ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa03040 Spliceosome 33/692 147/8135 1.543e-07 4.905e-05 4.563e-05 HNRNPA1L2/SF3A2/BCAS2/SLU7/XAB2/LSM6/CCDC12/SF3A1/SNRPF/SRSF2/TCERG1/DHX8/LSM7/RBMX/SF3B5/SNRPB/SRSF3/RBM25/DHX16/PRPF38A/SNRPA/RP9/PHF5A/BUD31/TRA2B/SF3B2/SF3B4/SRSF7/CDC40/RBM17/CWC15/PUF60/HNRNPC 33 KEGG hsa05168 Herpes simplex virus 1 infection 71/692 495/8135 5.783e-06 0.0009195 0.0008553 ZNF718/ZNF155/ZNF7/ZNF689/ZNF746/ZNF208/ZNF404/ZNF578/ZNF8/ZNF12/ZNF419/FADD/ZNF570/BAK1/ZNF333/HLA-G/ZNF432/ZNF552/SRSF2/PIK3CA/HLA-DRB1/HLA-B/ZNF766/ZNF546/ZNF805/ZNF777/TNFRSF14/HLA-C/ZNF829/ZNF211/ZNF761/ZNF549/ZNF791/ZNF461/ZNF420/ZNF45/ZNF331/ZNF415/ZNF793/ZNF729/SRSF3/NFKBIA/ZNF836/ZNF529/EIF2B5/ZNF160/CASP9/ZNF212/PIK3R1/ZNF234/ZNF283/IL12A/ZNF669/ZNF33B/HLA-DQA1/ZNF780B/ZNF257/HLA-E/ZNF780A/ZNF562/ZNF583/ZNF568/ZNF383/SRSF7/ZNF514/PIK3CD/C5/TRAF3/ZNF707/ZNF607/ZNF616 71 KEGG hsa05169 Epstein-Barr virus infection 33/692 202/8135 0.0001842 0.01953 0.01816 NFKBIE/GADD45A/MAP3K14/CIR1/FADD/BAK1/TNFAIP3/NFKB2/HLA-G/PIK3CA/HLA-DRB1/CCND1/HLA-B/CDKN1B/RELB/CDK4/HLA-C/PSMD6/NCOR2/ADRM1/CDKN1A/NFKBIA/NFKBIB/PSMC5/CASP9/PIK3R1/MAP2K7/PSMD7/HLA-DQA1/HLA-E/PIK3CD/TRAF3/ENTPD1 33 KEGG hsa03013 Nucleocytoplasmic transport 20/692 108/8135 0.0006784 0.05393 0.05016 RAE1/TNPO2/NUP50/EEF1A2/NUP153/SAP18/NUP133/DDX19B/SUMO3/UPF1/NUP35/UBE2I/NUP93/KPNA5/SENP2/GLE1/NUP155/IPO13/SUMO4/KPNA2 20 KEGG hsa05016 Huntington disease 42/692 306/8135 0.001219 0.07752 0.07211 POLR2D/POLR2J3/UQCRFS1/PSMB6/NRBF2/DCTN4/NRF1/NDUFS1/POLR2J/ATG14/TBPL1/NDUFA7/POLR2C/COX8A/PSMD6/CLTB/TUBA4A/TUBB2A/COX5B/ADRM1/TUBA1A/PSMD9/PPIF/DCTN5/PSMC5/CASP9/MAP2K7/CYC1/SLC25A6/TUBB6/IFT57/PSMD7/DCTN3/ATG2A/NDUFA11/POLR2F/TUBB1/SDHC/DCTN6/SDHD/NDUFS3/CREBBP 42 KEGG hsa04668 TNF signaling pathway 19/692 112/8135 0.002662 0.1356 0.1261 IRF1/MAP3K14/JUNB/ATF4/FADD/TNFAIP3/PIK3CA/CASP7/NFKBIA/CASP10/PIK3R1/MAP2K7/CFLAR/MMP14/BAG4/BCL3/PIK3CD/RPS6KA5/TRAF3 19 KEGG hsa04115 p53 signaling pathway 14/692 73/8135 0.002984 0.1356 0.1261 GADD45A/SIVA1/PMAIP1/CHEK2/CCND1/TNFRSF10B/CDK4/GORAB/CCNG1/CDKN1A/CCNG2/THBS1/CASP9/PPM1D 14 KEGG hsa04146 Peroxisome 15/692 82/8135 0.003469 0.1379 0.1283 PEX16/PEX10/PEX12/DHRS4/PXMP4/PEX7/MPV17/PEX6/ACOX2/PEX14/ACAA1/MPV17L2/PRDX5/EHHADH/ACSL3 15 KEGG hsa04210 Apoptosis 21/692 136/8135 0.005198 0.163 0.1517 GADD45A/MAP3K14/PMAIP1/ATF4/FADD/BAK1/PIK3CA/CTSW/TNFRSF10B/TUBA4A/CASP7/TUBA1A/NFKBIA/CASP10/CASP9/PIK3R1/RAF1/CFLAR/PIK3CD/DFFA/ENDOG 21 KEGG hsa04130 SNARE interactions in vesicular transport 8/692 33/8135 0.00538 0.163 0.1517 VAMP3/STX8/STX5/YKT6/GOSR1/VAMP5/BNIP1/BET1L 8 KEGG hsa04660 T cell receptor signaling pathway 17/692 104/8135 0.006407 0.163 0.1517 NFKBIE/MAP3K14/PIK3CA/CDK4/BCL10/ITK/NCK1/NFKBIA/PPP3R1/NFKBIB/PIK3R1/MAP2K7/RAF1/CBLB/PIK3CD/PRKCQ/LCK 17 KEGG hsa03020 RNA polymerase 8/692 34/8135 0.006523 0.163 0.1517 POLR2D/POLR2J3/CRCP/POLR2J/POLR2C/TWISTNB/POLR3C/POLR2F 8 KEGG hsa05166 Human T-cell leukemia virus 1 infection 30/692 222/8135 0.007254 0.163 0.1517 MAP3K14/ATF4/CHEK2/EGR2/NFKB2/ADCY7/HLA-G/PIK3CA/HLA-DRB1/CCND1/HLA-B/TBPL1/RELB/CDK4/HLA-C/SLC2A1/ZFP36/MAP3K3/CDKN1A/NFKBIA/PPP3R1/PIK3R1/SLC25A6/ETS2/HLA-DQA1/HLA-E/CRTC2/PIK3CD/CREBBP/LCK 30 KEGG hsa05203 Viral carcinogenesis 28/692 204/8135 0.007553 0.163 0.1517 PMAIP1/ATF4/BAK1/EGR2/NFKB2/HLA-G/PIK3CA/CCND1/HLA-B/TBPL1/CDKN1B/CDK4/HLA-C/GTF2A2/CDKN1A/GTF2B/NFKBIA/REL/MAPKAPK2/YWHAG/PIK3R1/HDAC4/HLA-E/GTF2A1/PIK3CD/SND1/CREBBP/TRAF3 28 KEGG hsa05134 Legionellosis 11/692 57/8135 0.007691 0.163 0.1517 SAR1A/EEF1A2/NFKB2/CASP7/ARF1/NFKBIA/CR1/CASP9/IL12A/HSF1/NAIP 11 KEGG hsa05014 Amyotrophic lateral sclerosis 44/692 364/8135 0.01039 0.2065 0.1921 UQCRFS1/HNRNPA1L2/PSMB6/NRBF2/DCTN4/RAE1/ATF4/NUP50/NDUFS1/NUP153/NUP133/ATG14/SMCR8/NDUFA7/COX8A/PSMD6/TUBA4A/TUBB2A/NUP35/COX5B/NUP93/CHMP2B/ADRM1/TUBA1A/PSMD9/SRSF3/PPP3R1/DCTN5/PSMC5/CASP9/CYC1/TUBB6/PSMD7/DCTN3/ATG2A/NDUFA11/TUBB1/SDHC/DCTN6/SDHD/SRSF7/NDUFS3/GLE1/NUP155 44 KEGG hsa05132 Salmonella infection 32/692 249/8135 0.0117 0.2142 0.1992 ABI1/DCTN4/MYL5/DYNLT1/RHOH/FADD/BAK1/PIK3CA/DNM2/TNFRSF10B/RAB9A/VPS18/TUBA4A/CASP7/TUBB2A/TUBA1A/RPS3/ARF1/NFKBIA/EXOC7/DCTN5/CTNNB1/MAP2K7/RAF1/TUBB6/DCTN3/PLEKHM2/TUBB1/DCTN6/PIK3CD/VPS39/NAIP 32 KEGG hsa03022 Basal transcription factors 9/692 45/8135 0.01212 0.2142 0.1992 TAF13/CDK7/TBPL1/TAF9/GTF2A2/GTF2B/TAF10/TAF5/GTF2A1 9 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 26/692 194/8135 0.01318 0.2207 0.2053 MICA/FADD/BAK1/MICB/HLA-G/PIK3CA/ATG14/CCND1/HLA-B/CDK4/HLA-C/ZFP36/CDKN1A/NFKBIA/PPP3R1/MAPKAPK2/GNG4/CASP9/CTNNB1/PIK3R1/MAP2K7/RAF1/HLA-E/PIK3CD/CREBBP/TRAF3 26 KEGG hsa04625 C-type lectin receptor signaling pathway 16/692 104/8135 0.01416 0.2212 0.2057 IRF1/MAP3K14/EGR2/NFKB2/PIK3CA/RELB/BCL10/NFKBIA/PPP3R1/MAPKAPK2/PIK3R1/RAF1/IL12A/CBLB/BCL3/PIK3CD 16 KEGG hsa04068 FoxO signaling pathway 19/692 131/8135 0.01461 0.2212 0.2057 GADD45A/PRKAB1/FBXO32/CDKN2D/KLF2/BCL6/PIK3CA/CCND1/CDKN1B/CDKN1A/PLK4/CSNK1E/GABARAPL1/CCNG2/PIK3R1/RAF1/G6PC3/PIK3CD/CREBBP 19 KEGG hsa01524 Platinum drug resistance 12/692 73/8135 0.01936 0.2799 0.2603 GSTT1/PMAIP1/FADD/GSTM4/BAK1/PIK3CA/GSTP1/CDKN1A/ATP7A/CASP9/PIK3R1/PIK3CD 12 KEGG hsa05222 Small cell lung cancer 14/692 92/8135 0.02281 0.294 0.2735 GADD45A/TRAF4/BAK1/PIK3CA/CCND1/CDKN1B/CDK4/ZBTB17/CDKN1A/NFKBIA/CASP9/PIK3R1/PIK3CD/TRAF3 14 KEGG hsa05213 Endometrial cancer 10/692 58/8135 0.0231 0.294 0.2735 GADD45A/BAK1/PIK3CA/CCND1/CDKN1A/CASP9/CTNNB1/PIK3R1/RAF1/PIK3CD 10 KEGG hsa04722 Neurotrophin signaling pathway 17/692 119/8135 0.02312 0.294 0.2735 NFKBIE/ATF4/ZNF274/PIK3CA/CAMK2D/MAP3K3/NFKBIA/NFKBIB/MAPKAPK2/PIK3R1/MAP2K7/RAF1/SH2B3/FRS2/PRDM4/PIK3CD/RPS6KA5 17 KEGG hsa05010 Alzheimer disease 44/692 384/8135 0.02456 0.3004 0.2794 UQCRFS1/PSMB6/NRBF2/NCSTN/ATF4/HSD17B10/NDUFS1/FADD/FRAT1/PIK3CA/ATG14/NDUFA7/FRAT2/COX8A/PSMD6/TUBA4A/CASP7/TUBB2A/COX5B/FZD6/ADRM1/TUBA1A/PSMD9/CSNK1E/PPP3R1/PPIF/PSMC5/CASP9/CTNNB1/PIK3R1/MAP2K7/CYC1/RAF1/SLC25A6/TUBB6/PSMD7/ATG2A/NDUFA11/TUBB1/DVL2/SDHC/SDHD/PIK3CD/NDUFS3 44 KEGG hsa04012 ErbB signaling pathway 13/692 85/8135 0.02662 0.3135 0.2916 AREG/PIK3CA/CDKN1B/CAMK2D/CDKN1A/NCK1/PIK3R1/MAP2K7/RAF1/CBLB/HBEGF/TGFA/PIK3CD 13 KEGG hsa05210 Colorectal cancer 13/692 86/8135 0.02902 0.3296 0.3065 GADD45A/AREG/PMAIP1/BAK1/PIK3CA/CCND1/CDKN1A/CASP9/CTNNB1/PIK3R1/RAF1/TGFA/PIK3CD 13 KEGG hsa05164 Influenza A 22/692 171/8135 0.03241 0.3532 0.3285 RAE1/DNAJB1/FADD/BAK1/PIK3CA/HLA-DRB1/TNFRSF10B/CDK4/HNRNPUL1/NFKBIA/KPNA5/NFKBIB/CASP9/PIK3R1/RAF1/SLC25A6/IL12A/HLA-DQA1/PIK3CD/CREBBP/TRAF3/KPNA2 22 KEGG hsa05215 Prostate cancer 14/692 97/8135 0.03429 0.3532 0.3285 ATF4/PIK3CA/CCND1/CDKN1B/GSTP1/CDKN1A/NFKBIA/CASP9/CTNNB1/PIK3R1/RAF1/TGFA/PIK3CD/CREBBP 14 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 52/692 476/8135 0.03443 0.3532 0.3285 UQCRFS1/PSMB6/NRBF2/DCTN4/ATF4/ATXN1L/HSD17B10/NDUFS1/FADD/BAK1/FRAT1/ATG14/SMCR8/NDUFA7/CAMK2D/FRAT2/UBE2J1/COX8A/PSMD6/TUBA4A/CASP7/TUBB2A/COX5B/CHMP2B/FZD6/ADRM1/TUBA1A/PSMD9/CSNK1E/PPP3R1/PPIF/DCTN5/PSMC5/CASP9/CTNNB1/MAP2K7/CYC1/RAF1/SLC25A6/TUBB6/IFT57/PSMD7/DCTN3/ATG2A/NDUFA11/TUBB1/DVL2/SDHC/DCTN6/SDHD/PRNP/NDUFS3 52 KEGG hsa00020 Citrate cycle (TCA cycle) 6/692 30/8135 0.03774 0.3611 0.3358 DLST/SDHC/SDHD/MDH2/DLD/PDHA1 6 KEGG hsa05020 Prion disease 32/692 273/8135 0.03831 0.3611 0.3358 UQCRFS1/PSMB6/ATF4/NDUFS1/PIK3CA/NDUFA7/COX8A/PSMD6/TUBA4A/TUBB2A/COX5B/ADRM1/TUBA1A/PSMD9/PPP3R1/NCF1/PPIF/PSMC5/CASP9/PIK3R1/CYC1/SLC25A6/TUBB6/PSMD7/NDUFA11/TUBB1/SDHC/SDHD/PRNP/PIK3CD/NDUFS3/C5 32 KEGG hsa05330 Allograft rejection 7/692 38/8135 0.03868 0.3611 0.3358 HLA-G/HLA-DRB1/HLA-B/HLA-C/IL12A/HLA-DQA1/HLA-E 7 KEGG hsa05223 Non-small cell lung cancer 11/692 72/8135 0.03974 0.3611 0.3358 GADD45A/BAK1/PIK3CA/CCND1/CDK4/CDKN1A/CASP9/PIK3R1/RAF1/TGFA/PIK3CD 11 KEGG hsa00562 Inositol phosphate metabolism 11/692 73/8135 0.04336 0.383 0.3562 PI4K2A/PIK3CA/MTMR14/MTMR2/PLCH2/IPPK/INPP5K/PIP4K2C/PIK3CD/PI4KA/INPP5E 11 KEGG hsa00260 Glycine, serine and threonine metabolism 7/692 40/8135 0.04939 0.4245 0.3948 SARDH/PSPH/GNMT/CTH/SDSL/PGAM4/DLD 7 KEGG hsa05214 Glioma 11/692 75/8135 0.05125 0.4289 0.3989 GADD45A/BAK1/PIK3CA/CCND1/CDK4/CAMK2D/CDKN1A/PIK3R1/RAF1/TGFA/PIK3CD 11 KEGG hsa05219 Bladder cancer 7/692 41/8135 0.05538 0.4308 0.4007 CCND1/CDK4/CDKN1A/THBS1/RAF1/HBEGF/RPS6KA5 7 KEGG hsa05212 Pancreatic cancer 11/692 76/8135 0.05554 0.4308 0.4007 GADD45A/BAK1/PIK3CA/CCND1/CDK4/CDKN1A/CASP9/PIK3R1/RAF1/TGFA/PIK3CD 11 KEGG hsa05220 Chronic myeloid leukemia 11/692 76/8135 0.05554 0.4308 0.4007 GADD45A/BAK1/PIK3CA/CCND1/CDKN1B/CDK4/CDKN1A/NFKBIA/PIK3R1/RAF1/PIK3CD 11 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 5/692 26/8135 0.0647 0.464 0.4316 PIGA/GPAA1/MPPE1/PIGO/PIGT 5 KEGG hsa04920 Adipocytokine signaling pathway 10/692 69/8135 0.06549 0.464 0.4316 NFKBIE/PRKAB1/ADIPOR1/SLC2A1/NFKBIA/NFKBIB/CPT1A/ACSL3/G6PC3/PRKCQ 10 KEGG hsa05211 Renal cell carcinoma 10/692 69/8135 0.06549 0.464 0.4316 PIK3CA/SLC2A1/CDKN1A/EGLN3/PIK3R1/RAF1/VHL/TGFA/PIK3CD/CREBBP 10 KEGG hsa05012 Parkinson disease 30/692 266/8135 0.06646 0.464 0.4316 UQCRFS1/PSMB6/ATF4/NDUFS1/DUSP1/NDUFA7/CAMK2D/UBE2J1/COX8A/PSMD6/TUBA4A/TUBB2A/NFE2L2/COX5B/ADRM1/TUBA1A/PSMD9/DRD1/PPIF/PSMC5/CASP9/CYC1/SLC25A6/TUBB6/PSMD7/NDUFA11/TUBB1/SDHC/SDHD/NDUFS3 30 KEGG hsa04940 Type I diabetes mellitus 7/692 43/8135 0.06866 0.464 0.4316 HLA-G/HLA-DRB1/HLA-B/HLA-C/IL12A/HLA-DQA1/HLA-E 7 KEGG hsa03018 RNA degradation 11/692 79/8135 0.06981 0.464 0.4316 BTG2/DDX6/DCP1A/LSM6/C1D/LSM7/PABPC3/BTG3/LSM1/PATL1/EXOSC7 11 KEGG hsa04150 mTOR signaling pathway 19/692 156/8135 0.07005 0.464 0.4316 SLC3A2/AKT1S1/TELO2/GRB10/PIK3CA/ATP6V1G1/LAMTOR3/FZD6/LAMTOR1/WDR24/SLC38A9/PIK3R1/RAF1/ATP6V1E1/RICTOR/DVL2/LAMTOR5/ATP6V1F/PIK3CD 19 KEGG hsa04380 Osteoclast differentiation 16/692 128/8135 0.07584 0.4922 0.4578 MAP3K14/JUNB/JUND/FOSB/NFKB2/PIK3CA/RELB/NFKBIA/PPP3R1/NCF1/PIK3R1/MAP2K7/TNFRSF11B/FOSL2/PIK3CD/LCK 16 KEGG hsa05162 Measles 17/692 139/8135 0.08077 0.5131 0.4773 CD46/FADD/BAK1/TNFAIP3/PIK3CA/CCND1/CDKN1B/RAB9A/CDK4/NFKBIA/NFKBIB/CASP9/PIK3R1/IL12A/CBLB/PIK3CD/TRAF3 17 KEGG hsa05218 Melanoma 10/692 72/8135 0.08248 0.5131 0.4773 GADD45A/BAK1/PIK3CA/CCND1/CDK4/FGF9/CDKN1A/PIK3R1/RAF1/PIK3CD 10 KEGG hsa03250 Viral life cycle - HIV-1 9/692 63/8135 0.0839 0.5131 0.4773 CCNT1/CXCR4/NUP153/TSG101/FURIN/SUPT4H1/CREBBP/CDK9/CHMP4B 9 KEGG hsa05216 Thyroid cancer 6/692 37/8135 0.08979 0.5241 0.4875 GADD45A/BAK1/CCND1/CDKN1A/CCDC6/CTNNB1 6 KEGG hsa03050 Proteasome 7/692 46/8135 0.09187 0.5241 0.4875 PSMB6/PSMD6/ADRM1/PSMD9/PSMC5/PSMD7/PSME4 7 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 25/692 223/8135 0.09259 0.5241 0.4875 UQCRFS1/MAP3K14/GSTT1/NDUFS1/GSTM4/PIK3CA/NDUFA7/COX8A/NFE2L2/COX5B/NFKBIA/NCF1/PPIF/PIK3R1/MAP2K7/CYC1/RAF1/SLC25A6/NDUFA11/SDHC/SLC26A2/SDHD/PIK3CD/NDUFS3/AKR1C1 25 KEGG hsa04630 JAK-STAT signaling pathway 19/692 162/8135 0.09365 0.5241 0.4875 CISH/PIM1/IL21R/PIK3CA/CCND1/SOCS4/OSM/EPOR/CDKN1A/SOCS2/STAM/PIK3R1/RAF1/IL12A/IL13/IL20/CNTF/PIK3CD/CREBBP 19 KEGG hsa04145 Phagosome 18/692 152/8135 0.09395 0.5241 0.4875 ATP6V0C/HLA-G/HLA-DRB1/HLA-B/ATP6V1G1/VAMP3/HLA-C/TUBA4A/TUBB2A/TUBA1A/NCF1/THBS1/TUBB6/ATP6V1E1/HLA-DQA1/HLA-E/TUBB1/ATP6V1F 18 KEGG hsa05017 Spinocerebellar ataxia 17/692 143/8135 0.09873 0.5413 0.5035 PSMB6/NRBF2/ATXN1L/PIK3CA/ATG14/TBPL1/PSMD6/ADRM1/PSMD9/GTF2B/PPIF/PSMC5/PIK3R1/SLC25A6/PSMD7/ATG2A/PIK3CD 17 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/692 14/8135 0.1103 0.5944 0.5528 ST3GAL3/B4GALT4/CHST4 3 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 13/692 106/8135 0.1142 0.5961 0.5544 NR4A2/JUND/ATF4/MEF2D/ADCY7/CASR/PDE4B/CDKN1A/ARRB2/RAF1/MMP14/HBEGF/NACA 13 KEGG hsa04710 Circadian rhythm 5/692 31/8135 0.1185 0.5961 0.5544 PER1/PRKAB1/CRY2/CSNK1D/CSNK1E 5 KEGG hsa04070 Phosphatidylinositol signaling system 12/692 97/8135 0.1198 0.5961 0.5544 PI4K2A/IP6K1/PIK3CA/MTMR14/MTMR2/PIK3R1/IPPK/IMPAD1/PIP4K2C/PIK3CD/PI4KA/INPP5E 12 KEGG hsa04144 Endocytosis 27/692 251/8135 0.1202 0.5961 0.5544 CHMP1B/VPS37B/CXCR4/VPS28/HLA-G/RAB11FIP4/DNM2/BIN1/HLA-B/TSG101/HLA-C/CLTB/CHMP2B/VPS25/ARF1/ARRB2/SH3GLB1/SNX32/STAM/ACAP1/CBLB/VPS37D/HLA-E/EPN2/LDLRAP1/CHMP4B/IST1 27 KEGG hsa04922 Glucagon signaling pathway 13/692 107/8135 0.1205 0.5961 0.5544 SIK1/PRKAB1/ATF4/CAMK2D/SLC2A1/PPP3R1/CPT1A/PFKFB1/PGAM4/CRTC2/G6PC3/CREBBP/PDHA1 13 KEGG hsa05225 Hepatocellular carcinoma 19/692 168/8135 0.1218 0.5961 0.5544 GADD45A/GSTT1/GSTM4/BAK1/FRAT1/PIK3CA/CCND1/CDK4/FRAT2/GSTP1/NFE2L2/FZD6/CDKN1A/CTNNB1/PIK3R1/RAF1/DVL2/TGFA/PIK3CD 19 KEGG hsa04931 Insulin resistance 13/692 108/8135 0.127 0.6101 0.5675 PRKAB1/PPP1R3B/PIK3CA/NR1H2/SLC2A1/NFKBIA/CPT1A/PIK3R1/PPP1R3D/CRTC2/G6PC3/PIK3CD/PRKCQ 13 KEGG hsa04215 Apoptosis - multiple species 5/692 32/8135 0.1312 0.6101 0.5675 PMAIP1/FADD/BAK1/CASP7/CASP9 5 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 11/692 89/8135 0.1331 0.6101 0.5675 NFKBIE/PIK3CA/MAP3K3/NFKBIA/PPP3R1/NFKBIB/PIK3R1/RAF1/PIK3CD/PRKCQ/LCK 11 KEGG hsa04066 HIF-1 signaling pathway 13/692 109/8135 0.1337 0.6101 0.5675 PIK3CA/CDKN1B/CAMK2D/SLC2A1/CDKN1A/EGLN3/PIK3R1/VHL/PIK3CD/HKDC1/CREBBP/PFKFB3/PDHA1 13 KEGG hsa05416 Viral myocarditis 8/692 60/8135 0.1343 0.6101 0.5675 HLA-G/HLA-DRB1/CCND1/HLA-B/HLA-C/CASP9/HLA-DQA1/HLA-E 8 KEGG hsa04917 Prolactin signaling pathway 9/692 70/8135 0.1378 0.617 0.5739 CISH/IRF1/PIK3CA/CCND1/SOCS4/SOCS2/PIK3R1/RAF1/PIK3CD 9 KEGG hsa05332 Graft-versus-host disease 6/692 42/8135 0.1427 0.6248 0.5811 HLA-G/HLA-DRB1/HLA-B/HLA-C/HLA-DQA1/HLA-E 6 KEGG hsa04140 Autophagy - animal 16/692 141/8135 0.1434 0.6248 0.5811 NRBF2/AKT1S1/TP53INP2/PIK3CA/ATG14/MTMR14/SMCR8/ATG16L2/GABARAPL1/SH3GLB1/PIK3R1/RAF1/CFLAR/ATG2A/PIK3CD/PRKCQ 16 KEGG hsa04932 Non-alcoholic fatty liver disease 17/692 155/8135 0.1665 0.7145 0.6646 UQCRFS1/PRKAB1/ATF4/ADIPOR1/NDUFS1/PIK3CA/NDUFA7/COX8A/CASP7/COX5B/PIK3R1/CYC1/NDUFA11/SDHC/SDHD/PIK3CD/NDUFS3 17 KEGG hsa04670 Leukocyte transendothelial migration 13/692 114/8135 0.1699 0.7145 0.6646 MYL5/CXCR4/RHOH/PIK3CA/EZR/JAM3/ITK/CTNND1/NCF1/CTNNB1/PIK3R1/CLDN7/PIK3CD 13 KEGG hsa04064 NF-kappa B signaling pathway 12/692 104/8135 0.1719 0.7145 0.6646 GADD45A/MAP3K14/TNFAIP3/NFKB2/RELB/BCL10/UBE2I/NFKBIA/CFLAR/PRKCQ/LCK/TRAF3 12 KEGG hsa04218 Cellular senescence 17/692 156/8135 0.173 0.7145 0.6646 GADD45A/CHEK2/LIN54/HLA-G/PIK3CA/CCND1/HLA-B/CDK4/HLA-C/CDKN1A/PPP3R1/MAPKAPK2/PIK3R1/RAF1/SLC25A6/HLA-E/PIK3CD 17 KEGG hsa04110 Cell cycle 14/692 126/8135 0.1826 0.7376 0.686 GADD45A/DBF4/CDKN2D/CHEK2/CDK7/CCND1/CDKN1B/CDK4/ZBTB17/CDKN1A/YWHAG/FZR1/ORC6/CREBBP 14 KEGG hsa05224 Breast cancer 16/692 147/8135 0.1832 0.7376 0.686 GADD45A/BAK1/NFKB2/FRAT1/PIK3CA/CCND1/CDK4/FRAT2/FGF9/FZD6/CDKN1A/CTNNB1/PIK3R1/RAF1/DVL2/PIK3CD 16 KEGG hsa04910 Insulin signaling pathway 15/692 137/8135 0.1868 0.7405 0.6887 PRKAB1/PPP1R3B/FASN/PIK3CA/SOCS4/SOCS2/EXOC7/PIK3R1/RAF1/PPP1R3D/CBLB/FLOT2/G6PC3/PIK3CD/HKDC1 15 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/692 27/8135 0.1931 0.7405 0.6887 FUT6/ST3GAL3/B4GALT4/B3GNT3 4 KEGG hsa04966 Collecting duct acid secretion 4/692 27/8135 0.1931 0.7405 0.6887 ATP6V0C/ATP6V1G1/ATP6V1E1/ATP6V1F 4 KEGG hsa04930 Type II diabetes mellitus 6/692 46/8135 0.1933 0.7405 0.6887 PIK3CA/SOCS4/SOCS2/PIK3R1/PIK3CD/HKDC1 6 KEGG hsa05415 Diabetic cardiomyopathy 21/692 203/8135 0.2019 0.7643 0.711 UQCRFS1/COL1A1/NDUFS1/PIK3CA/NDUFA7/CAMK2D/COX8A/SLC2A1/COX5B/MPC1/NCF1/PPIF/PIK3R1/CYC1/SLC25A6/NDUFA11/SDHC/SDHD/PIK3CD/NDUFS3/PDHA1 21 KEGG hsa00620 Pyruvate metabolism 6/692 47/8135 0.2068 0.7648 0.7114 GLO1/ACYP2/MDH2/DLD/PDHA1/ACYP1 6 KEGG hsa04973 Carbohydrate digestion and absorption 6/692 47/8135 0.2068 0.7648 0.7114 PIK3CA/ATP1A3/PIK3R1/G6PC3/PIK3CD/HKDC1 6 KEGG hsa00650 Butanoate metabolism 4/692 28/8135 0.2112 0.772 0.7181 L2HGDH/EHHADH/BDH2/ACSM5 4 KEGG hsa04152 AMPK signaling pathway 13/692 120/8135 0.2191 0.7916 0.7363 PRKAB1/AKT1S1/FASN/ADIPOR1/PIK3CA/CCND1/CPT1A/PIK3R1/PFKFB1/CRTC2/G6PC3/PIK3CD/PFKFB3 13 KEGG hsa04919 Thyroid hormone signaling pathway 13/692 121/8135 0.2278 0.8012 0.7453 MED4/PIK3CA/NCOA2/CCND1/SLC2A1/ATP1A3/CASP9/CTNNB1/PIK3R1/RAF1/MED13L/PIK3CD/CREBBP 13 KEGG hsa04330 Notch signaling pathway 7/692 59/8135 0.2333 0.8012 0.7453 NCSTN/CIR1/ATXN1L/RFNG/NCOR2/DVL2/CREBBP 7 KEGG hsa04370 VEGF signaling pathway 7/692 59/8135 0.2333 0.8012 0.7453 PIK3CA/PPP3R1/MAPKAPK2/CASP9/PIK3R1/RAF1/PIK3CD 7 KEGG hsa05130 Pathogenic Escherichia coli infection 20/692 197/8135 0.2339 0.8012 0.7453 ABI1/FADD/BAK1/TNFRSF10B/TUBA4A/CASP7/EZR/TUBB2A/TUBA1A/RPS3/ARF1/NCK1/NFKBIA/NFKBIB/CASP9/CLDN7/TUBB6/LPAR2/TUBB1/NAIP 20 KEGG hsa00513 Various types of N-glycan biosynthesis 5/692 39/8135 0.2344 0.8012 0.7453 ALG2/ALG13/ST3GAL3/MAN2A2/TUSC3 5 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 3/692 20/8135 0.2392 0.8012 0.7453 B4GALT7/CSGALNACT2/CHPF 3 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 8/692 70/8135 0.2425 0.8012 0.7453 MAP3K14/ATP6V0C/ATP6V1G1/JAM3/NFKBIA/ATP6V1E1/HBEGF/ATP6V1F 8 KEGG hsa05230 Central carbon metabolism in cancer 8/692 70/8135 0.2425 0.8012 0.7453 PIK3CA/SLC2A1/PIK3R1/RAF1/PGAM4/PIK3CD/HKDC1/PDHA1 8 KEGG hsa05165 Human papillomavirus infection 32/692 331/8135 0.2462 0.8012 0.7453 IRF1/PTGER4/COL1A1/FADD/BAK1/RFNG/ATP6V0C/HLA-G/PIK3CA/CCND1/HLA-B/ATP6V1G1/TBPL1/ITGA10/CDKN1B/CDK4/HLA-C/FZD6/CDKN1A/COL6A2/THBS1/CTNNB1/PIK3R1/RAF1/ATP6V1E1/NFX1/HLA-E/DVL2/ATP6V1F/PIK3CD/CREBBP/TRAF3 32 KEGG hsa00190 Oxidative phosphorylation 14/692 134/8135 0.2482 0.8012 0.7453 UQCRFS1/NDUFS1/ATP6V0C/ATP6V1G1/NDUFA7/COX8A/COX5B/CYC1/ATP6V1E1/NDUFA11/SDHC/ATP6V1F/SDHD/NDUFS3 14 KEGG hsa05144 Malaria 6/692 50/8135 0.2494 0.8012 0.7453 HBA2/HBB/CR1/THBS1/IL12A/GYPB 6 KEGG hsa04658 Th1 and Th2 cell differentiation 10/692 92/8135 0.2546 0.8096 0.7531 NFKBIE/HLA-DRB1/NFKBIA/PPP3R1/NFKBIB/IL12A/IL13/HLA-DQA1/PRKCQ/LCK 10 KEGG hsa05160 Hepatitis C 16/692 157/8135 0.26 0.8131 0.7563 FADD/BAK1/PIK3CA/CCND1/CDK4/CDKN1A/NFKBIA/YWHAG/CASP9/CTNNB1/PIK3R1/RAF1/CLDN7/CFLAR/PIK3CD/TRAF3 16 KEGG hsa04662 B cell receptor signaling pathway 9/692 82/8135 0.2608 0.8131 0.7563 NFKBIE/PIK3CA/BCL10/NFKBIA/PPP3R1/NFKBIB/PIK3R1/RAF1/PIK3CD 9 KEGG hsa04216 Ferroptosis 5/692 41/8135 0.2674 0.8198 0.7625 SLC3A2/FTL/FTH1/ACSL3/PRNP 5 KEGG hsa00052 Galactose metabolism 4/692 31/8135 0.2681 0.8198 0.7625 AKR1B1/G6PC3/HKDC1/GLA 4 KEGG hsa01200 Carbon metabolism 12/692 115/8135 0.2715 0.8218 0.7644 PSPH/DLST/SDSL/PGAM4/PRPS1L1/SDHC/SDHD/PGP/MDH2/HKDC1/DLD/PDHA1 12 KEGG hsa04657 IL-17 signaling pathway 10/692 94/8135 0.2763 0.8218 0.7644 JUND/TRAF4/FOSB/FADD/TNFAIP3/NFKBIA/MAPK6/IL13/S100A9/TRAF3 10 KEGG hsa05163 Human cytomegalovirus infection 22/692 225/8135 0.2765 0.8218 0.7644 PTGER4/ATF4/CXCR4/FADD/BAK1/ADCY7/HLA-G/PIK3CA/CCND1/HLA-B/CDK4/HLA-C/CDKN1A/NFKBIA/PPP3R1/GNG4/CASP9/CTNNB1/PIK3R1/RAF1/HLA-E/PIK3CD 22 KEGG hsa05226 Gastric cancer 15/692 149/8135 0.2847 0.8354 0.7771 GADD45A/BAK1/FRAT1/PIK3CA/CCND1/CDKN1B/FRAT2/FGF9/FZD6/CDKN1A/CTNNB1/PIK3R1/RAF1/DVL2/PIK3CD 15 KEGG hsa05217 Basal cell carcinoma 7/692 63/8135 0.2869 0.8354 0.7771 GADD45A/BAK1/FZD6/CDKN1A/CTNNB1/DVL2/SUFU 7 KEGG hsa04010 MAPK signaling pathway 28/692 294/8135 0.2912 0.8354 0.7771 GADD45A/MAP3K14/AREG/MAPK8IP1/JUND/PPM1B/ATF4/DUSP8/NFKB2/DUSP1/RELB/MAPK8IP2/DUSP10/PPM1A/LAMTOR3/FGF9/DUSP2/MAP3K3/NR4A1/ARRB2/PPP3R1/NF1/MAPKAPK2/MAP2K7/RAF1/TGFA/RPS6KA5/RAPGEF2 28 KEGG hsa05418 Fluid shear stress and atherosclerosis 14/692 139/8135 0.2932 0.8354 0.7771 GSTT1/KLF2/GSTM4/DUSP1/PIK3CA/SUMO3/GSTP1/NFE2L2/NCF1/CTNNB1/PIK3R1/MAP2K7/PIK3CD/SUMO4 14 KEGG hsa05320 Autoimmune thyroid disease 6/692 53/8135 0.2942 0.8354 0.7771 HLA-G/HLA-DRB1/HLA-B/HLA-C/HLA-DQA1/HLA-E 6 KEGG hsa03450 Non-homologous end-joining 2/692 13/8135 0.3047 0.852 0.7925 FEN1/XRCC4 2 KEGG hsa00051 Fructose and mannose metabolism 4/692 33/8135 0.3074 0.852 0.7925 AKR1B1/PFKFB1/HKDC1/PFKFB3 4 KEGG hsa03015 mRNA surveillance pathway 10/692 97/8135 0.3099 0.852 0.7925 CLP1/SAP18/DDX19B/UPF1/PELO/CPSF1/DAZAP1/PABPC3/GSPT2/GLE1 10 KEGG hsa00515 Mannose type O-glycan biosynthesis 3/692 23/8135 0.3108 0.852 0.7925 ST3GAL3/CHST10/FKTN 3 KEGG hsa01522 Endocrine resistance 10/692 98/8135 0.3213 0.8591 0.7991 ADCY7/PIK3CA/CCND1/CDKN1B/CDK4/CDKN1A/PIK3R1/RAF1/HBEGF/PIK3CD 10 KEGG hsa04936 Alcoholic liver disease 14/692 142/8135 0.3213 0.8591 0.7991 MAP3K14/PRKAB1/FASN/ADIPOR1/FADD/CCND1/NFKBIA/CPT1A/CTNNB1/MAP2K7/IL12A/TRA2B/C5/TRAF3 14 KEGG hsa04650 Natural killer cell mediated cytotoxicity 13/692 131/8135 0.3218 0.8591 0.7991 MICA/MICB/HLA-G/PIK3CA/HLA-B/TNFRSF10B/HLA-C/PPP3R1/PIK3R1/RAF1/HLA-E/PIK3CD/LCK 13 KEGG hsa00040 Pentose and glucuronate interconversions 4/692 34/8135 0.3273 0.8591 0.7991 AKR1B1/CRYL1/XYLB/UGDH 4 KEGG hsa04714 Thermogenesis 22/692 232/8135 0.3275 0.8591 0.7991 UQCRFS1/PRKAB1/AKT1S1/NDUFS1/ADCY7/NDUFA7/COX8A/PNPLA2/COX5B/COX19/CPT1A/SLC25A20/CYC1/NDUFA11/FRS2/NDUFAF4/SDHC/ACSL3/SDHD/NDUFS3/NDUFAF6/BMP8B 22 KEGG hsa05140 Leishmaniasis 8/692 77/8135 0.3311 0.8591 0.7991 EEF1A2/HLA-DRB1/NFKBIA/NFKBIB/CR1/NCF1/IL12A/HLA-DQA1 8 KEGG hsa04540 Gap junction 9/692 88/8135 0.3323 0.8591 0.7991 ADCY7/TUBA4A/TUBB2A/CSNK1D/TUBA1A/DRD1/RAF1/TUBB6/TUBB1 9 KEGG hsa04340 Hedgehog signaling pathway 6/692 56/8135 0.3404 0.8618 0.8017 GAS1/CCND1/CSNK1D/ARRB2/CSNK1E/SUFU 6 KEGG hsa04923 Regulation of lipolysis in adipocytes 6/692 56/8135 0.3404 0.8618 0.8017 ADCY7/PIK3CA/PTGS1/PNPLA2/PIK3R1/PIK3CD 6 KEGG hsa05221 Acute myeloid leukemia 7/692 67/8135 0.343 0.8618 0.8017 PIM1/PIK3CA/CCND1/PIM2/PIK3R1/RAF1/PIK3CD 7 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 8/692 78/8135 0.3442 0.8618 0.8017 GSTT1/GSTM4/GSTP1/CYP2B6/AKR7A2/HSD11B1/AKR7A3/AKR1C1 8 KEGG hsa04664 Fc epsilon RI signaling pathway 7/692 68/8135 0.3572 0.8875 0.8255 PIK3CA/PIK3R1/MAP2K7/RAF1/IL13/ALOX5/PIK3CD 7 KEGG hsa03030 DNA replication 4/692 36/8135 0.3672 0.9026 0.8395 RNASEH1/FEN1/POLE3/RFC2 4 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/692 15/8135 0.369 0.9026 0.8395 ST3GAL5/B3GALT4 2 KEGG hsa01250 Biosynthesis of nucleotide sugars 4/692 37/8135 0.3871 0.9327 0.8675 GNE/UGDH/GNPNAT1/HKDC1 4 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 4/692 37/8135 0.3871 0.9327 0.8675 PIK3CA/ATP1A3/PIK3R1/PIK3CD 4 KEGG hsa04912 GnRH signaling pathway 9/692 93/8135 0.3942 0.9426 0.8768 ATF4/GNRH1/ADCY7/CAMK2D/MAP3K3/MAP2K7/RAF1/MMP14/HBEGF 9 KEGG hsa00430 Taurine and hypotaurine metabolism 2/692 16/8135 0.4003 0.9479 0.8817 ADO/GGT1 2 KEGG hsa04978 Mineral absorption 6/692 60/8135 0.403 0.9479 0.8817 FTL/SLC30A1/MT2A/FTH1/ATP7A/ATP1A3 6 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 5/692 49/8135 0.4054 0.9479 0.8817 GNE/NPL/UGDH/GNPNAT1/HKDC1 5 KEGG hsa05110 Vibrio cholerae infection 5/692 50/8135 0.4227 0.9812 0.9127 ATP6V0C/ATP6V1G1/ARF1/ATP6V1E1/ATP6V1F 5 KEGG hsa04213 Longevity regulating pathway - multiple species 6/692 62/8135 0.4342 1 0.9302 PRKAB1/AKT1S1/ADCY7/PIK3CA/PIK3R1/PIK3CD 6 KEGG hsa01232 Nucleotide metabolism 8/692 85/8135 0.4372 1 0.9302 CANT1/AMPD2/ASMTL/HPRT1/NT5M/AK1/AK3/ENTPD1 8 KEGG hsa00061 Fatty acid biosynthesis 2/692 18/8135 0.4605 1 0.9302 FASN/ACSL3 2 KEGG hsa04929 GnRH secretion 6/692 64/8135 0.4651 1 0.9302 GNRH1/PIK3CA/ARRB2/PIK3R1/RAF1/PIK3CD 6 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 3/692 30/8135 0.4759 1 0.9302 PGP/MDH2/DLD 3 KEGG hsa03010 Ribosome 14/692 158/8135 0.4777 1 0.9302 MRPS18A/RPS26/RPL36AL/MRPL32/RPS3/RPS19/MRPL11/MRPL10/MRPL27/RPL12/RPL37/MRPS2/RPS15/RPSA 14 KEGG hsa00380 Tryptophan metabolism 4/692 42/8135 0.4847 1 0.9302 DLST/EHHADH/ALDH8A1/DLD 4 KEGG hsa04217 Necroptosis 14/692 159/8135 0.4875 1 0.9302 SPATA2/CHMP1B/FADD/FTL/TNFAIP3/FAF1/TNFRSF10B/FTH1/CAMK2D/CHMP2B/SHARPIN/SLC25A6/CFLAR/CHMP4B 14 KEGG hsa04211 Longevity regulating pathway 8/692 89/8135 0.4898 1 0.9302 PRKAB1/AKT1S1/ATF4/ADIPOR1/ADCY7/PIK3CA/PIK3R1/PIK3CD 8 KEGG hsa04141 Protein processing in endoplasmic reticulum 15/692 171/8135 0.4903 1 0.9302 PPP1R15A/ATF4/UBXN6/DNAJB1/FBXO2/SAR1A/BAK1/UBE2J1/NFE2L2/DERL2/SSR4/MAP2K7/HERPUD1/NPLOC4/TUSC3 15 KEGG hsa03460 Fanconi anemia pathway 5/692 54/8135 0.4908 1 0.9302 WDR48/TELO2/RMI2/FANCE/TOP3B 5 KEGG hsa05310 Asthma 3/692 31/8135 0.4981 1 0.9302 HLA-DRB1/IL13/HLA-DQA1 3 KEGG hsa04721 Synaptic vesicle cycle 7/692 78/8135 0.4994 1 0.9302 ATP6V0C/DNM2/ATP6V1G1/CLTB/ATP6V1E1/ATP6V1F/NAPA 7 KEGG hsa00071 Fatty acid degradation 4/692 43/8135 0.5035 1 0.9302 CPT1A/ACAA1/EHHADH/ACSL3 4 KEGG hsa05161 Hepatitis B 14/692 162/8135 0.5166 1 0.9302 ATF4/FADD/EGR2/PIK3CA/CDKN1A/NFKBIA/CASP10/CASP9/PIK3R1/MAP2K7/RAF1/PIK3CD/CREBBP/TRAF3 14 KEGG hsa00100 Steroid biosynthesis 2/692 20/8135 0.5171 1 0.9302 DHCR7/CYP2R1 2 KEGG hsa04974 Protein digestion and absorption 9/692 103/8135 0.5177 1 0.9302 SLC3A2/COL1A1/CTRL/COL27A1/ATP1A3/COL6A2/SLC3A1/SLC7A9/COL11A1 9 KEGG hsa04620 Toll-like receptor signaling pathway 9/692 104/8135 0.5297 1 0.9302 FADD/PIK3CA/NFKBIA/PIK3R1/MAP2K7/IL12A/PIK3CD/TLR1/TRAF3 9 KEGG hsa01212 Fatty acid metabolism 5/692 57/8135 0.5399 1 0.9302 FASN/CPT1A/ACAA1/EHHADH/ACSL3 5 KEGG hsa03410 Base excision repair 3/692 33/8135 0.5412 1 0.9302 FEN1/NEIL2/POLE3 3 KEGG hsa04926 Relaxin signaling pathway 11/692 129/8135 0.543 1 0.9302 COL1A1/ATF4/ADCY7/PIK3CA/ARRB2/NFKBIA/GNG4/PIK3R1/MAP2K7/RAF1/PIK3CD 11 KEGG hsa04622 RIG-I-like receptor signaling pathway 6/692 70/8135 0.5545 1 0.9302 FADD/NFKBIA/NFKBIB/CASP10/IL12A/TRAF3 6 KEGG hsa00480 Glutathione metabolism 5/692 58/8135 0.5558 1 0.9302 GSTT1/GSTM4/ODC1/GSTP1/GGT1 5 KEGG hsa04310 Wnt signaling pathway 14/692 167/8135 0.5641 1 0.9302 FRAT1/CCND1/CAMK2D/FRAT2/CTNNBIP1/FZD6/CSNK1E/PPP3R1/BAMBI/CTNNB1/ROR2/SENP2/DVL2/CREBBP 14 KEGG hsa00900 Terpenoid backbone biosynthesis 2/692 22/8135 0.5696 1 0.9302 RCE1/IDI1 2 KEGG hsa05152 Tuberculosis 15/692 180/8135 0.5732 1 0.9302 FADD/ATP6V0C/HLA-DRB1/CEBPG/CAMK2D/BCL10/PPP3R1/CR1/CASP10/CASP9/RAF1/IL12A/HLA-DQA1/TLR1/CREBBP 15 KEGG hsa04659 Th17 cell differentiation 9/692 108/8135 0.5766 1 0.9302 NFKBIE/IL21R/HLA-DRB1/NFKBIA/PPP3R1/NFKBIB/HLA-DQA1/PRKCQ/LCK 9 KEGG hsa00920 Sulfur metabolism 1/692 10/8135 0.5892 1 0.9302 IMPAD1 1 KEGG hsa04666 Fc gamma R-mediated phagocytosis 8/692 97/8135 0.5901 1 0.9302 PIK3CA/DNM2/BIN1/CFL2/NCF1/PIK3R1/RAF1/PIK3CD 8 KEGG hsa00280 Valine, leucine and isoleucine degradation 4/692 48/8135 0.5924 1 0.9302 HSD17B10/ACAA1/EHHADH/DLD 4 KEGG hsa00500 Starch and sucrose metabolism 3/692 36/8135 0.6015 1 0.9302 GBE1/G6PC3/HKDC1 3 KEGG hsa00590 Arachidonic acid metabolism 5/692 61/8135 0.6017 1 0.9302 PTGS1/CYP2B6/ALOX5/GGT1/PLA2G2A 5 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 8/692 98/8135 0.6019 1 0.9302 PTGER4/ADCY7/PIK3CA/CAMK2D/PIK3R1/PIK3CD/PRKCH/PRKCQ 8 KEGG hsa04672 Intestinal immune network for IgA production 4/692 49/8135 0.6091 1 0.9302 MAP3K14/CXCR4/HLA-DRB1/HLA-DQA1 4 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2/692 24/8135 0.6178 1 0.9302 B4GALT7/NDST1 2 KEGG hsa04977 Vitamin digestion and absorption 2/692 24/8135 0.6178 1 0.9302 SLC19A2/TCN2 2 KEGG hsa04611 Platelet activation 10/692 124/8135 0.618 1 0.9302 COL1A1/ADCY7/PIK3CA/MYLK4/PTGS1/PTGIR/P2RY12/PIK3R1/PIK3CD/STIM1 10 KEGG hsa05143 African trypanosomiasis 3/692 37/8135 0.6204 1 0.9302 HBA2/HBB/IL12A 3 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 8/692 100/8135 0.6251 1 0.9302 PIM1/COL1A1/PIK3CA/CCND1/CDKN1B/CDK4/PIK3R1/PIK3CD 8 KEGG hsa00510 N-Glycan biosynthesis 4/692 50/8135 0.6253 1 0.9302 ALG2/ALG13/MAN2A2/TUSC3 4 KEGG hsa04979 Cholesterol metabolism 4/692 50/8135 0.6253 1 0.9302 VAPA/LRPAP1/NCEH1/LDLRAP1 4 KEGG hsa05170 Human immunodeficiency virus 1 infection 17/692 212/8135 0.6383 1 0.9302 CXCR4/FADD/BAK1/HLA-G/PIK3CA/HLA-B/CFL2/HLA-C/NFKBIA/PPP3R1/GNG4/CASP9/PIK3R1/MAP2K7/RAF1/HLA-E/PIK3CD 17 KEGG hsa00592 alpha-Linolenic acid metabolism 2/692 25/8135 0.6403 1 0.9302 ACAA1/PLA2G2A 2 KEGG hsa00270 Cysteine and methionine metabolism 4/692 51/8135 0.641 1 0.9302 CTH/SDSL/AMD1/MDH2 4 KEGG hsa04914 Progesterone-mediated oocyte maturation 8/692 102/8135 0.6476 1 0.9302 ADCY7/PIK3CA/AURKA/PIK3R1/RAF1/FZR1/KIF22/PIK3CD 8 KEGG hsa05100 Bacterial invasion of epithelial cells 6/692 77/8135 0.6492 1 0.9302 PIK3CA/DNM2/CLTB/CTNNB1/PIK3R1/PIK3CD 6 KEGG hsa00600 Sphingolipid metabolism 4/692 52/8135 0.6564 1 0.9302 DEGS1/SPTLC3/SMPD4/GLA 4 KEGG hsa00230 Purine metabolism 10/692 128/8135 0.6582 1 0.9302 CANT1/ADCY7/AMPD2/PDE4B/HPRT1/NT5M/AK1/PRPS1L1/AK3/ENTPD1 10 KEGG hsa05321 Inflammatory bowel disease 5/692 65/8135 0.6585 1 0.9302 IL21R/HLA-DRB1/IL12A/IL13/HLA-DQA1 5 KEGG hsa04612 Antigen processing and presentation 6/692 78/8135 0.6616 1 0.9302 HLA-G/HLA-DRB1/HLA-B/HLA-C/HLA-DQA1/HLA-E 6 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 6/692 79/8135 0.6738 1 0.9302 PIK3CA/NF1/PIK3R1/RAF1/TGFA/PIK3CD 6 KEGG hsa04934 Cushing syndrome 12/692 155/8135 0.677 1 0.9302 ATF4/ADCY7/CCND1/CDKN1B/CDK4/CAMK2D/FZD6/NR4A1/CDKN1A/NCEH1/CTNNB1/DVL2 12 KEGG hsa05205 Proteoglycans in cancer 16/692 205/8135 0.6792 1 0.9302 NUDT16L1/COL1A1/PIK3CA/CCND1/CAMK2D/TWIST1/EZR/FZD6/CDKN1A/THBS1/CTNNB1/PIK3R1/RAF1/FRS2/HBEGF/PIK3CD 16 KEGG hsa00062 Fatty acid elongation 2/692 27/8135 0.6821 1 0.9302 ACOT2/THEM5 2 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 2/692 27/8135 0.6821 1 0.9302 ACOT2/ACAA1 2 KEGG hsa00010 Glycolysis / Gluconeogenesis 5/692 67/8135 0.6849 1 0.9302 PGAM4/G6PC3/HKDC1/DLD/PDHA1 5 KEGG hsa04720 Long-term potentiation 5/692 67/8135 0.6849 1 0.9302 ATF4/CAMK2D/PPP3R1/RAF1/CREBBP 5 KEGG hsa04935 Growth hormone synthesis, secretion and action 9/692 119/8135 0.6929 1 0.9302 JUNB/ATF4/ADCY7/PIK3CA/SOCS2/PIK3R1/RAF1/PIK3CD/CREBBP 9 KEGG hsa04360 Axon guidance 14/692 182/8135 0.6937 1 0.9302 MYL5/CXCR4/SEMA4C/PIK3CA/CFL2/CAMK2D/NCK1/LRIG2/PPP3R1/SEMA4F/PIK3R1/RAF1/EPHA4/PIK3CD 14 KEGG hsa05171 Coronavirus disease - COVID-19 18/692 232/8135 0.6953 1 0.9302 CFD/PIK3CA/RPS26/RPL36AL/RPS3/NFKBIA/RPS19/NFKBIB/PIK3R1/RPL12/IL12A/HBEGF/RPL37/PIK3CD/RPS15/C5/TRAF3/RPSA 18 KEGG hsa04142 Lysosome 10/692 132/8135 0.696 1 0.9302 ATP6V0C/CTSW/PLA2G15/CLTB/NAGPA/LAPTM4A/HYAL3/SCARB2/SUMF1/GLA 10 KEGG hsa04350 TGF-beta signaling pathway 7/692 94/8135 0.6984 1 0.9302 TGIF2/BAMBI/THBS1/TGIF1/INHBC/CREBBP/BMP8B 7 KEGG hsa05031 Amphetamine addiction 5/692 69/8135 0.7098 1 0.9302 ATF4/FOSB/CAMK2D/PPP3R1/DRD1 5 KEGG hsa04962 Vasopressin-regulated water reabsorption 3/692 44/8135 0.7353 1 0.9302 DCTN4/DCTN5/DCTN6 3 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/692 15/8135 0.7368 1 0.9302 GLA 1 KEGG hsa00730 Thiamine metabolism 1/692 15/8135 0.7368 1 0.9302 AK1 1 KEGG hsa00240 Pyrimidine metabolism 4/692 58/8135 0.7389 1 0.9302 CANT1/ASMTL/NT5M/ENTPD1 4 KEGG hsa04610 Complement and coagulation cascades 6/692 85/8135 0.741 1 0.9302 CD46/CFD/CR1/PROS1/C5/KLKB1 6 KEGG hsa05145 Toxoplasmosis 8/692 112/8135 0.7475 1 0.9302 HLA-DRB1/NFKBIA/NFKBIB/PPIF/CASP9/IL12A/HLA-DQA1/ALOX5 8 KEGG hsa04915 Estrogen signaling pathway 10/692 138/8135 0.7476 1 0.9302 ATF4/ADCY7/PIK3CA/NCOA2/PIK3R1/RAF1/HBEGF/TGFA/PIK3CD/KRT19 10 KEGG hsa05417 Lipid and atherosclerosis 16/692 215/8135 0.7498 1 0.9302 ATF4/PIK3CA/TNFRSF10B/CAMK2D/CASP7/NFE2L2/CYP2B6/NFKBIA/PPP3R1/NCF1/CASP9/PIK3R1/MAP2K7/IL12A/PIK3CD/TRAF3 16 KEGG hsa04911 Insulin secretion 6/692 86/8135 0.7511 1 0.9302 ATF4/ADCY7/CAMK2D/SLC2A1/ATP1A3/GPR119 6 KEGG hsa04151 PI3K-Akt signaling pathway 27/692 354/8135 0.7553 1 0.9302 AREG/PHLPP1/COL1A1/ATF4/PIK3CA/CCND1/ITGA10/CDKN1B/OSM/CDK4/FGF9/EPOR/NR4A1/CDKN1A/GNG4/YWHAG/COL6A2/THBS1/CASP9/PIK3R1/RAF1/LPAR2/TGFA/CRTC2/G6PC3/PIK3CD/MTCP1 27 KEGG hsa04371 Apelin signaling pathway 10/692 139/8135 0.7556 1 0.9302 PRKAB1/NRF1/MEF2D/KLF2/ADCY7/CCND1/MYLK4/GNG4/RAF1/HDAC4 10 KEGG hsa04725 Cholinergic synapse 8/692 113/8135 0.7563 1 0.9302 ATF4/ADCY7/PIK3CA/CAMK2D/GNG4/PIK3R1/CHRM4/PIK3CD 8 KEGG hsa04916 Melanogenesis 7/692 101/8135 0.767 1 0.9302 ADCY7/CAMK2D/FZD6/CTNNB1/RAF1/DVL2/CREBBP 7 KEGG hsa00640 Propanoate metabolism 2/692 32/8135 0.7695 1 0.9302 EHHADH/DLD 2 KEGG hsa04136 Autophagy - other 2/692 32/8135 0.7695 1 0.9302 GABARAPL1/ATG2A 2 KEGG hsa00561 Glycerolipid metabolism 4/692 61/8135 0.7741 1 0.9302 LCLAT1/PNPLA2/AKR1B1/GLA 4 KEGG hsa03420 Nucleotide excision repair 3/692 47/8135 0.7754 1 0.9302 CDK7/POLE3/RFC2 3 KEGG hsa05142 Chagas disease 7/692 102/8135 0.7758 1 0.9302 FADD/PIK3CA/NFKBIA/PIK3R1/CFLAR/IL12A/PIK3CD 7 KEGG hsa01230 Biosynthesis of amino acids 5/692 75/8135 0.7762 1 0.9302 PSPH/CTH/SDSL/PGAM4/PRPS1L1 5 KEGG hsa03320 PPAR signaling pathway 5/692 75/8135 0.7762 1 0.9302 ACOX2/CPT1A/ACAA1/EHHADH/ACSL3 5 KEGG hsa04120 Ubiquitin mediated proteolysis 10/692 142/8135 0.7785 1 0.9302 FBXO2/UBE2J1/UBE2S/UBE2I/UBE2B/CDC34/CBLB/FZR1/VHL/CUL7 10 KEGG hsa00120 Primary bile acid biosynthesis 1/692 17/8135 0.7797 1 0.9302 ACOX2 1 KEGG hsa00450 Selenocompound metabolism 1/692 17/8135 0.7797 1 0.9302 CTH 1 KEGG hsa04976 Bile secretion 6/692 89/8135 0.7799 1 0.9302 ADCY7/SLC2A1/NCEH1/ATP1A3/SLC22A7/SLC4A5 6 KEGG hsa04971 Gastric acid secretion 5/692 76/8135 0.786 1 0.9302 ADCY7/MYLK4/CAMK2D/EZR/ATP1A3 5 KEGG hsa05133 Pertussis 5/692 76/8135 0.786 1 0.9302 IRF1/CFL2/CASP7/IL12A/C5 5 KEGG hsa00310 Lysine degradation 4/692 63/8135 0.7955 1 0.9302 DLST/EHHADH/SETD1A/DLD 4 KEGG hsa04623 Cytosolic DNA-sensing pathway 4/692 63/8135 0.7955 1 0.9302 NFKBIA/NFKBIB/POLR3C/POLR2F 4 KEGG hsa00565 Ether lipid metabolism 3/692 49/8135 0.7992 1 0.9302 GDPD3/CHPT1/PLA2G2A 3 KEGG hsa05030 Cocaine addiction 3/692 49/8135 0.7992 1 0.9302 ATF4/FOSB/DRD1 3 KEGG hsa05207 Chemical carcinogenesis - receptor activation 15/692 212/8135 0.8092 1 0.9302 GSTT1/ATF4/GSTM4/BCL6/ADCY7/PIK3CA/CCND1/FGF9/CYP2B6/ARRB2/KPNA5/PIK3R1/RAF1/PIK3CD/KPNA2 15 KEGG hsa05323 Rheumatoid arthritis 6/692 93/8135 0.8142 1 0.9302 ATP6V0C/HLA-DRB1/ATP6V1G1/ATP6V1E1/HLA-DQA1/ATP6V1F 6 KEGG hsa04927 Cortisol synthesis and secretion 4/692 65/8135 0.8151 1 0.9302 ATF4/ADCY7/NR4A1/NCEH1 4 KEGG hsa04270 Vascular smooth muscle contraction 9/692 134/8135 0.8156 1 0.9302 ADCY7/MYLK4/RAMP3/PTGIR/RAF1/EDN2/PLA2G2A/PRKCH/PRKCQ 9 KEGG hsa00531 Glycosaminoglycan degradation 1/692 19/8135 0.8157 1 0.9302 HYAL3 1 KEGG hsa04913 Ovarian steroidogenesis 3/692 51/8135 0.8209 1 0.9302 ACOT2/ADCY7/ALOX5 3 KEGG hsa00983 Drug metabolism - other enzymes 5/692 80/8135 0.822 1 0.9302 GSTT1/GSTM4/GSTP1/CES2/HPRT1 5 KEGG hsa00760 Nicotinate and nicotinamide metabolism 2/692 36/8135 0.8235 1 0.9302 NT5M/QPRT 2 KEGG hsa04810 Regulation of actin cytoskeleton 15/692 218/8135 0.8405 1 0.9302 MYL5/CXCR4/PIK3CA/ITGA10/MYLK4/CFL2/FGD1/EZR/FGF9/PIK3R1/RAF1/LPAR2/CHRM4/PIP4K2C/PIK3CD 15 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 3/692 53/8135 0.8405 1 0.9302 DNM2/CLTB/ATP1A3 3 KEGG hsa04062 Chemokine signaling pathway 13/692 192/8135 0.8426 1 0.9302 CXCR4/ADCY7/PIK3CA/ITK/ARRB2/NFKBIA/NFKBIB/NCF1/GNG4/PPBP/PIK3R1/RAF1/PIK3CD 13 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 4/692 69/8135 0.8498 1 0.9302 GSTT1/GSTM4/GSTP1/HSD11B1 4 KEGG hsa00564 Glycerophospholipid metabolism 6/692 98/8135 0.851 1 0.9302 LCLAT1/PLA2G15/CHPT1/PEMT/PLA2G2A/ETNK2 6 KEGG hsa04925 Aldosterone synthesis and secretion 6/692 98/8135 0.851 1 0.9302 NR4A2/ATF4/ADCY7/CAMK2D/NR4A1/ATP1A3 6 KEGG hsa04024 cAMP signaling pathway 15/692 221/8135 0.8546 1 0.9302 ADCY7/HTR6/PIK3CA/CAMK2D/PDE4B/NFKBIA/DRD1/ATP1A3/PIK3R1/RAF1/GPR119/CNGA1/EDN2/PIK3CD/CREBBP 15 KEGG hsa00340 Histidine metabolism 1/692 22/8135 0.8589 1 0.9302 AMDHD1 1 KEGG hsa04530 Tight junction 11/692 169/8135 0.862 1 0.9302 PRKAB1/CCND1/WHAMM/CDK4/TUBA4A/EZR/JAM3/TUBA1A/MAP2K7/CLDN7/RAPGEF2 11 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 6/692 100/8135 0.864 1 0.9302 CXCR4/TNFRSF10B/TNFRSF14/PPBP/IL20/IL34 6 KEGG hsa04520 Adherens junction 4/692 71/8135 0.865 1 0.9302 YES1/CTNND1/CTNNB1/CREBBP 4 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 9/692 143/8135 0.869 1 0.9302 PIK3CA/HOXA1/FZD6/CTNNB1/PIK3R1/RAF1/DVL2/INHBC/PIK3CD 9 KEGG hsa03060 Protein export 1/692 23/8135 0.871 1 0.9302 SRP68 1 KEGG hsa03430 Mismatch repair 1/692 23/8135 0.871 1 0.9302 RFC2 1 KEGG hsa04964 Proximal tubule bicarbonate reclamation 1/692 23/8135 0.871 1 0.9302 ATP1A3 1 KEGG hsa00982 Drug metabolism - cytochrome P450 4/692 72/8135 0.8721 1 0.9302 GSTT1/GSTM4/GSTP1/CYP2B6 4 KEGG hsa04260 Cardiac muscle contraction 5/692 87/8135 0.8732 1 0.9302 UQCRFS1/COX8A/COX5B/ATP1A3/CYC1 5 KEGG hsa03440 Homologous recombination 2/692 41/8135 0.8749 1 0.9302 RAD54B/TOP3B 2 KEGG hsa05146 Amoebiasis 6/692 102/8135 0.876 1 0.9302 COL1A1/PIK3CA/PIK3R1/IL12A/PIK3CD/SERPINB6 6 KEGG hsa04071 Sphingolipid signaling pathway 7/692 119/8135 0.8899 1 0.9302 PIK3CA/S1PR5/DEGS1/SPTLC3/PIK3R1/RAF1/PIK3CD 7 KEGG hsa05032 Morphine addiction 5/692 91/8135 0.8964 1 0.9302 ADCY7/PDE4B/ARRB2/DRD1/GNG4 5 KEGG hsa04514 Cell adhesion molecules 9/692 149/8135 0.8971 1 0.9302 HLA-G/HLA-DRB1/HLA-B/HLA-C/ICAM3/JAM3/CLDN7/HLA-DQA1/HLA-E 9 KEGG hsa00790 Folate biosynthesis 1/692 26/8135 0.9013 1 0.9302 AKR1B1 1 KEGG hsa04022 cGMP-PKG signaling pathway 10/692 167/8135 0.9122 1 0.9302 ATF4/MEF2D/ADCY7/MYLK4/PPP3R1/ATP1A3/PPIF/RAF1/SLC25A6/CNGA1 10 KEGG hsa00514 Other types of O-glycan biosynthesis 2/692 47/8135 0.9183 1 0.9302 RFNG/ST3GAL3 2 KEGG hsa05150 Staphylococcus aureus infection 5/692 96/8135 0.9202 1 0.9302 CFD/HLA-DRB1/HLA-DQA1/KRT19/C5 5 KEGG hsa04713 Circadian entrainment 5/692 97/8135 0.9243 1 0.9302 PER1/ADCY7/CAMK2D/GNG4/RPS6KA5 5 KEGG hsa00591 Linoleic acid metabolism 1/692 29/8135 0.9244 1 0.9302 PLA2G2A 1 KEGG hsa04392 Hippo signaling pathway - multiple species 1/692 29/8135 0.9244 1 0.9302 CSNK1E 1 KEGG hsa04744 Phototransduction 1/692 29/8135 0.9244 1 0.9302 CNGA1 1 KEGG hsa04390 Hippo signaling pathway 9/692 157/8135 0.9265 1 0.9302 AREG/CCND1/CSNK1D/FZD6/CSNK1E/YWHAG/CTNNB1/DVL2/BMP8B 9 KEGG hsa05231 Choline metabolism in cancer 5/692 98/8135 0.9282 1 0.9302 PIK3CA/CHPT1/PIK3R1/RAF1/PIK3CD 5 KEGG hsa04510 Focal adhesion 12/692 201/8135 0.9302 1 0.9302 MYL5/COL1A1/PIK3CA/CCND1/ITGA10/MYLK4/COL6A2/THBS1/CTNNB1/PIK3R1/RAF1/PIK3CD 12 KEGG hsa00030 Pentose phosphate pathway 1/692 30/8135 0.9309 1 0.9302 PRPS1L1 1 KEGG hsa00053 Ascorbate and aldarate metabolism 1/692 30/8135 0.9309 1 0.9302 UGDH 1 KEGG hsa04726 Serotonergic synapse 6/692 115/8135 0.9342 1 0.9302 DUSP1/HTR6/PTGS1/GNG4/RAF1/ALOX5 6 KEGG hsa00830 Retinol metabolism 3/692 68/8135 0.9368 1 0.9302 DHRS4/CYP2B6/DHRS4L2 3 KEGG hsa00410 beta-Alanine metabolism 1/692 31/8135 0.9368 1 0.9302 EHHADH 1 KEGG hsa00330 Arginine and proline metabolism 2/692 51/8135 0.9389 1 0.9302 ODC1/AMD1 2 KEGG hsa05131 Shigellosis 15/692 247/8135 0.94 1 0.9302 AKT1S1/MYL5/PIK3CA/ATG14/BCL10/ARF1/NFKBIA/SHARPIN/NFKBIB/PIK3R1/PIK3CD/RPS6KA5/HKDC1/PRKCQ/NAIP 15 KEGG hsa04924 Renin secretion 3/692 69/8135 0.9407 1 0.9302 PTGER4/PPP3R1/EDN2 3 KEGG hsa04072 Phospholipase D signaling pathway 8/692 148/8135 0.943 1 0.9302 ADCY7/PIK3CA/DNM2/ARF1/PIK3R1/RAF1/LPAR2/PIK3CD 8 KEGG hsa05202 Transcriptional misregulation in cancer 11/692 193/8135 0.9458 1 0.9302 GADD45A/CCNT1/BCL6/BAK1/CDKN1B/ZBTB17/CDKN1A/REL/NR4A3/FLI1/CDK9 11 KEGG hsa04512 ECM-receptor interaction 4/692 88/8135 0.9487 1 0.9302 COL1A1/ITGA10/COL6A2/THBS1 4 KEGG hsa04015 Rap1 signaling pathway 12/692 210/8135 0.9514 1 0.9302 ADCY7/PIK3CA/FGF9/CTNND1/THBS1/CTNNB1/PIK3R1/RAF1/RGS14/LPAR2/PIK3CD/RAPGEF2 12 KEGG hsa04921 Oxytocin signaling pathway 8/692 154/8135 0.9571 1 0.9302 PRKAB1/ADCY7/CCND1/MYLK4/CAMK2D/CDKN1A/PPP3R1/RAF1 8 KEGG hsa04621 NOD-like receptor signaling pathway 10/692 184/8135 0.9574 1 0.9302 FADD/TNFAIP3/CASR/PANX1/GABARAPL1/NFKBIA/SHARPIN/NFKBIB/TRAF3/NAIP 10 KEGG hsa00512 Mucin type O-glycan biosynthesis 1/692 36/8135 0.9595 1 0.9302 B3GNT3 1 KEGG hsa04918 Thyroid hormone synthesis 3/692 75/8135 0.96 1 0.9302 ATF4/ADCY7/ATP1A3 3 KEGG hsa03008 Ribosome biogenesis in eukaryotes 5/692 109/8135 0.9609 1 0.9302 IMP4/WDR43/RPP38/GNL3/NOL6 5 KEGG hsa04970 Salivary secretion 4/692 93/8135 0.9621 1 0.9302 ADCY7/ATP1A3/HTN3/PRH1 4 KEGG hsa04014 Ras signaling pathway 13/692 232/8135 0.9644 1 0.9302 PIK3CA/FGF9/NF1/REL/RASA4/GNG4/PIK3R1/RAF1/ETS2/BRAP/TGFA/PIK3CD/PLA2G2A 13 KEGG hsa05340 Primary immunodeficiency 1/692 38/8135 0.9662 1 0.9302 LCK 1 KEGG hsa04613 Neutrophil extracellular trap formation 10/692 190/8135 0.9675 1 0.9302 PIK3CA/CR1/NCF1/PPIF/PIK3R1/RAF1/SLC25A6/HDAC4/PIK3CD/C5 10 KEGG hsa00140 Steroid hormone biosynthesis 2/692 61/8135 0.971 1 0.9302 HSD11B1/AKR1C1 2 KEGG hsa04060 Cytokine-cytokine receptor interaction 17/692 295/8135 0.9716 1 0.9302 TNFRSF6B/CXCR4/IL21R/TNFRSF10B/OSM/TNFRSF14/BMP3/EPOR/PPBP/TNFRSF11B/IL12A/IL13/IL20/IL34/CNTF/INHBC/BMP8B 17 KEGG hsa04114 Oocyte meiosis 6/692 131/8135 0.9718 1 0.9302 ADCY7/AURKA/CAMK2D/REC8/PPP3R1/YWHAG 6 KEGG hsa05206 MicroRNAs in cancer 18/692 310/8135 0.9725 1 0.9302 PIM1/SLC7A1/BAK1/PIK3CA/CCND1/CDKN1B/EZR/UBE2I/CCNG1/BMF/CDKN1A/THBS1/PIK3R1/RAF1/HDAC4/PIK3CD/RPS6KA5/CREBBP 18 KEGG hsa04640 Hematopoietic cell lineage 4/692 99/8135 0.9738 1 0.9302 HLA-DRB1/EPOR/CR1/HLA-DQA1 4 KEGG hsa04020 Calcium signaling pathway 13/692 240/8135 0.9746 1 0.9302 CXCR4/ADCY7/HTR6/MYLK4/CAMK2D/FGF9/PPP3R1/DRD1/TNNC2/PPIF/SLC25A6/TACR2/STIM1 13 KEGG hsa04972 Pancreatic secretion 4/692 102/8135 0.9783 1 0.9302 CTRL/ADCY7/ATP1A3/PLA2G2A 4 KEGG hsa04975 Fat digestion and absorption 1/692 43/8135 0.9784 1 0.9302 PLA2G2A 1 KEGG hsa01240 Biosynthesis of cofactors 7/692 153/8135 0.9796 1 0.9302 PDXP/UGDH/AK1/AK3/LIPT1/QPRT/DLD 7 KEGG hsa05135 Yersinia infection 6/692 137/8135 0.9798 1 0.9302 PIK3CA/NFKBIA/PIK3R1/MAP2K7/PIK3CD/LCK 6 KEGG hsa04727 GABAergic synapse 3/692 89/8135 0.9846 1 0.9302 ADCY7/GABARAPL1/GNG4 3 KEGG hsa04137 Mitophagy - animal 2/692 72/8135 0.9875 1 0.9302 ATF4/GABARAPL1 2 KEGG hsa04723 Retrograde endocannabinoid signaling 6/692 148/8135 0.9893 1 0.9302 NDUFS1/ADCY7/NDUFA7/GNG4/NDUFA11/NDUFS3 6 KEGG hsa04728 Dopaminergic synapse 5/692 132/8135 0.9901 1 0.9302 ATF4/CAMK2D/ARRB2/DRD1/GNG4 5 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 2/692 77/8135 0.9915 1 0.9302 ITGA10/CTNNB1 2 KEGG hsa04730 Long-term depression 1/692 60/8135 0.9953 1 0.9302 RAF1 1 KEGG hsa04742 Taste transduction 2/692 86/8135 0.9958 1 0.9302 TAS2R43/SCN9A 2 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 5/692 150/8135 0.9969 1 0.9302 ATF4/ADCY7/CAMK2D/ATP1A3/RPS6KA5 5 KEGG hsa05410 Hypertrophic cardiomyopathy 2/692 90/8135 0.997 1 0.9302 PRKAB1/ITGA10 2 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/692 66/8135 0.9972 1 0.9302 QRSL1 1 KEGG hsa04724 Glutamatergic synapse 3/692 114/8135 0.9975 1 0.9302 ADCY7/PPP3R1/GNG4 3 KEGG hsa05322 Systemic lupus erythematosus 4/692 136/8135 0.9978 1 0.9302 HLA-DRB1/SNRPB/HLA-DQA1/C5 4 KEGG hsa05414 Dilated cardiomyopathy 2/692 96/8135 0.9981 1 0.9302 ADCY7/ITGA10 2 KEGG hsa05034 Alcoholism 6/692 187/8135 0.9991 1 0.9302 ATF4/FOSB/DRD1/GNG4/RAF1/HDAC4 6 KEGG hsa04080 Neuroactive ligand-receptor interaction 13/692 353/8135 0.9999 1 0.9302 PTGER4/NR3C1/GNRH1/HTR6/PTGIR/DRD1/S1PR5/LPAR2/CHRM4/TACR2/EDN2/CHRNA10/C5 13 KEGG hsa04740 Olfactory transduction 12/692 440/8135 1 1 0.9302 OR2T3/OR2L8/CAMK2D/ARRB2/OR4D1/OR4M1/OR13F1/OR1B1/OR10A2/OR1J1/OR10C1/NCALD 12