ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04371	Apelin signaling pathway	27/848	139/8135	0.0009955	0.08682	0.07579	AKT2/KLF2/GNAQ/SPHK2/GNAI2/RPS6KB2/CALM3/SLC8A1/PDE3B/PLCB1/ADCY3/MAPK3/MYLK/AKT1/TGFBR1/MTOR/ITPR2/PRKAA2/GNGT2/MAP1LC3B2/GNB3/HDAC5/SPHK1/GNG2/GNG10/GNG5/GNB2	27
KEGG	hsa05165	Human papillomavirus infection	52/848	331/8135	0.001529	0.08682	0.07579	DVL1/AXIN1/E2F1/AKT2/ITGA4/SCRIB/UBE3A/PIK3R1/MAML3/CREBBP/WNT2B/RPS6KB2/CDK6/THBS3/ISG15/PPP2R5E/LLGL1/EP300/CCNE1/APC2/VWF/TSC2/LLGL2/CHD4/TNXB/NOTCH2/PTGS2/OASL/PPP2R5D/MAPK3/SOS2/AKT1/JAK1/RBL1/MTOR/APC/PDGFRB/MFNG/COL9A1/NOTCH1/ATP6V1E2/PARD6B/PPP2R2B/PKM/DVL2/HLA-G/ATP6V0A2/THBS1/ATP6V0E1/MX1/EIF2AK2/COL4A1	52
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	34/848	194/8135	0.001592	0.08682	0.07579	UBC/E2F1/AKT2/NFATC3/PIK3R1/CREBBP/CDK6/FOS/EP300/JUN/CALM3/E2F2/ATG14/CXCL1/MAP2K7/PPP3CA/PTGS2/MAPK3/AKT1/ZFP36/JAK1/MTOR/ITPR2/MAPK13/GNGT2/MAP1LC3B2/GNB3/HLA-G/UBB/GNG2/EIF2AK2/GNG10/GNG5/GNB2	34
KEGG	hsa03250	Viral life cycle - HIV-1	15/848	63/8135	0.001665	0.08682	0.07579	MAP1A/CDK9/CPSF6/SERINC5/NUP153/CREBBP/EP300/PDCD6IP/BST2/PIN1/CCNT1/CPSF7/MX1/FURIN/ELL	15
KEGG	hsa04910	Insulin signaling pathway	26/848	137/8135	0.001738	0.08682	0.07579	RPTOR/AKT2/G6PC/MKNK2/PIK3R1/PTPN1/SOCS4/RPS6KB2/CBL/CALM3/PDE3B/TSC2/RAPGEF1/CBLB/MAPK3/INPP5A/SOS2/AKT1/MTOR/PPP1R3D/PPP1R3E/PRKAA2/PHKA2/PDPK1/HK2/TRIP10	26
KEGG	hsa05212	Pancreatic cancer	17/848	76/8135	0.001756	0.08682	0.07579	E2F1/AKT2/PIK3R1/RPS6KB2/CDK6/E2F2/MAPK3/AKT1/RALBP1/TGFBR1/JAK1/MTOR/PLD1/RAC2/ARHGEF6/BCL2L1/DDB2	17
KEGG	hsa03015	mRNA surveillance pathway	20/848	97/8135	0.002075	0.08682	0.07579	CPSF1/CPSF6/PCF11/NXF1/PABPN1L/PPP2R5E/PABPC1/MSI2/PABPC4/NXF3/PPP2R5D/UPF2/DDX39B/PNN/PPP2R2B/CASC3/SMG6/CPSF4L/CPSF7/UPF3B	20
KEGG	hsa04520	Adherens junction	16/848	71/8135	0.002186	0.08682	0.07579	FARP2/NLK/WASL/YES1/SSX2IP/PTPN1/IGF1R/CREBBP/EP300/WASF2/BAIAP2/MAPK3/TGFBR1/CTNNA1/RAC2/ACTN4	16
KEGG	hsa04330	Notch signaling pathway	14/848	59/8135	0.002432	0.08682	0.07579	DVL1/MAML3/CREBBP/EP300/NCOR2/NOTCH2/TLE3/TLE1/MFNG/NOTCH1/DTX1/DVL2/ATXN1L/CTBP2	14
KEGG	hsa04140	Autophagy - animal	26/848	141/8135	0.002647	0.08682	0.07579	RPTOR/AKT2/DDIT4/CTSD/ATG16L2/PIK3R1/IGF1R/HMGB1/SMCR8/RPS6KB2/ATG4D/AKT1S1/GABARAPL1/GABARAP/TSC2/ATG14/MLST8/EIF2AK4/MAPK3/AKT1/MTOR/PRKAA2/MAP1LC3B2/PDPK1/BCL2L1/C9orf72	26
KEGG	hsa05220	Chronic myeloid leukemia	16/848	76/8135	0.004508	0.127	0.1108	E2F1/AKT2/ABL1/PIK3R1/GAB2/CDK6/CBL/E2F2/BCR/MAPK3/SOS2/AKT1/TGFBR1/BCL2L1/CTBP2/DDB2	16
KEGG	hsa04071	Sphingolipid signaling pathway	22/848	119/8135	0.005269	0.127	0.1108	AKT2/SPTLC3/CTSD/GNAQ/PIK3R1/GAB2/SPHK2/GNAI2/FCER1G/PPP2R5E/CERS6/PLCB1/PPP2R5D/MAPK3/AKT1/MAPK13/PPP2R2B/PLD1/RAC2/PDPK1/SPHK1/CERS2	22
KEGG	hsa04014	Ras signaling pathway	37/848	232/8135	0.005416	0.127	0.1108	RGL2/RASA4/AKT2/FLT4/ABL1/KSR1/PIK3R1/IGF1R/GAB2/ANGPT1/CALM3/RASA4B/FOXO4/MAPK3/SOS2/AKT1/RALBP1/PLA2G4A/GAB1/PDGFRB/GNGT2/PLD1/RAC2/RASA3/GNB3/PLA2G2C/BCL2L1/RASGRP1/GNG2/RASSF1/RASGRP4/GNG10/GNG5/RASGRP3/GNB2/ARF6/FGF8	37
KEGG	hsa05231	Choline metabolism in cancer	19/848	98/8135	0.005419	0.127	0.1108	AKT2/PIP5K1B/PIK3R1/RPS6KB2/FOS/JUN/TSC2/WASF2/MAPK3/SOS2/PIP5K1C/AKT1/PLA2G4A/MTOR/PDGFRB/PLD1/RAC2/PDPK1/PCYT1B	19
KEGG	hsa05135	Yersinia infection	24/848	137/8135	0.007353	0.1472	0.1285	AKT2/ITGA4/PIP5K1B/WASL/ARPC3/NFATC3/GNAQ/PIK3R1/IRAK1/RPS6KA2/FOS/JUN/WASF2/BAIAP2/MAP2K7/MAPK3/PIP5K1C/AKT1/ARPC2/MAPK13/ARHGEF1/RPS6KA3/RAC2/ARF6	24
KEGG	hsa05225	Hepatocellular carcinoma	28/848	168/8135	0.008028	0.1472	0.1285	DVL1/AXIN1/ARID1B/E2F1/AKT2/GSTA4/PIK3R1/IGF1R/WNT2B/RPS6KB2/CDK6/ARID1A/SMARCC2/GSTM1/APC2/E2F2/MAPK3/SMARCC1/SOS2/AKT1/TGFBR1/MGST3/GAB1/MTOR/APC/DVL2/BCL2L1/DDB2	28
KEGG	hsa05161	Hepatitis B	27/848	162/8135	0.009131	0.1472	0.1285	ATF4/E2F1/AKT2/NFATC3/STAT6/PIK3R1/IRAK1/CREBBP/FOS/EGR3/EP300/JUN/CCNE1/DDX3X/E2F2/DDB1/MAP2K7/MAPK3/SOS2/VDAC3/AKT1/TGFBR1/JAK1/MAPK13/PCNA/DDB2/STAT4	27
KEGG	hsa05224	Breast cancer	25/848	147/8135	0.009209	0.1472	0.1285	DVL1/AXIN1/E2F1/AKT2/FLT4/PIK3R1/IGF1R/NCOA1/WNT2B/RPS6KB2/CDK6/FOS/JUN/APC2/E2F2/NOTCH2/MAPK3/SOS2/AKT1/MTOR/APC/NOTCH1/DVL2/DDB2/FGF8	25
KEGG	hsa04662	B cell receptor signaling pathway	16/848	82/8135	0.009618	0.1472	0.1285	AKT2/LILRB4/MALT1/NFATC3/PIK3R1/FOS/LILRA5/JUN/PPP3CA/MAPK3/SOS2/LILRA1/AKT1/RAC2/CD79B/RASGRP3	16
KEGG	hsa05163	Human cytomegalovirus infection	35/848	225/8135	0.009864	0.1472	0.1285	ATF4/E2F1/AKT2/NFATC3/GNAQ/PIK3R1/GNAI2/RPS6KB2/IL10RB/CDK6/CALM3/TSC2/E2F2/PLCB1/ADCY3/PPP3CA/PTGS2/MAPK3/SOS2/AKT1/JAK1/MTOR/ITPR2/MAPK13/ARHGEF1/CX3CL1/GNGT2/CALR/RAC2/GNB3/HLA-G/GNG2/GNG10/GNG5/GNB2	35
KEGG	hsa04723	Retrograde endocannabinoid signaling	25/848	148/8135	0.01002	0.1472	0.1285	GABRR2/GNAQ/NDUFS7/GNAI2/NAPEPLD/PLCB1/ADCY3/NDUFV1/PTGS2/MAPK3/ITPR2/MAPK13/NDUFA4/NDUFA10/GNGT2/NDUFA7/GNB3/GABRB1/NDUFB7/NDUFA12/NDUFS8/GNG2/GNG10/GNG5/GNB2	25
KEGG	hsa04625	C-type lectin receptor signaling pathway	19/848	104/8135	0.01036	0.1472	0.1285	CLEC4E/AKT2/MALT1/NFATC3/KSR1/PIK3R1/FCER1G/IL23A/EGR3/JUN/CALM3/CBLB/CLEC4D/PPP3CA/PTGS2/MAPK3/AKT1/ITPR2/MAPK13	19
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	18/848	97/8135	0.01057	0.1472	0.1285	AKT2/PIP5K1B/ARPC3/PIK3R1/GAB2/SPHK2/RPS6KB2/WASF2/ASAP1/MAPK3/PIP5K1C/AKT1/PLA2G4A/ARPC2/PLD1/RAC2/SPHK1/ARF6	18
KEGG	hsa04722	Neurotrophin signaling pathway	21/848	119/8135	0.01077	0.1472	0.1285	ATF4/AKT2/ABL1/PIK3R1/ARHGDIB/IRAK1/RPS6KA2/JUN/SH2B1/CALM3/RAPGEF1/MAP2K7/MAPK3/SOS2/AKT1/GAB1/MAPK13/RPS6KA3/MAP3K3/PDPK1/RPS6KA5	21
KEGG	hsa05210	Colorectal cancer	16/848	86/8135	0.01504	0.1891	0.1651	AXIN1/AKT2/PIK3R1/RPS6KB2/FOS/JUN/APC2/MSH6/MAPK3/SOS2/AKT1/TGFBR1/MTOR/APC/RAC2/DDB2	16
KEGG	hsa04530	Tight junction	27/848	169/8135	0.01565	0.1891	0.1651	MYL6B/OCLN/TUBA1C/CLDN6/RAPGEF2/ARPC3/SCRIB/MPP4/TUBA1A/AMOT/MYL12A/CD1D/LLGL1/JUN/MSN/NEDD4/LLGL2/MAP2K7/RAB13/ARPC2/PRKAA2/PARD6B/PPP2R2B/PCNA/ACTN4/EPB41L4B/CLDN10	27
KEGG	hsa04068	FoxO signaling pathway	22/848	131/8135	0.01609	0.1891	0.1651	AKT2/NLK/KLF2/USP7/G6PC/PIK3R1/IGF1R/CREBBP/PRMT1/EP300/CDKN2D/GABARAPL1/GABARAP/PLK2/FOXO4/MAPK3/SOS2/AKT1/TGFBR1/MAPK13/PRKAA2/PDPK1	22
KEGG	hsa01524	Platinum drug resistance	14/848	73/8135	0.0172	0.1891	0.1651	AKT2/GSTA4/PIK3R1/GSTM1/TOP2A/MSH6/MAPK3/AKT1/MGST3/ATP7B/REV3L/PDPK1/BCL2L1/XPA	14
KEGG	hsa04072	Phospholipase D signaling pathway	24/848	148/8135	0.01846	0.1891	0.1651	AKT2/AGPAT1/PIP5K1B/PIK3R1/GAB2/SPHK2/FCER1G/TSC2/PLCB1/ADCY3/MAPK3/SOS2/PIP5K1C/AKT1/PLA2G4A/GAB1/MTOR/PDGFRB/AGPAT2/PLD1/F2R/SPHK1/GRM2/ARF6	24
KEGG	hsa04218	Cellular senescence	25/848	156/8135	0.01884	0.1891	0.1651	E2F1/AKT2/MYBL2/NFATC3/LIN9/PIK3R1/HIPK1/CDK6/CCNE1/CALM3/TSC2/E2F2/PPP3CA/MAPK3/SLC25A5/VDAC3/AKT1/TGFBR1/RBL1/SLC25A6/MTOR/ITPR2/MAPK13/HIPK3/HLA-G	25
KEGG	hsa05170	Human immunodeficiency virus 1 infection	32/848	212/8135	0.01987	0.1891	0.1651	AKT2/NFATC3/GNAQ/PIK3R1/IRAK1/GNAI2/RPS6KB2/FOS/JUN/CALM3/BST2/DDB1/MAP2K7/PPP3CA/MAPK3/AP1M2/AP1G2/AKT1/MTOR/ITPR2/SKP1/MAPK13/GNGT2/CALR/RAC2/GNB3/HLA-G/BCL2L1/GNG2/GNG10/GNG5/GNB2	32
KEGG	hsa05168	Herpes simplex virus 1 infection	66/848	495/8135	0.01988	0.1891	0.1651	ZNF699/ZNF44/ZNF514/ZNF98/AKT2/ZNF764/ZNF768/ZNF439/ZNF417/ZNF558/ZNF792/ZNF543/PIK3R1/IRAK1/NXF1/ZNF587/ZNF577/ZFP14/ZNF570/ZNF304/ZNF415/ZNF689/ZNF316/ZNF547/TSC2/ZNF177/BST2/ZNF684/ZNF708/ZNF440/ZNF12/EIF2AK4/NXF3/ZNF460/ZNF544/ZNF324B/ZNF132/AKT1/JAK1/TLR9/MTOR/POU2F2/ZNF559/ZNF436/OAS2/ZNF714/OAS3/CALR/ZFP30/ZNF256/ZNF222/LTA/ZNF763/HLA-G/ZNF398/BCL2L1/ZNF17/ZNF730/ZNF383/ZNF573/ZNF662/ZNF3/EIF2AK2/ZFP92/ZNF419/ZNF517	66
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/848	89/8135	0.02047	0.1891	0.1651	AKT2/NFATC3/PIK3R1/RPS6KB2/FOS/JUN/PPP3CA/MAPK3/AKT1/JAK1/TLR9/MTOR/MAPK13/MAP3K3/RASGRP1/BATF2	16
KEGG	hsa04010	MAPK signaling pathway	42/848	294/8135	0.02068	0.1891	0.1651	ATF4/AKT2/FLT4/SRF/MAP3K6/NLK/RAPGEF2/MAPK8IP3/NFATC3/MKNK2/IGF1R/IRAK1/ANGPT1/DUSP7/RPS6KA2/JUND/FOS/JUN/MAP3K11/TAOK1/MAP4K4/CACNB4/MAP2K7/PPP3CA/MAPK3/CD14/SOS2/AKT1/TGFBR1/PLA2G4A/PDGFRB/MAPK13/RPS6KA3/MAP3K3/RAC2/RPS6KA4/RASGRP1/CACNA2D1/RPS6KA5/RASGRP4/RASGRP3/FGF8	42
KEGG	hsa03420	Nucleotide excision repair	10/848	47/8135	0.02086	0.1891	0.1651	GTF2H2/RAD23B/ERCC6/LIG1/DDB1/POLD4/CETN2/PCNA/DDB2/XPA	10
KEGG	hsa04664	Fc epsilon RI signaling pathway	13/848	68/8135	0.02176	0.1891	0.1651	AKT2/PIK3R1/GAB2/FCER1G/MAP2K7/MAPK3/SOS2/AKT1/PLA2G4A/MAPK13/RAC2/PDPK1/ALOX5AP	13
KEGG	hsa05215	Prostate cancer	17/848	97/8135	0.02178	0.1891	0.1651	ATF4/E2F1/AKT2/PIK3R1/IGF1R/CREBBP/EP300/CCNE1/E2F2/MAPK3/SOS2/AKT1/MTOR/PDGFRB/ZEB1/PDPK1/ERG	17
KEGG	hsa04668	TNF signaling pathway	19/848	112/8135	0.02191	0.1891	0.1651	ATF4/AKT2/JUNB/PIK3R1/PGAM5/FOS/JUN/CXCL1/MAP2K7/PTGS2/MAPK3/AKT1/MAPK13/CX3CL1/LTA/RPS6KA4/CEBPB/TAB3/RPS6KA5	19
KEGG	hsa05131	Shigellosis	36/848	247/8135	0.02327	0.1957	0.1708	UBC/RPTOR/AKT2/CAST/MALT1/WASL/ARPC3/PIK3R1/RPS6KB2/MYL12A/JUN/AKT1S1/WASF2/PLCB1/ATG14/FOXO4/MAPK3/CD14/AKT1/MTOR/ITPR2/ARPC2/SKP1/MAPK13/TECPR1/MAP1LC3B2/CAPNS1/PLCD1/BCL2L1/UBB/TAB3/RPS6KA5/ACTN4/HK2/TIFA/ARF6	36
KEGG	hsa01522	Endocrine resistance	17/848	98/8135	0.02389	0.1959	0.171	E2F1/AKT2/PIK3R1/IGF1R/RPS6KB2/FOS/JUN/E2F2/NOTCH2/ADCY3/MAPK3/SOS2/AKT1/MTOR/MAPK13/HBEGF/NOTCH1	17
KEGG	hsa04926	Relaxin signaling pathway	21/848	129/8135	0.02533	0.2026	0.1769	ATF4/AKT2/PIK3R1/GNAI2/FOS/JUN/PLCB1/ADCY3/MAP2K7/MAPK3/SOS2/AKT1/TGFBR1/MAPK13/GNGT2/GNB3/GNG2/GNG10/GNG5/COL4A1/GNB2	21
KEGG	hsa04724	Glutamatergic synapse	19/848	114/8135	0.02595	0.2027	0.1769	SLC38A1/GRIN3B/GNAQ/GNAI2/GRIK4/PLCB1/ADCY3/PPP3CA/MAPK3/PLA2G4A/ITPR2/GNGT2/PLD1/GNB3/GRM2/GNG2/GNG10/GNG5/GNB2	19
KEGG	hsa04915	Estrogen signaling pathway	22/848	138/8135	0.02787	0.2126	0.1856	ATF4/AKT2/CTSD/GNAQ/PIK3R1/GNAI2/NCOA1/FOS/JUN/CALM3/PLCB1/KRT38/ADCY3/MAPK3/SOS2/AKT1/RARA/ITPR2/HBEGF/EBAG9/KRT23/NCOA2	22
KEGG	hsa04144	Endocytosis	36/848	251/8135	0.02895	0.2158	0.1884	CHMP1B/AP2M1/GIT1/EPS15L1/EHD1/PIP5K1B/WASL/ARPC3/RUFY2/IGF1R/PDCD6IP/CBL/SNX5/NEDD4/ACAP3/ASAP1/CBLB/AP2A2/RAB11FIP2/SH3GL1/AGAP6/AP2A1/PIP5K1C/TGFBR1/ARPC2/SH3GLB2/PARD6B/PLD1/SPG21/HLA-G/VPS28/ARAP3/AGAP1/FOLR3/PSD3/ARF6	36
KEGG	hsa04912	GnRH signaling pathway	16/848	93/8135	0.02988	0.2178	0.1901	ATF4/GNAQ/JUN/CALM3/PLCB1/ADCY3/MAP2K7/MAPK3/SOS2/PLA2G4A/ITPR2/MAPK13/HBEGF/MAP3K3/PLD1/GNRH2	16
KEGG	hsa04611	Platelet activation	20/848	124/8135	0.03124	0.2219	0.1937	AKT2/GNAQ/PIK3R1/GNAI2/FCER1G/MYL12A/VWF/PRKG1/PLCB1/TBXAS1/ADCY3/MAPK3/MYLK/AKT1/PLA2G4A/ITPR2/MAPK13/ARHGEF1/F2R/RASGRP1	20
KEGG	hsa04728	Dopaminergic synapse	21/848	132/8135	0.03179	0.2219	0.1937	ATF4/AKT2/GNAQ/GNAI2/FOS/PPP2R5E/CALM3/PLCB1/PPP3CA/PPP2R5D/AKT1/ITPR2/MAPK13/GNGT2/PPP2R2B/GNB3/GNG2/GNAL/GNG10/GNG5/GNB2	21
KEGG	hsa04150	mTOR signaling pathway	24/848	156/8135	0.03273	0.2236	0.1952	DVL1/RPTOR/AKT2/DDIT4/PIK3R1/IGF1R/WNT2B/RPS6KB2/RPS6KA2/AKT1S1/TSC2/CLIP1/MLST8/MAPK3/SOS2/AKT1/MTOR/RPS6KA3/PRKAA2/ATP6V1E2/STRADB/DVL2/PDPK1/DEPDC5	24
KEGG	hsa05213	Endometrial cancer	11/848	58/8135	0.03505	0.2346	0.2048	AXIN1/AKT2/PIK3R1/APC2/MAPK3/SOS2/AKT1/APC/CTNNA1/PDPK1/DDB2	11
KEGG	hsa04370	VEGF signaling pathway	11/848	59/8135	0.03919	0.2571	0.2244	AKT2/PIK3R1/SPHK2/PPP3CA/PTGS2/MAPK3/AKT1/PLA2G4A/MAPK13/RAC2/SPHK1	11
KEGG	hsa00531	Glycosaminoglycan degradation	5/848	19/8135	0.04094	0.2615	0.2283	IDS/HYAL3/HGSNAT/HYAL1/GLB1	5
KEGG	hsa04152	AMPK signaling pathway	19/848	120/8135	0.04146	0.2615	0.2283	RPTOR/AKT2/PFKFB2/G6PC/PIK3R1/SCD/IGF1R/RPS6KB2/PPP2R5E/AKT1S1/TSC2/PPP2R5D/AKT1/MTOR/PRKAA2/STRADB/PPP2R2B/PDPK1/HMGCR	19
KEGG	hsa04725	Cholinergic synapse	18/848	113/8135	0.04401	0.2723	0.2377	ATF4/AKT2/GNAQ/PIK3R1/GNAI2/FOS/PLCB1/ADCY3/MAPK3/AKT1/ITPR2/GNGT2/GNB3/CHRNA7/GNG2/GNG10/GNG5/GNB2	18
KEGG	hsa05214	Glioma	13/848	75/8135	0.04483	0.2723	0.2377	E2F1/AKT2/PIK3R1/IGF1R/CDK6/CALM3/E2F2/MAPK3/SOS2/AKT1/MTOR/PDGFRB/DDB2	13
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/848	26/8135	0.04713	0.2792	0.2438	PIGQ/MPPE1/PIGN/PIGG/PIGX/PIGK	6
KEGG	hsa03460	Fanconi anemia pathway	10/848	54/8135	0.04991	0.2792	0.2438	FAN1/SLX4/PMS2/FANCB/POLI/TOP3B/REV3L/UBE2T/REV1/TOP3A	10
KEGG	hsa04130	SNARE interactions in vesicular transport	7/848	33/8135	0.05009	0.2792	0.2438	STX16/USE1/STX3/STX1A/STX6/VAMP5/VAMP2	7
KEGG	hsa04973	Carbohydrate digestion and absorption	9/848	47/8135	0.05088	0.2792	0.2438	AKT2/G6PC/PIK3R1/PLCB1/MGAM/AKT1/SLC37A4/HK2/TAS1R3	9
KEGG	hsa04726	Serotonergic synapse	18/848	115/8135	0.05097	0.2792	0.2438	GNAQ/GNAI2/ALOX12/PLCB1/SLC6A4/PTGS2/MAPK3/PLA2G4A/ITPR2/GNGT2/GNB3/TPH2/HTR1D/GABRB1/GNG2/GNG10/GNG5/GNB2	18
KEGG	hsa05203	Viral carcinogenesis	29/848	204/8135	0.05108	0.2792	0.2438	ATF4/GTF2H2/SRF/SCRIB/USP7/HDAC7/UBE3A/PIK3R1/HDAC9/CREBBP/CDK6/EGR3/EP300/JUN/CCNE1/MAD1L1/DDX3X/CHD4/DDB1/GTF2E1/MAPK3/VDAC3/JAK1/RBL1/PKM/HLA-G/HDAC5/ACTN4/EIF2AK2	29
KEGG	hsa03013	Nucleocytoplasmic transport	17/848	108/8135	0.05424	0.2916	0.2546	NUP153/POM121/NUP210/NXF1/NUP210L/TPR/XPOT/XPO6/NXF3/UPF2/DDX39B/PNN/CASC3/NUP160/TNPO2/AHCTF1/UPF3B	17
KEGG	hsa04012	ErbB signaling pathway	14/848	85/8135	0.05549	0.2936	0.2563	AKT2/ABL1/PIK3R1/RPS6KB2/JUN/CBL/CBLB/MAP2K7/MAPK3/SOS2/AKT1/GAB1/MTOR/HBEGF	14
KEGG	hsa04721	Synaptic vesicle cycle	13/848	78/8135	0.05863	0.3052	0.2664	AP2M1/AP2A2/SLC6A4/STX3/AP2A1/STX1A/STXBP1/ATP6V1E2/UNC13A/VAMP2/ATP6V0A2/ATP6V0E1/RAB3A	13
KEGG	hsa04914	Progesterone-mediated oocyte maturation	16/848	102/8135	0.06213	0.3135	0.2737	AKT2/CPEB4/ANAPC5/PIK3R1/IGF1R/GNAI2/RPS6KA2/MAD1L1/PDE3B/ADCY3/MAPK3/AKT1/MAPK13/RPS6KA3/KIF22/PKMYT1	16
KEGG	hsa05142	Chagas disease	16/848	102/8135	0.06213	0.3135	0.2737	AKT2/GNAQ/PIK3R1/IRAK1/GNAI2/FOS/JUN/PLCB1/MAPK3/AKT1/TGFBR1/TLR9/MAPK13/PPP2R2B/CALR/GNAL	16
KEGG	hsa05017	Spinocerebellar ataxia	21/848	143/8135	0.06619	0.3244	0.2832	AKT2/CIC/KCNC3/GRIN3B/GNAQ/NFYA/PIK3R1/PSMD8/PLCB1/ATG14/ATXN2/SLC25A5/VDAC3/AKT1/SLC25A6/MTOR/ITPR2/PSMB7/ATP2A1/ATXN1L/ATXN10	21
KEGG	hsa04151	PI3K-Akt signaling pathway	46/848	354/8135	0.06627	0.3244	0.2832	ATF4/RPTOR/AKT2/ITGA4/DDIT4/FLT4/MCL1/G6PC/PIK3R1/IGF1R/ANGPT1/RPS6KB2/CDK6/THBS3/PPP2R5E/CCNE1/CSF3R/VWF/TSC2/TNXB/MAGI2/MLST8/PPP2R5D/MAPK3/SOS2/AKT1/JAK1/MTOR/PDGFRB/COL9A1/PRKAA2/GNGT2/PPP2R2B/F2R/GNB3/PDPK1/BCL2L1/THBS1/CDC37/GNG2/GNG10/GNG5/COL4A1/MYB/GNB2/FGF8	46
KEGG	hsa04137	Mitophagy - animal	12/848	72/8135	0.06748	0.3255	0.2841	UBC/ATF4/E2F1/PGAM5/JUN/GABARAPL1/GABARAP/TFE3/MAP1LC3B2/TBC1D17/BCL2L1/UBB	12
KEGG	hsa04210	Apoptosis	20/848	136/8135	0.07086	0.3296	0.2877	ATF4/AKT2/LMNB1/TUBA1C/MCL1/CTSD/PIK3R1/TUBA1A/FOS/JUN/HTRA2/TNFRSF10B/MAPK3/AKT1/ITPR2/LMNA/BCL2A1/PDPK1/BCL2L1/CASP2	20
KEGG	hsa00510	N-Glycan biosynthesis	9/848	50/8135	0.07092	0.3296	0.2877	MAN2A1/MOGS/B4GALT3/MGAT4A/MGAT5/STT3B/RPN1/MAN2A2/DPM3	9
KEGG	hsa04380	Osteoclast differentiation	19/848	128/8135	0.07134	0.3296	0.2877	AKT2/LILRB4/JUNB/FOSB/PIK3R1/GAB2/JUND/FOS/LILRA5/JUN/MAP2K7/PPP3CA/MAPK3/OSCAR/LILRA1/AKT1/TGFBR1/JAK1/MAPK13	19
KEGG	hsa04919	Thyroid hormone signaling pathway	18/848	121/8135	0.07639	0.3441	0.3004	AKT2/PFKFB2/MED13L/PIK3R1/NCOA1/CREBBP/EP300/TSC2/PLCB1/NOTCH2/MAPK3/AKT1/MTOR/NOTCH1/ATP2A1/PDPK1/PLCD1/NCOA2	18
KEGG	hsa04713	Circadian entrainment	15/848	97/8135	0.07658	0.3441	0.3004	GNAQ/GNAI2/FOS/CALM3/PRKG1/PLCB1/ADCY3/MAPK3/GNGT2/GNB3/RPS6KA5/GNG2/GNG10/GNG5/GNB2	15
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	30/848	222/8135	0.08188	0.3629	0.3168	ATF4/E2F1/AKT2/SRF/ANAPC5/NFATC3/PIK3R1/CREBBP/FOS/EP300/IL15RA/JUN/CCNE1/MAD1L1/E2F2/ADCY3/PPP3CA/MAPK3/SLC25A5/VDAC3/AKT1/TGFBR1/ZFP36/JAK1/SLC25A6/CALR/MAP3K3/LTA/HLA-G/BCL2L1	30
KEGG	hsa03430	Mismatch repair	5/848	23/8135	0.08399	0.3648	0.3185	LIG1/POLD4/PMS2/MSH6/PCNA	5
KEGG	hsa04720	Long-term potentiation	11/848	67/8135	0.0848	0.3648	0.3185	ATF4/GNAQ/CREBBP/RPS6KA2/EP300/CALM3/PLCB1/PPP3CA/MAPK3/ITPR2/RPS6KA3	11
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/848	223/8135	0.08564	0.3648	0.3185	AKT2/ABL1/GSTA4/PIK3R1/PTPN1/NDUFS7/FOS/EPHX1/JUN/GSTM1/NOX4/MAP2K7/NDUFV1/MAPK3/SLC25A5/SOS2/VDAC3/AKT1/MGST3/SLC25A6/MAPK13/NDUFA4/NDUFA10/PLD1/NDUFA7/COX6C/PDPK1/NDUFB7/NDUFA12/NDUFS8	30
KEGG	hsa04922	Glucagon signaling pathway	16/848	107/8135	0.08772	0.3689	0.322	ATF4/AKT2/G6PC/GNAQ/CREBBP/PRMT1/EP300/CALM3/PDE3B/PLCB1/PPP3CA/AKT1/ITPR2/PRKAA2/PKM/PHKA2	16
KEGG	hsa05160	Hepatitis C	22/848	157/8135	0.09151	0.3765	0.3287	E2F1/AKT2/OCLN/CLDN6/PIK3R1/CDK6/SCARB1/E2F2/PSME3/RSAD2/EIF2AK4/MAPK3/SOS2/AKT1/JAK1/OAS2/OAS3/PPP2R2B/IFIT1/MX1/EIF2AK2/CLDN10	22
KEGG	hsa05226	Gastric cancer	21/848	149/8135	0.09309	0.3765	0.3287	DVL1/AXIN1/E2F1/AKT2/PIK3R1/WNT2B/RPS6KB2/CCNE1/APC2/E2F2/MAPK3/SOS2/AKT1/TGFBR1/GAB1/MTOR/APC/CTNNA1/DVL2/DDB2/FGF8	21
KEGG	hsa04931	Insulin resistance	16/848	108/8135	0.09354	0.3765	0.3287	AKT2/G6PC/PIK3R1/PTPN1/RPS6KB2/RPS6KA2/SLC27A4/AKT1/MTOR/PPP1R3D/MLXIP/PPP1R3E/RPS6KA3/PRKAA2/PDPK1/SLC27A1	16
KEGG	hsa04658	Th1 and Th2 cell differentiation	14/848	92/8135	0.09429	0.3765	0.3287	NFATC3/STAT6/MAML3/FOS/JUN/RUNX3/NOTCH2/PPP3CA/TBX21/MAPK3/JAK1/MAPK13/NOTCH1/STAT4	14
KEGG	hsa00052	Galactose metabolism	6/848	31/8135	0.0971	0.3765	0.3287	G6PC/MGAM/PGM1/GLB1/GANC/HK2	6
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/848	24/8135	0.09743	0.3765	0.3287	XYLT1/XYLT2/HS6ST1/HS3ST3B1/HS3ST3A1	5
KEGG	hsa04022	cGMP-PKG signaling pathway	23/848	167/8135	0.09946	0.3765	0.3287	ATF4/AKT2/SRF/NFATC3/GNAQ/GNAI2/CALM3/SLC8A1/PDE3B/PRKG1/RGS2/PLCB1/ADCY3/PPP3CA/MAPK3/SLC25A5/VDAC3/MYLK/AKT1/SLC25A6/ITPR2/KCNMA1/ATP2A1	23
KEGG	hsa04310	Wnt signaling pathway	23/848	167/8135	0.09946	0.3765	0.3287	DVL1/AXIN1/NLK/SFRP1/NFATC3/CREBBP/WNT2B/GPC4/EP300/JUN/SIAH1/APC2/PLCB1/DAAM2/PPP3CA/TLE3/APC/TLE1/SKP1/RAC2/DVL2/LGR5/CTBP2	23
KEGG	hsa05211	Renal cell carcinoma	11/848	69/8135	0.09986	0.3765	0.3287	AKT2/PIK3R1/CREBBP/EP300/JUN/RAPGEF1/TFE3/MAPK3/SOS2/AKT1/GAB1	11
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/848	143/8135	0.1054	0.3845	0.3356	DVL1/AXIN1/AKT2/INHBA/INHBC/ACVR1B/PIK3R1/IGF1R/WNT2B/KAT6A/APC2/ZFHX3/KLF4/MAPK3/AKT1/JAK1/APC/MAPK13/HESX1/DVL2	20
KEGG	hsa00513	Various types of N-glycan biosynthesis	7/848	39/8135	0.1054	0.3845	0.3356	MAN2A1/B4GALT3/MGAT4A/STT3B/RPN1/MAN2A2/B4GALNT3	7
KEGG	hsa05016	Huntington disease	39/848	306/8135	0.1061	0.3845	0.3356	AP2M1/TUBA1C/TUBB4B/GNAQ/NDUFS7/TUBA1A/CREBBP/EP300/GPX2/DNAH1/PSMD8/PLCB1/ACTR1B/ATG14/AP2A2/POLR2F/DNAL1/MAP2K7/NDUFV1/MAP3K10/SLC25A5/AP2A1/VDAC3/SLC25A6/STX1A/MTOR/DNAH10/NDUFA4/NDUFA10/PSMB7/POLR2J3/NDUFA7/COX6C/TAF4/DCTN1/NDUFB7/NDUFA12/NDUFS8/TGM2	39
KEGG	hsa04213	Longevity regulating pathway - multiple species	10/848	62/8135	0.1067	0.3845	0.3356	RPTOR/AKT2/PIK3R1/IGF1R/RPS6KB2/AKT1S1/ADCY3/AKT1/MTOR/PRKAA2	10
KEGG	hsa04350	TGF-beta signaling pathway	14/848	94/8135	0.1079	0.3846	0.3357	AMH/INHBA/INHBC/ACVR1B/CREBBP/RPS6KB2/EP300/MAPK3/TGFBR1/RBL1/SKP1/BMP7/GDF5/THBS1	14
KEGG	hsa04136	Autophagy - other	6/848	32/8135	0.1095	0.3863	0.3372	RPTOR/ATG4D/GABARAPL1/GABARAP/MLST8/MTOR	6
KEGG	hsa04935	Growth hormone synthesis, secretion and action	17/848	119/8135	0.1108	0.3867	0.3376	ATF4/AKT2/JUNB/GNAQ/PIK3R1/GNAI2/CREBBP/FOS/EP300/PLCB1/ADCY3/MAPK3/SOS2/AKT1/MTOR/ITPR2/MAPK13	17
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	58/848	476/8135	0.113	0.3901	0.3405	UBC/DVL1/AXIN1/ATF4/UBE2J1/TUBA1C/TUBB4B/GNAQ/NDUFS7/TUBA1A/WNT2B/SMCR8/GPX2/CALM3/DNAH1/APC2/PSMD8/HTRA2/PLCB1/ACTR1B/ATG14/VCP/ATXN2/NOX4/DNAL1/MAP2K7/NDUFV1/PPP3CA/PTGS2/MAP3K10/MAPK3/SLC25A5/VDAC3/SLC25A6/STX1A/MTOR/ITPR2/APC/DNAH10/MAPK13/NDUFA4/NDUFA10/PSMB7/MAP1LC3B2/NDUFA7/DVL2/COX6C/ATP2A1/BCL2L1/ATXN1L/GPR37/UBB/DCTN1/NDUFB7/NDUFA12/CHRNA7/C9orf72/NDUFS8	58
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/848	79/8135	0.1165	0.3977	0.3471	AKT2/PIK3R1/IGF1R/RPS6KB2/MAPK3/SOS2/AKT1/JAK1/GAB1/MTOR/PDGFRB/BCL2L1	12
KEGG	hsa04630	JAK-STAT signaling pathway	22/848	162/8135	0.1176	0.3977	0.3471	AKT2/IL13RA1/MCL1/IL24/IL5RA/STAT6/PIK3R1/CREBBP/SOCS4/IL10RB/IL23A/EP300/IL15RA/CSF3R/IFNL1/SOS2/AKT1/JAK1/MTOR/PDGFRB/BCL2L1/STAT4	22
KEGG	hsa04660	T cell receptor signaling pathway	15/848	104/8135	0.121	0.4027	0.3515	AKT2/MALT1/NFATC3/PIK3R1/FOS/JUN/CBLB/MAP2K7/PPP3CA/MAPK3/SOS2/AKT1/MAPK13/PDPK1/RASGRP1	15
KEGG	hsa05130	Pathogenic Escherichia coli infection	26/848	197/8135	0.1224	0.4027	0.3515	OCLN/TUBA1C/CLDN6/TUBB4B/ABL1/WASL/ARPC3/IRAK1/TUBA1A/MYO1D/FOS/JUN/WASF2/TNFRSF10B/BAIAP2/MAPK3/ARPC2/TMBIM6/MAPK13/ARHGEF1/F2R/MYO1A/TAB3/MYO5A/CLDN10/ARF6	26
KEGG	hsa05152	Tuberculosis	24/848	180/8135	0.1231	0.4027	0.3515	CLEC4E/AKT2/MALT1/CTSD/KSR1/NFYA/IRAK1/SPHK2/FCER1G/CREBBP/IL10RB/IL23A/EP300/CALM3/PPP3CA/MAPK3/CD14/AKT1/JAK1/TLR9/MAPK13/CEBPB/ATP6V0A2/SPHK1	24
KEGG	hsa05218	Melanoma	11/848	72/8135	0.1252	0.4027	0.3515	E2F1/AKT2/PIK3R1/IGF1R/CDK6/E2F2/MAPK3/AKT1/PDGFRB/DDB2/FGF8	11
KEGG	hsa05223	Non-small cell lung cancer	11/848	72/8135	0.1252	0.4027	0.3515	E2F1/AKT2/PIK3R1/CDK6/E2F2/MAPK3/SOS2/AKT1/PDPK1/DDB2/RASSF1	11
KEGG	hsa05219	Bladder cancer	7/848	41/8135	0.1291	0.4111	0.3588	E2F1/E2F2/MAPK3/HBEGF/THBS1/RPS6KA5/RASSF1	7
KEGG	hsa04727	GABAergic synapse	13/848	89/8135	0.132	0.4164	0.3635	GABRR2/SLC38A1/GNAI2/GABARAPL1/GABARAP/ADCY3/GNGT2/GNB3/GABRB1/GNG2/GNG10/GNG5/GNB2	13
KEGG	hsa04115	p53 signaling pathway	11/848	73/8135	0.1344	0.4199	0.3665	RRM2/CDK6/CCNE1/SIAH1/TSC2/EI24/TNFRSF10B/PERP/BCL2L1/THBS1/DDB2	11
KEGG	hsa00380	Tryptophan metabolism	7/848	42/8135	0.1418	0.4355	0.3801	ALDH3A2/GCDH/IDO2/HADH/DHTKD1/TPH2/HAAO	7
KEGG	hsa04142	Lysosome	18/848	132/8135	0.1421	0.4355	0.3801	IDS/TPP1/PPT1/CTSD/HYAL3/HGSNAT/GM2A/AP4S1/NPC1/HYAL1/AP1M2/AP1G2/GLB1/AGA/LAMP3/ATP6V0A2/WDR7/LITAF	18
KEGG	hsa04015	Rap1 signaling pathway	27/848	210/8135	0.1462	0.444	0.3875	AKT2/FLT4/FARP2/RAPGEF2/GNAQ/PIK3R1/IGF1R/ANGPT1/GNAI2/ADORA2B/CALM3/PLCB1/RAPGEF1/MAGI2/ADCY3/MAPK3/AKT1/SIPA1L3/PDGFRB/MAPK13/PARD6B/RAC2/F2R/ARAP3/THBS1/RASGRP3/FGF8	27
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/848	20/8135	0.1483	0.4464	0.3896	CSGALNACT1/XYLT1/XYLT2/CHST11	4
KEGG	hsa05221	Acute myeloid leukemia	10/848	67/8135	0.1555	0.4638	0.4048	AKT2/PIK3R1/RPS6KB2/MAPK3/CD14/SOS2/AKT1/RARA/MTOR/BCL2A1	10
KEGG	hsa00500	Starch and sucrose metabolism	6/848	36/8135	0.1667	0.4926	0.43	G6PC/MGAM/PGM1/GANC/HK2/GYG1	6
KEGG	hsa01232	Nucleotide metabolism	12/848	85/8135	0.1712	0.5004	0.4368	AK8/RRM2/TYMS/UPP1/ASMTL/AMPD2/AK4/CMPK2/DGUOK/APRT/TK1/NT5C3A	12
KEGG	hsa04714	Thermogenesis	29/848	232/8135	0.1724	0.5004	0.4368	ARID1B/RPTOR/NDUFS7/RPS6KB2/RPS6KA2/ARID1A/SMARCC2/AKT1S1/TSC2/PRKG1/MLST8/ADCY3/NDUFV1/SMARCC1/SOS2/MTOR/COX16/MAPK13/RPS6KA3/PRKAA2/NDUFA4/NDUFA10/ZNF516/NDUFA7/COX6C/NDUFB7/NDUFA12/NDUFS8/SLC25A29	29
KEGG	hsa05164	Influenza A	22/848	171/8135	0.1749	0.5025	0.4386	AKT2/PIK3R1/CREBBP/NXF1/CDK6/PABPN1L/EP300/RSAD2/HNRNPUL1/TNFRSF10B/NXF3/MAPK3/SLC25A5/TPSB2/AKT1/JAK1/SLC25A6/OAS2/OAS3/CPSF4L/MX1/EIF2AK2	22
KEGG	hsa04657	IL-17 signaling pathway	13/848	94/8135	0.1772	0.5025	0.4386	FOSB/ANAPC5/JUND/FOS/JUN/CXCL1/LCN2/PTGS2/MAPK3/MAPK13/CEBPB/TAB3/S100A7	13
KEGG	hsa04921	Oxytocin signaling pathway	20/848	154/8135	0.1777	0.5025	0.4386	MYL6B/NFATC3/GNAQ/GNAI2/FOS/JUN/CALM3/RGS2/PLCB1/CACNB4/ADCY3/PPP3CA/PTGS2/MAPK3/MYLK/PLA2G4A/ITPR2/PRKAA2/TRPM2/CACNA2D1	20
KEGG	hsa05143	African trypanosomiasis	6/848	37/8135	0.1826	0.5099	0.4451	GNAQ/IDO2/HBB/PLCB1/TLR9/HBA2	6
KEGG	hsa03022	Basal transcription factors	7/848	45/8135	0.1834	0.5099	0.4451	GTF2H2/TAF7/TAF3/TAF6/GTF2E1/TAF1/TAF4	7
KEGG	hsa04934	Cushing syndrome	20/848	155/8135	0.1853	0.5108	0.4459	DVL1/AXIN1/ATF4/E2F1/GNAQ/GNAI2/WNT2B/CDK6/CCNE1/CRHR2/SCARB1/APC2/E2F2/PLCB1/ADCY3/MAPK3/ITPR2/APC/KMT2D/DVL2	20
KEGG	hsa05162	Measles	18/848	139/8135	0.1965	0.5372	0.469	AKT2/PIK3R1/IRAK1/CDK6/FOS/JUN/CCNE1/MSN/CBLB/EIF2AK4/AKT1/JAK1/TLR9/OAS2/OAS3/BCL2L1/MX1/EIF2AK2	18
KEGG	hsa04062	Chemokine signaling pathway	24/848	192/8135	0.1997	0.5403	0.4716	AKT2/CX3CR1/GNAQ/PIK3R1/XCL1/GNAI2/CCR2/XCL2/PLCB1/CXCL1/ADCY3/MAPK3/SOS2/AKT1/CCL28/CX3CL1/GNGT2/RAC2/GNB3/DOCK2/GNG2/GNG10/GNG5/GNB2	24
KEGG	hsa04114	Oocyte meiosis	17/848	131/8135	0.2025	0.5403	0.4716	CPEB4/ANAPC5/IGF1R/RPS6KA2/PPP2R5E/CCNE1/MAD1L1/CALM3/ADCY3/PPP3CA/PPP2R5D/MAPK3/ITPR2/SKP1/MAPK13/RPS6KA3/PKMYT1	17
KEGG	hsa04540	Gap junction	12/848	88/8135	0.2026	0.5403	0.4716	TUBA1C/TUBB4B/GNAQ/GNAI2/TUBA1A/PRKG1/PLCB1/ADCY3/MAPK3/SOS2/ITPR2/PDGFRB	12
KEGG	hsa00310	Lysine degradation	9/848	63/8135	0.2059	0.5446	0.4754	COLGALT2/ALDH3A2/GCDH/ASH1L/NSD1/HADH/DHTKD1/KMT2D/TMLHE	9
KEGG	hsa04070	Phosphatidylinositol signaling system	13/848	97/8135	0.2075	0.5446	0.4754	PIP5K1B/PIK3R1/IMPA2/PI4KA/CALM3/PLCB1/INPP1/ITPKC/INPP5A/CDS2/PIP5K1C/ITPR2/PLCD1	13
KEGG	hsa05014	Amyotrophic lateral sclerosis	43/848	364/8135	0.2097	0.5459	0.4765	ATF4/TUBA1C/TUBB4B/NUP153/POM121/NUP210/NDUFS7/TUBA1A/NXF1/SMCR8/NUP210L/UBQLN1/TPR/GPX2/DNAH1/PSMD8/ACTR1B/ATG14/VCP/ATXN2/NXF3/DNAL1/NDUFV1/PPP3CA/HNRNPA1L2/MTOR/DNAH10/MAPK13/NDUFA4/NDUFA10/PSMB7/MAP1LC3B2/NDUFA7/COX6C/BCL2L1/DCTN1/ANXA7/NDUFB7/NDUFA12/C9orf72/NDUFS8/NUP160/HNRNPA2B1	43
KEGG	hsa03060	Protein export	4/848	23/8135	0.2132	0.5473	0.4778	SEC62/SRP14/SEC61G/SRP9	4
KEGG	hsa04211	Longevity regulating pathway	12/848	89/8135	0.2136	0.5473	0.4778	ATF4/RPTOR/AKT2/PIK3R1/IGF1R/RPS6KB2/AKT1S1/TSC2/ADCY3/AKT1/MTOR/PRKAA2	12
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	19/848	150/8135	0.2157	0.5486	0.4789	ATF4/AKT2/GNAQ/GNAI2/PPP2R5E/TPM4/CALM3/SLC8A1/PLCB1/CACNB4/ADCY3/PPP2R5D/MAPK3/AKT1/MAPK13/PPP2R2B/ATP2A1/CACNA2D1/RPS6KA5	19
KEGG	hsa00564	Glycerophospholipid metabolism	13/848	98/8135	0.2181	0.5504	0.4804	AGPAT1/MBOAT1/ETNPPL/LCAT/PCYT2/CDS2/LPCAT1/PLA2G4A/AGPAT2/PLD1/PLA2G2C/LPCAT4/PCYT1B	13
KEGG	hsa04923	Regulation of lipolysis in adipocytes	8/848	56/8135	0.2245	0.562	0.4906	AKT2/PIK3R1/GNAI2/PDE3B/PRKG1/ADCY3/PTGS2/AKT1	8
KEGG	hsa00562	Inositol phosphate metabolism	10/848	73/8135	0.2262	0.562	0.4906	PIP5K1B/IMPA2/PI4KA/PLCB1/INPP1/ITPKC/INPP5A/PIP5K1C/PLCD1/MINPP1	10
KEGG	hsa04977	Vitamin digestion and absorption	4/848	24/8135	0.2363	0.5811	0.5072	LRAT/SCARB1/SLC5A6/TCN2	4
KEGG	hsa04110	Cell cycle	16/848	126/8135	0.2374	0.5811	0.5072	E2F1/ABL1/ANAPC5/CREBBP/CDK6/EP300/CCNE1/MAD1L1/CDKN2D/E2F2/STAG1/RBL1/SKP1/CDKN1C/PCNA/PKMYT1	16
KEGG	hsa01212	Fatty acid metabolism	8/848	57/8135	0.2392	0.5811	0.5072	TECR/PPT1/SCD/HADH/SCP2/ELOVL6/ACADVL/ACSBG2	8
KEGG	hsa05222	Small cell lung cancer	12/848	92/8135	0.248	0.5982	0.5221	E2F1/AKT2/PIK3R1/CDK6/CKS1B/CCNE1/E2F2/PTGS2/AKT1/BCL2L1/DDB2/COL4A1	12
KEGG	hsa03410	Base excision repair	5/848	33/8135	0.2569	0.6096	0.5322	HMGB1/LIG1/OGG1/POLD4/PCNA	5
KEGG	hsa00120	Primary bile acid biosynthesis	3/848	17/8135	0.2581	0.6096	0.5322	AMACR/SCP2/ACOT8	3
KEGG	hsa04932	Non-alcoholic fatty liver disease	19/848	155/8135	0.2603	0.6096	0.5322	ATF4/AKT2/PIK3R1/NDUFS7/FOS/JUN/MAP3K11/NDUFV1/AKT1/MLXIP/MAPK13/PRKAA2/NDUFA4/NDUFA10/NDUFA7/COX6C/NDUFB7/NDUFA12/NDUFS8	19
KEGG	hsa04810	Regulation of actin cytoskeleton	26/848	218/8135	0.2609	0.6096	0.5322	IQGAP2/ITGA4/GIT1/PIP5K1B/WASL/ARPC3/PIK3R1/MYL12A/MSN/APC2/WASF2/SSH1/BAIAP2/MAPK3/SOS2/MYLK/PIP5K1C/ARPC2/APC/PDGFRB/ARHGEF1/RAC2/F2R/ARHGEF6/ACTN4/FGF8	26
KEGG	hsa05144	Malaria	7/848	50/8135	0.2621	0.6096	0.5322	KLRK1/THBS3/HBB/GYPC/TLR9/HBA2/THBS1	7
KEGG	hsa05133	Pertussis	10/848	76/8135	0.2655	0.6132	0.5353	IRAK1/GNAI2/FOS/IL23A/JUN/CALM3/MAPK3/CD14/MAPK13/SERPING1	10
KEGG	hsa04610	Complement and coagulation cascades	11/848	85/8135	0.2692	0.6139	0.5359	C5AR1/CD55/CFD/VWF/C3AR1/F2R/CD59/CLU/CPB2/THBD/SERPING1	11
KEGG	hsa04510	Focal adhesion	24/848	201/8135	0.2695	0.6139	0.5359	AKT2/ITGA4/FLT4/PIP5K1B/PIK3R1/IGF1R/THBS3/MYL12A/JUN/VWF/TNXB/RAPGEF1/MAPK3/SOS2/MYLK/PIP5K1C/AKT1/PDGFRB/COL9A1/RAC2/PDPK1/THBS1/ACTN4/COL4A1	24
KEGG	hsa05169	Epstein-Barr virus infection	24/848	202/8135	0.2778	0.627	0.5473	E2F1/AKT2/USP7/PIK3R1/IRAK1/CDK6/ISG15/JUN/CCNE1/NCOR2/NEDD4/PSMD8/RUNX3/E2F2/MAP2K7/AKT1/JAK1/MAPK13/OAS2/OAS3/CALR/HLA-G/DDB2/EIF2AK2	24
KEGG	hsa04390	Hippo signaling pathway	19/848	157/8135	0.2791	0.627	0.5473	DVL1/AXIN1/AMH/WWTR1/SCRIB/WNT2B/AMOT/LLGL1/APC2/LLGL2/TGFBR1/APC/PARD6B/CTNNA1/BMP7/PPP2R2B/DVL2/GDF5/RASSF1	19
KEGG	hsa04730	Long-term depression	8/848	60/8135	0.2851	0.6274	0.5477	GNAQ/IGF1R/GNAI2/PRKG1/PLCB1/MAPK3/PLA2G4A/ITPR2	8
KEGG	hsa00511	Other glycan degradation	3/848	18/8135	0.2876	0.6274	0.5477	GBA2/GLB1/AGA	3
KEGG	hsa00071	Fatty acid degradation	6/848	43/8135	0.2886	0.6274	0.5477	ALDH3A2/ECI1/GCDH/HADH/ACADVL/ACSBG2	6
KEGG	hsa04975	Fat digestion and absorption	6/848	43/8135	0.2886	0.6274	0.5477	AGPAT1/SCARB1/SLC27A4/AGPAT2/PLA2G2C/SLC27A1	6
KEGG	hsa05132	Salmonella infection	29/848	249/8135	0.2897	0.6274	0.5477	AKT2/TUBA1C/TUBB4B/WASL/ARPC3/IRAK1/TUBA1A/MYL12A/FOS/JUN/PLEKHM1/ACTR1B/TNFRSF10B/RILP/MAP2K7/MAPK3/CD14/AKT1/TLR9/ARPC2/SKP1/MAPK13/VPS16/RHOH/TAB3/DCTN1/PLEKHM2/DYNLRB1/ARF6	29
KEGG	hsa04020	Calcium signaling pathway	28/848	240/8135	0.2908	0.6274	0.5477	FLT4/CYSLTR2/GNAQ/SPHK2/ADORA2B/CALM3/SLC8A1/PLCB1/ADCY3/ITPKC/PPP3CA/SLC25A5/VDAC3/MYLK/SLC25A6/ITPR2/PDGFRB/F2R/PHKA2/ATP2A1/PLCD1/SPHK1/HRH2/CHRNA7/GNAL/HRH1/LTB4R2/FGF8	28
KEGG	hsa00600	Sphingolipid metabolism	7/848	52/8135	0.2959	0.6343	0.5537	SPTLC3/SPHK2/GBA2/CERS6/GLB1/SPHK1/CERS2	7
KEGG	hsa05230	Central carbon metabolism in cancer	9/848	70/8135	0.3043	0.6422	0.5606	AKT2/PIK3R1/MAPK3/AKT1/MTOR/PDGFRB/PKM/SIRT3/HK2	9
KEGG	hsa03018	RNA degradation	10/848	79/8135	0.3067	0.6422	0.5606	TOB2/EXOSC6/MPHOSPH6/BTG2/PABPC1/PABPC4/CNOT10/DCP1B/PNPT1/EXOSC5	10
KEGG	hsa00062	Fatty acid elongation	4/848	27/8135	0.3086	0.6422	0.5606	TECR/PPT1/HADH/ELOVL6	4
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/848	27/8135	0.3086	0.6422	0.5606	TECR/SCD/SCP2/ELOVL6	4
KEGG	hsa04120	Ubiquitin mediated proteolysis	17/848	142/8135	0.3094	0.6422	0.5606	UBC/HERC3/UBE2J1/ANAPC5/UBE3A/SIAH1/CBL/UBE2M/NEDD4/CUL7/CBLB/DDB1/SKP1/HERC1/STUB1/UBB/DDB2	17
KEGG	hsa03030	DNA replication	5/848	36/8135	0.3199	0.6599	0.576	POLA2/LIG1/DNA2/POLD4/PCNA	5
KEGG	hsa04659	Th17 cell differentiation	13/848	108/8135	0.3344	0.6855	0.5983	NFATC3/STAT6/FOS/IL23A/JUN/PPP3CA/TBX21/MAPK3/TGFBR1/RARA/JAK1/MTOR/MAPK13	13
KEGG	hsa04930	Type II diabetes mellitus	6/848	46/8135	0.3458	0.6943	0.6061	PIK3R1/SOCS4/MAPK3/MTOR/PKM/HK2	6
KEGG	hsa00100	Steroid biosynthesis	3/848	20/8135	0.3473	0.6943	0.6061	CYP2R1/CYP51A1/HSD17B7	3
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/848	100/8135	0.3479	0.6943	0.6061	AKT2/PIK3R1/JUN/PLCB1/NOX4/MAPK3/AKT1/TGFBR1/MAPK13/PLCD1/THBD/COL4A1	12
KEGG	hsa05032	Morphine addiction	11/848	91/8135	0.3488	0.6943	0.6061	GABRR2/GNAI2/PDE3B/ADCY3/GNGT2/GNB3/GABRB1/GNG2/GNG10/GNG5/GNB2	11
KEGG	hsa04929	GnRH secretion	8/848	64/8135	0.3493	0.6943	0.6061	AKT2/GNAQ/PIK3R1/PLCB1/MAPK3/AKT1/ITPR2/GNRH2	8
KEGG	hsa00514	Other types of O-glycan biosynthesis	6/848	47/8135	0.3651	0.7214	0.6297	COLGALT2/B4GALT3/POMT1/POFUT1/MFNG/GALNT2	6
KEGG	hsa00030	Pentose phosphate pathway	4/848	30/8135	0.3826	0.7516	0.656	PRPS1/RPIA/H6PD/PGM1	4
KEGG	hsa04974	Protein digestion and absorption	12/848	103/8135	0.3872	0.7559	0.6598	COL18A1/SLC7A7/COL17A1/SLC8A1/SLC7A8/SLC36A3/COL9A1/CELA2B/COL13A1/CPB2/COL4A1/SLC15A1	12
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	15/848	131/8135	0.3905	0.758	0.6616	NCR3/PIK3R1/KLRK1/FCER1G/SH3BP2/KIR2DL1/ULBP2/TNFRSF10B/PPP3CA/MAPK3/SOS2/KLRD1/RAC2/KIR2DS4/HLA-G	15
KEGG	hsa00240	Pyrimidine metabolism	7/848	58/8135	0.4013	0.7701	0.6723	RRM2/TYMS/UPP1/ASMTL/CMPK2/TK1/NT5C3A	7
KEGG	hsa00565	Ether lipid metabolism	6/848	49/8135	0.4038	0.7701	0.6723	LPCAT1/PLA2G4A/ENPP6/PLD1/PLA2G2C/LPCAT4	6
KEGG	hsa05030	Cocaine addiction	6/848	49/8135	0.4038	0.7701	0.6723	ATF4/FOSB/GRIN3B/GNAI2/JUN/GRM2	6
KEGG	hsa04670	Leukocyte transendothelial migration	13/848	114/8135	0.4096	0.7707	0.6727	OCLN/ITGA4/CLDN6/PIK3R1/GNAI2/MYL12A/MSN/MAPK13/CTNNA1/RAC2/RHOH/ACTN4/CLDN10	13
KEGG	hsa04936	Alcoholic liver disease	16/848	142/8135	0.4101	0.7707	0.6727	C5AR1/AKT2/ALDH3A2/SCD/IRAK1/TRA2A/CXCL1/NOX4/MAP2K7/CD14/AKT1/MAPK13/PRKAA2/C3AR1/ACADVL/TAB3	16
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/848	77/8135	0.4112	0.7707	0.6727	ITGA4/SLC8A1/CACNB4/SGCA/LMNA/CTNNA1/DSP/ATP2A1/CACNA2D1	9
KEGG	hsa04141	Protein processing in endoplasmic reticulum	19/848	171/8135	0.4201	0.7819	0.6826	ATF4/UBE2J1/RAD23B/MOGS/SEC62/UBQLN1/STT3B/VCP/EIF2AK4/MAP2K7/RPN1/MBTPS1/SKP1/CALR/STUB1/SEC61G/EIF2AK2/FBXO6/SVIP	19
KEGG	hsa05110	Vibrio cholerae infection	6/848	50/8135	0.4232	0.7819	0.6826	ADCY3/KDELR1/ATP6V1E2/ATP6V0A2/SEC61G/ATP6V0E1	6
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	12/848	106/8135	0.4268	0.7819	0.6826	ATF4/GNAQ/GNAI2/JUND/FOS/PLCB1/ADCY3/MAPK3/ITPR2/HBEGF/ARHGEF1/PLD1	12
KEGG	hsa03440	Homologous recombination	5/848	41/8135	0.4274	0.7819	0.6826	UIMC1/POLD4/TOP3B/RAD51D/TOP3A	5
KEGG	hsa04924	Renin secretion	8/848	69/8135	0.4315	0.7819	0.6826	GNAQ/GNAI2/CALM3/PDE3B/PLCB1/PPP3CA/ITPR2/KCNMA1	8
KEGG	hsa05031	Amphetamine addiction	8/848	69/8135	0.4315	0.7819	0.6826	ATF4/FOSB/GRIN3B/FOS/JUN/CALM3/PPP3CA/STX1A	8
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/848	23/8135	0.4354	0.7828	0.6833	B4GALT3/FKRP/POMT1	3
KEGG	hsa05416	Viral myocarditis	7/848	60/8135	0.4367	0.7828	0.6833	CD55/ABL1/EIF4G2/EIF4G1/SGCA/RAC2/HLA-G	7
KEGG	hsa04913	Ovarian steroidogenesis	6/848	51/8135	0.4424	0.7887	0.6884	IGF1R/SCARB1/ADCY3/PTGS2/PLA2G4A/HSD17B7	6
KEGG	hsa04917	Prolactin signaling pathway	8/848	70/8135	0.4479	0.7898	0.6895	AKT2/PIK3R1/SOCS4/FOS/MAPK3/SOS2/AKT1/MAPK13	8
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/848	70/8135	0.4479	0.7898	0.6895	GIT1/JUN/CXCL1/MAPK13/HBEGF/ATP6V1E2/ATP6V0A2/ATP6V0E1	8
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	23/848	212/8135	0.4524	0.7935	0.6927	ATF4/E2F1/AKT2/GSTA4/PIK3R1/GNAI2/RPS6KB2/RPS6KA2/FOS/EPHX1/JUN/GSTM1/NOTCH2/ADCY3/KLF4/MAPK3/SOS2/AKT1/MGST3/MTOR/RPS6KA3/CHRNA7/FGF8	23
KEGG	hsa05415	Diabetic cardiomyopathy	22/848	203/8135	0.457	0.7974	0.696	AKT2/CTSD/PIK3R1/NDUFS7/PLCB1/NDUFV1/SLC25A5/VDAC3/AKT1/TGFBR1/SLC25A6/MTOR/MAPK13/NDUFA4/NDUFA10/RAC2/NDUFA7/COX6C/ATP2A1/NDUFB7/NDUFA12/NDUFS8	22
KEGG	hsa05010	Alzheimer disease	41/848	384/8135	0.4598	0.7979	0.6965	DVL1/AXIN1/ATF4/AKT2/TUBA1C/TUBB4B/GNAQ/PIK3R1/NDUFS7/TUBA1A/WNT2B/CALM3/APC2/PSMD8/PLCB1/ATG14/NOX4/MAP2K7/NDUFV1/PPP3CA/PTGS2/MAPK3/SLC25A5/VDAC3/AKT1/SLC25A6/MTOR/ITPR2/APC/NDUFA4/NDUFA10/PSMB7/NDUFA7/DVL2/COX6C/ATP2A1/NDUFB7/NDUFA12/CHRNA7/NDUFS8/EIF2AK2	41
KEGG	hsa04066	HIF-1 signaling pathway	12/848	109/8135	0.4664	0.8052	0.7029	AKT2/MKNK2/PIK3R1/IGF1R/ANGPT1/CREBBP/RPS6KB2/EP300/MAPK3/AKT1/MTOR/HK2	12
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/848	100/8135	0.473	0.8089	0.7061	IL24/CX3CR1/XCL1/IL10RB/CCR2/XCL2/CXCL1/TNFRSF10B/CCL28/CX3CL1/LTA	11
KEGG	hsa00730	Thiamine metabolism	2/848	15/8135	0.4735	0.8089	0.7061	AK8/AK4	2
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/848	53/8135	0.4805	0.8166	0.7128	AP2M1/GNAQ/SLC8A1/PLCB1/AP2A2/AP2A1	6
KEGG	hsa05418	Fluid shear stress and atherosclerosis	15/848	139/8135	0.4845	0.8186	0.7146	AKT2/GSTA4/KLF2/PIK3R1/FOS/JUN/GSTM1/CALM3/MAP2K7/AKT1/MGST3/MAPK13/PRKAA2/RAC2/THBD	15
KEGG	hsa04916	Melanogenesis	11/848	101/8135	0.4867	0.8186	0.7146	DVL1/GNAQ/GNAI2/CREBBP/WNT2B/EP300/CALM3/PLCB1/ADCY3/MAPK3/DVL2	11
KEGG	hsa05217	Basal cell carcinoma	7/848	63/8135	0.4892	0.8187	0.7146	DVL1/AXIN1/WNT2B/APC2/APC/DVL2/DDB2	7
KEGG	hsa00360	Phenylalanine metabolism	2/848	16/8135	0.5085	0.8423	0.7353	AOC3/AOC2	2
KEGG	hsa05012	Parkinson disease	28/848	266/8135	0.5085	0.8423	0.7353	UBC/ATF4/UBE2J1/TUBA1C/TUBB4B/NDUFS7/GNAI2/TUBA1A/CALM3/PSMD8/HTRA2/NDUFV1/SLC25A5/VDAC3/SLC25A6/ITPR2/NDUFA4/NDUFA10/PSMB7/NDUFA7/COX6C/BCL2L1/GPR37/UBB/NDUFB7/NDUFA12/NDUFS8/GNAL	28
KEGG	hsa04620	Toll-like receptor signaling pathway	11/848	104/8135	0.5272	0.869	0.7586	AKT2/PIK3R1/IRAK1/FOS/JUN/MAP2K7/MAPK3/CD14/AKT1/TLR9/MAPK13	11
KEGG	hsa04270	Vascular smooth muscle contraction	14/848	134/8135	0.5387	0.8835	0.7712	MYL6B/GNAQ/ADORA2B/CALM3/PRKG1/PLCB1/ADCY3/MAPK3/MYLK/PLA2G4A/ITPR2/ARHGEF1/KCNMA1/PLA2G2C	14
KEGG	hsa04971	Gastric acid secretion	8/848	76/8135	0.5439	0.8849	0.7724	GNAQ/GNAI2/CALM3/PLCB1/ADCY3/MYLK/ITPR2/HRH2	8
KEGG	hsa04966	Collecting duct acid secretion	3/848	27/8135	0.545	0.8849	0.7724	ATP6V1E2/ATP6V0A2/ATP6V0E1	3
KEGG	hsa01250	Biosynthesis of nucleotide sugars	4/848	37/8135	0.548	0.8855	0.7729	PGM1/GALK2/PMM1/HK2	4
KEGG	hsa04621	NOD-like receptor signaling pathway	19/848	184/8135	0.554	0.8905	0.7774	NLRP1/JUN/GABARAPL1/GABARAP/PLCB1/CXCL1/MAPK3/VDAC3/JAK1/ITPR2/MAPK13/TRPM2/OAS2/OAS3/MAP1LC3B2/DEFA4/BCL2L1/NLRP7/TAB3	19
KEGG	hsa05100	Bacterial invasion of epithelial cells	8/848	77/8135	0.5593	0.8905	0.7774	WASL/ARPC3/PIK3R1/CBL/WASF2/GAB1/ARPC2/CTNNA1	8
KEGG	hsa05140	Leishmaniasis	8/848	77/8135	0.5593	0.8905	0.7774	ITGA4/IRAK1/FOS/JUN/PTGS2/MAPK3/JAK1/MAPK13	8
KEGG	hsa05417	Lipid and atherosclerosis	22/848	215/8135	0.5709	0.8983	0.7841	ATF4/AKT2/MIB2/NFATC3/PIK3R1/IRAK1/FOS/JUN/CALM3/PLCB1/CXCL1/TNFRSF10B/MAP2K7/PPP3CA/MAPK3/CD14/AKT1/MAPK13/POU2F2/ARHGEF1/PDPK1/BCL2L1	22
KEGG	hsa00480	Glutathione metabolism	6/848	58/8135	0.5715	0.8983	0.7841	GSTA4/RRM2/GSTM1/GPX2/GGCT/MGST3	6
KEGG	hsa04612	Antigen processing and presentation	8/848	78/8135	0.5745	0.8983	0.7841	IFI30/NFYA/KIR2DL1/PSME3/KLRD1/CALR/KIR2DS4/HLA-G	8
KEGG	hsa03040	Spliceosome	15/848	147/8135	0.5756	0.8983	0.7841	DDX5/SNRPD3/SF3A3/SF3B1/SF3A1/SF3A2/TRA2A/DDX46/DDX39B/HNRNPA1L2/PRPF38B/RBM17/HNRNPC/PRPF38A/SNRPD2	15
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	10/848	98/8135	0.5779	0.8983	0.7841	GNAQ/PIK3R1/ALOX12/CALM3/PLCB1/ADCY3/PLA2G4A/ITPR2/MAPK13/HRH1	10
KEGG	hsa05410	Hypertrophic cardiomyopathy	9/848	90/8135	0.604	0.9302	0.812	ITGA4/TPM4/SLC8A1/CACNB4/SGCA/LMNA/PRKAA2/ATP2A1/CACNA2D1	9
KEGG	hsa00983	Drug metabolism - other enzymes	8/848	80/8135	0.6041	0.9302	0.812	GSTA4/RRM2/GSTM1/UPP1/MGST3/NAT1/CES1/TK1	8
KEGG	hsa05033	Nicotine addiction	4/848	40/8135	0.6115	0.9341	0.8154	GABRR2/GRIN3B/GABRB1/CHRNA7	4
KEGG	hsa00020	Citrate cycle (TCA cycle)	3/848	30/8135	0.6185	0.9341	0.8154	SUCLG2/IDH3B/MDH1	3
KEGG	hsa01523	Antifolate resistance	3/848	30/8135	0.6185	0.9341	0.8154	TYMS/ALOX12/FOLR3	3
KEGG	hsa00590	Arachidonic acid metabolism	6/848	61/8135	0.6221	0.9341	0.8154	ALOX12/GPX2/TBXAS1/PTGS2/PLA2G4A/PLA2G2C	6
KEGG	hsa04024	cAMP signaling pathway	22/848	221/8135	0.6248	0.9341	0.8154	AMH/AKT2/GRIN3B/PIK3R1/GNAI2/CREBBP/FOS/EP300/JUN/CRHR2/CALM3/PDE3B/ADCY3/MAPK3/AKT1/HCAR3/PLD1/RAC2/F2R/HTR1D/ATP2A1/ARAP3	22
KEGG	hsa05206	MicroRNAs in cancer	31/848	310/8135	0.6267	0.9341	0.8154	E2F1/RPTOR/MIR23A/DDIT4/MCL1/ABL1/PIK3R1/MIR27A/CREBBP/CDK6/EP300/CCNE1/APC2/E2F2/TNXB/NOTCH2/PTGS2/MAPK3/DNMT3A/SOS2/FSCN1/MTOR/SLC7A1/APC/PDGFRB/ZEB1/NOTCH1/HDAC5/THBS1/RPS6KA5/RASSF1	31
KEGG	hsa04145	Phagosome	15/848	152/8135	0.6293	0.9341	0.8154	TUBA1C/TUBB4B/TUBA1A/THBS3/COLEC11/SCARB1/RILP/CD14/ATP6V1E2/CALR/HLA-G/ATP6V0A2/SEC61G/THBS1/ATP6V0E1	15
KEGG	hsa05146	Amoebiasis	10/848	102/8135	0.63	0.9341	0.8154	GNAQ/PIK3R1/CD1D/PLCB1/CXCL1/CD14/ACTN4/GNAL/SERPINB10/COL4A1	10
KEGG	hsa00670	One carbon pool by folate	2/848	20/8135	0.6323	0.9341	0.8154	MTHFD2/TYMS	2
KEGG	hsa01240	Biosynthesis of cofactors	15/848	153/8135	0.6396	0.9387	0.8194	PDXK/AK8/MTHFD2/PPOX/ALDH3A2/IDO2/PHOSPHO2/AK4/CMPK2/PMM1/EARS2/SPR/HAAO/ALAD/VKORC1	15
KEGG	hsa00410	beta-Alanine metabolism	3/848	31/8135	0.6411	0.9387	0.8194	AOC3/ALDH3A2/AOC2	3
KEGG	hsa00190	Oxidative phosphorylation	13/848	134/8135	0.6508	0.9488	0.8282	NDUFS7/LHPP/NDUFV1/NDUFA4/ATP6V1E2/NDUFA10/NDUFA7/COX6C/ATP6V0A2/NDUFB7/ATP6V0E1/NDUFA12/NDUFS8	13
KEGG	hsa00770	Pantothenate and CoA biosynthesis	2/848	21/8135	0.6591	0.9566	0.835	VNN1/ALDH3A2	2
KEGG	hsa03320	PPAR signaling pathway	7/848	75/8135	0.6778	0.9645	0.8419	UBC/SCD/SLC27A4/SCP2/PDPK1/ACSBG2/SLC27A1	7
KEGG	hsa05414	Dilated cardiomyopathy	9/848	96/8135	0.6818	0.9645	0.8419	ITGA4/TPM4/SLC8A1/CACNB4/ADCY3/SGCA/LMNA/ATP2A1/CACNA2D1	9
KEGG	hsa00051	Fructose and mannose metabolism	3/848	33/8135	0.6835	0.9645	0.8419	PFKFB2/PMM1/HK2	3
KEGG	hsa04927	Cortisol synthesis and secretion	6/848	65/8135	0.684	0.9645	0.8419	ATF4/GNAQ/SCARB1/PLCB1/ADCY3/ITPR2	6
KEGG	hsa00900	Terpenoid backbone biosynthesis	2/848	22/8135	0.6844	0.9645	0.8419	PCYOX1/HMGCR	2
KEGG	hsa04911	Insulin secretion	8/848	86/8135	0.686	0.9645	0.8419	ATF4/GNAQ/PLCB1/ADCY3/STX1A/VAMP2/KCNMA1/RAB3A	8
KEGG	hsa04962	Vasopressin-regulated water reabsorption	4/848	44/8135	0.6871	0.9645	0.8419	ARHGDIB/ADCY3/VAMP2/DCTN1	4
KEGG	hsa00230	Purine metabolism	12/848	128/8135	0.6949	0.9645	0.8419	PAICS/AK8/PRPS1/NUDT5/RRM2/PDE3B/AMPD2/AK4/ADCY3/PGM1/DGUOK/APRT	12
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/848	11/8135	0.7023	0.9645	0.8419	VKORC1	1
KEGG	hsa03020	RNA polymerase	3/848	34/8135	0.7032	0.9645	0.8419	POLR2F/POLR2J3/POLR3E	3
KEGG	hsa02010	ABC transporters	4/848	45/8135	0.7043	0.9645	0.8419	ABCB10/ABCC9/ABCA4/ABCA7	4
KEGG	hsa04340	Hedgehog signaling pathway	5/848	56/8135	0.7078	0.9645	0.8419	SPOPL/KIF3A/MEGF8/HHATL/DHH	5
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/848	23/8135	0.7081	0.9645	0.8419	SLC25A10/MDH1	2
KEGG	hsa04512	ECM-receptor interaction	8/848	88/8135	0.7108	0.9645	0.8419	ITGA4/THBS3/VWF/TNXB/COL9A1/THBS1/AGRN/COL4A1	8
KEGG	hsa00010	Glycolysis / Gluconeogenesis	6/848	67/8135	0.7123	0.9645	0.8419	ALDH3A2/G6PC/PGM1/PKM/MINPP1/HK2	6
KEGG	hsa05020	Prion disease	26/848	273/8135	0.7189	0.9645	0.8419	ATF4/TUBA1C/TUBB4B/GRIN3B/PIK3R1/NDUFS7/TUBA1A/PSMD8/NDUFV1/PPP3CA/MAPK3/SLC25A5/VDAC3/SLC25A6/ITPR2/MAPK13/NOTCH1/NDUFA4/NDUFA10/PSMB7/RAC2/NDUFA7/COX6C/NDUFB7/NDUFA12/NDUFS8	26
KEGG	hsa04360	Axon guidance	17/848	182/8135	0.7212	0.9645	0.8419	EPHA1/ABL1/NFATC3/PIK3R1/GNAI2/MYL12A/LRIG2/SSH1/PPP3CA/MAPK3/EPHB1/PARD6B/BMP7/RAC2/PDPK1/SEMA6C/PLXNA2	17
KEGG	hsa05202	Transcriptional misregulation in cancer	18/848	193/8135	0.7276	0.9645	0.8419	DDX5/PBX3/JMJD1C/CDK9/IGF1R/BAIAP3/TFE3/CD14/RARA/CCNT1/BCL2A1/ZEB1/LDB1/CEBPB/DEFA4/BCL2L1/ERG/DDB2	18
KEGG	hsa04920	Adipocytokine signaling pathway	6/848	69/8135	0.7389	0.9645	0.8419	AKT2/G6PC/AKT1/MTOR/PRKAA2/ACSBG2	6
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	6/848	69/8135	0.7389	0.9645	0.8419	GSTA4/EPHX1/GSTM1/PTGS2/MGST3/NAT1	6
KEGG	hsa00350	Tyrosine metabolism	3/848	36/8135	0.7398	0.9645	0.8419	AOC3/FAH/AOC2	3
KEGG	hsa05205	Proteoglycans in cancer	19/848	205/8135	0.7414	0.9645	0.8419	DDX5/AKT2/PIK3R1/IGF1R/WNT2B/RPS6KB2/CBL/MSN/MAPK3/SOS2/AKT1/GAB1/MTOR/ITPR2/MAPK13/HBEGF/ARHGEF1/PDPK1/THBS1	19
KEGG	hsa05145	Toxoplasmosis	10/848	112/8135	0.7437	0.9645	0.8419	AKT2/IRAK1/GNAI2/IL10RB/MAPK3/AKT1/JAK1/MAPK13/PDPK1/BCL2L1	10
KEGG	hsa04972	Pancreatic secretion	9/848	102/8135	0.7495	0.9645	0.8419	GNAQ/PLCB1/ADCY3/ITPR2/KCNMA1/ATP2A1/PLA2G2C/CELA2B/CPB2	9
KEGG	hsa00592	alpha-Linolenic acid metabolism	2/848	25/8135	0.7511	0.9645	0.8419	PLA2G4A/PLA2G2C	2
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	3/848	37/8135	0.7568	0.9645	0.8419	PIK3R1/MAPK3/PDPK1	3
KEGG	hsa05216	Thyroid cancer	3/848	37/8135	0.7568	0.9645	0.8419	TPR/MAPK3/DDB2	3
KEGG	hsa05034	Alcoholism	17/848	187/8135	0.7611	0.9645	0.8419	ATF4/FOSB/GRIN3B/HDAC7/HDAC9/GNAI2/ADORA2B/CALM3/MAPK3/SOS2/GNGT2/GNB3/HDAC5/GNG2/GNG10/GNG5/GNB2	17
KEGG	hsa04978	Mineral absorption	5/848	60/8135	0.7637	0.9645	0.8419	MT2A/SLC8A1/TRPM6/ATP7B/MT1F	5
KEGG	hsa04146	Peroxisome	7/848	82/8135	0.7649	0.9645	0.8419	CRAT/AMACR/HACL1/SCP2/PXMP4/ACOT8/PHYH	7
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	4/848	49/8135	0.7661	0.9645	0.8419	PGM1/GALK2/PMM1/HK2	4
KEGG	hsa04672	Intestinal immune network for IgA production	4/848	49/8135	0.7661	0.9645	0.8419	ITGA4/MADCAM1/IL15RA/CCL28	4
KEGG	hsa04970	Salivary secretion	8/848	93/8135	0.7671	0.9645	0.8419	GNAQ/CALM3/PRKG1/PLCB1/ADCY3/ITPR2/VAMP2/KCNMA1	8
KEGG	hsa05323	Rheumatoid arthritis	8/848	93/8135	0.7671	0.9645	0.8419	ANGPT1/FOS/IL23A/JUN/CXCL1/ATP6V1E2/ATP6V0A2/ATP6V0E1	8
KEGG	hsa04064	NF-kappa B signaling pathway	9/848	104/8135	0.7698	0.9645	0.8419	MALT1/IRAK1/CXCL1/PTGS2/CD14/BCL2A1/LTA/BCL2L1/TAB3	9
KEGG	hsa00790	Folate biosynthesis	2/848	26/8135	0.7704	0.9645	0.8419	SPR/TPH2	2
KEGG	hsa04979	Cholesterol metabolism	4/848	50/8135	0.7799	0.965	0.8424	LCAT/SCARB1/NPC1/VDAC3	4
KEGG	hsa04613	Neutrophil extracellular trap formation	17/848	190/8135	0.7832	0.965	0.8424	C5AR1/AKT2/HDAC7/PIK3R1/HDAC9/HMGB1/VWF/PLCB1/MAPK3/SLC25A5/VDAC3/AKT1/SLC25A6/MTOR/MAPK13/RAC2/HDAC5	17
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/848	14/8135	0.7861	0.965	0.8424	B4GALT3	1
KEGG	hsa05171	Coronavirus disease - COVID-19	21/848	232/8135	0.7863	0.965	0.8424	C5AR1/PIK3R1/CFD/IRAK1/FOS/ISG15/JUN/VWF/MAPK3/JAK1/RPL23A/MAPK13/HBEGF/RPL10/OAS2/OAS3/C3AR1/RPS5/MX1/EIF2AK2/RPS23	21
KEGG	hsa04217	Necroptosis	14/848	159/8135	0.7865	0.965	0.8424	CHMP1B/STAT6/HMGB1/PGAM5/FAF1/TNFRSF10B/SLC25A5/VDAC3/JAK1/SLC25A6/PLA2G4A/USP21/EIF2AK2/STAT4	14
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/848	27/8135	0.7885	0.965	0.8424	B4GALT3/ABO	2
KEGG	hsa00270	Cysteine and methionine metabolism	4/848	51/8135	0.793	0.9669	0.8441	AHCY/MRI1/DNMT3A/MDH1	4
KEGG	hsa00650	Butanoate metabolism	2/848	28/8135	0.8052	0.9749	0.851	BDH1/HADH	2
KEGG	hsa04918	Thyroid hormone synthesis	6/848	75/8135	0.8078	0.9749	0.851	ATF4/GNAQ/GPX2/PLCB1/ADCY3/ITPR2	6
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/848	15/8135	0.8085	0.9749	0.851	GLB1	1
KEGG	hsa04260	Cardiac muscle contraction	7/848	87/8135	0.8158	0.9766	0.8525	SLC9A7/TPM4/SLC8A1/CACNB4/COX6C/ATP2A1/CACNA2D1	7
KEGG	hsa00591	Linoleic acid metabolism	2/848	29/8135	0.8208	0.9766	0.8525	PLA2G4A/PLA2G2C	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/848	29/8135	0.8208	0.9766	0.8525	WWTR1/RASSF1	2
KEGG	hsa05321	Inflammatory bowel disease	5/848	65/8135	0.8218	0.9766	0.8525	STAT6/IL23A/JUN/TBX21/STAT4	5
KEGG	hsa05332	Graft-versus-host disease	3/848	42/8135	0.8284	0.9775	0.8533	KIR2DL1/KLRD1/HLA-G	3
KEGG	hsa00430	Taurine and hypotaurine metabolism	1/848	16/8135	0.8285	0.9775	0.8533	FMO5	1
KEGG	hsa00860	Porphyrin metabolism	3/848	43/8135	0.8404	0.9802	0.8556	PPOX/EARS2/ALAD	3
KEGG	hsa04940	Type I diabetes mellitus	3/848	43/8135	0.8404	0.9802	0.8556	ICA1/LTA/HLA-G	3
KEGG	hsa04060	Cytokine-cytokine receptor interaction	26/848	295/8135	0.8464	0.9802	0.8556	AMH/INHBA/IL13RA1/IL24/IL5RA/INHBC/CX3CR1/ACVR1B/XCL1/IL10RB/IL23A/IL15RA/TNFRSF18/CCR2/CSF3R/RELT/XCL2/IFNL1/CXCL1/TNFRSF10B/TGFBR1/CCL28/CX3CL1/BMP7/LTA/GDF5	26
KEGG	hsa00910	Nitrogen metabolism	1/848	17/8135	0.8464	0.9802	0.8556	CA8	1
KEGG	hsa04710	Circadian rhythm	2/848	31/8135	0.8487	0.9802	0.8556	SKP1/PRKAA2	2
KEGG	hsa05310	Asthma	2/848	31/8135	0.8487	0.9802	0.8556	FCER1G/RNASE3	2
KEGG	hsa05134	Legionellosis	4/848	57/8135	0.859	0.9856	0.8604	RAB1B/CXCL1/VCP/CD14	4
KEGG	hsa04215	Apoptosis - multiple species	2/848	32/8135	0.8611	0.9856	0.8604	HTRA2/BCL2L1	2
KEGG	hsa00061	Fatty acid biosynthesis	1/848	18/8135	0.8624	0.9856	0.8604	ACSBG2	1
KEGG	hsa04622	RIG-I-like receptor signaling pathway	5/848	70/8135	0.8677	0.9882	0.8626	ISG15/RNF125/DDX3X/PIN1/MAPK13	5
KEGG	hsa03050	Proteasome	3/848	46/8135	0.872	0.9896	0.8639	PSMD8/PSME3/PSMB7	3
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/848	19/8135	0.8768	0.9917	0.8657	IDH3B	1
KEGG	hsa00620	Pyruvate metabolism	3/848	47/8135	0.8812	0.9932	0.867	ALDH3A2/MDH1/PKM	3
KEGG	hsa00561	Glycerolipid metabolism	4/848	61/8135	0.8923	1	0.8729	AGPAT1/ALDH3A2/MBOAT1/AGPAT2	4
KEGG	hsa04925	Aldosterone synthesis and secretion	7/848	98/8135	0.8973	1	0.8729	ATF4/GNAQ/CALM3/SCARB1/PLCB1/ADCY3/ITPR2	7
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	2/848	36/8135	0.9019	1	0.8729	SIRT2/SIRT3	2
KEGG	hsa04640	Hematopoietic cell lineage	7/848	99/8135	0.9029	1	0.8729	ITGA4/CD55/IL5RA/CD1D/CSF3R/CD14/CD59	7
KEGG	hsa01230	Biosynthesis of amino acids	5/848	75/8135	0.9033	1	0.8729	PRPS1/RPIA/IDH3B/PKM/ASL	5
KEGG	hsa00220	Arginine biosynthesis	1/848	22/8135	0.9115	1	0.8729	ASL	1
KEGG	hsa00340	Histidine metabolism	1/848	22/8135	0.9115	1	0.8729	ALDH3A2	1
KEGG	hsa04976	Bile secretion	6/848	89/8135	0.9135	1	0.8729	EPHX1/SCARB1/AQP8/ADCY3/SLC4A5/HMGCR	6
KEGG	hsa04514	Cell adhesion molecules	11/848	149/8135	0.919	1	0.8729	OCLN/ITGA4/CLDN6/MADCAM1/ICAM3/ALCAM/NFASC/HLA-G/NLGN3/CDH4/CLDN10	11
KEGG	hsa01200	Carbon metabolism	8/848	115/8135	0.923	1	0.8729	PRPS1/RPIA/H6PD/SUCLG2/IDH3B/MDH1/PKM/HK2	8
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	4/848	66/8135	0.924	1	0.8729	GATC/EARS2/IARS2/VARS2	4
KEGG	hsa00260	Glycine, serine and threonine metabolism	2/848	40/8135	0.9313	1	0.8729	AOC3/AOC2	2
KEGG	hsa00830	Retinol metabolism	4/848	68/8135	0.9342	1	0.8729	CYP27C1/LRAT/CYP26C1/RDH5	4
KEGG	hsa04216	Ferroptosis	2/848	41/8135	0.9372	1	0.8729	VDAC3/MAP1LC3B2	2
KEGG	hsa04950	Maturity onset diabetes of the young	1/848	26/8135	0.9431	1	0.8729	HNF1A	1
KEGG	hsa05150	Staphylococcus aureus infection	6/848	96/8135	0.9441	1	0.8729	C5AR1/CFD/KRT38/C3AR1/DEFA4/KRT23	6
KEGG	hsa00982	Drug metabolism - cytochrome P450	4/848	72/8135	0.9509	1	0.8729	GSTA4/GSTM1/MGST3/FMO5	4
KEGG	hsa04742	Taste transduction	5/848	86/8135	0.9535	1	0.8729	PLCB1/TAS2R60/GNB3/HTR1D/TAS1R3	5
KEGG	hsa04744	Phototransduction	1/848	29/8135	0.9592	1	0.8729	CALM3	1
KEGG	hsa00053	Ascorbate and aldarate metabolism	1/848	30/8135	0.9634	1	0.8729	ALDH3A2	1
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	1/848	30/8135	0.9634	1	0.8729	MDH1	1
KEGG	hsa00280	Valine, leucine and isoleucine degradation	2/848	48/8135	0.967	1	0.8729	ALDH3A2/HADH	2
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/848	78/8135	0.9687	1	0.8729	GSTA4/EPHX1/GSTM1/MGST3	4
KEGG	hsa00640	Propanoate metabolism	1/848	32/8135	0.9707	1	0.8729	SUCLG2	1
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	6/848	109/8135	0.9765	1	0.8729	REXO1/EIF6/NXF1/BMS1/NXF3/GNL3L	6
KEGG	hsa00040	Pentose and glucuronate interconversions	1/848	34/8135	0.9765	1	0.8729	DCXR	1
KEGG	hsa00512	Mucin type O-glycan biosynthesis	1/848	36/8135	0.9812	1	0.8729	GALNT2	1
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	1/848	37/8135	0.9831	1	0.8729	ASL	1
KEGG	hsa05330	Allograft rejection	1/848	38/8135	0.9849	1	0.8729	HLA-G	1
KEGG	hsa04623	Cytosolic DNA-sensing pathway	2/848	63/8135	0.9921	1	0.8729	POLR2F/POLR3E	2
KEGG	hsa04080	Neuroactive ligand-receptor interaction	24/848	353/8135	0.9936	1	0.8729	C5AR1/GABRR2/GRIN3B/CYSLTR2/P2RY10/CRHR2/ADORA2B/UCN/GRIK4/PATE2/MLNR/NR3C1/C3AR1/F2R/HTR1D/SSTR4/GABRB1/GRM2/HRH2/CHRNA7/GNRH2/HRH1/GLP2R/LTB4R2	24
KEGG	hsa00330	Arginine and proline metabolism	1/848	51/8135	0.9964	1	0.8729	ALDH3A2	1
KEGG	hsa05320	Autoimmune thyroid disease	1/848	53/8135	0.9971	1	0.8729	HLA-G	1
KEGG	hsa03010	Ribosome	7/848	158/8135	0.9982	1	0.8729	MRPL18/RPL23A/RPL10/MRPL4/RPS5/RPS23/MRPL36	7
KEGG	hsa00140	Steroid hormone biosynthesis	1/848	61/8135	0.9988	1	0.8729	HSD17B7	1
KEGG	hsa05322	Systemic lupus erythematosus	2/848	136/8135	1	1	0.8729	SNRPD3/ACTN4	2
KEGG	hsa04740	Olfactory transduction	7/848	440/8135	1	1	0.8729	OR11A1/CALM3/SLC8A1/PRKG1/RGS2/ADCY3/GNAL	7