ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04657	IL-17 signaling pathway	26/854	94/8135	2.429e-06	0.0004659	0.0004119	CXCL8/CCL2/CSF3/CCL7/CXCL1/USP25/CXCL3/MMP1/HSP90B1/CCL20/NFKBIA/CXCL2/CXCL6/IL17C/TRAF5/TRAF2/MMP3/CXCL5/MAPK14/SRSF1/NFKB1/MAPK11/TRAF3IP2/PTGS2/RELA/MAPK7	26
KEGG	hsa04668	TNF signaling pathway	29/854	112/8135	2.815e-06	0.0004659	0.0004119	CCL2/CXCL1/CXCL3/ATF4/CCL20/NFKBIA/CXCL2/CXCL6/NOD2/BCL3/TRAF5/TRAF2/BIRC3/CFLAR/RIPK3/MMP3/BIRC2/DNM1L/MAP2K3/CXCL5/MAPK14/ICAM1/NFKB1/MAP2K4/MAPK11/IL18R1/CREB3L2/PTGS2/RELA	29
KEGG	hsa04141	Protein processing in endoplasmic reticulum	34/854	171/8135	0.000168	0.01498	0.01324	SEC13/SEC23A/SSR1/ATF4/SSR3/PREB/HSP90B1/HYOU1/P4HB/PDIA6/TRAF2/STT3B/RRBP1/TXNDC5/SEC23B/ERN1/LMAN1/SEC61A1/ATF6/UGGT1/SVIP/CKAP4/PDIA3/BAG2/SEC61G/STT3A/CALR/UBXN1/PLAA/CANX/UBXN8/BAG1/RPN1/SEC24D	34
KEGG	hsa00240	Pyrimidine metabolism	16/854	58/8135	0.000216	0.01498	0.01324	NME1-NME2/NME2/CTPS1/NT5C3A/ENTPD1/DUT/CMPK1/NME1/NME4/CTPS2/CMPK2/CAD/CANT1/RRM1/ENTPD6/TYMP	16
KEGG	hsa01240	Biosynthesis of cofactors	31/854	153/8135	0.0002263	0.01498	0.01324	NME1-NME2/NME2/HMBS/PDXK/MTHFD1/GCH1/AKR1A1/CPOX/CTPS1/DHFR2/PTS/GMPPA/COASY/CMPK1/PSAT1/NME1/ALDH3A2/MAT2A/LIAS/NME4/NFS1/CTPS2/CMPK2/CAD/MTHFD2/BCAT1/GCLC/SHMT2/COQ7/GMPPB/TPK1	31
KEGG	hsa04621	NOD-like receptor signaling pathway	35/854	184/8135	0.0003317	0.0183	0.01618	CXCL8/CCL2/CXCL1/CXCL3/NAMPT/MCU/TYK2/MYD88/NFKBIA/IFNAR2/CXCL2/NOD2/JAK1/TRAF5/TRAF2/ANTXR2/BIRC3/PLCB1/RIPK3/RIPK2/BIRC2/NLRX1/DNM1L/MAPK14/VDAC2/ATG16L1/CYBA/RNF31/TANK/IRF7/NFKB1/ATG5/MAPK11/VDAC1/RELA	35
KEGG	hsa00513	Various types of N-glycan biosynthesis	12/854	39/8135	0.0004421	0.02091	0.01848	ALG1/B4GALT2/ALG3/ALG14/STT3B/B4GALT3/MGAT2/MGAT4B/CHST9/ALG9/STT3A/RPN1	12
KEGG	hsa04622	RIG-I-like receptor signaling pathway	17/854	70/8135	0.0007135	0.02788	0.02465	CXCL8/NFKBIA/IL12A/TRAF2/IFIH1/NLRX1/OTUD5/MAPK14/DHX58/TRIM25/TANK/IRF7/NFKB1/ATG5/MAPK11/AZI2/RELA	17
KEGG	hsa05164	Influenza A	32/854	171/8135	0.0007883	0.02788	0.02465	CXCL8/CCL2/IFNGR2/NXF1/TNFRSF10B/TYK2/MYD88/BCL2L2-PABPN1/PABPN1/NFKBIA/IFNAR2/IL12A/JAK1/RSAD2/PML/IFIH1/MX1/NLRX1/HNRNPUL1/RAB11B/TLR3/ACTG1/ICAM1/TRIM25/IRF7/NFKB1/ACTB/VDAC1/XPO1/BID/RELA/NXF3	32
KEGG	hsa05417	Lipid and atherosclerosis	38/854	215/8135	0.0008423	0.02788	0.02465	CXCL8/CCL2/CXCL1/CXCL3/NOX1/MMP1/ATF4/TNFRSF10B/MYD88/HSP90B1/NFKBIA/CXCL2/IL12A/CALM1/TRAF2/PLCB1/VAV3/ERN1/MMP3/VLDLR/ATF6/HSPD1/MAP2K3/MAPK14/ICAM1/STAT3/POU2F1/CYBA/RAC1/TANK/IRF7/CAMK2D/NFKB1/MAP2K4/MAPK11/NOS3/BID/RELA	38
KEGG	hsa04064	NF-kappa B signaling pathway	22/854	104/8135	0.0009775	0.02929	0.02589	CXCL8/CXCL1/CXCL3/PARP1/IL1R1/MYD88/NFKBIA/CXCL12/CXCL2/TRAF5/TRAF2/BIRC3/CFLAR/BIRC2/TNFSF13B/ICAM1/TRIM25/NFKB1/GADD45B/PTGS2/PIAS4/RELA	22
KEGG	hsa01232	Nucleotide metabolism	19/854	85/8135	0.001062	0.02929	0.02589	NME1-NME2/NME2/AMPD2/CTPS1/NT5C3A/ENTPD1/GMPS/DUT/NTPCR/CMPK1/NME1/NME4/CTPS2/CMPK2/CANT1/RRM1/GUK1/ENTPD6/TYMP	19
KEGG	hsa00230	Purine metabolism	25/854	128/8135	0.001537	0.03914	0.0346	NME1-NME2/NME2/ADCY4/PDE10A/NUDT9/AMPD2/ENTPD1/PDE1C/PAPSS2/GMPS/ADCY6/PDE7A/NTPCR/PDE9A/NME1/NME4/CANT1/RRM1/GUK1/ENTPD6/PDE1A/PDE7B/PFAS/PDE3A/ATIC	25
KEGG	hsa05135	Yersinia infection	26/854	137/8135	0.001922	0.0444	0.03925	CXCL8/CCL2/ITGB1/MYD88/NFKBIA/GNAQ/RPS6KA3/TRAF2/VAV3/GIT2/ARPC3/MAP2K3/MAPK14/FN1/ACTG1/IL10/PIP5K1A/RAC1/NFKB1/ACTB/LIMK1/MAP2K4/BAIAP2/MAPK11/ELMO2/RELA	26
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/854	70/8135	0.002012	0.0444	0.03925	CXCL8/CXCL1/CXCL3/NFKBIA/ATP6AP1/CXCL2/JAM2/MAPK14/TJP1/RAC1/ATP6V1E1/NFKB1/ATP6V0D1/MAP2K4/MAPK11/RELA	16
KEGG	hsa04216	Ferroptosis	11/854	41/8135	0.002623	0.05427	0.04798	FTH1/ACSL4/SAT1/VDAC2/LPCAT3/CP/ATG5/GCLC/PCBP2/SLC39A14/SLC3A2	11
KEGG	hsa03030	DNA replication	10/854	36/8135	0.003079	0.05994	0.05299	MCM6/PRIM1/RFC4/POLD1/POLE4/RNASEH2C/POLD2/RFC1/POLA2/RPA3	10
KEGG	hsa03013	Nucleocytoplasmic transport	21/854	108/8135	0.003737	0.06871	0.06075	SEC13/NDC1/AAAS/NXF1/CSE1L/SAP18/NUP62/MAGOHB/NUP85/THOC6/RAN/KPNB1/SNUPN/EIF4A3/XPO7/PNN/NUP205/XPO1/NUP107/NXF3/THOC5	21
KEGG	hsa05142	Chagas disease	20/854	102/8135	0.004163	0.0689	0.06092	CXCL8/CCL2/IFNGR2/MYD88/NFKBIA/GNAQ/IL12A/BDKRB2/CFLAR/PLCB1/SERPINE1/MAPK14/GNAL/IL10/NFKB1/PPP2CB/MAP2K4/MAPK11/CALR/RELA	20
KEGG	hsa05146	Amoebiasis	20/854	102/8135	0.004163	0.0689	0.06092	CXCL8/CXCL1/CXCL3/RAB5A/IL1R1/C8G/GNAQ/CXCL2/COL1A2/IL12A/PLCB1/C8B/C9/LAMB1/GNAL/FN1/IL10/NFKB1/LAMA3/RELA	20
KEGG	hsa00510	N-Glycan biosynthesis	12/854	50/8135	0.004655	0.07337	0.06486	ALG1/B4GALT2/ALG3/ALG14/STT3B/B4GALT3/DOLPP1/MGAT2/MGAT4B/ALG9/STT3A/RPN1	12
KEGG	hsa03250	Viral life cycle - HIV-1	14/854	63/8135	0.004918	0.07399	0.06541	MLLT3/HGS/MX1/ELL2/RAN/SUPT4H1/APOBEC3F/PSIP1/NELFCD/AFF4/BICD1/APOBEC3G/XPO1/APOBEC3B	14
KEGG	hsa03040	Spliceosome	26/854	147/8135	0.005213	0.07502	0.06632	RBMX/HNRNPA3/HNRNPA1/HNRNPA1L2/SNRPE/PRPF40B/USP39/ZMAT2/SNRPD2/TRA2A/DDX46/MAGOHB/SNRPA1/SNRNP70/PRPF38B/DDX23/SRSF1/SNRPD1/EIF4A3/HNRNPM/PRPF40A/SRSF7/PPIH/DHX38/SNRNP200/U2AF2	26
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/854	100/8135	0.007309	0.1008	0.08912	CXCL8/CCL2/NOX1/COL1A2/STAT5A/PLCB1/PLCD4/AGTR1/SERPINE1/MAPK14/FN1/ICAM1/STAT3/RAC1/NFKB1/CDKN1B/MAPK11/NOS3/RELA	19
KEGG	hsa04217	Necroptosis	27/854	159/8135	0.007808	0.1027	0.09076	IFNGR2/FTH1/STAT6/PARP1/TNFRSF10B/TYK2/IFNAR2/JAK1/TRAF5/TRAF2/PLA2G4D/STAT5A/BIRC3/CFLAR/RIPK3/BIRC2/DNM1L/TLR3/STAT3/VDAC2/RNF31/PLA2G4C/CAMK2D/VDAC1/SMPD1/CHMP1B/BID	27
KEGG	hsa05014	Amyotrophic lateral sclerosis	53/854	364/8135	0.008064	0.1027	0.09076	GPX8/SEC13/NDC1/HNRNPA3/HNRNPA1/ATF4/RAB5A/NXF1/GPX3/HNRNPA1L2/MCU/CCS/NDUFB1/TRAF2/PSMA1/NDUFS3/ERN1/TUBB/NUP62/ATF6/NDUFA2/NUP85/ACTR1B/NDUFS1/MAP2K3/PSMA6/MAPK14/DNAH10/ACTG1/CAT/RAB1A/ATG2A/ANXA7/RAC1/ATP5PF/PFN2/DAXX/TANK/KLC2/TUBB4B/ACTB/SRSF7/MAPK11/DCTN5/VDAC1/NUP205/COX6A1/DNAH1/NUP107/BID/WIPI1/DNAH17/NXF3	53
KEGG	hsa05418	Fluid shear stress and atherosclerosis	24/854	139/8135	0.009572	0.1173	0.1037	CCL2/NOX1/IL1R1/HSP90B1/CALM1/ASS1/MAPK14/ACTG1/ICAM1/CYBA/RAC1/PECAM1/NFKB1/ACTB/MAP2K4/MAPK11/BMPR1A/ACVR2A/MGST3/NOS3/PIAS4/RELA/PDGFA/MAPK7	24
KEGG	hsa04144	Endocytosis	38/854	251/8135	0.01265	0.1495	0.1322	RAB5A/CLTC/SNX12/RAB22A/VPS26B/PML/HGS/GIT2/PDGFRA/DAB2/ARPC3/VPS26A/CBLB/LDLRAP1/RAB11B/PLD1/EPN1/FGFR4/CLTCL1/PIP5K1A/SNX6/SMAP2/VPS35/WASHC2A/CYTH1/RAB4A/SMURF1/CHMP1B/RAB10/ARRB1/ARAP2/WASHC4/SNX2/RAB35/PSD4/HLA-F/EHD1/VPS37A	38
KEGG	hsa05134	Legionellosis	12/854	57/8135	0.01371	0.1547	0.1368	CXCL8/CXCL1/CXCL3/MYD88/NFKBIA/CXCL2/IL12A/HSPD1/RAB1A/NFKB1/HSF1/RELA	12
KEGG	hsa00670	One carbon pool by folate	6/854	20/8135	0.01402	0.1547	0.1368	MTHFD1/DHFR2/MTHFD2/SHMT2/ALDH1L2/ATIC	6
KEGG	hsa04912	GnRH signaling pathway	17/854	93/8135	0.01571	0.1623	0.1435	ADCY4/ATF4/GNAQ/ELK1/CALM1/PLA2G4D/ADCY6/PLCB1/MAP2K3/MAP3K4/MAPK14/PLD1/PLA2G4C/CAMK2D/MAP2K4/MAPK11/MAPK7	17
KEGG	hsa05323	Rheumatoid arthritis	17/854	93/8135	0.01571	0.1623	0.1435	CXCL8/CCL2/CXCL1/CXCL3/MMP1/CCL20/CXCL12/ATP6AP1/CXCL2/CXCL6/IL23A/MMP3/TNFSF13B/CXCL5/ICAM1/ATP6V1E1/ATP6V0D1	17
KEGG	hsa03018	RNA degradation	15/854	79/8135	0.01618	0.1623	0.1435	EXOSC8/CNOT4/XRN2/TTC37/BTG3/PNPT1/HSPD1/PAN2/PFKP/ENO2/BTG1/DCP1A/SKIV2L/HSPA9/PAN3	15
KEGG	hsa05132	Salmonella infection	37/854	249/8135	0.01812	0.1764	0.1559	CXCL8/RAB5A/TNFRSF10B/MYD88/HSP90B1/NFKBIA/SNX9/CSE1L/TRAF2/BIRC3/RIPK3/RIPK2/TUBB/ARPC3/VPS39/BIRC2/ACTR1B/MAP2K3/MAPK14/ACTG1/ACBD3/RAC1/PFN2/KLC2/NFKB1/TUBB4B/RPS3/ACTB/MAP2K4/MAPK11/CYTH1/DCTN5/ANXA2/CYFIP1/DYNC1LI1/ELMO2/RELA	37
KEGG	hsa00514	Other types of O-glycan biosynthesis	10/854	47/8135	0.02182	0.2006	0.1773	B4GALT2/POFUT2/B4GALT3/GALNT15/GALNT1/EOGT/POGLUT1/C1GALT1/GALNT4/POC1B-GALNT4	10
KEGG	hsa03420	Nucleotide excision repair	10/854	47/8135	0.02182	0.2006	0.1773	RFC4/POLD1/POLE4/BIVM-ERCC5/POLD2/CDK7/ERCC5/RFC1/ERCC6/RPA3	10
KEGG	hsa05130	Pathogenic Escherichia coli infection	30/854	197/8135	0.02304	0.2061	0.1822	CXCL8/ITGB1/IL1R1/TNFRSF10B/CTTN/MYD88/NFKBIA/MYO1B/TRAF2/TUBB/ARPC3/MYO10/MAPK14/ACTG1/TMBIM6/RAB1A/TJP1/MYH14/RAC1/CLDN1/NFKB1/TUBB4B/RPS3/ACTB/BAIAP2/MAPK11/CYTH1/CYFIP1/RELA/SEC24D	30
KEGG	hsa05133	Pertussis	14/854	76/8135	0.02523	0.2156	0.1906	CXCL8/ITGB1/MYD88/CFL2/CXCL6/IL12A/CALM1/IL23A/CXCL5/MAPK14/IL10/NFKB1/MAPK11/RELA	14
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	17/854	98/8135	0.0254	0.2156	0.1906	ADCY4/IL1R1/GNAQ/CALM1/PLA2G4D/BDKRB2/TRPA1/ADCY6/PLCB1/IGF1/MAP2K3/MAPK14/HTR2A/PLA2G4C/CAMK2D/HRH1/MAPK11	17
KEGG	hsa03060	Protein export	6/854	23/8135	0.02784	0.2194	0.194	SEC61A1/IMMP2L/SRP72/SPCS3/SEC61G/SRP9	6
KEGG	hsa03430	Mismatch repair	6/854	23/8135	0.02784	0.2194	0.194	RFC4/POLD1/MLH1/POLD2/RFC1/RPA3	6
KEGG	hsa05140	Leishmaniasis	14/854	77/8135	0.02798	0.2194	0.194	IFNGR2/ITGB1/MYD88/NFKBIA/ELK1/IL12A/JAK1/MAPK14/IL10/CYBA/NFKB1/MAPK11/PTGS2/RELA	14
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	10/854	49/8135	0.02862	0.2194	0.194	NAGK/CYB5R2/GMPPA/GNPNAT1/GMDS/GALE/GPI/GNPDA2/GMPPB/GFPT1	10
KEGG	hsa05163	Human cytomegalovirus infection	33/854	225/8135	0.02916	0.2194	0.194	CXCL8/CCL2/ADCY4/ATF4/IL1R1/NFKBIA/GNAQ/CXCL12/GNB3/ELK1/CALM1/CDKN1A/JAK1/TRAF5/TRAF2/SP1/ADCY6/PLCB1/PDGFRA/MAPK14/STAT3/RPS6KB1/PDIA3/RAC1/NFKB1/MAPK11/CDKN2A/CREB3L2/CALR/PTGS2/BID/RELA/HLA-F	33
KEGG	hsa00020	Citrate cycle (TCA cycle)	7/854	30/8135	0.0324	0.2292	0.2026	FH/ACO2/CS/IDH1/SUCLA2/SUCLG2/PDHB	7
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	7/854	30/8135	0.0324	0.2292	0.2026	GCSH/ACO2/ACAT1/CS/PGP/CAT/SHMT2	7
KEGG	hsa05110	Vibrio cholerae infection	10/854	50/8135	0.03254	0.2292	0.2026	ATP6AP1/KDELR1/SEC61A1/ACTG1/TJP1/ATP6V1E1/SLC12A2/ACTB/ATP6V0D1/SEC61G	10
KEGG	hsa01250	Biosynthesis of nucleotide sugars	8/854	37/8135	0.03504	0.2416	0.2136	NAGK/GMPPA/GNPNAT1/GMDS/GALE/GPI/GMPPB/GFPT1	8
KEGG	hsa04936	Alcoholic liver disease	22/854	142/8135	0.03962	0.2677	0.2366	CXCL8/CXCL1/CXCL3/MYD88/NFKBIA/CXCL2/IL12A/TRA2A/MAP2K3/ALDH3A2/MAPK14/PRKAG1/ACADVL/ADH5/NFKB1/MAP2K4/MAPK11/ACACB/PPARA/ADIPOR2/SCD/RELA	22
KEGG	hsa05145	Toxoplasmosis	18/854	112/8135	0.04327	0.2811	0.2485	IFNGR2/ITGB1/TYK2/MYD88/NFKBIA/IL12A/JAK1/BIRC3/BIRC2/LAMB1/MAP2K3/MAPK14/STAT3/IL10/NFKB1/MAPK11/LAMA3/RELA	18
KEGG	hsa05168	Herpes simplex virus 1 infection	64/854	495/8135	0.04331	0.2811	0.2485	CCL2/IFNGR2/NXF1/TYK2/MYD88/ZNF83/NFKBIA/IFNAR2/IL12A/JAK1/TRAF5/TRAF2/PML/ZNF605/ZNF583/BIRC3/IFIH1/PILRA/BIRC2/ZNF567/ZNF415/ZNF268/ZNF175/ZNF227/ZNF33B/ZNF26/ZNF791/TLR3/ZNF317/ZNF845/ZNF761/ZNF84/SRSF1/ZNF224/ZNF680/POU2F1/PDIA3/SP100/NECTIN2/ZNF136/ZNF180/DAXX/IRF7/NFKB1/ZNF267/SRSF7/ZNF85/ZNF727/ZNF829/ZNF600/ZNF10/ZNF460/CALR/ZNF282/ZNF135/HCFC2/ZNF45/ZNF630/BID/RELA/NXF3/ZNF41/ZNF44/HLA-F	64
KEGG	hsa03015	mRNA surveillance pathway	16/854	97/8135	0.04453	0.2835	0.2506	SSU72/NXF1/BCL2L2-PABPN1/PABPN1/PCF11/DAZAP1/SAP18/MAGOHB/CPSF1/EIF4A3/PPP2R5B/PNN/PPP2CB/MSI2/PAPOLA/NXF3	16
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/854	194/8135	0.04998	0.3122	0.276	CXCL8/CXCL1/CXCL3/TYK2/NFKBIA/GNB3/IFNAR2/FGF2/CXCL2/CALM1/CDKN1A/JAK1/TRAF2/TLR3/MAPK14/ICAM1/STAT3/RAC1/IRF7/NFKB1/MAP2K4/MAPK11/MICA/PTGS2/BID/RELA/HLA-F/UBC	28
KEGG	hsa01200	Carbon metabolism	18/854	115/8135	0.05394	0.3306	0.2923	GCSH/FH/ACO2/ACAT1/CS/IDH1/PGP/SUCLA2/PSAT1/PFKP/ENO2/CAT/GPI/ADH5/SUCLG2/SHMT2/PDHB/PGD	18
KEGG	hsa05222	Small cell lung cancer	15/854	92/8135	0.05517	0.332	0.2936	ITGB1/NFKBIA/CDKN1A/TRAF5/TRAF2/BIRC3/BIRC2/LAMB1/FN1/NFKB1/GADD45B/CDKN1B/PTGS2/LAMA3/RELA	15
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/854	100/8135	0.05638	0.3333	0.2946	CXCL8/CCL2/CCL7/CXCL1/CXCL3/TNFRSF10B/CCL20/CXCL12/CXCL2/CXCL6/IL24/CXCL5/IL10/ACKR3/IL18R1/CXCR5	16
KEGG	hsa03440	Homologous recombination	8/854	41/8135	0.05994	0.3481	0.3077	BRCA2/POLD1/RAD52/RAD51D/ABRAXAS1/POLD2/RAD50/RPA3	8
KEGG	hsa00730	Thiamine metabolism	4/854	15/8135	0.06429	0.3669	0.3244	NTPCR/NFS1/THTPA/TPK1	4
KEGG	hsa04071	Sphingolipid signaling pathway	18/854	119/8135	0.07086	0.3855	0.3408	SPTLC3/NSMAF/GNAQ/TRAF2/BDKRB2/PLCB1/MAPK14/PLD1/RAC1/MS4A2/PPP2R5B/NFKB1/PPP2CB/MAPK11/SMPD1/NOS3/BID/RELA	18
KEGG	hsa04810	Regulation of actin cytoskeleton	30/854	218/8135	0.07306	0.3855	0.3408	ITGB1/FGF7/CFL2/CXCL12/FGF2/PPP1R12C/SSH2/BDKRB2/ENAH/TMSB4X/VAV3/PDGFRA/ARPC3/FN1/ACTG1/FGFR4/ABI2/MYH14/PIP5K1A/RAC1/PAK4/ITGA7/PFN2/ACTB/LIMK1/BAIAP2/CYFIP1/IQGAP1/FGD1/PDGFA	30
KEGG	hsa05144	Malaria	9/854	50/8135	0.07348	0.3855	0.3408	CXCL8/CCL2/CSF3/MYD88/IL12A/ICAM1/IL10/THBS2/PECAM1	9
KEGG	hsa04145	Phagosome	22/854	152/8135	0.07385	0.3855	0.3408	ITGB1/RAB5A/ATP6AP1/HGS/TUBB/SEC61A1/ACTG1/CYBA/THBS2/RAC1/ATP6V1E1/TUBB4B/ACTB/ATP6V0D1/STX7/SEC61G/FCAR/CALR/DYNC1LI1/MARCO/CANX/HLA-F	22
KEGG	hsa05321	Inflammatory bowel disease	11/854	65/8135	0.07414	0.3855	0.3408	IFNGR2/STAT6/NOD2/IL12A/IL23A/IL4R/STAT3/IL10/NFKB1/IL18R1/RELA	11
KEGG	hsa00512	Mucin type O-glycan biosynthesis	7/854	36/8135	0.07703	0.3855	0.3408	ST6GALNAC4/GALNT15/GCNT4/GALNT1/C1GALT1/GALNT4/POC1B-GALNT4	7
KEGG	hsa00480	Glutathione metabolism	10/854	58/8135	0.07782	0.3855	0.3408	GPX8/GPX3/IDH1/GGCT/RRM1/ODC1/GCLC/LAP3/MGST3/PGD	10
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/854	16/8135	0.07887	0.3855	0.3408	FMO5/FMO3/BAAT/CDO1	4
KEGG	hsa05415	Diabetic cardiomyopathy	28/854	203/8135	0.07935	0.3855	0.3408	PARP1/COL1A2/NDUFB1/ATP2A2/SP1/NDUFS3/PLCB1/NDUFA2/AGTR1/NDUFS1/MAPK14/VDAC2/PDK3/CYBA/RAC1/ATP5PF/TBC1D4/CAMK2D/NFKB1/ATP2A3/MAPK11/VDAC1/PPARA/COX6A1/NOS3/PDHB/GFPT1/RELA	28
KEGG	hsa00270	Cysteine and methionine metabolism	9/854	51/8135	0.08133	0.3855	0.3408	APIP/IL4I1/PSAT1/MAT2A/CDO1/DNMT3B/BCAT1/CTH/GCLC	9
KEGG	hsa04630	JAK-STAT signaling pathway	23/854	162/8135	0.08153	0.3855	0.3408	CSF3/IFNGR2/STAT6/TYK2/IFNAR2/IL12A/IL23A/IL24/CDKN1A/JAK1/IL4R/STAT5A/PDGFRA/SOCS6/SOCS5/STAT3/OSMR/IL10/IL11RA/IL7/PIAS3/PIAS4/PDGFA	23
KEGG	hsa05161	Hepatitis B	23/854	162/8135	0.08153	0.3855	0.3408	CXCL8/STAT6/ATF4/TYK2/MYD88/NFKBIA/ATP6AP1/ELK1/CDKN1A/JAK1/STAT5A/IFIH1/TLR3/MAP2K3/MAPK14/STAT3/IRF7/NFKB1/MAP2K4/MAPK11/CREB3L2/BID/RELA	23
KEGG	hsa05143	African trypanosomiasis	7/854	37/8135	0.08683	0.4035	0.3567	MYD88/GNAQ/IL12A/PLCB1/ICAM1/APOL1/IL10	7
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	30/854	222/8135	0.08778	0.4035	0.3567	ADCY4/ATF4/IL1R1/NFKBIA/ELK1/CRTC2/CHEK2/CDKN1A/JAK1/ADCY6/STAT5A/DLG1/KAT5/ANAPC2/RAN/MAD2L1/ICAM1/VDAC2/TRRAP/ANAPC1/NFKB1/MAP2K4/VDAC1/CDKN2A/CREB3L2/CALR/CANX/XPO1/RELA/HLA-F	30
KEGG	hsa00450	Selenocompound metabolism	4/854	17/8135	0.09494	0.4305	0.3806	SEPSECS/TXNRD3/PAPSS2/CTH	4
KEGG	hsa04931	Insulin resistance	16/854	108/8135	0.09807	0.4387	0.3878	NFKBIA/RPS6KA3/CRTC2/SLC27A1/STAT3/PRKAG1/RPS6KB1/TBC1D4/NFKB1/ACACB/PPARA/PPP1R3E/CREB3L2/NOS3/GFPT1/RELA	16
KEGG	hsa04066	HIF-1 signaling pathway	16/854	109/8135	0.1044	0.4587	0.4055	IFNGR2/CDKN1A/IGF1/PFKP/SERPINE1/ENO2/STAT3/RPS6KB1/CAMK2D/NFKB1/CDKN1B/VHL/ARNT/NOS3/PDHB/RELA	16
KEGG	hsa04120	Ubiquitin mediated proteolysis	20/854	142/8135	0.1053	0.4587	0.4055	UBE2E1/TRIM32/UBE2Q2/PML/BIRC3/MGRN1/BIRC2/ANAPC2/UBE2Z/CBLB/UBE2H/ANAPC1/RHOBTB1/UBE2K/VHL/SMURF1/PIAS3/PPIL2/PIAS4/UBC	20
KEGG	hsa04136	Autophagy - other	6/854	32/8135	0.1124	0.477	0.4217	ATG4B/ATG16L1/ATG2A/PPP2CB/ATG5/WIPI1	6
KEGG	hsa00061	Fatty acid biosynthesis	4/854	18/8135	0.1124	0.477	0.4217	ACSL4/ACACB/CBR4/MECR	4
KEGG	hsa05170	Human immunodeficiency virus 1 infection	28/854	212/8135	0.1187	0.4975	0.4398	MYD88/CFL2/NFKBIA/GNAQ/GNB3/CALM1/TRAF5/TRAF2/AP1M1/CCNB1/MAP2K3/WEE1/MAPK14/RPS6KB1/PDIA3/RAC1/PAK4/APOBEC3F/AP1S2/NFKB1/LIMK1/MAPK11/APOBEC3G/CALR/APOBEC3B/BID/RELA/HLA-F	28
KEGG	hsa05131	Shigellosis	32/854	247/8135	0.1217	0.5037	0.4453	CXCL8/ITGB1/IL1R1/CBX3/CTTN/MYD88/NFKBIA/TRAF5/TRAF2/PLCB1/RIPK2/ARPC3/PLCD4/SEPTIN6/UBE2V1/MAPK14/ACTG1/RPS6KB1/ATG16L1/RNF31/RAC1/PFN2/NFKB1/ACTB/ATG5/MAPK11/CYTH1/VDAC1/ELMO2/RELA/WIPI1/UBC	32
KEGG	hsa00280	Valine, leucine and isoleucine degradation	8/854	48/8135	0.125	0.5081	0.4492	MCCC2/ACAT1/IL4I1/HSD17B10/DBT/ALDH3A2/BCAT1/ACAA2	8
KEGG	hsa04130	SNARE interactions in vesicular transport	6/854	33/8135	0.1259	0.5081	0.4492	VAMP1/BET1/STX17/STX7/VAMP4/VTI1B	6
KEGG	hsa05152	Tuberculosis	24/854	180/8135	0.1301	0.5169	0.457	RFX5/IFNGR2/RAB5A/PLK3/MYD88/RFXAP/ATP6AP1/NOD2/IL12A/CALM1/IL23A/JAK1/IRAK2/RIPK2/HSPD1/MAPK14/IL10/CAMK2D/NFKB1/ATP6V0D1/HSPA9/MAPK11/BID/RELA	24
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/854	19/8135	0.1312	0.5169	0.457	ACO2/CS/IDH1/BCAT1	4
KEGG	hsa05171	Coronavirus disease - COVID-19	30/854	232/8135	0.1328	0.5173	0.4574	CXCL8/CCL2/CSF3/MMP1/TYK2/MYD88/C8G/NFKBIA/IFNAR2/CFB/IL12A/JAK1/C8B/MMP3/IFIH1/C9/MX1/AGTR1/TLR3/MAPK14/STAT3/RPL13/RPL13A/NFKB1/RPS3/MASP2/MAPK11/RPL38/RPL24/RELA	30
KEGG	hsa00565	Ether lipid metabolism	8/854	49/8135	0.1365	0.5179	0.4578	LPCAT2/LPCAT4/PLA2G4D/TMEM189-UBE2V1/PLD1/PLA2G4C/PLD3/GDPD3	8
KEGG	hsa04211	Longevity regulating pathway	13/854	89/8135	0.1372	0.5179	0.4578	ADCY4/ATF4/ADCY6/IGF1/APPL1/PRKAG1/RPS6KB1/CAT/NFKB1/ATG5/CREB3L2/ADIPOR2/RELA	13
KEGG	hsa04115	p53 signaling pathway	11/854	73/8135	0.1392	0.5179	0.4578	PMAIP1/TNFRSF10B/CHEK2/CDKN1A/IGF1/CCNB1/SERPINE1/CCNG1/GADD45B/CDKN2A/BID	11
KEGG	hsa04218	Cellular senescence	21/854	156/8135	0.1392	0.5179	0.4578	CXCL8/MCU/CALM1/CHEK2/CDKN1A/CCNB1/SERPINE1/MAP2K3/MAPK14/VDAC2/NFKB1/GADD45B/MAPK11/TRAF3IP2/VDAC1/CDKN2A/LIN54/RAD50/FOXM1/RELA/HLA-F	21
KEGG	hsa04114	Oocyte meiosis	18/854	131/8135	0.1415	0.5203	0.46	ADCY4/FBXO5/RPS6KA3/CALM1/ADCY6/IGF1/CCNB1/PKMYT1/ANAPC2/MAPK14/MAD2L1/SPDYE6/ANAPC1/PPP2R5B/CAMK2D/SPDYE11/PPP2CB/MAPK11	18
KEGG	hsa04659	Th17 cell differentiation	15/854	108/8135	0.1582	0.5664	0.5008	IFNGR2/STAT6/IL1R1/TYK2/NFKBIA/IL23A/JAK1/IL4R/STAT5A/MAPK14/RARA/STAT3/NFKB1/MAPK11/RELA	15
KEGG	hsa05169	Epstein-Barr virus infection	26/854	202/8135	0.1588	0.5664	0.5008	TYK2/MYD88/NFKBIA/IFNAR2/CDKN1A/JAK1/ENTPD1/TRAF5/TRAF2/CIR1/MAP2K3/MAPK14/ICAM1/STAT3/PDIA3/RAC1/IRF7/NFKB1/GADD45B/CDKN1B/MAP2K4/MAPK11/CALR/BID/RELA/HLA-F	26
KEGG	hsa01230	Biosynthesis of amino acids	11/854	75/8135	0.1591	0.5664	0.5008	ACO2/ASS1/CS/IDH1/PSAT1/PFKP/MAT2A/ENO2/BCAT1/CTH/SHMT2	11
KEGG	hsa04913	Ovarian steroidogenesis	8/854	51/8135	0.1611	0.5671	0.5014	ADCY4/PLA2G4D/ADCY6/IGF1/CYP1B1/PLA2G4C/ACOT2/PTGS2	8
KEGG	hsa04658	Th1 and Th2 cell differentiation	13/854	92/8135	0.1643	0.5724	0.506	IFNGR2/STAT6/TYK2/NFKBIA/IL12A/JAK1/IL4R/STAT5A/JAG2/MAPK14/NFKB1/MAPK11/RELA	13
KEGG	hsa04110	Cell cycle	17/854	126/8135	0.1677	0.5782	0.5112	CDC6/MCM6/CHEK2/CDKN1A/CCNB1/PKMYT1/ANAPC2/WEE1/MAD2L1/ANAPC1/CDK7/GADD45B/TFDP2/CDKN1B/CDKN2A/ORC4/CDC14B	17
KEGG	hsa05212	Pancreatic cancer	11/854	76/8135	0.1696	0.5788	0.5117	CDKN1A/JAK1/BRCA2/PLD1/STAT3/RPS6KB1/RAC1/NFKB1/GADD45B/CDKN2A/RELA	11
KEGG	hsa04020	Calcium signaling pathway	30/854	240/8135	0.1775	0.5912	0.5227	ADCY4/ATP2B1/ADORA2A/FGF7/MCU/GNAQ/FGF2/CALM1/PDE1C/ATP2A2/BDKRB2/PLCB1/PDGFRA/ORAI3/PLCD4/AGTR1/P2RX1/GNAL/MST1/HTR2A/VDAC2/FGFR4/PHKB/CAMK2D/HRH1/ATP2A3/VDAC1/PDE1A/NOS3/PDGFA	30
KEGG	hsa04210	Apoptosis	18/854	136/8135	0.1797	0.5912	0.5227	PMAIP1/PARP1/ATF4/TNFRSF10B/NFKBIA/TRAF2/BIRC3/CFLAR/ERN1/BIRC2/SPTAN1/ACTG1/DAXX/NFKB1/ACTB/GADD45B/BID/RELA	18
KEGG	hsa04914	Progesterone-mediated oocyte maturation	14/854	102/8135	0.1797	0.5912	0.5227	ADCY4/RPS6KA3/ADCY6/IGF1/CCNB1/PKMYT1/ANAPC2/MAPK14/MAD2L1/SPDYE6/ANAPC1/STK10/SPDYE11/MAPK11	14
KEGG	hsa05100	Bacterial invasion of epithelial cells	11/854	77/8135	0.1804	0.5912	0.5227	ITGB1/CLTC/CTTN/ARPC3/SEPTIN6/FN1/ACTG1/CLTCL1/RAC1/ACTB/ELMO2	11
KEGG	hsa04920	Adipocytokine signaling pathway	10/854	69/8135	0.1833	0.5948	0.5259	NFKBIA/TRAF2/ACSL4/STAT3/PRKAG1/NFKB1/ACACB/PPARA/ADIPOR2/RELA	10
KEGG	hsa04620	Toll-like receptor signaling pathway	14/854	104/8135	0.199	0.6395	0.5654	CXCL8/MYD88/NFKBIA/IFNAR2/IL12A/TLR3/MAP2K3/MAPK14/RAC1/IRF7/NFKB1/MAP2K4/MAPK11/RELA	14
KEGG	hsa01523	Antifolate resistance	5/854	30/8135	0.2014	0.641	0.5667	DHFR2/NFKB1/SHMT2/RELA/ATIC	5
KEGG	hsa04068	FoxO signaling pathway	17/854	131/8135	0.2107	0.6642	0.5872	PLK3/FBXO32/CDKN1A/STK4/IGF1/CCNB1/SGK1/PLK4/PLK2/MAPK14/STAT3/PRKAG1/IL10/CAT/GADD45B/CDKN1B/MAPK11	17
KEGG	hsa05215	Prostate cancer	13/854	97/8135	0.2147	0.6705	0.5928	NKX3-1/ATF4/HSP90B1/NFKBIA/CDKN1A/MMP3/IGF1/PDGFRA/NFKB1/CDKN1B/CREB3L2/RELA/PDGFA	13
KEGG	hsa00620	Pyruvate metabolism	7/854	47/8135	0.2188	0.676	0.5977	AKR1A1/FH/ACAT1/ALDH3A2/ADH5/ACACB/PDHB	7
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/854	89/8135	0.2206	0.676	0.5977	IFNGR2/MYD88/NFKBIA/JAK1/CD274/MAP2K3/MAPK14/STAT3/RPS6KB1/NFKB1/MAPK11/RELA	12
KEGG	hsa04611	Platelet activation	16/854	124/8135	0.2264	0.6875	0.6078	ITGB1/ADCY4/GNAQ/COL1A2/APBB1IP/PLA2G4D/GP1BB/ADCY6/PLCB1/P2RX1/MAPK14/ACTG1/PLA2G4C/ACTB/MAPK11/NOS3	16
KEGG	hsa05017	Spinocerebellar ataxia	18/854	143/8135	0.2409	0.7245	0.6405	MCU/GNAQ/GTF2B/TRAF2/ATP2A2/SP1/PSMA1/PLCB1/ERN1/VLDLR/KAT5/PSMA6/VDAC2/ATG2A/PUM2/ATP2A3/VDAC1/WIPI1	18
KEGG	hsa04060	Cytokine-cytokine receptor interaction	35/854	295/8135	0.2433	0.7245	0.6405	CXCL8/CCL2/CSF3/CCL7/CXCL1/TNFSF8/IFNGR2/CXCL3/IL1R1/TNFRSF10B/CCL20/CXCL12/IFNAR2/CXCL2/CXCL6/IL17C/IL12A/IL23A/IL24/TNFRSF4/IL4R/GDF15/TNFSF13B/IL1RL1/CXCL5/OSMR/IL10/IL11RA/IL7/BMPR1A/ACKR3/IL18R1/TNFRSF8/ACVR2A/CXCR5	35
KEGG	hsa01212	Fatty acid metabolism	8/854	57/8135	0.2451	0.7245	0.6405	HSD17B4/ACSL4/ACAT1/ACADVL/ACAA2/CBR4/SCD/MECR	8
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	14/854	109/8135	0.2512	0.7358	0.6505	SNORD3A/SNORD3B-1/SNORD3B-2/SNORD3C/WDR75/NXF1/XRN2/GNL3/EFL1/RAN/POP5/RPP30/XPO1/NXF3	14
KEGG	hsa04918	Thyroid hormone synthesis	10/854	75/8135	0.2591	0.7465	0.66	GPX8/ADCY4/ATF4/GPX3/HSP90B1/GNAQ/ADCY6/PLCB1/CREB3L2/CANX	10
KEGG	hsa00120	Primary bile acid biosynthesis	3/854	17/8135	0.2616	0.7465	0.66	HSD17B4/BAAT/ACOX2	3
KEGG	hsa03410	Base excision repair	5/854	33/8135	0.2616	0.7465	0.66	PARP1/POLD1/POLE4/APEX1/POLD2	5
KEGG	hsa04722	Neurotrophin signaling pathway	15/854	119/8135	0.2646	0.7486	0.6618	ATF4/NFKBIA/RPS6KA3/CALM1/IRAK2/MAGED1/RIPK2/PSEN1/MAPK14/RAC1/CAMK2D/NFKB1/MAPK11/RELA/MAPK7	15
KEGG	hsa04926	Relaxin signaling pathway	16/854	129/8135	0.277	0.7606	0.6724	MMP1/ADCY4/ATF4/NFKBIA/GNB3/COL1A2/ADCY6/PLCB1/MAPK14/NFKB1/MAP2K4/MAPK11/ARRB1/CREB3L2/NOS3/RELA	16
KEGG	hsa04350	TGF-beta signaling pathway	12/854	94/8135	0.2801	0.7606	0.6724	DCN/SP1/FBN1/ID3/RPS6KB1/LTBP1/SMAD6/PPP2CB/SMURF1/BMPR1A/ACVR2A/TGIF2	12
KEGG	hsa04015	Rap1 signaling pathway	25/854	210/8135	0.2812	0.7606	0.6724	ITGB1/ADCY4/ADORA2A/FGF7/GNAQ/FGF2/CALM1/APBB1IP/ENAH/ADCY6/PLCB1/VAV3/IGF1/PDGFRA/MAGI3/SIPA1L2/MAP2K3/MAPK14/ACTG1/FGFR4/RAC1/PFN2/ACTB/MAPK11/PDGFA	25
KEGG	hsa04062	Chemokine signaling pathway	23/854	192/8135	0.2813	0.7606	0.6724	CXCL8/CCL2/CCL7/CXCL1/CXCL3/ADCY4/CCL20/NFKBIA/GNAQ/CXCL12/GNB3/CXCL2/CXCL6/ADCY6/PLCB1/VAV3/CXCL5/STAT3/RAC1/NFKB1/ARRB1/RELA/CXCR5	23
KEGG	hsa04664	Fc epsilon RI signaling pathway	9/854	68/8135	0.2819	0.7606	0.6724	PLA2G4D/VAV3/MAP2K3/MAPK14/PLA2G4C/RAC1/MS4A2/MAP2K4/MAPK11	9
KEGG	hsa00920	Sulfur metabolism	2/854	10/8135	0.2832	0.7606	0.6724	PAPSS2/BPNT1	2
KEGG	hsa00330	Arginine and proline metabolism	7/854	51/8135	0.2849	0.7606	0.6724	SAT1/ALDH3A2/L3HYPDH/ODC1/LAP3/NOS3/GATM	7
KEGG	hsa00071	Fatty acid degradation	6/854	43/8135	0.2943	0.7741	0.6843	ACSL4/ACAT1/ALDH3A2/ACADVL/ADH5/ACAA2	6
KEGG	hsa04625	C-type lectin receptor signaling pathway	13/854	104/8135	0.2947	0.7741	0.6843	PLK3/NFKBIA/BCL3/IL12A/CALM1/IL23A/CBLB/MAPK14/IL10/NFKB1/MAPK11/PTGS2/RELA	13
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/854	27/8135	0.3133	0.7999	0.7072	B4GALT2/A4GALT/B4GALT3/ST3GAL6	4
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/854	27/8135	0.3133	0.7999	0.7072	HSD17B4/BAAT/ACOT2/SCD	4
KEGG	hsa04962	Vasopressin-regulated water reabsorption	6/854	44/8135	0.3133	0.7999	0.7072	RAB5A/ADCY6/RAB11B/DCTN5/CREB3L2/DYNC1LI1	6
KEGG	hsa04512	ECM-receptor interaction	11/854	88/8135	0.3166	0.7999	0.7072	ITGB1/AGRN/COL1A2/GP1BB/LAMB1/FN1/COL9A2/THBS2/ITGA7/FRAS1/LAMA3	11
KEGG	hsa04540	Gap junction	11/854	88/8135	0.3166	0.7999	0.7072	ADCY4/GNAQ/ADCY6/PLCB1/TUBB/PDGFRA/HTR2A/TJP1/TUBB4B/PDGFA/MAPK7	11
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/854	53/8135	0.3196	0.8015	0.7086	ATP2B1/CLTC/GNAQ/BDKRB2/ADCY6/PLCB1/CLTCL1	7
KEGG	hsa00983	Drug metabolism - other enzymes	10/854	80/8135	0.3288	0.8124	0.7182	NME1-NME2/NME2/GMPS/DUT/CMPK1/NME1/NME4/RRM1/TYMP/MGST3	10
KEGG	hsa01522	Endocrine resistance	12/854	98/8135	0.3309	0.8124	0.7182	ADCY4/CYP2D7/CDKN1A/SP1/ADCY6/IGF1/JAG2/MAPK14/RPS6KB1/CDKN1B/MAPK11/CDKN2A	12
KEGG	hsa04922	Glucagon signaling pathway	13/854	107/8135	0.3313	0.8124	0.7182	ATF4/GNAQ/CRTC2/CALM1/PLCB1/PFKP/PRKAG1/PHKB/CAMK2D/ACACB/PPARA/CREB3L2/PDHB	13
KEGG	hsa04623	Cytosolic DNA-sensing pathway	8/854	63/8135	0.3402	0.8161	0.7215	NFKBIA/POLR3H/RIPK3/POLR2K/IRF7/NFKB1/POLR3B/RELA	8
KEGG	hsa04137	Mitophagy - animal	9/854	72/8135	0.3421	0.8161	0.7215	ATF4/USP15/MITF/SP1/TBC1D15/FIS1/ATG5/RELA/UBC	9
KEGG	hsa05218	Melanoma	9/854	72/8135	0.3421	0.8161	0.7215	FGF7/FGF2/CDKN1A/MITF/IGF1/PDGFRA/GADD45B/CDKN2A/PDGFA	9
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	53/854	476/8135	0.3427	0.8161	0.7215	GPX8/NOX1/ATF4/RAB5A/GPX3/MCU/GNAQ/CCS/CALM1/NDUFB1/TRAF2/ATP2A2/PSMA1/NDUFS3/PLCB1/ERN1/TUBB/HSD17B10/ATF6/NDUFA2/PSEN1/ACTR1B/NDUFS1/MAP2K3/PSMA6/MAPK14/DNAH10/VDAC2/CAT/RAB1A/ATG2A/RAC1/ATP5PF/DAXX/TANK/CAMK2D/KLC2/NFKB1/TUBB4B/ATP2A3/MAPK11/DCTN5/VDAC1/COX6A1/DNAH1/PTGS2/SLC6A3/BID/RELA/WIPI1/DNAH17/WNT2/UBC	53
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	5/854	37/8135	0.347	0.8194	0.7244	ASS1/IL4I1/GLS/CAD/GFPT1	5
KEGG	hsa04921	Oxytocin signaling pathway	18/854	154/8135	0.3508	0.8194	0.7244	ADCY4/GNAQ/ELK1/PPP1R12C/CALM1/CDKN1A/PLA2G4D/ADCY6/PLCB1/KCNJ12/ACTG1/PRKAG1/PLA2G4C/CAMK2D/ACTB/PTGS2/NOS3/MAPK7	18
KEGG	hsa00100	Steroid biosynthesis	3/854	20/8135	0.3515	0.8194	0.7244	LBR/CYP24A1/LSS	3
KEGG	hsa05032	Morphine addiction	11/854	91/8135	0.3575	0.8276	0.7317	ADCY4/PDE10A/GNB3/PDE1C/ADCY6/PDE7A/GABRE/PDE1A/ARRB1/PDE7B/PDE3A	11
KEGG	hsa04932	Non-alcoholic fatty liver disease	18/854	155/8135	0.3614	0.8307	0.7344	CXCL8/ATF4/NDUFB1/TRAF2/NDUFS3/ERN1/NDUFA2/NDUFS1/MAPK14/PRKAG1/RAC1/NFKB1/MAPK11/PPARA/COX6A1/ADIPOR2/BID/RELA	18
KEGG	hsa04380	Osteoclast differentiation	15/854	128/8135	0.3661	0.8333	0.7367	IFNGR2/NOX1/IL1R1/TYK2/NFKBIA/IFNAR2/JAK1/TRAF2/MITF/MAPK14/CYBA/RAC1/NFKB1/MAPK11/RELA	15
KEGG	hsa04010	MAPK signaling pathway	33/854	294/8135	0.3676	0.8333	0.7367	AREG/MAP3K12/MAPK8IP3/ATF4/IL1R1/FGF7/MYD88/RPS6KA3/FGF2/ELK1/STK4/TRAF2/PLA2G4D/IGF1/PDGFRA/MAP2K3/MAP3K4/MAPK14/PPM1A/FGFR4/PLA2G4C/RAC1/DAXX/NFKB1/GADD45B/MAP2K4/MAPK11/ARRB1/RELA/LAMTOR3/PDGFA/MAPK8IP1/MAPK7	33
KEGG	hsa04927	Cortisol synthesis and secretion	8/854	65/8135	0.3732	0.8368	0.7398	ADCY4/ATF4/GNAQ/SP1/ADCY6/PLCB1/AGTR1/CREB3L2	8
KEGG	hsa04152	AMPK signaling pathway	14/854	120/8135	0.3797	0.8368	0.7398	CRTC2/IGF1/RAB2A/PFKP/RAB11B/PRKAG1/RPS6KB1/PPP2R5B/PPP2CB/ACACB/RAB10/CREB3L2/ADIPOR2/SCD	14
KEGG	hsa00770	Pantothenate and CoA biosynthesis	3/854	21/8135	0.3814	0.8368	0.7398	COASY/ALDH3A2/BCAT1	3
KEGG	hsa05160	Hepatitis C	18/854	157/8135	0.3827	0.8368	0.7398	TYK2/NFKBIA/IFNAR2/CDKN1A/JAK1/TRAF2/RSAD2/CFLAR/MX1/TLR3/STAT3/CLDN1/IRF7/NFKB1/PPP2CB/PPARA/BID/RELA	18
KEGG	hsa05162	Measles	16/854	139/8135	0.3872	0.8368	0.7398	TYK2/MYD88/NFKBIA/IFNAR2/IL12A/JAK1/STAT5A/IFIH1/MX1/CBLB/STAT3/IRF7/NFKB1/CDKN1B/BID/RELA	16
KEGG	hsa00030	Pentose phosphate pathway	4/854	30/8135	0.3879	0.8368	0.7398	PFKP/RBKS/GPI/PGD	4
KEGG	hsa03320	PPAR signaling pathway	9/854	75/8135	0.3885	0.8368	0.7398	FABP5/MMP1/SLC27A1/ACSL4/PLIN2/ACOX2/PPARA/SCD/UBC	9
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	25/854	223/8135	0.3946	0.8368	0.7398	NOX1/NFKBIA/AKR1C1/AKR1A1/NDUFB1/NDUFS3/CYP1B1/NDUFA2/NDUFS1/MAPK14/PLD1/VDAC2/CAT/CYBA/EPHX1/RAC1/ATP5PF/NFKB1/MAP2K4/MAPK11/VDAC1/COX6A1/MGST3/ARNT/RELA	25
KEGG	hsa05205	Proteoglycans in cancer	23/854	205/8135	0.4	0.8368	0.7398	DCN/ITGB1/CTTN/FGF2/ELK1/PPP1R12C/COL1A2/CDKN1A/VAV3/IGF1/MAPK14/FN1/ACTG1/STAT3/RPS6KB1/EIF4B/TIMP3/RAC1/CAMK2D/ACTB/MAPK11/IQGAP1/WNT2	23
KEGG	hsa04012	ErbB signaling pathway	10/854	85/8135	0.4016	0.8368	0.7398	AREG/ELK1/CDKN1A/STAT5A/CBLB/RPS6KB1/PAK4/CAMK2D/CDKN1B/MAP2K4	10
KEGG	hsa04610	Complement and coagulation cascades	10/854	85/8135	0.4016	0.8368	0.7398	C8G/CFB/BDKRB2/C8B/C9/CLU/SERPINE1/MASP2/CFHR3/CFHR4	10
KEGG	hsa05220	Chronic myeloid leukemia	9/854	76/8135	0.404	0.8368	0.7398	NFKBIA/CDKN1A/STAT5A/NFKB1/GADD45B/CDKN1B/BCR/CDKN2A/RELA	9
KEGG	hsa05221	Acute myeloid leukemia	8/854	67/8135	0.4064	0.8368	0.7398	PML/STAT5A/PIM2/RARA/STAT3/RPS6KB1/NFKB1/RELA	8
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	17/854	150/8135	0.407	0.8368	0.7398	ADCY4/ATP2B1/ATF4/TPM4/GNAQ/CALM1/ATP2A2/ADCY6/PLCB1/AGTR1/MAPK14/PPP2R5B/CAMK2D/PPP2CB/ATP2A3/MAPK11/CREB3L2	17
KEGG	hsa00220	Arginine biosynthesis	3/854	22/8135	0.411	0.8368	0.7398	ASS1/GLS/NOS3	3
KEGG	hsa00900	Terpenoid backbone biosynthesis	3/854	22/8135	0.411	0.8368	0.7398	ACAT1/ICMT/MVD	3
KEGG	hsa00260	Glycine, serine and threonine metabolism	5/854	40/8135	0.4121	0.8368	0.7398	GCSH/PSAT1/CTH/SHMT2/GATM	5
KEGG	hsa04670	Leukocyte transendothelial migration	13/854	114/8135	0.4199	0.839	0.7418	ITGB1/CXCL12/VAV3/JAM2/MAPK14/ACTG1/ICAM1/CYBA/RAC1/CLDN1/PECAM1/ACTB/MAPK11	13
KEGG	hsa04330	Notch signaling pathway	7/854	59/8135	0.4264	0.839	0.7418	TLE3/CIR1/TLE4/PSEN1/JAG2/NUMB/DTX3	7
KEGG	hsa04370	VEGF signaling pathway	7/854	59/8135	0.4264	0.839	0.7418	PLA2G4D/MAPK14/PLA2G4C/RAC1/MAPK11/PTGS2/NOS3	7
KEGG	hsa05414	Dilated cardiomyopathy	11/854	96/8135	0.4271	0.839	0.7418	ITGB1/ADCY4/TPM4/ATP2A2/ADCY6/IGF1/ACTG1/ITGA7/ACTB/ATP2A3/EMD	11
KEGG	hsa05219	Bladder cancer	5/854	41/8135	0.4336	0.839	0.7418	CXCL8/MMP1/CDKN1A/TYMP/CDKN2A	5
KEGG	hsa00640	Propanoate metabolism	4/854	32/8135	0.4371	0.839	0.7418	DBT/SUCLA2/SUCLG2/ACACB	4
KEGG	hsa04215	Apoptosis - multiple species	4/854	32/8135	0.4371	0.839	0.7418	PMAIP1/BIRC3/BIRC2/BID	4
KEGG	hsa04924	Renin secretion	8/854	69/8135	0.4395	0.839	0.7418	GNAQ/CALM1/PDE1C/ADCY6/PLCB1/AGTR1/PDE1A/PDE3A	8
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/854	23/8135	0.4401	0.839	0.7418	B4GALT2/CHST10/B4GALT3	3
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/854	14/8135	0.4409	0.839	0.7418	B4GALT2/B4GALT3	2
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	11/854	97/8135	0.4411	0.839	0.7418	CFL2/PLA2G4D/VAV3/ARPC3/MYO10/PLD1/RPS6KB1/PIP5K1A/PLA2G4C/RAC1/LIMK1	11
KEGG	hsa05416	Viral myocarditis	7/854	60/8135	0.4442	0.8402	0.7429	ACTG1/ICAM1/RAC1/ACTB/EIF4G3/BID/HLA-F	7
KEGG	hsa00380	Tryptophan metabolism	5/854	42/8135	0.455	0.8497	0.7512	ACAT1/IL4I1/CYP1B1/ALDH3A2/CAT	5
KEGG	hsa04917	Prolactin signaling pathway	8/854	70/8135	0.456	0.8497	0.7512	STAT5A/SOCS6/MAPK14/SOCS5/STAT3/NFKB1/MAPK11/RELA	8
KEGG	hsa00051	Fructose and mannose metabolism	4/854	33/8135	0.4613	0.8497	0.7512	GMPPA/PFKP/GMDS/GMPPB	4
KEGG	hsa05016	Huntington disease	33/854	306/8135	0.4623	0.8497	0.7512	POLR2A/GPX8/GPX3/CLTC/GNAQ/NDUFB1/TRAF2/SP1/PSMA1/NDUFS3/PLCB1/ERN1/POLR2K/TUBB/NRF1/NDUFA2/ACTR1B/NDUFS1/PSMA6/DNAH10/VDAC2/ATG2A/CLTCL1/ATP5PF/KLC2/TUBB4B/DCTN5/VDAC1/COX6A1/DNAH1/CREB3L2/WIPI1/DNAH17	33
KEGG	hsa04151	PI3K-Akt signaling pathway	38/854	354/8135	0.4677	0.8497	0.7512	CSF3/AREG/ITGB1/ATF4/FGF7/HSP90B1/GNB3/IFNAR2/FGF2/COL1A2/CRTC2/CDKN1A/JAK1/DDIT4/IL4R/IGF1/PDGFRA/SGK1/LAMB1/FN1/COL9A2/FGFR4/RPS6KB1/EIF4B/OSMR/THBS2/RAC1/IL7/ITGA7/PPP2R5B/NFKB1/CDKN1B/PPP2CB/CREB3L2/LAMA3/NOS3/RELA/PDGFA	38
KEGG	hsa04977	Vitamin digestion and absorption	3/854	24/8135	0.4687	0.8497	0.7512	LMBRD1/SLC19A3/SLC5A6	3
KEGG	hsa04520	Adherens junction	8/854	71/8135	0.4724	0.8497	0.7512	FER/ACTG1/TJP1/NECTIN2/RAC1/ACTB/BAIAP2/IQGAP1	8
KEGG	hsa05410	Hypertrophic cardiomyopathy	10/854	90/8135	0.4749	0.8497	0.7512	ITGB1/TPM4/ATP2A2/IGF1/ACTG1/PRKAG1/ITGA7/ACTB/ATP2A3/EMD	10
KEGG	hsa04714	Thermogenesis	25/854	232/8135	0.4766	0.8497	0.7512	ADCY4/ACTL6A/RPS6KA3/NDUFB1/COA1/ACSL4/SMARCA2/ADCY6/NDUFS3/SMARCC1/NDUFA2/NDUFS1/MAP2K3/MAPK14/ACTG1/PRKAG1/RPS6KB1/ATP5PF/ACTB/SMARCE1/MAPK11/COX6A1/CREB3L2/COX17/ATP5MF	25
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/854	15/8135	0.4774	0.8497	0.7512	ST8SIA5/ST6GALNAC4	2
KEGG	hsa04213	Longevity regulating pathway - multiple species	7/854	62/8135	0.4795	0.8497	0.7512	ADCY4/ADCY6/IGF1/PRKAG1/RPS6KB1/CAT/ATG5	7
KEGG	hsa05203	Viral carcinogenesis	22/854	204/8135	0.4806	0.8497	0.7512	PMAIP1/ATF4/NFKBIA/GTF2B/CDKN1A/JAK1/TRAF5/TRAF2/STAT5A/DLG1/STAT3/SP100/RAC1/IRF7/NFKB1/ATP6V0D1/CDKN1B/HDAC7/CDKN2A/CREB3L2/RELA/HLA-F	22
KEGG	hsa04935	Growth hormone synthesis, secretion and action	13/854	119/8135	0.4836	0.8497	0.7512	ADCY4/ATF4/GNAQ/ADCY6/STAT5A/PLCB1/IGF1/MAP2K3/MAPK14/STAT3/MAP2K4/MAPK11/CREB3L2	13
KEGG	hsa03020	RNA polymerase	4/854	34/8135	0.4852	0.8497	0.7512	POLR2A/POLR3H/POLR2K/POLR3B	4
KEGG	hsa00562	Inositol phosphate metabolism	8/854	73/8135	0.5049	0.8729	0.7718	PLCB1/IMPA1/PLCD4/INPP5K/PIP5K1A/IPPK/INPP1/SYNJ2	8
KEGG	hsa01524	Platinum drug resistance	8/854	73/8135	0.5049	0.8729	0.7718	PMAIP1/CDKN1A/BIRC3/BIRC2/MLH1/CDKN2A/MGST3/BID	8
KEGG	hsa03460	Fanconi anemia pathway	6/854	54/8135	0.5064	0.8729	0.7718	BRCA2/MLH1/REV1/WDR48/FANCM/RPA3	6
KEGG	hsa04972	Pancreatic secretion	11/854	102/8135	0.5101	0.8748	0.7734	ADCY4/RAB27B/ATP2B1/GNAQ/ATP2A2/ADCY6/PLCB1/TRPC1/RAC1/SLC12A2/ATP2A3	11
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/854	26/8135	0.5237	0.884	0.7816	PGAP1/PIGK/PIGO	3
KEGG	hsa00790	Folate biosynthesis	3/854	26/8135	0.5237	0.884	0.7816	GCH1/DHFR2/PTS	3
KEGG	hsa04142	Lysosome	14/854	132/8135	0.5262	0.884	0.7816	LGMN/CLTC/ATP6AP1/AP3S1/AP1M1/GGA2/AP4M1/GGA3/SLC17A5/CLTCL1/AP1S2/ATP6V0D1/SMPD1/AP3S2	14
KEGG	hsa04728	Dopaminergic synapse	14/854	132/8135	0.5262	0.884	0.7816	ATF4/GNAQ/GNB3/CALM1/PLCB1/MAPK14/GNAL/PPP2R5B/CAMK2D/PPP2CB/MAPK11/ARRB1/CREB3L2/SLC6A3	14
KEGG	hsa05214	Glioma	8/854	75/8135	0.5367	0.8972	0.7932	CALM1/CDKN1A/IGF1/PDGFRA/CAMK2D/GADD45B/CDKN2A/PDGFA	8
KEGG	hsa04724	Glutamatergic synapse	12/854	114/8135	0.5416	0.9005	0.7961	ADCY4/GNAQ/GNB3/SLC38A2/PLA2G4D/ADCY6/PLCB1/TRPC1/SLC38A1/PLD1/GLS/PLA2G4C	12
KEGG	hsa04510	Focal adhesion	21/854	201/8135	0.5442	0.9005	0.7961	ITGB1/ELK1/PPP1R12C/COL1A2/BIRC3/VAV3/IGF1/PDGFRA/BIRC2/LAMB1/FN1/ACTG1/COL9A2/THBS2/PIP5K1A/RAC1/PAK4/ITGA7/ACTB/LAMA3/PDGFA	21
KEGG	hsa00062	Fatty acid elongation	3/854	27/8135	0.55	0.9005	0.7961	ACAA2/ACOT2/MECR	3
KEGG	hsa04966	Collecting duct acid secretion	3/854	27/8135	0.55	0.9005	0.7961	SLC12A7/ATP6V1E1/ATP6V0D1	3
KEGG	hsa04971	Gastric acid secretion	8/854	76/8135	0.5523	0.9005	0.7961	ADCY4/GNAQ/CALM1/ADCY6/PLCB1/ACTG1/CAMK2D/ACTB	8
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	11/854	106/8135	0.5635	0.9114	0.8057	ADCY4/ATF4/GNAQ/CDKN1A/SP1/ADCY6/PLCB1/CYP24A1/PLD1/ARRB1/CREB3L2	11
KEGG	hsa00010	Glycolysis / Gluconeogenesis	7/854	67/8135	0.5644	0.9114	0.8057	AKR1A1/PFKP/ALDH3A2/ENO2/GPI/ADH5/PDHB	7
KEGG	hsa04934	Cushing syndrome	16/854	155/8135	0.5681	0.9128	0.807	ADCY4/ATF4/GNAQ/CDKN1A/FH/SP1/ADCY6/PLCB1/AGTR1/CAMK2D/RBBP5/CDKN1B/CDKN2A/CREB3L2/ARNT/WNT2	16
KEGG	hsa04612	Antigen processing and presentation	8/854	78/8135	0.5828	0.9319	0.8239	RFX5/LGMN/RFXAP/PSME2/PDIA3/CALR/CANX/HLA-F	8
KEGG	hsa04925	Aldosterone synthesis and secretion	10/854	98/8135	0.5872	0.9344	0.8261	ADCY4/ATP2B1/ATF4/GNAQ/CALM1/ADCY6/PLCB1/AGTR1/CAMK2D/CREB3L2	10
KEGG	hsa05030	Cocaine addiction	5/854	49/8135	0.5958	0.9436	0.8342	ATF4/NFKB1/CREB3L2/SLC6A3/RELA	5
KEGG	hsa04530	Tight junction	17/854	169/8135	0.6123	0.9545	0.8439	ITGB1/CTTN/DLG1/RAB13/ARPC3/MICALL2/JAM2/ACTG1/PRKAG1/TJP1/MYH14/RAC1/CLDN1/ACTB/PPP2CB/DLG3/AMOTL1	17
KEGG	hsa04730	Long-term depression	6/854	60/8135	0.6128	0.9545	0.8439	GNAQ/PLA2G4D/PLCB1/IGF1/PLA2G4C/PPP2CB	6
KEGG	hsa04978	Mineral absorption	6/854	60/8135	0.6128	0.9545	0.8439	MT2A/FTH1/ATP2B1/SLC30A1/SLC9A3/CYBRD1	6
KEGG	hsa05010	Alzheimer disease	39/854	384/8135	0.6142	0.9545	0.8439	NOX1/ATF4/APBB1/MCU/GNAQ/CALM1/NDUFB1/TRAF2/ATP2A2/PSMA1/NDUFS3/PLCB1/ERN1/TUBB/HSD17B10/ATF6/NDUFA2/PSEN1/SLC39A9/NDUFS1/PSMA6/RTN4/NAE1/VDAC2/ATG2A/ATP5PF/RTN3/KLC2/NFKB1/TUBB4B/ATP2A3/VDAC1/COX6A1/PTGS2/SLC39A14/BID/RELA/WIPI1/WNT2	39
KEGG	hsa04916	Melanogenesis	10/854	101/8135	0.6264	0.9642	0.8524	ADCY4/GNAQ/CALM1/ASIP/MITF/ADCY6/PLCB1/CAMK2D/CREB3L2/WNT2	10
KEGG	hsa04140	Autophagy - animal	14/854	141/8135	0.629	0.9642	0.8524	DDIT4/RUBCN/ATG4B/CFLAR/ERN1/RPS6KB1/STX17/RAB1A/ATG16L1/ATG2A/TANK/PPP2CB/ATG5/WIPI1	14
KEGG	hsa00590	Arachidonic acid metabolism	6/854	61/8135	0.6292	0.9642	0.8524	GPX8/GPX3/PLA2G4D/PRXL2B/PLA2G4C/PTGS2	6
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	21/854	212/8135	0.6459	0.9764	0.8632	CDC6/ADCY4/ATF4/FGF7/HSP90B1/RPS6KA3/FGF2/ADCY6/STAT5A/CYP1B1/STAT3/RPS6KB1/KPNB1/EPHX1/NFKB1/PPARA/ARRB1/CREB3L2/MGST3/ARNT/RELA	21
KEGG	hsa00052	Galactose metabolism	3/854	31/8135	0.646	0.9764	0.8632	B4GALT2/PFKP/GALE	3
KEGG	hsa04710	Circadian rhythm	3/854	31/8135	0.646	0.9764	0.8632	PER3/PRKAG1/CRY2	3
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/854	143/8135	0.6504	0.978	0.8646	FGF2/RIF1/JAK1/IGF1/ID3/MAPK14/STAT3/FGFR4/SMARCAD1/PCGF1/MAPK11/BMPR1A/ACVR2A/WNT2	14
KEGG	hsa05202	Transcriptional misregulation in cancer	19/854	193/8135	0.653	0.978	0.8646	CXCL8/MLLT3/CDKN1A/MITF/SP1/PML/BIRC3/MMP3/IGF1/BIRC2/RARA/BMP2K/HMGA2/NFKB1/GADD45B/CDKN1B/NR4A3/RELA/PDGFA	19
KEGG	hsa04660	T cell receptor signaling pathway	10/854	104/8135	0.6637	0.9895	0.8748	NFKBIA/DLG1/VAV3/CBLB/MAPK14/IL10/PAK4/NFKB1/MAPK11/RELA	10
KEGG	hsa04940	Type I diabetes mellitus	4/854	43/8135	0.6749	1	0.8841	IL12A/PTPRN/HSPD1/HLA-F	4
KEGG	hsa05012	Parkinson disease	26/854	266/8135	0.6821	1	0.8841	ATF4/ADORA2A/MCU/CALM1/NDUFB1/PSMA1/NDUFS3/ERN1/TUBB/ATF6/NDUFA2/SLC39A9/NDUFS1/PSMA6/GNAL/VDAC2/ATP5PF/DAXX/CAMK2D/KLC2/TUBB4B/VDAC1/COX6A1/SLC6A3/SLC39A14/UBC	26
KEGG	hsa04022	cGMP-PKG signaling pathway	16/854	167/8135	0.6893	1	0.8841	ADCY4/ATP2B1/ATF4/GNAQ/CALM1/ATP2A2/BDKRB2/ADCY6/PLCB1/AGTR1/VDAC2/ATP2A3/VDAC1/CREB3L2/NOS3/PDE3A	16
KEGG	hsa05210	Colorectal cancer	8/854	86/8135	0.6938	1	0.8841	AREG/PMAIP1/CDKN1A/APPL1/MLH1/RPS6KB1/RAC1/GADD45B	8
KEGG	hsa04915	Estrogen signaling pathway	13/854	138/8135	0.7023	1	0.8841	ADCY4/ATF4/HSP90B1/GNAQ/CALM1/SP1/ADCY6/PLCB1/RARA/NCOA1/CREB3L2/NOS3/FKBP5	13
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/854	11/8135	0.705	1	0.8841	COQ7	1
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/854	77/8135	0.7117	1	0.8841	ITGB1/ATP2A2/ACTG1/ITGA7/ACTB/ATP2A3/EMD	7
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/854	23/8135	0.7119	1	0.8841	SLC9A3/GLS	2
KEGG	hsa00564	Glycerophospholipid metabolism	9/854	98/8135	0.7136	1	0.8841	LPCAT2/PEMT/LPCAT4/PLA2G4D/GPAT4/PLD1/LPCAT3/PLA2G4C/PLD3	9
KEGG	hsa05231	Choline metabolism in cancer	9/854	98/8135	0.7136	1	0.8841	PLA2G4D/SP1/PDGFRA/PLD1/RPS6KB1/PIP5K1A/PLA2G4C/RAC1/PDGFA	9
KEGG	hsa04720	Long-term potentiation	6/854	67/8135	0.7189	1	0.8841	ATF4/GNAQ/RPS6KA3/CALM1/PLCB1/CAMK2D	6
KEGG	hsa04721	Synaptic vesicle cycle	7/854	78/8135	0.7244	1	0.8841	CLTC/UNC13A/CLTCL1/ATP6V1E1/ATP6V0D1/SLC6A9/SLC6A3	7
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/854	24/8135	0.7341	1	0.8841	EXTL2/NDST1	2
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/854	79/8135	0.7368	1	0.8841	FGF2/JAK1/IGF1/PDGFRA/STAT3/RPS6KB1/PDGFA	7
KEGG	hsa00350	Tyrosine metabolism	3/854	36/8135	0.7444	1	0.8841	GSTZ1/IL4I1/ADH5	3
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	3/854	36/8135	0.7444	1	0.8841	NAMPT/NNMT/SIRT5	3
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	6/854	69/8135	0.7452	1	0.8841	CYP1B1/EPHX1/SULT1A3/SULT1A4/MGST3/PTGS2	6
KEGG	hsa05211	Renal cell carcinoma	6/854	69/8135	0.7452	1	0.8841	CDKN1A/FH/RAC1/PAK4/VHL/ARNT	6
KEGG	hsa00592	alpha-Linolenic acid metabolism	2/854	25/8135	0.7547	1	0.8841	PLA2G4D/PLA2G4C	2
KEGG	hsa05230	Central carbon metabolism in cancer	6/854	70/8135	0.7577	1	0.8841	IDH1/PDGFRA/PFKP/GLS/PDHB/SLC16A3	6
KEGG	hsa05216	Thyroid cancer	3/854	37/8135	0.7612	1	0.8841	CDKN1A/CCDC6/GADD45B	3
KEGG	hsa00190	Oxidative phosphorylation	12/854	134/8135	0.7619	1	0.8841	ATP6AP1/NDUFB1/NDUFS3/NDUFA2/NDUFS1/PPA2/ATP6V1E1/ATP5PF/ATP6V0D1/COX6A1/COX17/ATP5MF	12
KEGG	hsa03450	Non-homologous end-joining	1/854	13/8135	0.7638	1	0.8841	RAD50	1
KEGG	hsa04146	Peroxisome	7/854	82/8135	0.7714	1	0.8841	HSD17B4/ACSL4/IDH1/MPV17L/BAAT/CAT/ACOX2	7
KEGG	hsa04150	mTOR signaling pathway	14/854	156/8135	0.7717	1	0.8841	SEC13/RPS6KA3/DDIT4/IGF1/SGK1/RNF152/RPS6KB1/EIF4B/ATP6V1E1/RICTOR/NPRL3/LAMTOR3/WNT2/SLC3A2	14
KEGG	hsa04970	Salivary secretion	8/854	93/8135	0.7739	1	0.8841	ADCY4/ATP2B1/GNAQ/CALM1/ADCY6/PLCB1/SLC12A2/CST3	8
KEGG	hsa05330	Allograft rejection	3/854	38/8135	0.7771	1	0.8841	IL12A/IL10/HLA-F	3
KEGG	hsa05223	Non-small cell lung cancer	6/854	72/8135	0.7812	1	0.8841	CDKN1A/STK4/STAT5A/STAT3/GADD45B/CDKN2A	6
KEGG	hsa04979	Cholesterol metabolism	4/854	50/8135	0.7847	1	0.8841	VAPA/LDLRAP1/VDAC2/VDAC1	4
KEGG	hsa04072	Phospholipase D signaling pathway	13/854	148/8135	0.7913	1	0.8841	CXCL8/ADCY4/PLA2G4D/ADCY6/PLCB1/PDGFRA/AGTR1/PLD1/PIP5K1A/PLA2G4C/MS4A2/CYTH1/PDGFA	13
KEGG	hsa04723	Retrograde endocannabinoid signaling	13/854	148/8135	0.7913	1	0.8841	ADCY4/GNAQ/GNB3/NDUFB1/ADCY6/NDUFS3/PLCB1/GABRE/NDUFA2/NDUFS1/MAPK14/MAPK11/PTGS2	13
KEGG	hsa04371	Apelin signaling pathway	12/854	139/8135	0.8036	1	0.8841	ADCY4/GNAQ/GNB3/CALM1/ADCY6/PLCB1/NRF1/AGTR1/SERPINE1/PRKAG1/RPS6KB1/NOS3	12
KEGG	hsa00310	Lysine degradation	5/854	63/8135	0.8052	1	0.8841	ACAT1/PHYKPL/ALDH3A2/EZH2/SUV39H1	5
KEGG	hsa00650	Butanoate metabolism	2/854	28/8135	0.8085	1	0.8841	ACAT1/BDH2	2
KEGG	hsa04360	Axon guidance	16/854	182/8135	0.8094	1	0.8841	ITGB1/CFL2/CXCL12/SSH2/RND1/ENAH/UNC5B/TRPC1/DPYSL2/RAC1/PAK4/UNC5D/CAMK2D/LIMK1/SEMA7A/EFNB1	16
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/854	15/8135	0.8108	1	0.8841	A4GALT	1
KEGG	hsa04911	Insulin secretion	7/854	86/8135	0.8122	1	0.8841	ADCY4/ATF4/GNAQ/ADCY6/PLCB1/CAMK2D/CREB3L2	7
KEGG	hsa04070	Phosphatidylinositol signaling system	8/854	97/8135	0.8123	1	0.8841	CALM1/PLCB1/IMPA1/PLCD4/PIP5K1A/IPPK/INPP1/SYNJ2	8
KEGG	hsa04713	Circadian entrainment	8/854	97/8135	0.8123	1	0.8841	ADCY4/GNAQ/GNB3/CALM1/ADCY6/PLCB1/PER3/CAMK2D	8
KEGG	hsa04929	GnRH secretion	5/854	64/8135	0.8161	1	0.8841	GNAQ/PLCB1/TRPC1/ARRB1/HCN2	5
KEGG	hsa00591	Linoleic acid metabolism	2/854	29/8135	0.824	1	0.8841	PLA2G4D/PLA2G4C	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/854	29/8135	0.824	1	0.8841	MOB1A/SAV1	2
KEGG	hsa00360	Phenylalanine metabolism	1/854	16/8135	0.8307	1	0.8841	IL4I1	1
KEGG	hsa05165	Human papillomavirus infection	30/854	331/8135	0.8314	1	0.8841	ITGB1/TYK2/ATP6AP1/IFNAR2/COL1A2/CDKN1A/JAK1/DLG1/MX1/PSEN1/LAMB1/TLR3/FN1/COL9A2/RPS6KB1/THBS2/ATP6V1E1/ITGA7/PPP2R5B/NFKB1/ATP6V0D1/CDKN1B/PPP2CB/CREB3L2/PTGS2/LAMA3/DLG3/RELA/WNT2/HLA-F	30
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/854	30/8135	0.8383	1	0.8841	AKR1A1/ALDH3A2	2
KEGG	hsa04727	GABAergic synapse	7/854	89/8135	0.839	1	0.8841	ADCY4/GNB3/SLC38A2/ADCY6/GABRE/SLC38A1/GLS	7
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/854	78/8135	0.8415	1	0.8841	CYP2D7/AKR1C1/CYP1B1/EPHX1/ADH5/MGST3	6
KEGG	hsa00860	Porphyrin metabolism	3/854	43/8135	0.844	1	0.8841	HMBS/CPOX/CP	3
KEGG	hsa04270	Vascular smooth muscle contraction	11/854	134/8135	0.8454	1	0.8841	ADCY4/ADORA2A/GNAQ/PPP1R12C/CALM1/PLA2G4D/ADCY6/PLCB1/AGTR1/MYH14/PLA2G4C	11
KEGG	hsa00910	Nitrogen metabolism	1/854	17/8135	0.8485	1	0.8841	CA3	1
KEGG	hsa05310	Asthma	2/854	31/8135	0.8516	1	0.8841	IL10/MS4A2	2
KEGG	hsa04725	Cholinergic synapse	9/854	113/8135	0.852	1	0.8841	ADCY4/ATF4/GNAQ/GNB3/ADCY6/PLCB1/KCNJ12/CAMK2D/CREB3L2	9
KEGG	hsa04024	cAMP signaling pathway	19/854	221/8135	0.8531	1	0.8841	ADCY4/ATP2B1/PDE10A/ADORA2A/NFKBIA/CALM1/ATP2A2/ADCY6/VAV3/PLD1/RAC1/CAMK2D/NFKB1/ATP2A3/PPARA/CREB3L2/RELA/PDE3A/HCN2	19
KEGG	hsa04390	Hippo signaling pathway	13/854	157/8135	0.8536	1	0.8841	AREG/BIRC3/DLG1/BIRC2/SERPINE1/ACTG1/ACTB/PPP2CB/BMPR1A/MOB1A/DLG3/SAV1/WNT2	13
KEGG	hsa05225	Hepatocellular carcinoma	14/854	168/8135	0.8549	1	0.8841	ACTL6A/ELK1/TXNRD3/CDKN1A/SMARCA2/SMARCC1/ACTG1/RPS6KB1/ACTB/GADD45B/SMARCE1/CDKN2A/MGST3/WNT2	14
KEGG	hsa05031	Amphetamine addiction	5/854	69/8135	0.8636	1	0.8841	ATF4/CALM1/CAMK2D/CREB3L2/SLC6A3	5
KEGG	hsa00511	Other glycan degradation	1/854	18/8135	0.8645	1	0.8841	ENGASE	1
KEGG	hsa02010	ABC transporters	3/854	45/8135	0.8654	1	0.8841	ABCA5/ABCA7/ABCA10	3
KEGG	hsa03022	Basal transcription factors	3/854	45/8135	0.8654	1	0.8841	GTF2B/TAF7/CDK7	3
KEGG	hsa04726	Serotonergic synapse	9/854	115/8135	0.8657	1	0.8841	CYP2D7/GNAQ/GNB3/PLA2G4D/PLCB1/TRPC1/HTR2A/PLA2G4C/PTGS2	9
KEGG	hsa05213	Endometrial cancer	4/854	58/8135	0.8717	1	0.8841	ELK1/CDKN1A/MLH1/GADD45B	4
KEGG	hsa04662	B cell receptor signaling pathway	6/854	82/8135	0.8737	1	0.8841	NFKBIA/VAV3/RAC1/NFKB1/CD72/RELA	6
KEGG	hsa03050	Proteasome	3/854	46/8135	0.8751	1	0.8841	PSMA1/PSME2/PSMA6	3
KEGG	hsa00040	Pentose and glucuronate interconversions	2/854	34/8135	0.8856	1	0.8841	AKR1A1/DCXR	2
KEGG	hsa00982	Drug metabolism - cytochrome P450	5/854	72/8135	0.8868	1	0.8841	CYP2D7/FMO5/FMO3/ADH5/MGST3	5
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/854	20/8135	0.8915	1	0.8841	DSE	1
KEGG	hsa05020	Prion disease	23/854	273/8135	0.8948	1	0.8841	ATF4/MCU/C8G/NDUFB1/PSMA1/NDUFS3/C8B/TUBB/C9/NDUFA2/NDUFS1/PSMA6/MAPK14/VDAC2/CYBA/RAC1/ATP5PF/KLC2/TUBB4B/MAPK11/VDAC1/COX6A1/CREB3L2	23
KEGG	hsa04742	Taste transduction	6/854	86/8135	0.9002	1	0.8841	ADCY4/GNB3/PDE1C/ADCY6/PLCB1/PDE1A	6
KEGG	hsa04919	Thyroid hormone signaling pathway	9/854	121/8135	0.9005	1	0.8841	ATP2A2/PLCB1/PLCD4/PFKP/ACTG1/TBC1D4/ACTB/NCOA1/ATP2A3	9
KEGG	hsa04672	Intestinal immune network for IgA production	3/854	49/8135	0.9007	1	0.8841	CXCL12/TNFSF13B/IL10	3
KEGG	hsa04014	Ras signaling pathway	19/854	232/8135	0.9019	1	0.8841	RAB5A/FGF7/GNB3/FGF2/ELK1/CALM1/STK4/PLA2G4D/RIN1/IGF1/PDGFRA/PLD1/FGFR4/PLA2G4C/RAC1/PAK4/NFKB1/RELA/PDGFA	19
KEGG	hsa00500	Starch and sucrose metabolism	2/854	36/8135	0.9041	1	0.8841	GBE1/GPI	2
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	2/854	37/8135	0.9123	1	0.8841	IGF1/SGK1	2
KEGG	hsa00340	Histidine metabolism	1/854	22/8135	0.9131	1	0.8841	ALDH3A2	1
KEGG	hsa05224	Breast cancer	11/854	147/8135	0.9152	1	0.8841	FGF7/FGF2/CDKN1A/BRCA2/SP1/IGF1/JAG2/RPS6KB1/GADD45B/NCOA1/WNT2	11
KEGG	hsa04976	Bile secretion	6/854	89/8135	0.9168	1	0.8841	ADCY4/ADCY6/SLC9A3/BAAT/EPHX1/SLC4A5	6
KEGG	hsa05340	Primary immunodeficiency	2/854	38/8135	0.9198	1	0.8841	RFX5/RFXAP	2
KEGG	hsa00600	Sphingolipid metabolism	3/854	52/8135	0.9214	1	0.8841	SPTLC3/SMPD3/SMPD1	3
KEGG	hsa04614	Renin-angiotensin system	1/854	23/8135	0.9223	1	0.8841	AGTR1	1
KEGG	hsa04340	Hedgehog signaling pathway	3/854	56/8135	0.9429	1	0.8841	MGRN1/SMURF1/ARRB1	3
KEGG	hsa04923	Regulation of lipolysis in adipocytes	3/854	56/8135	0.9429	1	0.8841	ADCY4/ADCY6/PTGS2	3
KEGG	hsa04975	Fat digestion and absorption	2/854	43/8135	0.9491	1	0.8841	SLC27A1/ACAT1	2
KEGG	hsa03010	Ribosome	11/854	158/8135	0.9515	1	0.8841	MRPL35/MRPL9/MRPL3/RPL13/MRPL27/RPL13A/MRPL33/RPS3/RPL38/MRPS7/RPL24	11
KEGG	hsa04640	Hematopoietic cell lineage	6/854	99/8135	0.9561	1	0.8841	CSF3/IL1R1/GP1BB/IL4R/IL11RA/IL7	6
KEGG	hsa04514	Cell adhesion molecules	10/854	149/8135	0.9585	1	0.8841	ITGB1/CD274/JAM2/NLGN2/VCAN/ICAM1/NECTIN2/CLDN1/PECAM1/HLA-F	10
KEGG	hsa04744	Phototransduction	1/854	29/8135	0.9601	1	0.8841	CALM1	1
KEGG	hsa00140	Steroid hormone biosynthesis	3/854	61/8135	0.9621	1	0.8841	AKR1C1/SRD5A1/CYP1B1	3
KEGG	hsa00561	Glycerolipid metabolism	3/854	61/8135	0.9621	1	0.8841	AKR1A1/GPAT4/ALDH3A2	3
KEGG	hsa04974	Protein digestion and absorption	6/854	103/8135	0.9664	1	0.8841	COL1A2/SLC38A2/SLC9A3/COL9A2/SLC36A4/SLC3A2	6
KEGG	hsa05217	Basal cell carcinoma	3/854	63/8135	0.9679	1	0.8841	CDKN1A/GADD45B/WNT2	3
KEGG	hsa00410	beta-Alanine metabolism	1/854	31/8135	0.9681	1	0.8841	ALDH3A2	1
KEGG	hsa04310	Wnt signaling pathway	11/854	167/8135	0.9703	1	0.8841	TLE3/SFRP1/RSPO3/CCN4/PLCB1/TLE4/PSEN1/RAC1/CAMK2D/DAAM1/WNT2	11
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	8/854	131/8135	0.9716	1	0.8841	IFNGR2/TNFRSF10B/IFNAR2/VAV3/ICAM1/RAC1/MICA/BID	8
KEGG	hsa05150	Staphylococcus aureus infection	5/854	96/8135	0.9784	1	0.8841	CFB/ICAM1/IL10/MASP2/FCAR	5
KEGG	hsa05320	Autoimmune thyroid disease	2/854	53/8135	0.9801	1	0.8841	IL10/HLA-F	2
KEGG	hsa04910	Insulin signaling pathway	8/854	137/8135	0.9806	1	0.8841	ELK1/CALM1/CBLB/PRKAG1/RPS6KB1/PHKB/ACACB/PPP1R3E	8
KEGG	hsa04613	Neutrophil extracellular trap formation	12/854	190/8135	0.9839	1	0.8841	PLCB1/MAPK14/ACTG1/VDAC2/CYBA/RAC1/NFKB1/ACTB/MAPK11/VDAC1/HDAC7/RELA	12
KEGG	hsa04260	Cardiac muscle contraction	4/854	87/8135	0.9853	1	0.8841	TPM4/ATP2A2/ATP2A3/COX6A1	4
KEGG	hsa05206	MicroRNAs in cancer	22/854	310/8135	0.9854	1	0.8841	SOX4/CDKN1A/DDIT4/PDGFRA/CYP24A1/CYP1B1/KIF23/CCNG1/STAT3/GLS/TIMP3/EZH2/HMGA2/PAK4/DNMT3B/NFKB1/CDKN1B/CDKN2A/PTGS2/PDGFA/BCL2L2/MAPK7	22
KEGG	hsa05033	Nicotine addiction	1/854	40/8135	0.9883	1	0.8841	GABRE	1
KEGG	hsa05332	Graft-versus-host disease	1/854	42/8135	0.9906	1	0.8841	HLA-F	1
KEGG	hsa05226	Gastric cancer	8/854	149/8135	0.9912	1	0.8841	FGF7/FGF2/CDKN1A/MLH1/RPS6KB1/GADD45B/CDKN1B/WNT2	8
KEGG	hsa05322	Systemic lupus erythematosus	7/854	136/8135	0.9915	1	0.8841	TRIM21/C8G/C8B/C9/RO60/SNRPD1/IL10	7
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	2/854	66/8135	0.9943	1	0.8841	CARS2/SEPSECS	2
KEGG	hsa04973	Carbohydrate digestion and absorption	1/854	47/8135	0.9946	1	0.8841	PLCB1	1
KEGG	hsa05034	Alcoholism	8/854	187/8135	0.9994	1	0.8841	ATF4/ADORA2A/GNB3/CALM1/CAMKK1/HDAC7/CREB3L2/SLC6A3	8
KEGG	hsa00830	Retinol metabolism	1/854	68/8135	0.9995	1	0.8841	ADH5	1
KEGG	hsa04080	Neuroactive ligand-receptor interaction	8/854	353/8135	1	1	0.8841	ADORA2A/BDKRB2/GABRE/AGTR1/P2RX1/HTR2A/HRH1/UTS2B	8
KEGG	hsa04740	Olfactory transduction	7/854	440/8135	1	1	0.8841	CALM1/PDE1C/GNAL/CAMK2D/PDE1A/OR5F1/ARRB1	7