ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04740 Olfactory transduction 21/139 440/8135 1.626e-05 0.004228 0.004228 OR2A42/OR7G2/OR4F17/OR2G2/OR52B6/OR2T34/OR4X2/OR11L1/OR8U1/OR10K2/GUCY2D/OR52N4/OR10AG1/OR1A1/OR2A12/OR1L6/CALM3/OR5H2/OR5AK2/OR1B1/OR5K4 21 KEGG hsa04912 GnRH signaling pathway 6/139 93/8135 0.005043 0.6557 0.6557 MAP2K1/MAPK13/MAP3K3/ADCY2/CALM3/PRKCD 6 KEGG hsa04022 cGMP-PKG signaling pathway 8/139 167/8135 0.007716 0.6682 0.6682 MAP2K1/NPPC/MYL9/ADORA1/ADCY2/IRS1/CALM3/ATP2B2 8 KEGG hsa04140 Autophagy - animal 7/139 141/8135 0.01035 0.6682 0.6682 ATG14/MAP2K1/MTMR14/IRS1/RPTOR/BCL2L1/PRKCD 7 KEGG hsa04071 Sphingolipid signaling pathway 6/139 119/8135 0.01604 0.6682 0.6682 MAP2K1/SPTLC2/MAPK13/ADORA1/SGMS1/RAC2 6 KEGG hsa04722 Neurotrophin signaling pathway 6/139 119/8135 0.01604 0.6682 0.6682 MAP2K1/MAPK13/MAP3K3/IRS1/CALM3/PRKCD 6 KEGG hsa04370 VEGF signaling pathway 4/139 59/8135 0.01799 0.6682 0.6682 MAP2K1/MAPK13/MAPKAPK3/RAC2 4 KEGG hsa04270 Vascular smooth muscle contraction 6/139 134/8135 0.02703 0.7734 0.7734 MAP2K1/NPPC/MYL9/ADCY2/CALM3/PRKCD 6 KEGG hsa04915 Estrogen signaling pathway 6/139 138/8135 0.03063 0.7734 0.7734 MAP2K1/ESR1/ADCY2/CALM3/PRKCD/KRT12 6 KEGG hsa04024 cAMP signaling pathway 8/139 221/8135 0.03538 0.7734 0.7734 MAP2K1/MYL9/FXYD1/ADORA1/ADCY2/CALM3/ATP2B2/RAC2 8 KEGG hsa03040 Spliceosome 6/139 147/8135 0.03986 0.7734 0.7734 SRSF3/SF3A1/XAB2/SF3B3/PRPF19/ISY1 6 KEGG hsa05212 Pancreatic cancer 4/139 76/8135 0.04071 0.7734 0.7734 MAP2K1/CDK6/BCL2L1/RAC2 4 KEGG hsa04932 Non-alcoholic fatty liver disease 6/139 155/8135 0.04941 0.7734 0.7734 MAPK13/NDUFA4L2/NDUFA13/ADIPOR1/SDHB/IRS1 6 KEGG hsa04146 Peroxisome 4/139 82/8135 0.05138 0.7734 0.7734 PRDX5/CRAT/PEX14/MVK 4 KEGG hsa04935 Growth hormone synthesis, secretion and action 5/139 119/8135 0.05279 0.7734 0.7734 MAP2K1/MAPK13/CSH1/ADCY2/IRS1 5 KEGG hsa05415 Diabetic cardiomyopathy 7/139 203/8135 0.05886 0.7734 0.7734 MAPK13/NDUFA4L2/NDUFA13/SDHB/IRS1/RAC2/PRKCD 7 KEGG hsa05131 Shigellosis 8/139 247/8135 0.06074 0.7734 0.7734 ATG14/CYTH2/MAPK13/ARHGEF2/MYL9/RPTOR/BCL2L1/PRKCD 8 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2/139 24/8135 0.06263 0.7734 0.7734 B4GALT7/EXT1 2 KEGG hsa04211 Longevity regulating pathway 4/139 89/8135 0.06559 0.7734 0.7734 ADIPOR1/ADCY2/IRS1/RPTOR 4 KEGG hsa04923 Regulation of lipolysis in adipocytes 3/139 56/8135 0.07031 0.7734 0.7734 ADORA1/ADCY2/IRS1 3 KEGG hsa04068 FoxO signaling pathway 5/139 131/8135 0.07342 0.7734 0.7734 MAP2K1/MAPK13/HOMER2/FBXO25/IRS1 5 KEGG hsa04114 Oocyte meiosis 5/139 131/8135 0.07342 0.7734 0.7734 MAP2K1/MAPK13/ADCY2/SPDYE1/CALM3 5 KEGG hsa01522 Endocrine resistance 4/139 98/8135 0.08654 0.7734 0.7734 MAP2K1/ESR1/MAPK13/ADCY2 4 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 4/139 98/8135 0.08654 0.7734 0.7734 MAPK13/ADCY2/CALM3/PRKCD 4 KEGG hsa04925 Aldosterone synthesis and secretion 4/139 98/8135 0.08654 0.7734 0.7734 HSD3B2/ADCY2/CALM3/ATP2B2 4 KEGG hsa04744 Phototransduction 2/139 29/8135 0.08723 0.7734 0.7734 GUCY2D/CALM3 2 KEGG hsa04640 Hematopoietic cell lineage 4/139 99/8135 0.08905 0.7734 0.7734 IL3RA/CSF1R/IL11/FCER2 4 KEGG hsa04213 Longevity regulating pathway - multiple species 3/139 62/8135 0.08924 0.7734 0.7734 ADCY2/IRS1/RPTOR 3 KEGG hsa05418 Fluid shear stress and atherosclerosis 5/139 139/8135 0.08929 0.7734 0.7734 NPPC/MAPK13/ARHGEF2/CALM3/RAC2 5 KEGG hsa00020 Citrate cycle (TCA cycle) 2/139 30/8135 0.09245 0.7734 0.7734 DLST/SDHB 2 KEGG hsa04914 Progesterone-mediated oocyte maturation 4/139 102/8135 0.09678 0.7734 0.7734 MAP2K1/MAPK13/ADCY2/SPDYE1 4 KEGG hsa00052 Galactose metabolism 2/139 31/8135 0.09776 0.7734 0.7734 PFKL/AKR1B1 2 KEGG hsa05221 Acute myeloid leukemia 3/139 67/8135 0.1065 0.7734 0.7734 MAP2K1/CSF1R/PIM2 3 KEGG hsa00051 Fructose and mannose metabolism 2/139 33/8135 0.1086 0.7734 0.7734 PFKL/AKR1B1 2 KEGG hsa03410 Base excision repair 2/139 33/8135 0.1086 0.7734 0.7734 POLE3/POLB 2 KEGG hsa04130 SNARE interactions in vesicular transport 2/139 33/8135 0.1086 0.7734 0.7734 GOSR1/VAMP1 2 KEGG hsa04664 Fc epsilon RI signaling pathway 3/139 68/8135 0.1101 0.7734 0.7734 MAP2K1/MAPK13/RAC2 3 KEGG hsa04917 Prolactin signaling pathway 3/139 70/8135 0.1174 0.7735 0.7735 MAP2K1/ESR1/MAPK13 3 KEGG hsa05223 Non-small cell lung cancer 3/139 72/8135 0.1249 0.7735 0.7735 MAP2K1/FHIT/CDK6 3 KEGG hsa00350 Tyrosine metabolism 2/139 36/8135 0.1255 0.7735 0.7735 GOT1/GSTZ1 2 KEGG hsa00512 Mucin type O-glycan biosynthesis 2/139 36/8135 0.1255 0.7735 0.7735 GALNT2/ST3GAL1 2 KEGG hsa04150 mTOR signaling pathway 5/139 156/8135 0.1284 0.7735 0.7735 MAP2K1/WDR24/IRS1/ATP6V1E1/RPTOR 5 KEGG hsa01200 Carbon metabolism 4/139 115/8135 0.1337 0.7735 0.7735 GOT1/DLST/SDHB/PFKL 4 KEGG hsa05214 Glioma 3/139 75/8135 0.1364 0.7735 0.7735 MAP2K1/CDK6/CALM3 3 KEGG hsa05220 Chronic myeloid leukemia 3/139 76/8135 0.1404 0.7735 0.7735 MAP2K1/CDK6/BCL2L1 3 KEGG hsa04152 AMPK signaling pathway 4/139 120/8135 0.1492 0.7735 0.7735 ADIPOR1/PFKL/IRS1/RPTOR 4 KEGG hsa04015 Rap1 signaling pathway 6/139 210/8135 0.15 0.7735 0.7735 MAP2K1/MAPK13/CSF1R/ADCY2/CALM3/RAC2 6 KEGG hsa05170 Human immunodeficiency virus 1 infection 6/139 212/8135 0.1547 0.7735 0.7735 MAP2K1/MAPK13/CALM3/BCL2L1/RAC2/TRIM5 6 KEGG hsa04975 Fat digestion and absorption 2/139 43/8135 0.1669 0.7735 0.7735 SLC27A4/AGPAT1 2 KEGG hsa05014 Amyotrophic lateral sclerosis 9/139 364/8135 0.1699 0.7735 0.7735 ATG14/RAE1/SRSF3/MAPK13/NDUFA4L2/NDUFA13/SDHB/PSMD6/BCL2L1 9 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 6/139 223/8135 0.1819 0.7735 0.7735 MAP2K1/MAPK13/NDUFA4L2/NDUFA13/SDHB/PRKCD 6 KEGG hsa04930 Type II diabetes mellitus 2/139 46/8135 0.1853 0.7735 0.7735 IRS1/PRKCD 2 KEGG hsa05020 Prion disease 7/139 273/8135 0.1859 0.7735 0.7735 MAPK13/NDUFA4L2/NDUFA13/SDHB/PSMD6/RAC2/PRKCD 7 KEGG hsa05163 Human cytomegalovirus infection 6/139 225/8135 0.1871 0.7735 0.7735 MAP2K1/MAPK13/CDK6/ADCY2/CALM3/RAC2 6 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 3/139 89/8135 0.1946 0.7735 0.7735 MAP2K1/MAPK13/MAP3K3 3 KEGG hsa00190 Oxidative phosphorylation 4/139 134/8135 0.1961 0.7735 0.7735 NDUFA4L2/NDUFA13/SDHB/ATP6V1E1 4 KEGG hsa04714 Thermogenesis 6/139 232/8135 0.2055 0.7735 0.7735 MAPK13/NDUFA4L2/NDUFA13/SDHB/ADCY2/RPTOR 6 KEGG hsa04910 Insulin signaling pathway 4/139 137/8135 0.2066 0.7735 0.7735 MAP2K1/IRS1/CALM3/RPTOR 4 KEGG hsa05222 Small cell lung cancer 3/139 92/8135 0.2078 0.7735 0.7735 FHIT/CDK6/BCL2L1 3 KEGG hsa04970 Salivary secretion 3/139 93/8135 0.2123 0.7735 0.7735 ADCY2/CALM3/ATP2B2 3 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/139 14/8135 0.2145 0.7735 0.7735 ST3GAL1 1 KEGG hsa04913 Ovarian steroidogenesis 2/139 51/8135 0.2165 0.7735 0.7735 HSD3B2/ADCY2 2 KEGG hsa00600 Sphingolipid metabolism 2/139 52/8135 0.2228 0.7735 0.7735 SPTLC2/SGMS1 2 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/139 15/8135 0.228 0.7735 0.7735 ST3GAL1 1 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 1/139 15/8135 0.228 0.7735 0.7735 ST3GAL1 1 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/139 53/8135 0.2291 0.7735 0.7735 ESR1/ATP2B2 2 KEGG hsa04070 Phosphatidylinositol signaling system 3/139 97/8135 0.2302 0.7735 0.7735 ITPKC/MTMR14/CALM3 3 KEGG hsa04666 Fc gamma R-mediated phagocytosis 3/139 97/8135 0.2302 0.7735 0.7735 MAP2K1/RAC2/PRKCD 3 KEGG hsa04062 Chemokine signaling pathway 5/139 192/8135 0.2311 0.7735 0.7735 MAP2K1/PF4/ADCY2/RAC2/PRKCD 5 KEGG hsa05202 Transcriptional misregulation in cancer 5/139 193/8135 0.2343 0.7735 0.7735 LYL1/CSF1R/ETV1/MEIS1/BCL2L1 5 KEGG hsa03460 Fanconi anemia pathway 2/139 54/8135 0.2355 0.7735 0.7735 WDR48/EME1 2 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 5/139 194/8135 0.2374 0.7735 0.7735 ATG14/MAP2K1/MAPK13/CDK6/CALM3 5 KEGG hsa00360 Phenylalanine metabolism 1/139 16/8135 0.2412 0.7735 0.7735 GOT1 1 KEGG hsa04072 Phospholipase D signaling pathway 4/139 148/8135 0.2467 0.7735 0.7735 MAP2K1/CYTH2/AGPAT1/ADCY2 4 KEGG hsa04723 Retrograde endocannabinoid signaling 4/139 148/8135 0.2467 0.7735 0.7735 MAPK13/NDUFA4L2/NDUFA13/ADCY2 4 KEGG hsa04916 Melanogenesis 3/139 101/8135 0.2485 0.7735 0.7735 MAP2K1/ADCY2/CALM3 3 KEGG hsa00120 Primary bile acid biosynthesis 1/139 17/8135 0.2542 0.7735 0.7735 CYP46A1 1 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 4/139 150/8135 0.2542 0.7735 0.7735 MAPK13/ADCY2/CALM3/ATP2B2 4 KEGG hsa04151 PI3K-Akt signaling pathway 8/139 354/8135 0.2585 0.7735 0.7735 MAP2K1/IL3RA/CSF1R/CSH1/CDK6/IRS1/RPTOR/BCL2L1 8 KEGG hsa00240 Pyrimidine metabolism 2/139 58/8135 0.2609 0.7735 0.7735 UPB1/TK2 2 KEGG hsa04625 C-type lectin receptor signaling pathway 3/139 104/8135 0.2623 0.7735 0.7735 MAPK13/CALM3/PRKCD 3 KEGG hsa05169 Epstein-Barr virus infection 5/139 202/8135 0.2632 0.7735 0.7735 ISG15/MAPK13/CDK6/PSMD6/FCER2 5 KEGG hsa04921 Oxytocin signaling pathway 4/139 154/8135 0.2693 0.7735 0.7735 MAP2K1/MYL9/ADCY2/CALM3 4 KEGG hsa04934 Cushing syndrome 4/139 155/8135 0.2731 0.7735 0.7735 MAP2K1/HSD3B2/CDK6/ADCY2 4 KEGG hsa04922 Glucagon signaling pathway 3/139 107/8135 0.2762 0.7735 0.7735 PFKL/ADCY2/CALM3 3 KEGG hsa04218 Cellular senescence 4/139 156/8135 0.2769 0.7735 0.7735 MAP2K1/MAPK13/CDK6/CALM3 4 KEGG hsa01210 2-Oxocarboxylic acid metabolism 1/139 19/8135 0.2795 0.7735 0.7735 GOT1 1 KEGG hsa00140 Steroid hormone biosynthesis 2/139 61/8135 0.28 0.7735 0.7735 HSD11B1L/HSD3B2 2 KEGG hsa00561 Glycerolipid metabolism 2/139 61/8135 0.28 0.7735 0.7735 AGPAT1/AKR1B1 2 KEGG hsa04931 Insulin resistance 3/139 108/8135 0.2809 0.7735 0.7735 SLC27A4/IRS1/PRKCD 3 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/139 20/8135 0.2918 0.7735 0.7735 B4GALT7 1 KEGG hsa03250 Viral life cycle - HIV-1 2/139 63/8135 0.2927 0.7735 0.7735 VPS4B/TRIM5 2 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 10/139 476/8135 0.2956 0.7735 0.7735 ATG14/MAP2K1/MAPK13/NDUFA4L2/NDUFA13/IFT57/SDHB/PSMD6/CALM3/BCL2L1 10 KEGG hsa04630 JAK-STAT signaling pathway 4/139 162/8135 0.2999 0.7735 0.7735 IL3RA/CSH1/IL11/BCL2L1 4 KEGG hsa05012 Parkinson disease 6/139 266/8135 0.3027 0.7735 0.7735 NDUFA4L2/NDUFA13/SDHB/PSMD6/CALM3/BCL2L1 6 KEGG hsa00770 Pantothenate and CoA biosynthesis 1/139 21/8135 0.304 0.7735 0.7735 UPB1 1 KEGG hsa04927 Cortisol synthesis and secretion 2/139 65/8135 0.3053 0.7735 0.7735 HSD3B2/ADCY2 2 KEGG hsa04670 Leukocyte transendothelial migration 3/139 114/8135 0.309 0.7735 0.7735 MAPK13/MYL9/RAC2 3 KEGG hsa00220 Arginine biosynthesis 1/139 22/8135 0.3159 0.7735 0.7735 GOT1 1 KEGG hsa00900 Terpenoid backbone biosynthesis 1/139 22/8135 0.3159 0.7735 0.7735 MVK 1 KEGG hsa04720 Long-term potentiation 2/139 67/8135 0.318 0.7735 0.7735 MAP2K1/CALM3 2 KEGG hsa05166 Human T-cell leukemia virus 1 infection 5/139 222/8135 0.3299 0.7735 0.7735 MAP2K1/MAP3K3/ADCY2/BCL2L1/POLB 5 KEGG hsa04920 Adipocytokine signaling pathway 2/139 69/8135 0.3306 0.7735 0.7735 ADIPOR1/IRS1 2 KEGG hsa04924 Renin secretion 2/139 69/8135 0.3306 0.7735 0.7735 ADORA1/CALM3 2 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 2/139 69/8135 0.3306 0.7735 0.7735 HSD11B1L/SULT1A2 2 KEGG hsa05010 Alzheimer disease 8/139 384/8135 0.334 0.7735 0.7735 ATG14/MAP2K1/NDUFA4L2/NDUFA13/SDHB/PSMD6/IRS1/CALM3 8 KEGG hsa04622 RIG-I-like receptor signaling pathway 2/139 70/8135 0.3368 0.7735 0.7735 ISG15/MAPK13 2 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 2/139 70/8135 0.3368 0.7735 0.7735 MAPK13/ATP6V1E1 2 KEGG hsa05230 Central carbon metabolism in cancer 2/139 70/8135 0.3368 0.7735 0.7735 MAP2K1/PFKL 2 KEGG hsa04977 Vitamin digestion and absorption 1/139 24/8135 0.3391 0.7735 0.7735 SLC52A3 1 KEGG hsa04919 Thyroid hormone signaling pathway 3/139 121/8135 0.3418 0.7735 0.7735 MAP2K1/ESR1/PFKL 3 KEGG hsa05218 Melanoma 2/139 72/8135 0.3493 0.7735 0.7735 MAP2K1/CDK6 2 KEGG hsa00562 Inositol phosphate metabolism 2/139 73/8135 0.3555 0.7735 0.7735 ITPKC/MTMR14 2 KEGG hsa04115 p53 signaling pathway 2/139 73/8135 0.3555 0.7735 0.7735 CDK6/BCL2L1 2 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/139 26/8135 0.3616 0.7735 0.7735 DPM2 1 KEGG hsa00790 Folate biosynthesis 1/139 26/8135 0.3616 0.7735 0.7735 AKR1B1 1 KEGG hsa04014 Ras signaling pathway 5/139 232/8135 0.3639 0.7735 0.7735 MAP2K1/CSF1R/CALM3/BCL2L1/RAC2 5 KEGG hsa01230 Biosynthesis of amino acids 2/139 75/8135 0.3679 0.7735 0.7735 GOT1/PFKL 2 KEGG hsa04966 Collecting duct acid secretion 1/139 27/8135 0.3725 0.7735 0.7735 ATP6V1E1 1 KEGG hsa04971 Gastric acid secretion 2/139 76/8135 0.3741 0.7735 0.7735 ADCY2/CALM3 2 KEGG hsa05133 Pertussis 2/139 76/8135 0.3741 0.7735 0.7735 MAPK13/CALM3 2 KEGG hsa00230 Purine metabolism 3/139 128/8135 0.3746 0.7735 0.7735 FHIT/GUCY2D/ADCY2 3 KEGG hsa04380 Osteoclast differentiation 3/139 128/8135 0.3746 0.7735 0.7735 MAP2K1/MAPK13/CSF1R 3 KEGG hsa04360 Axon guidance 4/139 182/8135 0.3778 0.7735 0.7735 MYL9/SEMA3B/SEMA4G/RAC2 4 KEGG hsa04926 Relaxin signaling pathway 3/139 129/8135 0.3793 0.7735 0.7735 MAP2K1/MAPK13/ADCY2 3 KEGG hsa04010 MAPK signaling pathway 6/139 294/8135 0.3882 0.7735 0.7735 MAP2K1/MAPK13/CSF1R/MAPKAPK3/MAP3K3/RAC2 6 KEGG hsa04060 Cytokine-cytokine receptor interaction 6/139 295/8135 0.3913 0.7735 0.7735 IL3RA/TNFSF4/CSF1R/PF4/CSH1/IL11 6 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 2/139 79/8135 0.3924 0.7735 0.7735 MAP2K1/BCL2L1 2 KEGG hsa03018 RNA degradation 2/139 79/8135 0.3924 0.7735 0.7735 CNOT2/PFKL 2 KEGG hsa04392 Hippo signaling pathway - multiple species 1/139 29/8135 0.3939 0.7735 0.7735 LATS1 1 KEGG hsa00983 Drug metabolism - other enzymes 2/139 80/8135 0.3984 0.7735 0.7735 UPB1/TK2 2 KEGG hsa00030 Pentose phosphate pathway 1/139 30/8135 0.4043 0.7735 0.7735 PFKL 1 KEGG hsa04662 B cell receptor signaling pathway 2/139 82/8135 0.4104 0.7735 0.7735 MAP2K1/RAC2 2 KEGG hsa04210 Apoptosis 3/139 136/8135 0.4117 0.7735 0.7735 MAP2K1/IL3RA/BCL2L1 3 KEGG hsa00410 beta-Alanine metabolism 1/139 31/8135 0.4145 0.7735 0.7735 UPB1 1 KEGG hsa04710 Circadian rhythm 1/139 31/8135 0.4145 0.7735 0.7735 CRY1 1 KEGG hsa05135 Yersinia infection 3/139 137/8135 0.4163 0.7735 0.7735 MAP2K1/MAPK13/RAC2 3 KEGG hsa05132 Salmonella infection 5/139 249/8135 0.4219 0.7735 0.7735 MAP2K1/CYTH2/MAPK13/CYFIP1/MYL9 5 KEGG hsa04136 Autophagy - other 1/139 32/8135 0.4245 0.7735 0.7735 RPTOR 1 KEGG hsa04215 Apoptosis - multiple species 1/139 32/8135 0.4245 0.7735 0.7735 BCL2L1 1 KEGG hsa05016 Huntington disease 6/139 306/8135 0.4251 0.7735 0.7735 ATG14/NDUFA4L2/NDUFA13/IFT57/SDHB/PSMD6 6 KEGG hsa04371 Apelin signaling pathway 3/139 139/8135 0.4254 0.7735 0.7735 MAP2K1/ADCY2/CALM3 3 KEGG hsa05162 Measles 3/139 139/8135 0.4254 0.7735 0.7735 EIF2AK1/CDK6/BCL2L1 3 KEGG hsa05210 Colorectal cancer 2/139 86/8135 0.4341 0.7778 0.7778 MAP2K1/RAC2 2 KEGG hsa05130 Pathogenic Escherichia coli infection 4/139 197/8135 0.4358 0.7778 0.7778 CYTH2/MAPK13/ARHGEF2/CYFIP1 4 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 3/139 143/8135 0.4436 0.7778 0.7778 MAP2K1/MAPK13/MEIS1 3 KEGG hsa00040 Pentose and glucuronate interconversions 1/139 34/8135 0.4441 0.7778 0.7778 AKR1B1 1 KEGG hsa03020 RNA polymerase 1/139 34/8135 0.4441 0.7778 0.7778 ZNRD1 1 KEGG hsa04540 Gap junction 2/139 88/8135 0.4457 0.7778 0.7778 MAP2K1/ADCY2 2 KEGG hsa05224 Breast cancer 3/139 147/8135 0.4615 0.7904 0.7904 MAP2K1/ESR1/CDK6 3 KEGG hsa05032 Morphine addiction 2/139 91/8135 0.4629 0.7904 0.7904 ADORA1/ADCY2 2 KEGG hsa03030 DNA replication 1/139 36/8135 0.463 0.7904 0.7904 POLE3 1 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 1/139 37/8135 0.4722 0.7904 0.7904 GOT1 1 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 1/139 37/8135 0.4722 0.7904 0.7904 IRS1 1 KEGG hsa05216 Thyroid cancer 1/139 37/8135 0.4722 0.7904 0.7904 MAP2K1 1 KEGG hsa05323 Rheumatoid arthritis 2/139 93/8135 0.4743 0.7904 0.7904 IL11/ATP6V1E1 2 KEGG hsa04657 IL-17 signaling pathway 2/139 94/8135 0.4798 0.7947 0.7947 MAPK13/MAPK15 2 KEGG hsa04713 Circadian entrainment 2/139 97/8135 0.4964 0.8034 0.8034 ADCY2/CALM3 2 KEGG hsa00564 Glycerophospholipid metabolism 2/139 98/8135 0.5019 0.8034 0.8034 AGPAT1/LCAT 2 KEGG hsa05231 Choline metabolism in cancer 2/139 98/8135 0.5019 0.8034 0.8034 MAP2K1/RAC2 2 KEGG hsa05160 Hepatitis C 3/139 157/8135 0.5052 0.8034 0.8034 EIF2AK1/MAP2K1/CDK6 3 KEGG hsa03440 Homologous recombination 1/139 41/8135 0.5076 0.8034 0.8034 EME1 1 KEGG hsa05219 Bladder cancer 1/139 41/8135 0.5076 0.8034 0.8034 MAP2K1 1 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 2/139 100/8135 0.5127 0.8034 0.8034 CSF1R/PF4 2 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 2/139 100/8135 0.5127 0.8034 0.8034 MAPK13/PRKCD 2 KEGG hsa04810 Regulation of actin cytoskeleton 4/139 218/8135 0.5143 0.8034 0.8034 MAP2K1/CYFIP1/MYL9/RAC2 4 KEGG hsa00380 Tryptophan metabolism 1/139 42/8135 0.516 0.8034 0.8034 DLST 1 KEGG hsa04972 Pancreatic secretion 2/139 102/8135 0.5233 0.806 0.806 ADCY2/ATP2B2 2 KEGG hsa04620 Toll-like receptor signaling pathway 2/139 104/8135 0.5338 0.806 0.806 MAP2K1/MAPK13 2 KEGG hsa04660 T cell receptor signaling pathway 2/139 104/8135 0.5338 0.806 0.806 MAP2K1/MAPK13 2 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 2/139 106/8135 0.5441 0.806 0.806 MAP2K1/ADCY2 2 KEGG hsa03050 Proteasome 1/139 46/8135 0.5484 0.806 0.806 PSMD6 1 KEGG hsa05225 Hepatocellular carcinoma 3/139 168/8135 0.551 0.806 0.806 MAP2K1/CDK6/BCL2L1 3 KEGG hsa03013 Nucleocytoplasmic transport 2/139 108/8135 0.5543 0.806 0.806 RAE1/IPO9 2 KEGG hsa00514 Other types of O-glycan biosynthesis 1/139 47/8135 0.5562 0.806 0.806 GALNT2 1 KEGG hsa03420 Nucleotide excision repair 1/139 47/8135 0.5562 0.806 0.806 POLE3 1 KEGG hsa03008 Ribosome biogenesis in eukaryotes 2/139 109/8135 0.5593 0.806 0.806 BMS1/POP1 2 KEGG hsa04066 HIF-1 signaling pathway 2/139 109/8135 0.5593 0.806 0.806 MAP2K1/PFKL 2 KEGG hsa05164 Influenza A 3/139 171/8135 0.5631 0.806 0.806 RAE1/MAP2K1/CDK6 3 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 1/139 49/8135 0.5713 0.806 0.806 CYB5R4 1 KEGG hsa04668 TNF signaling pathway 2/139 112/8135 0.5741 0.806 0.806 MAP2K1/MAPK13 2 KEGG hsa05145 Toxoplasmosis 2/139 112/8135 0.5741 0.806 0.806 MAPK13/BCL2L1 2 KEGG hsa00510 N-Glycan biosynthesis 1/139 50/8135 0.5787 0.806 0.806 DPM2 1 KEGG hsa04979 Cholesterol metabolism 1/139 50/8135 0.5787 0.806 0.806 LCAT 1 KEGG hsa05110 Vibrio cholerae infection 1/139 50/8135 0.5787 0.806 0.806 ATP6V1E1 1 KEGG hsa04725 Cholinergic synapse 2/139 113/8135 0.579 0.806 0.806 MAP2K1/ADCY2 2 KEGG hsa04724 Glutamatergic synapse 2/139 114/8135 0.5838 0.806 0.806 HOMER2/ADCY2 2 KEGG hsa00270 Cysteine and methionine metabolism 1/139 51/8135 0.5859 0.806 0.806 GOT1 1 KEGG hsa00330 Arginine and proline metabolism 1/139 51/8135 0.5859 0.806 0.806 GOT1 1 KEGG hsa04020 Calcium signaling pathway 4/139 240/8135 0.5909 0.8086 0.8086 ITPKC/ADCY2/CALM3/ATP2B2 4 KEGG hsa04621 NOD-like receptor signaling pathway 3/139 184/8135 0.6131 0.8347 0.8347 MAPK13/BCL2L1/PRKCD 3 KEGG hsa04340 Hedgehog signaling pathway 1/139 56/8135 0.6203 0.84 0.84 SUFU 1 KEGG hsa05134 Legionellosis 1/139 57/8135 0.6269 0.8422 0.8422 RAB1B 1 KEGG hsa04611 Platelet activation 2/139 124/8135 0.6298 0.8422 0.8422 MAPK13/ADCY2 2 KEGG hsa05213 Endometrial cancer 1/139 58/8135 0.6333 0.8422 0.8422 MAP2K1 1 KEGG hsa04613 Neutrophil extracellular trap formation 3/139 190/8135 0.6349 0.8422 0.8422 MAP2K1/MAPK13/RAC2 3 KEGG hsa04730 Long-term depression 1/139 60/8135 0.6458 0.8437 0.8437 MAP2K1 1 KEGG hsa04978 Mineral absorption 1/139 60/8135 0.6458 0.8437 0.8437 ATP2B2 1 KEGG hsa05416 Viral myocarditis 1/139 60/8135 0.6458 0.8437 0.8437 RAC2 1 KEGG hsa04650 Natural killer cell mediated cytotoxicity 2/139 131/8135 0.6596 0.846 0.846 MAP2K1/RAC2 2 KEGG hsa04142 Lysosome 2/139 132/8135 0.6637 0.846 0.846 SUMF1/AP4B1 2 KEGG hsa04728 Dopaminergic synapse 2/139 132/8135 0.6637 0.846 0.846 MAPK13/CALM3 2 KEGG hsa00310 Lysine degradation 1/139 63/8135 0.6638 0.846 0.846 DLST 1 KEGG hsa05217 Basal cell carcinoma 1/139 63/8135 0.6638 0.846 0.846 SUFU 1 KEGG hsa04929 GnRH secretion 1/139 64/8135 0.6696 0.8489 0.8489 MAP2K1 1 KEGG hsa04510 Focal adhesion 3/139 201/8135 0.6726 0.8489 0.8489 MAP2K1/MYL9/RAC2 3 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/139 66/8135 0.6808 0.8515 0.8515 TARS2 1 KEGG hsa05205 Proteoglycans in cancer 3/139 205/8135 0.6856 0.8515 0.8515 MAP2K1/ESR1/MAPK13 3 KEGG hsa00010 Glycolysis / Gluconeogenesis 1/139 67/8135 0.6863 0.8515 0.8515 PFKL 1 KEGG hsa05031 Amphetamine addiction 1/139 69/8135 0.6971 0.8515 0.8515 CALM3 1 KEGG hsa05211 Renal cell carcinoma 1/139 69/8135 0.6971 0.8515 0.8515 MAP2K1 1 KEGG hsa04120 Ubiquitin mediated proteolysis 2/139 142/8135 0.7025 0.8515 0.8515 PRPF19/UBOX5 2 KEGG hsa04936 Alcoholic liver disease 2/139 142/8135 0.7025 0.8515 0.8515 MAPK13/ADIPOR1 2 KEGG hsa05017 Spinocerebellar ataxia 2/139 143/8135 0.7062 0.8515 0.8515 ATG14/PSMD6 2 KEGG hsa05207 Chemical carcinogenesis - receptor activation 3/139 212/8135 0.7074 0.8515 0.8515 MAP2K1/ESR1/ADCY2 3 KEGG hsa04520 Adherens junction 1/139 71/8135 0.7074 0.8515 0.8515 RAC2 1 KEGG hsa04137 Mitophagy - animal 1/139 72/8135 0.7125 0.8517 0.8517 BCL2L1 1 KEGG hsa05417 Lipid and atherosclerosis 3/139 215/8135 0.7164 0.8517 0.8517 MAPK13/CALM3/BCL2L1 3 KEGG hsa01524 Platinum drug resistance 1/139 73/8135 0.7174 0.8517 0.8517 BCL2L1 1 KEGG hsa03320 PPAR signaling pathway 1/139 75/8135 0.7271 0.8554 0.8554 SLC27A4 1 KEGG hsa04918 Thyroid hormone synthesis 1/139 75/8135 0.7271 0.8554 0.8554 ADCY2 1 KEGG hsa05140 Leishmaniasis 1/139 77/8135 0.7364 0.86 0.86 MAPK13 1 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 1/139 78/8135 0.741 0.86 0.86 HSD11B1L 1 KEGG hsa04721 Synaptic vesicle cycle 1/139 78/8135 0.741 0.86 0.86 ATP6V1E1 1 KEGG hsa05168 Herpes simplex virus 1 infection 7/139 495/8135 0.7499 0.8665 0.8665 HCFC1/EIF2AK1/ZNF155/SRSF3/ZFP14/ZFP82/BCL2L1 7 KEGG hsa05161 Hepatitis B 2/139 162/8135 0.7691 0.8732 0.8732 MAP2K1/MAPK13 2 KEGG hsa01232 Nucleotide metabolism 1/139 85/8135 0.7707 0.8732 0.8732 TK2 1 KEGG hsa04012 ErbB signaling pathway 1/139 85/8135 0.7707 0.8732 0.8732 MAP2K1 1 KEGG hsa04742 Taste transduction 1/139 86/8135 0.7746 0.8732 0.8732 TAS2R50 1 KEGG hsa04911 Insulin secretion 1/139 86/8135 0.7746 0.8732 0.8732 ADCY2 1 KEGG hsa04260 Cardiac muscle contraction 1/139 87/8135 0.7785 0.8732 0.8732 SLC9A6 1 KEGG hsa05206 MicroRNAs in cancer 4/139 310/8135 0.7821 0.8732 0.8732 MAP2K1/CDK6/IRS1/RPTOR 4 KEGG hsa04727 GABAergic synapse 1/139 89/8135 0.7861 0.8732 0.8732 ADCY2 1 KEGG hsa04976 Bile secretion 1/139 89/8135 0.7861 0.8732 0.8732 ADCY2 1 KEGG hsa04530 Tight junction 2/139 169/8135 0.7892 0.8732 0.8732 ARHGEF2/MYL9 2 KEGG hsa04141 Protein processing in endoplasmic reticulum 2/139 171/8135 0.7946 0.8744 0.8744 EIF2AK1/SEC31A 2 KEGG hsa04658 Th1 and Th2 cell differentiation 1/139 92/8135 0.797 0.8744 0.8744 MAPK13 1 KEGG hsa05150 Staphylococcus aureus infection 1/139 96/8135 0.8107 0.8781 0.8781 KRT12 1 KEGG hsa05414 Dilated cardiomyopathy 1/139 96/8135 0.8107 0.8781 0.8781 ADCY2 1 KEGG hsa03015 mRNA surveillance pathway 1/139 97/8135 0.814 0.8781 0.8781 PAPOLA 1 KEGG hsa05215 Prostate cancer 1/139 97/8135 0.814 0.8781 0.8781 MAP2K1 1 KEGG hsa05152 Tuberculosis 2/139 180/8135 0.8177 0.8785 0.8785 MAPK13/CALM3 2 KEGG hsa05165 Human papillomavirus infection 4/139 331/8135 0.8235 0.8811 0.8811 MAP2K1/ISG15/CDK6/ATP6V1E1 4 KEGG hsa05142 Chagas disease 1/139 102/8135 0.8295 0.8829 0.8829 MAPK13 1 KEGG hsa05034 Alcoholism 2/139 187/8135 0.8339 0.8829 0.8829 MAP2K1/CALM3 2 KEGG hsa04064 NF-kappa B signaling pathway 1/139 104/8135 0.8353 0.8829 0.8829 BCL2L1 1 KEGG hsa04659 Th17 cell differentiation 1/139 108/8135 0.8465 0.891 0.891 MAPK13 1 KEGG hsa04726 Serotonergic synapse 1/139 115/8135 0.8641 0.9059 0.9059 MAP2K1 1 KEGG hsa05203 Viral carcinogenesis 2/139 204/8135 0.8682 0.9065 0.9065 CDK6/POLB 2 KEGG hsa04110 Cell cycle 1/139 126/8135 0.8879 0.9234 0.9234 CDK6 1 KEGG hsa05171 Coronavirus disease - COVID-19 2/139 232/8135 0.9108 0.9435 0.9435 ISG15/MAPK13 2 KEGG hsa05226 Gastric cancer 1/139 149/8135 0.9251 0.9444 0.9444 MAP2K1 1 KEGG hsa04145 Phagosome 1/139 152/8135 0.929 0.9444 0.9444 ATP6V1E1 1 KEGG hsa01240 Biosynthesis of cofactors 1/139 153/8135 0.9302 0.9444 0.9444 PHOSPHO2 1 KEGG hsa04144 Endocytosis 2/139 251/8135 0.932 0.9444 0.9444 CYTH2/VPS4B 2 KEGG hsa04390 Hippo signaling pathway 1/139 157/8135 0.9349 0.9444 0.9444 LATS1 1 KEGG hsa03010 Ribosome 1/139 158/8135 0.9361 0.9444 0.9444 MRPS5 1 KEGG hsa04217 Necroptosis 1/139 159/8135 0.9372 0.9444 0.9444 VPS4B 1 KEGG hsa04080 Neuroactive ligand-receptor interaction 3/139 353/8135 0.9447 0.9454 0.9454 CSH1/ADORA1/TRH 3 KEGG hsa04310 Wnt signaling pathway 1/139 167/8135 0.9454 0.9454 0.9454 RAC2 1