ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 15/622 100/8135 0.008627 0.9049 0.9049 CXCL14/CCL21/CCL5/TNFRSF1B/CCL14/CCR6/IL18RAP/IL37/CCL11/ACKR4/CCR1/IL20RA/CXCL12/CXCR1/CXCL11 15 KEGG hsa04114 Oocyte meiosis 18/622 131/8135 0.01055 0.9049 0.9049 PPP3CA/ANAPC1/CPEB3/PPP2R5D/AR/SPDYE5/MAPK11/MAD1L1/PTTG2/ITPR3/PPP2R5A/CPEB2/SLK/CAMK2B/PKMYT1/ITPR2/SPDYE18/IGF1R 18 KEGG hsa01210 2-Oxocarboxylic acid metabolism 5/622 19/8135 0.01214 0.9049 0.9049 BCAT2/GPT/ACO1/ACY1/IDH3G 5 KEGG hsa05224 Breast cancer 19/622 147/8135 0.01628 0.9049 0.9049 MAP2K2/WNT2B/CDK6/FGF20/DLL3/EGF/FRAT1/NOTCH1/KIT/BRCA1/AXIN1/GSK3B/SHC3/CDK4/FGF9/BRAF/HEY2/FGFR1/IGF1R 19 KEGG hsa00140 Steroid hormone biosynthesis 10/622 61/8135 0.01639 0.9049 0.9049 HSD11B1L/UGT2B7/HSD17B8/HSD17B3/SRD5A2/CYP11B1/UGT2A3/UGT2B15/CYP21A2/HSD3B2 10 KEGG hsa04060 Cytokine-cytokine receptor interaction 33/622 295/8135 0.01681 0.9049 0.9049 CXCL14/IFNA17/IFNA4/CCL21/CCL5/EDA/TNFRSF1B/CCL14/CCR6/IL18RAP/LEP/IL37/IL21/GDF7/BMP4/CCL11/IL17RC/INHBA/TNFRSF19/ACKR4/CCR1/IL20RA/INHBB/CXCL12/IFNGR1/NGF/IFNA6/GDF5/CXCR1/TNFRSF6B/BMP15/BMP10/CXCL11 33 KEGG hsa04151 PI3K-Akt signaling pathway 38/622 354/8135 0.01995 0.9205 0.9205 MAGI1/IFNA17/IFNA4/MAP2K2/CDK6/PHLPP2/TCL1B/FGF20/PIK3R5/PPP2R5D/COL4A1/PPP2R2D/INSR/ITGA3/TNC/EGF/LAMA5/GNG7/SGK2/PKN1/TNR/KIT/BRCA1/GSK3B/PPP2R5A/ITGA5/JAK2/ANGPT2/CDK4/PCK2/FGF9/LAMC2/NGF/IFNA6/MLST8/FGFR1/CREB3L2/IGF1R 38 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 18/622 143/8135 0.02426 0.9328 0.9328 ID4/MAP2K2/WNT2B/NANOG/HAND1/ID3/BMP4/POU5F1B/MAPK11/INHBA/SMAD4/AXIN1/GSK3B/SMAD2/JAK2/INHBB/FGFR1/IGF1R 18 KEGG hsa04350 TGF-beta signaling pathway 13/622 94/8135 0.02599 0.9328 0.9328 ID4/CHRD/ID3/GDF7/BMP4/INHBA/SMAD4/SMAD2/E2F5/E2F4/NEO1/INHBB/GDF5 13 KEGG hsa04730 Long-term depression 9/622 60/8135 0.03729 0.9992 0.9992 GRIA1/MAP2K2/CRHR1/GRIA3/ITPR3/BRAF/GNA11/ITPR2/IGF1R 9 KEGG hsa04520 Adherens junction 10/622 71/8135 0.04253 0.9992 0.9992 BAIAP2/RAC2/INSR/ACTG1/SMAD4/PTPRB/NECTIN4/RAC3/FGFR1/IGF1R 10 KEGG hsa04020 Calcium signaling pathway 26/622 240/8135 0.04402 0.9992 0.9992 RYR3/P2RX1/HTR2A/PPP3CA/FGF20/TNNC1/HTR5A/ORAI3/TACR2/MCOLN1/CACNA1B/EGF/PTGER1/CACNA1S/P2RX5/ITPR3/HTR6/FGF9/ATP2A3/CAMK2B/MCOLN3/NGF/FGFR1/GNA11/CYSLTR2/ITPR2 26 KEGG hsa04934 Cushing syndrome 18/622 155/8135 0.04855 0.9992 0.9992 MAP2K2/WNT2B/CRHR1/CDK6/PDE8B/CACNA1S/AXIN1/GSK3B/ITPR3/CYP11B1/CDK4/BRAF/CYP21A2/CAMK2B/GNA11/HSD3B2/ITPR2/CREB3L2 18 KEGG hsa04110 Cell cycle 15/622 126/8135 0.0567 0.9992 0.9992 CDK6/TFDP2/ANAPC1/MCM3/STAG1/MCM5/MAD1L1/SMAD4/GSK3B/PTTG2/SMAD2/CDK4/E2F5/E2F4/PKMYT1 15 KEGG hsa04927 Cortisol synthesis and secretion 9/622 65/8135 0.05773 0.9992 0.9992 PDE8B/CACNA1S/ITPR3/CYP11B1/CYP21A2/GNA11/HSD3B2/ITPR2/CREB3L2 9 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 13/622 106/8135 0.05996 0.9992 0.9992 ARHGEF1/RXRB/CASR/SOST/ITPR3/PTH1R/RXRG/BRAF/FGFR1/GNA11/NACA/ITPR2/CREB3L2 13 KEGG hsa04080 Neuroactive ligand-receptor interaction 35/622 353/8135 0.0659 0.9992 0.9992 HTR1F/GPHA2/P2RX1/EDN1/UCN3/GRIA1/HTR2A/P2RY6/CRHR1/OPRL1/GRIK3/SSTR4/GRM3/HTR5A/CHRNA4/GABRB1/S1PR2/PATE2/LEP/F2RL3/GRIA3/TACR2/KNG1/PTGER1/GHRHR/NR3C1/P2RX5/PTH1R/GNRH1/HTR6/C5AR1/LYPD6/SCT/CYSLTR2/GRIN3A 35 KEGG hsa04728 Dopaminergic synapse 15/622 132/8135 0.07833 0.9992 0.9992 GRIA1/PPP3CA/ARNTL/PPP2R5D/PPP2R2D/GRIA3/CACNA1B/GNG7/MAPK11/GSK3B/ITPR3/PPP2R5A/CAMK2B/ITPR2/CREB3L2 15 KEGG hsa05033 Nicotine addiction 6/622 40/8135 0.08125 0.9992 0.9992 GRIA1/CHRNA4/GABRB1/GRIA3/CACNA1B/GRIN3A 6 KEGG hsa05219 Bladder cancer 6/622 41/8135 0.08936 0.9992 0.9992 MAP2K2/UPK3A/MMP9/EGF/CDK4/BRAF 6 KEGG hsa00270 Cysteine and methionine metabolism 7/622 51/8135 0.09146 0.9992 0.9992 DNMT1/GCLM/BCAT2/IL4I1/MTR/MPST/LDHAL6A 7 KEGG hsa04662 B cell receptor signaling pathway 10/622 82/8135 0.09414 0.9992 0.9992 MAP2K2/PPP3CA/FCGR2B/RAC2/LILRB3/GSK3B/LILRA2/LILRB2/RAC3/LILRA6 10 KEGG hsa04062 Chemokine signaling pathway 20/622 192/8135 0.09636 0.9992 0.9992 CXCL14/CCL21/CCL5/HCK/PIK3R5/CCL14/CCR6/GRK6/RAC2/GNG7/CCL11/GSK3B/SHC3/JAK2/CCR1/BRAF/CXCL12/RAC3/CXCR1/CXCL11 20 KEGG hsa05218 Melanoma 9/622 72/8135 0.09663 0.9992 0.9992 MAP2K2/CDK6/FGF20/EGF/CDK4/FGF9/BRAF/FGFR1/IGF1R 9 KEGG hsa04620 Toll-like receptor signaling pathway 12/622 104/8135 0.09846 0.9992 0.9992 IFNA17/IFNA4/CCL5/MAP2K2/CTSK/MAPK11/CD80/MAP2K3/TOLLIP/TICAM2/IFNA6/CXCL11 12 KEGG hsa00730 Thiamine metabolism 3/622 15/8135 0.1017 0.9992 0.9992 AK7/AK8/ALPL 3 KEGG hsa05205 Proteoglycans in cancer 21/622 205/8135 0.1027 0.9992 0.9992 MAP2K2/WNT2B/ARHGEF1/HSPG2/NANOG/MMP9/ACTG1/MAPK11/ITPR3/ITGA5/DROSHA/SMAD2/TFAP4/CTSL/BRAF/FLNC/ANK1/CAMK2B/FGFR1/ITPR2/IGF1R 21 KEGG hsa04929 GnRH secretion 8/622 64/8135 0.1132 0.9992 0.9992 MAP2K2/KCNN1/CACNA1S/ITPR3/GNRH1/KCNJ11/GNA11/ITPR2 8 KEGG hsa03460 Fanconi anemia pathway 7/622 54/8135 0.1154 0.9992 0.9992 RMI2/BRCA1/FAAP100/FANCM/REV3L/RPA4/ERCC4 7 KEGG hsa01230 Biosynthesis of amino acids 9/622 75/8135 0.117 0.9992 0.9992 ENO4/PYCR3/BCAT2/MTR/ASL/GPT/ACO1/ACY1/IDH3G 9 KEGG hsa04911 Insulin secretion 10/622 86/8135 0.1194 0.9992 0.9992 SNAP25/KCNN1/CACNA1S/ITPR3/KCNJ11/KCNMB2/CAMK2B/STX1A/GNA11/CREB3L2 10 KEGG hsa05210 Colorectal cancer 10/622 86/8135 0.1194 0.9992 0.9992 MAP2K2/RAC2/EGF/RALGDS/SMAD4/AXIN1/GSK3B/SMAD2/BRAF/RAC3 10 KEGG hsa04071 Sphingolipid signaling pathway 13/622 119/8135 0.1211 0.9992 0.9992 MAP2K2/PPP2R5D/S1PR2/RAC2/PPP2R2D/SMPD1/KNG1/CERS4/MAPK11/FCER1G/PPP2R5A/RAC3/SMPD2 13 KEGG hsa04015 Rap1 signaling pathway 21/622 210/8135 0.1231 0.9992 0.9992 MAGI1/MAP2K2/FGF20/PRKD2/RAC2/F2RL3/INSR/EGF/ACTG1/MAPK11/RALGDS/KIT/ANGPT2/MAP2K3/FGF9/BRAF/NGF/RAC3/FGFR1/SKAP1/IGF1R 21 KEGG hsa05212 Pancreatic cancer 9/622 76/8135 0.1243 0.9992 0.9992 CDK6/RAC2/EGF/RALGDS/SMAD4/SMAD2/CDK4/BRAF/RAC3 9 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 9/622 77/8135 0.1319 0.9992 0.9992 ITGA3/ACTG1/CACNA1S/ITGA5/PKP2/DSP/ATP2A3/CACNB1/DSC2 9 KEGG hsa05170 Human immunodeficiency virus 1 infection 21/622 212/8135 0.1319 0.9992 0.9992 IFNA17/IFNA4/MAP2K2/PPP3CA/APOBEC3B/TNFRSF1B/RAC2/GNG7/MAPK11/HLA-E/ITPR3/AP1G1/APOBEC3G/APOBEC3F/MAP2K3/APOBEC3A/RAC3/IFNA6/AP1M2/GNA11/ITPR2 21 KEGG hsa00120 Primary bile acid biosynthesis 3/622 17/8135 0.136 0.9992 0.9992 CYP8B1/ACOT8/CYP27A1 3 KEGG hsa00350 Tyrosine metabolism 5/622 36/8135 0.1368 0.9992 0.9992 AOX1/ADH4/IL4I1/GSTZ1/HGD 5 KEGG hsa00760 Nicotinate and nicotinamide metabolism 5/622 36/8135 0.1368 0.9992 0.9992 NT5C2/AOX1/NT5DC4/SIRT3/SIRT6 5 KEGG hsa03030 DNA replication 5/622 36/8135 0.1368 0.9992 0.9992 MCM3/MCM5/POLA1/RFC2/RPA4 5 KEGG hsa05163 Human cytomegalovirus infection 22/622 225/8135 0.1381 0.9992 0.9992 IFNA17/IFNA4/CCL5/MAP2K2/CDK6/PPP3CA/ARHGEF1/RAC2/GNG7/PTGER1/MAPK11/HLA-E/GSK3B/ITPR3/CCR1/CDK4/CXCL12/RAC3/IFNA6/GNA11/ITPR2/CREB3L2 22 KEGG hsa05225 Hepatocellular carcinoma 17/622 168/8135 0.1425 0.9992 0.9992 MAP2K2/WNT2B/CDK6/SMARCD2/FRAT1/ACTG1/SMAD4/AXIN1/TERC/TXNRD2/GSK3B/SHC3/SMARCA4/SMAD2/CDK4/BRAF/IGF1R 17 KEGG hsa00830 Retinol metabolism 8/622 68/8135 0.1459 0.9992 0.9992 CYP26B1/UGT2B7/AOX1/ADH4/UGT2A3/UGT2B15/RDH5/CYP26C1 8 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/622 27/8135 0.1472 0.9992 0.9992 FUT7/ABO/B3GALT5/ST3GAL3 4 KEGG hsa04725 Cholinergic synapse 12/622 113/8135 0.1535 0.9992 0.9992 PIK3R5/KCNJ18/CHRNA4/CACNA1B/GNG7/CACNA1S/ITPR3/JAK2/CAMK2B/GNA11/ITPR2/CREB3L2 12 KEGG hsa00061 Fatty acid biosynthesis 3/622 18/8135 0.1544 0.9992 0.9992 ACSF3/HSD17B8/ACACA 3 KEGG hsa00280 Valine, leucine and isoleucine degradation 6/622 48/8135 0.1574 0.9992 0.9992 ACSF3/AOX1/BCAT2/IL4I1/ACADS/HMGCL 6 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 19/622 194/8135 0.1576 0.9992 0.9992 IFNA17/IFNA4/MAP2K2/CDK6/HCK/PPP3CA/PIK3R5/GNG7/MAPK11/HLA-E/GSK3B/ITPR3/JAK2/ANGPT2/CCR1/CDK4/IFNGR1/IFNA6/ITPR2 19 KEGG hsa00650 Butanoate metabolism 4/622 28/8135 0.162 0.9992 0.9992 ACSM5/ACSM6/ACADS/HMGCL 4 KEGG hsa05226 Gastric cancer 15/622 149/8135 0.1655 0.9992 0.9992 MAP2K2/WNT2B/FGF20/RXRB/EGF/FRAT1/SMAD4/AXIN1/TERC/GSK3B/SHC3/SMAD2/RXRG/FGF9/BRAF 15 KEGG hsa04726 Serotonergic synapse 12/622 115/8135 0.1676 0.9992 0.9992 HTR1F/HTR2A/HTR5A/GABRB1/CYP2D7/CACNA1B/GNG7/CACNA1S/ITPR3/HTR6/BRAF/ITPR2 12 KEGG hsa00982 Drug metabolism - cytochrome P450 8/622 72/8135 0.1827 0.9992 0.9992 UGT2B7/CYP2D7/AOX1/ADH4/FMO5/UGT2A3/UGT2B15/FMO1 8 KEGG hsa05165 Human papillomavirus infection 30/622 331/8135 0.1863 0.9992 0.9992 MAGI1/IFNA17/IFNA4/MAP2K2/WNT2B/CDK6/PPP2R5D/PATJ/COL4A1/PPP2R2D/ITGA3/TNC/EGF/LAMA5/HLA-E/TNR/NOTCH1/RBPJL/AXIN1/GSK3B/HES3/PPP2R5A/ITGA5/TADA3/CDK4/LAMC2/IRF1/HEY2/IFNA6/CREB3L2 30 KEGG hsa00020 Citrate cycle (TCA cycle) 4/622 30/8135 0.1932 0.9992 0.9992 ACO1/PCK2/OGDH/IDH3G 4 KEGG hsa04935 Growth hormone synthesis, secretion and action 12/622 119/8135 0.1975 0.9992 0.9992 MAP2K2/MAPK11/GHRHR/CACNA1S/GSK3B/ITPR3/SHC3/JAK2/MAP2K3/GNA11/ITPR2/CREB3L2 12 KEGG hsa01232 Nucleotide metabolism 9/622 85/8135 0.2 0.9992 0.9992 GUK1/AMPD1/NT5C2/UCK1/ENTPD5/AK7/AK8/AMPD2/NT5DC4 9 KEGG hsa04650 Natural killer cell mediated cytotoxicity 13/622 131/8135 0.2007 0.9992 0.9992 KIR3DL3/IFNA17/IFNA4/MAP2K2/PPP3CA/RAC2/FCER1G/HLA-E/SHC3/BRAF/IFNGR1/RAC3/IFNA6 13 KEGG hsa05017 Spinocerebellar ataxia 14/622 143/8135 0.2032 0.9992 0.9992 GRIA1/MYOD1/ATG13/CIC/PSMC2/GRIA3/KCNC3/RBPJL/ITPR3/TWNK/ATP2A3/ATXN8OS/GRIN3A/ITPR2 14 KEGG hsa05215 Prostate cancer 10/622 97/8135 0.2057 0.9992 0.9992 MAP2K2/AR/MMP9/EGF/SRD5A2/GSK3B/BRAF/FGFR1/CREB3L2/IGF1R 10 KEGG hsa04310 Wnt signaling pathway 16/622 167/8135 0.2065 0.9992 0.9992 WNT2B/PPP3CA/RAC2/LGR6/FRAT1/INVS/SMAD4/AXIN1/SOST/GSK3B/CBY1/CHD8/RSPO3/CAMK2B/RAC3/ROR2 16 KEGG hsa04066 HIF-1 signaling pathway 11/622 109/8135 0.2101 0.9992 0.9992 EDN1/MAP2K2/ENO4/VHL/INSR/EGF/LDHAL6A/ANGPT2/IFNGR1/CAMK2B/IGF1R 11 KEGG hsa04218 Cellular senescence 15/622 156/8135 0.2121 0.9992 0.9992 MAP2K2/CDK6/PPP3CA/MAPK11/GATA4/HLA-E/ITPR3/SMAD2/CDK4/CAPN1/E2F5/E2F4/MAP2K3/NBN/ITPR2 15 KEGG hsa05214 Glioma 8/622 75/8135 0.2127 0.9992 0.9992 MAP2K2/CDK6/EGF/SHC3/CDK4/BRAF/CAMK2B/IGF1R 8 KEGG hsa01522 Endocrine resistance 10/622 98/8135 0.2147 0.9992 0.9992 MAP2K2/DLL3/CYP2D7/MMP9/MAPK11/NOTCH1/SHC3/CDK4/BRAF/IGF1R 10 KEGG hsa04360 Axon guidance 17/622 182/8135 0.2274 0.9992 0.9992 PPP3CA/RAC2/EPHB2/SRGAP2/GDF7/SLIT1/SEMA3C/NTN3/GSK3B/EPHB6/RND1/NEO1/CXCL12/CAMK2B/RAC3/SLIT3/SRGAP1 17 KEGG hsa00220 Arginine biosynthesis 3/622 22/8135 0.2344 0.9992 0.9992 ASL/GPT/ACY1 3 KEGG hsa04072 Phospholipase D signaling pathway 14/622 148/8135 0.2405 0.9992 0.9992 MAP2K2/PIK3R5/CYTH1/GRM3/DGKQ/INSR/EGF/RALGDS/FCER1G/DNM1/KIT/SHC3/DGKI/CXCR1 14 KEGG hsa04130 SNARE interactions in vesicular transport 4/622 33/8135 0.2429 0.9992 0.9992 VAMP5/YKT6/STX1A/STX6 4 KEGG hsa04010 MAPK signaling pathway 26/622 294/8135 0.2447 0.9992 0.9992 MAP2K2/PPP3CA/FGF20/RAC2/DUSP2/INSR/MAPKAPK5/CACNA1B/EGF/MAPK11/CACNA1S/KIT/ANGPT2/MAP4K4/DUSP10/MAP2K3/FGF9/MAP3K6/BRAF/FLNC/NGF/CACNB1/RAC3/FGFR1/STMN1/IGF1R 26 KEGG hsa05410 Hypertrophic cardiomyopathy 9/622 90/8135 0.2488 0.9992 0.9992 EDN1/TNNC1/ITGA3/ACTG1/CACNA1S/ITGA5/MYL2/ATP2A3/CACNB1 9 KEGG hsa04720 Long-term potentiation 7/622 67/8135 0.25 0.9992 0.9992 GRIA1/MAP2K2/PPP3CA/ITPR3/BRAF/CAMK2B/ITPR2 7 KEGG hsa04914 Progesterone-mediated oocyte maturation 10/622 102/8135 0.2518 0.9992 0.9992 ANAPC1/CPEB3/SPDYE5/MAPK11/MAD1L1/CPEB2/BRAF/PKMYT1/SPDYE18/IGF1R 10 KEGG hsa05161 Hepatitis B 15/622 162/8135 0.256 0.9992 0.9992 IFNA17/IFNA4/MAP2K2/HSPG2/MMP9/MAPK11/SMAD4/JAK2/MAP2K3/BRAF/SLC10A1/TICAM2/IFNA6/DDX3X/CREB3L2 15 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 14/622 150/8135 0.2561 0.9992 0.9992 KCNE1/KCNE1B/PIK3R5/TNNC1/PPP2R5D/PPP2R2D/MAPK11/CACNA1S/PPP2R5A/MYL2/ATP2A3/CAMK2B/CACNB1/CREB3L2 14 KEGG hsa01212 Fatty acid metabolism 6/622 57/8135 0.2682 0.9992 0.9992 ACSF3/ELOVL5/HSD17B8/ACADS/ACACA/TECR 6 KEGG hsa05222 Small cell lung cancer 9/622 92/8135 0.2694 0.9992 0.9992 CDK6/COL4A1/RXRB/ITGA3/LAMA5/TRAF4/CDK4/RXRG/LAMC2 9 KEGG hsa00230 Purine metabolism 12/622 128/8135 0.2726 0.9992 0.9992 GUCY2F/PDE6A/GUK1/AMPD1/PDE8B/NT5C2/ENTPD5/AK7/AK8/AMPD2/NT5DC4/PDE9A 12 KEGG hsa05031 Amphetamine addiction 7/622 69/8135 0.274 0.9992 0.9992 GRIA1/PPP3CA/GRIA3/CAMK2B/STX1A/GRIN3A/CREB3L2 7 KEGG hsa04510 Focal adhesion 18/622 201/8135 0.2752 0.9992 0.9992 DOCK1/RAC2/COL4A1/ITGA3/TNC/EGF/LAMA5/ACTG1/TNR/GSK3B/SHC3/ITGA5/MYL2/BRAF/FLNC/LAMC2/RAC3/IGF1R 18 KEGG hsa04912 GnRH signaling pathway 9/622 93/8135 0.2799 0.9992 0.9992 MAP2K2/MAPK11/CACNA1S/ITPR3/GNRH1/MAP2K3/CAMK2B/GNA11/ITPR2 9 KEGG hsa04622 RIG-I-like receptor signaling pathway 7/622 70/8135 0.2863 0.9992 0.9992 IFNA17/IFNA4/MAPK11/PIN1/TKFC/IFNA6/DDX3X 7 KEGG hsa00620 Pyruvate metabolism 5/622 47/8135 0.2888 0.9992 0.9992 ADH4/LDHAL6A/LDHD/ACACA/PCK2 5 KEGG hsa03420 Nucleotide excision repair 5/622 47/8135 0.2888 0.9992 0.9992 ERCC6/RFC2/RPA4/GTF2H4/ERCC4 5 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/622 14/8135 0.291 0.9992 0.9992 CHST4/ST3GAL3 2 KEGG hsa04330 Notch signaling pathway 6/622 59/8135 0.2951 0.9992 0.9992 DLL3/NOTCH1/RBPJL/DTX2/HEY2/NUMBL 6 KEGG hsa04722 Neurotrophin signaling pathway 11/622 119/8135 0.3004 0.9992 0.9992 MAP2K2/MAPK11/MATK/GSK3B/SHC3/KIDINS220/BEX3/BRAF/CAMK2B/NGF/SH2B1 11 KEGG hsa04922 Glucagon signaling pathway 10/622 107/8135 0.301 0.9992 0.9992 PPP3CA/ITPR3/PPP4C/LDHAL6A/ACACA/PCK2/PRMT1/CAMK2B/ITPR2/CREB3L2 10 KEGG hsa04810 Regulation of actin cytoskeleton 19/622 218/8135 0.3086 0.9992 0.9992 BAIAP2/MYH11/DOCK1/MAP2K2/ARHGEF1/FGF20/MYH14/RAC2/ITGA3/KNG1/EGF/ACTG1/ITGA5/MYL2/FGF9/BRAF/CXCL12/RAC3/FGFR1 19 KEGG hsa05223 Non-small cell lung cancer 7/622 72/8135 0.3111 0.9992 0.9992 MAP2K2/CDK6/RXRB/EGF/CDK4/RXRG/BRAF 7 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 4/622 37/8135 0.3127 0.9992 0.9992 IL4I1/ASL/GPT/GFPT1 4 KEGG hsa01250 Biosynthesis of nucleotide sugars 4/622 37/8135 0.3127 0.9992 0.9992 GMPPB/PMM1/NAGK/GFPT1 4 KEGG hsa05216 Thyroid cancer 4/622 37/8135 0.3127 0.9992 0.9992 MAP2K2/RXRB/RXRG/BRAF 4 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 5/622 49/8135 0.3195 0.9992 0.9992 GMPPB/CYB5R3/PMM1/NAGK/GFPT1 5 KEGG hsa04919 Thyroid hormone signaling pathway 11/622 121/8135 0.3197 0.9992 0.9992 MAP2K2/MED16/RXRB/ACTG1/BMP4/GATA4/NOTCH1/GSK3B/RXRG/ATP2A3/DIO2 11 KEGG hsa04270 Vascular smooth muscle contraction 12/622 134/8135 0.327 0.9992 0.9992 EDN1/MYH11/MAP2K2/ARHGEF1/MYH14/CACNA1S/ITPR3/BRAF/KCNMB2/PLA2G2F/GNA11/ITPR2 12 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 9/622 98/8135 0.3337 0.9992 0.9992 HTR2A/KNG1/MAPK11/ITPR3/MAP2K3/ASIC2/CAMK2B/NGF/ITPR2 9 KEGG hsa04925 Aldosterone synthesis and secretion 9/622 98/8135 0.3337 0.9992 0.9992 PRKD2/CACNA1S/ITPR3/CYP21A2/CAMK2B/GNA11/HSD3B2/ITPR2/CREB3L2 9 KEGG hsa04260 Cardiac muscle contraction 8/622 87/8135 0.3471 0.9992 0.9992 TNNC1/CACNA1S/MYL2/CYC1/ATP2A3/CACNB1/COX7A1/COX4I2 8 KEGG hsa00430 Taurine and hypotaurine metabolism 2/622 16/8135 0.349 0.9992 0.9992 FMO5/FMO1 2 KEGG hsa03250 Viral life cycle - HIV-1 6/622 63/8135 0.3504 0.9992 0.9992 APOBEC3B/APOBEC3G/APOBEC3F/PIN1/APOBEC3A/TSG101 6 KEGG hsa00330 Arginine and proline metabolism 5/622 51/8135 0.3505 0.9992 0.9992 AZIN2/AOC1/CNDP2/PYCR3/PRODH2 5 KEGG hsa05135 Yersinia infection 12/622 137/8135 0.3551 0.9992 0.9992 BAIAP2/DOCK1/MAP2K2/ARHGEF1/RAC2/ACTG1/MAPK11/PKN1/GSK3B/ITGA5/MAP2K3/RAC3 12 KEGG hsa05207 Chemical carcinogenesis - receptor activation 18/622 212/8135 0.3561 0.9992 0.9992 MAP2K2/FGF20/CHRNA4/DLL3/EPHX1/UGT2B7/RXRB/AR/CACNA1B/EGF/CACNA1S/EPHX3/JAK2/UGT2A3/RXRG/FGF9/UGT2B15/CREB3L2 18 KEGG hsa04512 ECM-receptor interaction 8/622 88/8135 0.3589 0.9992 0.9992 HSPG2/COL4A1/ITGA3/TNC/LAMA5/TNR/ITGA5/LAMC2 8 KEGG hsa04971 Gastric acid secretion 7/622 76/8135 0.3618 0.9992 0.9992 KCNK10/ACTG1/SLC4A2/ITPR3/CAMK2B/KCNJ15/ITPR2 7 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 8/622 89/8135 0.3708 0.9992 0.9992 MAP2K2/PPP3CA/EGF/MAPK11/JAK2/MAP2K3/IFNGR1/TICAM2 8 KEGG hsa00450 Selenocompound metabolism 2/622 17/8135 0.3774 0.9992 0.9992 MTR/TXNRD2 2 KEGG hsa00910 Nitrogen metabolism 2/622 17/8135 0.3774 0.9992 0.9992 CA6/CA5B 2 KEGG hsa05320 Autoimmune thyroid disease 5/622 53/8135 0.3817 0.9992 0.9992 IFNA17/IFNA4/HLA-E/CD80/IFNA6 5 KEGG hsa03440 Homologous recombination 4/622 41/8135 0.3841 0.9992 0.9992 BRCA1/NBN/RPA4/BABAM2 4 KEGG hsa04392 Hippo signaling pathway - multiple species 3/622 29/8135 0.3842 0.9992 0.9992 RASSF4/RASSF6/TEAD2 3 KEGG hsa04744 Phototransduction 3/622 29/8135 0.3842 0.9992 0.9992 GUCY2F/PDE6A/CNGB1 3 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 7/622 78/8135 0.3875 0.9992 0.9992 HSD11B1L/EPHX1/UGT2B7/CYP2D7/ADH4/UGT2A3/UGT2B15 7 KEGG hsa04721 Synaptic vesicle cycle 7/622 78/8135 0.3875 0.9992 0.9992 SNAP25/SYT1/CACNA1B/NAPA/CPLX1/DNM1/STX1A 7 KEGG hsa04380 Osteoclast differentiation 11/622 128/8135 0.3889 0.9992 0.9992 FCGR2C/PPP3CA/OSCAR/FCGR2B/CTSK/LILRB3/MAPK11/LILRA2/LILRB2/IFNGR1/LILRA6 11 KEGG hsa04022 cGMP-PKG signaling pathway 14/622 167/8135 0.4001 0.9992 0.9992 MAP2K2/PPP3CA/PIK3R5/INSR/KNG1/GATA4/CACNA1S/ITPR3/ATP2A3/KCNMB2/CNGB1/GNA11/ITPR2/CREB3L2 14 KEGG hsa04625 C-type lectin receptor signaling pathway 9/622 104/8135 0.4003 0.9992 0.9992 CLEC6A/PPP3CA/MAPK11/FCER1G/CLEC4D/ITPR3/CD209/IRF1/ITPR2 9 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 7/622 79/8135 0.4003 0.9992 0.9992 MAP2K2/EGF/GSK3B/SHC3/JAK2/BRAF/IGF1R 7 KEGG hsa00053 Ascorbate and aldarate metabolism 3/622 30/8135 0.4055 0.9992 0.9992 UGT2B7/UGT2A3/UGT2B15 3 KEGG hsa04068 FoxO signaling pathway 11/622 131/8135 0.4189 0.9992 0.9992 MAP2K2/INSR/EGF/SGK2/MAPK11/SMAD4/PCK2/PRMT1/BRAF/FBXO32/IGF1R 11 KEGG hsa04664 Fc epsilon RI signaling pathway 6/622 68/8135 0.4204 0.9992 0.9992 MAP2K2/RAC2/MAPK11/FCER1G/MAP2K3/RAC3 6 KEGG hsa04390 Hippo signaling pathway 13/622 157/8135 0.4244 0.9992 0.9992 WNT2B/PATJ/PPP2R2D/GDF7/ACTG1/BMP4/SMAD4/AXIN1/GSK3B/RASSF6/SMAD2/TEAD2/GDF5 13 KEGG hsa04024 cAMP signaling pathway 18/622 221/8135 0.4254 0.9992 0.9992 HTR1F/GPHA2/EDN1/GRIA1/MAP2K2/CRHR1/CNGA4/RAC2/GRIA3/CACNA1S/HTR6/BRAF/ATP2A3/CNGB1/CAMK2B/RAC3/GRIN3A/CREB3L2 18 KEGG hsa00410 beta-Alanine metabolism 3/622 31/8135 0.4265 0.9992 0.9992 CNDP2/ACADS/DPYD 3 KEGG hsa04920 Adipocytokine signaling pathway 6/622 69/8135 0.4343 0.9992 0.9992 TNFRSF1B/LEP/RXRB/JAK2/RXRG/PCK2 6 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 6/622 69/8135 0.4343 0.9992 0.9992 HSD11B1L/EPHX1/NAT2/UGT2B7/UGT2A3/UGT2B15 6 KEGG hsa04152 AMPK signaling pathway 10/622 120/8135 0.4366 0.9992 0.9992 PPP2R5D/PPP2R2D/LEP/INSR/PPP2R5A/ACACA/PCK2/RAB11B/CREB3L2/IGF1R 10 KEGG hsa04621 NOD-like receptor signaling pathway 15/622 184/8135 0.4371 0.9992 0.9992 RBCK1/IFNA17/IFNA4/CCL5/NLRP12/DEFA5/MAPK11/CASR/PKN1/ITPR3/SHARPIN/ANTXR2/IFNA6/TRIP6/ITPR2 15 KEGG hsa04962 Vasopressin-regulated water reabsorption 4/622 44/8135 0.4371 0.9992 0.9992 RAB5C/DYNC2LI1/RAB11B/CREB3L2 4 KEGG hsa04659 Th17 cell differentiation 9/622 108/8135 0.4449 0.9992 0.9992 PPP3CA/RXRB/IL21/MAPK11/SMAD4/SMAD2/JAK2/RXRG/IFNGR1 9 KEGG hsa00640 Propanoate metabolism 3/622 32/8135 0.4472 0.9992 0.9992 LDHAL6A/ACADS/ACACA 3 KEGG hsa04136 Autophagy - other 3/622 32/8135 0.4472 0.9992 0.9992 ATG13/MLST8/ATG7 3 KEGG hsa04917 Prolactin signaling pathway 6/622 70/8135 0.4482 0.9992 0.9992 MAP2K2/MAPK11/GSK3B/SHC3/JAK2/IRF1 6 KEGG hsa05230 Central carbon metabolism in cancer 6/622 70/8135 0.4482 0.9992 0.9992 MAP2K2/KIT/LDHAL6A/SIRT3/FGFR1/SIRT6 6 KEGG hsa05414 Dilated cardiomyopathy 8/622 96/8135 0.454 0.9992 0.9992 TNNC1/ITGA3/ACTG1/CACNA1S/ITGA5/MYL2/ATP2A3/CACNB1 8 KEGG hsa04144 Endocytosis 20/622 251/8135 0.4577 0.9992 0.9992 EHD3/CYTH1/GRK6/EPS15/HLA-E/RAB5C/DNM1/SH3GL1/LDLRAP1/SMAD2/PSD4/ARFGEF2/WASHC1/TSG101/ACAP1/RAB11B/PSD3/CXCR1/VPS37A/IGF1R 20 KEGG hsa00240 Pyrimidine metabolism 5/622 58/8135 0.459 0.9992 0.9992 NT5C2/UCK1/ENTPD5/NT5DC4/DPYD 5 KEGG hsa00480 Glutathione metabolism 5/622 58/8135 0.459 0.9992 0.9992 GCLM/GPX3/PGD/CHAC1/GPX1 5 KEGG hsa05213 Endometrial cancer 5/622 58/8135 0.459 0.9992 0.9992 MAP2K2/EGF/AXIN1/GSK3B/BRAF 5 KEGG hsa00670 One carbon pool by folate 2/622 20/8135 0.4591 0.9992 0.9992 MTR/MTHFD2L 2 KEGG hsa04070 Phosphatidylinositol signaling system 8/622 97/8135 0.4658 0.9992 0.9992 DGKQ/CDIPT/ITPR3/CDS2/SYNJ2/DGKI/INPP5B/ITPR2 8 KEGG hsa00051 Fructose and mannose metabolism 3/622 33/8135 0.4677 0.9992 0.9992 GMPPB/TKFC/PMM1 3 KEGG hsa03410 Base excision repair 3/622 33/8135 0.4677 0.9992 0.9992 POLL/PARP3/NTHL1 3 KEGG hsa04210 Apoptosis 11/622 136/8135 0.469 0.9992 0.9992 MAP2K2/CASP7/CTSK/ACTG1/PARP3/ENDOG/ITPR3/CAPN1/CTSL/NGF/ITPR2 11 KEGG hsa04370 VEGF signaling pathway 5/622 59/8135 0.4742 0.9992 0.9992 MAP2K2/PPP3CA/RAC2/MAPK11/RAC3 5 KEGG hsa04012 ErbB signaling pathway 7/622 85/8135 0.4768 0.9992 0.9992 MAP2K2/EGF/GSK3B/SHC3/BRAF/BTC/CAMK2B 7 KEGG hsa05231 Choline metabolism in cancer 8/622 98/8135 0.4776 0.9992 0.9992 MAP2K2/DGKQ/SLC44A5/RAC2/EGF/RALGDS/RAC3/DGKI 8 KEGG hsa00770 Pantothenate and CoA biosynthesis 2/622 21/8135 0.4849 0.9992 0.9992 BCAT2/DPYD 2 KEGG hsa00040 Pentose and glucuronate interconversions 3/622 34/8135 0.4877 0.9992 0.9992 UGT2B7/UGT2A3/UGT2B15 3 KEGG hsa04668 TNF signaling pathway 9/622 112/8135 0.4892 0.9992 0.9992 EDN1/CCL5/CASP7/TNFRSF1B/MMP9/MAPK11/MAP2K3/IRF1/CREB3L2 9 KEGG hsa05416 Viral myocarditis 5/622 60/8135 0.4892 0.9992 0.9992 RAC2/ACTG1/HLA-E/CD80/RAC3 5 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 8/622 100/8135 0.5009 0.9992 0.9992 EDN1/COL4A1/MAPK11/SMAD4/SMAD2/JAK2/THBD/CDK4 8 KEGG hsa01240 Biosynthesis of cofactors 12/622 153/8135 0.5075 0.9992 0.9992 UGT2B7/GCLM/GMPPB/BCAT2/AK7/MTHFD2L/AK8/UGT2A3/ALPL/COQ6/UGT2B15/PMM1 12 KEGG hsa00340 Histidine metabolism 2/622 22/8135 0.5099 0.9992 0.9992 AOC1/CNDP2 2 KEGG hsa04724 Glutamatergic synapse 9/622 114/8135 0.5109 0.9992 0.9992 GRIA1/GRIK3/PPP3CA/GRM3/GRIA3/GNG7/ITPR3/GRIN3A/ITPR2 9 KEGG hsa04540 Gap junction 7/622 88/8135 0.5141 0.9992 0.9992 HTR2A/TUBB2B/MAP2K2/EGF/ITPR3/GNA11/ITPR2 7 KEGG hsa05152 Tuberculosis 14/622 180/8135 0.5143 0.9992 0.9992 FCGR2C/IFNA17/IFNA4/PPP3CA/FCGR2B/MAPK11/FCER1G/HSPA9/RAB5C/CD209/JAK2/IFNGR1/CAMK2B/IFNA6 14 KEGG hsa05168 Herpes simplex virus 1 infection 38/622 495/8135 0.5155 0.9992 0.9992 ZNF717/IFNA17/IFNA4/CCL5/ZNF282/ZNF44/ZNF284/ZNF763/ZFP37/ZNF19/ZNF805/ZNF875/ZFP14/ZNF573/ZNF3/HLA-E/ZNF620/ZNF230/ZNF658/ITGA5/ZNF813/ZNF534/JAK2/ZNF34/ZNF157/ZNF888/ZNF764/SP100/ZNF460/ZNF98/ZNF548/ZNF718/IFNGR1/ZNF234/IFNA6/ZNF768/ZNF175/ZNF556 38 KEGG hsa03320 PPAR signaling pathway 6/622 75/8135 0.5162 0.9992 0.9992 CYP8B1/RXRB/CYP27A1/RXRG/PCK2/PLIN1 6 KEGG hsa00565 Ether lipid metabolism 4/622 49/8135 0.5221 0.9992 0.9992 LPCAT4/UGT8/GDPD3/PLA2G2F 4 KEGG hsa05142 Chagas disease 8/622 102/8135 0.5239 0.9992 0.9992 CCL5/PPP2R2D/KNG1/MAPK11/SMAD2/C1QC/IFNGR1/GNA11 8 KEGG hsa04976 Bile secretion 7/622 89/8135 0.5264 0.9992 0.9992 EPHX1/UGT2B7/SLC4A2/UGT2A3/UGT2B15/SLC10A1/SCT 7 KEGG hsa04936 Alcoholic liver disease 11/622 142/8135 0.528 0.9992 0.9992 IFNA17/IFNA4/ADH4/MAPK11/IL17RC/GSK3B/ACACA/MAP2K3/C1QC/C5AR1/IFNA6 11 KEGG hsa05133 Pertussis 6/622 76/8135 0.5294 0.9992 0.9992 CASP7/MAPK11/ITGA5/C1QC/TICAM2/IRF1 6 KEGG hsa05220 Chronic myeloid leukemia 6/622 76/8135 0.5294 0.9992 0.9992 MAP2K2/CDK6/SMAD4/SHC3/CDK4/BRAF 6 KEGG hsa05217 Basal cell carcinoma 5/622 63/8135 0.5333 0.9992 0.9992 WNT2B/BMP4/AXIN1/GSK3B/SUFU 5 KEGG hsa00515 Mannose type O-glycan biosynthesis 2/622 23/8135 0.5342 0.9992 0.9992 CHST10/ST3GAL3 2 KEGG hsa03430 Mismatch repair 2/622 23/8135 0.5342 0.9992 0.9992 RFC2/RPA4 2 KEGG hsa04964 Proximal tubule bicarbonate reclamation 2/622 23/8135 0.5342 0.9992 0.9992 PCK2/SLC25A10 2 KEGG hsa04974 Protein digestion and absorption 8/622 103/8135 0.5352 0.9992 0.9992 CELA3A/COL4A1/KCNJ13/SLC36A2/SLC3A2/COL10A1/COL17A1/COL23A1 8 KEGG hsa04979 Cholesterol metabolism 4/622 50/8135 0.5384 0.9992 0.9992 LPA/CYP27A1/LDLRAP1/OSBPL5 4 KEGG hsa05160 Hepatitis C 12/622 157/8135 0.5445 0.9992 0.9992 IFNA17/IFNA4/MAP2K2/CDK6/PPP2R2D/EGF/GSK3B/CLDN8/CDK4/IFIT1B/BRAF/IFNA6 12 KEGG hsa00920 Sulfur metabolism 1/622 10/8135 0.5488 0.9992 0.9992 MPST 1 KEGG hsa04913 Ovarian steroidogenesis 4/622 51/8135 0.5544 0.9992 0.9992 INSR/HSD3B2/BMP15/IGF1R 4 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2/622 24/8135 0.5576 0.9992 0.9992 EXTL1/HS3ST1 2 KEGG hsa04977 Vitamin digestion and absorption 2/622 24/8135 0.5576 0.9992 0.9992 SLC19A3/SLC19A2 2 KEGG hsa04142 Lysosome 10/622 132/8135 0.5601 0.9992 0.9992 CTNS/CTSK/SMPD1/MCOLN1/AP4M1/AP1G1/DMXL2/CTSL/AP4E1/AP1M2 10 KEGG hsa04658 Th1 and Th2 cell differentiation 7/622 92/8135 0.5624 0.9992 0.9992 PPP3CA/DLL3/MAPK11/NOTCH1/RBPJL/JAK2/IFNGR1 7 KEGG hsa00600 Sphingolipid metabolism 4/622 52/8135 0.5701 0.9992 0.9992 SMPD1/CERS4/UGT8/SMPD2 4 KEGG hsa04970 Salivary secretion 7/622 93/8135 0.5741 0.9992 0.9992 RYR3/MUC5B/SLC4A2/PRB1/ITPR3/PRH1/ITPR2 7 KEGG hsa00983 Drug metabolism - other enzymes 6/622 80/8135 0.5808 0.9992 0.9992 NAT2/UGT2B7/UCK1/UGT2A3/UGT2B15/DPYD 6 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 1/622 11/8135 0.5834 0.9992 0.9992 COQ6 1 KEGG hsa05417 Lipid and atherosclerosis 16/622 215/8135 0.5835 0.9992 0.9992 IFNA17/IFNA4/CCL5/PPP3CA/ARHGEF1/CASP7/RXRB/MMP9/MAPK11/GSK3B/JAK2/RXRG/MAP2K3/CAMK2B/TICAM2/IFNA6 16 KEGG hsa04657 IL-17 signaling pathway 7/622 94/8135 0.5856 0.9992 0.9992 MUC5B/MMP9/MAPK11/CCL11/IL17RC/GSK3B/TRAF4 7 KEGG hsa00010 Glycolysis / Gluconeogenesis 5/622 67/8135 0.5892 0.9992 0.9992 ENO4/GALM/ADH4/LDHAL6A/PCK2 5 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 2/622 26/8135 0.6018 0.9992 0.9992 PIGC/DPM2 2 KEGG hsa04950 Maturity onset diabetes of the young 2/622 26/8135 0.6018 0.9992 0.9992 FOXA3/FOXA2 2 KEGG hsa05150 Staphylococcus aureus infection 7/622 96/8135 0.6083 0.9992 0.9992 DEFB1/FCGR2C/FCGR2B/DEFA5/C1QC/C5AR1/KRT24 7 KEGG hsa04014 Ras signaling pathway 17/622 232/8135 0.6101 0.9992 0.9992 MAP2K2/FGF20/RAC2/INSR/EGF/GNG7/RALGDS/RAB5C/KIT/SHC3/ANGPT2/FGF9/NGF/PLA2G2F/RAC3/FGFR1/IGF1R 17 KEGG hsa04714 Thermogenesis 17/622 232/8135 0.6101 0.9992 0.9992 SMARCD2/ACTG1/MAPK11/COX20/SMARCA4/ATP5MF/MAP2K3/CYC1/NDUFB10/MLST8/FGFR1/NDUFAF7/COX7A1/COX4I2/SIRT6/PLIN1/CREB3L2 17 KEGG hsa05020 Prion disease 20/622 273/8135 0.6142 0.9992 0.9992 RYR3/TUBB2B/CCL5/PPP3CA/RAC2/PSMC2/CACNA1B/MAPK11/CACNA1S/NOTCH1/GSK3B/ITPR3/C1QC/CYC1/NDUFB10/COX7A1/COX4I2/GRIN3A/ITPR2/CREB3L2 20 KEGG hsa04611 Platelet activation 9/622 124/8135 0.6145 0.9992 0.9992 P2RX1/ARHGEF1/PIK3R5/F2RL3/ACTG1/MAPK11/FCER1G/ITPR3/ITPR2 9 KEGG hsa04924 Renin secretion 5/622 69/8135 0.6158 0.9992 0.9992 EDN1/PPP3CA/CACNA1S/ITPR3/ITPR2 5 KEGG hsa04216 Ferroptosis 3/622 41/8135 0.6166 0.9992 0.9992 GCLM/SLC3A2/ATG7 3 KEGG hsa00062 Fatty acid elongation 2/622 27/8135 0.6227 0.9992 0.9992 ELOVL5/TECR 2 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 2/622 27/8135 0.6227 0.9992 0.9992 ELOVL5/TECR 2 KEGG hsa04371 Apelin signaling pathway 10/622 139/8135 0.6269 0.9992 0.9992 RYR3/MAP2K2/PIK3R5/GNG7/SMAD4/ITPR3/SMAD2/MYL2/PLIN1/ITPR2 10 KEGG hsa00564 Glycerophospholipid metabolism 7/622 98/8135 0.6303 0.9992 0.9992 DGKQ/PNPLA6/LPCAT4/CDIPT/CDS2/PLA2G2F/DGKI 7 KEGG hsa00380 Tryptophan metabolism 3/622 42/8135 0.6331 0.9992 0.9992 AOC1/AOX1/IL4I1 3 KEGG hsa05332 Graft-versus-host disease 3/622 42/8135 0.6331 0.9992 0.9992 KIR3DL3/HLA-E/CD80 3 KEGG hsa04921 Oxytocin signaling pathway 11/622 154/8135 0.6383 0.9992 0.9992 RYR3/MAP2K2/PPP3CA/PIK3R5/KCNJ18/ACTG1/CACNA1S/ITPR3/CAMK2B/CACNB1/ITPR2 11 KEGG hsa04610 Complement and coagulation cascades 6/622 85/8135 0.6407 0.9992 0.9992 F2RL3/KNG1/F7/THBD/C1QC/C5AR1 6 KEGG hsa03450 Non-homologous end-joining 1/622 13/8135 0.6447 0.9992 0.9992 POLL 1 KEGG hsa00860 Porphyrin metabolism 3/622 43/8135 0.6491 0.9992 0.9992 UGT2B7/UGT2A3/UGT2B15 3 KEGG hsa05130 Pathogenic Escherichia coli infection 14/622 197/8135 0.653 0.9992 0.9992 BAIAP2/MYH11/TUBB2B/ARHGEF1/CASP7/CYTH1/MYH14/RPS3/ACTG1/MYO1C/MAPK11/MYO1G/MYO1H/CLDN8 14 KEGG hsa04150 mTOR signaling pathway 11/622 156/8135 0.6553 0.9992 0.9992 MAP2K2/WNT2B/RICTOR/INSR/GSK3B/SLC3A2/BRAF/CLIP1/MLST8/TBC1D7/IGF1R 11 KEGG hsa01200 Carbon metabolism 8/622 115/8135 0.6616 0.9992 0.9992 ENO4/PGD/GPT/ACO1/ACADS/TKFC/OGDH/IDH3G 8 KEGG hsa04926 Relaxin signaling pathway 9/622 129/8135 0.6619 0.9992 0.9992 EDN1/MAP2K2/COL4A1/MMP9/GNG7/MAPK11/SHC3/SMAD2/CREB3L2 9 KEGG hsa04916 Melanogenesis 7/622 101/8135 0.6619 0.9992 0.9992 EDN1/MAP2K2/WNT2B/KIT/GSK3B/CAMK2B/CREB3L2 7 KEGG hsa04115 p53 signaling pathway 5/622 73/8135 0.6657 0.9992 0.9992 CDK6/CDK4/COP1/AIFM2/SESN1 5 KEGG hsa04972 Pancreatic secretion 7/622 102/8135 0.6721 0.9992 0.9992 CELA3A/SLC4A2/ITPR3/ATP2A3/PLA2G2F/SCT/ITPR2 7 KEGG hsa03022 Basal transcription factors 3/622 45/8135 0.6796 0.9992 0.9992 TAF1L/TAF12/GTF2H4 3 KEGG hsa04217 Necroptosis 11/622 159/8135 0.68 0.9992 0.9992 RBCK1/IFNA17/IFNA4/SMPD1/JAK2/CAPN1/SHARPIN/IFNGR1/CAMK2B/TICAM2/IFNA6 11 KEGG hsa04211 Longevity regulating pathway 6/622 89/8135 0.6847 0.9992 0.9992 EHMT2/ATG13/INSR/CREB3L2/IGF1R/SESN1 6 KEGG hsa04918 Thyroid hormone synthesis 5/622 75/8135 0.6891 0.9992 0.9992 GPX3/ITPR3/ITPR2/CREB3L2/GPX1 5 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 34/622 476/8135 0.6908 0.9992 0.9992 RYR3/GRIA1/TUBB2B/MAP2K2/WNT2B/DNAH9/PPP3CA/CASP7/ATG13/TNFRSF1B/PSMC2/GRIA3/DNAH2/CACNA1B/FRAT1/MAPK11/GPX3/CACNA1S/AXIN1/GSK3B/ITPR3/CAPN1/MAP2K3/BRAF/DNAH3/CYC1/ATP2A3/NDUFB10/CAMK2B/STX1A/COX7A1/COX4I2/ITPR2/GPX1 34 KEGG hsa04930 Type II diabetes mellitus 3/622 46/8135 0.6942 0.9992 0.9992 INSR/CACNA1B/KCNJ11 3 KEGG hsa00561 Glycerolipid metabolism 4/622 61/8135 0.6962 0.9992 0.9992 DGKQ/MOGAT1/TKFC/DGKI 4 KEGG hsa05415 Diabetic cardiomyopathy 14/622 203/8135 0.6966 0.9992 0.9992 RAC2/INSR/MMP9/MAPK11/GSK3B/PTPA/SMAD2/CYC1/ATP2A3/NDUFB10/CAMK2B/COX7A1/COX4I2/GFPT1 14 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/622 15/8135 0.697 0.9992 0.9992 B3GALT5 1 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 1/622 15/8135 0.697 0.9992 0.9992 ST6GALNAC5 1 KEGG hsa04710 Circadian rhythm 2/622 31/8135 0.6976 0.9992 0.9992 ARNTL/NR1D1 2 KEGG hsa05310 Asthma 2/622 31/8135 0.6976 0.9992 0.9992 FCER1G/CCL11 2 KEGG hsa04723 Retrograde endocannabinoid signaling 10/622 148/8135 0.7044 0.9992 0.9992 GRIA1/GABRB1/GRIA3/CACNA1B/GNG7/MAPK11/CACNA1S/ITPR3/NDUFB10/ITPR2 10 KEGG hsa05100 Bacterial invasion of epithelial cells 5/622 77/8135 0.7113 0.9992 0.9992 DOCK1/ACTG1/DNM1/SHC3/ITGA5 5 KEGG hsa04215 Apoptosis - multiple species 2/622 32/8135 0.7143 0.9992 0.9992 CASP7/BIRC6 2 KEGG hsa00360 Phenylalanine metabolism 1/622 16/8135 0.7203 0.9992 0.9992 IL4I1 1 KEGG hsa00310 Lysine degradation 4/622 63/8135 0.7203 0.9992 0.9992 EHMT2/KMT2C/KMT5C/PRDM6 4 KEGG hsa04623 Cytosolic DNA-sensing pathway 4/622 63/8135 0.7203 0.9992 0.9992 IFNA17/IFNA4/CCL5/IFNA6 4 KEGG hsa03018 RNA degradation 5/622 79/8135 0.7323 0.9992 0.9992 ENO4/HSPA9/SKIV2L/TTC37/EXOSC5 5 KEGG hsa05030 Cocaine addiction 3/622 49/8135 0.7347 0.9992 0.9992 GRM3/GRIN3A/CREB3L2 3 KEGG hsa04145 Phagosome 10/622 152/8135 0.7354 0.9992 0.9992 FCGR2C/TUBB2B/FCGR2B/ACTG1/HLA-E/RAB5C/COLEC12/CD209/ITGA5/CTSL 10 KEGG hsa05321 Inflammatory bowel disease 4/622 65/8135 0.7429 0.9992 0.9992 IL18RAP/IL21/SMAD2/IFNGR1 4 KEGG hsa05418 Fluid shear stress and atherosclerosis 9/622 139/8135 0.7457 0.9992 0.9992 EDN1/RAC2/MMP9/ACTG1/BMP4/MAPK11/THBD/CTSL/RAC3 9 KEGG hsa05144 Malaria 3/622 50/8135 0.7472 0.9992 0.9992 GYPA/GYPB/ACKR1 3 KEGG hsa04530 Tight junction 11/622 169/8135 0.7544 0.9992 0.9992 MAGI1/MYH11/MYH14/PATJ/PPP2R2D/ACTG1/TJP3/GATA4/CLDN8/MYL2/CDK4 11 KEGG hsa03015 mRNA surveillance pathway 6/622 97/8135 0.7617 0.9992 0.9992 PPP2R5D/PPP2R2D/RNGTT/PPP2R5A/SMG6/NCBP2L 6 KEGG hsa04713 Circadian entrainment 6/622 97/8135 0.7617 0.9992 0.9992 RYR3/GRIA1/GRIA3/GNG7/ITPR3/CAMK2B 6 KEGG hsa05145 Toxoplasmosis 7/622 112/8135 0.763 0.9992 0.9992 PIK3R5/LAMA5/MAPK11/JAK2/MAP2K3/IFNGR1/LAMC2 7 KEGG hsa05221 Acute myeloid leukemia 4/622 67/8135 0.7642 0.9992 0.9992 MAP2K2/RUNX1T1/KIT/BRAF 4 KEGG hsa05164 Influenza A 11/622 171/8135 0.7677 0.9992 0.9992 IFNA17/IFNA4/CCL5/MAP2K2/CDK6/ACTG1/JAK2/CDK4/IFNGR1/IFNA6/RAB11B 11 KEGG hsa00500 Starch and sucrose metabolism 2/622 36/8135 0.7735 0.9992 0.9992 GYG1/AGL 2 KEGG hsa04670 Leukocyte transendothelial migration 7/622 114/8135 0.7788 0.9992 0.9992 RAC2/MMP9/ACTG1/MAPK11/CLDN8/MYL2/CXCL12 7 KEGG hsa05131 Shigellosis 16/622 247/8135 0.7919 0.9992 0.9992 RBCK1/CCL5/DOCK1/CYTH1/ACTG1/MAPK11/GSK3B/ITPR3/CAPNS1/U2AF1L4/ITGA5/MYL2/CAPN1/SHARPIN/UBE2D1/ITPR2 16 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/622 20/8135 0.7966 0.9992 0.9992 CHST13 1 KEGG hsa04742 Taste transduction 5/622 86/8135 0.7972 0.9992 0.9992 HTR1F/TAS2R30/TAS2R19/ITPR3/ASIC2 5 KEGG hsa05330 Allograft rejection 2/622 38/8135 0.7989 0.9992 0.9992 HLA-E/CD80 2 KEGG hsa05146 Amoebiasis 6/622 102/8135 0.8023 0.9992 0.9992 SERPINB13/COL4A1/LAMA5/RAB5C/LAMC2/GNA11 6 KEGG hsa04630 JAK-STAT signaling pathway 10/622 162/8135 0.803 0.9992 0.9992 IFNA17/IFNA4/LEP/AOX1/EGF/IL21/JAK2/IL20RA/IFNGR1/IFNA6 10 KEGG hsa00513 Various types of N-glycan biosynthesis 2/622 39/8135 0.8106 0.9992 0.9992 ST3GAL3/B4GALNT3 2 KEGG hsa04340 Hedgehog signaling pathway 3/622 56/8135 0.8127 0.9992 0.9992 DISP1/GSK3B/SUFU 3 KEGG hsa00562 Inositol phosphate metabolism 4/622 73/8135 0.8197 0.9992 0.9992 INPP5J/CDIPT/SYNJ2/INPP5B 4 KEGG hsa04727 GABAergic synapse 5/622 89/8135 0.8209 0.9992 0.9992 GABRB1/CACNA1B/GNG7/CACNA1S/SLC12A5 5 KEGG hsa04910 Insulin signaling pathway 8/622 137/8135 0.8324 0.9992 0.9992 PRKAR2A/MAP2K2/INSR/GSK3B/SHC3/ACACA/PCK2/BRAF 8 KEGG hsa05032 Morphine addiction 5/622 91/8135 0.8354 0.9992 0.9992 PDE8B/GABRB1/GRK6/CACNA1B/GNG7 5 KEGG hsa03060 Protein export 1/622 23/8135 0.8399 0.9992 0.9992 SEC62 1 KEGG hsa04614 Renin-angiotensin system 1/622 23/8135 0.8399 0.9992 0.9992 PREP 1 KEGG hsa03013 Nucleocytoplasmic transport 6/622 108/8135 0.8436 0.9992 0.9992 XPO4/NUP188/AAAS/NUP62/NUP58/NCBP2L 6 KEGG hsa04931 Insulin resistance 6/622 108/8135 0.8436 0.9992 0.9992 INSR/GSK3B/PTPA/PCK2/GFPT1/CREB3L2 6 KEGG hsa05162 Measles 8/622 139/8135 0.8439 0.9992 0.9992 IFNA17/IFNA4/CDK6/FCGR2B/GSK3B/CD209/CDK4/IFNA6 8 KEGG hsa04932 Non-alcoholic fatty liver disease 9/622 155/8135 0.8479 0.9992 0.9992 CASP7/LEP/INSR/MAPK11/GSK3B/CYC1/NDUFB10/COX7A1/COX4I2 9 KEGG hsa05323 Rheumatoid arthritis 5/622 93/8135 0.849 0.9992 0.9992 CCL5/CTSK/CD80/CTSL/CXCL12 5 KEGG hsa05140 Leishmaniasis 4/622 77/8135 0.8504 0.9992 0.9992 FCGR2C/MAPK11/JAK2/IFNGR1 4 KEGG hsa00071 Fatty acid degradation 2/622 43/8135 0.8516 0.9992 0.9992 ADH4/ACADS 2 KEGG hsa04940 Type I diabetes mellitus 2/622 43/8135 0.8516 0.9992 0.9992 HLA-E/CD80 2 KEGG hsa00590 Arachidonic acid metabolism 3/622 61/8135 0.8557 0.9992 0.9992 GPX3/PLA2G2F/GPX1 3 KEGG hsa04120 Ubiquitin mediated proteolysis 8/622 142/8135 0.8599 0.9992 0.9992 ANAPC1/VHL/DET1/BRCA1/FBXW8/COP1/BIRC6/UBE2D1 8 KEGG hsa04213 Longevity regulating pathway - multiple species 3/622 62/8135 0.8632 0.9992 0.9992 INSR/FOXA2/IGF1R 3 KEGG hsa00592 alpha-Linolenic acid metabolism 1/622 25/8135 0.8635 0.9992 0.9992 PLA2G2F 1 KEGG hsa02010 ABC transporters 2/622 45/8135 0.8689 0.9992 0.9992 DEFB1/ABCA9 2 KEGG hsa00790 Folate biosynthesis 1/622 26/8135 0.874 0.9992 0.9992 ALPL 1 KEGG hsa04640 Hematopoietic cell lineage 5/622 99/8135 0.8842 0.9992 0.9992 ITGA3/FCER2/GYPA/KIT/ITGA5 5 KEGG hsa00514 Other types of O-glycan biosynthesis 2/622 47/8135 0.8843 0.9992 0.9992 ST3GAL3/GALNT17 2 KEGG hsa04514 Cell adhesion molecules 8/622 149/8135 0.8921 0.9992 0.9992 NFASC/HLA-E/CD80/NLGN1/TIGIT/CADM3/CLDN8/NEO1 8 KEGG hsa04672 Intestinal immune network for IgA production 2/622 49/8135 0.8981 0.9992 0.9992 CD80/CXCL12 2 KEGG hsa00591 Linoleic acid metabolism 1/622 29/8135 0.9008 0.9992 0.9992 PLA2G2F 1 KEGG hsa05014 Amyotrophic lateral sclerosis 22/622 364/8135 0.9027 0.9992 0.9992 GRIA1/TUBB2B/DNAH9/PPP3CA/ATG13/TNFRSF1B/PSMC2/DNAH2/ACTG1/MAPK11/GPX3/ITPR3/NUP188/MAP2K3/DNAH3/CYC1/NUP62/NUP58/NDUFB10/COX7A1/COX4I2/GPX1 22 KEGG hsa00510 N-Glycan biosynthesis 2/622 50/8135 0.9044 0.9992 0.9992 DPM1/DPM2 2 KEGG hsa05211 Renal cell carcinoma 3/622 69/8135 0.9067 0.9992 0.9992 MAP2K2/VHL/BRAF 3 KEGG hsa04660 T cell receptor signaling pathway 5/622 104/8135 0.908 0.9992 0.9992 MAP2K2/PPP3CA/MAPK11/GSK3B/CDK4 5 KEGG hsa00030 Pentose phosphate pathway 1/622 30/8135 0.9084 0.9992 0.9992 PGD 1 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 1/622 30/8135 0.9084 0.9992 0.9992 ACO1 1 KEGG hsa04915 Estrogen signaling pathway 7/622 138/8135 0.9117 0.9992 0.9992 MAP2K2/MMP9/ITPR3/SHC3/KRT24/ITPR2/CREB3L2 7 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 3/622 70/8135 0.9118 0.9992 0.9992 CCL5/MAPK11/CXCR1 3 KEGG hsa05169 Epstein-Barr virus infection 11/622 202/8135 0.9132 0.9992 0.9992 IFNA17/IFNA4/CDK6/PSMC2/FCER2/MAPK11/HLA-E/RBPJL/CDK4/MAP2K3/IFNA6 11 KEGG hsa05132 Salmonella infection 14/622 249/8135 0.9152 0.9992 0.9992 TUBB2B/MAP2K2/CASP7/CYTH1/RPS3/ACTG1/MAPK11/PKN1/RAB5C/PLEKHM2/DYNC2LI1/MYL2/MAP2K3/FLNC 14 KEGG hsa05010 Alzheimer disease 23/622 384/8135 0.9153 0.9992 0.9992 RYR3/TUBB2B/MAP2K2/WNT2B/PPP3CA/CASP7/ATG13/PSMC2/INSR/FRAT1/CACNA1S/AXIN1/GSK3B/ITPR3/CAPN1/SLC39A3/BRAF/CYC1/ATP2A3/NDUFB10/COX7A1/COX4I2/ITPR2 23 KEGG hsa00052 Galactose metabolism 1/622 31/8135 0.9155 0.9992 0.9992 GALM 1 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/622 53/8135 0.9211 0.9992 0.9992 DNM1/PTH1R 2 KEGG hsa03010 Ribosome 8/622 158/8135 0.9243 0.9992 0.9992 MRPL3/RPS3/MRPL12/MRPL19/RPS28/RPS13/RPL13A/MRPL28 8 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 12/622 223/8135 0.9281 0.9992 0.9992 MAP2K2/PRKD2/SLC26A1/EPHX1/EGF/MAPK11/EPHX3/BRAF/CYC1/NDUFB10/COX7A1/COX4I2 12 KEGG hsa04923 Regulation of lipolysis in adipocytes 2/622 56/8135 0.9351 0.9992 0.9992 INSR/PLIN1 2 KEGG hsa04740 Olfactory transduction 26/622 440/8135 0.9377 0.9992 0.9992 OR4C46/OR1C1/OR8K3/OR4D2/OR56A3/CNGA4/OR4C6/OR4P4/OR13D1/OR2T12/OR4N2/OR5F1/GNG7/OR6V1/OR10H5/OR5H6/OR52W1/OR5C1/OR6M1/OR52E8/OR4N4/CNGB1/CAMK2B/OR4A16/OR2T11/OR5H1 26 KEGG hsa05016 Huntington disease 17/622 306/8135 0.9403 0.9992 0.9992 GRIA1/TUBB2B/DNAH9/ATG13/PSMC2/GRIA3/DNAH2/CACNA1B/GPX3/DNAH3/CYC1/NDUFB10/STX1A/COX7A1/COX4I2/CREB3L2/GPX1 17 KEGG hsa00512 Mucin type O-glycan biosynthesis 1/622 36/8135 0.9433 0.9992 0.9992 GALNT17 1 KEGG hsa04612 Antigen processing and presentation 3/622 78/8135 0.9441 0.9992 0.9992 KIR3DL3/HLA-E/CTSL 3 KEGG hsa04666 Fc gamma R-mediated phagocytosis 4/622 97/8135 0.9455 0.9992 0.9992 DOCK1/HCK/FCGR2B/RAC2 4 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 1/622 37/8135 0.9477 0.9992 0.9992 INSR 1 KEGG hsa05143 African trypanosomiasis 1/622 37/8135 0.9477 0.9992 0.9992 KNG1 1 KEGG hsa04146 Peroxisome 3/622 82/8135 0.9558 0.9992 0.9992 ACOT8/ECH1/HMGCL 3 KEGG hsa04064 NF-kappa B signaling pathway 4/622 104/8135 0.9626 0.9992 0.9992 CCL21/EDA/CXCL12/TICAM2 4 KEGG hsa04140 Autophagy - animal 6/622 141/8135 0.964 0.9992 0.9992 MAP2K2/ATG13/CTSL/MLST8/ATG7/IGF1R 6 KEGG hsa05202 Transcriptional misregulation in cancer 9/622 193/8135 0.9647 0.9992 0.9992 RUNX1T1/SSX2B/GRIA3/RXRB/MMP9/DEFA5/RXRG/SS18L1/IGF1R 9 KEGG hsa04975 Fat digestion and absorption 1/622 43/8135 0.9676 0.9992 0.9992 PLA2G2F 1 KEGG hsa03040 Spliceosome 6/622 147/8135 0.9731 0.9992 0.9992 PPIE/U2AF1L4/SF3B4/SNRPB/NCBP2L/PUF60 6 KEGG hsa03050 Proteasome 1/622 46/8135 0.9745 0.9992 0.9992 PSMC2 1 KEGG hsa05203 Viral carcinogenesis 9/622 204/8135 0.9781 0.9992 0.9992 CDK6/HLA-E/MAD1L1/RBPJL/CDK4/SP100/DDX3X/GTF2H4/CREB3L2 9 KEGG hsa05166 Human T-cell leukemia virus 1 infection 10/622 222/8135 0.9789 0.9992 0.9992 MAP2K2/PPP3CA/ANAPC1/HLA-E/MAD1L1/SMAD4/PTTG2/SMAD2/CDK4/CREB3L2 10 KEGG hsa01524 Platinum drug resistance 2/622 73/8135 0.9792 0.9992 0.9992 BRCA1/REV3L 2 KEGG hsa00190 Oxidative phosphorylation 5/622 134/8135 0.9796 0.9992 0.9992 ATP5MF/CYC1/NDUFB10/COX7A1/COX4I2 5 KEGG hsa04141 Protein processing in endoplasmic reticulum 7/622 171/8135 0.98 0.9992 0.9992 YOD1/SEC62/DNAJB2/WFS1/CAPN1/UBE2D1/P4HB 7 KEGG hsa05110 Vibrio cholerae infection 1/622 50/8135 0.9815 0.9992 0.9992 ACTG1 1 KEGG hsa05171 Coronavirus disease - COVID-19 10/622 232/8135 0.9864 0.9992 0.9992 IFNA17/IFNA4/RPS3/MAPK11/RPS28/RPS13/RPL13A/C1QC/C5AR1/IFNA6 10 KEGG hsa05134 Legionellosis 1/622 57/8135 0.9894 0.9992 0.9992 CASP7 1 KEGG hsa03008 Ribosome biogenesis in eukaryotes 3/622 109/8135 0.9917 0.9992 0.9992 RMRP/DROSHA/LSG1 3 KEGG hsa04978 Mineral absorption 1/622 60/8135 0.9917 0.9992 0.9992 ATOX1 1 KEGG hsa05012 Parkinson disease 11/622 266/8135 0.9935 0.9992 0.9992 RYR3/TUBB2B/PSMC2/ITPR3/SLC39A3/CYC1/NDUFB10/CAMK2B/COX7A1/COX4I2/ITPR2 11 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/622 66/8135 0.9949 0.9992 0.9992 FARSA 1 KEGG hsa04613 Neutrophil extracellular trap formation 6/622 190/8135 0.9973 0.9992 0.9992 MAP2K2/RAC2/ACTG1/MAPK11/C5AR1/ATG7 6 KEGG hsa05322 Systemic lupus erythematosus 3/622 136/8135 0.9986 0.9992 0.9992 CD80/SNRPB/C1QC 3 KEGG hsa05034 Alcoholism 5/622 187/8135 0.999 0.9992 0.9992 GNG7/SHC3/BRAF/GRIN3A/CREB3L2 5 KEGG hsa05206 MicroRNAs in cancer 11/622 310/8135 0.9992 0.9992 0.9992 MAP2K2/CDK6/DNMT1/TNC/MMP9/IGF2BP1/TNR/NOTCH1/BRCA1/ITGA5/STMN1 11