ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04350	TGF-beta signaling pathway	13/481	94/8135	0.003388	0.7493	0.7493	BMP6/ACVR2A/AMH/CHRD/MAPK1/TFDP1/RBX1/FBN1/TGFBR2/THBS1/BMP8A/FST/INHBC	13
KEGG	hsa05220	Chronic myeloid leukemia	11/481	76/8135	0.004788	0.7493	0.7493	CDKN1A/CDKN2A/MAPK1/SOS1/TGFBR2/CTBP1/CHUK/HRAS/PTPN11/STAT5B/BCL2L1	11
KEGG	hsa04380	Osteoclast differentiation	14/481	128/8135	0.01866	0.8519	0.8519	SOCS3/NFATC2/LCK/FCGR2A/MAPK1/SIRPB1/SQSTM1/FCGR2B/TREM2/CTSK/TGFBR2/CHUK/LILRA1/IFNAR2	14
KEGG	hsa03420	Nucleotide excision repair	7/481	47/8135	0.01945	0.8519	0.8519	XPA/POLE2/ERCC1/LIG1/POLD1/RBX1/RPA3	7
KEGG	hsa05211	Renal cell carcinoma	9/481	69/8135	0.01964	0.8519	0.8519	CDKN1A/MAPK1/PAK4/SOS1/RBX1/TGFA/TFE3/HRAS/PTPN11	9
KEGG	hsa04120	Ubiquitin mediated proteolysis	15/481	142/8135	0.02034	0.8519	0.8519	PRKN/SOCS3/WWP2/UBB/UBE2L6/UBE2R2/UBE2D4/UBE2F/ANAPC15/PRPF19/RBX1/RHOBTB2/TRIP12/HERC1/UBE4B	15
KEGG	hsa05223	Non-small cell lung cancer	9/481	72/8135	0.02526	0.8519	0.8519	CDKN1A/CDKN2A/MAPK1/STAT3/SOS1/TGFA/JAK3/HRAS/STAT5B	9
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/481	20/8135	0.02745	0.8519	0.8519	CHST12/B4GALT7/XYLT2/CSGALNACT1	4
KEGG	hsa05212	Pancreatic cancer	9/481	76/8135	0.03442	0.8519	0.8519	CDKN1A/CDKN2A/MAPK1/STAT3/TGFBR2/TGFA/CHUK/RALA/BCL2L1	9
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	20/481	222/8135	0.03897	0.8519	0.8519	CDKN1A/NFATC2/LCK/B2M/CDKN2A/MAPK1/GPS2/TNFRSF13C/ANAPC15/PTEN/TGFBR2/CHUK/ADCY1/JAK3/HRAS/STAT5B/MAP3K3/BCL2L1/TLN1/HLA-A	20
KEGG	hsa03060	Protein export	4/481	23/8135	0.04367	0.8519	0.8519	SRPRA/SRP14/OXA1L/SEC61A2	4
KEGG	hsa03430	Mismatch repair	4/481	23/8135	0.04367	0.8519	0.8519	LIG1/POLD1/MLH3/RPA3	4
KEGG	hsa05160	Hepatitis C	15/481	157/8135	0.04441	0.8519	0.8519	SOCS3/TRADD/RIPK1/CDKN1A/CLDN34/YWHAE/CLDN15/MAPK1/STAT3/SOS1/YWHAQ/CHUK/HRAS/PPP2R2B/IFNAR2	15
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	13/481	131/8135	0.04557	0.8519	0.8519	KIR3DL3/KLRC3/NFATC2/LCK/MAPK1/SOS1/KIR2DS4/HRAS/PTPN11/KIR3DL1/VAV2/IFNAR2/HLA-A	13
KEGG	hsa04920	Adipocytokine signaling pathway	8/481	69/8135	0.0497	0.8519	0.8519	SOCS3/TRADD/STAT3/CHUK/ADIPOQ/PTPN11/ADIPOR1/ACSBG1	8
KEGG	hsa04662	B cell receptor signaling pathway	9/481	82/8135	0.05208	0.8519	0.8519	NFATC2/CD72/MAPK1/FCGR2B/SOS1/CHUK/HRAS/LILRA1/VAV2	9
KEGG	hsa04917	Prolactin signaling pathway	8/481	70/8135	0.05335	0.8519	0.8519	SOCS3/GALT/MAPK1/STAT3/SOS1/HRAS/STAT5B/TH	8
KEGG	hsa04072	Phospholipase D signaling pathway	14/481	148/8135	0.05456	0.8519	0.8519	SPHK2/RHEB/AVP/MAPK1/SOS1/ADCY1/DGKA/AGPAT1/DGKB/HRAS/RALA/GRM6/PTPN11/F2	14
KEGG	hsa04330	Notch signaling pathway	7/481	59/8135	0.05789	0.8519	0.8519	HEY1/NOTCH1/TLE1/CIR1/CTBP1/DTX3/MAML3	7
KEGG	hsa03030	DNA replication	5/481	36/8135	0.05876	0.8519	0.8519	MCM2/POLE2/LIG1/POLD1/RPA3	5
KEGG	hsa04137	Mitophagy - animal	8/481	72/8135	0.06116	0.8519	0.8519	PRKN/UBB/AMBRA1/GABARAPL2/SQSTM1/TFE3/HRAS/BCL2L1	8
KEGG	hsa04062	Chemokine signaling pathway	17/481	192/8135	0.06162	0.8519	0.8519	GNG10/PPBP/MAPK1/STAT3/ELMO1/SOS1/CHUK/ADCY1/CCR10/PF4/JAK3/HRAS/CXCL5/STAT5B/VAV2/GRK1/CCL5	17
KEGG	hsa04145	Phagosome	14/481	152/8135	0.06529	0.8519	0.8519	MBL2/TUBB/FCGR2A/FCGR2B/ATP6V0C/TAP2/THBS1/TUBA3D/ACTB/ATP6V0E1/ATP6V1H/CORO1A/SEC61A2/HLA-A	14
KEGG	hsa04115	p53 signaling pathway	8/481	73/8135	0.06532	0.8519	0.8519	CDKN1A/CCNG1/ADGRB1/CDKN2A/TP53I3/PTEN/THBS1/BCL2L1	8
KEGG	hsa05340	Primary immunodeficiency	5/481	38/8135	0.07115	0.8846	0.8846	IGLL1/LCK/TNFRSF13C/TAP2/JAK3	5
KEGG	hsa05214	Glioma	8/481	75/8135	0.07415	0.8846	0.8846	CDKN1A/CAMK1D/CDKN2A/MAPK1/SOS1/PTEN/TGFA/HRAS	8
KEGG	hsa00270	Cysteine and methionine metabolism	6/481	51/8135	0.07865	0.8846	0.8846	PHGDH/DNMT1/DNMT3A/GCLM/KYAT1/APIP	6
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/481	89/8135	0.07913	0.8846	0.8846	NFATC2/LCK/MAPK1/STAT3/PTEN/CHUK/HRAS/PTPN11/MAP3K3	9
KEGG	hsa03440	Homologous recombination	5/481	41/8135	0.09222	0.9621	0.9621	UIMC1/RAD51D/POLD1/XRCC3/RPA3	5
KEGG	hsa05219	Bladder cancer	5/481	41/8135	0.09222	0.9621	0.9621	CDKN1A/CDKN2A/MAPK1/THBS1/HRAS	5
KEGG	hsa00030	Pentose phosphate pathway	4/481	30/8135	0.09816	0.9911	0.9911	RPE/PGLS/PGD/RBKS	4
KEGG	hsa04136	Autophagy - other	4/481	32/8135	0.1177	0.9965	0.9965	GABARAPL2/ATG4B/MLST8/ATG2A	4
KEGG	hsa04668	TNF signaling pathway	10/481	112/8135	0.1253	0.9965	0.9965	SOCS3/TRADD/RIPK1/MLKL/VEGFC/MAPK1/BCL3/CHUK/CXCL5/CCL5	10
KEGG	hsa03410	Base excision repair	4/481	33/8135	0.128	0.9965	0.9965	POLE2/LIG1/POLD1/PARP3	4
KEGG	hsa04140	Autophagy - animal	12/481	141/8135	0.1292	0.9965	0.9965	AMBRA1/GABARAPL2/RHEB/MAPK1/SQSTM1/DDIT4/ATG4B/PTEN/MLST8/HRAS/BCL2L1/ATG2A	12
KEGG	hsa04150	mTOR signaling pathway	13/481	156/8135	0.1323	0.9965	0.9965	SLC38A9/RHEB/SEC13/MAPK1/MAPKAP1/DDIT4/SOS1/PTEN/CHUK/MLST8/HRAS/ATP6V1H/LRP5	13
KEGG	hsa04218	Cellular senescence	13/481	156/8135	0.1323	0.9965	0.9965	RHEB/CDKN1A/NFATC2/CDKN2A/MAPK1/GATA4/SQSTM1/LIN37/PTEN/TGFBR2/RAD9A/HRAS/HLA-A	13
KEGG	hsa03050	Proteasome	5/481	46/8135	0.1335	0.9965	0.9965	PSMF1/PSMB2/PSMD9/PSMB11/PSMA6	5
KEGG	hsa04510	Focal adhesion	16/481	201/8135	0.1378	0.9965	0.9965	VEGFC/MYL9/MAPK1/FLT4/PAK4/SOS1/PTEN/THBS1/PGF/MYL5/ACTB/HRAS/DOCK1/VAV2/TLN1/COL9A1	16
KEGG	hsa01524	Platinum drug resistance	7/481	73/8135	0.139	0.9965	0.9965	XPA/ERCC1/CDKN1A/POLH/CDKN2A/MAPK1/BCL2L1	7
KEGG	hsa04080	Neuroactive ligand-receptor interaction	26/481	353/8135	0.1434	0.9965	0.9965	BDKRB1/ADCYAP1R1/SCTR/CYSLTR2/UTS2R/P2RY13/RXFP2/GAL/ADRA1B/LYPD6/NPB/AVP/NPW/HRH2/UCN3/OPRK1/GCG/LYNX1/GPR35/GRM6/GABRR2/ADRA1A/BRS3/GHRH/TAAR2/F2	26
KEGG	hsa05131	Shigellosis	19/481	247/8135	0.1435	0.9965	0.9965	UBB/SEPTIN7/TRADD/RIPK1/MYL9/UBE2D4/CAPNS1/MAPK1/SQSTM1/ELMO1/RBX1/SEPTIN11/CHUK/MYL5/ACTB/DOCK1/BCL2L1/TLN1/CCL5	19
KEGG	hsa04151	PI3K-Akt signaling pathway	26/481	354/8135	0.1466	0.9965	0.9965	GNG10/OSMR/RHEB/CDKN1A/VEGFC/IL3RA/TCL1A/YWHAE/MAPK1/FLT4/DDIT4/SOS1/YWHAQ/PTEN/THBS1/TGFA/CHUK/MLST8/PGF/JAK3/HRAS/CDC37/PPP2R2B/BCL2L1/IFNAR2/COL9A1	26
KEGG	hsa04068	FoxO signaling pathway	11/481	131/8135	0.1515	0.9965	0.9965	KLF2/GABARAPL2/CDKN1A/MAPK1/STAT3/SOS1/PTEN/TGFBR2/CHUK/HRAS/PRMT1	11
KEGG	hsa00350	Tyrosine metabolism	4/481	36/8135	0.1612	0.9965	0.9965	DCT/LRTOMT/GSTZ1/TH	4
KEGG	hsa03250	Viral life cycle - HIV-1	6/481	63/8135	0.167	0.9965	0.9965	NELFE/BST2/FURIN/CHMP6/APOBEC3H/PIN1	6
KEGG	hsa05110	Vibrio cholerae infection	5/481	50/8135	0.1715	0.9965	0.9965	ATP6V0C/ACTB/ATP6V0E1/ATP6V1H/SEC61A2	5
KEGG	hsa04658	Th1 and Th2 cell differentiation	8/481	92/8135	0.1761	0.9965	0.9965	NFATC2/LCK/NOTCH1/MAPK1/CHUK/JAK3/STAT5B/MAML3	8
KEGG	hsa04612	Antigen processing and presentation	7/481	78/8135	0.1769	0.9965	0.9965	KIR3DL3/KLRC3/B2M/TAP2/KIR2DS4/KIR3DL1/HLA-A	7
KEGG	hsa04721	Synaptic vesicle cycle	7/481	78/8135	0.1769	0.9965	0.9965	SNAP25/SLC1A7/ATP6V0C/AP2A1/SLC17A7/ATP6V0E1/ATP6V1H	7
KEGG	hsa05163	Human cytomegalovirus infection	17/481	225/8135	0.1777	0.9965	0.9965	GNG10/TRADD/RIPK1/RHEB/CDKN1A/NFATC2/B2M/CDKN2A/MAPK1/STAT3/TAP2/SOS1/CHUK/ADCY1/HRAS/HLA-A/CCL5	17
KEGG	hsa04210	Apoptosis	11/481	136/8135	0.1804	0.9965	0.9965	TRADD/RIPK1/IL3RA/MAPK1/CTSK/PARP3/CHUK/TUBA3D/ACTB/HRAS/BCL2L1	11
KEGG	hsa05014	Amyotrophic lateral sclerosis	26/481	364/8135	0.1812	0.9965	0.9965	DNAH11/PRKN/KLC2/AMBRA1/ATP5F1A/NDUFA12/POM121L2/COX5B/TUBB/SEC13/PSMB2/PSMD9/VCP/ANG/SQSTM1/DNAH2/PSMA6/NEFM/NDUFS5/TUBA3D/ACTB/KLC4/BCL2L1/NDUFA3/ATG2A/PRPH	26
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/481	79/8135	0.185	0.9965	0.9965	MAPK1/STAT3/SOS1/PTEN/TGFA/HRAS/BCL2L1	7
KEGG	hsa05170	Human immunodeficiency virus 1 infection	16/481	212/8135	0.1878	0.9965	0.9965	GNG10/TRADD/RIPK1/BST2/APOBEC3H/NFATC2/B2M/MAPK1/PAK4/TAP2/RBX1/CHUK/HRAS/CFL1/BCL2L1/HLA-A	16
KEGG	hsa03013	Nucleocytoplasmic transport	9/481	108/8135	0.1879	0.9965	0.9965	RNPS1/POM121L2/SEC13/IPO13/THOC6/TMEM33/TNPO2/PHAX/IPO11	9
KEGG	hsa05225	Hepatocellular carcinoma	13/481	168/8135	0.1941	0.9965	0.9965	FRAT2/CDKN1A/CDKN2A/MAPK1/SOS1/PTEN/TGFBR2/TGFA/ACTB/HRAS/LRP5/BCL2L1/SMARCC2	13
KEGG	hsa00790	Folate biosynthesis	3/481	26/8135	0.1966	0.9965	0.9965	DHFR/ALPP/TH	3
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/481	14/8135	0.1991	0.9965	0.9965	ST3GAL1/CHST6	2
KEGG	hsa05221	Acute myeloid leukemia	6/481	67/8135	0.2032	0.9965	0.9965	MAPK1/STAT3/SOS1/CHUK/HRAS/STAT5B	6
KEGG	hsa04110	Cell cycle	10/481	126/8135	0.211	0.9965	0.9965	MCM2/CDC14B/CDKN1A/YWHAE/ZBTB17/CDKN2A/TFDP1/ANAPC15/YWHAQ/RBX1	10
KEGG	hsa04014	Ras signaling pathway	17/481	232/8135	0.2114	0.9965	0.9965	GNG10/VEGFC/KSR1/RIN1/MAPK1/FLT4/PAK4/SOS1/PLA2G6/TGFA/CHUK/PGF/HRAS/RALA/PTPN11/PLA2G10/BCL2L1	17
KEGG	hsa04966	Collecting duct acid secretion	3/481	27/8135	0.2122	0.9965	0.9965	ATP6V0C/ATP6V0E1/CA2	3
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	8/481	97/8135	0.2142	0.9965	0.9965	SPHK2/FCGR2A/MAPK1/FCGR2B/PLA2G6/CFL1/DOCK1/VAV2	8
KEGG	hsa05215	Prostate cancer	8/481	97/8135	0.2142	0.9965	0.9965	ERG/CDKN1A/MAPK1/SOS1/PTEN/TGFA/CHUK/HRAS	8
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/481	15/8135	0.2213	0.9965	0.9965	GLB1/ST3GAL1	2
KEGG	hsa00730	Thiamine metabolism	2/481	15/8135	0.2213	0.9965	0.9965	ALPP/AK1	2
KEGG	hsa05203	Viral carcinogenesis	15/481	204/8135	0.2257	0.9965	0.9965	TRADD/CDKN1A/HDAC11/YWHAE/CDKN2A/MAPK1/STAT3/MRPS18B/YWHAQ/JAK3/HRAS/HDAC3/STAT5B/HDAC7/HLA-A	15
KEGG	hsa05012	Parkinson disease	19/481	266/8135	0.2267	0.9965	0.9965	PRKN/KLC2/UBB/UBE2L6/ATP5F1A/NDUFA12/SNCA/COX5B/TRAP1/TUBB/PSMB2/PSMD9/PSMA6/NDUFS5/TUBA3D/KLC4/TH/BCL2L1/NDUFA3	19
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/481	70/8135	0.2319	0.9965	0.9965	ATP6V0C/CHUK/ATP6V0E1/ATP6V1H/PTPN11/CCL5	6
KEGG	hsa00380	Tryptophan metabolism	4/481	42/8135	0.2351	0.9965	0.9965	KMO/KYAT1/ALDH9A1/IDO1	4
KEGG	hsa04012	ErbB signaling pathway	7/481	85/8135	0.2363	0.9965	0.9965	CDKN1A/MAPK1/PAK4/SOS1/TGFA/HRAS/STAT5B	7
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/481	16/8135	0.2436	0.9965	0.9965	GGT6/GAD1	2
KEGG	hsa05210	Colorectal cancer	7/481	86/8135	0.2453	0.9965	0.9965	CDKN1A/MAPK1/SOS1/TGFBR2/TGFA/HRAS/RALA	7
KEGG	hsa04975	Fat digestion and absorption	4/481	43/8135	0.2481	0.9965	0.9965	SLC27A4/AGPAT1/APOB/PLA2G10	4
KEGG	hsa04630	JAK-STAT signaling pathway	12/481	162/8135	0.25	0.9965	0.9965	SOCS3/OSMR/CDKN1A/IL3RA/STAT3/SOS1/JAK3/HRAS/PTPN11/STAT5B/BCL2L1/IFNAR2	12
KEGG	hsa05213	Endometrial cancer	5/481	58/8135	0.2575	0.9965	0.9965	CDKN1A/MAPK1/SOS1/PTEN/HRAS	5
KEGG	hsa01523	Antifolate resistance	3/481	30/8135	0.2603	0.9965	0.9965	DHFR/CHUK/FOLR2	3
KEGG	hsa04540	Gap junction	7/481	88/8135	0.2636	0.9965	0.9965	TUBB/MAPK1/SOS1/TUBA3D/ADCY1/HRAS/CSNK1D	7
KEGG	hsa00120	Primary bile acid biosynthesis	2/481	17/8135	0.2661	0.9965	0.9965	CYP39A1/CYP27A1	2
KEGG	hsa00450	Selenocompound metabolism	2/481	17/8135	0.2661	0.9965	0.9965	KYAT1/SEPHS1	2
KEGG	hsa00910	Nitrogen metabolism	2/481	17/8135	0.2661	0.9965	0.9965	CA1/CA2	2
KEGG	hsa04625	C-type lectin receptor signaling pathway	8/481	104/8135	0.2722	0.9965	0.9965	KSR1/CLEC6A/NFATC2/MAPK1/BCL3/CHUK/HRAS/PTPN11	8
KEGG	hsa04660	T cell receptor signaling pathway	8/481	104/8135	0.2722	0.9965	0.9965	NFATC2/LCK/MAPK1/PAK4/SOS1/CHUK/HRAS/VAV2	8
KEGG	hsa05130	Pathogenic Escherichia coli infection	14/481	197/8135	0.2758	0.9965	0.9965	TRADD/RIPK1/MYH14/CLDN34/TUBB/CLDN15/FCGR2A/MAPK1/BRK1/CHUK/TUBA3D/ACTB/PTPN11/F2	14
KEGG	hsa04710	Circadian rhythm	3/481	31/8135	0.2766	0.9965	0.9965	FBXL3/RBX1/CSNK1D	3
KEGG	hsa00061	Fatty acid biosynthesis	2/481	18/8135	0.2885	0.9965	0.9965	FASN/ACSBG1	2
KEGG	hsa05135	Yersinia infection	10/481	137/8135	0.2913	0.9965	0.9965	NFATC2/LCK/FCGR2A/MAPK1/ELMO1/CHUK/ACTB/DOCK1/GIT2/VAV2	10
KEGG	hsa00561	Glycerolipid metabolism	5/481	61/8135	0.2921	0.9965	0.9965	PNPLA3/DGKA/AGPAT1/ALDH9A1/DGKB	5
KEGG	hsa04060	Cytokine-cytokine receptor interaction	20/481	295/8135	0.2938	0.9965	0.9965	PPBP/OSMR/BMP6/ACVR2A/IL3RA/AMH/IL25/TNFRSF13C/IL17RC/CLCF1/TGFBR2/CCR10/PF4/ACKR4/GDF15/BMP8A/CXCL5/INHBC/IFNAR2/CCL5	20
KEGG	hsa04921	Oxytocin signaling pathway	11/481	154/8135	0.3021	0.9965	0.9965	CDKN1A/CAMK1D/NFATC2/MYL9/MAPK1/KCNJ18/ADCY1/ACTB/RCAN1/HRAS/TRPM2	11
KEGG	hsa05132	Salmonella infection	17/481	249/8135	0.3037	0.9965	0.9965	KLC2/TRADD/RIPK1/MLKL/TUBB/MYL9/MAPK1/ELMO1/VPS39/BRK1/CHUK/TUBA3D/MYL5/ACTB/HRAS/RALA/KLC4	17
KEGG	hsa04659	Th17 cell differentiation	8/481	108/8135	0.3071	0.9965	0.9965	NFATC2/LCK/MAPK1/STAT3/TGFBR2/CHUK/JAK3/STAT5B	8
KEGG	hsa04810	Regulation of actin cytoskeleton	15/481	218/8135	0.3085	0.9965	0.9965	BDKRB1/MYH14/MYL9/MAPK1/PAK4/BRK1/SOS1/TMSB4X/MYL5/ACTB/HRAS/CFL1/DOCK1/VAV2/F2	15
KEGG	hsa04141	Protein processing in endoplasmic reticulum	12/481	171/8135	0.3115	0.9965	0.9965	PRKN/MBTPS1/ERP29/HSPBP1/SEC13/VCP/UBE2D4/SEC23A/RBX1/UBE4B/RNF5/SEC61A2	12
KEGG	hsa00310	Lysine degradation	5/481	63/8135	0.3156	0.9965	0.9965	BBOX1/DOT1L/ALDH9A1/EHMT1/HYKK	5
KEGG	hsa04623	Cytosolic DNA-sensing pathway	5/481	63/8135	0.3156	0.9965	0.9965	RIPK1/POLR3K/CHUK/POLR2F/CCL5	5
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/481	143/8135	0.3383	0.9965	0.9965	PCGF2/ACVR2A/REST/MAPK1/STAT3/JAK3/HRAS/HOXD1/RIF1/INHBC	10
KEGG	hsa00510	N-Glycan biosynthesis	4/481	50/8135	0.3425	0.9965	0.9965	ALG12/MGAT4D/DPM2/MGAT2	4
KEGG	hsa00512	Mucin type O-glycan biosynthesis	3/481	36/8135	0.3591	0.9965	0.9965	GALNT2/ST3GAL1/GALNTL6	3
KEGG	hsa01522	Endocrine resistance	7/481	98/8135	0.3594	0.9965	0.9965	CDKN1A/NOTCH1/CDKN2A/MAPK1/SOS1/ADCY1/HRAS	7
KEGG	hsa05161	Hepatitis B	11/481	162/8135	0.3621	0.9965	0.9965	CDKN1A/NFATC2/MAPK1/STAT3/SOS1/YWHAQ/TGFBR2/CHUK/JAK3/HRAS/STAT5B	11
KEGG	hsa03040	Spliceosome	10/481	147/8135	0.3703	0.9965	0.9965	LSM3/DHX38/PUF60/SNRPB/PRPF19/SF3B4/RBMX/PRPF3/PPIH/PRPF4	10
KEGG	hsa05224	Breast cancer	10/481	147/8135	0.3703	0.9965	0.9965	FRAT2/CDKN1A/HEY1/NOTCH1/MAPK1/FLT4/SOS1/PTEN/HRAS/LRP5	10
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	3/481	37/8135	0.3756	0.9965	0.9965	ALDH4A1/GAD1/ASRGL1	3
KEGG	hsa05216	Thyroid cancer	3/481	37/8135	0.3756	0.9965	0.9965	CDKN1A/MAPK1/HRAS	3
KEGG	hsa04142	Lysosome	9/481	132/8135	0.379	0.9965	0.9965	CD63/GLB1/ATP6V0C/CTSK/CLN5/PPT1/ATP6V1H/LAPTM4B/AP4S1	9
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	30/481	476/8135	0.3838	0.9965	0.9965	DNAH11/PRKN/KLC2/UBB/AMBRA1/FRAT2/UBE2L6/ATP5F1A/NDUFA12/SNCA/COX5B/TRAP1/TUBB/PSMB2/PSMD9/VCP/MAPK1/SQSTM1/DNAH2/PSMA6/NEFM/NDUFS5/TUBA3D/HRAS/LRP5/KLC4/BCL2L1/NDUFA3/ATG2A/PRPH	30
KEGG	hsa04270	Vascular smooth muscle contraction	9/481	134/8135	0.3962	0.9965	0.9965	MYH14/ADRA1B/MYL9/AVP/MAPK1/PLA2G6/ADCY1/PLA2G10/ADRA1A	9
KEGG	hsa03460	Fanconi anemia pathway	4/481	54/8135	0.3973	0.9965	0.9965	EME2/ERCC1/POLH/RPA3	4
KEGG	hsa04714	Thermogenesis	15/481	232/8135	0.3981	0.9965	0.9965	ATP5F1A/NDUFA12/RHEB/COX5B/NDUFS5/SOS1/GCG/MLST8/ADCY1/ACTB/HRAS/BMP8A/NDUFA3/COX20/SMARCC2	15
KEGG	hsa04621	NOD-like receptor signaling pathway	12/481	184/8135	0.4056	0.9965	0.9965	RIPK1/GABARAPL2/CAMP/YWHAE/IFI16/MAPK1/CHUK/BCL2L1/IFNAR2/TRPM2/NLRP1/CCL5	12
KEGG	hsa04935	Growth hormone synthesis, secretion and action	8/481	119/8135	0.4068	0.9965	0.9965	SOCS3/MAPK1/STAT3/SOS1/ADCY1/HRAS/STAT5B/GHRH	8
KEGG	hsa00513	Various types of N-glycan biosynthesis	3/481	39/8135	0.4081	0.9965	0.9965	ALG12/MGAT4D/MGAT2	3
KEGG	hsa04520	Adherens junction	5/481	71/8135	0.411	0.9965	0.9965	NECTIN1/MAPK1/SNAI1/TGFBR2/ACTB	5
KEGG	hsa01240	Biosynthesis of cofactors	10/481	153/8135	0.4188	0.9965	0.9965	DHFR/ALPP/KMO/COQ5/PNPO/LIAS/GCLM/NMNAT1/AK1/IDO1	10
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/481	24/8135	0.4193	0.9965	0.9965	B4GALT7/XYLT2	2
KEGG	hsa05218	Melanoma	5/481	72/8135	0.4229	0.9965	0.9965	CDKN1A/CDKN2A/MAPK1/PTEN/HRAS	5
KEGG	hsa00260	Glycine, serine and threonine metabolism	3/481	40/8135	0.4242	0.9965	0.9965	PHGDH/GNMT/GRHPR	3
KEGG	hsa04919	Thyroid hormone signaling pathway	8/481	121/8135	0.4251	0.9965	0.9965	RHEB/NOTCH1/MAPK1/GATA4/ACTB/RCAN1/HRAS/HDAC3	8
KEGG	hsa04211	Longevity regulating pathway	6/481	89/8135	0.4315	0.9965	0.9965	RHEB/ADIPOQ/ADCY1/HRAS/EHMT1/ADIPOR1	6
KEGG	hsa01212	Fatty acid metabolism	4/481	57/8135	0.4378	0.9965	0.9965	SCD5/PPT1/FASN/ACSBG1	4
KEGG	hsa00592	alpha-Linolenic acid metabolism	2/481	25/8135	0.44	0.9965	0.9965	PLA2G6/PLA2G10	2
KEGG	hsa05016	Huntington disease	19/481	306/8135	0.4467	0.9965	0.9965	DNAH11/KLC2/AMBRA1/ATP5F1A/NDUFA12/REST/COX5B/TUBB/PSMB2/PSMD9/DNAH2/PSMA6/NDUFS5/AP2A1/TUBA3D/KLC4/POLR2F/NDUFA3/ATG2A	19
KEGG	hsa00480	Glutathione metabolism	4/481	58/8135	0.4512	0.9965	0.9965	PGD/GCLM/GGT6/GGCT	4
KEGG	hsa05332	Graft-versus-host disease	3/481	42/8135	0.456	0.9965	0.9965	KIR3DL3/KIR3DL1/HLA-A	3
KEGG	hsa03320	PPAR signaling pathway	5/481	75/8135	0.4583	0.9965	0.9965	SLC27A4/SCD5/ADIPOQ/ACSBG1/CYP27A1	5
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/481	26/8135	0.4602	0.9965	0.9965	DPM2/PIGO	2
KEGG	hsa04370	VEGF signaling pathway	4/481	59/8135	0.4644	0.9965	0.9965	SPHK2/NFATC2/MAPK1/HRAS	4
KEGG	hsa04936	Alcoholic liver disease	9/481	142/8135	0.4646	0.9965	0.9965	TRADD/RIPK1/IL17RC/SCD5/CHUK/ADIPOQ/FASN/ALDH9A1/ADIPOR1	9
KEGG	hsa00071	Fatty acid degradation	3/481	43/8135	0.4716	0.9965	0.9965	ALDH9A1/ECI1/ACSBG1	3
KEGG	hsa05202	Transcriptional misregulation in cancer	12/481	193/8135	0.4717	0.9965	0.9965	ERG/CDKN1A/ETV4/PAX7/SSX2B/ZBTB17/SSX2/DOT1L/TGFBR2/HOXA10/TFE3/BCL2L1	12
KEGG	hsa05323	Rheumatoid arthritis	6/481	93/8135	0.4739	0.9965	0.9965	ATP6V0C/CTSK/CXCL5/ATP6V0E1/ATP6V1H/CCL5	6
KEGG	hsa04978	Mineral absorption	4/481	60/8135	0.4776	0.9965	0.9965	MT1H/MT1B/SLC26A9/MT1E	4
KEGG	hsa05416	Viral myocarditis	4/481	60/8135	0.4776	0.9965	0.9965	EIF4G1/EIF4G2/ACTB/HLA-A	4
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/481	194/8135	0.479	0.9965	0.9965	GNG10/UBB/TRADD/CDKN1A/NFATC2/MAPK1/STAT3/CHUK/RCAN1/HRAS/IFNAR2/HLA-A	12
KEGG	hsa04657	IL-17 signaling pathway	6/481	94/8135	0.4844	0.9965	0.9965	TRADD/IL25/MAPK1/IL17RC/CHUK/CXCL5	6
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/481	11/8135	0.4887	0.9965	0.9965	COQ5	1
KEGG	hsa04926	Relaxin signaling pathway	8/481	129/8135	0.4974	0.9965	0.9965	GNG10/VEGFC/RXFP2/MAPK1/SOS1/TGFBR2/ADCY1/HRAS	8
KEGG	hsa04360	Axon guidance	11/481	182/8135	0.5151	0.9965	0.9965	EPHB6/NFATC2/MYL9/UNC5A/MAPK1/UNC5D/PAK4/MYL5/HRAS/CFL1/PTPN11	11
KEGG	hsa04670	Leukocyte transendothelial migration	7/481	114/8135	0.5152	0.9965	0.9965	CLDN34/MYL9/CLDN15/MYL5/ACTB/PTPN11/VAV2	7
KEGG	hsa04724	Glutamatergic synapse	7/481	114/8135	0.5152	0.9965	0.9965	GNG10/SLC1A7/MAPK1/ADCY1/SLC17A7/GRM6/SHANK3	7
KEGG	hsa04930	Type II diabetes mellitus	3/481	46/8135	0.517	0.9965	0.9965	SOCS3/MAPK1/ADIPOQ	3
KEGG	hsa00591	Linoleic acid metabolism	2/481	29/8135	0.5184	0.9965	0.9965	PLA2G6/PLA2G10	2
KEGG	hsa00564	Glycerophospholipid metabolism	6/481	98/8135	0.5256	0.9965	0.9965	PISD/PLA2G6/DGKA/AGPAT1/DGKB/PLA2G10	6
KEGG	hsa05231	Choline metabolism in cancer	6/481	98/8135	0.5256	0.9965	0.9965	RHEB/MAPK1/SOS1/DGKA/DGKB/HRAS	6
KEGG	hsa00620	Pyruvate metabolism	3/481	47/8135	0.5317	0.9965	0.9965	GRHPR/PC/ALDH9A1	3
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	2/481	30/8135	0.5368	0.9965	0.9965	PGP/GRHPR	2
KEGG	hsa00190	Oxidative phosphorylation	8/481	134/8135	0.5413	0.9965	0.9965	ATP5F1A/NDUFA12/COX5B/ATP6V0C/NDUFS5/ATP6V0E1/ATP6V1H/NDUFA3	8
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/481	100/8135	0.5456	0.9965	0.9965	PPBP/CCR10/PF4/ACKR4/CXCL5/CCL5	6
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/481	100/8135	0.5456	0.9965	0.9965	VEGFC/MAPK1/STAT3/TGFBR2/HRAS/STAT5B	6
KEGG	hsa04530	Tight junction	10/481	169/8135	0.5462	0.9965	0.9965	YBX3/MICALL2/MYH14/CLDN34/MYL9/CLDN15/GATA4/TUBA3D/ACTB/PPP2R2B	10
KEGG	hsa00052	Galactose metabolism	2/481	31/8135	0.5548	0.9965	0.9965	GALT/GLB1	2
KEGG	hsa00410	beta-Alanine metabolism	2/481	31/8135	0.5548	0.9965	0.9965	GAD1/ALDH9A1	2
KEGG	hsa05205	Proteoglycans in cancer	12/481	205/8135	0.5576	0.9965	0.9965	CDKN1A/CD63/MAPK1/STAT3/TIMP3/SOS1/THBS1/ACTB/HRAS/NUDT16L1/PTPN11/VAV2	12
KEGG	hsa00565	Ether lipid metabolism	3/481	49/8135	0.5603	0.9965	0.9965	PLA2G6/ENPP2/PLA2G10	3
KEGG	hsa04672	Intestinal immune network for IgA production	3/481	49/8135	0.5603	0.9965	0.9965	TNFRSF13C/PIGR/CCR10	3
KEGG	hsa04722	Neurotrophin signaling pathway	7/481	119/8135	0.5615	0.9965	0.9965	ARHGDIG/YWHAE/MAPK1/SOS1/HRAS/PTPN11/MAP3K3	7
KEGG	hsa05142	Chagas disease	6/481	102/8135	0.5653	0.9965	0.9965	MAPK1/TGFBR2/CHUK/ADCY1/PPP2R2B/CCL5	6
KEGG	hsa04910	Insulin signaling pathway	8/481	137/8135	0.5669	0.9965	0.9965	TRIP10/SOCS3/RHEB/MAPK1/SOS1/PRKAR1A/FASN/HRAS	8
KEGG	hsa04152	AMPK signaling pathway	7/481	120/8135	0.5705	0.9965	0.9965	RHEB/SCD5/ADIPOQ/FASN/PPP2R2B/ADIPOR1/ADRA1A	7
KEGG	hsa04979	Cholesterol metabolism	3/481	50/8135	0.5742	0.9965	0.9965	APOE/APOB/CYP27A1	3
KEGG	hsa04664	Fc epsilon RI signaling pathway	4/481	68/8135	0.5774	0.9965	0.9965	MAPK1/SOS1/HRAS/VAV2	4
KEGG	hsa05162	Measles	8/481	139/8135	0.5836	0.9965	0.9965	TRADD/STAT3/FCGR2B/CHUK/JAK3/STAT5B/BCL2L1/IFNAR2	8
KEGG	hsa04064	NF-kappa B signaling pathway	6/481	104/8135	0.5846	0.9965	0.9965	TRADD/RIPK1/LCK/TNFRSF13C/CHUK/BCL2L1	6
KEGG	hsa04620	Toll-like receptor signaling pathway	6/481	104/8135	0.5846	0.9965	0.9965	RIPK1/MAPK1/CTSK/CHUK/IFNAR2/CCL5	6
KEGG	hsa04390	Hippo signaling pathway	9/481	157/8135	0.5876	0.9965	0.9965	BMP6/AMH/YWHAE/YWHAQ/TGFBR2/ACTB/BMP8A/CSNK1D/PPP2R2B	9
KEGG	hsa05165	Human papillomavirus infection	19/481	331/8135	0.5887	0.9965	0.9965	TRADD/RHEB/CDKN1A/HEY1/NOTCH1/MAPK1/ATP6V0C/SOS1/PTEN/THBS1/CHUK/HRAS/ATP6V0E1/ATP6V1H/PPP2R2B/MAML3/IFNAR2/HLA-A/COL9A1	19
KEGG	hsa05010	Alzheimer disease	22/481	384/8135	0.5945	0.9965	0.9965	KLC2/AMBRA1/FRAT2/ATP5F1A/NDUFA12/SNCA/APOE/COX5B/TUBB/PSMB2/PSMD9/MAPK1/PSMA6/NDUFS5/RTN3/CHUK/TUBA3D/HRAS/LRP5/KLC4/NDUFA3/ATG2A	22
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/481	15/8135	0.5995	0.9965	0.9965	ST3GAL1	1
KEGG	hsa04622	RIG-I-like receptor signaling pathway	4/481	70/8135	0.6006	0.9965	0.9965	TRADD/RIPK1/CHUK/PIN1	4
KEGG	hsa05230	Central carbon metabolism in cancer	4/481	70/8135	0.6006	0.9965	0.9965	MAPK1/PTEN/HRAS/SLC16A3	4
KEGG	hsa00600	Sphingolipid metabolism	3/481	52/8135	0.6012	0.9965	0.9965	SMPD4/SPHK2/GLB1	3
KEGG	hsa04217	Necroptosis	9/481	159/8135	0.603	0.9965	0.9965	TRADD/RIPK1/MLKL/CHMP6/STAT3/SQSTM1/JAK3/STAT5B/IFNAR2	9
KEGG	hsa03020	RNA polymerase	2/481	34/8135	0.6056	0.9965	0.9965	POLR3K/POLR2F	2
KEGG	hsa04727	GABAergic synapse	5/481	89/8135	0.6118	0.9965	0.9965	GNG10/GABARAPL2/GAD1/ADCY1/GABRR2	5
KEGG	hsa05152	Tuberculosis	10/481	180/8135	0.6274	0.9965	0.9965	SPHK2/TRADD/CAMP/KSR1/FCGR2A/MAPK1/FCGR2B/ATP6V0C/ATP6V1H/CORO1A	10
KEGG	hsa04144	Endocytosis	14/481	251/8135	0.6297	0.9965	0.9965	CHMP6/ACAP3/SH3GLB2/ARFGAP2/VTA1/TGFBR2/AP2A1/HRAS/EHD3/SNX32/GIT2/GRK1/FOLR2/HLA-A	14
KEGG	hsa00500	Starch and sucrose metabolism	2/481	36/8135	0.637	0.9965	0.9965	GYG1/TREH	2
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	2/481	36/8135	0.637	0.9965	0.9965	NMNAT1/NNMT	2
KEGG	hsa05222	Small cell lung cancer	5/481	92/8135	0.6413	0.9965	0.9965	CDKN1A/ZBTB17/PTEN/CHUK/BCL2L1	5
KEGG	hsa04912	GnRH signaling pathway	5/481	93/8135	0.6508	0.9965	0.9965	MAPK1/SOS1/ADCY1/HRAS/MAP3K3	5
KEGG	hsa01250	Biosynthesis of nucleotide sugars	2/481	37/8135	0.6519	0.9965	0.9965	GALT/GNPNAT1	2
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	2/481	37/8135	0.6519	0.9965	0.9965	MAPK1/SLC9A3R2	2
KEGG	hsa04723	Retrograde endocannabinoid signaling	8/481	148/8135	0.6547	0.9965	0.9965	GNG10/NDUFA12/MAPK1/NDUFS5/ADCY1/SLC17A7/GABRR2/NDUFA3	8
KEGG	hsa05020	Prion disease	15/481	273/8135	0.6549	0.9965	0.9965	KLC2/ATP5F1A/NDUFA12/COX5B/TUBB/PSMB2/PSMD9/NOTCH1/MAPK1/PSMA6/NDUFS5/TUBA3D/KLC4/NDUFA3/CCL5	15
KEGG	hsa05169	Epstein-Barr virus infection	11/481	202/8135	0.6557	0.9965	0.9965	TRADD/RIPK1/CDKN1A/B2M/STAT3/TAP2/CIR1/CHUK/JAK3/IFNAR2/HLA-A	11
KEGG	hsa04514	Cell adhesion molecules	8/481	149/8135	0.6622	0.9965	0.9965	NECTIN1/NLGN4X/CLDN34/CLDN15/NLGN3/NRCAM/NFASC/HLA-A	8
KEGG	hsa05206	MicroRNAs in cancer	17/481	310/8135	0.6635	0.9965	0.9965	DNMT1/DNMT3A/CDKN1A/CCNG1/NOTCH1/CDKN2A/MAPK1/STAT3/IGF2BP1/PAK4/TIMP3/DDIT4/ST14/SOS1/PTEN/THBS1/HRAS	17
KEGG	hsa04971	Gastric acid secretion	4/481	76/8135	0.6655	0.9965	0.9965	HRH2/ADCY1/ACTB/CA2	4
KEGG	hsa04725	Cholinergic synapse	6/481	113/8135	0.6655	0.9965	0.9965	GNG10/KCNQ5/MAPK1/KCNJ18/ADCY1/HRAS	6
KEGG	hsa00511	Other glycan degradation	1/481	18/8135	0.6665	0.9965	0.9965	GLB1	1
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/481	223/8135	0.675	0.9965	0.9965	ATP5F1A/NDUFA12/COX5B/MAPK1/SLC26A9/NDUFS5/SOS1/PTEN/CHUK/HRAS/PTPN11/NDUFA3	12
KEGG	hsa05100	Bacterial invasion of epithelial cells	4/481	77/8135	0.6756	0.9965	0.9965	ELMO1/SEPTIN11/ACTB/DOCK1	4
KEGG	hsa05150	Staphylococcus aureus infection	5/481	96/8135	0.6783	0.9965	0.9965	MBL2/CAMP/KRT36/FCGR2A/FCGR2B	5
KEGG	hsa05414	Dilated cardiomyopathy	5/481	96/8135	0.6783	0.9965	0.9965	TNNT2/EMD/ADCY1/ACTB/TPM4	5
KEGG	hsa01200	Carbon metabolism	6/481	115/8135	0.6821	0.9965	0.9965	PHGDH/RPE/PGLS/PGP/PGD/PC	6
KEGG	hsa00531	Glycosaminoglycan degradation	1/481	19/8135	0.6863	0.9965	0.9965	GLB1	1
KEGG	hsa05033	Nicotine addiction	2/481	40/8135	0.6938	0.9965	0.9965	SLC17A7/GABRR2	2
KEGG	hsa03018	RNA degradation	4/481	79/8135	0.6951	0.9965	0.9965	LSM3/BTG1/EXOSC5/DCPS	4
KEGG	hsa00670	One carbon pool by folate	1/481	20/8135	0.7049	0.9965	0.9965	DHFR	1
KEGG	hsa04015	Rap1 signaling pathway	11/481	210/8135	0.7051	0.9965	0.9965	VEGFC/MAPK1/FLT4/THBS1/PGF/ADCY1/ACTB/HRAS/RALA/VAV2/TLN1	11
KEGG	hsa04071	Sphingolipid signaling pathway	6/481	119/8135	0.7136	0.9965	0.9965	SPHK2/TRADD/MAPK1/PTEN/HRAS/PPP2R2B	6
KEGG	hsa04915	Estrogen signaling pathway	7/481	138/8135	0.7156	0.9965	0.9965	KRT36/MAPK1/SOS1/TGFA/ADCY1/HRAS/EBAG9	7
KEGG	hsa04213	Longevity regulating pathway - multiple species	3/481	62/8135	0.7185	0.9965	0.9965	CLPB/ADCY1/HRAS	3
KEGG	hsa03010	Ribosome	8/481	158/8135	0.7248	0.9965	0.9965	RPS12/MRPL21/MRPS16/RPL7A/RPL28/MRPL2/RPS7/RPS2	8
KEGG	hsa05171	Coronavirus disease - COVID-19	12/481	232/8135	0.7264	0.9965	0.9965	MBL2/RPS12/FCGR2A/MAPK1/STAT3/RPL7A/RPL28/CHUK/RPS7/RPS2/IFNAR2/F2	12
KEGG	hsa04940	Type I diabetes mellitus	2/481	43/8135	0.7315	0.9965	0.9965	GAD1/HLA-A	2
KEGG	hsa04974	Protein digestion and absorption	5/481	103/8135	0.7368	0.9965	0.9965	COL5A1/ELN/SLC36A3/COL5A3/COL9A1	5
KEGG	hsa00340	Histidine metabolism	1/481	22/8135	0.7388	0.9965	0.9965	ALDH9A1	1
KEGG	hsa04962	Vasopressin-regulated water reabsorption	2/481	44/8135	0.7431	0.9965	0.9965	ARHGDIG/AVP	2
KEGG	hsa01232	Nucleotide metabolism	4/481	85/8135	0.7486	0.9965	0.9965	GMPR/AK1/ADA2/APRT	4
KEGG	hsa04611	Platelet activation	6/481	124/8135	0.7499	0.9965	0.9965	FCGR2A/MAPK1/ADCY1/ACTB/TLN1/F2	6
KEGG	hsa03022	Basal transcription factors	2/481	45/8135	0.7543	0.9965	0.9965	TAF12/TAF1L	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	1/481	23/8135	0.7543	0.9965	0.9965	CA2	1
KEGG	hsa04911	Insulin secretion	4/481	86/8135	0.7568	0.9965	0.9965	ADCYAP1R1/SNAP25/GCG/ADCY1	4
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	5/481	106/8135	0.7594	0.9965	0.9965	CDKN1A/MAPK1/ADCY1/PDE4B/LRP5	5
KEGG	hsa04720	Long-term potentiation	3/481	67/8135	0.7663	0.9965	0.9965	MAPK1/ADCY1/HRAS	3
KEGG	hsa04977	Vitamin digestion and absorption	1/481	24/8135	0.7689	0.9965	0.9965	APOB	1
KEGG	hsa04512	ECM-receptor interaction	4/481	88/8135	0.7725	0.9965	0.9965	DSPP/THBS1/SV2B/COL9A1	4
KEGG	hsa04931	Insulin resistance	5/481	108/8135	0.7736	0.9965	0.9965	SOCS3/SLC27A4/STAT3/PTEN/PTPN11	5
KEGG	hsa00514	Other types of O-glycan biosynthesis	2/481	47/8135	0.7755	0.9965	0.9965	GALNT2/GALNTL6	2
KEGG	hsa00230	Purine metabolism	6/481	128/8135	0.7764	0.9965	0.9965	GMPR/AK1/ADA2/APRT/ADCY1/PDE4B	6
KEGG	hsa04310	Wnt signaling pathway	8/481	167/8135	0.7792	0.9965	0.9965	FRAT2/NFATC2/SFRP2/TLE1/RBX1/CTBP1/LRP5/PRICKLE2	8
KEGG	hsa05226	Gastric cancer	7/481	149/8135	0.7861	0.9965	0.9965	FRAT2/CDKN1A/MAPK1/SOS1/TGFBR2/HRAS/LRP5	7
KEGG	hsa05410	Hypertrophic cardiomyopathy	4/481	90/8135	0.7874	0.9965	0.9965	TNNT2/EMD/ACTB/TPM4	4
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	7/481	150/8135	0.7918	0.9965	0.9965	TNNT2/ADRA1B/MAPK1/ADCY1/PPP2R2B/ADRA1A/TPM4	7
KEGG	hsa05032	Morphine addiction	4/481	91/8135	0.7946	0.9965	0.9965	GNG10/ADCY1/PDE4B/GABRR2	4
KEGG	hsa04114	Oocyte meiosis	6/481	131/8135	0.7949	0.9965	0.9965	YWHAE/MAPK1/ANAPC15/YWHAQ/RBX1/ADCY1	6
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	2/481	49/8135	0.795	0.9965	0.9965	GALT/GNPNAT1	2
KEGG	hsa05030	Cocaine addiction	2/481	49/8135	0.795	0.9965	0.9965	GPSM1/TH	2
KEGG	hsa04950	Maturity onset diabetes of the young	1/481	26/8135	0.7955	0.9965	0.9965	HNF1B	1
KEGG	hsa00062	Fatty acid elongation	1/481	27/8135	0.8076	0.9965	0.9965	PPT1	1
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	1/481	27/8135	0.8076	0.9965	0.9965	SCD5	1
KEGG	hsa04970	Salivary secretion	4/481	93/8135	0.8083	0.9965	0.9965	CAMP/ADRA1B/ADCY1/ADRA1A	4
KEGG	hsa00330	Arginine and proline metabolism	2/481	51/8135	0.8131	0.9965	0.9965	ALDH4A1/ALDH9A1	2
KEGG	hsa04913	Ovarian steroidogenesis	2/481	51/8135	0.8131	0.9965	0.9965	BMP6/ADCY1	2
KEGG	hsa04932	Non-alcoholic fatty liver disease	7/481	155/8135	0.8187	0.9965	0.9965	SOCS3/NDUFA12/COX5B/NDUFS5/ADIPOQ/ADIPOR1/NDUFA3	7
KEGG	hsa00650	Butanoate metabolism	1/481	28/8135	0.819	0.9965	0.9965	GAD1	1
KEGG	hsa05168	Herpes simplex virus 1 infection	25/481	495/8135	0.8251	0.9965	0.9965	ZNF93/SOCS3/NECTIN1/TRADD/BST2/RHEB/ZNF688/ZNF273/ZNF556/B2M/ZNF662/ZNF527/ZNF250/TAP2/CHUK/ZNF799/ZNF30/PTPN11/ZNF676/ZNF470/BCL2L1/ZNF517/IFNAR2/HLA-A/CCL5	25
KEGG	hsa01230	Biosynthesis of amino acids	3/481	75/8135	0.8288	0.9965	0.9965	PHGDH/RPE/PC	3
KEGG	hsa04392	Hippo signaling pathway - multiple species	1/481	29/8135	0.8298	0.9965	0.9965	DCHS2	1
KEGG	hsa04744	Phototransduction	1/481	29/8135	0.8298	0.9965	0.9965	GRK1	1
KEGG	hsa04070	Phosphatidylinositol signaling system	4/481	97/8135	0.8336	0.9965	0.9965	PIP4P1/PTEN/DGKA/DGKB	4
KEGG	hsa04713	Circadian entrainment	4/481	97/8135	0.8336	0.9965	0.9965	GNG10/ADCYAP1R1/MAPK1/ADCY1	4
KEGG	hsa05133	Pertussis	3/481	76/8135	0.8355	0.9965	0.9965	MAPK1/CXCL5/CFL1	3
KEGG	hsa04010	MAPK signaling pathway	14/481	294/8135	0.836	0.9965	0.9965	MAPK8IP2/TRADD/VEGFC/MAPK1/FLT4/SOS1/TGFBR2/DUSP5/TGFA/CHUK/PGF/HRAS/MAP3K3/PPM1A	14
KEGG	hsa04371	Apelin signaling pathway	6/481	139/8135	0.8385	0.9965	0.9965	GNG10/SPHK2/KLF2/MAPK1/ADCY1/HRAS	6
KEGG	hsa00020	Citrate cycle (TCA cycle)	1/481	30/8135	0.8399	0.9965	0.9965	PC	1
KEGG	hsa00053	Ascorbate and aldarate metabolism	1/481	30/8135	0.8399	0.9965	0.9965	ALDH9A1	1
KEGG	hsa04024	cAMP signaling pathway	10/481	221/8135	0.8501	0.9965	0.9965	ADCYAP1R1/AMH/MYL9/MAPK1/GCG/ADCY1/PDE4B/CNGA4/HCN4/VAV2	10
KEGG	hsa04340	Hedgehog signaling pathway	2/481	56/8135	0.8521	0.9965	0.9965	MEGF8/CSNK1D	2
KEGG	hsa04923	Regulation of lipolysis in adipocytes	2/481	56/8135	0.8521	0.9965	0.9965	ADCY1/ABHD5	2
KEGG	hsa04916	Melanogenesis	4/481	101/8135	0.856	0.9965	0.9965	DCT/MAPK1/ADCY1/HRAS	4
KEGG	hsa05415	Diabetic cardiomyopathy	9/481	203/8135	0.8563	0.9965	0.9965	ATP5F1A/NDUFA12/COX5B/NDUFS5/PTEN/TGFBR2/MPC2/NDUFA3/PDK3	9
KEGG	hsa05017	Spinocerebellar ataxia	6/481	143/8135	0.8573	0.9965	0.9965	AMBRA1/PSMB2/PSMD9/CIC/PSMA6/ATG2A	6
KEGG	hsa04215	Apoptosis - multiple species	1/481	32/8135	0.8583	0.9965	0.9965	BCL2L1	1
KEGG	hsa04972	Pancreatic secretion	4/481	102/8135	0.8612	0.9965	0.9965	SCTR/ADCY1/PLA2G10/CA2	4
KEGG	hsa04130	SNARE interactions in vesicular transport	1/481	33/8135	0.8667	0.9965	0.9965	VTI1B	1
KEGG	hsa05034	Alcoholism	8/481	187/8135	0.8711	0.9965	0.9965	GNG10/HDAC11/MAPK1/SOS1/HRAS/HDAC3/TH/HDAC7	8
KEGG	hsa04022	cGMP-PKG signaling pathway	7/481	167/8135	0.8721	0.9965	0.9965	ADRA1B/NFATC2/MYL9/MAPK1/GATA4/ADCY1/ADRA1A	7
KEGG	hsa00040	Pentose and glucuronate interconversions	1/481	34/8135	0.8746	0.9965	0.9965	RPE	1
KEGG	hsa04730	Long-term depression	2/481	60/8135	0.8778	0.9965	0.9965	MAPK1/HRAS	2
KEGG	hsa00590	Arachidonic acid metabolism	2/481	61/8135	0.8835	0.9965	0.9965	PLA2G6/PLA2G10	2
KEGG	hsa04610	Complement and coagulation cascades	3/481	85/8135	0.8863	0.9965	0.9965	BDKRB1/MBL2/F2	3
KEGG	hsa05164	Influenza A	7/481	171/8135	0.8867	0.9965	0.9965	SOCS3/TRADD/MAPK1/CHUK/ACTB/IFNAR2/CCL5	7
KEGG	hsa04066	HIF-1 signaling pathway	4/481	109/8135	0.8932	0.9965	0.9965	CDKN1A/MAPK1/STAT3/RBX1	4
KEGG	hsa04260	Cardiac muscle contraction	3/481	87/8135	0.8955	0.9965	0.9965	COX5B/TNNT2/TPM4	3
KEGG	hsa05143	African trypanosomiasis	1/481	37/8135	0.8957	0.9965	0.9965	IDO1	1
KEGG	hsa05417	Lipid and atherosclerosis	9/481	215/8135	0.8967	0.9965	0.9965	NFATC2/MAPK1/STAT3/CHUK/HRAS/APOB/BCL2L1/VAV2/CCL5	9
KEGG	hsa04929	GnRH secretion	2/481	64/8135	0.8993	0.9965	0.9965	MAPK1/HRAS	2
KEGG	hsa05330	Allograft rejection	1/481	38/8135	0.9019	0.9965	0.9965	HLA-A	1
KEGG	hsa04976	Bile secretion	3/481	89/8135	0.904	0.9965	0.9965	SCTR/ADCY1/CA2	3
KEGG	hsa05145	Toxoplasmosis	4/481	112/8135	0.9048	0.9965	0.9965	MAPK1/STAT3/CHUK/BCL2L1	4
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	2/481	66/8135	0.9087	0.9965	0.9965	FARS2/FARSA	2
KEGG	hsa04020	Calcium signaling pathway	10/481	240/8135	0.9095	0.9965	0.9965	BDKRB1/SPHK2/VEGFC/CAMK1D/CYSLTR2/ADRA1B/HRH2/FLT4/ADCY1/ADRA1A	10
KEGG	hsa00830	Retinol metabolism	2/481	68/8135	0.9173	0.9965	0.9965	RDH10/RDH8	2
KEGG	hsa04216	Ferroptosis	1/481	41/8135	0.9183	0.9965	0.9965	GCLM	1
KEGG	hsa05418	Fluid shear stress and atherosclerosis	5/481	139/8135	0.9205	0.9965	0.9965	KLF2/ACVR2A/SQSTM1/CHUK/ACTB	5
KEGG	hsa03015	mRNA surveillance pathway	3/481	97/8135	0.9322	0.9965	0.9965	RNPS1/SSU72/PPP2R2B	3
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	3/481	98/8135	0.9351	0.9965	0.9965	BDKRB1/PLA2G6/ADCY1	3
KEGG	hsa02010	ABC transporters	1/481	45/8135	0.9361	0.9965	0.9965	TAP2	1
KEGG	hsa04613	Neutrophil extracellular trap formation	7/481	190/8135	0.9384	0.9965	0.9965	CAMP/HDAC11/FCGR2A/MAPK1/ACTB/HDAC3/HDAC7	7
KEGG	hsa04918	Thyroid hormone synthesis	2/481	75/8135	0.9417	0.9965	0.9965	TTR/ADCY1	2
KEGG	hsa04914	Progesterone-mediated oocyte maturation	3/481	102/8135	0.9457	0.9965	0.9965	MAPK1/ANAPC15/ADCY1	3
KEGG	hsa00280	Valine, leucine and isoleucine degradation	1/481	48/8135	0.9468	0.9965	0.9965	ALDH9A1	1
KEGG	hsa05140	Leishmaniasis	2/481	77/8135	0.9473	0.9965	0.9965	FCGR2A/MAPK1	2
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/481	77/8135	0.9473	0.9965	0.9965	EMD/ACTB	2
KEGG	hsa05144	Malaria	1/481	50/8135	0.953	0.9965	0.9965	THBS1	1
KEGG	hsa04934	Cushing syndrome	5/481	155/8135	0.9565	0.9965	0.9965	RBBP5/CDKN1A/CDKN2A/MAPK1/ADCY1	5
KEGG	hsa04728	Dopaminergic synapse	4/481	132/8135	0.9574	0.9965	0.9965	GNG10/LRTOMT/PPP2R2B/TH	4
KEGG	hsa04146	Peroxisome	2/481	82/8135	0.9591	0.9965	0.9965	PEX11A/PEX10	2
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/481	53/8135	0.9609	0.9965	0.9965	AP2A1	1
KEGG	hsa05320	Autoimmune thyroid disease	1/481	53/8135	0.9609	0.9965	0.9965	HLA-A	1
KEGG	hsa04742	Taste transduction	2/481	86/8135	0.9667	0.9965	0.9965	TRPM5/HCN4	2
KEGG	hsa05134	Legionellosis	1/481	57/8135	0.9694	0.9965	0.9965	VCP	1
KEGG	hsa04726	Serotonergic synapse	3/481	115/8135	0.97	0.9965	0.9965	GNG10/MAPK1/HRAS	3
KEGG	hsa00140	Steroid hormone biosynthesis	1/481	61/8135	0.9761	0.9965	0.9965	LRTOMT	1
KEGG	hsa05217	Basal cell carcinoma	1/481	63/8135	0.9788	0.9965	0.9965	CDKN1A	1
KEGG	hsa04927	Cortisol synthesis and secretion	1/481	65/8135	0.9813	0.9965	0.9965	ADCY1	1
KEGG	hsa05321	Inflammatory bowel disease	1/481	65/8135	0.9813	0.9965	0.9965	STAT3	1
KEGG	hsa04925	Aldosterone synthesis and secretion	2/481	98/8135	0.9822	0.9965	0.9965	CAMK1D/ADCY1	2
KEGG	hsa04640	Hematopoietic cell lineage	2/481	99/8135	0.9832	0.9965	0.9965	IL3RA/CD9	2
KEGG	hsa00010	Glycolysis / Gluconeogenesis	1/481	67/8135	0.9834	0.9965	0.9965	ALDH9A1	1
KEGG	hsa04924	Renin secretion	1/481	69/8135	0.9854	0.9965	0.9965	ADCYAP1R1	1
KEGG	hsa05031	Amphetamine addiction	1/481	69/8135	0.9854	0.9965	0.9965	TH	1
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	6/481	212/8135	0.9883	0.9965	0.9965	MAPK1/STAT3/SOS1/ADCY1/HRAS/STAT5B	6
KEGG	hsa00562	Inositol phosphate metabolism	1/481	73/8135	0.9885	0.9965	0.9965	PTEN	1
KEGG	hsa04922	Glucagon signaling pathway	2/481	107/8135	0.989	0.9965	0.9965	GCG/PRMT1	2
KEGG	hsa04740	Olfactory transduction	16/481	440/8135	0.9897	0.9965	0.9965	OR2L3/OR2B2/OR5H1/OR2V2/OR10G3/OR4D6/OR10P1/OR4M1/OR2B6/OR2L8/OR2C3/OR2T1/OR2T2/OR2T35/CNGA4/OR4D2	16
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	2/481	109/8135	0.9901	0.9965	0.9965	TBL3/GNL2	2
KEGG	hsa05322	Systemic lupus erythematosus	2/481	136/8135	0.9977	0.9981	0.9981	FCGR2A/SNRPB	2
KEGG	hsa05146	Amoebiasis	1/481	102/8135	0.9981	0.9981	0.9981	ADCY1	1