ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa00430 Taurine and hypotaurine metabolism 3/116 16/8135 0.001382 0.2225 0.211 GADL1/FMO4/GGT5 3 KEGG hsa01210 2-Oxocarboxylic acid metabolism 3/116 19/8135 0.002317 0.2225 0.211 ACO2/IDH3G/NAGS 3 KEGG hsa04917 Prolactin signaling pathway 5/116 70/8135 0.00313 0.2225 0.211 SHC1/INS/STAT5A/TNFSF11/AKT3 5 KEGG hsa04914 Progesterone-mediated oocyte maturation 6/116 102/8135 0.003272 0.2225 0.211 BUB1/ADCY8/PKMYT1/INS/ANAPC2/AKT3 6 KEGG hsa01230 Biosynthesis of amino acids 5/116 75/8135 0.004219 0.2295 0.2176 ALDOC/ACO2/IDH3G/SDSL/NAGS 5 KEGG hsa04072 Phospholipase D signaling pathway 7/116 148/8135 0.005117 0.232 0.2199 SHC1/ADCY8/GRM6/SPHK1/INS/PIK3R6/AKT3 7 KEGG hsa05010 Alzheimer disease 12/116 384/8135 0.0084 0.3156 0.2992 NDUFB8/APH1A/TUBB/INS/SLC25A4/UQCRC1/EIF2S1/SLC39A11/PSMC1/GRIN2A/DVL1/AKT3 12 KEGG hsa00410 beta-Alanine metabolism 3/116 31/8135 0.009496 0.3156 0.2992 ACADS/GADL1/CNDP2 3 KEGG hsa05164 Influenza A 7/116 171/8135 0.01099 0.3156 0.2992 SLC25A4/IFNA10/EIF2S1/IL33/HLA-DMA/OAS2/AKT3 7 KEGG hsa04213 Longevity regulating pathway - multiple species 4/116 62/8135 0.0116 0.3156 0.2992 HSPA2/ADCY8/INS/AKT3 4 KEGG hsa04371 Apelin signaling pathway 6/116 139/8135 0.0143 0.3191 0.3025 ADCY8/SPHK1/PIK3R6/MYL2/ACTA2/AKT3 6 KEGG hsa05162 Measles 6/116 139/8135 0.0143 0.3191 0.3025 HSPA2/IFNA10/EIF2S1/STAT5A/OAS2/AKT3 6 KEGG hsa04140 Autophagy - animal 6/116 141/8135 0.01525 0.3191 0.3025 CAMKK2/ATG12/INS/EIF2S1/PRAP1/AKT3 6 KEGG hsa05224 Breast cancer 6/116 147/8135 0.01837 0.34 0.3224 SHC1/SP1/DVL1/TNFSF11/FGF10/AKT3 6 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/116 15/8135 0.01875 0.34 0.3224 ST8SIA5/B3GALT4 2 KEGG hsa01200 Carbon metabolism 5/116 115/8135 0.024 0.408 0.3869 ALDOC/ACO2/ACADS/IDH3G/SDSL 5 KEGG hsa04935 Growth hormone synthesis, secretion and action 5/116 119/8135 0.02732 0.4337 0.4112 SHC1/ADCY8/IGFALS/STAT5A/AKT3 5 KEGG hsa04015 Rap1 signaling pathway 7/116 210/8135 0.03023 0.4337 0.4112 ADCY8/INS/RAPGEF1/GRIN2A/FGF10/F2RL3/AKT3 7 KEGG hsa04611 Platelet activation 5/116 124/8135 0.03187 0.4337 0.4112 ROCK1/ADCY8/PIK3R6/F2RL3/AKT3 5 KEGG hsa04022 cGMP-PKG signaling pathway 6/116 167/8135 0.03189 0.4337 0.4112 ROCK1/ADCY8/INS/SLC25A4/PIK3R6/AKT3 6 KEGG hsa04211 Longevity regulating pathway 4/116 89/8135 0.03798 0.4757 0.451 CAMKK2/ADCY8/INS/AKT3 4 KEGG hsa04114 Oocyte meiosis 5/116 131/8135 0.03899 0.4757 0.451 BUB1/ADCY8/PKMYT1/INS/ANAPC2 5 KEGG hsa05020 Prion disease 8/116 273/8135 0.04094 0.4757 0.451 HSPA2/NDUFB8/TUBB/SLC25A4/UQCRC1/EIF2S1/PSMC1/GRIN2A 8 KEGG hsa04964 Proximal tubule bicarbonate reclamation 2/116 23/8135 0.04197 0.4757 0.451 SLC25A10/SLC9A3 2 KEGG hsa04923 Regulation of lipolysis in adipocytes 3/116 56/8135 0.04537 0.4919 0.4664 ADCY8/INS/AKT3 3 KEGG hsa04915 Estrogen signaling pathway 5/116 138/8135 0.04702 0.4919 0.4664 HSPA2/SHC1/ADCY8/SP1/AKT3 5 KEGG hsa00480 Glutathione metabolism 3/116 58/8135 0.0495 0.4959 0.4702 GGT5/GCLC/GSTA1 3 KEGG hsa01522 Endocrine resistance 4/116 98/8135 0.05105 0.4959 0.4702 SHC1/ADCY8/SP1/AKT3 4 KEGG hsa05017 Spinocerebellar ataxia 5/116 143/8135 0.05331 0.5 0.4741 SLC25A4/SP1/PSMC1/GRIN2A/AKT3 5 KEGG hsa00650 Butanoate metabolism 2/116 28/8135 0.0599 0.502 0.476 ACADS/ACSM2A 2 KEGG hsa05226 Gastric cancer 5/116 149/8135 0.06148 0.502 0.476 SHC1/REG4/DVL1/FGF10/AKT3 5 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 5/116 150/8135 0.06291 0.502 0.476 ADCY8/PIK3R6/MYL2/TPM2/AKT3 5 KEGG hsa04927 Cortisol synthesis and secretion 3/116 65/8135 0.0653 0.502 0.476 ADCY8/MC2R/SP1 3 KEGG hsa04510 Focal adhesion 6/116 201/8135 0.06718 0.502 0.476 SHC1/ROCK1/CHAD/RAPGEF1/MYL2/AKT3 6 KEGG hsa00020 Citrate cycle (TCA cycle) 2/116 30/8135 0.06769 0.502 0.476 ACO2/IDH3G 2 KEGG hsa01523 Antifolate resistance 2/116 30/8135 0.06769 0.502 0.476 GGH/TYMS 2 KEGG hsa05415 Diabetic cardiomyopathy 6/116 203/8135 0.06977 0.502 0.476 NDUFB8/INS/SLC25A4/UQCRC1/SP1/AKT3 6 KEGG hsa04932 Non-alcoholic fatty liver disease 5/116 155/8135 0.07032 0.502 0.476 NDUFB8/INS/UQCRC1/EIF2S1/AKT3 5 KEGG hsa05160 Hepatitis C 5/116 157/8135 0.07342 0.502 0.476 CLDN15/IFNA10/EIF2S1/OAS2/AKT3 5 KEGG hsa05014 Amyotrophic lateral sclerosis 9/116 364/8135 0.0751 0.502 0.476 NDUFB8/VCP/TUBB/UQCRC1/EIF2S1/PSMC1/GRIN2A/TPR/CHCHD10 9 KEGG hsa05145 Toxoplasmosis 4/116 112/8135 0.07567 0.502 0.476 HSPA2/PIK3R6/HLA-DMA/AKT3 4 KEGG hsa04630 JAK-STAT signaling pathway 5/116 162/8135 0.08148 0.5194 0.4925 IL9R/CNTFR/IFNA10/STAT5A/AKT3 5 KEGG hsa05207 Chemical carcinogenesis - receptor activation 6/116 212/8135 0.08212 0.5194 0.4925 ADCY8/STAT5A/TNFSF11/GSTA1/FGF10/AKT3 6 KEGG hsa05012 Parkinson disease 7/116 266/8135 0.08533 0.5224 0.4953 NDUFB8/TUBB/SLC25A4/UQCRC1/EIF2S1/SLC39A11/PSMC1 7 KEGG hsa04071 Sphingolipid signaling pathway 4/116 119/8135 0.08987 0.5224 0.4953 ROCK1/SPHK1/DEGS2/AKT3 4 KEGG hsa00512 Mucin type O-glycan biosynthesis 2/116 36/8135 0.09285 0.5224 0.4953 GALNT16/GALNT8 2 KEGG hsa05220 Chronic myeloid leukemia 3/116 76/8135 0.09414 0.5224 0.4953 SHC1/STAT5A/AKT3 3 KEGG hsa05166 Human T-cell leukemia virus 1 infection 6/116 222/8135 0.09719 0.5224 0.4953 ADCY8/SLC25A4/STAT5A/ANAPC2/HLA-DMA/AKT3 6 KEGG hsa01250 Biosynthesis of nucleotide sugars 2/116 37/8135 0.09727 0.5224 0.4953 NAGK/MIOX 2 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 2/116 37/8135 0.09727 0.5224 0.4953 HSD11B2/INS 2 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 6/116 223/8135 0.09877 0.5224 0.4953 NDUFB8/SLC25A4/UQCRC1/SLC26A6/GSTA1/AKT3 6 KEGG hsa04612 Antigen processing and presentation 3/116 78/8135 0.09987 0.5224 0.4953 HSPA2/KIR2DL3/HLA-DMA 3 KEGG hsa04926 Relaxin signaling pathway 4/116 129/8135 0.1122 0.5724 0.5428 SHC1/ADCY8/ACTA2/AKT3 4 KEGG hsa04014 Ras signaling pathway 6/116 232/8135 0.1136 0.5724 0.5428 SHC1/INS/PLA2G6/GRIN2A/FGF10/AKT3 6 KEGG hsa05332 Graft-versus-host disease 2/116 42/8135 0.1202 0.586 0.5556 KIR2DL3/HLA-DMA 2 KEGG hsa04012 ErbB signaling pathway 3/116 85/8135 0.121 0.586 0.5556 SHC1/STAT5A/AKT3 3 KEGG hsa04270 Vascular smooth muscle contraction 4/116 134/8135 0.1242 0.586 0.5556 ROCK1/ADCY8/ACTA2/PLA2G6 4 KEGG hsa04940 Type I diabetes mellitus 2/116 43/8135 0.125 0.586 0.5556 INS/HLA-DMA 2 KEGG hsa04260 Cardiac muscle contraction 3/116 87/8135 0.1273 0.5868 0.5563 UQCRC1/MYL2/TPM2 3 KEGG hsa04910 Insulin signaling pathway 4/116 137/8135 0.1317 0.5962 0.5652 SHC1/INS/RAPGEF1/AKT3 4 KEGG hsa04976 Bile secretion 3/116 89/8135 0.1337 0.5962 0.5652 ADCY8/SLC51A/SLC9A3 3 KEGG hsa04062 Chemokine signaling pathway 5/116 192/8135 0.1391 0.6101 0.5784 SHC1/ROCK1/ADCY8/PIK3R6/AKT3 5 KEGG hsa00514 Other types of O-glycan biosynthesis 2/116 47/8135 0.1443 0.6232 0.5909 GALNT16/GALNT8 2 KEGG hsa05414 Dilated cardiomyopathy 3/116 96/8135 0.157 0.6457 0.6122 ADCY8/MYL2/TPM2 3 KEGG hsa03040 Spliceosome 4/116 147/8135 0.1578 0.6457 0.6122 HSPA2/PPIE/CTNNBL1/PRPF8 4 KEGG hsa04666 Fc gamma R-mediated phagocytosis 3/116 97/8135 0.1605 0.6457 0.6122 SPHK1/PLA2G6/AKT3 3 KEGG hsa05169 Epstein-Barr virus infection 5/116 202/8135 0.1614 0.6457 0.6122 IFNA10/PSMC1/HLA-DMA/OAS2/AKT3 5 KEGG hsa00270 Cysteine and methionine metabolism 2/116 51/8135 0.1643 0.6457 0.6122 SDSL/GCLC 2 KEGG hsa04913 Ovarian steroidogenesis 2/116 51/8135 0.1643 0.6457 0.6122 ADCY8/INS 2 KEGG hsa00600 Sphingolipid metabolism 2/116 52/8135 0.1694 0.6457 0.6122 SPHK1/DEGS2 2 KEGG hsa05320 Autoimmune thyroid disease 2/116 53/8135 0.1745 0.6457 0.6122 IFNA10/HLA-DMA 2 KEGG hsa04921 Oxytocin signaling pathway 4/116 154/8135 0.1772 0.6457 0.6122 ROCK1/CAMKK2/ADCY8/PIK3R6 4 KEGG hsa04934 Cushing syndrome 4/116 155/8135 0.18 0.6457 0.6122 ADCY8/MC2R/SP1/DVL1 4 KEGG hsa04150 mTOR signaling pathway 4/116 156/8135 0.1828 0.6457 0.6122 INS/NPRL2/DVL1/AKT3 4 KEGG hsa04217 Necroptosis 4/116 159/8135 0.1915 0.6457 0.6122 SLC25A4/IFNA10/STAT5A/IL33 4 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 3/116 106/8135 0.1923 0.6457 0.6122 ADCY8/SP1/TNFSF11 3 KEGG hsa01212 Fatty acid metabolism 2/116 57/8135 0.1951 0.6457 0.6122 ACADS/ELOVL5 2 KEGG hsa05134 Legionellosis 2/116 57/8135 0.1951 0.6457 0.6122 HSPA2/VCP 2 KEGG hsa03013 Nucleocytoplasmic transport 3/116 108/8135 0.1996 0.6457 0.6122 UBE2I/UPF2/TPR 3 KEGG hsa04066 HIF-1 signaling pathway 3/116 109/8135 0.2033 0.6457 0.6122 ALDOC/INS/AKT3 3 KEGG hsa04330 Notch signaling pathway 2/116 59/8135 0.2055 0.6457 0.6122 APH1A/DVL1 2 KEGG hsa04370 VEGF signaling pathway 2/116 59/8135 0.2055 0.6457 0.6122 SPHK1/AKT3 2 KEGG hsa04024 cAMP signaling pathway 5/116 221/8135 0.2076 0.6457 0.6122 ROCK1/ADCY8/MC2R/GRIN2A/AKT3 5 KEGG hsa04978 Mineral absorption 2/116 60/8135 0.2107 0.6457 0.6122 SLC26A6/SLC9A3 2 KEGG hsa00590 Arachidonic acid metabolism 2/116 61/8135 0.2159 0.6457 0.6122 PLA2G6/GGT5 2 KEGG hsa05163 Human cytomegalovirus infection 5/116 225/8135 0.2178 0.6457 0.6122 ROCK1/ADCY8/IFNA10/SP1/AKT3 5 KEGG hsa05225 Hepatocellular carcinoma 4/116 168/8135 0.2181 0.6457 0.6122 SHC1/DVL1/GSTA1/AKT3 4 KEGG hsa04725 Cholinergic synapse 3/116 113/8135 0.2181 0.6457 0.6122 ADCY8/PIK3R6/AKT3 3 KEGG hsa04530 Tight junction 4/116 169/8135 0.2211 0.6457 0.6122 ROCK1/CLDN15/MYL2/MICALL2 4 KEGG hsa04670 Leukocyte transendothelial migration 3/116 114/8135 0.2218 0.6457 0.6122 ROCK1/CLDN15/MYL2 3 KEGG hsa04724 Glutamatergic synapse 3/116 114/8135 0.2218 0.6457 0.6122 ADCY8/GRM6/GRIN2A 3 KEGG hsa04623 Cytosolic DNA-sensing pathway 2/116 63/8135 0.2265 0.6457 0.6122 IFNA10/IL33 2 KEGG hsa04141 Protein processing in endoplasmic reticulum 4/116 171/8135 0.2272 0.6457 0.6122 HSPA2/VCP/EIF2S1/RNF5 4 KEGG hsa00511 Other glycan degradation 1/116 18/8135 0.228 0.6457 0.6122 AGA 1 KEGG hsa04929 GnRH secretion 2/116 64/8135 0.2317 0.6457 0.6122 HCN3/AKT3 2 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 9/116 476/8135 0.2378 0.6457 0.6122 NDUFB8/VCP/TUBB/SLC25A4/UQCRC1/EIF2S1/PSMC1/GRIN2A/DVL1 9 KEGG hsa04722 Neurotrophin signaling pathway 3/116 119/8135 0.2407 0.6457 0.6122 SHC1/RAPGEF1/AKT3 3 KEGG hsa04060 Cytokine-cytokine receptor interaction 6/116 295/8135 0.2445 0.6457 0.6122 IL9R/CNTFR/IFNA10/IL33/TNFSF11/ACVRL1 6 KEGG hsa04152 AMPK signaling pathway 3/116 120/8135 0.2446 0.6457 0.6122 CAMKK2/INS/AKT3 3 KEGG hsa04720 Long-term potentiation 2/116 67/8135 0.2476 0.6457 0.6122 ADCY8/GRIN2A 2 KEGG hsa05221 Acute myeloid leukemia 2/116 67/8135 0.2476 0.6457 0.6122 STAT5A/AKT3 2 KEGG hsa00670 One carbon pool by folate 1/116 20/8135 0.2499 0.6457 0.6122 TYMS 1 KEGG hsa05152 Tuberculosis 4/116 180/8135 0.255 0.6457 0.6122 SPHK1/IFNA10/HLA-DMA/AKT3 4 KEGG hsa04020 Calcium signaling pathway 5/116 240/8135 0.2575 0.6457 0.6122 ADCY8/SPHK1/SLC25A4/GRIN2A/FGF10 5 KEGG hsa04920 Adipocytokine signaling pathway 2/116 69/8135 0.2582 0.6457 0.6122 CAMKK2/AKT3 2 KEGG hsa05211 Renal cell carcinoma 2/116 69/8135 0.2582 0.6457 0.6122 RAPGEF1/AKT3 2 KEGG hsa00770 Pantothenate and CoA biosynthesis 1/116 21/8135 0.2606 0.6457 0.6122 GADL1 1 KEGG hsa04622 RIG-I-like receptor signaling pathway 2/116 70/8135 0.2635 0.6457 0.6122 ATG12/IFNA10 2 KEGG hsa04110 Cell cycle 3/116 126/8135 0.2676 0.6457 0.6122 BUB1/PKMYT1/ANAPC2 3 KEGG hsa05016 Huntington disease 6/116 306/8135 0.271 0.6457 0.6122 NDUFB8/TUBB/SLC25A4/UQCRC1/SP1/PSMC1 6 KEGG hsa00220 Arginine biosynthesis 1/116 22/8135 0.2712 0.6457 0.6122 NAGS 1 KEGG hsa00340 Histidine metabolism 1/116 22/8135 0.2712 0.6457 0.6122 CNDP2 1 KEGG hsa00982 Drug metabolism - cytochrome P450 2/116 72/8135 0.2741 0.6457 0.6122 FMO4/GSTA1 2 KEGG hsa05218 Melanoma 2/116 72/8135 0.2741 0.6457 0.6122 FGF10/AKT3 2 KEGG hsa05223 Non-small cell lung cancer 2/116 72/8135 0.2741 0.6457 0.6122 STAT5A/AKT3 2 KEGG hsa04380 Osteoclast differentiation 3/116 128/8135 0.2754 0.6457 0.6122 TNFSF11/CALCR/AKT3 3 KEGG hsa01524 Platinum drug resistance 2/116 73/8135 0.2794 0.6492 0.6155 GSTA1/AKT3 2 KEGG hsa03430 Mismatch repair 1/116 23/8135 0.2816 0.6492 0.6155 RFC5 1 KEGG hsa04068 FoxO signaling pathway 3/116 131/8135 0.2871 0.6507 0.6169 ATG12/INS/AKT3 3 KEGG hsa04650 Natural killer cell mediated cytotoxicity 3/116 131/8135 0.2871 0.6507 0.6169 SHC1/KIR2DL3/IFNA10 3 KEGG hsa05214 Glioma 2/116 75/8135 0.29 0.6508 0.6171 SHC1/AKT3 2 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/116 24/8135 0.2919 0.6508 0.6171 NDST4 1 KEGG hsa04971 Gastric acid secretion 2/116 76/8135 0.2953 0.6531 0.6192 ADCY8/ATP4A 2 KEGG hsa00190 Oxidative phosphorylation 3/116 134/8135 0.2988 0.6554 0.6214 NDUFB8/ATP4A/UQCRC1 3 KEGG hsa00592 alpha-Linolenic acid metabolism 1/116 25/8135 0.302 0.6572 0.6231 PLA2G6 1 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 2/116 78/8135 0.3059 0.6579 0.6238 GSTA1/AKR7A2 2 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 2/116 79/8135 0.3112 0.6579 0.6238 SHC1/AKT3 2 KEGG hsa00790 Folate biosynthesis 1/116 26/8135 0.312 0.6579 0.6238 GGH 1 KEGG hsa04950 Maturity onset diabetes of the young 1/116 26/8135 0.312 0.6579 0.6238 INS 1 KEGG hsa00062 Fatty acid elongation 1/116 27/8135 0.3219 0.6632 0.6288 ELOVL5 1 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 1/116 27/8135 0.3219 0.6632 0.6288 ELOVL5 1 KEGG hsa04966 Collecting duct acid secretion 1/116 27/8135 0.3219 0.6632 0.6288 ATP4A 1 KEGG hsa04120 Ubiquitin mediated proteolysis 3/116 142/8135 0.3301 0.6701 0.6353 CUL3/UBE2I/ANAPC2 3 KEGG hsa04936 Alcoholic liver disease 3/116 142/8135 0.3301 0.6701 0.6353 CAMKK2/IFNA10/AKT3 3 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 3/116 143/8135 0.334 0.6703 0.6355 HOXA1/DVL1/AKT3 3 KEGG hsa00591 Linoleic acid metabolism 1/116 29/8135 0.3411 0.6703 0.6355 PLA2G6 1 KEGG hsa04742 Taste transduction 2/116 86/8135 0.3478 0.6703 0.6355 ADCY8/TAS2R3 2 KEGG hsa04911 Insulin secretion 2/116 86/8135 0.3478 0.6703 0.6355 ADCY8/INS 2 KEGG hsa00030 Pentose phosphate pathway 1/116 30/8135 0.3506 0.6703 0.6355 ALDOC 1 KEGG hsa00053 Ascorbate and aldarate metabolism 1/116 30/8135 0.3506 0.6703 0.6355 MIOX 1 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 1/116 30/8135 0.3506 0.6703 0.6355 ACO2 1 KEGG hsa04540 Gap junction 2/116 88/8135 0.3582 0.6703 0.6355 ADCY8/TUBB 2 KEGG hsa05310 Asthma 1/116 31/8135 0.3598 0.6703 0.6355 HLA-DMA 1 KEGG hsa05417 Lipid and atherosclerosis 4/116 215/8135 0.3677 0.6703 0.6355 HSPA2/IFNA10/EIF2S1/AKT3 4 KEGG hsa05410 Hypertrophic cardiomyopathy 2/116 90/8135 0.3685 0.6703 0.6355 MYL2/TPM2 2 KEGG hsa00640 Propanoate metabolism 1/116 32/8135 0.369 0.6703 0.6355 ACADS 1 KEGG hsa04136 Autophagy - other 1/116 32/8135 0.369 0.6703 0.6355 ATG12 1 KEGG hsa04215 Apoptosis - multiple species 1/116 32/8135 0.369 0.6703 0.6355 BOK 1 KEGG hsa01240 Biosynthesis of cofactors 3/116 153/8135 0.3731 0.6703 0.6355 NMNAT1/GGH/GCLC 3 KEGG hsa04810 Regulation of actin cytoskeleton 4/116 218/8135 0.3775 0.6703 0.6355 ROCK1/INS/MYL2/FGF10 4 KEGG hsa00051 Fructose and mannose metabolism 1/116 33/8135 0.378 0.6703 0.6355 ALDOC 1 KEGG hsa04130 SNARE interactions in vesicular transport 1/116 33/8135 0.378 0.6703 0.6355 STX1B 1 KEGG hsa04658 Th1 and Th2 cell differentiation 2/116 92/8135 0.3788 0.6703 0.6355 STAT5A/HLA-DMA 2 KEGG hsa04970 Salivary secretion 2/116 93/8135 0.3839 0.6703 0.6355 CST3/ADCY8 2 KEGG hsa05323 Rheumatoid arthritis 2/116 93/8135 0.3839 0.6703 0.6355 TNFSF11/HLA-DMA 2 KEGG hsa04350 TGF-beta signaling pathway 2/116 94/8135 0.3889 0.6703 0.6355 ROCK1/SP1 2 KEGG hsa04080 Neuroactive ligand-receptor interaction 6/116 353/8135 0.39 0.6703 0.6355 GRM6/MC2R/HCRTR2/GRIN2A/F2RL3/CALCR 6 KEGG hsa04151 PI3K-Akt signaling pathway 6/116 354/8135 0.3926 0.6703 0.6355 INS/IFNA10/CHAD/PIK3R6/FGF10/AKT3 6 KEGG hsa04713 Circadian entrainment 2/116 97/8135 0.4041 0.6703 0.6355 ADCY8/GRIN2A 2 KEGG hsa05215 Prostate cancer 2/116 97/8135 0.4041 0.6703 0.6355 INS/AKT3 2 KEGG hsa00760 Nicotinate and nicotinamide metabolism 1/116 36/8135 0.4044 0.6703 0.6355 NMNAT1 1 KEGG hsa03030 DNA replication 1/116 36/8135 0.4044 0.6703 0.6355 RFC5 1 KEGG hsa05161 Hepatitis B 3/116 162/8135 0.408 0.6703 0.6355 IFNA10/STAT5A/AKT3 3 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 2/116 98/8135 0.4091 0.6703 0.6355 ADCY8/PLA2G6 2 KEGG hsa04925 Aldosterone synthesis and secretion 2/116 98/8135 0.4091 0.6703 0.6355 ADCY8/MC2R 2 KEGG hsa05231 Choline metabolism in cancer 2/116 98/8135 0.4091 0.6703 0.6355 SP1/AKT3 2 KEGG hsa05216 Thyroid cancer 1/116 37/8135 0.4129 0.6703 0.6355 TPR 1 KEGG hsa04640 Hematopoietic cell lineage 2/116 99/8135 0.4141 0.6703 0.6355 IL9R/HLA-DMA 2 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 2/116 100/8135 0.419 0.6703 0.6355 STAT5A/AKT3 2 KEGG hsa05330 Allograft rejection 1/116 38/8135 0.4213 0.6703 0.6355 HLA-DMA 1 KEGG hsa04714 Thermogenesis 4/116 232/8135 0.4229 0.6703 0.6355 ADCY8/NDUFB8/UQCRC1/COX14 4 KEGG hsa04916 Melanogenesis 2/116 101/8135 0.424 0.6703 0.6355 ADCY8/DVL1 2 KEGG hsa04972 Pancreatic secretion 2/116 102/8135 0.4289 0.6703 0.6355 ADCY8/CLCA1 2 KEGG hsa04974 Protein digestion and absorption 2/116 103/8135 0.4338 0.6703 0.6355 MEP1A/SLC9A3 2 KEGG hsa00260 Glycine, serine and threonine metabolism 1/116 40/8135 0.4378 0.6703 0.6355 SDSL 1 KEGG hsa05033 Nicotine addiction 1/116 40/8135 0.4378 0.6703 0.6355 GRIN2A 1 KEGG hsa04064 NF-kappa B signaling pathway 2/116 104/8135 0.4386 0.6703 0.6355 UBE2I/TNFSF11 2 KEGG hsa04620 Toll-like receptor signaling pathway 2/116 104/8135 0.4386 0.6703 0.6355 IFNA10/AKT3 2 KEGG hsa03440 Homologous recombination 1/116 41/8135 0.4458 0.6737 0.6388 BARD1 1 KEGG hsa04216 Ferroptosis 1/116 41/8135 0.4458 0.6737 0.6388 GCLC 1 KEGG hsa04659 Th17 cell differentiation 2/116 108/8135 0.4579 0.6824 0.647 STAT5A/HLA-DMA 2 KEGG hsa04931 Insulin resistance 2/116 108/8135 0.4579 0.6824 0.647 INS/AKT3 2 KEGG hsa00071 Fatty acid degradation 1/116 43/8135 0.4616 0.6824 0.647 ACADS 1 KEGG hsa04975 Fat digestion and absorption 1/116 43/8135 0.4616 0.6824 0.647 CLPS 1 KEGG hsa05131 Shigellosis 4/116 247/8135 0.4706 0.6919 0.6561 ROCK1/ATG12/MYL2/AKT3 4 KEGG hsa05132 Salmonella infection 4/116 249/8135 0.4769 0.6974 0.6612 FHOD1/TUBB/MYL2/AKT3 4 KEGG hsa03050 Proteasome 1/116 46/8135 0.4844 0.6991 0.6628 PSMC1 1 KEGG hsa04930 Type II diabetes mellitus 1/116 46/8135 0.4844 0.6991 0.6628 INS 1 KEGG hsa04621 NOD-like receptor signaling pathway 3/116 184/8135 0.4904 0.6991 0.6628 ATG12/IFNA10/OAS2 3 KEGG hsa03420 Nucleotide excision repair 1/116 47/8135 0.4918 0.6991 0.6628 RFC5 1 KEGG hsa04973 Carbohydrate digestion and absorption 1/116 47/8135 0.4918 0.6991 0.6628 AKT3 1 KEGG hsa00280 Valine, leucine and isoleucine degradation 1/116 48/8135 0.4991 0.6991 0.6628 ACADS 1 KEGG hsa05034 Alcoholism 3/116 187/8135 0.5012 0.6991 0.6628 SHC1/CAMKK2/GRIN2A 3 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 1/116 49/8135 0.5063 0.6991 0.6628 NAGK 1 KEGG hsa00565 Ether lipid metabolism 1/116 49/8135 0.5063 0.6991 0.6628 PLA2G6 1 KEGG hsa04672 Intestinal immune network for IgA production 1/116 49/8135 0.5063 0.6991 0.6628 HLA-DMA 1 KEGG hsa05030 Cocaine addiction 1/116 49/8135 0.5063 0.6991 0.6628 GRIN2A 1 KEGG hsa05165 Human papillomavirus infection 5/116 331/8135 0.5127 0.7017 0.6653 IFNA10/CHAD/PSMC1/DVL1/AKT3 5 KEGG hsa05110 Vibrio cholerae infection 1/116 50/8135 0.5134 0.7017 0.6653 KDELR2 1 KEGG hsa00330 Arginine and proline metabolism 1/116 51/8135 0.5204 0.7077 0.671 CNDP2 1 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 3/116 194/8135 0.526 0.7118 0.6749 IFNA10/PIK3R6/AKT3 3 KEGG hsa05130 Pathogenic Escherichia coli infection 3/116 197/8135 0.5364 0.7223 0.6849 ROCK1/CLDN15/TUBB 3 KEGG hsa04340 Hedgehog signaling pathway 1/116 56/8135 0.5538 0.7421 0.7036 CUL3 1 KEGG hsa04728 Dopaminergic synapse 2/116 132/8135 0.565 0.748 0.7093 GRIN2A/AKT3 2 KEGG hsa00240 Pyrimidine metabolism 1/116 58/8135 0.5665 0.748 0.7093 TYMS 1 KEGG hsa05213 Endometrial cancer 1/116 58/8135 0.5665 0.748 0.7093 AKT3 1 KEGG hsa05416 Viral myocarditis 1/116 60/8135 0.5789 0.7511 0.7121 HLA-DMA 1 KEGG hsa04210 Apoptosis 2/116 136/8135 0.5814 0.7511 0.7121 EIF2S1/AKT3 2 KEGG hsa05322 Systemic lupus erythematosus 2/116 136/8135 0.5814 0.7511 0.7121 GRIN2A/HLA-DMA 2 KEGG hsa00140 Steroid hormone biosynthesis 1/116 61/8135 0.5849 0.7511 0.7121 HSD11B2 1 KEGG hsa00561 Glycerolipid metabolism 1/116 61/8135 0.5849 0.7511 0.7121 MOGAT1 1 KEGG hsa05135 Yersinia infection 2/116 137/8135 0.5854 0.7511 0.7121 ROCK1/AKT3 2 KEGG hsa05418 Fluid shear stress and atherosclerosis 2/116 139/8135 0.5933 0.755 0.7159 GSTA1/AKT3 2 KEGG hsa00310 Lysine degradation 1/116 63/8135 0.5968 0.755 0.7159 PLOD1 1 KEGG hsa05217 Basal cell carcinoma 1/116 63/8135 0.5968 0.755 0.7159 DVL1 1 KEGG hsa05321 Inflammatory bowel disease 1/116 65/8135 0.6083 0.7631 0.7235 HLA-DMA 1 KEGG hsa04010 MAPK signaling pathway 4/116 294/8135 0.6088 0.7631 0.7235 HSPA2/INS/FGF10/AKT3 4 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/116 66/8135 0.6139 0.7632 0.7237 FARS2 1 KEGG hsa00010 Glycolysis / Gluconeogenesis 1/116 67/8135 0.6195 0.7632 0.7237 ALDOC 1 KEGG hsa04664 Fc epsilon RI signaling pathway 1/116 68/8135 0.6249 0.7632 0.7237 AKT3 1 KEGG hsa04723 Retrograde endocannabinoid signaling 2/116 148/8135 0.6277 0.7632 0.7237 ADCY8/NDUFB8 2 KEGG hsa04924 Renin secretion 1/116 69/8135 0.6303 0.7632 0.7237 CLCA1 1 KEGG hsa05031 Amphetamine addiction 1/116 69/8135 0.6303 0.7632 0.7237 GRIN2A 1 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 1/116 69/8135 0.6303 0.7632 0.7237 GSTA1 1 KEGG hsa04514 Cell adhesion molecules 2/116 149/8135 0.6314 0.7632 0.7237 CLDN15/HLA-DMA 2 KEGG hsa05230 Central carbon metabolism in cancer 1/116 70/8135 0.6357 0.765 0.7254 AKT3 1 KEGG hsa04145 Phagosome 2/116 152/8135 0.6422 0.7695 0.7296 TUBB/HLA-DMA 2 KEGG hsa04137 Mitophagy - animal 1/116 72/8135 0.6461 0.7707 0.7308 SP1 1 KEGG hsa00562 Inositol phosphate metabolism 1/116 73/8135 0.6512 0.7734 0.7333 MIOX 1 KEGG hsa04218 Cellular senescence 2/116 156/8135 0.6563 0.7751 0.7349 SLC25A4/AKT3 2 KEGG hsa03320 PPAR signaling pathway 1/116 75/8135 0.6611 0.7751 0.7349 FABP6 1 KEGG hsa04918 Thyroid hormone synthesis 1/116 75/8135 0.6611 0.7751 0.7349 ADCY8 1 KEGG hsa05212 Pancreatic cancer 1/116 76/8135 0.666 0.7764 0.7362 AKT3 1 KEGG hsa05100 Bacterial invasion of epithelial cells 1/116 77/8135 0.6708 0.7764 0.7362 SHC1 1 KEGG hsa05140 Leishmaniasis 1/116 77/8135 0.6708 0.7764 0.7362 HLA-DMA 1 KEGG hsa04721 Synaptic vesicle cycle 1/116 78/8135 0.6755 0.7786 0.7382 STX1B 1 KEGG hsa00983 Drug metabolism - other enzymes 1/116 80/8135 0.6848 0.786 0.7452 GSTA1 1 KEGG hsa04662 B cell receptor signaling pathway 1/116 82/8135 0.6938 0.793 0.7518 AKT3 1 KEGG hsa01232 Nucleotide metabolism 1/116 85/8135 0.7069 0.8011 0.7596 TYMS 1 KEGG hsa04610 Complement and coagulation cascades 1/116 85/8135 0.7069 0.8011 0.7596 F2RL3 1 KEGG hsa05210 Colorectal cancer 1/116 86/8135 0.7111 0.8026 0.761 AKT3 1 KEGG hsa05168 Herpes simplex virus 1 infection 6/116 495/8135 0.7167 0.8031 0.7615 IFNA10/EIF2S1/HLA-DMA/ZNF623/OAS2/AKT3 6 KEGG hsa04512 ECM-receptor interaction 1/116 88/8135 0.7194 0.8031 0.7615 CHAD 1 KEGG hsa04727 GABAergic synapse 1/116 89/8135 0.7234 0.8031 0.7615 ADCY8 1 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/116 89/8135 0.7234 0.8031 0.7615 AKT3 1 KEGG hsa05032 Morphine addiction 1/116 91/8135 0.7313 0.8086 0.7667 ADCY8 1 KEGG hsa05222 Small cell lung cancer 1/116 92/8135 0.7352 0.8096 0.7676 AKT3 1 KEGG hsa04912 GnRH signaling pathway 1/116 93/8135 0.739 0.8105 0.7685 ADCY8 1 KEGG hsa05150 Staphylococcus aureus infection 1/116 96/8135 0.7502 0.8191 0.7766 HLA-DMA 1 KEGG hsa03015 mRNA surveillance pathway 1/116 97/8135 0.7538 0.8191 0.7766 UPF2 1 KEGG hsa00564 Glycerophospholipid metabolism 1/116 98/8135 0.7573 0.8191 0.7766 PLA2G6 1 KEGG hsa04613 Neutrophil extracellular trap formation 2/116 190/8135 0.7588 0.8191 0.7766 SLC25A4/AKT3 2 KEGG hsa05142 Chagas disease 1/116 102/8135 0.771 0.8289 0.7859 AKT3 1 KEGG hsa04625 C-type lectin receptor signaling pathway 1/116 104/8135 0.7776 0.8294 0.7864 AKT3 1 KEGG hsa04660 T cell receptor signaling pathway 1/116 104/8135 0.7776 0.8294 0.7864 AKT3 1 KEGG hsa04922 Glucagon signaling pathway 1/116 107/8135 0.7871 0.835 0.7917 AKT3 1 KEGG hsa05203 Viral carcinogenesis 2/116 204/8135 0.7928 0.835 0.7917 STAT5A/PSMC1 2 KEGG hsa03008 Ribosome biogenesis in eukaryotes 1/116 109/8135 0.7932 0.835 0.7917 POP1 1 KEGG hsa05205 Proteoglycans in cancer 2/116 205/8135 0.7951 0.835 0.7917 ROCK1/AKT3 2 KEGG hsa04668 TNF signaling pathway 1/116 112/8135 0.802 0.8391 0.7955 AKT3 1 KEGG hsa05170 Human immunodeficiency virus 1 infection 2/116 212/8135 0.8103 0.8444 0.8006 IFNA10/AKT3 2 KEGG hsa05206 MicroRNAs in cancer 3/116 310/8135 0.8248 0.8547 0.8103 SHC1/ROCK1/UBE2I 3 KEGG hsa04919 Thyroid hormone signaling pathway 1/116 121/8135 0.8264 0.8547 0.8103 AKT3 1 KEGG hsa00230 Purine metabolism 1/116 128/8135 0.8432 0.8688 0.8237 ADCY8 1 KEGG hsa05171 Coronavirus disease - COVID-19 2/116 232/8135 0.8484 0.8708 0.8256 IFNA10/OAS2 2 KEGG hsa04142 Lysosome 1/116 132/8135 0.8521 0.8713 0.8262 AGA 1 KEGG hsa04390 Hippo signaling pathway 1/116 157/8135 0.8974 0.9123 0.865 DVL1 1 KEGG hsa03010 Ribosome 1/116 158/8135 0.8989 0.9123 0.865 MRPL16 1 KEGG hsa04310 Wnt signaling pathway 1/116 167/8135 0.9114 0.9215 0.8738 DVL1 1 KEGG hsa04360 Axon guidance 1/116 182/8135 0.9289 0.9358 0.8873 ROCK1 1 KEGG hsa05202 Transcriptional misregulation in cancer 1/116 193/8135 0.9395 0.943 0.8941 SP1 1 KEGG hsa04144 Endocytosis 1/116 251/8135 0.9743 0.9743 0.9238 HSPA2 1