ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	52/464	476/8135	3.384e-06	0.0009245	0.0007486	RAB5A/GNAQ/VDAC1/RAB1A/DCTN4/COX5A/SDHC/ATF4/UQCRC2/TUBB2A/MFN2/PIK3C3/BCL2/DNAH11/MAPK13/TUBB6/PPIF/CASP9/UBE2J2/CAT/PRNP/VDAC3/SLC25A6/FZD6/HTT/ATXN1L/FAS/UBE2J1/PSMD13/MAP2K2/VDAC2/UQCRC1/PSMC3/CDK5/NRAS/ITPR1/PSMD9/IL6/VAPB/UBE2G1/PPP3R2/MAPK14/MFN1/GRIA2/TUBA8/HSPA5/NDUFA5/FASLG/AGER/DCTN6/CASP8/PIK3R4	52
KEGG	hsa05130	Pathogenic Escherichia coli infection	28/464	197/8135	6.188e-06	0.0009245	0.0007486	RHOA/SEC24A/RAB1A/ARPC5/WASF1/ACTR2/TUBB2A/MAPK13/TUBB6/TMED10/CASP9/FAS/ARF6/CTTN/NCK2/IL6/ARPC4/SEC24C/MAPK14/GAPDH/TUBA8/CYTH4/IRAK1/CLDN15/FASLG/WASF2/CASP8/ACTR3B	28
KEGG	hsa05132	Salmonella infection	32/464	249/8135	1.176e-05	0.0009245	0.0007486	RAB5A/RHOA/RAB7A/ARPC5/DCTN4/DYNLRB1/ACTR2/TUBB2A/MLKL/PIK3C3/BCL2/MAPK13/TUBB6/PTPRC/PIK3CA/MAP2K2/ARF6/DYNLL2/IL6/ARPC4/MAPK14/RAB5C/RIPK3/TLR6/GAPDH/TUBA8/CYTH4/IRAK1/DCTN6/DYNLT1/CASP8/ACTR3B	32
KEGG	hsa04141	Protein processing in endoplasmic reticulum	25/464	171/8135	1.185e-05	0.0009245	0.0007486	SEC24A/TRAM1/RAD23B/ATF4/BCL2/EDEM1/SEC61A1/HSPA6/SEC23A/BAG1/UBE2J2/MAN1A1/MBTPS1/UBE2J1/UBE2D1/ERLEC1/P4HB/UBE2G1/SEC24C/SSR1/UGGT1/UBE4B/HSPA5/SEC13/SAR1A	25
KEGG	hsa05135	Yersinia infection	21/464	137/8135	2.88e-05	0.001797	0.001455	RHOA/GNAQ/SKAP2/ARPC5/ACTR2/VAV1/MAPK13/IL10/PIK3CA/MAP2K2/ARF6/ITGA4/IL6/ARPC4/MAPK14/IRAK1/TICAM1/PIP5K1A/WASF2/RAC3/ACTR3B	21
KEGG	hsa05161	Hepatitis B	22/464	162/8135	0.0001223	0.006361	0.005151	SOS1/ATF4/BCL2/TRAF3/MAPK13/RB1/CASP9/VDAC3/FAS/PIK3CA/MAP2K2/NRAS/JAK1/IL6/MAPK14/YWHAZ/CDK2/IRAK1/DDB2/TICAM1/FASLG/CASP8	22
KEGG	hsa05160	Hepatitis C	21/464	157/8135	0.0002155	0.009604	0.007777	SOCS3/SOS1/PIAS1/TRAF3/RB1/CASP9/FAS/YWHAE/PIK3CA/MAP2K2/NRAS/PPP2R2B/LDLR/JAK1/CDK6/YWHAZ/CDK2/TICAM1/CLDN15/FASLG/CASP8	21
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	15/464	97/8135	0.0003579	0.01352	0.01095	ARPC5/WASF1/ACTR2/VAV1/ASAP1/PTPRC/AMPH/PIK3CA/ARF6/ARPC4/FCGR1A/PLCG2/PIP5K1A/WASF2/ACTR3B	15
KEGG	hsa04722	Neurotrophin signaling pathway	17/464	119/8135	0.00039	0.01352	0.01095	RHOA/SOS1/ATF4/ARHGDIB/BCL2/MAPK13/SH2B1/YWHAE/PIK3CA/MAP2K2/SORT1/NRAS/MAPK14/ARHGDIA/IRAK1/PLCG2/FASLG	17
KEGG	hsa05010	Alzheimer disease	38/464	384/8135	0.0005713	0.01782	0.01443	GNAQ/VDAC1/APH1A/COX5A/SDHC/ATF4/UQCRC2/TUBB2A/INSR/PIK3C3/TUBB6/PPIF/CASP9/VDAC3/SLC25A6/FZD6/FAS/PSMD13/PIK3CA/MAP2K2/VDAC2/UQCRC1/PSMC3/CDK5/SLC39A6/IDE/NRAS/ITPR1/PSMD9/IL6/PPP3R2/ADAM10/GAPDH/TUBA8/NDUFA5/AGER/CASP8/PIK3R4	38
KEGG	hsa05020	Prion disease	29/464	273/8135	0.0008456	0.02399	0.01942	VDAC1/COX5A/SDHC/ATF4/UQCRC2/TUBB2A/MAPK13/TUBB6/HSPA6/PPIF/CASP9/PRNP/VDAC3/SLC25A6/PSMD13/PIK3CA/VDAC2/UQCRC1/PSMC3/ITPR1/PSMD9/C8A/IL6/PPP3R2/MAPK14/TUBA8/C6/HSPA5/NDUFA5	29
KEGG	hsa03060	Protein export	6/464	23/8135	0.001463	0.03805	0.03081	SRP72/SEC61A1/OXA1L/SRPRB/SPCS2/HSPA5	6
KEGG	hsa04216	Ferroptosis	8/464	41/8135	0.0019	0.0456	0.03692	SLC3A2/ACSL3/PRNP/VDAC3/ATG5/VDAC2/ATG7/SAT2	8
KEGG	hsa01200	Carbon metabolism	15/464	115/8135	0.00216	0.04813	0.03897	ENO1/SDHC/ADPGK/SUCLG2/CAT/GPT2/PFKP/GLUD2/PSAT1/GLUD1/GAPDH/ACAT1/PRPS1/PGK1/ME2	15
KEGG	hsa05012	Parkinson disease	27/464	266/8135	0.002457	0.05052	0.04091	VDAC1/COX5A/SDHC/ATF4/UQCRC2/TUBB2A/DUSP1/MFN2/TUBB6/PPIF/CASP9/UBE2J2/VDAC3/SLC25A6/UBE2J1/PSMD13/VDAC2/UQCRC1/PSMC3/SLC39A6/ITPR1/PSMD9/UBE2G1/MFN1/TUBA8/HSPA5/NDUFA5	27
KEGG	hsa05417	Lipid and atherosclerosis	23/464	215/8135	0.002591	0.05052	0.04091	RHOA/ATF4/VAV1/BCL2/TRAF3/MAPK13/HSPA6/CASP9/FAS/PIK3CA/NRAS/ITPR1/LDLR/IL6/PPP3R2/MAPK14/TLR6/IRAK1/HSPA5/TICAM1/FASLG/AGER/CASP8	23
KEGG	hsa04068	FoxO signaling pathway	16/464	131/8135	0.003083	0.05658	0.04582	CDKN2D/SOS1/INSR/PRKAG2/HOMER3/CCNG2/MAPK13/CAT/IL10/PIK3CA/MAP2K2/NRAS/IL6/MAPK14/CDK2/FASLG	16
KEGG	hsa04621	NOD-like receptor signaling pathway	20/464	184/8135	0.004014	0.06637	0.05374	RHOA/VDAC1/MFN2/BCL2/TRAF3/MAPK13/VDAC3/ATG5/YWHAE/VDAC2/DNM1L/ITPR1/JAK1/IL6/MAPK14/MFN1/RIPK3/TICAM1/CASP8/TP53BP1	20
KEGG	hsa05100	Bacterial invasion of epithelial cells	11/464	77/8135	0.004042	0.06637	0.05374	RHOA/ARPC5/WASF1/ACTR2/CTNNA1/PIK3CA/CTTN/ARPC4/MAD2L2/WASF2/ACTR3B	11
KEGG	hsa04664	Fc epsilon RI signaling pathway	10/464	68/8135	0.004871	0.07493	0.06067	SOS1/VAV1/MAPK13/PIK3CA/MAP2K2/NRAS/MAPK14/PLCG2/RAC3/IL5	10
KEGG	hsa05142	Chagas disease	13/464	102/8135	0.00509	0.07493	0.06067	GNAQ/MAPK13/IL10/FAS/PIK3CA/PPP2R2B/IL6/MAPK14/TLR6/IRAK1/TICAM1/FASLG/CASP8	13
KEGG	hsa05418	Fluid shear stress and atherosclerosis	16/464	139/8135	0.005548	0.07493	0.06067	RHOA/SDC4/PECAM1/ITGA2B/DUSP1/BCL2/MAPK13/IL1R2/GSTA1/PIK3CA/BMP4/SUMO1/MAPK14/ACVR2A/GSTT2/RAC3	16
KEGG	hsa05415	Diabetic cardiomyopathy	21/464	203/8135	0.005768	0.07493	0.06067	VDAC1/COX5A/SDHC/UQCRC2/INSR/MAPK13/PPIF/PPP1CB/VDAC3/SLC25A6/PIK3CA/SP1/VDAC2/GSR/UQCRC1/GFPT1/MAPK14/SLC2A1/GAPDH/NDUFA5/AGER	21
KEGG	hsa04370	VEGF signaling pathway	9/464	59/8135	0.005809	0.07493	0.06067	MAPK13/CASP9/PIK3CA/MAP2K2/NRAS/PPP3R2/MAPK14/PLCG2/RAC3	9
KEGG	hsa04660	T cell receptor signaling pathway	13/464	104/8135	0.006004	0.07493	0.06067	RHOA/SOS1/VAV1/MAPK13/IL10/PTPRC/PIK3CA/MAP2K2/NCK2/NRAS/PPP3R2/MAPK14/IL5	13
KEGG	hsa05152	Tuberculosis	19/464	180/8135	0.006815	0.08051	0.06519	RAB5A/RHOA/RAB7A/HSPA9/PIK3C3/BCL2/MAPK13/CASP9/IL10/NFYC/JAK1/IL6/PPP3R2/MAPK14/RAB5C/FCGR1A/TLR6/IRAK1/CASP8	19
KEGG	hsa04932	Non-alcoholic fatty liver disease	17/464	155/8135	0.007026	0.08051	0.06519	SOCS3/MLX/COX5A/SDHC/ATF4/UQCRC2/INSR/PRKAG2/MAPK13/FAS/PIK3CA/UQCRC1/IL6/MAPK14/NDUFA5/FASLG/CASP8	17
KEGG	hsa05017	Spinocerebellar ataxia	16/464	143/8135	0.007278	0.08051	0.06519	GNAQ/VDAC1/PIK3C3/PPIF/VDAC3/SLC25A6/ATXN1L/PSMD13/PIK3CA/SP1/VDAC2/PSMC3/ITPR1/PSMD9/GRIA2/PIK3R4	16
KEGG	hsa04218	Cellular senescence	17/464	156/8135	0.007484	0.08051	0.06519	VDAC1/MAPK13/RB1/PPP1CB/VDAC3/SLC25A6/PIK3CA/MAP2K2/VDAC2/NRAS/ITPR1/ETS1/IL6/CDK6/PPP3R2/MAPK14/CDK2	17
KEGG	hsa05016	Huntington disease	28/464	306/8135	0.008701	0.08515	0.06894	GNAQ/VDAC1/DCTN4/COX5A/SDHC/UQCRC2/TUBB2A/PIK3C3/DNAH11/TUBB6/PPIF/CASP9/VDAC3/SLC25A6/HTT/PSMD13/SP1/VDAC2/UQCRC1/PSMC3/ITPR1/PSMD9/GRIA2/TUBA8/NDUFA5/DCTN6/CASP8/PIK3R4	28
KEGG	hsa04066	HIF-1 signaling pathway	13/464	109/8135	0.00887	0.08515	0.06894	ENO1/LDHC/INSR/BCL2/PIK3CA/MAP2K2/PFKP/IL6/SLC2A1/LDHA/GAPDH/PLCG2/PGK1	13
KEGG	hsa05163	Human cytomegalovirus infection	22/464	225/8135	0.009175	0.08515	0.06894	RHOA/GNAQ/SOS1/ATF4/MAPK13/RB1/CASP9/FAS/PIK3CA/MAP2K2/SP1/TAPBP/NRAS/ITPR1/JAK1/IL6/CDK6/PPP3R2/MAPK14/FASLG/CASP8/RAC3	22
KEGG	hsa05014	Amyotrophic lateral sclerosis	32/464	364/8135	0.009307	0.08515	0.06894	RAB5A/VDAC1/RAB1A/DCTN4/COX5A/SDHC/ATF4/UQCRC2/TUBB2A/PIK3C3/BCL2/DNAH11/MAPK13/TUBB6/CASP9/CAT/GLE1/PSMD13/UQCRC1/PSMC3/PSMD9/VAPB/NXT2/PPP3R2/MAPK14/GRIA2/TUBA8/HSPA5/NDUFA5/SEC13/DCTN6/PIK3R4	32
KEGG	hsa05210	Colorectal cancer	11/464	86/8135	0.00935	0.08515	0.06894	RHOA/SOS1/MSH3/BCL2/CASP9/PIK3CA/MAP2K2/NRAS/RALB/DDB2/RAC3	11
KEGG	hsa05231	Choline metabolism in cancer	12/464	98/8135	0.009552	0.08515	0.06894	SOS1/WASF1/CHKA/CHPT1/PIK3CA/MAP2K2/SP1/DGKA/NRAS/PIP5K1A/WASF2/RAC3	12
KEGG	hsa04668	TNF signaling pathway	13/464	112/8135	0.01105	0.09314	0.07542	SOCS3/ATF4/MLKL/TRAF3/MAPK13/FAS/PIK3CA/DNM1L/IL6/MAPK14/RIPK3/CCL20/CASP8	13
KEGG	hsa05145	Toxoplasmosis	13/464	112/8135	0.01105	0.09314	0.07542	ITGA6/BCL2/MAPK13/HSPA6/PPIF/CASP9/IL10/PIK3R5/LDLR/JAK1/MAPK14/IRAK1/CASP8	13
KEGG	hsa04962	Vasopressin-regulated water reabsorption	7/464	44/8135	0.01147	0.09414	0.07622	RAB5A/DCTN4/ARHGDIB/DYNLL2/RAB5C/ARHGDIA/DCTN6	7
KEGG	hsa00010	Glycolysis / Gluconeogenesis	9/464	67/8135	0.01324	0.1059	0.08575	ENO1/LDHC/ADPGK/GAPDHS/MINPP1/PFKP/LDHA/GAPDH/PGK1	9
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/464	194/8135	0.01461	0.1139	0.09225	PIK3C3/TRAF3/MAPK13/RB1/CASP9/FAS/PIK3CA/MAP2K2/PIK3R5/NRAS/ITPR1/JAK1/IL6/CDK6/PPP3R2/MAPK14/TICAM1/PLCG2/CASP8	19
KEGG	hsa04120	Ubiquitin mediated proteolysis	15/464	142/8135	0.01515	0.1153	0.09335	SOCS3/SAE1/PIAS1/ANAPC2/UBE2J2/UBE2M/MGRN1/UBE2J1/UBE2D1/UBA2/DET1/UBE2G1/UBE2H/UBE4B/DDB2	15
KEGG	hsa04144	Endocytosis	23/464	251/8135	0.01626	0.1208	0.0978	ARF4/RAB5A/RHOA/RAB7A/ARPC5/ACTR2/ARAP3/ARAP1/HSPA6/ASAP1/CHMP4B/AMPH/DAB2/ARFGEF1/ARF6/LDLR/ARPC4/RAB5C/CYTH4/SNX4/PIP5K1A/ARFGAP3/ACTR3B	23
KEGG	hsa05230	Central carbon metabolism in cancer	9/464	70/8135	0.01734	0.1258	0.1019	FLT3/LDHC/PIK3CA/MAP2K2/SLC7A5/NRAS/PFKP/SLC2A1/LDHA	9
KEGG	hsa04217	Necroptosis	16/464	159/8135	0.01893	0.1343	0.1087	VDAC1/MLKL/BCL2/CHMP4B/VDAC3/SLC25A6/FAS/VDAC2/DNM1L/JAK1/GLUD2/GLUD1/RIPK3/TICAM1/FASLG/CASP8	16
KEGG	hsa05223	Non-small cell lung cancer	9/464	72/8135	0.02054	0.1424	0.1153	SOS1/RB1/CASP9/PIK3CA/MAP2K2/NRAS/CDK6/DDB2/PLCG2	9
KEGG	hsa05169	Epstein-Barr virus infection	19/464	202/8135	0.0215	0.1449	0.1173	BCL2/TRAF3/MAPK13/RB1/CASP9/FAS/PSMD13/PIK3CA/PSMC3/TAPBP/JAK1/IL6/CDK6/MAPK14/CDK2/IRAK1/DDB2/PLCG2/CASP8	19
KEGG	hsa01524	Platinum drug resistance	9/464	73/8135	0.02229	0.1449	0.1173	MSH3/BCL2/CASP9/GSTA1/FAS/PIK3CA/GSTT2/FASLG/CASP8	9
KEGG	hsa04115	p53 signaling pathway	9/464	73/8135	0.02229	0.1449	0.1173	BCL2/CCNG2/CASP9/FAS/CDK6/CDK2/CCNG1/DDB2/CASP8	9
KEGG	hsa04810	Regulation of actin cytoskeleton	20/464	218/8135	0.02373	0.1511	0.1223	RHOA/SOS1/ITGA6/ARPC5/WASF1/ITGA2B/ACTR2/VAV1/PPP1CB/PIK3CA/MAP2K2/ITGA4/FGF3/NRAS/ARPC4/PIP5K1A/WASF2/FGF5/RAC3/ACTR3B	20
KEGG	hsa04640	Hematopoietic cell lineage	11/464	99/8135	0.02493	0.1556	0.126	FLT3/ITGA6/ITGA2B/IL11RA/IL1R2/ITGA4/CD7/IL6/EPOR/FCGR1A/IL5	11
KEGG	hsa04915	Estrogen signaling pathway	14/464	138/8135	0.02544	0.1556	0.126	GNAQ/SOS1/ATF4/GPER1/BCL2/HSPA6/PIK3CA/MAP2K2/SP1/KRT37/NRAS/ITPR1/KRT32/FKBP5	14
KEGG	hsa01230	Biosynthesis of amino acids	9/464	75/8135	0.02611	0.1567	0.1269	ENO1/BCAT1/MAT2A/GPT2/PFKP/PSAT1/GAPDH/PRPS1/PGK1	9
KEGG	hsa05162	Measles	14/464	139/8135	0.02687	0.1582	0.1281	BCL2/TRAF3/HSPA6/CASP9/FAS/PIK3CA/CD46/JAK1/IL6/CDK6/CDK2/IRAK1/FASLG/CASP8	14
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	20/464	223/8135	0.02936	0.1696	0.1374	VDAC1/SOS1/COX5A/SDHC/UQCRC2/MAPK13/PPIF/CAT/VDAC3/GSTA1/SLC25A6/EPHX3/PIK3CA/MAP2K2/VDAC2/UQCRC1/NRAS/MAPK14/GSTT2/NDUFA5	20
KEGG	hsa04150	mTOR signaling pathway	15/464	156/8135	0.03238	0.1837	0.1487	RHOA/ATP6V1A/SOS1/SLC3A2/GRB10/INSR/STRADB/FZD6/PIK3CA/MAP2K2/ATP6V1C1/SLC7A5/NRAS/DDIT4/SEC13	15
KEGG	hsa04625	C-type lectin receptor signaling pathway	11/464	104/8135	0.03429	0.1877	0.152	RHOA/MAPK13/IL10/PIK3CA/NRAS/ITPR1/IL6/PPP3R2/MAPK14/PLCG2/CASP8	11
KEGG	hsa05164	Influenza A	16/464	171/8135	0.03451	0.1877	0.152	SOCS3/VDAC1/TRAF3/CASP9/SLC25A6/FAS/PIK3CA/MAP2K2/JAK1/IL6/CDK6/NXT2/TICAM1/FASLG/TMPRSS4/CASP8	16
KEGG	hsa03018	RNA degradation	9/464	79/8135	0.0351	0.1877	0.152	XRN2/CNOT2/ENO1/HSPA9/TTC37/CNOT6L/CNOT7/PFKP/EXOSC2	9
KEGG	hsa04720	Long-term potentiation	8/464	67/8135	0.03582	0.1877	0.152	GNAQ/ATF4/PPP1CB/MAP2K2/NRAS/ITPR1/PPP3R2/GRIA2	8
KEGG	hsa05222	Small cell lung cancer	10/464	92/8135	0.03611	0.1877	0.152	ITGA6/ITGA2B/BCL2/TRAF3/RB1/CASP9/PIK3CA/CDK6/CDK2/DDB2	10
KEGG	hsa04071	Sphingolipid signaling pathway	12/464	119/8135	0.03833	0.1929	0.1562	SPTLC1/RHOA/GNAQ/CERS6/BCL2/MAPK13/PIK3CA/MAP2K2/NRAS/PPP2R2B/MAPK14/RAC3	12
KEGG	hsa04935	Growth hormone synthesis, secretion and action	12/464	119/8135	0.03833	0.1929	0.1562	SOCS3/GNAQ/SOS1/ATF4/MAPK13/PIK3CA/MAP2K2/NRAS/ITPR1/MAPK14/PLCG2/SSTR2	12
KEGG	hsa05134	Legionellosis	7/464	57/8135	0.04214	0.2037	0.165	RAB1A/HSPA6/CASP9/IL6/CLK4/SAR1A/CASP8	7
KEGG	hsa04072	Phospholipase D signaling pathway	14/464	148/8135	0.04258	0.2037	0.165	RHOA/SOS1/INSR/AGPAT2/PIK3CA/MAP2K2/PIK3R5/ARF6/DGKA/NRAS/RALB/CYTH4/PLCG2/PIP5K1A	14
KEGG	hsa05131	Shigellosis	21/464	247/8135	0.04287	0.2037	0.165	RHOA/VDAC1/ARPC5/WASF1/ACTR2/PIK3C3/BCL2/MAPK13/ATG5/PIK3CA/UBE2D1/ARF6/CTTN/ITPR1/ARPC4/MAPK14/CYTH4/PLCG2/WASF2/PIK3R4/ACTR3B	21
KEGG	hsa04662	B cell receptor signaling pathway	9/464	82/8135	0.0431	0.2037	0.165	SOS1/VAV1/PIK3CA/MAP2K2/NRAS/PPP3R2/DAPP1/PLCG2/RAC3	9
KEGG	hsa04917	Prolactin signaling pathway	8/464	70/8135	0.04479	0.2086	0.1689	SOCS3/SOS1/MAPK13/PIK3CA/MAP2K2/NRAS/MAPK14/GALT	8
KEGG	hsa05213	Endometrial cancer	7/464	58/8135	0.04567	0.2087	0.169	SOS1/CTNNA1/CASP9/PIK3CA/MAP2K2/NRAS/DDB2	7
KEGG	hsa04210	Apoptosis	13/464	136/8135	0.04616	0.2087	0.169	ATF4/BCL2/CASP9/FAS/ENDOG/PIK3CA/MAP2K2/SPTA1/NRAS/ITPR1/TUBA8/FASLG/CASP8	13
KEGG	hsa04151	PI3K-Akt signaling pathway	28/464	354/8135	0.04829	0.2128	0.1723	FLT3/SOS1/ITGA6/ITGA2B/CDC37/ATF4/INSR/BCL2/OSM/CASP9/YWHAE/PIK3CA/MAP2K2/PIK3R5/ITGA4/FGF3/NRAS/PPP2R2B/JAK1/IL6/CDK6/COL9A2/YWHAZ/EPOR/DDIT4/CDK2/FASLG/FGF5	28
KEGG	hsa04070	Phosphatidylinositol signaling system	10/464	97/8135	0.0491	0.2128	0.1723	IMPAD1/PIK3C3/PIK3CA/PI4KA/DGKA/ITPR1/INPP5A/MTMR2/PLCG2/PIP5K1A	10
KEGG	hsa05215	Prostate cancer	10/464	97/8135	0.0491	0.2128	0.1723	SOS1/ATF4/BCL2/RB1/IL1R2/CASP9/PIK3CA/MAP2K2/NRAS/CDK2	10
KEGG	hsa04145	Phagosome	14/464	152/8135	0.05132	0.2136	0.1729	RAB5A/ATP6V1A/RAB7A/VAMP3/TUBB2A/PIK3C3/TUBB6/SEC61A1/ATP6V1C1/MARCO/RAB5C/FCGR1A/TLR6/TUBA8	14
KEGG	hsa04137	Mitophagy - animal	8/464	72/8135	0.05152	0.2136	0.1729	RAB7A/ATF4/MFN2/ATG5/SP1/NRAS/TBC1D15/MFN1	8
KEGG	hsa05218	Melanoma	8/464	72/8135	0.05152	0.2136	0.1729	RB1/PIK3CA/MAP2K2/FGF3/NRAS/CDK6/DDB2/FGF5	8
KEGG	hsa01522	Endocrine resistance	10/464	98/8135	0.05203	0.2136	0.1729	SOS1/GPER1/BCL2/MAPK13/RB1/PIK3CA/MAP2K2/SP1/NRAS/MAPK14	10
KEGG	hsa04022	cGMP-PKG signaling pathway	15/464	167/8135	0.05367	0.2174	0.1761	RHOA/GNAQ/VDAC1/ATF4/INSR/PPIF/PPP1CB/VDAC3/SLC25A6/ADRB2/MAP2K2/VDAC2/PIK3R5/ITPR1/PPP3R2	15
KEGG	hsa00562	Inositol phosphate metabolism	8/464	73/8135	0.05511	0.2205	0.1785	PIK3C3/PIK3CA/PI4KA/MINPP1/INPP5A/MTMR2/PLCG2/PIP5K1A	8
KEGG	hsa05143	African trypanosomiasis	5/464	37/8135	0.05716	0.2258	0.1828	GNAQ/IL10/FAS/IL6/FASLG	5
KEGG	hsa05170	Human immunodeficiency virus 1 infection	18/464	212/8135	0.0584	0.2278	0.1844	GNAQ/BCL2/MAPK13/CASP9/FAS/PIK3CA/MAP2K2/TAPBP/NRAS/ITPR1/PPP3R2/MAPK14/IRAK1/AP1S2/PLCG2/FASLG/CASP8/RAC3	18
KEGG	hsa04670	Leukocyte transendothelial migration	11/464	114/8135	0.05993	0.23	0.1862	RHOA/PECAM1/VAV1/CTNNA1/MAPK13/CD99/PIK3CA/ITGA4/MAPK14/CLDN15/PLCG2	11
KEGG	hsa04213	Longevity regulating pathway - multiple species	7/464	62/8135	0.06168	0.23	0.1862	INSR/PRKAG2/HSPA6/CAT/ATG5/PIK3CA/NRAS	7
KEGG	hsa05214	Glioma	8/464	75/8135	0.06278	0.23	0.1862	SOS1/RB1/PIK3CA/MAP2K2/NRAS/CDK6/DDB2/PLCG2	8
KEGG	hsa00510	N-Glycan biosynthesis	6/464	50/8135	0.0634	0.23	0.1862	ALG5/MAN1A1/MGAT3/MGAT4A/MGAT2/DPM1	6
KEGG	hsa04979	Cholesterol metabolism	6/464	50/8135	0.0634	0.23	0.1862	VDAC1/VDAC3/VDAC2/SORT1/LDLR/VAPB	6
KEGG	hsa05110	Vibrio cholerae infection	6/464	50/8135	0.0634	0.23	0.1862	ATP6V1A/SLC12A2/KDELR2/SEC61A1/ATP6V1C1/PLCG2	6
KEGG	hsa05212	Pancreatic cancer	8/464	76/8135	0.06685	0.2397	0.1941	RB1/CASP9/PIK3CA/JAK1/CDK6/RALB/DDB2/RAC3	8
KEGG	hsa04929	GnRH secretion	7/464	64/8135	0.07082	0.2511	0.2033	GNAQ/GPER1/PIK3CA/MAP2K2/KISS1R/NRAS/ITPR1	7
KEGG	hsa04620	Toll-like receptor signaling pathway	10/464	104/8135	0.07205	0.2526	0.2045	TRAF3/MAPK13/PIK3CA/MAP2K2/IL6/MAPK14/TLR6/IRAK1/TICAM1/CASP8	10
KEGG	hsa04613	Neutrophil extracellular trap formation	16/464	190/8135	0.07564	0.2622	0.2123	VDAC1/ITGA2B/MAPK13/PPIF/VDAC3/SLC25A6/PIK3CA/MAP2K2/VDAC2/MAPK14/ATG7/HDAC7/FPR2/FCGR1A/PLCG2/AGER	16
KEGG	hsa04630	JAK-STAT signaling pathway	14/464	162/8135	0.07837	0.2684	0.2174	SOCS3/SOS1/PIAS1/IL11RA/BCL2/OSM/IL10/PIK3CA/IL13RA1/JAK1/IL6/EPOR/CTF1/IL5	14
KEGG	hsa00061	Fatty acid biosynthesis	3/464	18/8135	0.07953	0.2684	0.2174	ACSL3/OLAH/ACSBG1	3
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/464	79/8135	0.08001	0.2684	0.2174	SOS1/BCL2/PIK3CA/MAP2K2/NRAS/JAK1/IL6/PLCG2	8
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	18/464	222/8135	0.08277	0.2747	0.2225	PTTG2/VDAC1/ATF4/ANAPC2/RB1/IL1R2/VDAC3/SLC25A6/PIK3CA/MAP2K2/VDAC2/NRAS/JAK1/ETS1/IL6/PPP3R2/SLC2A1/CDK2	18
KEGG	hsa05221	Acute myeloid leukemia	7/464	67/8135	0.08597	0.2823	0.2286	FLT3/SOS1/PIK3CA/MAP2K2/NRAS/ZBTB16/FCGR1A	7
KEGG	hsa04657	IL-17 signaling pathway	9/464	94/8135	0.08687	0.2823	0.2286	TRAF3/MAPK13/ELAVL1/IL17RA/IL6/MAPK14/CCL20/CASP8/IL5	9
KEGG	hsa04931	Insulin resistance	10/464	108/8135	0.08777	0.2823	0.2286	SOCS3/MLX/INSR/PRKAG2/PPP1R3B/PPP1CB/PIK3CA/IL6/GFPT1/SLC2A1	10
KEGG	hsa03015	mRNA surveillance pathway	9/464	97/8135	0.1009	0.3212	0.26	ETF1/UPF1/MSI2/PPP1CB/GLE1/RNMT/PPP2R2B/NXT2/NUDT21	9
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	9/464	98/8135	0.1058	0.3264	0.2643	PRKCH/GNAQ/MAPK13/PPP1CB/IL1RAP/PIK3CA/ITPR1/MAPK14/PLCG2	9
KEGG	hsa00640	Propanoate metabolism	4/464	32/8135	0.1067	0.3264	0.2643	LDHC/SUCLG2/LDHA/ECHDC1	4
KEGG	hsa04136	Autophagy - other	4/464	32/8135	0.1067	0.3264	0.2643	PIK3C3/ATG5/ATG7/PIK3R4	4
KEGG	hsa04140	Autophagy - animal	12/464	141/8135	0.1067	0.3264	0.2643	RAB7A/RAB1A/PIK3C3/BCL2/ATG5/PIK3CA/MAP2K2/NRAS/ITPR1/ATG7/DDIT4/PIK3R4	12
KEGG	hsa00920	Sulfur metabolism	2/464	10/8135	0.1079	0.3267	0.2646	IMPAD1/PAPSS1	2
KEGG	hsa04014	Ras signaling pathway	18/464	232/8135	0.113	0.3391	0.2746	RAB5A/FLT3/RHOA/SOS1/INSR/PIK3CA/MAP2K2/ARF6/FGF3/NRAS/ETS1/RGL2/RAB5C/RALB/PLCG2/FASLG/FGF5/RAC3	18
KEGG	hsa04010	MAPK signaling pathway	22/464	294/8135	0.1152	0.3417	0.2767	FLT3/SOS1/DUSP3/ATF4/DUSP1/INSR/MAPK13/HSPA6/MAPK8IP2/IL1RAP/FAS/MAP2K2/FGF3/NRAS/TAOK2/PPP3R2/MAPK14/CACNA2D3/IRAK1/FASLG/FGF5/RAC3	22
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/464	100/8135	0.1161	0.3417	0.2767	BCL2/MAPK13/PIK3CA/NRAS/F3/IL6/MAPK14/PLCG2/AGER	9
KEGG	hsa05205	Proteoglycans in cancer	16/464	205/8135	0.1248	0.3567	0.2888	RHOA/SDC4/SOS1/VAV1/MAPK13/PPP1CB/FZD6/FAS/PIK3CA/MAP2K2/CTTN/NRAS/ITPR1/MAPK14/PLCG2/FASLG	16
KEGG	hsa05146	Amoebiasis	9/464	102/8135	0.1269	0.3567	0.2888	RAB5A/GNAQ/RAB7A/IL1R2/IL10/PIK3CA/C8A/IL6/RAB5C	9
KEGG	hsa04114	Oocyte meiosis	11/464	131/8135	0.1272	0.3567	0.2888	PTTG2/ANAPC2/MAPK13/PPP1CB/YWHAE/ITPR1/PPP3R2/MAPK14/YWHAZ/CDK2/MAD2L2	11
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	11/464	131/8135	0.1272	0.3567	0.2888	SOS1/VAV1/HCST/FAS/PIK3CA/MAP2K2/NRAS/PPP3R2/PLCG2/FASLG/RAC3	11
KEGG	hsa00220	Arginine biosynthesis	3/464	22/8135	0.1273	0.3567	0.2888	GPT2/GLUD2/GLUD1	3
KEGG	hsa04540	Gap junction	8/464	88/8135	0.128	0.3567	0.2888	GNAQ/SOS1/TUBB2A/TUBB6/MAP2K2/NRAS/ITPR1/TUBA8	8
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/464	89/8135	0.1341	0.3682	0.2982	MAPK13/PIK3CA/MAP2K2/NRAS/JAK1/PPP3R2/MAPK14/TICAM1	8
KEGG	hsa04918	Thyroid hormone synthesis	7/464	75/8135	0.1346	0.3682	0.2982	GNAQ/SLC26A4/ATF4/DUOX1/GSR/ITPR1/HSPA5	7
KEGG	hsa05410	Hypertrophic cardiomyopathy	8/464	90/8135	0.1404	0.3771	0.3054	ITGA6/ITGA2B/PRKAG2/EMD/ITGA4/IL6/CACNA2D3/TPM4	8
KEGG	hsa05133	Pertussis	7/464	76/8135	0.1414	0.3771	0.3054	RHOA/MAPK13/IL10/IL6/MAPK14/IRAK1/TICAM1	7
KEGG	hsa05220	Chronic myeloid leukemia	7/464	76/8135	0.1414	0.3771	0.3054	SOS1/RB1/PIK3CA/MAP2K2/NRAS/CDK6/DDB2	7
KEGG	hsa05226	Gastric cancer	12/464	149/8135	0.1429	0.3778	0.3059	SOS1/BCL2/CTNNA1/RB1/FZD6/PIK3CA/MAP2K2/FGF3/NRAS/CDK2/DDB2/FGF5	12
KEGG	hsa04015	Rap1 signaling pathway	16/464	210/8135	0.1446	0.3792	0.3071	EVL/RHOA/GNAQ/ITGA2B/ARAP3/INSR/VAV1/MAPK13/PIK3CA/MAP2K2/FGF3/NRAS/MAPK14/RALB/FGF5/RAC3	16
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	4/464	36/8135	0.1469	0.3797	0.3074	NMNAT3/NADK2/NNT/NADK	4
KEGG	hsa05140	Leishmaniasis	7/464	77/8135	0.1485	0.3797	0.3074	MAPK13/IL10/ITGA4/JAK1/MAPK14/FCGR1A/IRAK1	7
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/464	77/8135	0.1485	0.3797	0.3074	ITGA6/ITGA2B/EMD/CTNNA1/PKP2/ITGA4/CACNA2D3	7
KEGG	hsa04922	Glucagon signaling pathway	9/464	107/8135	0.1562	0.3916	0.3171	GNAQ/ATF4/LDHC/PRKAG2/ITPR1/PFKP/PPP3R2/SLC2A1/LDHA	9
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	4/464	37/8135	0.1578	0.3916	0.3171	GPT2/GLUD2/GFPT1/GLUD1	4
KEGG	hsa01250	Biosynthesis of nucleotide sugars	4/464	37/8135	0.1578	0.3916	0.3171	NAGK/GALK1/GFPT1/GALT	4
KEGG	hsa04910	Insulin signaling pathway	11/464	137/8135	0.1582	0.3916	0.3171	SOCS3/SOS1/INSR/PRKAG2/PPP1R3B/PPP1CB/PIK3CA/MAP2K2/NRAS/INPP5A/FLOT1	11
KEGG	hsa04912	GnRH signaling pathway	8/464	93/8135	0.16	0.3921	0.3175	GNAQ/SOS1/ATF4/MAPK13/MAP2K2/NRAS/ITPR1/MAPK14	8
KEGG	hsa03013	Nucleocytoplasmic transport	9/464	108/8135	0.1624	0.3921	0.3175	SENP2/UPF1/RANGAP1/GLE1/NMD3/THOC7/NXT2/SUMO1/SEC13	9
KEGG	hsa01240	Biosynthesis of cofactors	12/464	153/8135	0.1631	0.3921	0.3175	BCAT1/MAT2A/PDXK/CMPK1/NMNAT3/SDR16C5/FECH/AK2/PSAT1/NADK2/NADK/COQ5	12
KEGG	hsa00270	Cysteine and methionine metabolism	5/464	51/8135	0.1637	0.3921	0.3175	BCAT1/LDHC/MAT2A/PSAT1/LDHA	5
KEGG	hsa04927	Cortisol synthesis and secretion	6/464	65/8135	0.1646	0.3921	0.3175	GNAQ/ATF4/KCNK3/SP1/ITPR1/LDLR	6
KEGG	hsa05330	Allograft rejection	4/464	38/8135	0.169	0.3974	0.3218	IL10/FAS/FASLG/IL5	4
KEGG	hsa04611	Platelet activation	10/464	124/8135	0.1694	0.3974	0.3218	RHOA/GNAQ/ITGA2B/MAPK13/PPP1CB/PIK3CA/PIK3R5/ITPR1/MAPK14/PLCG2	10
KEGG	hsa04060	Cytokine-cytokine receptor interaction	21/464	295/8135	0.1723	0.4012	0.3249	TNFSF15/IL11RA/OSM/IL1R2/IL1RAP/IL10/FAS/IL13RA1/IL36A/IL17RA/CCL1/BMP4/IL6/EPOR/ACVR2A/CTF1/FASLG/CCL20/TNFRSF8/CCR6/IL5	21
KEGG	hsa04936	Alcoholic liver disease	11/464	142/8135	0.1866	0.4312	0.3491	PRKAG2/TRAF3/MAPK13/FAS/IL17RA/IL6/MAPK14/IRAK1/TICAM1/FASLG/CASP8	11
KEGG	hsa05165	Human papillomavirus infection	23/464	331/8135	0.1882	0.4317	0.3496	MFNG/ATP6V1A/SOS1/ITGA6/ITGA2B/TRAF3/RB1/MAML3/FZD6/FAS/PIK3CA/MAP2K2/ATP6V1C1/ITGA4/NRAS/PPP2R2B/JAK1/CDK6/COL9A2/CDK2/TICAM1/FASLG/CASP8	23
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	11/464	143/8135	0.1925	0.4382	0.3549	SMAD1/MAPK13/PCGF6/FZD6/PIK3CA/MAP2K2/NRAS/JAK1/BMP4/MAPK14/ACVR2A	11
KEGG	hsa04725	Cholinergic synapse	9/464	113/8135	0.1952	0.4382	0.3549	GNAQ/KCNJ2/ATF4/BCL2/PIK3CA/PIK3R5/NRAS/ITPR1/KCNQ3	9
KEGG	hsa00564	Glycerophospholipid metabolism	8/464	98/8135	0.1952	0.4382	0.3549	ETNK1/CHKA/CHPT1/AGPAT2/DGKA/LPCAT1/ADPRM/PCYT2	8
KEGG	hsa04966	Collecting duct acid secretion	3/464	27/8135	0.1975	0.4401	0.3563	ATP6V1A/SLC4A1/ATP6V1C1	3
KEGG	hsa05211	Renal cell carcinoma	6/464	69/8135	0.1992	0.4408	0.357	SOS1/PIK3CA/MAP2K2/NRAS/ETS1/SLC2A1	6
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/464	70/8135	0.2083	0.4563	0.3695	ATP6V1A/MAPK13/ATP6V1C1/ADAM10/MAPK14/PLCG2	6
KEGG	hsa04020	Calcium signaling pathway	17/464	240/8135	0.2091	0.4563	0.3695	GNAQ/VDAC1/NTSR1/PTAFR/P2RX4/PPIF/VDAC3/SLC25A6/ADRB2/VDAC2/FGF3/TPCN1/ITPR1/PPP3R2/TACR1/PLCG2/FGF5	17
KEGG	hsa05224	Breast cancer	11/464	147/8135	0.2171	0.4679	0.3788	SOS1/RB1/FZD6/PIK3CA/MAP2K2/SP1/FGF3/NRAS/CDK6/DDB2/FGF5	11
KEGG	hsa04520	Adherens junction	6/464	71/8135	0.2174	0.4679	0.3788	RHOA/WASF1/INSR/CTNNA1/WASF2/RAC3	6
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	15/464	212/8135	0.2287	0.4887	0.3957	SOS1/ATF4/BCL2/RB1/GSTA1/EPHX3/PIK3CA/ADRB2/MAP2K2/FGF3/NRAS/PAQR7/GSTT2/FGF5/PAQR8	15
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	11/464	150/8135	0.2364	0.5017	0.4063	GNAQ/ATF4/BCL2/MAPK13/PPP1CB/ADRB2/PIK3R5/PPP2R2B/MAPK14/CACNA2D3/TPM4	11
KEGG	hsa00020	Citrate cycle (TCA cycle)	3/464	30/8135	0.2432	0.5112	0.4139	ACLY/SDHC/SUCLG2	3
KEGG	hsa04211	Longevity regulating pathway	7/464	89/8135	0.2441	0.5112	0.4139	ATF4/INSR/PRKAG2/CAT/ATG5/PIK3CA/NRAS	7
KEGG	hsa05225	Hepatocellular carcinoma	12/464	168/8135	0.2506	0.5189	0.4201	SOS1/RB1/GSTA1/FZD6/PIK3CA/MAP2K2/NRAS/SMARCE1/CDK6/GSTT2/DDB2/PLCG2	12
KEGG	hsa00910	Nitrogen metabolism	2/464	17/8135	0.2526	0.5189	0.4201	GLUD2/GLUD1	2
KEGG	hsa04919	Thyroid hormone signaling pathway	9/464	121/8135	0.2528	0.5189	0.4201	CASP9/PIK3CA/MAP2K2/NRAS/PFKP/BMP4/SLC2A1/MED27/PLCG2	9
KEGG	hsa04730	Long-term depression	5/464	60/8135	0.2562	0.5225	0.4231	GNAQ/MAP2K2/NRAS/ITPR1/GRIA2	5
KEGG	hsa00052	Galactose metabolism	3/464	31/8135	0.2588	0.5243	0.4245	GALK1/PFKP/GALT	3
KEGG	hsa04921	Oxytocin signaling pathway	11/464	154/8135	0.263	0.5295	0.4287	RHOA/GNAQ/KCNJ2/PRKAG2/PPP1CB/MAP2K2/PIK3R5/NRAS/ITPR1/PPP3R2/CACNA2D3	11
KEGG	hsa03050	Proteasome	4/464	46/8135	0.2664	0.5327	0.4314	PSMD13/PSMC3/PSMD9/PSMF1	4
KEGG	hsa04934	Cushing syndrome	11/464	155/8135	0.2699	0.5363	0.4342	GNAQ/ATF4/KCNK3/RB1/FZD6/MAP2K2/SP1/ITPR1/LDLR/CDK6/CDK2	11
KEGG	hsa04215	Apoptosis - multiple species	3/464	32/8135	0.2745	0.5388	0.4363	BCL2/CASP9/CASP8	3
KEGG	hsa05203	Viral carcinogenesis	14/464	204/8135	0.2746	0.5388	0.4363	RHOA/ATF4/TRAF3/RB1/VDAC3/YWHAE/PIK3CA/NRAS/JAK1/CDK6/HDAC7/YWHAZ/CDK2/CASP8	14
KEGG	hsa00620	Pyruvate metabolism	4/464	47/8135	0.2793	0.5446	0.4409	LDHC/LDHA/ACAT1/ME2	4
KEGG	hsa04110	Cell cycle	9/464	126/8135	0.2913	0.5646	0.4572	PTTG2/CDKN2D/ANAPC2/RB1/YWHAE/CDK6/YWHAZ/CDK2/MAD2L2	9
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	2/464	19/8135	0.2958	0.5697	0.4613	BCAT1/GPT2	2
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	4/464	49/8135	0.3053	0.5808	0.4703	NAGK/GALK1/GFPT1/GALT	4
KEGG	hsa04672	Intestinal immune network for IgA production	4/464	49/8135	0.3053	0.5808	0.4703	IL10/ITGA4/IL6/IL5	4
KEGG	hsa05168	Herpes simplex virus 1 infection	31/464	495/8135	0.3178	0.601	0.4867	ZNF573/SOCS3/ZNF621/ZNF559/ZNF610/ZNF641/ZNF77/ZNF337/BCL2/TRAF3/ZNF566/CASP9/ZNF701/PPP1CB/FAS/PIK3CA/ZNF785/ZNF248/TAPBP/ZNF514/JAK1/IL6/ZNF3/ZNF567/ZNF780B/IRAK1/TICAM1/ZNF486/FASLG/ZNF234/CASP8	31
KEGG	hsa04146	Peroxisome	6/464	82/8135	0.3255	0.6118	0.4954	ACSL3/CAT/PEX16/FAR1/ACOX2/ABCD3	6
KEGG	hsa04360	Axon guidance	12/464	182/8135	0.3441	0.6429	0.5206	RHOA/PIK3CA/DPYSL5/LRIG2/SEMA6C/CDK5/NCK2/NRAS/PPP3R2/EPHA3/PLCG2/RAC3	12
KEGG	hsa05216	Thyroid cancer	3/464	37/8135	0.354	0.6452	0.5224	MAP2K2/NRAS/DDB2	3
KEGG	hsa04012	ErbB signaling pathway	6/464	85/8135	0.3564	0.6452	0.5224	SOS1/PIK3CA/MAP2K2/NCK2/NRAS/PLCG2	6
KEGG	hsa04610	Complement and coagulation cascades	6/464	85/8135	0.3564	0.6452	0.5224	F10/CD46/F3/C8A/C6/CLU	6
KEGG	hsa05320	Autoimmune thyroid disease	4/464	53/8135	0.358	0.6452	0.5224	IL10/FAS/FASLG/IL5	4
KEGG	hsa04920	Adipocytokine signaling pathway	5/464	69/8135	0.358	0.6452	0.5224	SOCS3/ACSL3/PRKAG2/SLC2A1/ACSBG1	5
KEGG	hsa04924	Renin secretion	5/464	69/8135	0.358	0.6452	0.5224	GNAQ/KCNJ2/ADRB2/ITPR1/PPP3R2	5
KEGG	hsa00900	Terpenoid backbone biosynthesis	2/464	22/8135	0.3598	0.6452	0.5224	NUS1/ACAT1	2
KEGG	hsa04914	Progesterone-mediated oocyte maturation	7/464	102/8135	0.3633	0.6477	0.5245	ANAPC2/MAPK13/PIK3CA/STK10/MAPK14/CDK2/MAD2L2	7
KEGG	hsa04622	RIG-I-like receptor signaling pathway	5/464	70/8135	0.3696	0.6522	0.5281	TRAF3/MAPK13/ATG5/MAPK14/CASP8	5
KEGG	hsa04530	Tight junction	11/464	169/8135	0.37	0.6522	0.5281	RHOA/ARPC5/ACTR2/PRKAG2/RAB13/CTTN/PPP2R2B/ARPC4/TUBA8/CLDN15/ACTR3B	11
KEGG	hsa00515	Mannose type O-glycan biosynthesis	2/464	23/8135	0.3807	0.6599	0.5343	FKRP/B3GAT2	2
KEGG	hsa03430	Mismatch repair	2/464	23/8135	0.3807	0.6599	0.5343	MSH3/RPA1	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/464	23/8135	0.3807	0.6599	0.5343	GLUD2/GLUD1	2
KEGG	hsa00513	Various types of N-glycan biosynthesis	3/464	39/8135	0.3857	0.6648	0.5383	MAN1A1/MGAT4A/MGAT2	3
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	7/464	106/8135	0.4012	0.6878	0.557	RHOA/GNAQ/PDE4D/ATF4/BCL2/SP1/ITPR1	7
KEGG	hsa01212	Fatty acid metabolism	4/464	57/8135	0.4106	0.7	0.5668	ACSL3/ACSBG1/HSD17B12/ACAT1	4
KEGG	hsa04062	Chemokine signaling pathway	12/464	192/8135	0.4145	0.7029	0.5692	RHOA/GNAQ/SOS1/VAV1/PIK3CA/PIK3R5/NRAS/CCL1/PLCG2/CCL20/CCR6/RAC3	12
KEGG	hsa05219	Bladder cancer	3/464	41/8135	0.4169	0.7032	0.5694	RB1/MAP2K2/NRAS	3
KEGG	hsa00480	Glutathione metabolism	4/464	58/8135	0.4236	0.7106	0.5754	NAT8B/GSTA1/GSR/GSTT2	4
KEGG	hsa04658	Th1 and Th2 cell differentiation	6/464	92/8135	0.4288	0.7154	0.5793	MAPK13/MAML3/JAK1/PPP3R2/MAPK14/IL5	6
KEGG	hsa05332	Graft-versus-host disease	3/464	42/8135	0.4324	0.7176	0.581	FAS/IL6/FASLG	3
KEGG	hsa04330	Notch signaling pathway	4/464	59/8135	0.4366	0.7207	0.5836	MFNG/APH1A/MAML3/ATXN1L	4
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/464	26/8135	0.4415	0.7237	0.586	PIGG/PIGC	2
KEGG	hsa04380	Osteoclast differentiation	8/464	128/8135	0.4476	0.7237	0.586	SOCS3/MAPK13/PIK3CA/JAK1/PPP3R2/MAPK14/FCGR1A/PLCG2	8
KEGG	hsa00071	Fatty acid degradation	3/464	43/8135	0.4477	0.7237	0.586	ACSL3/ACSBG1/ACAT1	3
KEGG	hsa04940	Type I diabetes mellitus	3/464	43/8135	0.4477	0.7237	0.586	CPE/FAS/FASLG	3
KEGG	hsa04714	Thermogenesis	14/464	232/8135	0.4535	0.7257	0.5876	SOS1/NDUFAF5/ACSL3/COX5A/SDHC/UQCRC2/PRKAG2/MAPK13/UQCRC1/NRAS/SMARCE1/MAPK14/COA3/NDUFA5	14
KEGG	hsa05171	Coronavirus disease - COVID-19	14/464	232/8135	0.4535	0.7257	0.5876	TRAF3/RPS27L/MAPK13/RPS4Y1/PIK3CA/C8A/JAK1/IL6/MAPK14/IRAK1/C6/RPS4X/RPL22L1/PLCG2	14
KEGG	hsa05150	Staphylococcus aureus infection	6/464	96/8135	0.4697	0.7379	0.5975	PTAFR/IL10/KRT37/KRT32/FPR2/FCGR1A	6
KEGG	hsa05414	Dilated cardiomyopathy	6/464	96/8135	0.4697	0.7379	0.5975	ITGA6/ITGA2B/EMD/ITGA4/CACNA2D3/TPM4	6
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/464	11/8135	0.4761	0.7379	0.5975	COQ5	1
KEGG	hsa04724	Glutamatergic synapse	7/464	114/8135	0.4767	0.7379	0.5975	GNAQ/SLC38A1/HOMER3/ITPR1/PPP3R2/GRIA2/SHANK1	7
KEGG	hsa03022	Basal transcription factors	3/464	45/8135	0.4777	0.7379	0.5975	TAF1L/TAF11/TAF6	3
KEGG	hsa04510	Focal adhesion	12/464	201/8135	0.4782	0.7379	0.5975	RHOA/SOS1/ITGA6/ITGA2B/VAV1/BCL2/PPP1CB/PIK3CA/ITGA4/COL9A2/PIP5K1A/RAC3	12
KEGG	hsa04514	Cell adhesion molecules	9/464	149/8135	0.4793	0.7379	0.5975	ALCAM/SDC4/ITGA6/PECAM1/CD99/PTPRC/ITGA4/CLDN15/VCAN	9
KEGG	hsa00650	Butanoate metabolism	2/464	28/8135	0.4801	0.7379	0.5975	ACSM1/ACAT1	2
KEGG	hsa04728	Dopaminergic synapse	8/464	132/8135	0.4824	0.7379	0.5975	GNAQ/ATF4/MAPK13/PPP1CB/ITPR1/PPP2R2B/MAPK14/GRIA2	8
KEGG	hsa04930	Type II diabetes mellitus	3/464	46/8135	0.4925	0.7496	0.6069	SOCS3/INSR/PIK3CA	3
KEGG	hsa03420	Nucleotide excision repair	3/464	47/8135	0.507	0.7679	0.6218	RAD23B/RPA1/DDB2	3
KEGG	hsa00030	Pentose phosphate pathway	2/464	30/8135	0.517	0.7756	0.628	PFKP/PRPS1	2
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	2/464	30/8135	0.517	0.7756	0.628	CAT/ACAT1	2
KEGG	hsa04152	AMPK signaling pathway	7/464	120/8135	0.5316	0.7843	0.6351	INSR/PRKAG2/STRADB/PIK3CA/ELAVL1/PPP2R2B/PFKP	7
KEGG	hsa04710	Circadian rhythm	2/464	31/8135	0.5349	0.7843	0.6351	PRKAG2/BHLHE40	2
KEGG	hsa05310	Asthma	2/464	31/8135	0.5349	0.7843	0.6351	IL10/IL5	2
KEGG	hsa00565	Ether lipid metabolism	3/464	49/8135	0.5354	0.7843	0.6351	GDPD3/CHPT1/LPCAT1	3
KEGG	hsa05030	Cocaine addiction	3/464	49/8135	0.5354	0.7843	0.6351	ATF4/CDK5/GRIA2	3
KEGG	hsa04371	Apelin signaling pathway	8/464	139/8135	0.5419	0.7887	0.6387	GNAQ/PRKAG2/PIK3C3/MAP2K2/PIK3R5/NRAS/ITPR1/PIK3R4	8
KEGG	hsa05202	Transcriptional misregulation in cancer	11/464	193/8135	0.546	0.7887	0.6387	FLT3/FLI1/SMAD1/HPGD/IL1R2/SP1/IL6/ZBTB16/FCGR1A/DDB2/SS18	11
KEGG	hsa04064	NF-kappa B signaling pathway	6/464	104/8135	0.5487	0.7887	0.6387	BCL2/TRAF3/EDARADD/IRAK1/TICAM1/PLCG2	6
KEGG	hsa05144	Malaria	3/464	50/8135	0.5493	0.7887	0.6387	PECAM1/IL10/IL6	3
KEGG	hsa03010	Ribosome	9/464	158/8135	0.5511	0.7887	0.6387	MRPL15/RPS27L/RPS4Y1/MRPS12/MRPS6/MRPS15/RPS4X/RPL22L1/MRPL3	9
KEGG	hsa04260	Cardiac muscle contraction	5/464	87/8135	0.5588	0.7918	0.6411	COX5A/UQCRC2/UQCRC1/CACNA2D3/TPM4	5
KEGG	hsa05031	Amphetamine addiction	4/464	69/8135	0.5601	0.7918	0.6411	ATF4/PPP1CB/PPP3R2/GRIA2	4
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/464	14/8135	0.5608	0.7918	0.6411	B3GNT2	1
KEGG	hsa04512	ECM-receptor interaction	5/464	88/8135	0.5691	0.7962	0.6447	SDC4/ITGA6/ITGA2B/ITGA4/COL9A2	5
KEGG	hsa04130	SNARE interactions in vesicular transport	2/464	33/8135	0.5691	0.7962	0.6447	VAMP3/YKT6	2
KEGG	hsa00600	Sphingolipid metabolism	3/464	52/8135	0.5763	0.8026	0.6499	SPTLC1/CERS6/ACER3	3
KEGG	hsa00730	Thiamine metabolism	1/464	15/8135	0.5859	0.8093	0.6553	AK2	1
KEGG	hsa04659	Th17 cell differentiation	6/464	108/8135	0.5862	0.8093	0.6553	MAPK13/IL1RAP/JAK1/IL6/PPP3R2/MAPK14	6
KEGG	hsa00230	Purine metabolism	7/464	128/8135	0.601	0.826	0.6688	PDE4D/ENTPD2/HDDC2/PAPSS1/AK2/ADPRM/PRPS1	7
KEGG	hsa04926	Relaxin signaling pathway	7/464	129/8135	0.6093	0.8285	0.6709	SOS1/ATF4/MAPK13/PIK3CA/MAP2K2/NRAS/MAPK14	7
KEGG	hsa04024	cAMP signaling pathway	12/464	221/8135	0.6131	0.8285	0.6709	RHOA/PDE4D/ARAP3/VAV1/PPP1CB/PIK3CA/ADRB2/MAP2K2/FFAR2/GRIA2/SSTR2/RAC3	12
KEGG	hsa04723	Retrograde endocannabinoid signaling	8/464	148/8135	0.6141	0.8285	0.6709	GNAQ/MAPK13/GABRB2/ITPR1/MAPK14/GRIA2/ABHD6/NDUFA5	8
KEGG	hsa00512	Mucin type O-glycan biosynthesis	2/464	36/8135	0.617	0.8285	0.6709	GCNT3/GALNT15	2
KEGG	hsa04970	Salivary secretion	5/464	93/8135	0.6187	0.8285	0.6709	GNAQ/SLC12A2/ADRB2/ITPR1/HTN3	5
KEGG	hsa03320	PPAR signaling pathway	4/464	75/8135	0.6267	0.8285	0.6709	ACSL3/ACOX2/GK/ACSBG1	4
KEGG	hsa04923	Regulation of lipolysis in adipocytes	3/464	56/8135	0.6271	0.8285	0.6709	INSR/PIK3CA/ADRB2	3
KEGG	hsa04350	TGF-beta signaling pathway	5/464	94/8135	0.6282	0.8285	0.6709	RHOA/SMAD1/SP1/BMP4/ACVR2A	5
KEGG	hsa00120	Primary bile acid biosynthesis	1/464	17/8135	0.6319	0.8285	0.6709	ACOX2	1
KEGG	hsa00450	Selenocompound metabolism	1/464	17/8135	0.6319	0.8285	0.6709	PAPSS1	1
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	2/464	37/8135	0.632	0.8285	0.6709	INSR/PIK3CA	2
KEGG	hsa04971	Gastric acid secretion	4/464	76/8135	0.6372	0.8318	0.6735	GNAQ/KCNJ2/ITPR1/SSTR2	4
KEGG	hsa04726	Serotonergic synapse	6/464	115/8135	0.6477	0.8406	0.6807	GNAQ/DUSP1/GABRB2/NRAS/ITPR1/ALOX15B	6
KEGG	hsa00190	Oxidative phosphorylation	7/464	134/8135	0.6493	0.8406	0.6807	ATP6V1A/COX5A/SDHC/UQCRC2/UQCRC1/ATP6V1C1/NDUFA5	7
KEGG	hsa00511	Other glycan degradation	1/464	18/8135	0.6529	0.8418	0.6816	ENGASE	1
KEGG	hsa04612	Antigen processing and presentation	4/464	78/8135	0.6575	0.8442	0.6836	HSPA6/TAPBP/NFYC/HSPA5	4
KEGG	hsa04925	Aldosterone synthesis and secretion	5/464	98/8135	0.6648	0.8501	0.6884	GNAQ/ATF4/KCNK3/ITPR1/LDLR	5
KEGG	hsa05416	Viral myocarditis	3/464	60/8135	0.6735	0.8542	0.6916	CASP9/CASP8/RAC3	3
KEGG	hsa05033	Nicotine addiction	2/464	40/8135	0.6743	0.8542	0.6916	GABRB2/GRIA2	2
KEGG	hsa04390	Hippo signaling pathway	8/464	157/8135	0.6798	0.8542	0.6916	SMAD1/CTNNA1/PPP1CB/FZD6/YWHAE/PPP2R2B/BMP4/YWHAZ	8
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/464	100/8135	0.6822	0.8542	0.6916	IL10/CCL1/IL6/CCL20/CCR6	5
KEGG	hsa00140	Steroid hormone biosynthesis	3/464	61/8135	0.6844	0.8542	0.6916	STS/HSD17B12/SULT1E1	3
KEGG	hsa00561	Glycerolipid metabolism	3/464	61/8135	0.6844	0.8542	0.6916	AGPAT2/DGKA/GK	3
KEGG	hsa03440	Homologous recombination	2/464	41/8135	0.6875	0.8546	0.692	BLM/RPA1	2
KEGG	hsa00100	Steroid biosynthesis	1/464	20/8135	0.6915	0.8561	0.6932	DHCR7	1
KEGG	hsa04972	Pancreatic secretion	5/464	102/8135	0.699	0.8602	0.6965	RHOA/GNAQ/SLC12A2/ITPR1/RAB3D	5
KEGG	hsa00380	Tryptophan metabolism	2/464	42/8135	0.7003	0.8602	0.6965	CAT/ACAT1	2
KEGG	hsa05217	Basal cell carcinoma	3/464	63/8135	0.7055	0.8618	0.6978	FZD6/BMP4/DDB2	3
KEGG	hsa00770	Pantothenate and CoA biosynthesis	1/464	21/8135	0.7091	0.8618	0.6978	BCAT1	1
KEGG	hsa00860	Porphyrin metabolism	2/464	43/8135	0.7126	0.8618	0.6978	HEPH/FECH	2
KEGG	hsa04975	Fat digestion and absorption	2/464	43/8135	0.7126	0.8618	0.6978	AGPAT2/ACAT1	2
KEGG	hsa01232	Nucleotide metabolism	4/464	85/8135	0.7225	0.8704	0.7048	ENTPD2/HDDC2/CMPK1/AK2	4
KEGG	hsa05321	Inflammatory bowel disease	3/464	65/8135	0.7254	0.8705	0.7048	IL10/IL6/IL5	3
KEGG	hsa02010	ABC transporters	2/464	45/8135	0.736	0.8796	0.7122	ABCB10/ABCD3	2
KEGG	hsa03040	Spliceosome	7/464	147/8135	0.7414	0.8796	0.7122	PRPF31/SNRPE/HSPA6/U2AF2/WBP11/CDC5L/ISY1	7
KEGG	hsa04614	Renin-angiotensin system	1/464	23/8135	0.7414	0.8796	0.7122	ATP6AP2	1
KEGG	hsa04310	Wnt signaling pathway	8/464	167/8135	0.7443	0.8796	0.7122	RHOA/TBL1XR1/SENP2/FZD6/PPP3R2/RSPO3/RUVBL1/RAC3	8
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	5/464	109/8135	0.7529	0.8864	0.7177	XRN2/GNL3/NMD3/NXT2/NOB1	5
KEGG	hsa00514	Other types of O-glycan biosynthesis	2/464	47/8135	0.7577	0.8887	0.7196	MFNG/GALNT15	2
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	3/464	69/8135	0.7621	0.8905	0.7211	GSTA1/GSTT2/CYP3A43	3
KEGG	hsa00280	Valine, leucine and isoleucine degradation	2/464	48/8135	0.768	0.8941	0.724	BCAT1/ACAT1	2
KEGG	hsa04270	Vascular smooth muscle contraction	6/464	134/8135	0.7842	0.9038	0.7318	PRKCH/RHOA/GNAQ/PPP1CB/MAP2K2/ITPR1	6
KEGG	hsa05323	Rheumatoid arthritis	4/464	93/8135	0.7851	0.9038	0.7318	ATP6V1A/ATP6V1C1/IL6/CCL20	4
KEGG	hsa00062	Fatty acid elongation	1/464	27/8135	0.7957	0.9038	0.7318	HSD17B12	1
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/464	27/8135	0.7957	0.9038	0.7318	B3GNT2	1
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	1/464	27/8135	0.7957	0.9038	0.7318	HSD17B12	1
KEGG	hsa00330	Arginine and proline metabolism	2/464	51/8135	0.7966	0.9038	0.7318	OAT/SAT2	2
KEGG	hsa04913	Ovarian steroidogenesis	2/464	51/8135	0.7966	0.9038	0.7318	INSR/LDLR	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	1/464	29/8135	0.8184	0.9252	0.7491	RASSF4	1
KEGG	hsa03460	Fanconi anemia pathway	2/464	54/8135	0.822	0.9259	0.7497	BLM/RPA1	2
KEGG	hsa01523	Antifolate resistance	1/464	30/8135	0.8288	0.9284	0.7517	IL6	1
KEGG	hsa04721	Synaptic vesicle cycle	3/464	78/8135	0.8302	0.9284	0.7517	ATP6V1A/NAPA/ATP6V1C1	3
KEGG	hsa04916	Melanogenesis	4/464	101/8135	0.8359	0.9297	0.7528	GNAQ/FZD6/MAP2K2/NRAS	4
KEGG	hsa04340	Hedgehog signaling pathway	2/464	56/8135	0.8373	0.9297	0.7528	BCL2/MGRN1	2
KEGG	hsa00983	Drug metabolism - other enzymes	3/464	80/8135	0.8428	0.9325	0.755	GSTA1/CMPK1/GSTT2	3
KEGG	hsa00240	Pyrimidine metabolism	2/464	58/8135	0.8515	0.9387	0.7601	HDDC2/CMPK1	2
KEGG	hsa00051	Fructose and mannose metabolism	1/464	33/8135	0.8566	0.941	0.762	PFKP	1
KEGG	hsa04911	Insulin secretion	3/464	86/8135	0.876	0.9522	0.771	GNAQ/ATF4/SLC2A1	3
KEGG	hsa04142	Lysosome	5/464	132/8135	0.8794	0.9522	0.771	TPP1/GM2A/SORT1/LAMP3/AP1S2	5
KEGG	hsa00500	Starch and sucrose metabolism	1/464	36/8135	0.8798	0.9522	0.771	GYG1	1
KEGG	hsa03030	DNA replication	1/464	36/8135	0.8798	0.9522	0.771	RPA1	1
KEGG	hsa04623	Cytosolic DNA-sensing pathway	2/464	63/8135	0.882	0.9522	0.771	IL6/RIPK3	2
KEGG	hsa04727	GABAergic synapse	3/464	89/8135	0.8901	0.9576	0.7754	SLC38A1/PLCL1/GABRB2	3
KEGG	hsa05340	Primary immunodeficiency	1/464	38/8135	0.8932	0.9577	0.7754	PTPRC	1
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	2/464	66/8135	0.8975	0.9589	0.7765	DARS2/IARS2	2
KEGG	hsa00260	Glycine, serine and threonine metabolism	1/464	40/8135	0.9051	0.9622	0.7791	PSAT1	1
KEGG	hsa00830	Retinol metabolism	2/464	68/8135	0.9067	0.9622	0.7791	PNPLA4/SDR16C5	2
KEGG	hsa04713	Circadian entrainment	3/464	97/8135	0.921	0.9727	0.7876	GNAQ/ITPR1/GRIA2	3
KEGG	hsa00982	Drug metabolism - cytochrome P450	2/464	72/8135	0.9228	0.9727	0.7876	GSTA1/GSTT2	2
KEGG	hsa04973	Carbohydrate digestion and absorption	1/464	47/8135	0.9372	0.9819	0.7951	PIK3CA	1
KEGG	hsa04974	Protein digestion and absorption	3/464	103/8135	0.9387	0.9819	0.7951	SLC36A4/SLC3A2/COL9A2	3
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/464	78/8135	0.9422	0.9819	0.7951	GSTA1/GSTT2	2
KEGG	hsa04080	Neuroactive ligand-receptor interaction	14/464	353/8135	0.9465	0.9819	0.7951	NTSR1/PTAFR/MCHR2/P2RX4/ADRB2/UCN/GABRB2/KISS1R/P2RY13/FPR2/NPFF/GRIA2/TACR1/SSTR2	14
KEGG	hsa05322	Systemic lupus erythematosus	4/464	136/8135	0.9559	0.9819	0.7951	IL10/C8A/FCGR1A/C6	4
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/464	53/8135	0.956	0.9819	0.7951	GNAQ	1
KEGG	hsa04742	Taste transduction	2/464	86/8135	0.961	0.9819	0.7951	TAS2R40/ENTPD2	2
KEGG	hsa04976	Bile secretion	2/464	89/8135	0.9664	0.9819	0.7951	LDLR/SLC2A1	2
KEGG	hsa05032	Morphine addiction	2/464	91/8135	0.9696	0.9819	0.7951	PDE4D/GABRB2	2
KEGG	hsa05206	MicroRNAs in cancer	11/464	310/8135	0.9706	0.9819	0.7951	RHOA/SOS1/BCL2/SPRY2/PIK3CA/MAP2K2/NRAS/CDK6/DDIT4/CCNG1/PLCG2	11
KEGG	hsa04978	Mineral absorption	1/464	60/8135	0.9709	0.9819	0.7951	HEPH	1
KEGG	hsa00590	Arachidonic acid metabolism	1/464	61/8135	0.9726	0.9819	0.7951	ALOX15B	1
KEGG	hsa00310	Lysine degradation	1/464	63/8135	0.9756	0.9819	0.7951	ACAT1	1
KEGG	hsa03250	Viral life cycle - HIV-1	1/464	63/8135	0.9756	0.9819	0.7951	CHMP4B	1
KEGG	hsa05034	Alcoholism	5/464	187/8135	0.9843	0.9875	0.7996	SOS1/ATF4/PPP1CB/NRAS/HDAC7	5
KEGG	hsa04740	Olfactory transduction	2/464	440/8135	1	1	0.8097	SLC24A4/OR3A2	2