ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04142	Lysosome	62/1542	132/8135	1.554e-13	5.143e-11	2.666e-11	MAN2B1/GAA/FUCA1/TPP1/NAGLU/ACP5/NAGPA/SGSH/CTSA/AP1B1/GLA/CD63/ATP6V0A1/SMPD1/NPC1/AP1S2/ATP6V0C/DNASE2/CD164/CTSC/ARSA/CTSK/ASAH1/GM2A/CLN5/TCIRG1/CLTB/CLTA/AP3S1/PLA2G15/AP1S1/AP1G2/LAMP3/CTSD/GALC/ATP6AP1/CLN3/NPC2/CTNS/LGMN/DMXL1/AP3D1/LAPTM4B/ATP6V1H/PSAP/HEXA/AP4M1/NEU1/CTSZ/CTSF/LITAF/PPT1/CTSH/CTSE/IDS/SORT1/DMXL2/HYAL2/WDR7/CTSL/ABCB9/ATP6V0D1	62
KEGG	hsa04210	Apoptosis	61/1542	136/8135	3.047e-12	5.042e-10	2.614e-10	BCL2A1/ATM/TNFRSF1A/JUN/ATF4/MAPK3/ITPR2/TP53/MCL1/AKT1/CTSC/CTSK/DDIT3/PIK3CD/CASP3/LMNB2/PARP4/GADD45A/MAP2K2/IL3RA/PMAIP1/MAP3K14/BIRC3/HRAS/CAPN2/KRAS/CTSD/IKBKB/FAS/BAK1/CFLAR/ITPR3/GADD45B/PARP2/BAD/CHUK/PARP1/CYCS/CASP7/CAPN1/CASP10/TNFSF10/MAP2K1/LMNA/CTSZ/AIFM1/DFFA/CTSF/FADD/AKT2/CTSH/FASLG/TRADD/PIK3R2/SPTAN1/SPTA1/PIK3CB/TRAF1/CTSL/MAPK10/GZMB	61
KEGG	hsa05169	Epstein-Barr virus infection	77/1542	202/8135	9.514e-11	1.05e-08	5.442e-09	CCND2/HLA-DMB/OAS2/JUN/CCNA1/BTK/TYK2/HES1/CDKN1A/RBPJ/CIR1/TP53/AKT1/HLA-DMA/IFNAR1/PIK3CD/CASP3/IFNAR2/CD3D/TNFAIP3/STAT2/GADD45A/VIM/MAP3K14/PSMD3/HDAC1/PSMD11/SYK/TAP1/IKBKB/FAS/HLA-DOB/NFKB2/CD3G/BAK1/MAPK14/IFNA2/CDK2/CDK4/SNW1/BLNK/GADD45B/CCND1/PSMD14/RB1/CHUK/IRF3/RELB/CYCS/IRAK1/STAT1/NFKBIB/HLA-DQB1/PSMC6/CD44/PDIA3/PSMC1/FADD/IKBKE/AKT2/ADRM1/CD247/TRADD/PIK3R2/TRAF6/CCNA2/PIK3CB/HLA-A/PSMC4/MAP2K3/MAPK10/ITGAL/RAC1/MAPK13/PSMD13/NCOR2/PSMD8	77
KEGG	hsa05221	Acute myeloid leukemia	36/1542	67/8135	1.759e-10	1.456e-08	7.545e-09	CSF1R/BCL2A1/CCNA1/MAPK3/PIM1/SPI1/ITGAM/AKT1/CEBPA/PIK3CD/PPARD/CD14/MAP2K2/PER2/PML/HRAS/KRAS/IKBKB/ARAF/SOS1/RPS6KB2/MTOR/GRB2/BAD/CCND1/PIM2/CHUK/CSF2/MAP2K1/AKT2/PIK3R2/JUP/DUSP6/CCNA2/PIK3CB/STAT5A	36
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	81/1542	222/8135	3.827e-10	2.483e-08	1.287e-08	CCND2/CD4/ATM/ETS2/HLA-DMB/TNFRSF1A/JUN/ATF4/CCNA1/CDKN1A/MAPK3/CREBBP/CREB1/SPI1/ADCY3/TP53/IL1R2/AKT1/ANAPC15/HLA-DMA/IL2RG/LTBR/PIK3CD/SLC25A6/CD3D/MAP2K2/PTTG1/MAP3K14/ESPL1/ANAPC13/IL15/ANAPC5/HRAS/MAD2L1/KRAS/TLN1/IKBKB/HLA-DOB/NFKB2/CD3G/ITGB2/EGR2/SRF/IL2RB/CDK2/IL1R1/PPP3CC/TRRAP/CDK4/ADCY9/CCND1/CDC16/RB1/FDPS/CHUK/CHEK1/RELB/CSF2/CRTC1/MAP2K1/GPS2/HLA-DQB1/PRKACB/KAT2A/CDKN2A/TGFB2/RAN/KAT2B/AKT2/LCK/PIK3R2/TBPL1/CCNA2/PIK3CB/HLA-A/ATR/MAPK10/ELK4/KAT5/ITGAL/STAT5A	81
KEGG	hsa05165	Human papillomavirus infection	109/1542	331/8135	4.501e-10	2.483e-08	1.287e-08	CCND2/SPP1/ATM/TNFRSF1A/TADA3/TSC2/ITGB7/CCNA1/RHEB/TYK2/HES1/CDKN1A/RBPJ/ATP6V0A1/MAPK3/CREBBP/CREB1/ATP6V0C/NFX1/TP53/AKT1/PPP2R1A/IFNAR1/LAMB2/VEGFA/PPP2R2A/ITGB1/ITGB5/PIK3CD/TCIRG1/CASP3/CSNK1A1/NOTCH3/IFNAR2/FZD2/RBL2/STAT2/FN1/MAP2K2/NOTCH2/RFNG/ITGA7/ATP6V1A/COL4A1/LAMC1/HDAC1/THBS1/HRAS/PTK2/PTGS2/KRAS/CDC42/MFNG/IKBKB/FAS/ATP6AP1/SOS1/GNAS/RPS6KB2/MTOR/BAK1/SCRIB/ATP6V1B2/FZD7/IFNA2/IRF1/ITGA1/PRKCI/ATP6V1G1/CDK2/GRB2/CDK4/BAD/MX2/CCND1/RB1/CHUK/IRF3/ATP6V1H/CTNNB1/MAP2K1/STAT1/ATP6V1D/PRKACB/ATP6V1E1/PSMC1/FADD/IKBKE/AKT2/PPP2R5D/FASLG/TRADD/DVL3/PIK3R2/LAMA2/TBPL1/FZD5/CCNA2/ATP6V0E2/PIK3CB/ITGB8/HLA-A/MX1/BCAP31/FZD6/ATR/MAGI1/COL4A4/ATP6V0D1	109
KEGG	hsa04380	Osteoclast differentiation	52/1542	128/8135	8.881e-09	4.199e-07	2.177e-07	NCF4/CSF1R/ACP5/TNFRSF1A/JUN/BTK/TYK2/MAPK3/LILRB5/CREB1/SPI1/PPARG/TYROBP/FYN/AKT1/IFNAR1/CTSK/FCGR3A/PIK3CD/IFNAR2/IFNG/STAT2/MAP3K14/SYK/LILRA3/IKBKB/NFKB2/MAPK14/GRB2/IL1R1/PPP3CC/LILRB4/BLNK/TNFSF11/CHUK/RELB/FOSL2/MAP2K1/STAT1/TGFB2/AKT2/LCK/PIK3R2/SIRPA/TRAF6/PIK3CB/MAPK10/LCP2/TNFRSF11A/RAC1/CSF1/MAPK13	52
KEGG	hsa04010	MAPK signaling pathway	95/1542	294/8135	1.81e-08	7.491e-07	3.883e-07	IGF1/FLT1/CSF1R/RPS6KA2/DUSP4/TNFRSF1A/JUN/ATF4/VEGFB/ARRB2/MAPK3/RAPGEF2/RAP1B/TP53/MAP3K11/AKT1/DUSP10/MKNK1/DDIT3/VEGFA/HSPA6/CASP3/HSPA8/RPS6KA4/DUSP5/FLNB/CD14/GADD45A/MAP2K2/IL1RAP/MAP3K14/PPM1A/HRAS/KRAS/CDC42/MAP4K2/IKBKB/ARAF/FAS/AREG/DUSP3/SOS1/NFKB2/PDGFB/SRF/GNG12/HGF/MAPK14/EREG/RRAS/GRB2/IL1R1/PPP3CC/FGF9/PDGFA/GADD45B/RASGRF1/MAP3K8/FGF1/GNA12/CHUK/RELB/MAP4K4/IRAK1/HSPA1B/MAP2K1/PRKACB/MKNK2/MAPK8IP3/ERBB4/TGFB2/AKT2/MAPK7/NR4A1/FASLG/TRADD/FGFR1/MAP3K4/RPS6KA3/DUSP6/TRAF6/NF1/FGF7/CDC25B/MAP2K3/MAPK10/MET/ELK4/RAC1/MAP4K1/CSF1/PLA2G4A/RASGRP1/TAOK3/MAPK13	95
KEGG	hsa05163	Human cytomegalovirus infection	77/1542	225/8135	2.787e-08	1.025e-06	5.314e-07	TNFRSF1A/GNAI2/TSC2/ATF4/RHEB/CDKN1A/MAPK3/ITPR2/CREB1/ADCY3/GNG7/TP53/GNG5/AKT1/ARHGEF11/PLCB3/IL10RA/ROCK1/VEGFA/AKAP13/PIK3CD/CASP3/MAP2K2/PLCB2/HRAS/PTK2/PTGS2/KRAS/TAP1/GNB2/IKBKB/FAS/SOS1/GNAS/RPS6KB2/MTOR/RHOA/PTGER3/CCR5/BAK1/GNG12/MAPK14/IFNA2/GNAI1/GRB2/IL1R1/ITPR3/PPP3CC/CDK4/ADCY9/CCND1/RB1/GNA12/CHUK/IRF3/CYCS/CTNNB1/MAP2K1/PRKACB/CXCL8/CDKN2A/PDIA3/FADD/AKT2/FASLG/CCL2/TRADD/PIK3R2/PIK3CB/HLA-A/CXCL12/CCL3/ROCK2/PTGER2/RAC1/GNAO1/MAPK13	77
KEGG	hsa05212	Pancreatic cancer	35/1542	76/8135	5.941e-08	1.966e-06	1.019e-06	ARHGEF6/PLD2/CDKN1A/MAPK3/TP53/AKT1/VEGFA/PIK3CD/GADD45A/PLD1/KRAS/RALA/CDC42/IKBKB/ARAF/RPS6KB2/MTOR/BAK1/CDK4/GADD45B/BAD/CCND1/RB1/CHUK/MAP2K1/STAT1/CDKN2A/TGFB2/AKT2/PIK3R2/PIK3CB/RAD51/MAPK10/RAC1/RALBP1	35
KEGG	hsa05323	Rheumatoid arthritis	40/1542	93/8135	7.223e-08	2.173e-06	1.127e-06	FLT1/HLA-DMB/ACP5/JUN/ATP6V0A1/ATP6V0C/HLA-DMA/CTSK/VEGFA/TCIRG1/CD80/IFNG/ATP6V1A/IL15/CCL20/ATP6AP1/HLA-DOB/ITGB2/ATP6V1B2/ATP6V1G1/TNFSF11/MMP1/CSF2/ATP6V1H/HLA-DQB1/ATP6V1D/ATP6V1E1/CXCL8/CD28/TGFB2/CCL2/ATP6V0E2/CXCL12/CTSL/CCL3/ITGAL/TNFRSF11A/CSF1/MMP3/ATP6V0D1	40
KEGG	hsa05417	Lipid and atherosclerosis	73/1542	215/8135	9.241e-08	2.549e-06	1.321e-06	NCF4/VAV1/TNFRSF1A/JUN/ATF4/CYP1A1/MAPK3/PPARG/RAP1B/TP53/AKT1/PLCB3/DDIT3/POU2F1/HSPA6/PIK3CD/CASP3/HSPA8/CD14/MMP9/RXRA/PLCB2/HSP90AB1/NLRP3/TANK/HRAS/PTK2/KRAS/CDC42/IKBKB/FAS/VLDLR/XBP1/RHOA/HSP90AA1/MAPK14/IFNA2/PPP3CC/BAD/MMP1/CHUK/OLR1/IRF3/CYCS/CASP7/LY96/TNFSF10/IRAK1/HSPA1B/CXCL8/IKBKE/AKT2/RXRB/FASLG/CCL2/PIK3R2/CAMK2G/CYP2C8/CD36/TRAF6/HSPD1/PIK3CB/ABCG1/HSPA4/MAP2K3/CCL3/MAPK10/ROCK2/NFE2L2/RAC1/CYP2A6/MMP3/MAPK13	73
KEGG	hsa05170	Human immunodeficiency virus 1 infection	72/1542	212/8135	1.119e-07	2.85e-06	1.477e-06	CD4/ATM/DDB1/TNFRSF1A/GNAI2/JUN/AP1B1/MAPK3/ITPR2/AP1S2/GNG7/GNG5/AKT1/CUL4B/CFL1/PIK3CD/CASP3/CD3D/APOBEC3B/MAP2K2/WEE1/APOBEC3F/HRAS/PTK2/KRAS/TAP1/AP1S1/AP1G2/GNB2/IKBKB/FAS/RPS6KB2/MTOR/CD3G/CCR5/BAK1/CUL4A/GNG12/MAPK14/IFNA2/GNAI1/ITPR3/PPP3CC/APOBEC3C/BAD/CHUK/CHEK1/IRF3/CYCS/SAMHD1/IRAK1/MAP2K1/CUL1/PDIA3/BST2/FADD/AKT2/FASLG/CD247/TRADD/PIK3R2/TRAF6/PIK3CB/HLA-A/MAP2K3/ATR/MAPK10/CCNB1/CDK1/RAC1/GNAO1/MAPK13	72
KEGG	hsa04110	Cell cycle	49/1542	126/8135	1.227e-07	2.902e-06	1.504e-06	CCND2/ATM/DBF4/CCNA1/MCM5/YWHAQ/CDKN1A/CREBBP/TP53/ANAPC15/ABL1/RBL2/ORC3/GADD45A/E2F4/PTTG1/WEE1/ESPL1/ANAPC13/HDAC1/ANAPC5/MAD2L1/PRKDC/CDK7/MCM2/PCNA/CDK2/CDK4/GADD45B/CCND1/CDC16/RB1/CHEK1/CCNH/RAD21/CUL1/CDKN2A/TGFB2/MCM6/ORC5/CCNA2/YWHAH/CDC25B/YWHAB/ATR/CCNB1/CDK1/ORC1/CDC6	49
KEGG	hsa04510	Focal adhesion	68/1542	201/8135	2.978e-07	6.571e-06	3.406e-06	CCND2/SPP1/IGF1/DIAPH1/FLT1/ZYX/VAV1/PIP5K1C/JUN/ITGB7/VEGFB/ILK/MAPK3/RAP1B/FYN/AKT1/LAMB2/ROCK1/VEGFA/ITGB1/ITGB5/PIK3CD/PARVB/FLNB/CAV1/FN1/BIRC3/ITGA7/COL4A1/LAMC1/RAPGEF1/THBS1/HRAS/PTK2/CAPN2/TLN1/CDC42/SOS1/RHOA/MYLK/ARHGAP35/PDGFB/HGF/PIP5K1A/ITGA1/GRB2/PDGFA/BAD/CCND1/RASGRF1/CTNNB1/MAP2K1/AKT2/PIK3R2/PPP1CB/ACTN4/LAMA2/PIK3CB/ITGB8/MAPK10/MET/ROCK2/RAC1/PPP1R12A/SHC2/COL4A4/ARHGAP5/MYL12B	68
KEGG	hsa05131	Shigellosis	79/1542	247/8135	4.71e-07	9.37e-06	4.857e-06	DIAPH1/ATM/TNFRSF1A/JUN/MAP1LC3B/HCLS1/HK2/ATG12/ILK/MAPK3/ITPR2/UBE2D3/ARF6/TP53/AKT1/PLCB3/CAPNS1/ROCK1/PFN1/ITGB1/PIK3CD/CASP4/RRAGD/NAIP/TLR5/CD14/PLCB2/ELMO1/NLRP3/PTK2/PFN2/CAPN2/MALT1/TLN1/CDC42/IKBKB/CALCOCO2/ARPC1B/GSK3A/RPS6KB2/MTOR/UBC/RHOA/PRKCQ/MAPK14/PRKCD/IL1R1/ITPR3/RBCK1/ARPC2/CHUK/IRF3/CYCS/CSF2/CAPN1/RPS27A/NFKBIB/CXCL8/CD44/CYTH1/CUL1/AKT2/TRADD/ARHGEF2/PIK3R2/WIPI2/GLMN/ACTN4/TRAF6/ARPC1A/PIK3CB/FOXO3/MAPK10/ROCK2/RAC1/RRAGA/U2AF1/MAPK13/MYL12B	79
KEGG	hsa05160	Hepatitis C	56/1542	157/8135	4.813e-07	9.37e-06	4.857e-06	TNFRSF1A/OAS2/TYK2/YWHAQ/CDKN1A/MAPK3/TP53/AKT1/PPP2R1A/IFNAR1/PPP2R2A/PIK3CD/CASP3/IFNAR2/PSME3/IFNG/STAT2/MAP2K2/RXRA/SCARB1/HRAS/KRAS/RSAD2/IKBKB/ARAF/FAS/SOS1/BAK1/IFNA2/CFLAR/CDK2/GRB2/CDK4/BAD/MX2/CCND1/RB1/CHUK/IRF3/CYCS/CTNNB1/IFIT1/MAP2K1/STAT1/FADD/IKBKE/AKT2/FASLG/TRADD/PIK3R2/TRAF6/PIK3CB/YWHAH/MX1/YWHAB/PPARA	56
KEGG	hsa05203	Viral carcinogenesis	68/1542	204/8135	5.56e-07	1.023e-05	5.3e-06	CCND2/DDB1/HDAC6/JUN/ATF4/CCNA1/YWHAQ/CDKN1A/RBPJ/MAPK3/CREBBP/CREB1/MRPS18B/GTF2B/DDX3X/TP53/LTBR/PIK3CD/CASP3/RBL2/SND1/REL/PMAIP1/HDAC1/HRAS/SYK/KRAS/GTF2H2/CDC42/NFKB2/RHOA/CCR5/BAK1/SCRIB/EGR2/SRF/CDK2/GRB2/GTF2H4/CDK4/SNW1/BAD/CCND1/RB1/CHEK1/IRF3/PRKACB/KAT2A/CDKN2A/KAT2B/PSMC1/GTF2E2/TRADD/PIK3R2/ACTN4/TBPL1/CCNA2/PIK3CB/TRAF1/HLA-A/YWHAH/CCR4/YWHAB/CDK1/RAC1/ATP6V0D1/STAT5A/HNRNPK	68
KEGG	hsa05161	Hepatitis B	57/1542	162/8135	6.394e-07	1.114e-05	5.774e-06	DDB1/JUN/ATF4/CCNA1/TYK2/YWHAQ/CDKN1A/MAPK3/CREBBP/CREB1/DDX3X/TP53/AKT1/IFNAR1/PIK3CD/CASP3/MMP9/STAT2/MAP2K2/STAT6/HRAS/KRAS/IKBKB/ARAF/FAS/ATP6AP1/SOS1/PCNA/EGR2/MAPK14/IFNA2/CDK2/GRB2/BAD/RB1/CHUK/IRF3/CYCS/CASP10/IRAK1/MAP2K1/STAT1/CXCL8/TGFB2/FADD/IKBKE/AKT2/FASLG/PIK3R2/TRAF6/CCNA2/PIK3CB/YWHAB/MAP2K3/MAPK10/MAPK13/STAT5A	57
KEGG	hsa05132	Salmonella infection	79/1542	249/8135	6.788e-07	1.123e-05	5.823e-06	RAB5C/S100A10/RHOG/TNFRSF1A/JUN/TUBB2A/MAPK3/TXN/ARF6/AKT1/PKN1/TXN2/PFN1/DYNC1LI2/TUBB/VPS11/PIK3CD/CASP4/CASP3/KIF5B/NAIP/TLR5/FLNB/CD14/CYFIP1/MAP2K2/ELMO1/BIRC3/RHOH/HSP90AB1/NLRP3/ACBD3/HRAS/PFN2/RALA/CDC42/VPS39/IKBKB/DCTN3/KIF5C/ARPC1B/ACTR1B/RHOA/BAK1/HSP90AA1/NCKAP1L/MAPK14/RRAS/ARPC2/CHUK/CYCS/CYFIP2/CASP7/LY96/TNFSF10/CTNNB1/IRAK1/MAP2K1/CXCL8/PLEKHM2/TUBB2B/CYTH1/STX10/DYNC1H1/KPNA3/FADD/AKT2/DNM2/TRADD/TRAF6/ARPC1A/MYO6/PIK3CB/MAP2K3/MAPK10/ROCK2/RAC1/MAPK13/MYL12B	79
KEGG	hsa04660	T cell receptor signaling pathway	41/1542	104/8135	8.55e-07	1.348e-05	6.985e-06	CD4/VAV1/JUN/MAPK3/FYN/AKT1/PIK3CD/CD3D/IFNG/MAP2K2/MAP3K14/HRAS/MALT1/KRAS/CDC42/IKBKB/SOS1/CD3G/RHOA/PRKCQ/MAPK14/GRB2/PPP3CC/CDK4/MAP3K8/CHUK/CSF2/MAP2K1/NFKBIB/ICOS/CD28/AKT2/LCK/CD247/PIK3R2/ITK/PIK3CB/MAPK10/LCP2/RASGRP1/MAPK13	41
KEGG	hsa05162	Measles	50/1542	139/8135	1.475e-06	2.219e-05	1.15e-05	CCND2/OAS2/JUN/TYK2/TP53/AKT1/IFNAR1/IL2RG/HSPA6/PIK3CD/CASP3/HSPA8/IFNAR2/CD3D/TNFAIP3/STAT2/SLAMF1/IKBKB/FAS/CD3G/BAK1/IL2RB/IFNA2/ADAR/CDK2/CDK4/BAD/MX2/CCND1/CHUK/IRF3/CYCS/IRAK1/HSPA1B/STAT1/NFKBIB/CD28/FADD/IKBKE/AKT2/FASLG/TRADD/CSNK2A1/EIF3H/PIK3R2/TRAF6/PIK3CB/MX1/MAPK10/STAT5A	50
KEGG	hsa05223	Non-small cell lung cancer	31/1542	72/8135	2.06e-06	2.965e-05	1.537e-05	CDKN1A/MAPK3/TP53/AKT1/PIK3CD/KIF5B/GADD45A/MAP2K2/RXRA/HRAS/KRAS/ARAF/KIF5C/SOS1/BAK1/HGF/GRB2/CDK4/GADD45B/BAD/CCND1/RB1/MAP2K1/CDKN2A/AKT2/RXRB/PIK3R2/PIK3CB/FOXO3/MET/STAT5A	31
KEGG	hsa04218	Cellular senescence	54/1542	156/8135	2.236e-06	2.997e-05	1.553e-05	CCND2/ATM/TSC2/CCNA1/RHEB/CDKN1A/MAPK3/ITPR2/TP53/AKT1/TRAF3IP2/HIPK1/PIK3CD/SLC25A6/ZFP36L2/RBL2/GADD45A/MAP2K2/E2F4/HRAS/CAPN2/KRAS/MTOR/RBBP4/MAPK14/RRAS/CDK2/ITPR3/PPP3CC/CDK4/GADD45B/RAD9A/CCND1/RB1/CHEK1/CAPN1/MAP2K1/CXCL8/KIR2DL4/CDKN2A/TGFB2/AKT2/LIN37/PIK3R2/PPP1CB/CCNA2/PIK3CB/FOXO3/HLA-A/MAP2K3/ATR/CCNB1/CDK1/MAPK13	54
KEGG	hsa05210	Colorectal cancer	35/1542	86/8135	2.264e-06	2.997e-05	1.553e-05	JUN/CDKN1A/MAPK3/TP53/AKT1/PIK3CD/CASP3/GADD45A/MAP2K2/PMAIP1/HRAS/KRAS/RALA/ARAF/AREG/SOS1/RPS6KB2/MTOR/RHOA/BAK1/EREG/GRB2/GADD45B/BAD/CCND1/CYCS/CTNNB1/MAP2K1/TGFB2/AKT2/PIK3R2/MSH2/PIK3CB/MAPK10/RAC1	35
KEGG	hsa04062	Chemokine signaling pathway	63/1542	192/8135	2.642e-06	3.299e-05	1.71e-05	VAV1/HCK/GNAI2/ARRB2/CXCL9/MAPK3/ADCY3/GNG7/RAP1B/GNG5/AKT1/PLCB3/ROCK1/WAS/PIK3CD/STAT2/DOCK2/CCL7/CCR7/PLCB2/ELMO1/HRAS/PTK2/KRAS/CCL20/CDC42/PPBP/GNB2/IKBKB/SOS1/GSK3A/FGR/RHOA/CCR5/GNG12/PRKCD/GNAI1/GRB2/ADCY9/BAD/CHUK/MAP2K1/STAT1/NFKBIB/PRKACB/CCR6/CXCL8/AKT2/CXCR6/CCL2/CCL16/PIK3R2/ITK/PIK3CB/FOXO3/CCR4/CXCL13/XCL1/CXCL12/CCL3/ROCK2/RAC1/SHC2	63
KEGG	hsa04722	Neurotrophin signaling pathway	44/1542	119/8135	2.691e-06	3.299e-05	1.71e-05	ARHGDIA/RPS6KA2/JUN/ATF4/MAPK3/RAP1B/TP53/PSEN2/AKT1/PIK3CD/ABL1/MAP2K2/RAPGEF1/HRAS/KRAS/CDC42/IKBKB/SOS1/IRS1/RHOA/SH2B1/MAPK14/PRKCD/MAGED1/GRB2/BAD/IRAK1/MAP2K1/NFKBIB/AKT2/MAPK7/FASLG/PIK3R2/CAMK2G/RPS6KA3/TRAF6/SORT1/PIK3CB/FOXO3/ARHGDIB/MAPK10/RAC1/MAPK13/SHC2	44
KEGG	hsa04668	TNF signaling pathway	42/1542	112/8135	2.965e-06	3.505e-05	1.817e-05	TNFRSF1A/JUN/ATF4/MAPK3/CREB1/AKT1/PIK3CD/CASP3/RPS6KA4/TNFAIP3/MMP9/ITCH/MAP3K14/BIRC3/MMP14/IL15/PTGS2/CCL20/IKBKB/FAS/CEBPB/MAPK14/CFLAR/IRF1/MAP3K8/CHUK/CSF2/CASP7/CASP10/MAP2K1/FADD/AKT2/CCL2/TRADD/PIK3R2/PIK3CB/TRAF1/MAP2K3/MAPK10/CSF1/MMP3/MAPK13	42
KEGG	hsa05205	Proteoglycans in cancer	66/1542	205/8135	3.214e-06	3.668e-05	1.901e-05	IGF1/EZR/VAV1/HCLS1/CD63/CDKN1A/MAPK3/ITPR2/TP53/AKT1/ROCK1/VEGFA/ITGB1/ITGB5/PIK3CD/CASP3/FZD2/FLNB/CAV1/MMP9/FN1/MAP2K2/THBS1/HRAS/PTK2/KRAS/CDC42/ARAF/FAS/SOS1/RPS6KB2/MTOR/RHOA/HGF/FZD7/MAPK14/PLAUR/RRAS/GRB2/ITPR3/CCND1/RDX/CTNNB1/MAP2K1/EIF4B/PRKACB/ERBB4/CD44/TGFB2/AKT2/FASLG/FGFR1/PIK3R2/PPP1CB/CAMK2G/GPC1/FZD5/PIK3CB/FZD6/CTSL/MET/ROCK2/LUM/RAC1/MAPK13/PPP1R12A	66
KEGG	hsa01522	Endocrine resistance	38/1542	98/8135	3.435e-06	3.789e-05	1.964e-05	IGF1/JUN/CDKN1A/MAPK3/ADCY3/TP53/AKT1/PIK3CD/NOTCH3/MMP9/MAP2K2/NOTCH2/MED1/HRAS/PTK2/KRAS/ARAF/SOS1/GNAS/RPS6KB2/MTOR/MAPK14/GRB2/CDK4/ADCY9/BAD/CCND1/RB1/MAP2K1/PRKACB/CDKN2A/AKT2/CARM1/PIK3R2/PIK3CB/MAPK10/MAPK13/SHC2	38
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	63/1542	194/8135	3.896e-06	4.16e-05	2.156e-05	HCK/TNFRSF1A/JUN/MAP1LC3B/TYK2/CDKN1A/MAPK3/CREBBP/ITPR2/CREB1/GNG7/TP53/GNG5/AKT1/RCAN1/IFNAR1/VEGFA/CLEC2B/PIK3CD/CASP3/IFNAR2/STAT2/MAP2K2/HRAS/SYK/PTGS2/KRAS/GNB2/IKBKB/FAS/MTOR/UBC/CCR5/BAK1/PDGFB/GNG12/MAPK14/IFNA2/ITPR3/PPP3CC/CDK4/CCND1/RB1/CHUK/IRF3/CYCS/CSF2/CTNNB1/MAP2K1/RPS27A/STAT1/CXCL8/FADD/IKBKE/AKT2/TRADD/PIK3R2/PIK3CB/HLA-A/CCR4/MAPK10/RAC1/MAPK13	63
KEGG	hsa04151	PI3K-Akt signaling pathway	101/1542	354/8135	5.067e-06	5.241e-05	2.717e-05	CCND2/SPP1/IGF1/FLT1/CSF1R/TSC2/ITGB7/ATF4/RHEB/VEGFB/YWHAQ/CDKN1A/MAPK3/CREB1/GNG7/TP53/MCL1/GNG5/AKT1/PPP2R1A/PKN1/IFNAR1/LAMB2/IL2RG/VEGFA/PPP2R2A/ITGB1/ITGB5/PIK3CD/DDIT4/PHLPP1/IFNAR2/OSMR/RBL2/FN1/MAP2K2/RXRA/IL3RA/ITGA7/HSP90AB1/COL4A1/LAMC1/THBS1/HRAS/PTK2/SYK/PHLPP2/KRAS/GNB2/MYB/IKBKB/AREG/SOS1/RPS6KB2/IRS1/MTOR/HSP90AA1/PDGFB/IL2RB/GNG12/HGF/IFNA2/EREG/ITGA1/CDK2/CSF3R/GRB2/GHR/CDK4/FGF9/PDGFA/STK11/BAD/CCND1/FGF1/CHUK/MAP2K1/EIF4B/PRKAA1/EIF4E/ERBB4/AKT2/PPP2R5D/NR4A1/FASLG/FGFR1/PIK3R2/LAMA2/PIK3CB/FOXO3/ITGB8/FGF7/YWHAH/YWHAB/MAGI1/GH1/MET/RAC1/CSF1/F2R/COL4A4	101
KEGG	hsa05218	Melanoma	30/1542	72/8135	6.745e-06	6.765e-05	3.507e-05	IGF1/CDKN1A/MAPK3/TP53/AKT1/PIK3CD/GADD45A/MAP2K2/HRAS/KRAS/ARAF/BAK1/PDGFB/HGF/CDK4/FGF9/PDGFA/GADD45B/BAD/CCND1/RB1/FGF1/MAP2K1/CDKN2A/AKT2/FGFR1/PIK3R2/PIK3CB/FGF7/MET	30
KEGG	hsa05145	Toxoplasmosis	41/1542	112/8135	7.793e-06	7.385e-05	3.828e-05	HLA-DMB/TNFRSF1A/GNAI2/TYK2/MAPK3/AKT1/HLA-DMA/IL10RA/LAMB2/HSPA6/ITGB1/CASP3/HSPA8/IFNG/BIRC3/LAMC1/PPIF/IKBKB/HLA-DOB/CCR5/MAPK14/GNAI1/ALOX5/BAD/CHUK/CYCS/CIITA/LY96/IRAK1/HSPA1B/STAT1/NFKBIB/HLA-DQB1/TGFB2/AKT2/LAMA2/TRAF6/MAP2K3/MAPK10/GNAO1/MAPK13	41
KEGG	hsa05211	Renal cell carcinoma	29/1542	69/8135	7.809e-06	7.385e-05	3.828e-05	JUN/CDKN1A/MAPK3/CREBBP/RAP1B/AKT1/TFE3/VEGFA/PIK3CD/ARNT/MAP2K2/RAPGEF1/HRAS/KRAS/CDC42/ARAF/SOS1/PDGFB/HGF/GRB2/BAD/MAP2K1/TGFB2/AKT2/PIK3R2/CUL2/PIK3CB/MET/RAC1	29
KEGG	hsa05220	Chronic myeloid leukemia	31/1542	76/8135	8.049e-06	7.401e-05	3.836e-05	CDKN1A/MAPK3/TP53/AKT1/PIK3CD/ABL1/GADD45A/MAP2K2/HDAC1/HRAS/KRAS/IKBKB/ARAF/SOS1/BAK1/CTBP1/GRB2/CDK4/GADD45B/BAD/CCND1/RB1/CHUK/MAP2K1/CDKN2A/TGFB2/AKT2/PIK3R2/PIK3CB/SHC2/STAT5A	31
KEGG	hsa04611	Platelet activation	44/1542	124/8135	9.323e-06	8.34e-05	4.323e-05	TBXAS1/PTGIR/GNAI2/BTK/MAPK3/ITPR2/ADCY3/RAP1B/FYN/AKT1/PLCB3/ROCK1/ITGB1/PIK3CD/PLCB2/SYK/TLN1/SNAP23/P2RX1/GNAS/RHOA/MYLK/ARHGAP35/MAPK14/PRKCI/GNAI1/ITPR3/ADCY9/STIM1/VAMP8/PRKACB/FGG/AKT2/PIK3R2/PPP1CB/PIK3CB/ROCK2/LCP2/PLA2G4A/RASGRP1/MAPK13/PPP1R12A/F2R/MYL12B	44
KEGG	hsa04919	Thyroid hormone signaling pathway	43/1542	121/8135	1.125e-05	9.797e-05	5.078e-05	TSC2/RHEB/MAPK3/CREBBP/TP53/PFKP/AKT1/PLCB3/RCAN1/ATP1A1/MED24/MED13/PIK3CD/NOTCH3/ATP1B3/PFKL/ATP2A3/MAP2K2/RXRA/NOTCH2/PLCB2/MED1/HDAC1/HRAS/KRAS/PLN/MTOR/PFKM/PFKFB2/BAD/CCND1/CTNNB1/MAP2K1/STAT1/MED13L/PRKACB/KAT2A/KAT2B/AKT2/RXRB/PIK3R2/PIK3CB/DIO2	43
KEGG	hsa04910	Insulin signaling pathway	47/1542	137/8135	1.316e-05	0.0001117	5.789e-05	FBP1/TSC2/PYGL/RHEB/HK2/MAPK3/FASN/INPPL1/AKT1/MKNK1/PIK3CD/PHKB/PYGB/RHOQ/MAP2K2/RAPGEF1/HRAS/KRAS/IKBKB/ARAF/SOS1/RPS6KB2/IRS1/MTOR/PRKCI/FLOT2/GRB2/PHKG2/BAD/SREBF1/MAP2K1/PRKAA1/PRKACB/MKNK2/TRIP10/EIF4E/PHKA2/AKT2/SLC2A4/PIK3R2/PPP1CB/PRKAR2B/PRKAG1/PIK3CB/PRKAR2A/MAPK10/SHC2	47
KEGG	hsa04068	FoxO signaling pathway	45/1542	131/8135	1.925e-05	0.0001569	8.135e-05	CCND2/IGF1/ATM/GABARAP/CDKN1A/ATG12/MAPK3/CREBBP/CAT/AKT1/PIK3CD/GABARAPL1/RBL2/GADD45A/MAP2K2/HRAS/KRAS/IKBKB/ARAF/SOS1/IRS1/HOMER3/MAPK14/CDK2/GRB2/GADD45B/STK11/CCND1/CHUK/TNFSF10/MAP2K1/PRKAA1/TGFB2/HOMER1/AKT2/FASLG/GABARAPL2/SLC2A4/PIK3R2/PRKAG1/PIK3CB/FOXO3/MAPK10/CCNB1/MAPK13	45
KEGG	hsa05215	Prostate cancer	36/1542	97/8135	1.944e-05	0.0001569	8.135e-05	IGF1/GSTP1/ATF4/CDKN1A/MAPK3/CREBBP/CREB1/TP53/IL1R2/AKT1/PIK3CD/MMP9/MAP2K2/HSP90AB1/HRAS/KRAS/IKBKB/ARAF/SOS1/MTOR/HSP90AA1/PDGFB/CDK2/GRB2/PDGFA/BAD/CCND1/RB1/CHUK/CTNNB1/MAP2K1/AKT2/FGFR1/PIK3R2/PIK3CB/MMP3	36
KEGG	hsa05164	Influenza A	55/1542	171/8135	2.161e-05	0.0001703	8.827e-05	HLA-DMB/TNFRSF1A/OAS2/RAB11B/DNAJB1/TYK2/MAPK3/CREBBP/AKT1/HLA-DMA/IFNAR1/HNRNPUL1/PIK3CD/CASP3/SLC25A6/IFNAR2/IFNG/STAT2/MAP2K2/NLRP3/PML/RSAD2/IKBKB/FAS/CALCOCO2/HLA-DOB/CPSF4/KPNA2/BAK1/IFNA2/ADAR/CDK4/MX2/FDPS/CHUK/IRF3/CYCS/CIITA/TNFSF10/MAP2K1/STAT1/NFKBIB/HLA-DQB1/RAE1/CXCL8/NXF1/FADD/IKBKE/AKT2/FASLG/CCL2/TRADD/PIK3R2/PIK3CB/MX1	55
KEGG	hsa01524	Platinum drug resistance	29/1542	73/8135	2.847e-05	0.0002192	0.0001136	GSTP1/ATM/CDKN1A/MAPK3/TP53/AKT1/XPA/PIK3CD/CASP3/PMAIP1/BIRC3/MGST2/FAS/REV3L/GSTO1/BAK1/TOP2B/ATP7A/BAD/CYCS/ERCC1/CDKN2A/FADD/AKT2/FASLG/PIK3R2/MSH2/PIK3CB/ATP7B	29
KEGG	hsa04015	Rap1 signaling pathway	64/1542	210/8135	3.217e-05	0.000242	0.0001254	IGF1/FLT1/CSF1R/VAV1/GNAI2/ADORA2B/VEGFB/MAPK3/SIPA1/RAPGEF2/ADCY3/RAP1B/ITGAM/AKT1/PLCB3/PFN1/VEGFA/ITGB1/ID1/PIK3CD/MAP2K2/PLCB2/RAPGEF1/THBS1/HRAS/PFN2/KRAS/TLN1/RALA/SIPA1L3/CDC42/PRKD2/GNAS/RHOA/ITGB2/PDGFB/HGF/MAPK14/RRAS/PRKCI/GNAI1/FGF9/PDGFA/ADCY9/FGF1/CTNNB1/MAP2K1/AKT2/FGFR1/PIK3R2/PRKD1/PIK3CB/FGF7/MAP2K3/MAGI1/MET/LCP2/ITGAL/RAC1/CSF1/GNAO1/MAPK13/F2R/PRKD3	64
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	28/1542	70/8135	3.358e-05	0.000247	0.000128	JUN/ATP6V0A1/ATP6V0C/TCIRG1/CASP3/MAP3K14/ATP6V1A/CSK/CDC42/IKBKB/ADAM10/ATP6AP1/ATP6V1B2/MAPK14/ATP6V1G1/CHUK/ATP6V1H/ATP6V1D/ATP6V1E1/CXCL8/ATP6V0E2/MAPK10/MET/RAC1/PTPRZ1/MAPK13/ADAM17/ATP6V0D1	28
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	33/1542	89/8135	4.365e-05	0.0003141	0.0001628	CD4/JUN/MAPK3/AKT1/PIK3CD/CD3D/IFNG/MAP2K2/HRAS/KRAS/IKBKB/RPS6KB2/MTOR/CD3G/PRKCQ/MAPK14/BATF/PPP3CC/CHUK/MAP2K1/STAT1/NFKBIB/CD28/AKT2/LCK/CD247/CSNK2A1/PIK3R2/TRAF6/PIK3CB/MAP2K3/RASGRP1/MAPK13	33
KEGG	hsa03420	Nucleotide excision repair	21/1542	47/8135	4.669e-05	0.0003288	0.0001704	DDB1/CUL4B/RPA1/RFC5/XPA/GTF2H2/CDK7/ERCC4/PCNA/CUL4A/RFC2/GTF2H4/XPC/CCNH/POLD1/RAD23B/POLD4/ERCC1/LIG1/RAD23A/GTF2H5	21
KEGG	hsa05214	Glioma	29/1542	75/8135	5.15e-05	0.000355	0.000184	IGF1/CAMK1/CDKN1A/MAPK3/TP53/AKT1/PIK3CD/GADD45A/MAP2K2/HRAS/KRAS/ARAF/SOS1/MTOR/BAK1/PDGFB/GRB2/CDK4/PDGFA/GADD45B/CCND1/RB1/MAP2K1/CDKN2A/AKT2/PIK3R2/CAMK2G/PIK3CB/SHC2	29
KEGG	hsa05152	Tuberculosis	56/1542	180/8135	5.256e-05	0.000355	0.000184	CEBPG/RAB5C/HLA-DMB/TNFRSF1A/LSP1/ATP6V0A1/MAPK3/CREBBP/CREB1/ATP6V0C/ITGAM/AKT1/HLA-DMA/IL10RA/FCGR3A/TCIRG1/CASP3/CD14/IFNG/SPHK2/SYK/MALT1/MRC1/CTSD/ATP6AP1/HLA-DOB/CEBPB/RHOA/ITGB2/HSPA9/MAPK14/IFNA2/MRC2/PPP3CC/BAD/CYCS/CIITA/CASP10/ATP6V1H/IRAK1/STAT1/HLA-DQB1/TGFB2/CORO1A/FADD/AKT2/RFX5/TRADD/CAMK2G/TRAF6/HSPD1/MAPK10/TLR1/MAPK13/CYP27B1/ATP6V0D1	56
KEGG	hsa04664	Fc epsilon RI signaling pathway	27/1542	68/8135	5.387e-05	0.0003566	0.0001849	VAV1/BTK/MAPK3/FYN/AKT1/PIK3CD/INPP5D/MAP2K2/HRAS/SYK/KRAS/SOS1/MAPK14/GRB2/ALOX5/CSF2/MAP2K1/ALOX5AP/AKT2/PIK3R2/PIK3CB/MAP2K3/MAPK10/LCP2/RAC1/PLA2G4A/MAPK13	27
KEGG	hsa04150	mTOR signaling pathway	50/1542	156/8135	5.59e-05	0.0003628	0.0001881	IGF1/RPS6KA2/TNFRSF1A/TSC2/RHEB/MAPK3/AKT1/PIK3CD/RRAGD/DDIT4/FZD2/MAP2K2/ATP6V1A/HRAS/KRAS/IKBKB/SOS1/RPS6KB2/IRS1/MTOR/RHOA/MAPKAP1/ATP6V1B2/FZD7/ATP6V1G1/GRB2/STK11/TTI1/CHUK/ATP6V1H/MAP2K1/EIF4B/ULK2/PRKAA1/ATP6V1D/ATP6V1E1/GRB10/EIF4E/AKT2/DVL3/PIK3R2/RPS6KA3/CLIP1/NPRL3/FZD5/PIK3CB/SLC7A5/FZD6/RRAGA/LRP6	50
KEGG	hsa05130	Pathogenic Escherichia coli infection	60/1542	197/8135	5.747e-05	0.0003658	0.0001896	EZR/TNFRSF1A/RAB1A/JUN/HCLS1/MYO1F/TUBB2A/MAPK3/ARF6/FYN/ARHGEF11/ROCK1/TUBB/ITGB1/CASP4/ABL1/CASP3/NAIP/TLR5/CYFIP1/NLRP3/SEC24C/CDC42/IKBKB/FAS/ARPC1B/RHOA/BAK1/NCKAP1L/MAPK14/MYO5A/IL1R1/ARPC2/GNA12/CHUK/CYCS/CYFIP2/CASP7/TNFSF10/IRAK1/NFKBIB/CXCL8/TUBB2B/CYTH1/SEC24B/FADD/FASLG/TRADD/MYO1E/MYH9/ARHGEF2/SEC24A/TRAF6/ARPC1A/MYO6/MAPK10/ROCK2/RAC1/MAPK13/F2R	60
KEGG	hsa05135	Yersinia infection	45/1542	137/8135	6.736e-05	0.000413	0.0002141	CD4/VAV1/PIP5K1C/RHOG/RPS6KA2/JUN/MAPK3/ARF6/AKT1/PKN1/ROCK1/ITGB1/WAS/PIK3CD/FN1/MAP2K2/ELMO1/NLRP3/PTK2/CDC42/IKBKB/ARPC1B/RHOA/MAPK14/PIP5K1A/ARPC2/CHUK/IRF3/IRAK1/MAP2K1/CXCL8/AKT2/LCK/CCL2/PIK3R2/RPS6KA3/TRAF6/ARPC1A/PIK3CB/MAP2K3/MAPK10/ROCK2/LCP2/RAC1/MAPK13	45
KEGG	hsa05142	Chagas disease	36/1542	102/8135	6.738e-05	0.000413	0.0002141	TNFRSF1A/GNAI2/JUN/MAPK3/AKT1/PPP2R1A/PLCB3/PPP2R2A/PIK3CD/CD3D/IFNG/PLCB2/ACE/IKBKB/FAS/GNAS/CD3G/MAPK14/CFLAR/GNAI1/CHUK/IRAK1/CXCL8/TGFB2/FADD/AKT2/FASLG/CCL2/CD247/PIK3R2/TRAF6/PIK3CB/CCL3/MAPK10/GNAO1/MAPK13	36
KEGG	hsa05222	Small cell lung cancer	33/1542	92/8135	9.33e-05	0.0005615	0.0002911	CKS2/CDKN1A/TP53/AKT1/LAMB2/ITGB1/PIK3CD/CASP3/GADD45A/FN1/RXRA/BIRC3/COL4A1/LAMC1/PTK2/PTGS2/IKBKB/BAK1/CDK2/CDK4/GADD45B/CCND1/RB1/CHUK/CYCS/AKT2/RXRB/PIK3R2/LAMA2/TRAF6/PIK3CB/TRAF1/COL4A4	33
KEGG	hsa05230	Central carbon metabolism in cancer	27/1542	70/8135	9.731e-05	0.0005671	0.000294	LDHA/IDH2/HK2/PGAM1/MAPK3/TP53/PFKP/AKT1/PIK3CD/PFKL/MAP2K2/HRAS/KRAS/GLS/MTOR/PFKM/IDH1/MAP2K1/AKT2/FGFR1/PIK3R2/PDHB/PIK3CB/SLC7A5/MET/LDHC/SLC2A2	27
KEGG	hsa05017	Spinocerebellar ataxia	46/1542	143/8135	9.926e-05	0.0005671	0.000294	RBPJ/ITPR2/GTF2B/AKT1/PLCB3/RB1CC1/PSMB4/PIK3CD/SLC25A6/ATP2A3/PLCB2/PSMB3/PSMD3/PPIF/PSMD11/PSMA1/VLDLR/XBP1/MTOR/ATXN3/ITPR3/PSMD14/ATXN10/CYCS/ATXN2L/ULK2/PSMC6/CIC/PSMA3/PSMC1/AKT2/ADRM1/PIK3R2/WIPI2/PSMB1/TBPL1/ATG2A/BEAN1/PSMA4/PIK3CB/RORA/PSMC4/MAPK10/KAT5/PSMD13/PSMD8	46
KEGG	hsa05418	Fluid shear stress and atherosclerosis	45/1542	139/8135	9.938e-05	0.0005671	0.000294	GSTP1/TNFRSF1A/JUN/TXN/TP53/IL1R2/AKT1/TXN2/VEGFA/PIK3CD/CAV1/IFNG/MMP9/HSP90AB1/PTK2/PECAM1/MGST2/ACVR1/IKBKB/GSTO1/SUMO1/RHOA/HSP90AA1/PDGFB/MAPK14/HMOX1/IL1R1/PDGFA/CHUK/CTNNB1/MEF2A/PRKAA1/AKT2/MAPK7/CCL2/ARHGEF2/PIK3R2/GPC1/PIK3CB/SUMO3/CTSL/MAPK10/NFE2L2/RAC1/MAPK13	45
KEGG	hsa04064	NF-kappa B signaling pathway	36/1542	104/8135	0.0001067	0.0005886	0.0003051	BCL2A1/ATM/TNFRSF1A/BTK/LTBR/TNFSF14/CD14/TNFAIP3/GADD45A/MAP3K14/BIRC3/SYK/PTGS2/MALT1/IKBKB/NFKB2/PRKCQ/CFLAR/IL1R1/BLNK/GADD45B/TNFSF11/CHUK/PARP1/RELB/LY96/IRAK1/CXCL8/LCK/TRADD/CSNK2A1/TRAF6/ERC1/TRAF1/CXCL12/TNFRSF11A	36
KEGG	hsa04620	Toll-like receptor signaling pathway	36/1542	104/8135	0.0001067	0.0005886	0.0003051	SPP1/JUN/CXCL9/MAPK3/AKT1/IFNAR1/CTSK/PIK3CD/CD80/IFNAR2/TLR5/CD14/MAP2K2/IKBKB/MAPK14/IFNA2/MAP3K8/CHUK/IRF3/LY96/IRAK1/MAP2K1/STAT1/CXCL8/FADD/IKBKE/AKT2/PIK3R2/TRAF6/PIK3CB/MAP2K3/CCL3/MAPK10/TLR1/RAC1/MAPK13	36
KEGG	hsa04810	Regulation of actin cytoskeleton	64/1542	218/8135	0.0001111	0.0006029	0.0003125	EZR/DIAPH1/VAV1/ARHGEF6/PIP5K1C/ITGB7/MAPK3/ITGAM/CFL1/ROCK1/PFN1/ITGB1/ITGB5/PIK3CD/CYFIP1/FN1/MAP2K2/IQGAP2/ITGA7/PIP4K2B/HRAS/PTK2/PFN2/KRAS/CDC42/PIP4K2A/ARAF/ARPC1B/SOS1/RHOA/ITGB2/MYLK/ARHGAP35/NCKAP1L/PDGFB/GNG12/PIP5K1A/RRAS/ITGA1/FGF9/PDGFA/FGF1/ARPC2/GNA12/RDX/CYFIP2/MAP2K1/MYH9/FGFR1/PIK3R2/PPP1CB/ACTN4/ARPC1A/PIK3CB/ITGB8/FGF7/CXCL12/ROCK2/ITGAL/RAC1/TMSB4X/PPP1R12A/F2R/MYL12B	64
KEGG	hsa04662	B cell receptor signaling pathway	30/1542	82/8135	0.0001272	0.0006792	0.0003521	VAV1/JUN/BTK/MAPK3/LILRB5/INPPL1/AKT1/PIK3CD/INPP5D/MAP2K2/HRAS/SYK/MALT1/KRAS/LILRA3/IKBKB/SOS1/GRB2/PPP3CC/LILRB4/BLNK/CHUK/MAP2K1/NFKBIB/CD22/AKT2/IFITM1/PIK3R2/PIK3CB/RAC1	30
KEGG	hsa04140	Autophagy - animal	45/1542	141/8135	0.0001446	0.00076	0.0003939	GABARAP/RAB1A/TSC2/MAP1LC3B/RHEB/ATG12/MAPK3/AKT1/RB1CC1/DAPK1/PIK3CD/RRAGD/DDIT4/GABARAPL1/MAP2K2/TANK/HRAS/KRAS/CTSD/RPS6KB2/IRS1/MTOR/PRKCQ/CFLAR/RRAS/PRKCD/STK11/BAD/MTMR4/VAMP8/MAP2K1/ULK2/PRKAA1/PRKACB/SH3GLB1/AKT2/GABARAPL2/PIK3R2/WIPI2/TRAF6/ATG2A/PIK3CB/CTSL/MAPK10/RRAGA	45
KEGG	hsa05216	Thyroid cancer	17/1542	37/8135	0.000161	0.0008326	0.0004316	CDKN1A/MAPK3/PPARG/TP53/NCOA4/GADD45A/MAP2K2/RXRA/HRAS/KRAS/BAK1/GADD45B/CCND1/CTNNB1/MAP2K1/TPR/RXRB	17
KEGG	hsa05213	Endometrial cancer	23/1542	58/8135	0.0001938	0.0009869	0.0005116	CDKN1A/ILK/MAPK3/TP53/AKT1/PIK3CD/GADD45A/MAP2K2/HRAS/KRAS/ARAF/SOS1/BAK1/GRB2/GADD45B/BAD/CCND1/CTNNB1/MAP2K1/AKT2/PIK3R2/PIK3CB/FOXO3	23
KEGG	hsa04932	Non-alcoholic fatty liver disease	48/1542	155/8135	0.000199	0.0009981	0.0005174	TNFRSF1A/JUN/ATF4/PPARG/CYC1/MAP3K11/AKT1/CEBPA/DDIT3/PIK3CD/CASP3/UQCRC1/NDUFV1/RXRA/ITCH/NDUFS2/ADIPOQ/CDC42/IKBKB/FAS/NDUFB1/XBP1/NDUFA2/ADIPOR2/GSK3A/IRS1/NDUFS7/MAPK14/COX5A/CYCS/SREBF1/CASP7/UQCR11/PRKAA1/CXCL8/COX7A2/AKT2/FASLG/PIK3R2/SDHC/PRKAG1/PIK3CB/PPARA/NDUFC1/MAPK10/RAC1/NDUFS3/MAPK13	48
KEGG	hsa05219	Bladder cancer	18/1542	41/8135	0.0002123	0.001049	0.0005437	CDKN1A/MAPK3/TP53/DAPK1/VEGFA/MMP9/MAP2K2/THBS1/HRAS/KRAS/ARAF/CDK4/CCND1/MMP1/RB1/MAP2K1/CXCL8/CDKN2A	18
KEGG	hsa05202	Transcriptional misregulation in cancer	57/1542	193/8135	0.000218	0.001061	0.0005501	CCND2/IGF1/FLT1/CSF1R/BCL2A1/ATM/ITGB7/CCNA1/NR4A3/CDKN1A/SPI1/PPARG/TP53/IL1R2/ITGAM/HHEX/TFE3/CEBPA/DDIT3/LYL1/CDK14/CCNT2/CD14/MMP9/REL/GADD45A/RXRA/LDB1/HPGD/TAF15/BIRC3/PER2/PML/HDAC1/PTK2/CEBPB/JMJD1C/BAK1/IL2RB/MLLT1/MLF1/PDGFA/GADD45B/LMO2/CSF2/CXCL8/RXRB/MEN1/ID2/JUP/DUSP6/CCNA2/TRAF1/MET/ELK4/GZMB/MMP3	57
KEGG	hsa05171	Coronavirus disease - COVID-19	66/1542	232/8135	0.00024	0.001136	0.0005886	RPS15A/F13A1/RPL36AL/TNFRSF1A/OAS2/JUN/TYK2/RPL24/MAPK3/RPL9/IFNAR1/RPS25/PIK3CD/RPL31/RPS19/IFNAR2/RPL7/STAT2/C5/NLRP3/FAU/ACE/RPS21/SYK/IKBKB/RPL6/RPS29/MAPK14/IFNA2/ADAR/RPL34/MX2/MMP1/CFD/CHUK/IRF3/CSF2/IRAK1/RPS27A/STAT1/NFKBIB/RPL13/CXCL8/FGG/RPS15/IKBKE/RPS7/CCL2/PIK3R2/C7/TRAF6/RPS16/RPL22/C8B/PIK3CB/RPL37/RPL38/MX1/RPL11/MAPK10/RPS4Y1/MMP3/MAPK13/C1R/ADAM17/RPL14	66
KEGG	hsa04145	Phagosome	47/1542	152/8135	0.0002401	0.001136	0.0005886	NCF4/RAB5C/HLA-DMB/TUBB2A/ATP6V0A1/ATP6V0C/MARCO/ITGAM/HLA-DMA/FCGR3A/DYNC1LI2/TUBB/ITGB1/ITGB5/TCIRG1/CD14/ATP6V1A/SCARB1/THBS1/HGS/TAP1/MRC1/ATP6AP1/HLA-DOB/SEC22B/ITGB2/ATP6V1B2/FCAR/MRC2/ATP6V1G1/OLR1/ATP6V1H/HLA-DQB1/ATP6V1D/ATP6V1E1/TUBB2B/DYNC1H1/CORO1A/SEC61G/CD36/ATP6V0E2/HLA-A/CTSL/RAC1/MSR1/C1R/ATP6V0D1	47
KEGG	hsa04659	Th17 cell differentiation	36/1542	108/8135	0.0002523	0.001176	0.0006098	CD4/HLA-DMB/JUN/TYK2/MAPK3/HLA-DMA/IL2RG/CD3D/IFNG/RXRA/IL1RAP/HSP90AB1/STAT6/IKBKB/HLA-DOB/MTOR/CD3G/PRKCQ/HSP90AA1/IL2RB/MAPK14/IL12RB1/IL1R1/PPP3CC/CHUK/STAT1/NFKBIB/HLA-DQB1/RXRB/LCK/CD247/RORA/IL27RA/MAPK10/MAPK13/STAT5A	36
KEGG	hsa04152	AMPK signaling pathway	39/1542	120/8135	0.0002581	0.001187	0.0006151	FBP1/IGF1/PFKFB3/RAB11B/TSC2/CCNA1/RHEB/CREB1/PPARG/SCD/FASN/PFKP/AKT1/PPP2R1A/PPP2R2A/PIK3CD/PFKL/EEF2/ADIPOQ/ADIPOR2/RPS6KB2/IRS1/MTOR/PFKM/PFKFB2/STK11/CCND1/SREBF1/PRKAA1/AKT2/PPP2R5D/SLC2A4/PIK3R2/CD36/CCNA2/PRKAG1/PIK3CB/FOXO3/RAB2A	39
KEGG	hsa04657	IL-17 signaling pathway	32/1542	94/8135	0.0003569	0.001618	0.0008388	S100A8/JUN/MAPK3/MAPK6/TRAF3IP2/CASP3/TNFAIP3/IFNG/MMP9/CCL7/HSP90AB1/ANAPC5/PTGS2/CCL20/IKBKB/CEBPB/HSP90AA1/MAPK14/MMP1/CHUK/CSF2/CXCL8/FADD/IKBKE/MAPK7/CCL2/S100A9/TRADD/TRAF6/MAPK10/MMP3/MAPK13	32
KEGG	hsa04914	Progesterone-mediated oocyte maturation	34/1542	102/8135	0.0003706	0.001644	0.0008524	IGF1/RPS6KA2/GNAI2/CCNA1/MAPK3/ADCY3/AKT1/ANAPC15/PIK3CD/HSP90AB1/ANAPC13/ANAPC5/MAD2L1/KRAS/ARAF/HSP90AA1/MAPK14/GNAI1/CDK2/ADCY9/CDC16/KIF22/MAP2K1/PRKACB/AKT2/PIK3R2/RPS6KA3/CCNA2/PIK3CB/CDC25B/MAPK10/CCNB1/CDK1/MAPK13	34
KEGG	hsa03050	Proteasome	19/1542	46/8135	0.0003726	0.001644	0.0008524	PSMB4/PSME3/IFNG/PSMB3/PSMD3/PSMB9/PSMD11/PSMA1/PSME1/PSMD14/PSMC6/PSMA3/PSMC1/ADRM1/PSMB1/PSMA4/PSMC4/PSMD13/PSMD8	19
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	28/1542	79/8135	0.0003886	0.001692	0.0008772	IGF1/MAPK3/AKT1/VEGFA/PIK3CD/MAP2K2/HRAS/KRAS/ARAF/SOS1/GAS6/RPS6KB2/MTOR/PDGFB/HGF/GRB2/AXL/PDGFA/BAD/MAP2K1/EIF4E/AKT2/PIK3R2/NF1/PIK3CB/FOXO3/MET/SHC2	28
KEGG	hsa05110	Vibrio cholerae infection	20/1542	50/8135	0.0004367	0.001877	0.0009731	ATP6V0A1/ATP6V0C/ADCY3/KDELR1/TCIRG1/ATP6V1A/KCNQ1/SLC12A2/ATP6AP1/GNAS/ATP6V1B2/ATP6V1G1/ADCY9/ATP6V1H/ATP6V1D/PRKACB/ATP6V1E1/SEC61G/ATP6V0E2/ATP6V0D1	20
KEGG	hsa04071	Sphingolipid signaling pathway	38/1542	119/8135	0.0004564	0.001912	0.0009913	ADORA3/TNFRSF1A/GNAI2/PLD2/MAPK3/SMPD1/TP53/FYN/AKT1/PPP2R1A/PLCB3/ROCK1/PPP2R2A/ASAH1/PIK3CD/ABCC1/NSMAF/MAP2K2/PLCB2/PLD1/HRAS/SPHK2/KRAS/CTSD/RHOA/MAPK14/GNAI1/GNA12/MAP2K1/AKT2/PPP2R5D/TRADD/PIK3R2/PIK3CB/MAPK10/ROCK2/RAC1/MAPK13	38
KEGG	hsa04935	Growth hormone synthesis, secretion and action	38/1542	119/8135	0.0004564	0.001912	0.0009913	IGF1/GNAI2/ATF4/MAPK3/CREBBP/ITPR2/CREB1/ADCY3/AKT1/PLCB3/PIK3CD/MAP2K2/PLCB2/HRAS/PTK2/KRAS/SOS1/GNAS/IRS1/MTOR/MAPK14/GNAI1/GRB2/ITPR3/GHR/ADCY9/MAP2K1/STAT1/PRKACB/AKT2/PIK3R2/PIK3CB/MAP2K3/GH1/MAPK10/MAPK13/SHC2/STAT5A	38
KEGG	hsa04072	Phospholipase D signaling pathway	45/1542	148/8135	0.0004871	0.002015	0.001045	PIP5K1C/DGKZ/TSC2/PLD2/RHEB/MAPK3/ARF6/ADCY3/FYN/AGPAT1/AKT1/PLCB3/PIK3CD/MAP2K2/PLCB2/PLD1/HRAS/SPHK2/SYK/KRAS/RALA/SOS1/GNAS/MTOR/RHOA/PDGFB/PIP5K1A/RRAS/GRB2/PDGFA/ADCY9/GNA12/MAP2K1/CXCL8/DGKD/CYTH1/AKT2/DNM2/PIK3R2/DNM1/DGKQ/PIK3CB/PLA2G4A/F2R/SHC2	45
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1542	100/8135	0.0005509	0.002251	0.001167	DIAPH1/JUN/VEGFB/MAPK3/PIM1/AKT1/PLCB3/VEGFA/PIK3CD/CASP3/FN1/PLCB2/COL4A1/HRAS/KRAS/CDC42/F3/MAPK14/PRKCD/CDK4/CCND1/STAT1/CXCL8/TGFB2/AKT2/CCL2/PIK3R2/PIK3CB/MAPK10/RAC1/MAPK13/COL4A4/STAT5A	33
KEGG	hsa04213	Longevity regulating pathway - multiple species	23/1542	62/8135	0.0006037	0.002437	0.001263	IGF1/CAT/ADCY3/AKT1/HSPA6/PIK3CD/HSPA8/HDAC1/HRAS/KRAS/RPS6KB2/IRS1/MTOR/ADCY9/HSPA1B/PRKAA1/PRKACB/FOXA2/AKT2/PIK3R2/PRKAG1/PIK3CB/FOXO3	23
KEGG	hsa04211	Longevity regulating pathway	30/1542	89/8135	0.0006503	0.002593	0.001344	IGF1/TSC2/ATF4/RHEB/CREB1/CAT/PPARG/ADCY3/TP53/AKT1/RB1CC1/PIK3CD/EHMT2/ADIPOQ/HRAS/KRAS/ADIPOR2/RPS6KB2/IRS1/MTOR/ADCY9/STK11/PRKAA1/PRKACB/EIF4E/AKT2/PIK3R2/PRKAG1/PIK3CB/FOXO3	30
KEGG	hsa04912	GnRH signaling pathway	31/1542	93/8135	0.0006609	0.002604	0.00135	JUN/ATF4/PLD2/MAPK3/ITPR2/ADCY3/PLCB3/MAP2K2/PLCB2/MMP14/PLD1/HRAS/KRAS/CDC42/SOS1/GNAS/MAPK14/PRKCD/GRB2/FSHB/ITPR3/ADCY9/MAP2K1/PRKACB/MAPK7/MAP3K4/CAMK2G/MAP2K3/MAPK10/PLA2G4A/MAPK13	31
KEGG	hsa04066	HIF-1 signaling pathway	35/1542	109/8135	0.0006725	0.002619	0.001357	IGF1/LDHA/FLT1/PFKFB3/HK2/ENO2/CDKN1A/MAPK3/CREBBP/PFKP/AKT1/MKNK1/VEGFA/LTBR/PIK3CD/PFKL/IFNG/ARNT/MAP2K2/ENO1/RPS6KB2/MTOR/HMOX1/PFKM/PGK1/MAP2K1/MKNK2/EIF4E/AKT2/PIK3R2/CAMK2G/PDHB/CUL2/PIK3CB/LDHC	35
KEGG	hsa04917	Prolactin signaling pathway	25/1542	70/8135	0.0006877	0.002634	0.001366	CCND2/MAPK3/AKT1/PIK3CD/MAP2K2/HRAS/KRAS/SOS1/MAPK14/IRF1/GRB2/TNFSF11/CCND1/MAP2K1/STAT1/AKT2/PIK3R2/PIK3CB/FOXO3/MAPK10/TNFRSF11A/MAPK13/SHC2/SLC2A2/STAT5A	25
KEGG	hsa00280	Valine, leucine and isoleucine degradation	19/1542	48/8135	0.000704	0.002634	0.001366	ALDH6A1/HADHA/HADH/BCKDHA/BCAT1/ALDH3A2/ACADS/HADHB/ACADSB/ALDH9A1/ALDH7A1/ECHS1/PCCB/HMGCS2/PCCA/AUH/DBT/MCCC2/HMGCL	19
KEGG	hsa04936	Alcoholic liver disease	43/1542	142/8135	0.0007069	0.002634	0.001366	TNFRSF1A/SCD/FASN/AKT1/CASP3/CD14/C5/TRA2B/MAP3K14/ADIPOQ/ALDH3A2/IKBKB/FAS/ALDH9A1/ALDH7A1/ADIPOR2/MAPK14/IFNA2/TRA2A/CCND1/CHUK/IRF3/SREBF1/LY96/CTNNB1/IRAK1/PRKAA1/CXCL8/FADD/IKBKE/AKT2/FASLG/TRADD/TRAF6/ADH1B/PRKAG1/FOXO3/ADH5/ACOX1/MAP2K3/PPARA/MAPK10/MAPK13	43
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	62/1542	223/8135	0.0007083	0.002634	0.001366	EPHX1/JUN/ABL2/CYP1A1/PLD2/MAPK3/CAT/CYC1/AKT1/VEGFA/PIK3CD/ABL1/UQCRC1/SLC25A6/NDUFV1/ARNT/MAP2K2/NDUFS2/MAP3K14/PLD1/HRAS/PTK2/PPIF/KRAS/MGST2/IKBKB/ARAF/NDUFB1/GSTO1/CBR1/PRKD2/NDUFA2/SOS1/NDUFS7/HGF/MAPK14/HMOX1/PRKCD/GRB2/BAD/COX5A/CHUK/MAP2K1/UQCR11/CYP1B1/COX7A2/AKT2/PIK3R2/PRKD1/SDHC/AKR1A1/PIK3CB/FOXO3/PTPRJ/NDUFC1/MAPK10/MET/NFE2L2/RAC1/NDUFS3/MAPK13/PRKD3	62
KEGG	hsa04370	VEGF signaling pathway	22/1542	59/8135	0.0007266	0.002672	0.001385	MAPK3/AKT1/VEGFA/PIK3CD/MAP2K2/HRAS/SPHK2/PTK2/PTGS2/KRAS/CDC42/MAPK14/PPP3CC/BAD/MAP2K1/AKT2/PIK3R2/PIK3CB/RAC1/PLA2G4A/MAPK13/SHC2	22
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	34/1542	106/8135	0.0008147	0.002933	0.001521	GNAI2/ATF4/PLD2/ARRB2/CDKN1A/MAPK3/ITPR2/CREB1/NR4A2/ADCY3/ARHGEF11/PLCB3/AKAP13/RXRA/PLCB2/PDE4D/MMP14/PLD1/ARAF/GNAS/RHOA/GNAI1/ITPR3/ADCY9/TNFSF11/GNA12/MAP2K1/MEF2A/PRKACB/RXRB/FGFR1/CYP24A1/CYP27B1/LRP6	34
KEGG	hsa05231	Choline metabolism in cancer	32/1542	98/8135	0.0008153	0.002933	0.001521	PIP5K1C/DGKZ/JUN/TSC2/PLD2/RHEB/MAPK3/AKT1/WAS/PIK3CD/MAP2K2/PLD1/HRAS/KRAS/CHKB/SOS1/RPS6KB2/MTOR/PDGFB/PIP5K1A/GRB2/PDGFA/MAP2K1/DGKD/SLC22A4/AKT2/PIK3R2/DGKQ/PIK3CB/MAPK10/RAC1/PLA2G4A	32
KEGG	hsa05133	Pertussis	26/1542	76/8135	0.001136	0.004017	0.002082	GNAI2/JUN/SERPING1/MAPK3/ITGAM/CFL1/ITGB1/CASP3/CD14/C5/NLRP3/IRF8/RHOA/ITGB2/MAPK14/IRF1/GNAI1/IRF3/CASP7/LY96/IRAK1/CXCL8/TRAF6/MAPK10/MAPK13/C1R	26
KEGG	hsa05134	Legionellosis	21/1542	57/8135	0.001141	0.004017	0.002082	CLK1/RAB1A/ITGAM/HSPA6/CASP3/NAIP/HSPA8/TLR5/CD14/HSF1/NFKB2/SEC22B/ITGB2/EEF1A2/SAR1A/HBS1L/CYCS/CASP7/HSPA1B/CXCL8/HSPD1	21
KEGG	hsa04625	C-type lectin receptor signaling pathway	33/1542	104/8135	0.001188	0.004137	0.002145	JUN/LSP1/MAPK3/ITPR2/AKT1/PIK3CD/STAT2/MAP3K14/NLRP3/HRAS/SYK/PTGS2/MALT1/KRAS/IKBKB/NFKB2/RHOA/EGR2/MAPK14/IRF1/RRAS/PRKCD/ITPR3/PPP3CC/CHUK/RELB/STAT1/IKBKE/AKT2/PIK3R2/PIK3CB/MAPK10/MAPK13	33
KEGG	hsa04658	Th1 and Th2 cell differentiation	30/1542	92/8135	0.0012	0.004137	0.002145	CD4/HLA-DMB/JUN/TYK2/RBPJ/MAPK3/HLA-DMA/IL2RG/NOTCH3/CD3D/IFNG/NOTCH2/STAT6/IKBKB/HLA-DOB/CD3G/PRKCQ/IL2RB/MAPK14/IL12RB1/PPP3CC/CHUK/STAT1/NFKBIB/HLA-DQB1/LCK/CD247/MAPK10/MAPK13/STAT5A	30
KEGG	hsa04621	NOD-like receptor signaling pathway	52/1542	184/8135	0.001243	0.00424	0.002198	GABARAP/OAS2/JUN/MAP1LC3B/TYK2/ATG12/MAPK3/ITPR2/TXN/TXNIP/GBP2/PLCB3/PKN1/TXN2/IFNAR1/CASP4/GABARAPL1/NAIP/IFNAR2/GBP1/TNFAIP3/STAT2/PLCB2/BIRC3/NAMPT/HSP90AB1/NLRP3/TANK/IKBKB/RHOA/HSP90AA1/MAPK14/IFNA2/PRKCD/MFN1/ITPR3/RBCK1/CHUK/IRF3/STAT1/NFKBIB/AIM2/CXCL8/FADD/IKBKE/CCL2/GABARAPL2/PSTPIP1/TRAF6/MAPK10/MAPK13/NLRP1	52
KEGG	hsa04926	Relaxin signaling pathway	39/1542	129/8135	0.001268	0.004281	0.002219	GNAI2/JUN/ATF4/VEGFB/ARRB2/MAPK3/CREB1/ADCY3/GNG7/GNG5/AKT1/PLCB3/VEGFA/PIK3CD/MMP9/MAP2K2/PLCB2/COL4A1/HRAS/KRAS/GNB2/SOS1/GNAS/GNG12/MAPK14/GNAI1/GRB2/ADCY9/MMP1/MAP2K1/PRKACB/AKT2/PIK3R2/PIK3CB/MAPK10/GNAO1/MAPK13/SHC2/COL4A4	39
KEGG	hsa04115	p53 signaling pathway	25/1542	73/8135	0.00138	0.004612	0.002391	CCND2/IGF1/ATM/TSC2/CDKN1A/SIVA1/TP53/TP53I3/CASP3/GADD45A/PMAIP1/THBS1/FAS/CDK2/CDK4/GADD45B/CCND1/CHEK1/CYCS/CDKN2A/MDM4/ATR/PPM1D/CCNB1/CDK1	25
KEGG	hsa04012	ErbB signaling pathway	28/1542	85/8135	0.001449	0.004746	0.00246	JUN/ABL2/CDKN1A/MAPK3/AKT1/PIK3CD/ABL1/MAP2K2/HRAS/PTK2/KRAS/ARAF/AREG/SOS1/RPS6KB2/MTOR/EREG/GRB2/BAD/MAP2K1/ERBB4/AKT2/PIK3R2/CAMK2G/PIK3CB/MAPK10/SHC2/STAT5A	28
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	31/1542	97/8135	0.001451	0.004746	0.00246	VAV1/PIP5K1C/HCK/PLD2/MAPK3/ARF6/INPPL1/AKT1/CFL1/FCGR3A/WAS/PIK3CD/INPP5D/MARCKS/PLD1/SPHK2/SYK/CDC42/ARPC1B/RPS6KB2/PIP5K1A/PRKCD/ARPC2/MAP2K1/AKT2/DNM2/PIK3R2/ARPC1A/PIK3CB/RAC1/PLA2G4A	31
KEGG	hsa05225	Hepatocellular carcinoma	48/1542	168/8135	0.001463	0.004746	0.00246	GSTP1/CDKN1A/MAPK3/TP53/AKT1/TXNRD2/PIK3CD/CSNK1A1/SMARCC2/TXNRD1/FZD2/GADD45A/MAP2K2/HRAS/KRAS/MGST2/ARAF/GSTO1/SOS1/RPS6KB2/MTOR/BAK1/ACTL6A/HGF/FZD7/HMOX1/GRB2/CDK4/GADD45B/BAD/CCND1/SMARCD2/RB1/CTNNB1/MAP2K1/CDKN2A/TGFB2/ARID1A/AKT2/DVL3/PIK3R2/FZD5/PIK3CB/FZD6/MET/NFE2L2/SHC2/LRP6	48
KEGG	hsa05224	Breast cancer	43/1542	147/8135	0.001528	0.004911	0.002546	IGF1/JUN/HES1/CDKN1A/MAPK3/TP53/AKT1/PIK3CD/CSNK1A1/NOTCH3/FZD2/GADD45A/MAP2K2/NOTCH2/HRAS/KRAS/ARAF/SOS1/NFKB2/RPS6KB2/MTOR/BAK1/FZD7/GRB2/CDK4/FGF9/GADD45B/TNFSF11/CCND1/RB1/FGF1/CTNNB1/MAP2K1/AKT2/FGFR1/DVL3/PIK3R2/FZD5/PIK3CB/FGF7/FZD6/SHC2/LRP6	43
KEGG	hsa00051	Fructose and mannose metabolism	14/1542	33/8135	0.001594	0.005074	0.00263	FBP1/PFKFB3/HK2/SORD/PFKP/PFKL/TSTA3/MPI/AKR1B1/PFKM/PFKFB2/FPGT/PMM1/TPI1	14
KEGG	hsa04721	Synaptic vesicle cycle	26/1542	78/8135	0.001743	0.005496	0.002849	AP2B1/ATP6V0A1/ATP6V0C/AP2S1/STX3/TCIRG1/CLTB/ATP6V1A/CLTA/ATP6V1B2/UNC13B/ATP6V1G1/ATP6V1H/ATP6V1D/AP2M1/ATP6V1E1/VAMP2/DNM2/AP2A2/SLC6A2/DNM1/ATP6V0E2/NAPA/SLC1A3/SLC1A1/ATP6V0D1	26
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	115/1542	476/8135	0.002172	0.006782	0.003516	TNFRSF1A/UBE2J1/RAB1A/MAP1LC3B/ATF4/TUBB2A/CHMP2B/MAPK3/ITPR2/PRNP/CAT/UBA1/CYC1/PINK1/PSEN2/PLCB3/GPX1/RB1CC1/GPX3/DDIT3/PSMB4/TUBB/CASP3/UQCRC1/KIF5B/HIP1/CSNK1A1/SLC25A6/NDUFV1/FZD2/ATP2A3/MAP2K2/NDUFS2/PLCB2/PSMB3/PSMD3/TANK/HRAS/PPIF/PSMD11/PTGS2/CAPN2/KRAS/PSMA1/GPX7/ARAF/FAS/NDUFB1/SPG11/DCTN3/KIF5C/XBP1/ACTR1B/NDUFA2/MTOR/NDUFS7/UBC/BAK1/FZD7/MAPK14/UBE2G2/HTT/ATXN3/FIG4/MFN1/ITPR3/PPP3CC/NEFH/BAD/PSMD14/COX5A/TRAP1/CYCS/CASP7/CAPN1/ATXN2L/CTNNB1/MAP2K1/RPS27A/UQCR11/ULK2/PSMC6/COX7A2/PSMA3/TUBB2B/PSMC1/FADD/ADRM1/FASLG/CSNK2A1/UBE2L6/DVL3/DLG4/WIPI2/CAMK2G/PSMB1/SDHC/ATG2A/FZD5/PSMA4/CCS/FZD6/PSMC4/MAP2K3/NDUFC1/MAPK10/RAC1/CSF1/NDUFS3/MAPK13/GPX2/PSMD13/LRP6/SIGMAR1/PSMD8	115
KEGG	hsa05416	Viral myocarditis	21/1542	60/8135	0.002395	0.007408	0.00384	HLA-DMB/CD55/ABL2/FYN/HLA-DMA/ABL1/EIF4G2/CASP3/CD80/CAV1/HLA-DOB/CXADR/ITGB2/CCND1/CYCS/HLA-DQB1/CD28/LAMA2/HLA-A/ITGAL/RAC1	21
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	38/1542	131/8135	0.003272	0.01003	0.005198	VAV1/MAPK3/TYROBP/FYN/IFNAR1/FCGR3A/CD48/PIK3CD/CASP3/IFNAR2/IFNG/MAP2K2/HRAS/SYK/KRAS/ARAF/FAS/SOS1/ITGB2/ICAM2/IFNA2/GRB2/PPP3CC/SH3BP2/CSF2/TNFSF10/MAP2K1/LCK/FASLG/CD247/PIK3R2/PIK3CB/HLA-A/LCP2/ITGAL/RAC1/GZMB/SHC2	38
KEGG	hsa05146	Amoebiasis	31/1542	102/8135	0.003492	0.0106	0.005497	RAB5C/CD1C/IL1R2/ITGAM/PLCB3/LAMB2/PIK3CD/CASP3/CD14/IFNG/FN1/PLCB2/COL4A1/LAMC1/PTK2/GNAS/ITGB2/CD1A/IL1R1/CSF2/PRKACB/CXCL8/TGFB2/PIK3R2/ACTN4/LAMA2/SERPINB6/C8B/PIK3CB/COL4A4/CD1E	31
KEGG	hsa04922	Glucagon signaling pathway	32/1542	107/8135	0.003995	0.01202	0.006232	FBP1/LDHA/PYGL/ATF4/PGAM1/CREBBP/ITPR2/CREB1/PFKP/AKT1/PLCB3/PHKB/PYGB/PFKL/PLCB2/GNAS/GCGR/PFKM/ITPR3/PPP3CC/PHKG2/GCG/PRKAA1/PRKACB/PHKA2/AKT2/CAMK2G/PDHB/PRKAG1/PPARA/LDHC/SLC2A2	32
KEGG	hsa04640	Hematopoietic cell lineage	30/1542	99/8135	0.00422	0.01258	0.006523	CD4/CSF1R/HLA-DMB/CD55/CD1C/CD37/IL1R2/ITGAM/HLA-DMA/CD33/CD2/CD3D/CD14/IL3RA/HLA-DOB/CD3G/CD1A/ITGA1/CSF3R/IL1R1/CSF2/HLA-DQB1/CD44/CD22/ANPEP/MME/CD36/DNTT/CSF1/CD1E	30
KEGG	hsa04330	Notch signaling pathway	20/1542	59/8135	0.004579	0.01353	0.007015	HES1/RBPJ/CREBBP/CIR1/PSEN2/NOTCH3/NOTCH2/RFNG/HDAC1/NCSTN/MFNG/CTBP1/SNW1/TLE1/KAT2A/KAT2B/DTX4/DVL3/ADAM17/NCOR2	20
KEGG	hsa03250	Viral life cycle - HIV-1	21/1542	63/8135	0.004652	0.01363	0.007063	CD4/SUPT5H/CREBBP/PIN1/CCNT2/APOBEC3B/SERINC5/APOBEC3F/HGS/CCR5/MLLT1/NELFB/APOBEC3C/MX2/SAMHD1/KAT2A/RAN/KAT2B/BST2/MX1/PSIP1	21
KEGG	hsa05010	Alzheimer disease	93/1542	384/8135	0.00517	0.01501	0.007781	TNFRSF1A/ATF4/TUBB2A/MAPK3/ITPR2/CYC1/PSEN2/AKT1/PLCB3/RB1CC1/DDIT3/PSMB4/TUBB/PIK3CD/CASP3/UQCRC1/KIF5B/CSNK1A1/SLC25A6/NDUFV1/FZD2/ATP2A3/MAP2K2/LRP1/NDUFS2/PLCB2/PSMB3/PSMD3/HRAS/PPIF/PSMD11/PTGS2/CAPN2/KRAS/PSMA1/NCSTN/IKBKB/ARAF/FAS/ADAM10/NDUFB1/RTN4/KIF5C/XBP1/SLC39A8/NDUFA2/IRS1/MTOR/LPL/NDUFS7/FZD7/ITPR3/PPP3CC/BAD/PSMD14/COX5A/CHUK/CYCS/CASP7/CAPN1/CTNNB1/MAP2K1/UQCR11/ULK2/PSMC6/COX7A2/PSMA3/TUBB2B/PSMC1/FADD/AKT2/ADRM1/CSNK2A1/DVL3/PIK3R2/WIPI2/PSMB1/MME/SDHC/ATG2A/FZD5/PSMA4/PIK3CB/FZD6/PSMC4/NDUFC1/MAPK10/CSF1/NDUFS3/ADAM17/PSMD13/LRP6/PSMD8	93
KEGG	hsa04014	Ras signaling pathway	60/1542	232/8135	0.005321	0.01531	0.007939	IGF1/RAB5C/FLT1/CSF1R/ETS2/SHOC2/ABL2/PLD2/VEGFB/MAPK3/ARF6/GNG7/RAP1B/GNG5/AKT1/VEGFA/RIN1/PIK3CD/ABL1/REL/MAP2K2/RGL2/PLD1/HRAS/KRAS/RALA/CDC42/GNB2/IKBKB/RGL1/SOS1/RHOA/PDGFB/GNG12/HGF/RRAS/GRB2/FGF9/PDGFA/BAD/RASGRF1/FGF1/CHUK/MAP2K1/PRKACB/AKT2/FASLG/FGFR1/PIK3R2/NF1/PIK3CB/FGF7/MAPK10/MET/RAC1/CSF1/PLA2G4A/RASGRP1/RALBP1/SHC2	60
KEGG	hsa05016	Huntington disease	76/1542	306/8135	0.005701	0.01627	0.008432	TGM2/TUBB2A/AP2B1/CREBBP/CREB1/PPARG/TP53/CYC1/PLCB3/GPX1/RB1CC1/AP2S1/GPX3/PSMB4/TUBB/POLR2L/CASP3/UQCRC1/KIF5B/HIP1/SLC25A6/NDUFV1/CLTB/NDUFS2/PLCB2/PSMB3/PSMD3/CLTA/HDAC1/PPIF/PSMD11/PSMA1/GPX7/NDUFB1/RCOR1/DCTN3/KIF5C/ACTR1B/NDUFA2/MTOR/NDUFS7/POLR2E/HTT/PSMD14/COX5A/CYCS/UQCR11/ULK2/AP2M1/PSMC6/COX7A2/PSMA3/TUBB2B/PSMC1/ADRM1/POLR2A/POLR2I/DLG4/AP2A2/WIPI2/NRF1/PSMB1/TBPL1/SDHC/ATG2A/PSMA4/POLR2J/PSMC4/NDUFC1/MAPK10/SLC1A3/NDUFS3/KCNJ10/GPX2/PSMD13/PSMD8	76
KEGG	hsa04670	Leukocyte transendothelial migration	33/1542	114/8135	0.006081	0.0172	0.008918	NCF4/EZR/VAV1/GNAI2/SIPA1/RAP1B/CD99/ITGAM/ROCK1/ITGB1/PIK3CD/MMP9/RHOH/PTK2/PECAM1/CDC42/RHOA/ITGB2/ARHGAP35/MAPK14/GNAI1/CTNNB1/PIK3R2/ACTN4/ITK/PIK3CB/CXCL12/ROCK2/ITGAL/RAC1/MAPK13/ARHGAP5/MYL12B	33
KEGG	hsa05226	Gastric cancer	41/1542	149/8135	0.006434	0.01805	0.009355	CDKN1A/MAPK3/TP53/AKT1/PIK3CD/CSNK1A1/FZD2/GADD45A/MAP2K2/RXRA/HRAS/KRAS/ARAF/SOS1/RPS6KB2/MTOR/BAK1/HGF/FZD7/CDK2/GRB2/FGF9/GADD45B/CCND1/RB1/FGF1/CTNNB1/MAP2K1/TGFB2/AKT2/RXRB/DVL3/PIK3R2/JUP/FZD5/PIK3CB/FGF7/FZD6/MET/SHC2/LRP6	41
KEGG	hsa05100	Bacterial invasion of epithelial cells	24/1542	77/8135	0.006751	0.01878	0.009734	RHOG/HCLS1/ILK/ITGB1/PIK3CD/CLTB/CAV1/FN1/ELMO1/CLTA/PTK2/CDC42/ARPC1B/RHOA/ARPC2/CTNNB1/DNM2/PIK3R2/DNM1/ARPC1A/PIK3CB/MET/RAC1/SHC2	24
KEGG	hsa04920	Adipocytokine signaling pathway	22/1542	69/8135	0.006927	0.01911	0.009905	TNFRSF1A/AKT1/RXRA/ADIPOQ/IKBKB/ADIPOR2/IRS1/MTOR/PRKCQ/STK11/CHUK/NFKBIB/PRKAA1/AKT2/RXRB/TRADD/SLC2A4/CD36/PRKAG1/PPARA/MAPK10/NPY	22
KEGG	hsa04915	Estrogen signaling pathway	38/1542	138/8135	0.008389	0.02295	0.0119	GNAI2/JUN/ATF4/MAPK3/ITPR2/CREB1/ADCY3/AKT1/PLCB3/HSPA6/PIK3CD/HSPA8/MMP9/MAP2K2/PLCB2/HSP90AB1/HRAS/KRAS/CTSD/SOS1/GNAS/HSP90AA1/PRKCD/KCNJ9/GNAI1/GRB2/ITPR3/ADCY9/EBAG9/HSPA1B/MAP2K1/PRKACB/AKT2/KCNJ5/PIK3R2/PIK3CB/GNAO1/SHC2	38
KEGG	hsa03040	Spliceosome	40/1542	147/8135	0.008616	0.02338	0.01212	SYF2/SART1/PRPF8/SRSF7/SF3A1/PRPF6/LSM2/HSPA6/SF3B4/HSPA8/SMNDC1/TRA2B/SNRNP70/LSM6/EIF4A3/DHX15/BUD31/AQR/SNRPB2/PRPF19/DDX23/SRSF10/TRA2A/SNRPA/SNW1/SF3A3/HNRNPA1/SRSF8/HSPA1B/SNRPC/SNRPA1/PRPF31/PCBP1/PRPF18/PPIH/LSM4/U2AF1/RBM25/SF3A2/HNRNPK	40
KEGG	hsa00640	Propanoate metabolism	12/1542	32/8135	0.01086	0.02923	0.01515	LDHA/ALDH6A1/SUCLG2/HADHA/BCKDHA/ACADS/ECHS1/PCCB/PCCA/DBT/ACOX1/LDHC	12
KEGG	hsa04070	Phosphatidylinositol signaling system	28/1542	97/8135	0.01138	0.03037	0.01574	CDS1/PIP5K1C/DGKZ/ITPR2/INPPL1/PLCB3/INPP5F/PIK3CD/INPP5D/PLCB2/INPP5E/PIP4K2B/IMPA2/IMPA1/PIP4K2A/OCRL/IP6K1/PIP5K1A/ITPR3/CDIPT/INPP1/MTMR4/PPIP5K2/DGKD/PIK3R2/DGKQ/PIK3CB/SYNJ2	28
KEGG	hsa04137	Mitophagy - animal	22/1542	72/8135	0.01186	0.0314	0.01628	GABARAP/JUN/MAP1LC3B/ATF4/TP53/PINK1/TFE3/GABARAPL1/BNIP3L/NBR1/HRAS/KRAS/CALCOCO2/UBC/RRAS/MFN1/TAX1BP1/RPS27A/GABARAPL2/CSNK2A1/FOXO3/MAPK10	22
KEGG	hsa04978	Mineral absorption	19/1542	60/8135	0.01255	0.03276	0.01698	MT1X/ATP2B4/ATP1A1/MT1E/MT1A/ATP1B3/MT1B/ATP2B1/MT1F/MT1H/MT2A/HMOX1/ATP7A/HEPH/SLC9A3/FTH1/FTL/ATOX1/ATP7B	19
KEGG	hsa01200	Carbon metabolism	32/1542	115/8135	0.0126	0.03276	0.01698	FBP1/ALDH6A1/IDH2/TKT/HK2/IDH3G/PGAM1/ENO2/SUCLG2/CAT/IDH3B/PFKP/ACO2/ACO1/PFKL/ACADS/PC/ME1/ENO1/PFKM/PSPH/ECHS1/IDH1/PGK1/PCCB/TPI1/ESD/PCCA/PDHB/SDHC/ADH5/ACOX1	32
KEGG	hsa04923	Regulation of lipolysis in adipocytes	18/1542	56/8135	0.01267	0.03276	0.01698	GNAI2/ADCY3/AKT1/PIK3CD/NPY1R/PTGS2/GNAS/IRS1/PTGER3/GNAI1/ADCY9/MGLL/PRKACB/AKT2/PIK3R2/PIK3CB/ABHD5/NPY	18
KEGG	hsa04144	Endocytosis	62/1542	251/8135	0.01322	0.03392	0.01758	RAB5C/ARAP1/FOLR2/PIP5K1C/RAB11B/CAPZB/PLD2/ARRB2/AP2B1/SH3GL1/CHMP2B/ARF6/ARF3/WWP1/GBF1/AP2S1/IL2RG/HSPA6/ARFGAP3/KIF5B/HSPA8/CLTB/CAV1/ITCH/PSD3/CLTA/PLD1/PML/HRAS/HGS/RNF41/CDC42/SNX1/KIF5C/ARF5/ARPC1B/ZFYVE16/RHOA/CCR5/IL2RB/PIP5K1A/PRKCI/SNX2/ARFGEF1/ARPC2/VPS26A/CAPZA1/ARFGAP2/VPS45/HSPA1B/AP2M1/SH3GLB1/CYTH1/DNM2/NEDD4L/AP2A2/DNM1/TRAF6/ARPC1A/HLA-A/ARF4/CHMP7	62
KEGG	hsa04530	Tight junction	44/1542	169/8135	0.01374	0.03497	0.01813	EZR/CD1C/JUN/HCLS1/RAPGEF2/PPP2R1A/ROCK1/PPP2R2A/ITGB1/WAS/RAP2C/CDC42/ARPC1B/TJP3/PCNA/RHOA/CD1A/SCRIB/ARHGEF18/PRKCI/MPDZ/CDK4/STK11/CCND1/ARPC2/RDX/PRKAA1/PRKACB/SYMPK/MYL6B/MYH9/ARHGEF2/NEDD4L/ACTN4/ARPC1A/PRKAG1/HSPA4/MAGI1/MAPK10/ROCK2/RAC1/MYL12B/NF2/CD1E	44
KEGG	hsa00562	Inositol phosphate metabolism	22/1542	73/8135	0.01402	0.03532	0.01831	ALDH6A1/PIP5K1C/INPPL1/PLCB3/INPP5F/PIK3CD/INPP5D/PLCB2/INPP5E/PIP4K2B/IMPA2/IMPA1/PIP4K2A/OCRL/PIP5K1A/FIG4/CDIPT/INPP1/MTMR4/TPI1/PIK3CB/SYNJ2	22
KEGG	hsa03410	Base excision repair	12/1542	33/8135	0.01419	0.03532	0.01831	MPG/APEX1/PARP4/XRCC1/PCNA/PARP2/PARP1/POLD1/POLD4/LIG1/APEX2/MBD4	12
KEGG	hsa04130	SNARE interactions in vesicular transport	12/1542	33/8135	0.01419	0.03532	0.01831	VAMP5/STX3/STX6/SNAP23/SEC22B/VTI1B/GOSR2/VAMP8/VAMP2/STX8/STX16/STX11	12
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/1542	53/8135	0.0155	0.03802	0.01971	AP2B1/ATP2B4/PLCB3/ATP1A1/AP2S1/ATP1B3/CLTB/ATP2B1/PLCB2/CLTA/GNAS/ADCY9/PRKACB/AP2M1/DNM2/AP2A2/DNM1	17
KEGG	hsa03022	Basal transcription factors	15/1542	45/8135	0.01551	0.03802	0.01971	GTF2B/TAF6/GTF2F1/TAF7/TAF15/TAF10/GTF2H2/CDK7/GTF2H4/CCNH/TAF12/GTF2E2/TBPL1/GTF2H5/TAF5L	15
KEGG	hsa04612	Antigen processing and presentation	23/1542	78/8135	0.01592	0.03876	0.02009	CD4/HLA-DMB/CREB1/HLA-DMA/HSPA6/HSPA8/PSME3/IFNG/HSP90AB1/TAP1/HLA-DOB/LGMN/PSME1/HSP90AA1/CIITA/HSPA1B/HLA-DQB1/KIR2DL4/PDIA3/RFX5/HLA-A/HSPA4/CTSL	23
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	53/1542	212/8135	0.01659	0.04009	0.02078	EPHX1/RPS6KA2/GNAI2/JUN/ATF4/CYP1A1/ARRB2/MAPK3/CREB1/ADCY3/AKT1/VEGFA/PIK3CD/ARNT/MAP2K2/RXRA/NOTCH2/HSP90AB1/HRAS/KRAS/MGST2/KLF4/GSTO1/SOS1/GNAS/RPS6KB2/KPNA2/MTOR/HSP90AA1/GNAI1/GRB2/FGF9/ADCY9/TNFSF11/BAD/CCND1/RB1/MAP2K1/PRKACB/CYP1B1/AIP/KPNA3/IKBKE/AKT2/RXRB/PIK3R2/RPS6KA3/PIK3CB/FGF7/PPARA/PTGES3/STAT5A/CDC6	53
KEGG	hsa01523	Antifolate resistance	11/1542	30/8135	0.01737	0.04137	0.02144	FOLR2/ABCC1/FPGS/GART/IKBKB/ABCG2/ATIC/CHUK/ABCC5/DHFR/MTHFR	11
KEGG	hsa05020	Prion disease	66/1542	273/8135	0.01737	0.04137	0.02144	NCF4/ATF4/TUBB2A/MAPK3/ITPR2/PRNP/CREB1/CYC1/FYN/DDIT3/HSPA6/PSMB4/TUBB/PIK3CD/CASP3/UQCRC1/KIF5B/SLC25A6/HSPA8/NDUFV1/CAV1/C5/NDUFS2/PSMB3/PSMD3/LAMC1/PPIF/PSMD11/PSMA1/NDUFB1/KIF5C/NDUFA2/NDUFS7/MAPK14/PRKCD/ITPR3/PPP3CC/BAD/PSMD14/COX5A/CYCS/HSPA1B/UQCR11/PRKACB/PSMC6/COX7A2/PSMA3/TUBB2B/PSMC1/ADRM1/CSNK2A1/PIK3R2/C7/PSMB1/SDHC/PSMA4/C8B/PIK3CB/PSMC4/NDUFC1/MAPK10/RAC1/NDUFS3/MAPK13/PSMD13/PSMD8	66
KEGG	hsa01230	Biosynthesis of amino acids	22/1542	75/8135	0.01926	0.04521	0.02344	IDH2/TKT/IDH3G/PGAM1/ASNS/ENO2/IDH3B/PFKP/ACO2/ACO1/PFKL/MAT2A/BCAT1/PC/ENO1/CTH/PFKM/PSPH/IDH1/PGK1/TPI1/ASL	22
KEGG	hsa03320	PPAR signaling pathway	22/1542	75/8135	0.01926	0.04521	0.02344	GK/ILK/PPARG/SCD/PLIN2/PLTP/PPARD/RXRA/ADIPOQ/ME1/FADS2/LPL/CYP27A1/UBC/MMP1/OLR1/HMGCS2/RXRB/CD36/ACOX1/FABP5/PPARA	22
KEGG	hsa03430	Mismatch repair	9/1542	23/8135	0.01951	0.04548	0.02357	RPA1/RFC5/MLH3/PCNA/RFC2/POLD1/POLD4/LIG1/MSH2	9
KEGG	hsa04540	Gap junction	25/1542	88/8135	0.01975	0.04572	0.0237	GNAI2/TUBB2A/MAPK3/ITPR2/ADCY3/PLCB3/TUBB/HTR2B/MAP2K2/PLCB2/HRAS/KRAS/SOS1/GNAS/PDGFB/GNAI1/GRB2/ITPR3/PDGFA/ADCY9/MAP2K1/PRKACB/TUBB2B/MAPK7/CDK1	25
KEGG	hsa00010	Glycolysis / Gluconeogenesis	20/1542	67/8135	0.02065	0.04746	0.0246	FBP1/LDHA/HK2/PGAM1/ENO2/PFKP/ALDH3B1/PFKL/ALDH3A2/ENO1/ALDH9A1/ALDH7A1/PFKM/PGK1/TPI1/PDHB/ADH1B/AKR1A1/ADH5/LDHC	20
KEGG	hsa04966	Collecting duct acid secretion	10/1542	27/8135	0.02128	0.04857	0.02518	ATP6V0A1/ATP6V0C/TCIRG1/ATP6V1A/ATP6V1B2/ATP6V1G1/ATP6V1D/ATP6V1E1/ATP6V0E2/ATP6V0D1	10
KEGG	hsa04120	Ubiquitin mediated proteolysis	37/1542	142/8135	0.02219	0.05031	0.02608	DDB1/UBE2J1/UBE2D3/UBA1/ANAPC15/CUL4B/WWP1/ITCH/BIRC3/ANAPC13/PML/UBE3B/ANAPC5/UBA3/UBA2/WWP2/RHOBTB1/PRPF19/UBC/UBE2H/CUL4A/PPIL2/UBE2G2/UBE2M/CDC16/UBE4B/RPS27A/CUL1/FANCL/MGRN1/UBE2L6/NEDD4L/CUL2/TRAF6/CUL7/AIRE/TRIM32	37
KEGG	hsa00071	Fatty acid degradation	14/1542	43/8135	0.02344	0.05261	0.02727	HADHA/GCDH/HADH/ECI1/ALDH3A2/ACADS/HADHB/ACADSB/ALDH9A1/ALDH7A1/ECHS1/ADH1B/ADH5/ACOX1	14
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	27/1542	98/8135	0.02352	0.05261	0.02727	IGF1/ITPR2/HRH1/ADCY3/PLCB3/PIK3CD/HTR2B/IL1RAP/PLCB2/GNAS/PRKCQ/MAPK14/PRKCD/IL1R1/ITPR3/ADCY9/PRKACB/PIK3R2/PPP1CB/CAMK2G/PIK3CB/MAP2K3/MAPK10/PRKCH/PTGER2/PLA2G4A/MAPK13	27
KEGG	hsa04929	GnRH secretion	19/1542	64/8135	0.02508	0.0557	0.02888	SPP1/ARRB2/MAPK3/ITPR2/AKT1/PLCB3/PIK3CD/MAP2K2/PLCB2/HRAS/KRAS/KCNJ9/ITPR3/MAP2K1/AKT2/KCNJ5/PIK3R2/KCNN4/PIK3CB	19
KEGG	hsa04730	Long-term depression	18/1542	60/8135	0.02593	0.05721	0.02966	IGF1/GNAI2/MAPK3/ITPR2/PPP2R1A/PLCB3/MAP2K2/PLCB2/HRAS/KRAS/ARAF/GNAS/GNAI1/ITPR3/GNA12/MAP2K1/PLA2G4A/GNAO1	18
KEGG	hsa00920	Sulfur metabolism	5/1542	10/8135	0.0263	0.05764	0.02988	PAPSS1/MPST/PAPSS2/TST/SUOX	5
KEGG	hsa04630	JAK-STAT signaling pathway	41/1542	162/8135	0.02665	0.05803	0.03008	CCND2/TYK2/CDKN1A/CREBBP/PIM1/MCL1/AKT1/IL10RA/IFNAR1/IL2RG/PIK3CD/FHL1/IFNAR2/OSMR/IFNG/STAT2/IL3RA/STAT6/IL15/HRAS/IL24/SOS1/MTOR/PDGFB/IL2RB/IL12RB1/IFNA2/CSF3R/GRB2/GHR/PDGFA/CCND1/IL13RA1/CSF2/STAT1/AKT2/PIK3R2/PIK3CB/GH1/IL27RA/STAT5A	41
KEGG	hsa00450	Selenocompound metabolism	7/1542	17/8135	0.02862	0.06191	0.03209	TXNRD2/PAPSS1/TXNRD1/CTH/PAPSS2/SEPHS2/SEPHS1	7
KEGG	hsa03030	DNA replication	12/1542	36/8135	0.02885	0.062	0.03214	MCM5/RPA1/RFC5/POLA1/MCM2/PCNA/RFC2/POLA2/POLD1/POLD4/LIG1/MCM6	12
KEGG	hsa04921	Oxytocin signaling pathway	39/1542	154/8135	0.02977	0.06358	0.03296	CAMK1/GNAI2/JUN/CDKN1A/MAPK3/ITPR2/ADCY3/PLCB3/RCAN1/ROCK1/MAP2K2/PLCB2/EEF2/HRAS/PTGS2/KRAS/GNAS/RHOA/MYLK/KCNJ9/GNAI1/ITPR3/PPP3CC/ADCY9/CCND1/MAP2K1/PRKAA1/PRKACB/MYL6B/MAPK7/RGS2/KCNJ5/PPP1CB/CAMK2G/PRKAG1/ROCK2/PLA2G4A/GNAO1/PPP1R12A	39
KEGG	hsa01212	Fatty acid metabolism	17/1542	57/8135	0.03158	0.067	0.03473	TECR/HADHA/SCD/FASN/HSD17B8/HADH/HSD17B4/ACADS/HADHB/ACADSB/FADS2/CBR4/ELOVL2/ECHS1/PPT1/ELOVL5/ACOX1	17
KEGG	hsa04728	Dopaminergic synapse	34/1542	132/8135	0.03221	0.06792	0.03521	GNAI2/ATF4/ARRB2/ITPR2/CREB1/GNG7/GNG5/AKT1/PPP2R1A/PLCB3/COMT/PPP2R2A/KIF5B/PLCB2/GNB2/KIF5C/GNAS/GSK3A/GNG12/MAPK14/KCNJ9/GNAI1/ITPR3/PPP3CC/PRKACB/AKT2/PPP2R5D/KCNJ5/PPP1CB/CAMK2G/ARNTL/MAPK10/GNAO1/MAPK13	34
KEGG	hsa03018	RNA degradation	22/1542	79/8135	0.03421	0.07166	0.03715	ENO2/PAN2/BTG1/CNOT3/LSM2/PFKP/PFKL/MPHOSPH6/EDC4/LSM6/CNOT1/PARN/ENO1/BTG3/SKIV2L/TOB1/HSPA9/PFKM/C1D/EXOSC2/HSPD1/LSM4	22
KEGG	hsa04216	Ferroptosis	13/1542	41/8135	0.03513	0.07314	0.03791	MAP1LC3B/PRNP/TP53/NCOA4/SLC39A8/CP/HMOX1/ALOX15/FTH1/SLC7A11/GCLM/PCBP1/FTL	13
KEGG	hsa04720	Long-term potentiation	19/1542	67/8135	0.03944	0.08156	0.04228	RPS6KA2/ATF4/MAPK3/CREBBP/ITPR2/RAP1B/PLCB3/MAP2K2/PLCB2/HRAS/KRAS/ARAF/ITPR3/PPP3CC/MAP2K1/PRKACB/PPP1CB/CAMK2G/RPS6KA3	19
KEGG	hsa04141	Protein processing in endoplasmic reticulum	42/1542	171/8135	0.03967	0.08156	0.04228	ERP29/PRKCSH/UBE2J1/DNAJB1/ATF4/GANAB/UBE2D3/OS9/DDIT3/HSPA6/HSPA8/CKAP4/HSP90AB1/SEC24C/SEC62/CAPN2/XBP1/BAK1/HSP90AA1/UBE2G2/MOGS/ATXN3/SAR1A/UBE4B/CAPN1/HSPA1B/RAD23B/STT3A/CUL1/PDIA3/SEC24B/SEC61G/EDEM1/UBXN1/DDOST/SEC24A/BAG2/RAD23A/RPN1/BCAP31/MAPK10/NFE2L2	42
KEGG	hsa05012	Parkinson disease	62/1542	266/8135	0.04151	0.08481	0.04396	GNAI2/UBE2J1/ATF4/TUBB2A/ITPR2/TXN/UBA1/TP53/CYC1/PINK1/TXN2/DDIT3/PSMB4/TUBB/CASP3/UQCRC1/KIF5B/SLC25A6/NDUFV1/NDUFS2/PSMB3/PSMD3/PPIF/PSMD11/PSMA1/NDUFB1/KIF5C/XBP1/SLC39A8/NDUFA2/GNAS/NDUFS7/UBC/UBE2G2/GNAI1/MFN1/ITPR3/PSMD14/COX5A/TRAP1/CYCS/RPS27A/UQCR11/PRKACB/PSMC6/COX7A2/PSMA3/TUBB2B/PSMC1/ADRM1/UBE2L6/CAMK2G/PSMB1/SDHC/PSMA4/PSMC4/NDUFC1/MAPK10/NFE2L2/NDUFS3/PSMD13/PSMD8	62
KEGG	hsa04610	Complement and coagulation cascades	23/1542	85/8135	0.04204	0.08537	0.04425	SERPINA1/F13A1/CD55/SERPING1/ITGAM/C5/CPB2/CLU/F3/ITGB2/PROCR/PLAUR/CFHR2/PROS1/CFD/FGG/F5/CFI/C7/C8B/KLKB1/C1R/F2R	23
KEGG	hsa00380	Tryptophan metabolism	13/1542	42/8135	0.04235	0.08547	0.04431	CYP1A1/CAT/HADHA/GCDH/HADH/ALDH3A2/KYNU/ALDH9A1/ALDH7A1/ECHS1/CYP1B1/IDO1/HAAO	13
KEGG	hsa05340	Primary immunodeficiency	12/1542	38/8135	0.0433	0.08687	0.04503	CD4/BTK/IL2RG/CD3D/ADA/TAP1/BLNK/CIITA/ICOS/RFX5/LCK/AIRE	12
KEGG	hsa00020	Citrate cycle (TCA cycle)	10/1542	30/8135	0.04413	0.088	0.04562	IDH2/IDH3G/SUCLG2/IDH3B/ACO2/ACO1/PC/IDH1/PDHB/SDHC	10
KEGG	hsa05140	Leishmaniasis	21/1542	77/8135	0.04672	0.09261	0.04801	NCF4/HLA-DMB/JUN/MAPK3/ITGAM/HLA-DMA/FCGR3A/ITGB1/IFNG/PTGS2/HLA-DOB/ITGB2/MAPK14/EEF1A2/IRAK1/STAT1/NFKBIB/HLA-DQB1/TGFB2/TRAF6/MAPK13	21
KEGG	hsa00620	Pyruvate metabolism	14/1542	47/8135	0.04879	0.09612	0.04983	LDHA/ALDH3A2/PC/ME1/HAGH/ACYP1/ALDH9A1/ALDH7A1/GRHPR/PDHB/ADH1B/AKR1A1/ADH5/LDHC	14
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1542	100/8135	0.05041	0.09841	0.05101	CSF1R/TNFRSF1A/CXCL9/IL10RA/IL2RG/TNFRSF14/LTBR/TNFSF14/CCL7/CCR7/CCL20/PPBP/IL24/CCR5/IL2RB/TNFSF10/CCR6/CXCL8/CCL2/CCL16/CCR4/CXCL13/XCL1/CXCL12/CCL3/CSF1	26
KEGG	hsa04940	Type I diabetes mellitus	13/1542	43/8135	0.05054	0.09841	0.05101	HLA-DMB/HLA-DMA/CD80/IFNG/FAS/HLA-DOB/HLA-DQB1/CPE/CD28/FASLG/HSPD1/HLA-A/GZMB	13
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	7/1542	19/8135	0.05243	0.1015	0.05261	IDH2/IDH3G/IDH3B/ACO2/ACO1/BCAT1/IDH1	7
KEGG	hsa00410	beta-Alanine metabolism	10/1542	31/8135	0.05447	0.1048	0.05434	ALDH6A1/HADHA/ALDH3B1/ALDH3A2/ACADS/ALDH9A1/ALDH7A1/ECHS1/DPYD/ACOX1	10
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	35/1542	143/8135	0.05898	0.1123	0.05822	IGF1/PCGF1/MAPK3/AKT1/ID1/PIK3CD/FZD2/MAP2K2/HRAS/KRAS/SETDB1/ACVR1/KLF4/JARID2/FZD7/MAPK14/SKIL/GRB2/ZFHX3/HESX1/CTNNB1/MAP2K1/ZIC3/ID3/INHBA/AKT2/KAT6A/ID2/FGFR1/DVL3/PIK3R2/FZD5/PIK3CB/FZD6/MAPK13	35
KEGG	hsa04622	RIG-I-like receptor signaling pathway	19/1542	70/8135	0.05904	0.1123	0.05822	ATG12/PIN1/DDX3X/TBKBP1/TANK/IKBKB/MAPK14/IFNA2/CHUK/IRF3/CASP10/NFKBIB/CXCL8/FADD/IKBKE/TRADD/TRAF6/MAPK10/MAPK13	19
KEGG	hsa05014	Amyotrophic lateral sclerosis	81/1542	364/8135	0.05978	0.1131	0.05861	NUP50/HDAC6/SRSF7/TNFRSF1A/RAB1A/MAP1LC3B/ATF4/TUBB2A/CHMP2B/CAT/TP53/CYC1/PINK1/GPX1/RB1CC1/GPX3/DDIT3/PFN1/PSMB4/TUBB/CASP3/UQCRC1/KIF5B/NDUFV1/NDUFS2/PSMB3/PSMD3/TANK/PSMD11/PFN2/PSMA1/GPX7/NDUFB1/SPG11/DCTN3/KIF5C/XBP1/ACTR1B/NDUFA2/MTOR/NDUFS7/MAPK14/FIG4/ITPR3/PPP3CC/HNRNPA1/SETX/NEFH/BAD/PSMD14/COX5A/CYCS/ATXN2L/UQCR11/ULK2/RAE1/PSMC6/COX7A2/ERBB4/PSMA3/TUBB2B/PSMC1/NXF1/TPR/ADRM1/WIPI2/PSMB1/SDHC/ATG2A/PSMA4/CCS/PSMC4/MAP2K3/NDUFC1/RAC1/NDUFS3/MAPK13/GPX2/PSMD13/SIGMAR1/PSMD8	81
KEGG	hsa04918	Thyroid hormone synthesis	20/1542	75/8135	0.06319	0.1188	0.0616	ATF4/ITPR2/CREB1/ADCY3/PLCB3/ATP1A1/GPX1/GPX3/ATP1B3/PLCB2/GPX7/GSR/GNAS/ASGR2/ITPR3/ADCY9/PRKACB/ASGR1/SLC5A5/GPX2	20
KEGG	hsa04217	Necroptosis	38/1542	159/8135	0.06916	0.1293	0.06704	TNFRSF1A/PYGL/TYK2/CHMP2B/SMPD1/IFNAR1/PYGB/SLC25A6/IFNAR2/TNFAIP3/IFNG/STAT2/BIRC3/HSP90AB1/NLRP3/STAT6/CAPN2/FAS/HSP90AA1/IFNA2/CFLAR/RBCK1/PARP1/CAPN1/TNFSF10/STAT1/ALOX15/AIFM1/FADD/FASLG/TRADD/FTH1/CAMK2G/CHMP7/FTL/MAPK10/PLA2G4A/STAT5A	38
KEGG	hsa04971	Gastric acid secretion	20/1542	76/8135	0.07109	0.1322	0.06853	EZR/GNAI2/SLC4A2/ITPR2/ADCY3/PLCB3/ATP1A1/ATP1B3/PLCB2/KCNQ1/GNAS/MYLK/GNAI1/ITPR3/ADCY9/PRKACB/KCNJ15/CAMK2G/KCNK2/KCNJ10	20
KEGG	hsa04931	Insulin resistance	27/1542	108/8135	0.07153	0.1323	0.06857	RPS6KA2/TNFRSF1A/PYGL/CREB1/AKT1/GFPT1/PIK3CD/PYGB/IKBKB/RPS6KB2/IRS1/MTOR/PRKCQ/PRKCD/SREBF1/PRKAA1/AKT2/SLC2A4/PIK3R2/PPP1CB/RPS6KA3/CD36/PRKAG1/PIK3CB/PPARA/MAPK10/SLC2A2	27
KEGG	hsa04725	Cholinergic synapse	28/1542	113/8135	0.0741	0.1363	0.07063	GNAI2/ATF4/MAPK3/ITPR2/CREB1/ADCY3/GNG7/GNG5/FYN/AKT1/PLCB3/PIK3CD/PLCB2/HRAS/KRAS/KCNQ1/GNB2/GNG12/GNAI1/ITPR3/ADCY9/MAP2K1/PRKACB/AKT2/PIK3R2/CAMK2G/PIK3CB/GNAO1	28
KEGG	hsa05144	Malaria	14/1542	50/8135	0.07726	0.1413	0.07324	IFNG/LRP1/THBS1/PECAM1/ITGB2/HGF/CXCL8/TGFB2/GYPC/CCL2/CD36/KLRB1/MET/ITGAL	14
KEGG	hsa04930	Type II diabetes mellitus	13/1542	46/8135	0.08141	0.1481	0.07675	HK2/MAPK3/PIK3CD/ADIPOQ/IKBKB/IRS1/MTOR/PRKCD/SLC2A4/PIK3R2/PIK3CB/MAPK10/SLC2A2	13
KEGG	hsa03450	Non-homologous end-joining	5/1542	13/8135	0.08186	0.1481	0.07675	PRKDC/XRCC5/XRCC6/LIG4/DNTT	5
KEGG	hsa04726	Serotonergic synapse	28/1542	115/8135	0.08872	0.1596	0.08273	GNAI2/MAPK3/ITPR2/GNG7/GNG5/PLCB3/CASP3/HTR2B/PLCB2/HRAS/PTGS2/KRAS/GNB2/ARAF/GNAS/GNG12/KCNJ9/GNAI1/ITPR3/ALOX5/MAP2K1/PRKACB/ALOX15/KCNJ5/CYP2C8/PLA2G4A/GNAO1/GABRB3	28
KEGG	hsa05330	Allograft rejection	11/1542	38/8135	0.09006	0.1611	0.08353	HLA-DMB/HLA-DMA/CD80/IFNG/FAS/HLA-DOB/HLA-DQB1/CD28/FASLG/HLA-A/GZMB	11
KEGG	hsa04371	Apelin signaling pathway	33/1542	139/8135	0.09209	0.1639	0.08495	SPP1/GNAI2/MAP1LC3B/MAPK3/ITPR2/ADCY3/GNG7/GNG5/AKT1/PLCB3/NOTCH3/MAP2K2/PLCB2/HRAS/SPHK2/KRAS/GNB2/RPS6KB2/MTOR/MYLK/GNG12/RRAS/GNAI1/ITPR3/ADCY9/CCND1/MAP2K1/MEF2A/PRKAA1/PRKACB/AKT2/NRF1/PRKAG1	33
KEGG	hsa04973	Carbohydrate digestion and absorption	13/1542	47/8135	0.09388	0.1662	0.08614	HK2/AKT1/PLCB3/ATP1A1/SLC2A5/PIK3CD/ATP1B3/PLCB2/SLC37A4/AKT2/PIK3R2/PIK3CB/SLC2A2	13
KEGG	hsa04024	cAMP signaling pathway	50/1542	221/8135	0.09463	0.1666	0.08637	VAV1/GNAI2/JUN/HCAR3/PLD2/MAPK3/CREBBP/CREB1/ADCY3/RAP1B/ATP2B4/AKT1/ATP1A1/ROCK1/PIK3CD/ATP1B3/NPY1R/ATP2A3/MAP2K2/ATP2B1/PDE4D/PLD1/PLN/GNAS/RHOA/PTGER3/RRAS/GNAI1/FSHB/ADCY9/BAD/MAP2K1/GCG/PRKACB/ADCYAP1/AKT2/PIK3R2/PPP1CB/CAMK2G/PIK3CB/EDNRA/ACOX1/PPARA/MAPK10/ROCK2/NPY/PTGER2/RAC1/PPP1R12A/F2R	50
KEGG	hsa00790	Folate biosynthesis	8/1542	26/8135	0.1028	0.1793	0.09292	PCBD1/FPGS/CBR1/QDPR/AKR1B1/PTS/GCH1/DHFR	8
KEGG	hsa05415	Diabetic cardiomyopathy	46/1542	203/8135	0.1032	0.1793	0.09292	NCF4/CYC1/AKT1/PLCB3/GFPT1/PIK3CD/UQCRC1/SLC25A6/NDUFV1/MMP9/ATP2A3/NDUFS2/PLCB2/ACE/PPIF/CTSD/NDUFB1/NDUFA2/PLN/GSR/IRS1/MTOR/NDUFS7/MAPK14/PRKCD/COX5A/PARP1/UQCR11/COX7A2/TGFB2/AKT2/PDK2/SLC2A4/PIK3R2/PPP1CB/CAMK2G/PDHB/CD36/SDHC/PIK3CB/PPARA/NDUFC1/MAPK10/RAC1/NDUFS3/MAPK13	46
KEGG	hsa04114	Oocyte meiosis	31/1542	131/8135	0.1034	0.1793	0.09292	IGF1/RPS6KA2/YWHAQ/MAPK3/ITPR2/ADCY3/PPP2R1A/ANAPC15/PTTG1/ESPL1/ANAPC13/ANAPC5/MAD2L1/MAPK14/CDK2/ITPR3/PPP3CC/ADCY9/CDC16/MAP2K1/PRKACB/CUL1/PPP2R5D/PPP1CB/CAMK2G/RPS6KA3/YWHAH/YWHAB/CCNB1/CDK1/MAPK13	31
KEGG	hsa00511	Other glycan degradation	6/1542	18/8135	0.1084	0.1869	0.09691	MAN2B1/FUCA1/MAN2C1/HEXA/NEU1/MAN2B2	6
KEGG	hsa04962	Vasopressin-regulated water reabsorption	12/1542	44/8135	0.1141	0.1957	0.1015	RAB5C/ARHGDIA/RAB11B/CREB1/ADCY3/DYNC1LI2/GNAS/ADCY9/PRKACB/DYNC1H1/VAMP2/ARHGDIB	12
KEGG	hsa00052	Galactose metabolism	9/1542	31/8135	0.1169	0.1984	0.1029	GAA/GLA/HK2/PFKP/PFKL/GALK1/AKR1B1/PFKM/GALE	9
KEGG	hsa04710	Circadian rhythm	9/1542	31/8135	0.1169	0.1984	0.1029	BHLHE40/CREB1/PER2/CRY1/PRKAA1/CUL1/PRKAG1/ARNTL/RORA	9
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	13/1542	49/8135	0.1221	0.2046	0.1061	RENBP/HK2/GNPDA1/GFPT1/TSTA3/MPI/GALK1/FPGT/CYB5R1/GALE/HEXA/PMM1/UAP1	13
KEGG	hsa04672	Intestinal immune network for IgA production	13/1542	49/8135	0.1221	0.2046	0.1061	HLA-DMB/ITGB7/HLA-DMA/LTBR/CD80/MAP3K14/IL15/HLA-DOB/HLA-DQB1/ICOS/MADCAM1/CD28/CXCL12	13
KEGG	hsa04022	cGMP-PKG signaling pathway	38/1542	167/8135	0.123	0.2046	0.1061	ADORA3/GNAI2/ATF4/MAPK3/ITPR2/CREB1/ADCY3/ATP2B4/AKT1/PLCB3/ATP1A1/ROCK1/SLC25A6/ATP1B3/ATP2A3/MAP2K2/ATP2B1/PLCB2/PPIF/PLN/IRS1/RHOA/MYLK/SRF/GNAI1/ITPR3/PPP3CC/ADCY9/BAD/GNA12/MAP2K1/MEF2A/AKT2/RGS2/PPP1CB/EDNRA/ROCK2/PPP1R12A	38
KEGG	hsa00062	Fatty acid elongation	8/1542	27/8135	0.123	0.2046	0.1061	TECR/HADHA/HADH/HADHB/ELOVL2/ECHS1/PPT1/ELOVL5	8
KEGG	hsa04270	Vascular smooth muscle contraction	31/1542	134/8135	0.1296	0.2144	0.1111	PTGIR/ADORA2B/MAPK3/ITPR2/ADCY3/ARHGEF11/PLCB3/ROCK1/ADM/MAP2K2/PLCB2/ARAF/GNAS/RHOA/MYLK/PRKCQ/PRKCD/ITPR3/CALCRL/ADCY9/GNA12/MAP2K1/PRKACB/MYL6B/MYH9/PPP1CB/EDNRA/ROCK2/PRKCH/PLA2G4A/PPP1R12A	31
KEGG	hsa04215	Apoptosis - multiple species	9/1542	32/8135	0.1367	0.2251	0.1167	TNFRSF1A/CASP3/PMAIP1/BIRC3/BAK1/CYCS/CASP7/FADD/MAPK10	9
KEGG	hsa04979	Cholesterol metabolism	13/1542	50/8135	0.1379	0.226	0.1171	NPC1/PLTP/LRP1/APOH/SCARB1/VAPA/LRPAP1/NPC2/STARD3/LPL/CYP27A1/CD36/SORT1	13
KEGG	hsa04934	Cushing syndrome	35/1542	155/8135	0.1451	0.2366	0.1226	GNAI2/ATF4/CDKN1A/MAPK3/ITPR2/CREB1/ADCY3/RAP1B/PLCB3/FZD2/ARNT/MAP2K2/PLCB2/SCARB1/GNAS/FZD7/GNAI1/CDK2/ITPR3/CDK4/ADCY9/CCND1/RB1/CTNNB1/MAP2K1/PRKACB/CDKN2A/AIP/MEN1/NR4A1/DVL3/CAMK2G/FZD5/KCNK2/FZD6	35
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	10/1542	37/8135	0.1481	0.2403	0.1245	IGF1/MAPK3/ATP1A1/PIK3CD/ATP1B3/KRAS/IRS1/NEDD4L/PIK3R2/PIK3CB	10
KEGG	hsa04925	Aldosterone synthesis and secretion	23/1542	98/8135	0.1544	0.2486	0.1289	CAMK1/ATF4/ITPR2/CREB1/NR4A2/ADCY3/ATP2B4/PLCB3/ATP1A1/ATP1B3/ATP2B1/PLCB2/SCARB1/PRKD2/GNAS/ITPR3/ADCY9/PRKACB/NR4A1/KCNJ5/CAMK2G/PRKD1/PRKD3	23
KEGG	hsa04913	Ovarian steroidogenesis	13/1542	51/8135	0.1547	0.2486	0.1289	IGF1/CYP1A1/ADCY3/SCARB1/PTGS2/GNAS/BMP6/FSHB/ALOX5/ADCY9/PRKACB/CYP1B1/PLA2G4A	13
KEGG	hsa05332	Graft-versus-host disease	11/1542	42/8135	0.1576	0.252	0.1306	HLA-DMB/HLA-DMA/CD80/IFNG/FAS/HLA-DOB/HLA-DQB1/CD28/FASLG/HLA-A/GZMB	11
KEGG	hsa00670	One carbon pool by folate	6/1542	20/8135	0.1627	0.259	0.1342	MTHFD2/GART/ATIC/MTHFD1/DHFR/MTHFR	6
KEGG	hsa00590	Arachidonic acid metabolism	15/1542	61/8135	0.1668	0.2641	0.1369	TBXAS1/GPX1/GPX3/PTGS2/GPX7/CBR1/LTC4S/ALOX5/ALOX15/CYP2C8/PTGES/CYP4F2/PLA2G4A/PTGES3/GPX2	15
KEGG	hsa04724	Glutamatergic synapse	26/1542	114/8135	0.1736	0.2736	0.1418	GNAI2/PLD2/MAPK3/ITPR2/ADCY3/GNG7/GNG5/PLCB3/PLCB2/PLD1/GNB2/GLS/GNAS/HOMER3/GNG12/GNAI1/ITPR3/PPP3CC/ADCY9/PRKACB/HOMER1/DLG4/PLA2G4A/SLC1A3/GNAO1/SLC1A1	26
KEGG	hsa00770	Pantothenate and CoA biosynthesis	6/1542	21/8135	0.1935	0.3024	0.1568	BCAT1/ALDH3A2/VNN2/DPYD/ENPP1/AASDHPPT	6
KEGG	hsa04916	Melanogenesis	23/1542	101/8135	0.1937	0.3024	0.1568	GNAI2/MAPK3/CREBBP/CREB1/ADCY3/PLCB3/FZD2/MAP2K2/PLCB2/HRAS/KRAS/GNAS/FZD7/GNAI1/ADCY9/CTNNB1/MAP2K1/PRKACB/DVL3/CAMK2G/FZD5/FZD6/GNAO1	23
KEGG	hsa04310	Wnt signaling pathway	36/1542	167/8135	0.2191	0.3405	0.1765	CCND2/JUN/CREBBP/TP53/PLCB3/TBL1X/CSNK1A1/CTNNBIP1/PPARD/FZD2/PLCB2/RHOA/FZD7/CTBP1/PPP3CC/GPC4/CCND1/TLE1/DAAM1/CTNNB1/PRKACB/CUL1/INVS/CBY1/PRICKLE3/CSNK2A1/DVL3/CAMK2G/FZD5/RYK/FZD6/MAPK10/ROCK2/CTNND2/RAC1/LRP6	36
KEGG	hsa00900	Terpenoid backbone biosynthesis	6/1542	22/8135	0.2262	0.3492	0.181	MVD/FNTA/PMVK/FDPS/HMGCS2/ICMT	6
KEGG	hsa00510	N-Glycan biosynthesis	12/1542	50/8135	0.2268	0.3492	0.181	GANAB/MGAT5/MGAT2/MOGS/DPM1/DOLK/ALG3/STT3A/DDOST/MAN2A1/RPN1/MAN2A2	12
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	7/1542	27/8135	0.2398	0.3674	0.1905	TECR/SCD/HSD17B4/FADS2/ELOVL2/ELOVL5/ACOX1	7
KEGG	hsa00270	Cysteine and methionine metabolism	12/1542	51/8135	0.249	0.3794	0.1966	LDHA/DNMT1/AHCY/MPST/MAT2A/BCAT1/SMS/CTH/TST/AMD1/GCLM/LDHC	12
KEGG	hsa04136	Autophagy - other	8/1542	32/8135	0.2499	0.3794	0.1966	GABARAP/ATG12/GABARAPL1/MTOR/ULK2/GABARAPL2/WIPI2/ATG2A	8
KEGG	hsa00561	Glycerolipid metabolism	14/1542	61/8135	0.2562	0.3873	0.2007	GK/DGKZ/GLA/AGPAT1/ALDH3A2/DGAT1/ALDH9A1/ALDH7A1/LPL/AKR1B1/MGLL/DGKD/DGKQ/AKR1A1	14
KEGG	hsa01250	Biosynthesis of nucleotide sugars	9/1542	37/8135	0.2575	0.3875	0.2008	HK2/GFPT1/TSTA3/MPI/GALK1/FPGT/GALE/PMM1/UAP1	9
KEGG	hsa00650	Butanoate metabolism	7/1542	28/8135	0.2713	0.4064	0.2107	HADHA/HADH/ACADS/BDH1/ECHS1/HMGCS2/HMGCL	7
KEGG	hsa00531	Glycosaminoglycan degradation	5/1542	19/8135	0.2845	0.4226	0.2191	NAGLU/SGSH/HEXA/IDS/HYAL2	5
KEGG	hsa04713	Circadian entrainment	21/1542	97/8135	0.2847	0.4226	0.2191	GNAI2/MAPK3/CREB1/ADCY3/GNG7/GNG5/PLCB3/PLCB2/PER2/GNB2/GNAS/GNG12/KCNJ9/GNAI1/ITPR3/ADCY9/PRKACB/ADCYAP1/KCNJ5/CAMK2G/GNAO1	21
KEGG	hsa00860	Porphyrin metabolism	10/1542	43/8135	0.2895	0.4272	0.2215	BLVRB/UROS/PPOX/CP/BLVRA/HMOX1/HEPH/HCCS/ALAD/UROD	10
KEGG	hsa04060	Cytokine-cytokine receptor interaction	60/1542	295/8135	0.2904	0.4272	0.2215	CD4/CSF1R/TNFRSF1A/CXCL9/IL1R2/IL10RA/IFNAR1/IL2RG/TNFRSF14/LTBR/TNFSF14/IFNAR2/OSMR/IFNG/CCL7/IL3RA/CCR7/IL1RAP/IL1RN/TNFRSF21/IL15/CCL20/ACVR1/PPBP/FAS/IL24/BMP6/IL32/CCR5/IL2RB/IL12RB1/IFNA2/CSF3R/IL1R1/GHR/TNFSF11/IL13RA1/CSF2/TNFSF10/BMP5/CCR6/TNFSF8/CXCL8/CD27/INHBA/TGFB2/CXCR6/FASLG/CCL2/CCL16/CCR4/CXCL13/XCL1/CXCL12/IL1RL1/CCL3/GH1/IL27RA/TNFRSF11A/CSF1	60
KEGG	hsa04723	Retrograde endocannabinoid signaling	31/1542	148/8135	0.297	0.4339	0.2249	GNAI2/MAPK3/ITPR2/ADCY3/GNG7/GNG5/PLCB3/NDUFV1/NDUFS2/PLCB2/PTGS2/GNB2/NDUFB1/NDUFA2/NDUFS7/GNG12/MAPK14/KCNJ9/GNAI1/ITPR3/ADCY9/MGLL/PRKACB/KCNJ5/GABRG2/NDUFC1/MAPK10/NDUFS3/GNAO1/MAPK13/GABRB3	31
KEGG	hsa00480	Glutathione metabolism	13/1542	58/8135	0.2975	0.4339	0.2249	GSTP1/IDH2/GPX1/GPX3/SMS/MGST2/GPX7/GSTO1/GSR/IDH1/ANPEP/GCLM/GPX2	13
KEGG	hsa00310	Lysine degradation	14/1542	63/8135	0.2991	0.4342	0.2251	HADHA/GCDH/HADH/EHMT2/EZH1/ALDH3A2/SETDB1/ALDH9A1/ALDH7A1/KMT2B/ECHS1/COLGALT2/AASS/PLOD2	14
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1542	15/8135	0.3129	0.4522	0.2344	ST3GAL1/HEXA/SLC33A1/B3GALT4	4
KEGG	hsa04350	TGF-beta signaling pathway	20/1542	94/8135	0.3205	0.4612	0.2391	TGIF1/MAPK3/CREBBP/PPP2R1A/ROCK1/ID1/IFNG/E2F4/THBS1/ACVR1/ZFYVE16/BMP6/RPS6KB2/RHOA/BMP5/ID3/INHBA/CUL1/TGFB2/ID2	20
KEGG	hsa00100	Steroid biosynthesis	5/1542	20/8135	0.325	0.4658	0.2414	TM7SF2/FDFT1/NSDHL/CYP24A1/CYP27B1	5
KEGG	hsa02010	ABC transporters	10/1542	45/8135	0.3434	0.4899	0.2539	ABCA6/ABCD1/ABCC1/ABCB7/TAP1/ABCG2/DEFB1/ABCC5/ABCG1/ABCB9	10
KEGG	hsa04520	Adherens junction	15/1542	71/8135	0.3653	0.5189	0.269	MAPK3/CREBBP/FYN/WAS/CDC42/YES1/RHOA/SSX2IP/CTNNB1/CSNK2A1/FGFR1/ACTN4/PTPRJ/MET/RAC1	15
KEGG	hsa00330	Arginine and proline metabolism	11/1542	51/8135	0.3701	0.5232	0.2712	GATM/P4HA1/OAT/SMS/ALDH3A2/PRODH/ALDH9A1/ALDH7A1/CKM/AMD1/LOC102724788	11
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	8/1542	36/8135	0.3715	0.5232	0.2712	NAMPT/PNP/BST1/NNT/NADK/ENPP1/NMNAT2/NT5C2	8
KEGG	hsa04972	Pancreatic secretion	21/1542	102/8135	0.3746	0.5255	0.2724	SLC4A2/ITPR2/ADCY3/RAP1B/ATP2B4/PLCB3/ATP1A1/ATP1B3/ATP2A3/ATP2B1/PLCB2/CPB2/KCNQ1/SLC12A2/GNAS/RHOA/ITPR3/ADCY9/BST1/CELA2B/RAC1	21
KEGG	hsa04714	Thermogenesis	46/1542	232/8135	0.3919	0.5473	0.2837	RPS6KA2/TSC2/RHEB/CREB1/PPARG/ADCY3/CYC1/UQCRC1/SMARCC2/NDUFV1/NDUFAF1/NDUFS2/HRAS/KRAS/NDUFB1/ZNF516/NDUFA2/SOS1/GNAS/RPS6KB2/MTOR/NDUFS7/ACTL6A/MAPK14/GRB2/ADCY9/SMARCD2/COX5A/MGLL/GCG/UQCR11/PRKAA1/PRKACB/COX7A2/KDM3B/NDUFAF3/ARID1A/FGFR1/RPS6KA3/SDHC/PRKAG1/MAP2K3/NDUFC1/NDUFS3/MAPK13/KDM1A	46
KEGG	hsa00600	Sphingolipid metabolism	11/1542	52/8135	0.3964	0.5513	0.2858	GLA/SMPD1/ARSA/ASAH1/SPHK2/GALC/KDSR/PSAP/HEXA/NEU1/UGCG	11
KEGG	hsa00340	Histidine metabolism	5/1542	22/8135	0.4073	0.5641	0.2924	HNMT/ALDH3B1/ALDH3A2/ALDH9A1/ALDH7A1	5
KEGG	hsa04360	Axon guidance	36/1542	182/8135	0.4169	0.575	0.2981	EPHB2/GNAI2/ILK/MAPK3/PLXNC1/FYN/CFL1/ROCK1/ITGB1/PIK3CD/ABL1/EPHB6/FES/PLXNB2/HRAS/PTK2/KRAS/CDC42/RHOA/RRAS/EPHA7/GNAI1/PPP3CC/ROBO1/PIK3R2/CAMK2G/PIK3CB/SEMA3C/RYK/CXCL12/EPHA4/MET/ROCK2/ABLIM1/RAC1/MYL12B	36
KEGG	hsa05320	Autoimmune thyroid disease	11/1542	53/8135	0.4229	0.5808	0.3011	HLA-DMB/HLA-DMA/CD80/FAS/HLA-DOB/IFNA2/HLA-DQB1/CD28/FASLG/HLA-A/GZMB	11
KEGG	hsa04924	Renin secretion	14/1542	69/8135	0.4361	0.5965	0.3092	GNAI2/ITPR2/CREB1/PLCB3/PLCB2/ACE/GNAS/GNAI1/ITPR3/PPP3CC/PRKACB/ADCYAP1/EDNRA/PTGER2	14
KEGG	hsa04614	Renin-angiotensin system	5/1542	23/8135	0.4481	0.6104	0.3164	CTSA/ACE/PREP/ANPEP/MME	5
KEGG	hsa04927	Cortisol synthesis and secretion	13/1542	65/8135	0.4644	0.6257	0.3244	ATF4/ITPR2/CREB1/ADCY3/PLCB3/PLCB2/SCARB1/GNAS/ITPR3/ADCY9/PRKACB/NR4A1/KCNK2	13
KEGG	hsa05321	Inflammatory bowel disease	13/1542	65/8135	0.4644	0.6257	0.3244	HLA-DMB/JUN/HLA-DMA/IL2RG/TLR5/IFNG/STAT6/HLA-DOB/IL12RB1/STAT1/HLA-DQB1/TGFB2/RORA	13
KEGG	hsa00513	Various types of N-glycan biosynthesis	8/1542	39/8135	0.4655	0.6257	0.3244	MGAT2/ALG3/HEXA/STT3A/DDOST/MAN2A1/RPN1/MAN2A2	8
KEGG	hsa04911	Insulin secretion	17/1542	86/8135	0.4669	0.6257	0.3244	ATF4/CREB1/ADCY3/PLCB3/ATP1A1/ATP1B3/PLCB2/GNAS/ITPR3/ADCY9/GCG/PRKACB/ADCYAP1/VAMP2/CAMK2G/KCNN4/SLC2A2	17
KEGG	hsa00190	Oxidative phosphorylation	26/1542	134/8135	0.4822	0.6436	0.3336	ATP6V0A1/ATP6V0C/CYC1/TCIRG1/UQCRC1/NDUFV1/NDUFS2/ATP6V1A/NDUFB1/ATP6AP1/NDUFA2/NDUFS7/ATP6V1B2/ATP6V1G1/COX5A/CYCS/ATP6V1H/UQCR11/ATP6V1D/ATP6V1E1/COX7A2/SDHC/ATP6V0E2/NDUFC1/NDUFS3/ATP6V0D1	26
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	29/1542	150/8135	0.486	0.646	0.3349	GNAI2/ATF4/MAPK3/CREB1/ADCY3/ATP2B4/AKT1/PPP2R1A/PLCB3/ATP1A1/PPP2R2A/ATP1B3/ATP2A3/ATP2B1/PLCB2/KCNQ1/PLN/GNAS/MAPK14/GNAI1/ADCY9/TPM4/PRKACB/CREM/AKT2/PPP2R5D/PPP1CB/CAMK2G/MAPK13	29
KEGG	hsa04146	Peroxisome	16/1542	82/8135	0.4933	0.6531	0.3386	IDH2/CAT/PEX11B/ABCD1/MPV17/HSD17B4/ECH1/PMVK/PEX6/IDH1/ACOT8/PEX10/PEX7/ACOX1/CRAT/HMGCL	16
KEGG	hsa00564	Glycerophospholipid metabolism	19/1542	98/8135	0.4973	0.6558	0.34	PLD3/CDS1/DGKZ/PLD2/AGPAT1/PLD1/PLA2G15/CHKB/PEMT/PNPLA6/CDIPT/DGKD/GPD1L/DGKQ/GPD2/LPCAT1/MBOAT7/LYPLA2/PLA2G4A	19
KEGG	hsa04970	Salivary secretion	18/1542	93/8135	0.5028	0.6604	0.3423	CST3/SLC4A2/ITPR2/ADCY3/ATP2B4/PLCB3/ATP1A1/ATP1B3/ATP2B1/PLCB2/SLC12A2/GNAS/ITPR3/ADCY9/BST1/PRKACB/VAMP2/KCNN4	18
KEGG	hsa04512	ECM-receptor interaction	17/1542	88/8135	0.5085	0.6653	0.3449	SPP1/ITGB7/AGRN/LAMB2/ITGB1/ITGB5/FN1/ITGA7/COL4A1/LAMC1/THBS1/ITGA1/CD44/LAMA2/CD36/ITGB8/COL4A4	17
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1542	30/8135	0.5151	0.6712	0.3479	CAT/ACO2/ACO1/GRHPR/PCCB/PCCA	6
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/1542	78/8135	0.5211	0.6765	0.3507	EPHX1/GSTP1/AKR7A2/CYP1A1/ALDH3B1/MGST2/AKR7A3/GSTO1/CBR1/CYP1B1/SULT2A1/HSD11B1/ADH1B/ADH5/CYP2A6	15
KEGG	hsa00240	Pyrimidine metabolism	11/1542	58/8135	0.5524	0.7143	0.3703	ASMTL/NME3/ENTPD6/UPP1/NME4/CAD/DPYD/ENPP1/DUT/UCKL1/NT5C2	11
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	13/1542	69/8135	0.5586	0.7195	0.373	EPHX1/GSTP1/CYP1A1/SULT1A1/PTGS2/MGST2/GSTO1/CBR1/CYP1B1/SULT2A1/HSD11B1/CYP2C8/CYP2A6	13
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1542	15/8135	0.5619	0.7209	0.3737	GLA/ST3GAL1/HEXA	3
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1542	26/8135	0.5646	0.7216	0.374	MPPE1/GPAA1/PIGQ/PIGF/PIGL	5
KEGG	hsa05032	Morphine addiction	17/1542	91/8135	0.5694	0.7249	0.3758	GNAI2/ARRB2/ADCY3/GNG7/GNG5/PDE4D/GNB2/GNAS/GNG12/KCNJ9/GNAI1/ADCY9/PRKACB/KCNJ5/GABRG2/GNAO1/GABRB3	17
KEGG	hsa03015	mRNA surveillance pathway	18/1542	97/8135	0.5814	0.7374	0.3822	PAPOLA/CSTF2T/PPP2R1A/PPP2R2A/EIF4A3/CSTF2/UPF1/CPSF4/DDX19B/HBS1L/SMG5/SYMPK/SAP18/NXF1/PPP2R5D/PPP1CB/GSPT1/MSI1	18
KEGG	hsa03460	Fanconi anemia pathway	10/1542	54/8135	0.5878	0.7426	0.3849	HES1/RPA1/ERCC4/REV3L/BLM/ERCC1/FANCL/FANCA/RAD51/ATR	10
KEGG	hsa04390	Hippo signaling pathway	29/1542	157/8135	0.5947	0.7484	0.388	CCND2/YWHAQ/TP53BP2/PPP2R1A/PPP2R2A/ID1/FZD2/BIRC3/AREG/BMP6/ITGB2/SCRIB/FZD7/PRKCI/CCND1/FGF1/CTNNB1/BMP5/TGFB2/ID2/AFP/DVL3/DLG4/PPP1CB/FZD5/YWHAH/FZD6/YWHAB/NF2	29
KEGG	hsa05030	Cocaine addiction	9/1542	49/8135	0.5996	0.7518	0.3897	GNAI2/JUN/ATF4/CREB1/GNAS/GNAI1/RGS9/PRKACB/DLG4	9
KEGG	hsa00430	Taurine and hypotaurine metabolism	3/1542	16/8135	0.6085	0.7601	0.394	ADO/FMO5/FMO3	3
KEGG	hsa04020	Calcium signaling pathway	44/1542	240/8135	0.6249	0.7761	0.4023	FLT1/CAMK1/ADORA2B/VEGFB/ITPR2/HRH1/ADCY3/ATP2B4/PLCB3/VEGFA/PHKB/SLC25A6/HTR2B/ORAI2/ATP2A3/ATP2B1/PLCB2/SPHK2/PPIF/PLN/P2RX1/GNAS/PTGER3/MYLK/PDGFB/HGF/PTAFR/ITPR3/PPP3CC/FGF9/PDGFA/ADCY9/PHKG2/FGF1/STIM1/PRKACB/ERBB4/PHKA2/FGFR1/CAMK2G/FGF7/EDNRA/MET/F2R	44
KEGG	hsa05206	MicroRNAs in cancer	57/1542	310/8135	0.626	0.7761	0.4023	CCND2/EZR/ATM/CDKN1A/SPRY2/DNMT1/MAPK3/CREBBP/PIM1/TP53/MCL1/ROCK1/VEGFA/PIK3CD/ABL1/CASP3/DDIT4/ABCC1/NOTCH3/MARCKS/MMP9/MAP2K2/NOTCH2/VIM/HDAC1/THBS1/HRAS/PTGS2/KRAS/IKBKB/SOS1/GLS/IRS1/MTOR/RHOA/BAK1/PDGFB/HMOX1/GRB2/PDGFA/TP63/CCND1/RDX/MAP2K1/CYP1B1/CD44/CDKN2A/TGFB2/SLC7A1/MAPK7/PIK3R2/CYP24A1/MDM4/PIK3CB/CDC25B/MET/HNRNPK	57
KEGG	hsa04727	GABAergic synapse	16/1542	89/8135	0.6361	0.7837	0.4063	GABARAP/GNAI2/ADCY3/GNG7/GNG5/GABARAPL1/GNB2/GLS/GNG12/GNAI1/ADCY9/PRKACB/GABARAPL2/GABRG2/GNAO1/GABRB3	16
KEGG	hsa04340	Hedgehog signaling pathway	10/1542	56/8135	0.6369	0.7837	0.4063	CCND2/ARRB2/MEGF8/CSNK1A1/CSNK1G2/IQCE/CCND1/PRKACB/CUL1/MGRN1	10
KEGG	hsa03020	RNA polymerase	6/1542	34/8135	0.6459	0.7919	0.4105	POLR2L/POLR2E/POLR2A/POLR2I/POLR2J/POLR3C	6
KEGG	hsa00120	Primary bile acid biosynthesis	3/1542	17/8135	0.6517	0.796	0.4126	HSD17B4/CYP27A1/ACOT8	3
KEGG	hsa03060	Protein export	4/1542	23/8135	0.6592	0.797	0.4132	SEC11A/SEC62/OXA1L/SEC61G	4
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	4/1542	23/8135	0.6592	0.797	0.4132	ATP1A1/ATP1B3/GLS/SLC9A3	4
KEGG	hsa05150	Staphylococcus aureus infection	17/1542	96/8135	0.6637	0.797	0.4132	HLA-DMB/ITGAM/HLA-DMA/FCGR3A/C5/HLA-DOB/ITGB2/FPR2/DEFB1/PTAFR/FCAR/CFD/HLA-DQB1/FGG/CFI/ITGAL/C1R	17
KEGG	hsa05414	Dilated cardiomyopathy	17/1542	96/8135	0.6637	0.797	0.4132	IGF1/ITGB7/ADCY3/ITGB1/ITGB5/ATP2A3/ITGA7/PLN/GNAS/ITGA1/ADCY9/TPM4/PRKACB/LMNA/TGFB2/LAMA2/ITGB8	17
KEGG	hsa01232	Nucleotide metabolism	15/1542	85/8135	0.6646	0.797	0.4132	ASMTL/NME3/ENTPD6/UPP1/IMPDH1/ADA/APRT/NME4/PNP/ADK/ENPP1/DUT/DGUOK/UCKL1/NT5C2	15
KEGG	hsa04623	Cytosolic DNA-sensing pathway	11/1542	63/8135	0.6694	0.797	0.4132	POLR2L/IKBKB/POLR2E/IFNA2/ADAR/CHUK/IRF3/NFKBIB/AIM2/IKBKE/POLR3C	11
KEGG	hsa05217	Basal cell carcinoma	11/1542	63/8135	0.6694	0.797	0.4132	CDKN1A/TP53/FZD2/GADD45A/BAK1/FZD7/GADD45B/CTNNB1/DVL3/FZD5/FZD6	11
KEGG	hsa03013	Nucleocytoplasmic transport	19/1542	108/8135	0.68	0.8067	0.4182	NUP50/RANGAP1/EIF4A3/SUMO1/UPF1/KPNA2/DDX19B/EEF1A2/SNUPN/TNPO1/RAE1/IPO13/RAN/SAP18/NXF1/KPNA3/TPR/XPOT/SUMO3	19
KEGG	hsa03440	Homologous recombination	7/1542	41/8135	0.6828	0.8072	0.4184	ATM/RPA1/RAD52/BLM/POLD1/POLD4/RAD51	7
KEGG	hsa03010	Ribosome	28/1542	158/8135	0.6866	0.8088	0.4193	RPS15A/RPL36AL/RPL24/RPL9/RPS25/RPL31/RPS19/RPL7/FAU/RPS21/MRPL28/RPL6/RPS29/MRPS12/RPL34/MRPL9/MRPL23/RPS27A/RPL13/RPS15/RPS7/RPS16/RPL22/RPL37/RPL38/RPL11/RPS4Y1/RPL14	28
KEGG	hsa00061	Fatty acid biosynthesis	3/1542	18/8135	0.6913	0.8109	0.4204	FASN/HSD17B8/CBR4	3
KEGG	hsa01240	Biosynthesis of cofactors	27/1542	153/8135	0.6933	0.8109	0.4204	MTHFD2/UROS/NME3/LIPT1/FLAD1/MAT2A/BCAT1/FPGS/MPI/ALDH3A2/PPOX/NME4/KYNU/MTHFD1/CAD/PMM1/NADK/PTS/NMNAT2/GCH1/DHFR/GCLM/AKR1A1/IDO1/ALAD/HAAO/UROD	27
KEGG	hsa00030	Pentose phosphate pathway	5/1542	30/8135	0.6976	0.813	0.4214	FBP1/TKT/PFKP/PFKL/PFKM	5
KEGG	hsa00350	Tyrosine metabolism	6/1542	36/8135	0.7026	0.8161	0.423	MIF/COMT/ALDH3B1/GSTZ1/ADH1B/ADH5	6
KEGG	hsa04514	Cell adhesion molecules	26/1542	149/8135	0.7137	0.826	0.4282	CD4/HLA-DMB/ITGB7/VCAN/CD99/ITGAM/HLA-DMA/ITGB1/CD2/CD80/ALCAM/PECAM1/HLA-DOB/ITGB2/ICAM2/HLA-DQB1/ICOS/CD22/MADCAM1/CD28/SDC3/ICAM3/PVR/ITGB8/HLA-A/ITGAL	26
KEGG	hsa05143	African trypanosomiasis	6/1542	37/8135	0.7286	0.8403	0.4356	PLCB3/IFNG/PLCB2/FAS/FASLG/IDO1	6
KEGG	hsa05410	Hypertrophic cardiomyopathy	15/1542	90/8135	0.7509	0.8631	0.4474	IGF1/ITGB7/ITGB1/ITGB5/ATP2A3/ITGA7/ACE/ITGA1/TPM4/PRKAA1/LMNA/TGFB2/LAMA2/PRKAG1/ITGB8	15
KEGG	hsa04950	Maturity onset diabetes of the young	4/1542	26/8135	0.7543	0.8639	0.4478	HES1/HHEX/FOXA2/SLC2A2	4
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1542	20/8135	0.7602	0.8676	0.4497	CHSY1/CHST15/B3GAT3	3
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1542	14/8135	0.7748	0.8813	0.4568	ST3GAL1/CHST1	2
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1542	27/8135	0.781	0.8853	0.4589	FUT3/ST3GAL6/B3GALT2/B3GNT3	4
KEGG	hsa00260	Glycine, serine and threonine metabolism	6/1542	40/8135	0.7966	0.8999	0.4665	GATM/PGAM1/CTH/ALDH7A1/GRHPR/PSPH	6
KEGG	hsa04976	Bile secretion	14/1542	89/8135	0.8192	0.9223	0.4781	EPHX1/AQP9/SLC4A2/ADCY3/ATP1A1/ATP1B3/RXRA/SCARB1/ABCG2/GNAS/ADCY9/PRKACB/SULT2A1/SLC9A3	14
KEGG	hsa00360	Phenylalanine metabolism	2/1542	16/8135	0.836	0.9354	0.4849	MIF/ALDH3B1	2
KEGG	hsa00500	Starch and sucrose metabolism	5/1542	36/8135	0.8393	0.9354	0.4849	GAA/PYGL/HK2/PYGB/ENPP1	5
KEGG	hsa00512	Mucin type O-glycan biosynthesis	5/1542	36/8135	0.8393	0.9354	0.4849	ST3GAL1/GALNT3/GALNT2/GCNT1/B3GNT3	5
KEGG	hsa00565	Ether lipid metabolism	7/1542	49/8135	0.8468	0.9382	0.4863	PLD3/PLD2/PAFAH1B2/PLD1/PLA2G7/LPCAT1/PLA2G4A	7
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/1542	30/8135	0.8475	0.9382	0.4863	ALDH3A2/ALDH9A1/ALDH7A1/AKR1A1	4
KEGG	hsa00983	Drug metabolism - other enzymes	12/1542	80/8135	0.8543	0.9412	0.4879	GSTP1/NME3/UPP1/IMPDH1/MGST2/NME4/GSTO1/DPYD/DUT/CES2/CYP2A6/UCKL1	12
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	5/1542	37/8135	0.8566	0.9412	0.4879	ASNS/GFPT1/GLS/CAD/ASL	5
KEGG	hsa04977	Vitamin digestion and absorption	3/1542	24/8135	0.8604	0.9412	0.4879	BTD/ABCC1/SCARB1	3
KEGG	hsa00230	Purine metabolism	20/1542	128/8135	0.8616	0.9412	0.4879	NME3/ENTPD6/ADCY3/PAPSS1/PFAS/IMPDH1/PDE4D/GART/ADA/APRT/NME4/PNP/ADK/PAPSS2/ATIC/PDE6G/ADCY9/ENPP1/DGUOK/NT5C2	20
KEGG	hsa05310	Asthma	4/1542	31/8135	0.8654	0.9412	0.4879	HLA-DMB/HLA-DMA/HLA-DOB/HLA-DQB1	4
KEGG	hsa05031	Amphetamine addiction	10/1542	69/8135	0.8672	0.9412	0.4879	JUN/ATF4/CREB1/ARC/HDAC1/GNAS/PPP3CC/PRKACB/PPP1CB/CAMK2G	10
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1542	25/8135	0.8788	0.9506	0.4928	FADS2/ACOX1/PLA2G4A	3
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1542	77/8135	0.8874	0.9568	0.496	ITGB7/ITGB1/ITGB5/ATP2A3/ITGA7/ITGA1/CTNNB1/LMNA/JUP/LAMA2/ITGB8	11
KEGG	hsa04613	Neutrophil extracellular trap formation	30/1542	190/8135	0.8908	0.9573	0.4962	NCF4/AQP9/HDAC6/MAPK3/ITGAM/AKT1/PLCB3/FCGR3A/PIK3CD/CASP4/AZU1/SLC25A6/C5/MAP2K2/PLCB2/HDAC1/PPIF/SYK/MTOR/ITGB2/FPR2/MAPK14/MAP2K1/FGG/AKT2/PIK3R2/PIK3CB/ITGAL/RAC1/MAPK13	30
KEGG	hsa00982	Drug metabolism - cytochrome P450	10/1542	72/8135	0.8988	0.9628	0.4991	GSTP1/ALDH3B1/FMO5/MGST2/GSTO1/CYP2C8/ADH1B/ADH5/FMO3/CYP2A6	10
KEGG	hsa00591	Linoleic acid metabolism	3/1542	29/8135	0.9327	0.9959	0.5162	ALOX15/CYP2C8/PLA2G4A	3
KEGG	hsa00220	Arginine biosynthesis	2/1542	22/8135	0.9399	0.9986	0.5176	GLS/ASL	2
KEGG	hsa04974	Protein digestion and absorption	14/1542	103/8135	0.9413	0.9986	0.5176	SLC7A8/ATP1A1/ATP1B3/COL4A1/CPB2/KCNQ1/COL19A1/SLC9A3/KCNJ13/MME/KCNN4/CELA2B/SLC1A1/COL4A4	14
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1542	24/8135	0.9576	1	0.5184	EXT1/B3GAT3	2
KEGG	hsa00514	Other types of O-glycan biosynthesis	5/1542	47/8135	0.9588	1	0.5184	GALNT3/RFNG/MFNG/GALNT2/COLGALT2	5
KEGG	hsa00830	Retinol metabolism	8/1542	68/8135	0.9599	1	0.5184	CYP1A1/ALDH1A1/DGAT1/ALDH1A3/CYP2C8/ADH1B/ADH5/CYP2A6	8
KEGG	hsa00040	Pentose and glucuronate interconversions	3/1542	34/8135	0.969	1	0.5184	SORD/AKR1B1/AKR1A1	3
KEGG	hsa00910	Nitrogen metabolism	1/1542	17/8135	0.972	1	0.5184	CA5B	1
KEGG	hsa05034	Alcoholism	26/1542	187/8135	0.9734	1	0.5184	HDAC6/GNAI2/ADORA2B/ATF4/MAPK3/CREB1/GNG7/GNG5/HDAC1/HRAS/KRAS/GNB2/ARAF/SOS1/PKIA/GNAS/GNG12/GNAI1/GRB2/MAP2K1/PRKACB/PPP1CB/SLC29A1/NPY/GNAO1/SHC2	26
KEGG	hsa04975	Fat digestion and absorption	4/1542	43/8135	0.9743	1	0.5184	AGPAT1/SCARB1/DGAT1/CD36	4
KEGG	hsa04744	Phototransduction	2/1542	29/8135	0.9826	1	0.5184	PDE6G/RGS9	2
KEGG	hsa00140	Steroid hormone biosynthesis	6/1542	61/8135	0.9833	1	0.5184	CYP1A1/SRD5A1/HSD17B8/COMT/CYP1B1/HSD11B1	6
KEGG	hsa05168	Herpes simplex virus 1 infection	76/1542	495/8135	0.9866	1	0.5184	HLA-DMB/SRSF7/TNFRSF1A/OAS2/TSC2/RHEB/TYK2/TP53/AKT1/ZNF160/ZNF267/HLA-DMA/IFNAR1/TNFRSF14/POU2F1/PIK3CD/EIF2B5/CASP3/TNFSF14/IFNAR2/IFNG/STAT2/C5/HCFC1/BIRC3/ZNF84/PML/SYK/TAP1/IKBKB/FAS/ZNF282/HLA-DOB/ZNF205/ZNF124/MTOR/BAK1/ZNF133/ZNF195/IFNA2/ZNF337/BAD/ZNF132/EIF2B1/ZNF3/CHUK/IRF3/SRSF8/ZNF212/CYCS/IRAK1/STAT1/HLA-DQB1/EIF2B2/ZNF688/PDIA3/NXF1/BST2/FADD/IKBKE/AKT2/FASLG/CCL2/TRADD/ZNF248/PIK3R2/ZNF8/ZNF91/PPP1CB/TRAF6/EIF2B4/PIK3CB/HLA-A/SRPK1/ZNF780A/ZNF169	76
KEGG	hsa04260	Cardiac muscle contraction	9/1542	87/8135	0.9904	1	0.5184	CYC1/ATP1A1/UQCRC1/ATP1B3/ATP2A3/COX5A/TPM4/UQCR11/COX7A2	9
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	11/1542	109/8135	0.9963	1	0.5184	TBL3/EIF6/RPP30/RRP7A/PWP2/RAN/NXF1/CSNK2A1/POP1/GNL2/POP5	11
KEGG	hsa05033	Nicotine addiction	2/1542	40/8135	0.9977	1	0.5184	GABRG2/GABRB3	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	1/1542	29/8135	0.9978	1	0.5184	NF2	1
KEGG	hsa05322	Systemic lupus erythematosus	13/1542	136/8135	0.9992	1	0.5184	HLA-DMB/HLA-DMA/FCGR3A/CD80/IFNG/C5/HLA-DOB/HLA-DQB1/CD28/C7/ACTN4/C8B/C1R	13
KEGG	hsa04742	Taste transduction	5/1542	86/8135	0.9999	1	0.5184	PLCB3/PLCB2/ITPR3/PRKACB/SCN9A	5
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	2/1542	66/8135	1	1	0.5184	FARSA/LARS2	2
KEGG	hsa04080	Neuroactive ligand-receptor interaction	37/1542	353/8135	1	1	0.5184	ADORA3/P2RY6/PTGIR/NMB/ADORA2B/P2RY10/HRH1/ADM/HTR2B/C5/NPY1R/NR3C1/P2RX1/PTGER3/P2RY14/FPR2/GCGR/PTAFR/FSHB/GHR/CALCRL/GCG/CHRNA5/ADCYAP1/TRH/HCRTR1/PMCH/GABRG2/GAL/EDNRA/GH1/NPY/MC5R/PTGER2/GLRA3/F2R/GABRB3	37
KEGG	hsa04740	Olfactory transduction	7/1542	440/8135	1	1	0.5184	ARRB2/ADCY3/GNG7/PRKACB/RGS2/CAMK2G/OR5I1	7