ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05168 Herpes simplex virus 1 infection 101/1001 495/8135 8.862e-08 2.916e-05 2.668e-05 CASP9/ZNF568/ZNF404/ZNF74/ZNF805/ZNF175/ZNF7/ZNF420/ZNF441/ZNF585A/OAS2/ZNF718/ZNF382/DDX58/ZNF790/SRSF1/ZNF473/ZNF350/HLA-G/NFKBIA/ZNF669/IKBKE/ZNF30/ZNF708/ZNF248/DAXX/ZNF442/ZNF33B/ZNF430/ZNF257/SRSF5/MAP3K7/ZNF527/ZNF8/ZNF689/ZNF461/BCL2L1/ZNF785/ZNF486/ZNF546/SOCS3/BST2/ZNF431/ZNF777/IRF7/ZNF596/ZNF331/ZNF37A/ZNF613/ZNF490/PILRB/ZNF223/ZNF791/TSC1/ZNF107/HLA-A/BID/PIK3R2/TRAF2/ZNF419/ZNF267/ZNF136/ZNF773/ZNF584/ZNF234/ZNF749/IKBKB/ZNF793/ZNF43/HLA-DMB/ZNF616/OAS1/ZNF12/ZNF460/ZNF674/IL1B/ZNF284/TRAF3/ZNF432/RBAK/ZNF211/IFNA16/ZNF761/SP100/HLA-B/ZNF549/ZNF766/ZNF226/LTA/ZNF26/ZNF786/ZNF736/RNASEL/PIK3CA/ZNF764/APAF1/ZNF212/ZNF225/ZNF780A/ZNF317/ZNF850 101 KEGG hsa04210 Apoptosis 35/1001 136/8135 1.248e-05 0.002053 0.001879 CASP9/ENDOG/NFKBIA/ATF4/CASP10/DAXX/CASP2/GADD45A/BCL2L1/TNFSF10/CTSF/CFLAR/TNFRSF10B/MAP2K1/CASP6/BID/PIK3R2/TRAF2/IKBKB/DDIT3/PMAIP1/JUN/CTSW/ACTG1/BBC3/PARP1/FOS/CTSH/DFFA/PIK3CA/CASP7/TUBA1A/IL3/APAF1/PARP4 35 KEGG hsa05164 Influenza A 37/1001 171/8135 0.0003694 0.03102 0.02838 CDK4/CASP9/OAS2/DDX58/NFKBIA/HNRNPUL1/IKBKE/KPNA5/TNFSF10/CASP1/SOCS3/RAE1/TNFRSF10B/SLC25A4/MAP2K1/IRF7/NUP98/BID/PIK3R2/PYCARD/IKBKB/HLA-DMB/OAS1/NLRP3/ACTG1/IL1B/TRAF3/NFKBIB/CCND3/FDPS/IFNA16/RSAD2/TRIM25/RNASEL/PIK3CA/APAF1/NXT1 37 KEGG hsa05169 Epstein-Barr virus infection 42/1001 202/8135 0.0003771 0.03102 0.02838 CDK4/CASP9/OAS2/DDX58/NFKBIE/HLA-G/NFKBIA/IKBKE/HDAC2/MAP3K7/SKP2/CIR1/GADD45A/CDK2/IRF7/NCOR2/HLA-A/TNFAIP3/BID/PIK3R2/TRAF2/ISG15/IKBKB/HLA-DMB/OAS1/JUN/PSMC6/CDKN1B/TRAF3/NFKBIB/CDKN1A/CCND3/IFNA16/DDB2/HDAC1/HLA-B/MYC/PSMD1/PIK3CA/PSMD7/VIM/APAF1 42 KEGG hsa05162 Measles 31/1001 139/8135 0.0006283 0.04134 0.03783 CD46/CDK4/CASP9/HSPA1L/HSPA1A/OAS2/DDX58/NFKBIA/IKBKE/MAP3K7/BCL2L1/CDK2/IRF7/TNFAIP3/BID/PIK3R2/IKBKB/IL2RG/OAS1/JUN/HSPA8/CDKN1B/IL1B/BBC3/TRAF3/NFKBIB/FOS/CCND3/IFNA16/PIK3CA/APAF1 31 KEGG hsa05134 Legionellosis 16/1001 57/8135 0.001044 0.05722 0.05236 CASP9/HSPA1L/HSPA1A/NFKBIA/CR1/BNIP3/CASP1/PYCARD/NAIP/HSPD1/HSPA8/IL1B/RAB1B/SEC22B/CASP7/APAF1 16 KEGG hsa05210 Colorectal cancer 21/1001 86/8135 0.001381 0.05822 0.05328 CASP9/RAC2/AREG/RPS6KB2/RALB/GADD45A/MAP2K1/MSH6/PIK3R2/PMAIP1/JUN/MSH2/SOS1/BBC3/FOS/CDKN1A/TGFA/DDB2/ARAF/MYC/PIK3CA 21 KEGG hsa05417 Lipid and atherosclerosis 42/1001 215/8135 0.001416 0.05822 0.05328 CASP9/HSPA1L/HSPA1A/NFKBIA/IKBKE/ATF4/RXRB/VAV1/PLCG1/MAP3K7/BCL2L1/TNFSF10/CASP1/TNFRSF10B/IRF7/CASP6/BID/PIK3R2/TRAF2/PYCARD/CALM3/IKBKB/DDIT3/CYP2J2/HSPD1/JUN/HSPA8/NLRP3/IL1B/TRAF3/FOS/IFNA16/CALML4/MIB2/CAMK2D/PPP3R2/PIK3CA/CASP7/HSPA5/ABCA1/APAF1/MMP9 42 KEGG hsa03018 RNA degradation 19/1001 79/8135 0.002759 0.1008 0.09228 BTG2/EDC3/DCP2/MPHOSPH6/TTC37/ENO2/EXOSC5/CNOT3/EXOSC3/DDX6/PFKP/CNOT8/HSPD1/WDR61/TOB2/C1D/DCP1A/EXOSC1/ENO1 19 KEGG hsa05222 Small cell lung cancer 21/1001 92/8135 0.003347 0.1076 0.09847 CDK4/CASP9/NFKBIA/RXRB/TRAF4/SKP2/GADD45A/BCL2L1/ITGA3/CDK2/PIK3R2/TRAF2/IKBKB/CDKN2B/CDKN1B/TRAF3/CDKN1A/DDB2/MYC/PIK3CA/APAF1 21 KEGG hsa05220 Chronic myeloid leukemia 18/1001 76/8135 0.004202 0.1076 0.09847 CDK4/NFKBIA/HDAC2/GADD45A/BCL2L1/MAP2K1/PIK3R2/IKBKB/CRK/SOS1/CDKN1B/CDKN1A/DDB2/HDAC1/ARAF/GAB2/MYC/PIK3CA 18 KEGG hsa04668 TNF signaling pathway 24/1001 112/8135 0.00428 0.1076 0.09847 BCL3/NFKBIA/ATF4/CASP10/MAP3K7/CFLAR/SOCS3/JUNB/MAP2K1/TNFAIP3/PIK3R2/TRAF2/IKBKB/JUN/CREB3L3/CXCL5/IL1B/TRAF3/FOS/IRF1/LTA/PIK3CA/CASP7/MMP9 24 KEGG hsa04657 IL-17 signaling pathway 21/1001 94/8135 0.004382 0.1076 0.09847 SRSF1/JUND/NFKBIA/IKBKE/MAP3K7/TRAF4/IL13/TNFAIP3/TRAF2/S100A9/ELAVL1/IL17RA/IKBKB/JUN/CXCL5/IL1B/TRAF3/FOS/FOSB/IL17C/MMP9 21 KEGG hsa05132 Salmonella infection 45/1001 249/8135 0.004743 0.1076 0.09847 FBXO22/ABI1/MYL5/M6PR/NFKBIA/DYNLT1/MAP3K7/DYNLL1/TNFSF10/CASP1/ACTR1A/TNFRSF10B/EXOC2/MAP2K1/ARPC1B/TRAF2/PYCARD/NAIP/KLC1/IKBKB/JUN/CYFIP1/NLRP3/MYL12A/DCTN4/ACTG1/IL1B/ARPC5/FOS/DYNC1LI2/CYTH2/KLC2/MYC/ACTR10/TUBB1/DCTN6/PIK3CA/ACTR3/GSDMD/CASP7/TUBA1A/FYCO1/CYFIP2/VPS18/DNM2 45 KEGG hsa03410 Base excision repair 10/1001 33/8135 0.004906 0.1076 0.09847 APEX2/POLL/POLD2/XRCC1/OGG1/PARP1/FEN1/POLB/NTHL1/PARP4 10 KEGG hsa01524 Platinum drug resistance 17/1001 73/8135 0.006373 0.1233 0.1129 CASP9/BCL2L1/MSH6/BID/PIK3R2/PMAIP1/POLH/MSH2/GSTM1/BBC3/CDKN1A/PIK3CA/GSTA4/GSTM4/ERBB2/APAF1/GSTT1 17 KEGG hsa04115 p53 signaling pathway 17/1001 73/8135 0.006373 0.1233 0.1129 CDK4/CASP9/SHISA5/GADD45A/BCL2L1/CDK2/TNFRSF10B/BID/GORAB/SIVA1/PMAIP1/BBC3/CDKN1A/CCND3/DDB2/CHEK2/APAF1 17 KEGG hsa05160 Hepatitis C 30/1001 157/8135 0.008816 0.1515 0.1387 CDK4/CLDN15/CASP9/IFIT1/OAS2/DDX58/NFKBIA/IKBKE/CFLAR/SOCS3/CDK2/MAP2K1/IRF7/YWHAE/BID/PIK3R2/TRAF2/IKBKB/OAS1/SOS1/TRAF3/CDKN1A/IFNA16/ARAF/RSAD2/MYC/RNASEL/PIK3CA/APAF1/PPP2R2A 30 KEGG hsa03030 DNA replication 10/1001 36/8135 0.00957 0.1515 0.1387 PRIM1/RNASEH1/RNASEH2A/POLD2/RFC4/MCM3/RPA2/RNASEH2C/FEN1/MCM7 10 KEGG hsa05230 Central carbon metabolism in cancer 16/1001 70/8135 0.009623 0.1515 0.1387 PDHA1/PGAM4/GLS/HK1/MAP2K1/PFKP/PIK3R2/SLC7A5/SLC1A5/SLC2A1/MYC/HK2/PIK3CA/ERBB2/SCO2/HKDC1 16 KEGG hsa05212 Pancreatic cancer 17/1001 76/8135 0.009672 0.1515 0.1387 CDK4/CASP9/RAC2/RPS6KB2/RALB/GADD45A/BCL2L1/MAP2K1/PIK3R2/IKBKB/RALBP1/CDKN1A/TGFA/DDB2/ARAF/PIK3CA/ERBB2 17 KEGG hsa01250 Biosynthesis of nucleotide sugars 10/1001 37/8135 0.01171 0.1751 0.1602 NAGK/UGDH/GNE/HK1/GFPT2/GALK2/PGM2/NANS/HK2/HKDC1 10 KEGG hsa05130 Pathogenic Escherichia coli infection 35/1001 197/8135 0.01524 0.218 0.1995 PTPN6/ABI1/CLDN15/CASP9/NFKBIA/ARHGEF2/MAP3K7/TNFSF10/CASP1/TNFRSF10B/ARPC1B/BAIAP2/TRAF2/PYCARD/NAIP/WIPF2/FYN/IKBKB/JUN/CYFIP1/NLRP3/ACTG1/IL1B/ARPC5/NFKBIB/FOS/CYTH2/TUBB1/ABCF2/ACTR3/CASP7/TUBA1A/CYFIP2/MYO1E/LPAR2 35 KEGG hsa01230 Biosynthesis of amino acids 16/1001 75/8135 0.01846 0.2396 0.2192 MAT2A/PYCR2/RPE/PSPH/PGAM4/TALDO1/MAT2B/ENO2/PFKP/PSAT1/TKTL1/ALDH18A1/PRPS1L1/ASS1/PGK2/ENO1 16 KEGG hsa03020 RNA polymerase 9/1001 34/8135 0.01881 0.2396 0.2192 POLR2H/POLR2D/CD3EAP/POLR1B/POLR2E/POLR3H/POLR2C/TWISTNB/POLR2L 9 KEGG hsa04623 Cytosolic DNA-sensing pathway 14/1001 63/8135 0.01893 0.2396 0.2192 DDX58/NFKBIA/IKBKE/POLR2H/CASP1/IRF7/PYCARD/IKBKB/IL1B/NFKBIB/IFNA16/POLR2E/POLR3H/POLR2L 14 KEGG hsa04146 Peroxisome 17/1001 82/8135 0.02025 0.2468 0.2258 MPV17/PEX6/PEX11B/MVK/HSD17B4/ECI2/PECR/PMVK/HMGCL/ABCD3/PEX10/PEX11G/DHRS4/PRDX5/SLC25A17/PEX12/AMACR 17 KEGG hsa05161 Hepatitis B 29/1001 162/8135 0.02326 0.2668 0.2442 CASP9/DDB1/DDX58/NFKBIA/STAT6/IKBKE/ATF4/CASP10/MAP3K7/CDK2/MAP2K1/IRF7/BID/PIK3R2/EGR2/IKBKB/JUN/SOS1/CREB3L3/TRAF3/FOS/CDKN1A/IFNA16/DDB2/ARAF/MYC/PIK3CA/APAF1/MMP9 29 KEGG hsa04066 HIF-1 signaling pathway 21/1001 109/8135 0.02352 0.2668 0.2442 EGLN2/PDHA1/PLCG1/RPS6KB2/HK1/ENO2/PFKFB3/MAP2K1/PFKP/PIK3R2/CDKN1B/CDKN1A/SLC2A1/CAMK2D/HK2/PIK3CA/ERBB2/PGK2/MKNK2/ENO1/HKDC1 21 KEGG hsa00030 Pentose phosphate pathway 8/1001 30/8135 0.02505 0.2747 0.2513 RPE/H6PD/TALDO1/PFKP/TKTL1/PGM2/PRPS1L1/IDNK 8 KEGG hsa04910 Insulin signaling pathway 25/1001 137/8135 0.02703 0.2868 0.2625 PPP1R3B/LIPE/PPP1R3F/RPS6KB2/HK1/PRKCI/SOCS3/MAP2K1/PRKAG2/TSC1/PIK3R2/CALM3/IKBKB/PTPN1/CRK/SOS1/ACACB/ARAF/CALML4/SOCS4/HK2/PIK3CA/PRKAR2B/MKNK2/HKDC1 25 KEGG hsa00562 Inositol phosphate metabolism 15/1001 73/8135 0.03025 0.311 0.2846 PLCG1/INPP5B/PI4K2A/FIG4/MTMR1/PLCD1/SYNJ2/PLCH2/IMPA2/MINPP1/PIK3CA/IMPA1/CDIPT/ITPKC/PIP4K2B 15 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 11/1001 49/8135 0.03288 0.3277 0.2999 NAGK/UGDH/GNE/HK1/GFPT2/GALK2/PGM2/NANS/HK2/HKDC1/GNPDA1 11 KEGG hsa04144 Endocytosis 41/1001 251/8135 0.03387 0.3277 0.2999 HSPA1L/HSPA1A/HLA-G/ACAP1/LDLRAP1/RAB10/AGAP2/PRKCI/AP2S1/GRK6/VPS37D/PARD6G/RAB31/RAB11FIP4/ARPC1B/HLA-A/WIPF2/VPS36/ZFYVE27/PARD6A/CXCR4/VPS37B/CHMP1B/IL2RG/VTA1/HSPA8/CHMP2B/BIN1/ARPC5/VPS45/HLA-B/CYTH2/ARFGAP2/IQSEC2/ASAP2/AP2A2/ACTR3/PARD6B/EHD3/PSD4/DNM2 41 KEGG hsa04215 Apoptosis - multiple species 8/1001 32/8135 0.03612 0.3395 0.3106 CASP9/BCL2L1/BID/PMAIP1/BBC3/NGFR/CASP7/APAF1 8 KEGG hsa05203 Viral carcinogenesis 34/1001 204/8135 0.03896 0.3545 0.3244 CDK4/DDB1/HLA-G/NFKBIA/GTF2H4/ATF4/CHD4/HDAC2/SRF/SKP2/HDAC7/CDK2/IRF7/YWHAE/HLA-A/PIK3R2/EGR2/TRAF2/CDKN2B/PMAIP1/JUN/CREB3L3/CDKN1B/TRAF3/CDKN1A/CCND3/HDAC1/SP100/HLA-B/DNAJA3/REL/POLB/PIK3CA/MRPS18B 34 KEGG hsa04662 B cell receptor signaling pathway 16/1001 82/8135 0.03987 0.3545 0.3244 PTPN6/RAC2/CD79B/NFKBIE/NFKBIA/VAV1/MAP2K1/PIK3R2/IKBKB/JUN/SOS1/NFKBIB/FOS/PPP3R2/PIK3CA/LILRB3 16 KEGG hsa04621 NOD-like receptor signaling pathway 31/1001 184/8135 0.04146 0.359 0.3285 OAS2/NFKBIA/IKBKE/GBP1/CARD6/NEK7/MAP3K7/BCL2L1/CASP1/TRPV2/IRF7/YWHAE/TP53BP1/TNFAIP3/TRAF2/PYCARD/NAIP/IKBKB/OAS1/JUN/NLRP3/IL1B/TRAF3/NFKBIB/GABARAPL1/IFNA16/GBP4/RBCK1/RNASEL/GSDMD/DHX33 31 KEGG hsa05135 Yersinia infection 24/1001 137/8135 0.04561 0.3816 0.3492 RAC2/NFKBIA/VAV1/PLCG1/RPS6KA1/MAP3K7/CASP1/MAP2K1/ARPC1B/BAIAP2/PIK3R2/TRAF2/PYCARD/WIPF2/IKBKB/JUN/NLRP3/CRK/ACTG1/IL1B/ARPC5/FOS/PIK3CA/ACTR3 24 KEGG hsa05213 Endometrial cancer 12/1001 58/8135 0.04711 0.3816 0.3492 CASP9/GADD45A/ILK/MAP2K1/PIK3R2/SOS1/CDKN1A/DDB2/ARAF/MYC/PIK3CA/ERBB2 12 KEGG hsa04660 T cell receptor signaling pathway 19/1001 104/8135 0.04883 0.3816 0.3492 PTPN6/CDK4/NFKBIE/NFKBIA/VAV1/PLCG1/MAP3K7/MAP2K1/PRKCQ/PIK3R2/FYN/IKBKB/JUN/SOS1/NFKBIB/FOS/PPP3R2/PIK3CA/ITK 19 KEGG hsa04010 MAPK signaling pathway 46/1001 294/8135 0.04925 0.3816 0.3492 HSPA1L/HSPA1A/DUSP8/RAC2/DUSP7/JUND/MAP4K2/ATF4/DAXX/MAPKAPK3/CDC25B/RPS6KA1/AREG/SRF/MAP3K7/MAPK8IP3/GADD45A/DUSP1/MAP2K1/MAPK8IP2/TRAF2/RAPGEF2/MAP3K12/PPM1B/IKBKB/DDIT3/JUN/HSPA8/CRK/SOS1/IL1B/MAP3K3/FOS/TGFA/ARAF/MAP3K11/MAPK8IP1/NGFR/MYC/FLT4/PPP3R2/ERBB2/PLA2G4B/MKNK2/DUSP10/DUSP2 46 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 32/1001 194/8135 0.04987 0.3816 0.3492 CDK4/CASP9/HLA-G/NFKBIA/ATG14/IKBKE/PLCG1/MAP2K1/IRF7/ZFP36/HLA-A/BID/PIK3R2/TRAF2/CALM3/IKBKB/CD200R1/JUN/TRAF3/FOS/CDKN1A/PIK3R5/IFNA16/CALML4/HLA-B/MYC/MICA/GNG8/PPP3R2/RCAN1/PIK3CA/GNG4 32 KEGG hsa04012 ErbB signaling pathway 16/1001 85/8135 0.0531 0.392 0.3587 PLCG1/AREG/RPS6KB2/MAP2K1/PIK3R2/JUN/CRK/SOS1/CDKN1B/CDKN1A/TGFA/ARAF/MYC/CAMK2D/PIK3CA/ERBB2 16 KEGG hsa05223 Non-small cell lung cancer 14/1001 72/8135 0.05362 0.392 0.3587 CDK4/CASP9/RXRB/PLCG1/GADD45A/MAP2K1/PIK3R2/SOS1/CDKN1A/TGFA/DDB2/ARAF/PIK3CA/ERBB2 14 KEGG hsa04110 Cell cycle 22/1001 126/8135 0.05559 0.3976 0.3638 CDK4/STAG2/ANAPC7/DBF4/CDKN2D/HDAC2/CDC25B/SKP2/GADD45A/CDK2/MCM3/YWHAE/CDKN2B/CDKN1B/CDKN1A/CCND3/SMC3/HDAC1/ORC6/CHEK2/MYC/MCM7 22 KEGG hsa05416 Viral myocarditis 12/1001 60/8135 0.05893 0.404 0.3697 CASP9/RAC2/HLA-G/CD55/HLA-A/BID/FYN/HLA-DMB/ACTG1/EIF4G2/HLA-B/CD80 12 KEGG hsa05131 Shigellosis 39/1001 247/8135 0.05894 0.404 0.3697 MYL5/GSK3A/NFKBIA/ATG14/ARHGEF2/PLCG1/RPS6KB2/HK1/MAP3K7/BNIP3/PPID/BCL2L1/CASP1/ILK/PRKCQ/ARPC1B/PIK3R2/TRAF2/PYCARD/NAIP/IKBKB/JUN/NLRP3/CRK/MYL12A/PLCD1/ACTG1/IL1B/ARPC5/NFKBIB/CYTH2/CBX3/RBCK1/HK2/PIK3CA/ACTR3/UBE2D4/HKDC1/U2AF1 39 KEGG hsa00010 Glycolysis / Gluconeogenesis 13/1001 67/8135 0.06232 0.4101 0.3753 PDHA1/PGAM4/HK1/ENO2/PFKP/ACSS1/ALDH7A1/PGM2/MINPP1/HK2/PGK2/ENO1/HKDC1 13 KEGG hsa05221 Acute myeloid leukemia 13/1001 67/8135 0.06232 0.4101 0.3753 PIM1/RPS6KB2/RARA/MAP2K1/PIK3R2/IKBKB/SOS1/JUP/ARAF/MYC/PIK3CA/PIM2/IL3 13 KEGG hsa04659 Th17 cell differentiation 19/1001 108/8135 0.06718 0.4334 0.3966 NFKBIE/NFKBIA/STAT6/RXRB/PLCG1/IL27RA/RARA/PRKCQ/RORA/IKBKB/HLA-DMB/IL2RG/IL4R/JUN/IL1B/NFKBIB/FOS/PPP3R2/IL23R 19 KEGG hsa04664 Fc epsilon RI signaling pathway 13/1001 68/8135 0.06878 0.4352 0.3982 RAC2/VAV1/PLCG1/IL13/MAP2K1/ALOX5/PIK3R2/FYN/SOS1/GAB2/PIK3CA/IL3/PLA2G4B 13 KEGG hsa05214 Glioma 14/1001 75/8135 0.07139 0.4431 0.4055 CDK4/PLCG1/GADD45A/MAP2K1/PIK3R2/CALM3/SOS1/CDKN1A/TGFA/DDB2/ARAF/CALML4/CAMK2D/PIK3CA 14 KEGG hsa04920 Adipocytokine signaling pathway 13/1001 69/8135 0.07566 0.4605 0.4214 NFKBIE/NFKBIA/RXRB/SOCS3/PRKAG2/PRKCQ/TRAF2/IKBKB/ADIPOR2/NFKBIB/SLC2A1/ACACB/CPT1C 13 KEGG hsa04068 FoxO signaling pathway 22/1001 131/8135 0.07869 0.4605 0.4214 CDKN2D/BCL6/AGAP2/PRMT1/FBXO32/SKP2/BNIP3/GADD45A/TNFSF10/CDK2/MAP2K1/PRKAG2/PIK3R2/IKBKB/PLK4/CDKN2B/SOS1/CDKN1B/CDKN1A/GABARAPL1/ARAF/PIK3CA 22 KEGG hsa04650 Natural killer cell mediated cytotoxicity 22/1001 131/8135 0.07869 0.4605 0.4214 PTPN6/ICAM2/RAC2/HLA-G/VAV1/PLCG1/TNFSF10/TNFRSF10B/MAP2K1/HLA-A/BID/PIK3R2/FYN/SOS1/IFNA16/ARAF/HLA-B/ULBP2/MICA/PPP3R2/PIK3CA/SH2D1A 22 KEGG hsa03250 Viral life cycle - HIV-1 12/1001 63/8135 0.08011 0.4605 0.4214 SMARCB1/CCNT1/SERINC3/MAP1S/MAP1A/BST2/FURIN/CXCR4/APOBEC3F/MLLT1/CPSF7/SUPT5H 12 KEGG hsa04070 Phosphatidylinositol signaling system 17/1001 97/8135 0.08246 0.4605 0.4214 PLCG1/INPP5B/PI4K2A/PIK3R2/CALM3/MTMR1/PLCD1/DGKA/SYNJ2/CALML4/DGKD/IMPA2/PIK3CA/IMPA1/CDIPT/ITPKC/PIP4K2B 17 KEGG hsa04622 RIG-I-like receptor signaling pathway 13/1001 70/8135 0.08297 0.4605 0.4214 DDX58/NFKBIA/IKBKE/CASP10/MAP3K7/IRF7/TRAF2/ISG15/IKBKB/TRAF3/NFKBIB/IFNA16/TRIM25 13 KEGG hsa04142 Lysosome 22/1001 132/8135 0.08399 0.4605 0.4214 HYAL3/HYAL2/M6PR/GM2A/CTSF/CTNS/ASAH1/GBA/CTSA/CD164/SMPD1/CTSW/SLC11A2/AP1S2/SUMF1/NAGA/CTSH/ACP5/GGA1/AP4B1/TPP1/CLN5 22 KEGG hsa03040 Spliceosome 24/1001 147/8135 0.08866 0.4617 0.4225 TCERG1/HSPA1L/HSPA1A/SF3A1/SRSF1/BCAS2/DDX39B/CHERP/SRSF5/SNRPA1/SLU7/HSPA8/XAB2/PPIL1/SNRNP70/PHF5A/RBMX/PCBP1/HNRNPA1L2/DHX8/SF3B4/THOC2/TXNL4A/U2AF1 24 KEGG hsa01522 Endocrine resistance 17/1001 98/8135 0.08891 0.4617 0.4225 CDK4/RPS6KB2/MAP2K1/CARM1/PIK3R2/JAG2/JUN/SOS1/CDKN1B/FOS/CDKN1A/ARAF/SP1/NCOR1/PIK3CA/ERBB2/MMP9 17 KEGG hsa00670 One carbon pool by folate 5/1001 20/8135 0.08985 0.4617 0.4225 MTHFS/GART/MTHFD2L/MTFMT/MTHFD1 5 KEGG hsa04722 Neurotrophin signaling pathway 20/1001 119/8135 0.08985 0.4617 0.4225 NFKBIE/NFKBIA/ATF4/PLCG1/RPS6KA1/MAP2K1/YWHAE/PIK3R2/CALM3/IKBKB/JUN/CRK/SOS1/MAP3K3/NFKBIB/CALML4/NGFR/CAMK2D/PIK3CA/IRAK2 20 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 6/1001 26/8135 0.09121 0.4617 0.4225 PIGA/DPM2/PIGF/PIGL/PIGV/PIGH 6 KEGG hsa04152 AMPK signaling pathway 20/1001 120/8135 0.09598 0.4785 0.4378 STRADB/LIPE/RAB10/RPS6KB2/MAP3K7/PFKFB3/PFKFB4/PRKAG2/TSC1/PFKP/PIK3R2/ELAVL1/ADIPOR2/CREB3L3/HMGCR/ACACB/ULK1/PIK3CA/CPT1C/PPP2R2A 20 KEGG hsa04380 Osteoclast differentiation 21/1001 128/8135 0.1019 0.4834 0.4423 JUND/NFKBIA/MAP3K7/SOCS3/JUNB/SIRPG/MAP2K1/PIK3R2/TRAF2/FYN/IKBKB/JUN/IL1B/FOS/FOSB/GAB2/ACP5/PPP3R2/PIK3CA/LILRB3/FOSL2 21 KEGG hsa05166 Human T-cell leukemia virus 1 infection 34/1001 222/8135 0.1025 0.4834 0.4423 CDK4/ANAPC7/HLA-G/NFKBIA/ATF4/SRF/BCL2L1/CDK2/SLC25A4/MAP2K1/ZFP36/HLA-A/PIK3R2/EGR2/IKBKB/CDKN2B/HLA-DMB/IL2RG/JUN/TCF3/CREB3L3/MAP3K3/FOS/CDKN1A/CCND3/FDPS/SLC2A1/HLA-B/CHEK2/POLB/MYC/LTA/PPP3R2/PIK3CA 34 KEGG hsa00051 Fructose and mannose metabolism 7/1001 33/8135 0.1027 0.4834 0.4423 HK1/PFKFB3/PFKFB4/PFKP/KHK/HK2/HKDC1 7 KEGG hsa04330 Notch signaling pathway 11/1001 59/8135 0.1028 0.4834 0.4423 APH1B/ATXN1L/HDAC2/CIR1/NCOR2/JAG2/TLE3/HDAC1/DTX3L/NUMBL/NCSTN 11 KEGG hsa01200 Carbon metabolism 19/1001 115/8135 0.1096 0.5025 0.4598 PDHA1/RPE/PSPH/PGAM4/H6PD/HK1/TALDO1/ENO2/PFKP/ACSS1/ECHS1/PSAT1/TKTL1/PRPS1L1/IDNK/HK2/PGK2/ENO1/HKDC1 19 KEGG hsa03013 Nucleocytoplasmic transport 18/1001 108/8135 0.11 0.5025 0.4598 NUP50/TMEM33/IPO13/NUP43/AAAS/DDX19B/DDX39B/KPNA5/GLE1/RAE1/NUP98/SUMO3/SUMO4/TNPO2/THOC6/THOC2/NXT1/TNPO1 18 KEGG hsa03420 Nucleotide excision repair 9/1001 47/8135 0.1164 0.5245 0.4799 DDB1/GTF2H4/POLD2/RFC4/GTF2H5/RPA2/MNAT1/DDB2/ERCC2 9 KEGG hsa00900 Terpenoid backbone biosynthesis 5/1001 22/8135 0.1247 0.5442 0.498 FNTB/MVK/PMVK/HMGCR/FDPS 5 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 15/1001 89/8135 0.1266 0.5442 0.498 PTPN6/NFKBIE/NFKBIA/PLCG1/RPS6KB2/MAP2K1/PRKCQ/PIK3R2/IKBKB/JUN/MAP3K3/NFKBIB/FOS/PPP3R2/PIK3CA 15 KEGG hsa05225 Hepatocellular carcinoma 26/1001 168/8135 0.1274 0.5442 0.498 CDK4/SMARCB1/ACTL6A/FZD6/PLCG1/RPS6KB2/GADD45A/BCL2L1/MAP2K1/WNT10A/PIK3R2/SOS1/GSTM1/ACTG1/CDKN1A/TGFA/DDB2/ARAF/MYC/ARID1B/PIK3CA/GSTA4/GSTM4/GSTT1/FZD3/PHF10 26 KEGG hsa05418 Fluid shear stress and atherosclerosis 22/1001 139/8135 0.1276 0.5442 0.498 RAC2/ARHGEF2/MAP3K7/DUSP1/PIK3R2/SUMO3/SUMO4/CALM3/IKBKB/JUN/GSTM1/ACTG1/IL1B/FOS/CALML4/ASS1/PIK3CA/GSTA4/GSTM4/MMP9/GSTT1/PIAS4 22 KEGG hsa04064 NF-kappa B signaling pathway 17/1001 104/8135 0.1342 0.5442 0.498 DDX58/NFKBIA/PLCG1/MAP3K7/GADD45A/BCL2L1/CFLAR/PRKCQ/TNFAIP3/TRAF2/IKBKB/IL1B/PARP1/TRAF3/TRIM25/LTA/PIAS4 17 KEGG hsa04666 Fc gamma R-mediated phagocytosis 16/1001 97/8135 0.135 0.5442 0.498 RAC2/VAV1/PLCG1/RPS6KB2/MAP2K1/ARPC1B/PIK3R2/CRK/BIN1/ARPC5/GAB2/ASAP2/PIK3CA/ACTR3/PLA2G4B/DNM2 16 KEGG hsa05215 Prostate cancer 16/1001 97/8135 0.135 0.5442 0.498 CASP9/NFKBIA/ATF4/CDK2/MAP2K1/PIK3R2/IKBKB/SOS1/CREB3L3/CDKN1B/CDKN1A/TGFA/ARAF/PIK3CA/ERBB2/MMP9 16 KEGG hsa05031 Amphetamine addiction 12/1001 69/8135 0.1353 0.5442 0.498 ATF4/HDAC2/CALM3/JUN/CREB3L3/FOS/FOSB/HDAC1/CALML4/GRIN2C/CAMK2D/PPP3R2 12 KEGG hsa04630 JAK-STAT signaling pathway 25/1001 162/8135 0.1359 0.5442 0.498 CISH/PIM1/PTPN6/STAT6/IL27RA/BCL2L1/SOCS3/IL13/OSM/PIK3R2/IL20RB/IL2RG/IL4R/SOS1/CDKN1A/CCND3/IFNA16/IL10RB/MYC/SOCS4/PIK3CA/IL3/GH1/IL23R/PIAS4 25 KEGG hsa05014 Amyotrophic lateral sclerosis 52/1001 364/8135 0.1373 0.5442 0.498 NUP50/NRBF2/SMCR8/CASP9/ATG14/NUP43/ATF4/DAXX/NDUFA7/GLE1/NDUFS7/BCL2L1/CASP1/ACTR1A/RAE1/PSMA5/DNAL4/NUP98/FIG4/BID/TRAF2/KLC1/UBQLN4/DDIT3/NEFH/DCTN4/PSMC6/ACTG1/CHMP2B/NDUFA8/ATG2A/KLC2/PSMD1/NDUFB5/GRIN2C/ACTR10/HNRNPA1L2/TUBB1/DCTN6/PPP3R2/DNAH6/ULK1/PSMD7/CCS/HSPA5/TUBA1A/GPX1/APAF1/UQCRFS1/NXT1/PSMB3/NDUFA12 52 KEGG hsa04140 Autophagy - animal 22/1001 141/8135 0.1422 0.5462 0.4998 NRBF2/SMCR8/ATG14/TP53INP2/RPS6KB2/MAP3K7/BNIP3/BCL2L1/CFLAR/MAP2K1/PRKCQ/TSC1/PIK3R2/DDIT4/ATG2A/ATG4D/GABARAPL1/ATG4C/ULK1/PIK3CA/UVRAG/ATG10 22 KEGG hsa05231 Choline metabolism in cancer 16/1001 98/8135 0.144 0.5462 0.4998 RAC2/SLC22A5/PLCG1/RPS6KB2/MAP2K1/TSC1/PIK3R2/JUN/SOS1/SLC44A1/DGKA/FOS/SP1/DGKD/PIK3CA/PLA2G4B 16 KEGG hsa03430 Mismatch repair 5/1001 23/8135 0.1441 0.5462 0.4998 POLD2/RFC4/RPA2/MSH6/MSH2 5 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/1001 11/8135 0.1444 0.5462 0.4998 VKORC1/VKORC1L1/GGCX 3 KEGG hsa00760 Nicotinate and nicotinamide metabolism 7/1001 36/8135 0.1462 0.5467 0.5002 NT5E/BST1/NMNAT1/SIRT5/NNT/NT5M/PNP 7 KEGG hsa05016 Huntington disease 44/1001 306/8135 0.15 0.5476 0.5011 NRBF2/CASP9/ATG14/HDAC2/POLR2H/NDUFA7/NDUFS7/AP2S1/ACTR1A/POLR2D/PSMA5/SLC25A4/DNAL4/HTT/TRAF2/KLC1/PPIF/DCTN4/PSMC6/CREB3L3/NDUFA8/BBC3/ATG2A/HDAC1/POLR2E/KLC2/SP1/PSMD1/NDUFB5/ACTR10/TUBB1/DCTN6/POLR2C/AP2A2/DNAH6/ULK1/PSMD7/TUBA1A/GPX1/APAF1/UQCRFS1/PSMB3/NDUFA12/POLR2L 44 KEGG hsa00071 Fatty acid degradation 8/1001 43/8135 0.1515 0.5476 0.5011 CYP2U1/HADHB/CPT2/ECI2/GCDH/ALDH7A1/ECHS1/CPT1C 8 KEGG hsa04940 Type I diabetes mellitus 8/1001 43/8135 0.1515 0.5476 0.5011 HLA-G/HLA-A/HSPD1/HLA-DMB/IL1B/HLA-B/LTA/CD80 8 KEGG hsa04658 Th1 and Th2 cell differentiation 15/1001 92/8135 0.1548 0.5535 0.5065 NFKBIE/NFKBIA/STAT6/PLCG1/IL13/PRKCQ/IKBKB/JAG2/HLA-DMB/IL2RG/IL4R/JUN/NFKBIB/FOS/PPP3R2 15 KEGG hsa01212 Fatty acid metabolism 10/1001 57/8135 0.1565 0.5535 0.5065 HSD17B4/HADHB/CPT2/ECHS1/OXSM/ELOVL7/MCAT/CBR4/CPT1C/FADS2 10 KEGG hsa05163 Human cytomegalovirus infection 33/1001 225/8135 0.1606 0.562 0.5143 CDK4/CASP9/RAC2/HLA-G/NFKBIA/ATF4/RPS6KB2/MAP2K1/PTGER4/TSC1/HLA-A/BID/PIK3R2/TRAF2/CXCR4/CALM3/IKBKB/CRK/SOS1/CREB3L3/IL1B/CDKN1A/IFNA16/CALML4/HLA-B/IL10RB/SP1/MYC/PTGER2/GNG8/PPP3R2/PIK3CA/GNG4 33 KEGG hsa05216 Thyroid cancer 7/1001 37/8135 0.1624 0.5625 0.5147 RXRB/GADD45A/MAP2K1/CCDC6/CDKN1A/DDB2/MYC 7 KEGG hsa04931 Insulin resistance 17/1001 108/8135 0.1705 0.5786 0.5294 PPP1R3B/NFKBIA/RPS6KA1/RPS6KB2/SOCS3/SLC27A4/PRKAG2/PRKCQ/GFPT2/PIK3R2/OGT/IKBKB/PTPN1/CREB3L3/SLC2A1/ACACB/PIK3CA 17 KEGG hsa00061 Fatty acid biosynthesis 4/1001 18/8135 0.1725 0.5786 0.5294 OXSM/ACACB/MCAT/CBR4 4 KEGG hsa05170 Human immunodeficiency virus 1 infection 31/1001 212/8135 0.1739 0.5786 0.5294 CASP9/DDB1/RAC2/HLA-G/NFKBIA/PLCG1/RNF7/RPS6KB2/MAP3K7/BCL2L1/BST2/MAP2K1/HLA-A/BID/PIK3R2/TRAF2/CXCR4/CALM3/IKBKB/JUN/CRK/AP1S2/FOS/IFNA16/CALML4/HLA-B/GNG8/PPP3R2/PIK3CA/APOBEC3F/GNG4 31 KEGG hsa00052 Galactose metabolism 6/1001 31/8135 0.1741 0.5786 0.5294 HK1/PFKP/PGM2/HK2/MGAM/HKDC1 6 KEGG hsa05012 Parkinson disease 38/1001 266/8135 0.1815 0.5932 0.5428 CASP9/ADORA2A/ATF4/DAXX/PLCG1/UBE2J2/NDUFA7/SLC39A14/NDUFS7/BCL2L1/DUSP1/PSMA5/SLC25A4/UBE2L6/KLC1/CALM3/DDIT3/PPIF/PSMC6/SLC39A10/SLC11A2/NDUFA8/CALML4/KLC2/PSMD1/NDUFB5/TUBB1/CAMK2D/PSMD7/UBA1/HSPA5/TUBA1A/APAF1/UQCRFS1/SLC39A1/PSMB3/TRAP1/NDUFA12 38 KEGG hsa03022 Basal transcription factors 8/1001 45/8135 0.1821 0.5932 0.5428 TAF11/GTF2H4/TAF15/GTF2H5/TAF13/MNAT1/GTF2I/ERCC2 8 KEGG hsa04930 Type II diabetes mellitus 8/1001 46/8135 0.1983 0.6364 0.5824 HK1/SOCS3/PIK3R2/IKBKB/SOCS4/HK2/PIK3CA/HKDC1 8 KEGG hsa05202 Transcriptional misregulation in cancer 28/1001 193/8135 0.2003 0.6364 0.5824 MEN1/RXRB/CCNT1/FLI1/HDAC2/TAF15/BCL6/NR4A3/GADD45A/BCL2L1/RARA/ETV7/DDIT3/TCF3/CDKN1B/CDKN1A/DDB2/HDAC1/JUP/REL/SP1/NGFR/MYC/NCOR1/IL3/MMP9/ASPSCR1/MLLT1 28 KEGG hsa04620 Toll-like receptor signaling pathway 16/1001 104/8135 0.2046 0.6364 0.5824 NFKBIA/IKBKE/MAP3K7/MAP2K1/IRF7/PIK3R2/IKBKB/JUN/TLR1/IL1B/TRAF3/FOS/IFNA16/PIK3CA/CD80/TOLLIP 16 KEGG hsa04625 C-type lectin receptor signaling pathway 16/1001 104/8135 0.2046 0.6364 0.5824 BCL3/NFKBIA/IKBKE/CASP1/PIK3R2/EGR2/PYCARD/CALM3/IKBKB/JUN/NLRP3/IL1B/IRF1/CALML4/PPP3R2/PIK3CA 16 KEGG hsa04150 mTOR signaling pathway 23/1001 156/8135 0.205 0.6364 0.5824 STRADB/TTI1/SLC3A2/FZD6/RPS6KA1/RPS6KB2/SKP2/MIOS/LAMTOR2/MAP2K1/WNT10A/TSC1/RICTOR/LPIN2/PIK3R2/DDIT4/SLC7A5/IKBKB/SLC38A9/SOS1/ULK1/PIK3CA/FZD3 23 KEGG hsa03450 Non-homologous end-joining 3/1001 13/8135 0.2089 0.6425 0.5879 POLL/NHEJ1/FEN1 3 KEGG hsa03460 Fanconi anemia pathway 9/1001 54/8135 0.2139 0.65 0.5948 ATRIP/FANCE/TOP3B/TOP3A/RPA2/POLH/RAD51C/RMI2/FANCA 9 KEGG hsa00260 Glycine, serine and threonine metabolism 7/1001 40/8135 0.2153 0.65 0.5948 PSPH/PGAM4/SARDH/ALDH7A1/GNMT/PSAT1/ALAS1 7 KEGG hsa05133 Pertussis 12/1001 76/8135 0.2198 0.6573 0.6015 CASP1/C4B/PYCARD/CALM3/JUN/NLRP3/CXCL5/IL1B/FOS/IRF1/CALML4/CASP7 12 KEGG hsa05211 Renal cell carcinoma 11/1001 69/8135 0.2234 0.6621 0.6059 EGLN2/MAP2K1/PIK3R2/JUN/CRK/SOS1/CDKN1A/TGFA/SLC2A1/ARAF/PIK3CA 11 KEGG hsa04213 Longevity regulating pathway - multiple species 10/1001 62/8135 0.2268 0.6643 0.6079 HSPA1L/HSPA1A/HDAC2/RPS6KB2/PRKAG2/PIK3R2/HSPA8/CLPB/HDAC1/PIK3CA 10 KEGG hsa04919 Thyroid hormone signaling pathway 18/1001 121/8135 0.2284 0.6643 0.6079 CASP9/RXRB/PLCG1/HDAC2/MAP2K1/PFKP/PIK3R2/PLCD1/ACTG1/MED13L/HDAC1/SLC2A1/MYC/ATP2A1/NCOR1/RCAN1/PIK3CA/MED12 18 KEGG hsa04217 Necroptosis 23/1001 159/8135 0.2326 0.6643 0.6079 SPATA2/STAT6/PPID/TNFSF10/CASP1/CFLAR/TNFRSF10B/SLC25A4/TNFAIP3/BID/TRAF2/PYCARD/CHMP1B/SMPD1/NLRP3/CHMP2B/IL1B/PARP1/IFNA16/RBCK1/CAMK2D/PLA2G4B/FAF1 23 KEGG hsa03440 Homologous recombination 7/1001 41/8135 0.2342 0.6643 0.6079 TOP3B/TOP3A/POLD2/RPA2/RAD52/RAD51C/RAD54B 7 KEGG hsa05219 Bladder cancer 7/1001 41/8135 0.2342 0.6643 0.6079 CDK4/MAP2K1/CDKN1A/ARAF/MYC/ERBB2/MMP9 7 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 64/1001 476/8135 0.2368 0.6658 0.6092 NRBF2/SMCR8/CASP9/CDK5/ATG14/ATXN1L/ATF4/DAXX/FZD6/PLCG1/UBE2J2/NDUFA7/PPID/NDUFS7/BCL2L1/ACTR1A/PSMA5/SLC25A4/MAP2K1/DNAL4/WNT10A/FIG4/HTT/BID/TRAF2/UBE2L6/KLC1/CALM3/DDIT3/PPIF/NEFH/DCTN4/PSMC6/CHMP2B/IL1B/NDUFA8/ATG2A/ARAF/CALML4/KLC2/PSMD1/NDUFB5/GRIN2C/ACTR10/TUBB1/DCTN6/CAMK2D/ATP2A1/PPP3R2/DNAH6/ULK1/PSMD7/CCS/UBA1/CASP7/HSPA5/TUBA1A/GPX1/APAF1/UQCRFS1/PSMB3/TRAP1/FZD3/NDUFA12 64 KEGG hsa04932 Non-alcoholic fatty liver disease 22/1001 155/8135 0.2682 0.7477 0.6842 GSK3A/ATF4/NDUFA7/NDUFS7/SOCS3/PRKAG2/BID/PIK3R2/TRAF2/IKBKB/DDIT3/ADIPOR2/JUN/IL1B/NDUFA8/FOS/MAP3K11/NDUFB5/PIK3CA/CASP7/UQCRFS1/NDUFA12 22 KEGG hsa00500 Starch and sucrose metabolism 6/1001 36/8135 0.278 0.7637 0.6988 GBE1/HK1/PGM2/HK2/MGAM/HKDC1 6 KEGG hsa04218 Cellular senescence 22/1001 156/8135 0.2785 0.7637 0.6988 CDK4/HLA-G/PPID/GADD45A/CDK2/SLC25A4/MAP2K1/TSC1/HLA-A/PIK3R2/CALM3/CDKN2B/CDKN1A/LIN9/CCND3/CALML4/HLA-B/CHEK2/MYC/ZFP36L2/PPP3R2/PIK3CA 22 KEGG hsa00340 Histidine metabolism 4/1001 22/8135 0.2826 0.7684 0.7031 ALDH7A1/AMDHD1/HAL/CNDP1 4 KEGG hsa00330 Arginine and proline metabolism 8/1001 51/8135 0.2871 0.7742 0.7084 PYCR2/ODC1/ALDH7A1/SMOX/ALDH18A1/SAT2/CNDP1/OAT 8 KEGG hsa04370 VEGF signaling pathway 9/1001 59/8135 0.298 0.797 0.7293 CASP9/RAC2/PLCG1/MAPKAPK3/MAP2K1/PIK3R2/PPP3R2/PIK3CA/PLA2G4B 9 KEGG hsa05017 Spinocerebellar ataxia 20/1001 143/8135 0.3041 0.8053 0.7369 NRBF2/ATG14/ATXN1L/PSMA5/SLC25A4/PIK3R2/TRAF2/RORA/PPIF/PSMC6/ATG2A/SP1/NOP56/PSMD1/GRIN2C/ATP2A1/ULK1/PIK3CA/PSMD7/PSMB3 20 KEGG hsa00600 Sphingolipid metabolism 8/1001 52/8135 0.306 0.8053 0.7369 KDSR/SPTLC2/ASAH1/GBA/SMPD1/ASAH2/SMPD2/CERS4 8 KEGG hsa02010 ABC transporters 7/1001 45/8135 0.3143 0.8149 0.7456 ABCA7/ABCC10/ABCD3/ABCG4/ABCB6/ABCA6/ABCA1 7 KEGG hsa00564 Glycerophospholipid metabolism 14/1001 98/8135 0.317 0.8149 0.7456 ETNK1/AGPAT1/MBOAT7/GPAT2/PEMT/ETNK2/LPIN2/GPD1/DGKA/LPCAT4/DGKD/PLA2G4B/CDIPT/PTDSS2 14 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 14/1001 98/8135 0.317 0.8149 0.7456 PLCG1/TRPV3/TRPV2/PTGER4/PRKCQ/PIK3R2/CALM3/CYP2J2/IL1B/CALML4/CAMK2D/PTGER2/PIK3CA/PLA2G4B 14 KEGG hsa04670 Leukocyte transendothelial migration 16/1001 114/8135 0.3259 0.8311 0.7605 CLDN15/MYL5/RAC2/ESAM/VAV1/PLCG1/F11R/JAM3/PIK3R2/CD99/CXCR4/MYL12A/ACTG1/PIK3CA/ITK/MMP9 16 KEGG hsa04530 Tight junction 23/1001 169/8135 0.3347 0.842 0.7704 CDK4/CLDN15/WHAMM/ARHGEF2/F11R/PRKCI/JAM3/ARHGAP17/PARD6G/PRKAG2/ARPC1B/PARD6A/RAPGEF2/JUN/MYL12A/ACTG1/ARPC5/ACTR3/TUBA1A/ERBB2/PARD6B/PPP2R2A/RAB13 23 KEGG hsa04922 Glucagon signaling pathway 15/1001 107/8135 0.3352 0.842 0.7704 PDHA1/ATF4/PGAM4/PRMT1/SIK1/PRKAG2/PFKP/CALM3/CREB3L3/SLC2A1/ACACB/CALML4/CAMK2D/PPP3R2/CPT1C 15 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/1001 24/8135 0.3412 0.8468 0.7749 B4GALT7/GLCE/NDST2/EXT2 4 KEGG hsa00120 Primary bile acid biosynthesis 3/1001 17/8135 0.3495 0.8468 0.7749 HSD17B4/HSD3B7/AMACR 3 KEGG hsa00910 Nitrogen metabolism 3/1001 17/8135 0.3495 0.8468 0.7749 CA4/CA5B/CA13 3 KEGG hsa05224 Breast cancer 20/1001 147/8135 0.3504 0.8468 0.7749 CDK4/FZD6/RPS6KB2/GADD45A/MAP2K1/WNT10A/PIK3R2/JAG2/JUN/SOS1/FOS/CDKN1A/DDB2/ARAF/SP1/MYC/FLT4/PIK3CA/ERBB2/FZD3 20 KEGG hsa00920 Sulfur metabolism 2/1001 10/8135 0.3536 0.8468 0.7749 BPNT1/ETHE1 2 KEGG hsa05010 Alzheimer disease 50/1001 384/8135 0.3543 0.8468 0.7749 NRBF2/CASP9/CDK5/ATG14/APH1B/ATF4/FZD6/NDUFA7/SLC39A14/PPID/NDUFS7/PSMA5/SLC25A4/MAP2K1/WNT10A/BID/PIK3R2/TRAF2/KLC1/CALM3/IKBKB/DDIT3/PPIF/PSMC6/SLC39A10/SLC11A2/IL1B/NDUFA8/ATG2A/ARAF/CALML4/KLC2/PSMD1/NDUFB5/GRIN2C/TUBB1/ATP2A1/PPP3R2/ULK1/PIK3CA/PSMD7/CASP7/TUBA1A/APAF1/UQCRFS1/SLC39A1/PSMB3/FZD3/NDUFA12/NCSTN 50 KEGG hsa00514 Other types of O-glycan biosynthesis 7/1001 47/8135 0.3562 0.8468 0.7749 ST6GAL1/POGLUT1/C1GALT1C1/ST3GAL3/OGT/GALNT2/GALNT7 7 KEGG hsa04136 Autophagy - other 5/1001 32/8135 0.3578 0.8468 0.7749 ATG2A/ATG4D/GABARAPL1/ATG4C/ATG10 5 KEGG hsa04360 Axon guidance 24/1001 182/8135 0.3906 0.9151 0.8374 MYL5/CDK5/RAC2/RND1/PLCG1/EFNB1/ILK/PARD6G/SEMA4F/PIK3R2/PARD6A/FYN/CXCR4/MYL12A/PLXNA1/PLXNA4/CAMK2D/PPP3R2/PIK3CA/PARD6B/SEMA4C/FZD3/RYK/PLXNA3 24 KEGG hsa04216 Ferroptosis 6/1001 41/8135 0.3922 0.9151 0.8374 SLC3A2/SLC39A14/SLC11A2/SAT2/SLC40A1/PCBP1 6 KEGG hsa05321 Inflammatory bowel disease 9/1001 65/8135 0.4069 0.9428 0.8627 STAT6/IL13/RORA/HLA-DMB/IL2RG/IL4R/JUN/IL1B/IL23R 9 KEGG hsa05332 Graft-versus-host disease 6/1001 42/8135 0.4153 0.9554 0.8743 HLA-G/HLA-A/HLA-DMB/IL1B/HLA-B/CD80 6 KEGG hsa00510 N-Glycan biosynthesis 7/1001 50/8135 0.4196 0.9587 0.8773 ST6GAL1/DPM2/ALG13/MAN1C1/DPAGT1/ALG8/TUSC3 7 KEGG hsa00062 Fatty acid elongation 4/1001 27/8135 0.4292 0.9671 0.885 ACOT2/HADHB/ECHS1/ELOVL7 4 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 4/1001 27/8135 0.4292 0.9671 0.885 ACOT2/HSD17B4/ELOVL7/FADS2 4 KEGG hsa04915 Estrogen signaling pathway 18/1001 138/8135 0.4337 0.9707 0.8883 FKBP4/HSPA1L/HSPA1A/ATF4/RARA/MAP2K1/PIK3R2/CALM3/JUN/HSPA8/SOS1/CREB3L3/FOS/TGFA/CALML4/SP1/PIK3CA/MMP9 18 KEGG hsa04720 Long-term potentiation 9/1001 67/8135 0.4437 0.9863 0.9025 ATF4/RPS6KA1/MAP2K1/CALM3/ARAF/CALML4/GRIN2C/CAMK2D/PPP3R2 9 KEGG hsa00512 Mucin type O-glycan biosynthesis 5/1001 36/8135 0.46 1 0.9151 ST3GAL2/ST6GALNAC4/C1GALT1C1/GALNT2/GALNT7 5 KEGG hsa05226 Gastric cancer 19/1001 149/8135 0.4712 1 0.9151 RXRB/FZD6/RPS6KB2/GADD45A/CDK2/MAP2K1/WNT10A/PIK3R2/CDKN2B/SOS1/CDKN1B/CDKN1A/DDB2/JUP/ARAF/MYC/PIK3CA/ERBB2/FZD3 19 KEGG hsa00561 Glycerolipid metabolism 8/1001 61/8135 0.4813 1 0.9151 AGPAT1/GPAT2/LPIN2/ALDH7A1/LIPC/DGKA/DGKD/AGK 8 KEGG hsa05320 Autoimmune thyroid disease 7/1001 53/8135 0.4824 1 0.9151 HLA-G/HLA-A/HLA-DMB/IFNA16/HLA-B/CD80/TSHR 7 KEGG hsa04120 Ubiquitin mediated proteolysis 18/1001 142/8135 0.4847 1 0.9151 DDB1/ANAPC7/HERC4/RNF7/UBE2J2/SKP2/SOCS3/FBXW8/UBE2L6/AIRE/CUL7/UBE2Z/DDB2/UBOX5/UBA1/UBA3/UBE2D4/PIAS4 18 KEGG hsa04744 Phototransduction 4/1001 29/8135 0.4862 1 0.9151 CALM3/RCVRN/SLC24A1/CALML4 4 KEGG hsa05020 Prion disease 34/1001 273/8135 0.4981 1 0.9151 STIP1/CASP9/HSPA1L/HSPA1A/RAC2/ATF4/NDUFA7/NDUFS7/PSMA5/SLC25A4/PIK3R2/FYN/KLC1/DDIT3/PPIF/HSPA8/PSMC6/CREB3L3/IL1B/NDUFA8/KLC2/PSMD1/NDUFB5/GRIN2C/TUBB1/PPP3R2/PIK3CA/PSMD7/HSPA5/TUBA1A/APAF1/UQCRFS1/PSMB3/NDUFA12 34 KEGG hsa04917 Prolactin signaling pathway 9/1001 70/8135 0.4982 1 0.9151 CISH/SOCS3/MAP2K1/PIK3R2/SOS1/FOS/IRF1/SOCS4/PIK3CA 9 KEGG hsa04071 Sphingolipid signaling pathway 15/1001 119/8135 0.5022 1 0.9151 RAC2/SPTLC2/MAP2K1/ASAH1/BID/PIK3R2/TRAF2/FYN/SMPD1/ASAH2/GAB2/SMPD2/PIK3CA/CERS4/PPP2R2A 15 KEGG hsa05165 Human papillomavirus infection 41/1001 331/8135 0.5077 1 0.9151 CDK4/HLA-G/IKBKE/FZD6/CHD4/HDAC2/ITGA10/RPS6KB2/ITGA3/PRKCI/CDK2/PARD6G/MAP2K1/WNT10A/PTGER4/TSC1/HLA-A/COL6A2/PIK3R2/VTN/ISG15/PARD6A/IKBKB/COL1A1/NFX1/SOS1/CREB3L3/CDKN1B/ATP6V0E1/TRAF3/IRF1/CDKN1A/CCND3/IFNA16/HDAC1/HLA-B/PIK3CA/TUBG2/PARD6B/PPP2R2A/FZD3 41 KEGG hsa05330 Allograft rejection 5/1001 38/8135 0.5094 1 0.9151 HLA-G/HLA-A/HLA-DMB/HLA-B/CD80 5 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 10/1001 79/8135 0.5132 1 0.9151 PLCG1/RPS6KB2/BCL2L1/MAP2K1/PIK3R2/SOS1/TGFA/ARAF/PIK3CA/ERBB2 10 KEGG hsa04520 Adherens junction 9/1001 71/8135 0.5161 1 0.9151 PTPN6/RAC2/MAP3K7/YES1/BAIAP2/FYN/PTPN1/ACTG1/ERBB2 9 KEGG hsa05145 Toxoplasmosis 14/1001 112/8135 0.5183 1 0.9151 CASP9/HSPA1L/HSPA1A/NFKBIA/MAP3K7/BCL2L1/ALOX5/IKBKB/PPIF/HLA-DMB/HSPA8/NFKBIB/PIK3R5/IL10RB 14 KEGG hsa00620 Pyruvate metabolism 6/1001 47/8135 0.5278 1 0.9151 PDHA1/ACYP1/ACSS1/ALDH7A1/ACACB/HAGH 6 KEGG hsa04973 Carbohydrate digestion and absorption 6/1001 47/8135 0.5278 1 0.9151 HK1/PIK3R2/HK2/MGAM/PIK3CA/HKDC1 6 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/1001 14/8135 0.5285 1 0.9151 ST3GAL2/ST3GAL3 2 KEGG hsa04141 Protein processing in endoplasmic reticulum 21/1001 171/8135 0.5395 1 0.9151 HSPA1L/HSPA1A/ATF4/UBE2J2/UBXN6/DNAJA1/NGLY1/TRAF2/MAN1C1/UBQLN4/DDIT3/PPP1R15A/HSPA8/YOD1/SEC61A2/OS9/DERL2/HSPA5/TUSC3/RNF5/UBE2D4 21 KEGG hsa00410 beta-Alanine metabolism 4/1001 31/8135 0.5407 1 0.9151 ALDH7A1/ECHS1/SMOX/CNDP1 4 KEGG hsa04710 Circadian rhythm 4/1001 31/8135 0.5407 1 0.9151 PER1/CRY2/PRKAG2/RORA 4 KEGG hsa05310 Asthma 4/1001 31/8135 0.5407 1 0.9151 IL13/HLA-DMB/PRG2/IL3 4 KEGG hsa00280 Valine, leucine and isoleucine degradation 6/1001 48/8135 0.5493 1 0.9151 HADHB/ALDH7A1/ECHS1/MCCC1/HMGCL/ACAD8 6 KEGG hsa03060 Protein export 3/1001 23/8135 0.5509 1 0.9151 SEC61A2/SPCS2/HSPA5 3 KEGG hsa04072 Phospholipase D signaling pathway 18/1001 148/8135 0.5594 1 0.9151 LPAR3/AGPAT1/PLCG1/RALB/MAP2K1/TSC1/PIK3R2/FYN/SOS1/DGKA/PIK3R5/CYTH2/GAB2/DGKD/PIK3CA/PLA2G4B/DNM2/LPAR2 18 KEGG hsa04151 PI3K-Akt signaling pathway 43/1001 354/8135 0.5622 1 0.9151 CDK4/CASP9/LPAR3/ATF4/ITGA10/AREG/RPS6KB2/MTCP1/BCL2L1/ITGA3/CDK2/MAP2K1/OSM/YWHAE/TSC1/COL6A2/PIK3R2/VTN/DDIT4/IKBKB/COL1A1/IL2RG/IL4R/SOS1/CREB3L3/CDKN1B/CDKN1A/TGFA/PIK3R5/CCND3/IFNA16/NGFR/MYC/FLT4/GNG8/PIK3CA/ERBB2/IL3/PKN3/GH1/PPP2R2A/GNG4/LPAR2 43 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 2/1001 15/8135 0.567 1 0.9151 ST3GAL2/NAGA 2 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/1001 15/8135 0.567 1 0.9151 ST3GAL2/ST6GALNAC4 2 KEGG hsa05030 Cocaine addiction 6/1001 49/8135 0.5704 1 0.9151 CDK5/ATF4/JUN/CREB3L3/FOSB/GRIN2C 6 KEGG hsa00480 Glutathione metabolism 7/1001 58/8135 0.582 1 0.9151 ODC1/GSTM1/GSTA4/GSTM4/GPX1/GSTT1/GSR 7 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 12/1001 100/8135 0.5833 1 0.9151 IL34/TNFSF10/TNFRSF10B/CXCR4/IL20RB/IL2RG/CXCL5/IL10RB/TNFRSF10D/LTA/PPBP/PF4V1 12 KEGG hsa04130 SNARE interactions in vesicular transport 4/1001 33/8135 0.5921 1 0.9151 SNAP23/GOSR2/SEC22B/BNIP1 4 KEGG hsa03008 Ribosome biogenesis in eukaryotes 13/1001 109/8135 0.5924 1 0.9151 RPP40/NOP10/REXO2/GNL3/UTP15/TBL3/POP1/NAT10/WDR43/NOP56/EIF6/REXO1/NXT1 13 KEGG hsa04015 Rap1 signaling pathway 25/1001 210/8135 0.6032 1 0.9151 ADORA2A/RGS14/RAC2/ID1/LPAR3/EVL/VAV1/PLCG1/RAP1GAP/RALB/PRKCI/PARD6G/MAP2K1/PIK3R2/PARD6A/RAPGEF2/CALM3/CRK/ACTG1/CALML4/NGFR/FLT4/PIK3CA/PARD6B/LPAR2 25 KEGG hsa00430 Taurine and hypotaurine metabolism 2/1001 16/8135 0.6032 1 0.9151 ADO/FMO4 2 KEGG hsa05100 Bacterial invasion of epithelial cells 9/1001 77/8135 0.618 1 0.9151 ILK/ARPC1B/PIK3R2/CRK/ACTG1/ARPC5/PIK3CA/ACTR3/DNM2 9 KEGG hsa05140 Leishmaniasis 9/1001 77/8135 0.618 1 0.9151 PTPN6/NFKBIA/CR1/MAP3K7/HLA-DMB/JUN/IL1B/NFKBIB/FOS 9 KEGG hsa04612 Antigen processing and presentation 9/1001 78/8135 0.6339 1 0.9151 HSPA1L/HSPA1A/HLA-G/HLA-A/HLA-DMB/HSPA8/HLA-B/IFI30/HSPA5 9 KEGG hsa00790 Folate biosynthesis 3/1001 26/8135 0.6368 1 0.9151 MOCS1/GCH1/PTS 3 KEGG hsa00590 Arachidonic acid metabolism 7/1001 61/8135 0.637 1 0.9151 CYP2U1/ALOX5/CBR3/CYP2J2/PTGES3/GPX1/PLA2G4B 7 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 8/1001 70/8135 0.6434 1 0.9151 NFKBIA/CSK/PLCG1/F11R/JAM3/IKBKB/JUN/ATP6V0E1 8 KEGG hsa04962 Vasopressin-regulated water reabsorption 5/1001 44/8135 0.6444 1 0.9151 DYNLL1/DCTN4/CREB3L3/DYNC1LI2/DCTN6 5 KEGG hsa04390 Hippo signaling pathway 18/1001 157/8135 0.6634 1 0.9151 ID1/FZD6/AREG/PRKCI/PARD6G/YWHAE/WNT10A/AJUBA/PARD6A/BMP6/ACTG1/BBC3/LATS2/CCND3/MYC/PARD6B/PPP2R2A/FZD3 18 KEGG hsa00511 Other glycan degradation 2/1001 18/8135 0.6686 1 0.9151 MAN2C1/GBA 2 KEGG hsa04211 Longevity regulating pathway 10/1001 89/8135 0.6695 1 0.9151 EHMT2/ATF4/RPS6KB2/PRKAG2/TSC1/PIK3R2/ADIPOR2/CREB3L3/ULK1/PIK3CA 10 KEGG hsa05217 Basal cell carcinoma 7/1001 63/8135 0.6713 1 0.9151 FZD6/GADD45A/WNT10A/CDKN1A/DDB2/GLI3/FZD3 7 KEGG hsa04137 Mitophagy - animal 8/1001 72/8135 0.6752 1 0.9151 ATF4/TAX1BP1/BNIP3/BCL2L1/JUN/GABARAPL1/SP1/ULK1 8 KEGG hsa05218 Melanoma 8/1001 72/8135 0.6752 1 0.9151 CDK4/GADD45A/MAP2K1/PIK3R2/CDKN1A/DDB2/ARAF/PIK3CA 8 KEGG hsa03050 Proteasome 5/1001 46/8135 0.6839 1 0.9151 PSMA5/PSMC6/PSMD1/PSMD7/PSMB3 5 KEGG hsa05143 African trypanosomiasis 4/1001 37/8135 0.684 1 0.9151 HBA2/HBB/APOL1/IL1B 4 KEGG hsa00650 Butanoate metabolism 3/1001 28/8135 0.6873 1 0.9151 BDH1/ECHS1/HMGCL 3 KEGG hsa05415 Diabetic cardiomyopathy 23/1001 203/8135 0.6976 1 0.9151 PDHA1/RAC2/NDUFA7/NDUFS7/SLC25A4/CPT2/GFPT2/PIK3R2/PPIF/COL1A1/NDUFA8/PARP1/SLC2A1/PDK2/SP1/NDUFB5/CAMK2D/ATP2A1/PIK3CA/MMP9/UQCRFS1/GSR/NDUFA12 23 KEGG hsa00531 Glycosaminoglycan degradation 2/1001 19/8135 0.6978 1 0.9151 HYAL3/HYAL2 2 KEGG hsa04392 Hippo signaling pathway - multiple species 3/1001 29/8135 0.7105 1 0.9151 RASSF2/AJUBA/LATS2 3 KEGG hsa01240 Biosynthesis of cofactors 17/1001 153/8135 0.7114 1 0.9151 VKORC1/VKORC1L1/UGDH/MAT2A/RDH11/GGCX/MOCS1/GCH1/MAT2B/NMNAT1/OXSM/PSAT1/LIPT1/MTHFD2L/PTS/ALAS1/MTHFD1 17 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 25/1001 223/8135 0.723 1 0.9151 SLC26A6/NFKBIA/NDUFA7/NDUFS7/AKR1C2/SLC25A4/MAP2K1/PIK3R2/IKBKB/PPIF/JUN/PTPN1/SOS1/EPHX1/GSTM1/NDUFA8/FOS/ARAF/NDUFB5/PIK3CA/GSTA4/GSTM4/UQCRFS1/GSTT1/NDUFA12 25 KEGG hsa04912 GnRH signaling pathway 10/1001 93/8135 0.7231 1 0.9151 ATF4/MAP2K1/CALM3/JUN/GNRH1/SOS1/MAP3K3/CALML4/CAMK2D/PLA2G4B 10 KEGG hsa00513 Various types of N-glycan biosynthesis 4/1001 39/8135 0.7241 1 0.9151 ALG13/ST3GAL3/MAN1C1/TUSC3 4 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2/1001 20/8135 0.7249 1 0.9151 B4GALT7/CHPF2 2 KEGG hsa01523 Antifolate resistance 3/1001 30/8135 0.7324 1 0.9151 GART/IKBKB/IL1B 3 KEGG hsa04926 Relaxin signaling pathway 14/1001 129/8135 0.7328 1 0.9151 NFKBIA/ATF4/MAP2K1/PIK3R2/COL1A1/JUN/SOS1/CREB3L3/FOS/RXFP4/GNG8/PIK3CA/MMP9/GNG4 14 KEGG hsa01232 Nucleotide metabolism 9/1001 85/8135 0.7343 1 0.9151 AMPD2/NTPCR/NT5E/DTYMK/AMPD3/GMPR2/ASMTL/NT5M/PNP 9 KEGG hsa04350 TGF-beta signaling pathway 10/1001 94/8135 0.7355 1 0.9151 ID1/RPS6KB2/TGIF1/BMP6/INHBC/CDKN2B/ID3/AMHR2/SP1/MYC 10 KEGG hsa04725 Cholinergic synapse 12/1001 113/8135 0.75 1 0.9151 ATF4/MAP2K1/CHRM4/PIK3R2/FYN/CREB3L3/FOS/PIK3R5/CAMK2D/GNG8/PIK3CA/GNG4 12 KEGG hsa04062 Chemokine signaling pathway 21/1001 192/8135 0.752 1 0.9151 RAC2/GSK3A/NFKBIA/VAV1/PLCG1/GRK6/MAP2K1/PIK3R2/CXCR4/IKBKB/CRK/SOS1/CXCL5/NFKBIB/PIK3R5/GNG8/PIK3CA/PPBP/ITK/PF4V1/GNG4 21 KEGG hsa04810 Regulation of actin cytoskeleton 24/1001 218/8135 0.7523 1 0.9151 MYL5/RAC2/VAV1/ITGA10/ITGA3/MAP2K1/ARPC1B/CHRM4/BAIAP2/PIK3R2/CXCR4/ABI2/CYFIP1/CRK/MYL12A/SOS1/ACTG1/ARPC5/ARAF/PIK3CA/ACTR3/CYFIP2/PIP4K2B/LPAR2 24 KEGG hsa04510 Focal adhesion 22/1001 201/8135 0.7548 1 0.9151 MYL5/RAC2/VAV1/ITGA10/ITGA3/ILK/MAP2K1/COL6A2/PIK3R2/VTN/FYN/COL1A1/JUN/CRK/MYL12A/SOS1/ACTG1/CCND3/ZYX/FLT4/PIK3CA/ERBB2 22 KEGG hsa04924 Renin secretion 7/1001 69/8135 0.7614 1 0.9151 EDN2/PTGER4/EDN3/CALM3/CALML4/PTGER2/PPP3R2 7 KEGG hsa04310 Wnt signaling pathway 18/1001 167/8135 0.7618 1 0.9151 RAC2/FZD6/MAP3K7/CBY1/WNT10A/PRICKLE3/JUN/TLE3/ROR2/CCND3/NOTUM/MYC/PRICKLE4/CAMK2D/PPP3R2/LGR4/FZD3/RYK 18 KEGG hsa04913 Ovarian steroidogenesis 5/1001 51/8135 0.7691 1 0.9151 ACOT2/ALOX5/BMP6/CYP2J2/PLA2G4B 5 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 11/1001 106/8135 0.7707 1 0.9151 JUND/NR4A2/ATF4/RXRB/MAP2K1/MEF2D/CREB3L3/FOS/CDKN1A/ARAF/SP1 11 KEGG hsa00640 Propanoate metabolism 3/1001 32/8135 0.7722 1 0.9151 ACSS1/ECHS1/ACACB 3 KEGG hsa00220 Arginine biosynthesis 2/1001 22/8135 0.773 1 0.9151 GLS/ASS1 2 KEGG hsa04936 Alcoholic liver disease 15/1001 142/8135 0.7743 1 0.9151 NFKBIA/IKBKE/MAP3K7/C4B/PRKAG2/LPIN2/ALDH7A1/IL17RA/IKBKB/ADIPOR2/IL1B/TRAF3/IFNA16/ACACB/CPT1C 15 KEGG hsa04024 cAMP signaling pathway 24/1001 221/8135 0.7754 1 0.9151 ADORA2A/EDN2/RAC2/NFKBIA/LIPE/VAV1/MAP2K1/PIK3R2/EDN3/CALM3/HCAR3/JUN/CREB3L3/FOS/CALML4/GRIN2C/CAMK2D/ATP2A1/PTGER2/PIK3CA/GPR119/GLI3/HCAR1/TSHR 24 KEGG hsa00380 Tryptophan metabolism 4/1001 42/8135 0.777 1 0.9151 GCDH/ALDH8A1/ALDH7A1/ECHS1 4 KEGG hsa00515 Mannose type O-glycan biosynthesis 2/1001 23/8135 0.7941 1 0.9151 ST3GAL3/FKTN 2 KEGG hsa04614 Renin-angiotensin system 2/1001 23/8135 0.7941 1 0.9151 CTSA/NLN 2 KEGG hsa04964 Proximal tubule bicarbonate reclamation 2/1001 23/8135 0.7941 1 0.9151 GLS/CA4 2 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 10/1001 100/8135 0.8023 1 0.9151 PIM1/CDK4/PLCG1/PIK3R2/COL1A1/JUN/PLCD1/CDKN1B/IL1B/PIK3CA 10 KEGG hsa00310 Lysine degradation 6/1001 63/8135 0.804 1 0.9151 EHMT2/GCDH/ALDH7A1/ECHS1/TMLHE/ASH1L 6 KEGG hsa00040 Pentose and glucuronate interconversions 3/1001 34/8135 0.807 1 0.9151 UGDH/RPE/XYLB 3 KEGG hsa00230 Purine metabolism 13/1001 128/8135 0.8091 1 0.9151 AMPD2/GART/NUDT9/NTPCR/NT5E/AMPD3/GMPR2/NUDT5/NT5M/PNP/PGM2/PRPS1L1/PDE6H 13 KEGG hsa04935 Growth hormone synthesis, secretion and action 12/1001 119/8135 0.8096 1 0.9151 ATF4/PLCG1/SOCS3/JUNB/MAP2K1/PIK3R2/CRK/SOS1/CREB3L3/FOS/PIK3CA/GH1 12 KEGG hsa04914 Progesterone-mediated oocyte maturation 10/1001 102/8135 0.8215 1 0.9151 ANAPC7/CDC25B/RPS6KA1/CDK2/MAP2K1/PIK3R2/AURKA/ARAF/PIK3CA/CPEB1 10 KEGG hsa00592 alpha-Linolenic acid metabolism 2/1001 25/8135 0.8312 1 0.9151 FADS2/PLA2G4B 2 KEGG hsa03320 PPAR signaling pathway 7/1001 75/8135 0.8321 1 0.9151 RXRB/SLC27A4/ILK/CPT2/CPT1C/FADS2/PLIN5 7 KEGG hsa04114 Oocyte meiosis 13/1001 131/8135 0.8339 1 0.9151 ANAPC7/RPS6KA1/CDK2/MAP2K1/YWHAE/AURKA/CALM3/REC8/SMC3/CALML4/CAMK2D/PPP3R2/CPEB1 13 KEGG hsa05207 Chemical carcinogenesis - receptor activation 22/1001 212/8135 0.8342 1 0.9151 IKBKE/ATF4/RXRB/BCL6/RPS6KA1/RPS6KB2/KPNA5/MAP2K1/PIK3R2/JUN/SOS1/EPHX1/CREB3L3/GSTM1/FOS/CCND3/MYC/PTGES3/PIK3CA/GSTA4/GSTM4/GSTT1 22 KEGG hsa04610 Complement and coagulation cascades 8/1001 85/8135 0.8372 1 0.9151 CD46/CR1/CD55/C4B/VTN/KLKB1/PROS1/TFPI 8 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 3/1001 37/8135 0.8507 1 0.9151 GLS/GFPT2/ASS1 3 KEGG hsa04611 Platelet activation 12/1001 124/8135 0.8508 1 0.9151 PTGIR/PRKCI/PIK3R2/FYN/COL1A1/FERMT3/MYL12A/ACTG1/SNAP23/PIK3R5/PIK3CA/PLA2G4B 12 KEGG hsa03015 mRNA surveillance pathway 9/1001 97/8135 0.8592 1 0.9151 DDX19B/DDX39B/CLP1/GLE1/PCF11/PELO/NXT1/PPP2R2A/CPSF7 9 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 7/1001 78/8135 0.8607 1 0.9151 AKR7A3/CBR3/EPHX1/GSTM1/GSTA4/GSTM4/GSTT1 7 KEGG hsa00730 Thiamine metabolism 1/1001 15/8135 0.8607 1 0.9151 NTPCR 1 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 2/1001 27/8135 0.8622 1 0.9151 ST3GAL3/ABO 2 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 6/1001 69/8135 0.8677 1 0.9151 AKR1C2/EPHX1/GSTM1/GSTA4/GSTM4/GSTT1 6 KEGG hsa00565 Ether lipid metabolism 4/1001 49/8135 0.8692 1 0.9151 GDPD3/PAFAH1B3/LPCAT4/PLA2G4B 4 KEGG hsa04934 Cushing syndrome 15/1001 155/8135 0.8728 1 0.9151 CDK4/NCEH1/MEN1/ATF4/FZD6/CDK2/MAP2K1/WNT10A/CDKN2B/CREB3L3/CDKN1B/CDKN1A/SP1/CAMK2D/FZD3 15 KEGG hsa04640 Hematopoietic cell lineage 9/1001 99/8135 0.8746 1 0.9151 CR1/CD55/ITGA3/CD9/HLA-DMB/IL4R/IL1B/IL3/CD7 9 KEGG hsa04978 Mineral absorption 5/1001 60/8135 0.8767 1 0.9151 SLC26A6/HMOX2/SLC11A2/SLC40A1/SLC30A1 5 KEGG hsa04979 Cholesterol metabolism 4/1001 50/8135 0.8792 1 0.9151 NCEH1/LDLRAP1/LIPC/ABCA1 4 KEGG hsa05110 Vibrio cholerae infection 4/1001 50/8135 0.8792 1 0.9151 PLCG1/ACTG1/ATP6V0E1/SEC61A2 4 KEGG hsa05144 Malaria 4/1001 50/8135 0.8792 1 0.9151 CR1/HBA2/HBB/IL1B 4 KEGG hsa00591 Linoleic acid metabolism 2/1001 29/8135 0.8879 1 0.9151 CYP2J2/PLA2G4B 2 KEGG hsa00270 Cysteine and methionine metabolism 4/1001 51/8135 0.8886 1 0.9151 MAT2A/APIP/MAT2B/PSAT1 4 KEGG hsa04060 Cytokine-cytokine receptor interaction 30/1001 295/8135 0.8925 1 0.9151 IL34/CD27/IL27RA/TNFSF10/TNFRSF10B/IL13/OSM/CXCR4/IL20RB/BMP6/IL17RA/INHBC/GDF11/IL2RG/IL4R/CXCL5/IL1B/AMHR2/TNFRSF6B/IFNA16/IL17C/IL10RB/TNFRSF10D/NGFR/LTA/PPBP/IL3/GH1/PF4V1/IL23R 30 KEGG hsa04714 Thermogenesis 23/1001 232/8135 0.8926 1 0.9151 SMARCB1/COA5/NDUFAF1/ACTL6A/LIPE/COA3/RPS6KA1/RPS6KB2/NDUFA7/NDUFS7/CPT2/PRKAG2/TSC1/COX19/SOS1/CREB3L3/ACTG1/NDUFA8/NDUFB5/ARID1B/CPT1C/UQCRFS1/NDUFA12 23 KEGG hsa05205 Proteoglycans in cancer 20/1001 205/8135 0.8942 1 0.9151 PTPN6/FZD6/VAV1/PLCG1/RPS6KB2/MAP2K1/WNT10A/PIK3R2/VTN/COL1A1/SOS1/ACTG1/CDKN1A/ARAF/MYC/CAMK2D/PIK3CA/ERBB2/MMP9/FZD3 20 KEGG hsa05142 Chagas disease 9/1001 102/8135 0.895 1 0.9151 NFKBIA/CFLAR/PIK3R2/IKBKB/JUN/IL1B/FOS/PIK3CA/PPP2R2A 9 KEGG hsa00053 Ascorbate and aldarate metabolism 2/1001 30/8135 0.899 1 0.9151 UGDH/ALDH7A1 2 KEGG hsa05323 Rheumatoid arthritis 8/1001 93/8135 0.9 1 0.9151 HLA-DMB/JUN/CXCL5/IL1B/ATP6V0E1/FOS/ACP5/CD80 8 KEGG hsa05152 Tuberculosis 17/1001 180/8135 0.9064 1 0.9151 CASP9/CASP10/CR1/CORO1A/BID/CALM3/HSPD1/HLA-DMB/TLR1/IL1B/IFNA16/CALML4/IL10RB/CAMK2D/PPP3R2/APAF1/IRAK2 17 KEGG hsa04975 Fat digestion and absorption 3/1001 43/8135 0.913 1 0.9151 AGPAT1/SLC27A4/ABCA1 3 KEGG hsa04918 Thyroid hormone synthesis 6/1001 75/8135 0.9131 1 0.9151 ATF4/CREB3L3/HSPA5/GPX1/GSR/TSHR 6 KEGG hsa04713 Circadian entrainment 8/1001 97/8135 0.9228 1 0.9151 PER1/CALM3/FOS/CALML4/GRIN2C/CAMK2D/GNG8/GNG4 8 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 6/1001 77/8135 0.9249 1 0.9151 ITGA10/ITGA3/ACTG1/ACTN3/JUP/ATP2A1 6 KEGG hsa04923 Regulation of lipolysis in adipocytes 4/1001 56/8135 0.9265 1 0.9151 LIPE/PIK3R2/PIK3CA/TSHR 4 KEGG hsa04014 Ras signaling pathway 22/1001 232/8135 0.9277 1 0.9151 RAC2/PLCG1/SYNGAP1/RALB/BCL2L1/EXOC2/MAP2K1/PIK3R2/CALM3/IKBKB/SOS1/RALBP1/TGFA/CALML4/REL/GAB2/NGFR/FLT4/GNG8/PIK3CA/PLA2G4B/GNG4 22 KEGG hsa05171 Coronavirus disease - COVID-19 22/1001 232/8135 0.9277 1 0.9151 OAS2/DDX58/RPS4Y1/NFKBIA/IKBKE/PLCG1/MAP3K7/CASP1/C4B/PIK3R2/ISG15/IKBKB/OAS1/JUN/NLRP3/IL1B/TRAF3/NFKBIB/FOS/IFNA16/PIK3CA/RPS7 22 KEGG hsa00100 Steroid biosynthesis 1/1001 20/8135 0.9279 1 0.9151 LBR 1 KEGG hsa04514 Cell adhesion molecules 13/1001 149/8135 0.9347 1 0.9151 CLDN15/ICAM2/ESAM/HLA-G/F11R/NLGN3/JAM3/HLA-A/CD99/HLA-DMB/HLA-B/CDH3/CD80 13 KEGG hsa00240 Pyrimidine metabolism 4/1001 58/8135 0.9381 1 0.9151 NT5E/DTYMK/ASMTL/NT5M 4 KEGG hsa04916 Melanogenesis 8/1001 101/8135 0.941 1 0.9151 FZD6/MAP2K1/WNT10A/CALM3/CREB3L3/CALML4/CAMK2D/FZD3 8 KEGG hsa04613 Neutrophil extracellular trap formation 17/1001 190/8135 0.9431 1 0.9151 RAC2/PLCG1/CR1/HDAC2/MAP3K7/HDAC7/CASP1/AZU1/SLC25A4/MAP2K1/PIK3R2/PPIF/ACTG1/HDAC1/PIK3CA/GSDMD/CLCN3 17 KEGG hsa04145 Phagosome 13/1001 152/8135 0.945 1 0.9151 M6PR/HLA-G/CORO1A/HLA-A/HLA-DMB/ACTG1/ATP6V0E1/DYNC1LI2/HLA-B/SEC61A2/SEC22B/TUBB1/TUBA1A 13 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 12/1001 143/8135 0.9476 1 0.9151 ID1/FZD6/MAP2K1/WNT10A/PIK3R2/INHBC/TCF3/ID3/MYC/PCGF3/PIK3CA/FZD3 12 KEGG hsa04672 Intestinal immune network for IgA production 3/1001 49/8135 0.9506 1 0.9151 CXCR4/HLA-DMB/CD80 3 KEGG hsa04921 Oxytocin signaling pathway 13/1001 154/8135 0.951 1 0.9151 MAP2K1/PRKAG2/CALM3/JUN/ACTG1/FOS/CDKN1A/PIK3R5/CALML4/CAMK2D/PPP3R2/RCAN1/PLA2G4B 13 KEGG hsa00982 Drug metabolism - cytochrome P450 5/1001 72/8135 0.9517 1 0.9151 GSTM1/GSTA4/GSTM4/GSTT1/FMO4 5 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 2/1001 37/8135 0.9523 1 0.9151 PIK3R2/PIK3CA 2 KEGG hsa05340 Primary immunodeficiency 2/1001 38/8135 0.9572 1 0.9151 AIRE/IL2RG 2 KEGG hsa04977 Vitamin digestion and absorption 1/1001 24/8135 0.9574 1 0.9151 MMACHC 1 KEGG hsa05034 Alcoholism 16/1001 187/8135 0.9602 1 0.9151 ADORA2A/ATF4/HDAC2/HDAC7/MAP2K1/CALM3/SOS1/CREB3L3/FOSB/HDAC1/SLC29A3/ARAF/CALML4/GRIN2C/GNG8/GNG4 16 KEGG hsa04929 GnRH secretion 4/1001 64/8135 0.9636 1 0.9151 MAP2K1/PIK3R2/GNRH1/PIK3CA 4 KEGG hsa04971 Gastric acid secretion 5/1001 76/8135 0.9654 1 0.9151 SLC4A2/CALM3/ACTG1/CALML4/CAMK2D 5 KEGG hsa04925 Aldosterone synthesis and secretion 7/1001 98/8135 0.9656 1 0.9151 NR4A2/LIPE/ATF4/CALM3/CREB3L3/CALML4/CAMK2D 7 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 3/1001 53/8135 0.9666 1 0.9151 AP2S1/AP2A2/DNM2 3 KEGG hsa04927 Cortisol synthesis and secretion 4/1001 65/8135 0.9668 1 0.9151 NCEH1/ATF4/CREB3L3/SP1 4 KEGG hsa04976 Bile secretion 6/1001 89/8135 0.9703 1 0.9151 NCEH1/SLC4A2/EPHX1/HMGCR/SLC4A5/SLC2A1 6 KEGG hsa04728 Dopaminergic synapse 10/1001 132/8135 0.971 1 0.9151 GSK3A/ATF4/CALM3/CREB3L3/FOS/CALML4/CAMK2D/GNG8/PPP2R2A/GNG4 10 KEGG hsa04966 Collecting duct acid secretion 1/1001 27/8135 0.9713 1 0.9151 ATP6V0E1 1 KEGG hsa04270 Vascular smooth muscle contraction 10/1001 134/8135 0.9747 1 0.9151 ADORA2A/EDN2/PTGIR/MAP2K1/PRKCQ/EDN3/CALM3/ARAF/CALML4/PLA2G4B 10 KEGG hsa00860 Porphyrin metabolism 2/1001 43/8135 0.9754 1 0.9151 HMOX2/ALAS1 2 KEGG hsa00983 Drug metabolism - other enzymes 5/1001 80/8135 0.9754 1 0.9151 CES2/GSTM1/GSTA4/GSTM4/GSTT1 5 KEGG hsa04974 Protein digestion and absorption 7/1001 103/8135 0.9766 1 0.9151 SLC3A2/CTRL/SLC3A1/COL6A2/COL1A1/SLC1A5/SLC36A1 7 KEGG hsa04022 cGMP-PKG signaling pathway 13/1001 167/8135 0.9779 1 0.9151 ATF4/SRF/SLC25A4/MAP2K1/MEF2D/CALM3/PPIF/CREB3L3/PIK3R5/GTF2I/CALML4/ATP2A1/PPP3R2 13 KEGG hsa04726 Serotonergic synapse 8/1001 115/8135 0.9785 1 0.9151 DUSP1/MAP2K1/ALOX5/CYP2J2/ARAF/GNG8/PLA2G4B/GNG4 8 KEGG hsa00020 Citrate cycle (TCA cycle) 1/1001 30/8135 0.9807 1 0.9151 PDHA1 1 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 1/1001 30/8135 0.9807 1 0.9151 ACSS1 1 KEGG hsa04371 Apelin signaling pathway 10/1001 139/8135 0.9822 1 0.9151 LIPE/RPS6KB2/MAP2K1/PRKAG2/MEF2D/CALM3/PIK3R5/CALML4/GNG8/GNG4 10 KEGG hsa04730 Long-term depression 3/1001 60/8135 0.9835 1 0.9151 MAP2K1/ARAF/PLA2G4B 3 KEGG hsa04911 Insulin secretion 5/1001 86/8135 0.9855 1 0.9151 ATF4/CREB3L3/SLC2A1/CAMK2D/GPR119 5 KEGG hsa04512 ECM-receptor interaction 5/1001 88/8135 0.9879 1 0.9151 ITGA10/ITGA3/COL6A2/VTN/COL1A1 5 KEGG hsa04727 GABAergic synapse 5/1001 89/8135 0.989 1 0.9151 GLS/GABARAPL1/GNG8/SLC38A5/GNG4 5 KEGG hsa05410 Hypertrophic cardiomyopathy 5/1001 90/8135 0.9899 1 0.9151 ITGA10/ITGA3/PRKAG2/ACTG1/ATP2A1 5 KEGG hsa04721 Synaptic vesicle cycle 4/1001 78/8135 0.9902 1 0.9151 AP2S1/ATP6V0E1/AP2A2/DNM2 4 KEGG hsa04724 Glutamatergic synapse 7/1001 114/8135 0.9904 1 0.9151 GLS/DLGAP1/GRIN2C/GNG8/PPP3R2/PLA2G4B/GNG4 7 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 3/1001 66/8135 0.9911 1 0.9151 DARS2/GATC/MTFMT 3 KEGG hsa00350 Tyrosine metabolism 1/1001 36/8135 0.9912 1 0.9151 FAHD1 1 KEGG hsa00830 Retinol metabolism 3/1001 68/8135 0.9928 1 0.9151 RDH11/DHRS4/RETSAT 3 KEGG hsa04340 Hedgehog signaling pathway 2/1001 56/8135 0.9944 1 0.9151 SPOP/GLI3 2 KEGG hsa04020 Calcium signaling pathway 18/1001 240/8135 0.9945 1 0.9151 ADORA2A/PLCG1/CYSLTR2/SLC25A4/CXCR4/CALM3/PPIF/LTB4R2/PLCD1/CALML4/FLT4/GRIN2C/P2RX4/CAMK2D/ATP2A1/PPP3R2/ERBB2/ITPKC 18 KEGG hsa05033 Nicotine addiction 1/1001 40/8135 0.9948 1 0.9151 GRIN2C 1 KEGG hsa00190 Oxidative phosphorylation 8/1001 134/8135 0.9952 1 0.9151 NDUFA7/NDUFS7/ATP6V0E1/NDUFA8/PPA1/NDUFB5/UQCRFS1/NDUFA12 8 KEGG hsa04742 Taste transduction 4/1001 86/8135 0.9956 1 0.9151 TAS2R5/TAS2R30/SCN9A/PKD2L1 4 KEGG hsa03010 Ribosome 10/1001 158/8135 0.9957 1 0.9151 MRPS5/RPS4Y1/MRPL10/MRPL32/MRPS11/MRPS6/MRPS2/MRPL18/MRPL24/RPS7 10 KEGG hsa04723 Retrograde endocannabinoid signaling 9/1001 148/8135 0.9961 1 0.9151 NAPEPLD/NDUFA7/NDUFS7/NDUFA8/NDUFB5/GNG8/ABHD6/NDUFA12/GNG4 9 KEGG hsa04540 Gap junction 4/1001 88/8135 0.9964 1 0.9151 MAP2K1/SOS1/TUBB1/TUBA1A 4 KEGG hsa04972 Pancreatic secretion 5/1001 102/8135 0.9967 1 0.9151 SLC4A2/CTRL/RAB3D/BST1/ATP2A1 5 KEGG hsa04970 Salivary secretion 4/1001 93/8135 0.9978 1 0.9151 SLC4A2/BST1/CALM3/CALML4 4 KEGG hsa05414 Dilated cardiomyopathy 4/1001 96/8135 0.9984 1 0.9151 ITGA10/ITGA3/ACTG1/ATP2A1 4 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 8/1001 150/8135 0.9988 1 0.9151 ATF4/CALM3/CREB3L3/PIK3R5/CALML4/CAMK2D/ATP2A1/PPP2R2A 8 KEGG hsa05146 Amoebiasis 4/1001 102/8135 0.9991 1 0.9151 PIK3R2/COL1A1/IL1B/PIK3CA 4 KEGG hsa05032 Morphine addiction 3/1001 91/8135 0.9994 1 0.9151 GRK6/GNG8/GNG4 3 KEGG hsa05206 MicroRNAs in cancer 21/1001 310/8135 0.9996 1 0.9151 PIM1/GLS/PLCG1/HDAC2/CDC25B/MAP2K1/PIK3R2/DDIT4/IKBKB/DICER1/CRK/SOS1/CDKN1B/CDKN1A/HDAC1/MYC/PIK3CA/VIM/ERBB2/MMP9/FZD3 21 KEGG hsa00140 Steroid hormone biosynthesis 1/1001 61/8135 0.9997 1 0.9151 AKR1C2 1 KEGG hsa04260 Cardiac muscle contraction 2/1001 87/8135 0.9999 1 0.9151 ATP2A1/UQCRFS1 2 KEGG hsa04080 Neuroactive ligand-receptor interaction 23/1001 353/8135 0.9999 1 0.9151 ADORA2A/EDN2/LPAR3/CHRNA10/PTGIR/CYSLTR2/PTGER4/NR3C1/CHRM4/EDN3/P2RY8/LTB4R2/GNRH1/PTH2R/GRIN2C/P2RX4/RXFP4/PTGER2/P2RY11/PMCH/GH1/TSHR/LPAR2 23 KEGG hsa05150 Staphylococcus aureus infection 2/1001 96/8135 1 1 0.9151 C4B/HLA-DMB 2 KEGG hsa05322 Systemic lupus erythematosus 3/1001 136/8135 1 1 0.9151 C4B/HLA-DMB/CD80 3 KEGG hsa04740 Olfactory transduction 26/1001 440/8135 1 1 0.9151 OR1M1/OR5B21/OR2L8/CALM3/OR2T3/OR2K2/OR1F1/OR1B1/OR2T2/OR5AS1/OR8B4/OR52N1/OR5P3/CALML4/OR1D2/OR52B2/CAMK2D/OR8D4/OR1L8/OR1K1/OR2T12/OR51F1/OR10C1/OR1G1/OR5C1/OR1L4 26