ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	16/532	106/8135	0.001349	0.2418	0.2363	ARAF/RXRB/PRKCG/MMP14/PRKACB/CREB3L3/CREB3L4/FOS/EGR1/HBEGF/MAPK3/ITPR1/ATF6B/ARHGEF1/ARRB1/CDKN1A	16
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	8/532	37/8135	0.00226	0.2418	0.2363	NAT8L/GPT/GLUD2/GLUL/ALDH4A1/RIMKLB/ASRGL1/CPS1	8
KEGG	hsa05216	Thyroid cancer	8/532	37/8135	0.00226	0.2418	0.2363	TPM3/RXRB/TFG/NTRK1/PAX8/MAPK3/TCF7/CDKN1A	8
KEGG	hsa04918	Thyroid hormone synthesis	11/532	75/8135	0.009071	0.5507	0.5382	LRP2/GPX3/PRKCG/PRKACB/PAX8/CREB3L3/CREB3L4/ASGR1/GPX1/ITPR1/ATF6B	11
KEGG	hsa04120	Ubiquitin mediated proteolysis	17/532	142/8135	0.01103	0.5507	0.5382	HUWE1/UBE2NL/UBE2D1/UBR5/ANAPC13/NEDD4L/CDC27/UBE3B/UBE2D3/BTRC/ANAPC7/UBE2I/HERC3/UBE2N/UBE2E2/UBE4B/FANCL	17
KEGG	hsa04114	Oocyte meiosis	16/532	131/8135	0.01121	0.5507	0.5382	AURKA/ANAPC13/PRKACB/SPDYE2/SPDYE3/STAG3/CDC27/BTRC/YWHAE/MAPK3/ANAPC7/CCNE1/CALM1/ITPR1/PPP2CA/YWHAH	16
KEGG	hsa04728	Dopaminergic synapse	16/532	132/8135	0.01201	0.5507	0.5382	GRIA4/PRKCG/PRKACB/CREB3L3/CREB3L4/FOS/DRD3/CACNA1B/MAPK9/CALM1/ITPR1/PPP2CA/ATF6B/ARRB1/PPP2R2C/LRTOMT	16
KEGG	hsa04724	Glutamatergic synapse	14/532	114/8135	0.01629	0.581	0.5677	GRM4/GRIA4/GRIK2/SHANK1/GRIK3/PLA2G4F/PRKCG/GRIK5/GLUL/PRKACB/PLA2G4A/SHANK3/MAPK3/ITPR1	14
KEGG	hsa05165	Human papillomavirus infection	32/532	331/8135	0.01629	0.581	0.5677	MAML3/TSC2/PIK3CB/TNR/TERT/COL4A1/TUBG1/ATP6V0E1/LLGL2/PRKACB/TUBG2/FZD9/ATP6V1H/CREB3L3/CREB3L4/IFNA4/CSNK1A1/COL9A1/LAMC2/ATP6V1E1/IKBKE/MAPK3/CCNE1/MAML2/TCF7/PPP2CA/LAMA4/PPP2R2C/MAML1/HES2/HES5/CDKN1A	32
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	23/532	222/8135	0.01864	0.5984	0.5848	PIK3CB/SMAD2/TERT/ANAPC13/PRKACB/ELK1/ELK4/CREB3L3/CD40/CREB3L4/FOS/EGR1/ZFP36/CDC27/ETS1/MAPK3/ANAPC7/MAPK9/CCNE1/ATF6B/CRTC3/TNFRSF13C/CDKN1A	23
KEGG	hsa00910	Nitrogen metabolism	4/532	17/8135	0.02174	0.6125	0.5986	CA7/GLUD2/GLUL/CPS1	4
KEGG	hsa04935	Growth hormone synthesis, secretion and action	14/532	119/8135	0.0229	0.6125	0.5986	PIK3CB/GH1/PRKCG/PRKACB/CREB3L3/CRK/CREB3L4/FOS/MAPK3/CSH1/MAPK9/SSTR2/ITPR1/ATF6B	14
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/532	27/8135	0.02858	0.6395	0.6249	ST8SIA1/FUT7/ABO/FUT5/B3GNT5	5
KEGG	hsa05031	Amphetamine addiction	9/532	69/8135	0.03478	0.6395	0.6249	GRIA4/PRKCG/PRKACB/ARC/CREB3L3/CREB3L4/FOS/CALM1/ATF6B	9
KEGG	hsa05211	Renal cell carcinoma	9/532	69/8135	0.03478	0.6395	0.6249	ARAF/PIK3CB/CRK/ETS1/MAPK3/HIF1A/PAK3/PRCC/CDKN1A	9
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	21/532	212/8135	0.03666	0.6395	0.6249	RXRB/PIK3CB/PRKCG/FGF3/MGST1/PRKACB/CYP1A2/CDC6/CREB3L3/CREB3L4/GSTA2/FOS/KPNA6/IKBKE/MAPK3/CACNA1B/FGF22/UGT2B11/ATF6B/ARRB1/UGT1A6	21
KEGG	hsa04912	GnRH signaling pathway	11/532	93/8135	0.03951	0.6395	0.6249	PLA2G4F/MMP14/PRKACB/ELK1/PLA2G4A/EGR1/HBEGF/MAPK3/MAPK9/CALM1/ITPR1	11
KEGG	hsa04730	Long-term depression	8/532	60/8135	0.04036	0.6395	0.6249	ARAF/PLA2G4F/PRKCG/PLA2G4A/MAPK3/CRHR1/ITPR1/PPP2CA	8
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	5/532	30/8135	0.04301	0.6395	0.6249	CAT/GRHPR/GLUL/PGP/PCCB	5
KEGG	hsa05219	Bladder cancer	6/532	41/8135	0.04862	0.6395	0.6249	ARAF/DAPK1/HBEGF/MAPK3/UPK3A/CDKN1A	6
KEGG	hsa04710	Circadian rhythm	5/532	31/8135	0.04863	0.6395	0.6249	CSNK1E/RORB/BTRC/PRKAG1/PER3	5
KEGG	hsa03450	Non-homologous end-joining	3/532	13/8135	0.04863	0.6395	0.6249	POLL/NHEJ1/DCLRE1C	3
KEGG	hsa04012	ErbB signaling pathway	10/532	85/8135	0.04976	0.6395	0.6249	ARAF/PIK3CB/PRKCG/ELK1/CRK/HBEGF/MAPK3/MAPK9/PAK3/CDKN1A	10
KEGG	hsa00220	Arginine biosynthesis	4/532	22/8135	0.05168	0.6395	0.6249	GPT/GLUD2/GLUL/CPS1	4
KEGG	hsa04919	Thyroid hormone signaling pathway	13/532	121/8135	0.05207	0.6395	0.6249	TSC2/DIO2/RXRB/PIK3CB/PRKCG/MED1/PFKFB2/PRKACB/DIO3/PLCE1/MAPK3/HIF1A/NCOA2	13
KEGG	hsa00380	Tryptophan metabolism	6/532	42/8135	0.05373	0.6395	0.6249	IDO1/CAT/CYP1A2/ALDH1B1/INMT/TPH2	6
KEGG	hsa05231	Choline metabolism in cancer	11/532	98/8135	0.05439	0.6395	0.6249	TSC2/PIK3CB/CHKA/PLA2G4F/PRKCG/PLA2G4A/FOS/SLC44A5/MAPK3/MAPK9/HIF1A	11
KEGG	hsa04080	Neuroactive ligand-receptor interaction	31/532	353/8135	0.05578	0.6395	0.6249	GRM4/GRIA4/NPY5R/KISS1/LTB4R/GRIK2/GABRE/IAPP/PTGER2/GRIK3/HCRTR1/GH1/GRIK5/PLG/DRD3/LYPD6/ADORA1/HTR6/AVPR1B/CRHR1/CSH1/MC5R/CHRNB3/CHRM1/RXFP3/P2RX5/NMUR1/GLP2R/SSTR2/MC3R/HRH4	31
KEGG	hsa04927	Cortisol synthesis and secretion	8/532	65/8135	0.06016	0.6539	0.6389	PRKACB/CREB3L3/CREB3L4/PDE8B/ITPR1/HSD3B1/ATF6B/CYP11B1	8
KEGG	hsa04611	Platelet activation	13/532	124/8135	0.06111	0.6539	0.6389	PIK3CB/MYLK2/PLA2G4F/GP6/PRKACB/RASGRP2/PLA2G4A/P2RY12/SNAP23/MAPK3/STIM1/ITPR1/ARHGEF1	13
KEGG	hsa04910	Insulin signaling pathway	14/532	137/8135	0.06347	0.6573	0.6423	TSC2/ARAF/PIK3CB/PRKAR2A/PRKACB/ELK1/CRK/PCK2/MAPK3/MAPK9/PRKAR1A/PRKAG1/CALM1/SH2B2	14
KEGG	hsa04670	Leukocyte transendothelial migration	12/532	114/8135	0.06842	0.6612	0.6462	RAPGEF3/PIK3CB/CLDN24/PRKCG/MYL2/ITK/CD99L2/CTNNA1/VCL/CLDN14/NCF4/MYL5	12
KEGG	hsa04914	Progesterone-mediated oocyte maturation	11/532	102/8135	0.0687	0.6612	0.6462	ARAF/PIK3CB/AURKA/ANAPC13/PRKACB/SPDYE2/SPDYE3/CDC27/MAPK3/ANAPC7/MAPK9	11
KEGG	hsa04340	Hedgehog signaling pathway	7/532	56/8135	0.07102	0.6612	0.6462	LRP2/CSNK1E/PRKACB/CSNK1A1/BTRC/HHAT/ARRB1	7
KEGG	hsa04726	Serotonergic synapse	12/532	115/8135	0.0721	0.6612	0.6462	ARAF/RAPGEF3/PLA2G4F/PRKCG/PRKACB/PLA2G4A/DUSP1/HTR6/MAPK3/CACNA1B/ITPR1/TPH2	12
KEGG	hsa00230	Purine metabolism	13/532	128/8135	0.07471	0.6653	0.6501	PAICS/ENTPD2/ENTPD5/PDE8B/GART/PAPSS2/NT5E/NT5C2/PDE6D/PDE7B/NT5C/PRPS1L1/PFAS	13
KEGG	hsa04140	Autophagy - animal	14/532	141/8135	0.07669	0.6653	0.6501	TSC2/PIK3CB/RRAGD/PRKACB/CTSB/DAPK1/AMBRA1/MAPK3/MAPK9/HIF1A/ITPR1/PPP2CA/IGBP1/ATG4A	14
KEGG	hsa04934	Cushing syndrome	15/532	155/8135	0.08159	0.6752	0.6598	RASD1/PRKACB/FZD9/CREB3L3/CREB3L4/PDE8B/MAPK3/CRHR1/CCNE1/TCF7/ITPR1/HSD3B1/ATF6B/CYP11B1/CDKN1A	15
KEGG	hsa05213	Endometrial cancer	7/532	58/8135	0.08251	0.6752	0.6598	ARAF/PIK3CB/ELK1/CTNNA1/MAPK3/TCF7/CDKN1A	7
KEGG	hsa04330	Notch signaling pathway	7/532	59/8135	0.08864	0.6752	0.6598	DTX1/MAML3/MAML2/DTX3L/ATXN1/MAML1/HES5	7
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	5/532	37/8135	0.091	0.6752	0.6598	PIK3CB/SLC9A3R2/PRKCG/NEDD4L/MAPK3	5
KEGG	hsa00450	Selenocompound metabolism	3/532	17/8135	0.09546	0.6752	0.6598	TXNRD1/INMT/PAPSS2	3
KEGG	hsa04270	Vascular smooth muscle contraction	13/532	134/8135	0.09853	0.6752	0.6598	ARAF/MYLK2/PLA2G4F/PRKCG/PRKACB/PLA2G4A/PLA2G2D/RAMP1/MAPK3/AVPR1B/CALM1/ITPR1/ARHGEF1	13
KEGG	hsa00140	Steroid hormone biosynthesis	7/532	61/8135	0.1016	0.6752	0.6598	CYP1A2/HSD17B7/HSD3B1/UGT2B11/LRTOMT/CYP11B1/UGT1A6	7
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	10/532	98/8135	0.1063	0.6752	0.6598	PIK3CB/NTRK1/PTGER2/PLA2G4F/PRKCG/PRKACB/PLA2G4A/MAPK9/CALM1/ITPR1	10
KEGG	hsa04925	Aldosterone synthesis and secretion	10/532	98/8135	0.1063	0.6752	0.6598	DAGLA/PRKCG/PRKACB/CREB3L3/CREB3L4/CALM1/PRKD1/ITPR1/HSD3B1/ATF6B	10
KEGG	hsa05226	Gastric cancer	14/532	149/8135	0.1081	0.6752	0.6598	ARAF/RXRB/PIK3CB/SMAD2/TERT/FGF3/FZD9/CSNK1A1/CTNNA1/MAPK3/CCNE1/TCF7/FGF22/CDKN1A	14
KEGG	hsa05161	Hepatitis B	15/532	162/8135	0.1084	0.6752	0.6598	ARAF/PIK3CB/PRKCG/ELK1/CREB3L3/CREB3L4/FOS/IFNA4/IKBKE/MAPK3/MAPK9/CCNE1/ATF6B/TAB1/CDKN1A	15
KEGG	hsa04668	TNF signaling pathway	11/532	112/8135	0.1143	0.6752	0.6598	PIK3CB/CCL20/CX3CL1/MMP14/CREB3L3/CREB3L4/FOS/MAPK3/MAPK9/ATF6B/TAB1	11
KEGG	hsa01230	Biosynthesis of amino acids	8/532	75/8135	0.1154	0.6752	0.6598	MAT2B/PYCR1/GPT/GLUL/PGAM2/MAT1A/PRPS1L1/CPS1	8
KEGG	hsa04915	Estrogen signaling pathway	13/532	138/8135	0.1167	0.6752	0.6598	PIK3CB/KRT26/PRKACB/CREB3L3/CREB3L4/FOS/KRT16/HBEGF/MAPK3/CALM1/ITPR1/ATF6B/NCOA2	13
KEGG	hsa00591	Linoleic acid metabolism	4/532	29/8135	0.1178	0.6752	0.6598	PLA2G4F/PLA2G4A/CYP1A2/PLA2G2D	4
KEGG	hsa04725	Cholinergic synapse	11/532	113/8135	0.1196	0.6752	0.6598	KCNQ2/PIK3CB/PRKCG/PRKACB/CREB3L3/CREB3L4/FOS/MAPK3/CACNA1B/CHRM1/ITPR1	11
KEGG	hsa04971	Gastric acid secretion	8/532	76/8135	0.1221	0.6752	0.6598	MYLK2/SLC9A4/PRKCG/PRKACB/GAST/CALM1/SSTR2/ITPR1	8
KEGG	hsa04929	GnRH secretion	7/532	64/8135	0.123	0.6752	0.6598	PIK3CB/KISS1/PRKCG/MAPK3/ITPR1/ARRB1/TRPC5	7
KEGG	hsa04014	Ras signaling pathway	20/532	232/8135	0.1237	0.6752	0.6598	RGL1/PIK3CB/BRAP/NTRK1/PLA2G4F/PRKCG/FGF3/PRKACB/RASGRP2/ELK1/PLA2G4A/NTF3/PLCE1/PLA2G2D/ETS1/MAPK3/MAPK9/CALM1/FGF22/PAK3	20
KEGG	hsa01240	Biosynthesis of cofactors	14/532	153/8135	0.1264	0.6752	0.6598	IDO1/MAT2B/CTPS2/RDH13/ALAS1/GGH/PANK3/COX15/ALDH1B1/MAT1A/UGT2B11/ALPL/UGT1A6/GCLM	14
KEGG	hsa03440	Homologous recombination	5/532	41/8135	0.1271	0.6752	0.6598	POLD1/RPA4/XRCC2/PALB2/XRCC3	5
KEGG	hsa05131	Shigellosis	21/532	247/8135	0.1295	0.6752	0.6598	PIK3CB/RRAGD/UBE2NL/UBE2D1/MYL2/ELMO2/CRK/PLCE1/NLRP3/UBE2D3/BTRC/MAPK3/MAPK9/UBE2N/TECPR1/VCL/ITPR1/ACTR3B/MALT1/TAB1/MYL5	21
KEGG	hsa04310	Wnt signaling pathway	15/532	167/8135	0.1305	0.6752	0.6598	CTNNBIP1/CBY1/CSNK1E/PRKCG/PRKACB/FZD9/CSNK1A1/BTRC/RUVBL1/MAPK9/CHD8/TCF7/NKD2/SENP2/DAAM1	15
KEGG	hsa04974	Protein digestion and absorption	10/532	103/8135	0.1351	0.6752	0.6598	COL16A1/COL11A2/CPB2/COL4A1/COL23A1/COL9A1/MEP1A/COL5A1/COL8A2/CPA3	10
KEGG	hsa05225	Hepatocellular carcinoma	15/532	168/8135	0.1352	0.6752	0.6598	TXNRD1/ARAF/PIK3CB/SMAD2/TERT/PRKCG/MGST1/ELK1/FZD9/GSTA2/CSNK1A1/MAPK3/BRD7/TCF7/CDKN1A	15
KEGG	hsa04926	Relaxin signaling pathway	12/532	129/8135	0.1369	0.6752	0.6598	PIK3CB/SMAD2/COL4A1/PRKACB/CREB3L3/CREB3L4/FOS/MAPK3/MAPK9/RXFP3/ATF6B/ARRB1	12
KEGG	hsa05132	Salmonella infection	21/532	249/8135	0.1372	0.6752	0.6598	BRK1/PIK3CB/DYNC2LI1/MYL2/ELMO2/SNX9/FOS/KLC2/NLRP3/DCTN5/VPS18/MAPK3/ACBD3/MAPK9/TCF7/CYFIP1/ACTR3B/SNX18/TAB1/PAK3/MYL5	21
KEGG	hsa00670	One carbon pool by folate	3/532	20/8135	0.1389	0.6752	0.6598	MTFMT/ALDH1L1/GART	3
KEGG	hsa05032	Morphine addiction	9/532	91/8135	0.1394	0.6752	0.6598	SLC32A1/GABRE/PRKCG/PRKACB/PDE8B/ADORA1/CACNA1B/PDE7B/ARRB1	9
KEGG	hsa04625	C-type lectin receptor signaling pathway	10/532	104/8135	0.1414	0.6752	0.6598	PIK3CB/NLRP3/IKBKE/MAPK3/MAPK9/CLEC6A/CALM1/ITPR1/MALT1/CD209	10
KEGG	hsa04390	Hippo signaling pathway	14/532	157/8135	0.1463	0.6752	0.6598	CSNK1E/SMAD2/LLGL2/FZD9/BTRC/YWHAE/CTNNA1/TCF7/NKD2/PPP2CA/YWHAH/BMP8B/PPP2R2C/TP53BP2	14
KEGG	hsa04720	Long-term potentiation	7/532	67/8135	0.1464	0.6752	0.6598	ARAF/RAPGEF3/PRKCG/PRKACB/MAPK3/CALM1/ITPR1	7
KEGG	hsa00860	Porphyrin metabolism	5/532	43/8135	0.1472	0.6752	0.6598	ALAS1/COX15/HEPHL1/UGT2B11/UGT1A6	5
KEGG	hsa00770	Pantothenate and CoA biosynthesis	3/532	21/8135	0.1546	0.6893	0.6736	PANK3/ALDH1B1/DPYD	3
KEGG	hsa00830	Retinol metabolism	7/532	68/8135	0.1546	0.6893	0.6736	ADH4/RDH13/CYP1A2/ALDH1A3/UGT2B11/RDH8/UGT1A6	7
KEGG	hsa04962	Vasopressin-regulated water reabsorption	5/532	44/8135	0.1578	0.6939	0.6781	DYNC2LI1/PRKACB/CREB3L3/CREB3L4/DCTN5	5
KEGG	hsa04350	TGF-beta signaling pathway	9/532	94/8135	0.1602	0.695	0.6792	SMAD2/ID3/MAPK3/INHBA/RGMB/PPP2CA/BMP8B/ACVR1/DCN	9
KEGG	hsa03410	Base excision repair	4/532	33/8135	0.1664	0.7123	0.696	POLL/APEX1/POLD1/MUTYH	4
KEGG	hsa00240	Pyrimidine metabolism	6/532	58/8135	0.1766	0.7221	0.7056	CTPS2/ENTPD5/NT5E/NT5C2/DPYD/NT5C	6
KEGG	hsa00480	Glutathione metabolism	6/532	58/8135	0.1766	0.7221	0.7056	GGT6/GPX3/MGST1/GSTA2/GPX1/GCLM	6
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	13/532	150/8135	0.182	0.7221	0.7056	TPM3/RAPGEF3/SCN4B/MYL2/PRKACB/CREB3L3/CREB3L4/CACNG1/MAPK3/CALM1/PPP2CA/ATF6B/PPP2R2C	13
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	9/532	97/8135	0.1824	0.7221	0.7056	PIK3CB/PLA2G4F/PRKCG/FCGR2B/PLA2G4A/CRK/MAPK3/ACTR3B/AMPH	9
KEGG	hsa04713	Circadian entrainment	9/532	97/8135	0.1824	0.7221	0.7056	GRIA4/RASD1/PRKCG/PRKACB/FOS/MAPK3/CALM1/ITPR1/PER3	9
KEGG	hsa05215	Prostate cancer	9/532	97/8135	0.1824	0.7221	0.7056	ARAF/PIK3CB/CREB3L3/CREB3L4/KLK3/MAPK3/CCNE1/TCF7/CDKN1A	9
KEGG	hsa05205	Proteoglycans in cancer	17/532	205/8135	0.1854	0.7221	0.7056	ARAF/PIK3CB/SMAD2/PRKCG/PRKACB/ELK1/FZD9/PLCE1/GPC1/NUDT16L1/HBEGF/MAPK3/HIF1A/ITPR1/ARHGEF1/DCN/CDKN1A	17
KEGG	hsa00982	Drug metabolism - cytochrome P450	7/532	72/8135	0.1896	0.7221	0.7056	ADH4/MGST1/CYP1A2/GSTA2/FMO5/UGT2B11/UGT1A6	7
KEGG	hsa01522	Endocrine resistance	9/532	98/8135	0.1901	0.7221	0.7056	ARAF/PIK3CB/MED1/PRKACB/FOS/HBEGF/MAPK3/MAPK9/CDKN1A	9
KEGG	hsa00620	Pyruvate metabolism	5/532	47/8135	0.1912	0.7221	0.7056	ADH4/GRHPR/ALDH1B1/PCK2/GLO1	5
KEGG	hsa00562	Inositol phosphate metabolism	7/532	73/8135	0.1988	0.7343	0.7176	ITPKB/PIK3CB/IPPK/FIG4/PLCE1/MINPP1/SYNJ1	7
KEGG	hsa05210	Colorectal cancer	8/532	86/8135	0.199	0.7343	0.7176	ARAF/PIK3CB/SMAD2/FOS/MAPK3/MAPK9/TCF7/CDKN1A	8
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/532	24/8135	0.2047	0.7382	0.7214	GLCE/EXT1/B3GAT3	3
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	4/532	36/8135	0.2068	0.7382	0.7214	NNMT/NT5E/NT5C2/NT5C	4
KEGG	hsa04921	Oxytocin signaling pathway	13/532	154/8135	0.207	0.7382	0.7214	MYLK2/PLA2G4F/PRKCG/PRKACB/ELK1/PLA2G4A/FOS/CACNG1/MAPK3/PRKAG1/CALM1/ITPR1/CDKN1A	13
KEGG	hsa04010	MAPK signaling pathway	23/532	294/8135	0.212	0.748	0.7309	ARAF/NTRK1/PLA2G4F/PRKCG/FGF3/PRKACB/RASGRP2/ELK1/PLA2G4A/ELK4/CRK/NTF3/FOS/DUSP1/LAMTOR3/CACNG1/MAPK3/CACNA1B/MAPK9/PPM1B/FGF22/ARRB1/TAB1	23
KEGG	hsa05030	Cocaine addiction	5/532	49/8135	0.2147	0.7493	0.7322	PRKACB/CREB3L3/CREB3L4/GPSM1/ATF6B	5
KEGG	hsa04150	mTOR signaling pathway	13/532	156/8135	0.22	0.7521	0.7349	TSC2/PIK3CB/RRAGD/PRKCG/WDR24/FZD9/ATP6V1H/LAMTOR3/ATP6V1E1/MAPK3/CAB39/TELO2/LPIN1	13
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/532	25/8135	0.2221	0.7521	0.7349	PLA2G4F/PLA2G4A/PLA2G2D	3
KEGG	hsa04211	Longevity regulating pathway	8/532	89/8135	0.2253	0.7521	0.7349	TSC2/PIK3CB/CAT/PRKACB/CREB3L3/CREB3L4/PRKAG1/ATF6B	8
KEGG	hsa04151	PI3K-Akt signaling pathway	27/532	354/8135	0.2267	0.7521	0.7349	TSC2/PIK3CB/TNR/COL4A1/NTRK1/GH1/FGF3/PHLPP1/CREB3L3/CREB3L4/NTF3/IFNA4/COL9A1/LAMC2/YWHAE/PCK2/MAPK3/CSH1/CCNE1/CHRM1/FGF22/PPP2CA/YWHAH/ATF6B/LAMA4/PPP2R2C/CDKN1A	27
KEGG	hsa05212	Pancreatic cancer	7/532	76/8135	0.2275	0.7521	0.7349	ARAF/PIK3CB/SMAD2/ARHGEF6/MAPK3/MAPK9/CDKN1A	7
KEGG	hsa04068	FoxO signaling pathway	11/532	131/8135	0.2371	0.7521	0.7349	ARAF/PIK3CB/CAT/CSNK1E/PCK2/MAPK3/CCNG2/MAPK9/PRKAG1/SETD7/CDKN1A	11
KEGG	hsa04620	Toll-like receptor signaling pathway	9/532	104/8135	0.2391	0.7521	0.7349	PIK3CB/CD40/FOS/IFNA4/CD86/IKBKE/MAPK3/MAPK9/TAB1	9
KEGG	hsa00330	Arginine and proline metabolism	5/532	51/8135	0.2391	0.7521	0.7349	PYCR1/ALDH4A1/PRODH/ALDH1B1/GAMT	5
KEGG	hsa04913	Ovarian steroidogenesis	5/532	51/8135	0.2391	0.7521	0.7349	PLA2G4F/PRKACB/PLA2G4A/HSD17B7/HSD3B1	5
KEGG	hsa00790	Folate biosynthesis	3/532	26/8135	0.2399	0.7521	0.7349	GGH/ALPL/TPH2	3
KEGG	hsa04510	Focal adhesion	16/532	201/8135	0.2413	0.7521	0.7349	PIK3CB/TNR/MYLK2/COL4A1/PRKCG/MYL2/ELK1/CRK/COL9A1/LAMC2/MAPK3/MAPK9/VCL/LAMA4/PAK3/MYL5	16
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/532	15/8135	0.2568	0.7711	0.7535	ST8SIA1/B4GALNT1	2
KEGG	hsa00730	Thiamine metabolism	2/532	15/8135	0.2568	0.7711	0.7535	THTPA/ALPL	2
KEGG	hsa04152	AMPK signaling pathway	10/532	120/8135	0.2587	0.7711	0.7535	TSC2/PIK3CB/PFKFB2/CREB3L3/CREB3L4/PCK2/CAB39/PRKAG1/PPP2CA/PPP2R2C	10
KEGG	hsa04810	Regulation of actin cytoskeleton	17/532	218/8135	0.259	0.7711	0.7535	BRK1/ARAF/PIK3CB/MYLK2/FGF3/MYL2/ARHGEF6/CRK/MAPK3/CHRM1/VCL/FGF22/CYFIP1/ACTR3B/ARHGEF1/PAK3/MYL5	17
KEGG	hsa05323	Rheumatoid arthritis	8/532	93/8135	0.2621	0.7711	0.7535	CCL20/ATP6V0E1/ATP6V1H/FOS/CD86/ATP6V1E1/TNFRSF11A/ACP5	8
KEGG	hsa00260	Glycine, serine and threonine metabolism	4/532	40/8135	0.2642	0.7711	0.7535	GRHPR/PGAM2/ALAS1/GAMT	4
KEGG	hsa05033	Nicotine addiction	4/532	40/8135	0.2642	0.7711	0.7535	GRIA4/SLC32A1/GABRE/CACNA1B	4
KEGG	hsa04657	IL-17 signaling pathway	8/532	94/8135	0.2716	0.7851	0.7672	CCL20/CCL11/FOS/IKBKE/MAPK3/MAPK9/MUC5B/IL17RC	8
KEGG	hsa03013	Nucleocytoplasmic transport	9/532	108/8135	0.2739	0.7851	0.7672	UPF2/GLE1/KPNA6/RANGAP1/ACIN1/UBE2I/SENP2/NXF3/SUMO3	9
KEGG	hsa04024	cAMP signaling pathway	17/532	221/8135	0.2774	0.7864	0.7685	GRIA4/RAPGEF3/PIK3CB/PTGER2/PRKACB/CREB3L3/CREB3L4/FOS/PLCE1/ADORA1/HTR6/MAPK3/CRHR1/MAPK9/CHRM1/CALM1/SSTR2	17
KEGG	hsa05202	Transcriptional misregulation in cancer	15/532	193/8135	0.2804	0.7864	0.7685	RUNX1/RXRB/NTRK1/NR4A3/PAX8/ELK4/CD40/ETV6/CD86/BMP2K/MAF/NFKBIZ/PRCC/CDKN1A/PBX3	15
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/532	16/8135	0.2817	0.7864	0.7685	GGT6/FMO5	2
KEGG	hsa04924	Renin secretion	6/532	69/8135	0.2958	0.8186	0.8	PTGER2/PRKACB/CTSB/ADORA1/CALM1/ITPR1	6
KEGG	hsa04070	Phosphatidylinositol signaling system	8/532	97/8135	0.3005	0.8222	0.8035	ITPKB/PIK3CB/IPPK/PRKCG/PLCE1/CALM1/ITPR1/SYNJ1	8
KEGG	hsa05163	Human cytomegalovirus infection	17/532	225/8135	0.3027	0.8222	0.8035	TSC2/PIK3CB/CX3CL1/PTGER2/PRKCG/PRKACB/ELK1/CREB3L3/CRK/CREB3L4/IFNA4/MAPK3/CALM1/ITPR1/ATF6B/ARHGEF1/CDKN1A	17
KEGG	hsa00120	Primary bile acid biosynthesis	2/532	17/8135	0.3066	0.8222	0.8035	HSD17B4/CYP39A1	2
KEGG	hsa05230	Central carbon metabolism in cancer	6/532	70/8135	0.3075	0.8222	0.8035	SLC16A3/PIK3CB/NTRK1/PGAM2/MAPK3/HIF1A	6
KEGG	hsa00564	Glycerophospholipid metabolism	8/532	98/8135	0.3104	0.8222	0.8035	CHKA/PLA2G4F/ETNK1/PLA2G4A/PLA2G2D/GPD1/GPD1L/LPIN1	8
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/532	30/8135	0.3125	0.8222	0.8035	ALDH1B1/UGT2B11/UGT1A6	3
KEGG	hsa04610	Complement and coagulation cascades	7/532	85/8135	0.3203	0.83	0.811	C1S/C7/CPB2/CD55/PLG/F7/F5	7
KEGG	hsa04380	Osteoclast differentiation	10/532	128/8135	0.3267	0.83	0.811	PIK3CB/FCGR2B/FOS/MAPK3/MAPK9/TNFRSF11A/NCF4/TAB1/FHL2/ACP5	10
KEGG	hsa04141	Protein processing in endoplasmic reticulum	13/532	171/8135	0.3272	0.83	0.811	MAN1B1/UBE2D1/SEC31A/UBE2D3/MAPK9/SSR3/NSFL1C/SSR2/ATF6B/UBE4B/RNF185/SIL1/LMAN1	13
KEGG	hsa05160	Hepatitis C	12/532	157/8135	0.3301	0.83	0.811	ARAF/PIK3CB/CLDN24/IFNA4/IKBKE/YWHAE/MAPK3/CLDN14/PPP2CA/YWHAH/PPP2R2C/CDKN1A	12
KEGG	hsa05218	Melanoma	6/532	72/8135	0.3309	0.83	0.811	ARAF/PIK3CB/FGF3/MAPK3/FGF22/CDKN1A	6
KEGG	hsa05223	Non-small cell lung cancer	6/532	72/8135	0.3309	0.83	0.811	ARAF/RXRB/PIK3CB/PRKCG/MAPK3/CDKN1A	6
KEGG	hsa01200	Carbon metabolism	9/532	115/8135	0.338	0.8336	0.8146	SDHB/CAT/GPT/GLUD2/PGAM2/PGP/PRPS1L1/PCCB/CPS1	9
KEGG	hsa04916	Melanogenesis	8/532	101/8135	0.3402	0.8336	0.8146	PRKCG/PRKACB/FZD9/CREB3L3/CREB3L4/MAPK3/TCF7/CALM1	8
KEGG	hsa04370	VEGF signaling pathway	5/532	59/8135	0.3423	0.8336	0.8146	PIK3CB/PLA2G4F/PRKCG/PLA2G4A/MAPK3	5
KEGG	hsa04115	p53 signaling pathway	6/532	73/8135	0.3428	0.8336	0.8146	TSC2/TP53AIP1/AIFM2/CCNG2/CCNE1/CDKN1A	6
KEGG	hsa04136	Autophagy - other	3/532	32/8135	0.3492	0.8427	0.8235	PPP2CA/IGBP1/ATG4A	3
KEGG	hsa04930	Type II diabetes mellitus	4/532	46/8135	0.3546	0.8465	0.8272	PIK3CB/MAPK3/CACNA1B/MAPK9	4
KEGG	hsa05224	Breast cancer	11/532	147/8135	0.3665	0.8465	0.8272	ARAF/PIK3CB/FGF3/FZD9/FOS/CSNK1A1/MAPK3/TCF7/FGF22/HES5/CDKN1A	11
KEGG	hsa05214	Glioma	6/532	75/8135	0.3665	0.8465	0.8272	ARAF/PIK3CB/PRKCG/MAPK3/CALM1/CDKN1A	6
KEGG	hsa00590	Arachidonic acid metabolism	5/532	61/8135	0.3688	0.8465	0.8272	GPX3/PLA2G4F/PLA2G4A/PLA2G2D/GPX1	5
KEGG	hsa04064	NF-kappa B signaling pathway	8/532	104/8135	0.3704	0.8465	0.8272	CD40/CCL19/UBE2I/CARD10/TNFRSF11A/MALT1/TAB1/TNFRSF13C	8
KEGG	hsa04060	Cytokine-cytokine receptor interaction	21/532	295/8135	0.3748	0.8465	0.8272	CCL20/TNFRSF19/CX3CL1/GH1/CCL11/CD40/IFNA4/IL24/IL26/CSF2RA/TNFRSF8/GDF1/CCL19/CSH1/INHBA/IL36B/TNFRSF11A/BMP8B/ACVR1/IL17RC/TNFRSF13C	21
KEGG	hsa04723	Retrograde endocannabinoid signaling	11/532	148/8135	0.3749	0.8465	0.8272	GRIA4/SLC32A1/DAGLA/GABRE/PRKCG/PRKACB/NDUFA9/MAPK3/CACNA1B/MAPK9/ITPR1	11
KEGG	hsa04722	Neurotrophin signaling pathway	9/532	119/8135	0.3757	0.8465	0.8272	PIK3CB/NTRK1/CRK/NTF3/YWHAE/MAPK3/MAPK9/CALM1/SH2B2	9
KEGG	hsa05133	Pertussis	6/532	76/8135	0.3785	0.8465	0.8272	C1S/FOS/NLRP3/MAPK3/MAPK9/CALM1	6
KEGG	hsa05220	Chronic myeloid leukemia	6/532	76/8135	0.3785	0.8465	0.8272	RUNX1/ARAF/PIK3CB/CRK/MAPK3/CDKN1A	6
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/532	20/8135	0.3797	0.8465	0.8272	CSGALNACT2/B3GAT3	2
KEGG	hsa00280	Valine, leucine and isoleucine degradation	4/532	48/8135	0.3849	0.8489	0.8295	BCKDHB/MCCC2/ALDH1B1/PCCB	4
KEGG	hsa05100	Bacterial invasion of epithelial cells	6/532	77/8135	0.3904	0.8489	0.8295	PIK3CB/ELMO2/CRK/CTNNA1/VCL/ACTR3B	6
KEGG	hsa04658	Th1 and Th2 cell differentiation	7/532	92/8135	0.3963	0.8489	0.8295	MAML3/FOS/MAPK3/MAPK9/MAF/MAML2/MAML1	7
KEGG	hsa05222	Small cell lung cancer	7/532	92/8135	0.3963	0.8489	0.8295	RXRB/PIK3CB/COL4A1/LAMC2/CCNE1/LAMA4/CDKN1A	7
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	4/532	49/8135	0.4	0.8489	0.8295	GNPDA1/CMAS/NPL/AMDHD2	4
KEGG	hsa04922	Glucagon signaling pathway	8/532	107/8135	0.4008	0.8489	0.8295	PRKACB/PGAM2/CREB3L3/CREB3L4/PCK2/PRKAG1/CALM1/ITPR1	8
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/532	78/8135	0.4023	0.8489	0.8295	ADH4/MGST1/CYP1A2/GSTA2/UGT2B11/UGT1A6	6
KEGG	hsa04721	Synaptic vesicle cycle	6/532	78/8135	0.4023	0.8489	0.8295	SLC32A1/ATP6V0E1/ATP6V1H/STXBP1/ATP6V1E1/CACNA1B	6
KEGG	hsa05135	Yersinia infection	10/532	137/8135	0.4069	0.8489	0.8295	PIK3CB/ELMO2/CRK/FOS/NLRP3/MAPK3/MAPK9/ACTR3B/ARHGEF1/TAB1	10
KEGG	hsa04970	Salivary secretion	7/532	93/8135	0.4073	0.8489	0.8295	LYZL1/DMBT1/PRKCG/PRKACB/CALM1/ITPR1/MUC5B	7
KEGG	hsa05130	Pathogenic Escherichia coli infection	14/532	197/8135	0.4134	0.853	0.8336	BRK1/MYO5B/CLDN24/MYO5C/FOS/NLRP3/MAPK3/MAPK9/CLDN14/CYFIP1/ACTR3B/ARHGEF1/TAB1/PAK3	14
KEGG	hsa05110	Vibrio cholerae infection	4/532	50/8135	0.4151	0.853	0.8336	ATP6V0E1/PRKACB/ATP6V1H/ATP6V1E1	4
KEGG	hsa03030	DNA replication	3/532	36/8135	0.4216	0.853	0.8336	POLD1/RPA4/PRIM2	3
KEGG	hsa05418	Fluid shear stress and atherosclerosis	10/532	139/8135	0.4248	0.853	0.8336	PIK3CB/MGST1/GSTA2/FOS/DUSP1/GPC1/MAPK9/CALM1/ACVR1/SUMO3	10
KEGG	hsa00900	Terpenoid backbone biosynthesis	2/532	22/8135	0.4267	0.853	0.8336	RCE1/ICMT	2
KEGG	hsa04530	Tight junction	12/532	169/8135	0.4271	0.853	0.8336	RUNX1/CLDN24/MYL2/LLGL2/PRKACB/NEDD4L/MAPK9/PRKAG1/CLDN14/ACTR3B/PPP2CA/PPP2R2C	12
KEGG	hsa05417	Lipid and atherosclerosis	15/532	215/8135	0.4361	0.853	0.8336	RXRB/PIK3CB/CD40/FOS/IFNA4/CASP6/NLRP3/IKBKE/MAPK3/MAPK9/CALM1/ITPR1/NCF4/ARHGEF1/TAB1	15
KEGG	hsa05143	African trypanosomiasis	3/532	37/8135	0.4393	0.853	0.8336	IDO1/PRKCG/LAMA4	3
KEGG	hsa04110	Cell cycle	9/532	126/8135	0.4422	0.853	0.8336	SMAD2/ANAPC13/CDC6/CDC27/YWHAE/ANAPC7/CCNE1/YWHAH/CDKN1A	9
KEGG	hsa00010	Glycolysis / Gluconeogenesis	5/532	67/8135	0.448	0.853	0.8336	ADH4/PGAM2/ALDH1B1/MINPP1/PCK2	5
KEGG	hsa05221	Acute myeloid leukemia	5/532	67/8135	0.448	0.853	0.8336	RUNX1/ARAF/PIK3CB/MAPK3/TCF7	5
KEGG	hsa03430	Mismatch repair	2/532	23/8135	0.4495	0.853	0.8336	POLD1/RPA4	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/532	23/8135	0.4495	0.853	0.8336	GLUD2/PCK2	2
KEGG	hsa04662	B cell receptor signaling pathway	6/532	82/8135	0.4497	0.853	0.8336	PIK3CB/CD72/FCGR2B/FOS/MAPK3/MALT1	6
KEGG	hsa03015	mRNA surveillance pathway	7/532	97/8135	0.4508	0.853	0.8336	UPF2/GLE1/CPSF2/ACIN1/NXF3/PPP2CA/PPP2R2C	7
KEGG	hsa04936	Alcoholic liver disease	10/532	142/8135	0.4518	0.853	0.8336	ADH4/IFNA4/IKBKE/ALDH1B1/MAPK9/TCF7/PRKAG1/IL17RC/TAB1/LPIN1	10
KEGG	hsa05340	Primary immunodeficiency	3/532	38/8135	0.4568	0.8553	0.8359	CD40/DCLRE1C/TNFRSF13C	3
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/532	143/8135	0.4607	0.8553	0.8359	PIK3CB/SMAD2/FZD9/ID3/MAPK3/INHBA/TCF7/OTX1/ACVR1/POU5F1	10
KEGG	hsa04664	Fc epsilon RI signaling pathway	5/532	68/8135	0.461	0.8553	0.8359	PIK3CB/PLA2G4F/PLA2G4A/MAPK3/MAPK9	5
KEGG	hsa04977	Vitamin digestion and absorption	2/532	24/8135	0.4717	0.8631	0.8435	BTD/TCN2	2
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	5/532	69/8135	0.4739	0.8631	0.8435	MGST1/CYP1A2/GSTA2/UGT2B11/UGT1A6	5
KEGG	hsa03460	Fanconi anemia pathway	4/532	54/8135	0.4743	0.8631	0.8435	RPA4/PALB2/TELO2/FANCL	4
KEGG	hsa04144	Endocytosis	17/532	251/8135	0.477	0.8631	0.8435	VPS45/PDCD6IP/CHMP7/SMAD2/GRK1/AGAP3/VTA1/CHMP1A/NEDD4L/VPS37D/RNF41/ARFGAP1/IQSEC2/ACTR3B/ARRB1/ACAP2/AMPH	17
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/532	100/8135	0.483	0.8631	0.8435	PIK3CB/SMAD2/COL4A1/EGR1/PLCE1/MAPK3/MAPK9	7
KEGG	hsa01232	Nucleotide metabolism	6/532	85/8135	0.4848	0.8631	0.8435	ENTPD2/CTPS2/ENTPD5/NT5E/NT5C2/NT5C	6
KEGG	hsa04917	Prolactin signaling pathway	5/532	70/8135	0.4867	0.8631	0.8435	PIK3CB/FOS/MAPK3/MAPK9/TNFRSF11A	5
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/532	70/8135	0.4867	0.8631	0.8435	ATP6V0E1/ATP6V1H/ATP6V1E1/HBEGF/MAPK9	5
KEGG	hsa00920	Sulfur metabolism	1/532	10/8135	0.4917	0.8641	0.8445	PAPSS2	1
KEGG	hsa04911	Insulin secretion	6/532	86/8135	0.4963	0.8641	0.8445	PRKCG/PRKACB/CREB3L3/CREB3L4/FFAR1/ATF6B	6
KEGG	hsa04520	Adherens junction	5/532	71/8135	0.4994	0.8641	0.8445	FARP2/CTNNA1/MAPK3/TCF7/VCL	5
KEGG	hsa05142	Chagas disease	7/532	102/8135	0.5043	0.8641	0.8445	PIK3CB/SMAD2/FOS/MAPK3/MAPK9/PPP2CA/PPP2R2C	7
KEGG	hsa05146	Amoebiasis	7/532	102/8135	0.5043	0.8641	0.8445	PIK3CB/COL4A1/PRKCG/PRKACB/LAMC2/VCL/LAMA4	7
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/532	194/8135	0.5056	0.8641	0.8445	PIK3CB/FOS/IFNA4/CD86/ZFP36/IKBKE/MAPK3/MAPK9/TCF7/CALM1/HIF1A/ITPR1/CDKN1A	13
KEGG	hsa04020	Calcium signaling pathway	16/532	240/8135	0.5061	0.8641	0.8445	ITPKB/MYLK2/NTRK1/PRKCG/FGF3/PRKACB/PLCE1/HTR6/AVPR1B/CACNA1B/CHRM1/CALM1/P2RX5/FGF22/STIM1/ITPR1	16
KEGG	hsa04137	Mitophagy - animal	5/532	72/8135	0.5119	0.8647	0.845	FIS1/AMBRA1/MAPK9/HIF1A/RHOT1	5
KEGG	hsa04514	Cell adhesion molecules	10/532	149/8135	0.5137	0.8647	0.845	NFASC/CLDN24/CD99L2/CD40/CD86/PVR/NLGN2/CD276/CLDN14/CDH2	10
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/532	26/8135	0.5145	0.8647	0.845	PIGZ/PIGY	2
KEGG	hsa04512	ECM-receptor interaction	6/532	88/8135	0.5191	0.8678	0.8481	TNR/COL4A1/GP6/COL9A1/LAMC2/LAMA4	6
KEGG	hsa01524	Platinum drug resistance	5/532	73/8135	0.5244	0.8678	0.8481	PIK3CB/MGST1/GSTA2/MAPK3/CDKN1A	5
KEGG	hsa04660	T cell receptor signaling pathway	7/532	104/8135	0.5252	0.8678	0.8481	PIK3CB/ITK/FOS/MAPK3/MAPK9/MALT1/PAK3	7
KEGG	hsa04727	GABAergic synapse	6/532	89/8135	0.5303	0.8678	0.8481	SLC32A1/GABRE/PRKCG/GLUL/PRKACB/CACNA1B	6
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	2/532	27/8135	0.5351	0.8678	0.8481	ELOVL3/HSD17B4	2
KEGG	hsa04966	Collecting duct acid secretion	2/532	27/8135	0.5351	0.8678	0.8481	ATP6V0E1/ATP6V1E1	2
KEGG	hsa04210	Apoptosis	9/532	136/8135	0.5353	0.8678	0.8481	PIK3CB/NTRK1/CTSB/FOS/CASP6/TP53AIP1/MAPK3/MAPK9/ITPR1	9
KEGG	hsa04371	Apelin signaling pathway	9/532	139/8135	0.5622	0.8993	0.8788	MYLK2/SMAD2/MYL2/PRKACB/EGR1/MAPK3/PRKAG1/CALM1/ITPR1	9
KEGG	hsa05162	Measles	9/532	139/8135	0.5622	0.8993	0.8788	PIK3CB/FCGR2B/SLAMF1/FOS/IFNA4/IKBKE/MAPK9/CCNE1/CD209	9
KEGG	hsa04659	Th17 cell differentiation	7/532	108/8135	0.566	0.8993	0.8788	RUNX1/RXRB/SMAD2/FOS/MAPK3/MAPK9/HIF1A	7
KEGG	hsa05140	Leishmaniasis	5/532	77/8135	0.5727	0.8993	0.8788	ELK1/FOS/MAPK3/NCF4/TAB1	5
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/532	77/8135	0.5727	0.8993	0.8788	CACNG1/CTNNA1/TCF7/CDH2/DSP	5
KEGG	hsa04218	Cellular senescence	10/532	156/8135	0.5735	0.8993	0.8788	TSC2/PIK3CB/SMAD2/ETS1/BTRC/MAPK3/CCNE1/CALM1/ITPR1/CDKN1A	10
KEGG	hsa04744	Phototransduction	2/532	29/8135	0.5743	0.8993	0.8788	GRK1/CALM1	2
KEGG	hsa04213	Longevity regulating pathway - multiple species	4/532	62/8135	0.5848	0.904	0.8834	PIK3CB/CAT/PRKACB/PRKAG1	4
KEGG	hsa00020	Citrate cycle (TCA cycle)	2/532	30/8135	0.593	0.904	0.8834	SDHB/PCK2	2
KEGG	hsa01523	Antifolate resistance	2/532	30/8135	0.593	0.904	0.8834	GGH/GART	2
KEGG	hsa05017	Spinocerebellar ataxia	9/532	143/8135	0.597	0.904	0.8834	PIK3CB/MYOD1/TRPC3/PRKCG/AMBRA1/MAPK9/PUM2/ITPR1/ATXN1	9
KEGG	hsa00310	Lysine degradation	4/532	63/8135	0.5976	0.904	0.8834	PRDM2/PRDM16/ALDH1B1/SETD7	4
KEGG	hsa04217	Necroptosis	10/532	159/8135	0.5981	0.904	0.8834	SPATA2/CHMP7/PLA2G4F/GLUD2/GLUL/CHMP1A/PLA2G4A/IFNA4/NLRP3/MAPK9	10
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/532	223/8135	0.6035	0.904	0.8834	ARAF/SDHB/PIK3CB/CAT/MGST1/NDUFA9/CYP1A2/GSTA2/FOS/MAPK3/MAPK9/PRKD1/HIF1A/COX8A	14
KEGG	hsa05150	Staphylococcus aureus infection	6/532	96/8135	0.6056	0.904	0.8834	C1S/KRT26/FCGR2B/PLG/KRT16/DEFB1	6
KEGG	hsa00983	Drug metabolism - other enzymes	5/532	80/8135	0.6072	0.904	0.8834	MGST1/GSTA2/DPYD/UGT2B11/UGT1A6	5
KEGG	hsa04062	Chemokine signaling pathway	12/532	192/8135	0.608	0.904	0.8834	PIK3CB/CCL20/GRK1/CX3CL1/CCL11/PRKACB/RASGRP2/ITK/CRK/MAPK3/CCL19/ARRB1	12
KEGG	hsa00410	beta-Alanine metabolism	2/532	31/8135	0.6111	0.904	0.8834	ALDH1B1/DPYD	2
KEGG	hsa05310	Asthma	2/532	31/8135	0.6111	0.904	0.8834	CCL11/CD40	2
KEGG	hsa00640	Propanoate metabolism	2/532	32/8135	0.6286	0.9154	0.8946	BCKDHB/PCCB	2
KEGG	hsa04146	Peroxisome	5/532	82/8135	0.6292	0.9154	0.8946	FAR2/CAT/MPV17L/CRAT/HSD17B4	5
KEGG	hsa00565	Ether lipid metabolism	3/532	49/8135	0.6303	0.9154	0.8946	PLA2G4F/PLA2G4A/PLA2G2D	3
KEGG	hsa04672	Intestinal immune network for IgA production	3/532	49/8135	0.6303	0.9154	0.8946	CD40/CD86/TNFRSF13C	3
KEGG	hsa05170	Human immunodeficiency virus 1 infection	13/532	212/8135	0.6369	0.918	0.8971	PIK3CB/PRKCG/CRK/FOS/IFNA4/BTRC/MAPK3/MAPK9/CALM1/ITPR1/TAB1/PAK3/AP1S2	13
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/532	15/8135	0.6377	0.918	0.8971	ST8SIA1	1
KEGG	hsa04360	Axon guidance	11/532	182/8135	0.6516	0.9325	0.9113	SEMA6C/PIK3CB/TRPC6/TRPC3/EPHB6/SLIT3/EFNB1/MAPK3/PAK3/TRPC5/MYL5	11
KEGG	hsa00270	Cysteine and methionine metabolism	3/532	51/8135	0.6574	0.9325	0.9113	MAT2B/MAT1A/GCLM	3
KEGG	hsa00040	Pentose and glucuronate interconversions	2/532	34/8135	0.6617	0.9325	0.9113	UGT2B11/UGT1A6	2
KEGG	hsa03020	RNA polymerase	2/532	34/8135	0.6617	0.9325	0.9113	POLR1E/POLR3B	2
KEGG	hsa04972	Pancreatic secretion	6/532	102/8135	0.6646	0.9325	0.9113	CPB2/PRKCG/PLA2G2D/RAB27B/ITPR1/CPA3	6
KEGG	hsa04071	Sphingolipid signaling pathway	7/532	119/8135	0.6688	0.9325	0.9113	PIK3CB/PRKCG/ADORA1/MAPK3/MAPK9/PPP2CA/PPP2R2C	7
KEGG	hsa04920	Adipocytokine signaling pathway	4/532	69/8135	0.6695	0.9325	0.9113	RXRB/PCK2/MAPK9/PRKAG1	4
KEGG	hsa04742	Taste transduction	5/532	86/8135	0.6711	0.9325	0.9113	GRM4/ENTPD2/PRKACB/PKD2L1/TAS2R60	5
KEGG	hsa05320	Autoimmune thyroid disease	3/532	53/8135	0.683	0.945	0.9235	CD40/IFNA4/CD86	3
KEGG	hsa00350	Tyrosine metabolism	2/532	36/8135	0.6923	0.9497	0.9281	ADH4/LRTOMT	2
KEGG	hsa00512	Mucin type O-glycan biosynthesis	2/532	36/8135	0.6923	0.9497	0.9281	GALNT12/ST6GALNAC1	2
KEGG	hsa05020	Prion disease	16/532	273/8135	0.7134	0.972	0.9499	C7/SDHB/PIK3CB/PRKACB/NDUFA9/CREB3L3/CREB3L4/EGR1/KLC2/MAPK3/CACNA1B/MAPK9/ITPR1/COX8A/NCF4/ATF6B	16
KEGG	hsa04931	Insulin resistance	6/532	108/8135	0.7177	0.972	0.9499	PIK3CB/CREB3L3/CREB3L4/PCK2/MAPK9/PRKAG1	6
KEGG	hsa04923	Regulation of lipolysis in adipocytes	3/532	56/8135	0.7187	0.972	0.9499	PIK3CB/PRKACB/ADORA1	3
KEGG	hsa05330	Allograft rejection	2/532	38/8135	0.7207	0.972	0.9499	CD40/CD86	2
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/532	19/8135	0.7238	0.9721	0.9499	GPT	1
KEGG	hsa04015	Rap1 signaling pathway	12/532	210/8135	0.7283	0.9741	0.9519	RAPGEF3/PIK3CB/PRKCG/FGF3/RASGRP2/CRK/PLCE1/FARP2/MAPK3/CALM1/PRKD1/FGF22	12
KEGG	hsa00513	Various types of N-glycan biosynthesis	2/532	39/8135	0.734	0.9777	0.9554	MAN1B1/ALG14	2
KEGG	hsa00100	Steroid biosynthesis	1/532	20/8135	0.7419	0.9795	0.9571	HSD17B7	1
KEGG	hsa05145	Toxoplasmosis	6/532	112/8135	0.7497	0.9795	0.9571	CD40/LAMC2/MAPK3/MAPK9/LAMA4/TAB1	6
KEGG	hsa05171	Coronavirus disease - COVID-19	13/532	232/8135	0.7586	0.9795	0.9571	C1S/C7/PIK3CB/PRKCG/FOS/IFNA4/RPL36A-HNRNPH2/NLRP3/HBEGF/IKBKE/MAPK3/MAPK9/RPS26	13
KEGG	hsa04072	Phospholipase D signaling pathway	8/532	148/8135	0.7608	0.9795	0.9571	GRM4/TSC2/RAPGEF3/PIK3CB/PLA2G4F/PLA2G4A/MAPK3/AVPR1B	8
KEGG	hsa05416	Viral myocarditis	3/532	60/8135	0.7614	0.9795	0.9571	CD55/CD40/CD86	3
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/532	79/8135	0.7685	0.9795	0.9571	ARAF/PIK3CB/PRKCG/MAPK3	4
KEGG	hsa03018	RNA degradation	4/532	79/8135	0.7685	0.9795	0.9571	DIS3L/XRN2/BTG2/CNOT1	4
KEGG	hsa04621	NOD-like receptor signaling pathway	10/532	184/8135	0.7723	0.9795	0.9571	ANTXR2/CTSB/IFNA4/NLRP3/IKBKE/YWHAE/MAPK3/MAPK9/ITPR1/TAB1	10
KEGG	hsa04022	cGMP-PKG signaling pathway	9/532	167/8135	0.7726	0.9795	0.9571	TRPC6/MYLK2/CREB3L3/CREB3L4/ADORA1/MAPK3/CALM1/ITPR1/ATF6B	9
KEGG	hsa00340	Histidine metabolism	1/532	22/8135	0.7746	0.9795	0.9571	ALDH1B1	1
KEGG	hsa00071	Fatty acid degradation	2/532	43/8135	0.782	0.9795	0.9571	ADH4/ALDH1B1	2
KEGG	hsa04940	Type I diabetes mellitus	2/532	43/8135	0.782	0.9795	0.9571	ICA1/CD86	2
KEGG	hsa00190	Oxidative phosphorylation	7/532	134/8135	0.7822	0.9795	0.9571	SDHB/ATP6V0E1/NDUFA9/ATP6V1H/COX15/ATP6V1E1/COX8A	7
KEGG	hsa05203	Viral carcinogenesis	11/532	204/8135	0.7887	0.9795	0.9571	PIK3CB/HDAC10/PRKACB/CREB3L3/CREB3L4/YWHAE/MAPK3/CCNE1/YWHAH/ATF6B/CDKN1A	11
KEGG	hsa04614	Renin-angiotensin system	1/532	23/8135	0.7894	0.9795	0.9571	CPA3	1
KEGG	hsa04623	Cytosolic DNA-sensing pathway	3/532	63/8135	0.7899	0.9795	0.9571	POLR3B/IFNA4/IKBKE	3
KEGG	hsa05217	Basal cell carcinoma	3/532	63/8135	0.7899	0.9795	0.9571	FZD9/TCF7/CDKN1A	3
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/532	100/8135	0.7918	0.9795	0.9571	CCL20/CX3CL1/CCL11/IL24/CCL19	5
KEGG	hsa05016	Huntington disease	17/532	306/8135	0.7933	0.9795	0.9571	GRIA4/SDHB/GPX3/HIP1/NDUFA9/CREB3L3/CREB3L4/KLC2/GPX1/AMBRA1/DCTN5/CACNA1B/MAPK9/TGM2/ITPR1/COX8A/MAP3K10	17
KEGG	hsa02010	ABC transporters	2/532	45/8135	0.8031	0.9877	0.9652	ABCA9/DEFB1	2
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	3/532	66/8135	0.8155	0.9949	0.9722	FARSB/MTFMT/YARS2	3
KEGG	hsa03420	Nucleotide excision repair	2/532	47/8135	0.8223	0.9949	0.9722	POLD1/RPA4	2
KEGG	hsa04950	Maturity onset diabetes of the young	1/532	26/8135	0.8282	0.9949	0.9722	IAPP	1
KEGG	hsa04260	Cardiac muscle contraction	4/532	87/8135	0.8297	0.9949	0.9722	TPM3/MYL2/CACNG1/COX8A	4
KEGG	hsa04540	Gap junction	4/532	88/8135	0.8363	0.9949	0.9722	PRKCG/PRKACB/MAPK3/ITPR1	4
KEGG	hsa00062	Fatty acid elongation	1/532	27/8135	0.8394	0.9949	0.9722	ELOVL3	1
KEGG	hsa04976	Bile secretion	4/532	89/8135	0.8427	0.9949	0.9722	PRKACB/AQP8/UGT2B11/UGT1A6	4
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/532	89/8135	0.8427	0.9949	0.9722	PIK3CB/FOS/MAPK3/HIF1A	4
KEGG	hsa04622	RIG-I-like receptor signaling pathway	3/532	70/8135	0.8454	0.9949	0.9722	IFNA4/IKBKE/MAPK9	3
KEGG	hsa00510	N-Glycan biosynthesis	2/532	50/8135	0.8479	0.9949	0.9722	MAN1B1/ALG14	2
KEGG	hsa05410	Hypertrophic cardiomyopathy	4/532	90/8135	0.8489	0.9949	0.9722	TPM3/MYL2/CACNG1/PRKAG1	4
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	5/532	109/8135	0.8492	0.9949	0.9722	UTP14A/FBLL1/RCL1/XRN2/NXF3	5
KEGG	hsa04066	HIF-1 signaling pathway	5/532	109/8135	0.8492	0.9949	0.9722	PIK3CB/PRKCG/MAPK3/HIF1A/CDKN1A	5
KEGG	hsa03040	Spliceosome	7/532	147/8135	0.8547	0.9967	0.974	RBM22/PRPF8/SART1/PPIE/RBMX/ACIN1/PRPF4	7
KEGG	hsa04392	Hippo signaling pathway - multiple species	1/532	29/8135	0.8598	0.9967	0.974	CSNK1E	1
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	26/532	476/8135	0.8601	0.9967	0.974	GRIA4/ARAF/SDHB/GPX3/CAT/CSNK1E/TRPC3/PRKCG/HIP1/NDUFA9/FZD9/CSNK1A1/FIG4/KLC2/GPX1/AMBRA1/DCTN5/MAPK3/CACNA1B/MAPK9/CHRM1/CALM1/ITPR1/COX8A/MAP3K10/ATXN1	26
KEGG	hsa00030	Pentose phosphate pathway	1/532	30/8135	0.869	0.9986	0.9759	PRPS1L1	1
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/532	53/8135	0.8702	0.9986	0.9759	PRKCG/PRKACB	2
KEGG	hsa03320	PPAR signaling pathway	3/532	75/8135	0.8769	0.9986	0.9759	RXRB/PCK2/PLIN2	3
KEGG	hsa05164	Influenza A	8/532	171/8135	0.8793	0.9986	0.9759	PIK3CB/PLG/IFNA4/KPNA6/NLRP3/IKBKE/MAPK3/NXF3	8
KEGG	hsa05414	Dilated cardiomyopathy	4/532	96/8135	0.8818	0.9986	0.9759	TPM3/MYL2/PRKACB/CACNG1	4
KEGG	hsa04215	Apoptosis - multiple species	1/532	32/8135	0.8857	0.9986	0.9759	MAPK9	1
KEGG	hsa04932	Non-alcoholic fatty liver disease	7/532	155/8135	0.8887	0.9986	0.9759	SDHB/PIK3CB/NDUFA9/FOS/MAPK9/PRKAG1/COX8A	7
KEGG	hsa00051	Fructose and mannose metabolism	1/532	33/8135	0.8932	0.9986	0.9759	PFKFB2	1
KEGG	hsa04130	SNARE interactions in vesicular transport	1/532	33/8135	0.8932	0.9986	0.9759	SNAP23	1
KEGG	hsa01212	Fatty acid metabolism	2/532	57/8135	0.8952	0.9986	0.9759	ELOVL3/HSD17B4	2
KEGG	hsa04714	Thermogenesis	11/532	232/8135	0.9009	0.9986	0.9759	TSC2/SDHB/PRKACB/NDUFA9/CREB3L3/PRDM16/CREB3L4/COX15/PRKAG1/COX8A/BMP8B	11
KEGG	hsa05152	Tuberculosis	8/532	180/8135	0.9101	0.9986	0.9759	FCGR2B/ATP6V1H/IFNA4/MAPK3/MAPK9/CALM1/MALT1/CD209	8
KEGG	hsa04630	JAK-STAT signaling pathway	7/532	162/8135	0.9128	0.9986	0.9759	PIK3CB/GH1/IFNA4/IL24/CSF2RA/CSH1/CDKN1A	7
KEGG	hsa00561	Glycerolipid metabolism	2/532	61/8135	0.9157	0.9986	0.9759	ALDH1B1/LPIN1	2
KEGG	hsa01250	Biosynthesis of nucleotide sugars	1/532	37/8135	0.9186	0.9986	0.9759	CMAS	1
KEGG	hsa03250	Viral life cycle - HIV-1	2/532	63/8135	0.9245	0.9986	0.9759	PDCD6IP/ELL3	2
KEGG	hsa05034	Alcoholism	8/532	187/8135	0.9292	0.9986	0.9759	ARAF/HDAC10/PRKACB/CREB3L3/CREB3L4/MAPK3/CALM1/ATF6B	8
KEGG	hsa05321	Inflammatory bowel disease	2/532	65/8135	0.9324	0.9986	0.9759	SMAD2/MAF	2
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	5/532	131/8135	0.9365	0.9986	0.9759	ARAF/PIK3CB/PRKCG/IFNA4/MAPK3	5
KEGG	hsa04216	Ferroptosis	1/532	41/8135	0.938	0.9986	0.9759	GCLM	1
KEGG	hsa04145	Phagosome	6/532	152/8135	0.9387	0.9986	0.9759	ATP6V0E1/FCGR2B/ATP6V1H/ATP6V1E1/NCF4/CD209	6
KEGG	hsa04142	Lysosome	5/532	132/8135	0.939	0.9986	0.9759	AP3M1/ATP6V1H/CTSB/ACP5/AP1S2	5
KEGG	hsa05332	Graft-versus-host disease	1/532	42/8135	0.942	0.9986	0.9759	CD86	1
KEGG	hsa04975	Fat digestion and absorption	1/532	43/8135	0.9459	0.9986	0.9759	PLA2G2D	1
KEGG	hsa03022	Basal transcription factors	1/532	45/8135	0.9527	0.9986	0.9759	TAF1L	1
KEGG	hsa04740	Olfactory transduction	21/532	440/8135	0.9547	0.9986	0.9759	OR1K1/OR4C6/OR7D4/OR2T27/OR51D1/OR1F1/PRKACB/OR4N4/OR4C15/OR7C2/OR7G2/OR4D5/OR10H1/OR5A1/CALM1/OR10C1/OR52E2/ARRB1/OR8B3/OR13C2/OR2C1	21
KEGG	hsa05169	Epstein-Barr virus infection	8/532	202/8135	0.9586	0.9986	0.9759	PIK3CB/CD40/IFNA4/IKBKE/MAPK9/CCNE1/TAB1/CDKN1A	8
KEGG	hsa00514	Other types of O-glycan biosynthesis	1/532	47/8135	0.9587	0.9986	0.9759	GALNT12	1
KEGG	hsa04973	Carbohydrate digestion and absorption	1/532	47/8135	0.9587	0.9986	0.9759	PIK3CB	1
KEGG	hsa05415	Diabetic cardiomyopathy	8/532	203/8135	0.9601	0.9986	0.9759	SDHB/PIK3CB/SMAD2/PRKCG/NDUFA9/MAPK9/COX8A/NCF4	8
KEGG	hsa04640	Hematopoietic cell lineage	3/532	99/8135	0.9617	0.9986	0.9759	CD9/CD55/CSF2RA	3
KEGG	hsa04979	Cholesterol metabolism	1/532	50/8135	0.9664	0.9986	0.9759	LRP2	1
KEGG	hsa05144	Malaria	1/532	50/8135	0.9664	0.9986	0.9759	CD40	1
KEGG	hsa04613	Neutrophil extracellular trap formation	7/532	190/8135	0.9696	0.9986	0.9759	PIK3CB/HDAC10/PRKCG/CLCN4/CLCN3/MAPK3/NCF4	7
KEGG	hsa00600	Sphingolipid metabolism	1/532	52/8135	0.9706	0.9986	0.9759	B4GALNT1	1
KEGG	hsa05322	Systemic lupus erythematosus	4/532	136/8135	0.9809	0.9989	0.9761	C1S/C7/CD40/CD86	4
KEGG	hsa04978	Mineral absorption	1/532	60/8135	0.983	0.9989	0.9761	HEPHL1	1
KEGG	hsa05012	Parkinson disease	10/532	266/8135	0.9831	0.9989	0.9761	SDHB/SLC39A6/PRKACB/NDUFA9/DUSP1/KLC2/MAPK9/CALM1/ITPR1/COX8A	10
KEGG	hsa05010	Alzheimer disease	16/532	384/8135	0.9839	0.9989	0.9761	ARAF/SDHB/PIK3CB/CSNK1E/SLC39A6/NDUFA9/FZD9/CSNK1A1/KLC2/AMBRA1/MAPK3/MAPK9/CHRM1/CALM1/ITPR1/COX8A	16
KEGG	hsa05168	Herpes simplex virus 1 infection	20/532	495/8135	0.9947	0.9989	0.9761	TSC2/PIK3CB/ZNF514/ZNF713/ZNF667/ZNF250/ZNF169/ZNF527/IFNA4/ZNF235/IKBKE/ZNF426/EIF2B5/ZNF490/NXF3/ZNF582/TAB1/ZNF577/ZNF705A/ZNF597	20
KEGG	hsa04612	Antigen processing and presentation	1/532	78/8135	0.995	0.9989	0.9761	CTSB	1
KEGG	hsa05014	Amyotrophic lateral sclerosis	12/532	364/8135	0.9982	0.9989	0.9761	SDHB/GPX3/CAT/GLE1/NDUFA9/FIG4/KLC2/GPX1/AMBRA1/DCTN5/NXF3/COX8A	12
KEGG	hsa03010	Ribosome	3/532	158/8135	0.9985	0.9989	0.9761	MRPS15/RPL36A-HNRNPH2/RPS26	3
KEGG	hsa05206	MicroRNAs in cancer	9/532	310/8135	0.9989	0.9989	0.9761	PIK3CB/TNR/KIF23/PRKCG/CRK/MAPK3/UBE2I/CCNE1/CDKN1A	9