ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05168	Herpes simplex virus 1 infection	264/3289	495/8135	1.523e-09	5.088e-07	4.378e-07	ZNF585A/ZNF184/ZNF420/ZNF585B/ZNF570/IFIH1/ZNF222/ZNF33B/ZNF189/HCFC2/ZNF227/ZNF44/ZNF223/ZNF680/ZNF160/ZNF404/ZNF605/BIRC3/SRPK1/ZNF566/DDX58/HLA-DMB/IFNGR1/ZNF224/ZNF14/ZNF568/CASP3/ZNF235/ZNF354A/ZNF709/ZNF10/ZNF347/ZNF765/ZNF221/MAP3K7/ZNF721/ZNF613/ZNF431/BIRC2/ZNF567/ZNF460/ZNF383/ZNF433/ZNF816/ZNF761/ZNF285/ZNF354B/ZNF845/EIF2AK2/ZNF813/ZNF565/ZNF302/ZNF805/ZNF561/ZNF684/ZNF611/PIK3CA/ZNF208/ZNF84/ZNF98/ZNF432/CHUK/ZNF141/JAK2/ZNF814/ZNF846/TLR2/ZNF26/ZNF836/ZNF544/ZNF268/PPP1CB/ZNF850/ZFP37/ZNF700/ZNF563/ZNF682/ZFP82/TBK1/ZNF891/HLA-DRA/FAS/SP100/ZNF320/ZNF468/PIK3CB/PPP1CC/SRSF7/ZNF45/ZNF440/HLA-DMA/EIF4EBP1/OAS1/ZNF23/EIF2B2/ZNF107/ZNF33A/ZNF492/ZNF85/TRAF5/ZNF708/BCL2/ZNF546/ZNF583/TAB2/PIK3R1/ZNF615/ZNF729/ZNF782/ZNF569/ZNF136/ZNF132/ZNF674/ZNF439/IRAK4/ZNF100/ZNF714/C3/CD74/ZNF311/ZNF135/ZNF808/ZNF737/ZNF596/ZNF791/EIF2S1/ZNF484/ZNF43/AKT3/NECTIN2/ZNF415/HCFC1/PIK3R3/HLA-DOA/ZNF562/ZNF140/ZNF417/ZNF430/ZNF841/ZNF101/IKBKB/IFNAR1/HLA-DQA1/ZNF479/ZNF234/ZNF510/ZNF253/ZNF878/HLA-DQA2/TAP2/NXF3/ZNF679/ZNF37A/TAPBP/SRSF4/ZNF426/ZNF81/CASP9/ZNF181/ZNF614/OAS2/ZFP30/SRSF8/CARD9/ZNF689/ZNF552/ZNF506/ZNF736/ZNF200/ZNF749/ZNF514/ZNF675/TLR3/ZNF571/ZNF564/ZNF528/EIF2B1/ZNF773/ZNF429/TP53/ZFP14/ZNF254/ZNF331/TNF/ZNF763/ZNF286A/SOCS3/AKT2/PIK3CD/ZNF829/STAT1/ZNF257/ZIK1/EIF2B5/ZNF416/ZFP69/MYD88/HLA-DPA1/ZNF778/SRSF1/ZNF205/ZNF584/ZNF662/ZNF670/ZNF443/IFNB1/CCL2/ZNF212/ZNF490/POU2F1/PILRB/ZFP1/HLA-DQB1/RBAK/ZNF540/ZNF879/ZNF382/TYK2/ZNF25/ZNF34/ZNF273/ZNF768/ZNF578/ZNF799/TAB1/ZNF169/ZNF233/ZNF600/ZNF8/ZNF875/ZNF398/DAXX/ZNF547/SRSF2/BAK1/ZNF354C/ZNF665/ZNF555/ZNF133/ZNF441/ZNF30/SRSF3/PML/ZNF676/AKT1/PTPN11/PILRA/ZNF180/ZNF707/ALYREF/ZNF599/ZNF7/ZNF669/ZNF112/ZNF124/ZNF471/ZNF786/EIF2B3/IFNA21/ZNF317/ZNF57/ZNF519/ZNF90/ZNF630	264
KEGG	hsa03013	Nucleocytoplasmic transport	68/3289	108/8135	1.649e-06	0.0002147	0.0001847	NUP88/CSE1L/NUP133/NUP107/PNN/NUP160/NUP153/THOC2/NUP35/SUMO1/NUP54/NXT2/AHCTF1/PHAX/XPOT/TNPO1/NUP155/RANBP2/NCBP1/KPNA5/TPR/XPO1/UPF3B/NMD3/NUP98/NUP205/SRRM1/NUP43/NUP58/DDX19B/UPF3A/KPNA3/DDX19A/NUP50/NUP93/NUP37/NXF3/IPO11/THOC6/SEH1L/SNUPN/NUP62/MAGOHB/NUP188/MAGOH/XPO7/RANGAP1/KPNA6/IPO7/TNPO2/NXT1/SUMO2/KPNA2/TMEM33/IPO13/POM121/RAN/NUP42/ALYREF/SENP2/SAP18/KPNB1/THOC3/THOC5/IPO9/AAAS/SUMO3/UPF1	68
KEGG	hsa04120	Ubiquitin mediated proteolysis	85/3289	142/8135	1.928e-06	0.0002147	0.0001847	ANAPC4/HERC4/CUL4B/UBA3/SMURF2/BIRC3/UBE2Q2/BIRC2/RHOBTB1/CUL3/UBA2/UBR5/FANCL/CUL5/CDC16/ANAPC13/ITCH/CUL2/CUL1/UBA6/RCHY1/CDC27/TRIM37/ANAPC16/XIAP/PIAS2/HERC3/UBE2B/SKP1/ANAPC11/CUL4A/UBE2J1/UBE2G2/CDC26/FBXW7/MDM2/UBE2D4/NEDD4/COP1/UBE2E2/UBE2L6/ELOC/ELOB/MAP3K1/SKP2/FZR1/NHLRC1/ANAPC15/KLHL9/ANAPC10/UBE2O/UBE2H/SOCS3/UBE3A/UBE4A/PIAS3/UBE2D1/SAE1/UBE2K/BIRC7/UBE2J2/WWP1/UBE2M/CBLB/UBE2W/RNF7/DDB1/PML/UBE4B/UBA1/BIRC6/HERC1/HERC2/SMURF1/RPS27A/UBE2Z/PRPF19/CDC34/UBE2C/UBE2R2/BRCA1/FBXW8/KEAP1/UBE2A/UBE2E1	85
KEGG	hsa04110	Cell cycle	75/3289	126/8135	1.02e-05	0.000852	0.0007331	ANAPC4/RBL1/ORC3/CCND1/STAG2/HDAC2/CDC7/DBF4/SMAD4/ATM/RBL2/SMC3/CCNE2/RAD21/RB1/BUB1/CDK1/CDC16/ANAPC13/PRKDC/TTK/ATR/ORC2/STAG1/MAD2L1/CUL1/CDKN1C/YWHAZ/TGFB2/CDC14B/CDC27/ANAPC16/CDC45/ORC4/MAD2L2/CDK7/SMAD2/SKP1/CDC6/ANAPC11/YWHAB/CDC26/MDM2/CCNB2/CHEK2/EP300/PTTG2/SKP2/BUB1B/FZR1/ANAPC15/CDKN2C/CDK4/ANAPC10/TP53/GADD45B/GSK3B/PKMYT1/CCND2/SMAD3/MCM6/CDK6/CDC14A/CHEK1/TGFB1/PLK1/TFDP2/CCNE1/CDKN1B/CCNA1/CDKN2A/E2F3/MCM3/SMC1A/E2F2	75
KEGG	hsa03460	Fanconi anemia pathway	37/3289	54/8135	2.647e-05	0.001768	0.001522	RPA4/PMS2/POLI/REV1/FANCM/PALB2/RAD51C/FANCL/REV3L/RMI1/FANCI/ATR/FANCD2/WDR48/USP1/FAAP24/POLK/BLM/FAAP100/RAD51/ERCC4/CENPX/EME1/FANCA/TOP3B/RPA1/ATRIP/ERCC1/POLH/MLH1/FAN1/RPA2/HES1/FANCB/BRCA2/BRCA1/POLN	37
KEGG	hsa04144	Endocytosis	132/3289	251/8135	5.131e-05	0.002856	0.002457	SNX2/SNX4/RABEP1/VPS36/SMURF2/PRKCI/SNX6/VPS26A/EPS15/CAPZA2/RAB11FIP2/ASAP1/KIF5B/VTA1/RAB11A/ACTR3/STAM2/ACTR2/AGAP5/EEA1/ITCH/WASHC4/WASHC5/RAB4A/ARFGEF1/AGAP9/SH3GL3/ARFGEF2/CAPZA1/VPS35/PLD1/RUFY2/RAB5A/GRK6/VPS28/VPS4B/AGAP4/AGAP2/CDC42/CHMP5/CHMP2B/VPS45/SMAD2/EPN1/TFRC/SNX3/GIT2/SNX5/HSPA6/MDM2/PDGFRA/RAB11FIP4/RAB31/VPS25/NEDD4/SH3GLB1/ZFYVE16/ARPC3/ARPC4/EPN3/ARAP3/ARPC1A/PDCD6IP/GRK1/HSPA1L/ARAP1/AGAP6/ARFGAP2/ACTR3C/IQSEC3/RAB5C/PARD6B/AGAP1/VPS26B/WIPF2/ARFGAP1/WASHC3/PRKCZ/VPS29/ARF5/IL2RG/ACTR3B/USP8/GRK5/RAB8A/RNF41/PARD6A/SMAD3/AP2S1/ASAP3/DNM1/CHMP4C/ARPC2/SNX12/RAB7A/MVB12A/PIP5K1C/VPS37A/RAB11B/HGS/DNAJC6/CYTH1/CXCR2/RAB10/SH3GL2/RAB5B/WWP1/RAB11FIP1/CXCR1/STAM/CBLB/ARPC5/FOLR3/RAB35/PML/GRK4/CYTH2/HRAS/AP2A2/CHMP3/AP2M1/DNM2/ACAP2/CLTB/SMURF1/SNX32/ARPC5L/CHMP1A/DNM3/CAV1/LDLR/HSPA1B	132
KEGG	hsa00900	Terpenoid backbone biosynthesis	18/3289	22/8135	8.712e-05	0.004157	0.003577	GGPS1/NUS1/PCYOX1/HMGCR/IDI1/HMGCS1/ZMPSTE24/FNTA/ICMT/ACAT1/MVD/DHDDS/PDSS1/FNTB/RCE1/ACAT2/FDPS/PMVK	18
KEGG	hsa00062	Fatty acid elongation	20/3289	27/8135	0.0004022	0.01679	0.01445	HSD17B12/ELOVL5/ELOVL6/ACOT4/HACD3/MECR/HADHA/ELOVL7/ACOT2/HACD1/THEM5/HADH/TECR/ELOVL2/THEM4/ACOT1/ELOVL3/HADHB/ELOVL1/ACAA2	20
KEGG	hsa03050	Proteasome	30/3289	46/8135	0.0005768	0.0214	0.01842	PSME4/PSMC6/PSMC1/PSMA3/PSMD12/PSMA2/PSMD6/PSMB2/PSMA4/PSMD1/PSMB5/PSMD7/PSMC2/PSMD14/PSMB10/PSMC3/PSME1/ADRM1/PSME3/PSMC4/PSMA8/PSMA7/PSMB11/PSMD2/PSMD13/PSMB9/PSMA6/PSMD9/PSMB7/PSMD8	30
KEGG	hsa01212	Fatty acid metabolism	35/3289	57/8135	0.001076	0.03594	0.03092	SCP2/ACADM/CBR4/ACSL3/HSD17B12/ELOVL5/HSD17B4/ACSL4/ELOVL6/ACOX3/ACSL5/FADS1/HACD3/ACAT1/HSD17B8/MCAT/MECR/ACADSB/CPT1C/ACSL1/HADHA/CPT1A/ELOVL7/HACD1/HADH/SCD/TECR/ELOVL2/ACAT2/HTD2/ELOVL3/HADHB/ELOVL1/ACAA2/FADS2	35
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	19/3289	27/8135	0.001571	0.04769	0.04103	SCP2/HSD17B12/ELOVL5/HSD17B4/ELOVL6/ACOT4/ACOX3/FADS1/HACD3/ELOVL7/ACOT2/HACD1/SCD/TECR/ELOVL2/ACOT1/ELOVL3/ELOVL1/FADS2	19
KEGG	hsa05014	Amyotrophic lateral sclerosis	173/3289	364/8135	0.002967	0.07599	0.06538	NUP88/NUP133/PIK3R4/NDUFS1/NUP107/SETX/NUP160/MATR3/CASP3/NUP153/PSMC6/NUP35/NDUFA5/NUP54/DCTN4/FIG4/CASP1/NXT2/ATG2B/OPTN/PSMC1/PSMA3/COX7A2/SPG11/KIF5B/PSMD12/SDHC/NUP155/TBK1/RANBP2/PPP3R1/PIK3C3/SRSF7/NCBP1/TPR/NDUFC1/BCL2/RAB5A/NUP98/PSMA2/RAB1A/NDUFA9/ALS2/NUP205/PSMD6/HNRNPA2B1/NUP43/PSMB2/PSMA4/NUP58/EIF2S1/CHMP2B/COX6B1/WDR41/RAB39B/SOD1/C9orf72/DNAH14/COX4I2/MAP2K6/UQCR10/PSMD1/PPP3CC/VDAC1/PSMB5/PSMD7/KLC3/NUP50/PSMC2/COX8A/COX6B2/NUP93/NUP37/NDUFB3/DNAH7/TUBB/NDUFS7/NXF3/ATG101/DCTN6/MAP1LC3B/CASP9/CYC1/SEH1L/PSMD14/UQCRB/TOMM40/TANK/ATF6/NUP62/GPX3/NDUFA11/VAPB/GPX1/PSMC3/COX5A/NUP188/NDUFA13/MCU/TP53/ULK1/ATP5MC1/NDUFB6/TNF/RAB8A/UQCR11/NDUFV2/UQCRC2/COX6C/ADRM1/PSMC4/COX5B/TUBB4B/NDUFS4/DNAH3/NDUFB5/UQCRQ/PSMA8/PSMA7/TUBB8/GRIA1/GPX7/ACTR1B/DNAH1/NDUFV3/DNAH8/NXT1/COX7A2L/PSMD2/GPX6/NRBF2/NDUFA2/COX7A1/DCTN3/WIPI2/RB1CC1/UQCRC1/PSMD13/GPX2/COX4I1/HNRNPA1/ACTG1/NDUFC2-KCTD14/POM121/DAXX/PSMA6/ATP5MC2/ATP5PB/PSMD9/DNAI1/ATP5MC3/ACTR10/NDUFB2/PSMB7/SRSF3/ULK2/NDUFAB1/ATXN2L/ALYREF/DNAH10/ATG13/UQCRH/UQCRHL/TNFRSF1B/ATP5PF/GRIN2B/PSMD8/ANG/COX7B/NDUFS8/ATP5F1D/DCTN5/DCTN2	173
KEGG	hsa05220	Chronic myeloid leukemia	43/3289	76/8135	0.003106	0.07599	0.06538	CCND1/HDAC2/SMAD4/PIK3CA/CHUK/RB1/PIK3CB/SOS2/RUNX1/PIK3R1/TGFB2/POLK/AKT3/PIK3R3/SHC4/IKBKB/MDM2/GRB2/STAT5B/NRAS/MAP2K1/SOS1/CRKL/CDK4/TP53/GADD45B/AKT2/PIK3CD/SMAD3/CTBP1/CDK6/KRAS/TGFB1/BAK1/AKT1/PTPN11/HRAS/STAT5A/GAB2/CDKN1B/CDKN2A/E2F3/E2F2	43
KEGG	hsa05223	Non-small cell lung cancer	41/3289	72/8135	0.003272	0.07599	0.06538	EGF/CCND1/PIK3CA/KIF5B/RB1/PIK3CB/SOS2/FOXO3/PIK3R1/POLK/STK4/EML4/AKT3/PIK3R3/GRB2/RXRA/STAT5B/CASP9/NRAS/MAP2K1/PDPK1/SOS1/CDK4/TP53/GADD45B/AKT2/PIK3CD/RASSF1/RET/JAK3/CDK6/KRAS/BAK1/AKT1/HRAS/STAT5A/PRKCB/CDKN2A/E2F3/E2F2/MET	41
KEGG	hsa03040	Spliceosome	76/3289	147/8135	0.003449	0.07599	0.06538	PRPF18/DDX46/SYF2/DHX15/TRA2B/SF3B1/CRNKL1/SLU7/THOC2/AQR/SRSF10/CDC5L/PRPF38B/TRA2A/SNW1/TCERG1/RBM25/DDX5/PPIH/SRSF7/NCBP1/U2SURP/PLRG1/SNRPB2/PRPF4/HNRNPU/CDC40/HSPA6/PQBP1/CWC15/SNRPD1/SRSF4/HSPA1L/SNRPC/WBP11/SF3B4/SRSF8/DHX8/SNRPE/PPIE/HNRNPK/PCBP1/SNRNP40/MAGOHB/SNRNP27/LSM5/MAGOH/SNRPA1/PRPF38A/SRSF1/PRPF31/SF3B6/SF3A2/PRPF40B/LSM4/SNU13/PRPF3/RBM22/BCAS2/HNRNPA1/RBM17/LSM6/SRSF2/ISY1/XAB2/SNRNP200/EFTUD2/SRSF3/SF3B3/ALYREF/PHF5A/THOC3/PRPF19/CTNNBL1/DDX42/HSPA1B	76
KEGG	hsa04218	Cellular senescence	80/3289	156/8135	0.00364	0.07599	0.06538	TRPM7/RBL1/CCND1/ITPR2/MRE11/HIPK3/ATM/PIK3CA/RBL2/CCNE2/TRAF3IP2/RB1/CDK1/PPP1CB/PPP3R1/PIK3CB/PPP1CC/RAD1/NBN/PTEN/ATR/EIF4EBP1/MAPKAPK2/FOXO3/PIK3R1/TGFB2/SIRT1/NFATC3/SLC25A4/SMAD2/AKT3/CALM3/MRAS/MAP2K6/PIK3R3/KIR2DL4/PPP3CC/MDM2/HIPK1/VDAC1/NFATC4/NRAS/MAP2K1/RRAS/CCNB2/CHEK2/ZFP36L1/CDK4/MCU/LIN54/TP53/GADD45B/FOXO1/AKT2/PIK3CD/CCND2/LIN37/SMAD3/ITPR1/CALM1/FOXM1/HIPK2/LIN9/CDK6/KRAS/ETS1/CHEK1/HUS1/CXCL8/TGFB1/SLC25A6/NFATC2/AKT1/HRAS/IGFBP3/CCNE1/CCNA1/CDKN2A/E2F3/E2F2	80
KEGG	hsa05100	Bacterial invasion of epithelial cells	43/3289	77/8135	0.004317	0.08482	0.07298	SEPTIN11/ITGB1/FN1/PIK3CA/ACTR3/ACTR2/PIK3CB/SEPTIN6/PIK3R1/CD2AP/MAD2L2/CDC42/PIK3R3/SHC4/WASF1/ARPC3/ARPC4/ARPC1A/RHOG/ACTR3C/ILK/SEPTIN3/ELMO2/CRKL/ARHGEF26/ACTR3B/PIK3CD/DNM1/ARPC2/SEPTIN2/SEPTIN9/ACTG1/PXN/GAB1/ARPC5/DNM2/CLTB/CTTN/ARPC5L/DNM3/MET/CAV1/BCAR1	43
KEGG	hsa04115	p53 signaling pathway	41/3289	73/8135	0.004586	0.08509	0.07321	CCNG1/CASP3/CCND1/ATM/CCNE2/CDK1/FAS/PTEN/ATR/RRM2B/MDM4/BCL2/RCHY1/SIVA1/PERP/MDM2/EI24/COP1/SESN3/CASP9/THBS1/GORAB/CCNB2/CHEK2/CDK4/TP53/PPM1D/GADD45B/CCND2/SESN1/CDK6/TP53I3/TP73/CHEK1/GTSE1/IGFBP3/STEAP3/SESN2/CCNE1/CDKN2A/TNFRSF10A	41
KEGG	hsa04146	Peroxisome	45/3289	82/8135	0.005514	0.09694	0.0834	ABCD3/SCP2/PEX1/PEX3/ACSL3/SLC27A2/ABCD2/DHRS4/HSD17B4/ACSL4/PEX2/CROT/GNPAT/ACOX3/ACSL5/AGPS/XDH/PEX11B/SOD1/HACL1/CRAT/FAR1/ACSL1/IDH1/MPV17/MPV17L2/PEX5L/GSTK1/PEX6/PAOX/PEX10/NUDT7/ACOT8/MPV17L/SLC25A17/PRDX5/HMGCL/PEX14/PMVK/PXMP4/PXMP2/ECH1/HAO2/DECR2/AMACR	45
KEGG	hsa04130	SNARE interactions in vesicular transport	21/3289	33/8135	0.005899	0.0983	0.08457	VAMP7/STX17/YKT6/VAMP4/STX2/STX7/BET1/GOSR2/STX11/VTI1A/BNIP1/USE1/GOSR1/STX4/BET1L/STX16/STX18/VAMP5/VAMP8/VTI1B/STX1B	21
KEGG	hsa03440	Homologous recombination	25/3289	41/8135	0.00618	0.0983	0.08457	BARD1/RPA4/TOPBP1/MRE11/RAD54B/ATM/ABRAXAS1/PALB2/RAD51C/NBN/SYCP3/RBBP8/UIMC1/BLM/BABAM2/RAD51/EME1/TOP3B/RPA1/BRCC3/POLD2/RPA2/BRCA2/RAD51B/BRCA1	25
KEGG	hsa05213	Endometrial cancer	33/3289	58/8135	0.008057	0.1165	0.1003	EGF/CCND1/PIK3CA/AXIN2/PIK3CB/SOS2/PTEN/FOXO3/APC/PIK3R1/POLK/AKT3/PIK3R3/AXIN1/GRB2/CASP9/NRAS/MAP2K1/PDPK1/ILK/SOS1/TCF7/TP53/GADD45B/AKT2/PIK3CD/GSK3B/KRAS/MLH1/BAK1/APC2/AKT1/HRAS	33
KEGG	hsa03450	Non-homologous end-joining	10/3289	13/8135	0.008472	0.1165	0.1003	MRE11/DCLRE1C/XRCC5/PRKDC/LIG4/XRCC4/NHEJ1/XRCC6/POLM/FEN1	10
KEGG	hsa05144	Malaria	29/3289	50/8135	0.00887	0.1165	0.1003	TLR2/KLRK1/TLR4/TGFB2/HBA1/HBA2/CSF3/ITGAL/CD40LG/THBS1/THBS4/CR1/KLRC4-KLRK1/TNF/SELP/CD40/MYD88/LRP1/GYPA/CCL2/KLRB1/CXCL8/TGFB1/VCAM1/ACKR1/HBB/PECAM1/ICAM1/MET	29
KEGG	hsa00280	Valine, leucine and isoleucine degradation	28/3289	48/8135	0.009048	0.1165	0.1003	HIBCH/ACADM/DLD/AUH/OXCT1/HMGCS1/MCEE/DBT/BCAT2/IL4I1/ACAT1/ACADSB/ALDH6A1/HSD17B10/PCCA/ABAT/HADHA/PCCB/IVD/HADH/BCKDHA/ACAD8/ACAT2/ALDH7A1/HMGCL/HADHB/ALDH2/ACAA2	28
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	19/3289	30/8135	0.009369	0.1165	0.1003	DLD/MCEE/ACAT1/GLDC/ACO2/PCCA/GRHPR/PCCB/AMT/PGP/ACSS1/ACAT2/ACO1/MDH1/SHMT1/GCSH/ACSS2/HAO2/MDH2	19
KEGG	hsa05211	Renal cell carcinoma	38/3289	69/8135	0.009545	0.1165	0.1003	PIK3CA/CUL2/PIK3CB/SOS2/HIF1A/PIK3R1/TGFB2/CDC42/AKT3/PIK3R3/RAP1A/GRB2/ELOC/ELOB/NRAS/MAP2K1/PRCC/PAK1/EP300/SOS1/CRKL/AKT2/PIK3CD/KRAS/ETS1/TGFB1/PAK6/GAB1/AKT1/PTPN11/HRAS/VEGFA/BUB1B-PAK6/ARNT/EPAS1/MET/ARNT2/PAK4	38
KEGG	hsa05017	Spinocerebellar ataxia	72/3289	143/8135	0.00977	0.1165	0.1003	PIK3R4/PSMC6/ITPR2/ATG2B/PSMC1/PSMA3/PIK3CA/OMA1/OPA1/PSMD12/PIK3CB/PIK3C3/ATXN3/PIK3R1/PSMA2/PSMD6/SLC25A4/PSMB2/PSMA4/KCND3/TWNK/AKT3/PIK3R3/ATXN1/PSMD1/VDAC1/PSMB5/PSMD7/PLCB1/PSMC2/GNAQ/ATG101/PSMD14/PSMC3/MAPK9/CIC/MCU/ULK1/AKT2/PIK3CD/ADRM1/ITPR1/PSMC4/PPIF/PSMA8/PSMA7/GRIA1/PUM2/PSMD2/SPTBN2/KAT5/ATXN10/NRBF2/PUM1/WIPI2/RB1CC1/PSMD13/PLCB2/PLCB4/SLC25A6/PSMA6/PSMD9/PSMB7/ULK2/AKT1/ATXN2L/KCNC3/ATG13/GRIN3B/PRKCB/GRIN2B/PSMD8	72
KEGG	hsa04140	Autophagy - animal	71/3289	141/8135	0.01021	0.1176	0.1012	PIK3R4/PRKAA1/ATG4C/MAP3K7/SUPT20H/ATG2B/HMGB1/PIK3CA/RRAGB/STX17/TBK1/PIK3CB/PIK3C3/PTEN/PRKCQ/HIF1A/RRAGC/BCL2/PIK3R1/PRKACB/RAB1A/VMP1/GABARAP/ATG3/EIF2S1/WDR41/RAB39B/C9orf72/AKT3/MRAS/PIK3R3/ZFYVE1/CFLAR/DAPK1/SH3GLB1/ATG10/ATG101/MAP1LC3B/NRAS/MAP2K1/PDPK1/TANK/RRAS/UVRAG/MAPK9/ULK1/ATG7/PPP2CA/ATG12/AKT2/PIK3CD/PRAP1/RAB8A/ITPR1/CTSD/DAPK2/KRAS/ATG4B/RAB7A/DDIT4/NRBF2/WIPI2/RB1CC1/VAMP8/ULK2/AKT1/RRAGD/HRAS/ATG13/CTSL/RAB33B	71
KEGG	hsa05169	Epstein-Barr virus infection	98/3289	202/8135	0.01119	0.1235	0.1062	DDX58/HLA-DMB/CASP3/PSMC6/MAP3K7/CCND1/HDAC2/CIR1/EIF2AK2/PSMC1/PIK3CA/CCNE2/CHUK/PSMD12/SNW1/RB1/TLR2/TBK1/HLA-DRA/FAS/PIK3CB/HLA-DMA/CD44/OAS1/TRAF5/BCL2/TAB2/PIK3R1/CD58/PSMD6/IRAK4/POLK/AKT3/MAP2K6/PIK3R3/HLA-DOA/PSMD1/IKBKB/MDM2/IFNAR1/HLA-DQA1/ITGAL/NEDD4/NFKBIE/PSMD7/PSMC2/HLA-DQA2/TAP2/TAPBP/FCER2/CASP9/PSMD14/OAS2/USP7/SKP2/PSMC3/MAPK9/CDK4/TP53/LYN/BLNK/GADD45B/TNF/NCOR2/AKT2/PIK3CD/STAT1/CCND2/CD40/ADRM1/PSMC4/MYD88/HLA-DPA1/JAK3/CDK6/IFNB1/RUNX3/PSMD2/HLA-DQB1/ENTPD8/TYK2/HES1/PSMD13/TAB1/BAK1/RELB/AKT1/CD3E/BCL2L11/RIPK1/IFNA21/CCNE1/CDKN1B/CCNA1/E2F3/ICAM1/PSMD8/E2F2	98
KEGG	hsa05212	Pancreatic cancer	41/3289	76/8135	0.01146	0.1235	0.1062	EGF/CCND1/SMAD4/PIK3CA/CHUK/RB1/PIK3CB/PLD1/PIK3R1/TGFB2/RAC2/POLK/ARHGEF6/CDC42/SMAD2/AKT3/PIK3R3/IKBKB/RALBP1/CASP9/MAP2K1/RAD51/MAPK9/CDK4/TP53/GADD45B/AKT2/PIK3CD/STAT1/SMAD3/CDK6/KRAS/RAC3/TGFB1/BAK1/AKT1/VEGFA/BRCA2/CDKN2A/E2F3/E2F2	41
KEGG	hsa04141	Protein processing in endoplasmic reticulum	84/3289	171/8135	0.01232	0.1286	0.1106	HSPH1/PLAA/SVIP/EDEM3/UGGT1/SAR1B/NGLY1/DNAJC10/EIF2AK2/SEC24B/HSP90B1/UBXN4/SEC23A/DNAJA1/SEC31B/SEC63/SEL1L/YOD1/ERO1A/STT3B/CUL1/BCL2/UBXN8/BAG2/ATXN3/MAN1A1/SSR1/UGGT2/SEC31A/CRYAA/CRYAA2/LMAN1/RAD23B/SEC61A1/SEC61A2/EIF2S1/TRAM1/SKP1/UBE2J1/MAN1A2/UBE2G2/HYOU1/HSPBP1/HSPA6/UBE2D4/DNAJB1/HERPUD1/CKAP4/HSPA1L/ERLEC1/ATF6/LMAN2/SSR2/DNAJC1/FBXO6/DNAJB11/MAPK9/DNAJB12/SELENOS/MAN1C1/UBE2D1/RNF5/TRAM1L1/NFE2L2/UBXN6/RPN1/NPLOC4/SEC24A/UBE2J2/PRKCSH/AMFR/SEC23B/BAK1/RNF185/ERP29/UBE4B/EDEM2/BCAP31/DERL2/CANX/SEL1L2/HSPA1B/DNAJC5/STT3A	84
KEGG	hsa05016	Huntington disease	143/3289	306/8135	0.01325	0.1316	0.1133	PIK3R4/NDUFS1/TFAM/CASP3/PSMC6/NDUFA5/DCTN4/HDAC2/ATG2B/PSMC1/PSMA3/COX7A2/KIF5B/PSMD12/SDHC/POLR2B/PIK3C3/NDUFC1/CREB1/PSMA2/NDUFA9/PSMD6/SLC25A4/PSMB2/PSMA4/COX6B1/SOD1/DNAH14/COX4I2/UQCR10/PSMD1/VDAC1/REST/PSMB5/PSMD7/KLC3/PLCB1/POLR2C/PSMC2/COX8A/COX6B2/CREB3L4/GNAQ/NDUFB3/DNAH7/TUBB/NDUFS7/ATG101/DCTN6/CASP9/CYC1/PSMD14/UQCRB/EP300/GPX3/NDUFA11/GRIA4/CREB5/GPX1/PSMC3/COX5A/RCOR1/MAPK9/NDUFA13/TP53/ULK1/ATP5MC1/NDUFB6/KCNJ10/POLR2J3/UQCR11/NDUFV2/UQCRC2/COX6C/ADRM1/ITPR1/AP2S1/PSMC4/COX5B/TUBB4B/PPIF/NDUFS4/DNAH3/CREB3/NDUFB5/UQCRQ/PSMA8/PSMA7/TUBB8/GRIA1/GPX7/ACTR1B/POLR2D/DNAH1/NDUFV3/DNAH8/POLR2G/COX7A2L/PSMD2/GPX6/NRBF2/NDUFA2/COX7A1/DCTN3/WIPI2/RB1CC1/UQCRC1/PSMD13/GPX2/COX4I1/NDUFC2-KCTD14/PLCB2/PLCB4/SLC25A6/PSMA6/ATP5MC2/ATP5PB/PSMD9/DNAI1/ATP5MC3/ACTR10/NDUFB2/PSMB7/ULK2/NDUFAB1/AP2A2/CREB3L1/DNAH10/ATG13/AP2M1/UQCRH/UQCRHL/TAF4B/CLTB/ATP5PF/GRIN2B/PSMD8/TGM2/COX7B/NDUFS8/ATP5F1D/DCTN5/DCTN2	143
KEGG	hsa03420	Nucleotide excision repair	27/3289	47/8135	0.01343	0.1316	0.1133	GTF2H2/CUL4B/ERCC6/RPA4/GTF2H2C/MNAT1/BIVM-ERCC5/ERCC5/RFC1/XPA/GTF2H1/POLE2/RFC2/RAD23B/CDK7/CETN2/CUL4A/RFC3/RFC5/ERCC4/RPA1/ERCC1/POLD2/RPA2/XPC/DDB1/GTF2H4	27
KEGG	hsa05132	Salmonella infection	118/3289	249/8135	0.01409	0.1316	0.1133	CSE1L/VPS41/MYLPF/BIRC3/CASP3/MAP3K7/DCTN4/BIRC2/CASP1/PIK3CA/TNFSF10/HSP90B1/KIF5B/CHUK/TLR2/DYNC1LI1/ACTR3/ACTR2/NCKAP1/MYL5/PIK3CB/PIK3C3/DYNC2LI1/TLR4/EXOC5/BCL2/RAB5A/TAB2/LY96/IRAK4/GCC2/MYL12A/CDC42/MYO6/TXN2/ROCK2/SKP1/AKT3/FLNC/KPNA3/MAP2K6/VPS18/ABI1/PIK3C2A/IKBKB/RHOB/TXN/ARPC3/KLC3/ARPC4/TLR5/TUBB/ARPC1A/DCTN6/RHOG/ACTR3C/MAP2K1/RRAS/WASF3/NAIP/RAB5C/SNX33/CASP4/PAK1/PTPRC/ELMO2/PLEKHM1/TCF7/MAPK9/ARHGEF26/ACTR3B/TNF/AKT2/PIK3CD/PYCARD/RIPK2/ARL8B/FLNB/TUBB4B/MYD88/ARPC2/ACBD3/TUBB8/CASP5/ACTR1B/RAB7A/ANXA2/DYNLT3/DCTN3/CXCL8/CYTH1/TAB1/RAB5B/ACTG1/RILP/ARL8A/DYNLL2/BAK1/ARPC5/VPS11/ACTR10/NCKAP1L/AKT1/CYTH2/HRAS/RIPK1/DNM2/TAB3/DYNLRB2/TLR6/MYL12B/ARPC5L/AHNAK/PODXL/MYL9/DCTN5/TNFRSF10A/DCTN2	118
KEGG	hsa03060	Protein export	15/3289	23/8135	0.0142	0.1316	0.1133	SRP54/SRP9/SRP72/SEC63/SPCS1/SEC61A1/SEC61A2/SEC11A/SRPRB/IMMP1L/SRP68/OXA1L/SRP19/SRPRA/SEC11C	15
KEGG	hsa00190	Oxidative phosphorylation	67/3289	134/8135	0.01493	0.1316	0.1133	NDUFS1/ATP6V1C1/NDUFA5/COX7A2/SDHC/ATP6V1H/NDUFC1/NDUFA9/COX17/ATP6V1A/PPA1/COX11/COX6B1/COX4I2/UQCR10/COX8A/COX6B2/NDUFB3/NDUFS7/CYC1/UQCRB/ATP6V1G2/ATP6V0D1/ATP6V0A1/NDUFA11/ATP6V1G1/ATP6V1F/COX5A/ATP5MF/NDUFA13/ATP5MC1/NDUFB6/ATP6V0B/UQCR11/NDUFV2/UQCRC2/COX6C/COX5B/ATP6V1D/NDUFS4/NDUFB5/UQCRQ/ATP6V0A2/NDUFV3/ATP4A/COX7A2L/NDUFA2/COX7A1/UQCRC1/PPA2/COX4I1/NDUFC2-KCTD14/ATP6V1C2/ATP5MC2/ATP5PB/ATP5MC3/NDUFB2/NDUFAB1/ATP6V1B2/COX15/UQCRH/UQCRHL/ATP5PF/ATP6AP1/COX7B/NDUFS8/ATP5F1D	67
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	106/3289	222/8135	0.01498	0.1316	0.1133	ANAPC4/HLA-DMB/NFYB/CCND1/SMAD4/ATM/PIK3CA/CCNE2/CHUK/DLG1/RB1/CDC16/ANAPC13/HLA-DRA/PPP3R1/PIK3CB/PTEN/ATR/HLA-DMA/XPO1/MAD2L1/KAT2B/CREB1/PIK3R1/PRKACB/TGFB2/NFATC3/SLC25A4/CDC27/ANAPC16/XIAP/SMAD2/AKT3/ANAPC11/PIK3R3/HLA-DOA/PPP3CC/CDC26/IKBKB/HLA-DQA1/VDAC1/ITGAL/HLA-DQA2/CREB3L4/NFATC4/STAT5B/MAP3K1/NRAS/MAP2K1/CCNB2/CHEK2/EP300/PTTG2/SRF/BUB1B/CREB5/ANAPC15/CDKN2C/MAPK9/CDK4/ANAPC10/TP53/ADCY5/IL2RG/TNF/AKT2/PIK3CD/CCND2/SMAD3/CD40/HLA-DPA1/CREB3/JAK3/IL15RA/TCF3/KRAS/ETS1/TLN1/HLA-DQB1/CHEK1/KAT5/TGFB1/ADCY2/SLC25A6/TLN2/RAN/CRTC1/FDPS/NFATC2/RELB/AKT1/CD3E/HRAS/STAT5A/CREB3L1/CCNE1/ELK4/CCNA1/CDKN2A/ADCY3/IL1R2/E2F3/ICAM1/CANX/E2F2/IL15	106
KEGG	hsa05210	Colorectal cancer	45/3289	86/8135	0.01649	0.1372	0.118	EGF/CASP3/MSH6/CCND1/SMAD4/PIK3CA/AXIN2/MSH3/PIK3CB/SOS2/BCL2/APC/PIK3R1/TGFB2/RAC2/POLK/SMAD2/APPL1/AKT3/PIK3R3/AXIN1/GRB2/DCC/CASP9/NRAS/MAP2K1/SOS1/TCF7/MAPK9/TP53/GADD45B/AKT2/PIK3CD/GSK3B/SMAD3/KRAS/RAC3/MLH1/TGFB1/BAK1/APC2/AKT1/BCL2L11/HRAS/BIRC5	45
KEGG	hsa03015	mRNA surveillance pathway	50/3289	97/8135	0.01684	0.1372	0.118	PPP2R5E/PCF11/NUDT21/PNN/RNGTT/ETF1/CPSF3/CSTF2T/NXT2/CPSF2/SMG1/PPP2R5A/PPP1CB/HBS1L/PPP1CC/NCBP1/UPF3B/CSTF3/PAPOLG/SRRM1/PPP2R3C/RNMT/PPP2R1B/FIP1L1/DDX19B/UPF3A/DDX19A/PABPC4/NXF3/CLP1/PABPN1L/PABPN1/PPP2R3A/GSPT1/CPSF4/MAGOHB/PPP2CA/MAGOH/GSPT2/PPP2R2A/NXT1/CPSF4L/SMG7/PABPC3/PABPC1/ALYREF/SAP18/PABPC4L/DAZAP1/UPF1	50
KEGG	hsa05215	Prostate cancer	50/3289	97/8135	0.01684	0.1372	0.118	EGF/CCND1/PIK3CA/HSP90B1/CCNE2/CHUK/RB1/PIK3CB/SOS2/PTEN/ZEB1/BCL2/CREB1/PIK3R1/AKT3/PIK3R3/IKBKB/MDM2/PDGFRA/GRB2/PDGFA/CREB3L4/CASP9/NRAS/MAP2K1/PDPK1/EP300/SOS1/CREB5/TCF7/TP53/FOXO1/AKT2/PIK3CD/GSK3B/FGFR1/CREB3/KRAS/TMPRSS2/INSRR/PDGFRB/AKT1/HRAS/CREB3L1/CCNE1/CDKN1B/IL1R2/E2F3/GSTP1/E2F2	50
KEGG	hsa05164	Influenza A	83/3289	171/8135	0.01822	0.1433	0.1233	IFIH1/DDX58/HLA-DMB/IFNGR1/CASP3/CASP1/NXT2/EIF2AK2/PIK3CA/TNFSF10/CHUK/JAK2/RAB11A/TBK1/HLA-DRA/FAS/PIK3CB/HLA-DMA/KPNA5/OAS1/TLR4/XPO1/NUP98/PIK3R1/CALCOCO2/IRAK4/SLC25A4/EIF2S1/AKT3/PRSS3/PIK3R3/HLA-DOA/IKBKB/IFNAR1/HLA-DQA1/VDAC1/PRSS1/HLA-DQA2/DNAJB1/NXF3/CASP9/PABPN1L/OAS2/RSAD2/MAP2K1/PABPN1/EP300/TLR3/CPSF4/CDK4/TNF/SOCS3/AKT2/PIK3CD/PYCARD/STAT1/MYD88/HLA-DPA1/CDK6/KPNA6/TMPRSS2/NXT1/IFNB1/CCL2/HLA-DQB1/RAB11B/KPNA2/TYK2/CXCL8/ACTG1/CPSF4L/BAK1/SLC25A6/FDPS/PML/AKT1/PRKCB/IFNA21/ICAM1/HNRNPUL1/TPSB2/TRIM25/TNFRSF10A	83
KEGG	hsa00510	N-Glycan biosynthesis	28/3289	50/8135	0.01845	0.1433	0.1233	MAN2A1/ALG11/ALG6/MGAT5/ALG5/FUT8/STT3B/MGAT4A/MAN1A1/DPAGT1/DPM1/MAN1A2/ALG13/MGAT3/ALG1/B4GALT1/DPM2/ALG10/ALG10B/MAN1C1/SRD5A3/RPN1/ALG3/ST6GAL1/MAN2A2/B4GALT2/STT3A/ST6GAL2	28
KEGG	hsa05012	Parkinson disease	124/3289	266/8135	0.02184	0.1658	0.1426	NDUFS1/CASP3/PSMC6/MFN1/NDUFA5/ITPR2/PSMC1/PSMA3/COX7A2/KIF5B/PSMD12/SDHC/SLC39A8/NDUFC1/PSMA2/PRKACB/NDUFA9/PSMD6/SNCA/SLC25A4/PSMB2/PSMA4/EIF2S1/TXN2/COX6B1/SOD1/COX4I2/CALM3/UQCR10/UBE2J1/PSMD1/UBE2G2/GNAS/SLC39A4/VDAC1/PSMB5/TXN/PSMD7/KLC3/PSMC2/COX8A/COX6B2/NDUFB3/TUBB/NDUFS7/UCHL1/UBE2L6/CASP9/CYC1/PSMD14/UQCRB/SLC39A3/ATF6/NDUFA11/SLC18A1/PSMC3/COX5A/MAPK9/NDUFA13/MCU/SLC39A10/TP53/ATP5MC1/NDUFB6/ADCY5/SLC11A2/UQCR11/NDUFV2/UQCRC2/CAMK2G/COX6C/ADRM1/ITPR1/CALM1/PSMC4/COX5B/TUBB4B/PPIF/NDUFS4/LRRK2/NDUFB5/UQCRQ/PSMA8/PSMA7/TUBB8/SLC39A6/SLC18A2/NDUFV3/COX7A2L/PSMD2/NFE2L2/NDUFA2/COX7A1/UQCRC1/PSMD13/SLC39A7/COX4I1/UBE2J2/NDUFC2-KCTD14/DAXX/SLC25A6/PSMA6/ATP5MC2/ATP5PB/PSMD9/MFN2/ATP5MC3/NDUFB2/PSMB7/NDUFAB1/UBA1/HTRA2/CAMK2D/UQCRH/UQCRHL/MAOB/ATP5PF/RPS27A/PSMD8/COX7B/KEAP1/NDUFS8/ATP5F1D/SLC39A5	124
KEGG	hsa03018	RNA degradation	41/3289	79/8135	0.02514	0.1866	0.1606	PNPT1/CNOT1/EXOSC8/DHX36/TENT4B/TTC37/MTREX/DDX6/EXOSC9/DIS3/PNLDC1/CNOT2/CNOT7/HSPA9/DCP1A/XRN1/EXOSC1/XRN2/CNOT6L/CNOT4/EXOSC5/DCP2/PABPC4/DCPS/EXOSC2/CNOT6/EXOSC4/MPHOSPH6/CNOT9/LSM5/C1D/PAN3/LSM4/CNOT8/LSM6/EDC3/PABPC3/TOB2/PABPC1/BTG1/PABPC4L	41
KEGG	hsa04973	Carbohydrate digestion and absorption	26/3289	47/8135	0.02738	0.1954	0.1681	AMY1A/AMY1B/AMY1C/PIK3CA/PIK3CB/PIK3R1/AMY2A/AKT3/PIK3R3/MGAM/PLCB1/G6PC3/AKT2/PIK3CD/SLC2A5/SLC37A4/ATP1A2/PLCB2/PLCB4/ATP1A3/AKT1/LCT/PRKCB/HK1/HK2/ATP1A4	26
KEGG	hsa05214	Glioma	39/3289	75/8135	0.0275	0.1954	0.1681	EGF/CCND1/PIK3CA/RB1/PIK3CB/SOS2/PTEN/PIK3R1/POLK/CAMK1D/AKT3/CALM3/PIK3R3/SHC4/MDM2/PDGFRA/GRB2/PDGFA/NRAS/MAP2K1/SOS1/CDK4/TP53/GADD45B/AKT2/PIK3CD/CAMK2G/CALM1/CDK6/KRAS/PDGFRB/BAK1/AKT1/HRAS/PRKCB/CAMK2D/CDKN2A/E2F3/E2F2	39
KEGG	hsa01524	Platinum drug resistance	38/3289	73/8135	0.02876	0.2001	0.1722	TOP2B/BIRC3/CASP3/MSH6/BIRC2/ATM/PIK3CA/MSH3/REV3L/GSTA1/XPA/FAS/PIK3CB/BCL2/PIK3R1/XIAP/TOP2A/AKT3/PIK3R3/MDM2/CASP9/PDPK1/TP53/GSTA5/AKT2/PIK3CD/SLC31A1/ERCC1/POLH/MLH1/ABCC2/BAK1/AKT1/CDKN2A/GSTA3/GSTP1/BRCA1/BIRC5	38
KEGG	hsa04660	T cell receptor signaling pathway	52/3289	104/8135	0.02946	0.2002	0.1722	NCK1/MAP3K7/PIK3CA/CHUK/DLG1/PDCD1/PPP3R1/PIK3CB/SOS2/PRKCQ/PIK3R1/TEC/NFATC3/CDC42/AKT3/PIK3R3/PPP3CC/IKBKB/NFKBIE/GRB2/RASGRP1/CD40LG/ITK/NRAS/MAP2K1/PDPK1/MALT1/PAK1/PTPRC/FYN/SOS1/LCP2/MAPK9/CDK4/TNF/AKT2/PIK3CD/GSK3B/KRAS/CD8A/CTLA4/ICOS/PAK6/VAV2/CBLB/NFATC2/AKT1/CD3E/PTPN6/HRAS/BUB1B-PAK6/PAK4	52
KEGG	hsa00240	Pyrimidine metabolism	31/3289	58/8135	0.03014	0.2002	0.1722	NT5C3A/NME7/RRM2B/AK9/DCK/NME1/ENTPD6/CMPK2/UPP2/DCTD/NUDT2/NME6/NT5C1B/DHODH/TYMS/CANT1/CMPK1/DCTPP1/CTPS1/ENTPD8/DTYMK/CAD/NT5C1A/NT5C2/UPP1/UCK1/DUT/CDA/ENTPD4/NT5C3B/RRM1	31
KEGG	hsa04150	mTOR signaling pathway	75/3289	156/8135	0.03057	0.2002	0.1722	MIOS/RPS6KA3/LPIN2/PRKAA1/ATP6V1C1/CAB39/PIK3CA/RPS6/RRAGB/CHUK/ATP6V1H/CAB39L/PIK3CB/SOS2/PTEN/EIF4EBP1/FZD6/RRAGC/PIK3R1/DVL3/ATP6V1A/AKT3/PIK3R3/IKBKB/GRB2/WNT10A/FZD3/FZD7/CASTOR1/SEH1L/RICTOR/EIF4E1B/NRAS/MAP2K1/ATP6V1G2/PDPK1/SOS1/SKP2/EIF4E2/ATP6V1G1/ATP6V1F/ULK1/FNIP1/TNF/AKT2/PIK3CD/GSK3B/DEPDC5/SLC7A5/SLC3A2/ATP6V1D/STRADB/KRAS/WNT7B/DDIT4/LAMTOR2/WNT5B/ATP6V1C2/LAMTOR5/FNIP2/LRP6/ULK2/AKT1/WNT10B/RRAGD/DVL1/HRAS/ATP6V1B2/WNT3/PRKCB/SESN2/EIF4B/PRR5/DVL2/CASTOR2	75
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	8/3289	11/8135	0.03126	0.2008	0.1727	VKORC1L1/COQ6/TAT/COQ7/COQ2/VKORC1/COQ5/NQO1	8
KEGG	hsa01250	Biosynthesis of nucleotide sugars	21/3289	37/8135	0.03253	0.205	0.1764	GFPT1/GMDS/PGM3/UGP2/PGM2/FPGT/GALE/UAP1/TGDS/PGM1/NANP/NANS/GALK1/MIOX/GMPPB/CMAS/PMM2/UXS1/NAGK/HK1/HK2	21
KEGG	hsa01232	Nucleotide metabolism	43/3289	85/8135	0.03626	0.2229	0.1917	NT5C3A/NME7/AK6/AK3/RRM2B/AK9/ADK/ADA/DCK/XDH/AK1/NME1/ENTPD6/NTPCR/ADA2/AMPD2/CMPK2/UPP2/DCTD/NME6/NT5C1B/HPRT1/TYMS/GMPR/CANT1/CMPK1/DCTPP1/CTPS1/AK8/ENTPD8/DTYMK/GMPS/NT5C1A/NT5C2/UPP1/GMPR2/UCK1/AK4/DUT/CDA/ENTPD4/NT5C3B/RRM1	43
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	16/3289	27/8135	0.0371	0.2229	0.1917	FUT2/B3GNT3/A4GALT/FUT4/ABO/B4GALT1/FUT1/ST3GAL6/B3GALNT1/B3GNT2/FUT9/ST3GAL4/FUT6/B3GNT5/FUT5/B4GALT2	16
KEGG	hsa03430	Mismatch repair	14/3289	23/8135	0.03817	0.2229	0.1917	RPA4/MSH6/PMS2/MSH3/RFC1/EXO1/RFC2/RFC3/RFC5/RPA1/MLH1/POLD2/RPA2/MLH3	14
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	12/3289	19/8135	0.03821	0.2229	0.1917	ABHD14A-ACY1/BCAT2/GOT1/ACO2/IDH1/ACY1/GPT/GOT2/ACO1/AADAT/IDH3A/IDH3B	12
KEGG	hsa05135	Yersinia infection	66/3289	137/8135	0.0387	0.2229	0.1917	ITGA4/RPS6KA3/PKN2/ITGB1/MAP3K7/CASP1/FN1/PIK3CA/CHUK/ARHGEF12/FYB1/ACTR3/ACTR2/ROCK1/TBK1/PIK3CB/TLR4/TAB2/PIK3R1/NFATC3/IRAK4/RAC2/CDC42/ROCK2/AKT3/MAP2K6/WAS/PIK3R3/GIT2/IKBKB/ARPC3/ARPC4/GNAQ/ARPC1A/RHOG/ACTR3C/MAP2K1/WIPF2/LCP2/BAIAP2/ELMO2/CRKL/MAPK9/ACTR3B/TNF/AKT2/PIK3CD/GSK3B/PYCARD/MYD88/ARPC2/RAC3/IFNB1/CCL2/PIP5K1C/CD8A/CXCL8/TAB1/ACTG1/VAV2/PXN/ARPC5/NFATC2/AKT1/ARPC5L/BCAR1	66
KEGG	hsa05010	Alzheimer disease	172/3289	384/8135	0.04222	0.239	0.2056	PIK3R4/NDUFS1/CASP3/PSMC6/NDUFA5/BACE1/ITPR2/ATG2B/EIF2AK2/PSMC1/PSMA3/COX7A2/PIK3CA/AXIN2/KIF5B/CHUK/PSMD12/SDHC/IDE/FAS/PPP3R1/PIK3CB/PIK3C3/ADAM10/SLC39A8/NDUFC1/FZD6/NCSTN/APC/PIK3R1/PSMA2/AGER/DVL3/NDUFA9/PSMD6/SNCA/SLC25A4/PSMB2/PSMA4/CSNK1A1L/EIF2S1/CSNK2A2/COX6B1/AKT3/COX4I2/CALM3/CSNK2B/PIK3R3/UQCR10/AXIN1/PSMD1/PPP3CC/IKBKB/SLC39A4/VDAC1/PSMB5/PSMD7/KLC3/PLCB1/PSMC2/COX8A/COX6B2/GNAQ/NDUFB3/TUBB/NDUFS7/WNT10A/ATG101/FZD3/HSD17B10/FZD7/CASP9/CYC1/PSMD14/UQCRB/NRAS/MAP2K1/SLC39A3/ATF6/NDUFA11/PSMC3/COX5A/PSEN2/RTN4/MAPK9/ADAM17/NDUFA13/MCU/CDK5R1/SLC39A10/ULK1/ATP5MC1/NDUFB6/TNF/SLC11A2/AKT2/PIK3CD/NOX1/GSK3B/UQCR11/NDUFV2/UQCRC2/COX6C/ADRM1/ITPR1/PSENEN/CALM1/PSMC4/COX5B/TUBB4B/PPIF/CSNK1A1/NDUFS4/NDUFB5/UQCRQ/LRP1/PSMA8/PSMA7/TUBB8/KRAS/WNT7B/SLC39A6/NDUFV3/COX7A2L/PSMD2/CSNK2A1/CACNA1F/NRBF2/NDUFA2/PSEN1/COX7A1/WIPI2/WNT5B/RB1CC1/UQCRC1/PSMD13/SLC39A7/COX4I1/APH1B/NDUFC2-KCTD14/PLCB2/PLCB4/SLC25A6/PSMA6/ATP5MC2/ATP5PB/PSMD9/ATP5MC3/APC2/NDUFB2/PSMB7/LRP6/ULK2/AKT1/NDUFAB1/WNT10B/DVL1/HRAS/WNT3/ATG13/NAE1/UQCRH/UQCRHL/ATP5PF/LPL/GRIN2B/PSMD8/COX7B/NDUFS8/DVL2/ATP5F1D/SLC39A5	172
KEGG	hsa00562	Inositol phosphate metabolism	37/3289	73/8135	0.04808	0.2676	0.2303	SACM1L/MTMR2/FIG4/PIK3CA/IPMK/MTMR6/MINPP1/PIK3CB/PIK3C3/PTEN/PIKFYVE/PI4K2B/INPP5F/PIK3C2A/TPI1/ALDH6A1/PLCB1/SYNJ2/INPP1/PIP4K2C/INPP5E/SYNJ1/PIK3CD/PI4K2A/MIOX/MTMR8/PLCD3/PIP5K1C/INPP4B/PLCZ1/PLCB2/PLCB4/PIP4K2A/INPP5J/ITPKC/INPP5K/ITPKB	37
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	26/3289	49/8135	0.04945	0.2708	0.233	GFPT1/GMDS/PGM3/UGP2/PGM2/FPGT/CYB5R4/GALE/UAP1/GNPDA2/PGM1/NANP/HEXB/RENBP/NANS/GNPDA1/GALK1/GMPPB/AMDHD2/CMAS/PMM2/UXS1/NAGK/NPL/HK1/HK2	26
KEGG	hsa04510	Focal adhesion	93/3289	201/8135	0.05166	0.2783	0.2395	ITGA4/EGF/MYLPF/BIRC3/ITGB1/CCND1/BIRC2/FN1/PIK3CA/PPP1CB/ROCK1/MYL5/PIK3CB/COL9A2/PPP1CC/SOS2/PTEN/BCL2/PIK3R1/RAC2/XIAP/MYL12A/CDC42/COL6A3/ROCK2/ITGA1/AKT3/FLNC/PIK3R3/SHC4/COL6A1/RAP1A/PGF/PDGFRA/GRB2/VTN/ACTN4/PDGFA/ITGA2/THBS1/MAP2K1/THBS4/PDPK1/LAMC1/ILK/PAK1/FYN/SOS1/CRKL/PARVG/MAPK9/TNR/ITGA9/AKT2/PIK3CD/GSK3B/CCND2/FLNB/PPP1R12C/RAC3/PIP5K1C/TLN1/TNN/PPP1R12A/LAMA3/VEGFB/KDR/PDGFRB/ACTG1/PAK6/VAV2/PXN/TLN2/AKT1/CHAD/ITGAV/HRAS/VEGFA/COL6A5/BUB1B-PAK6/PRKCB/COL4A2/COL1A2/ITGB4/COL9A3/MYL12B/MET/CAV1/ARHGAP35/MYL9/PAK4/BCAR1/PARVB	93
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/3289	26/8135	0.0565	0.2995	0.2577	PIGB/PIGN/PIGF/PIGA/PIGM/PIGK/PIGS/PIGG/PIGO/PIGV/DPM2/PIGW/PIGZ/PGAP1/GPLD1	15
KEGG	hsa04071	Sphingolipid signaling pathway	57/3289	119/8135	0.05803	0.3029	0.2606	PPP2R5E/ASAH1/SGPP1/PIK3CA/PPP2R5A/GNA13/CERS6/ROCK1/PIK3CB/PTEN/BCL2/PLD1/PIK3R1/PPP2R3C/PPP2R1B/RAC2/NSMAF/CERS5/ROCK2/AKT3/GNA12/PIK3R3/CERS3/PLCB1/GNAQ/SGPL1/NRAS/MAP2K1/PDPK1/FCER1G/PPP2R3A/FYN/ACER2/MAPK9/PRKCZ/TP53/PPP2CA/TNF/ADORA3/AKT2/PIK3CD/S1PR1/KNG1/CTSD/KRAS/PPP2R2A/RAC3/PRKCE/DEGS2/PLCB2/PLCB4/SPHK1/AKT1/HRAS/SPHK2/GAB2/PRKCB	57
KEGG	hsa04611	Platelet activation	59/3289	124/8135	0.06221	0.3161	0.272	PRKCI/ITGB1/ITPR2/GUCY1B1/PIK3CA/ARHGEF12/P2RY12/GNA13/PLA2G4A/PPP1CB/ROCK1/PIK3CB/PPP1CC/PIK3R1/PRKACB/P2RY1/MYL12A/ROCK2/AKT3/PIK3R3/GNAS/RAP1A/RASGRP1/PLCB1/GNAQ/ITGA2/F2R/FCER1G/FYN/LCP2/PIK3R5/PRKCZ/LYN/GP6/ADCY5/AKT2/PIK3CD/ITPR1/GUCY1A1/TLN1/PPP1R12A/ACTG1/PLCB2/PTGIR/PLCB4/ADCY2/TLN2/VAMP8/GP5/PRKG2/AKT1/PTGS1/COL1A2/ADCY3/APBB1IP/MYL12B/TBXA2R/ARHGAP35/TBXAS1	59
KEGG	hsa04068	FoxO signaling pathway	62/3289	131/8135	0.06349	0.3161	0.272	EGF/PRKAA1/HOMER1/FBXO25/CCND1/SMAD4/PLK4/ATM/PIK3CA/TNFSF10/RBL2/CHUK/PIK3CB/SOS2/PTEN/FOXO3/IL7R/PIK3R1/KLF2/TGFB2/SIRT1/GABARAP/STK4/AGAP2/AKT3/PIK3R3/IKBKB/MDM2/PRKAB1/GRB2/NRAS/MAP2K1/PDPK1/CCNB2/EP300/USP7/SOS1/SKP2/HOMER2/PRKAG1/MAPK9/GADD45B/FOXO1/ATG12/G6PC3/AKT2/PIK3CD/S1PR1/CCND2/SMAD3/PRKAG3/SGK3/KRAS/FBXO32/TGFB1/PLK1/AKT1/BCL2L11/PCK2/HRAS/CDKN1B/PRMT1	62
KEGG	hsa05110	Vibrio cholerae infection	26/3289	50/8135	0.06436	0.3161	0.272	ATP6V1C1/ATP6V1H/ERO1A/PRKACB/ATP6V1A/SEC61A1/SEC61A2/SLC12A2/GNAS/ATP6V1G2/ATP6V0D1/ATP6V0A1/KDELR1/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V1D/ATP6V0A2/ACTG1/CFTR/ATP6V1C2/ATP6V1B2/KDELR3/ADCY3/KCNQ1/ATP6AP1	26
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	47/3289	97/8135	0.06562	0.3161	0.272	ASAP1/PIK3CA/PLA2G4A/ACTR3/ACTR2/PIK3CB/FCGR3B/PLD1/PIK3R1/RAC2/CDC42/AKT3/WAS/PIK3R3/WASF1/ARPC3/ARPC4/ARPC1A/ACTR3C/MAP2K1/WASF3/PAK1/PTPRC/PLPP1/CRKL/LYN/ACTR3B/AKT2/PIK3CD/ASAP3/FCGR3A/ARPC2/PIP5K1C/PRKCE/VAV2/PLPP3/MYO10/SPHK1/ARPC5/AKT1/CFL2/SPHK2/GAB2/PRKCB/DNM2/CFL1/ARPC5L	47
KEGG	hsa05415	Diabetic cardiomyopathy	93/3289	203/8135	0.06611	0.3161	0.272	GFPT1/NDUFS1/GYS2/NDUFA5/COX7A2/PIK3CA/SDHC/TBC1D4/PPP1CB/PIK3CB/PPP1CC/PTEN/NDUFC1/PIK3R1/TGFB2/AGER/NDUFA9/RAC2/SLC25A4/COX6B1/SMAD2/AKT3/COX4I2/PIK3R3/UQCR10/VDAC1/PLCB1/COX8A/COX6B2/NDUFB3/NDUFS7/CYC1/UQCRB/NDUFA11/COX5A/MAPK9/PRKCZ/NDUFA13/ATP5MC1/NDUFB6/AKT2/PIK3CD/GSK3B/UQCR11/NDUFV2/UQCRC2/SMAD3/CAMK2G/COX6C/PDK2/COX5B/PPIF/NDUFS4/CTSD/NDUFB5/UQCRQ/PDK4/PTPA/PDHB/NDUFV3/COX7A2L/PARP1/NDUFA2/COX7A1/PLN/UQCRC1/CYBA/COX4I1/CMA1/TGFB1/NDUFC2-KCTD14/PLCB2/PLCB4/SLC25A6/ATP5MC2/ATP5PB/ATP5MC3/NDUFB2/AKT1/NDUFAB1/PDK3/MPC2/PRKCB/CAMK2D/UQCRH/UQCRHL/COL1A2/ATP5PF/COX7B/PDHA1/NDUFS8/ATP5F1D/NCF2	93
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	39/3289	79/8135	0.06626	0.3161	0.272	EGF/PIK3CA/RPS6/JAK2/PIK3CB/SOS2/PTEN/EIF4EBP1/FOXO3/NF1/BCL2/PIK3R1/AKT3/PIK3R3/SHC4/PDGFRA/GRB2/PDGFA/EIF4E1B/NRAS/MAP2K1/SOS1/EIF4E2/AKT2/PIK3CD/GSK3B/KRAS/FGF2/IL6R/KDR/PDGFRB/GAS6/GAB1/AKT1/BCL2L11/HRAS/VEGFA/PRKCB/MET	39
KEGG	hsa04370	VEGF signaling pathway	30/3289	59/8135	0.06737	0.3169	0.2727	PIK3CA/PLA2G4A/PPP3R1/PIK3CB/MAPKAPK2/PIK3R1/RAC2/CDC42/AKT3/PIK3R3/MAPKAPK3/PPP3CC/CASP9/NRAS/MAP2K1/SH2D2A/HSPB1/AKT2/PIK3CD/KRAS/RAC3/KDR/PXN/SPHK1/NFATC2/AKT1/HRAS/SPHK2/VEGFA/PRKCB	30
KEGG	hsa04932	Non-alcoholic fatty liver disease	72/3289	155/8135	0.07284	0.3312	0.285	NDUFS1/PRKAA1/CASP3/NDUFA5/COX7A2/PIK3CA/SDHC/ITCH/FAS/PIK3CB/NR1H3/NDUFC1/PIK3R1/NDUFA9/CDC42/EIF2S1/COX6B1/AKT3/COX4I2/MLX/PIK3R3/UQCR10/IKBKB/CYP2E1/PRKAB1/COX8A/RXRA/COX6B2/NDUFB3/NDUFS7/CYC1/UQCRB/SREBF1/NDUFA11/PRKAG1/COX5A/MAPK9/NDUFA13/NDUFB6/TNF/SOCS3/AKT2/PIK3CD/GSK3B/UQCR11/NDUFV2/UQCRC2/COX6C/COX5B/PRKAG3/NDUFS4/NDUFB5/UQCRQ/ADIPOR1/NDUFV3/COX7A2L/NDUFA2/IL6R/COX7A1/CXCL8/UQCRC1/COX4I1/TGFB1/NDUFC2-KCTD14/NDUFB2/AKT1/NDUFAB1/BCL2L11/UQCRH/UQCRHL/COX7B/NDUFS8	72
KEGG	hsa04918	Thyroid hormone synthesis	37/3289	75/8135	0.073	0.3312	0.285	ITPR2/HSP90B1/TTR/TTF1/CREB1/PRKACB/GNAS/TSHR/PLCB1/DUOXA2/CREB3L4/GNAQ/GPX3/CREB5/GPX1/ADCY5/TG/ITPR1/CREB3/GPX7/GPX6/GPX2/ASGR2/ATP1A2/PLCB2/ASGR1/PLCB4/ADCY2/ATP1A3/PAX8/SLC26A4/CREB3L1/PRKCB/ADCY3/CANX/DUOX1/ATP1A4	37
KEGG	hsa04714	Thermogenesis	105/3289	232/8135	0.07372	0.3312	0.285	NDUFS1/RPS6KA3/PRKAA1/KDM3A/NDUFA5/NDUFAF7/COX7A2/SMARCE1/RPS6/ACSL3/SDHC/SOS2/NDUFC1/ACSL4/CREB1/PRKACB/NDUFA9/COX17/COX14/NDUFAF5/ACSL5/COA7/COX11/COX6B1/COA3/COX4I2/UQCR10/BMP8B/GNAS/PRKAB1/GRB2/COA4/COX8A/COX6B2/CREB3L4/NDUFB3/NDUFS7/CPT1C/CYC1/UQCRB/ACSL1/NRAS/DPF1/SMARCC2/BMP8A/NDUFA11/SMARCC1/SOS1/CPT1A/CREB5/PRKAG1/COX5A/ATP5MF/NDUFA13/ATP5MC1/NDUFB6/ADCY5/SLC25A20/UQCR11/NDUFV2/UQCRC2/NPR1/COX6C/FGFR1/COX5B/PRKAG3/NDUFS4/CREB3/NDUFB5/UQCRQ/KRAS/NDUFV3/SLC25A29/COX7A2L/NDUFA2/MGLL/COX7A1/UQCRC1/COX4I1/SMARCD1/ACTG1/NDUFC2-KCTD14/ADCY2/ATP5MC2/ATP5PB/ATP5MC3/NDUFB2/PRKG2/NDUFAB1/ACTL6B/PLIN1/NPPA/HRAS/COX15/CREB3L1/UQCRH/UQCRHL/LIPE/ATP5PF/ADCY3/FRS2/COX7B/NDUFS8/KLB/ATP5F1D	105
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	48/3289	100/8135	0.07438	0.3312	0.285	CASP3/CCND1/SMAD4/FN1/PIK3CA/JAK2/PIK3CB/BCL2/PIK3R1/TGFB2/AGER/CDC42/SMAD2/AKT3/PIK3R3/PLCB1/STAT5B/PIM1/NRAS/MAPK9/PRKCZ/CDK4/FOXO1/TNF/AKT2/PIK3CD/NOX1/STAT1/SMAD3/KRAS/PLCD3/CCL2/PRKCE/CXCL8/VEGFB/TGFB1/PLCB2/PLCB4/VCAM1/AKT1/HRAS/STAT5A/VEGFA/PRKCB/COL4A2/CDKN1B/COL1A2/ICAM1	48
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	101/3289	223/8135	0.07679	0.3375	0.2904	NDUFS1/EGF/NDUFA5/COX7A2/CYP1B1/PIK3CA/PRKD3/CHUK/SDHC/GSTA1/PIK3CB/SOS2/PTEN/NDUFC1/HIF1A/FOXO3/PLD1/PIK3R1/NDUFA9/SLC25A4/ABL2/COX6B1/EPHX4/SOD1/AKT3/COX4I2/PIK3R3/UQCR10/IKBKB/AKR1C3/CYP2E1/VDAC1/GRB2/COX8A/COX6B2/NDUFB3/NDUFS7/CYC1/UQCRB/NRAS/MAP2K1/PDPK1/NDUFA11/SOS1/SLC26A2/CBR1/AKR1C1/COX5A/MAPK9/NDUFA13/ATP5MC1/GSTA5/NDUFB6/AKT2/PIK3CD/NOX1/UQCR11/NDUFV2/UQCRC2/COX6C/COX5B/PPIF/NDUFS4/NDUFB5/UQCRQ/KRAS/NDUFV3/HMOX1/COX7A2L/NFE2L2/NDUFA2/COX7A1/UQCRC1/CYBA/COX4I1/NDUFC2-KCTD14/AKR1A1/SLC26A1/SLC25A6/ATP5MC2/ATP5PB/CYP1A1/ATP5MC3/NDUFB2/AKT1/PTPN11/NDUFAB1/HRAS/VEGFA/UQCRH/UQCRHL/ATP5PF/NQO1/ARNT/GSTA3/COX7B/KEAP1/MET/NDUFS8/ATP5F1D/NCF2	101
KEGG	hsa05131	Shigellosis	111/3289	247/8135	0.08116	0.3521	0.3029	PIK3R4/MYLPF/SEPTIN11/GLMN/ITGB1/MAP3K7/ITPR2/CASP1/CBX3/UBE2V2/FNBP1/ATM/PIK3CA/RPS6KA5/RRAGB/CHUK/ACTR3/ACTR2/ROCK1/TBK1/MYL5/PIK3CB/PIK3C3/CD44/PRKCQ/TLR4/FOXO3/TRAF5/CUL1/SEPTIN6/RRAGC/BCL2/TAB2/PIK3R1/CALCOCO2/C3/MYL12A/CDC42/ROCK2/SKP1/AKT3/PIK3R3/IKBKB/MDM2/VDAC1/FNBP1L/WASF1/UBE2D4/ACTN4/ARPC3/PLCB1/ARPC4/TLR5/ARPC1A/MAP1LC3B/ACTR3C/CAPNS1/MALT1/NAIP/ILK/CASP4/SEPTIN3/ELMO2/CRKL/MAPK9/ARHGEF2/TP53/FOXO1/ATG12/ACTR3B/TNF/AKT2/PIK3CD/GSK3B/PYCARD/RIPK2/ITPR1/MYD88/ARPC2/UBE2D1/SEPTIN2/SEPTIN9/PLCD3/IFNB1/TLN1/PRKCE/WIPI2/CXCL8/CYTH1/TAB1/TECPR1/ACTG1/PLCZ1/PLCB2/PXN/PLCB4/TLN2/ARPC5/AKT1/CYTH2/RRAGD/RIPK1/TAB3/RPS27A/CTTN/HK1/MYL12B/ARPC5L/HK2/MYL9/BCAR1	111
KEGG	hsa05222	Small cell lung cancer	44/3289	92/8135	0.0897	0.3841	0.3305	BIRC3/CASP3/ITGB1/CCND1/BIRC2/FN1/PIK3CA/CCNE2/CHUK/RB1/PIK3CB/PTEN/TRAF5/BCL2/PIK3R1/POLK/XIAP/AKT3/PIK3R3/IKBKB/MAX/RXRA/CKS1B/ITGA2/CASP9/LAMC1/SKP2/CDK4/TP53/GADD45B/AKT2/PIK3CD/CDK6/LAMA3/BIRC7/BAK1/AKT1/ITGAV/COL4A2/CCNE1/CDKN1B/E2F3/CKS2/E2F2	44
KEGG	hsa00514	Other types of O-glycan biosynthesis	24/3289	47/8135	0.09088	0.3842	0.3306	GALNT3/GALNT7/C1GALT1/RFNG/POMT2/EOGT/COLGALT2/GALNT4/POGLUT1/POC1B-GALNT4/GALNT10/GALNT1/B4GALT1/OGT/C1GALT1C1/POFUT1/GALNT11/GALNT14/ST6GAL1/XXYLT1/MFNG/B4GALT2/GALNT8/ST6GAL2	24
KEGG	hsa04152	AMPK signaling pathway	56/3289	120/8135	0.09589	0.4003	0.3444	PPP2R5E/PRKAA1/GYS2/MAP3K7/CCND1/CAB39/PIK3CA/HMGCR/PPP2R5A/CAB39L/RAB14/PIK3CB/EIF4EBP1/PFKFB2/FOXO3/CREB1/PIK3R1/FBP1/SIRT1/PPP2R3C/PPP2R1B/AKT3/PIK3R3/PRKAB1/CREB3L4/TBC1D1/RAB2A/CPT1C/PDPK1/SREBF1/PPP2R3A/CPT1A/CREB5/PRKAG1/ULK1/FOXO1/PPP2CA/G6PC3/AKT2/PIK3CD/RAB8A/PRKAG3/CREB3/STRADB/PPP2R2A/ADIPOR1/SCD/RAB11B/RAB10/CFTR/AKT1/ELAVL1/PCK2/CREB3L1/LIPE/CCNA1	56
KEGG	hsa05218	Melanoma	35/3289	72/8135	0.09746	0.4003	0.3445	EGF/FGF19/CCND1/PIK3CA/RB1/PIK3CB/PTEN/MITF/PIK3R1/POLK/AKT3/PIK3R3/MDM2/PDGFRA/PDGFA/NRAS/MAP2K1/CDK4/TP53/GADD45B/AKT2/PIK3CD/FGFR1/FGF10/CDK6/KRAS/FGF2/PDGFRB/BAK1/AKT1/HRAS/CDKN2A/E2F3/E2F2/MET	35
KEGG	hsa05161	Hepatitis B	74/3289	162/8135	0.09829	0.4003	0.3445	IFIH1/DDX58/CASP3/MAP3K7/SMAD4/PIK3CA/CCNE2/CHUK/JAK2/RB1/TLR2/TBK1/FAS/PIK3CB/SOS2/TLR4/BCL2/CREB1/TAB2/YWHAZ/PIK3R1/TGFB2/NFATC3/IRAK4/AKT3/MAP2K6/YWHAB/PIK3R3/IKBKB/IFNAR1/GRB2/CREB3L4/NFATC4/STAT5B/CASP9/MAP3K1/NRAS/MAP2K1/DDX3X/EP300/SOS1/TLR3/CREB5/MAPK9/TP53/TNF/AKT2/PIK3CD/STAT1/SMAD3/MYD88/CREB3/JAK3/KRAS/IFNB1/TYK2/CXCL8/TAB1/STAT4/TGFB1/DDB1/NFATC2/AKT1/HRAS/STAT5A/CREB3L1/PRKCB/IFNA21/CCNE1/CCNA1/E2F3/ATP6AP1/E2F2/BIRC5	74
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	9/3289	15/8135	0.1009	0.406	0.3493	FUT2/A4GALT/HEXB/NAGA/FUT1/B3GALNT1/FUT9/GBGT1/A3GALT2	9
KEGG	hsa04914	Progesterone-mediated oocyte maturation	48/3289	102/8135	0.1024	0.4071	0.3503	ANAPC4/RPS6KA3/PIK3CA/BUB1/CDK1/CDC16/ANAPC13/PIK3CB/MAD2L1/PDE3B/PIK3R1/PRKACB/CDC27/ANAPC16/MAD2L2/AKT3/SPDYE3/ANAPC11/PIK3R3/SPDYE5/SPDYE2B/CDC26/CPEB4/CPEB3/SPDYE18/SPDYE11/MAP2K1/CCNB2/FZR1/ANAPC15/MAPK9/ANAPC10/SPDYE1/ADCY5/AKT2/PIK3CD/PKMYT1/KRAS/SPDYE17/PLK1/ADCY2/AKT1/SPDYE16/SPDYE2/SPDYE6/CCNA1/ADCY3/KIF22	48
KEGG	hsa00020	Citrate cycle (TCA cycle)	16/3289	30/8135	0.1053	0.4072	0.3504	SDHC/DLD/SUCLA2/SUCLG2/ACO2/ACLY/IDH1/PDHB/ACO1/MDH1/DLAT/PCK2/IDH3A/IDH3B/PDHA1/MDH2	16
KEGG	hsa05323	Rheumatoid arthritis	44/3289	93/8135	0.1055	0.4072	0.3504	ATP6V1C1/HLA-DMB/TNFSF13B/ATP6V1H/TLR2/HLA-DRA/HLA-DMA/TLR4/TGFB2/CXCL5/ATP6V1A/HLA-DOA/HLA-DQA1/CD86/ITGAL/ANGPT1/HLA-DQA2/CCL3L1/ATP6V1G2/ATP6V0D1/ATP6V0A1/ATP6V1G1/ATP6V1F/ATP6V0B/TNF/CTSK/CCL3/HLA-DPA1/ATP6V1D/ATP6V0A2/CCL2/HLA-DQB1/CXCL3/CTLA4/CXCL8/ACP5/TGFB1/ATP6V1C2/ATP6V1B2/VEGFA/ICAM1/ATP6AP1/CTSL/IL15	44
KEGG	hsa04216	Ferroptosis	21/3289	41/8135	0.1061	0.4072	0.3504	CP/ACSL3/NCOA4/SLC39A8/ACSL4/SLC40A1/ACSL5/TFRC/MAP1LC3B/ALOX15/ACSL1/PCBP1/TP53/ATG7/SLC11A2/SLC3A2/HMOX1/SAT1/STEAP3/LPCAT3/GSS	21
KEGG	hsa05205	Proteoglycans in cancer	92/3289	205/8135	0.1075	0.4078	0.3509	IQGAP1/CASP3/ITGB1/CCND1/ITPR2/FN1/PIK3CA/RPS6/ARHGEF12/TLR2/DDX5/PPP1CB/ROCK1/FAS/PIK3CB/PPP1CC/SOS2/CD44/FZD6/TLR4/HIF1A/PIK3R1/PRKACB/TGFB2/PDCD4/CDC42/ROCK2/SMAD2/AKT3/FLNC/MRAS/PIK3R3/MDM2/GRB2/VTN/EZR/WNT10A/ITGA2/FZD3/FZD7/THBS1/PLAUR/NRAS/MAP2K1/PDPK1/RRAS/HSPB2/PAK1/SOS1/DROSHA/TP53/TNF/AKT2/PIK3CD/TIAM1/FLNB/CAMK2G/FGFR1/ITPR1/PPP1R12C/ANK1/KRAS/HPSE2/WNT7B/FGF2/PPP1R12A/WNT5B/KDR/TGFB1/ACTG1/VAV2/PXN/GAB1/SLC9A1/AKT1/PTPN11/PTPN6/WNT10B/ITGAV/HRAS/VEGFA/WNT3/PRKCB/CAMK2D/COL1A2/EIF4B/CTTN/FRS2/CTSL/MET/CAV1/MSN	92
KEGG	hsa04330	Notch signaling pathway	29/3289	59/8135	0.1087	0.4078	0.3509	DTX3L/HDAC2/CIR1/SNW1/MAML2/NCSTN/KAT2B/DVL3/RFNG/DTX4/ATXN1/JAG2/EP300/PSEN2/ADAM17/NCOR2/PSENEN/DLL4/CTBP1/DLL3/NOTCH4/PSEN1/HES1/NUMB/APH1B/TLE2/DVL1/MFNG/DVL2	29
KEGG	hsa05225	Hepatocellular carcinoma	76/3289	168/8135	0.1147	0.4224	0.3634	CCND1/ARID2/SMAD4/SMARCE1/PIK3CA/AXIN2/PBRM1/RB1/GSTA1/PIK3CB/SOS2/PTEN/FZD6/APC/PIK3R1/TGFB2/DVL3/POLK/CSNK1A1L/SMAD2/AKT3/PIK3R3/AXIN1/SHC4/GRB2/WNT10A/FZD3/FZD7/NRAS/MAP2K1/DPF1/SMARCC2/SMARCC1/SOS1/TERC/PHF10/TCF7/CDK4/TP53/GSTA5/GADD45B/AKT2/PIK3CD/GSK3B/SMAD3/CSNK1A1/CDK6/KRAS/WNT7B/BRD7/HMOX1/NFE2L2/WNT5B/SMARCD1/TGFB1/ACTG1/GAB1/BAK1/APC2/LRP6/AKT1/ACTL6B/WNT10B/DVL1/HRAS/WNT3/PRKCB/NQO1/CDKN2A/GSTA3/E2F3/GSTP1/E2F2/KEAP1/MET/DVL2	76
KEGG	hsa04935	Growth hormone synthesis, secretion and action	55/3289	119/8135	0.1151	0.4224	0.3634	ITPR2/PIK3CA/JAK2/PIK3CB/SOS2/CREB1/PIK3R1/PRKACB/AKT3/MAP2K6/SSTR1/PIK3R3/SHC4/GNAS/GHSR/GRB2/PLCB1/CREB3L4/GNAQ/STAT5B/MAP3K1/NRAS/MAP2K1/CSH1/EP300/SOS1/CREB5/CRKL/MAPK9/ADCY5/SOCS3/AKT2/PIK3CD/GSK3B/STAT1/ITPR1/CREB3/KRAS/CACNA1F/GHRHR/GNA11/IGFALS/PLCB2/PLCB4/ADCY2/JUNB/CSH2/AKT1/HRAS/IGFBP3/STAT5A/CREB3L1/PRKCB/ADCY3/BCAR1	55
KEGG	hsa04114	Oocyte meiosis	60/3289	131/8135	0.1207	0.4357	0.3748	PPP2R5E/ANAPC4/RPS6KA3/ITPR2/SMC3/CCNE2/PPP2R5A/BUB1/CDK1/CDC16/FBXO5/PPP1CB/ANAPC13/PPP3R1/PPP1CC/MAD2L1/SLK/CUL1/YWHAZ/PRKACB/PPP2R1B/CDC27/ANAPC16/MAD2L2/SKP1/CALM3/SPDYE3/ANAPC11/YWHAB/PPP3CC/SPDYE5/SPDYE2B/CDC26/CPEB4/CPEB3/SPDYE18/SPDYE11/MAP2K1/CCNB2/PTTG2/ANAPC15/ANAPC10/SPDYE1/ADCY5/PPP2CA/PKMYT1/CAMK2G/ITPR1/CALM1/SPDYE17/PLCZ1/PLK1/ADCY2/SPDYE16/SPDYE2/SPDYE6/CAMK2D/CCNE1/ADCY3/SMC1A	60
KEGG	hsa04810	Regulation of actin cytoskeleton	97/3289	218/8135	0.1213	0.4357	0.3748	ITGA4/EGF/FGF19/IQGAP1/MYLPF/ITGB1/FN1/PIK3CA/ARHGEF12/GNA13/ACTR3/PPP1CB/ACTR2/ROCK1/NCKAP1/MYL5/PIK3CB/PPP1CC/SOS2/APC/PIK3R1/PIKFYVE/RAC2/ARHGEF6/MYL12A/CDC42/ROCK2/ITGA1/MRAS/GNA12/DIAPH2/PIK3R3/PDGFRA/WASF1/ITGAL/ACTN4/PDGFA/ARPC3/ARPC4/EZR/ARHGEF4/ITGA2/ARPC1A/F2R/ACTR3C/IQGAP3/NRAS/MAP2K1/RRAS/PAK1/PIP4K2C/SOS1/BAIAP2/CRKL/ITGA9/ACTR3B/PIK3CD/KNG1/TIAM1/FGFR1/PPP1R12C/FGF10/ARPC2/KRAS/FGF2/RAC3/PIP5K1C/INSRR/FGD3/FGD1/PPP1R12A/PDGFRB/ACTG1/PAK6/ABI2/IQGAP2/VAV2/PXN/ARPC5/SLC9A1/APC2/SSH1/NCKAP1L/PIP4K2A/ITGAV/CFL2/HRAS/BUB1B-PAK6/ITGB4/CFL1/MYL12B/ARPC5L/ARHGAP35/MYL9/PAK4/MSN/BCAR1	97
KEGG	hsa04350	TGF-beta signaling pathway	44/3289	94/8135	0.123	0.4372	0.3762	RBL1/SMURF2/INHBA/FBN1/SMAD4/ROCK1/BMPR2/CUL1/TGFB2/ACVR1B/GDF7/PPP2R1B/SMAD2/SKP1/TGIF1/BMP8B/ZFYVE16/SMAD5/BMP6/CHRD/THBS1/FST/EP300/BMP8A/LEFTY1/LTBP1/ACVR2B/TGIF2/SMAD7/PPP2CA/TNF/SMAD3/MICOS10-NBL1/ID4/ACVR2A/SMAD6/ID3/TGFB1/NEO1/BAMBI/NODAL/SMURF1/BMP4/GREM2	44
KEGG	hsa04962	Vasopressin-regulated water reabsorption	22/3289	44/8135	0.127	0.4464	0.3841	DCTN4/DYNC1LI1/RAB11A/DYNC2LI1/CREB1/RAB5A/PRKACB/GNAS/CREB3L4/DCTN6/RAB5C/CREB5/CREB3/NSF/STX4/RAB11B/RAB5B/DYNLL2/CREB3L1/ADCY3/DCTN5/DCTN2	22
KEGG	hsa00220	Arginine biosynthesis	12/3289	22/8135	0.1291	0.449	0.3863	ARG1/ABHD14A-ACY1/GLS/GOT1/ACY1/GPT/ASL/GOT2/ASS1/GLUD1/OTC/GLS2	12
KEGG	hsa05165	Human papillomavirus infection	144/3289	331/8135	0.1344	0.4628	0.3982	PPP2R5E/ITGA4/EGF/RBL1/ATP6V1C1/PRKCI/CASP3/ITGB1/CCND1/HDAC2/EIF2AK2/PSMC1/FN1/ATM/PIK3CA/AXIN2/RBL2/CCNE2/CHUK/DLG1/ATP6V1H/PPP2R5A/RB1/TBK1/FAS/PIK3CB/COL9A2/SOS2/PTEN/MAML2/ATR/EIF4EBP1/FZD6/CREB1/APC/PIK3R1/PRKACB/DVL3/RFNG/PPP2R3C/PPP2R1B/CSNK1A1L/CDC42/ATP6V1A/COL6A3/ITGA1/AKT3/PIK3R3/AXIN1/COL6A1/GNAS/IKBKB/MDM2/IFNAR1/GRB2/VTN/CREB3L4/WNT10A/ITGA2/FZD3/FZD7/THBS1/NRAS/MAP2K1/ATP6V1G2/THBS4/ATP6V0D1/LAMC1/ATP6V0A1/PARD6B/PPP2R3A/EP300/SOS1/TLR3/HES6/ATP6V1G1/CREB5/ATP6V1F/OASL/TCF7/TNR/PRKCZ/CDK4/ITGA9/TP53/FOXO1/PPP2CA/ATP6V0B/TNF/AKT2/PIK3CD/GSK3B/STAT1/CCND2/PARD6A/NFX1/UBE3A/ATP6V1D/CSNK1A1/CREB3/CDK6/KRAS/PPP2R2A/WNT7B/ATP6V0A2/IFNB1/NOTCH4/TNN/PSEN1/TYK2/HES1/WNT5B/LAMA3/PDGFRB/SLC9A3R1/PXN/ATP6V1C2/BAK1/APC2/AKT1/WNT10B/CRB3/CHAD/DVL1/ITGAV/HRAS/ATP6V1B2/VEGFA/COL6A5/CREB3L1/WNT3/MAGI1/COL4A2/IFNA21/BCAP31/CCNE1/CDKN1B/COL1A2/CCNA1/ITGB4/COL9A3/ATP6AP1/MFNG/DVL2	144
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	204/3289	476/8135	0.1438	0.4891	0.4208	PIK3R4/NDUFS1/CASP3/PSMC6/MFN1/NDUFA5/DCTN4/FIG4/ITPR2/ATG2B/OPTN/PSMC1/PSMA3/COX7A2/AXIN2/SPG11/KIF5B/PSMD12/SDHC/TBK1/FAS/PPP3R1/PIK3C3/NDUFC1/FZD6/BCL2/RAB5A/ATXN3/APC/PSMA2/RAB1A/AGER/DVL3/NDUFA9/ALS2/PSMD6/SNCA/SLC25A4/PSMB2/PSMA4/CSNK1A1L/EIF2S1/CHMP2B/CSNK2A2/COX6B1/WDR41/RAB39B/SOD1/C9orf72/DNAH14/COX4I2/CALM3/MAP2K6/CSNK2B/UQCR10/AXIN1/ZFYVE1/ATXN1/UBE2J1/PSMD1/UBE2G2/PPP3CC/VDAC1/PSMB5/PSMD7/KLC3/PLCB1/PSMC2/COX8A/COX6B2/GNAQ/NDUFB3/DNAH7/TUBB/NDUFS7/WNT10A/UCHL1/ATG101/FZD3/HSD17B10/FZD7/DCTN6/MAP1LC3B/UBE2L6/CASP9/CYC1/PSMD14/UQCRB/TOMM40/NRAS/MAP2K1/TANK/ATF6/GPX3/NDUFA11/GRIA4/VAPB/GPX1/PSMC3/COX5A/PSEN2/MAPK9/NDUFA13/MCU/CDK5R1/ULK1/ATP5MC1/NDUFB6/TNF/NOX1/GSK3B/RAB8A/UQCR11/NDUFV2/UQCRC2/CAMK2G/COX6C/ADRM1/ITPR1/CALM1/PSMC4/COX5B/TUBB4B/PPIF/CSNK1A1/NDUFS4/DNAH3/LRRK2/NDUFB5/UQCRQ/PSMA8/PSMA7/TUBB8/KRAS/GRIA1/WNT7B/GPX7/ACTR1B/DNAH1/NDUFV3/DNAH8/COX7A2L/PSMD2/SPTBN2/GPX6/CSNK2A1/CACNA1F/NRBF2/NDUFA2/PSEN1/COX7A1/DCTN3/WIPI2/WNT5B/RB1CC1/UQCRC1/PSMD13/GPX2/COX4I1/UBE2J2/NDUFC2-KCTD14/PLCB2/DAXX/PLCB4/BAK1/SLC25A6/PSMA6/ATP5MC2/ATP5PB/PSMD9/DNAI1/MFN2/ATP5MC3/APC2/ACTR10/NDUFB2/PSMB7/LRP6/ULK2/NDUFAB1/WNT10B/ATXN2L/DVL1/HRAS/UBA1/WNT3/DNAH10/ATG13/PRKCB/HTRA2/CAMK2D/UQCRH/UQCRHL/TNFRSF1B/ATP5PF/RPS27A/GRIN2B/PSMD8/COX7B/NDUFS8/DVL2/ATP5F1D/DCTN5/DCTN2	204
KEGG	hsa04137	Mitophagy - animal	34/3289	72/8135	0.145	0.4891	0.4208	TBC1D15/MFN1/FUNDC1/OPTN/TAX1BP1/TBK1/RHOT1/HIF1A/FOXO3/MITF/GABARAP/CALCOCO2/CSNK2A2/MRAS/USP15/CSNK2B/MAP1LC3B/NRAS/RRAS/FIS1/MAPK9/TFEB/TP53/ULK1/USP8/KRAS/RAB7A/BCL2L13/CSNK2A1/MFN2/HRAS/RPS27A/TBC1D17/BNIP3L	34
KEGG	hsa00620	Pyruvate metabolism	23/3289	47/8135	0.1487	0.49	0.4216	DLD/GLO1/LDHD/ME2/ACAT1/ADH1A/ME1/GRHPR/ACYP2/PDHB/ADH6/ACSS1/ACAT2/ALDH7A1/AKR1A1/MDH1/DLAT/PCK2/ADH5/ACSS2/ALDH2/PDHA1/MDH2	23
KEGG	hsa04919	Thyroid hormone signaling pathway	55/3289	121/8135	0.1489	0.49	0.4216	NCOA1/MED13/CCND1/HDAC2/PIK3CA/MED14/TBC1D4/PIK3CB/MED4/PFKFB2/HIF1A/KAT2B/PIK3R1/PRKACB/NCOR1/AKT3/PIK3R3/NCOA3/MDM2/PLCB1/RXRA/CASP9/NRAS/MAP2K1/PDPK1/MYH7/EP300/THRB/NCOA2/TP53/MED1/FOXO1/AKT2/PIK3CD/GSK3B/STAT1/KRAS/PLCD3/MED13L/NOTCH4/PLN/ATP1A2/ACTG1/PLCZ1/PLCB2/PLCB4/ATP1A3/SLC9A1/AKT1/ITGAV/HRAS/SLC16A2/PRKCB/BMP4/ATP1A4	55
KEGG	hsa03250	Viral life cycle - HIV-1	30/3289	63/8135	0.1497	0.49	0.4216	NUP153/MLLT3/PSIP1/APOBEC3C/RANBP2/XPO1/KAT2B/VPS4B/ELL2/CCNT2/PDCD6IP/APOBEC3D/SERINC5/NELFE/MAP1S/EP300/APOBEC3H/BICD2/MLLT1/MAP1A/APOBEC3F/APOBEC3A/HGS/RAN/APOBEC3B/NELFB/APOBEC3G/SUPT4H1/PIN1/TRIM5	30
KEGG	hsa00350	Tyrosine metabolism	18/3289	36/8135	0.158	0.5076	0.4367	GSTZ1/MIF/IL4I1/GOT1/TAT/ADH1A/ALDH3A1/LRTOMT/GOT2/ADH6/HGD/ALDH3B2/PNMT/ADH5/COMT/MAOB/TYRP1/FAH	18
KEGG	hsa03030	DNA replication	18/3289	36/8135	0.158	0.5076	0.4367	RPA4/PRIM1/DNA2/RFC1/POLE2/RFC2/RNASEH2A/RFC3/RFC5/RPA1/MCM6/POLD2/RPA2/RNASEH2C/POLA2/RNASEH1/MCM3/FEN1	18
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	59/3289	131/8135	0.1602	0.5076	0.4368	IFNGR1/CASP3/PIK3CA/TNFSF10/FAS/PPP3R1/PIK3CB/SOS2/KLRK1/HCST/FCGR3B/PIK3R1/RAC2/GZMB/KIR3DL2/PIK3R3/TYROBP/SHC4/NCR3/PPP3CC/IFNAR1/ITGAL/GRB2/NRAS/MAP2K1/FCER1G/RAET1G/PAK1/FYN/SOS1/LCP2/ICAM2/SH2D1B/KLRC4-KLRK1/CD48/RAET1L/TNF/PIK3CD/KIR2DS4/NCR1/FCGR3A/KRAS/RAC3/KIR3DL1/IFNB1/CD244/KIR3DL3/MICB/VAV2/KIR2DL1/NFATC2/KIR2DL3/PTPN11/PTPN6/HRAS/PRKCB/IFNA21/ICAM1/TNFRSF10A	59
KEGG	hsa04662	B cell receptor signaling pathway	38/3289	82/8135	0.1627	0.5076	0.4368	PIK3CA/CHUK/PPP3R1/PIK3CB/SOS2/PIK3R1/DAPP1/NFATC3/RAC2/LILRA4/AKT3/PIK3R3/RASGRP3/PPP3CC/IKBKB/NFKBIE/GRB2/NRAS/MAP2K1/MALT1/LILRB5/SOS1/LILRA5/LYN/BLNK/CD72/AKT2/PIK3CD/GSK3B/KRAS/RAC3/LILRA2/VAV2/NFATC2/AKT1/PTPN6/HRAS/PRKCB	38
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	41/3289	89/8135	0.1632	0.5076	0.4368	EGF/IFNGR1/PIK3CA/CHUK/JAK2/TLR2/PDCD1/PPP3R1/PIK3CB/PTEN/PRKCQ/TLR4/HIF1A/PIK3R1/NFATC3/EML4/CSNK2A2/AKT3/MAP2K6/CSNK2B/PIK3R3/PPP3CC/IKBKB/NFKBIE/RASGRP1/BATF2/NRAS/MAP2K1/AKT2/PIK3CD/STAT1/MYD88/KRAS/CSNK2A1/NFATC2/AKT1/CD3E/PTPN11/PTPN6/HRAS/CD274	41
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	64/3289	143/8135	0.1641	0.5076	0.4368	KAT6A/BMI1/COMMD3-BMI1/INHBA/SMAD4/PIK3CA/AXIN2/JAK2/BMPR2/PIK3CB/TBX3/FZD6/APC/PIK3R1/PCGF6/DVL3/ACVR1B/SMARCAD1/PCGF2/SMAD2/AKT3/RIF1/SKIL/PIK3R3/AXIN1/REST/GRB2/SMAD5/POU5F1/IL6ST/WNT10A/FZD3/FZD7/NRAS/MAP2K1/LEFTY1/TCF7/ACVR2B/HESX1/AKT2/PIK3CD/GSK3B/SMAD3/FGFR1/JAK3/TCF3/KRAS/ID4/WNT7B/FGF2/ACVR2A/ID3/DUSP9/WNT5B/APC2/AKT1/WNT10B/DVL1/HRAS/ZFHX3/WNT3/NODAL/DVL2/BMP4	64
KEGG	hsa01200	Carbon metabolism	52/3289	115/8135	0.1689	0.5177	0.4454	HIBCH/RPEL1/SDHC/DLD/MCEE/PHGDH/FBP1/ME2/PRPS2/SUCLA2/ACOX3/SUCLG2/ESD/SDSL/ACAT1/GOT1/GLDC/TPI1/ALDH6A1/ACO2/TKFC/IDH1/ME1/PCCA/H6PD/PCCB/AMT/PGP/PGAM2/GPT/PGK1/PDHB/GOT2/ACSS1/ACAT2/ACO1/MDH1/DLAT/SHMT1/ADH5/IDH3A/GCSH/PRPS1/ACSS2/GLUD1/HK1/IDH3B/PDHA1/HAO2/HK2/RPIA/MDH2	52
KEGG	hsa05219	Bladder cancer	20/3289	41/8135	0.1752	0.5319	0.4576	EGF/CCND1/RPS6KA5/RB1/DAPK1/MDM2/THBS1/NRAS/MAP2K1/CDK4/TP53/RASSF1/DAPK2/KRAS/CXCL8/HRAS/VEGFA/CDKN2A/E2F3/E2F2	20
KEGG	hsa00640	Propanoate metabolism	16/3289	32/8135	0.1772	0.5331	0.4586	HIBCH/DLD/ECHDC1/MCEE/DBT/SUCLA2/ACOX3/SUCLG2/ALDH6A1/PCCA/ABAT/HADHA/PCCB/BCKDHA/ACSS1/ACSS2	16
KEGG	hsa05020	Prion disease	118/3289	273/8135	0.1855	0.5532	0.476	NDUFS1/CASP3/PSMC6/NDUFA5/ITPR2/PSMC1/PSMA3/COX7A2/PIK3CA/KIF5B/PSMD12/SDHC/PPP3R1/PIK3CB/NDUFC1/CREB1/PIK3R1/PSMA2/PRKACB/NDUFA9/PSMD6/RAC2/SLC25A4/PSMB2/PSMA4/EIF2S1/CSNK2A2/COX6B1/SOD1/COX4I2/CSNK2B/PIK3R3/UQCR10/PSMD1/PPP3CC/HSPA6/VDAC1/PSMB5/PSMD7/KLC3/PSMC2/COX8A/COX6B2/CREB3L4/NDUFB3/TUBB/NDUFS7/HSPA1L/CASP9/CYC1/PSMD14/UQCRB/LAMC1/NDUFA11/FYN/CREB5/PSMC3/COX5A/MAPK9/NDUFA13/MCU/ATP5MC1/NDUFB6/TNF/PIK3CD/GSK3B/UQCR11/NDUFV2/UQCRC2/COX6C/ADRM1/ITPR1/PSMC4/COX5B/TUBB4B/PPIF/NDUFS4/CREB3/NDUFB5/UQCRQ/PSMA8/PSMA7/TUBB8/C1QA/NDUFV3/COX7A2L/PSMD2/CSNK2A1/CACNA1F/NDUFA2/COX7A1/UQCRC1/PSMD13/CYBA/COX4I1/NDUFC2-KCTD14/SLC25A6/PSMA6/ATP5MC2/ATP5PB/PSMD9/ATP5MC3/NDUFB2/PSMB7/NDUFAB1/CREB3L1/GRIN3B/UQCRH/UQCRHL/ATP5PF/GRIN2B/PSMD8/COX7B/NDUFS8/CAV1/ATP5F1D/HSPA1B/NCF2	118
KEGG	hsa04380	Osteoclast differentiation	57/3289	128/8135	0.1939	0.5732	0.4932	IFNGR1/MAP3K7/PIK3CA/CHUK/PPP3R1/PIK3CB/MITF/FCGR3B/CREB1/TAB2/PIK3R1/TGFB2/TEC/CYLD/LILRA4/AKT3/TNFRSF11B/MAP2K6/PIK3R3/TYROBP/PPP3CC/IKBKB/IFNAR1/GRB2/MAP2K1/LILRB5/FYN/LCP2/MAPK9/LILRA5/BLNK/TNF/CTSK/SOCS3/AKT2/PIK3CD/NOX1/STAT1/JUND/FCGR3A/CSF1R/FOSB/SIRPB1/IFNB1/LILRA2/TYK2/ACP5/CYBA/TAB1/TGFB1/JUNB/NFATC2/RELB/AKT1/GAB2/OSCAR/NCF2	57
KEGG	hsa04922	Glucagon signaling pathway	48/3289	107/8135	0.1998	0.5854	0.5036	PPP4R3A/PHKB/PRKAA1/GYS2/ITPR2/PPP4R3B/PPP3R1/PDE3B/CREB1/FBP1/PRKACB/SIRT1/AKT3/CALM3/PPP3CC/GNAS/PRKAB1/PLCB1/CREB3L4/GNAQ/CPT1C/PHKG2/EP300/CPT1A/CREB5/PRKAG1/FOXO1/G6PC3/AKT2/PPP4C/CAMK2G/ITPR1/CALM1/PRKAG3/CREB3/PGAM2/PDHB/SIK2/PLCB2/PLCB4/ADCY2/AKT1/PCK2/CREB3L1/CAMK2D/PDHA1/PHKA1/PRMT1	48
KEGG	hsa05170	Human immunodeficiency virus 1 infection	92/3289	212/8135	0.2055	0.5887	0.5065	CUL4B/CASP3/MAP3K7/ITPR2/GNGT2/ATM/PIK3CA/CHUK/TLR2/CDK1/CUL5/GNG10/AP1G1/APOBEC3C/TBK1/FAS/PPP3R1/PIK3CB/ATR/TLR4/TRAF5/CUL1/BCL2/TAB2/PIK3R1/NFATC3/IRAK4/RAC2/GNG5/SKP1/AKT3/CALM3/MAP2K6/CUL4A/AP1S2/PIK3R3/PPP3CC/IKBKB/TAP2/GNAQ/NFATC4/TAPBP/CASP9/ELOC/APOBEC3D/ELOB/NRAS/MAP2K1/CCNB2/GNB3/PAK1/AP1M1/CRKL/MAPK9/APOBEC3H/TNF/AKT2/PIK3CD/ITPR1/CALM1/MYD88/KRAS/GNB4/RAC3/GNB1/IFNB1/CHEK1/APOBEC3F/APOBEC3A/GNA11/TAB1/GNG11/PAK6/PXN/BAK1/RNF7/DDB1/NFATC2/AKT1/CD3E/APOBEC3B/CFL2/HRAS/BUB1B-PAK6/RIPK1/PRKCB/TNFRSF1B/IFNA21/APOBEC3G/CFL1/PAK4/TRIM5	92
KEGG	hsa04530	Tight junction	74/3289	169/8135	0.2059	0.5887	0.5065	PRKAA1/PRKCI/ITGB1/CCND1/CD1C/HSPA4/RAB8B/DLG1/ACTR3/ACTR2/ROCK1/RUNX1/PRKACB/PPP2R1B/CD1B/MYL12A/CDC42/ROCK2/CD1E/WAS/RAP1A/PRKAB1/RAP2C/NEDD4/ACTN4/CLDN2/ARPC3/YBX3/ARPC4/EZR/CD1D/ARPC1A/CLDN6/ACTR3C/MAP3K1/CLDN17/RAPGEF2/PARD6B/PRKAG1/MAPK9/ARHGEF2/PRKCZ/CDK4/PPP2CA/ACTR3B/MICALL2/RAB8A/PARD6A/TIAM1/PRKAG3/CLDN14/ARPC2/PPP2R2A/PRKCE/CLDN4/NF2/CD1A/CLDN19/ACTG1/SLC9A3R1/CFTR/MYL6B/ARPC5/CLDN11/JAM3/CRB3/MAGI1/RAPGEF6/CTTN/MYL12B/ARPC5L/MYL9/OCLN/MSN	74
KEGG	hsa05145	Toxoplasmosis	50/3289	112/8135	0.2062	0.5887	0.5065	BIRC3/HLA-DMB/IFNGR1/CASP3/ITGB1/MAP3K7/BIRC2/CHUK/JAK2/TLR2/HLA-DRA/HLA-DMA/TLR4/BCL2/TAB2/TGFB2/LY96/IRAK4/XIAP/AKT3/MAP2K6/HLA-DOA/HSPA6/IKBKB/HLA-DQA1/HLA-DQA2/CD40LG/HSPA1L/CASP9/PDPK1/LAMC1/MAPK9/PIK3R5/TNF/AKT2/STAT1/CD40/MYD88/HLA-DPA1/PPIF/HLA-DQB1/IL10RA/TYK2/LAMA3/TAB1/BIRC7/TGFB1/AKT1/LDLR/HSPA1B	50
KEGG	hsa04925	Aldosterone synthesis and secretion	44/3289	98/8135	0.2103	0.5954	0.5122	ITPR2/ATF1/PRKD3/ATP2B1/CREB1/PRKACB/CAMK1D/CALM3/GNAS/PLCB1/CREB3L4/GNAQ/KCNK9/POMC/PDE2A/CREB5/CACNA1I/ADCY5/NPR1/CAMK2G/ITPR1/CALM1/CREB3/CYP11A1/NR4A2/PRKCE/CACNA1F/GNA11/HSD3B2/ATP1A2/PLCB2/PLCB4/ADCY2/ATP1A3/CACNA1G/SCARB1/NPPA/CREB3L1/PRKCB/CAMK2D/LIPE/ADCY3/ATP1A4/LDLR	44
KEGG	hsa04211	Longevity regulating pathway	40/3289	89/8135	0.2217	0.6187	0.5323	PRKAA1/PIK3CA/PIK3CB/EIF4EBP1/FOXO3/CREB1/PIK3R1/PRKACB/SIRT1/APPL1/AKT3/PIK3R3/PRKAB1/SESN3/CREB3L4/ATG101/EIF4E1B/NRAS/EIF4E2/CREB5/PRKAG1/TP53/ULK1/ADCY5/FOXO1/AKT2/PIK3CD/SESN1/PRKAG3/CREB3/KRAS/ADIPOR1/RB1CC1/ADCY2/AKT1/HRAS/CREB3L1/ATG13/SESN2/ADCY3	40
KEGG	hsa04931	Insulin resistance	48/3289	108/8135	0.2238	0.6187	0.5323	GFPT1/RPS6KA3/PRKAA1/GYS2/OGA/PIK3CA/SLC27A2/TBC1D4/PPP1CB/PIK3CB/PPP1CC/PTEN/NR1H3/PRKCQ/CREB1/PIK3R1/AKT3/MLX/PIK3R3/IKBKB/PRKAB1/CREB3L4/PDPK1/SREBF1/OGT/CPT1A/CREB5/PRKAG1/MAPK9/PRKCZ/FOXO1/TNF/SOCS3/G6PC3/AKT2/PIK3CD/GSK3B/PRKAG3/CREB3/PTPA/PRKCE/PPP1R3B/AKT1/PTPN11/PCK2/CREB3L1/PRKCB/SLC27A3	48
KEGG	hsa05162	Measles	61/3289	139/8135	0.226	0.6187	0.5323	IFIH1/DDX58/CASP3/MAP3K7/CCND1/EIF2AK2/PIK3CA/CD46/CCNE2/CHUK/TLR2/TBK1/FAS/EIF3H/PIK3CB/OAS1/TLR4/BCL2/TAB2/PIK3R1/RCHY1/IRAK4/EIF2S1/CSNK2A2/AKT3/CSNK2B/PIK3R3/HSPA6/IKBKB/IFNAR1/STAT5B/HSPA1L/CASP9/OAS2/MAPK9/CDK4/TP53/IL2RG/AKT2/PIK3CD/GSK3B/STAT1/CCND2/MYD88/JAK3/CDK6/TP73/IFNB1/CSNK2A1/TYK2/CBLB/BAK1/AKT1/CD3E/SLAMF1/STAT5A/IFNA21/CCNE1/CDKN1B/HSPA1B/MSN	61
KEGG	hsa05418	Fluid shear stress and atherosclerosis	61/3289	139/8135	0.226	0.6187	0.5323	PRKAA1/SUMO1/MAP3K7/PIK3CA/HSP90B1/CHUK/GSTA1/BMPR2/PIK3CB/BCL2/PIK3R1/KLF2/RAC2/TXN2/AKT3/CALM3/MAP2K6/PIK3R3/IKBKB/PDGFA/TXN/MAPK7/MAPK9/ARHGEF2/PRKCZ/ACVR2B/TP53/GSTA5/TNF/MEF2A/AKT2/PIK3CD/NOX1/CALM1/MEF2C/RAC3/ACVR2A/CCL2/HMOX1/NFE2L2/SUMO2/KDR/CYBA/ACTG1/VCAM1/AKT1/ITGAV/VEGFA/ASS1/NQO1/GSTA3/SUMO3/IL1R2/PECAM1/ICAM1/GSTP1/CTSL/KEAP1/BMP4/CAV1/NCF2	61
KEGG	hsa04910	Insulin signaling pathway	60/3289	137/8135	0.2345	0.6368	0.5479	PHKB/PRKAA1/PRKCI/GYS2/PIK3CA/RPS6/PRKAR1A/PPP1CB/PRKAR2B/PIK3CB/PPP1CC/SOS2/EIF4EBP1/PDE3B/PIK3R1/FBP1/PRKACB/AKT3/CALM3/PIK3R3/SHC4/IKBKB/PRKAB1/GRB2/SOCS4/PHKG2/EIF4E1B/NRAS/MAP2K1/PDPK1/SREBF1/PRKAR2A/MKNK2/SOS1/EIF4E2/PRKAG1/CRKL/MAPK9/PRKCZ/FOXO1/SOCS3/G6PC3/AKT2/PIK3CD/GSK3B/CALM1/PRKAG3/KRAS/PPP1R3B/CBLB/AKT1/PCK2/HRAS/SORBS1/LIPE/FLOT2/HK1/TRIP10/HK2/PHKA1	60
KEGG	hsa03022	Basal transcription factors	21/3289	45/8135	0.2398	0.646	0.5558	GTF2H2/TAF2/TAF5/GTF2H2C/TAF1L/MNAT1/GTF2F2/GTF2H1/TAF9/TAF9B/CDK7/TAF7/TAF10/GTF2IRD1/TAF6L/TAF12/TAF13/TAF3/TAF4B/GTF2H4/TAF8	21
KEGG	hsa04625	C-type lectin receptor signaling pathway	46/3289	104/8135	0.2428	0.6481	0.5576	ITPR2/CASP1/PIK3CA/CHUK/ARHGEF12/CLEC1B/PPP3R1/PIK3CB/MAPKAPK2/PIK3R1/CYLD/NFATC3/AKT3/CALM3/MRAS/PIK3R3/PPP3CC/IKBKB/MDM2/NFATC4/NRAS/CARD9/RRAS/FCER1G/MALT1/CCL22/PAK1/MAPK9/TNF/AKT2/PIK3CD/PYCARD/STAT1/CLEC4D/CLEC6A/ITPR1/CALM1/KRAS/CLEC4E/CBLB/NFATC2/RELB/AKT1/PTPN11/HRAS/BCL3	46
KEGG	hsa04070	Phosphatidylinositol signaling system	43/3289	97/8135	0.2462	0.6481	0.5576	SACM1L/MTMR2/ITPR2/PIK3CA/IPMK/MTMR6/PIK3CB/PIK3C3/PTEN/PPIP5K2/PIK3R1/PIKFYVE/DGKE/PI4K2B/INPP5F/CALM3/PIK3R3/PIK3C2A/DGKA/PLCB1/SYNJ2/INPP1/PIP4K2C/INPP5E/SYNJ1/PIK3CD/PI4K2A/DGKK/ITPR1/CALM1/MTMR8/PLCD3/PIP5K1C/INPP4B/PLCZ1/PLCB2/PLCB4/PIP4P2/PIP4K2A/CDS2/ITPKC/PRKCB/ITPKB	43
KEGG	hsa00230	Purine metabolism	56/3289	128/8135	0.2472	0.6481	0.5576	PGM2/GUCY1B1/PPAT/NME7/AK6/AK3/PDE3B/RRM2B/AK9/URAD/ADK/ADA/PRPS2/DCK/PGM1/XDH/AK1/NME1/ENTPD6/ENPP4/NTPCR/NPR2/PDE4C/NUDT9/ADA2/AMPD2/ADPRM/PDE2A/NUDT2/NME6/HDDC3/NT5C1B/HPRT1/PDE3A/PAPSS1/GMPR/ADCY5/CANT1/NPR1/GUCY1A1/AK8/ENTPD8/GMPS/NT5C1A/NT5C2/ADCY2/PDE6G/PAICS/GMPR2/NUDT5/PRPS1/AK4/ADCY3/PDE8A/ENTPD4/RRM1	56
KEGG	hsa00500	Starch and sucrose metabolism	17/3289	36/8135	0.2523	0.6481	0.5576	UGP2/PGM2/GYS2/AMY1A/AMY1B/AMY1C/AGL/GYG2/GANC/AMY2A/PGM1/MGAM/G6PC3/GBE1/PGM2L1/HK1/HK2	17
KEGG	hsa00512	Mucin type O-glycan biosynthesis	17/3289	36/8135	0.2523	0.6481	0.5576	GALNT3/GALNT7/ST6GALNAC4/B3GNT3/C1GALT1/GCNT4/ST6GALNAC1/GALNT4/POC1B-GALNT4/GALNT10/GALNT1/C1GALT1C1/B4GALT5/GALNT11/GALNT14/B3GNT6/GALNT8	17
KEGG	hsa00071	Fatty acid degradation	20/3289	43/8135	0.2534	0.6481	0.5576	ACADM/ACSL3/ACSL4/ACOX3/ACSL5/ACAT1/ACADSB/CPT1C/ADH1A/ACSL1/HADHA/CPT1A/HADH/ADH6/ACAT2/ALDH7A1/HADHB/ADH5/ALDH2/ACAA2	20
KEGG	hsa00670	One carbon pool by folate	10/3289	20/8135	0.2572	0.6481	0.5576	MTHFD1/ALDH1L2/MTR/MTFMT/ST20-MTHFS/MTHFD2L/TYMS/AMT/MTHFR/SHMT1	10
KEGG	hsa04022	cGMP-PKG signaling pathway	72/3289	167/8135	0.262	0.6481	0.5576	ITPR2/GUCY1B1/RGS2/GNA13/KCNMB3/PPP1CB/ROCK1/PPP3R1/PPP1CC/ATP2B1/PDE3B/CREB1/ADRA2A/NFATC3/SLC25A4/ADRB2/ROCK2/AKT3/CALM3/GNA12/PPP3CC/NPR2/KCNMB4/VDAC1/PLCB1/CREB3L4/GNAQ/NFATC4/SLC8A2/MAP2K1/PDE2A/MYH7/SRF/CREB5/GTF2IRD1/PIK3R5/PDE3A/ADCY5/ADORA3/MEF2A/AKT2/KNG1/NPR1/ITPR1/CALM1/PPIF/MEF2C/CREB3/GUCY1A1/PRKCE/CACNA1F/PPP1R12A/SLC8A3/PLN/GNA11/ADRA2C/ATP1A2/PLCB2/PLCB4/ADCY2/ATP1A3/SLC25A6/NFATC2/PRKG2/AKT1/NPPA/CREB3L1/EDNRB/ADCY3/ADRA2B/ATP1A4/MYL9	72
KEGG	hsa04213	Longevity regulating pathway - multiple species	28/3289	62/8135	0.2622	0.6481	0.5576	PRKAA1/HDAC2/PIK3CA/PIK3CB/FOXO3/PIK3R1/PRKACB/SIRT1/SOD1/AKT3/PIK3R3/HSPA6/PRKAB1/HSPA1L/NRAS/PRKAG1/EIF4EBP2/ADCY5/FOXO1/AKT2/PIK3CD/PRKAG3/KRAS/ADCY2/AKT1/HRAS/ADCY3/HSPA1B	28
KEGG	hsa04966	Collecting duct acid secretion	13/3289	27/8135	0.2648	0.6481	0.5576	ATP6V1C1/ATP6V1A/ATP6V1G2/ATP6V0D1/ATP6V0A1/ATP6V1G1/ATP6V1F/SLC4A1/ATP6V1D/ATP6V0A2/ATP4A/ATP6V1C2/ATP6V1B2	13
KEGG	hsa05163	Human cytomegalovirus infection	96/3289	225/8135	0.2654	0.6481	0.5576	CASP3/CCND1/ITPR2/GNGT2/PIK3CA/CHUK/ARHGEF12/RB1/GNA13/GNG10/ROCK1/TBK1/FAS/PPP3R1/PIK3CB/SOS2/EIF4EBP1/TRAF5/CREB1/PIK3R1/PRKACB/NFATC3/RAC2/GNG5/ROCK2/AKT3/CALM3/GNA12/MAP2K6/PIK3R3/PPP3CC/GNAS/IKBKB/MDM2/PDGFRA/CCL4L2/CCL4/GRB2/PLCB1/TAP2/CREB3L4/GNAQ/NFATC4/TAPBP/CCL3L1/CASP9/NRAS/MAP2K1/GNB3/SOS1/CREB5/CRKL/CDK4/AKAP13/TP53/ADCY5/TNF/AKT2/PIK3CD/GSK3B/CCL3/ITPR1/CALM1/CREB3/CDK6/KRAS/GNB4/RAC3/GNB1/IFNB1/CCL2/IL10RA/IL6R/GNA11/CXCL8/CXCR2/GNG11/PLCB2/PXN/PLCB4/ADCY2/BAK1/NFATC2/AKT1/ITGAV/HRAS/VEGFA/CREB3L1/RIPK1/PRKCB/IFNA21/CDKN2A/ADCY3/E2F3/E2F2/BCAR1	96
KEGG	hsa04210	Apoptosis	59/3289	136/8135	0.2668	0.6481	0.5576	BIRC3/CASP3/CTSO/ITPR2/BIRC2/ATM/PIK3CA/TNFSF10/CHUK/PTPN13/FAS/PIK3CB/PARP4/BCL2/PIK3R1/CASP6/LMNA/DFFA/GZMB/XIAP/PARP2/EIF2S1/AKT3/PIK3R3/CFLAR/IKBKB/CASP9/CTSH/NRAS/MAP2K1/PDPK1/CTSC/MAPK9/TP53/GADD45B/TNF/CTSK/AKT2/PIK3CD/LMNB1/ITPR1/CTSD/PARP3/KRAS/PARP1/ACTG1/DAXX/BAK1/MCL1/AKT1/BCL2L11/CTSZ/HRAS/RIPK1/HTRA2/IL3RA/CTSL/BIRC5/TNFRSF10A	59
KEGG	hsa01240	Biosynthesis of cofactors	66/3289	153/8135	0.2714	0.6481	0.5576	UGP2/KMO/VKORC1L1/DLD/NME7/AK6/AK3/PPCDC/MTHFD1/KYNU/AK9/PANK3/BCAT2/PNPO/AK1/NME1/COQ6/GGH/RDH11/NMNAT1/HMBS/TPK1/PHOSPHO2/HAAO/MTHFD2L/CMPK2/COQ7/NME6/UROS/PTS/QPRT/DHODH/LIPT2/LIAS/ALAD/MAT1A/CMPK1/COQ2/ALAS2/VKORC1/GMPPB/PMM2/SPR/MAT2B/CTPS1/AK8/FLAD1/NADK2/CAD/COQ5/NMNAT3/AKR1A1/FPGS/NAPRT/ALPL/SHMT1/HSD17B6/COX15/GSS/NQO1/AK4/ALDH2/RDH13/UGT1A3/UGT2B28/UGT2B11	66
KEGG	hsa04360	Axon guidance	78/3289	182/8135	0.2739	0.6481	0.5576	RYK/NCK1/ITGB1/PIK3CA/ARHGEF12/ROCK1/BMPR2/PPP3R1/MYL5/PIK3CB/SEMA4A/PIK3R1/GDF7/NFATC3/RAC2/MYL12A/CDC42/EPHA2/TRPC1/SRGAP2/SEMA3A/ROCK2/PIK3R3/SEMA3C/PPP3CC/ABLIM1/EPHA4/NFATC4/FZD3/DCC/DPYSL5/NRAS/PDPK1/RRAS/ILK/PARD6B/PAK1/FYN/UNC5B/PRKCZ/EPHA1/PIK3CD/GSK3B/PARD6A/CAMK2G/SEMA4G/SEMA3B/KRAS/RAC3/SEMA3F/RND1/WNT5B/EFNB1/UNC5D/EFNA4/PLXNA3/PAK6/PLXNC1/NEO1/RHOD/NFATC2/SSH1/PTPN11/CFL2/HRAS/BUB1B-PAK6/CAMK2D/SEMA6C/SEMA3E/RGS3/PLXNA2/CFL1/MYL12B/MET/PLXNA4/PLXNB3/MYL9/PAK4	78
KEGG	hsa05231	Choline metabolism in cancer	43/3289	98/8135	0.2743	0.6481	0.5576	EGF/LYPLA1/PIK3CA/GPCPD1/PLA2G4A/PIK3CB/SOS2/EIF4EBP1/HIF1A/PLD1/PIK3R1/RAC2/DGKE/CHPT1/AKT3/WAS/PIK3R3/PDGFRA/WASF1/GRB2/PDGFA/DGKA/NRAS/MAP2K1/PDPK1/WASF3/SOS1/PLPP1/SLC22A4/MAPK9/AKT2/PIK3CD/DGKK/KRAS/RAC3/PIP5K1C/PDGFRB/PLPP3/CHKB/AKT1/HRAS/PRKCB/SLC44A2	43
KEGG	hsa05416	Viral myocarditis	27/3289	60/8135	0.2753	0.6481	0.5576	EIF4G3/HLA-DMB/CASP3/CCND1/HLA-DRA/HLA-DMA/RAC2/ABL2/HLA-DOA/HLA-DQA1/CD86/ITGAL/HLA-DQA2/CD40LG/CASP9/MYH7/FYN/CD40/HLA-DPA1/CD55/RAC3/HLA-DQB1/DAG1/ACTG1/SGCA/ICAM1/CAV1	27
KEGG	hsa00061	Fatty acid biosynthesis	9/3289	18/8135	0.2755	0.6481	0.5576	CBR4/ACSL3/ACSL4/ACSL5/HSD17B8/MCAT/MECR/ACSL1/HTD2	9
KEGG	hsa00511	Other glycan degradation	9/3289	18/8135	0.2755	0.6481	0.5576	NEU2/HEXB/MAN2B1/NEU3/GBA/MANBA/NEU1/FUCA1/MAN2C1	9
KEGG	hsa04062	Chemokine signaling pathway	82/3289	192/8135	0.2812	0.6499	0.5591	PPBP/GNGT2/PIK3CA/CHUK/JAK2/GNG10/ROCK1/PIK3CB/SOS2/FOXO3/GRK6/PIK3R1/PRKACB/CXCL5/RAC2/PF4/GNG5/CDC42/ROCK2/CX3CR1/AKT3/WAS/PIK3R3/SHC4/RAP1A/IKBKB/CCL4L2/CCL4/GRB2/PLCB1/GNAQ/ITK/STAT5B/GRK1/CCL3L1/CXCL16/NRAS/MAP2K1/GNB3/CCL18/CCL22/XCL2/PAK1/SOS1/CRKL/PIK3R5/DOCK2/PRKCZ/LYN/ADCY5/CCR6/AKT2/PIK3CD/GRK5/GSK3B/STAT1/CCL3/TIAM1/JAK3/CXCL9/KRAS/GNB4/RAC3/GNB1/CCL2/CXCL3/CXCL8/CXCR2/GNG11/PLCB2/VAV2/PXN/PLCB4/CXCR1/ADCY2/AKT1/GRK4/HRAS/CXCR3/PRKCB/ADCY3/BCAR1	82
KEGG	hsa00513	Various types of N-glycan biosynthesis	18/3289	39/8135	0.2834	0.6499	0.5591	MAN2A1/ALG11/FUT8/STT3B/MGAT4A/MAN1A1/HEXB/MAN1A2/ALG13/ALG1/B4GALT1/MAN1C1/RPN1/ALG3/MAN2A2/CHST8/B4GALT2/STT3A	18
KEGG	hsa04136	Autophagy - other	15/3289	32/8135	0.2841	0.6499	0.5591	PIK3R4/ATG4C/ATG2B/PIK3C3/GABARAP/ATG3/ATG10/ATG101/ATG7/PPP2CA/ATG12/ATG4B/WIPI2/ULK2/ATG13	15
KEGG	hsa04215	Apoptosis - multiple species	15/3289	32/8135	0.2841	0.6499	0.5591	BIRC3/CASP3/BIRC2/BCL2/XIAP/CASP9/MAPK9/BOK/BIRC7/BAK1/BCL2L11/BIRC6/HTRA2/BIRC5/NGFR	15
KEGG	hsa05226	Gastric cancer	64/3289	149/8135	0.2903	0.6573	0.5655	EGF/FGF19/CCND1/SMAD4/PIK3CA/AXIN2/CCNE2/RB1/PIK3CB/SOS2/FZD6/BCL2/APC/PIK3R1/TGFB2/DVL3/POLK/CSNK1A1L/SMAD2/AKT3/JUP/ABCB1/PIK3R3/AXIN1/SHC4/GRB2/RXRA/WNT10A/FZD3/FZD7/NRAS/MAP2K1/SOS1/TERC/TCF7/TP53/GADD45B/AKT2/PIK3CD/GSK3B/SMAD3/CSNK1A1/FGF10/KRAS/WNT7B/FGF2/MLH1/WNT5B/TGFB1/GAB1/BAK1/APC2/LRP6/AKT1/WNT10B/DVL1/HRAS/WNT3/CCNE1/CDKN1B/E2F3/E2F2/MET/DVL2	64
KEGG	hsa00270	Cysteine and methionine metabolism	23/3289	51/8135	0.2932	0.6573	0.5655	ENOPH1/APIP/PHGDH/BCAT2/MTR/IL4I1/AMD1/SDSL/CDO1/GOT1/TST/TAT/KYAT3/MAT1A/AHCYL2/MAT2B/AHCY/GOT2/MDH1/SRM/AHCYL1/GSS/MDH2	23
KEGG	hsa05230	Central carbon metabolism in cancer	31/3289	70/8135	0.2936	0.6573	0.5655	FLT3/PIK3CA/PIK3CB/PTEN/HIF1A/PIK3R1/AKT3/PIK3R3/GLS/PDGFRA/NRAS/MAP2K1/IDH1/TP53/AKT2/PIK3CD/SLC7A5/FGFR1/RET/PGAM2/KRAS/PDHB/PDGFRB/AKT1/HRAS/TIGAR/HK1/PDHA1/HK2/MET/GLS2	31
KEGG	hsa00360	Phenylalanine metabolism	8/3289	16/8135	0.2961	0.6573	0.5655	MIF/IL4I1/GOT1/TAT/ALDH3A1/GOT2/ALDH3B2/MAOB	8
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	17/3289	37/8135	0.3	0.6573	0.5655	GFPT1/ASNS/PPAT/IL4I1/GLS/GOT1/ABAT/RIMKLB/GPT/ASL/GOT2/CAD/ASS1/GLUD1/RIMKLA/GLS2/ALDH4A1	17
KEGG	hsa05143	African trypanosomiasis	17/3289	37/8135	0.3	0.6573	0.5655	FAS/HBA1/HBA2/PLCB1/GNAQ/TNF/KNG1/MYD88/HPR/PLCB2/PLCB4/THOP1/VCAM1/NPPA/PRKCB/HBB/ICAM1	17
KEGG	hsa04640	Hematopoietic cell lineage	43/3289	99/8135	0.3035	0.6573	0.5655	ITGA4/FLT3/HLA-DMB/CD1C/HLA-DRA/HLA-DMA/CD44/IL7R/CD1B/IL11RA/ITGA1/THPO/CD1E/TFRC/HLA-DOA/HLA-DQA1/CSF3/HLA-DQA2/EPO/CD1D/ITGA2/EPOR/FCER2/CR1/TNF/HLA-DPA1/CSF1R/CD55/GYPA/IL5RA/MS4A1/HLA-DQB1/CD8A/CD7/IL6R/CD1A/CD37/GP5/CD3E/CSF2RA/CD38/IL1R2/IL3RA	43
KEGG	hsa04340	Hedgehog signaling pathway	25/3289	56/8135	0.3037	0.6573	0.5655	SMURF2/EFCAB7/CCND1/CUL3/KIF3A/CUL1/BCL2/PRKACB/MOSMO/GPR161/CSNK1G3/SPOPL/CSNK1A1L/EVC/PTCH2/CSNK1G1/KIF7/GSK3B/CCND2/IQCE/CSNK1A1/DISP1/SMURF1/CSNK1G2/SUFU	25
KEGG	hsa05417	Lipid and atherosclerosis	91/3289	215/8135	0.3062	0.6573	0.5655	CASP3/MAP3K7/CASP1/HSPA4/PIK3CA/TNFSF10/HSP90B1/CHUK/JAK2/TLR2/TBK1/FAS/PPP3R1/PIK3CB/ERO1A/TLR4/BCL2/TAB2/PIK3R1/CASP6/AGER/NFATC3/LY96/IRAK4/CDC42/EIF2S1/ROCK2/AKT3/CALM3/MAP2K6/PIK3R3/ABCA1/PPP3CC/HSPA6/RAP1A/IKBKB/LBP/PLCB1/CD40LG/RXRA/HSPA1L/CCL3L1/CASP9/NRAS/PDPK1/TANK/ATF6/MAPK9/TP53/LYN/TNF/SELP/AKT2/PIK3CD/NOX1/GSK3B/PYCARD/CCL3/CAMK2G/CD40/ITPR1/CYP2C8/CALM1/MYD88/KRAS/IFNB1/CCL2/CYP2B6/POU2F1/NFE2L2/CXCL3/CXCL8/CYBA/TAB1/PLCB2/VAV2/PLCB4/CYP1A1/VCAM1/NFATC2/AKT1/HRAS/CAMK2D/IFNA21/TLR6/ICAM1/OLR1/LDLR/HSPA1B/NCF2/TNFRSF10A	91
KEGG	hsa05160	Hepatitis C	67/3289	157/8135	0.3084	0.6573	0.5655	EGF/DDX58/CASP3/CCND1/EIF2AK2/PIK3CA/CHUK/RB1/TBK1/FAS/PIK3CB/SOS2/NR1H3/IFIT1/OAS1/YWHAZ/PIK3R1/PPP2R1B/EIF2S1/AKT3/YWHAB/PIK3R3/CFLAR/IKBKB/IFNAR1/GRB2/CLDN2/RXRA/CASP9/CLDN6/OAS2/RSAD2/NRAS/MAP2K1/CLDN17/SOS1/TLR3/CDK4/TP53/PPP2CA/TNF/SOCS3/AKT2/PIK3CD/GSK3B/STAT1/PSME3/CLDN14/CDK6/KRAS/PPP2R2A/IFNB1/CLDN4/EIF3E/TYK2/CLDN19/BAK1/CLDN11/SCARB1/AKT1/HRAS/RIPK1/IFNA21/E2F3/E2F2/OCLN/LDLR	67
KEGG	hsa04630	JAK-STAT signaling pathway	69/3289	162/8135	0.3123	0.6573	0.5655	EGF/IFNGR1/CCND1/PIK3CA/JAK2/STAM2/PIK3CB/SOS2/BCL2/IL7R/PIK3R1/PIAS2/IL11RA/THPO/AKT3/PIK3R3/FHL1/PTPN2/IFNAR1/PDGFRA/CSF3/IFNL3/GRB2/PDGFA/EPO/IL6ST/STAT5B/PIM1/EPOR/SOCS4/IL12RB1/CSH1/EP300/SOS1/IL2RG/SOCS3/AKT2/PIK3CD/STAT1/CCND2/OSM/PIAS3/JAK3/IL15RA/PRL/IL5RA/IFNB1/IL10RA/IL6R/TYK2/STAT4/PDGFRB/STAM/IL22/CSH2/MCL1/AKT1/PTPN11/PTPN6/OSMR/HRAS/STAT5A/IFNA21/CSF2RA/IL3RA/IL19/CTF1/IL21/IL15	69
KEGG	hsa00590	Arachidonic acid metabolism	27/3289	61/8135	0.3131	0.6573	0.5655	PLA2G4A/PLA2G2D/LTA4H/ALOX15B/CYP4F3/PTGES/PTGES3/AKR1C3/CYP2E1/ALOX15/GPX3/CYP4F2/CBR1/GPX1/PTGDS/CYP2C8/ALOX12B/LTC4S/GPX7/CYP2B6/GPX6/PLA2G12A/GPX2/PLA2G2E/PTGS1/PLA2G10/TBXAS1	27
KEGG	hsa00380	Tryptophan metabolism	19/3289	42/8135	0.3135	0.6573	0.5655	KMO/CYP1B1/DLD/KYNU/IL4I1/ACAT1/HAAO/HADHA/KYAT3/HADH/ACAT2/ALDH7A1/AADAT/CYP1A1/MAOB/ALDH2/ACMSD/DHTKD1/ASMT	19
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	47/3289	109/8135	0.3149	0.6573	0.5655	MPHOSPH10/UTP14C/RIOK2/NOP58/GNL3/WDR75/RIOK1/EFL1/NXT2/AK6/UTP15/XPO1/GTPBP4/XRN1/WDR36/NMD3/EIF6/HEATR1/XRN2/WDR43/MDN1/UTP18/CSNK2A2/CSNK2B/NHP2/REXO2/SBDS/POP7/NVL/NXF3/IMP4/RPP25L/BMS1/SPATA5/UTP14A/DROSHA/RBM28/POP4/NXT1/CSNK2A1/SNU13/RMRP/RAN/FCF1/TBL3/EMG1/UTP6	47
KEGG	hsa04722	Neurotrophin signaling pathway	51/3289	119/8135	0.325	0.6742	0.5801	RPS6KA3/KIDINS220/PIK3CA/RPS6KA5/PIK3CB/SOS2/MAPKAPK2/FOXO3/BCL2/PIK3R1/IRAK4/CDC42/AKT3/CALM3/PIK3R3/SHC4/RAP1A/IKBKB/NFKBIE/GRB2/MAPK7/MAP3K1/NRAS/MAP2K1/PDPK1/BEX3/SOS1/CRKL/IRAK2/PSEN2/MAPK9/TP53/NTF4/AKT2/PIK3CD/GSK3B/RIPK2/CAMK2G/CALM1/KRAS/TP73/PSEN1/GAB1/AKT1/PTPN11/HRAS/MAGED1/CAMK2D/SH2B3/FRS2/NGFR	51
KEGG	hsa00600	Sphingolipid metabolism	23/3289	52/8135	0.3353	0.689	0.5928	ASAH1/SGPP1/CERS6/UGCG/GALC/CERS5/NEU2/HEXB/CERS3/SGPL1/ENPP7/B4GALT6/ACER2/PLPP1/SMPD4/NEU3/GBA/DEGS2/ACER3/NEU1/PLPP3/SPHK1/SPHK2	23
KEGG	hsa05130	Pathogenic Escherichia coli infection	83/3289	197/8135	0.3362	0.689	0.5928	CASP3/NCK1/ITGB1/MAP3K7/CASP1/SEC24B/TNFSF10/CHUK/ARHGEF12/GNA13/ACTR3/ACTR2/ROCK1/NCKAP1/FAS/TLR4/TAB2/BAIAP2L1/RAB1A/IRAK4/CDC42/MYO6/ROCK2/GNA12/ABI1/MYO5A/IKBKB/WASF1/CLDN2/ARPC3/ARPC4/EZR/TLR5/TUBB/NCL/ARPC1A/CASP9/CLDN6/F2R/ACTR3C/CLDN17/WASF3/NAIP/CASP4/MYO1A/PAK1/WIPF2/FYN/BAIAP2/MAPK9/ARHGEF2/ACTR3B/TNF/PYCARD/TUBB4B/MYD88/MYO5C/CLDN14/ARPC2/TUBB8/CLDN4/CXCL8/CYTH1/CLDN19/SEC24A/TAB1/ACTG1/SLC9A3R1/BAK1/MYO10/ARPC5/CLDN11/NCKAP1L/PTPN11/CYTH2/PTPN6/RIPK1/ABCF2/TAB3/CTTN/ARPC5L/OCLN/TNFRSF10A	83
KEGG	hsa04920	Adipocytokine signaling pathway	30/3289	69/8135	0.3442	0.7009	0.6031	PRKAA1/CHUK/ACSL3/JAK2/PRKCQ/ACSL4/ACSL5/AKT3/AGRP/IKBKB/PRKAB1/NFKBIE/RXRA/CPT1C/POMC/ACSL1/CPT1A/PRKAG1/MAPK9/TNF/SOCS3/G6PC3/AKT2/PRKAG3/ADIPOR1/AKT1/PTPN11/PCK2/TNFRSF1B/NPY	30
KEGG	hsa01522	Endocrine resistance	42/3289	98/8135	0.3467	0.7018	0.6039	CCND1/PIK3CA/RB1/PIK3CB/SOS2/BCL2/PIK3R1/PRKACB/NCOR1/AKT3/PIK3R3/NCOA3/SHC4/GNAS/MDM2/GRB2/JAG2/NRAS/MAP2K1/SOS1/CDKN2C/MAPK9/CDK4/TP53/MED1/ADCY5/AKT2/PIK3CD/BIK/DLL4/DLL3/KRAS/NOTCH4/ADCY2/AKT1/HRAS/CDKN1B/CDKN2A/ADCY3/E2F3/E2F2/GPER1	42
KEGG	hsa05340	Primary immunodeficiency	17/3289	38/8135	0.3502	0.7045	0.6062	DCLRE1C/IL7R/ADA/UNG/TAP2/CD40LG/PTPRC/BLNK/IL2RG/CD40/JAK3/CD8A/ICOS/TNFRSF13B/CD3E/RFXAP/RFX5	17
KEGG	hsa00052	Galactose metabolism	14/3289	31/8135	0.358	0.7097	0.6106	UGP2/PGM2/GALE/GANC/PGM1/MGAM/B4GALT1/GALK1/G6PC3/GALM/LCT/HK1/HK2/B4GALT2	14
KEGG	hsa05310	Asthma	14/3289	31/8135	0.358	0.7097	0.6106	HLA-DMB/HLA-DRA/HLA-DMA/RNASE3/HLA-DOA/HLA-DQA1/HLA-DQA2/CD40LG/FCER1G/TNF/CD40/HLA-DPA1/HLA-DQB1/PRG2	14
KEGG	hsa05221	Acute myeloid leukemia	29/3289	67/8135	0.3596	0.7097	0.6106	FLT3/CCND1/PIK3CA/CHUK/PIK3CB/SOS2/RUNX1/EIF4EBP1/PIK3R1/AKT3/JUP/PIK3R3/IKBKB/GRB2/STAT5B/PIM1/NRAS/MAP2K1/SOS1/TCF7/AKT2/PIK3CD/CSF1R/KRAS/PML/AKT1/HRAS/STAT5A/CCNA1	29
KEGG	hsa04725	Cholinergic synapse	48/3289	113/8135	0.3612	0.7097	0.6106	ITPR2/GNGT2/PIK3CA/JAK2/GNG10/PIK3CB/BCL2/CREB1/PIK3R1/PRKACB/SLC18A3/GNG5/CHAT/AKT3/PIK3R3/PLCB1/CREB3L4/GNAQ/NRAS/MAP2K1/GNB3/FYN/CREB5/PIK3R5/ADCY5/CHRNA3/AKT2/PIK3CD/CAMK2G/ITPR1/CREB3/KRAS/GNB4/GNB1/CHRNB2/CACNA1F/GNA11/GNG11/PLCB2/PLCB4/ADCY2/AKT1/HRAS/CREB3L1/PRKCB/CAMK2D/ADCY3/KCNQ1	48
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	30/3289	70/8135	0.3821	0.7463	0.6421	ATP6V1C1/CASP3/CHUK/ATP6V1H/ADAM10/CDC42/ATP6V1A/IKBKB/ATP6V1G2/ATP6V0D1/ATP6V0A1/PAK1/ATP6V1G1/ATP6V1F/MAPK9/ADAM17/LYN/ATP6V0B/ATP6V1D/ATP6V0A2/CXCL3/CXCL8/CXCR2/CXCR1/ATP6V1C2/PTPN11/JAM3/ATP6V1B2/ATP6AP1/MET	30
KEGG	hsa04072	Phospholipase D signaling pathway	62/3289	148/8135	0.3875	0.7525	0.6474	EGF/LPAR6/PIK3CA/GNA13/PLA2G4A/PIK3CB/SOS2/PLD1/PIK3R1/DGKE/AGPAT2/AKT3/MRAS/GNA12/PIK3R3/SHC4/GNAS/PDGFRA/GRB2/PDGFA/DGKA/PLCB1/RAPGEF3/F2R/NRAS/MAP2K1/RRAS/FCER1G/FYN/SOS1/PLPP1/PIK3R5/AGPAT5/ADCY5/AKT2/PIK3CD/DGKK/LPAR3/DNM1/KRAS/PIP5K1C/CXCL8/CYTH1/CXCR2/PDGFRB/PLCB2/PLCB4/CXCR1/ADCY2/PLPP3/GAB1/SPHK1/AKT1/PTPN11/CYTH2/HRAS/SPHK2/GAB2/DNM2/GRM2/ADCY3/DNM3	62
KEGG	hsa04664	Fc epsilon RI signaling pathway	29/3289	68/8135	0.3986	0.7695	0.6621	PIK3CA/PLA2G4A/PIK3CB/SOS2/ALOX5AP/PIK3R1/RAC2/AKT3/MAP2K6/PIK3R3/GRB2/NRAS/MAP2K1/PDPK1/FCER1G/FYN/SOS1/LCP2/MAPK9/LYN/TNF/AKT2/PIK3CD/KRAS/RAC3/VAV2/AKT1/HRAS/GAB2	29
KEGG	hsa04923	Regulation of lipolysis in adipocytes	24/3289	56/8135	0.4042	0.7717	0.6639	PIK3CA/PIK3CB/PDE3B/PIK3R1/PRKACB/ADRB2/AKT3/PIK3R3/GNAS/TSHR/ADCY5/AKT2/PIK3CD/NPR1/MGLL/ADCY2/PRKG2/AKT1/PLIN1/NPPA/PTGS1/LIPE/NPY/ADCY3	24
KEGG	hsa04371	Apelin signaling pathway	58/3289	139/8135	0.4083	0.7717	0.6639	PIK3R4/TFAM/PRKAA1/CCND1/ITPR2/GNGT2/SMAD4/RPS6/GNA13/GNG10/MYL3/PIK3C3/PDE3B/PRKACB/KLF2/GNG5/SMAD2/AKT3/CALM3/MRAS/PRKAB1/PLCB1/GNAQ/SLC8A2/MAP1LC3B/NRAS/MAP2K1/RRAS/GNB3/PRKAG1/PIK3R5/ADCY5/MEF2A/AKT2/SMAD3/ITPR1/CALM1/PRKAG3/MEF2C/KRAS/GNB4/ACTA2/GNB1/PRKCE/SLC8A3/GNG11/APLN/PLCB2/PLCB4/ADCY2/SPHK1/SLC9A1/AKT1/PLIN1/HRAS/SPHK2/LIPE/ADCY3	58
KEGG	hsa04612	Antigen processing and presentation	33/3289	78/8135	0.4089	0.7717	0.6639	HLA-DMB/NFYB/HSPA4/HLA-DRA/HLA-DMA/CREB1/CD74/LGMN/KIR3DL2/HLA-DOA/KIR2DL4/HSPA6/HLA-DQA1/HLA-DQA2/TAP2/TAPBP/HSPA1L/PSME1/TNF/KIR2DS4/PSME3/HLA-DPA1/KIR3DL1/HLA-DQB1/CD8A/KIR3DL3/KIR2DL1/KIR2DL3/RFXAP/RFX5/CTSL/CANX/HSPA1B	33
KEGG	hsa04721	Synaptic vesicle cycle	33/3289	78/8135	0.4089	0.7717	0.6639	ATP6V1C1/ATP6V1H/STX2/SLC18A3/ATP6V1A/ATP6V1G2/ATP6V0D1/ATP6V0A1/SLC18A1/ATP6V1G1/ATP6V1F/ATP6V0B/AP2S1/DNM1/ATP6V1D/NSF/SLC18A2/ATP6V0A2/ATP6V1C2/SLC6A5/RAB3A/SLC6A11/ATP6V1B2/AP2A2/STX1B/CPLX1/AP2M1/DNM2/SLC6A13/CLTB/CPLX4/DNM3/NAPA	33
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/3289	20/8135	0.4198	0.7878	0.6778	XYLT2/CSGALNACT2/DSE/CHPF/CHST14/CSGALNACT1/CHST15/CHST12/CHST7	9
KEGG	hsa05216	Thyroid cancer	16/3289	37/8135	0.424	0.7909	0.6804	CCND1/NCOA4/TPR/POLK/TFG/RXRA/NRAS/MAP2K1/TCF7/TP53/GADD45B/RET/KRAS/BAK1/PAX8/HRAS	16
KEGG	hsa05224	Breast cancer	61/3289	147/8135	0.4262	0.7909	0.6804	NCOA1/EGF/FGF19/CCND1/PIK3CA/AXIN2/RB1/PIK3CB/SOS2/PTEN/FZD6/APC/PIK3R1/DVL3/POLK/CSNK1A1L/AKT3/PIK3R3/AXIN1/NCOA3/SHC4/GRB2/JAG2/WNT10A/FZD3/FZD7/NRAS/MAP2K1/SOS1/TCF7/CDK4/TP53/GADD45B/AKT2/PIK3CD/GSK3B/FGFR1/CSNK1A1/FGF10/DLL4/CDK6/DLL3/KRAS/WNT7B/FGF2/NOTCH4/HES1/WNT5B/BAK1/APC2/LRP6/AKT1/WNT10B/DVL1/HRAS/BRCA2/WNT3/E2F3/BRCA1/E2F2/DVL2	61
KEGG	hsa05134	Legionellosis	24/3289	57/8135	0.4477	0.8262	0.7108	CASP3/SAR1B/CASP1/TLR2/CLK1/HBS1L/TLR4/RAB1A/C3/CLK4/HSPA6/TLR5/HSPA1L/CASP9/CR1/NAIP/TNF/PYCARD/MYD88/BCL2L13/CXCL3/CXCL8/HSF1/HSPA1B	24
KEGG	hsa00010	Glycolysis / Gluconeogenesis	28/3289	67/8135	0.456	0.8328	0.7166	PGM2/DLD/MINPP1/FBP1/PGM1/TPI1/GAPDHS/ADH1A/ALDH3A1/G6PC3/PGAM2/PGK1/PDHB/ADH6/ACSS1/GALM/BPGM/ALDH7A1/AKR1A1/DLAT/ALDH3B2/PCK2/ADH5/ACSS2/ALDH2/HK1/PDHA1/HK2	28
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	10/3289	23/8135	0.4606	0.8328	0.7166	GLS/AQP1/ATP1A2/SLC4A4/MDH1/ATP1A3/PCK2/GLUD1/ATP1A4/GLS2	10
KEGG	hsa04064	NF-kappa B signaling pathway	43/3289	104/8135	0.4613	0.8328	0.7166	BIRC3/DDX58/MAP3K7/BIRC2/TNFSF13B/ATM/CHUK/PRKCQ/TLR4/TRAF5/BCL2/TAB2/CYLD/LY96/IRAK4/XIAP/CSNK2A2/CSNK2B/CFLAR/IKBKB/CCL4L2/LBP/CCL4/CD40LG/MALT1/LYN/BLNK/GADD45B/TNF/CD40/MYD88/CSNK2A1/PARP1/CXCL3/CXCL8/TAB1/VCAM1/RELB/RIPK1/PRKCB/TAB3/ICAM1/TRIM25	43
KEGG	hsa04620	Toll-like receptor signaling pathway	43/3289	104/8135	0.4613	0.8328	0.7166	MAP3K7/PIK3CA/CHUK/TLR2/TBK1/PIK3CB/TLR4/TLR1/TAB2/PIK3R1/LY96/IRAK4/AKT3/MAP2K6/PIK3R3/IKBKB/IFNAR1/CCL4L2/CD86/LBP/CCL4/TLR5/CCL3L1/TOLLIP/MAP2K1/TLR3/MAPK9/TNF/CTSK/AKT2/PIK3CD/STAT1/CCL3/CD40/MYD88/CXCL9/IFNB1/CXCL8/TAB1/AKT1/RIPK1/IFNA21/TLR6	43
KEGG	hsa04670	Leukocyte transendothelial migration	47/3289	114/8135	0.4663	0.833	0.7167	ITGA4/MYLPF/ITGB1/PIK3CA/ROCK1/MYL5/PIK3CB/PIK3R1/TXK/RAC2/MYL12A/CDC42/ROCK2/PIK3R3/RAP1A/ITGAL/ACTN4/CLDN2/EZR/ITK/CLDN6/RAPGEF3/CLDN17/PIK3CD/CLDN14/CD99/CLDN4/CLDN19/CYBA/ACTG1/VAV2/PXN/CLDN11/VCAM1/PTPN11/JAM3/PRKCB/ESAM/PECAM1/ICAM1/MYL12B/ARHGAP35/MYL9/OCLN/NCF2/MSN/BCAR1	47
KEGG	hsa04260	Cardiac muscle contraction	36/3289	87/8135	0.4688	0.833	0.7167	COX7A2/MYL3/COX6B1/COX4I2/UQCR10/COX8A/COX6B2/SLC8A2/CYC1/UQCRB/MYH7/CACNA2D2/COX5A/CACNG8/UQCR11/UQCRC2/COX6C/SLC9A7/CACNB2/COX5B/UQCRQ/SLC9A6/COX7A2L/CACNA1F/SLC8A3/COX7A1/UQCRC1/COX4I1/ATP1A2/ATP1A3/SLC9A1/UQCRH/UQCRHL/ASPH/COX7B/ATP1A4	36
KEGG	hsa04730	Long-term depression	25/3289	60/8135	0.4713	0.833	0.7167	ITPR2/GUCY1B1/GNA13/PLA2G4A/PPP2R1B/GNA12/GNAS/PLCB1/GNAQ/GNAZ/NRAS/MAP2K1/PPP1R17/LYN/PPP2CA/ITPR1/KRAS/GRIA1/GUCY1A1/GNA11/PLCB2/PLCB4/PRKG2/HRAS/PRKCB	25
KEGG	hsa03410	Base excision repair	14/3289	33/8135	0.4731	0.833	0.7167	TDG/MBD4/HMGB1/PARP4/POLE2/PARP2/UNG/NTHL1/APEX1/PARP3/PARP1/POLD2/MPG/FEN1	14
KEGG	hsa05142	Chagas disease	42/3289	102/8135	0.4764	0.833	0.7167	IFNGR1/PIK3CA/CHUK/GNA15/TLR2/FAS/PIK3CB/TLR4/PIK3R1/TGFB2/IRAK4/PPP2R1B/C3/SMAD2/AKT3/PIK3R3/CFLAR/GNAS/IKBKB/PLCB1/GNAQ/CCL3L1/MAPK9/PPP2CA/TNF/AKT2/PIK3CD/CCL3/KNG1/MYD88/PPP2R2A/C1QA/IFNB1/CCL2/GNA11/CXCL8/TGFB1/PLCB2/PLCB4/AKT1/CD3E/TLR6	42
KEGG	hsa05146	Amoebiasis	42/3289	102/8135	0.4764	0.833	0.7167	CASP3/CD1C/FN1/PIK3CA/ARG1/GNA15/TLR2/PIK3CB/TLR4/RAB5A/PIK3R1/PRKACB/TGFB2/CD1B/SERPINB10/CD1E/PIK3R3/GNAS/ACTN4/PLCB1/CD1D/GNAQ/LAMC1/RAB5C/TNF/HSPB1/PIK3CD/RAB7A/CXCL3/GNA11/CXCL8/CD1A/LAMA3/TGFB1/RAB5B/PLCB2/PLCB4/PRKCB/COL4A2/SERPINB9/COL1A2/IL1R2	42
KEGG	hsa04668	TNF signaling pathway	46/3289	112/8135	0.4807	0.8348	0.7183	DNM1L/BIRC3/CASP3/MAP3K7/BIRC2/PIK3CA/RPS6KA5/CHUK/ITCH/FAS/PIK3CB/TRAF5/CREB1/TAB2/PIK3R1/CXCL5/AKT3/MAP2K6/PIK3R3/CFLAR/IKBKB/BAG4/CREB3L4/IL18R1/MAP2K1/CREB5/MAPK9/TNF/SOCS3/AKT2/PIK3CD/CREB3/IFNB1/CCL2/CXCL3/TAB1/JUNB/VCAM1/AKT1/CREB3L1/RIPK1/TAB3/TNFRSF1B/BCL3/ICAM1/IL15	46
KEGG	hsa04012	ErbB signaling pathway	35/3289	85/8135	0.4853	0.8348	0.7183	EGF/NCK1/PIK3CA/PIK3CB/SOS2/EIF4EBP1/PIK3R1/ABL2/AKT3/PIK3R3/SHC4/GRB2/STAT5B/NRAS/MAP2K1/PAK1/SOS1/CRKL/MAPK9/AKT2/PIK3CD/GSK3B/CAMK2G/KRAS/PAK6/CBLB/GAB1/AKT1/HRAS/STAT5A/BUB1B-PAK6/PRKCB/CAMK2D/CDKN1B/PAK4	35
KEGG	hsa00430	Taurine and hypotaurine metabolism	7/3289	16/8135	0.4871	0.8348	0.7183	FMO5/GGT6/CDO1/ADO/FMO1/CSAD/FMO4	7
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	22/3289	53/8135	0.4884	0.8348	0.7183	RAB11A/ATP2B1/PRKACB/GNAS/PLCB1/GNAQ/SLC8A2/AP2S1/TRPV5/DNM1/SLC8A3/ATP1A2/PLCB2/PLCB4/ATP1A3/AP2A2/AP2M1/PRKCB/DNM2/CLTB/DNM3/ATP1A4	22
KEGG	hsa04621	NOD-like receptor signaling pathway	75/3289	184/8135	0.4916	0.8348	0.7183	GBP3/TRPM7/IFI16/GBP1/DEFA1/DEFA1B/DEFA3/DNM1L/CARD16/BIRC3/PKN2/NEK7/MFN1/MAP3K7/ITPR2/BIRC2/CASP1/GBP5/CHUK/TP53BP1/TBK1/OAS1/TLR4/CAMP/ERBIN/TRAF5/BCL2/TAB2/GABARAP/IRAK4/CARD6/XIAP/TXN2/IKBKB/IFNAR1/CARD8/VDAC1/TXN/PLCB1/MAP1LC3B/OAS2/CARD9/TANK/NAIP/CASP4/SUGT1/MAPK9/CASR/MCU/ATG12/TNF/TRPM2/PYCARD/STAT1/RIPK2/ITPR1/MYD88/CASP5/TRPV2/BRCC3/IFNB1/CCL2/ANTXR2/CXCL3/TYK2/CXCL8/CYBA/TAB1/PLCB2/PLCB4/MFN2/RIPK1/TAB3/IFNA21/GBP2	75
KEGG	hsa00310	Lysine degradation	26/3289	63/8135	0.4938	0.8348	0.7183	SETDB2/ASH1L/SETD2/KMT5B/PLOD2/KMT2E/DLD/NSD3/KMT2C/COLGALT2/NSD1/ACAT1/SETMAR/SUV39H2/AASS/HADHA/KMT5C/HADH/KMT2A/ACAT2/TMLHE/ALDH7A1/AADAT/CAMKMT/ALDH2/DHTKD1	26
KEGG	hsa04145	Phagosome	62/3289	152/8135	0.4949	0.8348	0.7183	ATP6V1C1/HLA-DMB/ITGB1/ATP6V1H/TLR2/DYNC1LI1/EEA1/HLA-DRA/PIK3C3/HLA-DMA/TLR4/FCGR3B/RAB5A/PIKFYVE/C3/STX7/ATP6V1A/SEC61A1/SEC61A2/TFRC/HLA-DOA/HLA-DQA1/HLA-DQA2/TAP2/TUBB/ITGA2/THBS1/ATP6V1G2/THBS4/ATP6V0D1/RAB5C/ATP6V0A1/ATP6V1G1/ATP6V1F/SFTPD/ATP6V0B/TUBB4B/HLA-DPA1/ATP6V1D/FCGR3A/TUBB8/RAB7A/ATP6V0A2/COLEC11/HLA-DQB1/STX18/HGS/CYBA/RAB5B/ACTG1/RILP/ATP6V1C2/SCARB1/MSR1/ITGAV/ATP6V1B2/TLR6/ATP6AP1/CTSL/CANX/OLR1/NCF2	62
KEGG	hsa04710	Circadian rhythm	13/3289	31/8135	0.5002	0.8395	0.7223	PRKAA1/CLOCK/FBXL3/CUL1/CREB1/SKP1/BHLHE41/PRKAB1/PRKAG1/ARNTL/PRKAG3/NR1D1/CRY1	13
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/3289	14/8135	0.5275	0.8761	0.7538	FUT8/B4GALT1/B3GNT7/B3GNT2/CHST2/B4GALT2	6
KEGG	hsa04977	Vitamin digestion and absorption	10/3289	24/8135	0.5283	0.8761	0.7538	BTD/LMBRD1/SLC19A2/SLC23A1/RBP2/SLC52A3/AWAT2/SCARB1/SLC19A3/SLC46A1	10
KEGG	hsa03020	RNA polymerase	14/3289	34/8135	0.5298	0.8761	0.7538	TWISTNB/POLR2B/POLR2C/POLR1E/POLR1C/POLR2J3/POLR2D/POLR2G/POLR3K/POLR1D/POLR3D/CRCP/ZNRD1/POLR3A	14
KEGG	hsa04929	GnRH secretion	26/3289	64/8135	0.535	0.8802	0.7573	ITPR2/PIK3CA/PIK3CB/PIK3R1/TRPC1/AKT3/PIK3R3/PLCB1/GNAQ/NRAS/MAP2K1/CACNA1I/AKT2/PIK3CD/ITPR1/KRAS/CACNA1F/GNA11/PLCB2/PLCB4/CACNA1G/AKT1/HRAS/PRKCB/HCN3/GPER1	26
KEGG	hsa05140	Leishmaniasis	31/3289	77/8135	0.5556	0.9062	0.7797	ITGA4/HLA-DMB/IFNGR1/ITGB1/MAP3K7/JAK2/TLR2/HLA-DRA/HLA-DMA/TLR4/FCGR3B/TAB2/TGFB2/IRAK4/C3/HLA-DOA/HLA-DQA1/HLA-DQA2/CR1/TNF/STAT1/MYD88/HLA-DPA1/FCGR3A/HLA-DQB1/CYBA/TAB1/TGFB1/PTPN6/PRKCB/NCF2	31
KEGG	hsa05332	Graft-versus-host disease	17/3289	42/8135	0.5562	0.9062	0.7797	HLA-DMB/HLA-DRA/FAS/HLA-DMA/GZMB/KIR3DL2/HLA-DOA/HLA-DQA1/CD86/HLA-DQA2/TNF/HLA-DPA1/KIR3DL1/HLA-DQB1/KIR3DL3/KIR2DL1/KIR2DL3	17
KEGG	hsa04728	Dopaminergic synapse	53/3289	132/8135	0.5595	0.9064	0.7798	PPP2R5E/CLOCK/ITPR2/GNGT2/KIF5B/PPP2R5A/GNG10/PPP1CB/PPP1CC/CREB1/PRKACB/PPP2R3C/PPP2R1B/GNG5/AKT3/CALM3/PPP3CC/GNAS/PLCB1/CREB3L4/GNAQ/GNB3/PPP2R3A/SLC18A1/GRIA4/CREB5/LRTOMT/MAPK9/ADCY5/PPP2CA/AKT2/GSK3B/ARNTL/CAMK2G/ITPR1/CALM1/CREB3/PPP2R2A/GRIA1/GNB4/SLC18A2/GNB1/GNG11/PLCB2/DRD5/PLCB4/AKT1/CREB3L1/PRKCB/CAMK2D/COMT/MAOB/GRIN2B	53
KEGG	hsa04310	Wnt signaling pathway	67/3289	167/8135	0.5625	0.9064	0.7798	DAAM1/RYK/MAP3K7/CCND1/SMAD4/SERPINF1/AXIN2/PPP3R1/FZD6/TBL1XR1/CUL1/APC/PRKACB/DVL3/NFATC3/RAC2/CACYBP/CSNK1A1L/RUVBL1/CSNK2A2/ROCK2/SKP1/CSNK2B/AXIN1/PPP3CC/PLCB1/PORCN/NFATC4/WNT10A/FZD3/FZD7/CHD8/CXXC4/CTNND2/EP300/TCF7/MAPK9/TP53/GSK3B/CCND2/RNF43/SMAD3/CAMK2G/CSNK1A1/CTBP1/WNT7B/RAC3/CSNK2A1/PSEN1/WNT5B/PLCB2/PLCB4/SFRP2/APC2/NFATC2/LRP6/TLE2/WNT10B/DVL1/SENP2/PRICKLE3/WNT3/BAMBI/PRKCB/CAMK2D/GPC4/DVL2	67
KEGG	hsa04151	PI3K-Akt signaling pathway	142/3289	354/8135	0.5701	0.9064	0.7798	PPP2R5E/ITGA4/FLT3/EGF/PRKAA1/FGF19/GYS2/PKN2/ITGB1/CCND1/GNGT2/LPAR6/FN1/PIK3CA/RPS6/RBL2/HSP90B1/CCNE2/CHUK/JAK2/PPP2R5A/TLR2/GNG10/PIK3CB/COL9A2/SOS2/PTEN/EIF4EBP1/TLR4/FOXO3/BCL2/CREB1/IL7R/YWHAZ/PIK3R1/PPP2R3C/PPP2R1B/GNG5/EPHA2/COL6A3/ITGA1/AKT3/YWHAB/PIK3R3/COL6A1/PGF/IKBKB/MDM2/IFNAR1/PDGFRA/CSF3/GRB2/ANGPT1/VTN/PDGFA/EPO/RXRA/CREB3L4/ITGA2/EPOR/MYB/CASP9/THBS1/F2R/EIF4E1B/NRAS/MAP2K1/THBS4/PDPK1/CSH1/GNB3/LAMC1/PPP2R3A/SOS1/EIF4E2/CREB5/PIK3R5/TNR/CDK4/ITGA9/TP53/NTF4/PPP2CA/IL2RG/G6PC3/AKT2/PIK3CD/GSK3B/CCND2/FGFR1/LPAR3/OSM/FGF10/CREB3/SGK3/JAK3/CDK6/CSF1R/KRAS/PPP2R2A/PRL/FGF2/GNB4/DDIT4/GNB1/IFNB1/MAGI2/MTCP1/THEM4/TNN/IL6R/LAMA3/VEGFB/KDR/EFNA4/GNG11/PDGFRB/CSH2/MCL1/AKT1/OSMR/BCL2L11/CHAD/PCK2/ITGAV/HRAS/VEGFA/COL6A5/CREB3L1/MAGI1/COL4A2/IFNA21/CCNE1/CDKN1B/COL1A2/EIF4B/ITGB4/COL9A3/IL3RA/BRCA1/MET/NGFR	142
KEGG	hsa01230	Biosynthesis of amino acids	30/3289	75/8135	0.5742	0.9064	0.7798	RPEL1/ARG1/ASNS/PHGDH/PRPS2/ABHD14A-ACY1/BCAT2/MTR/SDSL/GOT1/TPI1/ACO2/IDH1/ACY1/MAT1A/PGAM2/GPT/MAT2B/PGK1/ASL/GOT2/PYCR1/ACO1/SHMT1/IDH3A/ASS1/PRPS1/OTC/IDH3B/RPIA	30
KEGG	hsa04934	Cushing syndrome	62/3289	155/8135	0.5745	0.9064	0.7798	CCND1/ITPR2/AXIN2/CCNE2/RB1/FZD6/CREB1/APC/PRKACB/DVL3/AXIN1/GNAS/RAP1A/PLCB1/CREB3L4/GNAQ/WNT10A/FZD3/FZD7/POMC/MAP2K1/CREB5/CACNA1I/CDKN2C/TCF7/CDK4/ADCY5/USP8/GSK3B/CAMK2G/ITPR1/CREB3/CDK6/WNT7B/CYP11A1/CACNA1F/KMT2A/WNT5B/GNA11/HSD3B2/PLCB2/PLCB4/ADCY2/APC2/CACNA1G/SCARB1/WNT10B/DVL1/CREB3L1/WNT3/CAMK2D/CCNE1/CDKN1B/CDKN2A/ARNT/ADCY3/PDE8A/E2F3/E2F2/DVL2/MEN1/LDLR	62
KEGG	hsa04917	Prolactin signaling pathway	28/3289	70/8135	0.5747	0.9064	0.7798	CCND1/PIK3CA/JAK2/PIK3CB/SOS2/FOXO3/PIK3R1/AKT3/PIK3R3/SHC4/GRB2/STAT5B/SOCS4/NRAS/MAP2K1/SOS1/MAPK9/SOCS3/AKT2/PIK3CD/GSK3B/STAT1/CCND2/KRAS/PRL/AKT1/HRAS/STAT5A	28
KEGG	hsa04927	Cortisol synthesis and secretion	26/3289	65/8135	0.5753	0.9064	0.7798	ITPR2/CREB1/PRKACB/GNAS/PLCB1/CREB3L4/GNAQ/POMC/CREB5/CACNA1I/ADCY5/ITPR1/CREB3/CYP11A1/CACNA1F/GNA11/HSD3B2/PLCB2/PLCB4/ADCY2/CACNA1G/SCARB1/CREB3L1/ADCY3/PDE8A/LDLR	26
KEGG	hsa02010	ABC transporters	18/3289	45/8135	0.5799	0.9093	0.7823	ABCD3/ABCA5/ABCD2/ABCB4/ABCB1/ABCA8/ABCA1/ABCB7/ABCB10/TAP2/ABCC3/ABCA4/CFTR/ABCC2/ABCB5/ABCC9/ABCA10/ABCG4	18
KEGG	hsa01523	Antifolate resistance	12/3289	30/8135	0.588	0.9114	0.7841	CHUK/GGH/IKBKB/ABCC3/TYMS/TNF/ABCC2/FPGS/FOLR3/MTHFR/SHMT1/SLC46A1	12
KEGG	hsa00564	Glycerophospholipid metabolism	39/3289	98/8135	0.5894	0.9114	0.7841	CEPT1/LPIN2/PEMT/LYPLA1/GPCPD1/PLA2G4A/PLA2G2D/LPGAT1/PLD1/GNPAT/DGKE/PLD4/GPAM/CHPT1/CHAT/AGPAT2/DGKA/ADPRM/PLPP1/MBOAT2/PCYT2/AGPAT5/DGKK/GPAT3/LPCAT2/PHOSPHO1/PTDSS1/PLA2G12A/PTDSS2/ETNK1/PLPP3/GPAT4/CHKB/CDS2/PLA2G2E/PLPP5/LPCAT3/PLA2G10/PNPLA6	39
KEGG	hsa05217	Basal cell carcinoma	25/3289	63/8135	0.5957	0.9114	0.7841	AXIN2/FZD6/APC/DVL3/POLK/AXIN1/WNT10A/FZD3/FZD7/PTCH2/TCF7/TP53/GADD45B/KIF7/GSK3B/WNT7B/WNT5B/BAK1/APC2/WNT10B/DVL1/WNT3/SUFU/DVL2/BMP4	25
KEGG	hsa00100	Steroid biosynthesis	8/3289	20/8135	0.5996	0.9114	0.7841	LBR/SC5D/LSS/TM7SF2/SOAT1/NSDHL/EBP/FDFT1	8
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	42/3289	106/8135	0.6042	0.9114	0.7841	ITPR2/GNA13/NACA/BCL2/PLD1/CREB1/PRKACB/GNA12/GNAS/PDE4C/PLCB1/RXRA/CREB3L4/GNAQ/MAP2K1/GCM1/CREB5/CASR/AKAP13/ADCY5/MEF2A/FGFR1/ITPR1/TRPV5/JUND/MEF2C/CREB3/MMP24/MMP25/NR4A2/GNA11/SLC9A3R1/PLCB2/PLCB4/ADCY2/LRP6/RUNX2/CREB3L1/PRKCB/PTHLH/ADCY3/MAFB	42
KEGG	hsa04916	Melanogenesis	40/3289	101/8135	0.6049	0.9114	0.7841	FZD6/MITF/CREB1/PRKACB/DVL3/CALM3/GNAS/PLCB1/CREB3L4/GNAQ/WNT10A/FZD3/FZD7/POMC/NRAS/MAP2K1/EP300/TCF7/ADCY5/GSK3B/CAMK2G/CALM1/CREB3/KRAS/WNT7B/WNT5B/PLCB2/PLCB4/ADCY2/WNT10B/DVL1/HRAS/CREB3L1/WNT3/PRKCB/CAMK2D/EDNRB/TYRP1/ADCY3/DVL2	40
KEGG	hsa00730	Thiamine metabolism	6/3289	15/8135	0.6102	0.9114	0.7841	AK1/NTPCR/TPK1/AK8/ALPL/AK4	6
KEGG	hsa04971	Gastric acid secretion	30/3289	76/8135	0.6107	0.9114	0.7841	ITPR2/PRKACB/CALM3/KCNJ1/GNAS/PLCB1/EZR/GNAQ/KCNJ16/ADCY5/KCNJ10/CAMK2G/ITPR1/CALM1/ATP4A/ATP1A2/ACTG1/CFTR/PLCB2/PLCB4/ADCY2/ATP1A3/SLC9A1/GAST/SLC9A4/PRKCB/CAMK2D/ADCY3/KCNQ1/ATP1A4	30
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	77/3289	194/8135	0.6111	0.9114	0.7841	IFNGR1/CASP3/CCND1/ITPR2/GNGT2/EIF2AK2/PIK3CA/CHUK/JAK2/RB1/GNG10/TBK1/FAS/PPP3R1/PIK3CB/PIK3C3/HIF1A/MAPKAPK2/CREB1/PIK3R1/ATG3/NFATC3/C3/GNG5/CLEC2B/AKT3/CALM3/MAP2K6/PIK3R3/PPP3CC/CD200R1/IKBKB/IFNAR1/CD86/NFATC4/IL6ST/MAP1LC3B/CASP9/NRAS/MAP2K1/GNB3/EP300/TLR3/TCF7/MAPK9/PIK3R5/CDK4/TP53/LYN/AKT2/PIK3CD/GSK3B/STAT1/ITPR1/CALM1/CDK6/KRAS/FGF2/GNB4/GNB1/IFNB1/CXCL3/TYK2/CXCL8/MICB/GNG11/BAK1/NFATC2/AKT1/HRAS/VEGFA/IFNA21/RPS27A/E2F3/ICAM1/E2F2/CD200R1L	77
KEGG	hsa04520	Adherens junction	28/3289	71/8135	0.6124	0.9114	0.7841	IQGAP1/MAP3K7/SSX2IP/SMAD4/LMO7/RAC2/CDC42/CSNK2A2/NECTIN2/CSNK2B/WAS/YES1/WASF1/ACTN4/WASF3/EP300/FYN/BAIAP2/TCF7/SMAD3/FGFR1/RAC3/CSNK2A1/ACTG1/PTPRM/PTPN6/SORBS1/MET	28
KEGG	hsa04926	Relaxin signaling pathway	51/3289	129/8135	0.6156	0.9114	0.7841	GNGT2/PIK3CA/GNA15/GNG10/PIK3CB/SOS2/CREB1/PIK3R1/PRKACB/RXFP3/GNG5/SMAD2/AKT3/PIK3R3/SHC4/GNAS/GRB2/PLCB1/CREB3L4/NRAS/MAP2K1/GNB3/SOS1/CREB5/MAPK9/PRKCZ/ADCY5/AKT2/PIK3CD/CREB3/KRAS/GNB4/ACTA2/GNB1/VEGFB/GNG11/TGFB1/PLCB2/PLCB4/ADCY2/AKT1/HRAS/VEGFA/CREB3L1/RLN3/COL4A2/RLN1/RXFP2/COL1A2/EDNRB/ADCY3	51
KEGG	hsa00561	Glycerolipid metabolism	24/3289	61/8135	0.6166	0.9114	0.7841	LPIN2/LIPF/DGKE/GPAM/AGPAT2/DGKA/TKFC/PLPP1/MBOAT2/AGPAT5/DGKK/GPAT3/DGAT1/MGLL/MOGAT2/ALDH7A1/AKR1A1/PLPP3/GPAT4/GK/PLPP5/LPL/ALDH2/DGAT2	24
KEGG	hsa00650	Butanoate metabolism	11/3289	28/8135	0.6196	0.9114	0.7841	OXCT1/HMGCS1/L2HGDH/ACAT1/ACSM3/ABAT/HADHA/HADH/ACAT2/ACSM2B/HMGCL	11
KEGG	hsa00330	Arginine and proline metabolism	20/3289	51/8135	0.6224	0.9114	0.7841	ARG1/L3HYPDH/AMD1/GOT1/CKMT1B/OAT/LAP3/P4HA3/GOT2/SAT1/PYCR1/CARNS1/ALDH7A1/AZIN2/SRM/MAOB/ALDH2/ODC1/ALDH4A1/P4HA2	20
KEGG	hsa04936	Alcoholic liver disease	56/3289	142/8135	0.6273	0.9114	0.7841	LPIN2/PRKAA1/TRA2B/CASP3/MAP3K7/CCND1/ACADM/TRA2A/CHUK/TBK1/FAS/TLR4/FOXO3/TAB2/SIRT1/LY96/IRAK4/ACOX3/C3/AKT3/MAP2K6/IKBKB/CYP2E1/PRKAB1/LBP/CPT1C/ADH1A/SREBF1/CPT1A/PRKAG1/C3AR1/TCF7/MAPK9/FOXO1/TNF/AKT2/GSK3B/MYD88/PRKAG3/ADIPOR1/C1QA/SCD/IFNB1/ADH6/CXCL3/CXCL8/TAB1/ALDH7A1/C2/AKT1/ADH5/RIPK1/TAB3/IFNA21/C4B/ALDH2	56
KEGG	hsa00920	Sulfur metabolism	4/3289	10/8135	0.6285	0.9114	0.7841	TST/ETHE1/PAPSS1/BPNT1	4
KEGG	hsa04142	Lysosome	52/3289	132/8135	0.6289	0.9114	0.7841	ASAH1/MFSD8/CTSO/AP4E1/ATP6V1H/AP4S1/AP1G1/CLN5/GALC/LGMN/LITAF/NPC2/AP1S2/HEXB/MAN2B1/AP3S1/NAGA/ARSB/AP4B1/LAPTM5/CTNS/CTSH/ATP6V0D1/AP3M2/ATP6V0A1/AP4M1/CTSC/AP1M1/GALNS/ATP6V0B/CTSK/SLC11A2/CLN3/CTSD/ATP6V0A2/CD164/GBA/SGSH/SLC17A5/AP3S2/ACP5/MANBA/NEU1/NAGLU/CD68/CTSZ/FUCA1/CLTB/GM2A/ATP6AP1/CTSL/ENTPD4	52
KEGG	hsa05031	Amphetamine addiction	27/3289	69/8135	0.6319	0.9114	0.7841	HDAC2/PPP1CB/PPP3R1/PPP1CC/CREB1/PRKACB/SIRT1/CALM3/PPP3CC/GNAS/CREB3L4/SLC18A1/GRIA4/CREB5/ADCY5/CAMK2G/CALM1/CREB3/FOSB/GRIA1/SLC18A2/CREB3L1/GRIN3B/PRKCB/CAMK2D/MAOB/GRIN2B	27
KEGG	hsa05152	Tuberculosis	71/3289	180/8135	0.635	0.9114	0.7841	HLA-DMB/IFNGR1/CASP3/NFYB/ARHGEF12/ATP6V1H/JAK2/TLR2/HSPA9/EEA1/HLA-DRA/PPP3R1/PIK3C3/HLA-DMA/TLR4/CAMP/TLR1/FCGR3B/BCL2/CREB1/RAB5A/TGFB2/IRAK4/C3/CD74/AKT3/CALM3/HLA-DOA/PPP3CC/HLA-DQA1/LBP/HLA-DQA2/CASP9/CARD9/CR1/ATP6V0D1/FCER1G/MALT1/RAB5C/ATP6V0A1/EP300/IRAK2/MAPK9/ATP6V0B/TNF/AKT2/STAT1/RIPK2/CAMK2G/CALM1/MYD88/HLA-DPA1/CTSD/FCGR3A/RAB7A/ATP6V0A2/IFNB1/HLA-DQB1/IL10RA/CLEC4E/TGFB1/RAB5B/SPHK1/AKT1/SPHK2/CAMK2D/IFNA21/RFXAP/TLR6/RFX5/ATP6AP1	71
KEGG	hsa04972	Pancreatic secretion	40/3289	102/8135	0.6358	0.9114	0.7841	ITPR2/AMY1A/AMY1B/AMY1C/RAB11A/PLA2G2D/ATP2B1/AMY2A/SLC12A2/TRPC1/PRSS3/GNAS/RAP1A/SCT/PRSS1/PLCB1/GNAQ/RAB27B/ADCY5/RAB8A/ITPR1/CELA3A/PLA2G12A/CELA2B/ATP1A2/CTRL/CFTR/PLCB2/PLCB4/SLC4A4/ADCY2/ATP1A3/SLC9A1/PLA2G2E/PRKCB/CD38/ADCY3/KCNQ1/PLA2G10/ATP1A4	40
KEGG	hsa00565	Ether lipid metabolism	19/3289	49/8135	0.6459	0.9219	0.7932	CEPT1/PLA2G4A/PLA2G2D/PLD1/PLD4/CHPT1/AGPS/ENPP2/GDPD3/PLPP1/TMEM189/TMEM189-UBE2V1/GDPD1/LPCAT2/PLA2G12A/TMEM86B/PLPP3/PLA2G2E/PLA2G10	19
KEGG	hsa04720	Long-term potentiation	26/3289	67/8135	0.6517	0.9262	0.7969	RPS6KA3/ITPR2/PPP1CB/PPP3R1/PPP1CC/PRKACB/CALM3/PPP3CC/RAP1A/PLCB1/GNAQ/RAPGEF3/NRAS/MAP2K1/EP300/CAMK2G/ITPR1/CALM1/KRAS/GRIA1/PLCB2/PLCB4/HRAS/PRKCB/CAMK2D/GRIN2B	26
KEGG	hsa00770	Pantothenate and CoA biosynthesis	8/3289	21/8135	0.6655	0.9419	0.8104	VNN2/VNN1/PPCDC/PANK3/AASDHPPT/BCAT2/CSAD/ALDH2	8
KEGG	hsa05321	Inflammatory bowel disease	25/3289	65/8135	0.6717	0.9444	0.8126	HLA-DMB/IFNGR1/TLR2/HLA-DRA/HLA-DMA/TLR4/TGFB2/SMAD2/HLA-DOA/HLA-DQA1/HLA-DQA2/IL18R1/TLR5/IL12RB1/TBX21/IL2RG/TNF/STAT1/SMAD3/HLA-DPA1/HLA-DQB1/STAT4/TGFB1/IL22/IL21	25
KEGG	hsa04540	Gap junction	34/3289	88/8135	0.673	0.9444	0.8126	EGF/ITPR2/GUCY1B1/MAP3K2/CDK1/SOS2/PRKACB/GNAS/PDGFRA/GRB2/PDGFA/PLCB1/GNAQ/TUBB/MAPK7/NRAS/MAP2K1/SOS1/ADCY5/ITPR1/TUBB4B/TUBB8/KRAS/GUCY1A1/GNA11/PDGFRB/PLCB2/PLCB4/ADCY2/PRKG2/HRAS/HTR2C/PRKCB/ADCY3	34
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	14/3289	37/8135	0.6847	0.9531	0.8201	PIK3CA/PIK3CB/PIK3R1/KCNJ1/PIK3R3/PDPK1/NR3C2/PIK3CD/KRAS/ATP1A2/ATP1A3/PRKCB/SCNN1G/ATP1A4	14
KEGG	hsa04015	Rap1 signaling pathway	82/3289	210/8135	0.6849	0.9531	0.8201	EGF/FGF19/PRKCI/ITGB1/PIK3CA/PRKD3/SIPA1L1/KRIT1/FYB1/PIK3CB/PIK3R1/RAC2/SKAP1/P2RY1/CDC42/EPHA2/AKT3/CALM3/MRAS/MAP2K6/PIK3R3/RASGRP3/GNAS/RAP1A/PGF/PDGFRA/ITGAL/ANGPT1/PDGFA/PLCB1/ARAP3/GNAQ/THBS1/RAPGEF3/F2R/NRAS/MAP2K1/RRAS/RAPGEF2/PARD6B/LCP2/CRKL/PRKCZ/ADCY5/AKT2/PIK3CD/PARD6A/TIAM1/FGFR1/LPAR3/CALM1/FGF10/CSF1R/KRAS/FGF2/RAC3/MAGI2/TLN1/VEGFB/KDR/EFNA4/PDGFRB/ACTG1/PLCB2/VAV2/PLCB4/ADCY2/TLN2/AKT1/SIPA1L3/HRAS/VEGFA/MAGI1/PRKCB/RAPGEF6/ADCY3/APBB1IP/DOCK4/GRIN2B/MET/BCAR1/NGFR	82
KEGG	hsa04975	Fat digestion and absorption	16/3289	43/8135	0.719	0.9965	0.8574	PLA2G2D/LIPF/AGPAT2/ACAT1/ABCA1/PLPP1/GOT2/DGAT1/ACAT2/PLA2G12A/MOGAT2/PLPP3/SCARB1/PLA2G2E/DGAT2/PLA2G10	16
KEGG	hsa00340	Histidine metabolism	8/3289	22/8135	0.7244	0.9998	0.8602	ALDH3A1/HNMT/UROC1/CARNS1/ALDH7A1/ALDH3B2/MAOB/ALDH2	8
KEGG	hsa05330	Allograft rejection	14/3289	38/8135	0.729	1	0.8604	HLA-DMB/HLA-DRA/FAS/HLA-DMA/GZMB/HLA-DOA/HLA-DQA1/CD86/HLA-DQA2/CD40LG/TNF/CD40/HLA-DPA1/HLA-DQB1	14
KEGG	hsa04659	Th17 cell differentiation	41/3289	108/8135	0.7326	1	0.8604	HLA-DMB/IFNGR1/SMAD4/CHUK/JAK2/HLA-DRA/PPP3R1/HLA-DMA/RUNX1/PRKCQ/HIF1A/NFATC3/SMAD2/HLA-DOA/PPP3CC/IKBKB/HLA-DQA1/NFKBIE/HLA-DQA2/RXRA/IL6ST/STAT5B/IL12RB1/TBX21/MAPK9/IL2RG/STAT1/SMAD3/HLA-DPA1/JAK3/IRF4/HLA-DQB1/IL6R/TYK2/TGFB1/IL22/NFATC2/CD3E/STAT5A/EBI3/IL21	41
KEGG	hsa04974	Protein digestion and absorption	39/3289	103/8135	0.736	1	0.8604	SLC38A2/DPP4/PRCP/SLC3A1/COL9A2/PGA3/PGA4/SLC36A4/COL21A1/PGA5/COL6A3/PRSS3/COL6A1/PRSS1/SLC8A2/COL8A2/COL10A1/SLC3A2/CELA3A/COL28A1/COL5A1/SLC8A3/CELA2B/ATP1A2/CTRL/ATP1A3/COL6A5/COL13A1/COL4A2/COL17A1/KCNE3/COL1A2/COL26A1/COL9A3/COL11A2/SLC36A1/KCNQ1/ATP1A4/COL5A3	39
KEGG	hsa04970	Salivary secretion	35/3289	93/8135	0.7437	1	0.8604	ITPR2/GUCY1B1/AMY1A/AMY1B/AMY1C/ATP2B1/CAMP/PRKACB/AMY2A/ADRB2/SLC12A2/CALM3/GNAS/PLCB1/GNAQ/PRH1/CST3/AQP5/PRH2/ADCY5/ITPR1/CALM1/GUCY1A1/ATP1A2/PLCB2/PLCB4/ADCY2/ATP1A3/SLC9A1/PRKG2/TRPV6/PRKCB/CD38/ADCY3/ATP1A4	35
KEGG	hsa04672	Intestinal immune network for IgA production	18/3289	49/8135	0.7482	1	0.8604	ITGA4/HLA-DMB/TNFSF13B/HLA-DRA/HLA-DMA/HLA-DOA/HLA-DQA1/CD86/HLA-DQA2/CD40LG/CD40/HLA-DPA1/IL15RA/HLA-DQB1/ICOS/TNFRSF13B/TGFB1/IL15	18
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	13/3289	36/8135	0.7558	1	0.8604	NMRK1/SIRT1/NMNAT1/NNT/NT5C1B/QPRT/NADK2/NT5C1A/NMNAT3/NT5C2/NAPRT/CD38/NMRK2	13
KEGG	hsa00410	beta-Alanine metabolism	11/3289	31/8135	0.7701	1	0.8604	HIBCH/ACOX3/ALDH6A1/ALDH3A1/ABAT/HADHA/CARNS1/ALDH7A1/ALDH3B2/CSAD/ALDH2	11
KEGG	hsa04915	Estrogen signaling pathway	52/3289	138/8135	0.773	1	0.8604	NCOA1/ITPR2/PIK3CA/HSP90B1/PIK3CB/SOS2/BCL2/CREB1/PIK3R1/OPRM1/PRKACB/AKT3/CALM3/EBAG9/PIK3R3/NCOA3/SHC4/GNAS/HSPA6/GRB2/PLCB1/CREB3L4/GNAQ/HSPA1L/KRT35/POMC/NRAS/MAP2K1/SOS1/FKBP4/CREB5/NCOA2/ADCY5/AKT2/PIK3CD/KRT19/ITPR1/CALM1/CTSD/CREB3/KRAS/PLCB2/PLCB4/KRT10/ADCY2/AKT1/HRAS/CREB3L1/ADCY3/KRT17/HSPA1B/GPER1	52
KEGG	hsa00515	Mannose type O-glycan biosynthesis	8/3289	23/8135	0.7759	1	0.8604	POMT2/FUT4/B4GALT1/B4GAT1/CHST10/FUT9/POMGNT2/B4GALT2	8
KEGG	hsa04658	Th1 and Th2 cell differentiation	34/3289	92/8135	0.7843	1	0.8604	HLA-DMB/IFNGR1/CHUK/JAK2/HLA-DRA/PPP3R1/MAML2/HLA-DMA/PRKCQ/NFATC3/HLA-DOA/PPP3CC/IKBKB/HLA-DQA1/NFKBIE/JAG2/HLA-DQA2/STAT5B/IL12RB1/TBX21/MAPK9/IL2RG/STAT1/HLA-DPA1/DLL4/JAK3/DLL3/RUNX3/HLA-DQB1/TYK2/STAT4/NFATC2/CD3E/STAT5A	34
KEGG	hsa04921	Oxytocin signaling pathway	58/3289	154/8135	0.7845	1	0.8604	PRKAA1/CCND1/ITPR2/GUCY1B1/RGS2/PLA2G4A/PPP1CB/ROCK1/PPP3R1/PPP1CC/PRKACB/NFATC3/CAMK1D/ROCK2/CALM3/PPP3CC/GNAS/NPR2/PRKAB1/PLCB1/GNAQ/NFATC4/MAPK7/NRAS/MAP2K1/OXT/CACNA2D2/PRKAG1/PIK3R5/ADCY5/TRPM2/CACNG8/NPR1/CAMK2G/ITPR1/CALM1/CACNB2/PPP1R12C/PRKAG3/MEF2C/KRAS/GUCY1A1/CACNA1F/PPP1R12A/ACTG1/PLCB2/PLCB4/ADCY2/MYL6B/NFATC2/NPPA/HRAS/PRKCB/CAMK2D/CD38/ADCY3/MYL9/OXTR	58
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/3289	15/8135	0.7928	1	0.8604	ST6GALNAC4/ST3GAL5/HEXB/ST6GALNAC6/SLC33A1	5
KEGG	hsa05202	Transcriptional misregulation in cancer	73/3289	193/8135	0.7937	1	0.8604	FLT3/DEFA1/DEFA1B/DEFA3/BIRC3/BMI1/COMMD3-BMI1/MLLT3/HDAC2/BIRC2/ATF1/ATM/DDX5/ELANE/ZEB1/RUNX1/FUT8/MITF/KDM6A/LDB1/POLK/NCOR1/GZMB/BMP2K/JUP/AFF1/MDM2/MAX/CD86/CCNT2/PDGFA/RXRA/PRCC/SS18/ETV1/CDKN2C/REL/TP53/GADD45B/FOXO1/PBX3/CCND2/CD40/MLLT1/MEF2C/CSF1R/TCF3/TMPRSS2/CDK14/LMO2/NFKBIZ/KMT2A/HHEX/CXCL8/BAK1/PAX8/HOXA11/RUNX2/PML/PAX7/EWSR1/IGFBP3/LYL1/CDKN1B/ELK4/CCNA1/ETV7/IL1R2/HPGD/MET/MEN1/ARNT2/NGFR	73
KEGG	hsa04924	Renin secretion	25/3289	69/8135	0.7979	1	0.8604	ITPR2/GUCY1B1/PPP3R1/PDE3B/CREB1/PRKACB/ADRB2/CALM3/PPP3CC/GNAS/PLCB1/GNAQ/EDN2/PDE3A/ADCY5/NPR1/ITPR1/CALM1/AQP1/GUCY1A1/CACNA1F/PLCB2/PLCB4/PRKG2/NPPA	25
KEGG	hsa04392	Hippo signaling pathway - multiple species	10/3289	29/8135	0.7993	1	0.8604	SAV1/LATS1/MOB1A/RASSF4/PAK1/RASSF1/NF2/WWTR1/LATS2/TEAD4	10
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	36/3289	98/8135	0.8028	1	0.8604	ITPR2/PIK3CA/P2RY2/PLA2G4A/PPP1CB/PIK3CB/PPP1CC/PRKCQ/PIK3R1/PRKACB/CALM3/MAP2K6/PIK3R3/GNAS/PLCB1/GNAQ/ASIC3/MAPK9/ADCY5/PIK3CD/KNG1/CAMK2G/ITPR1/CALM1/TRPV2/ASIC4/PRKCE/PLCB2/PLCB4/ADCY2/HRH1/ASIC2/HTR2C/PRKCB/CAMK2D/ADCY3	36
KEGG	hsa04014	Ras signaling pathway	88/3289	232/8135	0.8034	1	0.8604	FLT3/EGF/FGF19/SHOC2/GNGT2/PIK3CA/CHUK/GNG10/PLA2G4A/PLA2G2D/TBK1/PIK3CB/SOS2/NF1/PLD1/RAB5A/PIK3R1/PRKACB/RAC2/STK4/ABL2/GNG5/CDC42/EPHA2/AKT3/CALM3/MRAS/PIK3R3/SHC4/RASGRP3/RAP1A/PGF/IKBKB/RALBP1/PDGFRA/GRB2/ANGPT1/PDGFA/RASGRP1/NRAS/MAP2K1/RRAS/GNB3/RAB5C/PAK1/SOS1/MAPK9/REL/NTF4/AKT2/PIK3CD/TIAM1/RASSF1/FGFR1/CALM1/FGF10/CSF1R/KRAS/FGF2/ETS1/GNB4/RAC3/GNB1/RASAL1/PLA2G12A/VEGFB/KDR/EFNA4/GNG11/PDGFRB/RAB5B/PAK6/GAB1/RASGRF2/AKT1/PTPN11/PLA2G2E/HRAS/GAB2/VEGFA/BUB1B-PAK6/PRKCB/RASA4B/GRIN2B/MET/PLA2G10/PAK4/NGFR	88
KEGG	hsa04912	GnRH signaling pathway	34/3289	93/8135	0.8077	1	0.8604	ITPR2/MAP3K2/PLA2G4A/SOS2/PLD1/PRKACB/MAP3K4/CDC42/CALM3/MAP2K6/GNAS/GRB2/PLCB1/GNAQ/MAPK7/MAP3K1/NRAS/MAP2K1/SOS1/MAPK9/ADCY5/CAMK2G/ITPR1/CALM1/KRAS/CACNA1F/GNA11/PLCB2/PLCB4/ADCY2/HRAS/PRKCB/CAMK2D/ADCY3	34
KEGG	hsa04512	ECM-receptor interaction	32/3289	88/8135	0.813	1	0.8604	ITGA4/ITGB1/FN1/CD47/COL9A2/CD44/COL6A3/ITGA1/COL6A1/VTN/ITGA2/THBS1/THBS4/SV2A/LAMC1/TNR/ITGA9/GP6/FRAS1/DMP1/DAG1/TNN/LAMA3/GP5/CHAD/ITGAV/COL6A5/COL4A2/COL1A2/ITGB4/COL9A3/HMMR	32
KEGG	hsa04913	Ovarian steroidogenesis	18/3289	51/8135	0.8135	1	0.8604	CYP1B1/PLA2G4A/ACOT4/PRKACB/GNAS/AKR1C3/BMP6/ADCY5/ACOT2/CYP11A1/HSD3B2/ACOT1/ADCY2/CYP1A1/SCARB1/CYP19A1/ADCY3/LDLR	18
KEGG	hsa04066	HIF-1 signaling pathway	40/3289	109/8135	0.815	1	0.8604	EGF/IFNGR1/PIK3CA/RPS6/CUL2/PIK3CB/EIF4EBP1/TLR4/HIF1A/BCL2/PIK3R1/AKT3/TFRC/PIK3R3/ANGPT1/EPO/ELOC/EIF4E1B/ELOB/MAP2K1/EP300/MKNK2/EIF4E2/AKT2/PIK3CD/CAMK2G/PGK1/PDHB/HMOX1/IL6R/AKT1/NPPA/VEGFA/PRKCB/CAMK2D/CDKN1B/ARNT/HK1/PDHA1/HK2	40
KEGG	hsa03320	PPAR signaling pathway	27/3289	75/8135	0.8165	1	0.8604	SCP2/ACADM/ACSL3/SLC27A2/NR1H3/ACSL4/HMGCS1/ACOX3/ACSL5/RXRA/CPT1C/ACSL1/PDPK1/ME1/ILK/CPT1A/APOA5/SCD/PLIN2/GK/PLIN1/PCK2/FABP5/SORBS1/LPL/OLR1/FADS2	27
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/3289	24/8135	0.8199	1	0.8604	XYLT2/HS3ST3B1/GLCE/EXT2/HS3ST1/HS3ST3A1/HS6ST1/EXTL3	8
KEGG	hsa04930	Type II diabetes mellitus	16/3289	46/8135	0.8243	1	0.8604	PIK3CA/PIK3CB/PIK3R1/PIK3R3/PDX1/IKBKB/SOCS4/MAPK9/PRKCZ/TNF/SOCS3/PIK3CD/PRKCE/CACNA1G/HK1/HK2	16
KEGG	hsa04514	Cell adhesion molecules	55/3289	149/8135	0.8332	1	0.8604	ITGA4/HLA-DMB/ITGB1/SELPLG/CD226/VCAN/PDCD1/HLA-DRA/HLA-DMA/SPN/MPZL1/CD58/ALCAM/NECTIN2/HLA-DOA/HLA-DQA1/CD86/ITGAL/CLDN2/HLA-DQA2/CD40LG/CLDN6/CLDN17/PTPRC/CADM3/ICAM2/ITGA9/SELP/NEGR1/CD40/HLA-DPA1/CLDN14/CD99/NLGN4X/HLA-DQB1/CD8A/SELL/CLDN4/CTLA4/ICOS/CLDN19/CDH2/NEO1/CLDN11/SIGLEC1/VCAM1/PTPRM/JAM3/ITGAV/CD274/ESAM/PECAM1/ICAM1/PVR/OCLN	55
KEGG	hsa04390	Hippo signaling pathway	58/3289	157/8135	0.8367	1	0.8604	BIRC3/PRKCI/CCND1/BIRC2/SMAD4/AXIN2/DLG1/SAV1/PPP1CB/LATS1/BMPR2/PPP1CC/FZD6/APC/YWHAZ/TGFB2/MOB1A/DVL3/GDF7/PPP2R1B/SMAD2/YWHAB/AXIN1/BMP8B/BMP6/WNT10A/FZD3/FZD7/PARD6B/BMP8A/TCF7/PRKCZ/TP53BP2/SMAD7/PPP2CA/GSK3B/CCND2/PARD6A/SMAD3/RASSF1/PPP2R2A/WNT7B/TP73/NF2/WNT5B/TGFB1/ACTG1/WWTR1/LATS2/APC2/WNT10B/DVL1/CRB2/WNT3/DVL2/BMP4/TEAD4/BIRC5	58
KEGG	hsa04978	Mineral absorption	21/3289	60/8135	0.8394	1	0.8604	TRPM7/ATP2B1/MT2A/SLC40A1/MT1E/MT1H/MT1M/HEPHL1/SLC39A4/SLC8A2/SLC11A2/SLC31A1/HMOX1/SLC8A3/MT1F/ATP1A2/ATP1A3/TRPV6/SLC46A1/HEPH/ATP1A4	21
KEGG	hsa04270	Vascular smooth muscle contraction	49/3289	134/8135	0.8432	1	0.8604	CALD1/ITPR2/GUCY1B1/ARHGEF12/GNA13/KCNMB3/PLA2G4A/PPP1CB/PLA2G2D/ROCK1/PPP1CC/PRKCQ/PRKACB/ROCK2/CALM3/GNA12/GNAS/NPR2/KCNMB4/PLCB1/GNAQ/MAP2K1/EDN2/ADCY5/NPR1/ITPR1/CALM1/RAMP1/PPP1R12C/GUCY1A1/ACTA2/ACTG2/PRKCE/CACNA1F/PPP1R12A/GNA11/PLA2G12A/PLCB2/PTGIR/PLCB4/ADCY2/MYL6B/NPPA/PLA2G2E/ADM/PRKCB/ADCY3/PLA2G10/MYL9	49
KEGG	hsa00051	Fructose and mannose metabolism	11/3289	33/8135	0.8439	1	0.8604	GMDS/FPGT/PFKFB2/FBP1/TPI1/TKFC/GMPPB/PMM2/TIGAR/HK1/HK2	11
KEGG	hsa00531	Glycosaminoglycan degradation	6/3289	19/8135	0.8466	1	0.8604	HEXB/ARSB/GALNS/HPSE2/SGSH/NAGLU	6
KEGG	hsa00480	Glutathione metabolism	20/3289	58/8135	0.8558	1	0.8604	GSTA1/RRM2B/GGT6/IDH1/GPX3/GSTK1/GPX1/NAT8/GSTA5/LAP3/GPX7/GPX6/GPX2/SRM/GSS/PRDX6/GSTA3/ODC1/GSTP1/RRM1	20
KEGG	hsa04010	MAPK signaling pathway	110/3289	294/8135	0.8718	1	0.8604	FLT3/EGF/RPS6KA3/FGF19/TAOK3/CASP3/MAP3K7/TAOK1/MAP3K2/RPS6KA5/CHUK/PLA2G4A/FAS/PPP3R1/SOS2/MAPKAPK2/NF1/TAB2/PRKACB/TGFB2/MAP3K4/MAP4K4/DUSP8/NFATC3/IRAK4/RAC2/STK4/CDC42/MAP4K3/EPHA2/AKT3/FLNC/MRAS/GNA12/MAP2K6/PPM1B/MAPKAPK3/MAPK8IP3/RASGRP3/PPP3CC/HSPA6/RAP1A/PGF/IKBKB/PDGFRA/MAX/GRB2/ANGPT1/PDGFA/RASGRP1/MAP4K2/MAPK7/HSPA1L/MAP3K1/NRAS/ECSIT/MAP2K1/RRAS/RAPGEF2/PAK1/MAPKAPK5/SRF/MKNK2/SOS1/CACNA2D2/CACNA1I/PPM1A/CRKL/DUSP3/MAPK9/TP53/NTF4/GADD45B/TNF/HSPB1/AKT2/CACNG8/DUSP7/FLNB/FGFR1/CACNB2/JUND/MYD88/FGF10/MEF2C/CSF1R/KRAS/FGF2/RAC3/CACNA1F/DUSP9/VEGFB/KDR/TAB1/EFNA4/PDGFRB/TGFB1/DAXX/CACNA1G/RELB/RASGRF2/AKT1/HRAS/VEGFA/PRKCB/ELK4/MET/DUSP16/HSPA1B/NGFR	110
KEGG	hsa00450	Selenocompound metabolism	5/3289	17/8135	0.8815	1	0.8604	SEPSECS/PSTK/MTR/KYAT3/PAPSS1	5
KEGG	hsa00260	Glycine, serine and threonine metabolism	13/3289	40/8135	0.8833	1	0.8604	DLD/PHGDH/SDSL/GLDC/GRHPR/AMT/ALAS2/PGAM2/BPGM/ALDH7A1/SHMT1/GCSH/MAOB	13
KEGG	hsa00790	Folate biosynthesis	8/3289	26/8135	0.8875	1	0.8604	PCBD1/GGH/AKR1C3/CBR1/PTS/SPR/FPGS/ALPL	8
KEGG	hsa00860	Porphyrin metabolism	14/3289	43/8135	0.8881	1	0.8604	CP/HEPHL1/HMBS/FXN/UROS/ALAD/ALAS2/HCCS/HMOX1/COX15/HEPH/UGT1A3/UGT2B28/UGT2B11	14
KEGG	hsa00591	Linoleic acid metabolism	9/3289	29/8135	0.8908	1	0.8604	PLA2G4A/CYP3A4/PLA2G2D/CYP2E1/ALOX15/CYP2C8/PLA2G12A/PLA2G2E/PLA2G10	9
KEGG	hsa05030	Cocaine addiction	16/3289	49/8135	0.8972	1	0.8604	CREB1/PRKACB/GNAS/CREB3L4/SLC18A1/CREB5/CDK5R1/ADCY5/CREB3/FOSB/SLC18A2/CREB3L1/GRIN3B/MAOB/GRM2/GRIN2B	16
KEGG	hsa04610	Complement and coagulation cascades	29/3289	85/8135	0.9048	1	0.8604	CFH/CFHR1/CD46/PROCR/MASP2/PROS1/F5/CLU/A2M/SERPINA5/C3/C4BPB/VTN/PROC/CFD/F2R/PLAUR/CR1/KLKB1/C3AR1/F13A1/KNG1/F8/CD55/SERPING1/C1QA/C2/SERPINF2/C4B	29
KEGG	hsa04657	IL-17 signaling pathway	32/3289	94/8135	0.9165	1	0.8604	CASP3/S100A8/MAP3K7/USP25/HSP90B1/CHUK/TRAF3IP2/TBK1/TRAF5/TAB2/CXCL5/S100A9/IL17RB/IKBKB/CSF3/LCN2/MAPK6/MAPK7/MAPK9/TNF/GSK3B/JUND/SRSF1/FOSB/CCL2/CXCL3/CXCL8/S100A7/ELAVL1/IL17RE/TAB3/IL25	32
KEGG	hsa05320	Autoimmune thyroid disease	17/3289	53/8135	0.9184	1	0.8604	HLA-DMB/HLA-DRA/FAS/HLA-DMA/GZMB/HLA-DOA/HLA-DQA1/TSHR/CD86/HLA-DQA2/CD40LG/TG/CD40/HLA-DPA1/HLA-DQB1/CTLA4/IFNA21	17
KEGG	hsa04713	Circadian entrainment	33/3289	97/8135	0.9201	1	0.8604	GNGT2/GUCY1B1/RPS6KA5/GNG10/CREB1/PRKACB/GNG5/CALM3/GNAS/PLCB1/GNAQ/GNB3/GRIA4/CACNA1I/ADCY5/CAMK2G/ITPR1/CALM1/GRIA1/GNB4/GUCY1A1/GNB1/GNG11/PLCB2/PLCB4/ADCY2/CACNA1G/PRKG2/PRKCB/CAMK2D/ADCY3/GRIN2B/MTNR1B	33
KEGG	hsa04622	RIG-I-like receptor signaling pathway	23/3289	70/8135	0.9235	1	0.8604	IFIH1/AZI2/DDX58/MAP3K7/CHUK/TBK1/CYLD/IKBKB/TKFC/MAP3K1/TANK/DDX3X/MAPK9/ATG12/TNF/TBKBP1/DHX58/IFNB1/CXCL8/RIPK1/IFNA21/TRIM25/PIN1	23
KEGG	hsa00592	alpha-Linolenic acid metabolism	7/3289	25/8135	0.9326	1	0.8604	PLA2G4A/PLA2G2D/ACOX3/PLA2G12A/PLA2G2E/PLA2G10/FADS2	7
KEGG	hsa00830	Retinol metabolism	22/3289	68/8135	0.9331	1	0.8604	CYP3A4/DHRS4/RDH11/RDH10/DHRS4L2/ADH1A/PNPLA4/CYP2C8/CYP2B6/ADH6/DGAT1/CYP26B1/CYP1A1/AWAT2/DHRS9/HSD17B6/ADH5/RDH5/RDH13/UGT1A3/UGT2B28/UGT2B11	22
KEGG	hsa00040	Pentose and glucuronate interconversions	10/3289	34/8135	0.934	1	0.8604	RPEL1/UGP2/DHDH/CRYL1/DCXR/XYLB/AKR1A1/UGT1A3/UGT2B28/UGT2B11	10
KEGG	hsa04940	Type I diabetes mellitus	13/3289	43/8135	0.9382	1	0.8604	HLA-DMB/HLA-DRA/FAS/HLA-DMA/GZMB/HLA-DOA/HLA-DQA1/CD86/HLA-DQA2/TNF/HLA-DPA1/HLA-DQB1/ICA1	13
KEGG	hsa03010	Ribosome	55/3289	158/8135	0.9387	1	0.8604	MRPL19/RPS12/MRPL30/RPS6/MRPS18C/MRPL1/RPL37/RPL7/RPL36AL/RSL24D1/RPL15/MRPS16/RPL36A/MRPL12/RPS27L/MRPL3/RPS10-NUDT3/MRPS6/MRPL27/MRPS18A/MRPL10/MRPL21/MRPL18/RPL36/MRPS12/MRPS11/RPL28/MRPL36/MRPS7/RPL23/MRPS14/RPLP2/RPL38/RPL10A/MRPL13/RPS25/MRPL2/RPL36A-HNRNPH2/RPL22/RPL9/MRPL14/MRPL17/RPS8/RPS9/RPL7A/MRPL9/MRPL20/MRPL15/MRPL28/RPS21/RPS27A/RPS20/RPS17/RPL4/RPS26	55
KEGG	hsa00983	Drug metabolism - other enzymes	26/3289	80/8135	0.943	1	0.8604	NME7/CYP3A4/GSTA1/RRM2B/XDH/NME1/CYP2E1/NAT1/UPP2/NME6/HPRT1/GSTA5/CMPK1/CES1/GMPS/TPMT/UPP1/UCK1/GSTA3/DUT/CDA/GSTP1/UGT1A3/UGT2B28/UGT2B11/RRM1	26
KEGG	hsa00140	Steroid hormone biosynthesis	19/3289	61/8135	0.9486	1	0.8604	CYP1B1/HSD17B12/CYP3A4/HSD17B8/AKR1C3/CYP2E1/LRTOMT/AKR1C1/DHRS11/CYP11A1/SRD5A3/HSD3B2/CYP1A1/HSD17B6/COMT/CYP19A1/UGT1A3/UGT2B28/UGT2B11	19
KEGG	hsa04614	Renin-angiotensin system	6/3289	23/8135	0.9506	1	0.8604	PRCP/ATP6AP2/LNPEP/CMA1/THOP1/NLN	6
KEGG	hsa00120	Primary bile acid biosynthesis	4/3289	17/8135	0.9571	1	0.8604	SCP2/HSD17B4/ACOT8/AMACR	4
KEGG	hsa04726	Serotonergic synapse	38/3289	115/8135	0.9587	1	0.8604	CASP3/ITPR2/GNGT2/GNG10/PLA2G4A/PRKACB/ALOX15B/GNG5/TRPC1/GNAS/PLCB1/GNAQ/RAPGEF3/ALOX15/NRAS/MAP2K1/GNB3/SLC18A1/ADCY5/ITPR1/CYP2C8/ALOX12B/KRAS/GNB4/SLC18A2/GNB1/CACNA1F/HTR6/GNG11/HTR3D/PLCB2/PLCB4/HRAS/PTGS1/HTR3E/HTR2C/PRKCB/MAOB	38
KEGG	hsa05203	Viral carcinogenesis	71/3289	204/8135	0.9592	1	0.8604	GTF2H2/RBL1/CASP3/CCND1/HDAC2/GTF2H2C/EIF2AK2/PSMC1/PIK3CA/RBL2/CCNE2/DLG1/SNW1/RB1/CDK1/SP100/PIK3CB/GTF2H1/MAPKAPK2/TRAF5/KAT2B/CREB1/YWHAZ/PIK3R1/PRKACB/C3/CDC42/HDAC10/YWHAB/PIK3R3/MDM2/MRPS18B/GRB2/ACTN4/CREB3L4/IL6ST/STAT5B/NRAS/ATP6V0D1/DDX3X/EP300/USP7/SRF/SND1/SKP2/HNRNPK/CREB5/CDK4/REL/TP53/LYN/PIK3CD/CCND2/UBE3A/CREB3/JAK3/CDK6/KRAS/CHEK1/PXN/BAK1/DDB1/HRAS/STAT5A/CREB3L1/CCNE1/CDKN1B/CCNA1/CDKN2A/HDAC11/GTF2H4	71
KEGG	hsa05150	Staphylococcus aureus infection	31/3289	96/8135	0.9605	1	0.8604	DEFA1/DEFA1B/DEFA3/HLA-DMB/SELPLG/CFH/MASP2/HLA-DRA/HLA-DMA/CAMP/FCGR3B/C3/HLA-DOA/HLA-DQA1/ITGAL/HLA-DQA2/KRT35/CFD/C3AR1/SELP/KRT19/HLA-DPA1/FCGR3A/FPR3/C1QA/HLA-DQB1/KRT10/C2/C4B/KRT17/ICAM1	31
KEGG	hsa00030	Pentose phosphate pathway	8/3289	30/8135	0.9609	1	0.8604	RPEL1/PGM2/FBP1/PRPS2/PGM1/H6PD/PRPS1/RPIA	8
KEGG	hsa04024	cAMP signaling pathway	77/3289	221/8135	0.9638	1	0.8604	PIK3CA/PPP1CB/ROCK1/PIK3CB/PPP1CC/ATP2B1/PDE3B/PLD1/CREB1/PIK3R1/PRKACB/RAC2/ADRB2/ACOX3/ROCK2/AKT3/CALM3/SSTR1/PIK3R3/GNAS/RAP1A/SUCNR1/TSHR/PDE4C/GHSR/ARAP3/CREB3L4/RAPGEF3/F2R/POMC/MAP2K1/RRAS/OXT/PAK1/EP300/GRIA4/CREB5/HCAR1/EDN2/MAPK9/PDE3A/ADCY5/AKT2/PIK3CD/GPHA2/NPR1/TIAM1/CAMK2G/CALM1/CREB3/GRIA1/CNGA3/RAC3/HCN4/CACNA1F/HTR6/PPP1R12A/PLN/ATP1A2/CFTR/DRD5/VAV2/ADCY2/ATP1A3/SLC9A1/AKT1/NPPA/CREB3L1/GRIN3B/CAMK2D/LIPE/NPY/ADCY3/GRIN2B/ATP1A4/MYL9/OXTR	77
KEGG	hsa04911	Insulin secretion	27/3289	86/8135	0.9677	1	0.8604	KCNMB3/CREB1/PRKACB/TRPM4/PDX1/GNAS/KCNMB4/PLCB1/CREB3L4/GNAQ/CREB5/ADCY5/CAMK2G/CREB3/CACNA1F/GNA11/ATP1A2/PLCB2/PLCB4/ADCY2/ATP1A3/RAB3A/CREB3L1/PRKCB/CAMK2D/ADCY3/ATP1A4	27
KEGG	hsa04976	Bile secretion	28/3289	89/8135	0.9688	1	0.8604	HMGCR/CYP3A4/PRKACB/ABCB4/ABCB1/GNAS/SCT/RXRA/ABCC3/NR0B2/SLCO1B3/ADCY5/AQP1/AQP9/ATP1A2/CFTR/ABCC2/SLC4A4/ADCY2/ATP1A3/SLC9A1/SCARB1/ADCY3/UGT1A3/UGT2B28/UGT2B11/ATP1A4/LDLR	28
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	50/3289	150/8135	0.9705	1	0.8604	PPP2R5E/RPS6KA5/PPP2R5A/MYL3/PPP1CB/PPP1CC/ATP2B1/BCL2/CREB1/PRKACB/PPP2R3C/PPP2R1B/ADRB2/AKT3/CALM3/GNAS/PLCB1/CREB3L4/GNAQ/SLC8A2/RAPGEF3/PPP2R3A/MYH7/CACNA2D2/CREB5/PIK3R5/ADCY5/PPP2CA/AKT2/CACNG8/CAMK2G/CALM1/CACNB2/CREB3/PPP2R2A/CACNA1F/SLC8A3/PLN/ATP1A2/PLCB2/PLCB4/ADCY2/ATP1A3/SLC9A1/AKT1/CREB3L1/CAMK2D/ADCY3/KCNQ1/ATP1A4	50
KEGG	hsa05133	Pertussis	23/3289	76/8135	0.975	1	0.8604	CASP3/ITGB1/CASP1/TLR4/CXCL5/LY96/IRAK4/C3/C4BPB/CALM3/MAPK9/TNF/PYCARD/CALM1/MYD88/SERPING1/C1QA/CXCL8/IRF8/C2/CFL2/C4B/CFL1	23
KEGG	hsa04724	Glutamatergic synapse	36/3289	114/8135	0.9803	1	0.8604	HOMER1/SLC38A2/ITPR2/GNGT2/GNG10/PLA2G4A/PPP3R1/SLC38A1/PLD1/PRKACB/GNG5/TRPC1/GLS/PPP3CC/GNAS/PLCB1/GNAQ/GNB3/SHANK3/HOMER2/GRIA4/ADCY5/ITPR1/GRIA1/GNB4/GNB1/GNG11/PLCB2/PLCB4/ADCY2/GRIN3B/PRKCB/GRM2/ADCY3/GRIN2B/GLS2	36
KEGG	hsa04950	Maturity onset diabetes of the young	6/3289	26/8135	0.9809	1	0.8604	PDX1/BHLHA15/MNX1/FOXA3/HES1/HHEX	6
KEGG	hsa00982	Drug metabolism - cytochrome P450	21/3289	72/8135	0.9827	1	0.8604	FMO5/CYP3A4/GSTA1/CYP2E1/ADH1A/ALDH3A1/GSTK1/GSTA5/CYP2C8/CYP2B6/ADH6/FMO1/ALDH3B2/ADH5/MAOB/GSTA3/GSTP1/UGT1A3/UGT2B28/UGT2B11/FMO4	21
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	23/3289	78/8135	0.9834	1	0.8604	CYP1B1/CYP3A4/GSTA1/DHDH/CYP2E1/ADH1A/ALDH3A1/CBR1/GSTK1/AKR1C1/GSTA5/AKR7A2/CYP2B6/ADH6/AKR7L/CYP1A1/ALDH3B2/ADH5/GSTA3/GSTP1/UGT1A3/UGT2B28/UGT2B11	23
KEGG	hsa00053	Ascorbate and aldarate metabolism	7/3289	30/8135	0.9848	1	0.8604	MIOX/ALDH7A1/AKR1A1/ALDH2/UGT1A3/UGT2B28/UGT2B11	7
KEGG	hsa05410	Hypertrophic cardiomyopathy	27/3289	90/8135	0.9849	1	0.8604	ITGA4/PRKAA1/ITGB1/MYL3/TGFB2/LMNA/ITGA1/PRKAB1/ITGA2/SLC8A2/TTN/MYH7/CACNA2D2/PRKAG1/ITGA9/TNF/CACNG8/CACNB2/PRKAG3/DAG1/CACNA1F/SLC8A3/TGFB1/ACTG1/ITGAV/ITGB4/SGCA	27
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	71/3289	212/8135	0.9852	1	0.8604	EGF/RPS6KA3/CCND1/CYP1B1/PIK3CA/HSP90B1/JAK2/RB1/CYP3A4/GSTA1/PIK3CB/SOS2/KPNA5/EIF4EBP1/BCL2/CREB1/PIK3R1/PRKACB/ADRB2/XIAP/EPHX4/AKT3/CDC6/KPNA3/PIK3R3/PTGES3/GNAS/GRB2/RXRA/CREB3L4/STAT5B/NRAS/MAP2K1/PAQR7/SOS1/CREB5/GSTA5/ADCY5/CHRNA3/AKT2/PIK3CD/PAQR8/FGF10/DLL4/CREB3/KPNA6/DLL3/KRAS/FGF2/CYP2B6/CHRNB2/CACNA1F/KPNA2/ADCY2/CYP1A1/AKT1/HRAS/STAT5A/VEGFA/KPNB1/CREB3L1/KLF5/PRKCB/ARNT/GSTA3/ADCY3/UGT1A3/UGT2B28/CHRNA9/UGT2B11/BIRC5	71
KEGG	hsa05414	Dilated cardiomyopathy	29/3289	96/8135	0.9857	1	0.8604	ITGA4/ITGB1/MYL3/PRKACB/TGFB2/LMNA/ITGA1/GNAS/ITGA2/SLC8A2/TTN/MYH7/CACNA2D2/ITGA9/ADCY5/TNF/CACNG8/CACNB2/DAG1/CACNA1F/SLC8A3/PLN/TGFB1/ACTG1/ADCY2/ITGAV/ITGB4/ADCY3/SGCA	29
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/3289	100/8135	0.9886	1	0.8604	PPBP/TNFSF10/CXCL5/PF4/CX3CR1/CCL4L2/CCL4/IL18R1/IL6ST/CCL3L1/CCL18/CCL22/XCL2/IL2RG/TNF/CCR6/CCL3/CXCL9/CSF1R/CCL2/IL10RA/IL6R/CXCL3/CXCL8/CXCR2/CXCR1/CXCR3/TNFRSF1B/IL19/TNFRSF10A	30
KEGG	hsa04727	GABAergic synapse	26/3289	89/8135	0.9897	1	0.8604	SLC38A2/GNGT2/GNG10/SLC38A1/SLC12A5/PRKACB/GABARAP/GNG5/GLS/GABRR1/GNB3/ABAT/PLCL1/ADCY5/GABRP/NSF/GNB4/GNB1/CACNA1F/GNG11/ADCY2/SLC6A11/PRKCB/SLC6A13/ADCY3/GLS2	26
KEGG	hsa04623	Cytosolic DNA-sensing pathway	17/3289	63/8135	0.991	1	0.8604	DDX58/CASP1/CHUK/TBK1/IKBKB/CCL4L2/CCL4/POLR1C/PYCARD/IFNB1/POLR3K/TREX1/POLR1D/POLR3D/RIPK1/IFNA21/POLR3A	17
KEGG	hsa04060	Cytokine-cytokine receptor interaction	100/3289	295/8135	0.992	1	0.8604	PPBP/IFNGR1/INHBA/TNFSF13B/TNFSF10/FAS/BMPR2/IL7R/IL36G/TGFB2/CXCL5/TNFSF4/ACVR1B/GDF7/PF4/IL17RB/IL11RA/CX3CR1/THPO/TNFRSF11B/BMP8B/IFNAR1/IL1RN/TNFRSF8/CCL4L2/CSF3/TNFRSF4/IFNL3/CCL4/BMP6/EPO/CD40LG/IL18R1/IL6ST/EPOR/CCL3L1/GDF15/IL12RB1/CXCL16/IL1RL2/CSH1/BMP3/CCL18/CCL22/XCL2/BMP8A/TNFSF12/ACVR2B/IL2RG/TNF/TNFSF9/CCR6/CCL3/CD40/OSM/TNFRSF9/CXCL9/IL15RA/CSF1R/PRL/ACVR2A/TNFRSF25/IL5RA/IFNB1/CCL2/GDF11/IL10RA/TNFRSF6B/IL6R/IL36B/CXCL3/CXCL8/CXCR2/IL32/TNFRSF13B/TGFB1/CXCR1/IL22/CSH2/IL1RL1/OSMR/IL17RE/CXCR3/TNFRSF1B/IFNA21/ACVRL1/NODAL/EBI3/IL25/CSF2RA/IL1R2/IL3RA/IL19/CTF1/BMP4/CD27/IL21/IL15/NGFR/TNFRSF10A	100
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/3289	77/8135	0.9944	1	0.8604	ITGA4/ITGB1/DSC2/LMNA/ITGA1/JUP/ITGA2/SLC8A2/CACNA2D2/TCF7/ITGA9/CACNG8/CACNB2/DAG1/CACNA1F/SLC8A3/CDH2/ACTG1/ITGAV/ITGB4/SGCA	21
KEGG	hsa04979	Cholesterol metabolism	12/3289	50/8135	0.9953	1	0.8604	APOC1/NPC2/ABCA1/VDAC1/SOAT1/VAPB/VAPA/LRP1/LRPAP1/SCARB1/LPL/LDLR	12
KEGG	hsa04217	Necroptosis	49/3289	159/8135	0.9955	1	0.8604	TRPM7/DNM1L/BIRC3/IFNGR1/BIRC2/CASP1/HMGB1/EIF2AK2/TNFSF10/JAK2/PLA2G4A/FAS/TLR4/TRAF5/BCL2/CYLD/VPS4B/SLC25A4/XIAP/CHMP5/CHMP2B/CFLAR/IFNAR1/VDAC1/STAT5B/ALOX15/FAF1/TLR3/MAPK9/TNF/PYCARD/STAT1/CAMK2G/CHMP4C/JAK3/IFNB1/PARP1/TYK2/STAT4/SLC25A6/SPATA2/STAT5A/CHMP3/RIPK1/CAMK2D/IFNA21/GLUD1/CHMP1A/TNFRSF10A	49
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	18/3289	69/8135	0.9957	1	0.8604	CYP1B1/CYP3A4/GSTA1/CYP2E1/NAT1/SULT1A1/CBR1/GSTK1/GSTA5/CYP2C8/SULT1A3/SULT1A4/CYP1A1/GSTA3/GSTP1/UGT1A3/UGT2B28/UGT2B11	18
KEGG	hsa05171	Coronavirus disease - COVID-19	74/3289	232/8135	0.9974	1	0.8604	IFIH1/RPS12/DDX58/MAP3K7/CASP1/EIF2AK2/PIK3CA/RPS6/CHUK/TLR2/MASP2/TBK1/PIK3CB/RPL37/OAS1/TLR4/TAB2/PIK3R1/IRAK4/RPL7/RPL36AL/C3/RSL24D1/RPL15/PIK3R3/RPL36A/RPS27L/IKBKB/IFNAR1/CSF3/RPS10-NUDT3/IL6ST/CFD/RPL36/OAS2/TLR3/RPL28/C3AR1/MAPK9/ADAM17/RPL23/TNF/SELP/PIK3CD/RPLP2/RPL38/STAT1/RPL10A/F13A1/RPS25/MYD88/TMPRSS2/C1QA/IFNB1/RPL36A-HNRNPH2/CCL2/IL6R/TYK2/RPL22/CXCL8/RPL9/RPS8/RPS9/C2/RPL7A/PRKCB/IFNA21/RPS21/C4B/RPS27A/RPS20/RPS17/RPL4/RPS26	74
KEGG	hsa04723	Retrograde endocannabinoid signaling	44/3289	148/8135	0.9975	1	0.8604	NDUFS1/NDUFA5/ITPR2/GNGT2/GNG10/NDUFC1/PRKACB/NDUFA9/GNG5/PLCB1/GNAQ/NDUFB3/NDUFS7/GABRR1/GNB3/NAPEPLD/NDUFA11/GRIA4/MAPK9/NDUFA13/NDUFB6/ADCY5/NDUFV2/ITPR1/GABRP/NDUFS4/NDUFB5/GRIA1/GNB4/NDUFV3/GNB1/CACNA1F/NDUFA2/MGLL/GNG11/NDUFC2-KCTD14/PLCB2/PLCB4/ADCY2/NDUFB2/NDUFAB1/PRKCB/ADCY3/NDUFS8	44
KEGG	hsa04744	Phototransduction	5/3289	29/8135	0.9981	1	0.8604	CALM3/GRK1/CALM1/GNB1/PDE6G	5
KEGG	hsa00910	Nitrogen metabolism	2/3289	17/8135	0.9981	1	0.8604	CA7/GLUD1	2
KEGG	hsa05032	Morphine addiction	24/3289	91/8135	0.9983	1	0.8604	GNGT2/GNG10/PDE3B/GRK6/OPRM1/PRKACB/GNG5/GNAS/PDE4C/GABRR1/GNB3/PDE2A/PDE3A/ADCY5/GRK5/GABRP/GNB4/GNB1/GNG11/ADCY2/GRK4/PRKCB/ADCY3/PDE8A	24
KEGG	hsa04742	Taste transduction	21/3289	86/8135	0.9994	1	0.8604	PRKACB/TAS2R19/P2RY1/TAS2R14/TAS2R31/PLCB1/TAS2R30/TAS2R20/GNB3/SCN3A/TAS2R40/HCN4/TAS2R46/HTR3D/TAS2R5/PLCB2/PLCB4/ASIC2/TAS1R1/HTR3E/SCNN1G	21
KEGG	hsa05033	Nicotine addiction	7/3289	40/8135	0.9995	1	0.8604	GABRR1/GRIA4/GABRP/GRIA1/CHRNB2/GRIN3B/GRIN2B	7
KEGG	hsa04020	Calcium signaling pathway	72/3289	240/8135	0.9997	1	0.8604	PHKB/EGF/FGF19/ITPR2/GNA15/PPP3R1/ATP2B1/MCOLN3/PRKACB/SLC25A4/ADRB2/CYSLTR1/CAMK1D/CALM3/PPP3CC/GNAS/PDGFRA/VDAC1/PDGFA/PLCB1/GNAQ/SLC8A2/F2R/PHKG2/TACR1/MCOLN2/CACNA1I/MCU/CAMK2G/FGFR1/ITPR1/CALM1/RET/PPIF/FGF10/FGF2/PLCD3/CACNA1F/HTR6/SLC8A3/PLN/GNA11/VEGFB/KDR/PDGFRB/PLCZ1/PLCB2/DRD5/PLCB4/ADCY2/HRH1/P2RX6/SLC25A6/SPHK1/CACNA1G/ORAI3/SPHK2/VEGFA/ITPKC/HTR2C/PRKCB/CAMK2D/ASPH/EDNRB/CD38/ADCY3/ITPKB/TBXA2R/CYSLTR2/MET/PHKA1/OXTR	72
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	10/3289	66/8135	1	1	0.8604	SEPSECS/YARS2/IARS2/PSTK/MTFMT/FARSB/RARS2/SARS2/TARS2/GATB	10
KEGG	hsa04613	Neutrophil extracellular trap formation	45/3289	190/8135	1	1	0.8604	CLCN3/MAP3K7/HDAC2/CASP1/SELPLG/HMGB1/PIK3CA/TLR2/ELANE/PIK3CB/TLR4/CAMP/FCGR3B/PIK3R1/AGER/RAC2/SLC25A4/C3/HDAC10/AKT3/PIK3R3/VDAC1/ITGAL/PLCB1/MAP2K1/CR1/CASP4/ATG7/SELP/AKT2/PIK3CD/HAT1/PPIF/FCGR3A/FPR3/AQP9/CYBA/ACTG1/PLCB2/PLCB4/SLC25A6/AKT1/PRKCB/HDAC11/NCF2	45
KEGG	hsa05034	Alcoholism	43/3289	187/8135	1	1	0.8604	HDAC2/GNGT2/GNG10/PPP1CB/PPP1CC/SOS2/CREB1/PRKACB/CAMKK1/GNG5/HDAC10/SLC29A2/CALM3/SHC4/PKIA/GNAS/GRB2/CREB3L4/SLC29A3/NRAS/MAP2K1/GNB3/SOS1/SLC18A1/CREB5/ADCY5/HAT1/CALM1/CREB3/KRAS/FOSB/GNB4/SLC18A2/GNB1/GNG11/SLC29A1/HRAS/CREB3L1/GRIN3B/MAOB/NPY/GRIN2B/HDAC11	43
KEGG	hsa05206	MicroRNAs in cancer	82/3289	310/8135	1	1	0.8604	CCNG1/CASP3/BMI1/COMMD3-BMI1/CCND1/HDAC2/CYP1B1/ATM/PIK3CA/RPS6KA5/CCNE2/ROCK1/BMPR2/PIK3CB/SOS2/PTEN/ZEB1/CD44/MDM4/BCL2/APC/PIK3R1/TGFB2/SIRT1/PDCD4/ST14/ABCB1/PIK3R3/SHC4/GLS/BMF/KIF23/IKBKB/MDM2/PDGFRA/GRB2/PDGFA/EZR/SPRY2/FZD3/PIM1/MAPK7/THBS1/NRAS/MAP2K1/EP300/SOS1/HNRNPK/CRKL/TNR/TP53/PIK3CD/CCND2/RASSF1/CDK6/KRAS/FOXP1/DDIT4/HMOX1/PRKCE/NOTCH4/DICER1/TNN/EFNA4/PDGFRB/BAK1/MCL1/APC2/BCL2L11/HRAS/VEGFA/WNT3/PRKCB/CCNE1/CDKN1B/CDKN2A/E2F3/BRCA1/E2F2/MET/PAK4/GLS2	82
KEGG	hsa05322	Systemic lupus erythematosus	24/3289	136/8135	1	1	0.8604	RO60/HLA-DMB/SSB/HLA-DRA/ELANE/HLA-DMA/FCGR3B/C3/HLA-DOA/HLA-DQA1/SNRPD1/CD86/ACTN4/HLA-DQA2/CD40LG/TNF/CD40/HLA-DPA1/FCGR3A/C1QA/HLA-DQB1/C2/C4B/GRIN2B	24
KEGG	hsa04080	Neuroactive ligand-receptor interaction	90/3289	353/8135	1	1	0.8604	LPAR6/P2RY2/ADRA2A/OPRM1/RXFP3/ADRB2/HRH3/P2RY1/C3/CYSLTR1/LYNX1/PTGDR/VIPR1/PRSS3/SSTR1/SCT/TSHR/GHSR/PRSS1/HCRTR2/GABRR1/P2RY6/CHRNB3/GLRA2/F2R/POMC/CSH1/OXT/P2RY10/TACR1/GRIA4/GALP/GLRA3/EDN2/C3AR1/GPR35/THRB/CHRNA3/ADORA3/GPHA2/S1PR1/KNG1/GAL/LPAR3/GABRP/GLRA1/FPR3/PRL/UCN2/GRIA1/HCRTR1/CHRNB2/HTR6/GHRHR/TAC3/NPB/UCN/ADRA2C/APLN/NR3C1/DRD5/PTGIR/P2RY8/HRH1/P2RX6/CSH2/CORT/CHRNE/ADM/MC5R/HTR2C/GRIN3B/RLN3/RLN1/RXFP2/GRM2/NPY/EDNRB/NPY4R/NPY4R2/GRIN2B/TBXA2R/CYSLTR2/CHRNA10/CHRNA9/GPR156/MTNR1B/ADRA2B/NPBWR1/OXTR	90
KEGG	hsa04740	Olfactory transduction	61/3289	440/8135	1	1	0.8604	RGS2/PRKACB/OR9G1/OR52K2/OR4A16/CALM3/OR4C15/OR2Y1/OR4C45/SLC8A2/OR1L8/PDE2A/OR7D4/OR10C1/OR56A1/OR2A7/OR2T12/CAMK2G/CALM1/OR51M1/OR51T1/OR2L13/CNGA3/OR11A1/OR8G5/OR10G3/OR52N4/GNB1/OR9K2/OR2M2/SLC8A3/OR13H1/OR2T27/OR9A4/OR6N1/OR1D4/OR2H1/OR8S1/OR1A2/PRKG2/OR1A1/OR7G2/OR6V1/OR10P1/OR6C74/OR2T1/CAMK2D/OR2B11/OR10A6/OR52I2/OR1J4/ADCY3/OR51F2/OR2H2/SLC24A4/OR2AG2/OR10J5/OR5C1/OR8I2/OR10A5/OR6B2	61