ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04142	Lysosome	68/2327	132/8135	1.994e-08	6.661e-06	5.563e-06	CTSC/GGA3/GUSB/MCOLN1/SCARB2/CD164/CTSH/CTSA/NPC1/CTSF/AP4M1/GNPTG/ENTPD4/DMXL2/CLTCL1/GM2A/GNPTAB/GNS/GALC/CTSK/ATP6V0A1/TCIRG1/PLA2G15/CD68/AP4E1/TPP1/CLTB/GGA2/PSAP/ARSG/CTSO/GAA/MAN2B1/AP3M1/HEXA/CTNS/LAPTM4A/NEU1/NPC2/PPT2/SGSH/HEXB/GALNS/NAGLU/HYAL1/GBA/LAMP1/CLN3/ASAH1/ACP5/LGMN/ARSA/IDS/LAPTM5/ATP6V0D1/CTSL/HYAL2/SLC11A2/LAMP2/WDR7/AP3S2/PSAPL1/SUMF1/NAGPA/AP4S1/GLB1/CLTC/AP1M1	68
KEGG	hsa04144	Endocytosis	110/2327	251/8135	1.285e-07	2.146e-05	1.793e-05	CYTH1/ARRB1/RNF41/VPS4B/SH3KBP1/PLD1/AGAP3/ZFYVE16/STAM/ARF4/RAB11B/CLTCL1/PRKCZ/FOLR1/ARF6/TGFBR2/NEDD4/ASAP3/HSPA2/MVB12A/ACTR3C/CLTB/HSPA1A/CHMP1B/RUFY1/EHD4/HSPA6/HLA-E/PIP5K1A/RAB5A/WASL/HSPA1B/SH3GL2/TRAF6/SNX1/ARAP1/VTA1/ARPC2/HLA-G/VPS37C/NEDD4L/ARFGAP3/ASAP2/VPS29/CHMP4B/SNX4/ACAP3/HSPA8/ARPC5/HGS/SMAP2/PSD4/EPN2/AP2M1/ACTR2/WIPF3/VPS37A/EEA1/ARRB2/IGF1R/CDC42/WIPF1/ARPC5L/BIN1/RAB10/ARPC3/RAB11FIP3/SH3GLB2/VPS28/ARFGEF2/TGFBR1/AP2S1/PLD2/AGAP9/KIF5C/IST1/HRAS/SNX2/DNM2/EHD3/PSD/EPS15L1/ARF1/ARAP2/RAB11A/FGFR4/ARF5/SPG21/RHOA/SMURF2/CYTH3/IQSEC1/RAB22A/VPS37D/CYTH2/SMURF1/HLA-C/FGFR2/RAB11FIP4/CLTC/ITCH/CHMP7/VPS26B/RAB11FIP2/WIPF2/CXCR4/EHD1/AP2A1/TFRC/ARPC1A	110
KEGG	hsa04010	MAPK signaling pathway	120/2327	294/8135	3.219e-06	0.0003584	0.0002993	FGF10/MAP3K4/BDNF/DUSP16/ARRB1/VEGFB/MAPK3/DUSP10/NGF/FGF2/MAPK12/ANGPT1/PDGFC/VEGFA/TGFB3/CACNA2D3/IL1R1/IRAK1/TGFBR2/AKT2/CACNA2D4/EGF/HSPA2/TAOK3/PGF/DUSP4/HSPA1A/MAP2K7/TAB1/CSF1/MAPK11/EPHA2/MAP3K12/MAP2K1/IL1RAP/HSPA6/MAP3K8/CACNA2D1/FGF9/MAP3K1/MYC/HSPA1B/ATF4/RPS6KA3/MEF2C/TRAF6/AKT3/MAP2K5/FGF5/GNG12/FGF7/CACNA1C/ERBB4/PDGFRB/PTPRR/RAP1B/KITLG/DUSP5/MAP2K6/EFNA5/HSPA8/PLA2G4A/NTF3/TEK/SOS1/FGF1/TRADD/EFNA4/INSR/RASGRP3/MAPK8IP1/FLNC/IL1B/GADD45B/FAS/ARRB2/NRAS/IGF1R/MET/CDC42/MAPT/IL1A/FGF16/PPP3CC/GADD45G/EREG/TGFBR1/HRAS/TNF/MKNK2/MYD88/PTPN7/PRKCB/BRAF/FGFR4/EFNA3/MAP3K3/CACNA1E/STK4/PDGFD/FGFR2/GNA12/DUSP3/RPS6KA1/HGF/DUSP7/RELB/PPM1A/PAK2/FGF23/MAP3K6/PLA2G4C/KRAS/RAC2/ERBB2/RRAS/CDC25B/CACNA1F/CACNB1/IGF2	120
KEGG	hsa05132	Salmonella infection	103/2327	249/8135	8.035e-06	0.0006709	0.0005603	CYTH1/BCL2/MAPK3/IL6/DYNLRB2/EXOC4/MAPK12/RHOB/RILP/PFN2/VPS33A/PLEKHM2/TLR5/LEF1/ARHGEF26/HSP90AB1/RHOJ/IRAK1/ARF6/AKT2/VPS11/GSDMD/MYL12B/MYL10/ACTR3C/MAP2K7/FYCO1/TAB1/MAPK11/BIRC3/MAP2K1/PLEKHM1/RAB5A/MYC/DYNLT1/WASL/LY96/CASP1/TUBB2A/TRAF6/AKT3/KPNA3/ARPC2/VPS41/MAP2K6/ARPC5/SNX9/BAK1/PODXL/KPNA1/TRADD/VPS16/WASF3/NCKAP1/STX10/FLNC/PFN1/IL1B/ACTR2/CDC42/ARPC5L/DYNLL2/ANXA2/DYNC2H1/PIK3C2B/KLC4/DYNC2LI1/ARPC3/ARL8B/DCTN2/ARL8A/RIPK2/KIF5C/HRAS/KPNA4/TNF/SNX33/MYD88/AHNAK2/DNM2/CASP4/ARF1/BIRC2/MYO6/GAPDH/VPS39/RHOA/CYTH3/TNFRSF10B/CYTH2/DYNC1LI2/KLC1/PTPRC/DYNC1LI1/BRK1/ELMO1/EXOC5/IL18/TXN/RRAS/RHOG/HSP90AA1/ARPC1A	103
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	51/2327	106/8135	1.48e-05	0.0009887	0.0008257	ARRB1/AKAP13/BCL2/CREB5/MAPK3/ADCY8/PTHLH/PLD1/CREB3L4/CREB3L1/MMP14/PDE4D/ADCY1/CREB3/LRP5/RUNX2/MAFB/MEF2A/PDE4B/MAP2K1/ATF4/MEF2C/ATF6B/NR4A2/MMP16/GNAQ/LRP6/MEF2D/CYP24A1/ARRB2/GCM2/PLD2/CYP27B1/PLCB2/MMP15/GNAI3/PRKCB/BRAF/RHOA/ITPR2/PDE4A/SLC9A3R1/RXRA/ITPR1/TNFSF11/GNA12/FGF23/SP1/GNAI2/ARHGEF11/RXRG	51
KEGG	hsa03050	Proteasome	27/2327	46/8135	1.865e-05	0.001038	0.0008671	POMP/PSMB7/PSMD12/PSMA5/PSMD8/PSMA4/PSMD7/PSMB5/PSMB2/PSME4/PSMB1/PSMA7/PSME3/PSMA3/PSMD6/PSMD14/PSMB8/PSME2/PSMD11/PSMB11/PSMB9/PSMC1/PSMC3/PSMB4/PSMB10/PSMA2/PSMD13	27
KEGG	hsa04015	Rap1 signaling pathway	87/2327	210/8135	3.745e-05	0.001787	0.001492	FGF10/CDH1/VAV3/VEGFB/MAPK3/ADCY8/ITGB3/NGF/FGF2/MAPK12/ANGPT1/PDGFC/ITGB1/KRIT1/VEGFA/PFN2/RAPGEF1/LPAR1/PRKCZ/ADCY1/AKT2/EGF/PGF/VASP/CSF1/MAPK11/EPHA2/MAP2K1/FGF9/F2R/THBS1/SIPA1/AKT3/FGF5/TLN2/FGF7/PDGFRB/RAP1B/GRIN2A/KITLG/MAP2K6/EFNA5/PRKD1/ENAH/TEK/GNAQ/FGF1/EFNA4/INSR/RASGRP3/SIPA1L3/PFN1/FARP2/ADORA2A/NRAS/DRD2/IGF1R/MET/CDC42/RAPGEF6/FGF16/RALB/PLCB2/HRAS/MAGI2/DOCK4/APBB1IP/GNAI3/PRKCB/BRAF/FGFR4/RHOA/EFNA3/PDGFD/RALGDS/FGFR2/HGF/RAPGEF5/FGF23/PLCG1/P2RY1/KRAS/GNAI2/RAPGEF3/RAC2/TLN1/RRAS	87
KEGG	hsa04141	Protein processing in endoplasmic reticulum	73/2327	171/8135	4.867e-05	0.002032	0.001697	BCL2/MAN1A1/UBE2J1/SEC63/HERPUD1/HSP90AB1/XBP1/SEC23A/CRYAB/HSPA2/SEC31A/SSR3/HSPA1A/SEC24D/MAP2K7/SEC61B/HSPA6/MAN1C1/OS9/SEC13/HSPA1B/ATF6/ATF4/SEC24A/ATF6B/EIF2S1/DNAJB2/SEC61G/CASP12/DNAJC1/SSR1/DNAJC10/SEC23B/TRAM1L1/CKAP4/UBQLN1/STT3A/UBXN6/HSPA8/UBE4B/SAR1A/RNF185/UBE2G2/UGGT2/BAK1/EIF2AK3/YOD1/SEC61A1/PRKCSH/BAG1/UBXN2A/EDEM2/RAD23B/HSPA5/DAD1/UBE2D2/ERLEC1/UBXN1/DNAJC5/EIF2AK4/ATXN3/LMAN1/MBTPS2/UBXN8/DNAJB11/ERN1/UBE2D3/MOGS/SEC31B/RRBP1/BCAP31/DNAJA2/HSP90AA1	73
KEGG	hsa05017	Spinocerebellar ataxia	61/2327	143/8135	0.0002029	0.007528	0.006287	ATG13/AMBRA1/TBPL1/ATP2A3/SLC25A4/XBP1/AKT2/PIK3R4/PSMB7/VLDLR/CIC/ATXN10/GRIA1/ATG2B/RB1CC1/ATG2A/PSMD12/AKT3/NOP56/GRIN2A/PSMA5/VDAC2/PSMD8/PSMA4/ATG14/GNAQ/PSMD7/PSMB5/PSMB2/PSMB1/PSMA7/WIPI1/ULK2/GRIN2D/ULK1/PSMA3/PSMD6/ATXN1L/OMA1/PSMD14/PLCB2/NRBF2/VDAC1/PSMD11/PRKCB/WIPI2/ATXN3/ITPR2/ERN1/PSMC1/ITPR1/ATXN1/GRIA3/PSMC3/PSMB4/FGF14/SP1/PSMA2/PSMD13/AFG3L2/ATXN2L	61
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	11/2327	15/8135	0.0004214	0.01407	0.01175	B3GALT4/ST6GALNAC6/ST3GAL5/HEXA/HEXB/ST6GALNAC5/ST6GALNAC3/ST6GALNAC4/ST8SIA5/SLC33A1/GLB1	11
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	44/2327	100/8135	0.000686	0.02083	0.0174	NOX4/COL1A1/BCL2/VEGFB/MAPK3/IL6/FOXO1/MAPK12/VEGFA/TGFB3/PIM1/STAT5A/PRKCZ/TGFBR2/AGTR1/AKT2/PLCD3/MAPK11/VCAM1/AKT3/STAT1/EDN1/PRKCE/MMP2/IL1B/NRAS/SERPINE1/CDC42/IL1A/TGFBR1/PLCB2/HRAS/TNF/COL4A4/PRKCB/FN1/STAT5B/CCL2/F3/PLCD4/CCND1/PLCG1/KRAS/COL1A2	44
KEGG	hsa04140	Autophagy - animal	58/2327	141/8135	0.0008701	0.02422	0.02023	ATG13/RAB39B/BCL2/MAPK3/DAPK2/AMBRA1/ZFYVE1/DAPK1/MTMR3/TSC2/MTMR14/AKT2/PIK3R4/STK11/DEPTOR/MAP2K1/ATG2B/RB1CC1/ATG2A/TP53INP2/RRAGD/TRAF6/AKT3/EIF2S1/MTMR4/DDIT4/TSC1/GABARAPL1/WDR41/ATG14/EIF2AK3/LAMP1/MAP1LC3A/WIPI1/ULK2/NRAS/IGF1R/SNAP29/ULK1/BAD/SMCR8/HRAS/NRBF2/CTSL/LAMP2/GABARAP/EIF2AK4/WIPI2/ATG7/ATG12/ERN1/ITPR1/BCL2L1/MAP1LC3C/KRAS/RRAS/IRS2/ATG3	58
KEGG	hsa04510	Focal adhesion	78/2327	201/8135	0.001026	0.02637	0.02202	COL1A1/VAV3/BCL2/LAMA2/ACTN1/VEGFB/MAPK3/ITGB3/PDGFC/ITGB1/VEGFA/RAPGEF1/ITGAV/LAMB1/AKT2/EGF/MYL12B/MYL10/ITGB5/ITGA2/PGF/VASP/BIRC3/MAP2K1/THBS1/PIP5K1A/ARHGAP35/SHC1/AKT3/TLN2/ITGA4/PDGFRB/PARVB/RAP1B/LAMA4/LAMA3/CHAD/VCL/SOS1/PTK2/FLNC/LAMA1/ITGA5/IGF1R/MET/CDC42/ROCK1/BAD/HRAS/ITGA6/LAMC1/COL4A4/THBS4/PRKCB/BRAF/LAMB4/BIRC2/SHC2/FN1/RHOA/MYLK3/ITGB7/ITGB8/SPP1/ITGB6/CCND2/PDGFD/VTN/IBSP/HGF/VWF/PAK2/COL6A2/CCND1/RAC2/ERBB2/TLN1/COL1A2	78
KEGG	hsa05130	Pathogenic Escherichia coli infection	76/2327	197/8135	0.001433	0.03215	0.02685	TJP1/CYTH1/MAPK3/IL6/MYO1B/MAPK12/ITGB1/FCGR2A/TLR5/LPAR1/IL1R1/IRAK1/ARF6/ABL1/CLDN11/ACTR3C/ARHGEF2/SEC24D/TAB1/MAPK11/MYO1F/MYO1D/F2R/WASL/CASP1/SEC24A/TUBB2A/TRAF6/ARPC2/CLDN23/CLDN4/MYO1E/ARPC5/MYO1H/BAK1/TRADD/CASP9/WASF3/NCL/NCKAP1/IL1B/ACTR2/FAS/WIPF3/MYO5B/CDC42/WIPF1/ARPC5L/ROCK1/ARPC3/MYO1A/TNF/MYD88/CLDN1/CASP4/WASF2/ARF1/MYO6/GAPDH/RHOA/CYTH3/NCK2/SLC9A3R1/MYO1C/TNFRSF10B/OCLN/CYTH2/GNA12/CTTN/CLDN15/PAK2/BRK1/WIPF2/IL18/ARHGEF11/ARPC1A	76
KEGG	hsa04151	PI3K-Akt signaling pathway	127/2327	354/8135	0.001444	0.03215	0.02685	FGF10/GNB5/BDNF/COL1A1/BCL2/LAMA2/CREB5/VEGFB/MAPK3/IL6/ITGB3/NGF/FGF2/ANGPT1/BCL2L11/PCK2/PDGFC/CREB3L4/ITGB1/VEGFA/CREB3L1/ITGAV/GNG7/CDK6/LPAR1/LPAR6/IL7/HSP90AB1/TSC2/LAMB1/CREB3/YWHAB/AKT2/PHLPP1/EGF/STK11/ITGB5/ITGA2/PGF/CSF1/EIF4EBP1/EPHA2/MAP2K1/RBL2/FGF9/F2R/THBS1/MYC/ATF4/ATF6B/AKT3/FGF5/GNG12/PPP2R3A/FGF7/ERBB4/ITGA4/DDIT4/TSC1/PDGFRB/GNB4/LAMA4/CRTC2/LAMA3/KITLG/CHAD/EFNA5/NTF3/TEK/SOS1/FGF1/CASP9/EFNA4/PTK2/INSR/LAMA1/CDC37/ITGA5/NRAS/IGF1R/PPP2R2C/MET/EIF4E2/IL6R/FGF16/EREG/BAD/HRAS/ITGA6/LAMC1/PPP2R1A/COL4A4/MAGI2/YWHAZ/THBS4/GNB1/LAMB4/FGFR4/FN1/ITGB7/EFNA3/ITGB8/SPP1/ITGB6/RXRA/CCND2/PDGFD/SYK/PRL/PPP2R5D/FGFR2/BCL2L1/VTN/IBSP/HGF/VWF/COL6A2/FGF23/EIF4E/CCND1/CD19/GNB3/KRAS/ERBB2/COL1A2/HSP90AA1/IGF2	127
KEGG	hsa04150	mTOR signaling pathway	62/2327	156/8135	0.001648	0.03426	0.02862	MAPK3/STRADB/FZD6/SESN2/SLC7A5/PRR5/WNT9B/ATP6V1B2/TSC2/FNIP2/FNIP1/SEH1L/LRP5/RICTOR/AKT2/STK11/FZD1/DEPTOR/EIF4EBP1/LPIN3/MAP2K1/SEC13/RPS6KA3/DVL2/ATP6V1G3/RRAGD/AKT3/ATP6V1C1/DDIT4/TSC1/FZD10/LAMTOR4/LPIN1/LRP6/SOS1/INSR/ATP6V1A/WDR24/ULK2/WDR59/NRAS/IGF1R/EIF4E2/CLIP1/ULK1/SLC38A9/HRAS/TNF/PRKCB/BRAF/RHOA/LPIN2/WNT9A/WNT5B/RNF152/LAMTOR1/RPS6KA1/ATP6V1F/FZD8/EIF4E/KRAS/ATP6V1E1	62
KEGG	hsa00531	Glycosaminoglycan degradation	12/2327	19/8135	0.001778	0.03426	0.02862	GUSB/GNS/HEXA/SGSH/HEXB/GALNS/NAGLU/HYAL1/HPSE/IDS/HYAL2/GLB1	12
KEGG	hsa05165	Human papillomavirus infection	119/2327	331/8135	0.001847	0.03426	0.02862	PTGER4/COL1A1/LLGL1/LAMA2/CREB5/MAPK3/FOXO1/ITGB3/PTGS2/FZD6/TBPL1/CREB3L4/ITGB1/VEGFA/CREB3L1/ITGAV/WNT9B/CDK6/PRKCZ/ATP6V1B2/ATP6V0A1/TSC2/TCIRG1/LAMB1/CREB3/AKT2/EGF/FZD1/ITGB5/ITGA2/EIF4EBP1/MAP2K1/RBL2/HLA-E/THBS1/IRF9/DLG2/DVL2/ATP6V1G3/HES6/AKT3/STAT1/PPP2R3A/ATP6V1C1/OASL/HLA-G/ITGA4/TSC1/PDGFRB/DLG3/FZD10/LAMA4/STAT2/JAG1/LAMA3/CHAD/CHD4/BAK1/SOS1/TRADD/PTK2/MAML1/ATP6V1A/LAMA1/NOTCH2/FAS/DLG1/ITGA5/TRAF3/NRAS/MAML3/PPP2R2C/MX1/CDC42/LFNG/BAD/ATP6V0D1/HRAS/MAML2/ITGA6/LAMC1/PPP2R1A/TNF/CSNK1A1/CREBBP/COL4A4/THBS4/LAMB4/FN1/UBR4/HDAC2/ITGB7/SLC9A3R1/ITGB8/SPP1/ITGB6/WNT9A/PSMC1/TLR3/CCND2/MPP5/PPP2R5D/WNT5B/HLA-C/VTN/IBSP/ATP6V1F/VWF/FZD8/APC2/ATP6V0E2/COL6A2/CCND1/KRAS/BCAP31/COL1A2/IRF3/ATP6V1E1/CSNK1A1L	119
KEGG	hsa02010	ABC transporters	22/2327	45/8135	0.003083	0.05419	0.04526	ABCC5/ABCA7/ABCG1/ABCD4/ABCA1/ABCC4/ABCB5/ABCB7/ABCA10/ABCA8/ABCB10/ABCD2/DEFB1/CFTR/ABCC2/ABCB8/ABCA6/ABCC1/ABCA5/ABCA4/ABCC6/ABCB11	22
KEGG	hsa00330	Arginine and proline metabolism	24/2327	51/8135	0.003838	0.06409	0.05353	SAT1/ALDH18A1/PYCR1/ALDH4A1/SRM/P4HA3/LAP3/ODC1/ALDH3A2/GOT1/CKB/P4HA1/ALDH1B1/OAT/HOGA1/SMS/P4HA2/SMOX/PYCR2/GOT2/CKMT2/CKM/SAT2/AGMAT	24
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	34/2327	79/8135	0.004125	0.0656	0.05479	BCL2/MAPK3/IL6/FGF2/BCL2L11/PDGFC/VEGFA/AKT2/EGF/EIF4EBP1/MAP2K1/SHC1/AKT3/PDGFRB/SOS1/NRAS/IGF1R/MET/EIF4E2/IL6R/BAD/HRAS/PRKCB/BRAF/SHC2/PDGFD/FGFR2/BCL2L1/HGF/EIF4E/PLCG1/KRAS/ERBB2/NRG1	34
KEGG	hsa03060	Protein export	13/2327	23/8135	0.004581	0.06954	0.05808	SEC63/SEC61B/IMMP2L/SRPRB/SEC61G/SRP19/SRP72/SPCS2/SEC61A1/HSPA5/OXA1L/SRP68/SPCS3	13
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	40/2327	97/8135	0.004916	0.07138	0.05962	GAB2/VAV3/MAPK3/PLD1/GSN/FCGR2A/HCK/ARF6/AKT2/ASAP3/ACTR3C/MARCKSL1/LYN/VASP/MAP2K1/PIP5K1A/AKT3/ARPC2/ASAP2/PRKCE/PLA2G4A/ARPC5/WASF3/ACTR2/CDC42/ARPC5L/BIN1/ARPC3/PLD2/DNM2/WASF2/PLA2G6/PRKCB/SYK/PTPRC/PLCG1/PLA2G4C/RAC2/INPP5D/ARPC1A	40
KEGG	hsa05218	Melanoma	31/2327	72/8135	0.005962	0.08297	0.0693	FGF10/CDH1/MITF/MAPK3/FGF2/PDGFC/CDK6/AKT2/EGF/MAP2K1/FGF9/AKT3/FGF5/FGF7/PDGFRB/BAK1/FGF1/GADD45B/NRAS/IGF1R/MET/FGF16/GADD45G/BAD/HRAS/BRAF/PDGFD/HGF/FGF23/CCND1/KRAS	31
KEGG	hsa04014	Ras signaling pathway	84/2327	232/8135	0.006568	0.08775	0.07329	FGF10/GNB5/GAB2/BDNF/VEGFB/MAPK3/NGF/PLD1/FGF2/RGL2/ANGPT1/PDGFC/VEGFA/GNG7/RGL1/ARF6/AKT2/EGF/ABL1/PGF/FOXO4/CSF1/EPHA2/MAP2K1/FGF9/SHOC2/RAB5A/SHC1/AKT3/FGF5/GNG12/FGF7/PDGFRB/RAP1B/GNB4/GRIN2A/KITLG/SYNGAP1/EFNA5/PLA2G4A/NTF3/TEK/SOS1/FGF1/EFNA4/INSR/RASGRP3/NRAS/IGF1R/MET/CDC42/FGF16/BAD/PLD2/RALB/HRAS/PLA2G2A/PLA2G6/GNB1/PRKCB/SHC2/FGFR4/PLA1A/RHOA/EFNA3/KSR2/STK4/PDGFD/ABL2/RALGDS/FGFR2/RIN1/BCL2L1/HGF/RAPGEF5/PAK2/FGF23/PLCG1/GNB3/PLA2G4C/KRAS/RAC2/RRAS/IGF2	84
KEGG	hsa05216	Thyroid cancer	18/2327	37/8135	0.007634	0.09619	0.08034	CDH1/MAPK3/PPARG/LEF1/MAP2K1/MYC/BAK1/GADD45B/NRAS/TFG/GADD45G/HRAS/BRAF/CCDC6/RXRA/CCND1/KRAS/RXRG	18
KEGG	hsa04915	Estrogen signaling pathway	53/2327	138/8135	0.007776	0.09619	0.08034	GPER1/KRT33B/BCL2/CREB5/MAPK3/ADCY8/NCOA3/CREB3L4/KRT34/CREB3L1/HSP90AB1/KRT19/ADCY1/CREB3/AKT2/HSPA2/FKBP5/HSPA1A/MAP2K1/HSPA6/HSPA1B/ATF4/PGR/KRT23/ATF6B/NCOA2/SHC1/AKT3/HSPA8/NCOA1/GNAQ/KRT18/SOS1/GABBR2/MMP2/NRAS/KRT16/PLCB2/HRAS/KRT15/GNAI3/SHC2/KRT38/KRT14/ITPR2/KRT27/ITPR1/RARA/KRT24/SP1/KRAS/GNAI2/HSP90AA1	53
KEGG	hsa05135	Yersinia infection	52/2327	137/8135	0.01078	0.1115	0.09313	VAV3/MAPK3/IL6/MAPK12/ITGB1/FCGR2A/IRAK1/ARF6/AKT2/ACTR3C/MAP2K7/TAB1/MAPK11/MAP2K1/PIP5K1A/WASL/RPS6KA3/CASP1/TRAF6/AKT3/ARPC2/ITGA4/MAP2K6/ARPC5/GNAQ/PTK2/IL1B/ACTR2/WIPF3/ITGA5/CDC42/WIPF1/MEFV/ARPC5L/ROCK1/ARPC3/TNF/MYD88/WASF2/ARHGEF28/FN1/RHOA/CCL2/RPS6KA1/PLCG1/ELMO1/WIPF2/RAC2/IL18/RHOG/IRF3/ARPC1A	52
KEGG	hsa00564	Glycerophospholipid metabolism	39/2327	98/8135	0.01082	0.1115	0.09313	AGPAT4/PLD1/PNPLA7/CRLS1/MBOAT1/PLA2G15/CDS2/LPIN3/CHKA/LPCAT3/CDS1/PTDSS2/PISD/GPD1L/DGKH/PTDSS1/PGS1/CHPT1/PLA2G4A/LPIN1/DGKE/LCLAT1/CDIPT/LPCAT4/GPAM/LPCAT2/LYPLA1/PLD3/PLD2/DGKA/PLA2G2A/PLA2G6/DGKG/PLA1A/GPCPD1/LPIN2/LPGAT1/GPAT2/PLA2G4C	39
KEGG	hsa05231	Choline metabolism in cancer	39/2327	98/8135	0.01082	0.1115	0.09313	MAPK3/PLD1/PDGFC/TSC2/SLC22A4/AKT2/SLC44A1/EGF/EIF4EBP1/MAP2K1/CHKA/PIP5K1A/AKT3/DGKH/TSC1/PDGFRB/CHPT1/PLA2G4A/SOS1/WASF3/DGKE/SLC22A3/NRAS/LYPLA1/PLD2/DGKA/SLC44A5/HRAS/WASF2/PRKCB/DGKG/GPCPD1/PDGFD/RALGDS/PLCG1/PLA2G4C/SP1/KRAS/RAC2	39
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	22/2327	49/8135	0.01082	0.1115	0.09313	GFPT1/RENBP/AMDHD2/GFPT2/NANS/CYB5R4/GALK2/HEXA/GNPNAT1/HKDC1/HEXB/UAP1L1/CYB5RL/NPL/PGM1/CMAS/PGM3/PMM2/NANP/GNPDA1/GALT/PGM2	22
KEGG	hsa00730	Thiamine metabolism	9/2327	15/8135	0.0109	0.1115	0.09313	AK7/AK5/AK2/NTPCR/AK8/ACP1/ALPL/AK4/AK1	9
KEGG	hsa04071	Sphingolipid signaling pathway	46/2327	119/8135	0.01102	0.1115	0.09313	GAB2/BCL2/MAPK3/PLD1/MAPK12/SGPP1/PRKCZ/SMPD2/AKT2/MAPK11/MAP2K1/CERS4/AKT3/PPP2R3A/PRKCE/GNAQ/TRADD/ASAH1/BID/SGMS2/NRAS/PPP2R2C/ACER2/ROCK1/DEGS1/SGPL1/PLD2/PLCB2/HRAS/PPP2R1A/TNF/SPTLC1/BDKRB2/ABCC1/GNAI3/PRKCB/S1PR1/RHOA/CERS5/PPP2R5D/GNA12/CERS2/KRAS/ASAH2/GNAI2/RAC2	46
KEGG	hsa00600	Sphingolipid metabolism	23/2327	52/8135	0.01147	0.1116	0.09324	UGCG/SGPP1/GALC/SMPD2/KDSR/PSAP/HEXA/CERS4/NEU1/HEXB/GBA/ASAH1/SGMS2/ARSA/ACER2/DEGS1/SGPL1/SPTLC1/PSAPL1/CERS5/CERS2/GLB1/ASAH2	23
KEGG	hsa04216	Ferroptosis	19/2327	41/8135	0.0117	0.1116	0.09324	CP/SLC7A11/SAT1/GCLM/GPX4/LPCAT3/PRNP/VDAC2/MAP1LC3A/SLC40A1/SLC11A2/FTH1/GCLC/ATG7/SAT2/ACSL6/SLC39A8/MAP1LC3C/TFRC	19
KEGG	hsa05417	Lipid and atherosclerosis	77/2327	215/8135	0.01203	0.1116	0.09324	VAV3/BCL2/MAPK3/IL6/ABCG1/IL12A/PPARG/MAPK12/ABCA1/HSP90AB1/XBP1/IRAK1/HSPD1/AKT2/HSPA2/CD40/IRF7/LYN/HSPA1A/VLDLR/MAP2K7/TAB1/MAPK11/POU2F1/HSPA6/VCAM1/LY96/HSPA1B/ATF6/ATF4/CASP1/TRAF6/AKT3/EIF2S1/CD36/RAP1B/MAP2K6/CYP2C8/HSPA8/LBP/APOB/EIF2AK3/CASP9/PTK2/BID/APOA1/IL1B/FAS/TRAF3/NRAS/CDC42/CXCL2/HSPA5/PPP3CC/CAMK2A/BAD/PLCB2/HRAS/TNF/MYD88/RHOA/RXRA/CCL2/ERN1/TNFRSF10B/ITPR1/POU2F3/BCL2L1/PLCG1/CYP2A7/KRAS/NCF2/IL18/IRF3/SOD2/RXRG/HSP90AA1	77
KEGG	hsa00480	Glutathione metabolism	25/2327	58/8135	0.01258	0.1124	0.09386	PRDX6/GCLM/GSTO1/CHAC1/GPX3/SRM/GPX4/LAP3/ODC1/GGT7/GSTM4/GPX8/GSTK1/SMS/GSTP1/GSTA1/TXNDC12/MGST1/GPX1/GCLC/OPLAH/GSR/MGST3/GSTM2/CHAC2	25
KEGG	hsa05410	Hypertrophic cardiomyopathy	36/2327	90/8135	0.01279	0.1124	0.09386	PRKAG3/LAMA2/IL6/ITGB3/ITGB1/ATP2A3/ITGAV/TGFB3/CACNA2D3/SLC8A1/CACNA2D4/SGCA/ITGB5/ITGA2/CACNA2D1/RYR2/DES/CACNA1C/EDN1/DMD/ITGA4/TPM1/TTN/LAMA1/ITGA5/PRKAB1/TNNC1/ITGA6/TNF/TPM2/ITGB7/ITGB8/ITGB6/MYL3/CACNA1F/CACNB1	36
KEGG	hsa04360	Axon guidance	66/2327	182/8135	0.01423	0.1218	0.1018	SEMA4C/PLXNC1/ABLIM1/MAPK3/EFNB1/EPHB1/SEMA6C/SSH1/ITGB1/EPHA5/SMO/UNC5B/PRKCZ/UNC5C/SEMA3C/SEMA3B/SEMA6A/ABL1/MYL12B/SEMA5B/EPHA2/SEMA6D/SEMA5A/SSH3/EFNA5/ENAH/PTCH1/SLIT2/EFNA4/PTK2/EPHB3/NRAS/EFNB3/MET/SEMA3E/CDC42/ROCK1/PPP3CC/PLXNB2/CAMK2A/RYK/SEMA4B/FES/NTNG1/ABLIM3/HRAS/NTN4/GNAI3/LRIG2/RHOA/NCK2/EFNA3/ROBO2/WNT5B/PAK2/NRP1/PLCG1/KRAS/GNAI2/RAC2/ABLIM2/EPHA3/CXCR4/RRAS/PLXNA2/SEMA3G	66
KEGG	hsa04919	Thyroid hormone signaling pathway	46/2327	121/8135	0.01532	0.1265	0.1056	MAPK3/FOXO1/ITGB3/NCOA3/ATP2A3/ITGAV/ATP1A2/TSC2/AKT2/PFKFB2/THRA/PLCD3/MAP2K1/ATP1A3/MYC/NCOA2/AKT3/STAT1/NCOA1/CASP9/NOTCH2/NRAS/ATP1B2/SLC2A1/MED12L/BAD/DIO2/PLCB2/HRAS/CREBBP/ATP1A1/MED16/PRKCB/HDAC2/RXRA/PLCD4/MED12/MED4/SLCO1C1/CCND1/PLCG1/KRAS/SLC16A10/RXRG/NCOR1/RCAN2	46
KEGG	hsa04668	TNF signaling pathway	43/2327	112/8135	0.01552	0.1265	0.1056	CREB5/MAPK3/IL6/PTGS2/MAPK12/CREB3L4/CREB3L1/MMP14/TNFAIP3/CREB3/CEBPB/AKT2/SOCS3/MAP2K7/TAB1/CSF1/MAPK11/BIRC3/MAP2K1/MAP3K8/VCAM1/ATF4/ATF6B/AKT3/EDN1/JAG1/MAP2K6/TRADD/DNM1L/IL1B/FAS/TRAF3/CXCL2/LIF/JUNB/TNF/BIRC2/CCL20/IL18R1/CCL2/DAB2IP/ITCH/TRAF5	43
KEGG	hsa04068	FoxO signaling pathway	49/2327	131/8135	0.01749	0.1292	0.1079	PRKAG3/MAPK3/IL6/FOXO1/MAPK12/BCL2L11/PCK2/TGFB3/TGFBR2/AKT2/PLK2/EGF/STK11/FOXO4/MAPK11/MAP2K1/CCNG2/RBL2/AKT3/GABARAPL1/KLF2/SOS1/CCNB3/INSR/GADD45B/NRAS/PRKAB1/USP7/IGF1R/GADD45G/PRMT1/TGFBR1/HRAS/CREBBP/BCL6/FBXO32/BRAF/GABARAP/S1PR1/RAG1/ATG12/CCND2/STK4/CCND1/KRAS/RAG2/SLC2A4/SOD2/IRS2	49
KEGG	hsa04520	Adherens junction	29/2327	71/8135	0.01756	0.1292	0.1079	TJP1/CDH1/SORBS1/ACTN1/MAPK3/LEF1/TGFBR2/WASL/PTPRJ/PTPRB/VCL/CSNK2A1/WASF3/INSR/LMO7/FARP2/IGF1R/MET/CDC42/TGFBR1/CREBBP/ACP1/WASF2/RHOA/YES1/SNAI2/CSNK2A3/RAC2/ERBB2	29
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	31/2327	77/8135	0.01803	0.1292	0.1079	LAMA2/ITGB3/ITGB1/DSP/ATP2A3/ITGAV/CACNA2D3/LEF1/SLC8A1/CACNA2D4/SGCA/ITGB5/ITGA2/CACNA2D1/RYR2/DES/CACNA1C/DMD/ITGA4/CDH2/LAMA1/ITGA5/ITGA6/JUP/ITGB7/ITGB8/ITGB6/PKP2/ACTN3/CACNA1F/CACNB1	31
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	17/2327	37/8135	0.01836	0.1292	0.1079	DDO/GPT2/GFPT1/ASNS/GLUD2/GFPT2/ALDH4A1/RIMKLB/ALDH5A1/ADSL/GOT1/FOLH1/ABAT/GOT2/ASPA/GLUL/PPAT	17
KEGG	hsa00270	Cysteine and methionine metabolism	22/2327	51/8135	0.01839	0.1292	0.1079	CTH/GCLM/PSAT1/LDHB/CBS/BCAT1/SRM/LDHA/DNMT3B/LDHAL6B/LACC1/GOT1/AHCYL2/APIP/SMS/TST/ENOPH1/MTAP/GOT2/GCLC/PHGDH/SDS	22
KEGG	hsa04211	Longevity regulating pathway	35/2327	89/8135	0.01853	0.1292	0.1079	PRKAG3/ATG13/CREB5/ADIPOR2/FOXO1/ADCY8/PPARG/SESN2/CREB3L4/CREB3L1/TSC2/ADCY1/CREB3/AKT2/STK11/EIF4EBP1/RB1CC1/ATF4/ATF6B/AKT3/TSC1/PPARGC1A/EHMT2/SESN3/INSR/NRAS/PRKAB1/IGF1R/EIF4E2/ULK1/HRAS/EIF4E/KRAS/SOD2/IRS2	35
KEGG	hsa05222	Small cell lung cancer	36/2327	92/8135	0.01857	0.1292	0.1079	BCL2/LAMA2/FHIT/PTGS2/ITGB1/ITGAV/CDK6/LAMB1/AKT2/ITGA2/BIRC7/BIRC3/MYC/TRAF6/AKT3/LAMA4/LAMA3/TRAF4/BAK1/CASP9/PTK2/LAMA1/GADD45B/TRAF3/GADD45G/ITGA6/LAMC1/COL4A4/LAMB4/BIRC2/FN1/RXRA/BCL2L1/TRAF5/CCND1/RXRG	36
KEGG	hsa05223	Non-small cell lung cancer	29/2327	72/8135	0.02156	0.147	0.1228	MAPK3/FHIT/CDK6/STAT5A/AKT2/EGF/MAP2K1/AKT3/BAK1/SOS1/CASP9/GADD45B/NRAS/MET/GADD45G/BAD/KIF5C/HRAS/PRKCB/BRAF/STAT5B/RXRA/STK4/HGF/CCND1/PLCG1/KRAS/ERBB2/RXRG	29
KEGG	hsa04066	HIF-1 signaling pathway	41/2327	109/8135	0.02545	0.17	0.142	BCL2/MAPK3/IL6/ANGPT1/VEGFA/LDHB/AKT2/EGF/LDHA/EIF4EBP1/MAP2K1/AKT3/LTBR/LDHAL6B/EDN1/HKDC1/TEK/ARNT/INSR/EGLN2/SERPINE1/IGF1R/SLC2A1/EIF4E2/IL6R/CAMK2A/TIMP1/PDHB/MKNK2/CREBBP/PRKCB/GAPDH/ENO4/ALDOC/ENO2/PDHA1/EIF4E/PLCG1/ERBB2/TFRC/ENO1	41
KEGG	hsa04340	Hedgehog signaling pathway	23/2327	56/8135	0.03012	0.1973	0.1648	CDON/EFCAB7/ARRB1/IQCE/BCL2/GLI3/SMO/SUFU/HHIP/GLI2/PTCH1/DISP1/ARRB2/PTCH2/GAS1/CSNK1G2/CSNK1A1/HHATL/SMURF2/CCND2/SMURF1/CCND1/CSNK1A1L	23
KEGG	hsa05100	Bacterial invasion of epithelial cells	30/2327	77/8135	0.03169	0.2036	0.17	CDH1/ITGB1/ARHGEF26/CLTCL1/CD2AP/ACTR3C/CLTB/WASL/SHC1/ARPC2/VCL/ARHGAP10/ARPC5/PTK2/ACTR2/ITGA5/MET/CDC42/ARPC5L/ARPC3/DNM2/WASF2/SHC2/FN1/RHOA/CLTC/CTTN/ELMO1/RHOG/ARPC1A	30
KEGG	hsa04072	Phospholipase D signaling pathway	53/2327	148/8135	0.03296	0.2077	0.1735	GAB2/CYTH1/AGPAT4/MAPK3/ADCY8/PLD1/PDGFC/LPAR1/LPAR6/TSC2/ADCY1/ARF6/AGTR1/AKT2/EGF/MAP2K1/F2R/PIP5K1A/SHC1/AKT3/DGKH/TSC1/PDGFRB/KITLG/PLA2G4A/SOS1/INSR/DGKE/NRAS/GRM8/PLD2/DGKA/RALB/PLCB2/HRAS/AVPR2/DNM2/ARF1/DGKG/SHC2/RHOA/CYTH3/GRM3/PDGFD/CYTH2/SYK/RALGDS/GNA12/PLCG1/PLA2G4C/KRAS/RAPGEF3/RRAS	53
KEGG	hsa00670	One carbon pool by folate	10/2327	20/8135	0.03496	0.2162	0.1806	ALDH1L2/MTHFD2/SHMT2/GART/MTHFD2L/MTHFD1L/ATIC/MTHFR/MTHFS/FTCD	10
KEGG	hsa05226	Gastric cancer	53/2327	149/8135	0.03731	0.2266	0.1892	FGF10/CDH1/BCL2/MAPK3/FZD6/FGF2/TGFB3/WNT9B/LEF1/TGFBR2/LRP5/AKT2/EGF/FZD1/MAP2K1/FGF9/MYC/DVL2/SHC1/AKT3/FGF5/FGF7/CDH17/FZD10/LRP6/BAK1/SOS1/FGF1/GADD45B/NRAS/MET/FGF16/GADD45G/FRAT1/TGFBR1/HRAS/JUP/CSNK1A1/BRAF/SHC2/RXRA/WNT9A/WNT5B/FGFR2/HGF/FZD8/APC2/FGF23/CCND1/KRAS/ERBB2/RXRG/CSNK1A1L	53
KEGG	hsa05145	Toxoplasmosis	41/2327	112/8135	0.03964	0.2304	0.1924	BCL2/LAMA2/MAPK3/IL12A/MAPK12/ITGB1/TGFB3/LAMB1/IRAK1/AKT2/HSPA2/CD40/BIRC7/HSPA1A/TAB1/MAPK11/BIRC3/HSPA6/LY96/HSPA1B/TRAF6/AKT3/STAT1/HLA-DMA/LAMA4/LAMA3/MAP2K6/HSPA8/CASP9/LAMA1/BAD/ITGA6/LAMC1/TNF/MYD88/GNAI3/LAMB4/BIRC2/IRGM/BCL2L1/GNAI2	41
KEGG	hsa05143	African trypanosomiasis	16/2327	37/8135	0.0401	0.2304	0.1924	IL6/IL12A/VCAM1/LAMA4/GNAQ/F2RL1/APOA1/IL1B/FAS/PLCB2/TNF/MYD88/PRKCB/HBB/HPR/IL18	16
KEGG	hsa04070	Phosphatidylinositol signaling system	36/2327	97/8135	0.04225	0.2304	0.1924	INPP4B/PI4K2A/ITPKB/IMPA2/MTMR1/MTMR3/INPP5A/IP6K1/MTMR14/CDS2/PLCD3/PIP5K1A/CDS1/DGKH/MTMR4/IPMK/MTMR8/DGKE/CDIPT/INPP1/PIK3C2B/DGKA/PLCB2/MTMR2/PI4KA/PRKCB/DGKG/SYNJ1/ITPR2/ITPR1/PLCD4/IMPA1/PLCG1/OCRL/IPPK/INPP5D	36
KEGG	hsa04350	TGF-beta signaling pathway	35/2327	94/8135	0.04273	0.2304	0.1924	NBL1/MAPK3/ZFYVE16/FBN1/RGMB/TGFB3/ACVR2B/CHRD/TGFBR2/INHBE/GDF5/DCN/ACVR1/BMP2/ID3/THBS1/MYC/BMP6/ID4/ROCK1/TGFBR1/SMAD6/PPP2R1A/TNF/CREBBP/RHOA/SMURF2/INHBA/NODAL/INHBB/SMURF1/THSD4/SMAD9/SP1/SMAD1	35
KEGG	hsa04512	ECM-receptor interaction	33/2327	88/8135	0.04362	0.2304	0.1924	COL1A1/LAMA2/ITGB3/ITGB1/ITGAV/LAMB1/FRAS1/ITGB5/ITGA2/THBS1/SDC4/ITGA4/CD36/LAMA4/LAMA3/CHAD/LAMA1/ITGA5/ITGA6/LAMC1/COL4A4/THBS4/LAMB4/FN1/ITGB7/ITGB8/SPP1/ITGB6/VTN/IBSP/VWF/COL6A2/COL1A2	33
KEGG	hsa01232	Nucleotide metabolism	32/2327	85/8135	0.04403	0.2304	0.1924	AK7/DCTD/UCK2/ENTPD4/AK5/ENTPD3/AK9/DGUOK/GUK1/ADSL/AK2/CTPS1/UCK1/LACC1/NTPCR/CMPK1/NME4/ENTPD1/NME1/PNP/AK8/CDA/XDH/IMPDH1/CMPK2/CTPS2/DCTPP1/AK4/AK1/HPRT1/IMPDH2/TYMP	32
KEGG	hsa04146	Peroxisome	31/2327	82/8135	0.0444	0.2304	0.1924	DDO/ABCD4/ACOT8/PEX16/MPV17/PEX11A/PHYH/CRAT/FAR1/FAR2/NUDT19/CROT/AGPS/ECH1/PAOX/EPHX2/HMGCL/ABCD2/PRDX5/MLYCD/GSTK1/PEX11G/PECR/PEX6/XDH/PEX13/SCP2/PXMP4/ACSL6/MPV17L/SOD2	31
KEGG	hsa00511	Other glycan degradation	9/2327	18/8135	0.04475	0.2304	0.1924	ENGASE/MAN2C1/MAN2B1/HEXA/NEU1/HEXB/GBA/MAN2B2/GLB1	9
KEGG	hsa05220	Chronic myeloid leukemia	29/2327	76/8135	0.04503	0.2304	0.1924	GAB2/MAPK3/TGFB3/CDK6/STAT5A/TGFBR2/AKT2/ABL1/MAP2K1/MYC/SHC1/AKT3/BAK1/SOS1/GADD45B/NRAS/GADD45G/BAD/RUNX1/TGFBR1/HRAS/BRAF/SHC2/STAT5B/HDAC2/BCL2L1/BCR/CCND1/KRAS	29
KEGG	hsa00562	Inositol phosphate metabolism	28/2327	73/8135	0.04527	0.2304	0.1924	INPP4B/PI4K2A/ITPKB/IMPA2/MTMR1/MTMR3/INPP5A/MTMR14/PLCD3/PIP5K1A/MTMR4/IPMK/MTMR8/ALDH6A1/CDIPT/INPP1/PIK3C2B/PLCB2/MTMR2/PI4KA/SYNJ1/PLCH2/PLCD4/IMPA1/PLCG1/OCRL/IPPK/INPP5D	28
KEGG	hsa04720	Long-term potentiation	26/2327	67/8135	0.04558	0.2304	0.1924	MAPK3/ADCY8/ADCY1/GRIA1/MAP2K1/ATF4/RPS6KA3/CACNA1C/RAP1B/GRIN2A/GNAQ/NRAS/GRIN2D/PPP3CC/CAMK2A/PLCB2/HRAS/CREBBP/PPP1R1A/PRKCB/BRAF/ITPR2/ITPR1/RPS6KA1/KRAS/RAPGEF3	26
KEGG	hsa05205	Proteoglycans in cancer	70/2327	205/8135	0.04626	0.2304	0.1924	LUM/COL1A1/VAV3/MAPK3/ITGB3/FZD6/FGF2/MAPK12/ITGB1/VEGFA/SMO/ITGAV/WNT9B/SDC2/AKT2/TWIST2/FZD1/ITGB5/ITGA2/DCN/MAPK11/MAP2K1/THBS1/MYC/SDC4/AKT3/ERBB4/FZD10/PTCH1/ANK3/HSPB2/SOS1/HPSE/PTK2/FLNC/MMP2/FAS/ITGA5/NRAS/IGF1R/MET/CDC42/ROCK1/CAMK2A/HRAS/CTSL/TNF/PRKCB/BRAF/PDCD4/GPC3/TFAP4/FN1/RHOA/ITPR2/WNT9A/ITPR1/PLAUR/WNT5B/VTN/HGF/CTTN/FZD8/CCND1/PLCG1/KRAS/ERBB2/COL1A2/RRAS/IGF2	70
KEGG	hsa04810	Regulation of actin cytoskeleton	74/2327	218/8135	0.04691	0.2304	0.1924	FGF10/VAV3/ACTN1/MAPK3/ITGB3/FGF2/GSN/SSH1/PDGFC/ITGB1/PFN2/ITGAV/FGD1/LPAR1/EGF/MYL12B/MYL10/ACTR3C/ITGB5/ITGA2/MAP2K1/FGF9/F2R/PIP5K1A/WASL/ARHGAP35/FGF5/GNG12/FGF7/ARPC2/ITGA4/PDGFRB/SSH3/ENAH/VCL/ARPC5/SOS1/FGF1/PTK2/NCKAP1/PFN1/ACTR2/ITGA5/NRAS/CDC42/ARPC5L/ROCK1/FGF16/ARPC3/IQGAP2/HRAS/ITGA6/BDKRB2/WASF2/BRAF/FGFR4/FN1/RHOA/MYLK3/ITGB7/ITGB8/ITGB6/PDGFD/FGFR2/GNA12/APC2/PAK2/BRK1/FGF23/KRAS/RAC2/CXCR4/RRAS/ARPC1A	74
KEGG	hsa00640	Propanoate metabolism	14/2327	32/8135	0.04803	0.2325	0.1942	ACSS1/ACADS/LDHB/SUCLG2/ACACB/LDHA/HADHA/LDHAL6B/ALDH6A1/ECHDC1/ACSS3/MLYCD/ABAT/PCCA	14
KEGG	hsa05219	Bladder cancer	17/2327	41/8135	0.05256	0.2396	0.2001	CDH1/MAPK3/DAPK2/VEGFA/DAPK1/EGF/MAP2K1/THBS1/MYC/MMP2/NRAS/HRAS/BRAF/CCND1/KRAS/ERBB2/TYMP	17
KEGG	hsa05225	Hepatocellular carcinoma	58/2327	168/8135	0.05348	0.2396	0.2001	TXNRD1/SMARCA2/MAPK3/GSTO1/FZD6/SMARCC2/TGFB3/WNT9B/CDK6/LEF1/TGFBR2/LRP5/AKT2/FZD1/MAP2K1/MYC/DVL2/SHC1/AKT3/KEAP1/ARID2/FZD10/ARID1B/LRP6/BAK1/SOS1/GSTM4/GADD45B/GSTP1/GSTA1/SMARCE1/NRAS/IGF1R/MET/DPF1/GADD45G/FRAT1/BAD/TGFBR1/HRAS/MGST1/CSNK1A1/PRKCB/BRAF/SHC2/WNT9A/WNT5B/BCL2L1/MGST3/HGF/GSTM2/FZD8/APC2/CCND1/PLCG1/KRAS/IGF2/CSNK1A1L	58
KEGG	hsa00514	Other types of O-glycan biosynthesis	19/2327	47/8135	0.05409	0.2396	0.2001	GALNT16/GALNT7/GALNT15/XXYLT1/C1GALT1/B4GALT2/GALNT11/GALNT18/COLGALT2/LFNG/GALNT13/GXYLT2/EOGT/GALNT3/GALNT5/COLGALT1/GALNTL6/POGLUT1/C1GALT1C1	19
KEGG	hsa00620	Pyruvate metabolism	19/2327	47/8135	0.05409	0.2396	0.2001	ACSS1/PC/PCK2/LDHB/ACACB/LDHA/FH/ALDH3A2/LDHAL6B/ME2/ME3/ACYP1/ALDH1B1/ACAT1/GRHPR/ADH7/PDHB/PDHA1/DLAT	19
KEGG	hsa04979	Cholesterol metabolism	20/2327	50/8135	0.05453	0.2396	0.2001	APOE/APOC1/CYP27A1/ABCA1/NPC1/PLTP/STARD3/OSBPL5/NPC2/CD36/MYLIP/NCEH1/VDAC2/APOB/APOA1/VAPA/VDAC1/LIPG/SOAT1/ABCB11	20
KEGG	hsa05110	Vibrio cholerae infection	20/2327	50/8135	0.05453	0.2396	0.2001	TJP1/ATP6V1B2/ATP6V0A1/TCIRG1/SEC61B/ATP6V1G3/KDELR3/ATP6V1C1/SEC61G/SEC61A1/ATP6V1A/KDELR2/ATP6V0D1/CFTR/ARF1/ATP6V1F/ATP6V0E2/PLCG1/TJP2/ATP6V1E1	20
KEGG	hsa05144	Malaria	20/2327	50/8135	0.05453	0.2396	0.2001	IL6/IL12A/TGFB3/SDC2/CD40/THBS1/VCAM1/CD36/GYPC/IL1B/MET/TNF/MYD88/THBS4/CD81/KLRK1/CCL2/HBB/HGF/IL18	20
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	152/2327	476/8135	0.05547	0.2406	0.2009	NOX4/BDNF/ATG13/RAB39B/BCL2/MAPK3/IL6/DNAH6/AMBRA1/PTGS2/FZD6/MAPK12/UBE2J1/ZFYVE1/ATP2A3/SDHA/WNT9B/RPS27A/DNAH7/SLC25A4/DNAL4/XBP1/GPX3/LRP5/PIK3R4/FZD1/SPG11/DNALI1/PSMB7/MAP2K7/CSF1/MAPK11/GRIA1/MAP2K1/ATG2B/DKK1/RB1CC1/ATG2A/RAB5A/RYR2/PSMD12/ATF6/ATF4/DVL2/DNAH9/TUBB2A/CCS/EIF2S1/PRNP/CACNA1C/FZD10/CASP12/GRIN2A/PSMA5/MAP2K6/WDR41/VDAC2/PSMD8/CSNK2A1/PSMA4/ATG14/GNAQ/UBE2G2/LRP6/PSMD7/BAK1/EIF2AK3/PSMB5/CASP9/PSMB2/GPX8/PSMB1/MAP1LC3A/PSMA7/BID/WIPI1/ULK2/UCHL1/IL1B/FAS/IFT57/NDUFA12/NRAS/PARK7/GRIN2D/MAPT/KLC4/IL1A/HSPA5/PPP3CC/ULK1/PSMA3/FRAT1/PSMD6/CAMK2A/BAD/DCTN2/ATXN1L/PSMD14/KIF5C/HSD17B10/SMCR8/PLCB2/HRAS/NRBF2/NDUFA5/TNF/VDAC1/CSNK1A1/PSMD11/PRKCB/BRAF/GPX1/NDUFC1/WIPI2/UBA7/ATXN3/ALS2/ITPR2/HIP1/CDK5R1/TARDBP/WNT9A/ERN1/PSMC1/UQCRH/ITPR1/ATXN1/GRIA3/NDUFV3/WNT5B/BCL2L1/PSMC3/KLC1/PSMB4/DNAH1/CSNK2A3/FZD8/APC2/MAP1LC3C/PLCG1/KRAS/PSMA2/UBE2L3/COX7A2/LRRK2/NDUFB9/SDHB/CACNA1F/PSMD13/ATXN2L/CSNK1A1L	152
KEGG	hsa04966	Collecting duct acid secretion	12/2327	27/8135	0.05755	0.2464	0.2058	ATP6V1B2/ATP6V0A1/TCIRG1/SLC12A7/ATP6V1G3/ATP6V1C1/ATP6V1A/CA2/ATP6V0D1/ATP6V1F/ATP6V0E2/ATP6V1E1	12
KEGG	hsa05224	Breast cancer	51/2327	147/8135	0.06169	0.2608	0.2178	FGF10/MAPK3/FZD6/FGF2/NCOA3/WNT9B/CDK6/LEF1/LRP5/AKT2/EGF/FZD1/MAP2K1/FGF9/MYC/DVL2/PGR/SHC1/AKT3/FGF5/FGF7/FZD10/JAG1/NCOA1/LRP6/BAK1/SOS1/FGF1/GADD45B/NOTCH2/NRAS/IGF1R/FGF16/GADD45G/FRAT1/HRAS/CSNK1A1/BRAF/SHC2/WNT9A/DLL3/TNFSF11/WNT5B/FZD8/APC2/FGF23/CCND1/SP1/KRAS/ERBB2/CSNK1A1L	51
KEGG	hsa00512	Mucin type O-glycan biosynthesis	15/2327	36/8135	0.06363	0.2636	0.2201	GALNT16/GALNT7/GCNT3/GALNT15/C1GALT1/GALNT11/GALNT18/ST6GALNAC2/ST6GALNAC3/GALNT13/GALNT3/ST6GALNAC4/GALNT5/GALNTL6/C1GALT1C1	15
KEGG	hsa05215	Prostate cancer	35/2327	97/8135	0.06569	0.2636	0.2201	BCL2/CREB5/MAPK3/FOXO1/PDGFC/CREB3L4/CREB3L1/LEF1/HSP90AB1/CREB3/AKT2/EGF/IL1R2/MAP2K1/ATF4/AKT3/PLAT/PDGFRB/SOS1/CASP9/NKX3-1/ERG/GSTP1/NRAS/IGF1R/BAD/HRAS/CREBBP/BRAF/PDGFD/FGFR2/CCND1/KRAS/ERBB2/HSP90AA1	35
KEGG	hsa04935	Growth hormone synthesis, secretion and action	42/2327	119/8135	0.06573	0.2636	0.2201	CREB5/MAPK3/ADCY8/MAPK12/CREB3L4/CREB3L1/STAT5A/SSTR1/ADCY1/CREB3/AKT2/SOCS3/MAPK11/MAP2K1/MAP3K1/ATF4/ATF6B/SHC1/AKT3/STAT1/CACNA1C/MAP2K6/GNAQ/SOS1/PTK2/NRAS/IGFALS/PLCB2/HRAS/JUNB/CREBBP/GNAI3/PRKCB/SHC2/STAT5B/ITPR2/ITPR1/PLCG1/KRAS/GNAI2/CACNA1F/IRS2	42
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	71/2327	212/8135	0.06604	0.2636	0.2201	FGF10/ARRB1/BCL2/CREB5/MAPK3/ADCY8/GSTO1/FGF2/CREB3L4/VEGFA/AIP/CREB3L1/STAT5A/HSP90AB1/ADCY1/CREB3/AKT2/EGF/MIRLET7A2/EIF4EBP1/MAP2K1/FGF9/CYP1B1/MYC/ATF4/RPS6KA3/PGR/ATF6B/AKT3/KPNA3/FGF5/PPARA/FGF7/CACNA1C/JAG1/EPHX2/EPHX1/PAQR5/ARNT/SOS1/KPNA1/GSTM4/NOTCH2/KPNB1/ARRB2/GSTA1/NRAS/FGF16/KLF5/BAD/HRAS/MGST1/KPNA4/BCL6/GNAI3/PRKCB/STAT5B/RXRA/DLL3/PAQR8/TNFSF11/RPS6KA1/KPNA6/MGST3/GSTM2/CCND1/KRAS/GNAI2/CACNA1F/RXRG/HSP90AA1	71
KEGG	hsa00280	Valine, leucine and isoleucine degradation	19/2327	48/8135	0.06629	0.2636	0.2201	ACADS/OXCT1/AUH/BCAT1/ALDH3A2/HADHA/MCCC1/ALDH6A1/HMGCL/ALDH1B1/ACAT1/HIBADH/ABAT/OXCT2/HSD17B10/ACSF3/PCCA/AOX1/ACADM	19
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/2327	14/8135	0.07437	0.2922	0.2441	B4GALT2/B3GNT7/CHST2/FUT8/B4GALT4/CHST4/CHST6	7
KEGG	hsa04020	Calcium signaling pathway	79/2327	240/8135	0.07797	0.3028	0.2529	FGF10/ITPKB/MCOLN1/P2RX7/VEGFB/ADCY8/NGF/PDE1C/TPCN1/FGF2/TPCN2/PDGFC/ATP2A3/VEGFA/PDE1A/CAMK1D/NTRK3/EDNRB/SLC25A4/ADCY1/SLC8A1/MST1/AGTR1/EGF/PHKA2/PLCD3/FGF9/ORAI3/F2R/RYR2/PHKG1/MCOLN3/STIM1/FGF5/FGF7/CACNA1C/ERBB4/PDGFRB/GRIN2A/VDAC2/GNAQ/FGF1/TBXA2R/P2RX4/GNAL/ADORA2A/MET/GRIN2D/TNNC1/TNNC2/FGF16/PPP3CC/CAMK2A/GDNF/PLCB2/VDAC1/BDKRB2/ADRA1D/PRKCB/FGFR4/ITPR2/EDNRA/MYLK3/CASQ2/CACNA1E/ITPR1/PLCD4/PDGFD/FGFR2/OXTR/HGF/FGF23/PLCG1/PDE1B/ERBB2/ATP2B4/CXCR4/CACNA1F/P2RX5	79
KEGG	hsa01250	Biosynthesis of nucleotide sugars	15/2327	37/8135	0.07968	0.3046	0.2544	GFPT1/GFPT2/NANS/GALK2/GNPNAT1/HKDC1/UAP1L1/TGDS/PGM1/CMAS/PGM3/PMM2/NANP/GALT/PGM2	15
KEGG	hsa04931	Insulin resistance	38/2327	108/8135	0.08025	0.3046	0.2544	PPP1R3E/PRKAG3/CREB5/IL6/FOXO1/PCK2/CREB3L4/CREB3L1/GFPT1/PRKCZ/CREB3/AKT2/GFPT2/ACACB/SOCS3/NR1H3/TRIB3/PPP1R3B/RPS6KA3/AKT3/PPARA/MLXIP/CD36/PRKCE/CRTC2/PPARGC1A/INSR/NR1H2/PRKAB1/SLC2A1/SLC27A3/TNF/PRKCB/SREBF1/PPARGC1B/RPS6KA1/SLC2A4/IRS2	38
KEGG	hsa05414	Dilated cardiomyopathy	34/2327	96/8135	0.08688	0.3228	0.2696	LAMA2/ADCY8/ITGB3/ITGB1/ATP2A3/ITGAV/TGFB3/CACNA2D3/ADCY1/SLC8A1/CACNA2D4/SGCA/ITGB5/ITGA2/CACNA2D1/RYR2/DES/CACNA1C/DMD/ITGA4/TPM1/TTN/LAMA1/ITGA5/TNNC1/ITGA6/TNF/TPM2/ITGB7/ITGB8/ITGB6/MYL3/CACNA1F/CACNB1	34
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2327	20/8135	0.08778	0.3228	0.2696	CHST14/CHST15/CHST7/CHSY1/CSGALNACT1/CHST11/CHST12/B3GALT6/CHSY3	9
KEGG	hsa05323	Rheumatoid arthritis	33/2327	93/8135	0.0886	0.3228	0.2696	IL6/ANGPT1/VEGFA/TGFB3/ATP6V1B2/CTSK/ATP6V0A1/TCIRG1/CSF1/TNFSF13/ATP6V1G3/ATP6V1C1/HLA-DMA/TEK/IL23A/ACP5/ATP6V1A/IL1B/IL11/CXCL2/IL1A/ATP6V0D1/CTSL/TNF/CCL20/CCL2/TNFRSF11A/TNFSF11/ATP6V1F/CD80/ATP6V0E2/IL18/ATP6V1E1	33
KEGG	hsa00230	Purine metabolism	44/2327	128/8135	0.0889	0.3228	0.2696	AK7/PDE7A/ADCY8/PDE1C/FHIT/PDE4D/PDE1A/ENTPD4/AK5/ADCY1/PDE4B/GART/ENTPD3/AK9/DGUOK/GUK1/ADSL/AK2/LACC1/NTPCR/PAPSS2/NME4/ATIC/PAPSS1/ENTPD1/NME1/PNP/PGM1/AK8/PDE3A/NUDT5/XDH/IMPDH1/GUCY2C/PDE4A/AK4/GUCY2F/AK1/NPR2/HPRT1/PPAT/PGM2/IMPDH2/PDE1B	44
KEGG	hsa04370	VEGF signaling pathway	22/2327	59/8135	0.0928	0.3333	0.2783	MAPK3/PTGS2/MAPK12/VEGFA/AKT2/MAPK11/MAP2K1/AKT3/PLA2G4A/CASP9/PTK2/NRAS/CDC42/PPP3CC/BAD/HRAS/PRKCB/SHC2/PLCG1/PLA2G4C/KRAS/RAC2	22
KEGG	hsa04722	Neurotrophin signaling pathway	41/2327	119/8135	0.09491	0.3372	0.2817	BDNF/BCL2/MAPK3/NGF/MAPK12/RAPGEF1/MATK/NTRK3/PRDM4/IRAK1/AKT2/ABL1/MAP2K7/MAPK11/MAP2K1/MAP3K1/MAGED1/ATF4/RPS6KA3/TRAF6/SHC1/AKT3/MAP2K5/RAP1B/SH2B1/NTF3/SOS1/NRAS/CDC42/CAMK2A/BAD/RIPK2/HRAS/BRAF/SHC2/RHOA/MAP3K3/KIDINS220/RPS6KA1/PLCG1/KRAS	41
KEGG	hsa04137	Mitophagy - animal	26/2327	72/8135	0.1012	0.3521	0.2941	MITF/AMBRA1/RPS27A/TBC1D17/BCL2L13/ATF4/GABARAPL1/CSNK2A1/EIF2AK3/MAP1LC3A/CITED2/NRAS/ULK1/RHOT1/TFEB/HRAS/GABARAP/USP15/TBC1D15/BCL2L1/CSNK2A3/MAP1LC3C/USP30/SP1/KRAS/RRAS	26
KEGG	hsa04371	Apelin signaling pathway	47/2327	139/8135	0.1023	0.3521	0.2941	GNB5/CDH1/PRKAG3/MAPK3/ADCY8/GNG7/HDAC4/ADCY1/SLC8A1/AGTR1/AKT2/PIK3R4/MEF2A/MAP2K1/RYR2/MEF2C/AKT3/GNG12/PLAT/GNB4/PRKCE/KLF2/JAG1/PPARGC1A/HDAC5/GNAQ/MEF2D/MAP1LC3A/NRAS/SERPINE1/PRKAB1/TGFBR1/PLCB2/HRAS/GNB1/GNAI3/ITPR2/MYLK3/SPP1/ITPR1/MAP1LC3C/CCND1/GNB3/KRAS/GNAI2/MYL3/RRAS	47
KEGG	hsa05418	Fluid shear stress and atherosclerosis	47/2327	139/8135	0.1023	0.3521	0.2941	BCL2/ITGB3/GSTO1/MAPK12/VEGFA/ITGAV/ACVR2B/HSP90AB1/PRKCZ/SDC2/IL1R1/AKT2/IL1R2/ARHGEF2/MEF2A/ACVR1/MAP2K7/MAPK11/VCAM1/MEF2C/SDC4/AKT3/KEAP1/MAP2K5/EDN1/PLAT/KLF2/MAP2K6/PTK2/GSTM4/SUMO1/MMP2/IL1B/GSTP1/GSTA1/IL1A/MGST1/CTSL/TNF/RHOA/CCL2/MGST3/GSTM2/NCF2/RAC2/TXN/HSP90AA1	47
KEGG	hsa05131	Shigellosis	80/2327	247/8135	0.1039	0.353	0.2948	CYTH1/BCL2/ACTN1/MAPK3/FOXO1/MAPK12/ITGB1/PFN2/RPS27A/TLR5/IL1R1/TECPR1/ARF6/AKT2/PIK3R4/MYL12B/MYL10/ACTR3C/PLCD3/FOXO4/ARHGEF2/TAB1/MAPK11/WASL/CASP1/RRAGD/TRAF6/AKT3/TLN2/ARPC2/FNBP1/PRKCE/HKDC1/UBE2N/VCL/ARPC5/ATG14/TRADD/PTK2/UBE2V2/MAP1LC3A/PFN1/WIPI1/IL1B/ACTR2/ITGA5/CDC42/ARPC5L/CAST/ROCK1/ARPC3/UBE2D2/RIPK2/PLCB2/TNF/VDAC1/MYD88/CASP4/WASF2/ARF1/WIPI2/RHOA/ITPR2/CYTH3/ATG12/UBE2D3/ITPR1/PLCD4/CYTH2/BCL2L1/TRAF5/CTTN/MAP1LC3C/PLCG1/ELMO1/TLN1/IL18/FNBP1L/IRF3/ARPC1A	80
KEGG	hsa04210	Apoptosis	46/2327	136/8135	0.1046	0.353	0.2948	CTSC/BCL2/MAPK3/NGF/CTSH/BCL2L11/CTSF/SPTAN1/CTSK/AKT2/DFFA/PTPN13/BIRC3/MAP2K1/CTSO/BCL2A1/ATF4/AKT3/EIF2S1/AIFM1/CASP12/PARP4/HRK/BAK1/EIF2AK3/TRADD/CASP9/BID/GADD45B/FAS/NRAS/GADD45G/BAD/HRAS/CTSL/TNF/BIRC2/CSF2RB/ITPR2/ERN1/TNFRSF10B/ITPR1/PARP3/BCL2L1/DAB2IP/KRAS	46
KEGG	hsa04012	ErbB signaling pathway	30/2327	85/8135	0.1069	0.3534	0.2952	MAPK3/STAT5A/AKT2/EGF/ABL1/MAP2K7/EIF4EBP1/MAP2K1/MYC/SHC1/AKT3/ERBB4/SOS1/PTK2/NRAS/EREG/CAMK2A/BAD/HRAS/PRKCB/BRAF/SHC2/STAT5B/NCK2/ABL2/PAK2/PLCG1/KRAS/ERBB2/NRG1	30
KEGG	hsa04610	Complement and coagulation cascades	30/2327	85/8135	0.1069	0.3534	0.2952	CFI/C2/SERPINB2/SERPING1/F8/F2RL2/F2R/A2M/C7/PLAT/C8G/C1R/CFD/CFHR1/C1S/SERPINE1/PROS1/CFB/PROCR/BDKRB2/MBL2/MASP2/F10/F3/PROC/CD46/PLAUR/F7/VTN/VWF	30
KEGG	hsa04730	Long-term depression	22/2327	60/8135	0.1085	0.3552	0.2966	MAPK3/LYN/GRIA1/MAP2K1/PLA2G4A/GNAQ/NRAS/IGF1R/PLCB2/HRAS/PPP2R1A/GNAI3/PRKCB/BRAF/ITPR2/ITPR1/GRIA3/GNA12/GNAZ/PLA2G4C/KRAS/GNAI2	22
KEGG	hsa05134	Legionellosis	21/2327	57/8135	0.1102	0.3574	0.2985	IL6/IL12A/TLR5/HSPD1/CLK4/HSPA2/HSPA1A/HSPA6/BCL2L13/HSPA1B/CASP1/CLK1/HSPA8/SAR1A/CASP9/IL1B/CXCL2/TNF/MYD88/ARF1/IL18	21
KEGG	hsa05163	Human cytomegalovirus infection	73/2327	225/8135	0.1125	0.3613	0.3017	GNB5/PTGER4/CCR1/AKAP13/CREB5/MAPK3/IL6/ADCY8/ITGB3/CCR3/PTGS2/MAPK12/CREB3L4/VEGFA/CREB3L1/ITGAV/GNG7/TAPBP/CDK6/IL1R1/TSC2/ADCY1/CREB3/AKT2/MAPK11/EIF4EBP1/MAP2K1/HLA-E/MYC/ATF4/ATF6B/AKT3/GNG12/HLA-G/TSC1/GNB4/MAP2K6/GNAQ/BAK1/SOS1/TRADD/CASP9/PTK2/BID/IL1B/FAS/NRAS/IL6R/ROCK1/PPP3CC/PLCB2/HRAS/TNF/GNB1/GNAI3/PRKCB/RHOA/ITPR2/B2M/CCL2/ITPR1/HLA-C/GNA12/TRAF5/CCND1/GNB3/SP1/KRAS/GNAI2/RAC2/CXCR4/IRF3/ARHGEF11	73
KEGG	hsa05212	Pancreatic cancer	27/2327	76/8135	0.1137	0.3613	0.3017	MAPK3/PLD1/VEGFA/TGFB3/CDK6/TGFBR2/AKT2/EGF/MAP2K1/AKT3/STAT1/BAK1/CASP9/GADD45B/CDC42/GADD45G/BAD/TGFBR1/PLD2/RALB/BRAF/RALGDS/BCL2L1/CCND1/KRAS/RAC2/ERBB2	27
KEGG	hsa04611	Platelet activation	42/2327	124/8135	0.1147	0.3613	0.3017	FERMT3/COL1A1/MAPK3/ADCY8/ITGB3/MAPK12/ITGB1/PTGIR/FCGR2A/PRKCZ/TBXAS1/ADCY1/AKT2/MYL12B/ITGA2/LYN/VASP/MAPK11/F2R/STIM1/ARHGAP35/AKT3/TLN2/RAP1B/PLA2G4A/GNAQ/TBXA2R/ROCK1/PLCB2/APBB1IP/GNAI3/RHOA/ITPR2/MYLK3/ITPR1/SYK/VWF/P2RY1/PLA2G4C/GNAI2/TLN1/COL1A2	42
KEGG	hsa04917	Prolactin signaling pathway	25/2327	70/8135	0.1184	0.3669	0.3064	MAPK3/MAPK12/STAT5A/AKT2/SOCS3/SOCS5/MAPK11/MAP2K1/SHC1/AKT3/STAT1/SOS1/CYP17A1/NRAS/HRAS/SHC2/STAT5B/CCND2/TNFRSF11A/TNFSF11/PRL/CGA/GALT/CCND1/KRAS	25
KEGG	hsa01523	Antifolate resistance	12/2327	30/8135	0.1204	0.3669	0.3064	ABCC5/IL6/ABCC4/FOLR1/SHMT2/GART/ATIC/IL1B/MTHFR/TNF/ABCC2/ABCC1	12
KEGG	hsa05160	Hepatitis C	52/2327	157/8135	0.1207	0.3669	0.3064	MAPK3/CDK6/YWHAB/AKT2/EGF/CLDN11/SOCS3/IRF7/NR1H3/MAP2K1/IRF9/MYC/RSAD2/OAS1/TRAF6/AKT3/STAT1/EIF2S1/PPARA/CLDN23/IFIT1/CLDN4/STAT2/BAK1/SOS1/EIF2AK3/TRADD/CASP9/BID/PSME3/FAS/TRAF3/NRAS/PPP2R2C/MX1/OAS2/BAD/HRAS/PPP2R1A/TNF/CLDN1/YWHAZ/BRAF/EIF2AK4/CD81/RXRA/TLR3/OCLN/CLDN15/CCND1/KRAS/IRF3	52
KEGG	hsa05221	Acute myeloid leukemia	24/2327	67/8135	0.1208	0.3669	0.3064	MAPK3/PIM1/RUNX1T1/STAT5A/LEF1/AKT2/EIF4EBP1/MAP2K1/BCL2A1/MYC/AKT3/CEBPE/SOS1/NRAS/BAD/RUNX1/HRAS/JUP/BRAF/PPARD/STAT5B/RARA/CCND1/KRAS	24
KEGG	hsa04929	GnRH secretion	23/2327	64/8135	0.1232	0.3709	0.3097	ARRB1/GPER1/MAPK3/HCN2/AKT2/MAP2K1/KCNJ11/AKT3/CACNA1C/HCN3/GNAQ/GABBR2/ARRB2/NRAS/PLCB2/HRAS/PRKCB/ITPR2/SPP1/ITPR1/CGA/KRAS/CACNA1F	23
KEGG	hsa05213	Endometrial cancer	21/2327	58/8135	0.1281	0.3807	0.318	CDH1/MAPK3/LEF1/AKT2/EGF/MAP2K1/MYC/AKT3/BAK1/SOS1/CASP9/GADD45B/NRAS/GADD45G/BAD/HRAS/BRAF/APC2/CCND1/KRAS/ERBB2	21
KEGG	hsa04621	NOD-like receptor signaling pathway	60/2327	184/8135	0.1292	0.3807	0.318	BCL2/P2RX7/MAPK3/IL6/NEK7/GBP2/MAPK12/HSP90AB1/TNFAIP3/ANTXR1/GSDMD/IRF7/TAB1/MAPK11/BIRC3/ANTXR2/IRF9/OAS1/TRPM7/CASP1/TRAF6/STAT1/GABARAPL1/PSTPIP1/CASP12/STAT2/VDAC2/TRIP6/MAP1LC3A/DNM1L/IL1B/TRAF3/MEFV/CXCL2/IFI16/OAS2/RIPK2/PLCB2/TP53BP1/TNF/VDAC1/MYD88/SUGT1/CASP4/GABARAP/BIRC2/RHOA/ITPR2/ATG12/CCL2/ITPR1/GBP1/GBP3/BCL2L1/TRAF5/MAP1LC3C/IL18/TXN/IRF3/HSP90AA1	60
KEGG	hsa04912	GnRH signaling pathway	32/2327	93/8135	0.1299	0.3807	0.318	MAP3K4/MAPK3/ADCY8/PLD1/MAPK12/MMP14/ADCY1/MAP2K7/MAPK11/MAP2K1/MAP3K1/ATF4/CACNA1C/MAP2K6/PLA2G4A/GNAQ/SOS1/MMP2/NRAS/CDC42/CAMK2A/PLD2/PLCB2/HRAS/PRKCB/ITPR2/MAP3K3/ITPR1/CGA/PLA2G4C/KRAS/CACNA1F	32
KEGG	hsa05010	Alzheimer disease	120/2327	384/8135	0.1323	0.3842	0.3209	NOX4/ATG13/APOE/MAPK3/IL6/AMBRA1/PTGS2/FZD6/BACE1/ATP2A3/SDHA/WNT9B/SLC25A4/XBP1/APH1B/LRP5/AKT2/PIK3R4/FZD1/PSMB7/SLC39A1/MAP2K7/CSF1/MAP2K1/ATG2B/DKK1/RB1CC1/ATG2A/PSMD12/ATF6/ATF4/DVL2/TUBB2A/AKT3/EIF2S1/CACNA1C/FZD10/CASP12/GRIN2A/PSMA5/VDAC2/PSMD8/CSNK2A1/SLC39A2/PSMA4/ATG14/GNAQ/LRP6/PSMD7/EIF2AK3/PSMB5/CASP9/SLC39A7/PSMB2/INSR/PSMB1/PSMA7/BID/RTN3/WIPI1/ULK2/APBB1/IL1B/FAS/NDUFA12/NRAS/GRIN2D/MAPT/KLC4/IL1A/PPP3CC/ULK1/PSMA3/FRAT1/PSMD6/BAD/PSMD14/KIF5C/HSD17B10/PLCB2/HRAS/NRBF2/NDUFA5/TNF/VDAC1/SLC11A2/CSNK1A1/PSMD11/BRAF/IDE/NDUFC1/WIPI2/GAPDH/ADAM17/ITPR2/CDK5R1/WNT9A/ERN1/PSMC1/UQCRH/ITPR1/NDUFV3/WNT5B/PSMC3/KLC1/PSMB4/SLC39A8/CSNK2A3/FZD8/APC2/KRAS/PSMA2/COX7A2/NDUFB9/NAE1/SDHB/CACNA1F/PSMD13/IRS2/CSNK1A1L	120
KEGG	hsa00565	Ether lipid metabolism	18/2327	49/8135	0.1354	0.3889	0.3248	PLD1/TMEM189/ENPP6/ENPP2/AGPS/PAFAH1B1/CHPT1/PLA2G4A/GDPD3/PAFAH1B2/LPCAT4/LPCAT2/PLA2G7/PLD3/PLD2/PLA2G2A/PLA2G6/PLA2G4C	18
KEGG	hsa04926	Relaxin signaling pathway	43/2327	129/8135	0.1362	0.3889	0.3248	GNB5/ARRB1/COL1A1/CREB5/VEGFB/MAPK3/ADCY8/MAPK12/CREB3L4/VEGFA/CREB3L1/GNG7/EDNRB/PRKCZ/ADCY1/CREB3/TGFBR2/AKT2/MAP2K7/MAPK11/MAP2K1/ATF4/ATF6B/SHC1/AKT3/GNG12/EDN1/GNB4/SOS1/MMP2/ARRB2/NRAS/TGFBR1/PLCB2/HRAS/COL4A4/GNB1/GNAI3/SHC2/GNB3/KRAS/GNAI2/COL1A2	43
KEGG	hsa04213	Longevity regulating pathway - multiple species	22/2327	62/8135	0.1445	0.4009	0.3348	PRKAG3/FOXO1/ADCY8/ADCY1/AKT2/CRYAB/HSPA2/HSPA1A/HSPA6/HSPA1B/AKT3/EIF4EBP2/HSPA8/INSR/NRAS/PRKAB1/IGF1R/HRAS/HDAC2/KRAS/SOD2/IRS2	22
KEGG	hsa04530	Tight junction	55/2327	169/8135	0.145	0.4009	0.3348	TJP1/CGNL1/PRKAG3/LLGL1/ACTN1/ITGB1/MYL6B/PRKCZ/NEDD4/STK11/MYL12B/CLDN11/ACTR3C/VASP/ARHGEF2/MAP2K7/MAP3K1/RAB8B/DLG2/ARPC2/NEDD4L/CLDN23/DLG3/CLDN4/PRKCE/MPP4/EPB41L4B/ARPC5/ACTR2/DLG1/AMOT/PRKAB1/PPP2R2C/CDC42/RAPGEF6/ARPC5L/ROCK1/ARPC3/RAP2C/RUNX1/PPP2R1A/CFTR/CLDN1/RHOA/SLC9A3R1/OCLN/MPP5/MYL6/CTTN/CLDN15/CCND1/MPDZ/TJP2/ERBB2/ARPC1A	55
KEGG	hsa03020	RNA polymerase	13/2327	34/8135	0.146	0.4009	0.3348	POLR3D/POLR3G/POLR3B/CD3EAP/POLR1B/POLR3K/POLR3F/POLR2M/POLR2G/POLR3H/POLR3E/POLR1C/POLR2E	13
KEGG	hsa04721	Synaptic vesicle cycle	27/2327	78/8135	0.1461	0.4009	0.3348	CLTCL1/ATP6V1B2/ATP6V0A1/TCIRG1/CLTB/ATP6V1G3/SLC6A12/ATP6V1C1/UNC13A/SLC6A9/SLC1A7/AP2M1/ATP6V1A/SLC6A7/SLC18A2/AP2S1/ATP6V0D1/STX3/DNM2/RIMS1/ATP6V1F/CLTC/ATP6V0E2/NAPA/AP2A1/UNC13B/ATP6V1E1	27
KEGG	hsa04152	AMPK signaling pathway	40/2327	120/8135	0.1464	0.4009	0.3348	PRKAG3/CREB5/ADIPOR2/FOXO1/STRADB/PPARG/PCK2/CREB3L4/CREB3L1/RAB11B/TSC2/CREB3/AKT2/PFKFB2/STK11/ACACB/EIF4EBP1/AKT3/PPP2R3A/TSC1/CD36/CRTC2/PPARGC1A/MLYCD/INSR/EEF2K/PRKAB1/IGF1R/PPP2R2C/RAB10/ULK1/PPP2R1A/CFTR/FBP1/RAB2A/SREBF1/PPP2R5D/CCND1/SLC2A4/IRS2	40
KEGG	hsa00650	Butanoate metabolism	11/2327	28/8135	0.1486	0.4035	0.337	ACADS/OXCT1/ALDH5A1/HADHA/HMGCL/ACAT1/ACSM5/ABAT/ACSM3/OXCT2/BDH2	11
KEGG	hsa04064	NF-kappa B signaling pathway	35/2327	104/8135	0.1499	0.4038	0.3372	BCL2/PTGS2/TNFAIP3/IL1R1/IRAK1/CD40/LYN/EDA/TAB1/BIRC3/BCL2A1/VCAM1/LY96/TRAF6/LTBR/LBP/CSNK2A1/TRADD/IL1B/GADD45B/TRAF3/CXCL2/GADD45G/TNF/MYD88/PRKCB/BIRC2/SYK/TNFRSF11A/TNFSF11/BCL2L1/RELB/TRAF5/CSNK2A3/PLCG1	35
KEGG	hsa04962	Vasopressin-regulated water reabsorption	16/2327	44/8135	0.1644	0.4393	0.3669	STX4/CREB5/CREB3L4/CREB3L1/RAB11B/CREB3/AQP3/RAB5A/DYNLL2/DYNC2H1/DYNC2LI1/DCTN2/AVPR2/RAB11A/DYNC1LI2/DYNC1LI1	16
KEGG	hsa05210	Colorectal cancer	29/2327	86/8135	0.1742	0.46	0.3841	BCL2/MAPK3/BCL2L11/TGFB3/LEF1/TGFBR2/AKT2/EGF/MAP2K1/MYC/AKT3/BAK1/SOS1/CASP9/GADD45B/NRAS/GADD45G/EREG/BAD/TGFBR1/RALB/HRAS/BRAF/RHOA/RALGDS/APC2/CCND1/KRAS/RAC2	29
KEGG	hsa05230	Central carbon metabolism in cancer	24/2327	70/8135	0.1771	0.46	0.3841	MAPK3/SLC7A5/SIRT3/NTRK3/LDHB/AKT2/LDHA/MAP2K1/MYC/AKT3/SLC1A5/LDHAL6B/PDGFRB/HKDC1/SLC16A3/NRAS/MET/SLC2A1/HRAS/PDHB/FGFR2/PDHA1/KRAS/ERBB2	24
KEGG	hsa04136	Autophagy - other	12/2327	32/8135	0.1776	0.46	0.3841	ATG13/PIK3R4/ATG2B/ATG2A/GABARAPL1/WIPI1/ULK2/GABARAP/WIPI2/ATG7/ATG12/ATG3	12
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	36/2327	109/8135	0.1776	0.46	0.3841	NOP10/RIOK1/GNL3/WDR43/EIF6/GTPBP4/NXT1/WDR3/XRN2/NXF1/UTP6/NOP56/UTP14A/RPP40/BMS1/IMP4/DKC1/CSNK2A1/EMG1/HEATR1/GNL3L/REXO2/RAN/NAT10/WDR75/XRN1/NOP58/NOL6/RIOK2/UTP15/GAR1/RPP38/MPHOSPH10/GNL2/CSNK2A3/NHP2	36
KEGG	hsa00010	Glycolysis / Gluconeogenesis	23/2327	67/8135	0.1817	0.4636	0.3872	GALM/ACSS1/PCK2/LDHB/LDHA/ALDH3A2/LDHAL6B/HKDC1/ALDH1B1/PGM1/BPGM/ADH7/PDHB/FBP1/GAPDH/ENO4/ALDOC/ENO2/PDHA1/PGM2/DLAT/ALDH3B1/ENO1	23
KEGG	hsa05161	Hepatitis B	52/2327	162/8135	0.1818	0.4636	0.3872	BCL2/CREB5/MAPK3/IL6/MAPK12/CREB3L4/CREB3L1/TGFB3/STAT5A/IRAK1/CREB3/TGFBR2/YWHAB/AKT2/IRF7/MAP2K7/TAB1/MAPK11/MAP2K1/MAP3K1/MYC/ATF4/ATF6B/TRAF6/AKT3/STAT1/STAT6/EGR2/CASP12/STAT2/MAP2K6/SOS1/CASP9/BID/FAS/TRAF3/NRAS/BAD/TGFBR1/HRAS/TNF/MYD88/CREBBP/STAT4/YWHAZ/PRKCB/BRAF/IFIH1/STAT5B/TLR3/KRAS/IRF3	52
KEGG	hsa05162	Measles	45/2327	139/8135	0.1841	0.4658	0.3891	BCL2/IL6/IL12A/CDK6/STAT5A/TNFAIP3/IRAK1/AKT2/HSPA2/IRF7/HSPA1A/HSPA6/IRF9/HSPA1B/OAS1/TRAF6/AKT3/STAT1/EIF2S1/STAT2/HSPA8/CSNK2A1/BAK1/EIF2AK3/TRADD/CASP9/BID/IL1B/FAS/TRAF3/MX1/IL1A/OAS2/BAD/TLR7/MYD88/IFIH1/EIF2AK4/STAT5B/CCND2/CD46/BCL2L1/CSNK2A3/CCND1/IRF3	45
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	48/2327	150/8135	0.2001	0.4994	0.4171	BCL2/CREB5/MAPK3/ADCY8/MAPK12/CREB3L4/ATP2A3/CREB3L1/CACNA2D3/ATP1A2/ADCY1/SLC8A1/CREB3/AGTR1/AKT2/CACNA2D4/SCN5A/CREM/MAPK11/SCN1B/CACNA2D1/RYR2/ATP1A3/ATF4/ATF6B/AKT3/PPP2R3A/CACNA1C/TPM1/GNAQ/PPP2R2C/ATP1B2/TNNC1/CAMK2A/PLCB2/PPP2R1A/ATP1A1/PPP1R1A/ADRA1D/GNAI3/TPM2/PPP2R5D/GNAI2/RAPGEF3/ATP2B4/MYL3/CACNA1F/CACNB1	48
KEGG	hsa00513	Various types of N-glycan biosynthesis	14/2327	39/8135	0.2004	0.4994	0.4171	MAN1A1/ALG2/B4GALNT3/B4GALT2/FUT8/MAN1C1/ALG12/HEXA/MGAT4C/HEXB/STT3A/MGAT4A/MAN2A2/DAD1	14
KEGG	hsa04664	Fc epsilon RI signaling pathway	23/2327	68/8135	0.2039	0.5045	0.4214	GAB2/VAV3/MAPK3/MAPK12/AKT2/LYN/MAP2K7/MAPK11/MAP2K1/ALOX5AP/AKT3/MAP2K6/PLA2G4A/SOS1/NRAS/HRAS/TNF/SYK/PLCG1/PLA2G4C/KRAS/RAC2/INPP5D	23
KEGG	hsa04916	Melanogenesis	33/2327	101/8135	0.2104	0.5166	0.4315	MITF/MAPK3/ADCY8/FZD6/TYR/CREB3L4/CREB3L1/WNT9B/EDNRB/LEF1/ADCY1/CREB3/FZD1/MAP2K1/DVL2/DCT/EDN1/FZD10/KITLG/GNAQ/NRAS/CAMK2A/PLCB2/HRAS/CREBBP/GNAI3/PRKCB/WNT9A/WNT5B/FZD8/KRAS/GNAI2/MC1R	33
KEGG	hsa01230	Biosynthesis of amino acids	25/2327	75/8135	0.2151	0.5214	0.4355	CTH/GPT2/PC/ALDH18A1/TALDO1/PYCR1/PSAT1/ASNS/CBS/SHMT2/PSPH/BCAT1/RPE/GOT1/IDH3A/PYCR2/GOT2/GAPDH/ENO4/PHGDH/GLUL/SDS/ALDOC/ENO2/ENO1	25
KEGG	hsa00020	Citrate cycle (TCA cycle)	11/2327	30/8135	0.2154	0.5214	0.4355	PC/PCK2/SDHA/SUCLG2/FH/OGDHL/IDH3A/PDHB/PDHA1/DLAT/SDHB	11
KEGG	hsa04330	Notch signaling pathway	20/2327	59/8135	0.2216	0.5324	0.4447	TLE1/APH1B/DVL2/JAG1/MAML1/DTX3L/NOTCH2/MAML3/LFNG/NUMB/DTX2/ATXN1L/TLE4/NCOR2/MAML2/CREBBP/ADAM17/HDAC2/ATXN1/DLL3	20
KEGG	hsa04977	Vitamin digestion and absorption	9/2327	24/8135	0.2255	0.5349	0.4467	LMBRD1/SLC19A3/BTD/APOB/APOA1/FOLH1/TCN2/ABCC1/SLC23A1	9
KEGG	hsa05169	Epstein-Barr virus infection	63/2327	202/8135	0.227	0.5349	0.4467	BCL2/IL6/MAPK12/BCL2L11/TAPBP/CDK6/TNFAIP3/IRAK1/AKT2/NEDD4/CD40/IRF7/LYN/MAP2K7/TAB1/MAPK11/ENTPD3/HLA-E/IRF9/MYC/PSMD12/SAP30L/OAS1/TRAF6/AKT3/STAT1/HLA-G/HLA-DMA/STAT2/MAP2K6/PSMD8/ENTPD1/PSMD7/BAK1/TRADD/CASP9/BID/GADD45B/FAS/TRAF3/USP7/GADD45G/OAS2/PSMD6/PSMD14/NCOR2/TNF/MYD88/PSMD11/HDAC2/B2M/PSMC1/CCND2/SAP30/SYK/HLA-C/PSMC3/RELB/TRAF5/CCND1/CD19/IRF3/PSMD13	63
KEGG	hsa05211	Renal cell carcinoma	23/2327	69/8135	0.2274	0.5349	0.4467	MAPK3/VEGFA/RAPGEF1/TGFB3/AKT2/MAP2K1/FH/AKT3/RAP1B/ARNT/SOS1/EGLN2/NRAS/MET/CDC42/SLC2A1/BAD/HRAS/CREBBP/BRAF/HGF/PAK2/KRAS	23
KEGG	hsa04972	Pancreatic secretion	33/2327	102/8135	0.2298	0.5366	0.4482	BST1/CPB1/ADCY8/TPCN2/ATP2A3/PRSS3/RAB27B/ATP1A2/ADCY1/RYR2/ATP1A3/CLCA1/RAP1B/GNAQ/CLCA2/ATP1B2/KCNMA1/CA2/RAB3D/CEL/SLC4A4/AMY2B/PLCB2/PLA2G2A/CFTR/ATP1A1/PRKCB/RAB11A/RHOA/ITPR2/ITPR1/SCTR/ATP2B4	33
KEGG	hsa04728	Dopaminergic synapse	42/2327	132/8135	0.2318	0.5378	0.4491	GNB5/ARRB1/CREB5/MAPK12/CREB3L4/CREB3L1/GNG7/CREB3/AKT2/MAPK11/GRIA1/ATF4/ATF6B/AKT3/GNG12/PPP2R3A/CACNA1C/GNB4/GRIN2A/LRTOMT/GNAQ/GNAL/ARRB2/DRD2/PPP2R2C/SLC18A2/PPP3CC/CAMK2A/KIF5C/PLCB2/CLOCK/PPP2R1A/GNB1/GNAI3/PRKCB/ITPR2/ITPR1/GRIA3/PPP2R5D/GNB3/ARNTL/GNAI2	42
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	18/2327	53/8135	0.2346	0.5405	0.4514	ATP1A2/CLTCL1/SLC8A1/CLTB/ATP1A3/GNAQ/AP2M1/ATP1B2/AP2S1/PLCB2/BDKRB2/DNM2/ATP1A1/PRKCB/RAB11A/CLTC/ATP2B4/AP2A1	18
KEGG	hsa05217	Basal cell carcinoma	21/2327	63/8135	0.2408	0.5509	0.4601	FZD6/GLI3/SMO/WNT9B/LEF1/SUFU/FZD1/BMP2/HHIP/DVL2/GLI2/FZD10/PTCH1/BAK1/GADD45B/PTCH2/GADD45G/WNT9A/WNT5B/FZD8/APC2	21
KEGG	hsa00410	beta-Alanine metabolism	11/2327	31/8135	0.2528	0.5744	0.4797	ACADS/ALDH3A2/HADHA/ALDH6A1/ALDH1B1/MLYCD/ABAT/SMOX/CSAD/ALDH3B1/DPYD	11
KEGG	hsa04022	cGMP-PKG signaling pathway	52/2327	167/8135	0.2572	0.5799	0.4843	CREB5/MAPK3/ADCY8/CREB3L4/ATP2A3/CREB3L1/ATP1A2/EDNRB/SLC25A4/ADCY1/SLC8A1/CREB3/AGTR1/AKT2/VASP/MEF2A/MAP2K1/ATP1A3/ATF4/MEF2C/ATF6B/AKT3/CACNA1C/PRKCE/VDAC2/GNAQ/MEF2D/INSR/ATP1B2/KCNMA1/PDE3A/ROCK1/PPP3CC/BAD/PLCB2/VDAC1/BDKRB2/ATP1A1/RGS2/ADRA1D/GNAI3/RHOA/ITPR2/EDNRA/MYLK3/ITPR1/NPR2/GNA12/GNAI2/ATP2B4/CACNA1F/IRS2	52
KEGG	hsa04390	Hippo signaling pathway	49/2327	157/8135	0.2587	0.5799	0.4843	CDH1/LLGL1/FZD6/TEAD1/FRMD6/TGFB3/AJUBA/WNT9B/LEF1/PRKCZ/TP53BP2/TGFBR2/YWHAB/FZD1/GDF5/TEAD2/LIMD1/BMP2/BIRC3/MYC/DLG2/DVL2/DLG5/BMP6/DLG3/GLI2/FZD10/WTIP/AFP/FGF1/DLG1/SERPINE1/AMOT/PPP2R2C/TGFBR1/PPP2R1A/YWHAZ/BIRC2/TEAD4/WNT9A/CCND2/MPP5/WNT5B/SNAI2/FZD8/APC2/CCND1/LATS1/SMAD1	49
KEGG	hsa04922	Glucagon signaling pathway	34/2327	107/8135	0.2637	0.5872	0.4905	PRKAG3/CREB5/FOXO1/PCK2/CREB3L4/CREB3L1/SIK2/LDHB/CREB3/AKT2/PHKA2/ACACB/LDHA/PHKG1/ATF4/AKT3/PPARA/LDHAL6B/CRTC2/PPARGC1A/GNAQ/PRKAB1/SLC2A1/PPP3CC/PRMT1/CAMK2A/PLCB2/PDHB/CREBBP/FBP1/ITPR2/PPP4C/ITPR1/PDHA1	34
KEGG	hsa04724	Glutamatergic synapse	36/2327	114/8135	0.2702	0.5952	0.4971	GNB5/SLC38A1/SLC38A2/MAPK3/ADCY8/PLD1/SHANK2/GNG7/ADCY1/GRIK5/GRIA1/GNG12/CACNA1C/GNB4/GRIN2A/SLC1A7/GRIK1/PLA2G4A/GNAQ/GRIN2D/PPP3CC/GRM8/PLD2/PLCB2/GNB1/GNAI3/PRKCB/GLUL/ITPR2/GRM3/ITPR1/GRIA3/GNB3/PLA2G4C/GNAI2/SHANK1	36
KEGG	hsa04620	Toll-like receptor signaling pathway	33/2327	104/8135	0.2709	0.5952	0.4971	MAPK3/IL6/IL12A/MAPK12/TLR5/CTSK/IRAK1/AKT2/CD40/IRF7/MAP2K7/TAB1/MAPK11/MAP2K1/MAP3K8/LY96/TRAF6/AKT3/STAT1/TLR1/MAP2K6/LBP/IL1B/TRAF3/TOLLIP/TLR7/TNF/MYD88/SPP1/TLR3/TLR8/CD80/IRF3	33
KEGG	hsa00561	Glycerolipid metabolism	20/2327	61/8135	0.2756	0.6015	0.5024	AGPAT4/MBOAT1/LPIN3/PNPLA2/ALDH3A2/DGKH/GK/DGAT1/ALDH1B1/LPIN1/DGKE/LCLAT1/GPAM/CEL/DGKA/PNLIPRP3/DGKG/LPIN2/LIPG/GPAT2	20
KEGG	hsa01200	Carbon metabolism	36/2327	115/8135	0.2907	0.6296	0.5258	ACSS1/GPT2/ACADS/PC/SDHA/TALDO1/PSAT1/GLUD2/SUCLG2/SHMT2/PSPH/FH/RPE/OGDHL/GOT1/ME2/HKDC1/ALDH6A1/ME3/ACAT1/IDH3A/PDHB/GOT2/FBP1/PCCA/GAPDH/H6PD/ENO4/PHGDH/SDS/ALDOC/ENO2/PDHA1/DLAT/SDHB/ENO1	36
KEGG	hsa04215	Apoptosis - multiple species	11/2327	32/8135	0.2922	0.6296	0.5258	BCL2/BCL2L11/BIRC7/BIRC3/BOK/BAK1/CASP9/BID/BIRC2/BIRC6/BCL2L1	11
KEGG	hsa00430	Taurine and hypotaurine metabolism	6/2327	16/8135	0.2949	0.6315	0.5274	FMO5/FMO4/FMO3/GGT7/CSAD/FMO2	6
KEGG	hsa00920	Sulfur metabolism	4/2327	10/8135	0.3135	0.667	0.557	SELENBP1/PAPSS2/PAPSS1/TST	4
KEGG	hsa05133	Pertussis	24/2327	76/8135	0.3217	0.6801	0.568	C2/MAPK3/IL6/IL12A/MAPK12/ITGB1/SERPING1/IRAK1/MAPK11/LY96/CASP1/TRAF6/C1R/IL23A/C1S/IL1B/ITGA5/IL1A/TNF/MYD88/GNAI3/RHOA/GNAI2/IRF3	24
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	8/2327	23/8135	0.3258	0.6844	0.5716	PCK2/ATP1A2/GLUD2/ATP1A3/ATP1B2/CA2/SLC4A4/ATP1A1	8
KEGG	hsa01524	Platinum drug resistance	23/2327	73/8135	0.3315	0.6877	0.5744	BCL2/SLC31A1/MAPK3/GSTO1/AKT2/BIRC3/AKT3/BAK1/CASP9/GSTM4/BID/GSTP1/FAS/GSTA1/BAD/MGST1/ABCC2/ERCC1/BIRC2/BCL2L1/MGST3/GSTM2/ERBB2	23
KEGG	hsa04115	p53 signaling pathway	23/2327	73/8135	0.3315	0.6877	0.5744	BCL2/SESN2/CD82/CDK6/TSC2/CCNG2/THBS1/PPM1D/SHISA5/SESN3/CASP9/BID/GADD45B/FAS/SERPINE1/GADD45G/EI24/CCNG1/TNFRSF10B/CCND2/GORAB/BCL2L1/CCND1	23
KEGG	hsa00310	Lysine degradation	20/2327	63/8135	0.3337	0.6879	0.5745	PRDM6/SETDB2/DHTKD1/SETMAR/ALDH3A2/HADHA/PRDM2/AASS/KMT2E/ALDH1B1/ACAT1/KMT2C/EHMT2/SETD1A/COLGALT2/PLOD2/NSD1/COLGALT1/BBOX1/EZH1	20
KEGG	hsa00100	Steroid biosynthesis	7/2327	20/8135	0.3391	0.6948	0.5803	HSD17B7/SC5D/CYP24A1/DHCR24/CEL/CYP27B1/SOAT1	7
KEGG	hsa05202	Transcriptional misregulation in cancer	58/2327	193/8135	0.3524	0.7161	0.5981	CDK14/MITF/IL6/FOXO1/PPARG/KDM6A/RUNX1T1/HOXA10/CEBPB/TGFBR2/SIX4/CD40/IL1R2/CDK9/RUNX2/BIRC3/FUT8/BCL2A1/MYC/KLF3/MEF2C/MAF/PLAT/BMP2K/CEBPE/LDB1/BAK1/PTK2/ERG/HOXA9/ATF1/GADD45B/TSPAN7/IGF1R/MET/GADD45G/MLLT3/RUNX1/AFF1/BCL11B/JUP/BCL6/BIRC2/HPGD/HDAC2/ITGB7/PROM1/RXRA/CCND2/GRIA3/RARA/BCL2L1/ELANE/MEN1/SP1/RXRG/NCOR1/SMAD1	58
KEGG	hsa00450	Selenocompound metabolism	6/2327	17/8135	0.3538	0.7161	0.5981	CTH/TXNRD1/PAPSS2/INMT/PAPSS1/SEPSECS	6
KEGG	hsa01212	Fatty acid metabolism	18/2327	57/8135	0.3559	0.7162	0.5981	ACADS/CPT2/TECR/ELOVL3/HADHA/PPT2/ELOVL6/ELOVL1/ACAT1/HSD17B8/HSD17B12/ACSF3/ELOVL5/SCP2/CBR4/OXSM/ACSL6/ACADM	18
KEGG	hsa04120	Ubiquitin mediated proteolysis	43/2327	142/8135	0.3581	0.7162	0.5981	RHOBTB2/UBE2J1/RPS27A/MID1/HERC1/NEDD4/SOCS3/UBE2U/UBR5/BIRC7/BIRC3/UBE2K/MAP3K1/TRAF6/KEAP1/CUL4A/NEDD4L/UBE2N/UBE2Z/UBE4B/UBE2H/UBE2G2/ANAPC10/HERC4/UBE2E3/UBE2D2/UBE2Q2/RNF7/UBOX5/BIRC2/UBA7/SMURF2/HUWE1/UBE2E2/BIRC6/UBE2D3/CUL7/ANAPC1/SMURF1/TRIP12/CUL5/ITCH/UBE2L3	43
KEGG	hsa00062	Fatty acid elongation	9/2327	27/8135	0.3603	0.7163	0.5983	TECR/ELOVL3/HADHA/PPT2/ELOVL6/ELOVL1/ACOT7/HSD17B12/ELOVL5	9
KEGG	hsa01522	Endocrine resistance	30/2327	98/8135	0.3655	0.7224	0.6033	GPER1/BCL2/MAPK3/ADCY8/MAPK12/NCOA3/ADCY1/AKT2/MAPK11/MAP2K1/SHC1/AKT3/JAG1/SOS1/PTK2/MMP2/NOTCH2/NRAS/IGF1R/BAD/HRAS/BRAF/SHC2/DLL3/CCND1/SP1/KRAS/ABCB11/ERBB2/NCOR1	30
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	58/2327	194/8135	0.3698	0.7266	0.6068	GNB5/CCR1/MAPK3/IL6/CCR3/PTGS2/FGF2/MAPK12/VEGFA/HCK/GNG7/RPS27A/CDK6/LEF1/AKT2/CLEC2B/IRF7/LYN/ZFP36/MAP2K7/MAPK11/MAP2K1/HLA-E/IRF9/MYC/AKT3/STAT1/GNG12/HLA-G/GNB4/STAT2/MAP2K6/ATG14/BAK1/TRADD/CASP9/MAP1LC3A/BID/FAS/TRAF3/NRAS/CXCL2/PPP3CC/HRAS/CREBBP/GNB1/ITPR2/TLR3/ITPR1/SYK/HLA-C/MAP1LC3C/CCND1/PLCG1/GNB3/KRAS/IRF3/ATG3	58
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2327	24/8135	0.376	0.7343	0.6133	HS2ST1/NDST1/EXT1/EXTL2/HS3ST2/NDST3/HS3ST3B1/B3GALT6	8
KEGG	hsa04918	Thyroid hormone synthesis	23/2327	75/8135	0.3878	0.7452	0.6224	CREB5/ADCY8/CREB3L4/CREB3L1/ATP1A2/ADCY1/GPX3/CREB3/ATP1A3/ATF4/ATF6B/GNAQ/GPX8/ATP1B2/HSPA5/PLCB2/ATP1A1/PRKCB/GPX1/ITPR2/GSR/ITPR1/CGA	23
KEGG	hsa05214	Glioma	23/2327	75/8135	0.3878	0.7452	0.6224	MAPK3/CDK6/CAMK1D/AKT2/EGF/MAP2K1/SHC1/AKT3/PDGFRB/BAK1/SOS1/GADD45B/NRAS/IGF1R/GADD45G/CAMK2A/HRAS/PRKCB/BRAF/SHC2/CCND1/PLCG1/KRAS	23
KEGG	hsa00240	Pyrimidine metabolism	18/2327	58/8135	0.3882	0.7452	0.6224	DCTD/UCK2/ENTPD4/ENTPD3/AK9/CTPS1/UCK1/CMPK1/UMPS/NME4/ENTPD1/NME1/CDA/CMPK2/CTPS2/DCTPP1/DPYD/TYMP	18
KEGG	hsa04927	Cortisol synthesis and secretion	20/2327	65/8135	0.3944	0.7528	0.6287	NR0B1/CREB5/ADCY8/CREB3L4/CREB3L1/ADCY1/CREB3/AGTR1/ATF4/ATF6B/CACNA1C/KCNK2/NCEH1/GNAQ/CYP17A1/PLCB2/ITPR2/ITPR1/SP1/CACNA1F	20
KEGG	hsa04924	Renin secretion	21/2327	69/8135	0.4122	0.7799	0.6513	PTGER4/PDE1C/PDE1A/AGTR1/CLCA1/CACNA1C/EDN1/GNAQ/KCNJ2/CLCA2/KCNMA1/PDE3A/PPP3CC/PLCB2/GNAI3/ITPR2/EDNRA/ITPR1/PDE1B/GNAI2/CACNA1F	21
KEGG	hsa00061	Fatty acid biosynthesis	6/2327	18/8135	0.4133	0.7799	0.6513	ACACB/HSD17B8/ACSF3/CBR4/OXSM/ACSL6	6
KEGG	hsa04670	Leukocyte transendothelial migration	34/2327	114/8135	0.4208	0.7897	0.6595	VAV3/ACTN1/MAPK12/ITGB1/MYL12B/MYL10/CLDN11/VASP/MAPK11/VCAM1/SIPA1/ARHGAP35/CLDN23/ITGA4/RAP1B/CLDN4/VCL/PTK2/MMP2/CDC42/ROCK1/THY1/CLDN1/GNAI3/PRKCB/RHOA/OCLN/CLDN15/PLCG1/NCF2/GNAI2/RAPGEF3/RAC2/CXCR4	34
KEGG	hsa04380	Osteoclast differentiation	38/2327	128/8135	0.4255	0.7916	0.6611	GAB2/TNFRSF11B/MITF/MAPK3/ITGB3/PPARG/MAPK12/FHL2/FCGR2A/CTSK/IL1R1/TGFBR2/AKT2/SOCS3/MAP2K7/TAB1/CSF1/MAPK11/MAP2K1/IRF9/TRAF6/AKT3/STAT1/STAT2/MAP2K6/FOSL2/ACP5/IL1B/IL1A/PPP3CC/TGFBR1/JUNB/TNF/SYK/TNFRSF11A/TNFSF11/RELB/NCF2	38
KEGG	hsa04936	Alcoholic liver disease	42/2327	142/8135	0.4295	0.7916	0.6611	NOX4/C2/PRKAG3/ADIPOR2/IL6/FOXO1/IL12A/MAPK12/LEF1/IRAK1/AKT2/ACACB/MAP2K7/TAB1/MAPK11/LPIN3/LY96/ALDH3A2/TRAF6/AKT3/PPARA/MAP2K6/PPARGC1A/ALDH1B1/LBP/LPIN1/TRADD/MLYCD/IL1B/FAS/TRAF3/PRKAB1/CXCL2/ADH7/TNF/MYD88/SREBF1/LPIN2/TRA2B/CCND1/IRF3/ACADM	42
KEGG	hsa05030	Cocaine addiction	15/2327	49/8135	0.4305	0.7916	0.6611	BDNF/CREB5/CREB3L4/CREB3L1/CREB3/ATF4/ATF6B/GRIN2A/DRD2/SLC18A2/GRIN2D/GNAI3/GRM3/CDK5R1/GNAI2	15
KEGG	hsa04514	Cell adhesion molecules	44/2327	149/8135	0.4313	0.7916	0.6611	NLGN1/CDH1/ITGB1/NLGN4X/ITGAV/NRCAM/ALCAM/CNTN1/CD276/SDC2/SELL/NCAM2/CLDN11/CD40/PVR/HLA-E/VCAN/VCAM1/SDC4/CADM1/CD274/HLA-G/CLDN23/ITGA4/HLA-DMA/CLDN4/CDH2/CADM3/CD226/NTNG1/ITGA6/NLGN3/ICAM2/CLDN1/MPZL1/ITGB7/ITGB8/OCLN/HLA-C/PTPRC/CLDN15/CD80/CD34/NCAM1	44
KEGG	hsa05416	Viral myocarditis	18/2327	60/8135	0.4536	0.8257	0.6896	LAMA2/SGCA/ABL1/CD40/HLA-E/CXADR/HLA-G/DMD/HLA-DMA/CASP9/BID/LAMA1/ABL2/HLA-C/EIF4G1/CD80/CCND1/RAC2	18
KEGG	hsa04392	Hippo signaling pathway - multiple species	9/2327	29/8135	0.4549	0.8257	0.6896	TEAD1/FRMD6/AJUBA/TEAD2/LIMD1/WTIP/FAT4/TEAD4/LATS1	9
KEGG	hsa04940	Type I diabetes mellitus	13/2327	43/8135	0.4635	0.8369	0.6989	IL12A/HSPD1/HLA-E/CPE/HLA-G/HLA-DMA/PTPRN2/IL1B/FAS/IL1A/TNF/HLA-C/CD80	13
KEGG	hsa00510	N-Glycan biosynthesis	15/2327	50/8135	0.4665	0.8376	0.6996	MAN1A1/ALG2/DPM1/B4GALT2/FUT8/MAN1C1/ALG12/MGAT4C/STT3A/MGAT4A/MAN2A2/ALG5/DAD1/DPAGT1/MOGS	15
KEGG	hsa04910	Insulin signaling pathway	40/2327	137/8135	0.4711	0.8414	0.7028	PPP1R3E/PRKAG3/SORBS1/MAPK3/FOXO1/PCK2/RAPGEF1/INPP5A/PRKCZ/TSC2/AKT2/PHKA2/ACACB/SOCS3/EIF4EBP1/MAP2K1/PPP1R3B/PHKG1/SHC1/AKT3/TSC1/HKDC1/PPARGC1A/SOS1/INSR/NRAS/PRKAB1/EIF4E2/BAD/HRAS/MKNK2/FBP1/BRAF/SREBF1/SHC2/RHOQ/EIF4E/KRAS/SLC2A4/IRS2	40
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/2327	26/8135	0.4766	0.8423	0.7035	PIGQ/GPAA1/PIGT/MPPE1/GPLD1/PIGC/PIGH/PIGZ	8
KEGG	hsa00790	Folate biosynthesis	8/2327	26/8135	0.4766	0.8423	0.7035	GCH1/SPR/AKR1C3/MOCOS/ALPL/PTS/PCBD1/TPH1	8
KEGG	hsa04725	Cholinergic synapse	33/2327	113/8135	0.4794	0.8428	0.7039	GNB5/BCL2/CREB5/MAPK3/ADCY8/CREB3L4/CREB3L1/GNG7/ADCY1/CREB3/AKT2/KCNQ5/MAP2K1/ATF4/AKT3/GNG12/CACNA1C/GNB4/GNAQ/KCNJ2/NRAS/CAMK2A/PLCB2/HRAS/GNB1/GNAI3/PRKCB/ITPR2/ITPR1/GNB3/KRAS/GNAI2/CACNA1F	33
KEGG	hsa04974	Protein digestion and absorption	30/2327	103/8135	0.4906	0.858	0.7166	SLC7A8/COL1A1/CPB1/SLC38A2/PRSS3/ATP1A2/SLC8A1/COL5A1/PRCP/COL13A1/COL8A1/ATP1A3/COL5A2/SLC1A5/COL7A1/COL16A1/ATP1B2/COL18A1/SLC7A7/SLC15A1/COL4A4/ATP1A1/COL5A3/COL25A1/SLC7A9/COL24A1/COL6A2/SLC16A10/COL1A2/COL12A1	30
KEGG	hsa04145	Phagosome	44/2327	152/8135	0.4935	0.8585	0.717	ITGB3/ITGB1/RILP/FCGR2A/ITGAV/ATP6V1B2/ATP6V0A1/TCIRG1/ITGB5/ITGA2/SEC61B/HLA-E/THBS1/RAB5A/ATP6V1G3/TUBB2A/ATP6V1C1/HLA-G/HLA-DMA/MARCO/CD36/SEC61G/C1R/HGS/COLEC12/LAMP1/SEC61A1/ATP6V1A/EEA1/ITGA5/DYNC2H1/ATP6V0D1/CTSL/LAMP2/THBS4/MBL2/DYNC1LI2/HLA-C/ATP6V1F/DYNC1LI1/ATP6V0E2/NCF2/TFRC/ATP6V1E1	44
KEGG	hsa05016	Huntington disease	88/2327	306/8135	0.4982	0.8621	0.72	BDNF/ATG13/CREB5/DNAH6/AMBRA1/PPARG/TBPL1/CREB3L4/CREB3L1/SDHA/DNAH7/CLTCL1/SLC25A4/DNAL4/GPX3/CREB3/PIK3R4/DNALI1/CLTB/PSMB7/MAP2K7/GRIA1/ATG2B/RB1CC1/ATG2A/PSMD12/DNAH9/TUBB2A/PSMA5/PPARGC1A/VDAC2/PSMD8/PSMA4/ATG14/GNAQ/POLR2G/PSMD7/PSMB5/AP2M1/CASP9/PSMB2/GPX8/PSMB1/PSMA7/WIPI1/ULK2/IFT57/NDUFA12/KLC4/ULK1/PSMA3/PSMD6/DCTN2/AP2S1/PSMD14/KIF5C/PLCB2/NRBF2/NDUFA5/VDAC1/CREBBP/PSMD11/GPX1/NDUFC1/WIPI2/HDAC2/HIP1/ERN1/PSMC1/UQCRH/ITPR1/GRIA3/POLR2E/NDUFV3/TGM2/PSMC3/KLC1/CLTC/PSMB4/DNAH1/SP1/PSMA2/COX7A2/AP2A1/NDUFB9/SDHB/SOD2/PSMD13	88
KEGG	hsa04218	Cellular senescence	45/2327	156/8135	0.5039	0.8675	0.7245	MAPK3/IL6/FOXO1/MAPK12/TGFB3/CDK6/SLC25A4/TSC2/TGFBR2/AKT2/ZFP36L1/MAPK11/EIF4EBP1/MAP2K1/RBL2/HLA-E/MYC/TRPM7/AKT3/HLA-G/TSC1/RBBP4/MAP2K6/TRAF3IP2/VDAC2/CCNB3/RAD9A/GADD45B/NRAS/SERPINE1/IL1A/PPP3CC/GADD45G/TGFBR1/HRAS/VDAC1/HIPK2/ITPR2/CCND2/ITPR1/HLA-C/HIPK3/CCND1/KRAS/RRAS	45
KEGG	hsa04920	Adipocytokine signaling pathway	20/2327	69/8135	0.5178	0.8868	0.7407	PRKAG3/ADIPOR2/PCK2/AKT2/STK11/ACACB/SOCS3/AKT3/PPARA/CD36/PPARGC1A/TRADD/PRKAB1/SLC2A1/TNF/RXRA/ACSL6/SLC2A4/IRS2/RXRG	20
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	8/2327	27/8135	0.5256	0.8957	0.7481	TECR/ELOVL3/ELOVL6/ELOVL1/ACOT7/HSD17B12/ELOVL5/SCP2	8
KEGG	hsa05020	Prion disease	78/2327	273/8135	0.5285	0.8958	0.7482	CREB5/MAPK3/IL6/MAPK12/CREB3L4/CREB3L1/SDHA/SLC25A4/CREB3/HSPA2/NCAM2/PSMB7/HSPA1A/MAPK11/HSPA6/RYR2/PSMD12/HSPA1B/ATF4/ATF6B/TUBB2A/EIF2S1/PRNP/CACNA1C/C7/C8G/CASP12/GRIN2A/PSMA5/HSPA8/VDAC2/PSMD8/CSNK2A1/PSMA4/PSMD7/EIF2AK3/PSMB5/CASP9/PSMB2/PSMB1/PSMA7/IL1B/NDUFA12/GRIN2D/KLC4/IL1A/HSPA5/PPP3CC/PSMA3/PSMD6/BAD/PSMD14/KIF5C/LAMC1/NDUFA5/TNF/VDAC1/PSMD11/NDUFC1/ITPR2/PSMC1/UQCRH/ITPR1/NDUFV3/STIP1/PSMC3/KLC1/PSMB4/CSNK2A3/NCF2/NCAM1/PSMA2/RAC2/COX7A2/NDUFB9/SDHB/CACNA1F/PSMD13	78
KEGG	hsa00983	Drug metabolism - other enzymes	23/2327	80/8135	0.5311	0.8958	0.7482	GUSB/GSTO1/UCK2/TPMT/UCK1/CMPK1/UMPS/NME4/GSTM4/NME1/GSTP1/GSTA1/CDA/MGST1/XDH/IMPDH1/HPRT1/MGST3/GSTM2/CYP2A7/IMPDH2/DPYD/TYMP	23
KEGG	hsa03022	Basal transcription factors	13/2327	45/8135	0.5396	0.9042	0.7552	TBPL1/TAF8/MNAT1/TAF13/ERCC2/CCNH/GTF2H3/CDK7/TAF6/TAF3/TAF12/TAF2/TAF11	13
KEGG	hsa04925	Aldosterone synthesis and secretion	28/2327	98/8135	0.5415	0.9042	0.7552	CREB5/ADCY8/CREB3L4/CREB3L1/ATP1A2/CAMK1D/ADCY1/CREB3/AGTR1/ATP1A3/ATF4/ATF6B/CACNA1C/NR4A2/PRKCE/PRKD1/GNAQ/ATF1/ATP1B2/CAMK2A/PLCB2/ATP1A1/DAGLB/PRKCB/ITPR2/ITPR1/ATP2B4/CACNA1F	28
KEGG	hsa05171	Coronavirus disease - COVID-19	66/2327	232/8135	0.5467	0.9042	0.7552	C2/MAPK3/IL6/IL12A/MAPK12/FCGR2A/RPS27A/IRAK1/AGTR1/MAPK11/IRF9/RPL27/OAS1/CASP1/TRAF6/RPL24/STAT1/C7/C8G/STAT2/C1R/RPL22L1/CFD/RPL21/RPL6/RPL36/RPS12/RSL24D1/RPL26L1/C1S/IL1B/TRAF3/MX1/IL6R/RPS21/OAS2/TLR7/CFB/TNF/MYD88/PRKCB/MBL2/RPL17/IFIH1/MASP2/RPL32/ADAM17/RPS7/CCL2/TLR3/RPL22/SYK/RPS10/RPL35A/RPL11/RPS13/TLR8/VWF/FAU/RPL35/NRP1/PLCG1/RPL38/IRF3/RPL41/RPL23A	66
KEGG	hsa04710	Circadian rhythm	9/2327	31/8135	0.5469	0.9042	0.7552	PRKAG3/NPAS2/CRY2/PER1/PER3/PRKAB1/CLOCK/NR1D1/ARNTL	9
KEGG	hsa03250	Viral life cycle - HIV-1	18/2327	63/8135	0.5502	0.9053	0.756	MAP1B/VPS4B/BST2/FURIN/BICD1/CDK9/APOBEC3D/CHMP4B/HGS/RAN/MX1/MLLT3/CREBBP/APOBEC3C/MAP1A/ELL2/CXCR4/ELL	18
KEGG	hsa05146	Amoebiasis	29/2327	102/8135	0.5533	0.9059	0.7566	COL1A1/LAMA2/ACTN1/IL6/IL12A/TGFB3/IL1R1/ADCY1/LAMB1/IL1R2/RAB5A/C8G/LAMA4/LAMA3/VCL/GNAQ/PTK2/LAMA1/IL1B/GNAL/CXCL2/PLCB2/LAMC1/TNF/COL4A4/PRKCB/LAMB4/FN1/COL1A2	29
KEGG	hsa04270	Vascular smooth muscle contraction	38/2327	134/8135	0.5584	0.9066	0.7571	RAMP2/MAPK3/ADM2/ADCY8/PTGIR/MYL6B/ADCY1/AGTR1/MAP2K1/CACNA1C/EDN1/CALCRL/PRKCE/PLA2G4A/GNAQ/CALD1/ADORA2A/KCNMA1/ROCK1/PLCB2/PLA2G2A/PLA2G6/ADRA1D/PRKCB/BRAF/RHOA/ITPR2/EDNRA/MYLK3/ITPR1/MYL6/NPR2/GNA12/PLA2G4C/CALCA/RAMP1/ARHGEF11/CACNA1F	38
KEGG	hsa00120	Primary bile acid biosynthesis	5/2327	17/8135	0.5618	0.9066	0.7571	HSD3B7/CYP27A1/ACOT8/CYP39A1/SCP2	5
KEGG	hsa00910	Nitrogen metabolism	5/2327	17/8135	0.5618	0.9066	0.7571	GLUD2/CA13/CA2/CA12/GLUL	5
KEGG	hsa04612	Antigen processing and presentation	22/2327	78/8135	0.5742	0.922	0.7701	TAPBP/HSP90AB1/HSPA2/HSPA1A/KLRD1/HSPA6/HLA-E/HSPA1B/HLA-G/HLA-DMA/HSPA8/PSME3/LGMN/HSPA5/CTSL/TNF/PSME2/B2M/RFXAP/HLA-C/NFYC/HSP90AA1	22
KEGG	hsa04310	Wnt signaling pathway	47/2327	167/8135	0.5825	0.9309	0.7775	RSPO2/RSPO3/FZD6/ROR1/TLE1/FRZB/WNT9B/LEF1/LRP5/FZD1/ROR2/DKK1/DAAM1/PORCN/MYC/DVL2/PRICKLE2/FZD10/CSNK2A1/LGR4/LRP6/PPP3CC/FRAT1/CAMK2A/RYK/TLE4/PLCB2/CSNK1A1/CREBBP/ZNRF3/PRKCB/PPARD/INVS/RHOA/LGR5/WNT9A/CCND2/WNT5B/CTNNBIP1/RUVBL1/CSNK2A3/FZD8/APC2/CCND1/RAC2/CACYBP/CSNK1A1L	47
KEGG	hsa01240	Biosynthesis of cofactors	43/2327	153/8135	0.5857	0.9315	0.7779	AK7/GUSB/KYNU/GCLM/MTHFD2/PSAT1/AK5/GCH1/NADK2/SHMT2/BCAT1/SPR/AK9/ALAD/MTHFD2L/HSD17B6/ADSL/ALDH3A2/AK2/CTPS1/MTHFD1L/CMPK1/UMPS/NME4/ALDH1B1/NMNAT2/NME1/AK8/VKORC1/COX10/PMM2/NMNAT3/CMPK2/ALPL/GCLC/CTPS2/AK4/PTS/AK1/PHOSPHO2/COQ5/OXSM/RDH13	43
KEGG	hsa03320	PPAR signaling pathway	21/2327	75/8135	0.59	0.9315	0.7779	SORBS1/PPARG/CPT2/PCK2/CYP27A1/PLTP/NR1H3/PLIN2/PPARA/GK/CD36/ME3/APOA1/AQP7/APOA5/PPARD/SCP2/RXRA/ACSL6/RXRG/ACADM	21
KEGG	hsa05164	Influenza A	48/2327	171/8135	0.5912	0.9315	0.7779	MAPK3/IL6/IL12A/PRSS3/CDK6/RAB11B/SLC25A4/AKT2/SOCS3/IRF7/NXT1/MAP2K1/IRF9/RSAD2/OAS1/CASP1/AKT3/STAT1/NXF1/EIF2S1/HLA-DMA/STAT2/BAK1/KPNA1/TRADD/CASP9/BID/IL1B/FAS/TRAF3/MX1/IL1A/OAS2/TLR7/TNF/VDAC1/MYD88/CREBBP/TMPRSS11D/PRKCB/IFIH1/RAB11A/CCL2/TNFRSF10B/TLR3/KPNA6/IL18/IRF3	48
KEGG	hsa04024	cAMP signaling pathway	62/2327	221/8135	0.5985	0.9349	0.7808	BDNF/VAV3/CREB5/MAPK3/ADCY8/PLD1/GLI3/CREB3L4/ATP2A3/CREB3L1/ABCC4/ATP1A2/PDE4D/HCN2/SSTR1/ADCY1/CREB3/AKT2/SOX9/PDE4B/GRIA1/MAP2K1/F2R/HHIP/RYR2/ATP1A3/AKT3/PPARA/CACNA1C/EDN1/VIP/RAP1B/GRIN2A/PTCH1/GABBR2/ADORA2A/DRD2/ATP1B2/GRIN2D/PDE3A/ROCK1/CAMK2A/BAD/PLD2/CFTR/CREBBP/ATP1A1/GNAI3/BRAF/RHOA/PDE4A/EDNRA/GRIA3/CGA/OXTR/GNAI2/RAPGEF3/RAC2/ATP2B4/RRAS/HCAR1/CACNA1F	62
KEGG	hsa00590	Arachidonic acid metabolism	17/2327	61/8135	0.599	0.9349	0.7808	PTGS2/TBXAS1/GPX3/CBR3/PTGES/AKR1C3/EPHX2/CYP2C8/PLA2G4A/GPX8/PTGDS/PLA2G2A/PTGIS/PLA2G6/GPX1/PLA2G4C/LTC4S	17
KEGG	hsa00350	Tyrosine metabolism	10/2327	36/8135	0.6063	0.9376	0.783	TYR/DCT/GOT1/FAH/GSTZ1/LRTOMT/ADH7/GOT2/AOX1/ALDH3B1	10
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	10/2327	36/8135	0.6063	0.9376	0.783	BST1/SIRT3/NADK2/NMNAT2/NMRK1/PNP/SIRT2/NMNAT3/AOX1/SIRT4	10
KEGG	hsa05014	Amyotrophic lateral sclerosis	102/2327	364/8135	0.6194	0.9509	0.7941	ATG13/RAB39B/BCL2/DNAH6/AMBRA1/MAPK12/PFN2/SDHA/DNAH7/DNAL4/XBP1/GPX3/SEH1L/PIK3R4/SPG11/DNALI1/PSMB7/MAPK11/NXT1/GRIA1/ATG2B/SEC13/RB1CC1/ATG2A/RAB5A/PSMD12/ATF6/ATF4/CASP1/DNAH9/TUBB2A/CCS/NXF1/EIF2S1/ERBB4/CASP12/GRIN2A/PSMA5/UBQLN1/MAP2K6/WDR41/PSMD8/PSMA4/ATG14/HNRNPA1L2/PSMD7/EIF2AK3/PSMB5/CASP9/PSMB2/GPX8/PSMB1/MAP1LC3A/PSMA7/BID/PFN1/WIPI1/ULK2/NDUFA12/GRIN2D/KLC4/HSPA5/PPP3CC/ULK1/PSMA3/PSMD6/BAD/DCTN2/PSMD14/KIF5C/SMCR8/ANG/NRBF2/NDUFA5/TNF/VDAC1/PSMD11/GPX1/NDUFC1/WIPI2/ALS2/TARDBP/ERN1/PSMC1/UQCRH/HDAC6/HNRNPA3/NDUFV3/BCL2L1/PSMC3/KLC1/PSMB4/DNAH1/MAP1LC3C/NCBP1/PSMA2/COX7A2/NDUFB9/SDHB/PSMD13/NRG1/ATXN2L	102
KEGG	hsa00260	Glycine, serine and threonine metabolism	11/2327	40/8135	0.6206	0.9509	0.7941	CTH/PSAT1/CBS/SHMT2/PSPH/GCAT/GRHPR/CHDH/BPGM/PHGDH/SDS	11
KEGG	hsa04934	Cushing syndrome	43/2327	155/8135	0.625	0.9531	0.796	CREB5/MAPK3/ADCY8/FZD6/CREB3L4/AIP/CREB3L1/WNT9B/CDK6/LEF1/ADCY1/CREB3/AGTR1/FZD1/MAP2K1/ATF4/DVL2/FH/ATF6B/CACNA1C/KCNK2/RAP1B/FZD10/NCEH1/ARNT/GNAQ/CYP17A1/RASD1/CAMK2A/PLCB2/GNAI3/BRAF/ITPR2/WNT9A/ITPR1/WNT5B/FZD8/APC2/CCND1/MEN1/SP1/GNAI2/CACNA1F	43
KEGG	hsa03410	Base excision repair	9/2327	33/8135	0.6321	0.9543	0.797	TDG/PARP4/NEIL1/MUTYH/POLD2/NEIL2/PARP3/LIG3/POLL	9
KEGG	hsa04130	SNARE interactions in vesicular transport	9/2327	33/8135	0.6321	0.9543	0.797	STX4/VTI1B/VAMP5/STX6/STX11/GOSR2/SNAP29/VAMP4/STX3	9
KEGG	hsa00340	Histidine metabolism	6/2327	22/8135	0.6343	0.9543	0.797	HNMT/ALDH3A2/ALDH1B1/ASPA/FTCD/ALDH3B1	6
KEGG	hsa05140	Leishmaniasis	21/2327	77/8135	0.6446	0.9618	0.8033	MAPK3/IL12A/PTGS2/MAPK12/ITGB1/FCGR2A/TGFB3/IRAK1/MARCKSL1/TAB1/MAPK11/TRAF6/STAT1/ITGA4/HLA-DMA/IL1B/IL1A/TNF/MYD88/PRKCB/NCF2	21
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	10/2327	37/8135	0.6451	0.9618	0.8033	MAPK3/ATP1A2/ATP1A3/NEDD4L/INSR/ATP1B2/SCNN1A/ATP1A1/PRKCB/KRAS	10
KEGG	hsa04540	Gap junction	24/2327	88/8135	0.6488	0.9623	0.8037	TJP1/MAPK3/ADCY8/PDGFC/LPAR1/ADCY1/EGF/MAP2K1/TUBB2A/MAP2K5/PDGFRB/GNAQ/SOS1/NRAS/DRD2/PLCB2/HRAS/GNAI3/PRKCB/ITPR2/ITPR1/PDGFD/KRAS/GNAI2	24
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/2327	70/8135	0.6511	0.9623	0.8037	TJP1/MAPK12/ATP6V1B2/ATP6V0A1/TCIRG1/LYN/MAPK11/ATP6V1G3/ATP6V1C1/ATP6V1A/MET/CDC42/CXCL2/ATP6V0D1/ADAM17/ATP6V1F/ATP6V0E2/PLCG1/ATP6V1E1	19
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2327	15/8135	0.6611	0.9727	0.8124	A4GALT/HEXA/HEXB/FUT1	4
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	5/2327	19/8135	0.6714	0.9736	0.8132	GPT2/BCAT1/GOT1/IDH3A/GOT2	5
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	61/2327	222/8135	0.6714	0.9736	0.8132	CREB5/MAPK3/IL6/ADCY8/TBPL1/CREB3L4/CREB3L1/TGFB3/STAT5A/SLC25A4/IL1R1/ADCY1/CREB3/TGFBR2/AKT2/CD40/IL1R2/VAC14/ZFP36/MAP2K1/HLA-E/MAP3K1/MYC/ATF4/ATF6B/AKT3/LTBR/TLN2/HLA-G/HLA-DMA/EGR2/MSX2/CRTC2/VDAC2/RAN/ANAPC10/DLG1/NRAS/SLC2A1/IL15RA/PPP3CC/TGFBR1/HRAS/TNF/VDAC1/CREBBP/CRTC3/RANBP3/CRTC1/STAT5B/B2M/MAP3K3/CCND2/ANAPC1/HLA-C/BCL2L1/RELB/NRP1/CCND1/KRAS/TLN1	61
KEGG	hsa04727	GABAergic synapse	24/2327	89/8135	0.6731	0.9736	0.8132	GNB5/SLC38A1/SLC38A2/ADCY8/GNG7/TRAK2/ADCY1/SLC6A12/GNG12/CACNA1C/GABARAPL1/GNB4/SLC38A5/GABBR2/ABAT/GABRA4/GNB1/GNAI3/PRKCB/GABARAP/GLUL/GNB3/GNAI2/CACNA1F	24
KEGG	hsa04921	Oxytocin signaling pathway	42/2327	154/8135	0.6734	0.9736	0.8132	PRKAG3/MAPK3/ADCY8/PTGS2/CACNA2D3/CAMK1D/MYL6B/ADCY1/CACNA2D4/MAP2K1/CACNA2D1/RYR2/MEF2C/MAP2K5/CACNA1C/PLA2G4A/GNAQ/KCNJ2/EEF2K/NRAS/PRKAB1/ROCK1/PPP3CC/CAMK2A/PLCB2/HRAS/RGS2/GNAI3/PRKCB/RHOA/ITPR2/MYLK3/ITPR1/MYL6/NPR2/OXTR/CCND1/PLA2G4C/KRAS/GNAI2/CACNA1F/CACNB1	42
KEGG	hsa03040	Spliceosome	40/2327	147/8135	0.677	0.9746	0.814	SLU7/HSPA2/HSPA1A/HSPA6/HSPA1B/XAB2/SNRPD3/SNRPF/HSPA8/HNRNPA1L2/BCAS2/PLRG1/SNRPB2/CRNKL1/TXNL4A/ACIN1/PRPF40B/SF3B1/THOC3/SNRPD1/RBM25/SRSF9/NCBP2L/SNRPE/SF3A3/PHF5A/SNRPD2/MAGOH/SYF2/SRSF1/HNRNPA3/TRA2B/SNRPC/RNU6-1/NCBP1/RNU4-1/CHERP/SF3B4/SNRPA1/BUD31	40
KEGG	hsa05170	Human immunodeficiency virus 1 infection	58/2327	212/8135	0.6829	0.9789	0.8175	GNB5/BCL2/MAPK3/BST2/MAPK12/GNG7/TAPBP/IRAK1/AKT2/WEE1/MAP2K7/TAB1/MAPK11/MAP2K1/HLA-E/APOBEC3D/TRAF6/AKT3/GNG12/CUL4A/HLA-G/GNB4/MAP2K6/GNAQ/BAK1/TRADD/CCNB3/CASP9/PTK2/BID/FAS/NRAS/PPP3CC/BAD/HRAS/TNF/MYD88/RNF7/GNB1/GNAI3/PRKCB/APOBEC3C/ITPR2/B2M/ITPR1/CUL5/HLA-C/BCL2L1/TRAF5/PAK2/PLCG1/GNB3/KRAS/GNAI2/RAC2/CXCR4/IRF3/AP1M1	58
KEGG	hsa00380	Tryptophan metabolism	11/2327	42/8135	0.6912	0.9824	0.8205	KYNU/DHTKD1/CYP1B1/ALDH3A2/HADHA/INMT/ALDH1B1/ACAT1/AOX1/AANAT/TPH1	11
KEGG	hsa05332	Graft-versus-host disease	11/2327	42/8135	0.6912	0.9824	0.8205	IL6/KLRD1/HLA-E/HLA-G/HLA-DMA/IL1B/FAS/IL1A/TNF/HLA-C/CD80	11
KEGG	hsa03018	RNA degradation	21/2327	79/8135	0.6955	0.9827	0.8207	HSPA9/HSPD1/DCP1B/EXOSC6/TOB1/PABPC5/XRN2/PABPC1L/CNOT4/ZCCHC7/PAN2/WDR61/XRN1/ENO4/MPHOSPH6/CNOT8/CNOT6L/ENO2/EXOSC1/ENO1/LSM1	21
KEGG	hsa00052	Galactose metabolism	8/2327	31/8135	0.6995	0.9827	0.8207	GALM/B4GALT2/GAA/HKDC1/PGM1/GALT/GLB1/PGM2	8
KEGG	hsa04930	Type II diabetes mellitus	12/2327	46/8135	0.7003	0.9827	0.8207	MAPK3/PRKCZ/SOCS3/KCNJ11/CACNA1C/PRKCE/HKDC1/INSR/TNF/CACNA1E/SLC2A4/IRS2	12
KEGG	hsa04062	Chemokine signaling pathway	52/2327	192/8135	0.7071	0.9882	0.8253	GNB5/CCR1/ARRB1/VAV3/MAPK3/ADCY8/CCR3/HCK/GNG7/PRKCZ/ADCY1/AKT2/LYN/MAP2K1/SHC1/AKT3/STAT1/GNG12/DOCK2/XCR1/RAP1B/GNB4/STAT2/GNAQ/SOS1/PTK2/ARRB2/NRAS/CDC42/CXCL2/ROCK1/BAD/PLCB2/HRAS/GNB1/GNAI3/PRKCB/BRAF/SHC2/CCL20/STAT5B/RHOA/CCL26/CCL2/CCR7/PLCG1/GNB3/ELMO1/KRAS/GNAI2/RAC2/CXCR4	52
KEGG	hsa04971	Gastric acid secretion	20/2327	76/8135	0.7118	0.9905	0.8273	ADCY8/ATP1A2/KCNJ15/ADCY1/ATP1A3/KCNK2/GNAQ/KCNJ2/ATP1B2/CA2/CAMK2A/PLCB2/CFTR/ATP1A1/GNAI3/PRKCB/ITPR2/MYLK3/ITPR1/GNAI2	20
KEGG	hsa05142	Chagas disease	27/2327	102/8135	0.719	0.9964	0.8322	MAPK3/IL6/IL12A/MAPK12/TGFB3/ADCY1/IRAK1/TGFBR2/AKT2/MAPK11/TRAF6/AKT3/GNAQ/IL1B/GNAL/FAS/SERPINE1/PPP2R2C/TGFBR1/PLCB2/PPP2R1A/TNF/MYD88/BDKRB2/GNAI3/CCL2/GNAI2	27
KEGG	hsa05203	Viral carcinogenesis	55/2327	204/8135	0.725	1	0.8352	ACTN1/CREB5/MAPK3/CCR3/GSN/TBPL1/CREB3L4/CREB3L1/HDAC4/CDK6/STAT5A/CREB3/YWHAB/IRF7/VAC14/LYN/DNAJA3/HPN/RBL2/HLA-E/IRF9/ATF4/ATF6B/LTBR/HLA-G/EGR2/CHD4/HDAC5/BAK1/TRADD/GTF2H3/DLG1/TRAF3/NRAS/USP7/CDC42/BAD/ATP6V0D1/HRAS/CREBBP/SP100/YWHAZ/STAT5B/RHOA/UBR4/HDAC2/PSMC1/CCND2/HDAC6/SYK/HLA-C/TRAF5/CCND1/KRAS/IRF3	55
KEGG	hsa04973	Carbohydrate digestion and absorption	12/2327	47/8135	0.7306	1	0.8352	ATP1A2/SLC37A4/AKT2/SLC2A5/ATP1A3/AKT3/HKDC1/ATP1B2/AMY2B/PLCB2/ATP1A1/PRKCB	12
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	38/2327	143/8135	0.7349	1	0.8352	MAPK3/FZD6/FGF2/MAPK12/ACVR2B/WNT9B/AKT2/PCGF1/PCGF5/FZD1/INHBE/ACVR1/MAPK11/ID3/MAP2K1/MYC/DVL2/AKT3/ID4/FZD10/NRAS/IGF1R/LIF/HRAS/FGFR4/INHBA/ESRRB/WNT9A/NODAL/INHBB/WNT5B/FGFR2/FZD8/APC2/POU5F1B/SMAD9/KRAS/SMAD1	38
KEGG	hsa04913	Ovarian steroidogenesis	13/2327	51/8135	0.7375	1	0.8352	ADCY8/PTGS2/ADCY1/HSD17B7/CYP1B1/AKR1C3/BMP6/PLA2G4A/CYP17A1/INSR/IGF1R/CGA/PLA2G4C	13
KEGG	hsa04726	Serotonergic synapse	30/2327	115/8135	0.7575	1	0.8352	GNB5/MAPK3/PTGS2/GNG7/MAP2K1/GNG12/CACNA1C/GNB4/CYP2C8/PLA2G4A/GNAQ/NRAS/SLC18A2/KCND2/PLCB2/HRAS/GNB1/GNAI3/PRKCB/BRAF/HTR3E/ITPR2/ITPR1/TPH1/GNB3/PLA2G4C/KRAS/GNAI2/RAPGEF3/CACNA1F	30
KEGG	hsa04625	C-type lectin receptor signaling pathway	27/2327	104/8135	0.7586	1	0.8352	MAPK3/IL6/IL12A/PTGS2/MAPK12/AKT2/MAPK11/IRF9/CASP1/AKT3/STAT1/EGR2/STAT2/IL23A/LSP1/IL1B/NRAS/PPP3CC/HRAS/TNF/RHOA/ITPR2/ITPR1/SYK/RELB/KRAS/RRAS	27
KEGG	hsa00770	Pantothenate and CoA biosynthesis	5/2327	21/8135	0.7612	1	0.8352	BCAT1/ALDH3A2/ALDH1B1/CSAD/DPYD	5
KEGG	hsa03450	Non-homologous end-joining	3/2327	13/8135	0.7657	1	0.8352	POLM/XRCC6/POLL	3
KEGG	hsa04713	Circadian entrainment	25/2327	97/8135	0.7662	1	0.8352	GNB5/MAPK3/ADCY8/GNG7/ADCY1/GRIA1/RYR2/GNG12/CACNA1C/GNB4/GRIN2A/PER1/GNAQ/PER3/RASD1/GRIN2D/CAMK2A/PLCB2/GNB1/GNAI3/PRKCB/ITPR1/GRIA3/GNB3/GNAI2	25
KEGG	hsa04911	Insulin secretion	22/2327	86/8135	0.7691	1	0.8352	CREB5/ADCY8/CREB3L4/CREB3L1/ATP1A2/ADCY1/CREB3/RYR2/ATP1A3/ATF4/ATF6B/KCNJ11/CACNA1C/GNAQ/ATP1B2/KCNMA1/SLC2A1/CAMK2A/PLCB2/ATP1A1/PRKCB/CACNA1F	22
KEGG	hsa04978	Mineral absorption	15/2327	60/8135	0.7748	1	0.8352	SLC31A1/ATP1A2/SLC8A1/ATP1A3/TRPM7/STEAP2/CYBRD1/ATP1B2/SLC40A1/MT1G/SLC11A2/HMOX2/ATP1A1/FTH1/ATP2B4	15
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	25/2327	98/8135	0.7848	1	0.8352	PTGER4/ADCY8/NGF/MAPK12/IL1R1/ADCY1/MAPK11/ASIC3/IL1RAP/PRKCE/MAP2K6/PLA2G4A/GNAQ/F2RL1/IL1B/CAMK2A/PLCB2/BDKRB2/PLA2G6/PRKCB/TRPV1/ITPR2/ITPR1/PLCG1/PLA2G4C	25
KEGG	hsa04260	Cardiac muscle contraction	22/2327	87/8135	0.7886	1	0.8352	ATP2A3/CACNA2D3/ATP1A2/SLC9A7/SLC8A1/CACNA2D4/CACNA2D1/RYR2/ATP1A3/CACNA1C/TPM1/SLC9A6/ATP1B2/TNNC1/ATP1A1/TPM2/CASQ2/UQCRH/COX7A2/MYL3/CACNA1F/CACNB1	22
KEGG	hsa05032	Morphine addiction	23/2327	91/8135	0.7934	1	0.8352	GNB5/ARRB1/PDE7A/ADCY8/PDE1C/GNG7/PDE4D/PDE1A/ADCY1/PDE4B/GNG12/GNB4/GABBR2/ARRB2/PDE3A/GABRA4/GNB1/GNAI3/PRKCB/PDE4A/GNB3/PDE1B/GNAI2	23
KEGG	hsa05152	Tuberculosis	47/2327	180/8135	0.7963	1	0.8352	BCL2/MAPK3/IL6/IL12A/MAPK12/FCGR2A/HSPA9/TGFB3/ATP6V0A1/TCIRG1/IRAK1/CEBPB/HSPD1/AKT2/CEBPG/MAPK11/RAB5A/TRAF6/AKT3/STAT1/TLR1/HLA-DMA/LBP/IL23A/TRADD/CASP9/LAMP1/LSP1/BID/IL1B/EEA1/IL1A/PPP3CC/CAMK2A/BAD/RIPK2/ATP6V0D1/CYP27B1/TNF/MYD88/CREBBP/LAMP2/RHOA/SYK/RFXAP/IL18/NFYC	47
KEGG	hsa00030	Pentose phosphate pathway	7/2327	30/8135	0.7977	1	0.8352	TALDO1/RPE/PGM1/FBP1/H6PD/ALDOC/PGM2	7
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	7/2327	30/8135	0.7977	1	0.8352	ACSS1/SHMT2/ACAT1/GRHPR/HOGA1/PCCA/GLUL	7
KEGG	hsa00220	Arginine biosynthesis	5/2327	22/8135	0.7985	1	0.8352	GPT2/GLUD2/GOT1/GOT2/GLUL	5
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/2327	22/8135	0.7985	1	0.8352	ACAT1/FNTB/DHDDS/PCYOX1/PDSS1	5
KEGG	hsa05330	Allograft rejection	9/2327	38/8135	0.801	1	0.8352	IL12A/CD40/HLA-E/HLA-G/HLA-DMA/FAS/TNF/HLA-C/CD80	9
KEGG	hsa04630	JAK-STAT signaling pathway	42/2327	162/8135	0.8014	1	0.8352	BCL2/IL6/IL12A/IL27RA/STAM/IL22RA1/PIM1/STAT5A/IL7/AKT2/FHL1/EGF/SOCS3/SOCS5/IRF9/MYC/AKT3/STAT1/IL20RB/STAT6/PDGFRB/STAT2/IL23A/SOS1/IL11RA/IL11/IL15RA/IL6R/LIF/HRAS/CREBBP/STAT4/CSF2RB/STAT5B/AOX1/CCND2/PRL/IL20RA/BCL2L1/IL12RB1/CCND1/THPO	42
KEGG	hsa05321	Inflammatory bowel disease	16/2327	65/8135	0.8015	1	0.8352	IL6/IL12A/TGFB3/TLR5/MAF/STAT1/STAT6/HLA-DMA/IL23A/IL1B/IL1A/TNF/STAT4/IL18R1/IL12RB1/IL18	16
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	17/2327	69/8135	0.8054	1	0.8352	GSTO1/PTGS2/AKR1C2/HSD11B1L/CYP1B1/CYP3A43/SULT1A1/CYP2C8/EPHX1/GSTM4/GSTK1/GSTP1/GSTA1/MGST1/MGST3/GSTM2/CYP2A7	17
KEGG	hsa04932	Non-alcoholic fatty liver disease	40/2327	155/8135	0.8065	1	0.8352	PRKAG3/ADIPOR2/IL6/PPARG/MAPK12/BCL2L11/SDHA/XBP1/AKT2/SOCS3/MAPK11/NR1H3/ATF4/AKT3/EIF2S1/PPARA/MLXIP/EIF2AK3/INSR/BID/IL1B/FAS/NDUFA12/PRKAB1/CDC42/IL6R/IL1A/NDUFA5/TNF/SREBF1/NDUFC1/RXRA/ERN1/UQCRH/NDUFV3/ITCH/COX7A2/NDUFB9/SDHB/IRS2	40
KEGG	hsa05012	Parkinson disease	70/2327	266/8135	0.8179	1	0.8352	UBE2J1/SDHA/RPS27A/SLC25A4/XBP1/PSMB7/SLC39A1/PSMD12/ATF6/ATF4/TUBB2A/KEAP1/EIF2S1/PSMA5/VDAC2/PSMD8/SLC39A2/PSMA4/UBE2G2/PSMD7/EIF2AK3/PSMB5/CASP9/SLC39A7/PSMB2/PSMB1/PSMA7/UCHL1/GNAL/NDUFA12/ADORA2A/DRD2/SLC18A2/PARK7/MAPT/KLC4/HSPA5/PSMA3/PSMD6/CAMK2A/PSMD14/KIF5C/NDUFA5/VDAC1/SLC11A2/PSMD11/GNAI3/NDUFC1/UBA7/ITPR2/ERN1/PSMC1/UQCRH/ITPR1/NDUFV3/BCL2L1/PSMC3/KLC1/PSMB4/SLC39A8/PLCG1/PSMA2/GNAI2/UBE2L3/COX7A2/LRRK2/TXN/NDUFB9/SDHB/PSMD13	70
KEGG	hsa03013	Nucleocytoplasmic transport	27/2327	108/8135	0.8264	1	0.8352	XPOT/TNPO1/SEH1L/XPO5/NXT1/SEC13/RANBP17/THOC7/NXF1/KPNA3/IPO5/XPO6/KPNA1/RAN/SUMO1/ACIN1/KPNB1/THOC3/THOC6/KPNA4/NCBP2L/PNN/IPO7/MAGOH/UPF3A/KPNA6/NCBP1	27
KEGG	hsa04659	Th17 cell differentiation	27/2327	108/8135	0.8264	1	0.8352	MAPK3/IL6/IL27RA/MAPK12/STAT5A/HSP90AB1/IL1R1/TGFBR2/MAPK11/IL1RAP/STAT1/STAT6/HLA-DMA/IL23A/IL1B/IL6R/PPP3CC/RUNX1/TGFBR1/IRF4/STAT5B/RXRA/RARA/IL12RB1/PLCG1/RXRG/HSP90AA1	27
KEGG	hsa03420	Nucleotide excision repair	11/2327	47/8135	0.8293	1	0.8352	ERCC6/MNAT1/ERCC2/CUL4A/CCNH/GTF2H3/CDK7/RAD23B/POLD2/ERCC1/RPA4	11
KEGG	hsa04614	Renin-angiotensin system	5/2327	23/8135	0.8311	1	0.8352	CTSA/PRCP/AGTR1/LNPEP/NLN	5
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	19/2327	78/8135	0.8311	1	0.8352	AKR1C1/GSTO1/AKR7A2/HSD11B1L/DHDH/AKR7A3/CBR3/CYP1B1/EPHX1/GSTM4/GSTK1/GSTP1/GSTA1/MGST1/ADH7/MGST3/GSTM2/CYP2A7/ALDH3B1	19
KEGG	hsa04662	B cell receptor signaling pathway	20/2327	82/8135	0.8342	1	0.8352	VAV3/MAPK3/IFITM1/AKT2/CD72/LYN/MAP2K1/AKT3/SOS1/RASGRP3/NRAS/PPP3CC/HRAS/PRKCB/CD81/SYK/CD19/KRAS/RAC2/INPP5D	20
KEGG	hsa04623	Cytosolic DNA-sensing pathway	15/2327	63/8135	0.8378	1	0.8352	IL6/POLR3D/POLR3G/POLR3B/IRF7/CASP1/POLR3K/POLR3F/POLR3H/IL1B/POLR3E/POLR1C/POLR2E/IL18/IRF3	15
KEGG	hsa04657	IL-17 signaling pathway	23/2327	94/8135	0.8433	1	0.8352	MAPK3/IL6/PTGS2/MAPK12/HSP90AB1/TNFAIP3/CEBPB/MAPK11/TRAF6/TRAF3IP2/TRAF4/USP25/TRADD/IL1B/TRAF3/CXCL2/TNF/CCL20/IL17B/CCL2/SRSF1/TRAF5/HSP90AA1	23
KEGG	hsa04923	Regulation of lipolysis in adipocytes	13/2327	56/8135	0.8524	1	0.8352	ADCY8/PTGS2/ADCY1/AKT2/ABHD5/PNPLA2/AKT3/INSR/AQP7/GNAI3/CGA/GNAI2/IRS2	13
KEGG	hsa04217	Necroptosis	40/2327	159/8135	0.8559	1	0.8352	VPS4B/BCL2/STAT5A/HSP90AB1/SLC25A4/TNFAIP3/GLUD2/CHMP1B/BIRC3/IRF9/TRPM7/CASP1/STAT1/STAT6/AIFM1/CHMP4B/STAT2/PLA2G4A/VDAC2/TRADD/BID/DNM1L/IL1B/FAS/IL1A/CAMK2A/USP21/TNF/VDAC1/STAT4/FTH1/BIRC2/GLUL/STAT5B/TNFRSF10B/TLR3/TRAF5/CHMP7/PLA2G4C/HSP90AA1	40
KEGG	hsa00982	Drug metabolism - cytochrome P450	17/2327	72/8135	0.8591	1	0.8352	FMO5/GSTO1/FMO4/CYP2C8/FMO3/GSTM4/GSTK1/GSTP1/GSTA1/MGST1/ADH7/AOX1/MGST3/GSTM2/FMO2/CYP2A7/ALDH3B1	17
KEGG	hsa04640	Hematopoietic cell lineage	24/2327	99/8135	0.8602	1	0.8352	IL6/ITGB3/IL7/IL1R1/IL1R2/ITGA2/CSF1/ITGA4/HLA-DMA/CD36/KITLG/IL1B/IL11RA/IL11/ITGA5/IL6R/IL1A/CD37/ITGA6/TNF/CD34/CD19/THPO/TFRC	24
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2327	11/8135	0.8673	1	0.8352	VKORC1/COQ5	2
KEGG	hsa05150	Staphylococcus aureus infection	23/2327	96/8135	0.8712	1	0.8352	CFI/C2/KRT33B/KRT34/FCGR2A/KRT19/KRT23/HLA-DMA/C1R/CFD/DEFB1/KRT18/C1S/FPR3/KRT16/CFB/KRT15/MBL2/MASP2/KRT38/KRT14/KRT27/KRT24	23
KEGG	hsa05031	Amphetamine addiction	16/2327	69/8135	0.8729	1	0.8352	CREB5/CREB3L4/CREB3L1/CREB3/GRIA1/ATF4/ATF6B/CACNA1C/GRIN2A/SLC18A2/GRIN2D/PPP3CC/CAMK2A/PRKCB/HDAC2/GRIA3	16
KEGG	hsa00360	Phenylalanine metabolism	3/2327	16/8135	0.8787	1	0.8352	GOT1/GOT2/ALDH3B1	3
KEGG	hsa03015	mRNA surveillance pathway	23/2327	97/8135	0.8837	1	0.8352	MSI2/PELO/NXT1/ETF1/SSU72/PABPC5/PABPC1L/NXF1/PPP2R3A/CSTF3/PAPOLG/ACIN1/PPP2R2C/FIP1L1/PPP2R1A/NCBP2L/PNN/MAGOH/UPF3A/TARDBP/PPP2R5D/NCBP1/SMG1	23
KEGG	hsa05168	Herpes simplex virus 1 infection	130/2327	495/8135	0.8934	1	0.8352	BCL2/IL6/IL12A/BST2/ITGB3/ZFP14/ZNF429/ZNF214/TAPBP/ZNF19/ZNF688/TSC2/ZNF223/IRAK1/AKT2/ZNF605/SOCS3/ZNF585A/IRF7/ZNF460/ZNF425/ZNF211/ZNF773/TAB1/EIF4EBP1/BIRC3/POU2F1/HLA-E/IRF9/ZNF84/ZNF98/OAS1/ZNF836/ZNF419/ZNF620/TRAF6/AKT3/STAT1/NXF1/EIF2S1/ZNF3/ZNF253/HLA-G/HLA-DMA/ZNF182/TSC1/ZNF713/ZNF506/ZNF354C/STAT2/TNFRSF14/ZNF546/ZNF891/ZNF350/ZNF33B/ZNF727/BAK1/EIF2AK3/ZFP69B/TRADD/CASP9/ZNF540/ZNF585B/BID/ZNF785/ZNF558/IL1B/SRPK1/FAS/ZNF212/ZNF845/ZNF331/ZNF606/ITGA5/ZNF619/TRAF3/ZNF737/ZNF141/ZNF436/EIF2B3/ZNF577/ZNF160/ZNF300/ZNF615/ZNF354B/OAS2/ZNF600/BAD/ZNF841/SRSF9/TNF/MYD88/ZNF25/SP100/BIRC2/ZNF596/IFIH1/EIF2AK4/ZNF99/ZNF227/ZNF254/ZNF599/B2M/ZNF415/CCL2/TLR3/SRSF1/POU2F3/SYK/HLA-C/BCL2L1/ZNF555/EIF2B2/ZNF267/ZNF234/ZNF846/ZNF624/TRAF5/ZNF275/ZNF83/ZNF316/ZNF778/ZNF548/ZNF10/ZNF132/IRF3/ZNF510/ZNF860/ZNF343/ZNF517	130
KEGG	hsa00071	Fatty acid degradation	9/2327	43/8135	0.9042	1	0.8352	ACADS/CPT2/ALDH3A2/HADHA/ALDH1B1/ACAT1/ADH7/ACSL6/ACADM	9
KEGG	hsa04975	Fat digestion and absorption	9/2327	43/8135	0.9042	1	0.8352	ABCA1/CD36/DGAT1/ACAT1/APOB/APOA1/CEL/PLA2G2A/GOT2	9
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	31/2327	131/8135	0.915	1	0.8352	VAV3/MAPK3/RAET1G/ULBP2/ULBP1/KLRD1/MAP2K1/HLA-E/SHC1/HLA-G/RAET1E/SOS1/BID/FAS/NRAS/PPP3CC/HRAS/TNF/ICAM2/PRKCB/BRAF/SHC2/KLRK1/TNFRSF10B/SYK/HLA-C/ULBP3/PLCG1/KRAS/RAC2/SH3BP2	31
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/2327	100/8135	0.9154	1	0.8352	CCR1/IL6/CCR3/IL22RA1/CSF1/ACKR3/LTBR/IL20RB/XCR1/TNFRSF14/TNFRSF10D/CXCL2/IL6R/TNF/CCL20/IL18R1/CCL26/CCL2/TNFRSF10B/IL20RA/CCR7/IL18/CXCR4	23
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/2327	27/8135	0.921	1	0.8352	B4GALT2/A4GALT/B4GALT4/B3GALT2/FUT1	5
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/2327	89/8135	0.9228	1	0.8352	MAPK3/MAPK12/AKT2/EGF/MAPK11/MAP2K1/TRAF6/AKT3/STAT1/CD274/MAP2K6/CSNK2A1/NRAS/PPP3CC/HRAS/MYD88/MAP3K3/CSNK2A3/PLCG1/KRAS	20
KEGG	hsa00140	Steroid hormone biosynthesis	13/2327	61/8135	0.9239	1	0.8352	AKR1C1/AKR1C2/HSD17B7/HSD11B1L/STS/CYP1B1/HSD17B6/AKR1C3/LRTOMT/HSD17B8/CYP17A1/HSD17B12/SRD5A1	13
KEGG	hsa00500	Starch and sucrose metabolism	7/2327	36/8135	0.9247	1	0.8352	GAA/HKDC1/PGM2L1/PGM1/AGL/AMY2B/PGM2	7
KEGG	hsa04672	Intestinal immune network for IgA production	10/2327	49/8135	0.9281	1	0.8352	IL6/CD40/TNFSF13/LTBR/ITGA4/HLA-DMA/IL15RA/ITGB7/CD80/CXCR4	10
KEGG	hsa03430	Mismatch repair	4/2327	23/8135	0.9293	1	0.8352	MLH3/POLD2/RPA4/PMS2	4
KEGG	hsa04914	Progesterone-mediated oocyte maturation	23/2327	102/8135	0.9323	1	0.8352	MAPK3/ADCY8/CPEB1/MAPK12/HSP90AB1/ADCY1/AKT2/MAPK11/MAP2K1/RPS6KA3/PGR/AKT3/CCNB3/ANAPC10/IGF1R/GNAI3/BRAF/ANAPC1/RPS6KA1/KRAS/GNAI2/CDC25B/HSP90AA1	23
KEGG	hsa04622	RIG-I-like receptor signaling pathway	15/2327	70/8135	0.9323	1	0.8352	IL12A/MAPK12/IRF7/SIKE1/MAPK11/MAP3K1/TRAF6/TRADD/TBKBP1/TRAF3/TNF/IFIH1/ATG12/DHX58/IRF3	15
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/2327	223/8135	0.9408	1	0.8352	NOX4/MAPK3/AKR1C1/PLD1/GSTO1/MAPK12/VEGFA/SDHA/AKR1C2/SLC25A4/AKT2/EGF/ABL1/MAP2K7/MAPK11/MAP2K1/CYP1B1/PTPRJ/AKT3/KEAP1/AKR1C3/EPHX2/EPHX1/PRKD1/VDAC2/ARNT/SOS1/PTK2/GSTM4/NDUFA12/GSTA1/NRAS/MET/BAD/PLD2/HRAS/MGST1/NDUFA5/VDAC1/ACP1/BRAF/NDUFC1/UQCRH/ABL2/NDUFV3/MGST3/HGF/GSTM2/KRAS/NCF2/COX7A2/NDUFB9/SDHB/SOD2	54
KEGG	hsa00051	Fructose and mannose metabolism	6/2327	33/8135	0.9417	1	0.8352	PFKFB2/HKDC1/PMM2/FBP1/ENOSF1/ALDOC	6
KEGG	hsa04060	Cytokine-cytokine receptor interaction	73/2327	295/8135	0.9422	1	0.8352	CCR1/TNFRSF11B/IL1RL2/IL6/IL12A/NGF/IL27RA/CCR3/TNFSF15/TGFB3/ACVR2B/IL22RA1/IL7/IL1R1/IL16/TGFBR2/CLCF1/CD40/IL1R2/INHBE/GDF5/ACVR1/EDA/CSF1/BMP2/IL1RAP/ACKR3/TNFSF13/LTBR/IL20RB/XCR1/IL31RA/BMP6/TNFRSF14/IL23A/IL1B/IL11RA/FAS/IL11/TNFRSF10D/IL15RA/CXCL2/IL6R/IL1A/LIF/TGFBR1/TNF/TNFSF9/CSF2RB/CCL20/IL17B/TNFRSF21/INHBA/IL18R1/CCL26/CCL2/NODAL/TNFRSF10B/TNFRSF9/TNFRSF11A/TNFSF11/PRL/INHBB/IL20RA/IL26/IL32/IL12RB1/CCR7/IL18/CXCR4/TNFRSF12A/THPO/IL36RN	73
KEGG	hsa04658	Th1 and Th2 cell differentiation	20/2327	92/8135	0.9464	1	0.8352	MAPK3/IL12A/MAPK12/STAT5A/MAPK11/MAF/STAT1/STAT6/HLA-DMA/JAG1/MAML1/NOTCH2/MAML3/PPP3CC/MAML2/STAT4/STAT5B/DLL3/IL12RB1/PLCG1	20
KEGG	hsa00591	Linoleic acid metabolism	5/2327	29/8135	0.9475	1	0.8352	CYP2C8/PLA2G4A/PLA2G2A/PLA2G6/PLA2G4C	5
KEGG	hsa04970	Salivary secretion	20/2327	93/8135	0.9527	1	0.8352	BST1/ADCY8/ATP1A2/ADCY1/DMBT1/ATP1A3/GNAQ/ATP1B2/KCNMA1/AMY2B/PLCB2/ATP1A1/ADRA1D/PRKCB/ITPR2/CST2/AQP5/ITPR1/LYZL1/ATP2B4	20
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/2327	25/8135	0.9547	1	0.8352	PLA2G4A/PLA2G2A/PLA2G6/PLA2G4C	4
KEGG	hsa03010	Ribosome	36/2327	158/8135	0.9601	1	0.8352	RPS27A/MRPL3/RPL27/RPL24/RPL22L1/RPL21/RPL6/MRPL21/RPL36/MRPL14/RPS12/RSL24D1/MRPL19/RPL26L1/MRPS6/MRPL24/RPS21/MRPL17/MRPL36/MRPL15/MRPL13/RPL17/RPL32/RPS7/RPL22/RPS10/RPL35A/MRPL18/RPL11/RPS13/FAU/RPL35/RPL38/MRPL27/RPL41/RPL23A	36
KEGG	hsa04660	T cell receptor signaling pathway	22/2327	104/8135	0.9673	1	0.8352	VAV3/MAPK3/MAPK12/AKT2/MAP2K7/MAPK11/MAP2K1/MAP3K8/AKT3/SOS1/DLG1/NRAS/CDC42/PPP3CC/HRAS/TNF/RHOA/NCK2/PTPRC/PAK2/PLCG1/KRAS	22
KEGG	hsa04976	Bile secretion	18/2327	89/8135	0.9731	1	0.8352	ADCY8/ABCC4/ATP1A2/AQP9/ADCY1/ATP1A3/EPHX1/NCEH1/ATP1B2/SLC2A1/CA2/SLC4A4/CFTR/ABCC2/ATP1A1/RXRA/SCTR/ABCB11	18
KEGG	hsa04742	Taste transduction	17/2327	86/8135	0.9773	1	0.8352	ADCY8/PDE1C/PDE1A/SCN3A/CACNA1C/GABBR2/SCNN1A/PLCB2/GABRA4/TAS2R14/TAS2R5/HTR3E/TAS2R3/TAS2R9/P2RY1/GNB3/PDE1B	17
KEGG	hsa05415	Diabetic cardiomyopathy	46/2327	203/8135	0.9779	1	0.8352	PDK2/PDK4/COL1A1/CPT2/MAPK12/ATP2A3/SDHA/TGFB3/GFPT1/PRKCZ/SLC25A4/TGFBR2/AGTR1/AKT2/GFPT2/MAPK11/RYR2/AKT3/PPARA/CD36/VDAC2/INSR/MMP2/NDUFA12/SLC2A1/CAMK2A/TGFBR1/PLCB2/PDHB/NDUFA5/VDAC1/PRKCB/NDUFC1/GAPDH/GSR/UQCRH/NDUFV3/PDHA1/SP1/NCF2/RAC2/COL1A2/COX7A2/NDUFB9/SDHB/SLC2A4	46
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/2327	23/8135	0.9782	1	0.8352	POMK/B4GALT2/POMGNT2	3
KEGG	hsa05340	Primary immunodeficiency	6/2327	38/8135	0.9789	1	0.8352	CD40/RAG1/RFXAP/PTPRC/CD19/RAG2	6
KEGG	hsa04723	Retrograde endocannabinoid signaling	32/2327	148/8135	0.979	1	0.8352	GNB5/MAPK3/ADCY8/PTGS2/MAPK12/GNG7/ADCY1/MAPK11/GRIA1/GNG12/CACNA1C/GNB4/ABHD6/GNAQ/NDUFA12/PLCB2/NDUFA5/GABRA4/DAGLB/GNB1/GNAI3/PRKCB/NDUFC1/ITPR2/RIMS1/ITPR1/GRIA3/NDUFV3/GNB3/GNAI2/NDUFB9/CACNA1F	32
KEGG	hsa00860	Porphyrin metabolism	7/2327	43/8135	0.9802	1	0.8352	CP/GUSB/HCCS/FXN/ALAD/COX10/HMOX2	7
KEGG	hsa04744	Phototransduction	4/2327	29/8135	0.9823	1	0.8352	GNAT2/GNB1/GUCY2F/SLC24A1	4
KEGG	hsa05310	Asthma	4/2327	31/8135	0.9891	1	0.8352	CD40/HLA-DMA/TNF/EPX	4
KEGG	hsa04110	Cell cycle	25/2327	126/8135	0.991	1	0.8352	CDKN1C/TGFB3/CDK6/TFDP2/YWHAB/ABL1/WEE1/RBL2/MYC/CCNH/CCNB3/ANAPC10/GADD45B/CDK7/STAG1/GADD45G/SMC1B/CREBBP/YWHAZ/ORC4/HDAC2/CCND2/ANAPC1/CCND1/CDC25B	25
KEGG	hsa05320	Autoimmune thyroid disease	8/2327	53/8135	0.9933	1	0.8352	CD40/HLA-E/HLA-G/HLA-DMA/FAS/HLA-C/CGA/CD80	8
KEGG	hsa05033	Nicotine addiction	5/2327	40/8135	0.9957	1	0.8352	GRIA1/GRIN2A/GRIN2D/GABRA4/GRIA3	5
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/2327	30/8135	0.9967	1	0.8352	GUSB/ALDH3A2/ALDH1B1	3
KEGG	hsa04114	Oocyte meiosis	24/2327	131/8135	0.9977	1	0.8352	MAPK3/ADCY8/CPEB1/MAPK12/ADCY1/YWHAB/MAPK11/MAP2K1/STAG3/RPS6KA3/PGR/ANAPC10/IGF1R/PPP3CC/CAMK2A/SMC1B/PPP2R1A/YWHAZ/ITPR2/ITPR1/ANAPC1/PPP2R5D/RPS6KA1/SLK	24
KEGG	hsa00830	Retinol metabolism	10/2327	68/8135	0.9978	1	0.8352	ALDH1A2/HSD17B6/DGAT1/CYP2C8/ADH7/DHRS9/AOX1/PNPLA4/RDH13/CYP2A7	10
KEGG	hsa05206	MicroRNAs in cancer	67/2327	310/8135	0.9982	1	0.8352	BCL2/MAPK3/ITGB3/PTGS2/BCL2L11/VEGFA/HDAC4/PIM1/CDK6/SOX4/SLC7A1/MIR99A/BMF/ABL1/DICER1/MIRLET7A2/MAP2K1/THBS1/CYP1B1/MIR125B2/MYC/SHC1/DNMT3B/MMP16/DDIT4/PDGFRB/ZEB2/PRKCE/TPM1/MIR106B/MIR103A1/MIR100/EFNA5/HDAC5/BAK1/SOS1/EFNA4/CYP24A1/NOTCH2/ITGA5/NRAS/MET/ROCK1/HRAS/MIR199A1/CREBBP/CCNG1/ABCC1/PRKCB/MIR199A2/PDCD4/FOXP1/IGF2BP1/RHOA/HDAC2/EFNA3/CCND2/MIR181C/APC2/MIR101-1/CCND1/PLCG1/KRAS/MIR326/ERBB2/CDC25B/IRS2	67
KEGG	hsa00040	Pentose and glucuronate interconversions	3/2327	34/8135	0.9989	1	0.8352	GUSB/DHDH/RPE	3
KEGG	hsa03030	DNA replication	3/2327	36/8135	0.9994	1	0.8352	RNASEH1/POLD2/RPA4	3
KEGG	hsa04714	Thermogenesis	45/2327	232/8135	0.9996	1	0.8352	PRKAG3/SMARCA2/CREB5/ADCY8/PPARG/CPT2/MAPK12/SMARCC2/CREB3L4/CREB3L1/SDHA/KDM3A/KDM3B/TSC2/ADCY1/NDUFAF2/CREB3/NDUFAF4/MAPK11/PNPLA2/RPS6KA3/COA4/TSC1/PPARGC1A/ARID1B/SOS1/SLC25A29/NDUFA12/SMARCE1/NRAS/PRKAB1/DPF1/COX10/HRAS/COA5/NDUFA5/NDUFC1/UQCRH/NDUFV3/RPS6KA1/ACSL6/KRAS/COX7A2/NDUFB9/SDHB	45
KEGG	hsa05034	Alcoholism	34/2327	187/8135	0.9997	1	0.8352	GNB5/BDNF/CREB5/MAPK3/CREB3L4/CREB3L1/GNG7/HDAC4/SLC29A3/CREB3/MAP2K1/ATF4/ATF6B/SHC1/GNG12/GNB4/GRIN2A/HDAC5/SOS1/ADORA2A/NRAS/DRD2/SLC18A2/GRIN2D/HRAS/GNB1/GNAI3/BRAF/SHC2/HDAC2/HDAC6/GNB3/KRAS/GNAI2	34
KEGG	hsa04950	Maturity onset diabetes of the young	1/2327	26/8135	0.9998	1	0.8352	BHLHA15	1
KEGG	hsa03440	Homologous recombination	3/2327	41/8135	0.9999	1	0.8352	POLD2/RPA4/SYCP3	3
KEGG	hsa00190	Oxidative phosphorylation	21/2327	134/8135	0.9999	1	0.8352	SDHA/ATP6V1B2/ATP6V0A1/TCIRG1/LHPP/ATP6V1G3/ATP6V1C1/ATP6V1A/NDUFA12/COX10/ATP6V0D1/NDUFA5/NDUFC1/UQCRH/NDUFV3/ATP6V1F/ATP6V0E2/COX7A2/NDUFB9/SDHB/ATP6V1E1	21
KEGG	hsa03460	Fanconi anemia pathway	5/2327	54/8135	0.9999	1	0.8352	FANCF/WDR48/ERCC1/RPA4/PMS2	5
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	6/2327	66/8135	1	1	0.8352	SARS2/YARS2/SEPSECS/FARSB/WARS2/RARS2	6
KEGG	hsa04613	Neutrophil extracellular trap formation	31/2327	190/8135	1	1	0.8352	MAPK3/ITGB3/MAPK12/FCGR2A/HDAC4/AQP9/SLC25A4/AKT2/GSDMD/MAPK11/MAP2K1/CASP1/AKT3/HDAC5/VDAC2/TLR7/FPR3/PLCB2/VDAC1/CASP4/PRKCB/ATG7/HDAC2/HDAC6/SYK/TLR8/VWF/ELANE/PLCG1/NCF2/RAC2	31
KEGG	hsa05322	Systemic lupus erythematosus	17/2327	136/8135	1	1	0.8352	SSB/C2/ACTN1/FCGR2A/CD40/SNRPD3/C7/HLA-DMA/C8G/GRIN2A/C1R/C1S/SNRPD1/TNF/TRIM21/ELANE/CD80	17
KEGG	hsa04080	Neuroactive ligand-receptor interaction	57/2327	353/8135	1	1	0.8352	PTGER4/P2RX7/ADM2/PTGIR/PRSS3/LPAR1/LPAR6/EDNRB/SSTR1/AGTR1/F2RL2/THRA/GRIK5/NR3C1/GRIA1/F2R/LYPD6B/NMB/EDN1/VIP/CALCRL/P2RY6/NPY4R/GRIN2A/GRIK1/CHRNB1/F2RL1/TBXA2R/GABBR2/P2RX4/ADORA2A/DRD2/GRIN2D/HCRTR2/CNR2/GRM8/OPRK1/FPR3/GABRA4/AVPR2/BDKRB2/ADRA1D/S1PR1/TRPV1/UCN2/EDNRA/GRM3/GRIA3/PRL/CGA/OXTR/SCTR/NMUR1/P2RY1/CALCA/MC1R/P2RX5	57
KEGG	hsa04740	Olfactory transduction	17/2327	440/8135	1	1	0.8352	ARRB1/PDE1C/GNG7/PDE1A/SLC8A1/SLC24A4/GNAL/ARRB2/CAMK2A/RGS2/GNB1/OR2A12/OR6J1/OR10A5/OR2A5/NCALD/PDE1B	17