ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05321	Inflammatory bowel disease	37/2250	65/8135	6.252e-07	0.0001521	0.0001376	IL1B/IL18/IL21/IL10/IL17A/TNF/TLR4/FOXP3/HLA-DMA/STAT3/IL4R/IL2RG/IL12RB2/TGFB3/IL21R/RORC/HLA-DPA1/TLR2/HLA-DRA/NOD2/IL12RB1/IL18R1/JUN/STAT4/MAF/HLA-DMB/IL22/HLA-DQA2/IL13/IFNGR1/IL4/HLA-DPB1/STAT1/TGFB1/HLA-DRB1/GATA3/IL23A	37
KEGG	hsa03010	Ribosome	72/2250	158/8135	9.11e-07	0.0001521	0.0001376	RPL3/MRPL28/RPS8/RPL32/RPS25/RPS12/RPL10A/RPS18/RPS27/RPL35/RPL38/RPS10/RPS3A/RPLP2/RPL21/MRPL22/RPL19/RPL23A/RPS5/RPL36/RPL5/RPL4/RPL30/MRPL18/RPL27A/RPL26/MRPS5/RPS23/RPS6/RPS15/MRPS18C/RPL36A/MRPS11/RPL7/RPL18A/RPS13/RPS20/RPL6/RPS3/RPS15A/RPS27A/MRPS6/FAU/RPL23/RPS11/RPS19/UBA52/RPS16/MRPL20/RPS9/RPL14/RPL37A/MRPL36/MRPS2/RPL37/MRPL35/MRPL27/MRPL15/RPL29/MRPL34/RPS4X/RPL12/MRPS14/MRPL13/RPSA/RPS28/MRPL10/RPL7A/RPL39/MRPL2/RPL11/RPL22	72
KEGG	hsa04110	Cell cycle	59/2250	126/8135	2.978e-06	0.0003315	0.0002999	ESPL1/PKMYT1/BUB1B/TTK/CDK1/CDKN1A/GADD45G/E2F2/CDKN2B/CDC20/PTTG1/CCNA2/MCM4/BUB1/YWHAH/MCM5/CCNB2/CDC25A/YWHAE/CDC6/YWHAZ/SMC3/E2F1/PLK1/CDC25C/CDKN2C/GADD45A/ZBTB17/CCNB1/MCM2/DBF4/SFN/CDC45/CDK2/TGFB3/ORC1/CCNE2/MCM7/CDK7/TFDP2/CDKN2A/YWHAQ/ANAPC11/MCM3/CHEK1/RBL2/ANAPC1/CDC14B/MAD2L2/ATR/CHEK2/SMC1A/ATM/TGFB1/ANAPC13/ORC2/CDC25B/CCND1/CDC16	59
KEGG	hsa04115	p53 signaling pathway	38/2250	73/8135	8.322e-06	0.0006949	0.0006286	GTSE1/TP73/CDK1/CDKN1A/CASP9/GADD45G/CCNG2/PERP/CCNB2/DDB2/RRM2B/BAX/GADD45A/SERPINE1/PMAIP1/STEAP3/TP53I3/CCNB1/SFN/CDK2/CCNE2/IGFBP3/FAS/BID/TNFRSF10B/CD82/CDKN2A/MDM4/CHEK1/BCL2L1/RRM2/ATR/CHEK2/TP53AIP1/ATM/SHISA5/CCND1/SESN2	38
KEGG	hsa05140	Leishmaniasis	38/2250	77/8135	4.018e-05	0.002543	0.0023	IL1B/MAPK11/IL10/PTPN6/NCF4/TNF/CYBB/TLR4/HLA-DMA/NFKBIB/FCGR1A/MAPK12/TGFB3/HLA-DPA1/TLR2/HLA-DRA/IRAK1/EEF1A1/ELK1/JUN/TAB1/NFKBIA/HLA-DMB/CYBA/EEF1A2/HLA-DQA2/IFNGR1/IL4/PRKCB/HLA-DPB1/TRAF6/STAT1/NCF1/FOS/TGFB1/MAPK1/HLA-DRB1/JAK1	38
KEGG	hsa04640	Hematopoietic cell lineage	46/2250	99/8135	4.567e-05	0.002543	0.0023	IL1B/ANPEP/CD1E/CSF2/ITGA2/ITGA3/CSF1R/IL1R1/CSF3R/TFRC/CD9/TNF/CSF1/IL2RA/CD1A/HLA-DMA/CD1C/IL1R2/IL4R/FCGR1A/CD1B/CD33/IL9R/CD1D/FLT3/HLA-DPA1/ITGA1/ITGA6/HLA-DRA/CSF2RA/CD7/CD19/CR2/CD44/IL5RA/IL7R/HLA-DMB/IL11RA/IL7/CD3E/HLA-DQA2/IL4/CD34/ITGA2B/HLA-DPB1/HLA-DRB1	46
KEGG	hsa05171	Coronavirus disease - COVID-19	91/2250	232/8135	7.212e-05	0.003441	0.003113	HBEGF/IL1B/MAPK11/CSF2/NLRP3/ISG15/TLR8/RPL3/OAS2/RPS8/MX1/TNF/RPL32/RPS25/CYBB/TLR4/RPS12/CXCL10/RPL10A/RPS18/RPS27/RPL35/RPL38/RPS10/RPS3A/RPLP2/RPL21/NFKBIB/RPL19/STAT3/RPL23A/C1QB/RPS5/RPL36/RPL5/RPL4/RPL30/RPL27A/RPL26/RPS23/RPS6/RPS15/RPL36A/MAPK12/RPL7/RPL18A/CFD/RPS13/RPS20/RPL6/RPS3/RPS15A/CCL2/RPS27A/FAU/RPL23/RPS11/RPS19/PRKCA/UBA52/TLR2/RPS16/RPS9/IRAK1/RPL14/RPL37A/RPL37/JUN/C3AR1/NFKBIA/RPL29/RPS4X/IRF3/RPL12/OAS1/RPSA/CFB/RPS28/C1QA/RPL7A/C1R/RPL39/PRKCB/TRAF6/C6/STAT1/RPL11/FOS/MAPK1/RPL22/JAK1	91
KEGG	hsa05323	Rheumatoid arthritis	42/2250	93/8135	0.0002119	0.008848	0.008003	IL1B/VEGFA/CD86/IL18/CSF2/ICAM1/ACP5/CCL20/CCL3L3/CD80/IL17A/ATP6V0D1/TNF/CSF1/TLR4/ATP6V0B/HLA-DMA/CTLA4/CCL3/ATP6V1E1/TGFB3/ATP6V0C/CCL2/HLA-DPA1/ATP6V1A/TLR2/HLA-DRA/FLT1/CXCL2/CXCL3/JUN/HLA-DMB/HLA-DQA2/ATP6V1G1/TNFSF13/HLA-DPB1/ATP6V1E2/TNFSF11/FOS/TGFB1/HLA-DRB1/IL23A	42
KEGG	hsa04659	Th17 cell differentiation	47/2250	108/8135	0.0002687	0.009973	0.00902	EBI3/IL1B/MAPK11/IL21/IL1R1/IRF4/IL17A/NFKBIE/IL2RA/MTOR/FOXP3/IL2RB/HLA-DMA/NFKBIB/STAT3/IL4R/IL2RG/MAPK12/IL21R/RORC/HLA-DPA1/LAT/HLA-DRA/IL12RB1/IL27RA/RXRA/JUN/NFKBIA/HLA-DMB/IL22/CD3E/HLA-DQA2/IFNGR1/IL4/STAT5A/HLA-DPB1/STAT1/FOS/TGFB1/JAK3/RARA/MAPK1/HLA-DRB1/ZAP70/GATA3/JAK1/IL23A	47
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	85/2250	222/8135	0.0003189	0.01065	0.009634	EGR1/ESPL1/EGR2/RELB/BUB1B/CSF2/CDKN1A/ICAM1/FOSL1/IL1R1/E2F2/CDKN2B/SRF/CDC20/PTTG1/CCNA2/SPI1/CCNB2/NFKB2/CREB3L2/TNF/ZFP36/E2F1/IL2RA/AKT3/BAX/CDKN2C/IL2RB/HLA-DMA/CRTC2/IL1R2/MSX1/FDPS/ADCY4/TSPO/HLA-G/IL2RG/CDK2/TGFB3/KAT2A/ADCY6/ATF4/CCNE2/CRTC1/ELK4/IL15RA/HLA-DPA1/HLA-E/HLA-DRA/CDKN2A/LTA/ANAPC11/VDAC1/ELK1/JUN/SLC25A5/CHEK1/NFKBIA/ADCY3/HLA-DMB/BCL2L1/MAP3K3/MAP2K4/ANAPC1/CD3E/HLA-DQA2/CANX/STAT5A/PRKACB/ATR/CHEK2/HLA-DPB1/ADCY9/SLC25A4/FOS/ATM/TGFB1/ANAPC13/JAK3/MAPK1/CCND1/HLA-DRB1/CDC16/NFYB/JAK1	85
KEGG	hsa04658	Th1 and Th2 cell differentiation	41/2250	92/8135	0.0003547	0.01077	0.009741	MAPK11/NOTCH1/JAG2/MAML1/NFKBIE/IL2RA/IL2RB/HLA-DMA/NFKBIB/IL4R/MAML2/IL2RG/MAPK12/IL12RB2/RBPJ/JAG1/HLA-DPA1/LAT/HLA-DRA/IL12RB1/JUN/STAT4/NFKBIA/MAF/HLA-DMB/CD3E/HLA-DQA2/IL13/IFNGR1/IL4/STAT5A/HLA-DPB1/STAT1/FOS/DLL1/JAK3/MAPK1/HLA-DRB1/ZAP70/GATA3/JAK1	41
KEGG	hsa05202	Transcriptional misregulation in cancer	75/2250	193/8135	0.0004209	0.01171	0.0106	ETV7/CD86/CSF2/CDKN1A/NR4A3/PPARG/GADD45G/CSF1R/NTRK1/DOT1L/PDGFA/CCNA2/BCL6/DUSP6/SPI1/BMP2K/MMP9/PML/DDB2/KLF3/BAX/CDKN2C/GADD45A/PLAU/ZBTB17/IL2RB/AFF1/IL1R2/FCGR1A/PLAT/ETV5/TFE3/IGF1R/LYL1/PER2/IGFBP3/CDK14/FLT3/SPINT1/RUNX2/FOXO1/ELK4/CCNT2/SUPT3H/BCL2A1/EWSR1/SLC45A3/BAK1/SS18/SP1/DDIT3/FLT1/RXRA/TRAF1/MAF/CEBPB/MPO/BCL2L1/BIRC3/SMAD1/MLLT3/DEFA1B/HOXA11/MAX/NUPR1/DEFA4/HPGD/PBX1/ATM/ARNT2/RARA/BMI1/LDB1/NCOR1/TLX3	75
KEGG	hsa01232	Nucleotide metabolism	38/2250	85/8135	0.0005331	0.0137	0.01239	DCTPP1/ENTPD1/TYMP/CANT1/TYMS/TK1/RRM2B/ENTPD5/CMPK2/DTYMK/NUDT16/AK5/RRM1/HPRT1/ENTPD2/AK3/PNP/NME4/DCTD/ASMTL/AMPD2/NME3/AK4/APRT/IMPDH1/ENTPD4/RRM2/GUK1/AMPD3/LACC1/NT5E/AK1/CMPK1/CTPS2/UCK2/AK2/NT5C2/NME2	38
KEGG	hsa00511	Other glycan degradation	12/2250	18/8135	0.0006326	0.01509	0.01365	NEU4/GLB1/NEU1/MAN2B1/ENGASE/FUCA2/GBA/NEU3/AGA/HEXB/MANBA/FUCA1	12
KEGG	hsa05212	Pancreatic cancer	34/2250	76/8135	0.001011	0.0225	0.02036	VEGFA/CDKN1A/CASP9/GADD45G/E2F2/RAC1/DDB2/E2F1/BRCA2/AKT3/BAX/GADD45A/MTOR/RAD51/STAT3/TGFB3/RALGDS/BAK1/CDKN2A/RALA/ERBB2/RAC2/BCL2L1/BRAF/STAT1/RALB/TGFB1/CDC42/MAPK1/CCND1/BAD/RALBP1/RAC3/JAK1	34
KEGG	hsa05145	Toxoplasmosis	46/2250	112/8135	0.001409	0.0294	0.0266	PPIF/MAPK11/CASP9/IL10/HSPA2/TNF/HSPA1A/TLR4/AKT3/LDLR/HLA-DMA/NFKBIB/STAT3/MAP2K3/MAPK12/TGFB3/CCR5/MAP2K6/PIK3R5/HLA-DPA1/ITGA6/TLR2/HLA-DRA/ALOX5/IRAK1/GNAI2/TAB1/NFKBIA/HLA-DMB/BCL2L1/BIRC3/HLA-DQA2/HSPA6/IFNGR1/HSPA1L/HLA-DPB1/TRAF6/BIRC7/STAT1/IL10RA/TGFB1/MAPK1/HLA-DRB1/LAMA5/BAD/JAK1	46
KEGG	hsa04145	Phagosome	59/2250	152/8135	0.001709	0.03176	0.02873	TUBB6/ITGA2/RAC1/MRC1/ATP6V0D1/OLR1/TFRC/NCF4/TUBA1B/CLEC7A/TUBA1C/CYBB/TLR4/ATP6V0B/HLA-DMA/ACTG1/TUBB/FCGR1A/HLA-G/SEC61A2/ATP6V1E1/TUBB4B/THBS2/ATP6V0C/PIKFYVE/M6PR/HLA-DPA1/CORO1A/HLA-E/ATP6V1A/TUBB3/TLR2/HLA-DRA/SEC61B/HGS/STX12/TAP1/TLR6/TUBB2A/TUBB4A/VAMP3/FCAR/HLA-DMB/MPO/CYBA/HLA-DQA2/ATP6V1G1/LAMP1/PIK3C3/EEA1/C1R/CANX/COLEC12/HLA-DPB1/ATP6V1E2/NCF1/THBS4/HLA-DRB1/ACTB	59
KEGG	hsa04062	Chemokine signaling pathway	72/2250	192/8135	0.001712	0.03176	0.02873	CXCL13/RASGRP2/GNG4/CCL20/CCL3L3/HCK/RAC1/CXCR6/CCL22/CCR1/GNG10/AKT3/CXCL10/NFKBIB/STAT3/ADCY4/CCR6/CCR2/SRC/CCR4/SHC4/TIAM1/ARRB1/CCL3/GNG7/PAK1/ADCY6/CCR5/PIK3R5/CCL2/PREX1/CCL17/VAV2/CCL18/CXCL9/CXCL16/GNAI2/CXCL2/CXCL3/NFKBIA/CRK/RAC2/CCR8/ADCY3/GNB4/ITK/GSK3A/BRAF/GRK5/PRKCB/PRKACB/GNAQ/CCL23/ADCY9/STAT1/NCF1/CCL7/PPBP/GRK6/PLCB1/CDC42/CCL15/SHC2/WAS/JAK3/MAPK1/CXCR5/SHC1/CCL27/CX3CR1/BAD/RAC3	72
KEGG	hsa04060	Cytokine-cytokine receptor interaction	104/2250	295/8135	0.002213	0.0389	0.03518	CXCL13/EBI3/LIF/IL1B/IL18/CSF2/IL21/CSF2RB/CSF1R/IL10/IL1R1/CCL20/CCL3L3/CXCR6/IL17A/TNFRSF18/IL1RN/CSF3R/CCL22/TNFSF4/CNTF/CCR1/TNFRSF12A/TNF/RELT/CSF1/TNFRSF4/IL2RA/TNFRSF8/CXCL10/TNFRSF21/IL2RB/IL17RE/IL1R2/IL4R/CCR6/CCR2/CCR4/CCL3/IL2RG/IL12RB2/TGFB3/IL9R/IL21R/CCR5/CCL2/TNFRSF19/CCL17/IL15RA/FAS/TNFRSF10B/TNFRSF9/CCL18/CXCL9/CXCL16/CSF2RA/IL12RB1/IL27RA/IL26/OSM/TNFRSF13B/LTA/IL18R1/CXCL2/GDF7/CXCL3/ACVR1C/ACVR2B/IL17RC/TNFSF12/IL5RA/IL7R/CCR8/IL22/TNFSF9/IL11RA/IL7/IL13/IL20/IFNGR1/TNFSF13/IL4/TNFRSF11B/TNFRSF1B/TNFSF10/IL36A/BMP10/CCL23/IL17C/BMP3/IL10RA/TNFSF11/EDAR/CCL7/PPBP/TGFB1/CCL15/IL32/CXCR5/CCL27/CX3CR1/TNFRSF25/IL37/IL23A	104
KEGG	hsa04210	Apoptosis	53/2250	136/8135	0.002587	0.04122	0.03728	PTPN13/CSF2RB/BIRC5/CASP9/GADD45G/LMNB1/NTRK1/CTSH/MCL1/TUBA1B/TUBA1C/TNF/AKT3/BAX/GADD45A/LMNB2/PMAIP1/CAPN1/ACTG1/LMNA/CTSO/PARP2/CFLAR/ATF4/CTSF/CTSB/CTSW/FAS/BID/TNFRSF10B/MAP3K5/BCL2A1/SPTAN1/BAK1/CTSD/DDIT3/JUN/NFKBIA/TRAF1/CTSZ/BCL2L1/DFFB/BIRC3/TRAF2/EIF2AK3/ERN1/TNFSF10/TP53AIP1/FOS/ATM/MAPK1/BAD/ACTB	53
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	41/2250	100/8135	0.002591	0.04122	0.03728	CXCL13/IL18/CSF1R/IL10/CCL20/CCL3L3/CCL22/CCR1/TNF/CSF1/IL2RA/CXCL10/IL2RB/CCR6/CCR2/CCR4/CCL3/IL2RG/CCR5/CCL2/CCL17/TNFRSF10B/CCL18/CXCL9/LTA/IL18R1/CXCL2/CXCL3/CCR8/IL20/TNFRSF1B/TNFSF10/CCL23/IL10RA/CCL7/PPBP/CCL15/CXCR5/CCL27/CX3CR1/IL37	41
KEGG	hsa01522	Endocrine resistance	40/2250	98/8135	0.003196	0.04852	0.04389	HBEGF/MAPK11/NOTCH1/JAG2/CDKN1A/E2F2/MMP9/E2F1/AKT3/BAX/CDKN2C/MTOR/ADCY4/SRC/SHC4/GNAS/MAPK12/IGF1R/ADCY6/BIK/JAG1/CARM1/CDKN2A/SP1/JUN/ERBB2/ADCY3/BRAF/ESR1/PRKACB/ADCY9/CYP2D6/FOS/DLL1/SHC2/MAPK1/CCND1/SHC1/NCOR1/BAD	40
KEGG	hsa05168	Herpes simplex virus 1 infection	162/2250	495/8135	0.005932	0.08614	0.07791	IL1B/IRF7/ZNF267/CASP9/OAS2/ZNF257/PML/EIF4EBP1/TNF/PPP1CB/AKT3/BAX/MTOR/HLA-DMA/ZNF559/ZNF543/CARD9/ZNF212/ZNF282/SRC/SOCS3/ZNF846/POU2F1/ZNF443/HLA-G/BST2/ZNF764/ZNF620/ZFP1/SRSF4/CD74/ZNF419/ZNF597/ZNF510/EIF2B3/ZNF251/ZNF550/ZNF85/CCL2/ZNF100/ZNF689/FAS/BID/HLA-DPA1/ZNF304/ZNF302/ZNF468/ZNF729/ZNF565/ZFP14/HLA-E/ZNF3/ZNF613/TLR2/ZNF7/HLA-DRA/ZNF790/ZNF429/ZNF417/BAK1/ZNF746/ZNF599/ZNF248/ZNF596/IRAK1/ZNF610/ZNF783/LTA/TAP1/ZNF234/ZNF343/ZNF19/ZNF829/TAB1/NFKBIA/ZNF317/ZNF235/ZNF777/ZNF571/HLA-DMB/ZNF589/ZNF205/BCL2L1/IRF3/ZNF415/ZNF567/ZNF93/BIRC3/HLA-DQA2/ZNF737/OAS1/ZNF91/ZNF768/ZNF79/ZNF547/ZNF320/ZNF786/ZNF701/TRAF2/ZNF398/IFNGR1/ZNF254/EIF2AK3/ZNF551/ZNF17/ZNF98/ZNF530/ZNF816/ZNF442/ZNF492/ZNF224/ZNF619/ZNF616/ZNF684/ZNF383/ZNF77/ZNF416/ZNF799/HLA-DPB1/TRAF6/ZNF823/ZNF879/ZNF623/ZNF540/ZNF878/ZNF569/ZNF765/ZNF549/STAT1/ZNF585A/ZNF749/ZNF460/ZNF124/ZNF440/ZNF813/ZNF836/ZNF675/ZIK1/ZNF688/ZNF84/POU2F2/ZNF578/ZNF564/ZNF805/ZNF44/ZNF41/ZNF253/ZNF420/ZNF614/ZFP92/HLA-DRB1/ZNF611/ZNF30/BAD/ZNF557/ZNF180/ZNF713/ZFP57/ZNF716/JAK1/NXF3/ZNF709	162
KEGG	hsa04142	Lysosome	50/2250	132/8135	0.006479	0.09017	0.08156	NAGA/CD68/ACP5/CTSH/ATP6V0D1/CTSA/GLB1/CLTB/GM2A/NEU1/TPP1/ATP6V0B/CTNS/HYAL3/IDS/CTSO/IDUA/PPT1/GGA2/MAN2B1/CTSF/CTSB/ATP6V0C/CTSW/M6PR/FUCA2/SUMF1/AP3D1/AP1S1/LITAF/GBA/CTSD/NAPSA/CTSZ/AP4M1/AP3M2/PLA2G15/ENTPD4/LAMP1/DMXL1/GALC/AGA/HEXB/GUSB/LIPA/LAPTM4A/MANBA/DMXL2/FUCA1/AP3B2	50
KEGG	hsa04216	Ferroptosis	19/2250	41/8135	0.007992	0.1032	0.09336	TFRC/CYBB/MAP1LC3A/STEAP3/HMOX1/SLC3A2/ACSL1/SAT1/LPCAT3/FTL/GPX4/NCOA4/FTH1/ACSL4/PRNP/GCLC/GSS/ATG7/SLC40A1	19
KEGG	hsa00240	Pyrimidine metabolism	25/2250	58/8135	0.008035	0.1032	0.09336	DCTPP1/ENTPD1/TYMP/CANT1/TYMS/DHODH/TK1/RRM2B/ENTPD5/CMPK2/DTYMK/RRM1/NME4/DCTD/ASMTL/NME3/DPYD/ENTPD4/RRM2/NT5E/CMPK1/CTPS2/UCK2/NT5C2/NME2	25
KEGG	hsa04668	TNF signaling pathway	43/2250	112/8135	0.008461	0.1047	0.09467	LIF/IL1B/MAPK11/CSF2/ICAM1/CCL20/BCL3/MMP9/CREB3L2/TNF/CSF1/AKT3/CXCL10/BAG4/RIPK3/SOCS3/MAP2K3/CFLAR/MAPK12/ATF4/MAP2K6/CCL2/JAG1/FAS/MAP3K5/NOD2/LTA/IL18R1/CXCL2/CXCL3/JUN/TAB1/NFKBIA/TRAF1/CEBPB/MAP2K4/BIRC3/TRAF2/TNFRSF1B/FOS/PGAM5/MAPK1/VEGFC	43
KEGG	hsa05130	Pathogenic Escherichia coli infection	70/2250	197/8135	0.008815	0.1051	0.09511	TUBB6/IL1B/MAPK11/IL18/NLRP3/CASP9/IL1R1/RAC1/PTPN6/GAPDH/CYFIP1/TIRAP/TUBA1B/MYO1E/TUBA1C/SEC24D/MYH10/TNF/TLR4/CTTN/BAX/WIPF2/MYO5C/ACTG1/NFKBIB/TUBB/CYTH2/CYFIP2/MYO5A/SRC/ARHGEF12/ARHGEF2/MAPK12/TUBB4B/PAK1/RPS3/ARPC1B/PAK3/FAS/TNFRSF10B/EZR/TUBB3/NCL/ARPC5/BAK1/IRAK1/TUBB2A/JUN/TUBB4A/TAB1/TMED10/NFKBIA/ACTR3B/CLDN7/TRAF2/MYH9/F2R/TNFSF10/CYTH1/TRAF6/ARF6/RAB1A/WASF2/FOS/CDC42/MAPK1/CLDN4/FYN/PAK2/ACTB	70
KEGG	hsa04380	Osteoclast differentiation	48/2250	128/8135	0.009323	0.1074	0.09712	IL1B/MAPK11/RELB/PPARG/FOSL1/SQSTM1/CSF1R/IL1R1/ACP5/RAC1/SPI1/SIRPA/NCF4/FOSB/NFKB2/TNF/CSF1/AKT3/LILRA2/GAB2/FCGR1A/SOCS3/LILRB4/BTK/MAPK12/MAP2K6/CYLD/LILRB2/FOSL2/JUN/TAB1/NFKBIA/CYBA/LILRA6/LILRA5/TRAF2/IFNGR1/TNFRSF11B/TYROBP/TRAF6/STAT1/TNFSF11/NCF1/FOS/TGFB1/MAPK1/FYN/JAK1	48
KEGG	hsa05169	Epstein-Barr virus infection	71/2250	202/8135	0.01109	0.123	0.1112	MAPK11/IRF7/RELB/CDKN1A/ICAM1/CASP9/GADD45G/E2F2/RAC1/ISG15/CCNA2/ENTPD1/OAS2/DDB2/NFKB2/TNF/E2F1/NFKBIE/AKT3/BAX/CXCL10/GADD45A/HLA-DMA/NFKBIB/STAT3/MAP2K3/HLA-G/PSMD8/BTK/CDK2/MAPK12/PSMD1/PSMD2/RBPJ/CCNE2/MAP2K6/FAS/BID/HLA-DPA1/HLA-E/TLR2/HLA-DRA/CD58/BAK1/IRAK1/CD19/TAP1/JUN/CR2/TAB1/CD44/NFKBIA/HLA-DMB/SAP30L/IRF3/VIM/MAP2K4/CD3E/HLA-DQA2/OAS1/TRAF2/HLA-DPB1/TRAF6/STAT1/PSMD7/JAK3/CCND1/HLA-DRB1/PSMC5/JAK1/PSMD11	71
KEGG	hsa05152	Tuberculosis	64/2250	180/8135	0.01171	0.123	0.1112	VDR/IL1B/MAPK11/IL18/CASP9/IL10/MRC1/ATP6V0D1/TIRAP/CLEC7A/KSR1/TNF/TLR4/AKT3/BAX/ATP6V0B/LSP1/HLA-DMA/CARD9/ITGAX/FCGR1A/SRC/ARHGEF12/RFXANK/HSPA9/CALML4/CAMK2A/MAPK12/TGFB3/CD74/ATP6V0C/BID/HLA-DPA1/CORO1A/TLR2/HLA-DRA/NOD2/IRAK1/CTSD/TLR6/CYP27B1/CAMK2G/CEBPB/HLA-DMB/HLA-DQA2/LAMP1/PIK3C3/IFNGR1/CAMK2D/RIPK2/EEA1/RFXAP/HLA-DPB1/TRAF6/SPHK2/STAT1/IL10RA/TGFB1/MAPK1/HLA-DRB1/NFYB/BAD/JAK1/IL23A	64
KEGG	hsa04120	Ubiquitin mediated proteolysis	52/2250	142/8135	0.01178	0.123	0.1112	UBE2C/CDC20/UBE2A/PML/UBE2S/DDB2/UBE2B/PIAS3/DET1/SYVN1/SAE1/SOCS3/UBE2H/UBE2I/UBB/UBA7/HERC3/UBE2N/KLHL9/RPS27A/UBE4A/SMURF1/UBE2G2/PIAS1/UBA52/ERCC8/MID1/ANAPC11/UBE3A/MGRN1/FBXW11/PIAS2/CUL5/BIRC3/ANAPC1/RNF7/PRPF19/BTRC/PIAS4/TRAF6/BIRC7/UBE3B/HERC2/ANAPC13/CUL4A/UBOX5/UBA6/CDC16/UBE2F/FBXO4/KLHL13/UBE2W	52
KEGG	hsa00480	Glutathione metabolism	24/2250	58/8135	0.01645	0.1664	0.1506	ANPEP/CHAC1/LAP3/RRM2B/GPX1/CHAC2/GGT1/SMS/RRM1/OPLAH/GSTO1/GPX4/GSTM1/TXNDC12/RRM2/PRDX6/GSTT1/MGST2/GCLC/GGT7/MGST3/GSTK1/PGD/GSS	24
KEGG	hsa05418	Fluid shear stress and atherosclerosis	50/2250	139/8135	0.01904	0.187	0.1692	IL1B/MAPK11/VEGFA/SDC4/ICAM1/SQSTM1/KLF2/IL1R1/PDGFA/RAC1/GPC1/MMP9/TNF/AKT3/ACTG1/IL1R2/PLAT/SRC/HMOX1/ARHGEF2/SUMO4/CALML4/MAPK12/SDC2/SUMO3/MAP2K6/CCL2/NQO1/SDC1/GSTO1/MAP3K5/SUMO1/JUN/ACVR2B/RAC2/GSTM1/CYBA/MAP2K4/PIAS4/GSTT1/MGST2/ITGA2B/MGST3/NCF1/FOS/CDH5/PDGFB/RAC3/ACTB/DUSP1	50
KEGG	hsa05417	Lipid and atherosclerosis	73/2250	215/8135	0.02358	0.2172	0.1965	IL1B/MAPK11/IRF7/IL18/PPARG/NLRP3/ICAM1/CASP9/HSPA2/ABCG1/CCL3L3/RAC1/OLR1/TIRAP/NCF4/MMP9/HSPA5/TNF/HSPA1A/CYBB/TLR4/AKT3/BAX/LDLR/STAT3/SRC/POU2F1/MAP2K3/CALML4/CCL3/CAMK2A/MAPK12/ATF4/MAP2K6/CCL2/FAS/BID/TNFRSF10B/MAP3K5/VAV2/PRKCA/TLR2/ABCA1/TANK/IRAK1/DDIT3/RXRA/CXCL2/TLR6/CXCL3/JUN/TAB1/CAMK2G/NFKBIA/BCL2L1/CYBA/IRF3/MAP2K4/HSPA6/TRAF2/EIF2AK3/CAMK2D/ERN1/TNFSF10/HSPA1L/TRAF6/NCF1/FOS/POU2F2/PLCB1/CDC42/MAPK1/BAD	73
KEGG	hsa04114	Oocyte meiosis	47/2250	131/8135	0.02359	0.2172	0.1965	ESPL1/PKMYT1/MAPK11/CDK1/AURKA/CDC20/PTTG1/BUB1/YWHAH/CCNB2/YWHAE/PPP2R1A/YWHAZ/SMC3/PPP1CB/FBXO43/PLK1/CDC25C/ADCY4/CCNB1/FBXO5/CALML4/CDK2/CAMK2A/MAPK12/IGF1R/ADCY6/CCNE2/PPP2CA/YWHAQ/ANAPC11/REC8/FBXW11/CAMK2G/ADCY3/STAG3/ANAPC1/BTRC/CAMK2D/CPEB1/MAD2L2/PRKACB/ADCY9/SMC1A/ANAPC13/MAPK1/CDC16	47
KEGG	hsa04066	HIF-1 signaling pathway	40/2250	109/8135	0.02406	0.2172	0.1965	VEGFA/CDKN1A/GAPDH/HK1/LDHA/PFKFB3/TFRC/ENO1/PFKP/EIF4EBP1/HK2/CYBB/TLR4/AKT3/SERPINE1/MTOR/STAT3/LDHAL6B/HMOX1/ALDOC/RPS6/CAMK2A/PDHB/IGF1R/PRKCA/ENO3/FLT1/MKNK1/ERBB2/TIMP1/CAMK2G/ALDOA/IFNGR1/CAMK2D/EIF4E2/PRKCB/INSR/PFKL/ALDOB/MAPK1	40
KEGG	hsa04137	Mitophagy - animal	28/2250	72/8135	0.02497	0.2191	0.1982	SQSTM1/BNIP3L/E2F1/MAP1LC3A/NBR1/SRC/TFE3/ATG9A/UBB/BCL2L13/ATF4/AMBRA1/CALCOCO2/RPS27A/PINK1/UBA52/MRAS/ULK1/SP1/JUN/CITED2/BCL2L1/TFEB/EIF2AK3/RHOT2/PGAM5/RRAS2/FUNDC1	28
KEGG	hsa05416	Viral myocarditis	24/2250	60/8135	0.02558	0.2191	0.1982	CD86/ICAM1/CASP9/CD80/RAC1/SGCB/HLA-DMA/ACTG1/HLA-G/BID/HLA-DPA1/HLA-E/HLA-DRA/MYH7/RAC2/HLA-DMB/HLA-DQA2/HLA-DPB1/MYH6/CCND1/HLA-DRB1/FYN/RAC3/ACTB	24
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	10/2250	20/8135	0.02788	0.2328	0.2106	CHST15/CHPF2/B3GAT3/CSGALNACT1/B3GALT6/CHST7/CHPF/CHST13/XYLT1/B4GALT7	10
KEGG	hsa00010	Glycolysis / Gluconeogenesis	26/2250	67/8135	0.03085	0.2513	0.2273	TPI1/GAPDH/HK1/LDHA/ENO1/PGAM1/PFKP/GPI/HK2/LDHAL6B/PKM/ALDOC/PDHB/ALDH2/DLAT/ENO3/GALM/ALDOA/ALDH3A1/ALDH3B1/ACSS1/ALDH7A1/ALDH9A1/PFKL/ALDOB/AKR1A1	26
KEGG	hsa04015	Rap1 signaling pathway	70/2250	210/8135	0.03893	0.2928	0.2649	RASGRP2/MAPK11/VEGFA/ADORA2A/CSF1R/FPR1/SIPA1L1/PDGFA/RAC1/CSF1/SIPA1L2/AKT3/ACTG1/ADCY4/SRC/TIAM1/MAP2K3/CALML4/GNAS/MAPK12/RAPGEF5/IGF1R/APBB1IP/FGF9/ADCY6/PFN2/MAP2K6/VAV2/PRKD3/PRKCA/VASP/PRKCI/LAT/MRAS/RALGDS/RALA/FLT1/GNAI2/CNR1/RAPGEF1/ARAP3/CRK/RAC2/ADCY3/PARD6G/FLT4/RAPGEF2/BRAF/KRIT1/F2R/FGF22/ITGA2B/PRKCB/P2RY1/PARD6B/GNAQ/INSR/ADCY9/FGF8/PARD6A/RALB/PLCB1/ID1/CDC42/MAPK1/PDGFB/VEGFC/MAGI1/RAC3/ACTB	70
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	38/2250	106/8135	0.03929	0.2928	0.2649	VDR/EGR1/HBEGF/CDKN1A/PDE4A/CREB3L2/ADCY4/PDE4D/ARRB1/GNAS/PDE4B/PTHLH/ADCY6/ATF4/RUNX2/CASR/PRKCA/MEF2D/SP1/RXRA/GNAI2/CYP27B1/ADCY3/MMP24/BRAF/BGLAP/LRP6/PRKCB/PRKACB/GNAQ/ADCY9/AKAP13/TNFSF11/FOS/PLCB1/MAPK1/GATA3/GCM1	38
KEGG	hsa05110	Vibrio cholerae infection	20/2250	50/8135	0.03941	0.2928	0.2649	ATP6V0D1/ATP6V0B/TJP2/ACTG1/SLC12A2/KDELR2/GNAS/SEC61A2/ATP6V1E1/PDIA4/ATP6V0C/PRKCA/ATP6V1A/SEC61B/ADCY3/ATP6V1G1/PRKACB/ADCY9/ATP6V1E2/ACTB	20
KEGG	hsa03420	Nucleotide excision repair	19/2250	47/8135	0.03946	0.2928	0.2649	DDB2/RFC2/CDK7/RAD23B/ERCC8/POLD4/ERCC5/POLE/ERCC2/RAD23A/GTF2H2/GTF2H1/MNAT1/CETN2/GTF2H5/XPA/CUL4A/ERCC1/POLE2	19
KEGG	hsa04064	NF-kappa B signaling pathway	37/2250	104/8135	0.04641	0.3369	0.3048	IL1B/RELB/ICAM1/GADD45G/IL1R1/TIRAP/EDARADD/NFKB2/TNF/TLR4/GADD45A/PLAU/TRIM25/CFLAR/BTK/UBE2I/CYLD/LAT/BCL2A1/IRAK1/LTA/CXCL2/CXCL3/TAB1/NFKBIA/TRAF1/BCL2L1/BIRC3/TRAF2/CARD11/PIAS4/PRKCB/TRAF6/TNFSF11/EDAR/ATM/ZAP70	37
KEGG	hsa04218	Cellular senescence	53/2250	156/8135	0.04752	0.3377	0.3054	MAPK11/FOXM1/CDK1/CDKN1A/GADD45G/SQSTM1/E2F2/CDKN2B/CCNA2/MYBL2/CCNB2/CDC25A/EIF4EBP1/E2F1/PPP1CB/AKT3/GADD45A/SERPINE1/MTOR/CAPN1/CCNB1/MAP2K3/HLA-G/CALML4/CDK2/MAPK12/TGFB3/CCNE2/MAP2K6/IGFBP3/FOXO1/ZFP36L2/HLA-E/MRAS/CDKN2A/VDAC1/SLC25A5/FBXW11/CHEK1/RBL2/BTRC/MAPKAPK2/ZFP36L1/ATR/CHEK2/SLC25A4/ATM/TGFB1/MAPK1/CCND1/RRAS2/RAD9A/SIRT1	53
KEGG	hsa05135	Yersinia infection	47/2250	137/8135	0.0508	0.3446	0.3117	IL1B/MAPK11/IL18/NLRP3/IL10/RAC1/TNF/TLR4/AKT3/WIPF2/ACTG1/SRC/ARHGEF12/RHOG/MAP2K3/MAPK12/DOCK1/MAP2K6/CCL2/ARPC1B/VAV2/PIP5K1B/LAT/ARPC5/IRAK1/LIMK1/JUN/TAB1/NFKBIA/CRK/RAC2/ACTR3B/IRF3/MAP2K4/TRAF2/GNAQ/TRAF6/ARF6/WASF2/FOS/PIP5K1A/CDC42/WAS/MAPK1/ZAP70/RAC3/ACTB	47
KEGG	hsa03013	Nucleocytoplasmic transport	38/2250	108/8135	0.05165	0.3446	0.3117	SEC13/KPNA2/NUP98/CSE1L/SUMO4/RNPS1/UBE2I/SUMO3/NUP153/UPF1/MAGOHB/XPO6/NUP88/THOC3/SUMO1/EEF1A1/KPNA3/POM121C/NUP205/RAE1/NUP50/EEF1A2/UPF3A/MAGOH/POM121L2/PNN/GLE1/SNUPN/NUP93/DDX19A/NUP35/AAAS/NCBP2/TMEM33/NUP62/TNPO1/SEH1L/NXF3	38
KEGG	hsa05222	Small cell lung cancer	33/2250	92/8135	0.05169	0.3446	0.3117	CDKN1A/ITGA2/CASP9/GADD45G/ITGA3/E2F2/CDKN2B/DDB2/E2F1/AKT3/BAX/GADD45A/ZBTB17/CKS2/CDK2/CKS1B/CCNE2/COL4A6/ITGA6/BAK1/TRAF4/RXRA/NFKBIA/TRAF1/BCL2L1/BIRC3/TRAF2/ITGA2B/MAX/TRAF6/BIRC7/CCND1/LAMA5	33
KEGG	hsa05221	Acute myeloid leukemia	25/2250	67/8135	0.05376	0.3446	0.3117	CSF2/CSF1R/CCNA2/DUSP6/SPI1/PML/EIF4EBP1/AKT3/MTOR/STAT3/FCGR1A/PIM1/PIM2/PER2/FLT3/TCF7L2/BCL2A1/MPO/BRAF/STAT5A/PPARD/RARA/MAPK1/CCND1/BAD	25
KEGG	hsa04010	MAPK signaling pathway	94/2250	294/8135	0.05428	0.3446	0.3117	NR4A1/RASGRP2/IL1B/MAPK11/VEGFA/RELB/DUSP10/GADD45G/DUSP4/NTRK2/CSF1R/HSPA2/IL1R1/NTRK1/SRF/PDGFA/RAC1/DUSP6/PTPN7/NFKB2/TNF/CSF1/HSPA1A/AKT3/GADD45A/MAP3K6/MAP2K3/DUSP5/ARRB1/MAP3K2/MAPK12/IGF1R/TGFB3/PAK1/FGF9/ATF4/MAP2K6/FLT3/RASGRF2/ELK4/FAS/DUSP16/MAP3K5/PRKCA/STK3/STMN1/CACNG3/MRAS/MAP3K11/IRAK1/DDIT3/FLT1/CACNA2D2/RASGRP4/TAOK3/ELK1/JUN/MKNK1/PPP5C/ERBB2/TAB1/CRK/RAC2/MAP3K3/MAP2K4/FLT4/HSPA6/RAPGEF2/BRAF/ECSIT/TRAF2/MAP4K1/MAPKAPK2/FGF22/HSPA1L/PRKCB/PRKACB/INSR/MAX/TRAF6/FGF8/CACNB2/NTF3/FOS/TGFB1/CDC42/CDC25B/MAPK1/PDGFB/VEGFC/RRAS2/PAK2/RAC3/DUSP1	94
KEGG	hsa05142	Chagas disease	36/2250	102/8135	0.05467	0.3446	0.3117	IL1B/MAPK11/GNA15/IL10/CCL3L3/PPP2R1A/TNF/TLR4/AKT3/SERPINE1/C1QB/CFLAR/GNAS/CCL3/MAPK12/TGFB3/CCL2/FAS/TLR2/PPP2CA/IRAK1/BDKRB2/GNAI2/TLR6/JUN/NFKBIA/MAP2K4/CD3E/IFNGR1/C1QA/GNAQ/TRAF6/FOS/PLCB1/TGFB1/MAPK1	36
KEGG	hsa04510	Focal adhesion	66/2250	201/8135	0.05859	0.3614	0.3268	VEGFA/ITGA2/ITGA3/PDGFA/RAC1/ZYX/COL9A2/SPP1/COL6A2/PPP1CB/AKT3/ITGB8/ACTG1/MYLK2/SRC/SHC4/MYL12B/PAK4/DOCK1/IGF1R/PAK1/THBS2/COL6A1/ARHGAP35/PAK3/ARHGAP5/COL4A6/VAV2/PRKCA/ITGA1/VASP/PARVB/ITGA6/ACTN4/PIP5K1B/VTN/FLT1/RAPGEF1/ELK1/JUN/ERBB2/CRK/RAC2/BIRC3/FLT4/BRAF/ITGA2B/PRKCB/PPP1R12B/THBS4/PIP5K1A/CDC42/SHC2/PPP1R12A/MAPK1/CCND1/LAMA5/PDGFB/SHC1/VEGFC/BAD/FYN/PAK2/ILK/RAC3/ACTB	66
KEGG	hsa05225	Hepatocellular carcinoma	56/2250	168/8135	0.05958	0.3614	0.3268	CDKN1A/GADD45G/E2F2/DPF3/DDB2/E2F1/AKT3/PHF10/BAX/GADD45A/MTOR/WNT10B/SMARCB1/ACTG1/HMOX1/SHC4/DVL3/IGF1R/TGFB3/FZD6/ACTL6A/NQO1/TCF7L2/GSTO1/SMARCA4/PRKCA/DVL1/BAK1/CDKN2A/WNT7A/FRAT1/ARID1A/FZD8/ELK1/TXNRD3/GSTM1/BCL2L1/BRAF/GSTT1/DPF1/FZD9/MGST2/LRP6/PRKCB/APC/AXIN2/MGST3/FZD5/TXNRD2/TGFB1/SHC2/MAPK1/CCND1/SHC1/BAD/ACTB	56
KEGG	hsa05310	Asthma	13/2250	31/8135	0.06105	0.3614	0.3268	IL10/TNF/FCER1A/HLA-DMA/PRG2/HLA-DPA1/HLA-DRA/HLA-DMB/HLA-DQA2/IL13/IL4/HLA-DPB1/HLA-DRB1	13
KEGG	hsa05216	Thyroid cancer	15/2250	37/8135	0.06167	0.3614	0.3268	CDKN1A/PPARG/GADD45G/NTRK1/CCDC6/DDB2/BAX/GADD45A/TCF7L2/BAK1/RXRA/NCOA4/BRAF/MAPK1/CCND1	15
KEGG	hsa05170	Human immunodeficiency virus 1 infection	69/2250	212/8135	0.06408	0.3655	0.3306	GNG4/MAPK11/CDK1/CASP9/RAC1/CCNB2/APOBEC3H/GNG10/TNF/TLR4/AKT3/BAX/CDC25C/MTOR/APOBEC3B/CCNB1/MAP2K3/HLA-G/CALML4/PAK4/MAPK12/BST2/GNG7/PAK1/CCR5/MAP2K6/PAK3/FAS/BID/PRKCA/HLA-E/CFL1/TLR2/AP1S1/BAK1/IRAK1/LIMK1/LIMK2/TAP1/GNAI2/JUN/FBXW11/TAB1/CHEK1/NFKBIA/CRK/RAC2/CUL5/GNB4/BCL2L1/IRF3/SAMHD1/CD3E/RNF7/BTRC/TRAF2/TNFRSF1B/PRKCB/ATR/GNAQ/TRAF6/FOS/ATM/CUL4A/MAPK1/BAD/PAK2/RAC3/TRIM5	69
KEGG	hsa05132	Salmonella infection	80/2250	249/8135	0.06456	0.3655	0.3306	TUBB6/IL1B/MAPK11/IL18/NLRP3/RAC1/GAPDH/CYFIP1/TIRAP/TUBA1B/TUBA1C/FHOD1/SNX9/TNF/TLR4/AKT3/BAX/PLEKHM2/ANXA2/KLC1/ACTG1/TUBB/CSE1L/CYTH2/RIPK3/CYFIP2/RHOG/MAP2K3/MYL12B/DYNLRB1/MAPK12/TUBB4B/PAK1/PFN2/KLC3/RPS3/MAP2K6/FYCO1/DCTN5/ARPC1B/PAK3/M6PR/TCF7L2/TNFRSF10B/PTPRC/TUBB3/TLR2/S100A10/ARPC5/BAK1/IRAK1/RALA/PLEKHM1/TLR6/TUBB2A/JUN/KPNA3/TUBB4A/TAB1/NFKBIA/SNX33/ACTR3B/KLC4/MAP2K4/BIRC3/TRAF2/PIK3C3/ACTR1A/RIPK2/TNFSF10/CYTH1/TRAF6/ARF6/AHNAK/FOS/VPS39/CDC42/MAPK1/ARHGEF26/ACTB	80
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	34/2250	97/8135	0.06618	0.3684	0.3332	MARCKS/HCK/RAC1/GSN/AKT3/ASAP2/GAB2/FCGR1A/DOCK1/PAK1/ARPC1B/VAV2/PTPRC/PRKCA/VASP/CFL1/PIP5K1B/LAT/ARPC5/LIMK1/LIMK2/CRK/PRKCE/RAC2/ACTR3B/PRKCB/ARF6/SPHK2/NCF1/WASF2/PIP5K1A/CDC42/WAS/MAPK1	34
KEGG	hsa05214	Glioma	27/2250	75/8135	0.07031	0.385	0.3482	CDKN1A/GADD45G/E2F2/PDGFA/CAMK1/DDB2/E2F1/AKT3/BAX/GADD45A/MTOR/SHC4/CALML4/CAMK2A/IGF1R/PRKCA/BAK1/CDKN2A/CAMK2G/BRAF/CAMK2D/PRKCB/SHC2/MAPK1/CCND1/PDGFB/SHC1	27
KEGG	hsa05144	Malaria	19/2250	50/8135	0.07227	0.3869	0.3499	IL1B/IL18/ICAM1/IL10/TNF/TLR4/SDC2/TGFB3/THBS2/GYPC/HBA2/CCL2/SDC1/TLR2/LRP1/HBB/THBS4/TGFB1/KLRK1	19
KEGG	hsa00670	One carbon pool by folate	9/2250	20/8135	0.07297	0.3869	0.3499	MTHFD2/MTHFD1L/TYMS/MTHFS/DHFR/MTHFD1/MTFMT/MTR/AMT	9
KEGG	hsa04610	Complement and coagulation cascades	30/2250	85/8135	0.07446	0.3886	0.3515	PLAUR/PROS1/PROC/PLAU/SERPINE1/F5/ITGAX/PLAT/C1QB/F2RL2/CLU/CFD/CFHR4/A2M/VTN/BDKRB2/CD46/C3AR1/CR2/CFI/KLKB1/SERPING1/CFB/CFHR1/F3/F2R/C1QA/C1R/C6/TFPI	30
KEGG	hsa05330	Allograft rejection	15/2250	38/8135	0.07673	0.389	0.3519	CD86/IL10/CD80/TNF/HLA-DMA/HLA-G/FAS/HLA-DPA1/HLA-E/HLA-DRA/HLA-DMB/HLA-DQA2/IL4/HLA-DPB1/HLA-DRB1	15
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/2250	26/8135	0.07687	0.389	0.3519	PIGK/PIGH/DPM2/PIGQ/PIGO/PIGC/PIGW/PIGM/PIGA/PIGG/PIGT	11
KEGG	hsa05205	Proteoglycans in cancer	66/2250	205/8135	0.08342	0.4113	0.372	TWIST1/HBEGF/MAPK11/VEGFA/SDC4/CDKN1A/ITGA2/RAC1/PTPN6/PLAUR/HPSE/GPC1/MMP9/PTCH1/TNF/PPP1CB/ANK1/TLR4/CTTN/AKT3/PLAU/MTOR/WNT10B/ACTG1/STAT3/PDCD4/SRC/ARHGEF12/TIAM1/RPS6/CAMK2A/MAPK12/SDC2/IGF1R/PAK1/FZD6/SDC1/FAS/VAV2/EZR/PRKCA/TLR2/MRAS/VTN/WNT7A/FZD8/ELK1/ERBB2/CD44/CAMK2G/BRAF/CAMK2D/ESR1/FZD9/PRKCB/PRKACB/TIMP3/PPP1R12B/FZD5/TGFB1/CDC42/PPP1R12A/MAPK1/CCND1/RRAS2/ACTB	66
KEGG	hsa01524	Platinum drug resistance	26/2250	73/8135	0.08373	0.4113	0.372	CDKN1A/TOP2A/BIRC5/CASP9/MSH6/AKT3/BAX/PMAIP1/FAS/BID/GSTO1/MAP3K5/BAK1/CDKN2A/ERBB2/GSTM1/BCL2L1/BIRC3/GSTT1/MGST2/MGST3/XPA/ATM/MAPK1/ERCC1/BAD	26
KEGG	hsa00270	Cysteine and methionine metabolism	19/2250	51/8135	0.0864	0.4182	0.3783	BCAT1/IL4I1/LDHA/SDS/MPST/TST/LDHAL6B/SMS/CTH/MDH2/MRI1/BHMT/MTAP/ENOPH1/LACC1/GCLC/MTR/GSS/BHMT2	19
KEGG	hsa04630	JAK-STAT signaling pathway	53/2250	162/8135	0.08765	0.4182	0.3783	LIF/CSF2/IL21/CDKN1A/CSF2RB/IL10/PDGFA/PTPN6/CSF3R/CNTF/MCL1/SOCS2/IL2RA/AKT3/PIAS3/MTOR/IL2RB/STAT3/IL4R/PIM1/SOCS3/IL2RG/IL12RB2/STAM/IL9R/IL21R/IL15RA/PIAS1/CSF2RA/IL12RB1/IL27RA/OSM/STAT4/IL5RA/IL7R/PIAS2/IL22/BCL2L1/IL11RA/IL7/IL13/IL20/IFNGR1/PIAS4/IL4/STAT5A/STAT1/IL10RA/JAK3/CCND1/PDGFB/JAK1/IL23A	53
KEGG	hsa04530	Tight junction	55/2250	169/8135	0.09026	0.4204	0.3802	CD1E/RAC1/TUBA1B/TUBA1C/NF2/PPP2R1A/MYH10/ARHGEF18/CD1A/CTTN/TJP2/CD1C/ACTG1/SRC/TIAM1/MYL12B/ARHGEF2/MYL6/CD1B/RAB13/CD1D/AMOT/ARPC1B/PRKAB2/MAP3K5/EZR/MPP5/VASP/PRKCI/ACTN4/SCRIB/PPP2CA/ARPC5/PRKAG2/JUN/IGSF5/ERBB2/PRKCE/ACTR3B/PARD6G/MYL6B/RAPGEF2/CLDN7/MYH9/PRKACB/PARD6B/ARHGAP17/PARD6A/WHAMM/CDC42/WAS/CCND1/CLDN4/MAGI1/ACTB	55
KEGG	hsa00730	Thiamine metabolism	7/2250	15/8135	0.09108	0.4204	0.3802	TPK1/AK5/AK4/AK1/ACP1/NFS1/AK2	7
KEGG	hsa00061	Fatty acid biosynthesis	8/2250	18/8135	0.0952	0.4204	0.3802	MECR/MCAT/ACSL1/HSD17B8/ACSL4/OXSM/ACACB/FASN	8
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	14/2250	36/8135	0.09557	0.4204	0.3802	SIRT6/PNP/NAMPT/NADK/SIRT3/SIRT2/NT5E/NNT/SIRT7/NT5C2/NMNAT1/NMNAT3/SIRT1/ASPDH	14
KEGG	hsa03030	DNA replication	14/2250	36/8135	0.09557	0.4204	0.3802	MCM4/MCM5/FEN1/MCM2/RFC2/MCM7/POLD4/RNASEH2A/POLE/MCM3/DNA2/SSBP1/RNASEH2C/POLE2	14
KEGG	hsa00051	Fructose and mannose metabolism	13/2250	33/8135	0.09691	0.4204	0.3802	TPI1/HK1/PFKFB3/PFKP/MPI/HK2/ALDOC/PFKFB4/ENOSF1/PFKFB2/ALDOA/PFKL/ALDOB	13
KEGG	hsa03410	Base excision repair	13/2250	33/8135	0.09691	0.4204	0.3802	HMGB1/APEX2/MPG/NEIL3/FEN1/PARP2/POLD4/POLE/XRCC1/NEIL1/OGG1/MUTYH/POLE2	13
KEGG	hsa04390	Hippo signaling pathway	51/2250	157/8135	0.1024	0.4386	0.3967	TP73/BIRC5/YWHAH/YWHAE/NF2/PPP2R1A/YWHAZ/PPP1CB/TEAD3/SERPINE1/WNT10B/ACTG1/SMAD7/NKD1/LIMD1/DVL3/TGFB3/FZD6/WWTR1/AMOT/TCF7L2/MPP5/STK3/PRKCI/DVL1/SCRIB/PPP2CA/WNT7A/YWHAQ/GDF7/FZD8/FBXW11/YAP1/PARD6G/BIRC3/CTNNA1/BTRC/DLG5/SMAD1/FZD9/PARD6B/APC/AXIN2/PARD6A/FZD5/TEAD4/ID1/TGFB1/CCND1/DLG4/ACTB	51
KEGG	hsa03050	Proteasome	17/2250	46/8135	0.1079	0.456	0.4125	POMP/PSMD8/PSMD1/PSMD2/PSMF1/PSMD9/PSMA5/PSMB7/PSME2/PSMB5/PSMB4/PSMA3/PSMB1/PSMD7/PSMB3/PSMC5/PSMD11	17
KEGG	hsa01230	Biosynthesis of amino acids	26/2250	75/8135	0.1102	0.4601	0.4162	BCAT1/TPI1/GAPDH/ENO1/PGAM1/PFKP/SDS/PKM/ALDOC/GPT/ASNS/CTH/ENO3/ARG1/NAGS/CS/ACO1/PSPH/IDH3B/ALDOA/RPE/MTR/GPT2/PRPS1/PFKL/ALDOB	26
KEGG	hsa00920	Sulfur metabolism	5/2250	10/8135	0.1129	0.4656	0.4212	SUOX/ETHE1/MPST/TST/PAPSS2	5
KEGG	hsa05143	African trypanosomiasis	14/2250	37/8135	0.1162	0.4733	0.4281	IL1B/IL18/ICAM1/IL10/TNF/HBA2/FAS/PRKCA/IDO1/APOL1/HBB/PRKCB/GNAQ/PLCB1	14
KEGG	hsa05161	Hepatitis B	52/2250	162/8135	0.1184	0.4764	0.4309	EGR3/EGR2/MAPK11/IRF7/CDKN1A/BIRC5/CASP9/E2F2/CCNA2/TIRAP/MMP9/YWHAZ/DDB2/CREB3L2/TNF/E2F1/TLR4/AKT3/BAX/STAT3/SRC/MAP2K3/CDK2/MAPK12/TGFB3/ATF4/CCNE2/MAP2K6/FAS/BID/PRKCA/TLR2/IRAK1/YWHAQ/ELK1/JUN/STAT4/TAB1/NFKBIA/IRF3/MAP2K4/BRAF/STAT5A/PRKCB/TRAF6/STAT1/FOS/TGFB1/JAK3/MAPK1/BAD/JAK1	52
KEGG	hsa05220	Chronic myeloid leukemia	26/2250	76/8135	0.1252	0.498	0.4504	CDKN1A/GADD45G/E2F2/DDB2/E2F1/AKT3/BAX/GADD45A/GAB2/SHC4/TGFB3/BAK1/CDKN2A/NFKBIA/CRK/BCL2L1/BRAF/STAT5A/CTBP1/BCR/TGFB1/SHC2/MAPK1/CCND1/SHC1/BAD	26
KEGG	hsa05210	Colorectal cancer	29/2250	86/8135	0.1275	0.5011	0.4533	CDKN1A/BIRC5/CASP9/GADD45G/RAC1/DDB2/MSH6/AKT3/BAX/GADD45A/PMAIP1/MTOR/TGFB3/TCF7L2/RALGDS/BAK1/RALA/JUN/RAC2/BRAF/APC/AXIN2/RALB/FOS/TGFB1/MAPK1/CCND1/BAD/RAC3	29
KEGG	hsa04978	Mineral absorption	21/2250	60/8135	0.1299	0.5017	0.4538	VDR/MT1E/MT2A/HMOX1/HEPH/ATP1B1/MT1X/MT1H/ATP2B4/SLC26A6/FTL/MT1G/ATP1B3/FTH1/MT1A/HMOX2/CYBRD1/MT1B/MT1M/SLC40A1/MT1F	21
KEGG	hsa05134	Legionellosis	20/2250	57/8135	0.1343	0.5017	0.4538	IL1B/IL18/CASP9/HSPA2/NFKB2/TNF/HSPA1A/TLR4/VCP/BCL2L13/TLR2/CXCL2/EEF1A1/CXCL3/NFKBIA/EEF1A2/HSPA6/HSPA1L/RAB1A/RAB1B	20
KEGG	hsa04810	Regulation of actin cytoskeleton	68/2250	218/8135	0.1348	0.5017	0.4538	IQGAP3/ITGA2/ITGA3/PDGFA/RAC1/CYFIP1/MYH10/PPP1CB/GSN/ITGB8/ACTG1/MYLK2/ITGAX/CYFIP2/SRC/ARHGEF12/TIAM1/MYL12B/PAK4/DOCK1/PAK1/FGF9/PFN2/ARHGAP35/PIKFYVE/ARPC1B/PAK3/TMSB4Y/VAV2/EZR/ITGA1/CFL1/ITGA6/ACTN4/PIP5K1B/DIAPH3/MRAS/ARPC5/LIMK1/LIMK2/BDKRB2/INSRR/ITGAE/CRK/RAC2/ACTR3B/BRAF/MYH9/F2R/FGF22/ITGA2B/SSH2/FGF8/PIP4K2A/PPP1R12B/APC/WASF2/PIP4K2B/PIP5K1A/CDC42/PPP1R12A/MAPK1/PDGFB/SPATA13/RRAS2/PAK2/RAC3/ACTB	68
KEGG	hsa03440	Homologous recombination	15/2250	41/8135	0.1352	0.5017	0.4538	RBBP8/TOP3A/RAD54L/BRCA2/RAD51/TOPBP1/POLD4/BRCC3/XRCC3/EME1/SSBP1/RAD52/ATM/BARD1/RAD54B	15
KEGG	hsa05219	Bladder cancer	15/2250	41/8135	0.1352	0.5017	0.4538	HBEGF/VEGFA/CDKN1A/E2F2/TYMP/DAPK2/MMP9/E2F1/SRC/CDKN2A/ERBB2/BRAF/DAPK1/MAPK1/CCND1	15
KEGG	hsa05340	Primary immunodeficiency	14/2250	38/8135	0.1392	0.511	0.4622	RFXANK/BTK/IL2RG/PTPRC/AICDA/CD19/TNFRSF13B/TAP1/IL7R/CD3E/RFXAP/RAG2/JAK3/ZAP70	14
KEGG	hsa04657	IL-17 signaling pathway	31/2250	94/8135	0.1485	0.539	0.4875	IL1B/MAPK11/CSF2/FOSL1/CCL20/IL17A/MMP9/FOSB/TNF/CXCL10/IL17RE/MAPK12/CCL2/CCL17/TRAF4/CXCL2/CXCL3/JUN/IL17RC/NFKBIA/CEBPB/ELAVL1/IL13/TRAF2/S100A8/IL4/TRAF6/IL17C/CCL7/FOS/MAPK1	31
KEGG	hsa04520	Adherens junction	24/2250	71/8135	0.1518	0.5451	0.493	PTPRF/RAC1/PTPN6/PTPN1/ACTG1/SRC/SNAI1/IGF1R/TCF7L2/ACTN4/ERBB2/RAC2/PTPRM/CTNNA1/FER/INSR/ACP1/WASF2/CDC42/WAS/MAPK1/FYN/RAC3/ACTB	24
KEGG	hsa00230	Purine metabolism	41/2250	128/8135	0.155	0.5508	0.4982	ENTPD1/CANT1/PDE4A/RRM2B/ENTPD5/ADCY4/NUDT16/PFAS/AK5/PDE4D/RRM1/PDE4B/HPRT1/ENTPD2/ADCY6/AK3/PNP/NME4/ADPRM/AMPD2/NME3/ENPP4/AK4/ADCY3/APRT/IMPDH1/ENTPD4/RRM2/GUK1/AMPD3/LACC1/NT5E/PDE7B/AK1/ADCY9/PRPS1/PAPSS2/AK2/NT5C2/PDE6B/NME2	41
KEGG	hsa04664	Fc epsilon RI signaling pathway	23/2250	68/8135	0.1573	0.553	0.5002	MAPK11/CSF2/RAC1/ALOX5AP/TNF/FCER1A/AKT3/GAB2/MAP2K3/BTK/MAPK12/MAP2K6/VAV2/PRKCA/LAT/ALOX5/RAC2/MAP2K4/IL13/IL4/MAPK1/FYN/RAC3	23
KEGG	hsa00120	Primary bile acid biosynthesis	7/2250	17/8135	0.1636	0.5633	0.5095	HSD3B7/CH25H/CYP7B1/ACOX2/ACOT8/AMACR/CYP7A1	7
KEGG	hsa00450	Selenocompound metabolism	7/2250	17/8135	0.1636	0.5633	0.5095	CTH/SEPHS1/TXNRD3/MARS2/MTR/PAPSS2/TXNRD2	7
KEGG	hsa04146	Peroxisome	27/2250	82/8135	0.171	0.568	0.5137	MPV17/ABCD1/PMVK/ABCD2/FAR2/SLC27A2/HMGCL/EPHX2/PRDX5/ACSL1/ACOX2/ACOT8/AMACR/PEX2/PXMP4/PXMP2/ACSL4/PEX3/PEX5/PEX11A/GSTK1/NUDT19/PECR/PEX13/PEX1/PRDX1/DECR2	27
KEGG	hsa04722	Neurotrophin signaling pathway	38/2250	119/8135	0.1714	0.568	0.5137	MAPK11/TP73/SH2B2/NTRK2/NTRK1/RAC1/YWHAE/NFKBIE/AKT3/BAX/NFKBIB/SHC4/CALML4/CAMK2A/MAPK12/NTRK3/ATF4/IRAK3/MAP3K5/IRAK1/RAPGEF1/JUN/CAMK2G/NFKBIA/CRK/MAP3K3/BRAF/CAMK2D/RIPK2/MAPKAPK2/TRAF6/ARHGDIA/NTF3/CDC42/SHC2/MAPK1/SHC1/BAD	38
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	17/2250	49/8135	0.1718	0.568	0.5137	HK1/GPI/MPI/NANS/HK2/CYB5R2/GNE/GALK2/GNPDA1/GALK1/CYB5R1/HEXB/GALT/CYB5RL/UAP1L1/CMAS/NAGK	17
KEGG	hsa04672	Intestinal immune network for IgA production	17/2250	49/8135	0.1718	0.568	0.5137	CD86/IL10/CD80/HLA-DMA/IL15RA/HLA-DPA1/PIGR/HLA-DRA/AICDA/TNFRSF13B/HLA-DMB/HLA-DQA2/TNFSF13/IL4/HLA-DPB1/TGFB1/HLA-DRB1	17
KEGG	hsa04330	Notch signaling pathway	20/2250	59/8135	0.1755	0.5746	0.5198	NOTCH1/JAG2/TLE4/MAML1/TLE2/MAML2/DTX3L/DTX3/DVL3/KAT2A/RBPJ/JAG1/ATXN1/TLE3/DVL1/DTX4/DTX1/DTX2/CTBP1/DLL1	20
KEGG	hsa05224	Breast cancer	46/2250	147/8135	0.1831	0.5883	0.5322	NOTCH1/JAG2/CDKN1A/GADD45G/E2F2/DDB2/NFKB2/E2F1/BRCA2/AKT3/BAX/GADD45A/MTOR/WNT10B/SHC4/DVL3/IGF1R/FZD6/FGF9/JAG1/TCF7L2/DVL1/BAK1/SP1/WNT7A/FRAT1/FZD8/JUN/ERBB2/FLT4/BRAF/ESR1/FGF22/FZD9/LRP6/FGF8/APC/AXIN2/TNFSF11/FZD5/FOS/DLL1/SHC2/MAPK1/CCND1/SHC1	46
KEGG	hsa04971	Gastric acid secretion	25/2250	76/8135	0.1839	0.5883	0.5322	SLC4A2/ACTG1/MYLK2/ADCY4/CALML4/GNAS/CAMK2A/KCNJ2/ADCY6/ATP1B1/EZR/PRKCA/GNAI2/ATP1B3/CAMK2G/CA2/ADCY3/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1/KCNK2/ACTB	25
KEGG	hsa04940	Type I diabetes mellitus	15/2250	43/8135	0.185	0.5883	0.5322	IL1B/CD86/CD80/TNF/HLA-DMA/HLA-G/FAS/HLA-DPA1/HLA-E/HLA-DRA/LTA/HLA-DMB/HLA-DQA2/HLA-DPB1/HLA-DRB1	15
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	18/2250	53/8135	0.1892	0.5962	0.5393	VDR/CLTB/GNAS/ADCY6/ATP1B1/PRKCA/ATP2B4/AP2S1/KLK1/BDKRB2/ATP1B3/DNM1/ESR1/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1	18
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/2250	100/8135	0.1926	0.6005	0.5431	EGR1/IL1B/MAPK11/VEGFA/ICAM1/RAC1/PLCD3/TNF/CYBB/AKT3/BAX/SERPINE1/STAT3/PIM1/MAPK12/TGFB3/CCL2/FOXO1/COL4A6/PRKCA/JUN/PRKCE/F3/STAT5A/PRKCB/STAT1/PLCB1/TGFB1/CDC42/MAPK1/CCND1/VEGFC	32
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/2250	24/8135	0.1947	0.6005	0.5431	HS3ST3B1/HS3ST3A1/B3GAT3/B3GALT6/EXT1/EXTL2/HS6ST1/XYLT1/B4GALT7	9
KEGG	hsa05230	Central carbon metabolism in cancer	23/2250	70/8135	0.1982	0.6005	0.5431	SLC16A3/SLC1A5/NTRK1/SLC7A5/HK1/LDHA/SCO2/PGAM1/PFKP/SIRT6/HK2/AKT3/MTOR/LDHAL6B/GLS2/PKM/NTRK3/PDHB/FLT3/SIRT3/ERBB2/PFKL/MAPK1	23
KEGG	hsa04068	FoxO signaling pathway	41/2250	131/8135	0.1992	0.6005	0.5431	MAPK11/CDKN1A/GADD45G/KLF2/IL10/CDKN2B/CCNG2/BCL6/CCNB2/PLK4/SETD7/PLK2/AKT3/PLK1/GADD45A/HOMER2/STAT3/CCNB1/HOMER1/CDK2/MAPK12/IGF1R/TGFB3/SLC2A4/S1PR1/FOXO1/PRKAB2/PRKAG2/AGAP2/IL7R/RBL2/BRAF/SGK2/TNFSF10/INSR/ATM/RAG2/TGFB1/MAPK1/CCND1/SIRT1	41
KEGG	hsa04932	Non-alcoholic fatty liver disease	48/2250	155/8135	0.1996	0.6005	0.5431	IL1B/MAPK11/PPARG/RAC1/COX8A/TNF/AKT3/BAX/SOCS3/MAPK12/NDUFB11/COX6A1/UQCRC1/ATF4/NDUFB8/FAS/BID/PRKAB2/MAP3K5/ADIPOR2/NDUFS1/MAP3K11/ADIPOR1/DDIT3/RXRA/PRKAG2/NDUFS7/JUN/COX6B2/NDUFB10/NDUFC1/GSK3A/NDUFA9/COX4I1/UQCR11/TRAF2/EIF2AK3/ADIPOQ/ERN1/NDUFA12/INSR/FOS/NDUFA4/NDUFB2/TGFB1/CDC42/NDUFA13/MLX	48
KEGG	hsa04620	Toll-like receptor signaling pathway	33/2250	104/8135	0.2035	0.6068	0.5488	IL1B/MAPK11/IRF7/CD86/CCL3L3/CD80/RAC1/TLR8/TIRAP/SPP1/TNF/IRF5/TLR4/AKT3/CXCL10/MAP2K3/CCL3/MAPK12/MAP2K6/TOLLIP/CXCL9/TLR2/IRAK1/TLR6/JUN/TAB1/NFKBIA/IRF3/MAP2K4/TRAF6/STAT1/FOS/MAPK1	33
KEGG	hsa03020	RNA polymerase	12/2250	34/8135	0.2075	0.6132	0.5546	POLR2J3/POLR3H/POLR1D/POLR2I/POLR2C/ZNRD1/POLR2M/POLR2J/CRCP/POLR3GL/POLR2A/POLR1B	12
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/2250	15/8135	0.2127	0.6231	0.5636	GLB1/ST8SIA1/ST6GALNAC4/SLC33A1/HEXB/ST6GALNAC6	6
KEGG	hsa04710	Circadian rhythm	11/2250	31/8135	0.2158	0.6267	0.5669	CRY1/PER2/BHLHE40/RORC/PRKAB2/PRKAG2/FBXW11/ARNTL/BTRC/BHLHE41/PER3	11
KEGG	hsa04071	Sphingolipid signaling pathway	37/2250	119/8135	0.2275	0.651	0.5888	MAPK11/SGMS1/ABCC1/RAC1/SGMS2/PPP2R1A/TNF/FCER1A/AKT3/BAX/GAB2/MAPK12/SGPP1/PPP2R3C/S1PR1/BID/MAP3K5/PRKCA/PPP2CA/CTSD/BDKRB2/GNAI2/ACER1/PRKCE/RAC2/ACER2/ASAH2/TRAF2/PRKCB/GNAQ/PPP2R3B/SPHK2/PLCB1/CERS3/MAPK1/FYN/RAC3	37
KEGG	hsa04012	ErbB signaling pathway	27/2250	85/8135	0.2305	0.651	0.5888	HBEGF/CDKN1A/EIF4EBP1/AKT3/MTOR/SRC/SHC4/PAK4/CAMK2A/PAK1/PAK3/PRKCA/ELK1/JUN/ERBB2/CAMK2G/CRK/MAP2K4/BRAF/CAMK2D/STAT5A/PRKCB/SHC2/MAPK1/SHC1/BAD/PAK2	27
KEGG	hsa05213	Endometrial cancer	19/2250	58/8135	0.2314	0.651	0.5888	CDKN1A/CASP9/GADD45G/DDB2/AKT3/BAX/GADD45A/TCF7L2/BAK1/ELK1/ERBB2/CTNNA1/BRAF/APC/AXIN2/MAPK1/CCND1/BAD/ILK	19
KEGG	hsa04144	Endocytosis	75/2250	251/8135	0.2319	0.651	0.5888	RAB31/HSPA2/RAB11FIP1/TFRC/CLTB/PML/STAMBP/CHMP2B/CAPZB/HSPA1A/IL2RA/WIPF2/ASAP2/LDLR/IL2RB/ZFYVE27/SNF8/CYTH2/SRC/PSD4/HLA-G/ARRB1/IL2RG/STAM/IGF1R/ZFYVE9/CCR5/SH3GL1/ARPC1B/SMURF1/HLA-E/PRKCI/PIP5K1B/ARPC5/IQSEC1/AP2S1/ARAP1/HGS/AGAP5/CAPZA1/PSD3/ACAP1/ARAP3/RAB11FIP3/GBF1/AGAP2/DNAJC6/ACTR3B/SNX12/IST1/PARD6G/HSPA6/ARF4/RUFY2/DNM1/CHMP1A/EEA1/RAB11FIP5/RAB11FIP4/LDLRAP1/HSPA1L/GRK5/CYTH1/PARD6B/CHMP2A/TRAF6/ARF6/PARD6A/GRK6/EHD3/PIP5K1A/CDC42/IQSEC3/CHMP3/EHD4	75
KEGG	hsa03022	Basal transcription factors	15/2250	45/8135	0.2423	0.6672	0.6035	CDK7/TAF1L/TAF9B/TAF6L/TAF10/ERCC2/TAF11/GTF2H2/GTF2H1/TAF7/TAF6/MNAT1/GTF2H5/GTF2IRD1/GTF2I	15
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	28/2250	89/8135	0.2432	0.6672	0.6035	MAPK11/BATF/PDCD1/PTPN6/EML4/TIRAP/NFKBIE/TLR4/AKT3/MTOR/NFKBIB/STAT3/MAP2K3/MAPK12/MAP2K6/LAT/TLR2/JUN/NFKBIA/MAP3K3/CD3E/IFNGR1/TRAF6/STAT1/FOS/MAPK1/ZAP70/JAK1	28
KEGG	hsa05223	Non-small cell lung cancer	23/2250	72/8135	0.2437	0.6672	0.6035	CDKN1A/CASP9/GADD45G/E2F2/EML4/DDB2/E2F1/AKT3/BAX/GADD45A/STAT3/PRKCA/BAK1/CDKN2A/RXRA/ERBB2/BRAF/STAT5A/PRKCB/JAK3/MAPK1/CCND1/BAD	23
KEGG	hsa05414	Dilated cardiomyopathy	30/2250	96/8135	0.2465	0.6674	0.6037	ITGA2/ITGA3/TNF/SGCB/ITGB8/ACTG1/LMNA/ADCY4/GNAS/ATP2A1/TGFB3/ADCY6/ITGA1/CACNG3/ITGA6/TPM2/MYBPC3/CACNA2D2/MYH7/EMD/TNNC1/ADCY3/ITGA2B/PRKACB/ADCY9/TPM1/CACNB2/MYH6/TGFB1/ACTB	30
KEGG	hsa05332	Graft-versus-host disease	14/2250	42/8135	0.2528	0.6674	0.6037	IL1B/CD86/CD80/TNF/HLA-DMA/HLA-G/FAS/HLA-DPA1/HLA-E/HLA-DRA/HLA-DMB/HLA-DQA2/HLA-DPB1/HLA-DRB1	14
KEGG	hsa00531	Glycosaminoglycan degradation	7/2250	19/8135	0.2544	0.6674	0.6037	GLB1/HPSE/HYAL3/IDS/IDUA/HEXB/GUSB	7
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	7/2250	19/8135	0.2544	0.6674	0.6037	BCAT1/GPT/NAGS/CS/ACO1/IDH3B/GPT2	7
KEGG	hsa04912	GnRH signaling pathway	29/2250	93/8135	0.2555	0.6674	0.6037	EGR1/HBEGF/MAPK11/ADCY4/SRC/MAP2K3/CALML4/GNAS/MAP3K2/CAMK2A/MAPK12/ADCY6/ATF4/MAP2K6/PRKCA/ELK1/JUN/CAMK2G/ADCY3/MAP3K3/MAP2K4/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1/CDC42/MAPK1	29
KEGG	hsa04611	Platelet activation	38/2250	124/8135	0.2558	0.6674	0.6037	RASGRP2/MAPK11/ITGA2/PPP1CB/AKT3/ACTG1/MYLK2/ADCY4/SRC/ARHGEF12/P2RX1/MYL12B/BTK/GNAS/MAPK12/APBB1IP/ADCY6/PIK3R5/ARHGAP35/VASP/PRKCI/FERMT3/SNAP23/GNAI2/TBXAS1/ADCY3/TBXA2R/F2R/ITGA2B/PRKACB/P2RY1/GNAQ/ADCY9/PLCB1/PPP1R12A/MAPK1/FYN/ACTB	38
KEGG	hsa04392	Hippo signaling pathway - multiple species	10/2250	29/8135	0.2632	0.6782	0.6134	RASSF2/NF2/TEAD3/DCHS1/LIMD1/PAK1/WWTR1/STK3/YAP1/TEAD4	10
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	58/2250	194/8135	0.264	0.6782	0.6134	GNG4/MAPK11/IRF7/VEGFA/CD86/CSF2/CDKN1A/ICAM1/CASP9/E2F2/HCK/RAC1/CCR1/GNG10/ZFP36/E2F1/AKT3/BAX/MAP1LC3A/MTOR/STAT3/SRC/CCR4/HLA-G/CALML4/MAPK12/GNG7/UBB/CCR5/MAP2K6/PIK3R5/RPS27A/PREX1/FAS/TCF7L2/BID/HLA-E/UBA52/MICA/BAK1/CXCL2/CXCL3/JUN/NFKBIA/CCR8/GNB4/IRF3/MAP2K4/TRAF2/PIK3C3/IFNGR1/MAPKAPK2/STAT1/FOS/MAPK1/CCND1/PDGFB/JAK1	58
KEGG	hsa04625	C-type lectin receptor signaling pathway	32/2250	104/8135	0.2698	0.6879	0.6222	EGR3/EGR2/IL1B/MAPK11/RELB/NLRP3/IL10/BCL3/CCL22/CLEC7A/KSR1/NFKB2/TNF/AKT3/LSP1/CARD9/SRC/ARHGEF12/CALML4/MAPK12/PAK1/CCL17/CYLD/MRAS/CLEC4D/JUN/NFKBIA/MAPKAPK2/STAT1/MAPK1/RRAS2/IL23A	32
KEGG	hsa05162	Measles	42/2250	139/8135	0.2765	0.6997	0.6329	IL1B/IRF7/TP73/CASP9/HSPA2/OAS2/MX1/HSPA1A/IL2RA/TLR4/AKT3/BAX/IL2RB/NFKBIB/STAT3/IL2RG/CDK2/CCNE2/FAS/BID/TLR2/BAK1/IRAK1/CD46/JUN/NFKBIA/BCL2L1/IRF3/CD3E/OAS1/HSPA6/EIF3H/EIF2AK3/STAT5A/HSPA1L/TRAF6/STAT1/FOS/JAK3/CCND1/BAD/JAK1	42
KEGG	hsa01200	Carbon metabolism	35/2250	115/8135	0.2825	0.7094	0.6416	TPI1/GAPDH/HK1/ENO1/PGAM1/PFKP/GPI/HK2/SDS/PKM/GLDC/ALDOC/OGDH/PDHB/GPT/MDH2/DLST/DLAT/ENO3/CS/ACO1/PSPH/GLUD1/IDH3B/ALDOA/ME3/ACSS1/RPE/PCCB/GPT2/PRPS1/AMT/PFKL/ALDOB/PGD	35
KEGG	hsa05164	Influenza A	51/2250	171/8135	0.287	0.7155	0.6471	IL1B/IRF7/IL18/NLRP3/ICAM1/CASP9/OAS2/PML/KPNA2/MX1/TNF/NUP98/TLR4/AKT3/BAX/CXCL10/TRIM25/HLA-DMA/ACTG1/NFKBIB/RSAD2/FDPS/SOCS3/CCL2/CALCOCO2/FAS/BID/TNFRSF10B/HLA-DPA1/PRKCA/HLA-DRA/BAK1/VDAC1/SLC25A5/NFKBIA/RAE1/HLA-DMB/IRF3/HLA-DQA2/OAS1/IFNGR1/TNFSF10/PRKCB/HLA-DPB1/STAT1/SLC25A4/MAPK1/HLA-DRB1/JAK1/NXF3/ACTB	51
KEGG	hsa04360	Axon guidance	54/2250	182/8135	0.2952	0.7285	0.6589	ABLIM1/FES/RAC1/EPHB1/PLXNB2/CDK5/PTCH1/SEMA4C/PLXNB1/SEMA7A/SRGAP2/TRPC1/RGMA/SEMA3G/SRC/EPHB4/ARHGEF12/MYL12B/SEMA6C/PAK4/CAMK2A/PLXNA1/PAK1/SEMA6B/EFNB1/PAK3/PRKCA/L1CAM/CFL1/LIMK1/LIMK2/GNAI2/GDF7/SRGAP3/CAMK2G/RAC2/SEMA3B/PARD6G/SEMA5B/CAMK2D/ABLIM2/SSH2/PARD6B/SEMA4D/LRRC4C/PARD6A/SEMA5A/CDC42/MAPK1/TRPC5/FYN/PAK2/ILK/RAC3	54
KEGG	hsa04540	Gap junction	27/2250	88/8135	0.298	0.7285	0.6589	TUBB6/CDK1/PDGFA/TUBA1B/TUBA1C/TUBB/ADCY4/SRC/GNAS/HTR2A/MAP3K2/TUBB4B/ADCY6/PRKCA/TUBB3/DRD1/GNAI2/TUBB2A/TUBB4A/ADCY3/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1/MAPK1/PDGFB	27
KEGG	hsa00260	Glycine, serine and threonine metabolism	13/2250	40/8135	0.2988	0.7285	0.6589	PGAM1/GAMT/SDS/GLDC/SARDH/CTH/GCAT/BHMT/GRHPR/PSPH/GNMT/ALDH7A1/AMT	13
KEGG	hsa04972	Pancreatic secretion	31/2250	102/8135	0.301	0.7285	0.659	RAC1/SLC4A2/TRPC1/CELA2B/ADCY4/SLC12A2/GNAS/PLA2G12A/ATP2A1/RAB3D/ADCY6/CCKAR/CCK/ATP1B1/PRKCA/ATP2B4/ATP1B3/CA2/CLCA2/ADCY3/PLA2G2A/PLA2G2C/CPB1/PRKCB/CTRB1/GNAQ/ADCY9/PLA2G5/CLCA1/PLCB1/AMY2A	31
KEGG	hsa00620	Pyruvate metabolism	15/2250	47/8135	0.3055	0.7326	0.6626	LDHA/LDHAL6B/PKM/PDHB/ALDH2/MDH2/DLAT/GRHPR/ME3/ACACB/ACSS1/ALDH7A1/ALDH9A1/ACYP1/AKR1A1	15
KEGG	hsa04612	Antigen processing and presentation	24/2250	78/8135	0.3072	0.7326	0.6626	HSPA2/IFI30/HSPA5/TNF/HSPA1A/HLA-DMA/RFXANK/HLA-G/CD74/CTSB/HLA-DPA1/HLA-E/HLA-DRA/TAP1/HLA-DMB/HLA-DQA2/HSPA6/PSME2/CANX/HSPA1L/RFXAP/HLA-DPB1/HLA-DRB1/NFYB	24
KEGG	hsa01250	Biosynthesis of nucleotide sugars	12/2250	37/8135	0.3131	0.7326	0.6626	HK1/GPI/MPI/NANS/HK2/GNE/GALK2/GALK1/GALT/UAP1L1/CMAS/NAGK	12
KEGG	hsa04934	Cushing syndrome	46/2250	155/8135	0.3133	0.7326	0.6626	NR4A1/CDKN1A/E2F2/CDKN2B/CREB3L2/E2F1/ARMC5/CDKN2C/LDLR/WNT10B/ADCY4/GNAS/CDK2/CAMK2A/DVL3/FZD6/ADCY6/ATF4/CCNE2/RASD1/TCF7L2/DVL1/CDKN2A/SP1/GNAI2/WNT7A/FZD8/CAMK2G/ADCY3/BRAF/HSD3B2/CAMK2D/WDR5B/FZD9/PRKACB/GNAQ/ADCY9/APC/AXIN2/PBX1/FZD5/CYP11A1/PLCB1/MAPK1/CCND1/KCNK2	46
KEGG	hsa04140	Autophagy - animal	42/2250	141/8135	0.3136	0.7326	0.6626	SQSTM1/TP53INP2/DAPK2/MTMR3/HMGB1/AKT3/MAP1LC3A/MTOR/ATG9A/CFLAR/IGF1R/SNAP29/AMBRA1/CTSB/DDIT4/MRAS/ULK1/PPP2CA/TANK/CTSD/ATG2B/DEPTOR/BCL2L1/UVRAG/MTMR14/DAPK1/RAB39B/LAMP1/PIK3C3/EIF2AK3/ERN1/ATG4B/PRKACB/TRAF6/PIK3R4/RAB1A/RRAGB/ATG7/MAPK1/MLST8/BAD/RRAS2	42
KEGG	hsa04662	B cell receptor signaling pathway	25/2250	82/8135	0.3207	0.7433	0.6723	RAC1/PTPN6/NFKBIE/AKT3/LILRA2/NFKBIB/DAPP1/LILRB4/BTK/CD79B/VAV2/LILRB2/IFITM1/CD19/JUN/CR2/NFKBIA/RAC2/LILRA6/LILRA5/CARD11/PRKCB/FOS/MAPK1/RAC3	25
KEGG	hsa05150	Staphylococcus aureus infection	29/2250	96/8135	0.3227	0.7433	0.6723	ICAM1/FPR1/IL10/FPR3/HLA-DMA/FCGR1A/C1QB/CFD/HLA-DPA1/HLA-DRA/FPR2/C3AR1/FCAR/HLA-DMB/CFI/KRT19/HLA-DQA2/KRT20/CFB/KRT31/C1QA/C1R/DEFA1B/HLA-DPB1/DEFA4/KRT40/KRT12/HLA-DRB1/PTAFR	29
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/2250	79/8135	0.3329	0.7615	0.6888	VEGFA/PDGFA/EIF4EBP1/AKT3/BAX/MTOR/STAT3/SRC/SHC4/RPS6/AXL/IGF1R/PRKCA/ERBB2/BCL2L1/BRAF/EIF4E2/PRKCB/SHC2/MAPK1/PDGFB/SHC1/BAD/JAK1	24
KEGG	hsa05020	Prion disease	79/2250	273/8135	0.3373	0.7642	0.6912	TUBB6/EGR1/PPIF/IL1B/MAPK11/NOTCH1/CASP9/HSPA2/RAC1/NCF4/TUBA1B/TUBA1C/COX8A/HSPA5/CREB3L2/TNF/HSPA1A/CYBB/BAX/KLC1/TUBB/C1QB/PSMD8/STIP1/MAPK12/NDUFB11/PSMD1/TUBB4B/PSMD2/COX6A1/UQCRC1/ATF4/KLC3/NDUFB8/TUBB3/NDUFS1/PSMD9/PSMA5/DDIT3/NDUFS7/TUBB2A/VDAC1/PSMB7/TUBB4A/SLC25A5/COX6B2/NDUFB10/RAC2/GRIN3B/CYBA/NDUFC1/KLC4/HSPA6/NDUFA9/COX4I1/UQCR11/EIF2AK3/PSMB5/PRNP/C1QA/NDUFA12/HSPA1L/PRKACB/PSMB4/PSMA3/C6/SLC25A4/NCF1/NDUFA4/NDUFB2/PSMB1/PSMD7/NDUFA13/PSMB3/MAPK1/PSMC5/BAD/FYN/PSMD11	79
KEGG	hsa05012	Parkinson disease	77/2250	266/8135	0.3386	0.7642	0.6912	TUBB6/PPIF/CASP9/ADORA2A/SLC39A1/TUBA1B/SLC39A7/TUBA1C/COX8A/HSPA5/BAX/KLC1/TUBB/PSMD8/CALML4/GNAS/CAMK2A/UBB/NDUFB11/PSMD1/TUBB4B/PSMD2/UBA7/COX6A1/UQCRC1/ATF4/KLC3/NDUFB8/RPS27A/SLC39A11/MAP3K5/PINK1/UBE2G2/UBA52/TUBB3/NDUFS1/DRD1/PSMD9/PSMA5/DDIT3/GNAI2/NDUFS7/TUBB2A/VDAC1/PARK7/PSMB7/TUBB4A/SLC25A5/COX6B2/CAMK2G/NDUFB10/BCL2L1/NDUFC1/KLC4/NDUFA9/COX4I1/UQCR11/EIF2AK3/CAMK2D/PSMB5/ERN1/NDUFA12/PRKACB/PSMB4/PSMA3/SLC25A4/NDUFA4/SLC39A10/NDUFB2/PSMB1/PSMD7/NDUFA13/PSMB3/UCHL1/PSMC5/PSMD11/DUSP1	77
KEGG	hsa04920	Adipocytokine signaling pathway	21/2250	69/8135	0.3449	0.7642	0.6913	TNF/NFKBIE/AKT3/MTOR/NFKBIB/STAT3/SOCS3/ACSL1/SLC2A4/PRKAB2/ADIPOR2/ADIPOR1/RXRA/PRKAG2/NFKBIA/ACSL4/TRAF2/ADIPOQ/CPT1A/TNFRSF1B/ACACB	21
KEGG	hsa05211	Renal cell carcinoma	21/2250	69/8135	0.3449	0.7642	0.6913	VEGFA/CDKN1A/RAC1/AKT3/TFE3/PAK4/TGFB3/PAK1/PAK3/RAPGEF1/JUN/CRK/EPAS1/BRAF/ARNT2/TGFB1/CDC42/MAPK1/PDGFB/BAD/PAK2	21
KEGG	hsa05215	Prostate cancer	29/2250	97/8135	0.3462	0.7642	0.6913	CDKN1A/CASP9/E2F2/PDGFA/MMP9/CREB3L2/E2F1/AKT3/PLAU/MTOR/IL1R2/PLAT/ETV5/CDK2/IGF1R/ATF4/CCNE2/SPINT1/FOXO1/TCF7L2/INSRR/ERBB2/NFKBIA/BRAF/MAPK1/CCND1/PDGFB/BAD/KLK3	29
KEGG	hsa04141	Protein processing in endoplasmic reticulum	50/2250	171/8135	0.3478	0.7642	0.6913	HSPA2/SEC13/DNAJA1/SEC24D/HSPA5/HSPA1A/DERL1/BAX/UBXN6/CAPN1/SYVN1/VCP/TXNDC5/DNAJB12/SEC61A2/HERPUD1/ATF4/PDIA4/UBXN1/NPLOC4/MAP3K5/UBE2G2/BCAP31/CRYAA/RAD23B/BAK1/SEC61B/DDIT3/PRKCSH/RAD23A/EDEM2/LMAN2/HSPA6/CKAP4/UBQLN2/BAG2/TRAF2/EIF2AK3/RRBP1/ERN1/NSFL1C/CANX/HSPA1L/GANAB/MBTPS2/PPP1R15A/MAN1A1/DNAJB2/MOGS/SSR2	50
KEGG	hsa05017	Spinocerebellar ataxia	42/2250	143/8135	0.3523	0.7666	0.6934	PPIF/AKT3/MTOR/CIC/PSMD8/ATP2A1/PSMD1/PSMD2/RBPJ/AMBRA1/MAP3K5/ATXN1/PRKCA/ULK1/SP1/PSMD9/PSMA5/BEAN1/VDAC1/PSMB7/SLC25A5/ATG2B/GRIN3B/ATXN8OS/TRAF2/PIK3C3/PSMB5/ERN1/KCND3/PRKCB/PSMB4/GNAQ/PSMA3/PIK3R4/SLC25A4/PLCB1/PSMB1/PSMD7/PSMB3/OMA1/PSMC5/PSMD11	42
KEGG	hsa00770	Pantothenate and CoA biosynthesis	7/2250	21/8135	0.356	0.7666	0.6934	BCAT1/VNN2/ALDH2/DPYD/AASDHPPT/VNN1/PANK1	7
KEGG	hsa00600	Sphingolipid metabolism	16/2250	52/8135	0.3567	0.7666	0.6934	SGMS1/NEU4/GLB1/SGMS2/KDSR/NEU1/SGPP1/GBA/ACER1/ACER2/ASAH2/NEU3/GALC/SPHK2/HEXB/CERS3	16
KEGG	hsa04370	VEGF signaling pathway	18/2250	59/8135	0.358	0.7666	0.6934	MAPK11/VEGFA/CASP9/RAC1/SH2D2A/AKT3/SRC/MAPK12/PRKCA/RAC2/MAPKAPK2/PRKCB/SPHK2/CDC42/SHC2/MAPK1/BAD/RAC3	18
KEGG	hsa05163	Human cytomegalovirus infection	65/2250	225/8135	0.3623	0.7708	0.6972	GNG4/IL1B/MAPK11/VEGFA/CDKN1A/CASP9/IL1R1/E2F2/CCL3L3/RAC1/CCR1/GNG10/EIF4EBP1/CREB3L2/TNF/E2F1/AKT3/BAX/MTOR/STAT3/ADCY4/SRC/ARHGEF12/HLA-G/CALML4/GNAS/CCL3/PTGER4/MAPK12/GNG7/ADCY6/ATF4/CCR5/MAP2K6/CCL2/FAS/BID/PRKCA/HLA-E/BAK1/CDKN2A/SP1/TAP1/GNAI2/ELK1/NFKBIA/CRK/RAC2/PTGER2/ADCY3/GNB4/IRF3/PTGER1/TRAF2/PRKCB/PRKACB/GNAQ/ADCY9/AKAP13/IL10RA/PLCB1/MAPK1/CCND1/RAC3/JAK1	65
KEGG	hsa05014	Amyotrophic lateral sclerosis	104/2250	364/8135	0.3648	0.7711	0.6975	TUBB6/MAPK11/CASP9/SQSTM1/RAC1/SEC13/TUBA1B/TUBA1C/COX8A/CHMP2B/HSPA5/TNF/NUP98/DERL1/BAX/MAP1LC3A/MTOR/GPX1/KLC1/ACTG1/TUBB/MAP2K3/PSMD8/VCP/HNRNPA3/MAPK12/NDUFB11/PSMD1/TUBB4B/PSMD2/COX6A1/UQCRC1/ATF4/PFN2/KLC3/NUP153/MAP2K6/AMBRA1/NDUFB8/DCTN5/BID/MAP3K5/PINK1/TUBB3/ULK1/NDUFS1/PSMD9/TANK/NUP88/PSMA5/DDIT3/NDUFS7/TUBB2A/VDAC1/PSMB7/TUBB4A/COX6B2/POM121C/NDUFB10/NUP205/ATG2B/RAE1/BCL2L1/NUP50/NDUFC1/KLC4/NDUFA9/COX4I1/UBQLN2/DNAI2/RAB39B/UQCR11/TRAF2/PIK3C3/EIF2AK3/POM121L2/PSMB5/ERN1/ACTR1A/TNFRSF1B/NDUFA12/GLE1/PSMB4/PSMA3/PIK3R4/RAB1A/NUP93/CCS/NEFL/NUP35/NDUFA4/NDUFB2/PSMB1/PSMD7/NDUFA13/PSMB3/NUP62/PSMC5/SEH1L/BAD/DNAH6/NXF3/PSMD11/ACTB	104
KEGG	hsa05203	Viral carcinogenesis	59/2250	204/8135	0.3672	0.7714	0.6978	EGR3/EGR2/IRF7/CDK1/CDKN1A/CDKN2B/SRF/RAC1/CDC20/CCNA2/ATP6V0D1/YWHAH/YWHAE/YWHAZ/NFKB2/CREB3L2/GSN/BAX/PMAIP1/STAT3/SRC/CCR4/PKM/HLA-G/CDK2/KAT2A/RBPJ/ATF4/CCNE2/CCR5/DNAJA3/HLA-E/ACTN4/SCRIB/BAK1/CDKN2A/YWHAQ/JUN/UBE3A/CHEK1/NFKBIA/TRAF1/GTF2H2/CCR8/RBL2/IRF3/GTF2H1/TRAF2/MAPKAPK2/STAT5A/PRKACB/HDAC9/CDC42/JAK3/MAPK1/CCND1/HDAC10/BAD/JAK1	59
KEGG	hsa05100	Bacterial invasion of epithelial cells	23/2250	77/8135	0.3727	0.7749	0.7009	RAC1/CLTB/CTTN/ACTG1/SRC/SHC4/RHOG/DOCK1/ARPC1B/ARPC5/CRK/ACTR3B/CTNNA1/CD2AP/DNM1/MAD2L2/WASF2/CDC42/SHC2/SHC1/ARHGEF26/ILK/ACTB	23
KEGG	hsa03250	Viral life cycle - HIV-1	19/2250	63/8135	0.3735	0.7749	0.7009	FURIN/APOBEC3H/SERINC3/MX1/SMARCB1/APOBEC3B/BST2/KAT2A/NUP153/CCR5/CCNT2/HGS/MAP1S/SAMHD1/MLLT3/ELL/CPSF6/MAP1A/TRIM5	19
KEGG	hsa04914	Progesterone-mediated oocyte maturation	30/2250	102/8135	0.3814	0.7816	0.707	PKMYT1/MAPK11/CDK1/AURKA/CCNA2/BUB1/CCNB2/CDC25A/AKT3/PLK1/CDC25C/ADCY4/CCNB1/CDK2/MAPK12/IGF1R/ADCY6/GNAI2/ANAPC11/ADCY3/ANAPC1/BRAF/CPEB1/MAD2L2/PRKACB/ADCY9/ANAPC13/CDC25B/MAPK1/CDC16	30
KEGG	hsa05146	Amoebiasis	30/2250	102/8135	0.3814	0.7816	0.707	IL1B/CD1E/CSF2/GNA15/IL10/IL1R1/SERPINB6/TNF/CD1A/TLR4/CD1C/IL1R2/GNAS/CD1B/TGFB3/CD1D/COL4A6/PRKCA/ACTN4/TLR2/ARG1/CXCL2/CXCL3/PRKCB/PRKACB/GNAQ/PLCB1/TGFB1/LAMA5/PRDX1	30
KEGG	hsa04152	AMPK signaling pathway	35/2250	120/8135	0.3886	0.7849	0.7099	PPARG/CCNA2/PFKFB3/PFKP/PPP2R1A/EIF4EBP1/CREB3L2/AKT3/MTOR/CRTC2/SCD/IGF1R/PFKFB4/SLC2A4/PPP2R3C/FOXO1/PRKAB2/STRADB/ADIPOR2/ULK1/PFKFB2/PPP2CA/ADIPOR1/PRKAG2/ELAVL1/RAB2A/ADIPOQ/CPT1A/ACACB/FASN/INSR/PPP2R3B/PFKL/CCND1/SIRT1	35
KEGG	hsa05320	Autoimmune thyroid disease	16/2250	53/8135	0.3897	0.7849	0.7099	CD86/IL10/CD80/HLA-DMA/CTLA4/HLA-G/FAS/HLA-DPA1/HLA-E/HLA-DRA/TSHR/HLA-DMB/HLA-DQA2/IL4/HLA-DPB1/HLA-DRB1	16
KEGG	hsa04621	NOD-like receptor signaling pathway	53/2250	184/8135	0.3901	0.7849	0.7099	IL1B/MAPK11/IRF7/TXNIP/IL18/NLRP3/OAS2/GBP2/YWHAE/TNF/CYBB/TLR4/MAP1LC3A/NFKBIB/CARD9/RIPK3/TP53BP1/TRIP6/MAPK12/CTSB/CCL2/CASR/NAMPT/CARD6/ANTXR2/NOD2/TANK/DHX33/CXCL2/CXCL3/VDAC1/BRCC3/JUN/TAB1/NFKBIA/BCL2L1/CYBA/IRF3/BIRC3/OAS1/IFI16/TRAF2/RIPK2/DEFA1B/TRAF6/DEFA4/STAT1/CARD8/GBP4/PLCB1/MAPK1/P2RX7/JAK1	53
KEGG	hsa04150	mTOR signaling pathway	45/2250	156/8135	0.3987	0.7975	0.7213	SLC7A5/SEC13/EIF4EBP1/TNF/AKT3/MTOR/WNT10B/TTI1/MAPKAP1/RPS6/DVL3/ATP6V1E1/IGF1R/FZD6/SLC3A2/WDR24/PRKCA/STRADB/DDIT4/ATP6V1A/DVL1/ULK1/WNT7A/FZD8/SLC38A9/DEPTOR/BRAF/ATP6V1G1/NPRL3/EIF4E2/FZD9/LAMTOR4/LRP6/PRKCB/LAMTOR2/INSR/ATP6V1E2/FZD5/RRAGB/MAPK1/SESN2/SEH1L/MLST8/LPIN1/NPRL2	45
KEGG	hsa04936	Alcoholic liver disease	41/2250	142/8135	0.4034	0.8019	0.7253	IL1B/MAPK11/IL17A/TIRAP/TNF/TLR4/AKT3/SCD/C1QB/MAP2K3/MAPK12/ALDH2/MAP2K6/FOXO1/FAS/TCF7L2/PRKAB2/MAP3K5/ADIPOR2/IRAK1/ADIPOR1/CXCL2/PRKAG2/CXCL3/C3AR1/IL17RC/TAB1/NFKBIA/IRF3/MAP2K4/ADIPOQ/CPT1A/C1QA/ACACB/FASN/TRAF6/ALDH7A1/ALDH9A1/CCND1/LPIN1/SIRT1	41
KEGG	hsa00340	Histidine metabolism	7/2250	22/8135	0.4083	0.8023	0.7257	CARNS1/AMDHD1/ALDH2/ALDH3A1/ALDH3B1/ALDH7A1/ALDH9A1	7
KEGG	hsa01240	Biosynthesis of cofactors	44/2250	153/8135	0.4097	0.8023	0.7257	BCAT1/MTHFD2/MTHFD1L/VKORC1L1/MPI/DHODH/CPOX/TPK1/CMPK2/VKORC1/MMAB/GGH/AK5/PDXP/ALDH2/AK3/NQO1/DHFR/NME4/LIAS/NADK/MTHFD1/NME3/AK4/IDO1/MOCS1/OXSM/PPOX/GCLC/AK1/CMPK1/CTPS2/GUSB/NFS1/SPR/GSS/PANK1/AK2/NMNAT1/NMNAT3/DHRS3/AKR1A1/NME2/ASPDH	44
KEGG	hsa04919	Thyroid hormone signaling pathway	35/2250	121/8135	0.4107	0.8023	0.7257	NOTCH1/CASP9/PLCD3/PFKP/THRA/AKT3/MTOR/ACTG1/SRC/ATP2A1/MED4/KAT2A/FOXO1/ATP1B1/PRKCA/PFKFB2/MED24/RXRA/MYH7/ATP1B3/MED12L/SLC16A10/ESR1/PRKCB/PRKACB/STAT1/MED12/PFKL/MYH6/PLCB1/MAPK1/CCND1/NCOR1/BAD/ACTB	35
KEGG	hsa04014	Ras signaling pathway	66/2250	232/8135	0.4174	0.8106	0.7332	RASGRP2/GNG4/VEGFA/NTRK2/CSF1R/NTRK1/PDGFA/RAC1/KSR1/GNG10/CSF1/AKT3/GAB2/SHC4/TIAM1/CALML4/PAK4/PLA2G12A/GNG7/RAPGEF5/IGF1R/PAK1/FGF9/FLT3/RASGRF2/PAK3/RASAL2/KSR2/PRKCA/RASA3/LAT/MRAS/RALGDS/RALA/FLT1/RASGRP4/ELK1/RASA4/RAC2/GNB4/BCL2L1/FLT4/RASAL1/PLA2G2A/FGF22/PLA2G2C/PRKCB/PRKACB/INSR/ARF6/FGF8/RALB/NTF3/PLA2G5/CDC42/SHC2/MAPK1/PDGFB/ZAP70/SHC1/VEGFC/BAD/RRAS2/RALBP1/PAK2/RAC3	66
KEGG	hsa04911	Insulin secretion	25/2250	86/8135	0.4246	0.8198	0.7415	CREB3L2/ADCY4/GNAS/CAMK2A/ADCY6/ATF4/CCKAR/CCK/ATP1B1/KCNMB1/PRKCA/TRPM4/KCNN4/KCNU1/ATP1B3/CAMK2G/ADCY3/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/FFAR1/PLCB1/PDX1	25
KEGG	hsa04660	T cell receptor signaling pathway	30/2250	104/8135	0.4295	0.8228	0.7442	MAPK11/CSF2/IL10/PDCD1/PTPN6/TNF/NFKBIE/AKT3/NFKBIB/CTLA4/PAK4/MAPK12/PAK1/GRAP2/PAK3/VAV2/PTPRC/LAT/JUN/NFKBIA/ITK/CD3E/CARD11/IL4/FOS/CDC42/MAPK1/ZAP70/FYN/PAK2	30
KEGG	hsa04130	SNARE interactions in vesicular transport	10/2250	33/8135	0.4311	0.8228	0.7442	STX11/STX5/SNAP29/STX1B/STX19/SNAP23/VAMP3/STX16/VTI1B/STX2	10
KEGG	hsa05410	Hypertrophic cardiomyopathy	26/2250	90/8135	0.4361	0.8276	0.7486	ITGA2/ITGA3/TNF/SGCB/ITGB8/ACTG1/LMNA/ATP2A1/TGFB3/PRKAB2/ITGA1/CACNG3/ITGA6/TPM2/MYBPC3/CACNA2D2/PRKAG2/MYH7/EMD/TNNC1/ITGA2B/TPM1/CACNB2/MYH6/TGFB1/ACTB	26
KEGG	hsa05133	Pertussis	22/2250	76/8135	0.4435	0.8369	0.757	IL1B/MAPK11/NLRP3/IL10/TIRAP/TNF/TLR4/C1QB/CALML4/MAPK12/CFL1/IRAK1/GNAI2/JUN/IRF3/SERPING1/C1QA/C1R/TRAF6/FOS/MAPK1/IL23A	22
KEGG	hsa04910	Insulin signaling pathway	39/2250	137/8135	0.448	0.84	0.7598	SH2B2/PTPRF/TRIP10/HK1/SOCS2/EIF4EBP1/PPP1CB/HK2/AKT3/PTPN1/MTOR/SOCS3/SHC4/RPS6/CALML4/PYGM/SLC2A4/FOXO1/PRKAB2/PRKCI/FLOT1/PPP1R3E/PRKAG2/RAPGEF1/ELK1/MKNK1/CRK/PHKG2/BRAF/EIF4E2/ACACB/PRKACB/FASN/INSR/SHC2/MAPK1/SHC1/BAD/PPP1R3B	39
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	11/2250	37/8135	0.4502	0.84	0.7598	IL4I1/RIMKLB/GLS2/ABAT/GPT/ASNS/NAT8L/GLUD1/GPT2/ALDH5A1/NIT2	11
KEGG	hsa00030	Pentose phosphate pathway	9/2250	30/8135	0.455	0.8443	0.7636	PFKP/GPI/ALDOC/ALDOA/RPE/PRPS1/PFKL/ALDOB/PGD	9
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	28/2250	98/8135	0.4578	0.8447	0.764	IL1B/MAPK11/IL1R1/NTRK1/PPP1CB/ADCY4/SRC/MAP2K3/CALML4/GNAS/HTR2A/PTGER4/CAMK2A/MAPK12/ADCY6/MAP2K6/PRKCA/BDKRB2/CAMK2G/PRKCE/PTGER2/ADCY3/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1	28
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	20/2250	70/8135	0.4772	0.8758	0.7922	HBEGF/MAPK11/RAC1/ATP6V0D1/ATP6V0B/SRC/MAPK12/ATP6V1E1/PAK1/ATP6V0C/ATP6V1A/CXCL2/CXCL3/JUN/IGSF5/NFKBIA/MAP2K4/ATP6V1G1/ATP6V1E2/CDC42	20
KEGG	hsa05217	Basal cell carcinoma	18/2250	63/8135	0.4832	0.881	0.7969	CDKN1A/GADD45G/PTCH1/DDB2/BAX/GADD45A/WNT10B/DVL3/FZD6/TCF7L2/DVL1/BAK1/WNT7A/FZD8/FZD9/APC/AXIN2/FZD5	18
KEGG	hsa05131	Shigellosis	69/2250	247/8135	0.4854	0.881	0.7969	IL1B/MAPK11/IL18/CSF2/NLRP3/SQSTM1/IL1R1/RAC1/HK1/U2AF1/TIFA/PLCD3/TNF/HK2/TLR4/CTTN/AKT3/BAX/MAP1LC3A/MTOR/CAPN1/ACTG1/NFKBIB/CYTH2/SRC/MYL12B/ARHGEF2/MAPK12/DOCK1/UBB/PFN2/UBE2N/CALCOCO2/RPS27A/FOXO1/ARPC1B/ACTN4/UBA52/ARPC5/VDAC1/JUN/FBXW11/TAB1/U2AF1L4/CD44/NFKBIA/CRK/PRKCE/ACTR3B/BCL2L1/IRF3/GSK3A/BTRC/TRAF2/PIK3C3/RIPK2/CYTH1/TRAF6/ARF6/PIK3R4/WASF2/ATM/RRAGB/PLCB1/CDC42/GLMN/MAPK1/ILK/ACTB	69
KEGG	hsa05160	Hepatitis C	44/2250	157/8135	0.4893	0.8835	0.7991	IRF7/CDKN1A/CASP9/E2F2/IFIT1/YWHAH/OAS2/YWHAE/PPP2R1A/YWHAZ/MX1/TNF/E2F1/AKT3/BAX/CXCL10/LDLR/STAT3/RSAD2/SOCS3/CFLAR/CDK2/FAS/BID/PIAS1/PPP2CA/BAK1/RXRA/YWHAQ/NFKBIA/IRF3/OAS1/BRAF/CLDN7/TRAF2/EIF2AK3/TRAF6/STAT1/EIF3E/MAPK1/CCND1/CLDN4/BAD/JAK1	44
KEGG	hsa00410	beta-Alanine metabolism	9/2250	31/8135	0.4998	0.8975	0.8118	SMOX/CARNS1/ABAT/ALDH2/DPYD/ALDH3A1/ALDH3B1/ALDH7A1/ALDH9A1	9
KEGG	hsa03450	Non-homologous end-joining	4/2250	13/8135	0.5044	0.9008	0.8148	FEN1/XRCC6/POLM/NHEJ1	4
KEGG	hsa04926	Relaxin signaling pathway	36/2250	129/8135	0.5084	0.9033	0.817	GNG4/MAPK11/VEGFA/GNA15/MMP9/GNG10/CREB3L2/AKT3/ADCY4/SRC/SHC4/ARRB1/GNAS/MAPK12/GNG7/ADCY6/ATF4/COL4A6/PRKCA/GNAI2/JUN/NFKBIA/ADCY3/GNB4/MAP2K4/INSL3/PRKACB/ADCY9/ACTA2/FOS/PLCB1/TGFB1/SHC2/MAPK1/SHC1/VEGFC	36
KEGG	hsa04930	Type II diabetes mellitus	13/2250	46/8135	0.5195	0.9181	0.8304	HK1/SOCS2/TNF/HK2/MTOR/SOCS3/PKM/SLC2A4/PRKCE/ADIPOQ/INSR/MAPK1/PDX1	13
KEGG	hsa04935	Growth hormone synthesis, secretion and action	33/2250	119/8135	0.528	0.9283	0.8396	MAPK11/SOCS2/CREB3L2/AKT3/MTOR/STAT3/ADCY4/SOCS3/SHC4/MAP2K3/GNAS/MAPK12/ADCY6/ATF4/MAP2K6/IGFBP3/PRKCA/GNAI2/CRK/ADCY3/MAP2K4/GHRL/STAT5A/PRKCB/PRKACB/GNAQ/ADCY9/STAT1/FOS/PLCB1/SHC2/MAPK1/SHC1	33
KEGG	hsa04916	Melanogenesis	28/2250	101/8135	0.5323	0.9308	0.8419	CREB3L2/WNT10B/ADCY4/CALML4/GNAS/CAMK2A/DVL3/FZD6/ADCY6/TCF7L2/PRKCA/DVL1/GNAI2/WNT7A/FZD8/ASIP/CAMK2G/ADCY3/CAMK2D/FZD9/PRKCB/PRKACB/GNAQ/ADCY9/FZD5/PLCB1/TYRP1/MAPK1	28
KEGG	hsa05218	Melanoma	20/2250	72/8135	0.5359	0.9322	0.8432	CDKN1A/GADD45G/E2F2/PDGFA/DDB2/E2F1/AKT3/BAX/GADD45A/IGF1R/FGF9/BAK1/CDKN2A/BRAF/FGF22/FGF8/MAPK1/CCND1/PDGFB/BAD	20
KEGG	hsa04136	Autophagy - other	9/2250	32/8135	0.5435	0.9322	0.8432	MTOR/ATG9A/PPP2CA/ATG2B/PIK3C3/ATG4B/PIK3R4/ATG7/MLST8	9
KEGG	hsa04215	Apoptosis - multiple species	9/2250	32/8135	0.5435	0.9322	0.8432	BIRC5/CASP9/BAX/PMAIP1/BID/BAK1/BCL2L1/BIRC3/BIRC7	9
KEGG	hsa04915	Estrogen signaling pathway	38/2250	138/8135	0.5456	0.9322	0.8432	HBEGF/HSPA2/MMP9/CREB3L2/HSPA1A/AKT3/ADCY4/SRC/SHC4/CALML4/GNAS/ADCY6/ATF4/FKBP5/SP1/CTSD/GNAI2/EBAG9/JUN/ADCY3/KRT19/TFF1/HSPA6/KRT20/KRT31/ESR1/HSPA1L/PRKACB/GNAQ/ADCY9/KRT40/FOS/PLCB1/SHC2/RARA/KRT12/MAPK1/SHC1	38
KEGG	hsa05226	Gastric cancer	41/2250	149/8135	0.5471	0.9322	0.8432	CDKN1A/GADD45G/E2F2/CDKN2B/DDB2/E2F1/AKT3/BAX/GADD45A/MTOR/WNT10B/SHC4/CDK2/DVL3/TGFB3/FZD6/FGF9/CCNE2/TCF7L2/DVL1/BAK1/RXRA/WNT7A/FRAT1/FZD8/ERBB2/CTNNA1/BRAF/FGF22/FZD9/LRP6/FGF8/APC/AXIN2/FZD5/TGFB1/SHC2/MAPK1/CCND1/REG4/SHC1	41
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	36/2250	131/8135	0.5518	0.9355	0.8462	CSF2/ICAM1/RAC1/PTPN6/ULBP2/TNF/RAET1E/SHC4/HLA-G/SH2D1A/PAK1/FAS/BID/TNFRSF10B/VAV2/PRKCA/HLA-E/LAT/MICA/ICAM2/CD48/RAC2/BRAF/IFNGR1/ULBP1/TNFSF10/TYROBP/PRKCB/HCST/SHC2/MAPK1/KLRK1/ZAP70/SHC1/FYN/RAC3	36
KEGG	hsa00983	Drug metabolism - other enzymes	22/2250	80/8135	0.5553	0.9368	0.8473	TYMP/TK1/RRM2B/RRM1/NAT1/HPRT1/NME4/GSTO1/NME3/GSTM1/DPYD/MPO/IMPDH1/NAT2/RRM2/GSTT1/MGST2/CMPK1/UCK2/GUSB/MGST3/NME2	22
KEGG	hsa04213	Longevity regulating pathway - multiple species	17/2250	62/8135	0.5651	0.9459	0.8556	HSPA2/HSPA1A/AKT3/MTOR/ADCY4/IGF1R/ADCY6/FOXO1/PRKAB2/PRKAG2/ADCY3/HSPA6/HSPA1L/PRKACB/INSR/ADCY9/SIRT1	17
KEGG	hsa04371	Apelin signaling pathway	38/2250	139/8135	0.5664	0.9459	0.8556	EGR1/GNG4/KLF2/SPP1/GNG10/AKT3/MAP1LC3A/SERPINE1/MTOR/MYLK2/ADCY4/PLAT/RPS6/CALML4/GNG7/ADCY6/PIK3R5/JAG1/PRKAB2/MEF2D/MRAS/GNAI2/PRKAG2/MEF2B/PRKCE/ADCY3/GNB4/PIK3C3/PRKACB/GNAQ/ADCY9/SPHK2/PIK3R4/ACTA2/PLCB1/MAPK1/CCND1/RRAS2	38
KEGG	hsa04670	Leukocyte transendothelial migration	31/2250	114/8135	0.5802	0.9641	0.8721	MAPK11/ICAM1/RAC1/NCF4/MMP9/CYBB/ACTG1/MYL12B/MAPK12/ARHGAP35/ARHGAP5/VAV2/EZR/PRKCA/VASP/ACTN4/TXK/THY1/GNAI2/RAC2/CD99L2/CYBA/ITK/CTNNA1/CLDN7/PRKCB/NCF1/CDC42/CDH5/CLDN4/ACTB	31
KEGG	hsa04917	Prolactin signaling pathway	19/2250	70/8135	0.5839	0.9655	0.8733	MAPK11/SOCS2/AKT3/STAT3/SRC/SOCS3/SHC4/MAPK12/ESR1/CSN2/STAT5A/GALT/STAT1/TNFSF11/FOS/SHC2/MAPK1/CCND1/SHC1	19
KEGG	hsa00220	Arginine biosynthesis	6/2250	22/8135	0.5965	0.9798	0.8862	GLS2/GPT/ARG1/NAGS/GLUD1/GPT2	6
KEGG	hsa04211	Longevity regulating pathway	24/2250	89/8135	0.5984	0.9798	0.8862	PPARG/EIF4EBP1/CREB3L2/AKT3/BAX/MTOR/ADCY4/IGF1R/ADCY6/ATF4/FOXO1/PRKAB2/ADIPOR2/ULK1/ADIPOR1/PRKAG2/ADCY3/ADIPOQ/EIF4E2/PRKACB/INSR/ADCY9/SESN2/SIRT1	24
KEGG	hsa03015	mRNA surveillance pathway	26/2250	97/8135	0.6133	0.9826	0.8888	PPP2R1A/PPP1CB/SMG5/PABPC1L/RNPS1/PELO/MSI2/UPF1/PPP2R3C/MAGOHB/PPP2CA/UPF3A/MAGOH/CPSF1/PNN/SMG6/GLE1/CPSF6/PPP2R3B/GSPT1/WDR82/DDX19A/PAPOLA/NCBP2/CSTF3/NXF3	26
KEGG	hsa00020	Citrate cycle (TCA cycle)	8/2250	30/8135	0.6169	0.9826	0.8888	OGDH/PDHB/MDH2/DLST/DLAT/CS/ACO1/IDH3B	8
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	8/2250	30/8135	0.6169	0.9826	0.8888	GLDC/MDH2/GRHPR/CS/ACO1/ACSS1/PCCB/AMT	8
KEGG	hsa00565	Ether lipid metabolism	13/2250	49/8135	0.6237	0.9826	0.8888	PLD4/GDPD3/PLA2G12A/LPCAT2/TMEM86B/GDPD1/TMEM189/LPCAT4/PLA2G2A/PLA2G2C/PLA2G5/PAFAH1B3/PLB1	13
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2250	11/8135	0.624	0.9826	0.8888	VKORC1L1/VKORC1/NQO1	3
KEGG	hsa03018	RNA degradation	21/2250	79/8135	0.6272	0.9826	0.8888	ENO1/PFKP/NUDT16/XRN2/HSPA9/PABPC1L/DCPS/CNOT3/ZCCHC7/PAN3/ENO3/EDC4/TOB2/EXOSC2/CNOT7/PFKL/TTC37/DIS3L/BTG3/EXOSC9/LSM2	21
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	129/2250	476/8135	0.6281	0.9826	0.8888	TUBB6/PPIF/IL1B/MAPK11/CASP9/SQSTM1/RAC1/TUBA1B/CDK5/HIP1/TUBA1C/COX8A/CHMP2B/HSPA5/TNF/CSF1/CYBB/DERL1/BAX/MAP1LC3A/MTOR/CAPN1/GPX1/WNT10B/KLC1/TUBB/MAP2K3/PSMD8/VCP/CALML4/ATP2A1/CAMK2A/MAPK12/DVL3/UBB/NDUFB11/PSMD1/TUBB4B/PSMD2/UBA7/FZD6/COX6A1/UQCRC1/ATF4/KLC3/MAP2K6/HTT/AMBRA1/NDUFB8/DCTN5/RPS27A/FAS/BID/MAP3K5/PINK1/UBE2G2/ATXN1/PRKCA/UBA52/TUBB3/DVL1/ULK1/NDUFS1/BAK1/PSMD9/TANK/PSMA5/DDIT3/WNT7A/NDUFS7/FRAT1/TUBB2A/FZD8/VDAC1/PARK7/PSMB7/TUBB4A/SLC25A5/COX6B2/CAMK2G/NDUFB10/ATG2B/BCL2L1/NDUFC1/KLC4/NDUFA9/BRAF/COX4I1/DNAI2/RAB39B/UQCR11/TRAF2/PIK3C3/EIF2AK3/CAMK2D/PSMB5/ERN1/PRNP/ACTR1A/TNFRSF1B/NDUFA12/FZD9/LRP6/PRKCB/PSMB4/GNAQ/PSMA3/PIK3R4/RAB1A/APC/SLC25A4/AXIN2/CCS/NEFL/FZD5/NDUFA4/PLCB1/NDUFB2/PSMB1/PSMD7/NDUFA13/PSMB3/UCHL1/MAPK1/PSMC5/BAD/DLG4/DNAH6/PSMD11	129
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2250	15/8135	0.6307	0.9826	0.8888	NAGA/GBGT1/ST8SIA1/HEXB	4
KEGG	hsa00564	Glycerophospholipid metabolism	26/2250	98/8135	0.6368	0.9826	0.8888	MBOAT7/DGKD/PLD4/AGPAT3/AGPAT2/DGKZ/PLA2G12A/LPCAT2/LPCAT3/ADPRM/LPCAT4/PLA2G15/PNPLA6/PLA2G2A/PLA2G2C/LCLAT1/PTDSS1/PLA2G5/TAZ/GPCPD1/GPAT2/PLB1/MBOAT1/LPIN1/CRLS1/PGS1	26
KEGG	hsa04925	Aldosterone synthesis and secretion	26/2250	98/8135	0.6368	0.9826	0.8888	NR4A1/CAMK1/CREB3L2/LDLR/ADCY4/CALML4/GNAS/CAMK2A/ADCY6/ATF4/ATP1B1/PRKD3/PRKCA/ATP2B4/ATP1B3/CAMK2G/PRKCE/ADCY3/HSD3B2/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/CYP11A1/PLCB1	26
KEGG	hsa03060	Protein export	6/2250	23/8135	0.6445	0.9826	0.8888	HSPA5/SEC61A2/SEC11C/SEC61B/IMMP1L/SPCS3	6
KEGG	hsa03430	Mismatch repair	6/2250	23/8135	0.6445	0.9826	0.8888	EXO1/MSH6/RFC2/POLD4/SSBP1/MLH3	6
KEGG	hsa04614	Renin-angiotensin system	6/2250	23/8135	0.6445	0.9826	0.8888	ANPEP/CTSA/PRCP/KLK1/PREP/LNPEP	6
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	6/2250	23/8135	0.6445	0.9826	0.8888	GLS2/ATP1B1/ATP1B3/CA2/GLUD1/CA4	6
KEGG	hsa00561	Glycerolipid metabolism	16/2250	61/8135	0.6463	0.9826	0.8888	GK/DGKD/AGPAT3/AGPAT2/DGKZ/ALDH2/MOGAT1/DGAT2/LCLAT1/ALDH7A1/ALDH9A1/AGK/GPAT2/MBOAT1/AKR1A1/LPIN1	16
KEGG	hsa00062	Fatty acid elongation	7/2250	27/8135	0.6512	0.9826	0.8888	TECR/THEM5/MECR/PPT1/ELOVL7/ELOVL1/HADHB	7
KEGG	hsa04966	Collecting duct acid secretion	7/2250	27/8135	0.6512	0.9826	0.8888	ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1A/CA2/ATP6V1G1/ATP6V1E2	7
KEGG	hsa04927	Cortisol synthesis and secretion	17/2250	65/8135	0.6531	0.9826	0.8888	NR4A1/CREB3L2/LDLR/ADCY4/GNAS/ADCY6/ATF4/SP1/ADCY3/HSD3B2/PRKACB/GNAQ/ADCY9/PBX1/CYP11A1/PLCB1/KCNK2	17
KEGG	hsa00052	Galactose metabolism	8/2250	31/8135	0.6576	0.985	0.8909	HK1/GLB1/PFKP/HK2/GALK1/GALM/GALT/PFKL	8
KEGG	hsa03460	Fanconi anemia pathway	14/2250	54/8135	0.6624	0.9877	0.8934	TOP3A/FANCI/FANCG/BRCA2/RAD51/RMI2/FANCC/FANCF/EME1/ATR/POLN/WDR48/FAN1/ERCC1	14
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/2250	16/8135	0.6854	1	0.9045	GGT1/FMO2/GGT7/FMO5	4
KEGG	hsa04977	Vitamin digestion and absorption	6/2250	24/8135	0.6889	1	0.9045	ABCC1/TCN2/CUBN/MMACHC/LMBRD1/PLB1	6
KEGG	hsa04931	Insulin resistance	28/2250	108/8135	0.692	1	0.9045	PTPRF/CREB3L2/TNF/PPP1CB/AKT3/PTPN1/MTOR/CRTC2/STAT3/SOCS3/PPARGC1B/SLC27A2/PYGM/SLC2A4/FOXO1/PRKAB2/PPP1R3E/PRKAG2/NFKBIA/PRKCE/CPT1A/SLC27A4/ACACB/PRKCB/INSR/MLX/PPP1R3B/TRIB3	28
KEGG	hsa00650	Butanoate metabolism	7/2250	28/8135	0.6921	1	0.9045	ACSM3/ABAT/HMGCL/OXCT1/OXCT2/BDH2/ALDH5A1	7
KEGG	hsa04970	Salivary secretion	24/2250	93/8135	0.6933	1	0.9045	SLC4A2/ADCY4/CST5/SLC12A2/CALML4/GNAS/CST3/LYZ/ADCY6/ATP1B1/PRKCA/KCNN4/ATP2B4/ATP1B3/ADCY3/HTN3/PRKCB/PRKACB/GNAQ/ADCY9/CST1/PLCB1/CST2/AMY2A	24
KEGG	hsa04070	Phosphatidylinositol signaling system	25/2250	97/8135	0.6982	1	0.9045	DGKD/PLCD3/MTMR3/DGKZ/INPP4A/CALML4/PIKFYVE/IMPA2/PRKCA/PIP5K1B/PI4K2A/ITPKC/PPIP5K1/INPP1/MTMR14/PIK3C3/IP6K1/PRKCB/PIP4K2A/IP6K2/IPPK/PIP4K2B/PIP5K1A/PLCB1/IP6K3	25
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	39/2250	150/8135	0.7057	1	0.9045	MAPK11/PPP2R1A/CREB3L2/PPP1CB/AKT3/ADCY4/SCN1B/CALML4/GNAS/ATP2A1/CAMK2A/MAPK12/ADCY6/ATF4/PIK3R5/PPP2R3C/ATP1B1/PRKCA/CACNG3/TPM2/PPP2CA/ATP2B4/CACNA2D2/GNAI2/MYH7/ATP1B3/CAMK2G/TNNC1/ADCY3/CAMK2D/PRKACB/GNAQ/ADCY9/PPP2R3B/TPM1/CACNB2/MYH6/PLCB1/MAPK1	39
KEGG	hsa00280	Valine, leucine and isoleucine degradation	12/2250	48/8135	0.7115	1	0.9045	BCAT1/IL4I1/ABAT/HMGCL/ALDH2/OXCT1/OXCT2/HIBADH/PCCB/ALDH7A1/ALDH9A1/HADHB	12
KEGG	hsa03320	PPAR signaling pathway	19/2250	75/8135	0.7152	1	0.9045	PPARG/GK/OLR1/SCD/FABP5/SLC27A2/ACSL1/ACOX2/RXRA/PLIN2/ACSL4/ADIPOQ/CPT1A/ME3/SLC27A4/AQP7/PPARD/CYP7A1/ILK	19
KEGG	hsa04918	Thyroid hormone synthesis	19/2250	75/8135	0.7152	1	0.9045	HSPA5/CREB3L2/GPX1/ADCY4/GNAS/ADCY6/ATF4/PDIA4/ATP1B1/PRKCA/ATP1B3/TSHR/ADCY3/CANX/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1	19
KEGG	hsa03040	Spliceosome	38/2250	147/8135	0.7185	1	0.9045	HSPA2/U2AF1/PRPF40B/CHERP/RBM22/PQBP1/HSPA1A/PPIH/EFTUD2/HNRNPA3/SRSF4/SNRPC/CCDC12/SNRNP40/MAGOHB/SART1/PRPF31/THOC3/SF3B4/SF3B2/RBM17/U2AF1L4/DDX42/DHX38/HSPA6/SNRPB/PRPF19/MAGOH/PRPF3/CDC5L/HSPA1L/SNRPD2/CDC40/NCBP2/PHF5A/SYF2/PRPF38B/LSM2	38
KEGG	hsa05231	Choline metabolism in cancer	25/2250	98/8135	0.7193	1	0.9045	PDGFA/RAC1/DGKD/EIF4EBP1/AKT3/MTOR/DGKZ/SLC22A3/PRKCA/PIP5K1B/RALGDS/SP1/JUN/RAC2/PRKCB/WASF2/FOS/PIP5K1A/GPCPD1/WAS/SLC22A4/MAPK1/PDGFB/RAC3/SLC44A1	25
KEGG	hsa04340	Hedgehog signaling pathway	14/2250	56/8135	0.7194	1	0.9045	EVC/IQCE/PTCH1/GPR161/ARRB1/SMURF1/EFCAB7/MGRN1/FBXW11/EVC2/BTRC/PRKACB/CSNK1G2/CCND1	14
KEGG	hsa04217	Necroptosis	41/2250	159/8135	0.7305	1	0.9045	IL1B/NLRP3/SQSTM1/CHMP2B/HMGB1/TNF/CYBB/TLR4/BAX/CAPN1/STAT3/RIPK3/CFLAR/PYGM/CAMK2A/FAS/BID/TNFRSF10B/CYLD/FTL/VDAC1/STAT4/SLC25A5/CAMK2G/FTH1/GLUD1/BIRC3/TRAF2/IFNGR1/CAMK2D/CHMP1A/TNFSF10/STAT5A/CHMP2A/STAT1/SLC25A4/JAK3/SPATA2/PGAM5/CHMP3/JAK1	41
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	9/2250	37/8135	0.7327	1	0.9045	NR3C2/SFN/ATP1B1/PRKCA/ATP1B3/PRKCB/INSR/MAPK1/SLC9A3R2	9
KEGG	hsa00910	Nitrogen metabolism	4/2250	17/8135	0.7341	1	0.9045	CA2/GLUD1/CA4/CA13	4
KEGG	hsa05165	Human papillomavirus infection	87/2250	331/8135	0.7351	1	0.9045	VEGFA/NOTCH1/CDKN1A/ITGA2/ITGA3/ISG15/CCNA2/ATP6V0D1/COL9A2/SPP1/COL6A2/PPP2R1A/EIF4EBP1/MAML1/MX1/CREB3L2/TNF/E2F1/AKT3/BAX/ATP6V0B/MTOR/ITGB8/WNT10B/MAML2/PKM/HLA-G/GNAS/CDK2/PTGER4/DVL3/ATP6V1E1/FZD6/OASL/THBS2/RBPJ/CCNE2/COL6A1/ATP6V0C/PPP2R3C/FOXO1/JAG1/COL4A6/FAS/TCF7L2/BCAP31/MPP5/ITGA1/HLA-E/PRKCI/ATP6V1A/ITGA6/DVL1/VTN/SCRIB/PPP2CA/TUBG2/BAK1/WNT7A/FZD8/UBE3A/RBL2/IRF3/PARD6G/ATP6V1G1/TUBG1/FZD9/ITGA2B/PRKACB/ATR/PARD6B/PPP2R3B/APC/STAT1/ATP6V1E2/AXIN2/PARD6A/FZD5/ATM/THBS4/CDC42/MAPK1/CCND1/LAMA5/BAD/MAGI1/JAK1	87
KEGG	hsa02010	ABC transporters	11/2250	45/8135	0.7373	1	0.9045	ABCC1/ABCG1/ABCD1/ABCD2/ABCA1/TAP1/ABCC6/ABCB4/ABCA5/ABCA3/ABCB8	11
KEGG	hsa05030	Cocaine addiction	12/2250	49/8135	0.7399	1	0.9045	GPSM1/CDK5/FOSB/CREB3L2/GNAS/ATF4/DRD1/GNAI2/JUN/GRIN3B/PRKACB/DLG4	12
KEGG	hsa01212	Fatty acid metabolism	14/2250	57/8135	0.7455	1	0.9045	TECR/MECR/SCD/MCAT/PPT1/ACSL1/HSD17B8/ELOVL7/ELOVL1/ACSL4/CPT1A/OXSM/FASN/HADHB	14
KEGG	hsa04922	Glucagon signaling pathway	27/2250	107/8135	0.7467	1	0.9045	LDHA/PGAM1/PFKP/CREB3L2/AKT3/CRTC2/LDHAL6B/PKM/CALML4/GNAS/PYGM/CAMK2A/PDHB/ATF4/FOXO1/PRKAB2/PRKAG2/CAMK2G/PHKG2/CAMK2D/CPT1A/ACACB/PRKACB/GNAQ/PFKL/PLCB1/SIRT1	27
KEGG	hsa04514	Cell adhesion molecules	38/2250	149/8135	0.7513	1	0.9045	CD86/SDC4/CD276/ICAM1/PTPRF/CD80/PDCD1/ITGB8/HLA-DMA/CTLA4/HLA-G/TIGIT/SDC2/SDC1/HLA-DPA1/PTPRC/HLA-E/L1CAM/ITGA6/HLA-DRA/CD58/CADM1/ICAM2/PTPRM/HLA-DMB/CD99L2/PDCD1LG2/HLA-DQA2/NEGR1/CLDN7/NLGN4Y/CD34/CD6/HLA-DPB1/LRRC4C/CDH5/HLA-DRB1/CLDN4	38
KEGG	hsa04270	Vascular smooth muscle contraction	34/2250	134/8135	0.7537	1	0.9045	ADORA2A/PPP1R14A/MYH10/PPP1CB/MYLK2/ADCY4/ARHGEF12/ACTG2/CALML4/GNAS/PLA2G12A/MYL6/ADCY6/KCNMB1/PRKCA/KCNU1/PRKCE/ADCY3/MYL6B/BRAF/ADM/MYH9/PLA2G2A/PLA2G2C/PRKCB/PRKACB/GNAQ/ADCY9/PPP1R12B/ACTA2/PLA2G5/PLCB1/PPP1R12A/MAPK1	34
KEGG	hsa05031	Amphetamine addiction	17/2250	69/8135	0.7542	1	0.9045	FOSB/CREB3L2/PPP1CB/CALML4/GNAS/CAMK2A/ATF4/PRKCA/DRD1/JUN/CAMK2G/GRIN3B/CAMK2D/PRKCB/PRKACB/FOS/SIRT1	17
KEGG	hsa04020	Calcium signaling pathway	62/2250	240/8135	0.761	1	0.9045	PPIF/VEGFA/GNA15/ADORA2A/NTRK2/NTRK1/PDGFA/ORAI2/CAMK1/PLCD3/ASPH/MYLK2/ADCY4/P2RX1/CALML4/GNAS/HTR2A/ATP2A1/CAMK2A/NTRK3/CYSLTR1/P2RX6/FGF9/CCKAR/TPCN1/PRKCA/ORAI3/DRD1/ATP2B4/FLT1/BDKRB2/NTSR1/ITPKC/VDAC1/SLC25A5/ERBB2/CAMK2G/TNNC1/TACR2/ADCY3/TBXA2R/FLT4/PHKG2/PTGER1/HTR6/CAMK2D/P2RX5/F2R/FGF22/PRKCB/PRKACB/GNAQ/ADCY9/FGF8/SPHK2/SLC25A4/PLCB1/LTB4R2/PDGFB/PTAFR/P2RX7/VEGFC	62
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/2250	22/8135	0.7701	1	0.9045	PMVK/FDPS/RCE1/FNTB/IDI2	5
KEGG	hsa04713	Circadian entrainment	24/2250	97/8135	0.7742	1	0.9045	GNG4/GNG10/ADCY4/CALML4/GNAS/CAMK2A/GNG7/ADCY6/PER2/RASD1/PRKCA/GNAI2/CAMK2G/ADCY3/GNB4/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/PER3/FOS/PLCB1/MAPK1	24
KEGG	hsa04725	Cholinergic synapse	28/2250	113/8135	0.785	1	0.9045	GNG4/GNG10/CREB3L2/AKT3/ADCY4/CAMK2A/GNG7/KCNJ2/ADCY6/ATF4/PIK3R5/KCNQ5/PRKCA/GNAI2/KCNQ3/CAMK2G/ADCY3/GNB4/CAMK2D/CHRNA3/PRKCB/PRKACB/GNAQ/ADCY9/FOS/PLCB1/MAPK1/FYN	28
KEGG	hsa05016	Huntington disease	79/2250	306/8135	0.7869	1	0.9045	TUBB6/PPIF/PPARG/CASP9/RCOR1/TUBA1B/HIP1/TUBA1C/CLTB/COX8A/CREB3L2/BAX/MTOR/GPX1/KLC1/TUBB/TGM2/PSMD8/NDUFB11/PSMD1/TUBB4B/PSMD2/COX6A1/UQCRC1/KLC3/HTT/AMBRA1/NDUFB8/DCTN5/POLR2J3/MAP3K5/TUBB3/ULK1/NDUFS1/SP1/PSMD9/AP2S1/PSMA5/NDUFS7/POLR2I/TUBB2A/VDAC1/PSMB7/TUBB4A/SLC25A5/COX6B2/NDUFB10/ATG2B/NDUFC1/POLR2C/KLC4/NDUFA9/COX4I1/DNAI2/UQCR11/TRAF2/PIK3C3/PSMB5/ERN1/ACTR1A/NDUFA12/PSMB4/GNAQ/POLR2J/PSMA3/PIK3R4/SLC25A4/NDUFA4/PLCB1/NDUFB2/PSMB1/POLR2A/PSMD7/NDUFA13/PSMB3/PSMC5/DLG4/DNAH6/PSMD11	79
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/2250	14/8135	0.7889	1	0.9045	B3GNT2/ST3GAL3/B4GALT4	3
KEGG	hsa00514	Other types of O-glycan biosynthesis	11/2250	47/8135	0.7907	1	0.9045	GALNT2/GALNT12/POMT2/EOGT/GALNT1/ST3GAL3/POGLUT1/GALNT10/XXYLT1/PLOD3/C1GALT1	11
KEGG	hsa00330	Arginine and proline metabolism	12/2250	51/8135	0.7911	1	0.9045	P4HA2/LAP3/SMOX/GAMT/CARNS1/SMS/ALDH2/SAT1/ARG1/CKB/ALDH7A1/ALDH9A1	12
KEGG	hsa04913	Ovarian steroidogenesis	12/2250	51/8135	0.7911	1	0.9045	LDLR/ADCY4/GNAS/IGF1R/ADCY6/ALOX5/ADCY3/HSD3B2/PRKACB/INSR/ADCY9/CYP11A1	12
KEGG	hsa04072	Phospholipase D signaling pathway	37/2250	148/8135	0.7933	1	0.9045	PDGFA/DGKD/AGPAT3/FCER1A/AKT3/MTOR/GAB2/AGPAT2/ADCY4/CYTH2/DGKZ/SHC4/GNAS/ADCY6/PIK3R5/PRKCA/PIP5K1B/MRAS/RALGDS/RALA/ADCY3/DNM1/F2R/CYTH1/INSR/ADCY9/ARF6/SPHK2/RALB/PIP5K1A/PLCB1/SHC2/MAPK1/PDGFB/SHC1/RRAS2/FYN	37
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2250	27/8135	0.799	1	0.9045	B3GNT5/ST8SIA1/B3GNT2/ST3GAL3/FUT6/B4GALT4	6
KEGG	hsa05032	Morphine addiction	22/2250	91/8135	0.8052	1	0.9045	GNG4/GNG10/PDE4A/ADCY4/PDE4D/ARRB1/GNAS/GNG7/PDE4B/ADCY6/PRKCA/DRD1/GNAI2/ADCY3/GNB4/GABRG2/GRK5/PDE7B/PRKCB/PRKACB/ADCY9/GRK6	22
KEGG	hsa04974	Protein digestion and absorption	25/2250	103/8135	0.8107	1	0.9045	KCNK5/SLC1A5/SLC1A1/COL5A1/COL9A2/COL6A2/SLC36A1/COL18A1/CELA2B/KCNE3/COL8A2/SLC3A2/COL6A1/ATP1B1/COL4A6/COL11A1/KCNN4/PRCP/SLC38A2/ATP1B3/SLC36A4/SLC16A10/MEP1A/CPB1/CTRB1	25
KEGG	hsa04921	Oxytocin signaling pathway	38/2250	154/8135	0.8224	1	0.9045	CDKN1A/CAMK1/PPP1CB/ACTG1/MYLK2/ADCY4/SRC/CALML4/GNAS/MYL6/CAMK2A/KCNJ2/ADCY6/PIK3R5/PRKAB2/PRKCA/CACNG3/CACNA2D2/GNAI2/PRKAG2/ELK1/JUN/CAMK2G/ADCY3/MYL6B/CAMK2D/PRKCB/PRKACB/GNAQ/ADCY9/PPP1R12B/CACNB2/FOS/PLCB1/PPP1R12A/MAPK1/CCND1/ACTB	38
KEGG	hsa00562	Inositol phosphate metabolism	17/2250	73/8135	0.8338	1	0.9045	TPI1/PLCD3/MTMR3/INPP4A/PIKFYVE/IMPA2/PIP5K1B/PI4K2A/ITPKC/INPP1/MTMR14/PIK3C3/PIP4K2A/IPPK/PIP4K2B/PIP5K1A/PLCB1	17
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/2250	77/8135	0.8343	1	0.9045	ITGA2/ITGA3/DSC2/SGCB/ITGB8/ACTG1/LMNA/ATP2A1/TCF7L2/ITGA1/CACNG3/ITGA6/CACNA2D2/EMD/CTNNA1/ITGA2B/CACNB2/ACTB	18
KEGG	hsa04310	Wnt signaling pathway	41/2250	167/8135	0.84	1	0.9045	FOSL1/RAC1/VANGL1/TLE4/TLE2/WNT10B/NKD1/CAMK2A/DVL3/SFRP4/FZD6/TCF7L2/PRKCA/TLE3/DVL1/WNT7A/FRAT1/FZD8/JUN/INVS/FBXW11/CAMK2G/RAC2/BTRC/SFRP1/CAMK2D/RSPO3/FZD9/LRP6/PRKCB/PRKACB/CTBP1/APC/AXIN2/FZD5/PORCN/PPARD/CER1/PLCB1/CCND1/RAC3	41
KEGG	hsa00510	N-Glycan biosynthesis	11/2250	50/8135	0.8553	1	0.9045	DOLPP1/MGAT4B/MGAT5B/DPM2/MGAT4A/MGAT5/GANAB/MAN1A1/DOLK/ALG6/MOGS	11
KEGG	hsa04979	Cholesterol metabolism	11/2250	50/8135	0.8553	1	0.9045	LDLR/TSPO/MYLIP/LRPAP1/ABCA1/LRP1/VDAC1/LDLRAP1/CETP/LIPA/CYP7A1	11
KEGG	hsa00360	Phenylalanine metabolism	3/2250	16/8135	0.8615	1	0.9045	IL4I1/ALDH3A1/ALDH3B1	3
KEGG	hsa00592	alpha-Linolenic acid metabolism	5/2250	25/8135	0.862	1	0.9045	PLA2G12A/PLA2G2A/PLA2G2C/PLA2G5/PLB1	5
KEGG	hsa04260	Cardiac muscle contraction	20/2250	87/8135	0.8652	1	0.9045	COX8A/ASPH/ATP2A1/COX6A1/UQCRC1/ATP1B1/SLC9A7/CACNG3/TPM2/CACNA2D2/MYH7/ATP1B3/COX6B2/TNNC1/COX4I1/UQCR11/TPM1/CACNB2/MYH6/SLC9A6	20
KEGG	hsa00310	Lysine degradation	14/2250	63/8135	0.8678	1	0.9045	DOT1L/SETD7/ALDH2/PRDM16/TMLHE/EZH2/DLST/SETD1B/SETDB2/ALDH7A1/ALDH9A1/PLOD3/CAMKMT/SETDB1	14
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	34/2250	143/8135	0.8741	1	0.9045	LIF/SKIL/MAPK11/KLF4/AKT3/WNT10B/STAT3/MAPK12/DVL3/IGF1R/FZD6/ZFHX3/DVL1/WNT7A/FZD8/PCGF6/ACVR1C/ACVR2B/PCGF1/PCGF5/SMAD1/LEFTY1/DLX5/FZD9/APC/AXIN2/FZD5/ID1/JAK3/BMI1/MAPK1/SETDB1/KAT6A/JAK1	34
KEGG	hsa01523	Antifolate resistance	6/2250	30/8135	0.8763	1	0.9045	IL1B/ABCC1/TYMS/TNF/GGH/DHFR	6
KEGG	hsa04512	ECM-receptor interaction	20/2250	88/8135	0.8784	1	0.9045	SDC4/ITGA2/ITGA3/COL9A2/SPP1/COL6A2/ITGB8/THBS2/COL6A1/COL4A6/SDC1/ITGA1/CD47/ITGA6/VTN/CD44/ITGA2B/THBS4/SV2A/LAMA5	20
KEGG	hsa00071	Fatty acid degradation	9/2250	43/8135	0.8792	1	0.9045	ALDH2/ACSL1/ACSL4/CPT1A/ALDH7A1/ECI1/ALDH9A1/CYP2U1/HADHB	9
KEGG	hsa00860	Porphyrin metabolism	9/2250	43/8135	0.8792	1	0.9045	CPOX/FXN/MMAB/HMOX1/HEPH/BLVRA/HMOX2/PPOX/GUSB	9
KEGG	hsa04022	cGMP-PKG signaling pathway	40/2250	167/8135	0.8799	1	0.9045	PPIF/SRF/CREB3L2/PPP1CB/ADRA2B/AKT3/MYLK2/ADCY4/CALML4/ATP2A1/ADCY6/ATF4/PIK3R5/ATP1B1/KCNMB1/MEF2D/VASP/ATP2B4/KCNU1/BDKRB2/GNAI2/VDAC1/CNGA1/MYH7/ATP1B3/MEF2B/SLC25A5/PRKCE/ADCY3/GNAQ/INSR/ADCY9/SLC25A4/MYH6/PLCB1/GTF2IRD1/PPP1R12A/MAPK1/BAD/GTF2I	40
KEGG	hsa00790	Folate biosynthesis	5/2250	26/8135	0.8848	1	0.9045	GGH/DHFR/MOCS1/TPH1/SPR	5
KEGG	hsa05415	Diabetic cardiomyopathy	49/2250	203/8135	0.889	1	0.9045	PPIF/MAPK11/RAC1/GAPDH/NCF4/MMP9/COX8A/PPP1CB/CYBB/AKT3/MTOR/ATP2A1/CAMK2A/MAPK12/PDHB/NDUFB11/TGFB3/COX6A1/UQCRC1/SLC2A4/NDUFB8/PRKCA/NDUFS1/SP1/CTSD/NDUFS7/VDAC1/SLC25A5/COX6B2/CAMK2G/NDUFB10/RAC2/CYBA/NDUFC1/NDUFA9/COX4I1/UQCR11/CAMK2D/NDUFA12/PRKCB/INSR/SLC25A4/NCF1/NDUFA4/PLCB1/NDUFB2/TGFB1/MPC1/NDUFA13	49
KEGG	hsa04962	Vasopressin-regulated water reabsorption	9/2250	44/8135	0.8957	1	0.9045	CREB3L2/GNAS/ADCY6/DCTN5/AQP2/ADCY3/PRKACB/ADCY9/ARHGDIA	9
KEGG	hsa04151	PI3K-Akt signaling pathway	88/2250	354/8135	0.898	1	0.9045	NR4A1/GNG4/VEGFA/CDKN1A/ITGA2/CASP9/ITGA3/NTRK2/CSF1R/NTRK1/PDGFA/RAC1/CSF3R/YWHAH/MCL1/COL9A2/SPP1/YWHAE/GNG10/COL6A2/PPP2R1A/YWHAZ/EIF4EBP1/CREB3L2/CSF1/IL2RA/TLR4/AKT3/MTOR/ITGB8/IL2RB/CRTC2/IL4R/RPS6/IL2RG/CDK2/GNG7/IGF1R/THBS2/FGF9/ATF4/CCNE2/COL6A1/PIK3R5/FLT3/PPP2R3C/COL4A6/PRKCA/DDIT4/ITGA1/ITGA6/TLR2/VTN/PPP2CA/OSM/CD19/FLT1/RXRA/YWHAQ/ERBB2/PHLPP1/IL7R/GNB4/RBL2/BCL2L1/IL7/FLT4/SGK2/EIF4E2/IL4/F2R/FGF22/ITGA2B/INSR/PPP2R3B/FGF8/NTF3/THBS4/JAK3/MAPK1/CCND1/LAMA5/PDGFB/MLST8/VEGFC/BAD/MAGI1/JAK1	88
KEGG	hsa00590	Arachidonic acid metabolism	13/2250	61/8135	0.8981	1	0.9045	PTGIS/GPX1/GGT1/PLA2G12A/EPHX2/ALOX5/TBXAS1/PTGES2/PLA2G2A/PLA2G2C/CYP2U1/PLA2G5/PLB1	13
KEGG	hsa04350	TGF-beta signaling pathway	21/2250	94/8135	0.9011	1	0.9045	CDKN2B/PPP2R1A/TNF/RGMA/SMAD7/GREM2/TGFB3/ZFYVE9/SMAD6/SMURF1/PPP2CA/SP1/GDF7/ACVR1C/ACVR2B/SMAD1/LEFTY1/ID1/RGMB/TGFB1/MAPK1	21
KEGG	hsa04714	Thermogenesis	56/2250	232/8135	0.9029	1	0.9045	MAPK11/PPARG/DPF3/COX8A/CREB3L2/SIRT6/COX17/MTOR/SMARCB1/ACTG1/ADCY4/MAP2K3/RPS6/GNAS/MAPK12/NDUFB11/COX6A1/UQCRC1/ADCY6/ACSL1/PRDM16/ACTL6A/NDUFB8/COX18/PRKAB2/MAP3K5/SMARCA4/COA3/NDUFS1/PRKAG2/CNR1/NDUFS7/ARID1A/COX6B2/NDUFB10/ADCY3/NDUFC1/ACSL4/NDUFA9/COX4I1/UQCR11/CPT1A/NDUFA12/DPF1/COA5/PRKACB/COA4/ADCY9/NDUFA4/NDUFB2/NDUFAF5/NDUFA13/COX11/NDUFAF2/MLST8/ACTB	56
KEGG	hsa00350	Tyrosine metabolism	7/2250	36/8135	0.9058	1	0.9045	IL4I1/FAH/ALDH3A1/ALDH3B1/HGD/TYRP1/GSTZ1	7
KEGG	hsa00500	Starch and sucrose metabolism	7/2250	36/8135	0.9058	1	0.9045	HK1/GPI/HK2/PGM2L1/GYG2/PYGM/AMY2A	7
KEGG	hsa00512	Mucin type O-glycan biosynthesis	7/2250	36/8135	0.9058	1	0.9045	GALNT2/GALNT12/GALNT1/ST6GALNAC4/B4GALT5/GALNT10/C1GALT1	7
KEGG	hsa04622	RIG-I-like receptor signaling pathway	15/2250	70/8135	0.9068	1	0.9045	MAPK11/IRF7/ISG15/TNF/CXCL10/TRIM25/NFKBIB/MAPK12/CYLD/TANK/NFKBIA/AZI2/IRF3/TRAF2/TRAF6	15
KEGG	hsa00640	Propanoate metabolism	6/2250	32/8135	0.9125	1	0.9045	LDHA/LDHAL6B/ABAT/ACACB/ACSS1/PCCB	6
KEGG	hsa00515	Mannose type O-glycan biosynthesis	4/2250	23/8135	0.9153	1	0.9045	POMT2/FKTN/MGAT5B/ST3GAL3	4
KEGG	hsa05010	Alzheimer disease	95/2250	384/8135	0.9156	1	0.9045	TUBB6/PPIF/IL1B/CASP9/SLC39A1/GAPDH/TUBA1B/CDK5/SLC39A7/TUBA1C/COX8A/TNF/CSF1/CYBB/AKT3/MTOR/CAPN1/WNT10B/KLC1/TUBB/PSMD8/CALML4/ATP2A1/DVL3/NDUFB11/PSMD1/TUBB4B/PSMD2/FZD6/COX6A1/UQCRC1/ATF4/KLC3/AMBRA1/NDUFB8/SLC39A11/FAS/BID/MAP3K5/TUBB3/DVL1/ULK1/NDUFS1/PSMD9/LRP1/PSMA5/DDIT3/WNT7A/NDUFS7/FRAT1/TUBB2A/FZD8/VDAC1/PSMB7/TUBB4A/SLC25A5/COX6B2/NDUFB10/ATG2B/NDUFC1/KLC4/NDUFA9/BRAF/COX4I1/UQCR11/TRAF2/PIK3C3/EIF2AK3/PSMB5/ERN1/NAE1/NDUFA12/FZD9/LRP6/PSMB4/GNAQ/INSR/PSMA3/PIK3R4/APC/SLC25A4/AXIN2/FZD5/NDUFA4/PLCB1/SLC39A10/NDUFB2/PSMB1/PSMD7/NDUFA13/PSMB3/MAPK1/PSMC5/BAD/PSMD11	95
KEGG	hsa04728	Dopaminergic synapse	30/2250	132/8135	0.9177	1	0.9045	GNG4/MAPK11/GNG10/PPP2R1A/CREB3L2/PPP1CB/AKT3/ARRB1/CALML4/GNAS/CAMK2A/MAPK12/GNG7/ATF4/PPP2R3C/PRKCA/PPP2CA/DRD1/GNAI2/CAMK2G/GNB4/ARNTL/GSK3A/CAMK2D/PRKCB/PRKACB/GNAQ/PPP2R3B/FOS/PLCB1	30
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	50/2250	212/8135	0.9242	1	0.9045	VDR/VEGFA/BIRC5/KLF4/BCL6/CDC25A/CDC6/EIF4EBP1/KPNA2/CREB3L2/E2F1/AKT3/MTOR/STAT3/ADCY4/PAQR7/SRC/ARRB1/GNAS/FGF9/ADCY6/ATF4/EPHX2/JAG1/GSTO1/PRKCA/RXRA/GNAI2/JUN/KPNA3/GSTM1/ADCY3/GSTT1/ESR1/FGF22/STAT5A/MGST2/CHRNA3/PRKCB/PRKACB/ADCY9/FGF8/MGST3/TNFSF11/FOS/DLL1/MAPK1/CCND1/BAD/EPHX4	50
KEGG	hsa00380	Tryptophan metabolism	8/2250	42/8135	0.9275	1	0.9045	IL4I1/ALDH2/DLST/IDO1/TPH1/AANAT/ALDH7A1/ALDH9A1	8
KEGG	hsa04724	Glutamatergic synapse	25/2250	114/8135	0.9337	1	0.9045	GNG4/SLC1A1/GNG10/TRPC1/HOMER2/ADCY4/GLS2/HOMER1/GNAS/GNG7/ADCY6/PRKCA/DLGAP1/GNAI2/SLC38A2/ADCY3/GRIN3B/GNB4/PRKCB/PRKACB/GNAQ/ADCY9/PLCB1/MAPK1/DLG4	25
KEGG	hsa04973	Carbohydrate digestion and absorption	9/2250	47/8135	0.9342	1	0.9045	HK1/HK2/AKT3/ATP1B1/ATP1B3/PRKCB/PLCB1/GNAT3/AMY2A	9
KEGG	hsa00591	Linoleic acid metabolism	5/2250	29/8135	0.9349	1	0.9045	PLA2G12A/PLA2G2A/PLA2G2C/PLA2G5/PLB1	5
KEGG	hsa04923	Regulation of lipolysis in adipocytes	11/2250	56/8135	0.937	1	0.9045	AKT3/ADCY4/GNAS/ADCY6/GNAI2/TSHR/ADCY3/PRKACB/AQP7/INSR/ADCY9	11
KEGG	hsa04975	Fat digestion and absorption	8/2250	43/8135	0.9386	1	0.9045	AGPAT2/PLA2G12A/ABCA1/PLA2G2A/DGAT2/PLA2G2C/SLC27A4/PLA2G5	8
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/2250	223/8135	0.9408	1	0.9045	PPIF/MAPK11/VEGFA/RAC1/AS3MT/COX8A/AKT3/PTPN1/SRC/HMOX1/MAPK12/NDUFB11/COX6A1/UQCRC1/EPHX2/NDUFB8/NQO1/GSTO1/MAP3K5/PRKD3/NDUFS1/SLC26A6/NDUFS7/VDAC1/JUN/SLC25A5/COX6B2/NFKBIA/NDUFB10/GSTM1/CYBA/NDUFC1/MAP2K4/NDUFA9/BRAF/COX4I1/UQCR11/GSTT1/NDUFA12/MGST2/ACP1/SLC25A4/MGST3/NCF1/FOS/NDUFA4/NDUFB2/NDUFA13/MAPK1/AKR1A1/BAD/EPHX4	52
KEGG	hsa00100	Steroid biosynthesis	3/2250	20/8135	0.9441	1	0.9045	CYP27B1/SQLE/LIPA	3
KEGG	hsa00053	Ascorbate and aldarate metabolism	5/2250	30/8135	0.9466	1	0.9045	ALDH2/GUSB/ALDH7A1/ALDH9A1/AKR1A1	5
KEGG	hsa04720	Long-term potentiation	13/2250	67/8135	0.9552	1	0.9045	PPP1CB/CALML4/CAMK2A/ATF4/PRKCA/CAMK2G/BRAF/CAMK2D/PRKCB/PRKACB/GNAQ/PLCB1/MAPK1	13
KEGG	hsa04623	Cytosolic DNA-sensing pathway	12/2250	63/8135	0.9575	1	0.9045	IL1B/IRF7/IL18/TREX1/CXCL10/NFKBIB/RIPK3/POLR3H/POLR1D/NFKBIA/IRF3/POLR3GL	12
KEGG	hsa04727	GABAergic synapse	18/2250	89/8135	0.9587	1	0.9045	GNG4/GNG10/ADCY4/SRC/GLS2/ABAT/GNG7/ADCY6/PRKCA/GNAI2/SLC38A2/ADCY3/GNB4/GABRG2/PRKCB/PRKACB/ADCY9/SLC12A5	18
KEGG	hsa04929	GnRH secretion	12/2250	64/8135	0.9635	1	0.9045	SPP1/AKT3/TRPC1/ARRB1/HCN2/PRKCA/KCNN4/PRKCB/GNAQ/PLCB1/MAPK1/TRPC5	12
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/2250	27/8135	0.9641	1	0.9045	TECR/SCD/ELOVL7/ELOVL1	4
KEGG	hsa04742	Taste transduction	17/2250	86/8135	0.965	1	0.9045	KCNK5/ADCY4/SCN9A/ENTPD2/ADCY6/TAS2R19/TAS2R50/TAS2R20/TAS2R14/TAS2R43/TAS2R4/PRKACB/P2RY1/PLCB1/TAS2R5/GNAT3/TAS2R13	17
KEGG	hsa04730	Long-term depression	11/2250	60/8135	0.9659	1	0.9045	PPP2R1A/GNAS/IGF1R/PRKCA/PPP2CA/GNAI2/BRAF/PRKCB/GNAQ/PLCB1/MAPK1	11
KEGG	hsa04924	Renin secretion	13/2250	69/8135	0.9667	1	0.9045	CALML4/GNAS/PTGER4/KCNJ2/ADCY6/CTSB/GNAI2/CLCA2/PTGER2/PRKACB/GNAQ/CLCA1/PLCB1	13
KEGG	hsa00190	Oxidative phosphorylation	28/2250	134/8135	0.9715	1	0.9045	ATP6V0D1/COX8A/ATP6V0B/COX17/ATP6V1E1/NDUFB11/COX6A1/UQCRC1/ATP6V0C/NDUFB8/LHPP/ATP6V1A/NDUFS1/PPA2/NDUFS7/COX6B2/NDUFB10/NDUFC1/NDUFA9/COX4I1/ATP6V1G1/UQCR11/NDUFA12/ATP6V1E2/NDUFA4/NDUFB2/NDUFA13/COX11	28
KEGG	hsa04024	cAMP signaling pathway	49/2250	221/8135	0.9749	1	0.9045	ADORA2A/RAC1/PTCH1/PDE4A/CREB3L2/PPP1CB/AKT3/FFAR2/ADCY4/TIAM1/PDE4D/CALML4/GNAS/ATP2A1/CAMK2A/PDE4B/HCN2/PAK1/ADCY6/ATP1B1/VAV2/DRD1/ATP2B4/GNAI2/CNGA1/JUN/ARAP3/ATP1B3/TSHR/CAMK2G/NFKBIA/RAC2/PTGER2/ADCY3/GRIN3B/HTR6/BRAF/GHRL/CAMK2D/F2R/PRKACB/ADCY9/FOS/PPP1R12A/MAPK1/GIPR/BAD/RRAS2/RAC3	49
KEGG	hsa00513	Various types of N-glycan biosynthesis	6/2250	39/8135	0.977	1	0.9045	MGAT4B/MGAT4A/B4GALNT4/ST3GAL3/HEXB/MAN1A1	6
KEGG	hsa04744	Phototransduction	4/2250	29/8135	0.9771	1	0.9045	CALML4/GUCA1C/CNGA1/PDE6B	4
KEGG	hsa04723	Retrograde endocannabinoid signaling	30/2250	148/8135	0.9852	1	0.9045	GNG4/MAPK11/GNG10/ADCY4/MAPK12/GNG7/NDUFB11/ADCY6/NDUFB8/PRKCA/NDUFS1/GNAI2/CNR1/NDUFS7/NDUFB10/ADCY3/GNB4/NDUFC1/GABRG2/NDUFA9/NDUFA12/PRKCB/PRKACB/GNAQ/ADCY9/NDUFA4/PLCB1/NDUFB2/NDUFA13/MAPK1	30
KEGG	hsa04976	Bile secretion	16/2250	89/8135	0.9879	1	0.9045	SLC4A2/LDLR/ADCY4/GNAS/ADCY6/SLC51A/ATP1B1/RXRA/ATP1B3/ABCB4/CA2/SLC22A8/ADCY3/PRKACB/ADCY9/CYP7A1	16
KEGG	hsa04721	Synaptic vesicle cycle	13/2250	78/8135	0.9921	1	0.9045	SLC1A1/ATP6V0D1/CLTB/ATP6V0B/ATP6V1E1/ATP6V0C/STX1B/ATP6V1A/AP2S1/ATP6V1G1/DNM1/STX2/ATP6V1E2	13
KEGG	hsa04726	Serotonergic synapse	21/2250	115/8135	0.9931	1	0.9045	GNG4/GNG10/TRPC1/GNAS/HTR2A/GNG7/PRKCA/ALOX5/GNAI2/CYP2C18/GNB4/TPH1/HTR6/BRAF/PRKCB/PRKACB/GNAQ/CYP2D6/PLCB1/MAPK1/DUSP1	21
KEGG	hsa00982	Drug metabolism - cytochrome P450	11/2250	72/8135	0.9957	1	0.9045	GSTO1/GSTM1/GSTT1/ALDH3A1/ALDH3B1/MGST2/FMO2/FMO5/CYP2D6/MGST3/GSTK1	11
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	10/2250	69/8135	0.997	1	0.9045	HSD11B1/NAT1/GSTO1/CYP2C18/GSTM1/NAT2/GSTT1/MGST2/MGST3/GSTK1	10
KEGG	hsa04613	Neutrophil extracellular trap formation	36/2250	190/8135	0.9981	1	0.9045	PPIF/MAPK11/FPR1/RAC1/TLR8/FPR3/NCF4/CLEC7A/HMGB1/CYBB/TLR4/AKT3/MTOR/ACTG1/FCGR1A/SRC/MAPK12/PRKCA/TLR2/VDAC1/FPR2/SLC25A5/RAC2/MPO/CYBA/ITGA2B/PRKCB/HDAC9/SLC25A4/NCF1/CLCN5/PLCB1/ATG7/MAPK1/HDAC10/ACTB	36
KEGG	hsa00040	Pentose and glucuronate interconversions	3/2250	34/8135	0.9984	1	0.9045	RPE/GUSB/AKR1A1	3
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/2250	78/8135	0.9987	1	0.9045	CYP2S1/HSD11B1/GSTO1/GSTM1/GSTT1/ALDH3A1/ALDH3B1/MGST2/CYP2D6/MGST3/GSTK1	11
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	8/2250	66/8135	0.9993	1	0.9045	NARS2/YARS2/LARS2/MARS2/MTFMT/HARS2/VARS2/FARSA	8
KEGG	hsa00140	Steroid hormone biosynthesis	7/2250	61/8135	0.9994	1	0.9045	CYP7B1/HSD11B1/HSD17B8/DHRS11/HSD3B2/CYP11A1/CYP7A1	7
KEGG	hsa04950	Maturity onset diabetes of the young	1/2250	26/8135	0.9998	1	0.9045	PDX1	1
KEGG	hsa05206	MicroRNAs in cancer	59/2250	310/8135	0.9999	1	0.9045	VEGFA/NOTCH1/FSCN1/CDCA5/CDKN1A/KIF23/ABCC1/E2F2/MARCKS/PDGFA/MCL1/CDC25A/MMP9/TP63/ST14/E2F1/CDC25C/PLAU/MTOR/STAT3/PDCD4/PIM1/HMOX1/SHC4/GLS2/PAK4/UBE2I/BMF/CCNE2/EZR/PRKCA/DDIT4/STMN1/EZH2/SLC45A3/BAK1/CDKN2A/MDM4/SLC7A1/ERBB2/CD44/RECK/CRK/PRKCE/VIM/DICER1/PRKCB/TIMP3/TPM1/APC/MIR181D/ATM/CDC25B/BMI1/MAPK1/CCND1/PDGFB/SHC1/SIRT1	59
KEGG	hsa05033	Nicotine addiction	2/2250	40/8135	1	1	0.9045	GRIN3B/GABRG2	2
KEGG	hsa00830	Retinol metabolism	6/2250	68/8135	1	1	0.9045	CYP2S1/CYP26C1/DHRS4L2/CYP2C18/RDH10/DHRS3	6
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	13/2250	109/8135	1	1	0.9045	XRN2/NOP10/POP5/RIOK1/SBDS/GNL3/EMG1/FBL/MDN1/RPP30/LSG1/RCL1/NXF3	13
KEGG	hsa05322	Systemic lupus erythematosus	18/2250	136/8135	1	1	0.9045	CD86/IL10/CD80/TNF/HLA-DMA/FCGR1A/C1QB/HLA-DPA1/ACTN4/HLA-DRA/HLA-DMB/HLA-DQA2/SNRPB/C1QA/C1R/HLA-DPB1/C6/HLA-DRB1	18
KEGG	hsa04080	Neuroactive ligand-receptor interaction	63/2250	353/8135	1	1	0.9045	ADORA2A/FPR1/NMB/FPR3/THRA/ADRA2B/CHRNA10/CHRNA5/P2RY13/NR3C1/TSPO/HCRT/P2RX1/F2RL2/P2RY11/HTR2A/PTGER4/CYSLTR1/P2RX6/CCKAR/S1PR1/CCK/GPR35/UTS2R/LTB4R/P2RY10/PATE4/DRD1/BDKRB2/VIPR1/CNR1/NTSR1/FPR2/CHRNA1/C3AR1/TSHR/TACR2/PTGER2/PMCH/GRIN3B/GABRG2/TBXA2R/NPBWR2/PTGER1/HTR6/ADM/GHRL/INSL3/PTH2R/P2RX5/F2R/CHRNA3/P2RY1/NPFF/CHRNG/LTB4R2/NMUR1/GALR2/PTAFR/P2RX7/GIPR/TAAR1/MC3R	63
KEGG	hsa05034	Alcoholism	26/2250	187/8135	1	1	0.9045	GNG4/SLC29A2/ADORA2A/NTRK2/GNG10/FOSB/CREB3L2/PPP1CB/SLC29A1/SHC4/CALML4/GNAS/GNG7/ATF4/DRD1/GNAI2/GRIN3B/GNB4/SLC29A3/BRAF/PRKACB/HDAC9/SHC2/MAPK1/HDAC10/SHC1	26
KEGG	hsa04740	Olfactory transduction	49/2250	440/8135	1	1	0.9045	ARRB1/CALML4/OR56B1/CAMK2A/GNG7/OR7E24/OR2B11/OR10V1/OR8D4/OR5V1/OR4F21/OR51A2/OR14C36/OR52N4/OR5B17/CAMK2G/OR2A2/OR5D14/ADCY3/OR5J2/OR8K3/OR2T6/OR11H2/OR9A2/CAMK2D/OR10G7/OR4P4/OR6X1/PRKACB/OR4M1/OR2A7/OR7D4/OR5R1/OR2S2/OR2W3/OR6B1/OR6S1/OR10W1/OR4M2/OR52H1/OR2M3/ANO2/OR52K1/OR6C6/OR10K1/OR51G2/OR4Q3/OR13D1/OR7C2	49