4.758e-05	0.0005126	0.0003409	TP53/MAPK7/NTRK1/MAPKAPK2/CAMK2A/SHC4/MAP2K7/SHC2/ARHGDIG/PIK3R3/NGF/RELA/GSK3B/ABL1/PLCG2/IKBKB/SHC3/NTF4/SOS2/MAP2K2/ATF4/MAP2K1/PDPK1/MAPK11/SHC1/CDC42/BAD/AKT1/SH2B2/RPS6KA2/NTRK3/CRKL/MAP3K1/AKT2/BDNF/CALML4/TP73/PSEN1/CAMK2G/MATK/NTF3/MAPK12/MAP3K5/MAP2K5/PIK3CA/TRAF6/AKT3/PIK3R2/CALML6/CAMK2B/CALML5/CALM3/NTRK2/RPS6KA3/CRK/RAC1/CAMK4/NFKBIB/CAMK2D/RAP1B/FRS2/NRAS/BCL2/RAF1/YWHAE/NGFR/NFKBIE	67
KEGG	hsa04935	Growth hormone synthesis, secretion and action	67/3122	119/8144	4.758e-05	0.0005126	0.0003409	CREB3L1/PRKACA/SHC4/MAP2K3/SHC2/ATF6B/ITPR3/CACNA1S/ADCY4/IGFALS/PLCB3/PIK3R3/GSK3B/PLCG2/BCAR1/SHC3/GH2/SOS2/MAP2K2/PRKACB/MTOR/ADCY5/ATF4/GH1/MAP2K1/SSTR5/MAPK11/SHC1/AKT1/PLCB2/POU1F1/CRKL/MAP3K1/AKT2/ADCY10/CACNA1D/GNA11/CACNA1C/ADCY6/ADCY1/GHRH/MAPK12/ADCY9/ADCY3/CSH1/GNAI2/PIK3CA/GHR/SSTR3/AKT3/CREBBP/PIK3R2/PRKCA/GHRHR/CRK/IGF1/GNAI1/PRKCB/ITPR1/SOCS2/GNAS/MAP2K4/NRAS/FOS/RAF1/CACNA1F/PTK2	67
KEGG	hsa04810	Regulation of actin cytoskeleton	112/3122	218/8144	4.997e-05	0.0005215	0.0003468	ACTN4/ITGA2B/CYFIP2/ITGB7/SCIN/INSRR/ITGA7/ARHGEF7/ARPC1B/PAK6/LIMK1/FGF9/PIK3R3/MYLK2/EGFR/BCAR1/MYL2/ARHGEF4/VAV2/CFL1/MYH9/ITGA2/ITGAD/ITGB4/SOS2/MAP2K2/VAV1/IQGAP3/MAP2K1/ITGA9/FGFR4/SRC/GNG12/CDC42/PPP1R12C/ITGB3/CRKL/PDGFRA/PPP1CA/LPAR5/ITGA3/PIP5K1C/ACTN1/MYLK3/DOCK1/ROCK2/PIP4K2B/CYFIP1/CHRM1/LPAR2/ACTR3B/PFN1/PFN3/PDGFB/MRAS/PPP1R12B/F2/GSN/ITGAL/CHRM4/ITGA11/CHRM2/FGFR3/RRAS/FGF21/GIT1/PAK2/BDKRB2/CXCR4/PIP5K1A/PAK4/PXN/FGFR1/MYH14/PIK3CA/ARHGEF1/SLC9A1/PIK3R2/FGF8/MYH10/PDGFA/ENAH/ABI2/FGF17/MYLK/ITGA6/PAK3/CRK/LPAR1/RAC1/PDGFC/PDGFRB/APC/RAC3/BAIAP2/FGF22/ITGAV/FGF6/FGF18/ITGB5/VAV3/SSH1/MYL7/NRAS/EGF/ARPC5L/MYLK4/RAF1/PTK2/MYLPF/ARHGEF12/ARAF	112
KEGG	hsa04024	cAMP signaling pathway	113/3122	221/8144	6.029e-05	0.0006102	0.0004058	GIPR/CREB3L1/PDE4C/PRKACA/PDE3B/ACOX3/CAMK2A/VIPR2/CNGB1/FFAR2/PPP1R1B/FXYD2/HCN4/HHIP/CACNA1S/ADCY4/NFATC1/PIK3R3/RELA/VAV2/ATP2A3/CRHR1/NPR1/CNGA3/LIPE/ATP2B2/MC2R/MAP2K2/VAV1/GRIN2D/PRKACB/ADCY5/ADORA1/MAP2K1/SSTR5/GABBR1/ATP1B1/BAD/AKT1/CRHR2/PPP1CA/OXTR/AKT2/ADCY10/DRD2/BDNF/CALML4/ATP2A1/ROCK2/ATP2B4/AMH/GRIN2B/GABBR2/CAMK2G/CHRM1/CACNA1D/ADCYAP1R1/GPHA2/ADORA2A/ATP1A2/CACNA1C/PDE3A/GRIN2C/ATP1A1/ADCY6/ADCY1/ORAI1/ARAP3/SUCNR1/ATP1A3/CHRM2/RRAS/PDE4A/ADCY9/RYR2/GIP/ADCY3/EDNRA/PTCH1/GNAI2/PIK3CA/GLI3/AKT3/SLC9A1/CREBBP/PIK3R2/ATP1A4/GRIN2A/CALML6/CAMK2B/CALML5/CALM3/CNGA4/RAC1/EDN2/GRIN1/CAMK4/GNAI1/ACOX1/RAC3/CAMK2D/RAP1B/GNAS/PDE4B/LHB/NPY/VAV3/PDE10A/RAPGEF4/FOS/RAF1/CACNA1F/PLD1	113
KEGG	hsa04390	Hippo signaling pathway	84/3122	157/8144	7.017e-05	0.0006893	0.0004584	TCF7/DVL3/SMAD3/PARD6A/CSNK1D/BMPR2/BMP8A/PPP2R1B/WNT3/WNT2B/GDF5/WNT11/SERPINE1/LATS1/LLGL2/WNT16/AMOT/GSK3B/SCRIB/TEAD3/BIRC5/AXIN1/MYC/BMP8B/RASSF1/FZD3/SAV1/TEAD4/WNT8A/FZD2/DVL1/FZD4/FZD9/WWC1/PPP2R2C/BBC3/CCND1/WNT7A/TCF7L1/PPP1CA/WWTR1/NKD2/GDF7/TP73/AMH/NKD1/FRMD1/WNT4/CRB2/TGFBR2/CTNNA2/GLI2/TGFB1/WNT3A/WNT7B/SMAD7/PRKCZ/WNT6/WNT5B/LATS2/AXIN2/BMPR1B/SMAD1/PPP2R1A/CCND2/BMP4/DLG5/BMP2/TCF7L2/WNT9A/YWHAG/FZD5/CSNK1E/APC/LIMD1/CTNNA1/BMP7/PARD6G/PPP2R2A/PARD6B/PARD3/YWHAE/DLG4/FBXW11	84
KEGG	hsa04929	GnRH secretion	40/3122	64/8144	7.332e-05	0.0006997	0.0004653	KCNJ9/ARRB1/ITPR3/CACNA1S/CACNA1I/PLCB3/PIK3R3/CACNA1H/MAP2K2/MAP2K1/GABBR1/AKT1/KCNJ5/PLCB2/GNRH2/AKT2/GABBR2/CACNA1D/KCNN3/GNA11/CACNA1C/KCNJ11/KCNJ6/KCNN1/PIK3CA/AKT3/KCNN4/PIK3R2/KISS1/TRPC5/PRKCA/CACNA1G/KCNJ3/PRKCB/ITPR1/HCN3/LHB/NRAS/RAF1/CACNA1F	40
KEGG	hsa04713	Circadian entrainment	56/3122	97/8144	7.697e-05	0.0007141	0.0004749	KCNJ9/NOS1/PRKACA/CAMK2A/GNG3/ITPR3/CACNA1I/ADCY4/PLCB3/CACNA1H/PER2/PER1/GRIN2D/PRKACB/ADCY5/GNG12/KCNJ5/PLCB2/ADCY10/CALML4/GRIN2B/GNG5/CAMK2G/CACNA1D/ADCYAP1R1/CACNA1C/GRIN2C/ADCY6/ADCY1/RYR1/GNB4/KCNJ6/ADCY9/RYR2/ADCY3/GNAI2/MTNR1B/GRIN2A/CALML6/CAMK2B/PRKCA/CALML5/CALM3/CACNA1G/GRIN1/GNAI1/KCNJ3/PRKCB/GNB3/GNB2/ITPR1/CAMK2D/GNG4/GNAS/FOS/GNG13	56
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	60/3122	106/8144	9.474e-05	0.0008552	0.0005687	MMP15/CREB3L1/ARRB1/PDE4C/CDKN1A/PRKACA/SOST/RXRB/HBEGF/ATF6B/ITPR3/ADCY4/PLCB3/MMP17/EGFR/LRP5/PTH1R/PRKACB/ADCY5/ATF4/MEF2D/MAP2K1/BGLAP/MMP25/PLCB2/VDR/MMP14/RXRA/GNA11/LRP6/CASR/ADCY6/ADCY1/SLC34A2/RUNX2/PDE4A/ADCY9/CYP27B1/ADCY3/FGFR1/GNAI2/ARHGEF1/MEF2A/MMP24/SLC34A1/PRKCA/KL/SLC34A3/GNAI1/PRKCB/ITPR1/GNAS/PDE4B/RXRG/BCL2/FOS/RAF1/AKAP13/PLD1/ARAF	60
KEGG	hsa04728	Dopaminergic synapse	72/3122	132/8144	0.0001018	0.0008946	0.0005949	KCNJ9/CREB3L1/ARRB1/PPP2R5D/PRKACA/PPP2R5A/KIF5A/PPP2R1B/CAMK2A/GNG3/ATF6B/PPP1R1B/ITPR3/PLCB3/SLC6A3/GSK3B/PRKACB/CACNA1A/ADCY5/ATF4/MAPK11/GNG12/GNAL/AKT1/KCNJ5/PPP2R2C/PLCB2/PPP1CA/AKT2/DRD2/CALML4/GRIN2B/GNG5/CAMK2G/CACNA1D/ARNTL/CACNA1B/CACNA1C/KIF5B/MAPK12/GNB4/KCNJ6/PPP2R5B/TH/PPP2R1A/GNAI2/AKT3/GRIN2A/CALML6/PPP3CA/CAMK2B/PRKCA/CALML5/CALM3/PPP2R3C/SLC18A1/CALY/GNAI1/KCNJ3/PRKCB/GNB3/GNB2/SLC18A2/MAOB/ITPR1/CAMK2D/GNG4/GNAS/PPP2R2A/FOS/DRD3/GNG13	72
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	46/3122	77/8144	0.0001075	0.000921	0.0006125	TCF7/ITGA2B/ITGB7/LMNA/JUP/CACNA2D4/ITGA7/CACNA1S/LAMA1/ATP2A3/ITGA2/ITGB4/ACTN3/SLC8A2/ITGA9/DES/CACNA2D2/CACNG6/CACNB3/ITGB3/TCF7L1/ITGA3/SGCD/GJA1/ATP2A1/CACNB1/CACNA1D/DAG1/CACNB4/CACNA1C/CTNNA2/CACNG4/ITGA11/CACNB2/RYR2/CACNA2D1/TCF7L2/CACNA2D3/ITGA6/SGCA/ITGAV/CACNG3/CTNNA1/ITGB5/SGCG/CACNA1F	46
KEGG	hsa04371	Apelin signaling pathway	75/3122	139/8144	0.0001178	0.0009837	0.0006541	SMAD3/NOS1/PRKACA/PDE3B/NOTCH3/GNG3/SERPINE1/PIK3CG/ITPR3/ADCY4/PLCB3/PRKAG1/MYLK2/HDAC5/SPHK2/MYL2/PLIN1/LIPE/MAP2K2/PRKACB/MTOR/ADCY5/MEF2D/MAP2K1/SLC8A2/GNG12/AKT1/ACTA2/PLCB2/CCND1/PLAT/AKT2/HDAC4/ADCY10/MYLK3/CALML4/GNG5/KLF2/MRAS/ADCY6/ADCY1/PRKAG3/RYR1/PIK3R6/NOS3/GNB4/RRAS/ADCY9/RYR2/RPS6KB2/ADCY3/GNAI2/MEF2A/AKT3/SLC9A1/MYL4/UCP1/NRF1/CALML6/PRKAG2/PRKCE/CALML5/CALM3/MYLK/CAMK4/MAP1LC3A/GNAI1/GNB3/GNB2/ITPR1/GNG4/NRAS/MYLK4/RAF1/GNG13	75
KEGG	hsa04934	Cushing syndrome	82/3122	155/8144	0.0001415	0.001152	0.0007663	CYP11A1/TCF7/DVL3/CREB3L1/CDKN1A/PRKACA/KCNK3/WNT3/CAMK2A/MEN1/NR5A1/WNT2B/WNT11/ATF6B/ITPR3/CACNA1S/CACNA1I/ADCY4/PLCB3/WNT16/EGFR/GSK3B/CACNA1H/AXIN1/CDK2/CRHR1/LDLR/SCARB1/AIPL1/MC2R/NR4A1/MAP2K2/WDR5/PRKACB/ADCY5/FZD3/ATF4/MAP2K1/WNT8A/FZD2/DVL1/FZD4/FZD9/CRHR2/PLCB2/CCND1/WNT7A/TCF7L1/CAMK2G/CACNA1D/WNT4/GNA11/CACNA1C/ADCY6/CYP21A2/ADCY1/ORAI1/WNT3A/WNT7B/WNT6/WNT5B/AXIN2/ADCY9/CDK4/ADCY3/GNAI2/E2F1/CAMK2B/TCF7L2/CACNA1G/WNT9A/FZD5/GNAI1/APC/ITPR1/CAMK2D/RAP1B/GNAS/KCNA4/RB1/E2F3/CACNA1F	82
KEGG	hsa04721	Synaptic vesicle cycle	46/3122	78/8144	0.0001656	0.001317	0.0008755	SLC1A3/SLC6A2/AP2M1/CPLX3/SLC6A1/CLTB/ATP6V1F/ATP6V1G2/SLC6A3/DNM2/STX1A/SLC6A13/STX3/ATP6V1A/SLC6A11/ATP6V0E1/UNC13A/CACNA1A/AP2A2/STXBP1/AP2S1/ATP6V0C/DNM1/ATP6V0A1/ATP6V1E1/SLC1A2/CACNA1B/SLC6A4/SLC6A9/CPLX1/ATP6V0E2/TCIRG1/SLC6A7/ATP6V0D1/DNM3/NSF/STX1B/SLC6A12/SLC18A1/SNAP25/SLC1A6/SLC18A2/AP2A1/AP2B1/CPLX2/SLC1A7	46
KEGG	hsa05032	Morphine addiction	52/3122	91/8144	0.0001966	0.001527	0.001015	KCNJ9/ARRB1/PDE4C/PDE2A/PRKACA/PDE3B/GRK5/GNG3/ADCY4/GRK6/GABRB3/GABRA5/PRKACB/CACNA1A/ADCY5/ADORA1/GABRB2/GABBR1/GNG12/KCNJ5/GNG5/GABBR2/PDE1B/GABRG3/CACNA1B/PDE3A/ADCY6/ADCY1/GNB4/KCNJ6/GABRA3/PDE4A/ADCY9/GABRR2/ADCY3/GNAI2/PRKCA/GABRE/GNAI1/KCNJ3/PRKCB/GNB3/GNB2/GNG4/GNAS/GABRP/PDE4B/PDE1C/GRK4/PDE10A/GABRD/GNG13	52
KEGG	hsa04727	GABAergic synapse	51/3122	89/8144	0.0002052	0.001557	0.001036	PRKACA/SLC6A1/GNG3/CACNA1S/ADCY4/SLC6A13/GABRB3/GABRA5/SLC38A3/SLC6A11/PRKACB/CACNA1A/ADCY5/GABRB2/GABBR1/SRC/GNG12/HAP1/GNG5/GABBR2/CACNA1D/GABRG3/CACNA1B/SLC38A1/CACNA1C/ADCY6/ADCY1/GNB4/KCNJ6/GABRA3/ADCY9/GABRR2/NSF/ADCY3/GNAI2/GABARAP/SLC6A12/PRKCA/GABRE/GNAI1/SLC38A5/PRKCB/GNB3/GNB2/GNG4/GABRP/SLC12A5/GABRD/GABARAPL1/GNG13/CACNA1F	51
KEGG	hsa01522	Endocrine resistance	55/3122	98/8144	0.0002473	0.001835	0.00122	TP53/CDKN1A/PRKACA/SHC4/BIK/NOTCH3/NOTCH1/ERBB2/HBEGF/SHC2/ADCY4/PIK3R3/MMP2/EGFR/SHC3/MDM2/NCOR1/SOS2/MAP2K2/PRKACB/MTOR/ADCY5/MAP2K1/MAPK11/SHC1/SRC/BAD/AKT1/CCND1/AKT2/DLL4/ADCY6/ADCY1/MAPK12/ADCY9/RPS6KB2/CDK4/ADCY3/PIK3CA/AKT3/E2F1/CARM1/PIK3R2/NOTCH4/IGF1/IGF1R/GNAS/NRAS/BCL2/FOS/RAF1/RB1/E2F3/PTK2/ARAF	55
KEGG	hsa04662	B cell receptor signaling pathway	47/3122	82/8144	0.000357	0.002592	0.001724	SYK/INPPL1/CD79B/NFATC1/PIK3R3/RELA/GSK3B/PLCG2/IKBKB/VAV2/CD79A/CD22/BCL10/LILRA1/SOS2/MAP2K2/VAV1/MAP2K1/LILRB2/AKT1/CD81/CARD11/LILRB5/PIK3AP1/AKT2/CR2/NFATC2/CD72/LILRB4/PIK3CA/AKT3/LYN/PIK3R2/PPP3CA/RAC1/BTK/PRKCB/RAC3/NFKBIB/VAV3/BLNK/NRAS/CD19/FOS/RAF1/DAPP1/NFKBIE	47
KEGG	hsa04919	Thyroid hormone signaling pathway	65/3122	121/8144	0.0003856	0.00274	0.001822	TP53/PRKACA/RXRB/NOTCH3/NOTCH1/FXYD2/PLCB3/PIK3R3/KAT2A/GSK3B/TSC2/PLCG2/FOXO1/ATP2A3/MYC/PLCD3/MDM2/MED24/NCOR1/MAP2K2/PFKL/PRKACB/MTOR/MAP2K1/PDPK1/SRC/ATP1B1/BAD/AKT1/DIO1/PLCB2/ITGB3/CCND1/AKT2/THRA/RXRA/ATP2A1/NCOA1/SLC2A1/PFKFB2/WNT4/ATP1A2/ATP1A1/ATP1A3/MYH7/MED13/RHEB/PFKP/BMP4/PIK3CA/MED17/MYH6/AKT3/SLC9A1/CREBBP/PIK3R2/ATP1A4/PRKCA/NOTCH4/PRKCB/ITGAV/RXRG/NRAS/GATA4/RAF1	65
KEGG	hsa04972	Pancreatic secretion	56/3122	102/8144	0.0004663	0.003245	0.002158	PLA2G2D/SLC12A2/FXYD2/ITPR3/ADCY4/PLCB3/PNLIPRP2/PLA2G5/ATP2A3/CELA3A/CLCA4/ATP2B2/CCKAR/CTRL/ADCY5/KCNQ1/PLA2G12B/ATP1B1/SLC4A2/PLA2G2F/RAB11A/PLCB2/CELA2B/PLA2G2E/ATP2A1/ATP2B4/RAB27B/ATP1A2/ATP1A1/ADCY6/ADCY1/CPA2/CPA1/SCTR/PRSS3/ATP1A3/PLA2G2A/CEL/ADCY9/RYR2/TPCN2/ADCY3/CD38/CTRB2/SLC9A1/ATP1A4/PRKCA/RAC1/PRKCB/ITPR1/RAP1B/CCK/GNAS/CELA2A/AMY2B/KCNMA1	56
KEGG	hsa05213	Endometrial cancer	35/3122	58/8144	0.0005388	0.003673	0.002442	TP53/TCF7/CDKN1A/ERBB2/PIK3R3/BAK1/EGFR/GSK3B/AXIN1/MYC/SOS2/MAP2K2/MAP2K1/PDPK1/BAD/AKT1/CCND1/GADD45A/TCF7L1/AKT2/CTNNA2/DDB2/AXIN2/PIK3CA/AKT3/PIK3R2/TCF7L2/APC/MLH1/CTNNA1/ELK1/NRAS/EGF/RAF1/ARAF	35
KEGG	hsa04926	Relaxin signaling pathway	68/3122	129/8144	0.0005797	0.003872	0.002575	CREB3L1/ARRB1/RXFP4/NOS1/PRKACA/SHC4/MAP2K7/GNG3/VEGFB/SHC2/ATF6B/ADCY4/PLCB3/PIK3R3/RLN3/RELA/MMP2/EGFR/SHC3/COL1A1/SOS2/MAP2K2/PRKACB/ADCY5/ATF4/MAP2K1/MAPK11/SHC1/SRC/VEGFA/GNG12/AKT1/ACTA2/COL4A2/PLCB2/AKT2/GNG5/COL4A1/TGFBR2/GNA15/EDNRB/ADCY6/TGFB1/VEGFC/ADCY1/PRKCZ/MAPK12/NOS3/GNB4/ADCY9/ADCY3/GNAI2/PIK3CA/AKT3/PIK3R2/PRKCA/INSL5/GNAI1/COL3A1/GNB3/GNB2/GNG4/GNAS/MAP2K4/NRAS/FOS/RAF1/GNG13	68
KEGG	hsa04724	Glutamatergic synapse	61/3122	114/8144	0.0006586	0.004313	0.002868	SLC1A3/GRIK3/PRKACA/HOMER3/GNG3/ITPR3/ADCY4/PLCB3/GRIK4/GRM4/SLC38A3/GRIN2D/PRKACB/CACNA1A/ADCY5/JMJD7-PLA2G4B/GRM6/GNG12/SHANK1/SHANK2/PLCB2/GRM2/GRIN2B/GNG5/SLC1A2/CACNA1D/SLC38A1/CACNA1C/GRIN2C/ADCY6/ADCY1/HOMER2/SHANK3/GNB4/DLGAP1/ADCY9/ADCY3/PLA2G4F/GNAI2/HOMER1/PLA2G4D/GRIN2A/PPP3CA/PRKCA/SLC1A6/GRIN1/GNAI1/GRIK5/KCNJ3/PLA2G4E/PLA2G4B/PRKCB/GNB3/GNB2/ITPR1/GNG4/GNAS/DLG4/GNG13/SLC1A7/PLD1	61
KEGG	hsa04916	Melanogenesis	55/3122	101/8144	0.000682	0.004381	0.002913	TCF7/DVL3/CREB3L1/PRKACA/WNT3/CAMK2A/WNT2B/WNT11/ADCY4/PLCB3/WNT16/GSK3B/MAP2K2/PRKACB/ADCY5/FZD3/MAP2K1/WNT8A/FZD2/DVL1/FZD4/FZD9/PLCB2/WNT7A/TCF7L1/CALML4/CAMK2G/WNT4/EDNRB/ADCY6/ADCY1/WNT3A/WNT7B/WNT6/WNT5B/ADCY9/ASIP/ADCY3/GNAI2/CREBBP/CALML6/CAMK2B/PRKCA/CALML5/CALM3/TCF7L2/WNT9A/FZD5/GNAI1/PRKCB/KITLG/CAMK2D/GNAS/NRAS/RAF1	55
KEGG	hsa05215	Prostate cancer	53/3122	97/8144	0.0007623	0.004804	0.003195	TP53/TCF7/CREB3L1/CDKN1A/INSRR/ERBB2/PIK3R3/RELA/EGFR/GSK3B/FOXO1/IKBKB/CDK2/MDM2/SOS2/MAP2K2/MTOR/ATF4/MAP2K1/PDPK1/BAD/AKT1/CCND1/TCF7L1/PDGFRA/PLAT/AKT2/PDGFB/HSP90AA1/HSP90AB1/FGFR1/PIK3CA/AKT3/E2F1/CREBBP/PIK3R2/AR/ERG/PDGFA/TCF7L2/PDGFC/PDGFRB/IGF1/IGF1R/NRAS/BCL2/EGF/ETV5/SPINT1/RAF1/RB1/E2F3/ARAF	53
KEGG	hsa04971	Gastric acid secretion	43/3122	76/8144	0.0009072	0.005535	0.003681	PRKACA/CAMK2A/ITPR3/ADCY4/PLCB3/MYLK2/PRKACB/ADCY5/KCNQ1/ATP1B1/SLC4A2/PLCB2/MYLK3/CALML4/CAMK2G/KCNJ10/ATP1A2/ATP1A1/ADCY6/ADCY1/ATP1A3/ADCY9/ADCY3/GNAI2/ATP4A/SLC9A1/KCNK10/ATP1A4/HRH2/SLC26A7/CALML6/CAMK2B/PRKCA/CALML5/CALM3/MYLK/GNAI1/PRKCB/ATP4B/ITPR1/CAMK2D/GNAS/MYLK4	43
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	32/3122	53/8144	0.0009114	0.005535	0.003681	AP2M1/PRKACA/CLTB/FXYD2/PLCB3/DNM2/PTH1R/ATP2B2/PRKACB/AP2A2/SLC8A2/ATP1B1/AP2S1/RAB11A/DNM1/PLCB2/VDR/ATP2B4/ATP1A2/ATP1A1/ADCY6/ATP1A3/DNM3/ADCY9/BDKRB2/ATP1A4/PRKCA/KL/PRKCB/AP2A1/GNAS/AP2B1	32
KEGG	hsa00565	Ether lipid metabolism	30/3122	49/8144	0.0009479	0.005653	0.003759	PLA2G2D/PLA2G5/PLD4/PAFAH2/LPCAT4/PLA2G6/PLA2G12B/JMJD7-PLA2G4B/GDPD3/PLA2G2F/PLA2G2E/GDPD1/TMEM189/PLA2G2A/PLA2G4F/PLA2G4D/TMEM189-UBE2V1/TMEM86B/PAFAH1B3/CEPT1/GAL3ST1/PLA2G4E/PLA2G4B/LPCAT1/ENPP2/PLB1/UGT8/PLD3/ENPP6/PLD1	30
KEGG	hsa05219	Bladder cancer	26/3122	41/8144	0.0009736	0.005678	0.003776	TP53/CDKN1A/ERBB2/HBEGF/DAPK3/MMP2/DAPK2/EGFR/MYC/MDM2/RASSF1/MAP2K2/MAP2K1/SRC/VEGFA/CCND1/FGFR3/CDK4/E2F1/DAPK1/NRAS/EGF/RAF1/RB1/E2F3/ARAF	26
KEGG	hsa04022	cGMP-PKG signaling pathway	84/3122	167/8144	0.000986	0.005678	0.003776	CREB3L1/PDE2A/PDE3B/SLC25A31/GTF2IRD1/CNGB1/PIK3CG/ATF6B/FXYD2/ITPR3/CACNA1S/ADCY4/NFATC1/PLCB3/MRVI1/MYLK2/ATP2A3/NPR1/ATP2B2/MAP2K2/ADCY5/ATF4/MEF2D/ADORA1/NPPB/MAP2K1/SLC8A2/KCNMB1/ATP1B1/BAD/AKT1/INSR/PLCB2/ADRA1B/PPP1CA/AKT2/MYLK3/ADRA2A/CALML4/ATP2A1/ROCK2/ATP2B4/CACNA1D/VASP/ATP1A2/GNA11/EDNRB/CACNA1C/PDE3A/ATP1A1/ADCY6/NFATC2/ADCY1/ATP1A3/PIK3R6/NOS3/MYH7/ADCY9/BDKRB2/ADCY3/EDNRA/GNAI2/MEF2A/MYH6/GTF2I/PDE5A/AKT3/ATP1A4/ADRA2B/CALML6/PRKCE/PPP3CA/CALML5/CALM3/MYLK/GNAI1/ITPR1/NPR2/GATA4/MYLK4/RAF1/CACNA1F/ADORA3/KCNMA1	84
KEGG	hsa04144	Endocytosis	120/3122	251/8144	0.00119	0.006735	0.004478	IQSEC1/LDLRAP1/CHMP6/RAB35/SMAD3/AP2M1/ARRB1/PARD6A/EHD2/KIF5A/EPS15L1/GRK5/SNX1/CLTB/ARPC1B/EPN3/VPS4A/ARAP2/SH3GL3/CYTH2/RAB5C/AGAP3/RAB11FIP4/VPS36/SH3GLB2/EGFR/DNM2/EHD4/SPG21/GRK6/LDLR/ARFGAP2/CHMP2A/CAPZB/MDM2/VPS37B/AP2A2/PIP5KL1/HLA-G/FGFR4/SRC/CDC42/GBF1/AP2S1/RAB11A/EPN2/DNM1/IQSEC3/FOLR1/PDGFRA/PIP5K1C/PSD4/ARFGAP1/RAB11FIP3/RAB11FIP2/WWP1/HSPA1B/IGF2R/AGAP2/PDCD6IP/ACTR3B/WIPF3/ACAP3/ARF5/TGFBR2/CAV3/HSPA1L/VPS28/SH3GL1/HSPA6/HLA-F/ARAP3/ASAP3/KIF5B/PRKCZ/DNM3/HGS/SMURF1/SNX2/FGFR3/GIT1/GRK1/EHD3/CXCR4/PIP5K1A/TRAF6/ACAP2/VPS25/AGAP1/RAB11FIP5/EPN1/PML/ARAP1/PSD2/VPS26B/CYTH3/RAB7A/CHMP1A/CBL/AP2A1/IGF1R/RAB11FIP1/GRK4/PARD6G/HSPA8/VPS35/ARFGEF1/ZFYVE27/RAB11B/HSPA1A/ITCH/AP2B1/ARF1/PARD6B/ARPC5L/ZFYVE9/PARD3/CHMP4A/SNX4/PLD1	120
KEGG	hsa05418	Fluid shear stress and atherosclerosis	71/3122	139/8144	0.001392	0.007747	0.005152	TP53/MAPK7/ITGA2B/SQSTM1/BMPR2/TRPV4/ACVR2B/MAP2K7/ASS1/GSTM4/PIK3R3/RELA/MMP2/GSTT2/IKBKB/DUSP1/MAPK11/SRC/VEGFA/AKT1/GSTT2B/ITGB3/TXN2/PLAT/AKT2/GPC1/CALML4/KLF2/PDGFB/CAV3/GSTM3/HSP90AA1/NCF1/KEAP1/PRKCZ/CYBA/SUMO4/MAPK12/MAP3K5/NOS3/MAP2K5/IL1A/BMPR1B/HSP90AB1/ACVR2A/CDH5/BMP4/PIK3CA/MEF2A/AKT3/PIK3R2/GSTO1/CCL2/CALML6/IL1B/CALML5/PDGFA/CALM3/RAC1/RAC3/ARHGEF2/SUMO3/HMOX1/SDC4/ITGAV/GSTA5/MAP2K4/BCL2/FOS/NQO1/PTK2	71
KEGG	hsa04915	Estrogen signaling pathway	70/3122	138/8144	0.001897	0.01014	0.006745	KCNJ9/CREB3L1/PRKACA/SHC4/KRT14/HBEGF/SHC2/ATF6B/ITPR3/ADCY4/PLCB3/PIK3R3/MMP2/EGFR/RARA/SHC3/SOS2/MAP2K2/PRKACB/ADCY5/ATF4/MAP2K1/GABBR1/SHC1/SRC/AKT1/PGR/KCNJ5/CTSD/KRT20/PLCB2/AKT2/CALML4/NCOA1/HSPA1B/GABBR2/HSPA1L/ADCY6/KRT31/ADCY1/HSPA6/HSP90AA1/KRT19/NOS3/KCNJ6/HSP90AB1/ADCY9/ADCY3/GNAI2/PIK3CA/KRT15/AKT3/PIK3R2/CALML6/CALML5/CALM3/KRT35/KRT18/GNAI1/KCNJ3/ITPR1/GNAS/HSPA8/HSPA1A/NRAS/BCL2/TFF1/FOS/RAF1/KRT33B	70
KEGG	hsa04152	AMPK signaling pathway	62/3122	120/8144	0.001904	0.01014	0.006745	CREB3L1/ELAVL1/PPP2R5D/PPP2R5A/AKT1S1/PPP2R1B/PIK3R3/PRKAG1/STK11/TSC2/FBP1/FOXO1/TSC1/SREBF1/LIPE/PFKL/MTOR/LEPR/PDPK1/CPT1A/CAMKK2/AKT1/CPT1B/INSR/PPP2R2C/ULK1/G6PC3/CCND1/CRTC2/AKT2/LEP/RPTOR/PFKFB2/TBC1D1/EEF2/PRKAG3/SLC2A4/PPP2R5B/RPS6KB2/RHEB/PFKP/FASN/PPP2R1A/PIK3CA/AKT3/PIK3R2/HNF4A/SCD5/CPT1C/PRKAG2/EEF2K/PPP2R3C/ADIPOQ/STRADA/IGF1/FBP2/IGF1R/ACACB/PPP2R2A/RAB11B/CCNA2/HMGCR	62
KEGG	hsa04211	Longevity regulating pathway	48/3122	89/8144	0.001913	0.01014	0.006745	TP53/CREB3L1/PRKACA/AKT1S1/SESN2/ATF6B/ADCY4/PIK3R3/PRKAG1/RELA/STK11/TSC2/FOXO1/TSC1/EHMT2/PRKACB/MTOR/ADCY5/ATF4/CAMKK2/AKT1/INSR/ULK1/AKT2/RPTOR/SESN3/SESN1/ADCY6/ADCY1/PRKAG3/EHMT1/ADCY9/RPS6KB2/RHEB/ADCY3/PIK3CA/AKT3/PIK3R2/PRKAG2/SOD2/ADIPOQ/KL/ATG5/CAMK4/IGF1/IGF1R/EIF4E2/NRAS	48
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	52/3122	98/8144	0.002037	0.01063	0.007071	NTRK1/PRKACA/TRPV4/CAMK2A/MAP2K3/ITPR3/ADCY4/PLCB3/PIK3R3/NGF/PLCG2/HTR2C/PRKACB/ADCY5/PLA2G6/JMJD7-PLA2G4B/MAPK11/SRC/PRKCH/PLCB2/TRPV1/PPP1CA/CALML4/CAMK2G/ADCY6/P2RY2/ADCY1/TRPM8/MAPK12/ADCY9/BDKRB2/ADCY3/PLA2G4F/PIK3CA/PLA2G4D/PIK3R2/CALML6/PRKCE/CAMK2B/PRKCA/IL1B/CALML5/CALM3/TRPV3/IGF1/PLA2G4E/PLA2G4B/PRKCB/ITPR1/CAMK2D/GNAS/HRH1	52
KEGG	hsa05218	Melanoma	40/3122	72/8144	0.002157	0.01108	0.00737	TP53/CDKN1A/FGF9/PIK3R3/BAK1/EGFR/MDM2/MAP2K2/MAP2K1/BAD/AKT1/CCND1/GADD45A/PDGFRA/AKT2/PDGFB/DDB2/FGF21/CDK4/FGFR1/PIK3CA/AKT3/E2F1/PIK3R2/FGF8/PDGFA/FGF17/PDGFC/PDGFRB/IGF1/FGF22/FGF6/FGF18/IGF1R/NRAS/EGF/RAF1/RB1/E2F3/ARAF	40
KEGG	hsa04664	Fc epsilon RI signaling pathway	38/3122	68/8144	0.002394	0.01212	0.008057	IL13/SYK/MAP2K7/MAP2K3/PIK3R3/PLCG2/VAV2/ALOX5/SOS2/MAP2K2/VAV1/MAP2K1/JMJD7-PLA2G4B/PDPK1/MAPK11/AKT1/AKT2/MAPK12/PLA2G4F/PIK3CA/PLA2G4D/AKT3/LYN/PIK3R2/PRKCA/CSF2/RAC1/BTK/PLA2G4E/PLA2G4B/RAC3/LCP2/VAV3/MAP2K4/NRAS/IL4/IL3/RAF1	38
KEGG	hsa04973	Carbohydrate digestion and absorption	28/3122	47/8144	0.002492	0.01243	0.008263	HK2/SLC2A5/FXYD2/PLCB3/PIK3R3/HK3/ATP1B1/AKT1/HKDC1/G6PC3/PLCB2/HK1/AKT2/CACNA1D/SLC2A2/ATP1A2/TAS1R2/ATP1A1/ATP1A3/PIK3CA/AKT3/PIK3R2/LCT/ATP1A4/TAS1R3/SLC37A4/PRKCB/AMY2B	28
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	43/3122	79/8144	0.002554	0.01254	0.008342	NRG2/SHC4/ERBB2/SHC2/PIK3R3/EGFR/GSK3B/PLCG2/AXL/SHC3/IL6R/SOS2/MAP2K2/MTOR/MAP2K1/SHC1/SRC/VEGFA/BAD/AKT1/PDGFRA/AKT2/PDGFB/FGFR3/RPS6KB2/PIK3CA/AKT3/PIK3R2/PRKCA/PDGFA/ERBB3/PDGFC/PDGFRB/IGF1/PRKCB/NF1/IGF1R/EIF4E2/NRAS/BCL2/EGF/RAF1/ARAF	43
KEGG	hsa05163	Human cytomegalovirus infection	107/3122	225/8144	0.002655	0.01285	0.008548	TP53/CREB3L1/CDKN1A/PRKACA/GNG3/ATF6B/ITPR3/ADCY4/NFATC1/PLCB3/PIK3R3/IFNA14/RELA/BAK1/EGFR/GSK3B/TSC2/BCAR1/TSC1/IKBKB/IL6R/MYC/MDM2/SOS2/MAP2K2/PRKACB/MTOR/ADCY5/ATF4/MAP2K1/HLA-G/MAPK11/SRC/VEGFA/GNG12/AKT1/PLCB2/ITGB3/CCND1/CRKL/TRADD/PDGFRA/IRF3/AKT2/CALML4/ROCK2/CASP8/TAPBP/GNG5/PTK2B/CCL4/PTGS2/TRAF2/IFNA13/GNA11/ADCY6/NFATC2/ADCY1/PTGER1/HLA-F/MAPK12/GNB4/CX3CL1/ADCY9/RIPK1/RPS6KB2/CXCR4/RHEB/CDK4/ADCY3/PXN/GNAI2/PIK3CA/ARHGEF1/AKT3/E2F1/PIK3R2/CCL2/CALML6/PPP3CA/PRKCA/IL1B/CALML5/CALM3/CRK/RAC1/GNAI1/TAP1/PRKCB/RAC3/GNB3/GNB2/ITGAV/ITPR1/GNG4/GNAS/ELK1/TAP2/NRAS/FAS/RAF1/RB1/GNG13/E2F3/AKAP13/PTK2/ARHGEF12	107
KEGG	hsa04340	Hedgehog signaling pathway	32/3122	56/8144	0.003213	0.01533	0.0102	ARRB1/PRKACA/CSNK1D/MEGF8/HHIP/KIF7/GSK3B/IQCE/PRKACB/SMO/SPOPL/CUL1/CCND1/EFCAB7/EVC/SUFU/GLI2/CSNK1G2/CSNK1A1/SMURF1/IHH/SCUBE2/PTCH1/CCND2/EVC2/GLI3/CSNK1E/HHATL/BCL2/PTCH2/MGRN1/FBXW11	32
KEGG	hsa04260	Cardiac muscle contraction	46/3122	87/8144	0.003934	0.01815	0.01207	TPM2/TNNT2/CACNA2D4/FXYD2/CACNA1S/TNNC1/TPM3/MYL2/ATP2A3/SLC8A2/CACNA2D2/ATP1B1/COX7A1/CACNG6/CACNB3/ATP2A1/CACNB1/CACNA1D/ATP1A2/COX8A/CACNB4/COX7B2/CACNA1C/ATP1A1/TPM4/ATP1A3/CACNG4/MYH7/CACNB2/RYR2/MYH6/HRC/COX6A2/SLC9A1/MYL4/ATP1A4/CACNA2D1/CACNA2D3/UQCRFS1/COX5A/TPM1/COX4I2/COX5B/CACNG3/COX6B1/CACNA1F	46
KEGG	hsa05220	Chronic myeloid leukemia	41/3122	76/8144	0.003942	0.01815	0.01207	TP53/SMAD3/CDKN1A/SHC4/SHC2/PIK3R3/RELA/BAK1/ABL1/IKBKB/BCR/SHC3/MYC/MDM2/SOS2/MAP2K2/MAP2K1/SHC1/BAD/AKT1/CCND1/GADD45A/CRKL/AKT2/CTBP1/TGFBR2/TGFB1/DDB2/CTBP2/CDK4/PIK3CA/AKT3/E2F1/PIK3R2/CRK/CBL/NRAS/RAF1/RB1/E2F3/ARAF	41
KEGG	hsa04930	Type II diabetes mellitus	27/3122	46/8144	0.003967	0.01815	0.01207	HK2/PKLR/PIK3R3/IKBKB/GCK/ABCC8/MTOR/CACNA1A/HK3/INSR/HKDC1/HK1/CACNA1D/SLC2A2/CACNA1B/CACNA1C/PRKCZ/SLC2A4/KCNJ11/CACNA1E/SOCS4/PIK3CA/PIK3R2/PRKCE/CACNA1G/ADIPOQ/SOCS2	27
KEGG	hsa05223	Non-small cell lung cancer	39/3122	72/8144	0.004435	0.02002	0.01331	TP53/CDKN1A/KIF5A/RXRB/ERBB2/JAK3/PIK3R3/BAK1/EGFR/PLCG2/RASSF1/SOS2/MAP2K2/MAP2K1/PDPK1/BAD/AKT1/CCND1/GADD45A/AKT2/RXRA/DDB2/KIF5B/CDK4/PIK3CA/AKT3/E2F1/PIK3R2/RET/PRKCA/PRKCB/RXRG/NRAS/STK4/EGF/RAF1/RB1/E2F3/ARAF	39
KEGG	hsa05230	Central carbon metabolism in cancer	38/3122	70/8144	0.004703	0.02094	0.01393	HK2/TP53/NTRK1/ERBB2/PIK3R3/EGFR/SLC7A5/GCK/MYC/MAP2K2/PFKL/MTOR/HK3/SIRT6/MAP2K1/AKT1/HKDC1/NTRK3/HK1/PDGFRA/AKT2/IDH2/SLC2A1/LDHB/SLC2A2/SLC16A3/FGFR3/PFKP/FGFR1/PIK3CA/AKT3/PIK3R2/RET/FLT3/PDGFRB/SCO2/NRAS/RAF1	38
KEGG	hsa04512	ECM-receptor interaction	46/3122	88/8144	0.005225	0.02267	0.01507	THBS3/ITGA2B/ITGB7/ITGA7/VTN/THBS2/LAMC2/LAMA1/COL1A1/ITGA2/RELN/SV2C/ITGB4/ITGA9/GP1BB/VWF/LAMB3/COL6A3/TNR/COL4A2/ITGB3/ITGA3/LAMA5/COL4A1/TNXB/AGRN/DAG1/GP1BA/TNC/COL9A3/ITGA11/COL6A2/LAMA3/CD47/CD44/FREM2/ITGA6/HSPG2/SDC4/GP9/ITGAV/ITGB5/COL9A1/FRAS1/LAMC3/CHAD	46
KEGG	hsa04540	Gap junction	46/3122	88/8144	0.005225	0.02267	0.01507	MAPK7/PRKACA/CSNK1D/TUBA8/ITPR3/ADCY4/PLCB3/EGFR/HTR2C/SOS2/MAP2K2/PRKACB/ADCY5/TUBA3D/MAP2K1/SRC/PLCB2/PDGFRA/TUBB1/TUBB6/DRD2/GJA1/PDGFB/GNA11/ADCY6/ADCY1/MAP2K5/ADCY9/TUBA3E/TUBAL3/ADCY3/GNAI2/GJD2/PRKCA/PDGFA/LPAR1/PDGFC/PDGFRB/GNAI1/TUBA4A/PRKCB/ITPR1/GNAS/NRAS/EGF/RAF1	46
KEGG	hsa05210	Colorectal cancer	45/3122	86/8144	0.005566	0.02383	0.01585	TP53/TCF7/SMAD3/CDKN1A/PIK3R3/BAK1/EGFR/GSK3B/BIRC5/RALB/AXIN1/MYC/SOS2/MAP2K2/MTOR/MAP2K1/BAD/AKT1/BBC3/CCND1/GADD45A/TCF7L1/AKT2/RALGDS/TGFBR2/TGFB1/DDB2/AXIN2/RPS6KB2/PIK3CA/AKT3/PIK3R2/PMAIP1/TCF7L2/MSH6/RAC1/APC/RAC3/MLH1/NRAS/BCL2/EGF/FOS/RAF1/ARAF	45
KEGG	hsa05030	Cocaine addiction	28/3122	49/8144	0.005688	0.02405	0.01599	CREB3L1/PRKACA/ATF6B/PPP1R1B/RELA/SLC6A3/CDK5/GRIN2D/PRKACB/ADCY5/ATF4/DRD2/BDNF/GRM2/GRIN2B/PDYN/GRIN2C/TH/GNAI2/GRIN2A/GPSM1/SLC18A1/GRIN1/GNAI1/SLC18A2/MAOB/GNAS/DLG4	28
KEGG	hsa04213	Longevity regulating pathway - multiple species	34/3122	62/8144	0.005925	0.02474	0.01645	PRKACA/AKT1S1/CLPB/ADCY4/PIK3R3/PRKAG1/FOXO1/PRKACB/MTOR/ADCY5/AKT1/INSR/AKT2/HSPA1B/RPTOR/HSPA1L/ADCY6/ADCY1/HSPA6/PRKAG3/ADCY9/RPS6KB2/ADCY3/PIK3CA/AKT3/PIK3R2/PRKAG2/SOD2/ATG5/IGF1/IGF1R/HSPA8/HSPA1A/NRAS	34
KEGG	hsa04080	Neuroactive ligand-receptor interaction	162/3122	362/8144	0.006285	0.02592	0.01723	GIPR/GRIK3/CHRNA10/RXFP4/CHRNA4/F2RL3/GRID1/VIPR2/CNR2/HCRT/GZMA/NMB/OPRL1/GALP/GRIK4/NPW/TAC4/RLN3/UTS2R/LTB4R/PTGIR/NTSR2/LTB4R2/GRM4/CRHR1/GABRB3/GABRA5/PTH1R/GALR3/TBXA2R/HTR2C/CCKAR/GH2/MC2R/GRIN2D/PTAFR/LEPR/ADORA1/GH1/GABRB2/SSTR5/HRH4/GABBR1/GRM6/HCRTR1/TSPO/AVPR1B/CRHR2/P2RY6/LPAR3/TRPV1/ADRA1B/GNRH2/NPFF/OXTR/THRA/CHRNA2/LEP/DRD2/ADRA2A/PYY/GRM2/CHRNB1/GRIN2B/GABBR2/PENK/CHRNA3/CHRM1/ADCYAP1R1/LPAR2/P2RX5/CALCRL/GPHA2/GABRG3/VIPR1/AVPR2/ADORA2A/P2RX2/PDYN/TACR2/EDNRB/GRIN2C/P2RY2/GLP2R/PTGER1/GHRH/F2/CHRNG/PPY/SCTR/PRSS3/UCN2/MAS1/CHRM4/ADM2/CHRM2/NTSR1/GABRA3/CHRNB4/GABRR2/PTH2R/GLRA2/BDKRB2/GIP/EDNRA/GPR156/CSH1/CHRNA9/SLURP1/S1PR1/GHR/SSTR3/CHRNA7/GRID2/KISS1/MTNR1B/HRH2/GRIN2A/P2RX1/NMU/ADRA2B/UCN/AVP/CHRNB2/NPY5R/PTGFR/INSL5/TAC3/S1PR3/GHRHR/GABRE/LPAR1/EDN2/GRIN1/MLNR/GRIK5/MCHR1/LYNX1/CHRNE/CALCR/MLN/LPAR6/CCK/NPFFR1/GABRP/GLRB/LHB/NPY/NPY2R/HRH1/S1PR5/CHRND/HTR5A/TAAR8/PRLR/GABRD/CORT/PARD3/DRD3/ADORA3/CALCB/MCHR2	162
KEGG	hsa05031	Amphetamine addiction	37/3122	69/8144	0.006836	0.02761	0.01836	CREB3L1/PRKACA/CAMK2A/ATF6B/PPP1R1B/SLC6A3/ARC/STX1A/GRIN2D/PRKACB/ADCY5/ATF4/PPP1CA/CALML4/GRIN2B/CAMK2G/CACNA1D/PDYN/CACNA1C/GRIN2C/TH/GRIN2A/CALML6/PPP3CA/CAMK2B/PRKCA/CALML5/CALM3/SLC18A1/GRIN1/CAMK4/PRKCB/SLC18A2/MAOB/CAMK2D/GNAS/FOS	37
KEGG	hsa05231	Choline metabolism in cancer	50/3122	98/8144	0.00686	0.02761	0.01836	SLC44A4/PIK3R3/EGFR/TSC2/TSC1/DGKD/SOS2/MAP2K2/MTOR/MAP2K1/JMJD7-PLA2G4B/PDPK1/AKT1/PDGFRA/AKT2/PIP5K1C/RALGDS/SLC5A7/SLC22A1/PDGFB/DGKB/CHKB/DGKZ/RPS6KB2/PIP5K1A/RHEB/PLA2G4F/PIK3CA/PLA2G4D/AKT3/PIK3R2/PRKCA/SLC22A3/PDGFA/PCYT1A/CHKA/RAC1/PDGFC/PDGFRB/LYPLA1/PLA2G4E/PLA2G4B/PRKCB/RAC3/SLC22A5/NRAS/EGF/FOS/RAF1/PLD1	50
KEGG	hsa05135	Yersinia infection	67/3122	137/8144	0.007107	0.02826	0.01879	LCK/ELMO2/ARHGEF7/MAP2K7/TICAM1/ARPC1B/CD4/MAP2K3/LIMK1/ZAP70/CD8B/NFATC1/PIK3R3/RELA/GSK3B/BCAR1/IKBKB/VAV2/MAP2K2/VAV1/MAP2K1/MAPK11/SRC/CDC42/AKT1/RPS6KA2/RHOG/CRKL/IRF3/NLRP3/AKT2/PIP5K1C/IL2/DOCK1/ROCK2/PKN1/PTK2B/ACTR3B/WIPF3/TRAF2/NFATC2/IL10/MAPK12/PIP5K1A/PXN/CD8A/PIK3CA/ARHGEF1/TRAF6/AKT3/PIK3R2/CCL2/CASP1/PYCARD/IL1B/RPS6KA3/CRK/RAC1/RAC3/BAIAP2/LCP2/VAV3/MAP2K4/ARPC5L/FOS/PTK2/ARHGEF12	67
KEGG	hsa04720	Long-term potentiation	36/3122	67/8144	0.007265	0.02835	0.01885	PRKACA/CAMK2A/ITPR3/PLCB3/MAP2K2/GRIN2D/PRKACB/ATF4/MAP2K1/RPS6KA2/PLCB2/PPP1CA/CALML4/GRIN2B/CAMK2G/CACNA1C/GRIN2C/ADCY1/CREBBP/GRIN2A/CALML6/PPP3CA/CAMK2B/PRKCA/CALML5/CALM3/RPS6KA3/GRIN1/CAMK4/PRKCB/ITPR1/CAMK2D/RAP1B/NRAS/RAF1/ARAF	36
KEGG	hsa01250	Biosynthesis of nucleotide sugars	22/3122	37/8144	0.007299	0.02835	0.01885	HK2/MPI/TSTA3/GCK/PMM1/GALK1/GALT/HK3/MIOX/HKDC1/CMAS/HK1/GPI/UAP1L1/UXS1/GFPT2/GALE/TGDS/PMM2/UGDH/PGM3/GMPPA	22
KEGG	hsa00051	Fructose and mannose metabolism	20/3122	33/8144	0.007758	0.02978	0.01981	HK2/MPI/ALDOC/ALDOA/TSTA3/FBP1/AKR1B1/PMM1/PFKL/HK3/TPI1/HKDC1/HK1/KHK/PFKFB2/PFKP/AKR1B10/PMM2/FBP2/GMPPA	20
KEGG	hsa00592	alpha-Linolenic acid metabolism	16/3122	25/8144	0.008197	0.03111	0.02069	FADS2/ACOX3/PLA2G2D/PLA2G5/PLA2G6/PLA2G12B/JMJD7-PLA2G4B/PLA2G2F/PLA2G2E/PLA2G2A/PLA2G4F/PLA2G4D/PLA2G4E/ACOX1/PLA2G4B/PLB1	16
KEGG	hsa04330	Notch signaling pathway	32/3122	59/8144	0.009248	0.0347	0.02308	DVL3/RFNG/APH1A/ATXN1L/DTX3/NOTCH3/NOTCH1/NCOR2/DTX1/KAT2A/TLE3/PSENEN/LFNG/TLE2/PTCRA/DVL1/HEYL/DTX2/TLE1/CTBP1/PSEN1/DLL4/NUMBL/CTBP2/CREBBP/RBPJ/NOTCH4/HES1/TLE6/RBPJL/ATXN1/NUMB	32
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	49/3122	97/8144	0.009379	0.03481	0.02315	SYK/SCIN/INPPL1/ARPC1B/LIMK1/PIK3R3/SPHK2/PLCG2/DNM2/VAV2/CFL1/MARCKS/VAV1/PLA2G6/MAP2K1/JMJD7-PLA2G4B/CDC42/AKT1/CRKL/AKT2/PIP5K1C/DOCK1/ACTR3B/VASP/GSN/NCF1/ASAP3/MARCKSL1/RPS6KB2/PIP5K1A/PLA2G4F/PIK3CA/PLA2G4D/AKT3/LYN/PIK3R2/PRKCE/PRKCA/CRK/RAC1/PLA2G4E/PLA2G4B/PRKCB/VAV3/MYO10/ARPC5L/RAF1/FCGR3A/PLD1	49
KEGG	hsa04660	T cell receptor signaling pathway	52/3122	104/8144	0.009767	0.03585	0.02384	LCK/MAP2K7/CD4/PAK6/NCK1/ZAP70/CD8B/NFATC1/PIK3R3/RELA/GSK3B/IKBKB/VAV2/BCL10/SOS2/MAP2K2/VAV1/MAP2K1/PDPK1/MAPK11/CDC42/AKT1/CARD11/AKT2/IL2/RASGRP1/NFATC2/GRAP2/IL10/MAPK12/CD28/NCK2/PAK2/PAK4/CDK4/CD8A/PIK3CA/AKT3/PIK3R2/PDCD1/PPP3CA/CSF2/PAK3/NFKBIB/LCP2/VAV3/MAP3K14/NRAS/IL4/FOS/RAF1/NFKBIE	52
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	98/3122	212/8144	0.01061	0.0385	0.02561	CREB3L1/ARRB1/CHRNA4/PRKACA/RXRB/GSTM4/ATF6B/FGF9/CACNA1S/ADCY4/PIK3R3/NR1I3/RELA/GSTT2/EGFR/BIRC5/MYC/AIPL1/SOS2/MAP2K2/PRKACB/CDC25A/MTOR/CACNA1A/ADCY5/PAQR7/ATF4/MAP2K1/SRC/VEGFA/BAD/AKT1/GSTT2B/PGR/EPHX3/RPS6KA2/CCND1/EPHX1/VDR/AKT2/CYP3A4/RXRA/DLL4/CHRNA3/CACNA1D/KPNA2/CACNA1B/GSTM3/CACNA1C/MIR141/ADCY6/ADCY1/HSP90AA1/HSP90AB1/CHRNB4/ADCY9/UGT2B15/RPS6KB2/ADCY3/GNAI2/CHRNA9/PIK3CA/CHRNA7/AKT3/E2F1/PIK3R2/AR/FGF8/GSTO1/CYP1B1/CHRNB2/PRKCA/PAQR5/RPS6KA3/FGF17/GNAI1/PRKCB/UGT1A1/FGF22/UGT2A1/FGF6/MIRLET7A1/GSTA5/FGF18/UGT2B17/GNAS/RXRG/CYP1A2/NRAS/UGT2A3/BCL2/EGF/FOS/RAF1/RB1/CACNA1F/KPNA5/KLF4	98
KEGG	hsa04066	HIF-1 signaling pathway	54/3122	109/8144	0.01076	0.03863	0.02569	HK2/CDKN1A/ALDOC/ALDOA/CAMK2A/ERBB2/SERPINE1/PIK3R3/RELA/CUL2/EGFR/PLCG2/ANGPT2/IL6R/ENO3/MAP2K2/PFKL/MTOR/HK3/MAP2K1/VEGFA/AKT1/INSR/HKDC1/HK1/AKT2/SLC2A1/LDHB/CAMK2G/FLT1/NOS3/RPS6KB2/PFKP/MKNK2/PIK3CA/AKT3/ANGPT1/CREBBP/PIK3R2/EGLN2/TF/CAMK2B/PRKCA/VHL/IGF1/PRKCB/HMOX1/CAMK2D/IGF1R/EIF4E2/BCL2/EGF/LTBR/ENO2	54
KEGG	hsa04150	mTOR signaling pathway	74/3122	156/8144	0.012	0.0422	0.02806	DVL3/PRR5L/AKT1S1/TELO2/WNT3/WNT2B/SESN2/PRR5/WNT11/ATP6V1F/SEC13/ATP6V1G2/WNT16/PIK3R3/STK11/GSK3B/TSC2/TSC1/IKBKB/LRP5/SLC7A5/ATP6V1A/SOS2/MAP2K2/MTOR/SLC3A2/FZD3/MAP2K1/PDPK1/WNT8A/FZD2/DVL1/AKT1/FZD4/FZD9/INSR/RPS6KA2/ULK1/WNT7A/ATP6V1E1/AKT2/GRB10/RPTOR/WNT4/MLST8/LRP6/RRAGD/WNT3A/WNT7B/WNT6/MIOS/WNT5B/WDR24/RPS6KB2/RHEB/PIK3CA/AKT3/PIK3R2/ULK2/PRKCA/RPS6KA3/RRAGA/WNT9A/STRADA/FZD5/IGF1/LPIN1/PRKCB/IGF1R/FLCN/EIF4E2/NRAS/RAF1/SGK1	74
KEGG	hsa04218	Cellular senescence	74/3122	156/8144	0.012	0.0422	0.02806	CHEK2/TP53/SMAD3/CDKN1A/SQSTM1/MAPKAPK2/TRPV4/SLC25A31/MAP2K3/SERPINE1/CCNB2/ITPR3/NFATC1/PIK3R3/RELA/TSC2/FOXO1/TSC1/CDK2/MYC/MDM2/MAP2K2/CAPN1/CDC25A/MTOR/MAP2K1/HLA-G/MAPK11/AKT1/CCND1/GADD45A/PPP1CA/AKT2/CALML4/CACNA1D/TGFBR2/MRAS/HIPK4/TGFB1/NFATC2/HLA-F/MAPK12/IL1A/RRAS/ATM/RAD9A/RHEB/CDK4/CCND2/PIK3CA/FOXM1/E2F4/AKT3/E2F1/PIK3R2/CALML6/PPP3CA/CALML5/CALM3/CHEK1/E2F5/ITPR1/RBL1/RBBP4/LIN9/TRPM7/NRAS/GATA4/CCNA2/RAF1/RB1/E2F3/FBXW11/LIN54	74
KEGG	hsa04924	Renin secretion	36/3122	69/8144	0.0131	0.04552	0.03027	PRKACA/PDE3B/ITPR3/CACNA1S/PLCB3/REN/CTSB/NPR1/CLCA4/PRKACB/ADCY5/ADORA1/PLCB2/CALML4/CACNA1D/ADCYAP1R1/PDE1B/CACNA1C/PDE3A/AQP1/ADCY6/ORAI1/EDNRA/GNAI2/CALML6/PPP3CA/CALML5/CALM3/ACE/EDN2/GNAI1/ITPR1/GNAS/PDE1C/CACNA1F/KCNMA1	36
KEGG	hsa04062	Chemokine signaling pathway	89/3122	192/8144	0.01322	0.04552	0.03027	ARRB1/PRKACA/GRK5/SHC4/GNG3/JAK3/SHC2/PIK3CG/ADCY4/PLCB3/PIK3R3/RELA/GSK3B/PLCG2/BCAR1/IKBKB/SHC3/VAV2/GRK6/SOS2/VAV1/PRKACB/ADCY5/FGR/MAP2K1/SHC1/SRC/GNG12/CDC42/BAD/AKT1/CXCR5/PLCB2/CRKL/AKT2/CCL19/ROCK2/GNG5/STAT2/PTK2B/CCL4/CCR9/XCR1/CCR7/ADCY6/ADCY1/CCL24/NCF1/PRKCZ/PIK3R6/GNB4/CX3CL1/ADCY9/GRK1/CXCR4/ADCY3/PXN/GNAI2/PIK3CA/CCR6/AKT3/LYN/CXCL3/PIK3R2/CCL2/CCL1/CRK/RAC1/GNAI1/CCL16/PRKCB/RAC3/GNB3/NFKBIB/GNB2/CXCL5/RAP1B/GNG4/CXCR3/GRK4/VAV3/CCL13/CCL25/NRAS/PARD3/RAF1/GNG13/PTK2/CCL27	89
KEGG	hsa04927	Cortisol synthesis and secretion	34/3122	65/8144	0.01492	0.05084	0.03381	CYP11A1/CREB3L1/PRKACA/KCNK3/NR5A1/ATF6B/ITPR3/CACNA1S/CACNA1I/ADCY4/PLCB3/CACNA1H/LDLR/SCARB1/MC2R/NR4A1/PRKACB/ADCY5/ATF4/PLCB2/CACNA1D/GNA11/CACNA1C/ADCY6/CYP21A2/ADCY1/ORAI1/ADCY9/ADCY3/CACNA1G/ITPR1/GNAS/KCNA4/CACNA1F	34
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	21/3122	37/8144	0.01734	0.05792	0.03852	FXYD2/PIK3R3/PDPK1/ATP1B1/INSR/FXYD4/ATP1A2/HSD11B2/SCNN1G/ATP1A1/ATP1A3/PIK3CA/SCNN1A/PIK3R2/ATP1A4/PRKCA/IGF1/PRKCB/SLC9A3R2/SCNN1B/SGK1	21
KEGG	hsa05216	Thyroid cancer	21/3122	37/8144	0.01734	0.05792	0.03852	TP53/TCF7/NTRK1/CDKN1A/RXRB/BAK1/TPM3/MYC/MAP2K2/MAP2K1/CCND1/GADD45A/TFG/TCF7L1/RXRA/DDB2/RET/TCF7L2/RXRG/NRAS/PAX8	21
KEGG	hsa00564	Glycerophospholipid metabolism	48/3122	98/8144	0.01988	0.06576	0.04373	PNPLA6/ETNK2/GPD1/PLA2G15/PLA2G2D/CDIPT/PLA2G5/PLD4/PISD/DGKD/LPCAT4/PNPLA7/PLA2G6/PTDSS2/PLA2G12B/ACHE/JMJD7-PLA2G4B/MBOAT2/AGPAT2/PLA2G2F/LCAT/PLA2G2E/AGPAT4/LYPLA2/PGS1/PHOSPHO1/DGKB/PLA2G2A/PEMT/CHKB/GPD1L/DGKZ/PLA2G4F/PLA2G4D/CEPT1/PCYT1A/CHKA/CDS2/LYPLA1/LPIN1/PLA2G4E/PLA2G4B/LPCAT1/MBOAT1/AGPAT3/PLB1/PLD3/PLD1	48
KEGG	hsa04530	Tight junction	78/3122	169/8144	0.02182	0.07146	0.04752	ACTN4/PARD6A/PRKACA/PPP2R1B/MAP2K7/CLDN5/ARPC1B/ERBB2/TUBA8/LLGL2/CGN/AMOT/PRKAG1/STK11/SYNPO/SCRIB/MYL2/AMOTL1/MYH9/AMOTL2/HSPA4/PRKACB/CLDN7/ARHGEF18/TUBA3D/SRC/CDC42/ARHGAP17/OCLN/PPP2R2C/CCND1/CTTN/MAP3K1/RAPGEF6/ACTN1/JAM3/ROCK2/TJAP1/CACNA1D/ACTR3B/JAM2/VASP/MPP4/PRKAG3/TJP3/PRKCZ/MAP3K5/CLDN14/TUBA3E/TUBAL3/CDK4/CLDN10/PPP2R1A/MYH14/MYL6B/MYH10/CD1A/CD1D/PRKAG2/PRKCE/RAB13/CLDN6/RAC1/MYL6/CLDN19/CGNL1/TUBA4A/ARHGEF2/MICALL2/CLDN18/PARD6G/PPP2R2A/GATA4/PARD6B/ARPC5L/PARD3/SYMPK/CD1B	78
KEGG	hsa04726	Serotonergic synapse	55/3122	115/8144	0.02305	0.07476	0.04971	KCNJ9/PTGS1/PRKACA/GNG3/ITPR3/CACNA1S/PLCB3/DUSP1/GABRB3/ALOX5/HTR2C/ALOX12B/PRKACB/CACNA1A/ADCY5/GABRB2/MAP2K1/JMJD7-PLA2G4B/GNG12/KCNJ5/PLCB2/GNG5/CACNA1D/PTGS2/CACNA1B/ALOX15B/SLC6A4/CACNA1C/GNB4/KCNJ6/PLA2G4F/GNAI2/PLA2G4D/PRKCA/SLC18A1/GNAI1/KCNJ3/HTR3C/PLA2G4E/PLA2G4B/PRKCB/GNB3/GNB2/SLC18A2/MAOB/ITPR1/GNG4/GNAS/NRAS/HTR5A/HTR3A/RAF1/GNG13/CACNA1F/ARAF	55
KEGG	hsa04730	Long-term depression	31/3122	60/8144	0.02402	0.0764	0.05081	NOS1/PPP2R1B/GNAZ/ITPR3/PLCB3/CRHR1/MAP2K2/CACNA1A/MAP2K1/JMJD7-PLA2G4B/PLCB2/GNA11/RYR1/PPP2R1A/PLA2G4F/GNAI2/PLA2G4D/LYN/GRID2/PRKCA/IGF1/GNAI1/PLA2G4E/PLA2G4B/PRKCB/ITPR1/IGF1R/GNAS/NRAS/RAF1/ARAF	31
KEGG	hsa04978	Mineral absorption	31/3122	60/8144	0.02402	0.0764	0.05081	SLC26A6/FXYD2/SLC46A1/MT1F/SLC26A9/ATP2B2/MT1B/SLC39A4/SLC8A2/ATP1B1/SLC9A3/STEAP1/VDR/ATP2B4/ATP1A2/FTH1/FTL/SLC6A19/HEPHL1/ATP1A1/SLC34A2/ATP1A3/SLC30A1/TRPV6/SLC34A1/ATP1A4/TF/SLC34A3/CLCN2/HMOX1/TRPM7	31
KEGG	hsa05212	Pancreatic cancer	38/3122	76/8144	0.0248	0.07776	0.05171	TP53/SMAD3/CDKN1A/BRCA2/ERBB2/PIK3R3/RELA/BAK1/EGFR/IKBKB/RALB/MTOR/MAP2K1/VEGFA/CDC42/BAD/AKT1/CCND1/GADD45A/AKT2/RALGDS/TGFBR2/TGFB1/DDB2/RPS6KB2/CDK4/PIK3CA/AKT3/E2F1/PIK3R2/RAC1/RAC3/EGF/RAF1/RB1/E2F3/PLD1/ARAF	38
KEGG	hsa00120	Primary bile acid biosynthesis	11/3122	17/8144	0.02491	0.07776	0.05171	ACOT8/CYP27A1/AKR1C4/SLC27A5/CYP7A1/CYP7B1/CYP46A1/SCP2/CYP8B1/HSD17B4/HSD3B7	11
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	26/3122	49/8144	0.02518	0.07788	0.05179	HK2/MPI/AMDHD2/TSTA3/CYB5R2/CYB5R4/GNPDA2/GCK/PMM1/GALK1/GALT/HK3/HKDC1/CMAS/HK1/GPI/UAP1L1/UXS1/GFPT2/CYB5R3/GALE/PMM2/UGDH/PGM3/CHIT1/GMPPA	26
KEGG	hsa05221	Acute myeloid leukemia	34/3122	67/8144	0.02548	0.07807	0.05192	TCF7/JUP/PIK3R3/RELA/IKBKB/PER2/RARA/PPARD/MYC/ZBTB16/SOS2/MAP2K2/MTOR/MAP2K1/BAD/AKT1/CCND1/TCF7L1/AKT2/SPI1/RPS6KB2/PIK3CA/AKT3/PIK3R2/FLT3/TCF7L2/PML/CSF2/CSF1R/NRAS/IL3/CCNA2/RAF1/ARAF	34
KEGG	hsa03250	Viral life cycle - HIV-1	32/3122	63/8144	0.0292	0.08867	0.05896	APOBEC3F/TNPO3/CHMP6/CD4/SMARCB1/BICD2/CDK9/VPS4A/PIN1/KAT2A/ELL/FEZ1/FURIN/APOBEC3D/PDCD6IP/MAP1B/ELL3/MLLT3/HGS/CXCR4/SERINC5/XPO1/CREBBP/MX1/ELL2/SUPT4H1/CPSF6/BST2/MAP1S/CHMP4A/MLLT1/MX2	32
KEGG	hsa03320	PPAR signaling pathway	37/3122	75/8144	0.03345	0.1007	0.06694	APOA5/FADS2/ACOX3/RXRB/CYP27A1/SLC27A4/PLTP/SLC27A5/ACSL6/PPARD/PLIN1/APOC3/PDPK1/CYP7A1/CPT1A/CPT1B/APOA2/ACSBG1/RXRA/ME1/FABP6/SLC27A6/UCP1/ME3/SCD5/SCP2/CPT1C/CYP8B1/SLC27A1/PLIN4/ADIPOQ/SORBS1/ACSBG2/ACOX1/PLIN2/RXRG/NR1H3	37
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	201/3122	476/8144	0.04049	0.1194	0.07939	CSNK2B/DVL3/CSF1/GPX2/ATXN1L/GPX1/NOS1/SQSTM1/KIF5A/ACTR1B/WNT3/CAMK2A/MAP2K7/SLC25A31/KLC4/WNT2B/NDUFA13/NDUFV1/NDUFA8/WNT11/MAP2K3/NDUFA11/HTT/TUBA8/NDUFA7/NDUFA6/ITPR3/NDUFS5/CACNA1S/PLCB3/PSMB4/WNT16/DNAI2/TANK/RELA/BAK1/SLC6A3/GSK3B/DNAH14/GPX3/LRP5/DNAI1/NDUFB7/STX1A/ATP2A3/AXIN1/CDK5/HIP1/AGER/KLC2/MAP2K2/WIPI2/GRIN2D/TNFRSF1B/CAPN1/MTOR/TUBA3D/FZD3/ATF4/MAP2K1/NDUFS7/MAPK11/WNT8A/FZD2/DVL1/NDUFS2/DNAH17/BAD/FZD4/FZD9/COX7A1/PSMB6/DNAH2/SPTBN2/ULK1/DCTN1/NDUFS3/PLCB2/PINK1/CCS/WNT7A/SDHC/MAP3K10/HAP1/TUBB1/DNAH1/PSMD8/TUBB6/MAPT/UCHL1/NDUFS6/BDNF/UBE2J2/CALML4/ATP2A1/CASP8/TOMM40/PSEN1/GRIN2B/MFN2/DAXX/CAMK2G/CHRM1/CACNA1D/WNT4/KLC3/PTGS2/DNAH10/TRAF2/CACNA1B/COX8A/PDYN/NOX4/NDUFA3/COX7B2/LRP6/CACNA1C/GRIN2C/ACTR10/DNAL4/WNT3A/ATXN2/WNT7B/CSNK1A1/RYR1/KIF5B/WNT6/MAPK12/MAP3K5/WNT5B/ADRM1/DNAH11/IL1A/AXIN2/ATXN2L/RYR2/TUBA3E/PSMC6/TUBAL3/NDUFC2/UBE2L3/CHRNA7/COX6A2/TOMM40L/DNAH3/GRIN2A/ULK2/AMBRA1/PSMD7/ATXN3L/CALML6/DNALI1/PPP3CA/CAMK2B/PRKCA/IL1B/CALML5/NDUFA4/CALM3/NDUFC1/NDUFA12/WNT9A/PSMA1/RAC1/UQCRFS1/SNCA/FZD5/GRIN1/MAP1LC3A/CSNK1E/NRBF2/NDUFS8/APC/TUBA4A/PRKCB/SDHB/COX5A/COX4I2/KLC1/ITPR1/PSMC5/ATG2B/DKK2/CAMK2D/COX5B/ATXN1/SDHA/COX6B1/ATXN3/NRAS/ERN1/DCTN6/BCL2/FAS/UBA1/PARK7/RAF1/DLG4/CACNA1F/PSMD9/ARAF	201
KEGG	hsa04625	C-type lectin receptor signaling pathway	49/3122	104/8144	0.04098	0.1194	0.07939	IRF9/SYK/BCL3/MAPKAPK2/CARD9/LSP1/ITPR3/CLEC4E/NFATC1/PIK3R3/RELA/PLCG2/RELB/IKBKB/BCL10/MDM2/MAPK11/SRC/IL17D/AKT1/NLRP3/AKT2/IL2/CALML4/CASP8/STAT2/PTGS2/KSR1/MRAS/NFATC2/IL10/MAPK12/RRAS/PIK3CA/AKT3/CLEC4M/PIK3R2/CASP1/CALML6/PPP3CA/PYCARD/IL1B/CALML5/CALM3/ITPR1/MAP3K14/NRAS/RAF1/ARHGEF12	49
KEGG	hsa04920	Adipocytokine signaling pathway	34/3122	69/8144	0.04111	0.1194	0.07939	RXRB/PRKAG1/RELA/STK11/ACSL6/IKBKB/AGRP/TNFRSF1B/MTOR/LEPR/CPT1A/CAMKK2/AKT1/CPT1B/G6PC3/TRADD/AKT2/LEP/ACSBG1/RXRA/SLC2A1/TRAF2/PRKAG3/SLC2A4/AKT3/CPT1C/PRKAG2/ADIPOQ/ACSBG2/NFKBIB/ACACB/NPY/RXRG/NFKBIE	34
KEGG	hsa05211	Renal cell carcinoma	34/3122	69/8144	0.04111	0.1194	0.07939	CDKN1A/PAK6/PIK3R3/CUL2/SOS2/MAP2K2/MAP2K1/VEGFA/CDC42/BAD/AKT1/CRKL/AKT2/SLC2A1/ARNT2/PDGFB/TGFB1/EPAS1/PAK2/PAK4/PIK3CA/AKT3/CREBBP/PIK3R2/EGLN2/VHL/PAK3/CRK/RAC1/RAP1B/FLCN/NRAS/RAF1/ARAF	34
KEGG	hsa00511	Other glycan degradation	11/3122	18/8144	0.04219	0.1215	0.08077	NEU1/NEU2/MAN2B1/MAN2B2/ENGASE/GBA/GBA2/NEU4/FUCA2/MAN2C1/GLB1	11
KEGG	hsa00052	Galactose metabolism	17/3122	31/8144	0.04545	0.1297	0.08628	HK2/AKR1B1/GCK/GALK1/PFKL/GALT/HK3/HKDC1/G6PC3/HK1/B4GALT2/GAA/PFKP/LCT/GALE/AKR1B10/GLB1	17
KEGG	hsa04071	Sphingolipid signaling pathway	55/3122	119/8144	0.04686	0.1321	0.08783	TP53/PPP2R5D/PPP2R5A/PPP2R1B/PLCB3/PIK3R3/RELA/SGPP1/ASAH1/ABCC1/SPHK2/MAP2K2/ADORA1/MAP2K1/PDPK1/MAPK11/AKT1/CTSD/PPP2R2C/PLCB2/TRADD/AKT2/ROCK2/SPTLC1/TRAF2/ACER1/PRKCZ/NSMAF/MAPK12/MAP3K5/NOS3/PPP2R5B/SPTLC3/BDKRB2/PPP2R1A/GNAI2/PIK3CA/S1PR1/AKT3/PIK3R2/PRKCE/PRKCA/PPP2R3C/S1PR3/RAC1/GNAI1/PRKCB/RAC3/PPP2R2A/NRAS/S1PR5/BCL2/RAF1/ADORA3/PLD1	55
KEGG	hsa04068	FoxO signaling pathway	60/3122	131/8144	0.04734	0.1321	0.08783	SMAD3/BNIP3/CDKN1A/HOMER3/CCNB2/PLK1/PIK3R3/PRKAG1/STK11/EGFR/FOXO1/IKBKB/CDK2/MDM2/SOS2/MAP2K2/MAP2K1/PDPK1/MAPK11/AKT1/INSR/G6PC3/CCND1/GADD45A/AKT2/AGAP2/KLF2/TGFBR2/TGFB1/PRKAG3/PRMT1/HOMER2/IL10/SLC2A4/MAPK12/ATG12/ATM/CCND2/HOMER1/PIK3CA/S1PR1/AKT3/GABARAP/CREBBP/PIK3R2/PRKAG2/NLK/SOD2/IGF1/USP7/CSNK1E/RAG2/IGF1R/NRAS/STK4/EGF/RAF1/GABARAPL1/SGK1/ARAF	60
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	65/3122	143/8144	0.04745	0.1321	0.08783	TCF7/DVL3/SMAD3/BMPR2/ACVR2B/WNT3/WNT2B/TCF3/WNT11/JAK3/LIF/LEFTY1/LEFTY2/WNT16/PIK3R3/GSK3B/AXIN1/MYC/HOXB1/MAP2K2/FZD3/MAP2K1/FGFR4/MAPK11/WNT8A/FZD2/DVL1/AKT1/FZD4/FZD9/WNT7A/AKT2/WNT4/WNT3A/WNT7B/PCGF1/ZFHX3/WNT6/MAPK12/WNT5B/AXIN2/BMPR1B/FGFR3/ACVR2A/SMAD1/FGFR1/BMP4/PIK3CA/PCGF3/AKT3/PIK3R2/ID3/WNT9A/FZD5/IGF1/APC/ESRRB/IGF1R/HOXA1/POU5F1/NRAS/REST/PCGF2/RAF1/KLF4	65
KEGG	hsa04723	Retrograde endocannabinoid signaling	67/3122	148/8144	0.04881	0.1338	0.089	KCNJ9/PRKACA/GNG3/NDUFA13/NDUFV1/NDUFA8/NDUFA11/NDUFA7/NDUFA6/ITPR3/NDUFS5/CACNA1S/ADCY4/PLCB3/NDUFB7/GABRB3/GABRA5/PRKACB/CACNA1A/ADCY5/GABRB2/NDUFS7/MAPK11/GNG12/NDUFS2/KCNJ5/NDUFS3/PLCB2/NDUFS6/MGLL/DAGLA/GNG5/CACNA1D/PTGS2/GABRG3/CACNA1B/ABHD6/NDUFA3/CACNA1C/ADCY6/ADCY1/MAPK12/GNB4/KCNJ6/GABRA3/ADCY9/GABRR2/ADCY3/GNAI2/NDUFC2/PRKCA/NDUFA4/NDUFC1/NDUFA12/GABRE/GNAI1/NDUFS8/KCNJ3/PRKCB/GNB3/GNB2/ITPR1/GNG4/GABRP/GABRD/GNG13/CACNA1F	67
KEGG	hsa04210	Apoptosis	62/3122	136/8144	0.04889	0.1338	0.089	TP53/DFFB/NTRK1/LMNA/TUBA8/ITPR3/DAB2IP/PIK3R3/NGF/RELA/BAK1/IKBKB/CTSS/BIRC5/LMNB2/CTSB/PRF1/MAP2K2/ENDOG/CAPN1/TUBA3D/ATF4/MAP2K1/PDPK1/BAD/AKT1/CTSD/CASP10/BBC3/GADD45A/TRADD/AKT2/HRK/CASP8/DAXX/TRAF2/MAP3K5/ATM/RIPK1/TUBA3E/TUBAL3/SPTAN1/PIK3CA/AKT3/DFFA/PIK3R2/PMAIP1/CTSK/AIFM1/TP53AIP1/TUBA4A/ITPR1/TNFRSF10A/TNFRSF10B/MAP3K14/NRAS/ERN1/IL3/BCL2/FAS/FOS/RAF1	62
KEGG	hsa04923	Regulation of lipolysis in adipocytes	28/3122	56/8144	0.04948	0.1344	0.08935	PTGS1/PRKACA/PDE3B/ADCY4/PIK3R3/NPR1/PLIN1/LIPE/PRKACB/ADCY5/ADORA1/AKT1/INSR/PNPLA2/AKT2/MGLL/PTGS2/ADCY6/ADCY1/ADCY9/ADCY3/GNAI2/PIK3CA/AKT3/PIK3R2/GNAI1/GNAS/NPY	28
KEGG	hsa05340	Primary immunodeficiency	20/3122	38/8144	0.05109	0.1368	0.09097	LCK/CD4/JAK3/ZAP70/CD8B/CD79A/AIRE/ORAI1/CD8A/CD40/BTK/CIITA/TAP1/RAG2/TNFRSF13C/TAP2/BLNK/DCLRE1C/CD19/AICDA	20
KEGG	hsa04917	Prolactin signaling pathway	34/3122	70/8144	0.0512	0.1368	0.09097	SHC4/SHC2/ELF5/PIK3R3/RELA/GSK3B/SHC3/GCK/SOS2/MAP2K2/GALT/MAP2K1/MAPK11/SHC1/SRC/CISH/AKT1/CCND1/AKT2/SLC2A2/MAPK12/TH/CCND2/SOCS5/SOCS4/PIK3CA/AKT3/PIK3R2/SOCS2/LHB/NRAS/PRLR/FOS/RAF1	34
KEGG	hsa04966	Collecting duct acid secretion	15/3122	27/8144	0.05171	0.1371	0.09115	ATP6V1F/ATP6V1G2/CLCNKB/ATP6V1A/ATP6V0E1/ATP6V0C/ATP6V0A1/ATP6V1E1/ATP6V0E2/TCIRG1/SLC4A1/ATP6V0D1/ATP4A/SLC12A7/ATP4B	15
KEGG	hsa04931	Insulin resistance	50/3122	108/8144	0.05439	0.1431	0.09513	CREB3L1/MLXIP/NR1H2/MLX/TRIB3/PIK3R3/PRKAG1/RELA/SLC27A4/GSK3B/SLC27A5/FOXO1/IKBKB/SREBF1/PTPRF/MTOR/PDPK1/CPT1A/AKT1/CPT1B/INSR/RPS6KA2/G6PC3/PPP1CA/CRTC2/AKT2/PPARGC1B/SLC2A1/SLC2A2/PRKAG3/PYGB/PRKCZ/SLC2A4/NOS3/RPS6KB2/PIK3CA/PYGM/AKT3/SLC27A6/PIK3R2/GFPT2/PRKAG2/PRKCE/SLC27A1/RPS6KA3/PPP1R3E/PTPN1/PRKCB/ACACB/NR1H3	50
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	13/3122	23/8144	0.05866	0.1512	0.1005	FXYD2/SLC38A3/SLC25A10/ATP1B1/SLC9A3/ATP1A2/AQP1/ATP1A1/GLUD2/ATP1A3/CA4/GLUD1/ATP1A4	13
KEGG	hsa00562	Inositol phosphate metabolism	35/3122	73/8144	0.05881	0.1512	0.1005	ITPKB/INPPL1/PI4KB/PIK3CG/PLCB3/CDIPT/SYNJ2/PLCG2/MINPP1/PLCD3/ITPK1/PIP5KL1/PI4K2A/TPI1/INPP5K/MIOX/PI4KA/PLCB2/PIP5K1C/PIP4K2B/INPP5J/PIK3C2B/INPP5A/PIP5K1A/PIK3CA/PLCH2/PIK3C2G/INPP5E/INPP1/OCRL/IPPK/MTMR8/SACM1L/MTMR6/INPP4A	35
KEGG	hsa04975	Fat digestion and absorption	22/3122	43/8144	0.05884	0.1512	0.1005	PLA2G2D/SLC27A4/PNLIPRP2/PLA2G5/SCARB1/PLA2G12B/NPC1L1/AGPAT2/PLA2G2F/PLA2G2E/ABCG5/DGAT2/MOGAT3/ABCG8/PLA2G2A/CEL/MOGAT2/SLC27A1/APOA4/APOB/DGAT1/CLPS	22
KEGG	hsa05222	Small cell lung cancer	43/3122	92/8144	0.06055	0.1539	0.1023	TP53/ITGA2B/CDKN1A/RXRB/PIK3R3/RELA/BAK1/LAMC2/LAMA1/IKBKB/CDK2/MYC/ITGA2/AKT1/LAMB3/COL4A2/CCND1/GADD45A/ITGA3/AKT2/LAMA5/RXRA/TRAF4/COL4A1/PTGS2/TRAF2/ZBTB17/DDB2/CDK4/LAMA3/PIK3CA/TRAF6/AKT3/E2F1/PIK3R2/ITGA6/ITGAV/RXRG/BCL2/LAMC3/RB1/E2F3/PTK2	43
KEGG	hsa04979	Cholesterol metabolism	25/3122	50/8144	0.06128	0.1539	0.1023	LDLRAP1/STARD3/CYP27A1/LRPAP1/PLTP/LDLR/SCARB1/LIPG/APOC3/CYP7A1/TSPO/APOC1/LCAT/APOA2/ABCG5/APOC2/ABCG8/LRP1/PCSK9/APOA4/APOB/LPA/LIPC/APOE/OSBPL5	25
KEGG	hsa05110	Vibrio cholerae infection	25/3122	50/8144	0.06128	0.1539	0.1023	PRKACA/ATP6V1F/SLC12A2/ATP6V1G2/PLCG2/ATP6V1A/ATP6V0E1/PRKACB/KCNQ1/SEC61A1/ATP6V0C/ATP6V0A1/KDELR1/ATP6V1E1/ATP6V0E2/TCIRG1/ATP6V0D1/ADCY9/ADCY3/SEC61G/KDELR3/PRKCA/SEC61B/GNAS/ARF1	25
KEGG	hsa04914	Progesterone-mediated oocyte maturation	47/3122	102/8144	0.06578	0.1625	0.1081	PRKACA/PDE3B/SPDYA/CCNB2/PLK1/ADCY4/STK10/PIK3R3/MAD1L1/CDK2/KIF22/PRKACB/CDC25A/ADCY5/FZR1/MAP2K1/MAPK11/AKT1/PGR/RPS6KA2/CDC25C/AKT2/ADCY6/ADCY1/HSP90AA1/MAPK12/HSP90AB1/ADCY9/ANAPC1/ANAPC2/ADCY3/GNAI2/PIK3CA/AKT3/MAD2L2/ANAPC11/PIK3R2/RPS6KA3/SPDYE3/IGF1/GNAI1/ANAPC10/IGF1R/CCNA2/RAF1/PKMYT1/ARAF	47
KEGG	hsa04932	Non-alcoholic fatty liver disease	69/3122	155/8144	0.0658	0.1625	0.1081	MAP3K11/MLXIP/NDUFA13/PKLR/NDUFV1/NDUFA8/NDUFA11/MLX/NDUFA7/NDUFA6/NDUFS5/PIK3R3/PRKAG1/RELA/GSK3B/IKBKB/SREBF1/NDUFB7/IL6R/ATF4/LEPR/NDUFS7/MAPK11/CDC42/NDUFS2/AKT1/COX7A1/INSR/NDUFS3/SDHC/AKT2/LEP/NDUFS6/RXRA/CASP8/TRAF2/COX8A/NDUFA3/COX7B2/TGFB1/PRKAG3/MAPK12/MAP3K5/IL1A/NDUFC2/PIK3CA/AKT3/COX6A2/PIK3R2/PRKAG2/IL1B/NDUFA4/NDUFC1/NDUFA12/ADIPOQ/RAC1/UQCRFS1/NDUFS8/SDHB/COX5A/COX4I2/COX5B/SDHA/COX6B1/NR1H3/ITCH/ERN1/FAS/FOS	69
KEGG	hsa00531	Glycosaminoglycan degradation	11/3122	19/8144	0.06617	0.1625	0.1081	IDUA/HYAL4/HYAL2/HYAL1/NAGLU/HYAL3/SGSH/GUSB/HGSNAT/GALNS/GLB1	11
KEGG	hsa05132	Salmonella infection	107/3122	249/8144	0.0725	0.1768	0.1175	TCF7/PLEKHM2/CYFIP2/DYNC1H1/ELMO2/TLR9/KIF5A/ACTR1B/MAP2K7/KLC4/ARPC1B/STX10/MAP2K3/TUBA8/PIK3CG/CYTH2/PODXL/RAB5C/RELA/BAK1/VPS16/DNM2/IKBKB/MYL2/PLEKHM1/MYC/SNX33/DYNLRB1/KLC2/MAP2K2/TUBA3D/AHNAK2/MAP2K1/MAPK11/FHOD1/CDC42/AKT1/TLR5/RHOG/DCTN1/TRADD/TCF7L1/TXN2/NLRP3/TUBB1/AKT2/TUBB6/ROCK2/CASP8/CYFIP1/PKN1/TIRAP/ACTR3B/KLC3/PFN1/RPS3/TRAF2/PFN3/NOD1/DYNLT1/ACTR10/PIK3C2B/HSP90AA1/FLNC/KIF5B/MAPK12/HSP90AB1/RRAS/RIPK1/AHNAK/TUBA3E/TUBAL3/PIK3CA/TRAF6/FLNB/VPS18/AKT3/CASP1/PYCARD/IL1B/PIK3C2G/TCF7L2/PAK3/CYTH3/RAC1/TUBA4A/RAB9B/RAB7A/KLC1/ANXA2/FBXO22/TNFRSF10A/MAP2K4/FYCO1/TNFRSF10B/MYL7/EXOC7/ARF1/DCTN6/BCL2/ARPC5L/FOS/RAF1/MYLPF/MYO6/S100A10/RIPK3	107
KEGG	hsa04974	Protein digestion and absorption	47/3122	103/8144	0.07721	0.1866	0.1241	FXYD2/COL11A2/COL1A1/CELA3A/XPNPEP2/CTRL/SLC3A2/MEP1A/KCNQ1/SLC7A9/SLC8A2/ATP1B1/COL20A1/COL13A1/SLC9A3/COL5A1/COL6A3/COL4A2/CELA2B/COL16A1/PGA3/COL4A1/COL7A1/ATP1A2/SLC6A19/PGA5/ATP1A1/CPA2/CPA1/COL15A1/COL9A3/PRSS3/ATP1A3/SLC7A8/COL6A2/COL12A1/CTRB2/KCNN4/COL22A1/ATP1A4/COL25A1/COL27A1/COL3A1/COL9A1/KCNE3/CELA2A/COL23A1	47
KEGG	hsa04913	Ovarian steroidogenesis	25/3122	51/8144	0.07764	0.1866	0.1241	CYP11A1/PRKACA/ADCY4/LDLR/SCARB1/ALOX5/PRKACB/ADCY5/JMJD7-PLA2G4B/INSR/PTGS2/ADCY6/ADCY1/ADCY9/ACOT4/ADCY3/PLA2G4F/PLA2G4D/CYP1B1/IGF1/PLA2G4E/PLA2G4B/IGF1R/GNAS/LHB	25
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	13/3122	24/8144	0.0842	0.2009	0.1336	B4GALT7/HS6ST2/XYLT1/EXTL1/HS6ST1/NDST3/HS3ST3B1/HS3ST2/NDST1/NDST4/EXTL2/HS3ST3A1/HS3ST5	13
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	84/3122	194/8144	0.08685	0.2057	0.1368	TP53/TCF7/IRF9/SYK/CDKN1A/MAPKAPK2/MAP2K7/TICAM1/GNG3/PIK3CG/ITPR3/NFATC1/PIK3R3/TYK2/IFNA14/RELA/BAK1/GSK3B/PLCG2/IKBKB/MICA/ANGPT2/MICB/MYC/IRF7/MAP2K2/CLEC2B/MTOR/MAP2K1/HLA-G/MAPK11/SRC/VEGFA/GNG12/AKT1/CCND1/TRADD/TCF7L1/IRF3/AKT2/CALML4/CASP8/GNG5/STAT2/TLR3/PTGS2/TRAF2/IFNA13/PDGFB/NFATC2/HLA-F/PIK3R6/MAPK12/GNB4/CDK4/PIK3CA/AKT3/E2F1/LYN/CXCL3/CREBBP/PIK3R2/CALML6/PPP3CA/CALML5/CALM3/TCF7L2/CSF2/RAC1/IFNAR1/MAP1LC3A/GNB3/GNB2/ITPR1/GNG4/MAP2K4/NRAS/FAS/FOS/RAF1/RB1/GNG13/E2F3/ZFP36	84
KEGG	hsa05017	Spinocerebellar ataxia	63/3122	143/8144	0.092	0.2164	0.1439	ATXN1L/SLC25A31/KCND3/ITPR3/PLCB3/PSMB4/PIK3R3/ATP2A3/RELN/WIPI2/GRIN2D/MTOR/CACNA1A/AKT1/PSMB6/SPTBN2/ULK1/PLCB2/AKT2/PSMD8/ATP2A1/PUM2/GRIN2B/FGF14/TRAF2/PDYN/GRIN2C/KAT5/ATXN2/RYR1/MAP3K5/ADRM1/ATXN2L/PSMC6/RORA/PIK3CA/AKT3/PIK3R2/GRIN2A/ULK2/AMBRA1/PSMD7/ATXN3L/PRKCA/RBPJ/PSMA1/SLC1A6/GRIN1/NRBF2/PRKCB/PUM1/ITPR1/PSMC5/ATG2B/RBPJL/ATXN1/TBPL1/OPA1/ATXN3/ERN1/PSMD9/CIC/DAB1	63
KEGG	hsa05010	Alzheimer disease	160/3122	384/8144	0.09354	0.2176	0.1447	CSNK2B/DVL3/CSF1/APH1A/NOS1/KIF5A/SLC39A3/WNT3/MAP2K7/SLC25A31/KLC4/WNT2B/NDUFA13/NDUFV1/NDUFA8/WNT11/NDUFA11/TUBA8/NDUFA7/NDUFA6/SLC39A7/ITPR3/NDUFS5/CACNA1S/PLCB3/PSMB4/WNT16/PIK3R3/APBB1/RELA/GSK3B/IKBKB/LRP5/PSENEN/NDUFB7/ATP2A3/AXIN1/CDK5/AGER/KLC2/SLC39A5/MAP2K2/WIPI2/GRIN2D/CAPN1/MTOR/TUBA3D/FZD3/ATF4/SLC39A4/MAP2K1/NDUFS7/WNT8A/FZD2/DVL1/NDUFS2/BAD/AKT1/FZD4/FZD9/COX7A1/SLC39A13/INSR/PSMB6/ULK1/NDUFS3/PLCB2/WNT7A/SDHC/NAE1/TUBB1/AKT2/PSMD8/TUBB6/MAPT/NDUFS6/CALML4/ATP2A1/CASP8/PSEN1/GRIN2B/CHRM1/CACNA1D/WNT4/KLC3/PTGS2/TRAF2/COX8A/NOX4/NDUFA3/COX7B2/LRP6/CACNA1C/GRIN2C/WNT3A/WNT7B/SLC39A14/CSNK1A1/LRP1/KIF5B/WNT6/MAP3K5/WNT5B/ADRM1/IL1A/AXIN2/TUBA3E/PSMC6/TUBAL3/SLC39A2/NDUFC2/PIK3CA/CHRNA7/AKT3/COX6A2/PIK3R2/GRIN2A/ULK2/AMBRA1/PSMD7/CALML6/PPP3CA/IL1B/CALML5/NDUFA4/CALM3/NDUFC1/NDUFA12/WNT9A/PSMA1/UQCRFS1/SNCA/FZD5/GRIN1/CSNK1E/NRBF2/NDUFS8/APC/TUBA4A/SDHB/COX5A/COX4I2/KLC1/ITPR1/PSMC5/ATG2B/DKK2/COX5B/SDHA/COX6B1/SLC39A1/SLC39A10/NRAS/ERN1/FAS/APOE/RAF1/CACNA1F/PSMD9/ARAF	160
KEGG	hsa05170	Human immunodeficiency virus 1 infection	91/3122	212/8144	0.09381	0.2176	0.1447	APOBEC3F/AP1B1/AP1G2/MAP2K7/GNG3/CD4/PAK6/MAP2K3/LIMK1/CCNB2/ITPR3/NFATC1/PIK3R3/IFNA14/RELA/BAK1/PLCG2/IKBKB/CFL1/MAP2K2/TNFRSF1B/MTOR/MAP2K1/HLA-G/MAPK11/GNG12/BAD/AKT1/CUL1/APOBEC3D/CRKL/TRADD/CDC25C/IRF3/AKT2/CALML4/CASP8/TAPBP/GNG5/PTK2B/TRAF2/IFNA13/GNA11/NFATC2/HLA-F/MAPK12/GNB4/ATM/RIPK1/PAK2/RPS6KB2/CXCR4/PAK4/PXN/GNAI2/PIK3CA/TRAF6/AKT3/PIK3R2/CALML6/PPP3CA/PRKCA/CALML5/CALM3/CHEK1/PAK3/CRK/RAC1/GNAI1/AP1S3/TAP1/CUL5/PRKCB/RAC3/GNB3/GNB2/ITPR1/GNG4/BST2/TAP2/NRAS/BCL2/AP1M2/FAS/FOS/WEE2/RAF1/GNG13/FBXW11/PTK2/WEE1	91
KEGG	hsa05417	Lipid and atherosclerosis	92/3122	215/8144	0.09893	0.2265	0.1506	TP53/CAMK2A/MAP2K7/TICAM1/RXRB/MAP2K3/ABCG1/NFATC1/PLCB3/PIK3R3/TANK/IFNA14/RELA/GSK3B/IKBKB/VAV2/LDLR/AGER/IRF7/HSPA4/VAV1/POU2F2/ATF4/PDPK1/MAPK11/SRC/CDC42/BAD/AKT1/PLCB2/POU2F3/IRF3/NLRP3/AKT2/RXRA/CALML4/ROCK2/CASP8/MIB2/HSPA1B/CAMK2G/TIRAP/TRAF2/IFNA13/HSPA1L/NFATC2/HSPA6/HSP90AA1/NCF1/CYBA/MAPK12/MAP3K5/NOS3/HSP90AB1/PIK3CA/ARHGEF1/TRAF6/AKT3/LYN/CXCL3/PIK3R2/CCL2/CASP1/CALML6/PPP3CA/CAMK2B/PYCARD/PRKCA/IL1B/CALML5/CALM3/CD40/SOD2/RAC1/APOA4/APOB/ITPR1/CAMK2D/RAP1B/TNFRSF10A/RXRG/VAV3/MAP2K4/HSPA8/TNFRSF10B/HSPA1A/NRAS/ERN1/BCL2/FAS/FOS/PTK2	92
KEGG	hsa00591	Linoleic acid metabolism	15/3122	29/8144	0.09899	0.2265	0.1506	PLA2G2D/PLA2G5/PLA2G6/PLA2G12B/JMJD7-PLA2G4B/PLA2G2F/PLA2G2E/CYP3A4/PLA2G2A/PLA2G4F/PLA2G4D/PLA2G4E/PLA2G4B/CYP1A2/PLB1	15
KEGG	hsa04970	Salivary secretion	42/3122	93/8144	0.1055	0.2398	0.1594	NOS1/PRKACA/SLC12A2/FXYD2/ITPR3/ADCY4/PLCB3/ATP2B2/PRKACB/ADCY5/ATP1B1/SLC4A2/PLCB2/ADRA1B/DMBT1/CALML4/ATP2B4/BEST2/ATP1A2/ATP1A1/ADCY6/ADCY1/ATP1A3/ADCY9/ADCY3/TRPV6/CD38/AQP5/KCNN4/SLC9A1/ATP1A4/CALML6/PRKCA/CALML5/CALM3/PRKCB/ITPR1/GNAS/AMY2B/CST1/KCNMA1/CAMP	42
KEGG	hsa05160	Hepatitis C	68/3122	157/8144	0.1132	0.2554	0.1698	TP53/IRF9/CDKN1A/PPP2R1B/TICAM1/CLDN5/PIK3R3/TYK2/IFNA14/RELA/BAK1/EGFR/GSK3B/IKBKB/CDK2/LDLR/SCARB1/MYC/IRF7/SOS2/MAP2K2/CLDN7/MAP2K1/BAD/AKT1/CD81/OCLN/PPP2R2C/CCND1/TRADD/IRF3/PSME3/AKT2/RXRA/CASP8/STAT2/TLR3/TRAF2/IFNA13/EIF2AK1/RIPK1/CLDN14/CDK4/CLDN10/PPP2R1A/PIK3CA/TRAF6/AKT3/E2F1/PIK3R2/OAS1/MX1/CLDN6/YWHAG/IFNAR1/CLDN19/CLDN18/PPP2R2A/NRAS/NR1H3/EGF/FAS/RAF1/YWHAE/RB1/E2F3/MX2/ARAF	68
KEGG	hsa04976	Bile secretion	40/3122	89/8144	0.1196	0.268	0.1782	PRKACA/FXYD2/ADCY4/SLC27A5/LDLR/SCARB1/PRKACB/ADCY5/CYP7A1/ATP1B1/SLC4A2/SLC9A3/NR0B2/EPHX1/ABCG5/CYP3A4/RXRA/SLC2A1/SLC22A8/SLC22A1/ATP1A2/AQP1/ABCG8/ATP1A1/ADCY6/ADCY1/SCTR/ATP1A3/ADCY9/UGT2B15/ADCY3/SLC9A1/ATP1A4/UGT1A1/UGT2A1/UGT2B17/GNAS/UGT2A3/HMGCR/ABCB1	40
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/3122	14/8144	0.1213	0.27	0.1796	ST3GAL2/ST3GAL1/ST3GAL3/B3GNT7/CHST1/B4GALT2/CHST6/B3GNT2	8
KEGG	hsa04114	Oocyte meiosis	57/3122	131/8144	0.1279	0.283	0.1882	ESPL1/PPP2R5D/PRKACA/PPP2R5A/PPP2R1B/CAMK2A/SPDYA/CCNB2/ITPR3/PLK1/ADCY4/MAD1L1/CDK2/PRKACB/ADCY5/MAP2K1/MAPK11/SMC1A/PGR/CUL1/RPS6KA2/CDC25C/PPP1CA/CALML4/FBXO43/CDC20/CAMK2G/ADCY6/ADCY1/MAPK12/PPP2R5B/ADCY9/ANAPC1/ANAPC2/ADCY3/PPP2R1A/MAD2L2/ANAPC11/AR/CALML6/PPP3CA/CAMK2B/CALML5/CALM3/REC8/RPS6KA3/SPDYE3/YWHAG/IGF1/ANAPC10/ITPR1/CAMK2D/IGF1R/STAG3/YWHAE/FBXW11/PKMYT1	57
KEGG	hsa04918	Thyroid hormone synthesis	34/3122	75/8144	0.129	0.2835	0.1885	CREB3L1/GPX2/TG/GPX1/PRKACA/ATF6B/FXYD2/ITPR3/ADCY4/PLCB3/GPX3/ASGR1/PRKACB/ADCY5/ATF4/ATP1B1/PLCB2/ATP1A2/TPO/ATP1A1/ADCY6/ADCY1/ATP1A3/ADCY9/ADCY3/DUOX2/ATP1A4/PRKCA/ASGR2/PRKCB/ITPR1/GNAS/DUOX1/PAX8	34
KEGG	hsa04070	Phosphatidylinositol signaling system	43/3122	97/8144	0.1324	0.2891	0.1922	ITPKB/INPPL1/PI4KB/ITPR3/PLCB3/PIK3R3/CDIPT/SYNJ2/PLCG2/IP6K3/PLCD3/DGKD/ITPK1/PI4K2A/PI4KA/PLCB2/PIP5K1C/CALML4/PIP4K2B/IP6K2/PIK3C2B/INPP5A/DGKB/DGKZ/PIP5K1A/PIK3CA/PIK3R2/CALML6/PRKCA/CALML5/PIK3C2G/CALM3/INPP5E/INPP1/OCRL/IPPK/CDS2/PRKCB/ITPR1/MTMR8/SACM1L/MTMR6/INPP4A	43
KEGG	hsa04922	Glucagon signaling pathway	47/3122	107/8144	0.1366	0.2962	0.197	CREB3L1/PRKACA/PDE3B/SIK1/CAMK2A/PHKG1/ITPR3/PLCB3/PRKAG1/FBP1/FOXO1/GCK/PFKL/PRKACB/ATF4/CPT1A/AKT1/CPT1B/G6PC3/PLCB2/CRTC2/AKT2/CALML4/SLC2A1/LDHB/CAMK2G/PPP4C/SLC2A2/PRKAG3/PYGB/PRMT1/PFKP/PYGM/AKT3/CREBBP/CPT1C/CALML6/PRKAG2/PPP3CA/CAMK2B/CALML5/CALM3/FBP2/ITPR1/CAMK2D/GNAS/ACACB	47
KEGG	hsa04115	p53 signaling pathway	33/3122	73/8144	0.1377	0.2968	0.1974	CHEK2/TP53/CDKN1A/SESN2/SERPINE1/CCNB2/PPM1D/TSC2/CDK2/MDM2/CD82/BBC3/CCND1/GADD45A/SHISA5/CASP8/TP73/SESN3/SESN1/DDB2/ATM/CDK4/CCND2/AIFM2/PMAIP1/TP53I3/CHEK1/TP53AIP1/IGF1/TNFRSF10A/TNFRSF10B/BCL2/FAS	33
KEGG	hsa00561	Glycerolipid metabolism	28/3122	61/8144	0.1386	0.2968	0.1974	GLYCTK/AKR1A1/PNLIPRP2/AKR1B1/ALDH9A1/DGKD/LIPG/MBOAT2/AGPAT2/AGPAT4/PNPLA2/MGLL/DGAT2/MOGAT3/DGKB/MOGAT1/CEL/DGKZ/MOGAT2/AKR1B10/PNPLA3/LPIN1/ALDH1B1/MBOAT1/AGK/AGPAT3/LIPC/DGAT1	28
KEGG	hsa04142	Lysosome	57/3122	132/8144	0.1437	0.3058	0.2033	NEU1/TPP1/AP1B1/AP1G2/CTNS/WDR7/PLA2G15/ABCB9/MAN2B1/CLTB/LAPTM5/IDUA/HYAL4/HYAL2/ASAH1/ABCA2/CTSS/HYAL1/CTSB/DNASE2/NAGLU/HYAL3/PPT2/ARSG/PSAP/GBA/CTSD/SGSH/ATP6V0C/ATP6V0A1/IGF2R/NAGPA/AP3M1/TCIRG1/AP3B2/ATP6V0D1/AP3D1/GAA/DMXL1/AP3B1/FUCA2/LITAF/AP3S1/CTSK/GUSB/CTSA/HGSNAT/AP1S3/NCOA7/DNASE2B/ACP2/CLN3/GNPTG/GGA2/AP1M2/GALNS/GLB1	57
KEGG	hsa05033	Nicotine addiction	19/3122	40/8144	0.1511	0.3194	0.2124	CHRNA4/GABRB3/GABRA5/GRIN2D/CACNA1A/GABRB2/GRIN2B/GABRG3/CACNA1B/GRIN2C/GABRA3/GABRR2/CHRNA7/GRIN2A/CHRNB2/GABRE/GRIN1/GABRP/GABRD	19
KEGG	hsa04950	Maturity onset diabetes of the young	13/3122	26/8144	0.1531	0.3217	0.2139	PKLR/GCK/HNF1B/NR5A2/SLC2A2/HNF4G/BHLHA15/FOXA3/PAX4/HNF4A/HES1/RFX6/HHEX	13
KEGG	hsa00230	Purine metabolism	55/3122	128/8144	0.1598	0.3335	0.2218	PDE4C/PDE2A/PDE3B/PDE9A/NT5C1A/ADCY4/AK1/AK7/PFAS/GUCY2D/ENTPD2/ADK/NPR1/ENTPD6/NUDT9/PDE6A/ADCY5/NME2/AMPD2/CANT1/GUK1/PDE6B/NT5M/ADCY10/NT5E/NUDT2/PDE1B/ENPP4/PDE3A/ADCY6/ADCY1/PNP/NUDT16/PDE4A/ADCY9/ENTPD5/AK5/ADCY3/NME1-NME2/PDE5A/ITPA/ENTPD8/NUDT5/GMPR/NPR2/PDE4B/NME7/PDE1C/DGUOK/ALLC/NME4/PDE10A/ADSL/PAPSS2/GMPR2	55
KEGG	hsa05016	Huntington disease	126/3122	306/8144	0.163	0.3381	0.2248	TP53/SLC1A3/AP2M1/CREB3L1/GPX2/GPX1/KIF5A/ACTR1B/MAP2K7/SLC25A31/KLC4/POLR2A/CLTB/NDUFA13/NDUFV1/NDUFA8/NDUFA11/HTT/TUBA8/NDUFA7/POLR2E/NDUFA6/NDUFS5/PLCB3/PSMB4/DNAI2/TAF4B/DNAH14/GPX3/DNAI1/NDUFB7/STX1A/HIP1/KLC2/WIPI2/MTOR/TUBA3D/AP2A2/POLR2F/POLR2J/NDUFS7/NDUFS2/DNAH17/COX7A1/AP2S1/PSMB6/DNAH2/ULK1/DCTN1/BBC3/NDUFS3/PLCB2/SDHC/MAP3K10/HAP1/TUBB1/DNAH1/PSMD8/TUBB6/NDUFS6/BDNF/CASP8/RCOR1/GRIN2B/SLC1A2/KCNJ10/KLC3/DNAH10/TRAF2/CACNA1B/COX8A/POLR2C/NDUFA3/COX7B2/ACTR10/DNAL4/KIF5B/MAP3K5/ADRM1/DNAH11/TAF4/POLR2B/TUBA3E/PSMC6/TUBAL3/NDUFC2/COX6A2/CREBBP/DNAH3/UCP1/ULK2/NRF1/AMBRA1/PSMD7/DNALI1/NDUFA4/NDUFC1/NDUFA12/SOD2/PSMA1/UQCRFS1/GRIN1/NRBF2/POLR2J2/NDUFS8/TUBA4A/SDHB/COX5A/COX4I2/KLC1/ITPR1/PSMC5/TGM2/ATG2B/COX5B/AP2A1/POLR2L/TBPL1/SDHA/COX6B1/ERN1/AP2B1/DCTN6/REST/DLG4/PSMD9	126
KEGG	hsa00410	beta-Alanine metabolism	15/3122	31/8144	0.1662	0.3412	0.2269	ALDH3B1/ACADS/ECHS1/CNDP1/ACOX3/ALDH9A1/ALDH3A1/AOC3/CSAD/AOC2/SMOX/ALDH3B2/ACOX1/ALDH1B1/UPB1	15
KEGG	hsa04977	Vitamin digestion and absorption	12/3122	24/8144	0.1665	0.3412	0.2269	SLC46A1/ABCC1/SCARB1/FOLH1/SLC5A6/SLC23A1/SLC19A3/MMACHC/TCN2/APOA4/APOB/PLB1	12
KEGG	hsa04350	TGF-beta signaling pathway	41/3122	94/8144	0.1702	0.3466	0.2305	CHRD/SMAD3/BMPR2/BMP8A/PPP2R1B/ACVR2B/GDF5/RGMA/AMHR2/LEFTY1/LEFTY2/MYC/BMP8B/CUL1/HAMP/GDF7/AMH/SMAD6/TGFBR2/TGFB1/FST/SMAD7/SMURF1/BMPR1B/ACVR2A/RPS6KB2/SMAD1/PPP2R1A/BMP4/E2F4/CREBBP/ID3/BMP2/GREM1/E2F5/RBL1/BMP7/GREM2/ZFYVE9/FMOD/TGIF1	41
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/3122	15/8144	0.1755	0.3536	0.2351	ST3GAL2/ST3GAL1/B4GALNT1/ST8SIA5/ST6GALNAC4/ST3GAL5/ST6GALNAC6/GLB1	8
KEGG	hsa04670	Leukocyte transendothelial migration	49/3122	114/8144	0.1757	0.3536	0.2351	ACTN4/CLDN5/PIK3R3/MMP2/PLCG2/BCAR1/MYL2/VAV2/THY1/VAV1/CLDN7/MAPK11/CDC42/OCLN/ACTN1/JAM3/ROCK2/PTK2B/JAM2/VASP/ESAM/CTNNA2/NCF1/CYBA/ITGAL/MAPK12/CLDN14/CXCR4/PXN/CDH5/CLDN10/GNAI2/PIK3CA/PIK3R2/PRKCA/SIPA1/CLDN6/RAC1/GNAI1/CLDN19/PRKCB/RAP1B/CLDN18/CTNNA1/VAV3/MYL7/RAPGEF4/PTK2/MYLPF	49
KEGG	hsa04392	Hippo signaling pathway - multiple species	14/3122	29/8144	0.1804	0.3607	0.2399	DCHS1/LATS1/TEAD3/RASSF1/SAV1/TEAD4/WWC1/RASSF4/WWTR1/FRMD1/LATS2/FAT4/CSNK1E/LIMD1	14
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	92/3122	222/8144	0.1851	0.3679	0.2447	CHEK2/TP53/ESPL1/LCK/SMAD3/CREB3L1/CDKN1A/PRKACA/SLC25A31/TCF3/CD4/JAK3/ATF6B/CCNB2/ADCY4/NFATC1/PIK3R3/TLN1/RELA/KAT2A/MAD1L1/RELB/IKBKB/CDK2/MYC/TRRAP/MAP2K2/PRKACB/ADCY5/ATF4/MAP2K1/HLA-G/AKT1/TSPO/FDPS/CCND1/MAP3K1/NFYB/CRTC2/AKT2/IL2/SPI1/SLC2A1/CDC20/VAC14/TGFBR2/KAT5/ADCY6/TGFB1/NFATC2/ADCY1/HLA-F/ITGAL/MSX2/ATM/ADCY9/ANAPC1/ANAPC2/CDK4/ADCY3/CCND2/PIK3CA/RANBP1/CRTC1/TERT/XPO1/AKT3/E2F1/ANAPC11/CREBBP/PIK3R2/GPS2/PPP3CA/CHEK1/CD40/CSF2/ELK4/ANAPC10/TLN2/TNFRSF13C/TBPL1/ELK1/MAP2K4/MAP3K14/NRAS/CCNA2/FOS/MMP7/LTBR/RB1/E2F3/ZFP36	92
KEGG	hsa03020	RNA polymerase	16/3122	34/8144	0.1909	0.3772	0.2509	POLR1A/POLR3E/POLR2A/POLR3GL/POLR2E/POLR1D/POLR2F/POLR2J/POLR3B/POLR3H/POLR2C/POLR3G/POLR2B/CD3EAP/POLR2J2/POLR2L	16
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	43/3122	100/8144	0.1938	0.3808	0.2532	SMAD3/VEGFB/SERPINE1/NFATC1/PLCB3/PIK3R3/RELA/MMP2/PLCG2/FOXO1/COL1A1/AGER/PLCD3/MAPK11/VEGFA/CDC42/AKT1/COL4A2/PLCB2/CCND1/AKT2/COL4A1/TGFBR2/NOX4/TGFB1/VEGFC/PRKCZ/MAPK12/NOS3/IL1A/CDK4/PIK3CA/AKT3/PIK3R2/CCL2/PRKCE/PRKCA/IL1B/RAC1/COL3A1/PRKCB/NRAS/BCL2	43
KEGG	hsa04962	Vasopressin-regulated water reabsorption	20/3122	44/8144	0.2055	0.4014	0.2669	CREB3L1/DYNC1H1/PRKACA/AQP2/ARHGDIG/RAB5C/PRKACB/AQP3/RAB11A/DCTN1/AVPR2/ADCY6/ADCY9/NSF/ADCY3/AVP/STX4/GNAS/RAB11B/DCTN6	20
KEGG	hsa04136	Autophagy - other	15/3122	32/8144	0.2068	0.4015	0.267	ATG4D/ATG4B/ATG9B/WIPI2/MTOR/RPTOR/ATG9A/MLST8/ATG12/GABARAP/ULK2/ATG5/ATG2B/ATG16L1/GABARAPL1	15
KEGG	hsa04520	Adherens junction	31/3122	71/8144	0.2096	0.4047	0.2691	ACTN4/CSNK2B/TCF7/SMAD3/ERBB2/EGFR/PTPRF/SNAI1/PTPRJ/SRC/CDC42/INSR/TCF7L1/ACTN1/TGFBR2/CTNNA2/FGFR1/CREBBP/PTPRB/TCF7L2/NLK/PTPRM/PTPN1/SORBS1/RAC1/FER/RAC3/BAIAP2/IGF1R/CTNNA1/PARD3	31
KEGG	hsa04140	Autophagy - animal	59/3122	141/8144	0.2178	0.4181	0.278	BNIP3/PRKACA/SQSTM1/AKT1S1/DAPK3/PIK3R3/TANK/STK11/DAPK2/TSC2/TSC1/ATG4D/CTSB/ATG4B/ATG9B/MAP2K2/WIPI2/PRKACB/MTOR/MAP2K1/PDPK1/CAMKK2/BAD/AKT1/CTSD/ULK1/AKT2/RPTOR/ATG9A/MLST8/MRAS/RRAGD/UVRAG/RRAS/ATG12/RPS6KB2/RHEB/PIK3CA/TRAF6/AKT3/GABARAP/DAPK1/PIK3R2/ULK2/AMBRA1/RRAGA/ATG5/MAP1LC3A/NRBF2/RAB7A/ITPR1/ATG2B/IGF1R/NRAS/ERN1/ATG16L1/BCL2/RAF1/GABARAPL1	59
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	38/3122	89/8144	0.2282	0.435	0.2893	CSNK2B/LCK/TLR9/TICAM1/CD4/MAP2K3/ZAP70/NFATC1/PIK3R3/RELA/EGFR/IKBKB/MAP2K2/MTOR/MAP2K1/MAPK11/AKT1/AKT2/TIRAP/RASGRP1/NFATC2/BATF2/MAPK12/CD28/RPS6KB2/PIK3CA/TRAF6/AKT3/PIK3R2/PDCD1/PPP3CA/NFKBIB/NRAS/EGF/FOS/RAF1/BATF3/NFKBIE	38
KEGG	hsa04640	Hematopoietic cell lineage	42/3122	99/8144	0.2292	0.435	0.2893	CSF1/ITGA2B/CD4/FLT3LG/CD8B/CD7/CD59/IL11RA/ANPEP/IL6R/CD22/ITGA2/GP1BB/CSF3R/ITGB3/ITGA3/CR2/IL4R/THPO/GP1BA/CD37/CR1L/CD9/IL1A/CD8A/CD38/CD44/CD1A/CD1D/IL1B/FLT3/CSF2/ITGA6/GP9/KITLG/CSF1R/IL4/IL3/CD19/IL11/FCER2/CD1B	42
KEGG	hsa01212	Fatty acid metabolism	25/3122	57/8144	0.2331	0.4398	0.2925	ACADS/FADS2/ECHS1/ACADVL/ACOX3/ACSL6/PPT2/CPT1A/CPT1B/ACSBG1/FADS1/MECR/ELOVL1/ACSF3/ACAA2/FASN/SCD5/SCP2/CPT1C/HSD17B12/TECR/ACSBG2/ACOX1/MCAT/HSD17B4	25
KEGG	hsa00360	Phenylalanine metabolism	8/3122	16/8144	0.2383	0.4471	0.2973	ALDH3B1/HPD/ALDH3A1/AOC3/AOC2/IL4I1/ALDH3B2/MAOB	8
KEGG	hsa05142	Chagas disease	43/3122	102/8144	0.2419	0.4506	0.2997	TLR9/PPP2R1B/TICAM1/SERPINE1/PLCB3/PIK3R3/RELA/IKBKB/MAPK11/GNAL/AKT1/C1QA/PPP2R2C/PLCB2/AKT2/IL2/CASP8/C1QC/GNA11/TGFBR2/GNA15/TGFB1/ADCY1/IL10/MAPK12/GNA14/BDKRB2/C1QB/PPP2R1A/GNAI2/PIK3CA/TRAF6/AKT3/PIK3R2/CCL2/IL1B/ACE/GNAI1/GNAS/MAP2K4/PPP2R2A/FAS/FOS	43
KEGG	hsa02010	ABC transporters	20/3122	45/8144	0.2429	0.4506	0.2997	ABCG4/ABCB9/ABCG1/ABCC1/ABCA2/ABCB8/ABCC8/ABCA3/ABCA9/ABCG5/DEFB1/ABCG8/ABCA5/ABCC11/TAP1/ABCC10/ABCA7/ABCA6/TAP2/ABCB1	20
KEGG	hsa04380	Osteoclast differentiation	53/3122	128/8144	0.2635	0.4862	0.3233	LCK/IRF9/CSF1/SYK/SQSTM1/MAP2K7/NFATC1/PIK3R3/TYK2/RELA/PLCG2/RELB/IKBKB/LILRA1/MAP2K1/MAPK11/LILRB2/AKT1/TYROBP/ITGB3/LILRB5/AKT2/SPI1/STAT2/TRAF2/TGFBR2/TGFB1/NFATC2/NCF1/CYBA/MAPK12/LILRB4/IL1A/PIK3CA/TRAF6/AKT3/PIK3R2/SIRPA/PPP3CA/IL1B/CTSK/RAC1/IFNAR1/CAMK4/BTK/CALCR/LCP2/BLNK/MAP3K14/CSF1R/FOS/FOSL2/FCGR3A	53
KEGG	hsa01524	Platinum drug resistance	31/3122	73/8144	0.2697	0.495	0.3291	TP53/CDKN1A/GSTM4/ERBB2/PIK3R3/BAK1/GSTT2/BIRC5/MDM2/TOP2A/PDPK1/BAD/AKT1/GSTT2B/BBC3/AKT2/CASP8/GSTM3/MAP3K5/ATM/ERCC1/PIK3CA/AKT3/PIK3R2/PMAIP1/GSTO1/MSH6/GSTA5/MLH1/BCL2/FAS	31
KEGG	hsa04710	Circadian rhythm	14/3122	31/8144	0.2721	0.4966	0.3303	NPAS2/CSNK1D/PRKAG1/PER2/PER1/CUL1/ARNTL/PRKAG3/NR1D1/RORA/RORC/PRKAG2/CSNK1E/FBXW11	14
KEGG	hsa04514	Cell adhesion molecules	61/3122	149/8144	0.2813	0.5106	0.3395	CD276/ITGB7/CLDN5/CD4/LRRC4B/CNTN2/CD8B/CNTNAP1/NCAM1/NTNG2/PTPRF/MAG/CD22/NRXN2/CADM3/CLDN7/CDH4/CDH3/LRRC4C/ITGA9/HLA-G/ICAM3/OCLN/MPZL1/JAM3/CD6/JAM2/ESAM/NFASC/HLA-F/L1CAM/CDH15/ITGAL/CNTNAP2/CD28/CLDN14/CD8A/CDH5/CLDN10/NLGN2/PDCD1/NRXN3/VCAN/CD40/PTPRM/CLDN6/ITGA6/CD58/SDC3/LRRC4/NTNG1/CLDN19/NRCAM/SDC4/ITGAV/CLDN18/VTCN1/NLGN1/SIGLEC1/NRXN1/NEGR1	61
KEGG	hsa05206	MicroRNAs in cancer	124/3122	310/8144	0.2884	0.5207	0.3462	TP53/MAPK7/CDKN1A/BMPR2/WNT3/MIR106B/SHC4/MIR1-1/EFNA1/NOTCH3/NOTCH1/ERBB2/DNMT3A/MIR25/MIR181C/PIK3R3/MIR181A1/BAK1/HDAC5/ABCC1/EGFR/MIR326/ABL1/PLCG2/MIR150/IKBKB/MIR135A1/EFNA3/MIR324/MIR181D/MYC/HNRNPK/MDM2/UBE2I/RASSF1/MIR181B1/MARCKS/SOS2/MAP2K2/MIR129-1/CDC25A/MTOR/FZD3/DNMT3B/MAP2K1/SHC1/VEGFA/MIR200C/TNR/ITGB3/CCND1/CRKL/CDC25C/PDGFRA/MIR183/HDAC4/MIR199A1/RPTOR/SLC7A1/TNXB/PTGS2/PDGFB/ST14/TNC/VIM/MIR141/SLC45A3/WNT3A/EFNA2/TRIM71/MIR126/HMGA2/MIR143/FGFR3/MIR199A2/ATM/DNMT1/MIR195/PAK4/CCND2/PIK3CA/MIR200B/MIR96/CD44/MIR34A/MIR194-2/E2F1/CREBBP/PIK3R2/MIRLET7C/CYP1B1/PRKCE/PRKCA/MIR107/PDGFA/ERBB3/NOTCH4/CRK/PDGFRB/ZEB2/SPRY2/APC/PRKCB/MIR205/MIR206/TPM1/HMOX1/MIR26B/MIRLET7A1/FOXP1/MIR133A2/NRAS/ZFPM2/MIR155/BCL2/ABCB1/MIR200A/RAF1/MIR128-2/E2F3/MIR194-1/MIR215/MIR520A/MIR16-1	124
KEGG	hsa04936	Alcoholic liver disease	58/3122	142/8144	0.2953	0.5302	0.3526	TCF7/ACADVL/ACOX3/MAP2K7/TICAM1/MAP2K3/PRKAG1/IFNA14/RELA/GSK3B/FOXO1/IKBKB/SREBF1/ALDH9A1/TRA2A/MAPK11/CPT1A/CAMKK2/AKT1/C1QA/CPT1B/CCND1/TRADD/TCF7L1/IRF3/AKT2/CASP8/C1QC/TIRAP/IFNA13/NOX4/PRKAG3/MAPK12/MAP3K5/RIPK1/C1QB/FASN/TRAF6/AKT3/CXCL3/SCD5/CPT1C/PRKAG2/ADH5/IL1B/C2/TCF7L2/C4A/C4B/ADIPOQ/LPIN1/ACOX1/ALDH1B1/ACACB/MAP2K4/MAP3K14/TRA2B/FAS	58
KEGG	hsa05202	Transcriptional misregulation in cancer	78/3122	193/8144	0.2979	0.5322	0.3539	TP53/ITGB7/NTRK1/CDKN1A/JUP/MEN1/RXRB/TCF3/CDK9/WNT16/RELA/BAK1/LYL1/FOXO1/PER2/RARA/MYC/ZBTB16/DOT1L/MDM2/NCOR1/ETV6/FLI1/PTCRA/PROM1/ASPSCR1/SS18/GADD45A/PLAT/RXRA/SPI1/SS18L1/BAIAP3/FLT1/KDM6A/ARNT2/TGFBR2/MLF1/ZBTB17/MLLT3/SLC45A3/DDB2/RUNX2/HMGA2/ETV1/ATM/SMAD1/BCL11B/CCND2/PAX5/NFKBIZ/ERG/AFF1/PDGFA/FLT3/PML/CD40/CSF2/NUPR1/LDB1/IGF1/ELK4/BMP2K/DEFA4/IGF1R/DDX5/RXRG/TAF15/CSF1R/IL3/CCNA2/ETV5/SPINT1/HHEX/PTK2/NGFR/MLLT1/PAX8	78
KEGG	hsa00910	Nitrogen metabolism	8/3122	17/8144	0.3071	0.5456	0.3628	CA9/CA12/CA6/CA5A/GLUD2/CA4/GLUD1/CA3	8
KEGG	hsa05146	Amoebiasis	42/3122	102/8144	0.3096	0.547	0.3638	ACTN4/PRKACA/PRDX1/PLCB3/PIK3R3/RAB5C/RELA/LAMC2/LAMA1/COL1A1/PRKACB/GNAL/LAMB3/COL4A2/PLCB2/ACTN1/LAMA5/COL4A1/GNA11/GNA15/HSPB1/TGFB1/ADCY1/IL10/GNA14/LAMA3/PIK3CA/CXCL3/PIK3R2/CD1A/CD1D/PRKCA/IL1B/CSF2/COL3A1/PRKCB/RAB7A/GNAS/MUC2/LAMC3/PTK2/CD1B	42
KEGG	hsa05100	Bacterial invasion of epithelial cells	32/3122	77/8144	0.3179	0.5553	0.3692	ELMO2/SHC4/CLTB/ARPC1B/SHC2/PIK3R3/BCAR1/DNM2/SHC3/SHC1/SRC/CDC42/RHOG/DNM1/CRKL/CTTN/DOCK1/ELMO3/ACTR3B/CAV3/CTNNA2/DNM3/PXN/PIK3CA/MAD2L2/PIK3R2/CRK/RAC1/CBL/CTNNA1/ARPC5L/PTK2	32
KEGG	hsa01200	Carbon metabolism	47/3122	115/8144	0.3185	0.5553	0.3692	HK2/ACADS/ALDOC/ECHS1/ALDOA/ACOX3/GLYCTK/PKLR/GPT2/FBP1/GCK/ENO3/PFKL/HK3/TPI1/SHMT1/TKT/AMT/HKDC1/HK1/SDHC/IDH2/GPT/GPI/SDSL/PC/ACO2/ME1/GLUD2/DLST/PFKP/PCCB/GLUD1/PHGDH/H6PD/IDH3A/ME3/ACSS1/ADH5/DLD/ACOX1/FBP2/SDHB/PSPH/SDHA/PGP/ENO2	47
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	12/3122	27/8144	0.3203	0.5553	0.3692	FADS2/ACOX3/ACOT7/FADS1/ELOVL1/ACOT4/SCD5/SCP2/HSD17B12/TECR/ACOX1/HSD17B4	12
KEGG	hsa00010	Glycolysis / Gluconeogenesis	28/3122	67/8144	0.3209	0.5553	0.3692	HK2/ALDH3B1/ALDOC/ALDOA/PKLR/AKR1A1/FBP1/GCK/ALDH9A1/MINPP1/ENO3/PFKL/ALDH3A1/HK3/TPI1/HKDC1/G6PC3/HK1/GPI/LDHB/PFKP/ACSS1/ADH5/ALDH3B2/DLD/FBP2/ALDH1B1/ENO2	28
KEGG	hsa00514	Other types of O-glycan biosynthesis	20/3122	47/8144	0.3246	0.5571	0.3704	RFNG/PLOD3/GALNT9/GALNT14/LFNG/GALNT6/GALNT2/POMT1/ST3GAL3/POMT2/POFUT2/GALNT7/ST6GAL1/B4GALT2/GALNTL6/ST6GAL2/GALNT11/GALNT13/GALNT10/GALNT5	20
KEGG	hsa05169	Epstein-Barr virus infection	81/3122	202/8144	0.3252	0.5571	0.3704	TP53/IRF9/SYK/CDKN1A/MAP2K7/NCOR2/JAK3/MAP2K3/PIK3R3/TYK2/IFNA14/RELA/BAK1/PLCG2/RELB/IKBKB/CDK2/MYC/IRF7/MDM2/HLA-G/MAPK11/AKT1/CCND1/GADD45A/TRADD/IRF3/AKT2/PSMD8/CASP8/CR2/TAPBP/STAT2/TRAF2/IFNA13/VIM/HLA-F/DDB2/ITGAL/MAPK12/ADRM1/ISG15/RIPK1/PSMC6/CDK4/CCND2/PIK3CA/TRAF6/CD44/AKT3/E2F1/LYN/PIK3R2/OAS1/PSMD7/RBPJ/CD40/ENTPD8/CD58/RAC1/IFNAR1/USP7/BTK/HES1/TAP1/NFKBIB/PSMC5/RBPJL/MAP2K4/TAP2/BLNK/RUNX3/MAP3K14/CD19/CCNA2/BCL2/FAS/FCER2/RB1/E2F3/NFKBIE	81
KEGG	hsa05130	Pathogenic Escherichia coli infection	79/3122	197/8144	0.3277	0.5584	0.3713	CYFIP2/CLDN5/ARPC1B/MYO1C/TUBA8/NCK1/CYTH2/SEC24C/RELA/BAK1/ABL1/IKBKB/MYH9/CLDN7/TUBA3D/MAPK11/SRC/CDC42/TLR5/OCLN/TRADD/CTTN/LPAR5/NLRP3/TUBB1/SEC24A/TUBB6/ROCK2/CASP8/CYFIP1/TIRAP/LPAR2/MYO1F/ACTR3B/WIPF3/RPS3/TRAF2/MYO1A/F2/MAPK12/NCK2/RIPK1/PAK2/CLDN14/TUBA3E/TUBAL3/CLDN10/MYH14/ARHGEF1/TRAF6/MYH10/CASP1/PYCARD/IL1B/CLDN6/PAK3/CYTH3/LPAR1/RAC1/CLDN19/TUBA4A/BAIAP2/ARHGEF2/NFKBIB/CLDN18/TNFRSF10A/MYO5C/TNFRSF10B/MYO1E/MYO10/ARF1/ARPC5L/MYO1D/BAIAP2L1/SEC24D/FAS/FOS/MYO6/ARHGEF12	79
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	89/3122	223/8144	0.3355	0.5687	0.3782	SLC26A6/PRKD2/MAP2K7/SLC25A31/GSTM4/NDUFA13/NDUFV1/NDUFA8/AKR1C4/NDUFA11/NDUFA7/NDUFA6/NDUFS5/PIK3R3/AKR1A1/RELA/GSTT2/EGFR/ABL1/IKBKB/NDUFB7/SLC26A9/SOS2/MAP2K2/PTPRJ/MAP2K1/PDPK1/NDUFS7/MAPK11/SRC/VEGFA/NDUFS2/BAD/AKT1/GSTT2B/COX7A1/SLC26A1/EPHX3/NDUFS3/SDHC/EPHX1/AKT2/NDUFS6/COX8A/GSTM3/NOX4/NDUFA3/COX7B2/NCF1/KEAP1/CYBA/MAPK12/MAP3K5/NDUFC2/PIK3CA/CYP2F1/AKT3/COX6A2/PIK3R2/PRKD1/GSTO1/CYP1B1/NDUFA4/NDUFC1/NDUFA12/SOD2/PTPN1/RAC1/UQCRFS1/NDUFS8/SDHB/COX5A/HMOX1/COX4I2/COX5B/GSTA5/MAP2K4/SDHA/COX6B1/MAP3K14/CYP1A2/NRAS/EGF/FOS/RAF1/NQO1/PTK2/PLD1/ARAF	89
KEGG	hsa00730	Thiamine metabolism	7/3122	15/8144	0.3393	0.5724	0.3806	AK1/AK7/THTPA/NFS1/ALPP/AK5/ALPL	7
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/3122	20/8144	0.3454	0.5777	0.3842	CHPF2/CHST3/B4GALT7/XYLT1/CHST11/CHST13/CHPF/CHST15/CHST14	9
KEGG	hsa05161	Hepatitis B	65/3122	162/8144	0.3459	0.5777	0.3842	TP53/SMAD3/CREB3L1/CDKN1A/MAP2K7/TICAM1/STAT6/JAK3/MAP2K3/ATF6B/NFATC1/PIK3R3/TYK2/IFNA14/RELA/IKBKB/BIRC5/CDK2/MYC/IRF7/SOS2/MAP2K2/ATF4/MAP2K1/MAPK11/SRC/BAD/AKT1/CASP10/MAP3K1/IRF3/AKT2/CASP8/STAT2/TIRAP/TLR3/PTK2B/IFNA13/TGFBR2/TGFB1/NFATC2/DDB2/MAPK12/PIK3CA/TRAF6/AKT3/E2F1/CREBBP/PIK3R2/PRKCA/HSPG2/IFNAR1/PRKCB/IFIH1/ELK1/MAP2K4/NRAS/CCNA2/BCL2/FAS/FOS/RAF1/RB1/E2F3/ARAF	65
KEGG	hsa03410	Base excision repair	14/3122	33/8144	0.3757	0.6201	0.4124	POLL/OGG1/NEIL1/LIG3/POLE/NEIL2/POLD4/POLD1/MUTYH/POLD2/NTHL1/FEN1/APEX2/SMUG1	14
KEGG	hsa03450	Non-homologous end-joining	6/3122	13/8144	0.3768	0.6201	0.4124	POLL/LIG4/XRCC4/POLM/FEN1/DCLRE1C	6
KEGG	hsa04668	TNF signaling pathway	45/3122	112/8144	0.3772	0.6201	0.4124	CSF1/CREB3L1/BCL3/MAP2K7/MAP2K3/LIF/ATF6B/DAB2IP/PIK3R3/NOD2/RELA/IKBKB/RPS6KA4/TNFRSF1B/ATF4/MAP2K1/MAPK11/AKT1/CASP10/TRADD/AKT2/MMP14/CASP8/PGAM5/PTGS2/TRAF2/VEGFC/MAPK12/MAP3K5/CX3CL1/RIPK1/PIK3CA/AKT3/CXCL3/PIK3R2/CCL2/IL1B/CSF2/CXCL5/MAP2K4/MAP3K14/ITCH/FAS/FOS/RIPK3	45
KEGG	hsa00061	Fatty acid biosynthesis	8/3122	18/8144	0.3793	0.6201	0.4124	ACSL6/ACSBG1/MECR/ACSF3/FASN/ACSBG2/MCAT/ACACB	8
KEGG	hsa00590	Arachidonic acid metabolism	25/3122	61/8144	0.3806	0.6201	0.4124	PTGS1/GPX2/GPX1/PLA2G2D/PTGDS/PLA2G5/GPX3/PTGES2/ALOX5/ALOX12B/PLA2G6/PLA2G12B/JMJD7-PLA2G4B/PLA2G2F/PLA2G2E/PTGS2/ALOX15B/TBXAS1/PLA2G2A/PLA2G4F/PLA2G4D/PLA2G4E/PLA2G4B/CBR3/PLB1	25
KEGG	hsa00350	Tyrosine metabolism	15/3122	36/8144	0.4004	0.6492	0.4317	ALDH3B1/FAH/HPD/GSTZ1/ALDH3A1/AOC3/PNMT/DBH/AOC2/TPO/TH/IL4I1/ADH5/ALDH3B2/MAOB	15
KEGG	hsa05131	Shigellosis	97/3122	247/8144	0.4031	0.6504	0.4325	HK2/TP53/ACTN4/BNIP3/ELMO2/SQSTM1/AKT1S1/RNF31/ARPC1B/ITPR3/CYTH2/PLCB3/U2AF1L4/PIK3R3/TLN1/RELA/EGFR/GSK3B/PLCG2/BCAR1/FOXO1/IKBKB/MYL2/CAPNS1/BCL10/PLCD3/MDM2/WIPI2/CAPN1/MTOR/HK3/MAPK11/SRC/CDC42/AKT1/TLR5/CUL1/HKDC1/PLCB2/CRKL/HK1/TRADD/CTTN/IRF3/NLRP3/AKT2/ACTN1/DOCK1/ROCK2/RPTOR/ACTR3B/PFN1/TRAF2/PFN3/NOD1/FNBP1L/RRAGD/CAST/UBE2D4/MAPK12/ATG12/ATM/RIPK1/RPS6KB2/PXN/UBE2D3/PIK3CA/TRAF6/TIFA/CD44/AKT3/PIK3R2/CASP1/CBX3/PRKCE/PYCARD/IL1B/CSF2/RRAGA/CYTH3/CRK/RAC1/ATG5/MAP1LC3A/ARHGEF2/NFKBIB/ITPR1/TLN2/MYL7/UBE2D1/ARF1/ATG16L1/BCL2/ARPC5L/FBXW11/PTK2/MYLPF	97
KEGG	hsa04630	JAK-STAT signaling pathway	64/3122	162/8144	0.4076	0.6521	0.4337	IRF9/IL13/CDKN1A/STAT6/JAK3/LIF/PIK3R3/TYK2/CTF1/IFNA14/IL11RA/EGFR/IL6R/MYC/GFAP/GH2/SOS2/MTOR/LEPR/GH1/IL17D/CISH/AKT1/CSF3R/CCND1/PDGFRA/AKT2/IL2/LEP/STAT2/IL4R/THPO/IFNA13/PDGFB/PIAS3/IL22RA1/IL10/OSMR/CCND2/SOCS5/CSH1/SOCS4/PIK3CA/GHR/AKT3/CREBBP/PIK3R2/IL12RB2/IL27RA/PDGFA/PIAS2/CSF2/PDGFRB/IFNAR1/MPL/IL19/SOCS2/IL4/IL3/PRLR/BCL2/EGF/IL11/RAF1	64
KEGG	hsa04110	Cell cycle	50/3122	126/8144	0.4099	0.6521	0.4337	CHEK2/TP53/ESPL1/SMAD3/CDKN1C/CDKN1A/CCNB2/PLK1/MCM7/MAD1L1/GSK3B/ABL1/CDK2/MYC/MDM2/CDC25A/FZR1/SMC1A/CUL1/CCND1/GADD45A/CDC25C/CDC20/ZBTB17/TGFB1/ATM/STAG1/ANAPC1/ANAPC2/CDK4/CCND2/E2F4/MAD2L2/E2F1/ANAPC11/CREBBP/CHEK1/YWHAG/ANAPC10/E2F5/RBL1/CCNA2/WEE2/YWHAE/RB1/E2F3/PKMYT1/MCM5/RAD21/WEE1	50
KEGG	hsa04137	Mitophagy - animal	29/3122	72/8144	0.41	0.6521	0.4337	TP53/CSNK2B/BNIP3/SQSTM1/TAX1BP1/RELA/ATG9B/ATF4/SRC/ULK1/PINK1/MFN2/ATG9A/PGAM5/TBC1D17/MRAS/NBR1/RRAS/RHOT2/GABARAP/E2F1/TFEB/AMBRA1/ATG5/MAP1LC3A/RAB7A/FUNDC1/NRAS/GABARAPL1	29
KEGG	hsa04714	Thermogenesis	91/3122	232/8144	0.4134	0.6544	0.4351	CREB3L1/PRKACA/SMARCD3/BMP8A/AKT1S1/SLC25A20/NDUFA13/SMARCB1/NDUFV1/NDUFA8/MAP2K3/NDUFA11/NDUFA7/NDUFA6/NDUFS5/ADCY4/PRKAG1/TSC2/PRDM16/ACSL6/TSC1/NDUFB7/NPR1/PLIN1/SMARCA4/BMP8B/LIPE/SOS2/PRKACB/MTOR/ADCY5/NPPB/SIRT6/NDUFS7/MAPK11/CPT1A/NDUFS2/COX7A1/DPF3/CPT1B/RPS6KA2/NDUFS3/SDHC/PNPLA2/ADCY10/NDUFS6/MGLL/DPF1/RPTOR/COX8A/MLST8/NDUFA3/COX7B2/COX16/ADCY6/ADCY1/PRKAG3/COX19/MAPK12/MAP3K5/FGF21/ADCY9/RPS6KB2/RHEB/ADCY3/FGFR1/NDUFC2/COX6A2/UCP1/SMARCA2/CPT1C/PRKAG2/SMARCD1/NDUFA4/NDUFC1/NDUFA12/RPS6KA3/UQCRFS1/NDUFS8/SDHB/COX5A/COX4I2/COX5B/GNAS/SDHA/COX6B1/NDUFAF3/FRS2/ARID1B/NRAS/ARID1A	91
KEGG	hsa04610	Complement and coagulation cascades	34/3122	85/8144	0.4156	0.6547	0.4354	F7/F12/F2RL3/VTN/PROC/SERPINE1/CFB/CD59/F13A1/C1R/C1QA/VWF/PLAT/CR2/C1QC/SERPINA1/PROCR/PLAUR/CR1L/F2/F10/CLU/SERPINA5/BDKRB2/C1QB/C7/C2/C4A/C4B/MASP2/SERPIND1/F11/SERPINF2/SERPINC1	34
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/3122	11/8144	0.4213	0.6607	0.4394	HPD/COQ2/COQ5/COQ6/NQO1	5
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	28/3122	70/8144	0.4312	0.673	0.4475	ATP6V1F/HBEGF/ATP6V1G2/RELA/EGFR/PLCG2/IKBKB/ATP6V1A/ATP6V0E1/MAPK11/SRC/CDC42/ATP6V0C/ATP6V0A1/ATP6V1E1/JAM3/JAM2/NOD1/ATP6V0E2/TCIRG1/ATP6V0D1/MAPK12/GIT1/LYN/CXCL3/RAC1/MAP2K4/MAP3K14	28
KEGG	hsa04744	Phototransduction	12/3122	29/8144	0.4362	0.6776	0.4506	RHO/CNGB1/GUCY2D/PDE6A/PDE6B/GNAT2/CALML4/GUCA1A/GRK1/CALML6/CALML5/CALM3	12
KEGG	hsa04742	Taste transduction	34/3122	86/8144	0.4495	0.6951	0.4622	PRKACA/HCN4/ITPR3/ADCY4/PLCB3/GRM4/ENTPD2/GABRA5/PRKACB/CACNA1A/GABBR1/PLCB2/PKD2L1/TAS2R31/GABBR2/CALHM1/PDE1B/P2RX2/SCNN1G/TAS1R2/CACNA1C/ADCY6/TAS1R1/GABRA3/SCNN1A/TAS1R3/TRPM5/TAS2R39/HTR3C/GNB3/SCNN1B/PDE1C/HTR3A/GNG13	34
KEGG	hsa00510	N-Glycan biosynthesis	20/3122	50/8144	0.457	0.7034	0.4677	ALG12/MGAT3/MAN2A2/MGAT4C/DDOST/ALG6/MGAT4B/ST6GAL1/MAN1C1/MGAT5B/B4GALT2/ALG8/DPM2/ST6GAL2/ALG2/DOLPP1/MGAT5/TUSC3/DPM3/MGAT1	20
KEGG	hsa05133	Pertussis	30/3122	76/8144	0.4619	0.7077	0.4706	TICAM1/RELA/CFL1/C1R/MAPK11/C1QA/IRF3/NLRP3/CALML4/C1QC/TIRAP/NOD1/IL10/MAPK12/IL1A/C1QB/GNAI2/TRAF6/CASP1/CALML6/PYCARD/IL1B/CALML5/C2/CALM3/C4A/C4B/GNAI1/CXCL5/FOS	30
KEGG	hsa00062	Fatty acid elongation	11/3122	27/8144	0.4703	0.712	0.4735	ECHS1/ACOT7/THEM4/PPT2/MECR/ELOVL1/ACAA2/ACOT4/HSD17B12/TECR/THEM5	11
KEGG	hsa03015	mRNA surveillance pathway	38/3122	97/8144	0.4705	0.712	0.4735	MSI1/RBM8A/PPP2R5D/PPP2R5A/PPP2R1B/MSI2/PAPOLG/NXT1/RNPS1/SSU72/PABPC4L/MAGOHB/EIF4A3/CPSF1/PPP2R2C/HBS1L/PPP1CA/CPSF4/PABPN1L/NXF1/SRRM1/CLP1/CPSF2/PPP2R5B/PABPC1L/SMG6/SMG5/CASC3/CPSF3/PPP2R1A/ACIN1/PPP2R3C/UPF1/DAZAP1/CPSF6/PPP2R2A/PAPOLB/SYMPK	38
KEGG	hsa05012	Parkinson disease	103/3122	266/8144	0.4711	0.712	0.4735	TP53/PRKACA/KIF5A/SLC39A3/CAMK2A/SLC25A31/KLC4/NDUFA13/NDUFV1/NDUFA8/NDUFA11/TUBA8/NDUFA7/NDUFA6/SLC39A7/ITPR3/NDUFS5/PSMB4/SLC6A3/NDUFB7/DUSP1/KLC2/SLC39A5/PRKACB/ADCY5/TUBA3D/ATF4/SLC39A4/NDUFS7/NDUFS2/GNAL/COX7A1/SLC39A13/PSMB6/NDUFS3/PINK1/SDHC/TXN2/TUBB1/PSMD8/TUBB6/MAPT/UCHL1/NDUFS6/DRD2/UBE2J2/CALML4/MFN2/DAXX/CAMK2G/KLC3/ADORA2A/COX8A/NDUFA3/COX7B2/SLC39A14/KEAP1/KIF5B/MAP3K5/ADRM1/TUBA3E/PSMC6/TUBAL3/TH/SLC39A2/GNAI2/NDUFC2/UBE2L3/COX6A2/PSMD7/CALML6/CAMK2B/CALML5/NDUFA4/CALM3/NDUFC1/SLC18A1/NDUFA12/PSMA1/UQCRFS1/SNCA/GNAI1/NDUFS8/TUBA4A/SDHB/COX5A/COX4I2/SLC18A2/MAOB/KLC1/ITPR1/PSMC5/CAMK2D/COX5B/GNAS/SDHA/COX6B1/SLC39A1/SLC39A10/ERN1/UBA1/PARK7/PSMD9	103
KEGG	hsa00260	Glycine, serine and threonine metabolism	16/3122	40/8144	0.4734	0.7123	0.4737	GLYCTK/ALAS1/AOC3/SHMT1/AMT/SDSL/AOC2/CHDH/GCAT/PHGDH/DLD/MAOB/PSPH/DMGDH/GRHPR/CBS	16
KEGG	hsa00340	Histidine metabolism	9/3122	22/8144	0.4815	0.7212	0.4796	ALDH3B1/CNDP1/ALDH9A1/ALDH3A1/HDC/UROC1/ALDH3B2/MAOB/ALDH1B1	9
KEGG	hsa04120	Ubiquitin mediated proteolysis	55/3122	142/8144	0.4929	0.7336	0.4878	UBE2K/CDC34/CUL2/UBE3B/UBE2Q1/WWP2/MDM2/UBE2I/UBE2M/FZR1/AIRE/BIRC6/DET1/CUL1/TRIP12/MAP3K1/CUL7/UBE2Q2/UBE2J2/WWP1/CDC20/UBE2O/FBXW7/FBXO2/PIAS3/DDB2/KEAP1/UBE2D4/SMURF1/PPIL2/ANAPC1/ANAPC2/UBE2D3/UBE2L3/TRAF6/SAE1/ANAPC11/STUB1/PIAS2/VHL/PML/TRIM32/ANAPC10/CUL5/CBL/UBE2B/UBE2E2/KLHL13/ITCH/UBE2D1/UBA1/UBE3C/HUWE1/MGRN1/FBXW11	55
KEGG	hsa00053	Ascorbate and aldarate metabolism	12/3122	30/8144	0.4942	0.7336	0.4878	AKR1A1/ALDH9A1/MIOX/UGT2B15/KL/GUSB/UGDH/UGT1A1/UGT2A1/ALDH1B1/UGT2B17/UGT2A3	12
KEGG	hsa03440	Homologous recombination	16/3122	41/8144	0.5229	0.7727	0.5139	BRCA2/EME1/XRCC3/RAD54B/RPA1/BLM/TOPBP1/TOP3B/RPA3/RAD54L/POLD4/ATM/POLD1/POLD2/BRIP1/SYCP3	16
KEGG	hsa04064	NF-kappa B signaling pathway	40/3122	104/8144	0.5267	0.775	0.5154	CSNK2B/LCK/SYK/TICAM1/ZAP70/RELA/PLCG2/RELB/IKBKB/BCL10/UBE2I/EDAR/CARD11/GADD45A/TRADD/CARD14/CCL19/EDARADD/LTB/TIRAP/CCL4/PTGS2/TRAF2/TNFSF13B/CARD10/ATM/RIPK1/TRAF6/LYN/CXCL3/IL1B/CD40/BTK/PRKCB/TNFRSF13C/CCL13/BLNK/MAP3K14/BCL2/LTBR	40
KEGG	hsa00500	Starch and sucrose metabolism	14/3122	36/8144	0.5357	0.7814	0.5196	HK2/PGM2L1/GCK/HK3/HKDC1/G6PC3/HK1/GPI/TREH/PYGB/GAA/PYGM/GBE1/AMY2B	14
KEGG	hsa00512	Mucin type O-glycan biosynthesis	14/3122	36/8144	0.5357	0.7814	0.5196	ST3GAL2/ST3GAL1/GALNT9/GALNT14/GALNT6/GALNT2/GALNT7/ST6GALNAC4/ST6GALNAC2/GALNTL6/GALNT11/GALNT13/GALNT10/GALNT5	14
KEGG	hsa00515	Mannose type O-glycan biosynthesis	9/3122	23/8144	0.5474	0.788	0.524	B3GAT1/POMGNT1/FKRP/POMT1/ST3GAL3/POMT2/MGAT5B/B4GALT2/FKTN	9
KEGG	hsa03060	Protein export	9/3122	23/8144	0.5474	0.788	0.524	SRP54/OXA1L/SEC61A1/SEC61G/SEC11C/SRP14/SEC61B/SEC63/IMMP1L	9
KEGG	hsa04614	Renin-angiotensin system	9/3122	23/8144	0.5474	0.788	0.524	THOP1/REN/ANPEP/MAS1/ACE/CTSA/NLN/ATP6AP2/MRGPRD	9
KEGG	hsa05162	Measles	53/3122	139/8144	0.5524	0.7918	0.5265	TP53/CSNK2B/IRF9/TLR9/JAK3/PIK3R3/TYK2/IFNA14/RELA/BAK1/GSK3B/IKBKB/CDK2/IRF7/BAD/AKT1/BBC3/CCND1/TRADD/IRF3/AKT2/IL2/CASP8/TP73/HSPA1B/STAT2/IFNA13/HSPA1L/HSPA6/EIF2AK1/CD28/IL1A/CDK4/CCND2/PIK3CA/TRAF6/AKT3/CLEC4M/PIK3R2/OAS1/IL1B/MX1/IFNAR1/IFIH1/RAB9B/NFKBIB/EIF3H/HSPA8/HSPA1A/BCL2/FAS/FOS/MX2	53
KEGG	hsa04141	Protein processing in endoplasmic reticulum	65/3122	171/8144	0.5642	0.8052	0.5355	NPLOC4/MAP2K7/ATF6B/SEC13/SEC24C/BAK1/DNAJC1/WFS1/CAPN1/HYOU1/SIL1/ATF4/SEC61A1/CUL1/DDOST/UBQLN4/ERLEC1/SEC24A/UBE2J2/PREB/HSPA1B/DNAJB2/SEC23B/LMAN1L/TRAF2/MAN1C1/MBTPS1/FBXO2/DNAJB1/HSPA1L/HSPA6/EIF2AK1/HSP90AA1/HSPH1/CKAP4/NGLY1/UBE2D4/MAP3K5/SEL1L/PRKCSH/HSP90AB1/SEC61G/DERL3/UBE2D3/RAD23B/DNAJB12/ATXN3L/SSR1/STUB1/DNAJA1/EDEM3/CRYAA/SEC61B/HSPA8/ATXN3/SEC63/HSPA1A/TUSC3/ERN1/UBE2D1/SAR1B/BCL2/SEC24D/EDEM2/DNAJC5B	65
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/3122	26/8144	0.5686	0.8081	0.5374	PIGZ/PIGX/PIGS/PIGU/PIGQ/PIGM/DPM2/PIGG/GPAA1/PIGA	10
KEGG	hsa00480	Glutathione metabolism	22/3122	58/8144	0.5748	0.8106	0.5391	GPX2/GPX1/GSTM4/GSTT2/CHAC1/GPX3/ANPEP/GGT7/LAP3/GSTT2B/NAT8/OPLAH/IDH2/NAT8B/GSTM3/GGT6/GSS/GCLM/GSTO1/GSTA5/PRDX6/ODC1	22
KEGG	hsa00920	Sulfur metabolism	4/3122	10/8144	0.5752	0.8106	0.5391	MPST/ETHE1/TST/PAPSS2	4
KEGG	hsa03022	Basal transcription factors	17/3122	45/8144	0.5867	0.8233	0.5475	MNAT1/GTF2A1/GTF2F1/GTF2H2C/GTF2IRD1/ERCC2/TAF4B/GTF2H4/GTF2H5/GTF2H1/TAF4/GTF2I/TAF8/TAF6L/TBPL1/TAF15/TAF5	17
KEGG	hsa01232	Nucleotide metabolism	32/3122	85/8144	0.5929	0.8285	0.551	UCK1/DTYMK/NT5C1A/AK1/AK7/DCTD/ENTPD2/ADK/ENTPD6/NME2/AMPD2/CANT1/GUK1/NT5M/NT5E/PNP/NUDT16/ENTPD5/AK5/NME1-NME2/ITPA/TK1/ENTPD8/GMPR/CDA/NME7/UCKL1/DGUOK/NME4/ADSL/DCTPP1/GMPR2	32
KEGG	hsa00280	Valine, leucine and isoleucine degradation	18/3122	48/8144	0.6014	0.837	0.5566	BCKDHA/ACADS/ECHS1/ALDH9A1/HMGCLL1/ACSF3/MCCC1/AUH/ACAA2/DBT/IL4I1/PCCB/IVD/BCAT1/DLD/ALDH1B1/OXCT1/OXCT2	18
KEGG	hsa00330	Arginine and proline metabolism	19/3122	51/8144	0.6152	0.8517	0.5663	NOS1/PRODH2/CNDP1/ALDH4A1/CKMT2/CKM/OAT/ALDH9A1/LAP3/PYCR1/NOS3/CKMT1B/CKMT1A/SMOX/P4HA1/P4HA3/MAOB/ALDH1B1/ODC1	19
KEGG	hsa00860	Porphyrin metabolism	16/3122	43/8144	0.6171	0.8517	0.5663	ALAD/PPOX/UROS/ALAS1/BLVRB/HEPHL1/FXN/UGT2B15/BLVRA/GUSB/HMOX1/UGT1A1/UGT2A1/UGT2B17/HMBS/UGT2A3	16
KEGG	hsa04622	RIG-I-like receptor signaling pathway	26/3122	70/8144	0.6258	0.8564	0.5695	NLRX1/PIN1/TANK/IFNA14/RELA/IKBKB/IRF7/RNF125/MAPK11/CASP10/TRADD/MAP3K1/IRF3/CASP8/TRAF2/IFNA13/DHX58/MAPK12/ISG15/ATG12/RIPK1/TBKBP1/TRAF6/ATG5/IFIH1/NFKBIB	26
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	10/3122	27/8144	0.6264	0.8564	0.5695	ST3GAL4/FUT1/FUT6/ST3GAL3/B4GALT2/FUT5/ABO/B3GNT2/ST3GAL6/A4GALT	10
KEGG	hsa03460	Fanconi anemia pathway	20/3122	54/8144	0.6282	0.8564	0.5695	PMS2/TELO2/BRCA2/EME1/POLN/RPA1/FANCM/USP1/BLM/TOP3B/RPA3/FANCC/ERCC1/FANCG/RMI1/FANCD2/HES1/MLH1/BRIP1/ERCC4	20
KEGG	hsa05415	Diabetic cardiomyopathy	76/3122	203/8144	0.6309	0.8566	0.5696	SMAD3/PDK2/CAMK2A/SLC25A31/NDUFA13/NDUFV1/NDUFA8/NDUFA11/NDUFA7/NDUFA6/NDUFS5/PLCB3/PIK3R3/RELA/MMP2/GSK3B/REN/NDUFB7/ATP2A3/COL1A1/AGER/MTOR/NDUFS7/MAPK11/NDUFS2/AKT1/COX7A1/CPT1B/CTSD/INSR/NDUFS3/PLCB2/SDHC/PPP1CA/AKT2/NDUFS6/ATP2A1/SLC2A1/CAMK2G/COX8A/TGFBR2/NDUFA3/COX7B2/TGFB1/NCF1/PRKCZ/CYBA/SLC2A4/MAPK12/NOS3/RYR2/NDUFC2/PIK3CA/AKT3/COX6A2/PIK3R2/GFPT2/CAMK2B/PRKCA/NDUFA4/NDUFC1/NDUFA12/ACE/PDK4/RAC1/UQCRFS1/NDUFS8/COL3A1/PRKCB/SDHB/COX5A/COX4I2/CAMK2D/COX5B/SDHA/COX6B1	76
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	7/3122	19/8144	0.6377	0.8623	0.5734	GPT2/IDH2/GPT/ACO2/IDH3A/ACY1/BCAT1	7
KEGG	hsa05134	Legionellosis	21/3122	57/8144	0.6405	0.8625	0.5736	BNIP3/RELA/HSF1/CLK4/TLR5/HBS1L/EEF1A2/CASP8/HSPA1B/HSPA1L/HSPA6/CR1L/RAB1B/CXCL3/CASP1/PYCARD/IL1B/HSPA8/HSPA1A/ARF1/SAR1B	21
KEGG	hsa04672	Intestinal immune network for IgA production	18/3122	49/8144	0.6436	0.8633	0.5741	ITGB7/TNFSF13/IL2/CCR9/PIGR/TGFB1/TNFSF13B/IL10/CD28/TNFRSF17/CXCR4/CD40/TNFRSF13C/MAP3K14/CCL25/IL4/AICDA/LTBR	18
KEGG	hsa04216	Ferroptosis	15/3122	41/8144	0.6483	0.8661	0.5759	TP53/SLC7A11/PCBP2/ACSL6/SLC3A2/FTH1/FTL/SLC39A14/GSS/GCLM/FTMT/TF/ATG5/MAP1LC3A/HMOX1	15
KEGG	hsa00220	Arginine biosynthesis	8/3122	22/8144	0.6532	0.8692	0.578	NOS1/ASS1/GPT2/GPT/GLUD2/NOS3/GLUD1/ACY1	8
KEGG	hsa03018	RNA degradation	29/3122	79/8144	0.6581	0.8722	0.58	PAN3/SKIV2L/WDR61/LSM4/CNOT1/PABPC4L/ENO3/PAN2/EDC4/PFKL/BTG1/C1D/CNOT7/DCP1A/NUDT16/LSM2/DIS3L/PATL1/PABPC1L/PFKP/CNOT3/BTG3/EXOSC6/CNOT8/PNLDC1/EXOSC4/DDX6/CNOT6/ENO2	29
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	13/3122	36/8144	0.6683	0.8787	0.5843	SIRT5/SIRT4/NT5C1A/SIRT7/SIRT6/NT5M/NT5E/NADSYN1/PNP/CD38/NADK/SIRT2/ASPDH	13
KEGG	hsa03030	DNA replication	13/3122	36/8144	0.6683	0.8787	0.5843	POLA2/MCM7/RNASEH2A/RPA1/POLE/RPA3/POLD4/POLD1/POLD2/DNA2/FEN1/MCM5/PRIM1	13
KEGG	hsa03420	Nucleotide excision repair	17/3122	47/8144	0.6724	0.8807	0.5857	MNAT1/GTF2H2C/ERCC2/RPA1/POLE/ERCC5/GTF2H4/DDB2/GTF2H5/RPA3/GTF2H1/POLD4/ERCC1/POLD1/RAD23B/POLD2/ERCC4	17
KEGG	hsa00240	Pyrimidine metabolism	21/3122	58/8144	0.6777	0.8842	0.588	UCK1/DTYMK/NT5C1A/DCTD/ENTPD6/NME2/CAD/CANT1/NT5M/NT5E/NUDT2/ENTPD5/NME1-NME2/TK1/ENTPD8/CDA/NME7/UCKL1/UPB1/NME4/DCTPP1	21
KEGG	hsa00100	Steroid biosynthesis	7/3122	20/8144	0.6993	0.9088	0.6044	DHCR24/DHCR7/TM7SF2/CEL/CYP27B1/CYP51A1/SQLE	7
KEGG	hsa03430	Mismatch repair	8/3122	23/8144	0.7097	0.9153	0.6087	PMS2/RPA1/RPA3/POLD4/POLD1/POLD2/MSH6/MLH1	8
KEGG	hsa04060	Cytokine-cytokine receptor interaction	109/3122	295/8144	0.7111	0.9153	0.6087	GDF11/IL13/CSF1/TNFRSF10D/BMPR2/GDF10/BMP8A/ACVRL1/ACVR2B/CD4/GDF5/LIF/AMHR2/TNFSF9/NGF/CTF1/IFNA14/IL11RA/IL6R/BMP8B/GH2/EDAR/TNFRSF1B/IL1RL2/LEPR/GH1/TNFSF12/IL17D/CSF3R/TNFSF13/CXCR5/TNFRSF8/IL2/CCL19/GDF7/LEP/AMH/LTB/IL4R/CCL4/THPO/IFNA13/CCR9/TNFRSF10C/TGFBR2/TNFRSF4/XCR1/CCR7/IL22RA1/TGFB1/IL17B/CCL24/IL1RN/TNFSF13B/IL10/TNFRSF12A/GDF2/IL1A/CX3CL1/BMPR1B/IL34/ACVR2A/OSMR/TNFRSF17/CXCR4/IL32/CSH1/BMP4/IL31/GHR/CCR6/CXCL3/IL12RB2/CCL2/CCL1/BMP2/IL27RA/IL1B/CD40/CSF2/RELT/IFNAR1/CCL16/CXCL17/MPL/IL19/CXCL5/TNFRSF25/BMP3/CXCR3/TNFRSF10A/TNFRSF13C/BMP7/CCL13/TNFRSF18/TNFRSF10B/CSF1R/CCL25/IL4/IL3/TNFRSF19/PRLR/FAS/IL25/IL11/LTBR/NGFR/IL27/CCL27	109
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	13/3122	37/8144	0.7125	0.9153	0.6087	ASS1/GPT2/ALDH4A1/NAT8L/FOLH1/CAD/GPT/GLUD2/NIT2/IL4I1/GLUD1/GFPT2/ADSL	13
KEGG	hsa04621	NOD-like receptor signaling pathway	67/3122	184/8144	0.7308	0.9318	0.6196	IRF9/PSTPIP1/TICAM1/RNF31/CARD9/NLRX1/ITPR3/PLCB3/TANK/TYK2/NOD2/IFNA14/RELA/IKBKB/CTSB/SUGT1/IRF7/NLRP1/MAPK11/CARD6/PLCB2/TXN2/IRF3/NLRP3/CASP8/PANX1/MFN2/PKN1/STAT2/TRAF2/IFNA13/NOD1/CASR/GBP3/HSP90AA1/IFI16/CYBA/MAPK12/HSP90AB1/ATG12/RIPK1/NLRP6/DHX33/TRAF6/CARD16/GABARAP/CXCL3/OAS1/CCL2/CASP1/PYCARD/IL1B/GBP5/ATG5/IFNAR1/MAP1LC3A/NFKBIB/DEFA4/ITPR1/TXNIP/TRPM7/ATG16L1/BCL2/YWHAE/GABARAPL1/RIPK3/CAMP	67
KEGG	hsa00071	Fatty acid degradation	15/3122	43/8144	0.7309	0.9318	0.6196	ACADS/ECHS1/ACADVL/ACOX3/ACSL6/ALDH9A1/CPT1A/CPT1B/ACSBG1/ACAA2/CPT1C/ADH5/ACSBG2/ACOX1/ALDH1B1	15
KEGG	hsa00640	Propanoate metabolism	11/3122	32/8144	0.737	0.936	0.6224	BCKDHA/ACADS/ECHS1/ACOX3/LDHB/DBT/PCCB/ACSS1/DLD/ACOX1/ACACB	11
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/3122	15/8144	0.7421	0.9389	0.6243	ST3GAL2/ST3GAL1/GBGT1/FUT1/A4GALT	5
KEGG	hsa05203	Viral carcinogenesis	74/3122	204/8144	0.7527	0.9427	0.6269	TP53/ACTN4/GTF2A1/IRF9/SYK/CREB3L1/SCIN/CDKN1A/PRKACA/CHD4/MAPKAPK2/GTF2H2C/JAK3/ATF6B/PIK3R3/RELA/BAK1/KAT2A/HDAC5/MAD1L1/SCRIB/CDK2/IRF7/HNRNPK/MDM2/PRKACB/ATF4/HLA-G/SRC/CDC42/BAD/CCND1/TRADD/IRF3/HDAC4/ACTN1/CASP8/CDC20/VAC14/TRAF2/GTF2H4/HLA-F/GSN/GTF2H1/ATP6V0D1/HDAC11/CDK4/PXN/CCND2/PIK3CA/RANBP1/LYN/CREBBP/PIK3R2/PMAIP1/SND1/RBPJ/CHEK1/YWHAG/UBR4/RAC1/USP7/HDAC7/SP100/RBPJL/RBL1/TBPL1/NRAS/CCNA2/HPN/YWHAE/LTBR/RB1/HDAC6	74
KEGG	hsa04623	Cytosolic DNA-sensing pathway	22/3122	63/8144	0.753	0.9427	0.6269	POLR3E/POLR3GL/POLR2E/POLR1D/IFNA14/RELA/IKBKB/IRF7/POLR2F/POLR3B/POLR3H/IRF3/CCL4/IFNA13/POLR3G/RIPK1/CASP1/PYCARD/IL1B/NFKBIB/POLR2L/RIPK3	22
KEGG	hsa00770	Pantothenate and CoA biosynthesis	7/3122	21/8144	0.7536	0.9427	0.6269	PANK1/PPCDC/CSAD/PANK3/BCAT1/ALDH1B1/UPB1	7
KEGG	hsa00020	Citrate cycle (TCA cycle)	10/3122	30/8144	0.7719	0.9525	0.6334	SDHC/IDH2/PC/ACO2/DLST/IDH3A/DLD/SDHB/ACLY/SDHA	10
KEGG	hsa00030	Pentose phosphate pathway	10/3122	30/8144	0.7719	0.9525	0.6334	ALDOC/ALDOA/GLYCTK/FBP1/PFKL/TKT/GPI/PFKP/H6PD/FBP2	10
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	10/3122	30/8144	0.7719	0.9525	0.6334	GLYCTK/SHMT1/AMT/AFMID/ACO2/PCCB/ACSS1/DLD/GRHPR/PGP	10
KEGG	hsa00620	Pyruvate metabolism	16/3122	47/8144	0.7739	0.9525	0.6334	PKLR/HAGH/AKR1A1/ALDH9A1/LDHB/PC/ME1/LDHD/ME3/ACSS1/ADH5/DLD/ALDH1B1/ACACB/GLO1/GRHPR	16
KEGG	hsa00140	Steroid hormone biosynthesis	21/3122	61/8144	0.7757	0.9525	0.6334	CYP11A1/AKR1C4/CYP3A5/CYP7A1/DHRS11/CYP3A4/HSD11B2/SULT2B1/CYP21A2/HSD11B1L/UGT2B15/CYP7B1/CYP3A7/STS/CYP1B1/HSD17B12/UGT1A1/UGT2A1/UGT2B17/CYP1A2/UGT2A3	21
KEGG	hsa00600	Sphingolipid metabolism	18/3122	53/8144	0.7864	0.9621	0.6398	NEU1/NEU2/SMPD3/SGPP1/ASAH1/SPHK2/B4GALNT1/PSAP/GBA/SPTLC1/ENPP7/ACER1/SPTLC3/GBA2/NEU4/GAL3ST1/UGT8/GLB1	18
KEGG	hsa00513	Various types of N-glycan biosynthesis	13/3122	39/8144	0.7893	0.9621	0.6398	ALG12/MAN2A2/CHST8/MGAT4C/ST3GAL3/DDOST/B4GALNT3/MGAT4B/MAN1C1/B4GALT2/ALG2/TUSC3/MGAT1	13
KEGG	hsa00380	Tryptophan metabolism	14/3122	42/8144	0.7948	0.9651	0.6418	ECHS1/ALDH9A1/DHTKD1/AFMID/AANAT/DLST/IDO2/IL4I1/CYP1B1/INMT/DLD/MAOB/ALDH1B1/CYP1A2	14
KEGG	hsa00430	Taurine and hypotaurine metabolism	5/3122	16/8144	0.7975	0.9651	0.6418	GGT7/CSAD/GGT6/FMO1/FMO5	5
KEGG	hsa04620	Toll-like receptor signaling pathway	36/3122	104/8144	0.8119	0.972	0.6464	TLR9/MAP2K7/TICAM1/MAP2K3/PIK3R3/IFNA14/RELA/IKBKB/IRF7/TOLLIP/MAP2K2/TLR1/MAP2K1/MAPK11/AKT1/TLR5/IRF3/AKT2/CASP8/TIRAP/TLR3/CCL4/IFNA13/MAPK12/RIPK1/PIK3CA/TRAF6/AKT3/PIK3R2/IL1B/CTSK/CD40/RAC1/IFNAR1/MAP2K4/FOS	36
KEGG	hsa00040	Pentose and glucuronate interconversions	11/3122	34/8144	0.8139	0.972	0.6464	AKR1A1/AKR1B1/UGT2B15/KL/AKR1B10/GUSB/UGDH/UGT1A1/UGT2A1/UGT2B17/UGT2A3	11
KEGG	hsa04217	Necroptosis	56/3122	159/8144	0.8151	0.972	0.6464	CHMP6/IRF9/SQSTM1/CAMK2A/SLC25A31/TICAM1/RNF31/STAT6/JAK3/SPATA2L/VPS4A/TYK2/IFNA14/CHMP2A/SPATA2/CAPN1/JMJD7-PLA2G4B/TRADD/NLRP3/CASP8/CAMK2G/STAT2/TLR3/PGAM5/TRAF2/IFNA13/FTH1/FTL/GLUD2/PYGB/HSP90AA1/IL1A/HSP90AB1/RIPK1/PLA2G4F/PLA2G4D/PYGM/GLUD1/CASP1/CAMK2B/PYCARD/IL1B/AIFM1/USP21/IFNAR1/PLA2G4E/PLA2G4B/CHMP1A/CAMK2D/TNFRSF10A/TNFRSF10B/TRPM7/BCL2/FAS/CHMP4A/RIPK3	56
KEGG	hsa05020	Prion disease	98/3122	273/8144	0.8173	0.972	0.6464	CSNK2B/CREB3L1/PRKACA/KIF5A/SLC25A31/KLC4/NOTCH1/NDUFA13/NDUFV1/NDUFA8/NDUFA11/TUBA8/NDUFA7/ATF6B/NDUFA6/ITPR3/NDUFS5/CACNA1S/PSMB4/PIK3R3/GSK3B/NCAM1/NDUFB7/KLC2/GRIN2D/PRKACB/TUBA3D/ATF4/NDUFS7/MAPK11/NDUFS2/BAD/C1QA/COX7A1/PSMB6/NDUFS3/SDHC/TUBB1/PSMD8/TUBB6/NDUFS6/C1QC/HSPA1B/GRIN2B/CACNA1D/KLC3/CACNA1B/COX8A/CAV3/NDUFA3/COX7B2/CACNA1C/GRIN2C/HSPA1L/HSPA6/NCF1/RYR1/KIF5B/CYBA/MAPK12/ADRM1/IL1A/RYR2/TUBA3E/PSMC6/C1QB/TUBAL3/C7/NDUFC2/PIK3CA/COX6A2/PIK3R2/GRIN2A/PSMD7/PPP3CA/IL1B/NDUFA4/NDUFC1/NDUFA12/PSMA1/RAC1/UQCRFS1/GRIN1/NDUFS8/TUBA4A/SDHB/COX5A/COX4I2/KLC1/ITPR1/PSMC5/COX5B/SDHA/HSPA8/COX6B1/HSPA1A/CACNA1F/PSMD9	98
KEGG	hsa05143	African trypanosomiasis	12/3122	37/8144	0.8178	0.972	0.6464	TLR9/THOP1/PLCB3/PLCB2/APOL1/HBB/IL10/IDO2/PRKCA/IL1B/PRKCB/FAS	12
KEGG	hsa05164	Influenza A	60/3122	171/8144	0.8319	0.9853	0.6552	IRF9/SLC25A31/TICAM1/NLRX1/PIK3R3/TYK2/IFNA14/RELA/BAK1/NXT1/IKBKB/IRF7/MAP2K2/MAP2K1/AKT1/FDPS/RAB11A/TRADD/IRF3/NLRP3/AKT2/CASP8/CPSF4/STAT2/PABPN1L/TLR3/NXF1/KPNA2/IFNA13/DNAJB1/PRSS3/IL1A/TPSD1/CDK4/PIK3CA/XPO1/AKT3/CREBBP/TMPRSS4/PIK3R2/OAS1/CCL2/CASP1/PYCARD/PRKCA/IL1B/MX1/PML/IFNAR1/CIITA/PRKCB/IFIH1/NFKBIB/TNFRSF10A/TNFRSF10B/RAB11B/FAS/RAF1/MX2/KPNA5	60
KEGG	hsa04659	Th17 cell differentiation	37/3122	108/8144	0.8355	0.9861	0.6557	LCK/SMAD3/IRF4/RXRB/CD4/STAT6/JAK3/ZAP70/NFATC1/TYK2/RELA/IKBKB/RARA/IL6R/MTOR/MAPK11/IL2/RXRA/IL4R/TGFBR2/TGFB1/NFATC2/HSP90AA1/MAPK12/HSP90AB1/RORA/RORC/IL27RA/PPP3CA/IL1B/TBX21/NFKBIB/RXRG/IL4/FOS/IL27/NFKBIE	37
KEGG	hsa00790	Folate biosynthesis	8/3122	26/8144	0.8405	0.9881	0.6571	AKR1B1/GCH1/ALPP/MOCOS/TH/PCBD1/AKR1B10/ALPL	8
KEGG	hsa00450	Selenocompound metabolism	5/3122	17/8144	0.8431	0.9881	0.6571	TXNRD1/TXNRD2/INMT/SEPHS2/PAPSS2	5
KEGG	hsa01240	Biosynthesis of cofactors	53/3122	153/8144	0.8493	0.9893	0.6578	MPI/ALAD/PANK1/PPOX/HPD/PPCDC/COQ2/AK1/AK7/AKR1A1/UROS/PMM1/ALAS1/COQ5/COQ6/PNPO/NME2/PDXK/CAD/SHMT1/DHRS3/NFS1/AFMID/GCH1/NADSYN1/PDXP/ALPP/GSS/GCLM/UGT2B15/AK5/IDO2/NME1-NME2/NADK/PANK3/BCAT1/GUSB/DLD/PMM2/UGDH/UGT1A1/UGT2A1/ALDH1B1/UGT2B17/ASPDH/NME7/ALPL/NME4/HMBS/UGT2A3/GMPPA/ADSL/NQO1	53
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	45/3122	131/8144	0.8501	0.9893	0.6578	LCK/SYK/SHC4/SHC2/ZAP70/NFATC1/PIK3R3/IFNA14/PLCG2/MICA/SHC3/VAV2/SH3BP2/MICB/PRF1/SOS2/MAP2K2/VAV1/MAP2K1/HLA-G/SHC1/TYROBP/KIR3DL2/PTK2B/IFNA13/NFATC2/ITGAL/PIK3CA/PIK3R2/PPP3CA/PRKCA/CSF2/RAC1/IFNAR1/PRKCB/RAC3/TNFRSF10A/LCP2/VAV3/TNFRSF10B/NRAS/FAS/RAF1/FCGR3A/ARAF	45
KEGG	hsa05145	Toxoplasmosis	38/3122	112/8144	0.8565	0.9933	0.6605	MAP2K3/PIK3CG/TYK2/RELA/LAMC2/LAMA1/IKBKB/LDLR/ALOX5/PDPK1/MAPK11/BAD/AKT1/LAMB3/AKT2/LAMA5/CASP8/IRGM/HSPA1B/HSPA1L/TGFB1/HSPA6/IL10/PIK3R6/MAPK12/LAMA3/GNAI2/TRAF6/AKT3/CD40/ITGA6/GNAI1/CIITA/NFKBIB/HSPA8/HSPA1A/BCL2/LAMC3	38
KEGG	hsa05014	Amyotrophic lateral sclerosis	130/3122	364/8144	0.8661	0.9999	0.6649	TP53/GPX2/GPX1/NOS1/SQSTM1/NRG2/KIF5A/ACTR1B/KLC4/NDUFA13/NDUFV1/NDUFA8/MAP2K3/NDUFA11/POM121/TUBA8/NDUFA7/SEC13/NDUFA6/ITPR3/NDUFS5/PSMB4/DNAI2/TANK/NXT1/DNAH14/GPX3/DNAI1/NDUFB7/ANXA11/KLC2/NUP62/WIPI2/GRIN2D/NUP107/TNFRSF1B/MTOR/TUBA3D/ATF4/NDUFS7/MAPK11/POM121C/NDUFS2/DNAH17/BAD/COX7A1/PSMB6/DNAH2/ULK1/DCTN1/NDUFS3/PINK1/CCS/SDHC/NUP155/UBQLN4/HAP1/TUBB1/DNAH1/PSMD8/TUBB6/NDUFS6/TOMM40/GRIN2B/SLC1A2/DAXX/NXF1/KLC3/PFN1/DNAH10/TRAF2/PFN3/COX8A/NUP210/NDUFA3/COX7B2/GRIN2C/ACTR10/DNAL4/ERBB4/ATXN2/KIF5B/MAPK12/MAP3K5/ADRM1/DNAH11/ATXN2L/TUBA3E/PSMC6/TUBAL3/NDUFC2/COX6A2/TOMM40L/DNAH3/GRIN2A/ULK2/AMBRA1/PSMD7/CASP1/DNALI1/PPP3CA/NDUFA4/NUP85/NDUFC1/NDUFA12/HNRNPA3/PSMA1/RAC1/NUP50/UQCRFS1/GRIN1/MAP1LC3A/NRBF2/NDUFS8/TUBA4A/SDHB/COX5A/COX4I2/KLC1/PSMC5/ATG2B/COX5B/ANG/SDHA/COX6B1/ERN1/DCTN6/BCL2/PSMD9/HDAC6	130
KEGG	hsa04130	SNARE interactions in vesicular transport	10/3122	33/8144	0.8719	0.9999	0.6649	STX1A/STX3/STX11/YKT6/STX1B/USE1/BNIP1/STX4/VTI1B/STX8	10
KEGG	hsa03040	Spliceosome	50/3122	147/8144	0.8802	0.9999	0.6649	RBM8A/SF3A3/SNRNP200/DHX8/LSM4/U2AF1L4/DHX16/PPIH/PPIE/HNRNPK/TRA2A/SART1/MAGOHB/SNRNP70/PRPF38A/PRPF6/PPIL1/EIF4A3/DDX23/SF3A2/SF3B1/U2AF2/EFTUD2/SF3A1/HSPA1B/CHERP/THOC1/USP39/AQR/HSPA1L/HSPA6/LSM2/PRPF31/CCDC12/SNRPD2/BUD31/ACIN1/SNRPA/SYF2/HNRNPA3/SNRPG/HNRNPC/PUF60/DDX5/HSPA8/TRA2B/HSPA1A/XAB2/CDC5L/PRPF40B	50
KEGG	hsa03013	Nucleocytoplasmic transport	36/3122	108/8144	0.8808	0.9999	0.6649	TNPO3/RBM8A/TNPO2/POM121/SNUPN/SEC13/NXT1/RNPS1/NUP62/UBE2I/MAGOHB/NUP107/EIF4A3/POM121C/IPO13/NUP155/AHCTF1/EEF1A2/NXF1/SRRM1/KPNA2/THOC1/NUP210/IPO4/IPO9/SUMO4/NMD3/CASC3/ACIN1/XPO1/NUP85/NUP50/UPF1/SUMO3/AAAS/KPNA5	36
KEGG	hsa05416	Viral myocarditis	19/3122	60/8144	0.8859	0.9999	0.6649	ABL1/LAMA1/EIF4G1/PRF1/HLA-G/CCND1/SGCD/CASP8/DAG1/HLA-F/ITGAL/MYH7/CD28/MYH6/CD40/SGCA/RAC1/RAC3/SGCG	19
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	33/3122	100/8144	0.8872	0.9999	0.6649	CSF1/TNFRSF10D/IL6R/TNFRSF1B/CXCR5/IL2/CCL19/CCL4/CCR9/TNFRSF10C/XCR1/CCR7/IL22RA1/CCL24/IL10/CX3CL1/IL34/CXCR4/CCR6/CXCL3/CCL2/CCL1/CCL16/IL19/CXCL5/CXCR3/TNFRSF10A/CCL13/TNFRSF10B/CSF1R/CCL25/LTBR/CCL27	33
KEGG	hsa00310	Lysine degradation	20/3122	63/8144	0.8879	0.9999	0.6649	ECHS1/PLOD3/PLOD1/PRDM16/SETDB2/EHMT2/ALDH9A1/DOT1L/PLOD2/SETD1B/DHTKD1/DLST/SETD1A/EHMT1/PRDM9/EZH1/NSD1/SMYD2/DLD/ALDH1B1	20
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	22/3122	69/8144	0.892	0.9999	0.6649	GSTM4/GSTT2/CYP3A5/SULT1A1/SULT1A3/SULT1A4/GSTT2B/EPHX1/CYP3A4/PTGS2/GSTM3/HSD11B1L/UGT2B15/CYP3A7/GSTO1/CYP1B1/UGT1A1/UGT2A1/GSTA5/UGT2B17/CYP1A2/UGT2A3	22
KEGG	hsa01230	Biosynthesis of amino acids	24/3122	75/8144	0.896	0.9999	0.6649	ALDOC/ALDOA/ASS1/PKLR/GPT2/ENO3/PFKL/TPI1/SHMT1/TKT/PYCR1/IDH2/GPT/SDSL/PC/ACO2/PFKP/PHGDH/IDH3A/ACY1/BCAT1/PSPH/CBS/ENO2	24
KEGG	hsa03050	Proteasome	14/3122	46/8144	0.8972	0.9999	0.6649	PSMB4/PSMB11/PSME1/PSMB6/PSME3/PSMD8/PSMB9/ADRM1/PSMC6/PSMB8/PSMD7/PSMA1/PSMC5/PSMD9	14
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	25/3122	78/8144	0.898	0.9999	0.6649	ALDH3B1/GSTM4/GSTT2/CYP3A5/ALDH3A1/GSTT2B/EPHX1/CYP3A4/GSTM3/HSD11B1L/CYP2S1/UGT2B15/CYP2F1/GSTO1/CYP1B1/ADH5/ALDH3B2/AKR7A2/UGT1A1/UGT2A1/CBR3/GSTA5/UGT2B17/CYP1A2/UGT2A3	25
KEGG	hsa00650	Butanoate metabolism	8/3122	28/8144	0.8981	0.9999	0.6649	ACADS/ECHS1/BDH1/HMGCLL1/ACSM3/ACSM1/OXCT1/OXCT2	8
KEGG	hsa05152	Tuberculosis	61/3122	180/8144	0.9071	1	0.665	SYK/TLR9/CAMK2A/CARD9/LSP1/CLEC4E/NOD2/RAB5C/IFNA14/RELA/SPHK2/CTSS/BCL10/TLR1/MAPK11/SRC/BAD/AKT1/CTSD/CASP10/ATP6V0C/TRADD/ATP6V0A1/NFYB/VDR/AKT2/CALML4/CASP8/CAMK2G/TIRAP/IFNA13/KSR1/TCIRG1/TGFB1/CR1L/IL10/ATP6V0D1/MAPK12/IL1A/CYP27B1/MRC2/TRAF6/AKT3/CREBBP/CLEC4M/CALML6/PPP3CA/CAMK2B/IL1B/PLA2R1/CALML5/CALM3/CIITA/RAB7A/CAMK2D/CD74/BCL2/RAF1/FCGR3A/ARHGEF12/CAMP	61
KEGG	hsa04215	Apoptosis - multiple species	9/3122	32/8144	0.9176	1	0.665	BAK1/BIRC5/BOK/BIRC6/BBC3/CASP8/PMAIP1/BCL2/NGFR	9
KEGG	hsa00190	Oxidative phosphorylation	44/3122	134/8144	0.9218	1	0.665	NDUFA13/NDUFV1/NDUFA8/NDUFA11/ATP6V1F/LHPP/NDUFA7/NDUFA6/ATP6V1G2/NDUFS5/NDUFB7/ATP6V1A/ATP6V0E1/NDUFS7/NDUFS2/COX7A1/NDUFS3/ATP6V0C/SDHC/ATP6V0A1/ATP6V1E1/PPA2/NDUFS6/COX8A/NDUFA3/COX7B2/ATP6V0E2/TCIRG1/ATP6V0D1/ATP4A/NDUFC2/COX6A2/NDUFA4/NDUFC1/NDUFA12/UQCRFS1/NDUFS8/ATP4B/SDHB/COX5A/COX4I2/COX5B/SDHA/COX6B1	44
KEGG	hsa00270	Cysteine and methionine metabolism	15/3122	51/8144	0.93	1	0.665	DNMT3A/MPST/DNMT3B/LDHB/SDSL/TST/GSS/GCLM/DNMT1/BHMT2/APIP/IL4I1/PHGDH/BCAT1/CBS	15
KEGG	hsa04612	Antigen processing and presentation	24/3122	78/8144	0.9347	1	0.665	CD4/CD8B/CTSS/CTSB/HSPA4/HLA-G/PSME1/KIR3DL2/NFYB/PSME3/TAPBP/HSPA1B/HSPA1L/HSPA6/HLA-F/HSP90AA1/HSP90AB1/CD8A/CIITA/TAP1/CD74/TAP2/HSPA8/HSPA1A	24
KEGG	hsa01523	Antifolate resistance	8/3122	30/8144	0.9371	1	0.665	RELA/SLC46A1/ABCC1/IKBKB/MTHFR/SHMT1/FOLR1/IL1B	8
KEGG	hsa05323	Rheumatoid arthritis	29/3122	93/8144	0.9391	1	0.665	CSF1/ATP6V1F/ATP6V1G2/ATP6V1A/ATP6V0E1/VEGFA/TNFSF13/ATP6V0C/ATP6V0A1/ATP6V1E1/LTB/FLT1/ATP6V0E2/TCIRG1/TGFB1/TNFSF13B/ATP6V0D1/ITGAL/CD28/IL1A/ANGPT1/CXCL3/CCL2/IL1B/CTSK/CSF2/CXCL5/FOS/IL11	29
KEGG	hsa04657	IL-17 signaling pathway	29/3122	94/8144	0.9478	1	0.665	MAPK7/IL13/ELAVL1/MAPK4/RELA/GSK3B/IKBKB/MAPK11/IL17D/TRADD/CASP8/TRAF4/PTGS2/TRAF2/MAPK6/IL17B/HSP90AA1/MAPK12/HSP90AB1/TRAF6/CXCL3/CCL2/MAPK15/IL1B/CSF2/CXCL5/IL4/IL25/FOS	29
KEGG	hsa04145	Phagosome	49/3122	152/8144	0.9513	1	0.665	THBS3/DYNC1H1/NOS1/THBS2/ATP6V1F/TUBA8/ATP6V1G2/RAB5C/CTSS/SCARB1/ITGA2/ATP6V1A/ATP6V0E1/STX12/TUBA3D/C1R/HLA-G/SEC61A1/ATP6V0C/ITGB3/ATP6V0A1/ATP6V1E1/TUBB1/TUBB6/COLEC11/COLEC12/ATP6V0E2/TCIRG1/HLA-F/NCF1/ATP6V0D1/CYBA/HGS/MRC2/TUBA3E/TUBAL3/SEC61G/CLEC4M/PLA2R1/RAC1/TUBA4A/TAP1/RAB7A/ITGAV/SEC61B/SFTPD/ITGB5/TAP2/FCGR3A	49
KEGG	hsa00983	Drug metabolism - other enzymes	24/3122	80/8144	0.9531	1	0.665	UCK1/GSTM4/GSTT2/NME2/GSTT2B/CYP3A4/GSTM3/CES2/UGT2B15/NME1-NME2/ITPA/GSTO1/TK1/GUSB/UGT1A1/UGT2A1/GSTA5/UGT2B17/CDA/NME7/UCKL1/UPB1/NME4/UGT2A3	24
KEGG	hsa04658	Th1 and Th2 cell differentiation	28/3122	92/8144	0.9548	1	0.665	LCK/IL13/NOTCH3/CD4/NOTCH1/STAT6/JAK3/ZAP70/NFATC1/TYK2/RELA/IKBKB/MAPK11/IL2/DLL4/IL4R/NFATC2/MAPK12/IL12RB2/PPP3CA/RBPJ/TBX21/NFKBIB/RBPJL/RUNX3/IL4/FOS/NFKBIE	28
KEGG	hsa00982	Drug metabolism - cytochrome P450	21/3122	72/8144	0.9602	1	0.665	ALDH3B1/GSTM4/GSTT2/CYP3A5/ALDH3A1/GSTT2B/CYP3A4/GSTM3/UGT2B15/FMO1/GSTO1/ADH5/ALDH3B2/UGT1A1/MAOB/UGT2A1/GSTA5/UGT2B17/FMO5/CYP1A2/UGT2A3	21
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/3122	22/8144	0.9625	1	0.665	MVD/FDPS/IDI1/GGPS1/HMGCR	5
KEGG	hsa05321	Inflammatory bowel disease	18/3122	65/8144	0.9735	1	0.665	SMAD3/IL13/STAT6/NFATC1/NOD2/RELA/TLR5/IL2/IL4R/TGFB1/IL10/IL1A/RORA/RORC/IL12RB2/IL1B/TBX21/IL4	18
KEGG	hsa05144	Malaria	13/3122	50/8144	0.9767	1	0.665	THBS3/TLR9/THBS2/CD81/HBB/TGFB1/CR1L/LRP1/IL10/ITGAL/CCL2/IL1B/CD40	13
KEGG	hsa05171	Coronavirus disease - COVID-19	75/3122	232/8144	0.977	1	0.665	IRF9/SYK/RPL3L/HBEGF/RPL7/CFB/PIK3R3/TYK2/RPS28/IFNA14/RELA/EGFR/PLCG2/IKBKB/IL6R/RPS19/F13A1/C1R/MAPK11/C1QA/VWF/IRF3/NLRP3/IL2/RPL10L/RPS15A/C1QC/STAT2/TLR3/RPS3/IFNA13/RPL38/RPL27/F2/MAS1/RPL30/MAPK12/ISG15/C1QB/C7/RPS25/PIK3CA/TRAF6/RPS21/RPS8/RPL9/PIK3R2/OAS1/CCL2/RPLP2/RPL22/CASP1/PRKCA/IL1B/MX1/C2/C4A/C4B/RPL3/RPS10/CSF2/ACE/MASP2/IFNAR1/PRKCB/RPL24/IFIH1/NFKBIB/RPL41/RPL34/FOS/RPL23A/RPS15/RPL13A/MX2	75
KEGG	hsa00670	One carbon pool by folate	4/3122	20/8144	0.9773	1	0.665	MTHFR/SHMT1/AMT/ALDH1L1	4
KEGG	hsa05310	Asthma	7/3122	31/8144	0.9803	1	0.665	IL13/IL10/CD40/PRG2/EPX/IL4/IL3	7
KEGG	hsa04146	Peroxisome	23/3122	82/8144	0.9811	1	0.665	ACOT8/ACOX3/PRDX1/ACSL6/CRAT/PEX19/PAOX/IDH2/PEX26/MPV17L/HMGCLL1/SLC25A17/PEX11G/PEX14/PEX10/DECR2/SCP2/PEX5L/SOD2/PXMP4/ACOX1/PRDX5/HSD17B4	23
KEGG	hsa05330	Allograft rejection	9/3122	38/8144	0.9817	1	0.665	PRF1/HLA-G/IL2/HLA-F/IL10/CD28/CD40/IL4/FAS	9
KEGG	hsa05034	Alcoholism	58/3122	187/8144	0.9855	1	0.665	CREB3L1/PRKACA/SHC4/GNG3/SLC29A3/SHC2/ATF6B/PPP1R1B/HDAC5/SLC6A3/SHC3/SOS2/GRIN2D/PRKACB/ADCY5/ATF4/MAP2K1/SHC1/GNG12/CAMKK2/PPP1CA/HDAC4/DRD2/BDNF/CALML4/GRIN2B/GNG5/ADORA2A/PDYN/GRIN2C/GNB4/HDAC11/SLC29A2/TH/GNAI2/GRIN2A/CAMKK1/CALML6/CALML5/CALM3/NTRK2/SLC18A1/GRIN1/CAMK4/GNAI1/HDAC7/GNB3/GNB2/SLC18A2/MAOB/GNG4/GNAS/NPY/NRAS/RAF1/GNG13/HDAC6/ARAF	58
KEGG	hsa00830	Retinol metabolism	18/3122	68/8144	0.9859	1	0.665	RDH5/CYP3A5/PNPLA4/DHRS3/ALDH1A1/CYP3A4/CYP2W1/CYP2S1/UGT2B15/CYP3A7/ADH5/CYP26B1/UGT1A1/UGT2A1/UGT2B17/CYP1A2/DGAT1/UGT2A3	18
KEGG	hsa04940	Type I diabetes mellitus	10/3122	43/8144	0.9883	1	0.665	PTPRN2/PRF1/HLA-G/IL2/HLA-F/CD28/IL1A/PTPRN/IL1B/FAS	10
KEGG	hsa05320	Autoimmune thyroid disease	13/3122	53/8144	0.9886	1	0.665	TG/IFNA14/PRF1/HLA-G/IL2/IFNA13/TPO/HLA-F/IL10/CD28/CD40/IL4/FAS	13
KEGG	hsa05140	Leishmaniasis	20/3122	77/8144	0.9922	1	0.665	RELA/MAPK11/EEF1A2/PTGS2/TGFB1/CR1L/NCF1/IL10/CYBA/MARCKSL1/MAPK12/IL1A/TRAF6/IL1B/PRKCB/NFKBIB/ELK1/IL4/FOS/FCGR3A	20
KEGG	hsa05332	Graft-versus-host disease	9/3122	42/8144	0.994	1	0.665	PRF1/HLA-G/KIR3DL2/IL2/HLA-F/CD28/IL1A/IL1B/FAS	9
KEGG	hsa05150	Staphylococcus aureus infection	24/3122	96/8144	0.9981	1	0.665	KRT14/CFB/PTAFR/C1R/C1QA/KRT20/C1QC/DEFB1/KRT31/IL10/ITGAL/KRT19/C1QB/KRT15/C2/KRT35/C4A/C4B/KRT18/MASP2/DEFA4/FCGR3A/CAMP/KRT33B	24
KEGG	hsa03010	Ribosome	37/3122	158/8144	1	1	0.665	MRPL4/RPL3L/RPL7/RPS28/MRPL23/RPS19/MRPL27/MRPL28/RPL10L/RPS15A/MRPS2/RPS3/RPL38/MRPL10/RPL27/RPL30/MRPS11/RPS25/RPS21/RPS8/MRPL2/RPL9/MRPL35/RPLP2/RPL22/RPL3/RPS10/RPL24/MRPS9/RPL41/RPL34/RPL23A/MRPL17/MRPS21/MRPL14/RPS15/RPL13A	37
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	22/3122	109/8144	1	1	0.665	CSNK2B/NHP2/RRP7A/NXT1/EIF6/REXO1/FCF1/NOB1/TBL3/NXF1/NAT10/GAR1/PWP2/NMD3/XPO1/POP5/SBDS/TCOF1/BMS1/POP7/IMP4/FBLL1	22
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	9/3122	66/8144	1	1	0.665	LARS2/PARS2/TARS2/VARS2/FARS2/FARSA/IARS2/CARS2/AARS2	9
KEGG	hsa04613	Neutrophil extracellular trap formation	41/3122	190/8144	1	1	0.665	ITGA2B/SYK/SLC25A31/PLCB3/PIK3R3/RELA/HDAC5/PLCG2/CLCN5/AGER/PADI4/MAP2K2/MTOR/MAP2K1/MAPK11/SRC/AKT1/VWF/PLCB2/ITGB3/AKT2/HDAC4/GP1BA/CR1L/NCF1/CYBA/ITGAL/MAPK12/HDAC11/PIK3CA/AKT3/PIK3R2/CASP1/PRKCA/RAC1/HDAC7/PRKCB/RAF1/HDAC6/FCGR3A/CAMP	41
KEGG	hsa05168	Herpes simplex virus 1 infection	131/3122	495/8144	1	1	0.665	TP53/IRF9/SYK/ZNF114/TLR9/ZNF777/ZNF317/ZNF735/TICAM1/CARD9/ZNF700/ZNF783/ZNF597/ZNF778/ZNF141/ZNF716/PIK3R3/TYK2/ZNF282/IFNA14/RELA/ZNF398/BAK1/TSC2/TSC1/IKBKB/ZNF195/ZNF205/ZNF627/ZNF547/IRF7/POU2F2/MTOR/ZNF251/ZNF761/ZNF780A/HLA-G/ZFP57/ZNF613/SRC/ZNF324/ZNF225/BAD/AKT1/ZNF517/PILRA/ZNF589/ZNF3/ITGB3/TRADD/POU2F3/PPP1CA/ZNF684/IRF3/AKT2/ZNF675/CASP8/ZNF133/TAPBP/DAXX/ZNF226/ZNF679/ZNF785/STAT2/TLR3/NXF1/ZNF98/TRAF2/IFNA13/ZNF227/HLA-F/EIF2AK1/ZNF584/ZNF30/ZIM3/ZNF705A/ZNF786/ZNF211/ZNF20/ZNF74/RHEB/PIK3CA/TRAF6/AKT3/ZNF284/EIF2B3/PIK3R2/OAS1/ZNF557/CCL2/ZNF155/ZNF662/IL1B/ZNF169/ZNF320/ZNF768/ZNF721/PML/ZNF416/ZNF436/ZNF41/ZNF853/ZFP30/HCFC1/IFNAR1/ZNF331/TAP1/IFIH1/ZNF324B/ZNF566/ZNF670/ZNF792/CD74/SP100/ZNF540/EIF2B5/BST2/ZNF79/TAP2/ZNF404/ZNF273/ZNF527/ZNF184/ZNF44/BCL2/FAS/ZNF460/ZNF836/ZNF90/ZNF846/ZNF34	131
KEGG	hsa05322	Systemic lupus erythematosus	16/3122	136/8144	1	1	0.665	ACTN4/C1R/C1QA/ACTN1/C1QC/GRIN2B/IL10/CD28/C1QB/C7/GRIN2A/C2/C4A/C4B/CD40/FCGR3A	16
KEGG	hsa04740	Olfactory transduction	62/3122	440/8144	1	1	0.665	ARRB1/PDE2A/PRKACA/OR7C2/CAMK2A/CNGB1/GUCY2D/OR5I1/OR14A16/CNGA3/OR10Q1/OR10G7/OR10K2/PRKACB/SLC8A2/GNAL/OR2V2/CALML4/CAMK2G/PDE1B/OR5R1/OR5A2/OR5T2/OR2C1/OR10H4/OR2A25/ANO2/OR52I2/OR4K1/OR4D5/ADCY3/OR4C46/OR10X1/OR5H14/OR8J1/OR4C15/CALML6/OR7G2/CAMK2B/OR52W1/CALML5/CALM3/CNGA4/CAMK2D/OR10T2/OR6B2/OR4C16/OR1K1/PDE1C/OR8K1/OR5H1/OR2AG2/OR11L1/OR4A15/OR1A1/OR5P2/GNG13/OR1M1/OR5B17/OR6T1/OR11A1/OR52B6	62