ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa03010	Ribosome	85/1360	158/8135	5.592e-27	1.862e-24	1.695e-24	MRPL2/MRPL21/MRPL14/MRPS12/MRPS2/MRPS7/MRPL36/MRPS11/MRPL24/MRPL20/MRPS18A/MRPS15/RPS29/RPL27A/RPS7/FAU/RPL27/MRPL17/MRPL16/MRPS16/RPL19/RPS21/MRPL18/RPS10/UBA52/MRPL11/RPS8/RPS11/RPL35/MRPL10/RPS14/MRPL9/RPL37A/MRPL4/RPL24/RPL18A/RPS20/RPS16/RPL18/RPL15/MRPS9/MRPL34/RPL37/MRPL23/RPL38/RPLP1/RPL13A/RPLP2/RPS18/RPL32/RPL41/RPS28/RPL14/RPL7A/RPS15/RPS9/MRPL22/RPS12/RPL8/RPL11/RPL26/RPL10A/RPL6/RPS13/RPS2/RPS3/RPL28/RPS19/RPL29/RPL3/RPL35A/MRPL27/RPL10/MRPL13/RPS25/RPL36/RPS15A/RPLP0/MRPL12/MRPS17/MRPL3/MRPS5/RPSA/RPL23A/RPL31	85
KEGG	hsa05012	Parkinson disease	88/1360	266/8135	2.43e-11	4.047e-09	3.684e-09	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/ADRM1/TXN2/COX5A/CYC1/PSMC3/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/PSMB6/TRAP1/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/PSMC5/NDUFC1/NDUFB2/UBE2J2/UQCRFS1/PSMA7/TUBB4A/NDUFA3/UQCRQ/UQCR10/SLC25A5/UBA52/SLC18A2/NDUFB4/SLC25A6/PSMD11/PSMD3/PSMD8/XBP1/COX8A/TUBB2B/NDUFS4/UBE2L3/NDUFA11/SLC18A1/PSMC4/SDHA/TUBB/PSMB4/COX6C/COX5B/UBA7/PSMC2/PSMB1/UBE2G2/SLC39A13/PSMB7/PARK7/COX6B1/PSMD7/DDIT3/SLC39A11/PSMD13/PRKACA/NDUFA10/BAX/SOD1/PSMB2/SLC39A3/GNAL/NDUFA4/NDUFA12/MAOA/TUBB2A/KLC4/UQCRH/NDUFB5/NDUFA13/PSMD14/VDAC2/VDAC1/COX7C/GNAI2/CALML6	88
KEGG	hsa05016	Huntington disease	96/1360	306/8135	8.709e-11	9.667e-09	8.8e-09	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/ADRM1/COX5A/CYC1/POLR2F/DCTN3/PSMC3/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/PSMB6/AP2S1/UQCRC1/COX4I1/NDUFA9/NDUFV3/CLTA/NDUFB11/PSMC5/NDUFC1/ATG14/CREB3/NDUFB2/POLR2E/UQCRFS1/PSMA7/TUBB4A/NDUFA3/UQCRQ/UQCR10/MAP2K7/SLC25A5/POLR2I/NDUFB4/SLC25A6/PSMD11/PSMD3/TRAF2/PLCB1/PSMD8/ACTR1B/COX8A/TUBB2B/BBC3/NDUFS4/CLTB/NDUFA11/DLG4/POLR2D/PSMC4/PLCB3/POLR2L/SDHA/TUBB/PSMB4/COX6C/TBP/COX5B/TFAM/PSMC2/PSMB1/AP2A1/PSMB7/COX6B1/PSMD7/PSMD13/NDUFA10/AP2M1/BAX/SOD1/PSMB2/GPX3/NDUFA4/NDUFA12/TUBB2A/AP2A2/KLC4/UQCRH/DNAH8/NDUFB5/NDUFA13/NRF1/PSMD14/VDAC2/VDAC1/COX7C/TBPL1/SLC1A3	96
KEGG	hsa04932	Non-alcoholic fatty liver disease	54/1360	155/8135	2.586e-08	2.153e-06	1.96e-06	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/COX5A/CYC1/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/NDUFC1/NDUFB2/UQCRFS1/NDUFA3/UQCRQ/UQCR10/TNF/NDUFB4/TRAF2/TGFB1/XBP1/COX8A/NDUFS4/NDUFA11/NR1H3/SDHA/COX6C/COX5B/IRS1/COX6B1/DDIT3/CYP2E1/NDUFA10/BAX/NDUFA4/NDUFA12/UQCRH/NDUFB5/NDUFA13/PRKAG3/RELA/COX7C/AKT1/GSK3A/ADIPOR2	54
KEGG	hsa05171	Coronavirus disease - COVID-19	70/1360	232/8135	1.862e-07	1.24e-05	1.129e-05	C3AR1/RPS29/RPL27A/RPS7/FAU/RPL27/RPL19/RPS21/TNF/RPS10/UBA52/RPS8/RPS11/RPL35/RPS14/RPL37A/RPL24/RPL18A/RPS20/IL12A/RPS16/RPL18/RPL15/TLR4/RPL37/RPL38/RPLP1/RPL13A/RPLP2/RPS18/RPL32/RPL41/RPS28/RPL14/RPL7A/RPS15/RPS9/RPS12/TLR2/RPL8/RPL11/RPL26/RPL10A/RPL6/RPS13/RPS2/RPS3/RPL28/RPS19/VWF/RPL29/PRKCG/RPL3/RPL35A/RPL10/MX2/RPS25/RPL36/RPS15A/RPLP0/F13A1/MMP1/EIF2AK2/RELA/IRAK1/NFKBIB/RPSA/MX1/RPL23A/RPL31	70
KEGG	hsa03040	Spliceosome	48/1360	147/8135	1.363e-06	7.566e-05	6.888e-05	CCDC12/SNRPC/ALYREF/LSM4/SNRPA/SF3B5/PQBP1/SF3A2/BUD31/SNRPB/PRPF31/SNRPF/PUF60/RP9/SNRNP70/SNRPD2/PPIH/PRPF6/XAB2/CWC15/CTNNBL1/LSM7/TXNL4A/RBM17/U2AF2/PRPF19/BCAS2/SF3B4/HNRNPM/SF3B2/SF3A3/MAGOH/USP39/RNU4-2/SNRNP40/PHF5A/LSM2/SNRPA1/SRSF2/DDX23/PRPF4/SRSF9/WBP11/DHX38/PPIE/SNRPD1/EFTUD2/RNU4-1	48
KEGG	hsa05020	Prion disease	76/1360	273/8135	1.917e-06	8.163e-05	7.432e-05	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/ADRM1/COX5A/CYC1/PSMC3/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/PSMB6/UQCRC1/COX4I1/NDUFA9/NDUFV3/CSNK2B/NDUFB11/PSMC5/NDUFC1/CREB3/NDUFB2/UQCRFS1/PSMA7/TUBB4A/NDUFA3/UQCRQ/UQCR10/TNF/SLC25A5/NDUFB4/SLC25A6/PSMD11/PSMD3/STIP1/PSMD8/COX8A/TUBB2B/NDUFS4/NDUFA11/PSMC4/SDHA/TUBB/PSMB4/COX6C/COX5B/PSMC2/PSMB1/PSMB7/COX6B1/PSMD7/DDIT3/FYN/PSMD13/PRKACA/NDUFA10/BAX/LAMC1/SOD1/PSMB2/NDUFA4/NDUFA12/TUBB2A/KLC4/UQCRH/NDUFB5/NDUFA13/PSMD14/VDAC2/VDAC1/COX7C	76
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	65/1360	223/8135	1.961e-06	8.163e-05	7.432e-05	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/EPHX1/COX5A/CYC1/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/PLD2/UQCRC1/CBR1/COX4I1/NDUFA9/NDUFV3/NDUFB11/NDUFC1/NDUFB2/UQCRFS1/NDUFA3/UQCRQ/HMOX1/UQCR10/MAP2K7/SLC25A5/NDUFB4/SLC25A6/COX8A/NDUFS4/NDUFA11/EGF/SDHA/AKR1A1/HRAS/COX6C/COX5B/COX6B1/EPHX3/CYP2E1/NDUFA10/SOD1/MGST2/NDUFA4/NDUFA12/ARAF/UQCRH/NDUFB5/PTEN/NDUFA13/VDAC2/VDAC1/RELA/COX7C/MAP3K14/CYP1B1/AKR1C1/AKT1/AKR1C3/HGF	65
KEGG	hsa00190	Oxidative phosphorylation	44/1360	134/8135	3.158e-06	0.0001168	0.0001064	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/COX5A/CYC1/LHPP/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/NDUFC1/NDUFB2/UQCRFS1/NDUFA3/UQCRQ/UQCR10/NDUFB4/ATP6V1F/COX8A/NDUFS4/NDUFA11/SDHA/COX6C/COX5B/COX6B1/COX10/NDUFA10/NDUFA4/NDUFA12/UQCRH/NDUFB5/NDUFA13/COX7C/PPA1	44
KEGG	hsa04714	Thermogenesis	66/1360	232/8135	4.11e-06	0.0001237	0.0001126	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/COX5A/CYC1/NDUFS8/SMARCB1/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/COX14/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/NDUFC1/CREB3/NDUFB2/UQCRFS1/NDUFA3/UQCRQ/UQCR10/NDUFB4/SMARCA4/RPS6KB2/MLST8/AKT1S1/NDUFAF4/SIRT6/COX8A/COA5/NDUFS4/NDUFA11/COA4/ACTG1/SDHA/HRAS/COX6C/NDUFAF2/COX5B/COX6B1/COX10/COX20/PRKACA/NDUFA10/NDUFA4/NDUFA12/TSC2/SMARCD2/UQCRH/SMARCE1/NDUFB5/COA6/NDUFA13/PRKAG3/COX7C/NDUFAF6/SMARCD1/ACTB/ACSL1	66
KEGG	hsa05014	Amyotrophic lateral sclerosis	94/1360	364/8135	4.352e-06	0.0001237	0.0001126	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/ADRM1/NXT1/COX5A/CYC1/DCTN3/PSMC3/ALYREF/NDUFS8/CHCHD10/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/TOMM40/PSMB6/NUP93/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/PSMC5/NDUFC1/ATG14/NUP62/NDUFB2/UQCRFS1/PSMA7/TUBB4A/RAE1/NDUFA3/PFN1/UQCRQ/UQCR10/TNF/NDUFB4/PSMD11/PSMD3/TRAF2/PSMD8/UBQLN4/XBP1/ACTR1B/COX8A/TUBB2B/NEFH/NDUFS4/NDUFA11/NUP85/PSMC4/ACTG1/SEC13/SDHA/TUBB/PSMB4/COX6C/COX5B/HDAC6/SIGMAR1/PSMC2/PSMB1/CCS/PSMB7/COX6B1/PSMD7/DDIT3/SQSTM1/PSMD13/NDUFA10/BAX/SOD1/PSMB2/ATXN2L/GPX3/NDUFA4/NDUFA12/TUBB2A/KLC4/UQCRH/DNAH8/NDUFB5/NDUFA13/PSMD14/VDAC1/COX7C/BCL2/ACTB	94
KEGG	hsa03410	Base excision repair	17/1360	33/8135	4.458e-06	0.0001237	0.0001126	POLE4/MPG/XRCC1/FEN1/APEX2/NTHL1/POLD2/NEIL1/APEX1/NEIL3/MUTYH/LIG1/POLE3/POLL/POLD4/SMUG1/PARP3	17
KEGG	hsa05415	Diabetic cardiomyopathy	59/1360	203/8135	6.417e-06	0.0001644	0.0001496	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/COX5A/CYC1/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/UQCRC1/COX4I1/NDUFA9/NDUFV3/NDUFB11/NDUFC1/NDUFB2/UQCRFS1/NDUFA3/UQCRQ/UQCR10/SLC25A5/NDUFB4/SLC25A6/PLCB1/TGFB1/PPP1CA/COX8A/NDUFS4/NDUFA11/PLCB3/PDHA1/GYS1/GFPT2/SDHA/COX6C/COX5B/PDK2/IRS1/COX6B1/PRKCG/NDUFA10/MPC1/NDUFA4/NDUFA12/UQCRH/NDUFB5/PTEN/NDUFA13/VDAC2/VDAC1/RELA/COX7C/AKT1/AGER	59
KEGG	hsa05010	Alzheimer disease	94/1360	384/8135	4.402e-05	0.001047	0.0009532	NDUFS3/NDUFB10/NDUFV1/HSD17B10/NDUFS6/NDUFB9/ADRM1/COX5A/CYC1/PSMC3/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/PSMB6/UQCRC1/COX4I1/NDUFA9/NDUFV3/CSNK2B/CSNK1E/NDUFB11/PSMC5/NDUFC1/ATG14/NDUFB2/UQCRFS1/PSMA7/TUBB4A/NDUFA3/UQCRQ/UQCR10/MAP2K7/TNF/SLC25A5/NDUFB4/SLC25A6/PSMD11/PSMD3/TRAF2/PLCB1/PSMD8/XBP1/COX8A/TUBB2B/NDUFS4/NDUFA11/PSMC4/PLCB3/DVL2/SDHA/TUBB/PSMB4/HRAS/COX6C/COX5B/PSMC2/PSMB1/CDK5/SLC39A13/PSMB7/WNT10B/IRS1/COX6B1/PSMD7/DDIT3/SLC39A11/PSMD13/NDUFA10/PSMB2/SLC39A3/NDUFA4/NDUFA12/DVL1/TUBB2A/ARAF/KLC4/UQCRH/NDUFB5/PSENEN/FZD8/EIF2AK2/NDUFA13/PSMD14/VDAC2/VDAC1/RELA/COX7C/CALML6/AKT1/AGER	94
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	35/1360	109/8135	5.336e-05	0.001185	0.001078	POP7/NXT1/NHP2/IMP4/TBL3/NOB1/CSNK2B/IMP3/RRP7A/TCOF1/SBDS/GNL2/MPHOSPH10/RPP38/RIOK1/RPP30/RIOK2/UTP15/PWP2/POP4/GTPBP4/RAN/UTP18/FBL/NAT10/RPP25L/EIF6/GAR1/WDR43/RPP40/NOL6/NMD3/RPP25/NOP56/DKC1	35
KEGG	hsa03050	Proteasome	19/1360	46/8135	6.653e-05	0.001385	0.001261	ADRM1/PSMC3/PSMB6/PSMC5/PSMA7/PSMD11/PSMD3/PSMD8/PSMC4/PSMF1/PSMB4/PSMC2/PSMB1/PSMB7/PSMD7/PSMD13/PSMB10/PSMB2/PSMD14	19
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	109/1360	476/8135	0.0002077	0.004068	0.003703	NDUFS3/NDUFB10/NDUFV1/HSD17B10/NDUFS6/NDUFB9/ADRM1/COX5A/CYC1/DCTN3/PSMC3/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/TOMM40/PSMB6/TRAP1/UQCRC1/COX4I1/NDUFA9/NDUFV3/CSNK2B/CSNK1E/NDUFB11/PSMC5/NDUFC1/ATG14/NDUFB2/UBE2J2/UQCRFS1/PSMA7/TUBB4A/NDUFA3/UQCRQ/UQCR10/MAP2K7/TNF/SLC25A5/UBA52/NDUFB4/SLC25A6/PSMD11/PSMD3/TRAF2/PLCB1/PSMD8/XBP1/ACTR1B/COX8A/TUBB2B/NEFH/NDUFS4/UBE2L3/NDUFA11/DLG4/PSMC4/PLCB3/DVL2/SDHA/TUBB/PSMB4/HRAS/COX6C/COX5B/UBA7/SIGMAR1/PSMC2/PSMB1/CCS/CDK5/UBE2G2/PSMB7/WNT10B/PARK7/COX6B1/PSMD7/DDIT3/SQSTM1/PRKCG/PSMD13/NDUFA10/BAX/SOD1/PSMB2/ATXN2L/GPX3/NDUFA4/NDUFA12/DVL1/TUBB2A/ARAF/KLC4/UQCRH/DNAH8/NDUFB5/FZD8/NDUFA13/PSMD14/VDAC2/VDAC1/RELA/COX7C/CALML6/BCL2/AGER	109
KEGG	hsa03030	DNA replication	15/1360	36/8135	0.0003452	0.006386	0.005814	POLE4/MCM5/FEN1/MCM7/POLD2/RNASEH2A/LIG1/POLE3/POLA2/POLD4/RNASEH2C/RNASEH2B/PRIM1/RFC4/RPA1	15
KEGG	hsa01200	Carbon metabolism	34/1360	115/8135	0.0004013	0.007034	0.006404	ECHS1/MDH2/IDH3G/IDH3A/PGP/IDH3B/IDH2/SDSL/GPI/PGLS/GOT2/PDHA1/ME1/DLAT/SDHA/GLYCTK/SHMT2/ME3/AMT/PC/ENO3/PKM/PCCB/ADH5/FBP1/ACOX3/ACSS1/PFKL/GOT1/GCK/FH/RPIA/DLST/ADPGK	34
KEGG	hsa04141	Protein processing in endoplasmic reticulum	46/1360	171/8135	0.0004692	0.007813	0.007113	RNF5/RAD23A/UBE2J2/STUB1/P4HB/CALR/MAN1B1/MAP2K7/HSP90AB1/SSR4/UBXN1/NPLOC4/DNAJC1/TRAF2/MOGS/UBQLN4/XBP1/SEC61B/SIL1/PRKCSH/ERP29/SEC13/SYVN1/BAG1/UBXN8/PDIA4/UBXN6/HSPBP1/UBE2G2/SEC61A1/DDIT3/UBE2D4/HERPUD1/BAX/SSR3/BCAP31/DNAJC5B/HYOU1/SSR2/SEC24C/RPN2/EIF2AK2/AMFR/CUL1/BCL2/CANX	46
KEGG	hsa03020	RNA polymerase	14/1360	34/8135	0.0006258	0.009924	0.009034	POLR2F/ZNRD1/POLR2E/POLR1D/POLR2I/POLR3E/POLR1C/POLR2D/POLR3F/POLR2L/POLR3B/POLR3K/CD3EAP/TWISTNB	14
KEGG	hsa03250	Viral life cycle - HIV-1	21/1360	63/8135	0.0009355	0.01416	0.01289	NELFA/NELFE/KAT2A/FEZ1/SMARCB1/MAP1A/NELFCD/PIN1/VPS4A/APOBEC3G/CD4/RAN/SUPT5H/NELFB/CHMP6/CDK9/HGS/MX2/APOBEC3D/CPSF6/MX1	21
KEGG	hsa00620	Pyruvate metabolism	17/1360	47/8135	0.001005	0.01455	0.01325	MDH2/ALDH2/HAGH/PDHA1/ME1/DLAT/PCK2/AKR1A1/ME3/PC/PKM/ADH5/ACSS1/GRHPR/ACYP1/ALDH1B1/FH	17
KEGG	hsa01240	Biosynthesis of cofactors	40/1360	153/8135	0.001918	0.02661	0.02423	GMPPA/FLAD1/DHRS3/UROD/ALDH2/FECH/BCAT2/AFMID/NADSYN1/PMM1/UROS/GSS/HMBS/ALPL/PPOX/SPR/FPGS/HPD/VKORC1/AKR1A1/PPCS/SHMT2/ADSL/OXSM/HAAO/GCH1/PDXK/NME3/COX10/MPI/GUSB/AK2/MMAB/MTHFD1/CMPK2/HSD17B6/ALDH1B1/PPCDC/COQ5/NME1	40
KEGG	hsa00020	Citrate cycle (TCA cycle)	12/1360	30/8135	0.002047	0.02726	0.02482	MDH2/IDH3G/IDH3A/IDH3B/IDH2/PDHA1/DLAT/SDHA/PCK2/PC/FH/DLST	12
KEGG	hsa01232	Nucleotide metabolism	25/1360	85/8135	0.002429	0.03111	0.02832	DTYMK/ITPA/ADA/AMPD2/UPP1/DCTPP1/DGUOK/ENTPD6/UCKL1/APRT/NT5C/GUK1/ADSL/GMPS/NT5C3B/DCTD/NME3/UCK1/ASMTL/AK2/UCK2/CMPK2/NME1/ENTPD1/UPP2	25
KEGG	hsa03420	Nucleotide excision repair	16/1360	47/8135	0.002887	0.0356	0.03241	POLE4/RAD23A/ERCC2/ERCC1/POLD2/ERCC3/XPA/LIG1/POLE3/MNAT1/POLD4/DDB2/DDB1/CUL4A/RFC4/RPA1	16
KEGG	hsa00240	Pyrimidine metabolism	18/1360	58/8135	0.005061	0.06019	0.05479	DTYMK/NUDT2/UPP1/DCTPP1/ENTPD6/UCKL1/NT5C/NT5C3B/DCTD/NME3/UCK1/ASMTL/UCK2/CMPK2/DPYS/NME1/ENTPD1/UPP2	18
KEGG	hsa00790	Folate biosynthesis	10/1360	26/8135	0.006632	0.07615	0.06932	QDPR/CBR1/ALPL/AKR1B1/SPR/FPGS/GCH1/MOCOS/PCBD1/AKR1C3	10
KEGG	hsa00280	Valine, leucine and isoleucine degradation	15/1360	48/8135	0.009392	0.1042	0.0949	HSD17B10/ECHS1/ALDH2/BCAT2/HMGCL/ACAA2/HADHA/BCKDHB/PCCB/ACADSB/ACSF3/MCCC2/ACAD8/ALDH1B1/IL4I1	15
KEGG	hsa04640	Hematopoietic cell lineage	26/1360	99/8135	0.01039	0.1113	0.1013	CR1/HLA-DMA/CD1D/ITGA2/IL4R/HLA-DPB1/CD33/GP5/TNF/HLA-DMB/CD1C/CD8B/HLA-DPA1/CD8A/ITGA1/ITGB3/CD4/CD3E/CD37/CR1L/IL1R2/FCGR1A/HLA-DRA/CD59/CSF1R/CD5	26
KEGG	hsa05017	Spinocerebellar ataxia	35/1360	143/8135	0.01069	0.1113	0.1013	ADRM1/PSMC3/PSMB6/PSMC5/ATG14/PSMA7/SLC25A5/SLC25A6/PSMD11/PSMD3/TRAF2/PLCB1/PSMD8/XBP1/PSMC4/PLCB3/ATXN10/KAT5/PSMB4/TBP/PSMC2/PSMB1/PSMB7/PSMD7/PRKCG/PSMD13/PSMB2/ATXN2L/AFG3L2/PSMD14/VDAC2/VDAC1/TBPL1/NOP56/AKT1	35
KEGG	hsa04146	Peroxisome	22/1360	82/8135	0.01364	0.1346	0.1226	ECH1/PEX14/MPV17L2/DHRS4/IDH2/PHYH/PEX10/PXMP4/HMGCL/MPV17/MVK/PEX16/PEX5/DECR2/ACOX3/PMVK/ABCD4/SOD1/SLC25A17/CROT/PEX7/ACSL1	22
KEGG	hsa00510	N-Glycan biosynthesis	15/1360	50/8135	0.01395	0.1346	0.1226	DOLK/ALG2/DPM3/B4GALT3/MAN1B1/ALG3/SRD5A3/MOGS/ALG1/DOLPP1/DPM2/RPN2/ALG12/MGAT3/ALG8	15
KEGG	hsa01250	Biosynthesis of nucleotide sugars	12/1360	37/8135	0.01415	0.1346	0.1226	TSTA3/GMPPA/PMM1/GMDS/GPI/GFPT2/GALE/TGDS/UAP1/MPI/GCK/GALT	12
KEGG	hsa05321	Inflammatory bowel disease	18/1360	65/8135	0.01764	0.1632	0.1486	GATA3/HLA-DMA/IL4R/HLA-DPB1/TLR5/TNF/HLA-DMB/HLA-DPA1/TGFB1/TBX21/IL12A/TLR4/TLR2/IL18R1/HLA-DRA/IL18/IL21R/RELA	18
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	49/1360	222/8135	0.02159	0.1943	0.1769	KAT2A/CCNA1/ANAPC11/HLA-DMA/CREB3/HLA-DPB1/CHEK2/CALR/RANBP1/TNF/SLC25A5/HLA-DMB/ANAPC2/SLC25A6/RANBP3/HLA-DPA1/TGFB1/CD4/CD3E/RAN/KAT5/MAD1L1/HRAS/TBP/CRTC2/BUB3/EGR2/CDK4/FDPS/TERT/CDKN2B/IL1R2/CCND1/CRTC1/ANAPC15/HLA-F/HLA-DRA/PRKACA/BAX/E2F1/GPS2/PTEN/VDAC2/VDAC1/RELA/MAP3K14/TBPL1/AKT1/CANX	49
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	14/1360	49/8135	0.02625	0.23	0.2094	TSTA3/GMPPA/PMM1/HEXA/GMDS/GPI/GFPT2/GALE/UAP1/MPI/GCK/GALT/CHIT1/CYB5R3	14
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	7/1360	19/8135	0.02836	0.2421	0.2204	IDH3G/IDH3A/IDH3B/BCAT2/IDH2/GOT2/GOT1	7
KEGG	hsa00360	Phenylalanine metabolism	6/1360	16/8135	0.03815	0.3036	0.2764	MIF/GOT2/HPD/MAOA/GOT1/IL4I1	6
KEGG	hsa00051	Fructose and mannose metabolism	10/1360	33/8135	0.03829	0.3036	0.2764	TSTA3/GMPPA/PMM1/GMDS/AKR1B1/PFKFB2/MPI/FBP1/PFKL/KHK	10
KEGG	hsa04130	SNARE interactions in vesicular transport	10/1360	33/8135	0.03829	0.3036	0.2764	BNIP1/VAMP2/VAMP8/STX8/STX4/STX18/VAMP1/YKT6/USE1/BET1L	10
KEGG	hsa00071	Fatty acid degradation	12/1360	43/8135	0.04501	0.3405	0.31	ECHS1/ACADVL/ALDH2/ECI1/ACAA2/HADHA/GCDH/ADH5/ACOX3/ACADSB/ALDH1B1/ACSL1	12
KEGG	hsa00860	Porphyrin metabolism	12/1360	43/8135	0.04501	0.3405	0.31	UROD/FECH/HMOX1/UROS/HMBS/PPOX/HMOX2/BLVRB/COX10/GUSB/MMAB/FXN	12
KEGG	hsa04723	Retrograde endocannabinoid signaling	33/1360	148/8135	0.04601	0.3405	0.31	NDUFS3/NDUFB10/NDUFV1/NDUFS6/NDUFB9/NDUFS8/NDUFAB1/NDUFB7/NDUFB8/NDUFS7/NDUFA6/NDUFA2/NDUFA9/NDUFV3/NDUFB11/NDUFC1/NDUFB2/NDUFA3/NDUFB4/PLCB1/NDUFS4/NDUFA11/GNGT2/PLCB3/FAAH/PRKCG/PRKACA/NDUFA10/NDUFA4/NDUFA12/NDUFB5/NDUFA13/GNAI2	33
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1360	30/8135	0.0511	0.3699	0.3368	MDH2/PGP/AFMID/GLYCTK/SHMT2/AMT/PCCB/ACSS1/GRHPR	9
KEGG	hsa00900	Terpenoid backbone biosynthesis	7/1360	22/8135	0.0611	0.4312	0.3925	RCE1/MVD/MVK/FDPS/PMVK/DHDDS/PDSS2	7
KEGG	hsa05144	Malaria	13/1360	50/8135	0.06336	0.4312	0.3925	THBS1/CR1/CD81/TNF/TGFB1/IL12A/TLR4/SDC1/CR1L/TLR2/CD40LG/IL18/HGF	13
KEGG	hsa00061	Fatty acid biosynthesis	6/1360	18/8135	0.06588	0.4312	0.3925	OLAH/HSD17B8/OXSM/ACSF3/MECR/ACSL1	6
KEGG	hsa00350	Tyrosine metabolism	10/1360	36/8135	0.06591	0.4312	0.3925	MIF/LRTOMT/COMT/GOT2/HPD/ADH5/MAOA/GOT1/GSTZ1/IL4I1	10
KEGG	hsa04120	Ubiquitin mediated proteolysis	31/1360	142/8135	0.06604	0.4312	0.3925	SAE1/UBE2E2/RHOBTB1/UBE2I/ANAPC11/RNF7/UBE2J2/STUB1/PIAS4/UBE2O/UBE2M/UBA52/ANAPC2/FBXO4/UBE2L3/PRPF19/SOCS1/SYVN1/UBA7/UBE2G2/UBOX5/UBE2D4/ANAPC15/PPIL2/FZR1/DDB2/DDB1/FBXW8/SKP2/CUL4A/CUL1	31
KEGG	hsa00330	Arginine and proline metabolism	13/1360	51/8135	0.07258	0.4573	0.4163	SAT2/ALDH2/SRM/GOT2/GATM/ARG1/CKB/P4HA2/MAOA/GOT1/ALDH1B1/CNDP2/CARNS1	13
KEGG	hsa05169	Epstein-Barr virus infection	42/1360	202/8135	0.07279	0.4573	0.4163	ADRM1/PSMC3/CCNA1/HLA-DMA/PSMC5/HLA-DPB1/CALR/MAP2K7/TNF/HLA-DMB/PSMD11/PSMD3/HLA-DPA1/TRAF2/PSMD8/CDKN1B/TAB1/NFKBIE/PSMC4/CD3E/TLR2/CDK4/PSMC2/PSMD7/CCND1/RUNX3/HLA-F/HLA-DRA/PSMD13/BAX/E2F1/DDB2/EIF2AK2/PSMD14/SKP2/RELA/MAP3K14/IRAK1/NFKBIB/ENTPD1/AKT1/BCL2	42
KEGG	hsa00380	Tryptophan metabolism	11/1360	42/8135	0.07992	0.4856	0.4421	ECHS1/ALDH2/AFMID/HADHA/GCDH/HAAO/MAOA/ALDH1B1/CYP1B1/DLST/IL4I1	11
KEGG	hsa05140	Leishmaniasis	18/1360	77/8135	0.08184	0.4856	0.4421	CR1/HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/TGFB1/TAB1/IL12A/TLR4/CR1L/TLR2/FCGR1A/HLA-DRA/RELA/IRAK1/EEF1A1/NFKBIB	18
KEGG	hsa00010	Glycolysis / Gluconeogenesis	16/1360	67/8135	0.083	0.4856	0.4421	ALDH2/G6PC3/GPI/PDHA1/DLAT/PCK2/AKR1A1/ENO3/PKM/ADH5/FBP1/ACSS1/PFKL/GCK/ALDH1B1/ADPGK	16
KEGG	hsa05134	Legionellosis	14/1360	57/8135	0.08312	0.4856	0.4421	CR1/TLR5/TNF/IL12A/TLR4/HSF1/CR1L/TLR2/ARF1/IL18/BCL2L13/NAIP/RELA/EEF1A1	14
KEGG	hsa00310	Lysine degradation	15/1360	63/8135	0.09313	0.5278	0.4805	SUV39H1/ECHS1/ALDH2/EHMT2/HADHA/GCDH/EHMT1/PLOD2/PLOD3/KMT2D/ALDH1B1/KMT2C/PRDM7/DLST/SMYD3	15
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1360	53/8135	0.09351	0.5278	0.4805	AP2S1/CLTA/PLCB1/CLTB/PLCB3/ATP1A4/AP2A1/PRKCG/PRKACA/AP2M1/AP2A2/ATP1A3/DNM3	13
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1360	20/8135	0.1028	0.566	0.5153	B4GALT7/B3GAT3/CHST14/XYLT2/B3GALT6/CHST12	6
KEGG	hsa04962	Vasopressin-regulated water reabsorption	11/1360	44/8135	0.105	0.566	0.5153	VAMP2/ARHGDIA/CREB3/RAB11B/STX4/DYNC2LI1/DYNLL1/PRKACA/DYNC1LI1/AVPR2/AVP	11
KEGG	hsa05030	Cocaine addiction	12/1360	49/8135	0.1054	0.566	0.5153	CREB3/SLC18A2/RGS9/DLG4/SLC18A1/CDK5/GPSM1/PRKACA/MAOA/GRM2/RELA/GNAI2	12
KEGG	hsa05132	Salmonella infection	49/1360	249/8135	0.1191	0.6298	0.5733	TXN2/VPS16/DCTN3/ARPC5L/ANXA2/TUBB4A/TLR5/PFN1/RHOB/MAP2K7/TNF/CYTH2/HSP90AB1/TRAF2/CYTH3/ACTR1B/TAB1/TUBB2B/TLR4/PKN1/ACTG1/RRAS/ARF6/ARPC1A/FHOD1/TUBB/DYNLT1/HRAS/TLR2/ARF1/DYNC2LI1/CASP5/RPS3/DYNLL1/BAX/SNX33/IL18/TUBB2A/KLC4/DYNC1LI1/NAIP/RAB9A/BRK1/RELA/IRAK1/VPS11/AKT1/BCL2/ACTB	49
KEGG	hsa00770	Pantothenate and CoA biosynthesis	6/1360	21/8135	0.1245	0.6441	0.5864	ALDH2/BCAT2/PPCS/DPYS/ALDH1B1/PPCDC	6
KEGG	hsa03013	Nucleocytoplasmic transport	23/1360	108/8135	0.1257	0.6441	0.5864	AAAS/NXT1/KPNA2/ALYREF/UBE2I/NUP93/RNPS1/NUP62/RAE1/DDX19B/NUP85/TNPO2/SEC13/SUMO4/RAN/SRRM1/MAGOH/KPNA6/SUMO3/NMD3/EEF1A1/PNN/RANGAP1	23
KEGG	hsa04260	Cardiac muscle contraction	19/1360	87/8135	0.128	0.646	0.5881	COX5A/CYC1/UQCRC1/COX4I1/CACNB1/UQCRFS1/UQCRQ/CACNA2D4/UQCR10/COX8A/COX6C/COX5B/CACNA2D3/ATP1A4/COX6B1/ASPH/UQCRH/COX7C/ATP1A3	19
KEGG	hsa04144	Endocytosis	49/1360	251/8135	0.1314	0.6528	0.5943	FOLR2/SH3GL1/AP2S1/ARPC5L/PLD2/SH3GLB2/CLTA/VPS37D/ARF5/AGAP3/IQSEC2/CYTH2/PSD3/ACAP3/CYTH3/VPS4A/MVB12B/CLTB/RAB4A/ARFGAP2/MVB12A/AMPH/ARF6/ARPC1A/RAB11B/ARRB1/CHMP4C/HRAS/SNF8/CHMP6/SNX4/VPS28/ARF1/AP2A1/PIP5K1C/HGS/HLA-F/PARD3/AP2M1/VPS37C/VPS25/SNX5/VPS45/AP2A2/GRK4/GIT1/EHD4/VPS26B/DNM3	49
KEGG	hsa00410	beta-Alanine metabolism	8/1360	31/8135	0.1333	0.6528	0.5943	ECHS1/ALDH2/HADHA/ACOX3/DPYS/ALDH1B1/CNDP2/CARNS1	8
KEGG	hsa04919	Thyroid hormone signaling pathway	25/1360	121/8135	0.1475	0.7119	0.6481	KAT2A/MED27/PLCB1/MED24/ITGB3/ACTG1/PLCB3/HDAC3/PFKFB2/PLCD1/HRAS/ATP1A4/NOTCH4/CCND1/PRKCG/PRKACA/MED30/PFKL/TSC2/BMP4/THRA/RXRB/ATP1A3/AKT1/ACTB	25
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	9/1360	37/8135	0.153	0.7279	0.6627	GOT2/GFPT2/ADSL/NAT8L/NIT2/ASL/GOT1/GLS2/IL4I1	9
KEGG	hsa04623	Cytosolic DNA-sensing pathway	14/1360	63/8135	0.1568	0.7344	0.6686	POLR2F/POLR2E/POLR1D/POLR3E/POLR1C/POLR3F/POLR2L/POLR3B/POLR3K/TREX1/IL18/AIM2/RELA/NFKBIB	14
KEGG	hsa03018	RNA degradation	17/1360	79/8135	0.1588	0.7344	0.6686	LSM4/EXOSC5/BTG3/EXOSC6/DCPS/EXOSC7/EDC3/EXOSC9/LSM7/WDR61/HSPA9/ENO3/EXOSC1/LSM2/PFKL/SKIV2L/EXOSC8	17
KEGG	hsa00511	Other glycan degradation	5/1360	18/8135	0.1696	0.7622	0.6939	MAN2C1/ENGASE/HEXA/MAN2B1/FUCA2	5
KEGG	hsa05330	Allograft rejection	9/1360	38/8135	0.1726	0.7622	0.6939	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/IL12A/CD40LG/HLA-F/HLA-DRA	9
KEGG	hsa05340	Primary immunodeficiency	9/1360	38/8135	0.1726	0.7622	0.6939	ADA/AICDA/CD8B/RFXANK/CD8A/CD4/CD3E/CD40LG/ZAP70	9
KEGG	hsa03060	Protein export	6/1360	23/8135	0.174	0.7622	0.6939	IMMP1L/SEC61B/SRP68/SEC61A1/SPCS1/SEC11C	6
KEGG	hsa01230	Biosynthesis of amino acids	16/1360	75/8135	0.177	0.7653	0.6967	IDH3G/IDH3A/IDH3B/BCAT2/IDH2/SDSL/GOT2/ARG1/SHMT2/PC/ENO3/ASL/PKM/PFKL/GOT1/RPIA	16
KEGG	hsa05130	Pathogenic Escherichia coli infection	38/1360	197/8135	0.1874	0.8002	0.7285	ARHGEF1/BAIAP2/ARPC5L/TUBB4A/TLR5/TNF/CYTH2/TRAF2/ABCF2/CYTH3/TAB1/TUBB2B/TLR4/ACTG1/ARF6/ARPC1A/TUBB/MYO1G/EZR/ARF1/RPS3/MYO1B/MYO10/FYN/BAX/IL18/TUBB2A/SLC9A3R1/SEC24C/NAIP/BRK1/RELA/IRAK1/NFKBIB/ACTB/NCL/CLDN15/ARHGEF12	38
KEGG	hsa00531	Glycosaminoglycan degradation	5/1360	19/8135	0.2005	0.845	0.7693	HEXA/NAGLU/GUSB/HGSNAT/SGSH	5
KEGG	hsa00100	Steroid biosynthesis	5/1360	20/8135	0.233	0.9639	0.8776	EBP/NSDHL/DHCR7/CYP24A1/LSS	5
KEGG	hsa01212	Fatty acid metabolism	12/1360	57/8135	0.2352	0.9639	0.8776	ECHS1/ACADVL/TECR/HSD17B8/ACAA2/HADHA/OXSM/ACOX3/ACADSB/ACSF3/MECR/ACSL1	12
KEGG	hsa05219	Bladder cancer	9/1360	41/8135	0.2374	0.9639	0.8776	THBS1/UPK3A/EGF/HRAS/CDK4/CCND1/E2F1/ARAF/MMP1	9
KEGG	hsa04922	Glucagon signaling pathway	21/1360	107/8135	0.2431	0.9755	0.888	G6PC3/CREB3/PHKG2/PLCB1/PRMT1/PLCB3/PDHA1/GYS1/SIK1/PCK2/CRTC2/PKM/FBP1/PRKACA/PFKL/PPP4C/GCK/PRKAG3/PYGB/CALML6/AKT1	21
KEGG	hsa00052	Galactose metabolism	7/1360	31/8135	0.2524	0.9888	0.9002	G6PC3/AKR1B1/MGAM/GALE/PFKL/GCK/GALT	7
KEGG	hsa05310	Asthma	7/1360	31/8135	0.2524	0.9888	0.9002	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/CD40LG/HLA-DRA	7
KEGG	hsa04152	AMPK signaling pathway	23/1360	120/8135	0.2683	1	0.9104	EIF4EBP1/CCNA1/G6PC3/CREB3/RPS6KB2/AKT1S1/GYS1/PFKFB2/RAB11B/PCK2/PPP2R1A/ELAVL1/CRTC2/IRS1/PPP2R5D/CCND1/FBP1/PFKL/TSC2/PRKAG3/PPP2R2D/AKT1/ADIPOR2	23
KEGG	hsa05164	Influenza A	32/1360	171/8135	0.2686	1	0.9104	NXT1/KPNA2/PABPN1/CPSF4/HLA-DMA/HLA-DPB1/RAE1/TNF/SLC25A5/HLA-DMB/SLC25A6/HLA-DPA1/IL12A/TLR4/RSAD2/ACTG1/RAB11B/CDK4/FDPS/KPNA6/HLA-DRA/MX2/TRIM25/BAX/IL18/EIF2AK2/VDAC1/RELA/NFKBIB/AKT1/ACTB/MX1	32
KEGG	hsa05222	Small cell lung cancer	18/1360	92/8135	0.2693	1	0.9104	TRAF4/ITGA2/TRAF2/CDKN1B/CDK4/CDKN2B/CCND1/BAX/LAMC1/E2F1/CKS1B/DDB2/PTEN/SKP2/RELA/RXRB/AKT1/BCL2	18
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1360	11/8135	0.2748	1	0.9104	HPD/VKORC1/COQ5	3
KEGG	hsa04142	Lysosome	25/1360	132/8135	0.278	1	0.9104	GGA1/CLTA/GNPTG/NAGPA/HEXA/CLTB/NAGLU/AP4B1/CTSW/AP1S1/PSAP/GM2A/GUSB/CTSH/AP1G2/AP4M1/HGSNAT/MAN2B1/FUCA2/AP1M1/CLN3/SMPD1/LAMP3/SGSH/NAGA	25
KEGG	hsa04940	Type I diabetes mellitus	9/1360	43/8135	0.2847	1	0.9104	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/IL12A/HLA-F/HLA-DRA/CPE	9
KEGG	hsa00062	Fatty acid elongation	6/1360	27/8135	0.2907	1	0.9104	ECHS1/TECR/ACAA2/HADHA/ACOT2/MECR	6
KEGG	hsa05416	Viral myocarditis	12/1360	60/8135	0.2953	1	0.9104	HLA-DMA/HLA-DPB1/HLA-DMB/CXADR/HLA-DPA1/ACTG1/CD40LG/CCND1/HLA-F/HLA-DRA/FYN/ACTB	12
KEGG	hsa04672	Intestinal immune network for IgA production	10/1360	49/8135	0.2969	1	0.9104	HLA-DMA/HLA-DPB1/HLA-DMB/AICDA/HLA-DPA1/TGFB1/MADCAM1/CD40LG/HLA-DRA/MAP3K14	10
KEGG	hsa00220	Arginine biosynthesis	5/1360	22/8135	0.3019	1	0.9104	GOT2/ARG1/ASL/GOT1/GLS2	5
KEGG	hsa00340	Histidine metabolism	5/1360	22/8135	0.3019	1	0.9104	ALDH2/MAOA/ALDH1B1/CNDP2/CARNS1	5
KEGG	hsa04137	Mitophagy - animal	14/1360	72/8135	0.3117	1	0.9104	PGAM5/CSNK2B/UBA52/FIS1/RRAS/HRAS/SQSTM1/TBC1D17/BCL2L13/E2F1/USP30/TOMM7/CITED2/RELA	14
KEGG	hsa05218	Melanoma	14/1360	72/8135	0.3117	1	0.9104	FGF18/EGF/HRAS/CDK4/PDGFB/CCND1/PDGFC/BAX/E2F1/DDB2/ARAF/PTEN/AKT1/HGF	14
KEGG	hsa04145	Phagosome	28/1360	152/8135	0.3168	1	0.9104	THBS1/SCARB1/HLA-DMA/ITGA2/HLA-DPB1/TUBB4A/CALR/HLA-DMB/ATP6V1F/HLA-DPA1/SEC61B/TUBB2B/TLR4/ITGB3/ACTG1/TUBB/CD209/STX18/TLR2/SEC61A1/FCGR1A/HGS/HLA-F/HLA-DRA/TUBB2A/DYNC1LI1/ACTB/CANX	28
KEGG	hsa05145	Toxoplasmosis	21/1360	112/8135	0.3176	1	0.9104	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/TGFB1/TAB1/IL12A/TLR4/SOCS1/IL10RA/TLR2/CD40LG/HLA-DRA/LAMC1/RELA/GNAI2/IRAK1/NFKBIB/AKT1/BCL2	21
KEGG	hsa04612	Antigen processing and presentation	15/1360	78/8135	0.3186	1	0.9104	CD74/HLA-DMA/HLA-DPB1/CALR/TNF/HLA-DMB/HSP90AB1/CD8B/RFXANK/HLA-DPA1/CD8A/CD4/HLA-F/HLA-DRA/CANX	15
KEGG	hsa00513	Various types of N-glycan biosynthesis	8/1360	39/8135	0.3227	1	0.9104	ALG2/B4GALT3/MAN1B1/ALG3/HEXA/ALG1/RPN2/ALG12	8
KEGG	hsa00515	Mannose type O-glycan biosynthesis	5/1360	23/8135	0.3374	1	0.9104	POMT1/B4GALT3/POMGNT1/POMT2/CHST10	5
KEGG	hsa03430	Mismatch repair	5/1360	23/8135	0.3374	1	0.9104	POLD2/LIG1/POLD4/RFC4/RPA1	5
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1360	79/8135	0.3375	1	0.9104	EIF4EBP1/RPS6KB2/EGF/EIF4E2/HRAS/PDGFB/PRKCG/PDGFC/BAX/ARAF/PTEN/AXL/AKT1/BCL2/HGF	15
KEGG	hsa00270	Cysteine and methionine metabolism	10/1360	51/8135	0.3439	1	0.9104	MDH2/BCAT2/SRM/SDSL/AHCY/GSS/GOT2/DNMT1/GOT1/IL4I1	10
KEGG	hsa00260	Glycine, serine and threonine metabolism	8/1360	40/8135	0.3497	1	0.9104	SDSL/GATM/GLYCTK/SHMT2/AMT/SRR/GRHPR/MAOA	8
KEGG	hsa03015	mRNA surveillance pathway	18/1360	97/8135	0.353	1	0.9104	NXT1/ALYREF/PABPN1/CPSF4/RNPS1/GSPT2/SSU72/PPP1CA/DAZAP1/DDX19B/CPSF1/SRRM1/PPP2R1A/MAGOH/PPP2R5D/CPSF6/PPP2R2D/PNN	18
KEGG	hsa04110	Cell cycle	23/1360	126/8135	0.3564	1	0.9104	MAD2L2/CCNA1/ANAPC11/CDKN1C/MCM5/CHEK2/MCM7/ANAPC2/TGFB1/CDKN1B/MAD1L1/BUB3/CDC25B/CDK4/CDKN2B/DBF4/CCND1/ANAPC15/FZR1/E2F1/CDC7/SKP2/CUL1	23
KEGG	hsa00983	Drug metabolism - other enzymes	15/1360	80/8135	0.3566	1	0.9104	GSTP1/ITPA/UPP1/UCKL1/GMPS/NME3/CYP2E1/TPMT/UCK1/GUSB/UCK2/MGST2/DPYS/NME1/UPP2	15
KEGG	hsa04920	Adipocytokine signaling pathway	13/1360	69/8135	0.3653	1	0.9104	G6PC3/TNF/TRAF2/NFKBIE/PCK2/IRS1/PRKAG3/RELA/RXRB/NFKBIB/AKT1/ADIPOR2/ACSL1	13
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1360	24/8135	0.3732	1	0.9104	EXTL2/B4GALT7/B3GAT3/XYLT2/B3GALT6	5
KEGG	hsa03450	Non-homologous end-joining	3/1360	13/8135	0.3739	1	0.9104	FEN1/XRCC6/POLL	3
KEGG	hsa04216	Ferroptosis	8/1360	41/8135	0.377	1	0.9104	SAT2/GPX4/HMOX1/GSS/SLC3A2/SLC7A11/VDAC2/ACSL1	8
KEGG	hsa00030	Pentose phosphate pathway	6/1360	30/8135	0.3865	1	0.9104	GPI/PGLS/GLYCTK/FBP1/PFKL/RPIA	6
KEGG	hsa00230	Purine metabolism	23/1360	128/8135	0.3872	1	0.9104	ITPA/NUDT2/ADA/AMPD2/DGUOK/ENTPD6/APRT/NT5C/GUK1/PFAS/ADSL/PDE6B/PDE6D/GMPS/NPR2/NME3/AK2/PDE3A/HDDC3/PDE1A/PDE5A/NME1/ENTPD1	23
KEGG	hsa04350	TGF-beta signaling pathway	17/1360	94/8135	0.4025	1	0.9104	ID3/THBS1/TGIF1/SMAD7/TNF/RPS6KB2/TGFB1/ID2/PPP2R1A/GREM2/CDKN2B/FBN1/LTBP1/BMP4/ID1/INHBB/CUL1	17
KEGG	hsa04211	Longevity regulating pathway	16/1360	89/8135	0.4179	1	0.9104	EIF4EBP1/EHMT2/CREB3/RPS6KB2/AKT1S1/EIF4E2/EHMT1/HRAS/IRS1/PRKACA/BAX/TSC2/PRKAG3/RELA/AKT1/ADIPOR2	16
KEGG	hsa05143	African trypanosomiasis	7/1360	37/8135	0.4259	1	0.9104	TNF/THOP1/PLCB1/IL12A/PLCB3/PRKCG/IL18	7
KEGG	hsa04071	Sphingolipid signaling pathway	21/1360	119/8135	0.4302	1	0.9104	ADORA1/PLD2/TNF/S1PR5/TRAF2/PLCB1/PLCB3/PPP2R1A/HRAS/PPP2R5D/CERS3/PRKCG/FYN/BAX/PTEN/SMPD1/PPP2R2D/RELA/GNAI2/AKT1/BCL2	21
KEGG	hsa04721	Synaptic vesicle cycle	14/1360	78/8135	0.4314	1	0.9104	AP2S1/VAMP2/CLTA/SLC18A2/ATP6V1F/RAB3A/CLTB/SLC18A1/AP2A1/SLC6A9/AP2M1/AP2A2/SLC1A3/DNM3	14
KEGG	hsa00565	Ether lipid metabolism	9/1360	49/8135	0.4364	1	0.9104	PLD4/TMEM189/PLD2/LPCAT4/JMJD7-PLA2G4B/PLA2G7/PAFAH1B3/PLD3/PLA2G5	9
KEGG	hsa05146	Amoebiasis	18/1360	102/8135	0.4411	1	0.9104	CD1D/SERPINB6/TNF/CD1C/PLCB1/TGFB1/IL12A/TLR4/PLCB3/ARG1/TLR2/IL1R2/HSPB1/PRKCG/PRKACA/LAMC1/GNAL/RELA	18
KEGG	hsa04659	Th17 cell differentiation	19/1360	108/8135	0.4431	1	0.9104	GATA3/HLA-DMA/IL4R/HLA-DPB1/HLA-DMB/HSP90AB1/HLA-DPA1/IL27RA/TGFB1/TBX21/NFKBIE/CD4/CD3E/ZAP70/HLA-DRA/IL21R/RELA/RXRB/NFKBIB	19
KEGG	hsa04931	Insulin resistance	19/1360	108/8135	0.4431	1	0.9104	G6PC3/CREB3/TNF/RPS6KB2/PPP1CA/SLC27A1/GYS1/NR1H3/GFPT2/PCK2/CRTC2/PPP1R3B/IRS1/SLC27A3/PTEN/PRKAG3/PYGB/RELA/AKT1	19
KEGG	hsa04115	p53 signaling pathway	13/1360	73/8135	0.4493	1	0.9104	SIVA1/THBS1/GORAB/CHEK2/BBC3/CDK4/CCND1/BAX/DDB2/TSC2/PTEN/BCL2/IGFBP3	13
KEGG	hsa00640	Propanoate metabolism	6/1360	32/8135	0.4506	1	0.9104	ECHS1/HADHA/BCKDHB/PCCB/ACOX3/ACSS1	6
KEGG	hsa05225	Hepatocellular carcinoma	29/1360	168/8135	0.4568	1	0.9104	GSTP1/SMARCB1/TXNRD2/HMOX1/SMARCA4/RPS6KB2/TGFB1/ACTG1/DVL2/HRAS/CDK4/TERT/WNT10B/CCND1/PRKCG/BAX/MGST2/E2F1/DDB2/DVL1/ARAF/SMARCD2/SMARCE1/PTEN/FZD8/SMARCD1/AKT1/ACTB/HGF	29
KEGG	hsa05215	Prostate cancer	17/1360	97/8135	0.4573	1	0.9104	GSTP1/CREB3/HSP90AB1/SPINT1/CDKN1B/EGF/HRAS/PDGFB/IL1R2/CCND1/PDGFC/E2F1/ARAF/PTEN/RELA/AKT1/BCL2	17
KEGG	hsa05110	Vibrio cholerae infection	9/1360	50/8135	0.4619	1	0.9104	KDELR1/ATP6V1F/SEC61B/ACTG1/PDIA4/ARF1/SEC61A1/PRKACA/ACTB	9
KEGG	hsa05418	Fluid shear stress and atherosclerosis	24/1360	139/8135	0.4663	1	0.9104	GSTP1/TXN2/EDN1/PIAS4/HMOX1/MAP2K7/TNF/HSP90AB1/MAP2K5/ITGB3/ACTG1/SUMO4/SDC1/PDGFB/IL1R2/SQSTM1/SUMO3/MGST2/BMP4/RELA/CALML6/AKT1/BCL2/ACTB	24
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1360	15/8135	0.47	1	0.9104	ST6GALNAC6/HEXA/ST6GALNAC4	3
KEGG	hsa04658	Th1 and Th2 cell differentiation	16/1360	92/8135	0.4744	1	0.9104	GATA3/HLA-DMA/IL4R/HLA-DPB1/HLA-DMB/HLA-DPA1/TBX21/NFKBIE/IL12A/CD4/CD3E/ZAP70/RUNX3/HLA-DRA/RELA/NFKBIB	16
KEGG	hsa03022	Basal transcription factors	8/1360	45/8135	0.4858	1	0.9104	TAF6L/ERCC2/TAF6/GTF2F1/ERCC3/MNAT1/TBP/TBPL1	8
KEGG	hsa04918	Thyroid hormone synthesis	13/1360	75/8135	0.4911	1	0.9104	CREB3/ASGR1/TG/PLCB1/PLCB3/PDIA4/ATP1A4/PRKCG/PRKACA/GPX3/TTF1/ATP1A3/CANX	13
KEGG	hsa05214	Glioma	13/1360	75/8135	0.4911	1	0.9104	EGF/HRAS/CDK4/PDGFB/CCND1/PRKCG/BAX/E2F1/DDB2/ARAF/PTEN/CALML6/AKT1	13
KEGG	hsa04971	Gastric acid secretion	13/1360	76/8135	0.5118	1	0.9104	PLCB1/ACTG1/PLCB3/ATP1A4/EZR/KCNJ2/PRKCG/PRKACA/SSTR2/GNAI2/ATP1A3/CALML6/ACTB	13
KEGG	hsa05230	Central carbon metabolism in cancer	12/1360	70/8135	0.5118	1	0.9104	IDH2/SIRT6/PDHA1/HRAS/SLC1A5/PKM/PFKL/GCK/SIRT3/PTEN/GLS2/AKT1	12
KEGG	hsa04910	Insulin signaling pathway	23/1360	137/8135	0.5273	1	0.9104	EIF4EBP1/TRIP10/G6PC3/PHKG2/RPS6KB2/PPP1CA/SOCS1/EIF4E2/GYS1/PCK2/SOCS2/HRAS/PPP1R3B/IRS1/FBP1/PRKACA/TSC2/ARAF/GCK/PRKAG3/PYGB/CALML6/AKT1	23
KEGG	hsa05135	Yersinia infection	23/1360	137/8135	0.5273	1	0.9104	ARHGEF1/BAIAP2/ARPC5L/MAP2K7/TNF/CD8B/TRAF2/CD8A/TAB1/TLR4/PKN1/ACTG1/CD4/ARF6/ARPC1A/PIP5K1C/ZAP70/IL18/RELA/IRAK1/AKT1/ACTB/ARHGEF12	23
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1360	89/8135	0.5307	1	0.9104	BATF3/CSNK2B/RPS6KB2/NFKBIE/TLR4/EGF/CD4/CD3E/HRAS/TLR2/ZAP70/PTEN/RELA/NFKBIB/AKT1	15
KEGG	hsa00514	Other types of O-glycan biosynthesis	8/1360	47/8135	0.5385	1	0.9104	GALNT14/POMT1/B4GALT3/XXYLT1/GALNT11/PLOD3/POMT2/POFUT1	8
KEGG	hsa04973	Carbohydrate digestion and absorption	8/1360	47/8135	0.5385	1	0.9104	G6PC3/PLCB1/PLCB3/MGAM/ATP1A4/SLC37A4/ATP1A3/AKT1	8
KEGG	hsa05152	Tuberculosis	30/1360	180/8135	0.5392	1	0.9104	CD74/CR1/HLA-DMA/HLA-DPB1/TNF/HLA-DMB/CEBPG/RFXANK/HLA-DPA1/TGFB1/IL12A/TLR4/IL10RA/CR1L/CD209/TLR2/HSPA9/FCGR1A/HLA-DRA/BAX/IL18/CARD9/CLEC4E/RELA/IRAK1/LSP1/CALML6/AKT1/BCL2/ARHGEF12	30
KEGG	hsa04218	Cellular senescence	26/1360	156/8135	0.5409	1	0.9104	EIF4EBP1/RAD9A/CCNA1/CHEK2/SLC25A5/SLC25A6/TGFB1/PPP1CA/RRAS/HRAS/HIPK2/CDK4/CDKN2B/RAD1/CCND1/SQSTM1/HLA-F/E2F1/TSC2/PTEN/VDAC2/VDAC1/RELA/CALML6/AKT1/IGFBP3	26
KEGG	hsa04392	Hippo signaling pathway - multiple species	5/1360	29/8135	0.5468	1	0.9104	TEAD2/CSNK1E/RASSF4/TEAD3/NF2	5
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	4/1360	23/8135	0.5517	1	0.9104	PCK2/ATP1A4/GLS2/ATP1A3	4
KEGG	hsa05223	Non-small cell lung cancer	12/1360	72/8135	0.5541	1	0.9104	EGF/HRAS/CDK4/CCND1/PRKCG/BAX/E2F1/DDB2/ARAF/RXRB/AKT1/HGF	12
KEGG	hsa04390	Hippo signaling pathway	26/1360	157/8135	0.5551	1	0.9104	TEAD2/CSNK1E/SMAD7/TGFB1/SCRIB/PPP1CA/LLGL2/TEAD3/BBC3/DLG4/ID2/ACTG1/NF2/DVL2/LLGL1/PPP2R1A/WNT10B/CCND1/PARD3/DVL1/BMP4/DLG5/FZD8/PPP2R2D/ID1/ACTB	26
KEGG	hsa04978	Mineral absorption	10/1360	60/8135	0.5583	1	0.9104	MT1F/MT1E/MT1X/HMOX1/HMOX2/ATP1A4/SLC31A1/SLC30A1/ATP1A3/ATP7B	10
KEGG	hsa05332	Graft-versus-host disease	7/1360	42/8135	0.5679	1	0.9104	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/HLA-F/HLA-DRA	7
KEGG	hsa00500	Starch and sucrose metabolism	6/1360	36/8135	0.5727	1	0.9104	G6PC3/GPI/GYS1/MGAM/GCK/PYGB	6
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	6/1360	36/8135	0.5727	1	0.9104	SIRT7/NADSYN1/SIRT2/SIRT6/NT5C/SIRT3	6
KEGG	hsa05221	Acute myeloid leukemia	11/1360	67/8135	0.5775	1	0.9104	EIF4EBP1/CCNA1/RPS6KB2/HRAS/PPARD/CCND1/FCGR1A/ARAF/CSF1R/RELA/AKT1	11
KEGG	hsa01523	Antifolate resistance	5/1360	30/8135	0.5789	1	0.9104	FOLR2/TNF/FPGS/SHMT2/RELA	5
KEGG	hsa00590	Arachidonic acid metabolism	10/1360	61/8135	0.5807	1	0.9104	CBR1/PTGES2/PTGES3/JMJD7-PLA2G4B/PTGDS/CYP2E1/GPX3/PLA2G5/CYP2C8/AKR1C3	10
KEGG	hsa04660	T cell receptor signaling pathway	17/1360	104/8135	0.5819	1	0.9104	MAP2K7/TNF/CD8B/CD8A/NFKBIE/CD4/CD3E/HRAS/CDK4/CD40LG/ZAP70/FYN/PAK4/RELA/MAP3K14/NFKBIB/AKT1	17
KEGG	hsa00564	Glycerophospholipid metabolism	16/1360	98/8135	0.584	1	0.9104	DGKH/PLD4/PLD2/LPCAT4/DGKZ/GPAT2/JMJD7-PLA2G4B/PEMT/ETNK2/LYPLA2/PTDSS2/PLD3/AGPAT3/PLA2G5/TAZ/PCYT2	16
KEGG	hsa04072	Phospholipase D signaling pathway	24/1360	148/8135	0.6002	1	0.9104	DGKH/PLD2/CYTH2/DGKZ/PLCB1/CYTH3/EGF/RRAS/PLCB3/ARF6/JMJD7-PLA2G4B/HRAS/ARF1/PDGFB/PIP5K1C/FYN/PDGFC/TSC2/AGPAT3/AVPR2/GRM2/AKT1/AVP/DNM3	24
KEGG	hsa04611	Platelet activation	20/1360	124/8135	0.608	1	0.9104	ARHGEF1/PTGIR/VAMP8/ITGA2/GP5/PLCB1/PPP1CA/P2RY1/ITGB3/ACTG1/PLCB3/JMJD7-PLA2G4B/RASGRP2/VWF/FYN/PRKACA/GNAI2/AKT1/ACTB/ARHGEF12	20
KEGG	hsa04710	Circadian rhythm	5/1360	31/8135	0.6097	1	0.9104	CSNK1E/CRY1/BHLHE40/PRKAG3/CUL1	5
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/1360	100/8135	0.6185	1	0.9104	EDN1/TNF/PLCB1/TGFB1/CDKN1B/VEGFB/PLCB3/PLCD1/HRAS/CDK4/CCND1/BAX/RELA/AKT1/BCL2/AGER	16
KEGG	hsa04924	Renin secretion	11/1360	69/8135	0.619	1	0.9104	ADORA1/EDN1/PLCB1/KCNMA1/PLCB3/KCNJ2/PDE3A/PRKACA/PDE1A/GNAI2/CALML6	11
KEGG	hsa04540	Gap junction	14/1360	88/8135	0.6254	1	0.9104	TUBB4A/MAP2K5/PLCB1/TUBB2B/EGF/PLCB3/TUBB/HRAS/PDGFB/PRKCG/PRKACA/PDGFC/TUBB2A/GNAI2	14
KEGG	hsa04150	mTOR signaling pathway	25/1360	156/8135	0.6261	1	0.9104	EIF4EBP1/GRB10/TELO2/LAMTOR2/TNF/WDR59/ATP6V1F/RPS6KB2/MLST8/AKT1S1/SLC3A2/SEC13/EIF4E2/DVL2/HRAS/NPRL3/WNT10B/IRS1/PRKCG/DVL1/TSC2/PTEN/FZD8/SKP2/AKT1	25
KEGG	hsa05212	Pancreatic cancer	12/1360	76/8135	0.6339	1	0.9104	PLD2/RPS6KB2/TGFB1/EGF/CDK4/CCND1/BAX/E2F1/DDB2/ARAF/RELA/AKT1	12
KEGG	hsa05220	Chronic myeloid leukemia	12/1360	76/8135	0.6339	1	0.9104	CTBP1/TGFB1/CDKN1B/HRAS/CDK4/CCND1/BAX/E2F1/DDB2/ARAF/RELA/AKT1	12
KEGG	hsa04728	Dopaminergic synapse	21/1360	132/8135	0.6354	1	0.9104	CREB3/SLC18A2/PLCB1/PPP1CA/LRTOMT/COMT/GNGT2/SLC18A1/PLCB3/ARRB1/PPP2R1A/PPP2R5D/PRKCG/PRKACA/GNAL/MAOA/PPP2R2D/GNAI2/CALML6/AKT1/GSK3A	21
KEGG	hsa00480	Glutathione metabolism	9/1360	58/8135	0.6515	1	0.9104	GSTP1/GPX4/IDH2/SRM/GSS/GGCT/GGT7/MGST2/GPX3	9
KEGG	hsa05142	Chagas disease	16/1360	102/8135	0.6517	1	0.9104	CALR/TNF/PLCB1/TGFB1/IL12A/TLR4/CD3E/PLCB3/PPP2R1A/TLR2/GNAL/PPP2R2D/RELA/GNAI2/IRAK1/AKT1	16
KEGG	hsa05410	Hypertrophic cardiomyopathy	14/1360	90/8135	0.6604	1	0.9104	EDN1/EMD/ITGA2/CACNB1/CACNA2D4/TNF/TGFB1/ITGA1/ITGA7/ITGB3/ACTG1/CACNA2D3/PRKAG3/ACTB	14
KEGG	hsa04930	Type II diabetes mellitus	7/1360	46/8135	0.6685	1	0.9104	CACNA1E/TNF/SOCS1/SOCS2/IRS1/PKM/GCK	7
KEGG	hsa00670	One carbon pool by folate	3/1360	20/8135	0.6738	1	0.9104	SHMT2/AMT/MTHFD1	3
KEGG	hsa05320	Autoimmune thyroid disease	8/1360	53/8135	0.681	1	0.9104	HLA-DMA/HLA-DPB1/HLA-DMB/TG/HLA-DPA1/CD40LG/HLA-F/HLA-DRA	8
KEGG	hsa04064	NF-kappa B signaling pathway	16/1360	104/8135	0.6832	1	0.9104	UBE2I/CSNK2B/PIAS4/TNF/EDA/TRAF2/TAB1/TLR4/CD40LG/ZAP70/TRIM25/RELA/MAP3K14/IRAK1/EDARADD/BCL2	16
KEGG	hsa05203	Viral carcinogenesis	32/1360	204/8135	0.6842	1	0.9104	KAT2A/CCNA1/SND1/CREB3/RANBP1/TRAF2/HDAC8/SCRIB/CDKN1B/HDAC4/DNAJA3/HDAC3/MAD1L1/HRAS/TBP/HDAC10/EGR2/CDK4/HDAC6/CDKN2B/UBR4/PKM/CCND1/HLA-F/PRKACA/BAX/DDB1/MRPS18B/EIF2AK2/SKP2/RELA/TBPL1	32
KEGG	hsa01522	Endocrine resistance	15/1360	98/8135	0.6881	1	0.9104	RPS6KB2/CDKN1B/CYP2D6/CARM1/HRAS/CDK4/NOTCH4/CCND1/PRKACA/BAX/E2F1/ARAF/AKT1/BCL2/GPER1	15
KEGG	hsa00040	Pentose and glucuronate interconversions	5/1360	34/8135	0.6938	1	0.9104	CRYL1/AKR1B1/DCXR/AKR1A1/GUSB	5
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1360	14/8135	0.706	1	0.9104	B4GALT3/B3GNT7	2
KEGG	hsa00140	Steroid hormone biosynthesis	9/1360	61/8135	0.7118	1	0.9104	HSD17B8/SRD5A3/LRTOMT/COMT/CYP2E1/HSD17B6/CYP1B1/AKR1C1/AKR1C3	9
KEGG	hsa00561	Glycerolipid metabolism	9/1360	61/8135	0.7118	1	0.9104	DGKH/ALDH2/DGKZ/GPAT2/AKR1B1/GLYCTK/AKR1A1/AGPAT3/ALDH1B1	9
KEGG	hsa00650	Butanoate metabolism	4/1360	28/8135	0.7121	1	0.9104	ECHS1/HMGCL/HADHA/ACSM5	4
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1360	106/8135	0.7131	1	0.9104	ARHGEF1/PLD2/GATA3/CREB3/PLCB1/PLCB3/ARRB1/CYP24A1/PRKCG/PRKACA/MEF2D/SLC9A3R1/ARAF/GNAI2/RXRB/BCL2	16
KEGG	hsa05162	Measles	21/1360	139/8135	0.7299	1	0.9104	CSNK2B/CDKN1B/BBC3/IL12A/TLR4/CD3E/CD209/TLR2/CDK4/CCND1/MX2/BAX/EIF3H/RAB9A/EIF2AK2/RELA/IRAK1/NFKBIB/AKT1/BCL2/MX1	21
KEGG	hsa03320	PPAR signaling pathway	11/1360	75/8135	0.7299	1	0.9104	SLC27A1/ME1/NR1H3/FABP5/PCK2/ME3/PPARD/ACOX3/MMP1/RXRB/ACSL1	11
KEGG	hsa04213	Longevity regulating pathway - multiple species	9/1360	62/8135	0.7304	1	0.9104	RPS6KB2/AKT1S1/HRAS/IRS1/CLPB/PRKACA/SOD1/PRKAG3/AKT1	9
KEGG	hsa00591	Linoleic acid metabolism	4/1360	29/8135	0.7386	1	0.9104	JMJD7-PLA2G4B/CYP2E1/PLA2G5/CYP2C8	4
KEGG	hsa04744	Phototransduction	4/1360	29/8135	0.7386	1	0.9104	RGS9/PDE6B/GUCA1A/CALML6	4
KEGG	hsa04340	Hedgehog signaling pathway	8/1360	56/8135	0.7409	1	0.9104	CSNK1E/ARRB1/CSNK1G2/CCND1/PRKACA/HHAT/CUL1/BCL2	8
KEGG	hsa05131	Shigellosis	38/1360	247/8135	0.741	1	0.9104	CAPNS1/ARPC5L/ATG14/ATG16L1/TLR5/PFN1/TNF/UBA52/CYTH2/RPS6KB2/AKT1S1/TRAF2/PLCB1/CYTH3/TAB1/TLR4/ACTG1/PLCB3/ARF6/ARPC1A/SHARPIN/PLCD1/ARF1/SQSTM1/UBE2D4/BAX/IL18/FNBP1L/FOXO6/NAIP/VDAC1/RELA/NFKBIB/CUL1/AKT1/BCL2/ACTB/GSK3A	38
KEGG	hsa04217	Necroptosis	24/1360	159/8135	0.7416	1	0.9104	PGAM5/TNF/SLC25A5/HSP90AB1/SLC25A6/TRAF2/VPS4A/TLR4/JMJD7-PLA2G4B/FAF1/SHARPIN/CHMP4C/CHMP6/SPATA2/SQSTM1/BAX/AIFM1/USP21/EIF2AK2/SMPD1/PYGB/VDAC2/VDAC1/BCL2	24
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1360	15/8135	0.7423	1	0.9104	HEXA/NAGA	2
KEGG	hsa00730	Thiamine metabolism	2/1360	15/8135	0.7423	1	0.9104	ALPL/AK2	2
KEGG	hsa04270	Vascular smooth muscle contraction	20/1360	134/8135	0.7465	1	0.9104	ARHGEF1/EDN1/PTGIR/PPP1R12C/ADM2/PLCB1/PPP1CA/KCNMA1/PLCB3/JMJD7-PLA2G4B/NPR2/PRKCG/PRKACA/CALD1/ARAF/PLA2G5/CALML6/MYL6B/AVP/ARHGEF12	20
KEGG	hsa04914	Progesterone-mediated oocyte maturation	15/1360	102/8135	0.7472	1	0.9104	KIF22/MAD2L2/CCNA1/ANAPC11/HSP90AB1/ANAPC2/CPEB3/MAD1L1/CDC25B/ANAPC15/PRKACA/FZR1/ARAF/GNAI2/AKT1	15
KEGG	hsa04975	Fat digestion and absorption	6/1360	43/8135	0.7476	1	0.9104	SCARB1/ABCA1/GOT2/SLC27A1/PLA2G5/MTTP	6
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1360	77/8135	0.7617	1	0.9104	EMD/ITGA2/CACNB1/CACNA2D4/ITGA1/DSC2/ITGA7/ITGB3/ACTG1/CACNA2D3/ACTB	11
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/1360	30/8135	0.7631	1	0.9104	ALDH2/AKR1A1/GUSB/ALDH1B1	4
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	5/1360	37/8135	0.7646	1	0.9104	ATP1A4/IRS1/PRKCG/SLC9A3R2/ATP1A3	5
KEGG	hsa05216	Thyroid cancer	5/1360	37/8135	0.7646	1	0.9104	HRAS/CCND1/BAX/DDB2/RXRB	5
KEGG	hsa04614	Renin-angiotensin system	3/1360	23/8135	0.7651	1	0.9104	THOP1/PREP/NLN	3
KEGG	hsa05170	Human immunodeficiency virus 1 infection	32/1360	212/8135	0.7661	1	0.9104	RNF7/CALR/MAP2K7/TNF/RPS6KB2/TRAF2/TAB1/APOBEC3G/GNGT2/TLR4/CD4/CD3E/HRAS/AP1S1/TLR2/PRKCG/HLA-F/BAX/AP1G2/APOBEC3D/PAK4/DDB1/AP1M1/RELA/GNAI2/IRAK1/CUL4A/CUL1/CALML6/AKT1/BCL2/LIMK2	32
KEGG	hsa04625	C-type lectin receptor signaling pathway	15/1360	104/8135	0.7738	1	0.9104	TNF/IL12A/RRAS/CLEC4D/CD209/HRAS/EGR2/CARD9/CLEC4E/RELA/MAP3K14/LSP1/CALML6/AKT1/ARHGEF12	15
KEGG	hsa05213	Endometrial cancer	8/1360	58/8135	0.7763	1	0.9104	EGF/HRAS/CCND1/BAX/DDB2/ARAF/PTEN/AKT1	8
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1360	78/8135	0.7766	1	0.9104	GSTP1/EPHX1/CBR1/AKR7A2/CYP2S1/CYP2D6/CYP2E1/ADH5/MGST2/CYP1B1/AKR1C1	11
KEGG	hsa05231	Choline metabolism in cancer	14/1360	98/8135	0.7805	1	0.9104	EIF4EBP1/DGKH/PLD2/RPS6KB2/DGKZ/EGF/JMJD7-PLA2G4B/HRAS/PDGFB/PIP5K1C/PRKCG/PDGFC/TSC2/AKT1	14
KEGG	hsa04068	FoxO signaling pathway	19/1360	131/8135	0.7863	1	0.9104	G6PC3/CSNK1E/TGFB1/CDKN1B/PLK2/EGF/PRMT1/FBXO25/PCK2/HRAS/CDKN2B/IRS1/CCND1/FOXO6/ARAF/PTEN/PRKAG3/SKP2/AKT1	19
KEGG	hsa04330	Notch signaling pathway	8/1360	59/8135	0.7926	1	0.9104	KAT2A/DTX3/CTBP1/DVL2/NOTCH4/NUMBL/DVL1/PSENEN	8
KEGG	hsa04911	Insulin secretion	12/1360	86/8135	0.7958	1	0.9104	VAMP2/CREB3/PLCB1/RAB3A/KCNMA1/PLCB3/TRPM4/ATP1A4/PRKCG/PRKACA/GCK/ATP1A3	12
KEGG	hsa04722	Neurotrophin signaling pathway	17/1360	119/8135	0.7974	1	0.9104	ARHGDIA/MATK/MAP2K7/MAP2K5/SH2B1/NFKBIE/HRAS/SH2B3/IRS1/MAGED1/BAX/RELA/IRAK1/NFKBIB/CALML6/AKT1/BCL2	17
KEGG	hsa00562	Inositol phosphate metabolism	10/1360	73/8135	0.8003	1	0.9104	PLCB1/PI4K2A/PLCB3/PLCD1/INPP5K/PLCH2/PIP5K1C/ISYNA1/PTEN/PI4KB	10
KEGG	hsa01524	Platinum drug resistance	10/1360	73/8135	0.8003	1	0.9104	GSTP1/ERCC1/XPA/BBC3/BAX/MGST2/SLC31A1/ATP7B/AKT1/BCL2	10
KEGG	hsa00120	Primary bile acid biosynthesis	2/1360	17/8135	0.8035	1	0.9104	CH25H/CYP46A1	2
KEGG	hsa00450	Selenocompound metabolism	2/1360	17/8135	0.8035	1	0.9104	TXNRD2/PSTK	2
KEGG	hsa04136	Autophagy - other	4/1360	32/8135	0.8068	1	0.9104	ATG4B/ATG16L1/MLST8/ATG4D	4
KEGG	hsa04730	Long-term depression	8/1360	60/8135	0.808	1	0.9104	PLCB1/PLCB3/JMJD7-PLA2G4B/PPP2R1A/HRAS/PRKCG/ARAF/GNAI2	8
KEGG	hsa05165	Human papillomavirus infection	50/1360	331/8135	0.809	1	0.9104	EIF4EBP1/THBS1/CCNA1/ITGA2/CREB3/TNF/ATP6V1F/RPS6KB2/SCRIB/LLGL2/CDKN1B/ITGA1/ITGA7/ITGB3/EGF/DVL2/COL6A2/LLGL1/PPP2R1A/HRAS/TBP/CDK4/TERT/UBR4/NOTCH4/WNT10B/PPP2R5D/PKM/CCND1/VWF/HLA-F/PARD3/MX2/PRKACA/BAX/LAMC1/BCAP31/E2F1/DVL1/TSC2/SLC9A3R1/TUBG2/PTEN/FZD8/EIF2AK2/PPP2R2D/RELA/TBPL1/AKT1/MX1	50
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1360	25/8135	0.8135	1	0.9104	JMJD7-PLA2G4B/ACOX3/PLA2G5	3
KEGG	hsa00830	Retinol metabolism	9/1360	68/8135	0.8245	1	0.9104	DHRS3/DHRS4/ALDH1A2/DHRS4L2/CYP2S1/ADH5/HSD17B6/CYP2C8/RDH10	9
KEGG	hsa04934	Cushing syndrome	22/1360	155/8135	0.8309	1	0.9104	RASD1/MEN1/SCARB1/AIP/CREB3/WDR5/PLCB1/CDKN1B/PLCB3/DVL2/NR4A1/CDK4/CDKN2B/WNT10B/CCND1/PRKACA/KMT2D/E2F1/DVL1/FZD8/FH/GNAI2	22
KEGG	hsa04936	Alcoholic liver disease	20/1360	142/8135	0.8316	1	0.9104	C3AR1/ACADVL/ALDH2/MAP2K7/TNF/TAB1/IL12A/IL17RC/TLR4/CCND1/CYP2E1/ADH5/ACOX3/ALDH1B1/PRKAG3/RELA/MAP3K14/IRAK1/AKT1/ADIPOR2	20
KEGG	hsa04066	HIF-1 signaling pathway	15/1360	109/8135	0.8317	1	0.9104	EIF4EBP1/EDN1/HMOX1/RPS6KB2/CDKN1B/TLR4/EGF/PDHA1/EIF4E2/ENO3/PRKCG/PFKL/RELA/AKT1/BCL2	15
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1360	26/8135	0.8344	1	0.9104	GPAA1/DPM2/PGAP1	3
KEGG	hsa05414	Dilated cardiomyopathy	13/1360	96/8135	0.8355	1	0.9104	EMD/ITGA2/CACNB1/CACNA2D4/TNF/TGFB1/ITGA1/ITGA7/ITGB3/ACTG1/CACNA2D3/PRKACA/ACTB	13
KEGG	hsa05226	Gastric cancer	21/1360	149/8135	0.8357	1	0.9104	RPS6KB2/TGFB1/FGF18/CDKN1B/EGF/DVL2/HRAS/TERT/CDKN2B/WNT10B/CCND1/BAX/E2F1/DDB2/DVL1/ARAF/FZD8/RXRB/AKT1/BCL2/HGF	21
KEGG	hsa04210	Apoptosis	19/1360	136/8135	0.8369	1	0.9104	TNF/TRAF2/BBC3/LMNB2/ACTG1/ENDOG/CTSW/HRAS/DDIT3/SPTA1/CTSH/BAX/PARP3/AIFM1/RELA/MAP3K14/AKT1/BCL2/ACTB	19
KEGG	hsa05211	Renal cell carcinoma	9/1360	69/8135	0.8374	1	0.9104	TGFB1/HRAS/PRCC/PDGFB/PAK4/ARAF/FH/AKT1/HGF	9
KEGG	hsa04530	Tight junction	24/1360	169/8135	0.839	1	0.9104	ARPC5L/CD1D/TJAP1/MAP2K7/CD1C/SCRIB/LLGL2/ACTG1/NF2/ARPC1A/LLGL1/PPP2R1A/YBX3/CDK4/EZR/CCND1/PARD3/PRKACA/SLC9A3R1/PRKAG3/PPP2R2D/MYL6B/ACTB/CLDN15	24
KEGG	hsa00920	Sulfur metabolism	1/1360	10/8135	0.8397	1	0.9104	ETHE1	1
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	13/1360	97/8135	0.8461	1	0.9104	ARPC5L/PLD2/RPS6KB2/AMPH/ARF6/ARPC1A/JMJD7-PLA2G4B/PIP5K1C/FCGR1A/PRKCG/MYO10/AKT1/LIMK2	13
KEGG	hsa05160	Hepatitis C	22/1360	157/8135	0.8479	1	0.9104	SCARB1/CD81/TNF/TRAF2/RSAD2/EGF/NR1H3/PPP2R1A/HRAS/CDK4/CCND1/MX2/BAX/E2F1/ARAF/EIF2AK2/PPP2R2D/RELA/IFIT1/AKT1/MX1/CLDN15	22
KEGG	hsa04622	RIG-I-like receptor signaling pathway	9/1360	70/8135	0.8495	1	0.9104	PIN1/TNF/TRAF2/RNF125/IL12A/SIKE1/TRIM25/RELA/NFKBIB	9
KEGG	hsa04917	Prolactin signaling pathway	9/1360	70/8135	0.8495	1	0.9104	SOCS1/SOCS2/PRL/HRAS/CCND1/GCK/GALT/RELA/AKT1	9
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/1360	27/8135	0.8532	1	0.9104	TECR/ACOT2/ACOX3	3
KEGG	hsa04015	Rap1 signaling pathway	30/1360	210/8135	0.8539	1	0.9104	THBS1/PFN1/PLCB1/FGF18/P2RY1/VEGFB/ITGB3/ACTG1/EGF/RRAS/PLCB3/DOCK4/HRAS/CTNND1/PDGFB/RASGRP2/SKAP1/EVL/PRKCG/PARD3/PDGFC/CSF1R/GNAI2/ID1/CALML6/EPHA2/AKT1/ACTB/SIPA1L2/HGF	30
KEGG	hsa04010	MAPK signaling pathway	43/1360	294/8135	0.8557	1	0.9104	RPS6KA4/PPP5C/DUSP7/CACNA1E/CACNB1/CACNA2D4/MAP2K7/TNF/MAP2K5/MAP4K1/TRAF2/TGFB1/FGF18/TAB1/VEGFB/EGF/DUSP2/RRAS/JMJD7-PLA2G4B/ARRB1/HRAS/NR4A1/CDC25B/CACNA2D3/PDGFB/RASGRP2/HSPB1/DDIT3/PRKCG/PRKACA/PDGFC/ARAF/TAOK2/CSF1R/RELA/MAP3K14/IRAK1/DUSP10/DUSP8/EPHA2/AKT1/MAPKAPK3/HGF	43
KEGG	hsa04520	Adherens junction	9/1360	71/8135	0.861	1	0.9104	BAIAP2/CSNK2B/SNAI1/ACTG1/CTNND1/PTPRM/FYN/PARD3/ACTB	9
KEGG	hsa05205	Proteoglycans in cancer	29/1360	205/8135	0.8641	1	0.9104	ARHGEF1/THBS1/ITGA2/PPP1R12C/NUDT16L1/TNF/RPS6KB2/TGFB1/PPP1CA/TLR4/ITGB3/ACTG1/RRAS/SDC1/HRAS/TLR2/ANK1/EZR/WNT10B/CCND1/PRKCG/PRKACA/ARAF/FZD8/TWIST1/AKT1/ACTB/HGF/ARHGEF12	29
KEGG	hsa05210	Colorectal cancer	11/1360	86/8135	0.8724	1	0.9104	RPS6KB2/TGFB1/BBC3/EGF/HRAS/CCND1/BAX/DDB2/ARAF/AKT1/BCL2	11
KEGG	hsa05323	Rheumatoid arthritis	12/1360	93/8135	0.8734	1	0.9104	HLA-DMA/HLA-DPB1/TNF/HLA-DMB/ATP6V1F/HLA-DPA1/TGFB1/TLR4/TLR2/HLA-DRA/IL18/MMP1	12
KEGG	hsa04921	Oxytocin signaling pathway	21/1360	154/8135	0.8755	1	0.9104	PPP1R12C/CACNB1/CACNA2D4/MAP2K5/PLCB1/PPP1CA/ACTG1/PLCB3/JMJD7-PLA2G4B/HRAS/CACNA2D3/KCNJ2/NPR2/CCND1/PRKCG/PRKACA/PRKAG3/GNAI2/CALML6/MYL6B/ACTB	21
KEGG	hsa04913	Ovarian steroidogenesis	6/1360	51/8135	0.8763	1	0.9104	SCARB1/JMJD7-PLA2G4B/ACOT2/PRKACA/CYP1B1/AKR1C3	6
KEGG	hsa04916	Melanogenesis	13/1360	101/8135	0.8832	1	0.9104	EDN1/CREB3/PLCB1/PLCB3/DVL2/HRAS/WNT10B/PRKCG/PRKACA/DVL1/FZD8/GNAI2/CALML6	13
KEGG	hsa04370	VEGF signaling pathway	7/1360	59/8135	0.8846	1	0.9104	SH2D2A/JMJD7-PLA2G4B/HRAS/HSPB1/PRKCG/AKT1/MAPKAPK3	7
KEGG	hsa04720	Long-term potentiation	8/1360	67/8135	0.8924	1	0.9104	PLCB1/PPP1CA/PLCB3/HRAS/PRKCG/PRKACA/ARAF/CALML6	8
KEGG	hsa04070	Phosphatidylinositol signaling system	12/1360	97/8135	0.9059	1	0.9104	DGKH/DGKZ/PLCB1/PI4K2A/PLCB3/PLCD1/PIP5K1C/PRKCG/PPIP5K1/PTEN/CALML6/PI4KB	12
KEGG	hsa04620	Toll-like receptor signaling pathway	13/1360	104/8135	0.906	1	0.9104	TLR5/MAP2K7/TNF/TAB1/IL12A/CXCL9/TLR4/TLR2/IRF5/CXCL11/RELA/IRAK1/AKT1	13
KEGG	hsa05031	Amphetamine addiction	8/1360	69/8135	0.9099	1	0.9104	CREB3/SLC18A2/PPP1CA/SLC18A1/PRKCG/PRKACA/MAOA/CALML6	8
KEGG	hsa04668	TNF signaling pathway	14/1360	112/8135	0.9128	1	0.9104	RPS6KA4/EDN1/PGAM5/CREB3/MAP2K7/TNF/TRAF2/TAB1/IL18R1/BAG4/RELA/MAP3K14/JUNB/AKT1	14
KEGG	hsa04510	Focal adhesion	27/1360	201/8135	0.9161	1	0.9104	THBS1/ITGA2/PPP1R12C/PPP1CA/ITGA1/ITGA7/VEGFB/ITGB3/ACTG1/EGF/COL6A2/HRAS/PDGFB/PARVG/CCND1/VWF/PIP5K1C/PRKCG/FYN/PDGFC/LAMC1/PAK4/PTEN/AKT1/BCL2/ACTB/HGF	27
KEGG	hsa05217	Basal cell carcinoma	7/1360	63/8135	0.9206	1	0.9104	DVL2/WNT10B/BAX/DDB2/DVL1/BMP4/FZD8	7
KEGG	hsa04012	ErbB signaling pathway	10/1360	85/8135	0.9211	1	0.9104	EIF4EBP1/MAP2K7/RPS6KB2/CDKN1B/EGF/HRAS/PRKCG/PAK4/ARAF/AKT1	10
KEGG	hsa04215	Apoptosis - multiple species	3/1360	32/8135	0.9218	1	0.9104	BBC3/BAX/BCL2	3
KEGG	hsa04380	Osteoclast differentiation	16/1360	128/8135	0.9249	1	0.9104	LILRA4/MAP2K7/TNF/TRAF2/TGFB1/TAB1/ITGB3/SOCS1/SQSTM1/FCGR1A/FYN/CSF1R/RELA/MAP3K14/JUNB/AKT1	16
KEGG	hsa04929	GnRH secretion	7/1360	64/8135	0.9279	1	0.9104	PLCB1/PLCB3/ARRB1/HRAS/PRKCG/AKT1/GPER1	7
KEGG	hsa03440	Homologous recombination	4/1360	41/8135	0.9294	1	0.9104	POLD2/POLD4/BABAM1/RPA1	4
KEGG	hsa04726	Serotonergic synapse	14/1360	115/8135	0.9301	1	0.9104	SLC18A2/PLCB1/CYP2D6/GNGT2/SLC18A1/PLCB3/JMJD7-PLA2G4B/HRAS/PRKCG/PRKACA/MAOA/ARAF/CYP2C8/GNAI2	14
KEGG	hsa04621	NOD-like receptor signaling pathway	24/1360	184/8135	0.9304	1	0.9104	TXN2/ATG16L1/SUGT1/TNF/HSP90AB1/TRAF2/PLCB1/TAB1/TLR4/PKN1/PLCB3/SHARPIN/CASP5/IL18/AIM2/CARD9/NAIP/VDAC2/VDAC1/RELA/NFKBIB/TRPV2/PSTPIP1/BCL2	24
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	28/1360	212/8135	0.9343	1	0.9104	EIF4EBP1/EPHX1/KPNA2/PAQR7/AIP/CREB3/PTGES3/HSP90AB1/RPS6KB2/FGF18/EGF/KLF5/ARRB1/HRAS/KPNA6/KLF4/EPHX3/CCND1/PRKCG/PRKACA/MGST2/E2F1/RELA/GNAI2/RXRB/CYP1B1/AKT1/BCL2	28
KEGG	hsa04979	Cholesterol metabolism	5/1360	50/8135	0.9374	1	0.9104	SCARB1/ABCA1/CETP/VDAC2/VDAC1	5
KEGG	hsa04512	ECM-receptor interaction	10/1360	88/8135	0.939	1	0.9104	THBS1/ITGA2/GP5/ITGA1/ITGA7/ITGB3/SDC1/COL6A2/VWF/LAMC1	10
KEGG	hsa04151	PI3K-Akt signaling pathway	49/1360	354/8135	0.9428	1	0.9104	EIF4EBP1/THBS1/G6PC3/ITGA2/CREB3/IL4R/HSP90AB1/CDC37/RPS6KB2/MLST8/FGF18/CDKN1B/ITGA1/ITGA7/GNGT2/TLR4/VEGFB/PKN1/ITGB3/EGF/EIF4E2/GYS1/COL6A2/PCK2/PPP2R1A/PRL/HRAS/CRTC2/NR4A1/TLR2/CDK4/PDGFB/IRS1/PPP2R5D/CCND1/VWF/PDGFC/LAMC1/TSC2/CSF1R/PTEN/MYB/PPP2R2D/RELA/EPHA2/PKN3/AKT1/BCL2/HGF	49
KEGG	hsa04371	Apelin signaling pathway	17/1360	139/8135	0.9436	1	0.9104	RPS6KB2/PLCB1/HDAC4/GNGT2/RRAS/PLCB3/HRAS/TFAM/CCND1/PRKACA/MEF2D/NRF1/PRKAG3/GNAI2/MEF2B/CALML6/AKT1	17
KEGG	hsa04022	cGMP-PKG signaling pathway	21/1360	167/8135	0.9443	1	0.9104	ADORA1/CREB3/SLC25A5/SLC25A6/PLCB1/PPP1CA/KCNMA1/PLCB3/ATP1A4/NPR2/IRS1/PDE3A/MEF2D/PDE5A/VDAC2/VDAC1/GNAI2/MEF2B/ATP1A3/CALML6/AKT1	21
KEGG	hsa04310	Wnt signaling pathway	21/1360	167/8135	0.9443	1	0.9104	CTNNBIP1/CSNK2B/CSNK1E/SERPINF1/CTBP1/PLCB1/PORCN/CACYBP/PLCB3/DVL2/RUVBL1/ROR2/PPARD/WNT10B/CCND1/PRKCG/PRKACA/DVL1/FZD8/CUL1/DAAM2	21
KEGG	hsa05417	Lipid and atherosclerosis	28/1360	215/8135	0.9448	1	0.9104	ARHGEF1/ABCA1/MAP2K7/TNF/HSP90AB1/TRAF2/PLCB1/XBP1/TAB1/IL12A/TLR4/PLCB3/HRAS/TLR2/CD40LG/DDIT3/BAX/IL18/POU2F2/MMP1/CYP2C8/RELA/IRAK1/RXRB/CALML6/AKT1/BCL2/AGER	28
KEGG	hsa00430	Taurine and hypotaurine metabolism	1/1360	16/8135	0.9466	1	0.9104	GGT7	1
KEGG	hsa04950	Maturity onset diabetes of the young	2/1360	26/8135	0.9468	1	0.9104	HHEX/GCK	2
KEGG	hsa04935	Growth hormone synthesis, secretion and action	14/1360	119/8135	0.9486	1	0.9104	CREB3/PLCB1/SOCS1/PLCB3/SOCS2/HRAS/IRS1/PRKCG/PRKACA/SSTR2/GNAI2/JUNB/AKT1/IGFBP3	14
KEGG	hsa00600	Sphingolipid metabolism	5/1360	52/8135	0.95	1	0.9104	HEXA/PSAP/CERS3/CERK/SMPD1	5
KEGG	hsa05161	Hepatitis B	20/1360	162/8135	0.9511	1	0.9104	CCNA1/CREB3/MAP2K7/TNF/TGFB1/TAB1/TLR4/HRAS/TLR2/EGR2/PRKCG/BAX/E2F1/DDB2/DDB1/ARAF/RELA/IRAK1/AKT1/BCL2	20
KEGG	hsa04140	Autophagy - animal	17/1360	141/8135	0.9512	1	0.9104	ATG4B/VAMP8/ATG14/ATG16L1/RPS6KB2/MLST8/AKT1S1/ATG4D/RRAS/HRAS/IRS1/SQSTM1/PRKACA/TSC2/PTEN/AKT1/BCL2	17
KEGG	hsa04613	Neutrophil extracellular trap formation	24/1360	190/8135	0.9521	1	0.9104	CR1/SLC25A5/SLC25A6/PLCB1/HDAC8/HDAC4/TLR4/ITGB3/ACTG1/PLCB3/HDAC3/CR1L/HDAC10/TLR2/HDAC6/VWF/FCGR1A/PRKCG/VDAC2/VDAC1/RELA/AKT1/ACTB/AGER	24
KEGG	hsa05133	Pertussis	8/1360	76/8135	0.9533	1	0.9104	TNF/IRF8/IL12A/TLR4/RELA/GNAI2/IRAK1/CALML6	8
KEGG	hsa04810	Regulation of actin cytoskeleton	28/1360	218/8135	0.9539	1	0.9104	ARHGEF1/BAIAP2/ARPC5L/ITGA2/PPP1R12C/PFN1/PPP1CA/FGF18/ITGA1/ITGA7/ITGB3/ACTG1/EGF/RRAS/ARPC1A/HRAS/EZR/PDGFB/PIP5K1C/PDGFC/PAK4/ITGAE/ARAF/GIT1/BRK1/ACTB/LIMK2/ARHGEF12	28
KEGG	hsa00512	Mucin type O-glycan biosynthesis	3/1360	36/8135	0.954	1	0.9104	GALNT14/GALNT11/ST6GALNAC4	3
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1360	27/8135	0.9543	1	0.9104	B4GALT3/B3GNT5	2
KEGG	hsa04514	Cell adhesion molecules	18/1360	149/8135	0.9545	1	0.9104	HLA-DMA/HLA-DPB1/HLA-DMB/CD8B/HLA-DPA1/CD8A/CD99/SDC3/CD4/SDC1/ICAM2/MADCAM1/CD40LG/PTPRM/HLA-F/HLA-DRA/MAG/CLDN15	18
KEGG	hsa00910	Nitrogen metabolism	1/1360	17/8135	0.9555	1	0.9104	CA12	1
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	7/1360	69/8135	0.9563	1	0.9104	GSTP1/EPHX1/CBR1/CYP2E1/MGST2/CYP2C8/CYP1B1	7
KEGG	hsa02010	ABC transporters	4/1360	45/8135	0.9566	1	0.9104	ABCA1/ABCA13/ABCD4/ABCB7	4
KEGG	hsa05100	Bacterial invasion of epithelial cells	8/1360	77/8135	0.9576	1	0.9104	MAD2L2/ARPC5L/CLTA/CLTB/ACTG1/ARPC1A/ACTB/DNM3	8
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	18/1360	150/8135	0.9577	1	0.9104	CACNB1/CREB3/CACNA2D4/PLCB1/PPP1CA/PLCB3/KCNE1/PPP2R1A/CACNA2D3/ATP1A4/PPP2R5D/PRKACA/PPP2R2D/GNAI2/ATP1A3/CALML6/AKT1/BCL2	18
KEGG	hsa04926	Relaxin signaling pathway	15/1360	129/8135	0.9589	1	0.9104	EDN1/CREB3/MAP2K7/PLCB1/TGFB1/GNGT2/VEGFB/PLCB3/ARRB1/HRAS/PRKACA/MMP1/RELA/GNAI2/AKT1	15
KEGG	hsa04610	Complement and coagulation cascades	9/1360	85/8135	0.9592	1	0.9104	C3AR1/SERPINF2/CR1/F5/CR1L/VWF/PROS1/F13A1/CD59	9
KEGG	hsa03460	Fanconi anemia pathway	5/1360	54/8135	0.9603	1	0.9104	TELO2/ERCC1/REV1/FANCF/RPA1	5
KEGG	hsa04970	Salivary secretion	10/1360	93/8135	0.961	1	0.9104	VAMP2/CST3/PLCB1/KCNMA1/PLCB3/ATP1A4/PRKCG/PRKACA/ATP1A3/CALML6	10
KEGG	hsa04657	IL-17 signaling pathway	10/1360	94/8135	0.9644	1	0.9104	TRAF4/TNF/HSP90AB1/TRAF2/IL17RC/ELAVL1/IL17RE/MMP1/RELA/S100A7	10
KEGG	hsa00982	Drug metabolism - cytochrome P450	7/1360	72/8135	0.9681	1	0.9104	GSTP1/CYP2D6/CYP2E1/ADH5/MGST2/MAOA/CYP2C8	7
KEGG	hsa04923	Regulation of lipolysis in adipocytes	5/1360	56/8135	0.9686	1	0.9104	ADORA1/IRS1/PRKACA/GNAI2/AKT1	5
KEGG	hsa05224	Breast cancer	17/1360	147/8135	0.969	1	0.9104	RPS6KB2/FGF18/EGF/DVL2/HRAS/CDK4/NOTCH4/WNT10B/CCND1/BAX/E2F1/DDB2/DVL1/ARAF/PTEN/FZD8/AKT1	17
KEGG	hsa04927	Cortisol synthesis and secretion	6/1360	65/8135	0.9714	1	0.9104	SCARB1/CREB3/PLCB1/PLCB3/NR4A1/PRKACA	6
KEGG	hsa04725	Cholinergic synapse	12/1360	113/8135	0.9752	1	0.9104	CREB3/PLCB1/GNGT2/PLCB3/HRAS/KCNJ2/PRKCG/FYN/PRKACA/GNAI2/AKT1/BCL2	12
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	10/1360	98/8135	0.9756	1	0.9104	PLCB1/PPP1CA/P2RY2/PLCB3/JMJD7-PLA2G4B/PRKCG/PRKACA/ASIC3/CALML6/TRPV2	10
KEGG	hsa04925	Aldosterone synthesis and secretion	10/1360	98/8135	0.9756	1	0.9104	SCARB1/CREB3/PLCB1/PLCB3/NR4A1/ATP1A4/PRKCG/PRKACA/ATP1A3/CALML6	10
KEGG	hsa05032	Morphine addiction	9/1360	91/8135	0.9773	1	0.9104	ADORA1/GNGT2/ARRB1/PRKCG/PDE3A/PRKACA/PDE1A/GRK4/GNAI2	9
KEGG	hsa04724	Glutamatergic synapse	12/1360	114/8135	0.9774	1	0.9104	PLD2/PLCB1/DLG4/GNGT2/PLCB3/JMJD7-PLA2G4B/PRKCG/PRKACA/GRM2/GNAI2/GLS2/SLC1A3	12
KEGG	hsa04664	Fc epsilon RI signaling pathway	6/1360	68/8135	0.9797	1	0.9104	MAP2K7/TNF/JMJD7-PLA2G4B/HRAS/FYN/AKT1	6
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/1360	100/8135	0.9799	1	0.9104	XCL2/TNF/CXCL9/IL10RA/IL18R1/IL18/CXCL11/XCL1/CSF1R/CXCL13	10
KEGG	hsa04915	Estrogen signaling pathway	15/1360	138/8135	0.9803	1	0.9104	CREB3/FKBP5/HSP90AB1/FKBP4/PLCB1/KRT10/PLCB3/HRAS/KRT18/PRKACA/GNAI2/CALML6/AKT1/BCL2/GPER1	15
KEGG	hsa04974	Protein digestion and absorption	10/1360	103/8135	0.9851	1	0.9104	COL5A1/SLC3A2/COL6A2/COL11A2/SLC1A5/COL18A1/ATP1A4/COL26A1/COL17A1/ATP1A3	10
KEGG	hsa05202	Transcriptional misregulation in cancer	22/1360	193/8135	0.9856	1	0.9104	MEN1/CCNA1/ASPSCR1/HHEX/SPINT1/CDKN1B/ID2/CDK14/PRCC/CDK9/IL1R2/DDIT3/FCGR1A/BAX/DDB2/SS18L1/BAIAP3/CSF1R/RELA/RXRB/EWSR1/IGFBP3	22
KEGG	hsa05150	Staphylococcus aureus infection	9/1360	96/8135	0.9864	1	0.9104	C3AR1/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DPA1/KRT10/KRT18/FCGR1A/HLA-DRA	9
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/1360	143/8135	0.9873	1	0.9104	ID3/PCGF1/ID2/DVL2/PCGF6/HRAS/KLF4/WNT10B/DVL1/BMP4/PCGF3/FZD8/ID1/INHBB/AKT1	15
KEGG	hsa04977	Vitamin digestion and absorption	1/1360	24/8135	0.9877	1	0.9104	SCARB1	1
KEGG	hsa05163	Human cytomegalovirus infection	26/1360	225/8135	0.9888	1	0.9104	EIF4EBP1/ARHGEF1/CREB3/CALR/TNF/RPS6KB2/TRAF2/PLCB1/GNGT2/ITGB3/PLCB3/IL10RA/HRAS/CDK4/CCND1/PRKCG/HLA-F/PRKACA/BAX/E2F1/TSC2/RELA/GNAI2/CALML6/AKT1/ARHGEF12	26
KEGG	hsa04662	B cell receptor signaling pathway	7/1360	82/8135	0.9894	1	0.9104	LILRA4/CD81/NFKBIE/HRAS/RELA/NFKBIB/AKT1	7
KEGG	hsa04912	GnRH signaling pathway	8/1360	93/8135	0.9922	1	0.9104	PLD2/MAP2K7/PLCB1/PLCB3/JMJD7-PLA2G4B/HRAS/PRKACA/CALML6	8
KEGG	hsa04966	Collecting duct acid secretion	1/1360	27/8135	0.9929	1	0.9104	ATP6V1F	1
KEGG	hsa04742	Taste transduction	7/1360	86/8135	0.9934	1	0.9104	PLCB1/SCN9A/P2RY1/PLCB3/PRKACA/PDE1A/TAS2R3	7
KEGG	hsa04360	Axon guidance	19/1360	182/8135	0.9942	1	0.9104	PLXNA4/SEMA3G/EFNB1/RRAS/PLXNB3/HRAS/SRGAP1/ABLIM2/ROBO3/CDK5/SEMA4C/FYN/PARD3/PAK4/SEMA6B/GNAI2/EPHA2/LIMK2/ARHGEF12	19
KEGG	hsa04713	Circadian entrainment	8/1360	97/8135	0.9951	1	0.9104	RASD1/PLCB1/GNGT2/PLCB3/PRKCG/PRKACA/GNAI2/CALML6	8
KEGG	hsa05168	Herpes simplex virus 1 infection	63/1360	495/8135	0.9952	1	0.9104	EIF4EBP1/ZNF34/ALYREF/CD74/HLA-DMA/HLA-DPB1/CALR/EIF2B4/TNF/HLA-DMB/ZNF124/EIF2B1/ZNF256/ZNF205/HLA-DPA1/TRAF2/ZNF284/PPP1CA/ZNF331/ZNF548/TAB1/IL12A/ZNF785/ITGB3/ZFP69/PILRB/ZNF74/ZNF777/ZNF184/TLR2/ZNF14/ZNF627/ZNF211/HLA-F/HLA-DRA/ZNF599/ZNF251/ZNF671/ZNF570/BAX/SRSF2/CARD9/ZNF3/ZNF529/ZNF773/TSC2/SRSF9/CFP/POU2F2/ZNF766/ZNF534/ZNF688/EIF2AK2/ZNF233/RELA/IRAK1/ZNF749/EIF2B3/ZFP37/ZNF700/AKT1/BCL2/ZNF717	63
KEGG	hsa04976	Bile secretion	7/1360	89/8135	0.9954	1	0.9104	EPHX1/SCARB1/SCT/ATP1A4/PRKACA/SLC51A/ATP1A3	7
KEGG	hsa04114	Oocyte meiosis	12/1360	131/8135	0.9957	1	0.9104	MAD2L2/ANAPC11/ANAPC2/PPP1CA/CPEB3/MAD1L1/PPP2R1A/PPP2R5D/ANAPC15/PRKACA/CUL1/CALML6	12
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	12/1360	131/8135	0.9957	1	0.9104	HCST/TNF/ICAM2/HRAS/ZAP70/NCR3/PRKCG/CD244/FYN/ARAF/CD48/SH2D1A	12
KEGG	hsa04014	Ras signaling pathway	25/1360	232/8135	0.9963	1	0.9104	PLD2/RASAL3/FGF18/GNGT2/VEGFB/EGF/RRAS/ARF6/JMJD7-PLA2G4B/HRAS/PDGFB/RASGRP2/ZAP70/PRKCG/PRKACA/PDGFC/PAK4/PLA2G5/CSF1R/RIN1/RELA/CALML6/EPHA2/AKT1/HGF	25
KEGG	hsa04972	Pancreatic secretion	8/1360	102/8135	0.9972	1	0.9104	SCT/PLCB1/KCNMA1/PLCB3/ATP1A4/PRKCG/PLA2G5/ATP1A3	8
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	4/1360	66/8135	0.9974	1	0.9104	PSTK/FARSA/TARS2/SARS2	4
KEGG	hsa04062	Chemokine signaling pathway	19/1360	192/8135	0.9976	1	0.9104	XCL2/PLCB1/CXCL9/GNGT2/PLCB3/ARRB1/HRAS/RASGRP2/PARD3/PRKACA/CXCL11/GRK4/XCL1/CXCL13/RELA/GNAI2/NFKBIB/AKT1/GSK3A	19
KEGG	hsa04630	JAK-STAT signaling pathway	15/1360	162/8135	0.9979	1	0.9104	IL4R/PIAS4/IL27RA/IL12A/SOCS1/EGF/IL10RA/SOCS2/PRL/HRAS/PDGFB/CCND1/IL21R/AKT1/BCL2	15
KEGG	hsa04020	Calcium signaling pathway	25/1360	240/8135	0.9981	1	0.9104	CACNA1E/SLC25A5/PHKG2/SLC25A6/PLCB1/FGF18/VEGFB/EGF/PLCB3/PLCD1/ORAI2/PDGFB/PRKCG/PRKACA/PDGFC/ASPH/GNAL/PDE1A/TPCN1/LTB4R2/VDAC2/VDAC1/MCOLN3/CALML6/HGF	25
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/1360	70/8135	0.9985	1	0.9104	ATP6V1F/GIT1/RELA/MAP3K14	4
KEGG	hsa05034	Alcoholism	17/1360	187/8135	0.9991	1	0.9104	CREB3/SLC18A2/HDAC8/PPP1CA/HDAC4/GNGT2/SLC18A1/HDAC3/HRAS/SLC29A3/HDAC10/HDAC6/PRKACA/MAOA/ARAF/GNAI2/CALML6	17
KEGG	hsa04060	Cytokine-cytokine receptor interaction	31/1360	295/8135	0.9992	1	0.9104	CLCF1/IL4R/XCL2/TNF/TNFSF9/EDA/IL27RA/TGFB1/IL12A/CXCL9/IL17RC/CD4/IL10RA/PRL/IL18R1/CD40LG/IL32/IL1R2/TNFRSF25/IL18/TNFSF12/CXCL11/IL17RE/BMP4/XCL1/CSF1R/IL21R/CXCL13/TNFRSF21/INHBB/IL1RN	31
KEGG	hsa04670	Leukocyte transendothelial migration	8/1360	114/8135	0.9994	1	0.9104	CD99/ACTG1/CTNND1/EZR/PRKCG/GNAI2/ACTB/CLDN15	8
KEGG	hsa04727	GABAergic synapse	5/1360	89/8135	0.9996	1	0.9104	GNGT2/PRKCG/PRKACA/GNAI2/GLS2	5
KEGG	hsa05322	Systemic lupus erythematosus	10/1360	136/8135	0.9996	1	0.9104	HLA-DMA/SNRPB/HLA-DPB1/TNF/HLA-DMB/HLA-DPA1/CD40LG/FCGR1A/HLA-DRA/SNRPD1	10
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/1360	194/8135	0.9998	1	0.9104	ATG14/MAP2K7/UBA52/TRAF2/GNGT2/HRAS/CDK4/PDGFB/CCND1/HLA-F/BAX/E2F1/EIF2AK2/RELA/CALML6/AKT1	16
KEGG	hsa04024	cAMP signaling pathway	19/1360	221/8135	0.9999	1	0.9104	ADORA1/EDN1/PLD2/CREB3/PPP1CA/RRAS/ATP1A4/ACOX3/HCAR2/PDE3A/PRKACA/SUCNR1/HCAR3/SSTR2/RELA/GNAI2/ATP1A3/CALML6/AKT1	19
KEGG	hsa05206	MicroRNAs in cancer	27/1360	310/8135	1	1	0.9104	THBS1/UBE2I/SOX4/FSCN1/HMOX1/CDKN1B/BMF/HDAC4/ITGB3/SOCS1/HRAS/CDC25B/DNMT1/EZR/CYP24A1/PDGFB/NOTCH4/IRS1/CCND1/PRKCG/SPRY2/PAK4/E2F1/PTEN/GLS2/CYP1B1/BCL2	27
KEGG	hsa04080	Neuroactive ligand-receptor interaction	21/1360	353/8135	1	1	0.9104	ADORA1/C3AR1/EDN1/SCT/PTGIR/GPR35/S1PR5/NMB/ADM2/P2RY2/P2RY1/PRL/GZMA/PARD3/SSTR2/NMUR1/AVPR2/LTB4R2/GRM2/THRA/AVP	21
KEGG	hsa04740	Olfactory transduction	7/1360	440/8135	1	1	0.9104	ARRB1/PRKACA/GNAL/PDE1A/NCALD/CALML6/OR52N2	7