ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	93/1759	222/8135	4.592e-12	1.534e-09	1.107e-09	MAPK9/PRKACB/IL15/EGR1/AKT2/BCL2L1/PTTG1/IL15RA/ATM/CHEK1/POLB/TGFBR2/ADCY6/IL2RG/JUN/MAD2L1/CRTC1/CCND3/IL1R1/CCNA2/LCK/PIK3CA/ZFP36/VDAC3/CD3E/ADCY7/CCNE2/HLA-DOB/TRRAP/XPO1/STAT5A/CD3D/CD3G/PIK3CB/NFKB2/MAP2K4/CSF2/E2F3/TERT/SMAD2/ITGB2/CRTC3/KAT2B/NFATC4/SRF/CD40/GPS2/FOS/IL2RB/TGFB2/HLA-F/CDKN1A/CCNB2/CDC20/CDC16/JAK1/JAK3/NFYB/HLA-DMB/VAC14/CREBBP/BUB1B/CREB3/TP53/NRAS/ADCY1/MAPK1/MYC/HLA-C/CCNE1/PPP3CC/HLA-DPB1/ETS1/HLA-DPA1/TNFRSF1A/MSX2/PPP3CB/IL6/B2M/BUB3/CDC23/HLA-DMA/HLA-G/SLC25A31/MAD1L1/ADCY8/NFKB1/MAPK8/PIK3R1/PRKACA/ITGAL/ATF6B/HLA-DQB1	93
KEGG	hsa05169	Epstein-Barr virus infection	85/1759	202/8135	2.95e-11	4.927e-09	3.556e-09	IRF9/CXCL10/MAPK9/PLCG2/AKT2/FAS/TAP1/HES1/MAP2K7/TAB2/STAT1/MAPK14/BLNK/TRAF6/ENTPD1/PSMC2/OAS2/GADD45B/JUN/CCND3/CCNA2/PIK3CA/CD3E/CCNE2/HLA-DOB/SYK/CD3D/CD3G/PIK3CB/NFKB2/MAP2K4/E2F3/MAP3K7/RBPJL/DDB2/IFNAR1/CD40/FADD/CASP3/PSMD3/HLA-F/NFKBIE/TAPBP/RBPJ/RUNX3/TBK1/CDKN1A/CD247/CD19/JAK1/JAK3/DDX58/HLA-DMB/BTK/PSMD4/TRAF3/TP53/RAC1/MYC/IFNA1/HLA-C/CIR1/CCNE1/HLA-DPB1/CDKN1B/HLA-DPA1/OAS1/IFNAR2/BAK1/IL6/NCOR2/B2M/TRAF5/HLA-DMA/HLA-G/TRADD/NFKB1/IRF7/MAPK8/PIK3R1/PSMD8/HDAC1/CD58/ITGAL/HLA-DQB1	85
KEGG	hsa04658	Th1 and Th2 cell differentiation	42/1759	92/8135	2.124e-07	2.364e-05	1.706e-05	JAK2/MAPK9/STAT1/MAPK14/IL2RG/IL13/JUN/LCK/CD3E/HLA-DOB/STAT5A/CD3D/PRKCQ/CD3G/STAT4/RBPJL/FOS/IL2RB/STAT6/NFKBIE/RBPJ/RUNX3/CD247/JAK1/JAK3/HLA-DMB/IL5/MAPK1/IFNGR2/PPP3CC/HLA-DPB1/HLA-DPA1/PPP3CB/HLA-DMA/MAML3/NFKB1/LAT/IFNG/MAML1/MAPK8/PLCG1/HLA-DQB1	42
KEGG	hsa04659	Th17 cell differentiation	46/1759	108/8135	6.915e-07	5.774e-05	4.167e-05	JAK2/MAPK9/STAT1/IL27RA/MAPK14/IL21R/TGFBR2/IL2RG/JUN/RXRB/IL1R1/LCK/CD3E/HLA-DOB/STAT5A/CD3D/IL6ST/PRKCQ/CD3G/SMAD2/FOS/IL2RB/STAT6/NFKBIE/CD247/HSP90AA1/JAK1/JAK3/HLA-DMB/MAPK1/IFNGR2/FOXP3/PPP3CC/HLA-DPB1/HLA-DPA1/PPP3CB/IL6/HLA-DMA/NFKB1/LAT/IFNG/MAPK8/IL23A/PLCG1/AHR/HLA-DQB1	46
KEGG	hsa05170	Human immunodeficiency virus 1 infection	76/1759	212/8135	1.082e-06	6.384e-05	4.607e-05	MAPK9/PLCG2/AKT2/FAS/BCL2L1/GNAI3/TAP1/CCR5/MAP2K7/ATM/TAB2/PAK2/FBXW11/CHEK1/MAPK14/RBX1/TRAF6/AP1S2/JUN/GNG3/PIK3CA/CD3E/CCNB1/WEE1/PXN/PRKCB/AP1S1/APOBEC3G/CD3D/CD3G/PAK3/PIK3CB/MAP3K7/APOBEC3B/ITPR2/NFATC4/APOBEC3C/FOS/CDK1/FADD/CASP3/HLA-F/TAPBP/TBK1/TNFRSF1B/CCNB2/CD247/CXCR4/GNA11/DCAF1/GNAI2/NRAS/RAC1/MAPK1/IFNA1/HLA-C/ITPR1/PPP3CC/GNB3/TNFRSF1A/BAK1/PPP3CB/B2M/TRAF5/CALML3/CALM1/HLA-G/TRADD/RNF7/RAC2/NFKB1/PAK1/TRIM5/MAPK8/PIK3R1/PLCG1	76
KEGG	hsa04110	Cell cycle	51/1759	126/8135	1.147e-06	6.384e-05	4.607e-05	PTTG1/ATM/PCNA/CHEK1/RBX1/CDC7/CDK7/GADD45B/MAD2L1/CCND3/CCNA2/CCNB1/WEE1/CCNE2/MCM5/SMC1A/YWHAZ/CDC6/TTK/E2F3/SMAD2/CDC45/MCM2/ORC3/CDK1/TGFB2/MCM6/ORC4/CDKN1A/MCM3/CCNB2/YWHAH/CDC20/CDC25B/CDC16/CREBBP/BUB1B/STAG2/TP53/MYC/STAG1/RBL1/CCNE1/CDKN1B/E2F4/BUB3/CDC23/MAD1L1/ZBTB17/CDKN2D/HDAC1	51
KEGG	hsa05164	Influenza A	64/1759	171/8135	1.421e-06	6.782e-05	4.895e-05	JAK2/IRF9/CXCL10/IFIH1/AKT2/SOCS3/FAS/STAT1/TNFSF10/CCL5/OAS2/CCND3/TLR3/PIK3CA/TRIM25/HLA-DOB/PRKCB/XPO1/CASP1/NXT2/TNFRSF10B/PIK3CB/RAB11A/IFNAR1/TPSD1/TLR7/FADD/CASP3/TBK1/TMPRSS2/PRSS2/TPSAB1/MX1/JAK1/DDX58/HLA-DMB/CREBBP/TRAF3/NXF3/TPSB2/MAPK1/IFNGR2/IFNA1/PLG/RNASEL/MX2/HLA-DPB1/IL18/HLA-DPA1/TNFRSF1A/OAS1/IFNAR2/BAK1/IL6/HLA-DMA/SLC25A31/TRADD/NFKB1/ADAR/IRF7/IFNG/PYCARD/PIK3R1/HLA-DQB1	64
KEGG	hsa04380	Osteoclast differentiation	51/1759	128/8135	2.004e-06	8.369e-05	6.04e-05	IRF9/MAPK9/PLCG2/JUNB/AKT2/SOCS3/MAP2K7/TAB2/STAT1/FCGR2B/MAPK14/BLNK/TRAF6/TGFBR2/FOSB/JUN/IL1R1/LCK/PIK3CA/SYK/SIRPG/PIK3CB/NFKB2/MAP3K7/IFNAR1/CSF1R/FOS/TGFB2/FOSL2/ITGB3/JAK1/SQSTM1/BTK/RAC1/MAPK1/IFNGR2/JUND/PPP3CC/NCF4/CSF1/TNFRSF1A/LILRB5/IFNAR2/PPP3CB/LILRA5/LILRB2/LILRB4/NFKB1/IFNG/MAPK8/PIK3R1	51
KEGG	hsa05162	Measles	54/1759	139/8135	2.537e-06	9.416e-05	6.796e-05	IRF9/MAPK9/IFIH1/AKT2/FAS/BCL2L1/TAB2/STAT1/FCGR2B/TRAF6/IL2RG/OAS2/JUN/CCND3/SLAMF1/PIK3CA/CD3E/CCNE2/STAT5A/CD3D/CD3G/PIK3CB/MAP3K7/IFNAR1/TLR7/FOS/FADD/CASP3/IL2RB/EIF2AK1/TBK1/MX1/JAK1/JAK3/DDX58/TRAF3/TP53/IFNA1/MX2/CCNE1/CDKN1B/OAS1/IFNAR2/BAK1/IL6/HSPA1L/CD46/TRADD/NFKB1/ADAR/IRF7/RAB9A/MAPK8/PIK3R1	54
KEGG	hsa04660	T cell receptor signaling pathway	43/1759	104/8135	4.072e-06	0.000136	9.816e-05	MAPK9/MALT1/AKT2/MAP2K7/PAK2/MAPK14/NCK1/JUN/PTPRC/LCK/PIK3CA/CD3E/CD8A/RASGRP1/VAV2/CD3D/PRKCQ/CD3G/PAK3/PIK3CB/CSF2/MAP3K7/FOS/ITK/NFKBIE/CD247/IL10/IL5/CTLA4/PTPN6/NRAS/MAPK1/PPP3CC/CD40LG/VAV1/PPP3CB/NFKB1/LAT/PAK1/IFNG/MAPK8/PIK3R1/PLCG1	43
KEGG	hsa04010	MAPK signaling pathway	96/1759	294/8135	5.344e-06	0.0001622	0.0001171	MAPK9/PRKACB/FGFR1/AKT2/FAS/PTPN7/TAOK3/MAP2K7/TAB2/PAK2/DUSP1/MAPK14/TRAF6/TGFBR2/CACNA1I/FGF21/GADD45B/JUN/RASA1/IL1R1/PRKCB/CACNA1B/RASGRP1/PLA2G4A/FGFR4/STMN1/PPP5C/NFKB2/MAP3K11/MAP2K4/CACNG2/MAP3K7/RASGRF1/NTRK2/RPS6KA1/FLNB/SRF/CSF1R/FOS/CASP3/TAOK1/TGFB2/DUSP9/NLK/LAMTOR3/NTRK1/FGF5/MAPK8IP2/CDC25B/CACNG5/CACNG1/EGFR/PDGFC/ARAF/CACNA1S/MAX/TP53/NRAS/EREG/RAC1/MAPK1/NF1/NR4A1/RPS6KA5/MYC/JUND/PLA2G4C/PPP3CC/MAPT/FLT3LG/CSF1/FGF17/TNFRSF1A/MAP4K1/EFNA5/CACNA1H/PPP3CB/CACNA1E/AREG/PDGFA/ANGPT2/RRAS/BDNF/HSPA1L/EFNA4/TRADD/MAPK8IP3/RAC2/NFKB1/PAK1/MAPK8/PRKACA/MAP3K2/RPS6KA4/CD14/RASA2	96
KEGG	hsa03440	Homologous recombination	22/1759	41/8135	6.746e-06	0.0001878	0.0001355	TOPBP1/ATM/POLD3/MRE11/RPA3/XRCC3/XRCC2/RAD51D/PALB2/BLM/BRCA2/TOP3A/RPA4/BRCC3/RAD52/BARD1/RPA2/TOP3B/RBBP8/NBN/RAD51B/RPA1	22
KEGG	hsa03030	DNA replication	20/1759	36/8135	8.83e-06	0.0002269	0.0001637	RFC4/PCNA/RNASEH2A/POLD3/RPA3/RFC1/POLA1/MCM5/RFC3/MCM2/MCM6/RPA4/MCM3/RFC5/RPA2/FEN1/RPA1/RNASEH2B/DNA2/POLE	20
KEGG	hsa05161	Hepatitis B	58/1759	162/8135	2.096e-05	5e-04	0.0003609	JAK2/MAPK9/IFIH1/AKT2/FAS/MAP2K7/TAB2/STAT1/PCNA/MAPK14/TRAF6/TGFBR2/JUN/TLR3/CCNA2/PIK3CA/VDAC3/CCNE2/PRKCB/STAT5A/YWHAZ/PIK3CB/MAP2K4/E2F3/MAP3K7/STAT4/DDB2/IFNAR1/NFATC4/FOS/FADD/CASP3/TGFB2/STAT6/TBK1/CDKN1A/JAK1/JAK3/DDX58/ARAF/CREBBP/TRAF3/HSPG2/CREB3/TP53/NRAS/MAPK1/MYC/IFNA1/ATP6AP1/CCNE1/IL6/EGR3/NFKB1/IRF7/MAPK8/PIK3R1/ATF6B	58
KEGG	hsa05203	Viral carcinogenesis	69/1759	204/8135	3.175e-05	0.0007071	0.0005103	GSN/IRF9/PRKACB/SCIN/HDAC6/CCR5/GTF2E1/HDAC3/CHEK1/POLB/JUN/CCND3/CCNA2/GTF2E2/PIK3CA/VDAC3/HPN/CCNE2/SYK/TRAF1/PXN/STAT5A/GTF2H1/YWHAZ/IL6ST/PIK3CB/NFKB2/RBPJL/KAT2B/SRF/CDK1/CASP3/HLA-F/RBPJ/CDKN1A/YWHAH/CDC20/JAK1/JAK3/HDAC7/VAC14/CREBBP/TRAF3/CREB3/TP53/NRAS/RAC1/MAPK1/HLA-C/CHD4/RBL1/CCNE1/CDKN1B/HNRNPK/REL/BAK1/TRAF5/GTF2B/EGR3/HLA-G/MAD1L1/TRADD/NFKB1/IRF7/PIK3R1/PRKACA/HDAC1/ATF6B/RASA2	69
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	66/1759	194/8135	3.82e-05	0.0007975	0.0005755	JAK2/MICB/IRF9/MAPK9/PLCG2/AKT2/FAS/CCR5/MAP2K7/CTNNB1/STAT1/MAPK14/LEF1/JUN/GNG3/TLR3/PIK3CA/ZFP36/SYK/IL6ST/UBC/PIK3CB/MAP2K4/CSF2/E2F3/ITPR2/IFNAR1/NFATC4/FOS/FADD/CASP3/PIK3R5/PTGS2/HLA-F/CD86/TBK1/CDKN1A/JAK1/CREBBP/TRAF3/TP53/NRAS/RAC1/MAPK1/MYC/CLEC2B/IFNA1/HLA-C/ITPR1/PPP3CC/GNB3/TNFRSF1A/IFNAR2/BAK1/PPP3CB/IL6/ANGPT2/CALML3/CALM1/HLA-G/TRADD/NFKB1/IRF7/MAPK8/PIK3R1/PLCG1	66
KEGG	hsa04630	JAK-STAT signaling pathway	57/1759	162/8135	4.368e-05	0.0008582	0.0006194	JAK2/IRF9/IL15/AKT2/SOCS3/BCL2L1/IL15RA/STAT1/OSM/IL27RA/IL21R/CTF1/IL2RG/IL13/LIF/CCND3/PIK3CA/EPOR/STAT5A/IL6ST/CSF2RB/PIK3CB/CSF2/STAT4/IFNAR1/IL2RB/STAM2/CSH1/STAT6/CDKN1A/IL7/IL10RB/IL10RA/JAK1/JAK3/EGFR/MCL1/IL10/CREBBP/PTPN2/IL5/PTPN6/IL7R/MYC/IFNGR2/IFNA1/IFNAR2/IL6/PDGFA/CNTFR/IL11/PIAS1/EPO/IFNG/PIK3R1/IL23A/SOCS2	57
KEGG	hsa04668	TNF signaling pathway	42/1759	112/8135	8.475e-05	0.001573	0.001135	CXCL10/MAPK9/JUNB/IL15/AKT2/SOCS3/FAS/MAP2K7/TAB2/BIRC3/CCL5/MAPK14/LIF/JUN/PIK3CA/TRAF1/PIK3CB/MAP2K4/CSF2/MAP3K7/MMP14/FOS/FADD/CASP3/PTGS2/TNFRSF1B/NOD2/TRAF3/CREB3/MAPK1/RPS6KA5/CSF1/TNFRSF1A/IL6/TRAF5/TRADD/NFKB1/MAPK8/PIK3R1/BAG4/RPS6KA4/ATF6B	42
KEGG	hsa04064	NF-kappa B signaling pathway	39/1759	104/8135	0.0001499	0.002635	0.001902	PLCG2/MALT1/BCL2L1/ATM/TAB2/BIRC3/BLNK/TRAF6/PARP1/GADD45B/IL1R1/LCK/TRIM25/SYK/TRAF1/PRKCB/PRKCQ/NFKB2/MAP3K7/CD40/PTGS2/CARD14/CCL13/DDX58/UBE2I/BTK/TRAF3/PIDD1/TNFRSF1A/CD40LG/TRAF5/TRADD/PLAU/NFKB1/LAT/LY96/PLCG1/LTB/CD14	39
KEGG	hsa04935	Growth hormone synthesis, secretion and action	43/1759	119/8135	0.0001869	0.003051	0.002202	JAK2/MAPK9/PLCG2/PRKACB/JUNB/AKT2/SOCS3/GNAI3/STAT1/MAPK14/ADCY6/PIK3CA/ADCY7/PRKCB/STAT5A/SSTR1/PIK3CB/MAP2K4/ITPR2/FOS/CSH1/SSTR3/CREBBP/CACNA1S/GNA11/CREB3/GNAI2/NRAS/ADCY1/MAPK1/ITPR1/GHSR/IGFALS/SSTR2/IRS2/SHC1/ADCY8/MAPK8/PIK3R1/PRKACA/PLCG1/SOCS2/ATF6B	43
KEGG	hsa05135	Yersinia infection	48/1759	137/8135	0.0001918	0.003051	0.002202	MAPK9/SKAP2/AKT2/MAP2K7/TAB2/PIP5K1A/ELMO1/MAPK14/TRAF6/JUN/ACTR2/ARPC5/LCK/PIK3CA/PXN/CD8A/VAV2/CASP1/PIP5K1B/ITGA4/PIK3CB/MAP2K4/MAP3K7/RPS6KA1/BAIAP2/FOS/GIT2/TBK1/ROCK1/IL10/FN1/WASL/RAC1/MAPK1/FYB1/IL18/WIPF1/VAV1/IL6/RAC2/ACTR3/NFKB1/LAT/PYCARD/MAPK8/PIK3R1/PLCG1/PKN1	48
KEGG	hsa04218	Cellular senescence	53/1759	156/8135	0.0002238	0.003398	0.002452	AKT2/HIPK2/ATM/FBXW11/CHEK1/MAPK14/MRE11/TGFBR2/RAD1/GADD45B/CCND3/CCNA2/PIK3CA/VDAC3/CCNB1/CCNE2/HIPK1/PIK3CB/E2F3/SMAD2/ITPR2/PPID/NFATC4/CDK1/TGFB2/HLA-F/CDKN1A/CCNB2/PPP1CA/SQSTM1/ZFP36L1/TP53/NRAS/MAPK1/MYC/HLA-C/ITPR1/RBL1/CCNE1/PPP3CC/RHEB/ETS1/NBN/E2F4/PPP3CB/IL6/RRAS/CALML3/CALM1/HLA-G/SLC25A31/NFKB1/PIK3R1	53
KEGG	hsa05160	Hepatitis C	53/1759	157/8135	0.0002682	0.003895	0.002811	IRF9/CXCL10/AKT2/SOCS3/FAS/CTNNB1/STAT1/TRAF6/OAS2/TLR3/LDLR/PIK3CA/PPP2CB/YWHAZ/PIK3CB/E2F3/IFNAR1/CLDN11/FADD/CASP3/EIF2AK1/TBK1/CDKN1A/YWHAH/MX1/JAK1/DDX58/EGFR/ARAF/TRAF3/TP53/NRAS/MAPK1/MYC/IFNA1/RNASEL/PPP2R1A/MX2/NR1H3/TNFRSF1A/PPP2CA/PPP2R1B/OAS1/IFNAR2/BAK1/PIAS1/TRADD/NFKB1/EIF3E/IRF7/IFNG/PIK3R1/IFIT1	53
KEGG	hsa05132	Salmonella infection	77/1759	249/8135	0.000324	0.004509	0.003254	MAPK9/AKT2/EXOC5/EXOC2/MAP2K7/TAB2/CTNNB1/TNFSF10/ACTR10/BIRC3/ELMO1/MAPK14/RIPK2/TRAF6/PLEKHM2/LEF1/ABI1/JUN/ACTR2/ACBD3/PTPRC/ARPC5/CYFIP2/PIK3CA/DYNC1I2/CASP1/TNFRSF10B/PAK3/PIK3CB/MAP2K4/ARL8B/GSDMD/MAP3K7/CYTH3/CYTH1/MYL5/VPS41/FLNB/DCTN3/ANXA2/FOS/FADD/CASP3/GCC2/RHOH/HSP90AA1/TUBA8/TUBB/VPS39/WASL/EXOC7/DYNLT1/RAC1/MAPK1/TUBA1A/MYC/RHOB/TUBB2A/IL18/TNFRSF1A/BAK1/IL6/RRAS/VPS11/DYNC1LI1/TXN2/TRADD/ACTR3/NFKB1/KLC1/PAK1/RAB9A/PYCARD/MAPK8/LY96/PKN1/CD14	77
KEGG	hsa05340	Primary immunodeficiency	18/1759	38/8135	0.0003686	0.004924	0.003554	RFX5/TAP1/BLNK/IL2RG/PTPRC/LCK/CD3E/CD8A/AIRE/CD3D/CD40/CD19/RFXANK/JAK3/BTK/IL7R/CD40LG/ADA	18
KEGG	hsa05140	Leishmaniasis	30/1759	77/8135	0.0003954	0.00508	0.003666	JAK2/TAB2/STAT1/EEF1A1/MAPK14/TRAF6/JUN/HLA-DOB/PRKCB/ITGA4/MAP3K7/ITGB2/FOS/TGFB2/PTGS2/JAK1/HLA-DMB/IL10/PTPN6/MARCKSL1/MAPK1/IFNGR2/NCF4/HLA-DPB1/CR1/HLA-DPA1/HLA-DMA/NFKB1/IFNG/HLA-DQB1	30
KEGG	hsa04140	Autophagy - animal	48/1759	141/8135	0.0004124	0.005101	0.003681	GABARAPL1/MAPK9/PRKACB/AKT2/BCL2L1/RAB8A/ATG4A/TRAF6/MTMR4/PIK3CA/PPP2CB/SH3GLB1/VAMP8/ATG2B/MTMR14/PRKCQ/PIK3CB/MAP3K7/MTMR3/STK11/DDIT4/TBK1/ATG5/PRKCD/SQSTM1/ATG13/UVRAG/NRAS/WIPI1/MAPK1/ITPR1/RUBCN/RHEB/PPP2CA/ATG4B/RRAS/IRS2/ERN1/LAMP1/RRAGC/ATG16L1/DAPK2/MAPK8/PIK3R1/PRKAA2/PRKACA/SNAP29/ULK1	48
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	45/1759	131/8135	0.0004938	0.00589	0.004251	MICB/PLCG2/FAS/TNFSF10/LCK/ICAM2/PIK3CA/SYK/PRKCB/VAV2/TNFRSF10B/PIK3CB/CSF2/PRF1/ITGB2/IFNAR1/SH2D1A/CASP3/CD247/NCR2/CD48/ARAF/KIR2DS3/PTPN6/NRAS/RAC1/MAPK1/IFNGR2/IFNA1/HLA-C/PPP3CC/IFNAR2/VAV1/PPP3CB/NCR1/HLA-G/SHC1/KLRD1/RAC2/LAT/PAK1/IFNG/PIK3R1/PLCG1/ITGAL	45
KEGG	hsa04662	B cell receptor signaling pathway	31/1759	82/8135	0.0005886	0.006779	0.004892	PLCG2/MALT1/AKT2/FCGR2B/BLNK/CD72/JUN/PIK3CA/SYK/PRKCB/VAV2/PIK3CB/FOS/NFKBIE/CD19/BTK/PTPN6/NRAS/RAC1/MAPK1/PPP3CC/CD79B/LILRB5/VAV1/PPP3CB/LILRA5/LILRB2/LILRB4/RAC2/NFKB1/PIK3R1	31
KEGG	hsa04620	Toll-like receptor signaling pathway	37/1759	104/8135	0.0007195	0.00801	0.005781	CXCL10/MAPK9/CXCL9/AKT2/MAP2K7/TAB2/STAT1/CCL5/MAPK14/TRAF6/CXCL11/JUN/TLR3/PIK3CA/TLR8/PIK3CB/MAP2K4/MAP3K7/IFNAR1/TLR7/CD40/FOS/FADD/CD86/TBK1/TRAF3/RAC1/MAPK1/IFNA1/IFNAR2/IL6/NFKB1/IRF7/MAPK8/PIK3R1/LY96/CD14	37
KEGG	hsa05145	Toxoplasmosis	39/1759	112/8135	0.0008467	0.009122	0.006584	JAK2/MAPK9/AKT2/BCL2L1/GNAI3/CCR5/TAB2/STAT1/BIRC3/MAPK14/TRAF6/LDLR/HLA-DOB/MAP3K7/CD40/CASP3/PIK3R5/TGFB2/IL10RB/IL10RA/LAMC3/JAK1/HLA-DMB/IL10/GNAI2/MAPK1/IFNGR2/HLA-DPB1/HLA-DPA1/TNFRSF1A/CD40LG/PPIF/HLA-DMA/HSPA1L/NFKB1/IFNG/MAPK8/LY96/HLA-DQB1	39
KEGG	hsa03420	Nucleotide excision repair	20/1759	47/8135	0.0009937	0.0101	0.007286	RFC4/PCNA/POLD3/RBX1/RPA3/CDK7/RFC1/RFC3/GTF2H1/DDB2/XPA/RPA4/ERCC8/RFC5/RPA2/XPC/RPA1/ERCC5/POLE/RAD23B	20
KEGG	hsa05142	Chagas disease	36/1759	102/8135	0.0009975	0.0101	0.007286	MAPK9/AKT2/FAS/GNAI3/CCL5/MAPK14/TRAF6/TGFBR2/JUN/PIK3CA/CD3E/PPP2CB/CD3D/CD3G/PIK3CB/MAP2K4/SMAD2/FOS/FADD/TGFB2/CD247/IL10/GNA11/GNAI2/ADCY1/MAPK1/IFNGR2/PPP2R1A/TNFRSF1A/PPP2CA/PPP2R1B/IL6/NFKB1/IFNG/MAPK8/PIK3R1	36
KEGG	hsa05165	Human papillomavirus infection	95/1759	331/8135	0.001197	0.01138	0.008215	IRF9/PRKACB/AKT2/FAS/ATP6V1D/HES1/ATM/CTNNB1/STAT1/TUBG1/ATP6V1H/COL6A1/MPP5/ITGB4/PRKCZ/LLGL2/CCND3/ATP6V0E1/TLR3/CCNA2/FZD2/PIK3CA/CCNE2/PPP2CB/PXN/ITGA7/ATP6V1E1/ITGA4/HEYL/WNT7A/PIK3CB/TERT/RBPJL/FZD3/MFNG/IFNAR1/TNXB/FADD/CASP3/ATP6V1A/MAGI1/PTGS2/HLA-F/ITGB3/RBPJ/WNT5A/TBK1/CDKN1A/MX1/LAMC3/JAK1/EGFR/FZD9/FN1/CREBBP/PPP2R5C/TRAF3/CREB3/FZD1/TP53/NRAS/MAPK1/PSEN1/IFNA1/HLA-C/ATP6AP1/PPP2R1A/CHD4/MX2/RBL1/CCNE1/ITGB7/CDKN1B/WNT6/RHEB/TNFRSF1A/PPP2CA/PPP2R1B/IFNAR2/BAK1/ATP6V1B1/HES2/LFNG/HLA-G/TRADD/MAML3/NFKB1/THBS2/MAML1/PIK3R1/PRKACA/COL4A3/HDAC1/WNT1/FZD6	95
KEGG	hsa05330	Allograft rejection	17/1759	38/8135	0.001201	0.01138	0.008215	FAS/HLA-DOB/PRF1/CD40/HLA-F/CD86/HLA-DMB/IL10/IL5/HLA-C/HLA-DPB1/HLA-DPA1/CD40LG/HLA-DMA/HLA-G/IFNG/HLA-DQB1	17
KEGG	hsa03430	Mismatch repair	12/1759	23/8135	0.001227	0.01138	0.008215	RFC4/MLH1/PCNA/POLD3/RPA3/RFC1/RFC3/MSH2/RPA4/RFC5/RPA2/RPA1	12
KEGG	hsa04934	Cushing syndrome	50/1759	155/8135	0.001262	0.01139	0.00822	PRKACB/GNAI3/CTNNB1/CACNA1I/LEF1/ADCY6/FZD2/LDLR/ADCY7/CCNE2/KCNK3/AGT/WNT7A/NR5A1/E2F3/ITPR2/FZD3/KCNK2/WNT5A/CDKN1A/EGFR/FZD9/CACNA1S/WDR5B/GNA11/CREB3/CYP17A1/FZD1/GNAI2/ADCY1/MAPK1/NR4A1/ITPR1/CCNE1/CDKN1B/WNT6/CACNA1H/USP8/CAMK2B/CRH/ASH2L/ADCY8/PRKACA/PDE8A/WNT1/RBBP5/AIP/AHR/FZD6/ATF6B	50
KEGG	hsa05321	Inflammatory bowel disease	25/1759	65/8135	0.001457	0.01281	0.009243	STAT1/IL21R/IL2RG/IL13/JUN/HLA-DOB/STAT4/SMAD2/TGFB2/STAT6/NOD2/HLA-DMB/IL10/IL5/IFNGR2/FOXP3/HLA-DPB1/IL18/HLA-DPA1/IL6/HLA-DMA/NFKB1/IFNG/IL23A/HLA-DQB1	25
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	34/1759	97/8135	0.001558	0.01334	0.009628	GSN/PLCG2/AKT2/SCIN/PIP5K1A/FCGR2B/ACTR2/PTPRC/ARPC5/PIK3CA/PLA2G6/SYK/PRKCB/VAV2/PLA2G4A/PIP5K1B/PIK3CB/PRKCD/ASAP1/PLPP3/MARCKSL1/RAC1/MAPK1/PRKCE/PLA2G4C/BIN1/VAV1/RAC2/ACTR3/LAT/PAK1/PIK3R1/PLD1/PLCG1	34
KEGG	hsa04657	IL-17 signaling pathway	33/1759	94/8135	0.00176	0.0147	0.01061	CXCL10/MAPK9/TAB2/MAPK14/TRAF6/FOSB/IL13/MUC5AC/JUN/MAPK4/IL17RC/CSF2/MAP3K7/FOS/FADD/CASP3/IL17B/PTGS2/TBK1/HSP90AA1/IL5/TRAF3/USP25/MAPK1/JUND/MMP1/IL6/TRAF5/TRADD/NFKB1/MMP13/IFNG/MAPK8	33
KEGG	hsa04114	Oocyte meiosis	43/1759	131/8135	0.001836	0.01496	0.01079	PRKACB/PTTG1/FBXW11/MAPK14/RBX1/ADCY6/MAD2L1/CCNB1/ADCY7/CCNE2/PPP2CB/SMC1A/SPDYE2/YWHAZ/ITPR2/RPS6KA1/CDK1/CCNB2/YWHAH/AR/CDC20/PPP1CA/CDC16/AURKA/CPEB3/PPP2R5C/ADCY1/MAPK1/ITPR1/PPP2R1A/CCNE1/PPP3CC/PPP2CA/PPP2R1B/PPP3CB/CDC23/CALML3/CALM1/CAMK2B/MAD1L1/REC8/ADCY8/PRKACA	43
KEGG	hsa04930	Type II diabetes mellitus	19/1759	46/8135	0.002014	0.01602	0.01156	MAPK9/SOCS3/PRKCZ/PIK3CA/CACNA1B/PIK3CB/PRKCD/SLC2A2/GCK/MAPK1/PRKCE/ABCC8/CACNA1E/PKLR/PDX1/IRS2/MAPK8/PIK3R1/SOCS2	19
KEGG	hsa04210	Apoptosis	44/1759	136/8135	0.00225	0.0171	0.01234	MAPK9/AKT2/FAS/BCL2L1/ATM/TNFSF10/BIRC3/PARP1/GADD45B/JUN/CTSW/PARP2/PIK3CA/TRAF1/CSF2RB/TNFRSF10B/PIK3CB/PARP4/CTSC/ITPR2/PRF1/FOS/FADD/CASP3/CTSH/NTRK1/TUBA8/MCL1/CTSO/TP53/NRAS/DIABLO/MAPK1/TUBA1A/PIDD1/ITPR1/TNFRSF1A/BAK1/ERN1/TRADD/NFKB1/MAPK8/PIK3R1/AIFM1	44
KEGG	hsa05163	Human cytomegalovirus infection	67/1759	225/8135	0.002272	0.0171	0.01234	PRKACB/AKT2/FAS/GNAI3/TAP1/CCR5/CTNNB1/CCL5/MAPK14/PTGER1/ADCY6/GNG3/IL1R1/AKAP13/PIK3CA/ADCY7/PXN/PRKCB/PIK3CB/E2F3/ITPR2/NFATC4/FADD/CASP3/PTGS2/HLA-F/ITGB3/TAPBP/TBK1/CDKN1A/ROCK1/IL10RB/IL10RA/JAK1/EGFR/CXCR4/GNA11/CREB3/TP53/GNAI2/NRAS/RAC1/ADCY1/MAPK1/MYC/IFNA1/HLA-C/ITPR1/PPP3CC/RHEB/GNB3/TNFRSF1A/BAK1/PPP3CB/IL6/B2M/TRAF5/CALML3/CALM1/HLA-G/TRADD/ADCY8/RAC2/NFKB1/PIK3R1/PRKACA/ATF6B	67
KEGG	hsa04640	Hematopoietic cell lineage	34/1759	99/8135	0.002304	0.0171	0.01234	CD38/IL1R1/CD3E/HLA-DOB/EPOR/CD8A/CD2/CD3D/ITGA4/CD3G/CSF2/MS4A1/CSF1R/ITGB3/IL7/CD19/HLA-DMB/IL5/DNTT/IL7R/HLA-DPB1/CR1/FLT3LG/CSF1/HLA-DPA1/IL6/CD37/CD5/HLA-DMA/IL11/EPO/GP9/CD14/HLA-DQB1	34
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	31/1759	89/8135	0.002748	0.01974	0.01424	JAK2/AKT2/STAT1/MAPK14/TRAF6/JUN/LCK/PIK3CA/CD3E/RASGRP1/CD3D/PRKCQ/CD3G/PIK3CB/ALK/FOS/NFKBIE/CD247/JAK1/EGFR/PTPN6/NRAS/MAPK1/IFNGR2/PPP3CC/PPP3CB/NFKB1/LAT/IFNG/PIK3R1/PLCG1	31
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	34/1759	100/8135	0.002781	0.01974	0.01424	JAK2/MAPK9/PLCG2/EGR1/AKT2/STAT1/MAPK14/TGFBR2/PRKCZ/JUN/PIK3CA/PRKCB/STAT5A/AGT/PIK3CB/SMAD2/CASP3/TGFB2/PRKCD/FN1/NRAS/RAC1/MAPK1/PRKCE/NOX4/THBD/CDKN1B/IL6/PLCD1/NFKB1/MAPK8/PIK3R1/PLCG1/COL4A3	34
KEGG	hsa04625	C-type lectin receptor signaling pathway	35/1759	104/8135	0.002948	0.01974	0.01424	IRF9/MAPK9/PLCG2/MALT1/AKT2/STAT1/MAPK14/JUN/PIK3CA/SYK/CASP1/PIK3CB/NFKB2/ITPR2/NFATC4/PTGS2/PRKCD/IL10/NRAS/MAPK1/ITPR1/PPP3CC/PPP3CB/IL6/RRAS/CALML3/CALM1/EGR3/NFKB1/PAK1/PYCARD/MAPK8/PIK3R1/IL23A/CLEC1B	35
KEGG	hsa04912	GnRH signaling pathway	32/1759	93/8135	0.002952	0.01974	0.01424	MAPK9/PRKACB/EGR1/MAP2K7/MAPK14/ADCY6/JUN/ADCY7/PRKCB/PLA2G4A/MAP2K4/ITPR2/MMP14/PRKCD/EGFR/CACNA1S/GNA11/NRAS/ADCY1/MAPK1/ITPR1/PLA2G4C/FSHB/CALML3/CALM1/CAMK2B/GNRH2/ADCY8/MAPK8/PRKACA/PLD1/MAP3K2	32
KEGG	hsa04664	Fc epsilon RI signaling pathway	25/1759	68/8135	0.003011	0.01974	0.01424	MAPK9/PLCG2/AKT2/MAP2K7/MAPK14/IL13/PIK3CA/SYK/VAV2/PLA2G4A/PIK3CB/MAP2K4/CSF2/BTK/IL5/NRAS/RAC1/MAPK1/PLA2G4C/VAV1/RAC2/LAT/MAPK8/PIK3R1/PLCG1	25
KEGG	hsa04071	Sphingolipid signaling pathway	39/1759	119/8135	0.003014	0.01974	0.01424	MAPK9/AKT2/GNAI3/SGPP1/MAPK14/CERS6/PRKCZ/PIK3CA/PPP2CB/PRKCB/SPTLC3/PIK3CB/SGPL1/SMPD2/ROCK1/S1PR5/PPP2R5C/TP53/GNAI2/NRAS/RAC1/SPTLC2/MAPK1/PRKCE/PPP2R1A/ADORA1/TNFRSF1A/PPP2CA/SMPD1/PPP2R1B/CERS4/TRADD/RAC2/NFKB1/OPRD1/MAPK8/PIK3R1/PLD1/ADORA3	39
KEGG	hsa05210	Colorectal cancer	30/1759	86/8135	0.00311	0.01997	0.01441	MAPK9/AKT2/CTNNB1/MLH1/TGFBR2/LEF1/GADD45B/JUN/PIK3CA/MSH2/PIK3CB/SMAD2/DDB2/FOS/CASP3/TGFB2/CDKN1A/EGFR/ARAF/TP53/NRAS/EREG/RAC1/MAPK1/MYC/BAK1/AREG/RAC2/MAPK8/PIK3R1	30
KEGG	hsa05202	Transcriptional misregulation in cancer	58/1759	193/8135	0.003467	0.02185	0.01577	BCL2L1/NCOR1/ATM/FUT8/SS18/BIRC3/NSD2/TAF15/TGFBR2/FUS/HHEX/GADD45B/RXRB/CCNA2/ID2/TRAF1/FLI1/CCNT1/MLLT1/CDK9/BAIAP3/CSF2/DDB2/RUNX2/DEFA6/CD40/CSF1R/HOXA11/IL2RB/PTCRA/CD86/NTRK1/CDKN1A/TMPRSS2/NR4A3/MLLT3/MAX/TFE3/TP53/MYC/PBX3/BCL11B/ELANE/ITGB7/CDKN1B/REL/BAK1/IL6/ZEB1/PDGFA/ZBTB17/BCL6/PLAU/ETV1/NFKB1/HDAC1/CCNT2/CD14	58
KEGG	hsa05205	Proteoglycans in cancer	61/1759	205/8135	0.003552	0.02197	0.01585	PLCG2/PRKACB/FGFR1/AKT2/FAS/CTNNB1/MAPK14/PPP1R12A/EZR/FZD2/SDC1/PIK3CA/PXN/PRKCB/VAV2/WNT7A/GPC1/PIK3CB/SMAD2/ITPR2/FRS2/FZD3/FLNB/CASP3/TGFB2/ITGB3/WNT5A/CDKN1A/ROCK1/SHH/PPP1CA/TIMP3/EGFR/ARAF/FZD9/IHH/FN1/HSPG2/PTPN6/FZD1/TP53/NRAS/RAC1/MAPK1/IQGAP1/MYC/DROSHA/ITPR1/NANOG/WNT6/VAV1/RRAS/CAMK2B/PLAU/RPS6/PAK1/PIK3R1/PRKACA/PLCG1/WNT1/FZD6	61
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	33/1759	98/8135	0.003784	0.02298	0.01658	MAPK9/PLCG2/PRKACB/MAPK14/ADCY6/IL1R1/TRPV2/PIK3CA/PLA2G6/ADCY7/PRKCB/PLA2G4A/PRKCQ/PIK3CB/ITPR2/PRKCH/NTRK1/PRKCD/PPP1CA/ASIC1/ADCY1/PRKCE/ITPR1/PLA2G4C/P2RY2/CALML3/CALM1/CAMK2B/ADCY8/MAPK8/PIK3R1/PRKACA/PLCG1	33
KEGG	hsa03250	Viral life cycle - HIV-1	23/1759	63/8135	0.004798	0.02862	0.02065	CCR5/TSG101/XPO1/CCNT1/PSIP1/APOBEC3G/MLLT1/CDK9/APOBEC3B/KAT2B/APOBEC3C/MLLT3/MX1/CXCR4/CREBBP/MX2/NELFB/PDCD6IP/SUPT4H1/TRIM5/FURIN/ELL3/CCNT2	23
KEGG	hsa04012	ErbB signaling pathway	29/1759	85/8135	0.005192	0.03042	0.02196	MAPK9/PLCG2/AKT2/MAP2K7/PAK2/NCK1/JUN/PIK3CA/PRKCB/STAT5A/PAK3/PIK3CB/MAP2K4/CDKN1A/EGFR/ARAF/NRAS/EREG/MAPK1/MYC/CDKN1B/BTC/AREG/CAMK2B/SHC1/PAK1/MAPK8/PIK3R1/PLCG1	29
KEGG	hsa05323	Rheumatoid arthritis	31/1759	93/8135	0.005815	0.03349	0.02417	IL15/ATP6V1D/CCL5/ATP6V1H/JUN/ATP6V0E1/HLA-DOB/ATP6V1E1/CSF2/ITGB2/FOS/ATP6V1A/TGFB2/CD86/HLA-DMB/CTLA4/ATP6AP1/HLA-DPB1/IL18/CSF1/MMP1/HLA-DPA1/ATP6V1B1/IL6/HLA-DMA/IL11/IFNG/IL23A/LTB/ITGAL/HLA-DQB1	31
KEGG	hsa03460	Fanconi anemia pathway	20/1759	54/8135	0.006876	0.03835	0.02768	RMI1/HES1/MLH1/FANCF/RPA3/CENPX/PALB2/BLM/BRCA2/TOP3A/RPA4/RPA2/TOP3B/FANCG/FANCL/RPA1/USP1/POLI/FANCI/REV3L	20
KEGG	hsa04144	Endocytosis	71/1759	251/8135	0.006889	0.03835	0.02768	RAB35/FOLR1/CCR5/ARFGEF1/STAMBP/RAB8A/VPS35/SNX6/PIP5K1A/TSG101/TRAF6/TGFBR2/RAB11FIP3/PRKCZ/IL2RG/ACTR2/ARPC5/LDLR/SNX4/ZFYVE9/WASHC3/SH3GLB1/PIP5K1B/GRK2/FGFR4/EPN1/WASHC2C/RAB11A/SMAD2/CYTH3/CYTH1/WASHC5/IL2RB/HLA-F/STAM2/GIT2/VPS45/EGFR/CXCR4/ASAP1/SNF8/GRK1/WASL/EPS15/EHD3/SMAP1/HLA-C/GRK3/AGAP2/BIN1/WIPF1/EHD4/USP8/ACAP2/LDLRAP1/ZFYVE16/RAB22A/HSPA1L/PSD/ARFGAP2/HLA-G/ACTR3/PDCD6IP/CBLC/ACAP1/CHMP7/VPS37C/GRK6/PLD1/GIT1/SH3GLB2	71
KEGG	hsa05212	Pancreatic cancer	26/1759	76/8135	0.007577	0.04025	0.02905	MAPK9/AKT2/BCL2L1/STAT1/TGFBR2/GADD45B/PIK3CA/PIK3CB/E2F3/SMAD2/DDB2/BRCA2/TGFB2/CDKN1A/JAK1/EGFR/ARAF/TP53/RAC1/MAPK1/BAK1/RAC2/NFKB1/MAPK8/PIK3R1/PLD1	26
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	34/1759	106/8135	0.007779	0.04025	0.02905	PRKACB/FGFR1/EGR1/GNAI3/LRP6/ADCY6/RXRB/AKAP13/ADCY7/PRKCB/NR4A2/ITPR2/MMP14/RUNX2/FOS/PDE4B/CDKN1A/CYP24A1/EGFR/ARAF/GNA11/CREB3/GNAI2/ADCY1/MAPK1/ITPR1/JUND/TRPV5/NACA/ADCY8/MMP13/PRKACA/PLD1/ATF6B	34
KEGG	hsa05171	Coronavirus disease - COVID-19	66/1759	232/8135	0.007819	0.04025	0.02905	IRF9/CXCL10/MAPK9/PLCG2/IFIH1/TAB2/RPL37A/STAT1/MAPK14/TRAF6/OAS2/JUN/TLR3/RPL35A/PIK3CA/SYK/PRKCB/CASP1/IL6ST/TLR8/PIK3CB/RPS23/C7/CSF2/MAP3K7/RPS12/RPL9/IFNAR1/TLR7/FOS/RPS4Y1/C8G/TBK1/TMPRSS2/MASP1/MX1/JAK1/RPS5/DDX58/EGFR/RPL41/TRAF3/MAPK1/RPL39/IFNA1/RPS8/MX2/RPL18/MMP1/TNFRSF1A/RPL7/OAS1/IFNAR2/IL6/C3AR1/RPS28/NFKB1/RPS6/ADAR/MAPK8/PIK3R1/RPL38/RPS2/PLCG1/FGG/RPS27L	66
KEGG	hsa05152	Tuberculosis	53/1759	180/8135	0.007893	0.04025	0.02905	JAK2/MAPK9/MALT1/RFX5/AKT2/STAT1/FCGR2B/MAPK14/RIPK2/TRAF6/ATP6V1H/HLA-DOB/SYK/ITGB2/FADD/CASP3/TGFB2/IL10RB/RFXANK/IL10RA/NOD2/JAK1/NFYB/HLA-DMB/IL10/CREBBP/MAPK1/IFNGR2/IFNA1/ATP6AP1/PPP3CC/HLA-DPB1/IL18/CR1/CAMP/HLA-DPA1/TNFRSF1A/CORO1A/PPP3CB/IL6/HLA-DMA/CALML3/CALM1/CAMK2B/TRADD/LAMP1/NFKB1/IFNG/MAPK8/IL23A/CD74/CD14/HLA-DQB1	53
KEGG	hsa04621	NOD-like receptor signaling pathway	54/1759	184/8135	0.007919	0.04025	0.02905	GABARAPL1/IRF9/MAPK9/AIM2/GBP2/BCL2L1/MFN2/GBP1/TAB2/STAT1/BIRC3/CCL5/MAPK14/RIPK2/TRAF6/OAS2/JUN/TRPV2/VDAC3/CASP1/GSDMD/MAP3K7/ITPR2/IFNAR1/RBCK1/DEFA6/FADD/TBK1/BRCC3/HSP90AA1/ATG5/PRKCD/MFN1/NOD2/JAK1/TRAF3/MAPK1/IFNA1/ITPR1/RNASEL/IL18/CAMP/OAS1/IFNAR2/PSTPIP1/IL6/TRAF5/TXN2/NFKB1/ATG16L1/IRF7/PYCARD/MAPK8/PKN1	54
KEGG	hsa04062	Chemokine signaling pathway	56/1759	192/8135	0.007953	0.04025	0.02905	JAK2/CXCL10/PLCG2/PRKACB/CXCL9/AKT2/CXCL13/GNAI3/CCR5/STAT1/CCL18/CCL5/ELMO1/CXCL11/PRKCZ/ADCY6/GNG3/PIK3CA/ADCY7/PXN/PRKCB/XCL1/VAV2/GRK2/PIK3CB/ITK/PIK3R5/CCL1/CCR2/ROCK1/PRKCD/CCL13/JAK3/CXCR4/GRK1/DOCK2/GNAI2/NRAS/RAC1/ADCY1/MAPK1/GRK3/CCR7/GNB3/VAV1/SHC1/ADCY8/RAC2/NFKB1/PAK1/GRK6/PIK3R1/PRKACA/FGR/GSK3A/PLCG1	56
KEGG	hsa05226	Gastric cancer	45/1759	149/8135	0.008437	0.04206	0.03036	AKT2/CTNNB1/MLH1/LRP6/TGFBR2/LEF1/FGF21/GADD45B/RXRB/FZD2/PIK3CA/CCNE2/WNT7A/PIK3CB/E2F3/TERT/SMAD2/FZD3/DDB2/CTNNA1/TGFB2/WNT5A/CDKN1A/FGF5/SHH/FRAT1/EGFR/ARAF/FZD9/FZD1/TP53/NRAS/MAPK1/MUC2/MYC/CCNE1/CDKN1B/WNT6/FGF17/BAK1/SHC1/PIK3R1/ABCB1/WNT1/FZD6	45
KEGG	hsa05310	Asthma	13/1759	31/8135	0.008619	0.04233	0.03055	IL13/HLA-DOB/CD40/HLA-DMB/IL10/IL5/HLA-DPB1/HLA-DPA1/CD40LG/PRG2/EPX/HLA-DMA/HLA-DQB1	13
KEGG	hsa05222	Small cell lung cancer	30/1759	92/8135	0.009301	0.04502	0.03249	AKT2/BCL2L1/BIRC3/TRAF6/GADD45B/RXRB/PIK3CA/CCNE2/TRAF1/PIK3CB/E2F3/DDB2/CASP3/PTGS2/CDKN1A/LAMC3/FN1/MAX/TRAF3/TP53/CKS2/MYC/CCNE1/CDKN1B/BAK1/TRAF5/ZBTB17/NFKB1/PIK3R1/COL4A3	30
KEGG	hsa04931	Insulin resistance	34/1759	108/8135	0.01058	0.05049	0.03644	MAPK9/AKT2/SOCS3/PRKCZ/PIK3CA/PRKCB/MLXIP/AGT/PRKCQ/PTPRF/PIK3CB/RPS6KA1/PRKCD/PPP1CA/SLC2A2/CREB3/G6PC3/PTPN1/PRKCE/NR1H3/TBC1D4/GFPT1/TNFRSF1A/GYS1/IL6/SLC27A3/MLXIPL/IRS2/CPT1A/ACACB/NFKB1/MAPK8/PIK3R1/PRKAA2	34
KEGG	hsa04672	Intestinal immune network for IgA production	18/1759	49/8135	0.01107	0.05205	0.03757	IL15/IL15RA/HLA-DOB/TNFRSF17/ITGA4/CD40/CD86/CXCR4/HLA-DMB/IL10/IL5/ITGB7/HLA-DPB1/HLA-DPA1/CD40LG/IL6/HLA-DMA/HLA-DQB1	18
KEGG	hsa04611	Platelet activation	38/1759	124/8135	0.01147	0.05322	0.03841	PLCG2/PRKACB/AKT2/GNAI3/MAPK14/PPP1R12A/PRKCZ/ADCY6/PIK3CA/ADCY7/SYK/RASGRP1/GUCY1B1/PLA2G4A/VAMP8/PIK3CB/ITPR2/PIK3R5/APBB1IP/ITGB3/ROCK1/PPP1CA/BTK/GNAI2/ADCY1/MAPK1/GP6/ITPR1/ARHGAP35/PLA2G4C/F2R/PRKG1/GP9/ADCY8/PIK3R1/PRKACA/SNAP23/FGG	38
KEGG	hsa05416	Viral myocarditis	21/1759	60/8135	0.01173	0.05368	0.03874	EIF4G1/HLA-DOB/SGCA/PRF1/ITGB2/CD40/CASP3/HLA-F/CD86/HLA-DMB/RAC1/HLA-C/HLA-DPB1/EIF4G3/HLA-DPA1/CD40LG/HLA-DMA/HLA-G/RAC2/ITGAL/HLA-DQB1	21
KEGG	hsa04914	Progesterone-mediated oocyte maturation	32/1759	102/8135	0.01357	0.06127	0.04422	MAPK9/PRKACB/AKT2/GNAI3/MAPK14/ADCY6/MAD2L1/CCNA2/PIK3CA/CCNB1/ADCY7/SPDYE2/PIK3CB/RPS6KA1/STK10/CDK1/CCNB2/HSP90AA1/CDC25B/CDC16/ARAF/AURKA/CPEB3/GNAI2/ADCY1/MAPK1/CDC23/MAD1L1/ADCY8/MAPK8/PIK3R1/PRKACA	32
KEGG	hsa04927	Cortisol synthesis and secretion	22/1759	65/8135	0.01527	0.06799	0.04907	PRKACB/CACNA1I/ADCY6/LDLR/ADCY7/KCNK3/AGT/NR5A1/ITPR2/KCNK2/CACNA1S/GNA11/CREB3/CYP17A1/ADCY1/NR4A1/ITPR1/CACNA1H/ADCY8/PRKACA/PDE8A/ATF6B	22
KEGG	hsa04920	Adipocytokine signaling pathway	23/1759	69/8135	0.01612	0.07083	0.05112	JAK2/MAPK9/AKT2/SOCS3/ACSL5/AGRP/RXRB/PRKCQ/STK11/NFKBIE/TNFRSF1B/G6PC3/ADIPOR1/ACSL6/ACSL3/TNFRSF1A/IRS2/CPT1A/ACACB/TRADD/NFKB1/MAPK8/PRKAA2	23
KEGG	hsa04115	p53 signaling pathway	24/1759	73/8135	0.01689	0.07327	0.05288	FAS/BCL2L1/ATM/CHEK1/ZMAT3/RRM2/GADD45B/CCND3/CCNB1/CCNE2/TNFRSF10B/PPM1D/DDB2/CDK1/CASP3/CDKN1A/CCNB2/TP53/PIDD1/STEAP3/CCNE1/RPRM/SIAH1/CCNG2	24
KEGG	hsa05216	Thyroid cancer	14/1759	37/8135	0.01802	0.07718	0.0557	CTNNB1/TPR/LEF1/GADD45B/RXRB/DDB2/TPM3/NTRK1/CDKN1A/TP53/NRAS/MAPK1/MYC/BAK1	14
KEGG	hsa04730	Long-term depression	20/1759	60/8135	0.02383	0.1004	0.07249	GNAI3/PPP2CB/PRKCB/GUCY1B1/PLA2G4A/RYR1/ITPR2/ARAF/GNA11/GNAI2/NRAS/MAPK1/ITPR1/PPP2R1A/PLA2G4C/PRKG1/PPP2CA/PPP2R1B/GNAZ/CRH	20
KEGG	hsa05417	Lipid and atherosclerosis	59/1759	215/8135	0.02406	0.1004	0.07249	JAK2/MAPK9/APOA1/AKT2/FAS/BCL2L1/MAP2K7/TAB2/TNFSF10/CCL5/MAPK14/TRAF6/JUN/RXRB/ABCG1/LDLR/PIK3CA/VAV2/CASP1/TNFRSF10B/PIK3CB/MAP2K4/MAP3K7/CD40/FOS/CASP3/TBK1/HSP90AA1/TRAF3/TP53/NRAS/RAC1/MAPK1/IFNA1/ITPR1/PPP3CC/NCF4/IL18/ERO1A/MMP1/TNFRSF1A/CD40LG/VAV1/PPP3CB/IL6/CALML3/CALM1/HSPA1L/CAMK2B/ERN1/NFKB1/IRF7/PYCARD/MAPK8/PIK3R1/LY96/PLCG1/APOA4/CD14	59
KEGG	hsa04270	Vascular smooth muscle contraction	39/1759	134/8135	0.02468	0.1018	0.07345	PRKACB/PPP1R12A/ADCY6/KCNMB1/PLA2G6/ADCY7/PRKCB/GUCY1B1/PLA2G4A/PLA2G2D/AGT/PRKCQ/ITPR2/PRKCH/MYL6/ROCK1/PRKCD/PLA2G2E/PPP1CA/ARAF/EDN2/CALCA/CACNA1S/AVP/GNA11/ADCY1/MAPK1/NPPB/PRKCE/ITPR1/PLA2G4C/ADM2/PRKG1/CALML3/CALM1/ADCY8/PLA2G12A/PRKACA/ADORA2B	39
KEGG	hsa04014	Ras signaling pathway	63/1759	232/8135	0.02511	0.1022	0.07376	MAPK9/PLCG2/PRKACB/FGFR1/AKT2/BCL2L1/EXOC2/PAK2/RGL1/FGF21/RASA1/GNG3/PIK3CA/PLA2G6/PRKCB/RASGRP1/PLA2G4A/PLA2G2D/FGFR4/PAK3/PIK3CB/RASA3/RASGRF1/NTRK2/AFDN/CSF1R/NTRK1/TBK1/FGF5/PLA2G2E/EGFR/PDGFC/NRAS/RAC1/MAPK1/NF1/PLA2G4C/ETS1/FLT3LG/CSF1/GNB3/FGF17/REL/EFNA5/PDGFA/ANGPT2/RRAS/BDNF/CALML3/CALM1/EFNA4/SHC1/RAC2/NFKB1/LAT/PLA2G12A/PAK1/MAPK8/PIK3R1/PRKACA/PLD1/PLCG1/RASA2	63
KEGG	hsa05332	Graft-versus-host disease	15/1759	42/8135	0.0254	0.1022	0.07376	FAS/HLA-DOB/PRF1/HLA-F/CD86/HLA-DMB/HLA-C/HLA-DPB1/HLA-DPA1/IL6/HLA-DMA/HLA-G/KLRD1/IFNG/HLA-DQB1	15
KEGG	hsa05320	Autoimmune thyroid disease	18/1759	53/8135	0.02575	0.1022	0.07378	FAS/HLA-DOB/PRF1/CD40/HLA-F/CD86/HLA-DMB/IL10/IL5/CTLA4/IFNA1/HLA-C/HLA-DPB1/HLA-DPA1/CD40LG/HLA-DMA/HLA-G/HLA-DQB1	18
KEGG	hsa04060	Cytokine-cytokine receptor interaction	78/1759	295/8135	0.02602	0.1022	0.07378	CXCL10/CXCL9/IL15/FAS/CXCL13/CCR5/IL15RA/CLCF1/IL32/OSM/TNFSF10/CCL18/CCL5/IL27RA/IL21R/CD27/TGFBR2/CXCL11/CTF1/IL2RG/IL13/LIF/IL1R1/CD70/TNFRSF17/EPOR/XCL1/IL1RL2/IL6ST/IL16/CSF2RB/TNFRSF10B/ACVRL1/IL17RC/CSF2/IFNAR1/TNFRSF10D/AMHR2/BMP10/CD40/CSF1R/IL2RB/TGFB2/IL17B/CCL1/CCR2/CSH1/TNFRSF1B/IL36G/IL7/IL10RB/GDF5/IL10RA/CCL13/CXCR4/TNFSF4/IL10/IL5/IL7R/BMP8A/IFNGR2/IFNA1/GDF15/CCR7/IL18/CSF1/TNFRSF1A/CD40LG/IFNAR2/IL6/INHBA/CNTFR/IL11/EPO/IFNG/IL23A/ACVR2A/LTB	78
KEGG	hsa04310	Wnt signaling pathway	47/1759	167/8135	0.02677	0.104	0.07505	MAPK9/PRKACB/CTNNB1/FBXW11/LRP6/RBX1/LEF1/TBL1X/JUN/CCND3/SFRP1/FZD2/PRKCB/TBL1XR1/WNT7A/VANGL1/MAP3K7/FZD3/NFATC4/NLK/WNT5A/CACYBP/FRAT1/FZD9/CREBBP/FZD1/TP53/RAC1/PSEN1/MYC/RNF43/PPP3CC/WNT6/ROR1/PPP3CB/SIAH1/TLE6/TLE2/CAMK2B/TBL1Y/RAC2/SFRP5/MAPK8/PRKACA/DAAM1/WNT1/FZD6	47
KEGG	hsa03050	Proteasome	16/1759	46/8135	0.02752	0.1057	0.07626	PSMB9/PSMB8/PSMB10/PSMC2/PSME1/PSMD3/PSMF1/PSMD4/PSMA5/PSMB4/PSMA4/PSMB7/PSMA2/PSMB5/IFNG/PSMD8	16
KEGG	hsa04540	Gap junction	27/1759	88/8135	0.02935	0.1114	0.08039	PRKACB/GNAI3/ADCY6/ADCY7/PRKCB/GUCY1B1/ITPR2/CDK1/GJD2/TUBA8/CSNK1D/EGFR/PDGFC/TUBB/GNA11/GNAI2/NRAS/ADCY1/MAPK1/TUBA1A/TUBB2A/ITPR1/PRKG1/PDGFA/ADCY8/PRKACA/MAP3K2	27
KEGG	hsa05211	Renal cell carcinoma	22/1759	69/8135	0.03055	0.1146	0.08274	CUL2/AKT2/PAK2/RBX1/RAPGEF1/EPAS1/JUN/PIK3CA/PAK3/PIK3CB/TGFB2/CDKN1A/ARAF/CREBBP/TFE3/NRAS/RAC1/EGLN3/MAPK1/ETS1/PAK1/PIK3R1	22
KEGG	hsa05131	Shigellosis	66/1759	247/8135	0.03103	0.1152	0.08311	MAPK9/PLCG2/MALT1/AKT2/BCL2L1/TNIP1/ATM/TAB2/FBXW11/CCL5/ELMO1/MAPK14/RIPK2/RBX1/TRAF6/JUN/ACTR2/IL1R1/ARPC5/PIK3CA/PXN/CASP1/FNBP1/PRKCQ/UBC/PIK3CB/CSF2/MAP3K7/CYTH3/CYTH1/ITPR2/PPID/MYL5/RBCK1/TBK1/ROCK1/ATG5/PRKCD/GLMN/SQSTM1/EGFR/WASL/CAST/TP53/RAC1/WIPI1/MAPK1/RPS6KA5/PRKCE/ITPR1/IL18/TNFRSF1A/TRAF5/TRADD/UBE2D4/PLCD1/RRAGC/ACTR3/NFKB1/ATG16L1/PYCARD/MAPK8/PIK3R1/GSK3A/PLCG1/CD14	66
KEGG	hsa04940	Type I diabetes mellitus	15/1759	43/8135	0.03143	0.1154	0.08326	FAS/HLA-DOB/PRF1/HLA-F/CD86/HLA-DMB/GAD2/HLA-C/HLA-DPB1/HLA-DPA1/HLA-DMA/PTPRN/HLA-G/IFNG/HLA-DQB1	15
KEGG	hsa05215	Prostate cancer	29/1759	97/8135	0.03437	0.1228	0.08866	FGFR1/AKT2/CTNNB1/LEF1/PIK3CA/CCNE2/PIK3CB/INSRR/E2F3/CDKN1A/TMPRSS2/HSP90AA1/AR/EGFR/PDGFC/ARAF/CREBBP/CREB3/TP53/NRAS/MAPK1/CCNE1/CDKN1B/ZEB1/PDGFA/KLK3/PLAU/NFKB1/PIK3R1	29
KEGG	hsa04151	PI3K-Akt signaling pathway	91/1759	354/8135	0.03456	0.1228	0.08866	JAK2/FGFR1/AKT2/BCL2L1/OSM/COL6A1/ITGB4/IL2RG/FGF21/CCND3/GNG3/PIK3CA/CCNE2/PPP2CB/SYK/EPOR/ITGA7/FGFR4/YWHAZ/ITGA4/PIK3CB/NTRK2/IFNAR1/TNXB/STK11/CSF1R/MAGI1/DDIT4/PIK3R5/IL2RB/CSH1/ITGB3/NTRK1/CDKN1A/FGF5/IL7/HSP90AA1/YWHAH/CD19/LAMC3/JAK1/JAK3/EGFR/PDGFC/MCL1/FN1/PPP2R5C/CREB3/TP53/SGK1/IL7R/NRAS/EREG/RAC1/G6PC3/MAPK1/NR4A1/MYC/IFNA1/PPP2R1A/CCNE1/ITGB7/CDKN1B/RHEB/F2R/FLT3LG/CSF1/GNB3/FGF17/PPP2CA/GYS1/PPP2R1B/IFNAR2/EFNA5/IL6/AREG/PDGFA/ANGPT2/BDNF/TCL1B/EFNA4/LPAR6/EPO/NFKB1/RPS6/THBS2/PIK3R1/PRKAA2/PKN1/COL4A3/ATF6B	91
KEGG	hsa04725	Cholinergic synapse	33/1759	113/8135	0.03494	0.1228	0.08866	JAK2/PRKACB/AKT2/GNAI3/KCNJ4/ADCY6/GNG3/PIK3CA/ADCY7/PRKCB/KCNJ2/CACNA1B/PIK3CB/ITPR2/FOS/PIK3R5/KCNQ4/CACNA1S/GNA11/CREB3/CHAT/GNAI2/NRAS/ADCY1/MAPK1/SLC18A3/ITPR1/GNB3/CAMK2B/ADCY8/PIK3R1/PRKACA/KCNQ3	33
KEGG	hsa04919	Thyroid hormone signaling pathway	35/1759	121/8135	0.03494	0.1228	0.08866	PLCG2/PRKACB/AKT2/NCOR1/CTNNB1/STAT1/DIO3/HDAC3/RXRB/PIK3CA/DIO2/PRKCB/MED17/PIK3CB/KAT2B/ITGB3/MED12/NCOA1/CREBBP/TP53/NRAS/MAPK1/MYC/RHEB/TBC1D4/ATP1B2/ATP1B3/PLCD1/ATP2A3/MED24/PIK3R1/PRKACA/THRA/PLCG1/HDAC1	35
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1759	70/8135	0.03574	0.1243	0.08974	MAPK9/PLCG2/ATP6V1D/ADAM10/CCL5/MAPK14/ATP6V1H/JUN/ATP6V0E1/ATP6V1E1/MAP2K4/CASP3/ATP6V1A/EGFR/RAC1/ATP6AP1/ATP6V1B1/NFKB1/PAK1/MAPK8/PLCG1/GIT1	22
KEGG	hsa04612	Antigen processing and presentation	24/1759	78/8135	0.03719	0.1281	0.09243	RFX5/TAP1/HLA-DOB/CD8A/PSME1/HLA-F/TAPBP/HSP90AA1/RFXANK/NFYB/HLA-DMB/LGMN/KIR2DS3/HLA-C/HLA-DPB1/HLA-DPA1/B2M/HLA-DMA/HSPA1L/HLA-G/KLRD1/IFNG/CD74/HLA-DQB1	24
KEGG	hsa04370	VEGF signaling pathway	19/1759	59/8135	0.03851	0.1292	0.09321	PLCG2/AKT2/MAPK14/PIK3CA/PXN/PRKCB/PLA2G4A/PIK3CB/PTGS2/NRAS/RAC1/MAPK1/PLA2G4C/PPP3CC/SH2D2A/PPP3CB/RAC2/PIK3R1/PLCG1	19
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	119/1759	476/8135	0.03853	0.1292	0.09321	MAPK9/FAS/BCL2L1/FIG4/MFN2/MAP2K7/RAB8A/CTNNB1/UBE2J1/NDUFA9/ACTR10/UBE2L6/ATP5PB/MAPK14/HAP1/LRP6/GRIN2C/FUS/OPTN/SPG11/PSMC2/UBE2G2/NDUFS3/NDUFS1/FZD2/VDAC3/PRKCB/CACNA1B/ATG2B/RYR1/WNT7A/APP/UBC/UBE2G1/ITPR2/PPID/FZD3/DCTN3/FADD/SNCA/CASP3/PTGS2/SDHA/PSMD3/WNT5A/TBK1/DNAH9/TNFRSF1B/TUBA8/UBE2L3/MFN1/FRAT1/TOMM40/TRAP1/ATXN3/SQSTM1/DNAL4/TUBB/ARAF/ATG13/FZD9/PSMD4/CACNA1S/PSMA5/FZD1/NRAS/NDUFS7/RAC1/DNAH17/WIPI1/MAPK1/PSMB4/TUBA1A/PSEN1/TUBB2A/SLC6A3/MAP3K10/NOX4/ITPR1/PSMA4/UQCRC1/PPP3CC/MAPT/WNT6/DNAH6/CSF1/TNFRSF1A/NDUFA8/CDK5/BAK1/PPP3CB/STX1A/IL6/PPIF/HIP1/PSMB7/BDNF/ATP5PD/CALML3/PSMA2/CALM1/DNAI1/CAMK2B/COX6A2/PSMB5/ERN1/SLC25A31/GPX3/ATXN2L/NFKB1/KLC1/ATP2A3/MAPK8/PSMD8/PLCG1/ATP5F1A/ULK1/WNT1/FZD6	119
KEGG	hsa04350	TGF-beta signaling pathway	28/1759	94/8135	0.03885	0.1292	0.09321	RBX1/TGFBR2/ZFYVE9/ID2/PPP2CB/SMAD6/CHRD/ID4/SMAD2/AMHR2/TGFB2/ROCK1/GDF5/CREBBP/MAPK1/BMP8A/LEFTY1/MYC/PPP2R1A/RBL1/E2F4/PPP2CA/PPP2R1B/ZFYVE16/INHBA/HAMP/IFNG/ACVR2A	28
KEGG	hsa04925	Aldosterone synthesis and secretion	29/1759	98/8135	0.03906	0.1292	0.09321	PRKACB/CACNA1I/ADCY6/LDLR/ADCY7/PRKCB/KCNK3/AGT/NR4A2/ITPR2/PRKD2/DAGLA/CACNA1S/GNA11/CREB3/ADCY1/NR4A1/PRKCE/ITPR1/ATP1B2/CACNA1H/ATP2B4/CALML3/CALM1/CAMK2B/ATP1B3/ADCY8/PRKACA/ATF6B	29
KEGG	hsa00310	Lysine degradation	20/1759	63/8135	0.0397	0.13	0.09382	SMYD2/NSD2/HADHA/DHTKD1/EHMT1/KMT5A/KMT5B/AASS/PRDM16/ASH1L/CAMKMT/EZH2/NSD1/SETD1A/SMYD3/PRDM2/PLOD3/NSD3/DLD/SUV39H2	20
KEGG	hsa04722	Neurotrophin signaling pathway	34/1759	119/8135	0.04389	0.1423	0.1027	MAPK9/PLCG2/AKT2/MAP2K7/MAPK14/RIPK2/RAPGEF1/TRAF6/JUN/PIK3CA/PIK3CB/NTRK2/FRS2/RPS6KA1/NFKBIE/NTRK1/PRKCD/ZNF274/TP53/NRAS/RAC1/MAPK1/RPS6KA5/PSEN1/ARHGDIB/BDNF/CALML3/CALM1/CAMK2B/SHC1/NFKB1/MAPK8/PIK3R1/PLCG1	34
KEGG	hsa05133	Pertussis	23/1759	76/8135	0.04862	0.1562	0.1127	MAPK9/GNAI3/MAPK14/TRAF6/JUN/CASP1/IRF8/ITGB2/FOS/CASP3/IL10/GNAI2/MAPK1/IL6/CALML3/CALM1/C4BPA/NFKB1/PYCARD/MAPK8/LY96/IL23A/CD14	23
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	10/1759	27/8135	0.04917	0.1564	0.1129	FUT4/B3GNT2/FUT3/B4GALT2/FUT5/ST8SIA1/B3GNT4/B3GALNT1/B4GALT1/FUT2	10
KEGG	hsa04921	Oxytocin signaling pathway	42/1759	154/8135	0.05532	0.1735	0.1252	PRKACB/GNAI3/CD38/KCNJ4/PPP1R12A/ADCY6/JUN/EEF2/ADCY7/PRKCB/KCNJ2/GUCY1B1/PLA2G4A/RYR1/CACNG2/ITPR2/NFATC4/FOS/PIK3R5/PTGS2/CDKN1A/MYL6/ROCK1/PPP1CA/CACNG5/CACNG1/EGFR/CACNA1S/GNAI2/NRAS/ADCY1/MAPK1/ITPR1/PLA2G4C/PPP3CC/PPP3CB/CALML3/CALM1/CAMK2B/ADCY8/PRKAA2/PRKACA	42
KEGG	hsa04916	Melanogenesis	29/1759	101/8135	0.05598	0.1735	0.1252	PRKACB/GNAI3/CTNNB1/LEF1/ADCY6/FZD2/ADCY7/PRKCB/WNT7A/EDNRB/FZD3/WNT5A/FZD9/CREBBP/CREB3/FZD1/GNAI2/NRAS/ADCY1/MAPK1/WNT6/TYRP1/CALML3/CALM1/CAMK2B/ADCY8/PRKACA/WNT1/FZD6	29
KEGG	hsa04024	cAMP signaling pathway	58/1759	221/8135	0.0561	0.1735	0.1252	MAPK9/PRKACB/AKT2/GNAI3/ABCC4/GRIN2C/PPP1R12A/ADCY6/VIPR2/JUN/PIK3CA/ADCY7/VAV2/SSTR1/PIK3CB/HTR6/AFDN/FOS/PDE4B/ROCK1/PPP1CA/EDN2/CREBBP/CACNA1S/SOX9/CREB3/GNAI2/RAC1/ADCY1/MAPK1/ADORA1/GHSR/F2R/ATP1B2/GLI1/ADCYAP1R1/GIPR/SSTR2/VAV1/ATP2B4/FSHB/RRAS/BDNF/CALML3/CALM1/CAMK2B/ATP1B3/CRH/ADCY8/RAC2/NFKB1/ATP2A3/PAK1/MAPK8/PIK3R1/PRKACA/GIP/PLD1	58
KEGG	hsa05213	Endometrial cancer	18/1759	58/8135	0.06044	0.1852	0.1337	AKT2/CTNNB1/MLH1/LEF1/GADD45B/PIK3CA/PIK3CB/DDB2/CTNNA1/CDKN1A/EGFR/ARAF/TP53/NRAS/MAPK1/MYC/BAK1/PIK3R1	18
KEGG	hsa05130	Pathogenic Escherichia coli infection	52/1759	197/8135	0.06179	0.1862	0.1344	MAPK9/FAS/TAB2/PAK2/TNFSF10/MAPK14/TRAF6/NCK1/EZR/ABI1/JUN/ACTR2/IL1R1/ARPC5/CYFIP2/CASP1/TNFRSF10B/PAK3/MAP3K7/CYTH3/CYTH1/TMED10/CLDN11/BAIAP2/FOS/FADD/CASP3/ROCK1/MYO5A/TUBA8/TUBB/WASL/SEC24A/PTPN6/RAC1/MAPK1/TUBA1A/TUBB2A/IL18/F2R/TNFRSF1A/WIPF1/BAK1/MYO1A/IL6/TRADD/SEC24B/ACTR3/NFKB1/PAK1/PYCARD/MAPK8	52
KEGG	hsa05224	Breast cancer	40/1759	147/8135	0.06216	0.1862	0.1344	FGFR1/AKT2/HES1/CTNNB1/LRP6/LEF1/FGF21/GADD45B/JUN/FZD2/PIK3CA/HEYL/WNT7A/PIK3CB/NFKB2/E2F3/FZD3/DDB2/BRCA2/FOS/WNT5A/CDKN1A/FGF5/NCOA1/FRAT1/EGFR/ARAF/FZD9/FZD1/TP53/NRAS/MAPK1/MYC/WNT6/FGF17/BAK1/SHC1/PIK3R1/WNT1/FZD6	40
KEGG	hsa04917	Prolactin signaling pathway	21/1759	70/8135	0.06274	0.1862	0.1344	JAK2/MAPK9/AKT2/SOCS3/STAT1/MAPK14/PIK3CA/STAT5A/TH/PIK3CB/FOS/SLC2A2/GCK/CYP17A1/NRAS/MAPK1/SHC1/NFKB1/MAPK8/PIK3R1/SOCS2	21
KEGG	hsa04911	Insulin secretion	25/1759	86/8135	0.06349	0.1862	0.1344	PRKACB/ADCY6/KCNMB1/KCNN4/ADCY7/PRKCB/KCNN2/KCNN3/SLC2A2/CACNA1S/GCK/GNA11/CREB3/ADCY1/ATP1B2/ABCC8/ADCYAP1R1/STX1A/PDX1/CAMK2B/ATP1B3/ADCY8/PRKACA/GIP/ATF6B	25
KEGG	hsa04015	Rap1 signaling pathway	55/1759	210/8135	0.06357	0.1862	0.1344	FGFR1/AKT2/GNAI3/CTNNB1/MAPK14/RAPGEF1/PRKCZ/ADCY6/FGF21/PIK3CA/ADCY7/PRKCB/EVL/VAV2/FGFR4/SIPA1/RAP1GAP/PIK3CB/ITGB2/AFDN/PRKD2/CSF1R/MAGI1/APBB1IP/RAPGEF6/ITGB3/FGF5/CNR1/SKAP1/EGFR/PDGFC/GNAI2/NRAS/RAC1/ADCY1/MAPK1/FYB1/F2R/CSF1/FGF17/EFNA5/VAV1/PDGFA/ANGPT2/RRAS/CALML3/CALM1/EFNA4/ADCY8/RAC2/LAT/PIK3R1/PLCG1/ITGAL/ADORA2B	55
KEGG	hsa04068	FoxO signaling pathway	36/1759	131/8135	0.06524	0.1895	0.1368	GABARAPL1/MAPK9/AKT2/ATM/TNFSF10/MAPK14/TGFBR2/GADD45B/PIK3CA/CCNB1/PIK3CB/STK11/TGFB2/NLK/CDKN1A/CCNB2/EGFR/ARAF/IL10/CREBBP/SGK1/PLK2/IL7R/NRAS/G6PC3/MAPK1/AGAP2/CDKN1B/IL6/IRS2/BCL6/MAPK8/PIK3R1/PRKAA2/CDKN2D/CCNG2	36
KEGG	hsa04330	Notch signaling pathway	18/1759	59/8135	0.07007	0.1998	0.1442	HES1/HEYL/RBPJL/MFNG/KAT2B/PTCRA/RBPJ/CREBBP/PSEN1/CIR1/NCOR2/TLE6/TLE2/LFNG/MAML3/MAML1/DTX3/HDAC1	18
KEGG	hsa04623	Cytosolic DNA-sensing pathway	19/1759	63/8135	0.0708	0.1998	0.1442	CXCL10/AIM2/POLR2F/CCL5/CASP1/TBK1/POLR3B/DDX58/IFNA1/POLR3K/IL18/IL6/POLR3G/POLR2E/POLR1D/NFKB1/ADAR/IRF7/PYCARD	19
KEGG	hsa05217	Basal cell carcinoma	19/1759	63/8135	0.0708	0.1998	0.1442	CTNNB1/LEF1/GADD45B/FZD2/WNT7A/FZD3/DDB2/WNT5A/CDKN1A/SHH/FZD9/FZD1/TP53/WNT6/GLI1/BAK1/PTCH2/WNT1/FZD6	19
KEGG	hsa04142	Lysosome	36/1759	132/8135	0.07172	0.1998	0.1442	AP3D1/ATP6V1H/WDR7/AP1S2/CTSW/AGA/GM2A/GNPTAB/AP1S1/CLN5/ABCA2/CTSC/AP3B1/CTSH/ACP2/CTSG/LAMP3/SLC11A1/NAGA/DMXL1/LGMN/MAN2B1/CTSO/ATP6AP1/AP3S1/TPP1/SMPD1/IDS/HEXB/LAMP1/AP3B2/GGA3/CTNS/ABCB9/LAPTM4A/SCARB2	36
KEGG	hsa05214	Glioma	22/1759	75/8135	0.07179	0.1998	0.1442	PLCG2/AKT2/GADD45B/PIK3CA/PRKCB/PIK3CB/E2F3/DDB2/CDKN1A/EGFR/ARAF/TP53/NRAS/MAPK1/BAK1/PDGFA/CALML3/CALM1/CAMK2B/SHC1/PIK3R1/PLCG1	22
KEGG	hsa00061	Fatty acid biosynthesis	7/1759	18/8135	0.07362	0.2032	0.1467	ACSL5/OXSM/ACSL6/FASN/ACSL3/MECR/ACACB	7
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/1759	100/8135	0.07833	0.2139	0.1544	CXCL10/CXCL9/CXCL13/CCR5/TNFSF10/CCL18/CCL5/CXCL11/IL2RG/XCL1/IL6ST/TNFRSF10B/TNFRSF10D/CSF1R/IL2RB/CCL1/CCR2/TNFRSF1B/IL10RB/IL10RA/CCL13/CXCR4/IL10/CCR7/IL18/CSF1/TNFRSF1A/IL6	28
KEGG	hsa04926	Relaxin signaling pathway	35/1759	129/8135	0.07973	0.2139	0.1544	MAPK9/PRKACB/AKT2/GNAI3/MAP2K7/MAPK14/TGFBR2/PRKCZ/ADCY6/JUN/GNG3/PIK3CA/ADCY7/PIK3CB/MAP2K4/EDNRB/SMAD2/FOS/EGFR/CREB3/GNAI2/NRAS/ADCY1/MAPK1/GNB3/MMP1/SHC1/ADCY8/NFKB1/MMP13/MAPK8/PIK3R1/PRKACA/COL4A3/ATF6B	35
KEGG	hsa04923	Regulation of lipolysis in adipocytes	17/1759	56/8135	0.08	0.2139	0.1544	PRKACB/AKT2/GNAI3/ADCY6/PIK3CA/ADCY7/PNPLA2/PIK3CB/PTGS2/GNAI2/ADCY1/ADORA1/PRKG1/IRS2/ADCY8/PIK3R1/PRKACA	17
KEGG	hsa05220	Chronic myeloid leukemia	22/1759	76/8135	0.08122	0.2139	0.1544	AKT2/BCL2L1/TGFBR2/GADD45B/PIK3CA/STAT5A/PIK3CB/E2F3/DDB2/TGFB2/CDKN1A/ARAF/TP53/NRAS/MAPK1/MYC/CDKN1B/BAK1/SHC1/NFKB1/PIK3R1/HDAC1	22
KEGG	hsa04137	Mitophagy - animal	21/1759	72/8135	0.08135	0.2139	0.1544	GABARAPL1/MAPK9/BCL2L1/MFN2/OPTN/JUN/UBC/TBK1/ATG5/MFN1/SQSTM1/TBC1D15/TFE3/TP53/NRAS/TFEB/USP8/RRAS/MAPK8/RHOT1/ULK1	21
KEGG	hsa05223	Non-small cell lung cancer	21/1759	72/8135	0.08135	0.2139	0.1544	PLCG2/AKT2/GADD45B/RXRB/PIK3CA/PRKCB/STAT5A/PIK3CB/ALK/E2F3/DDB2/CDKN1A/JAK3/EGFR/ARAF/TP53/NRAS/MAPK1/BAK1/PIK3R1/PLCG1	21
KEGG	hsa04022	cGMP-PKG signaling pathway	44/1759	167/8135	0.08241	0.215	0.1552	AKT2/GNAI3/PPP1R12A/GTF2I/ADCY6/KCNMB1/VDAC3/ADCY7/GUCY1B1/GTF2IRD1/EDNRB/ITPR2/NFATC4/SRF/PIK3R5/ROCK1/ADRA2B/PPP1CA/CACNA1S/GNA11/CREB3/GNAI2/ADCY1/MAPK1/NPPB/PRKCE/ITPR1/ADORA1/PPP3CC/ATP1B2/PRKG1/PPP3CB/ATP2B4/PPIF/CALML3/CALM1/ATP1B3/IRS2/SLC25A31/ADCY8/ATP2A3/OPRD1/ATF6B/ADORA3	44
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/1759	15/8135	0.08416	0.2179	0.1573	SLC33A1/ST8SIA1/ST8SIA5/B3GALT4/HEXB/ST6GALNAC4	6
KEGG	hsa04216	Ferroptosis	13/1759	41/8135	0.0873	0.2243	0.1619	ACSL5/SLC3A2/VDAC3/SAT1/FTL/ATG5/TP53/HMOX1/ACSL6/STEAP3/ACSL3/SLC39A8/GSS	13
KEGG	hsa00565	Ether lipid metabolism	15/1759	49/8135	0.0905	0.23	0.166	PLA2G6/PAFAH1B1/GAL3ST1/PLA2G4A/PLA2G2D/PAFAH1B3/GDPD3/PLA2G2E/PLPP3/AGPS/PLA2G4C/LPCAT4/PAFAH1B2/PLA2G12A/PLD1	15
KEGG	hsa05017	Spinocerebellar ataxia	38/1759	143/8135	0.0909	0.23	0.166	MAPK9/AKT2/GRIN2C/PUM2/PSMC2/PIK3CA/VDAC3/PRKCB/ATG2B/RYR1/PIK3CB/RBPJL/ITPR2/OPA1/PSMD3/RBPJ/ATXN3/TWNK/ATG13/PSMD4/PSMA5/WIPI1/PSMB4/ITPR1/PSMA4/PPIF/GTF2B/PSMB7/PSMA2/PSMB5/ERN1/SLC25A31/ATXN2L/ATP2A3/MAPK8/PIK3R1/PSMD8/ULK1	38
KEGG	hsa01524	Platinum drug resistance	21/1759	73/8135	0.0919	0.2303	0.1662	AKT2/FAS/BCL2L1/ATM/MLH1/BIRC3/PIK3CA/MSH2/PIK3CB/XPA/FADD/CASP3/CDKN1A/TP53/MAPK1/TOP2A/SLC31A1/BAK1/REV3L/PIK3R1/TOP2B	21
KEGG	hsa04670	Leukocyte transendothelial migration	31/1759	114/8135	0.09239	0.2303	0.1662	PLCG2/GNAI3/CTNNB1/MAPK14/EZR/PIK3CA/PXN/PRKCB/VAV2/SIPA1/ITGA4/PIK3CB/ITGB2/CTNNA1/MYL5/AFDN/CLDN11/ITK/RHOH/ROCK1/TXK/CXCR4/GNAI2/RAC1/ARHGAP35/NCF4/VAV1/RAC2/PIK3R1/PLCG1/ITGAL	31
KEGG	hsa01523	Antifolate resistance	10/1759	30/8135	0.09429	0.2333	0.1684	GGH/FOLR1/ABCC4/SLC19A1/TYMS/ATIC/SHMT1/MTHFR/IL6/NFKB1	10
KEGG	hsa01522	Endocrine resistance	27/1759	98/8135	0.09728	0.2372	0.1712	MAPK9/PRKACB/AKT2/NCOR1/MAPK14/ADCY6/JUN/PIK3CA/ADCY7/PIK3CB/E2F3/FOS/CDKN1A/EGFR/ARAF/CYP2D6/TP53/NRAS/ADCY1/MAPK1/CDKN1B/BIK/SHC1/ADCY8/MAPK8/PIK3R1/PRKACA	27
KEGG	hsa05231	Choline metabolism in cancer	27/1759	98/8135	0.09728	0.2372	0.1712	MAPK9/AKT2/PIP5K1A/CHKA/JUN/PIK3CA/PRKCB/PLA2G4A/PIP5K1B/PIK3CB/FOS/DGKQ/EGFR/PDGFC/PLPP3/NRAS/RAC1/MAPK1/PLA2G4C/RHEB/SLC22A1/PDGFA/RAC2/MAPK8/PIK3R1/PLD1/PLCG1	27
KEGG	hsa04146	Peroxisome	23/1759	82/8135	0.1016	0.2459	0.1774	FAR2/PEX2/PEX11B/MVK/ACSL5/DECR2/GNPAT/PEX5/PEX3/IDH2/PAOX/NUDT7/PEX26/ACSL6/AGPS/GSTK1/ACSL3/PEX12/ABCD2/HAO2/MPV17/PEX1/HMGCL	23
KEGG	hsa05144	Malaria	15/1759	50/8135	0.1046	0.2492	0.1798	LRP1/SDC1/ITGB2/CD40/TGFB2/IL10/IL18/CR1/CD40LG/IL6/HBB/THBS2/IFNG/KLRB1/ITGAL	15
KEGG	hsa04213	Longevity regulating pathway - multiple species	18/1759	62/8135	0.1049	0.2492	0.1798	PRKACB/AKT2/ADCY6/PIK3CA/ADCY7/PIK3CB/CLPB/ATG5/NRAS/ADCY1/HSPA1L/IRS2/ADCY8/EIF4EBP2/PIK3R1/PRKAA2/PRKACA/HDAC1	18
KEGG	hsa04514	Cell adhesion molecules	39/1759	149/8135	0.1052	0.2492	0.1798	ALCAM/CADM3/PTPRC/ICAM2/SDC1/HLA-DOB/PVR/CD8A/CD2/ITGA4/MAG/PTPRF/ITGB2/CLDN11/CD40/HLA-F/CD86/PDCD1LG2/NLGN4X/HLA-DMB/CDH15/NLGN4Y/CTLA4/NRXN1/HLA-C/ITGB7/HLA-DPB1/HLA-DPA1/CD40LG/CNTN1/MPZL1/HLA-DMA/HLA-G/SIGLEC1/CDH3/ICAM3/CD58/ITGAL/HLA-DQB1	39
KEGG	hsa04810	Regulation of actin cytoskeleton	55/1759	218/8135	0.111	0.2611	0.1884	GSN/FGFR1/SCIN/IQGAP2/PIP5K1A/PAK2/PPP1R12A/EZR/ITGB4/FGF21/ACTR2/ARPC5/CYFIP2/PIK3CA/PXN/VAV2/ITGA7/PIP5K1B/FGFR4/ITGA4/PAK3/PIK3CB/INSRR/ITGB2/MYL5/BAIAP2/ITGB3/FGF5/ROCK1/PPP1CA/EGFR/CXCR4/PIP4K2C/PDGFC/ARAF/FN1/WASL/NRAS/RAC1/MAPK1/IQGAP1/ARHGAP35/ITGB7/F2R/FGF17/TMSB4Y/VAV1/PDGFA/RRAS/RAC2/ACTR3/PAK1/PIK3R1/GIT1/ITGAL	55
KEGG	hsa04520	Adherens junction	20/1759	71/8135	0.1167	0.2721	0.1964	FGFR1/CTNNB1/TGFBR2/LEF1/PTPRF/MAP3K7/CTNNA1/AFDN/BAIAP2/NLK/EGFR/WASL/CREBBP/PTPN6/RAC1/MAPK1/PTPN1/IQGAP1/SNAI1/RAC2	20
KEGG	hsa04720	Long-term potentiation	19/1759	67/8135	0.1177	0.2721	0.1964	PRKACB/GRIN2C/PRKCB/ITPR2/RPS6KA1/PPP1CA/ARAF/CREBBP/NRAS/ADCY1/MAPK1/ITPR1/PPP3CC/PPP3CB/CALML3/CALM1/CAMK2B/ADCY8/PRKACA	19
KEGG	hsa04217	Necroptosis	41/1759	159/8135	0.1181	0.2721	0.1964	JAK2/IRF9/MAPK9/FAS/STAT1/TNFSF10/BIRC3/PARP1/TLR3/VDAC3/STAT5A/CASP1/PLA2G4A/TNFRSF10B/GLUD1/STAT4/FTL/PPID/IFNAR1/RBCK1/FADD/STAT6/HSP90AA1/JAK1/JAK3/SQSTM1/IFNGR2/IFNA1/PLA2G4C/TNFRSF1A/SMPD1/IFNAR2/TRAF5/CAMK2B/SLC25A31/TRADD/CHMP7/IFNG/PYCARD/MAPK8/AIFM1	41
KEGG	hsa00514	Other types of O-glycan biosynthesis	14/1759	47/8135	0.1198	0.274	0.1978	GALNT10/B4GALT2/MFNG/ST6GAL1/C1GALT1C1/POFUT1/C1GALT1/GALNT6/B4GALT1/LFNG/GALNT8/POFUT2/PLOD3/POMT2	14
KEGG	hsa05225	Hepatocellular carcinoma	43/1759	168/8135	0.1222	0.2777	0.2004	PLCG2/BRD7/AKT2/BCL2L1/CTNNB1/LRP6/TGFBR2/LEF1/ARID1A/GADD45B/FZD2/PIK3CA/PRKCB/WNT7A/PIK3CB/E2F3/TERT/SMAD2/FZD3/DDB2/SMARCA4/DPF1/TGFB2/WNT5A/CDKN1A/FRAT1/EGFR/ARAF/FZD9/FZD1/TP53/NRAS/HMOX1/MAPK1/MYC/TXNRD2/WNT6/BAK1/SHC1/PIK3R1/PLCG1/WNT1/FZD6	43
KEGG	hsa04066	HIF-1 signaling pathway	29/1759	109/8135	0.1252	0.2813	0.203	PLCG2/CUL2/AKT2/RBX1/PIK3CA/PRKCB/ENO1/PIK3CB/ENO3/PDK1/CDKN1A/EGFR/ENO2/CREBBP/HMOX1/EGLN3/MAPK1/IFNGR2/CDKN1B/IL6/ANGPT2/CAMK2B/EPO/NFKB1/RPS6/ALDOC/IFNG/PIK3R1/PLCG1	29
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	37/1759	143/8135	0.1274	0.2813	0.203	JAK2/FGFR1/AKT2/CTNNB1/MAPK14/LIF/FZD2/PIK3CA/ID2/SOX2/FGFR4/IL6ST/WNT7A/ID4/PIK3CB/SMAD2/FZD3/HOXA1/DUSP9/POU5F1B/WNT5A/KLF4/JAK1/JAK3/FZD9/FZD1/NRAS/MAPK1/LEFTY1/MYC/NANOG/WNT6/INHBA/PIK3R1/ACVR2A/WNT1/FZD6	37
KEGG	hsa04971	Gastric acid secretion	21/1759	76/8135	0.1287	0.2813	0.203	PRKACB/GNAI3/EZR/ADCY6/ADCY7/PRKCB/KCNJ2/ITPR2/ATP4A/KCNK2/GNAI2/ADCY1/ITPR1/ATP1B2/SSTR2/CALML3/CALM1/CAMK2B/ATP1B3/ADCY8/PRKACA	21
KEGG	hsa03450	Non-homologous end-joining	5/1759	13/8135	0.1292	0.2813	0.203	MRE11/XRCC4/FEN1/DNTT/LIG4	5
KEGG	hsa04150	mTOR signaling pathway	40/1759	156/8135	0.1295	0.2813	0.203	AKT2/ATP6V1D/CAB39/LRP6/ATP6V1H/SLC3A2/WDR59/FZD2/PIK3CA/PRKCB/GRB10/ATP6V1E1/WNT7A/PIK3CB/FZD3/RPS6KA1/STK11/NPRL3/ATP6V1A/DDIT4/LAMTOR3/WNT5A/DEPDC5/FZD9/FZD1/SGK1/NRAS/MAPK1/WNT6/RHEB/TNFRSF1A/ATP6V1B1/SEC13/RRAGC/RPS6/PIK3R1/PRKAA2/ULK1/WNT1/FZD6	40
KEGG	hsa05418	Fluid shear stress and atherosclerosis	36/1759	139/8135	0.1298	0.2813	0.203	MAPK9/AKT2/MAP2K7/CTNNB1/DUSP1/MAPK14/PRKCZ/JUN/IL1R1/SDC1/PIK3CA/SUMO3/GPC1/PIK3CB/MAP2K4/MAP3K7/FOS/ITGB3/HSP90AA1/SQSTM1/TP53/RAC1/HMOX1/THBD/TNFRSF1A/PDGFA/CALML3/CALM1/TXN2/RAC2/NFKB1/IFNG/MAPK8/PIK3R1/PRKAA2/ACVR2A	36
KEGG	hsa05218	Melanoma	20/1759	72/8135	0.1303	0.2813	0.203	FGFR1/AKT2/FGF21/GADD45B/PIK3CA/PIK3CB/E2F3/DDB2/CDKN1A/FGF5/EGFR/PDGFC/ARAF/TP53/NRAS/MAPK1/FGF17/BAK1/PDGFA/PIK3R1	20
KEGG	hsa04070	Phosphatidylinositol signaling system	26/1759	97/8135	0.1317	0.2813	0.203	PLCG2/MTMR6/PI4K2A/PIP5K1A/MTMR4/CDS2/PIK3CA/PRKCB/PIP5K1B/MTMR14/PIK3CB/IMPA1/ITPR2/MTM1/MTMR3/DGKQ/PIP4K2C/PPIP5K2/ITPR1/CALML3/CALM1/PLCD1/IP6K2/ITPKA/PIK3R1/PLCG1	26
KEGG	hsa04713	Circadian entrainment	26/1759	97/8135	0.1317	0.2813	0.203	PRKACB/GNAI3/GRIN2C/CACNA1I/ADCY6/GNG3/ADCY7/PRKCB/GUCY1B1/RYR1/PER3/FOS/GNAI2/ADCY1/MAPK1/RPS6KA5/ITPR1/GNB3/PRKG1/ADCYAP1R1/CACNA1H/CALML3/CALM1/CAMK2B/ADCY8/PRKACA	26
KEGG	hsa04360	Axon guidance	46/1759	182/8135	0.1322	0.2813	0.203	PLCG2/GNAI3/PAK2/NCK1/EFNB1/PRKCZ/RASA1/SEMA6D/PIK3CA/SEMA4D/PAK3/PIK3CB/SEMA4A/RND1/FZD3/MYL5/NFATC4/EFNB2/SLIT1/WNT5A/ROCK1/SEMA3C/SHH/PLXNB1/SEMA6A/CXCR4/SEMA3B/NTN3/GNAI2/NRAS/RAC1/MAPK1/PPP3CC/CDK5/EFNA5/PPP3CB/RRAS/CAMK2B/EFNA4/RAC2/PAK1/SEMA4C/UNC5C/PIK3R1/SEMA7A/PLCG1	46
KEGG	hsa04136	Autophagy - other	10/1759	32/8135	0.1346	0.284	0.205	GABARAPL1/ATG4A/PPP2CB/ATG2B/ATG5/ATG13/WIPI1/PPP2CA/ATG4B/ATG16L1	10
KEGG	hsa04340	Hedgehog signaling pathway	16/1759	56/8135	0.1356	0.284	0.205	CSNK1G3/PRKACB/IQCE/FBXW11/GRK2/CDON/CSNK1G2/SHH/CSNK1D/IHH/SPOP/GRK3/GLI1/MEGF8/PTCH2/PRKACA	16
KEGG	hsa04211	Longevity regulating pathway	24/1759	89/8135	0.1361	0.284	0.205	PRKACB/AKT2/ADCY6/PIK3CA/ADCY7/EHMT1/PIK3CB/STK11/ATG5/ATG13/CREB3/TP53/NRAS/ADCY1/ADIPOR1/RHEB/IRS2/ADCY8/NFKB1/PIK3R1/PRKAA2/PRKACA/ULK1/ATF6B	24
KEGG	hsa04728	Dopaminergic synapse	34/1759	132/8135	0.1456	0.3009	0.2172	MAPK9/PRKACB/AKT2/GNAI3/MAPK14/GNG3/PPP2CB/PRKCB/CACNA1B/TH/ITPR2/FOS/PPP1CA/PPP2R5C/CREB3/GNAI2/DRD3/SLC6A3/ITPR1/PPP2R1A/PPP3CC/GNB3/PPP2CA/CALY/PPP2R1B/PPP3CB/CALML3/CALM1/CAMK2B/CLOCK/MAPK8/PRKACA/GSK3A/ATF6B	34
KEGG	hsa04924	Renin secretion	19/1759	69/8135	0.1468	0.3009	0.2172	PRKACB/GNAI3/PDE1B/ADCY6/KCNJ2/GUCY1B1/AGT/ITPR2/EDN2/CACNA1S/GNAI2/ITPR1/ADORA1/PPP3CC/ADCYAP1R1/PPP3CB/CALML3/CALM1/PRKACA	19
KEGG	hsa05031	Amphetamine addiction	19/1759	69/8135	0.1468	0.3009	0.2172	PRKACB/GRIN2C/FOSB/JUN/PRKCB/TH/FOS/PPP1CA/CREB3/SLC6A3/PPP3CC/PPP3CB/STX1A/CALML3/CALM1/CAMK2B/PRKACA/HDAC1/ATF6B	19
KEGG	hsa04141	Protein processing in endoplasmic reticulum	43/1759	171/8135	0.15	0.3054	0.2204	DNAJC10/MAPK9/MAP2K7/UBE2J1/RBX1/SSR1/RRBP1/TRAM1/HSPA4L/UBE2G2/RNF5/SEC63/UBE2G1/STUB1/EIF2AK1/PLAA/HSP90AA1/EDEM1/ATXN3/PPP1R15A/SEC24A/UFD1/SEC23A/EDEM3/HERPUD1/DNAJC1/SSR4/PREB/ERO1A/BAK1/NPLOC4/PDIA4/HSPA1L/ERN1/UBE2D4/SEC24B/SEC13/DNAJB12/MAPK8/SEC23B/EDEM2/RAD23B/ATF6B	43
KEGG	hsa00920	Sulfur metabolism	4/1759	10/8135	0.151	0.3057	0.2206	PAPSS1/PAPSS2/SQOR/BPNT1	4
KEGG	hsa04910	Insulin signaling pathway	35/1759	137/8135	0.1537	0.3093	0.2232	MAPK9/PRKACB/AKT2/SOCS3/RAPGEF1/PRKCZ/PIK3CA/PTPRF/PIK3CB/FLOT2/PPP1CA/ARAF/GCK/EXOC7/NRAS/G6PC3/MAPK1/PTPN1/FASN/RHEB/GYS1/PHKG1/PKLR/CALML3/CALM1/IRS2/SHC1/ACACB/RPS6/MAPK8/PIK3R1/PRKAA2/PRKACA/PHKB/SOCS2	35
KEGG	hsa05030	Cocaine addiction	14/1759	49/8135	0.1558	0.3099	0.2237	PRKACB/GNAI3/GRIN2C/FOSB/JUN/TH/CREB3/GNAI2/SLC6A3/CDK5/BDNF/NFKB1/PRKACA/ATF6B	14
KEGG	hsa03410	Base excision repair	10/1759	33/8135	0.1577	0.3099	0.2237	PCNA/POLD3/POLB/PARP1/PARP2/APEX2/PARP4/FEN1/MBD4/POLE	10
KEGG	hsa04130	SNARE interactions in vesicular transport	10/1759	33/8135	0.1577	0.3099	0.2237	STX18/SEC22B/BET1L/VAMP8/STX7/VAMP5/BET1/STX1A/SNAP29/SNAP23	10
KEGG	hsa05219	Bladder cancer	12/1759	41/8135	0.1577	0.3099	0.2237	E2F3/CDKN1A/UPK3A/EGFR/ARAF/TP53/NRAS/MAPK1/RPS6KA5/MYC/MMP1/DAPK2	12
KEGG	hsa04120	Ubiquitin mediated proteolysis	36/1759	142/8135	0.1618	0.3141	0.2267	CUL2/SOCS3/UBE2A/UBE2J1/FBXW11/BIRC3/UBE2L6/RBX1/TRAF6/DET1/UBE2G2/HERC1/AIRE/UBA3/UBC/UBE2G1/DDB2/STUB1/UBE2H/ERCC8/UBE2L3/CDC20/CDC16/HERC4/UBE2Q1/UBE2I/UBE2Z/FANCL/SAE1/TRIM37/SIAH1/CDC23/PIAS1/UBE2D4/RNF7/CBLC	36
KEGG	hsa04936	Alcoholic liver disease	36/1759	142/8135	0.1618	0.3141	0.2267	MAPK9/AKT2/FAS/MAP2K7/TAB2/CTNNB1/MAPK14/TRAF6/LEF1/MAP2K4/IL17RC/MAP3K7/FADD/CASP3/TBK1/TRAF3/ADIPOR1/CYP2E1/IFNA1/FASN/NOX4/TNFRSF1A/IL6/C3AR1/CPT1A/ADH6/TRA2B/ACACB/TRADD/FABP1/NFKB1/TRA2A/MAPK8/PRKAA2/LY96/CD14	36
KEGG	hsa04622	RIG-I-like receptor signaling pathway	19/1759	70/8135	0.1628	0.3143	0.2269	RNF125/CXCL10/MAPK9/IFIH1/MAPK14/TRAF6/TRIM25/MAP3K7/FADD/TBK1/ATG5/DDX58/TBKBP1/TRAF3/IFNA1/TRADD/NFKB1/IRF7/MAPK8	19
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	21/1759	79/8135	0.173	0.3321	0.2396	JAK2/PLCG2/AKT2/BCL2L1/PIK3CA/PRKCB/PIK3CB/JAK1/EGFR/GAS6/PDGFC/ARAF/NRAS/MAPK1/NF1/IL6/PDGFA/SHC1/RPS6/PIK3R1/PLCG1	21
KEGG	hsa05110	Vibrio cholerae infection	14/1759	50/8135	0.1757	0.3353	0.242	PLCG2/PRKACB/ATP6V1D/ATP6V1H/KDELR3/ATP6V0E1/ATP6V1E1/ATP6V1A/ATP6AP1/ERO1A/ATP6V1B1/PDIA4/PRKACA/PLCG1	14
KEGG	hsa04145	Phagosome	38/1759	152/8135	0.1776	0.337	0.2432	STX18/ATP6V1D/TAP1/FCGR2B/ATP6V1H/STX12/ATP6V0E1/SEC22B/DYNC1I2/HLA-DOB/ATP6V1E1/ITGB2/STX7/ATP6V1A/HLA-F/ITGB3/TUBA8/TUBB/HLA-DMB/RAC1/TUBA1A/TUBB2A/HLA-C/ATP6AP1/COLEC12/NCF4/HLA-DPB1/COLEC11/HLA-DPA1/CORO1A/ATP6V1B1/HLA-DMA/DYNC1LI1/HLA-G/LAMP1/THBS2/CD14/HLA-DQB1	38
KEGG	hsa00900	Terpenoid backbone biosynthesis	7/1759	22/8135	0.1802	0.34	0.2453	MVK/GGPS1/ICMT/HMGCR/MVD/ZMPSTE24/DHDDS	7
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1759	26/8135	0.1823	0.3402	0.2455	PIGN/PIGV/PIGC/PIGB/PIGF/PIGK/PIGQ/GPAA1	8
KEGG	hsa04950	Maturity onset diabetes of the young	8/1759	26/8135	0.1823	0.3402	0.2455	HES1/HHEX/HNF1A/HNF4A/SLC2A2/GCK/PKLR/PDX1	8
KEGG	hsa04390	Hippo signaling pathway	39/1759	157/8135	0.1854	0.344	0.2482	DLG5/CTNNB1/FBXW11/BIRC3/TGFBR2/LEF1/MPP5/PRKCZ/LLGL2/CCND3/FZD2/ID2/PPP2CB/SOX2/YWHAZ/WNT7A/SMAD2/FZD3/ITGB2/CTNNA1/TGFB2/WNT5A/YWHAH/GDF5/PPP1CA/CSNK1D/FZD9/FZD1/BMP8A/MYC/PPP2R1A/WNT6/FRMD1/PPP2CA/PPP2R1B/AREG/WWTR1/WNT1/FZD6	39
KEGG	hsa04913	Ovarian steroidogenesis	14/1759	51/8135	0.1967	0.3627	0.2617	PRKACB/HSD17B1/ADCY6/LDLR/ADCY7/PLA2G4A/PTGS2/CYP17A1/ADCY1/PLA2G4C/CYP1B1/FSHB/ADCY8/PRKACA	14
KEGG	hsa04727	GABAergic synapse	23/1759	89/8135	0.1976	0.3627	0.2617	GABARAPL1/PRKACB/GNAI3/HAP1/ADCY6/GNG3/ADCY7/PRKCB/CACNA1B/SLC38A3/NSF/CACNA1S/GAD2/SLC6A11/GNAI2/ADCY1/GABRD/GNB3/PLCL1/ADCY8/GABRR1/GABRR2/PRKACA	23
KEGG	hsa04972	Pancreatic secretion	26/1759	102/8135	0.2002	0.3654	0.2637	RAB8A/CD38/ADCY6/ADCY7/PRKCB/PLA2G2D/RAB3D/CEL/RAB11A/ITPR2/PRSS2/CELA3A/PLA2G2E/RAC1/ADCY1/ITPR1/ATP1B2/ATP2B4/CPA1/ATP1B3/CELA2B/ADCY8/PLA2G12A/ATP2A3/CTRB2/SCT	26
KEGG	hsa04929	GnRH secretion	17/1759	64/8135	0.2057	0.3735	0.2695	AKT2/CACNA1I/KCNN4/PIK3CA/PRKCB/PIK3CB/ITPR2/KCNN2/KCNN3/CACNA1S/GNA11/NRAS/MAPK1/ITPR1/CACNA1H/GNRH2/PIK3R1	17
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1759	15/8135	0.2083	0.3762	0.2715	ST8SIA1/B3GALNT1/NAGA/HEXB/FUT2	5
KEGG	hsa04710	Circadian rhythm	9/1759	31/8135	0.2114	0.3775	0.2724	BHLHE41/FBXW11/RBX1/BHLHE40/PER3/NPAS2/CSNK1D/CLOCK/PRKAA2	9
KEGG	hsa04152	AMPK signaling pathway	30/1759	120/8135	0.2115	0.3775	0.2724	AKT2/CAB39/RAB8A/EEF2/CCNA2/PIK3CA/PPP2CB/PIK3CB/MAP3K7/TBC1D1/STK11/HNF4A/PPP2R5C/HMGCR/CREB3/G6PC3/ADIPOR1/FASN/PPP2R1A/RHEB/PPP2CA/GYS1/PPP2R1B/IRS2/CPT1A/ACACB/PIK3R1/PRKAA2/ULK1/PFKFB4	30
KEGG	hsa04966	Collecting duct acid secretion	8/1759	27/8135	0.213	0.3775	0.2724	ATP6V1D/CLCNKB/ATP6V0E1/ATP6V1E1/ATP4A/ATP6V1A/ATP6V1B1/SLC12A7	8
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	7/1759	23/8135	0.2136	0.3775	0.2724	SLC25A10/GLUD1/SLC38A3/ATP1B2/MDH1/ATP1B3/CA4	7
KEGG	hsa00562	Inositol phosphate metabolism	19/1759	73/8135	0.2159	0.3795	0.2739	PLCG2/FIG4/MTMR6/PI4K2A/PIP5K1A/MINPP1/MTMR4/PIK3CA/PIP5K1B/MTMR14/PIK3CB/IMPA1/MTM1/MTMR3/PIP4K2C/TPI1/PLCD1/ITPKA/PLCG1	19
KEGG	hsa04915	Estrogen signaling pathway	34/1759	138/8135	0.2202	0.3851	0.2779	PRKACB/AKT2/GNAI3/FKBP5/KRT33A/ADCY6/JUN/PIK3CA/ADCY7/PIK3CB/ITPR2/FOS/KRT32/HSP90AA1/NCOA1/PRKCD/EGFR/KRT13/CREB3/GNAI2/NRAS/ADCY1/MAPK1/ITPR1/EBAG9/CALML3/CALM1/HSPA1L/SHC1/ADCY8/PIK3R1/PRKACA/OPRM1/ATF6B	34
KEGG	hsa05012	Parkinson disease	63/1759	266/8135	0.2235	0.3888	0.2806	MAPK9/PRKACB/BCL2L1/GNAI3/MFN2/UBE2J1/DUSP1/NDUFA9/UBE2L6/ATP5PB/PSMC2/UBE2G2/NDUFS3/NDUFS1/VDAC3/SLC39A6/TH/UBC/UBE2G1/ITPR2/SNCA/CASP3/SDHA/PSMD3/TUBA8/UBE2L3/MFN1/TRAP1/TUBB/PSMD4/PSMA5/TP53/GNAI2/NDUFS7/PSMB4/TUBA1A/TUBB2A/SLC6A3/ITPR1/PSMA4/UQCRC1/MAPT/NDUFA8/SLC39A8/PPIF/PSMB7/ATP5PD/CALML3/PSMA2/CALM1/CAMK2B/COX6A2/PSMB5/ERN1/SLC25A31/TXN2/SLC39A7/KLC1/MAPK8/PRKACA/PSMD8/PLCG1/ATP5F1A	63
KEGG	hsa03013	Nucleocytoplasmic transport	27/1759	108/8135	0.2265	0.392	0.2829	TPR/EEF1A1/IPO8/NUP37/UPF1/XPO7/SUMO3/XPO1/NXT2/POM121/NUP85/NUP107/SNUPN/NUP133/XPO4/IPO9/UBE2I/NXF3/UPF3B/RANBP17/NMD3/NDC1/SEC13/ACIN1/THOC2/NUP93/TNPO2	27
KEGG	hsa04962	Vasopressin-regulated water reabsorption	12/1759	44/8135	0.228	0.3926	0.2833	PRKACB/ADCY6/DYNC1I2/AQP2/RAB11A/NSF/AVP/CREB3/AVPR2/ARHGDIB/DYNC1LI1/PRKACA	12
KEGG	hsa05032	Morphine addiction	23/1759	91/8135	0.2314	0.3963	0.286	PRKACB/GNAI3/PDE1B/ADCY6/GNG3/ADCY7/PRKCB/CACNA1B/GRK2/PDE4B/GNAI2/ADCY1/GRK3/GABRD/ADORA1/GNB3/ADCY8/GABRR1/GABRR2/GRK6/PRKACA/OPRM1/PDE8A	23
KEGG	hsa00350	Tyrosine metabolism	10/1759	36/8135	0.2371	0.4028	0.2907	GOT2/PNMT/TH/FAH/HPD/ALDH3A1/HGD/MIF/TYRP1/ADH6	10
KEGG	hsa04072	Phospholipase D signaling pathway	36/1759	148/8135	0.2376	0.4028	0.2907	PLCG2/AKT2/PIP5K1A/ADCY6/PIK3CA/ADCY7/SYK/PLA2G4A/PIP5K1B/AGT/PIK3CB/CYTH3/CYTH1/GRM4/PIK3R5/AGPAT3/DGKQ/EGFR/PDGFC/PLPP3/AVP/NRAS/ADCY1/MAPK1/PLA2G4C/RHEB/F2R/AVPR2/PDGFA/RRAS/LPAR6/SHC1/ADCY8/PIK3R1/PLD1/PLCG1	36
KEGG	hsa05230	Central carbon metabolism in cancer	18/1759	70/8135	0.2409	0.4053	0.2925	FGFR1/AKT2/PGAM1/PIK3CA/PIK3CB/IDH2/PDK1/NTRK1/EGFR/SLC2A2/GCK/TP53/NRAS/MAPK1/MYC/SLC1A5/PIK3R1/TIGAR	18
KEGG	hsa04215	Apoptosis - multiple species	9/1759	32/8135	0.2415	0.4053	0.2925	MAPK9/BCL2L1/BIRC3/FADD/CASP3/DIABLO/TNFRSF1A/BAK1/MAPK8	9
KEGG	hsa00100	Steroid biosynthesis	6/1759	20/8135	0.2517	0.4183	0.3019	CEL/MSMO1/CYP24A1/SC5D/LSS/LBR	6
KEGG	hsa00670	One carbon pool by folate	6/1759	20/8135	0.2517	0.4183	0.3019	TYMS/FTCD/ATIC/SHMT1/MTHFR/ALDH1L1	6
KEGG	hsa02010	ABC transporters	12/1759	45/8135	0.2539	0.4198	0.3029	TAP1/ABCC4/ABCG1/ABCC6/ABCA2/ABCC10/ABCG4/ABCC8/ABCD2/ABCB9/ABCB1/ABCA8	12
KEGG	hsa01230	Biosynthesis of amino acids	19/1759	75/8135	0.2551	0.4198	0.3029	IDH3B/MAT2B/GOT2/MAT2A/PGAM1/BCAT2/ASL/ENO1/TKT/SDS/IDH2/ENO3/ENO2/PRPS2/SHMT1/TPI1/PKLR/TALDO1/ALDOC	19
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	36/1759	150/8135	0.266	0.4317	0.3115	PRKACB/AKT2/GNAI3/MAPK14/ADCY6/ADCY7/PPP2CB/AGT/CACNG2/PIK3R5/TPM3/MYL3/PPP1CA/CACNG5/CACNG1/CACNA1S/PPP2R5C/CREB3/GNAI2/ADCY1/MAPK1/RPS6KA5/PPP2R1A/ATP1B2/PPP2CA/PPP2R1B/AGTR2/ATP2B4/CALML3/CALM1/CAMK2B/ATP1B3/ADCY8/ATP2A3/PRKACA/ATF6B	36
KEGG	hsa00230	Purine metabolism	31/1759	128/8135	0.2666	0.4317	0.3115	DCK/CANT1/NME6/ENTPD1/PDE1B/ADCY6/RRM2/PAPSS1/PAPSS2/ENTPD2/ADCY7/GUCY1B1/AMPD1/ADA2/PDE6D/PDE4B/DGUOK/AMPD3/GUCY2D/PRPS2/GMPR2/ATIC/ADCY1/ENPP4/PRUNE1/ADA/GMPR/ADCY8/RRM1/GMPS/PDE8A	31
KEGG	hsa05168	Herpes simplex virus 1 infection	113/1759	495/8135	0.267	0.4317	0.3115	JAK2/IRF9/IFIH1/AKT2/SOCS3/FAS/BCL2L1/TAP1/TAB2/ZNF430/STAT1/ZNF43/BIRC3/CCL5/TRAF6/ZNF14/ZNF557/ZNF141/ZNF253/ZNF45/ZNF544/OAS2/TLR3/ZNF764/PIK3CA/HLA-DOB/SYK/ZNF257/ZNF160/ZNF419/ZNF529/ZNF780B/PIK3CB/ZNF107/ZNF112/MAP3K7/ZNF184/IFNAR1/ZNF606/ZNF3/ZNF180/FADD/CASP3/EIF2B2/ZNF426/EIF2AK1/HLA-F/ITGB3/TAPBP/TBK1/ZNF85/ZNF324/ZNF200/PPP1CA/JAK1/DDX58/ZNF33B/ZNF331/HLA-DMB/ZNF471/ZNF814/ZNF813/ZNF267/ZNF562/TRAF3/ZNF195/NXF3/TP53/SRSF5/ZNF304/ZNF721/IFNGR2/IFNA1/HLA-C/RNASEL/ZNF468/ZNF350/HLA-DPB1/RHEB/ZNF343/HLA-DPA1/TNFRSF1A/OAS1/IFNAR2/BAK1/ZNF415/IL6/ZNF214/ZNF682/B2M/ZNF667/TRAF5/ZNF302/ZNF211/HLA-DMA/ZNF571/ZNF675/HLA-G/TRADD/ZNF587/SRSF7/ZFP69B/NFKB1/ZNF671/ZNF354A/IRF7/IFNG/PIK3R1/ZNF205/ZNF549/ZNF324B/CD74/HLA-DQB1	113
KEGG	hsa04970	Salivary secretion	23/1759	93/8135	0.2675	0.4317	0.3115	PRKACB/CD38/ADCY6/KCNN4/ADCY7/PRKCB/GUCY1B1/BEST2/ITPR2/ADCY1/ITPR1/CAMP/ATP1B2/PRKG1/ATP2B4/CST3/TRPV6/CALML3/CALM1/ATP1B3/STATH/ADCY8/PRKACA	23
KEGG	hsa01200	Carbon metabolism	28/1759	115/8135	0.2696	0.4329	0.3124	IDH3B/GOT2/OGDHL/PGAM1/ENO1/ADPGK/TKT/SDS/GLUD1/ME1/IDH2/H6PD/ENO3/GPI/SDHA/ENO2/PRPS2/GCK/GLDC/SHMT1/TPI1/HIBCH/MDH1/PKLR/HAO2/TALDO1/ALDOC/DLD	28
KEGG	hsa05146	Amoebiasis	25/1759	102/8135	0.2722	0.4351	0.314	PRKACB/IL1R1/PIK3CA/PRKCB/PIK3CB/CSF2/ITGB2/CASP3/TGFB2/C8G/CTSG/LAMC3/IL10/FN1/GNA11/SERPINB6/ADCY1/MUC2/IL6/NFKB1/IFNG/PIK3R1/PRKACA/COL4A3/CD14	25
KEGG	hsa04020	Calcium signaling pathway	56/1759	240/8135	0.2798	0.4451	0.3212	PLCG2/PRKACB/FGFR1/ASPH/CD38/GRIN2C/PTGER1/PDE1B/CACNA1I/FGF21/VDAC3/ADCY7/PRKCB/CACNA1B/TACR2/FGFR4/RYR1/EDNRB/NTRK2/ITPR2/HTR6/P2RX6/NTRK1/FGF5/GDNF/EGFR/CXCR4/PDGFC/CACNA1S/GNA11/ADCY1/ITPR1/NTSR1/PPP3CC/P2RX2/F2R/FGF17/PHKG1/CACNA1H/PPP3CB/CACNA1E/ATP2B4/PDGFA/PPIF/CALML3/CALM1/CAMK2B/SLC25A31/PLCD1/ADCY8/ATP2A3/ITPKA/PRKACA/PHKB/PLCG1/ADORA2B	56
KEGG	hsa05010	Alzheimer disease	88/1759	384/8135	0.2827	0.4475	0.323	MAPK9/AKT2/FAS/MAP2K7/CTNNB1/ADAM10/NDUFA9/ATP5PB/LRP1/IDE/LRP6/GRIN2C/PSMC2/NDUFS3/NDUFS1/FZD2/PIK3CA/VDAC3/SLC39A6/ATG2B/WNT7A/APP/PIK3CB/ITPR2/PPID/FZD3/FADD/SNCA/CASP3/PTGS2/SDHA/PSMD3/WNT5A/TUBA8/FRAT1/TUBB/ARAF/ATG13/FZD9/PSMD4/CACNA1S/PSMA5/FZD1/NRAS/NDUFS7/WIPI1/MAPK1/PSMB4/TUBA1A/PSEN1/TUBB2A/NOX4/ITPR1/PSMA4/UQCRC1/PPP3CC/MAPT/WNT6/CSF1/TNFRSF1A/NDUFA8/CDK5/SLC39A8/RTN4/PPP3CB/IL6/PPIF/PSMB7/ATP5PD/CALML3/PSMA2/CALM1/COX6A2/PSMB5/IRS2/ERN1/SLC25A31/SLC39A7/NFKB1/KLC1/ATP2A3/MAPK8/PIK3R1/PSMD8/ATP5F1A/ULK1/WNT1/FZD6	88
KEGG	hsa05414	Dilated cardiomyopathy	23/1759	96/8135	0.3253	0.5118	0.3693	PRKACB/ITGB4/ADCY6/ADCY7/ITGA7/ITGA4/SGCA/AGT/CACNG2/MYBPC3/TGFB2/TPM3/ITGB3/EMD/MYL3/CACNG5/CACNG1/CACNA1S/ADCY1/ITGB7/ADCY8/ATP2A3/PRKACA	23
KEGG	hsa00600	Sphingolipid metabolism	13/1759	52/8135	0.3264	0.5118	0.3693	SGPP1/CERK/CERS6/SPTLC3/GAL3ST1/SGPL1/SMPD2/PLPP3/SPTLC2/SMPD1/CERS4/HEXB/NEU2	13
KEGG	hsa05134	Legionellosis	14/1759	57/8135	0.3428	0.535	0.3861	EEF1A1/SEC22B/HSF1/CASP1/NFKB2/ITGB2/CASP3/IL18/CR1/IL6/HSPA1L/NFKB1/PYCARD/CD14	14
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1759	14/8135	0.3585	0.5569	0.4019	FUT8/B3GNT2/B4GALT2/B4GALT1	4
KEGG	hsa04976	Bile secretion	21/1759	89/8135	0.3645	0.5637	0.4068	PRKACB/ABCC4/ADCY6/LDLR/ADCY7/UGT2B17/KCNN2/AQP8/HMGCR/ADCY1/NR0B2/ATP1B2/SLC22A7/SLC22A1/NR1H4/ATP1B3/ADCY8/UGT2B4/PRKACA/ABCB1/SCT	21
KEGG	hsa00010	Glycolysis / Gluconeogenesis	16/1759	67/8135	0.3719	0.5698	0.4113	BPGM/MINPP1/PGAM1/ENO1/ADPGK/ENO3/GPI/ALDH3A1/ENO2/GCK/G6PC3/TPI1/PKLR/ADH6/ALDOC/DLD	16
KEGG	hsa05221	Acute myeloid leukemia	16/1759	67/8135	0.3719	0.5698	0.4113	AKT2/LEF1/CCNA2/PIK3CA/STAT5A/PIK3CB/CSF2/CSF1R/PIM2/ARAF/NRAS/MAPK1/MYC/NFKB1/PIK3R1/CD14	16
KEGG	hsa04614	Renin-angiotensin system	6/1759	23/8135	0.3778	0.5762	0.4158	PREP/AGT/CTSG/ATP6AP2/CMA1/AGTR2	6
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1759	77/8135	0.3971	0.6029	0.4351	CTNNB1/DSC2/LEF1/ITGB4/ITGA7/ITGA4/SGCA/CACNG2/CTNNA1/ITGB3/EMD/ACTN3/CACNG5/CACNG1/CACNA1S/ITGB7/DSP/ATP2A3	18
KEGG	hsa01250	Biosynthesis of nucleotide sugars	9/1759	37/8135	0.4067	0.6119	0.4416	UXS1/FPGT/CMAS/NAGK/TGDS/GPI/GALK2/GCK/GFPT1	9
KEGG	hsa05143	African trypanosomiasis	9/1759	37/8135	0.4067	0.6119	0.4416	APOA1/FAS/PRKCB/IDO1/IL10/IL18/IL6/HBB/IFNG	9
KEGG	hsa04932	Non-alcoholic fatty liver disease	35/1759	155/8135	0.4164	0.6236	0.4501	MAPK9/AKT2/SOCS3/FAS/NDUFA9/MAPK14/JUN/NDUFS3/NDUFS1/PIK3CA/MLXIP/PIK3CB/MAP3K11/FOS/CASP3/SDHA/NDUFS7/RAC1/ADIPOR1/CYP2E1/UQCRC1/NR1H3/TNFRSF1A/NDUFA8/IL6/PKLR/COX6A2/MLXIPL/IRS2/ERN1/NFKB1/MAPK8/PIK3R1/PRKAA2/GSK3A	35
KEGG	hsa04977	Vitamin digestion and absorption	6/1759	24/8135	0.4207	0.6273	0.4527	APOA1/SLC19A1/LMBRD1/MMACHC/APOA4/SLC19A2	6
KEGG	hsa04510	Focal adhesion	45/1759	201/8135	0.4226	0.6273	0.4528	MAPK9/AKT2/CTNNB1/PIP5K1A/PAK2/BIRC3/PPP1R12A/RAPGEF1/COL6A1/ITGB4/JUN/CCND3/PIK3CA/PXN/PRKCB/VAV2/ITGA7/PIP5K1B/ITGA4/PAK3/PIK3CB/RASGRF1/TNXB/MYL5/FLNB/ITGB3/ROCK1/PPP1CA/LAMC3/EGFR/PDGFC/FN1/RAC1/MAPK1/ARHGAP35/ITGB7/VAV1/PDGFA/SHC1/RAC2/THBS2/PAK1/MAPK8/PIK3R1/COL4A3	45
KEGG	hsa03015	mRNA surveillance pathway	22/1759	97/8135	0.4392	0.6491	0.4684	FUS/CPSF1/UPF1/GSPT2/PPP2CB/NXT2/RNGTT/PPP1CA/PAPOLA/CSTF1/DAZAP1/PPP2R5C/NXF3/CLP1/PPP2R1A/PABPC3/NUDT21/UPF3B/PPP2CA/PAPOLG/PPP2R1B/ACIN1	22
KEGG	hsa00591	Linoleic acid metabolism	7/1759	29/8135	0.4419	0.6502	0.4693	PLA2G6/PLA2G4A/PLA2G2D/PLA2G2E/CYP2E1/PLA2G4C/PLA2G12A	7
KEGG	hsa03018	RNA degradation	18/1759	79/8135	0.4443	0.6509	0.4698	DCPS/PARN/ENO1/TTC37/CNOT9/DCP2/ENO3/EDC3/BTG2/LSM1/EXOSC2/ENO2/CNOT2/PABPC3/TOB2/CNOT7/MTREX/CNOT1	18
KEGG	hsa04918	Thyroid hormone synthesis	17/1759	75/8135	0.4579	0.6674	0.4817	PRKACB/ADCY6/ADCY7/PRKCB/ITPR2/CREB3/ADCY1/ITPR1/ATP1B2/ASGR1/SERPINA7/PDIA4/ATP1B3/GPX3/ADCY8/PRKACA/ATF6B	17
KEGG	hsa03020	RNA polymerase	8/1759	34/8135	0.4596	0.6674	0.4817	POLR2F/POLR1B/CRCP/POLR3B/POLR3K/POLR3G/POLR2E/POLR1D	8
KEGG	hsa00592	alpha-Linolenic acid metabolism	6/1759	25/8135	0.4632	0.6697	0.4833	PLA2G6/PLA2G4A/PLA2G2D/PLA2G2E/PLA2G4C/PLA2G12A	6
KEGG	hsa00360	Phenylalanine metabolism	4/1759	16/8135	0.4666	0.6718	0.4848	GOT2/HPD/ALDH3A1/MIF	4
KEGG	hsa00030	Pentose phosphate pathway	7/1759	30/8135	0.4807	0.689	0.4973	DERA/TKT/H6PD/GPI/PRPS2/TALDO1/ALDOC	7
KEGG	hsa00790	Folate biosynthesis	6/1759	26/8135	0.5048	0.7181	0.5182	GGH/GCH1/TH/ALPI/AKR1B10/MOCS2	6
KEGG	hsa04724	Glutamatergic synapse	25/1759	114/8135	0.5052	0.7181	0.5182	PRKACB/GNAI3/GRIN2C/ADCY6/GNG3/ADCY7/PRKCB/PLA2G4A/GRK2/ITPR2/GRM4/SLC38A3/GNAI2/ADCY1/MAPK1/ITPR1/GRK3/SLC1A1/PLA2G4C/PPP3CC/GNB3/PPP3CB/ADCY8/PRKACA/PLD1	25
KEGG	hsa00260	Glycine, serine and threonine metabolism	9/1759	40/8135	0.5082	0.7193	0.5191	ALAS1/BPGM/PGAM1/SARDH/SDS/SRR/GLDC/SHMT1/DLD	9
KEGG	hsa00450	Selenocompound metabolism	4/1759	17/8135	0.5182	0.7232	0.522	PAPSS1/PAPSS2/SEPHS1/TXNRD2	4
KEGG	hsa00910	Nitrogen metabolism	4/1759	17/8135	0.5182	0.7232	0.522	CA12/GLUD1/CA5A/CA4	4
KEGG	hsa03022	Basal transcription factors	10/1759	45/8135	0.5196	0.7232	0.522	GTF2E1/TAF15/CDK7/GTF2I/TAF1/GTF2E2/GTF2H1/GTF2IRD1/GTF2B/TAF6L	10
KEGG	hsa04726	Serotonergic synapse	25/1759	115/8135	0.5249	0.7232	0.522	PRKACB/GNAI3/DUSP1/GNG3/PRKCB/CACNA1B/PLA2G4A/ALOX12B/APP/ITPR2/HTR6/CASP3/PTGS2/KCNN2/ARAF/CACNA1S/CYP2D6/GNAI2/NRAS/MAPK1/ITPR1/PLA2G4C/GNB3/KCND2/PRKACA	25
KEGG	hsa05020	Prion disease	59/1759	273/8135	0.5263	0.7232	0.522	MAPK9/PRKACB/EGR1/NDUFA9/CCL5/ATP5PB/MAPK14/GRIN2C/PSMC2/NDUFS3/NDUFS1/PIK3CA/VDAC3/CACNA1B/RYR1/PIK3CB/C7/ITPR2/CASP3/SDHA/PSMD3/C8G/TUBA8/PRKCD/TUBB/PSMD4/CACNA1S/PSMA5/CREB3/NDUFS7/RAC1/MAPK1/PSMB4/TUBA1A/TUBB2A/ITPR1/PSMA4/UQCRC1/PPP3CC/NCF4/NDUFA8/PPP3CB/IL6/PPIF/PSMB7/ATP5PD/PSMA2/HSPA1L/COX6A2/PSMB5/SLC25A31/RAC2/KLC1/MAPK8/PIK3R1/PRKACA/PSMD8/ATP5F1A/ATF6B	59
KEGG	hsa00510	N-Glycan biosynthesis	11/1759	50/8135	0.5298	0.7232	0.522	ALG6/DPAGT1/FUT8/MAN2A1/B4GALT2/ST6GAL1/MGAT4A/MGAT3/ALG5/B4GALT1/ALG9	11
KEGG	hsa04979	Cholesterol metabolism	11/1759	50/8135	0.5298	0.7232	0.522	APOA1/LRP1/LDLR/VDAC3/LCAT/CYP27A1/ANGPTL4/APOA2/ANGPTL8/LDLRAP1/APOA4	11
KEGG	hsa04721	Synaptic vesicle cycle	17/1759	78/8135	0.53	0.7232	0.522	ATP6V1D/ATP6V1H/ATP6V0E1/CACNA1B/ATP6V1E1/ATP6V1A/CPLX3/NSF/SLC6A11/SLC6A3/SLC18A3/SLC6A7/SLC1A1/ATP6V1B1/STX1A/SLC6A9/SLC6A2	17
KEGG	hsa00512	Mucin type O-glycan biosynthesis	8/1759	36/8135	0.5305	0.7232	0.522	GALNT10/GCNT1/C1GALT1C1/C1GALT1/GALNT6/ST6GALNAC4/GALNT8/ST6GALNAC2	8
KEGG	hsa01240	Biosynthesis of cofactors	33/1759	153/8135	0.5388	0.7316	0.528	GGH/ALAS1/PANK2/TPK1/MAT2B/GCH1/MAT2A/NME6/BCAT2/CPOX/RDH11/PPCS/IDO1/KMO/UGT2B17/HPD/PNPO/ALPI/OXSM/COQ7/HAAO/COX15/RFK/MOCS2/SHMT1/NADK/KYNU/CMPK1/UGT2B4/DLD/PDXK/TDO2/GSS	33
KEGG	hsa04922	Glucagon signaling pathway	23/1759	107/8135	0.5512	0.7454	0.538	PRKACB/AKT2/PGAM1/ITPR2/GCGR/SLC2A2/CREBBP/GCK/CREB3/G6PC3/ITPR1/PPP3CC/GYS1/PHKG1/PPP3CB/CALML3/CALM1/CAMK2B/CPT1A/ACACB/PRKAA2/PRKACA/PHKB	23
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	8/1759	37/8135	0.5647	0.7605	0.5489	PIK3CA/PRKCB/PIK3CB/SGK1/MAPK1/ATP1B2/ATP1B3/PIK3R1	8
KEGG	hsa00511	Other glycan degradation	4/1759	18/8135	0.5673	0.7607	0.549	AGA/MAN2B1/HEXB/NEU2	4
KEGG	hsa00380	Tryptophan metabolism	9/1759	42/8135	0.5729	0.7607	0.549	HADHA/DHTKD1/IDO1/KMO/HAAO/CYP1B1/KYNU/DLD/TDO2	9
KEGG	hsa00590	Arachidonic acid metabolism	13/1759	61/8135	0.5741	0.7607	0.549	LTA4H/PLA2G6/PLA2G4A/PLA2G2D/ALOX12B/HPGDS/PTGS2/PLA2G2E/CYP2E1/CBR3/PLA2G4C/GPX3/PLA2G12A	13
KEGG	hsa00515	Mannose type O-glycan biosynthesis	5/1759	23/8135	0.5762	0.7607	0.549	FUT4/B4GALT2/B4GALT1/POMT2/POMGNT1	5
KEGG	hsa03060	Protein export	5/1759	23/8135	0.5762	0.7607	0.549	SRPRA/SEC63/SPCS1/SPCS2/SPCS3	5
KEGG	hsa01232	Nucleotide metabolism	18/1759	85/8135	0.5828	0.7664	0.5531	DCK/CANT1/NME6/ENTPD1/RRM2/ENTPD2/AMPD1/TYMS/ADA2/DGUOK/AMPD3/GMPR2/DCTD/ADA/GMPR/CMPK1/RRM1/GMPS	18
KEGG	hsa05410	Hypertrophic cardiomyopathy	19/1759	90/8135	0.5888	0.7712	0.5566	ITGB4/ITGA7/ITGA4/SGCA/AGT/CACNG2/MYBPC3/TGFB2/TPM3/ITGB3/EMD/MYL3/CACNG5/CACNG1/CACNA1S/ITGB7/IL6/ATP2A3/PRKAA2	19
KEGG	hsa04975	Fat digestion and absorption	9/1759	43/8135	0.6038	0.7877	0.5685	APOA1/GOT2/PLA2G2D/CEL/PLA2G2E/PLPP3/FABP1/PLA2G12A/APOA4	9
KEGG	hsa04723	Retrograde endocannabinoid signaling	31/1759	148/8135	0.6124	0.7943	0.5732	MAPK9/PRKACB/GNAI3/NDUFA9/MAPK14/ADCY6/GNG3/NDUFS3/NDUFS1/ADCY7/PRKCB/CACNA1B/ITPR2/PTGS2/DAGLA/CNR1/CACNA1S/GNAI2/NDUFS7/ADCY1/MAPK1/FAAH/ITPR1/GABRD/GNB3/NDUFA8/ADCY8/GABRR1/GABRR2/MAPK8/PRKACA	31
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1759	19/8135	0.6136	0.7943	0.5732	IDH3B/GOT2/BCAT2/IDH2	4
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1759	24/8135	0.6171	0.7958	0.5744	HS6ST1/HS2ST1/EXTL1/GLCE/EXTL3	5
KEGG	hsa04744	Phototransduction	6/1759	29/8135	0.6211	0.7979	0.5758	GUCY2D/GRK1/CALML3/CALM1/GNAT1/GUCA1B	6
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1759	49/8135	0.6376	0.8159	0.5889	UXS1/FPGT/CMAS/NAGK/GPI/GALK2/CYB5R4/GCK/GFPT1/HEXB	10
KEGG	hsa04530	Tight junction	35/1759	169/8135	0.6446	0.8217	0.593	MAPK9/PRKACB/MAP2K7/RAB8A/PCNA/MPP5/EZR/PRKCZ/JUN/LLGL2/ACTR2/ARPC5/PPP2CB/YBX3/RAP2C/AFDN/STK11/CLDN11/MAGI1/RAPGEF6/MYL6/ARHGEF18/ROCK1/TUBA8/RAC1/TUBA1A/PRKCE/PPP2R1A/PPP2CA/PPP2R1B/ACTR3/SYNPO/MAPK8/PRKAA2/PRKACA	35
KEGG	hsa00564	Glycerophospholipid metabolism	20/1759	98/8135	0.6546	0.824	0.5947	CHKA/ETNK1/CDS2/PLA2G6/GNPAT/PLA2G4A/PLA2G2D/PTDSS1/LCAT/AGPAT3/PNPLA6/DGKQ/PLA2G2E/PLPP3/CHAT/PLA2G4C/LPCAT4/PEMT/PLA2G12A/PLD1	20
KEGG	hsa05415	Diabetic cardiomyopathy	42/1759	203/8135	0.6555	0.824	0.5947	MAPK9/AKT2/NDUFA9/PDK3/ATP5PB/MAPK14/TGFBR2/PARP1/PRKCZ/NDUFS3/NDUFS1/PIK3CA/VDAC3/PRKCB/AGT/PIK3CB/SMAD2/TGFB2/SDHA/PRKCD/PPP1CA/CMA1/NDUFS7/RAC1/UQCRC1/NCF4/TBC1D4/GFPT1/GYS1/PDK2/NDUFA8/PPIF/ATP5PD/CAMK2B/COX6A2/SLC25A31/RAC2/NFKB1/ATP2A3/MAPK8/PIK3R1/ATP5F1A	42
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/1759	30/8135	0.6562	0.824	0.5947	IDH3B/OGDHL/IDH2/SDHA/MDH1/DLD	6
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1759	30/8135	0.6562	0.824	0.5947	GLDC/SHMT1/HYI/MDH1/HAO2/DLD	6
KEGG	hsa03320	PPAR signaling pathway	15/1759	75/8135	0.6783	0.8485	0.6124	APOA1/ACSL5/RXRB/UBC/ME1/CYP27A1/FABP6/ACSL6/ANGPTL4/ACSL3/NR1H3/APOA2/MMP1/CPT1A/FABP1	15
KEGG	hsa04610	Complement and coagulation cascades	17/1759	85/8135	0.6839	0.8523	0.6151	F7/C7/ITGB2/C8G/MASP1/F10/F9/PLG/THBD/F2R/CR1/C3AR1/PROS1/CD46/C4BPA/PLAU/FGG	17
KEGG	hsa00500	Starch and sucrose metabolism	7/1759	36/8135	0.6884	0.8539	0.6163	GYG1/AGL/GPI/GCK/G6PC3/GBA3/GYS1	7
KEGG	hsa00270	Cysteine and methionine metabolism	10/1759	51/8135	0.6903	0.8539	0.6163	DNMT1/MAT2B/GOT2/MAT2A/BCAT2/SDS/APIP/BHMT2/MDH1/GSS	10
KEGG	hsa00770	Pantothenate and CoA biosynthesis	4/1759	21/8135	0.6962	0.8581	0.6193	PANK2/BCAT2/PPCS/VNN1	4
KEGG	hsa05014	Amyotrophic lateral sclerosis	75/1759	364/8135	0.7054	0.8658	0.6248	BCL2L1/FIG4/HDAC6/RAB8A/TPR/NDUFA9/ACTR10/ATP5PB/MAPK14/HAP1/GRIN2C/FUS/OPTN/SPG11/PSMC2/NUP37/NDUFS3/NDUFS1/CASP1/ATG2B/NXT2/POM121/NUP85/NUP107/DCTN3/CASP3/SDHA/PSMD3/TBK1/DNAH9/NUP133/TNFRSF1B/TUBA8/TOMM40/SQSTM1/DNAL4/HNRNPA1/TUBB/ATG13/PSMD4/PSMA5/NXF3/TP53/NDUFS7/RAC1/DNAH17/WIPI1/SETX/PSMB4/TUBA1A/TUBB2A/PSMA4/UQCRC1/PPP3CC/DNAH6/TNFRSF1A/NDUFA8/PPP3CB/PSMB7/ATP5PD/NDC1/PSMA2/DNAI1/COX6A2/PSMB5/ERN1/GPX3/SEC13/SRSF7/ATXN2L/KLC1/NUP93/PSMD8/ATP5F1A/ULK1	75
KEGG	hsa05150	Staphylococcus aureus infection	19/1759	96/8135	0.7077	0.8658	0.6248	FCGR2B/KRT33A/HLA-DOB/ITGB2/DEFA6/KRT32/MASP1/KRT13/HLA-DMB/IL10/PLG/HLA-DPB1/CAMP/HLA-DPA1/HLA-DMA/C3AR1/FGG/ITGAL/HLA-DQB1	19
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	43/1759	212/8135	0.7102	0.8658	0.6248	JAK2/PRKACB/AKT2/GNAI3/ADCY6/JUN/CCND3/RXRB/PIK3CA/ADCY7/PRKCB/CACNA1B/STAT5A/UGT2B17/PIK3CB/CDC6/RPS6KA1/FOS/KLF4/FGF5/HSP90AA1/AR/EGFR/CACNA1S/CREB3/GNAI2/NRAS/ADCY1/MAPK1/MYC/CYP1B1/FGF17/BCL6/EPHX3/ADCY8/NFKB1/UGT2B4/PIK3R1/PRKACA/WNT1/AIP/AHR/ATF6B	43
KEGG	hsa04973	Carbohydrate digestion and absorption	9/1759	47/8135	0.7149	0.8677	0.6262	AKT2/PIK3CA/PRKCB/PIK3CB/SLC2A2/G6PC3/ATP1B2/ATP1B3/PIK3R1	9
KEGG	hsa05100	Bacterial invasion of epithelial cells	15/1759	77/8135	0.7192	0.8677	0.6262	CTNNB1/ELMO1/ACTR2/ARPC5/PIK3CA/PXN/PIK3CB/CTNNA1/FN1/WASL/RAC1/CD2AP/SHC1/ACTR3/PIK3R1	15
KEGG	hsa04714	Thermogenesis	47/1759	232/8135	0.7202	0.8677	0.6262	PRKACB/FGFR1/NDUFA9/ACSL5/ATP5PB/MAPK14/ARID1A/ADCY6/FGF21/NDUFS3/NDUFS1/ADCY7/KDM3A/NDUFAF1/PNPLA2/FRS2/RPS6KA1/SMARCA4/DPF1/SDHA/PRDM16/CNR1/COA7/COX15/CREB3/NRAS/NDUFS7/ADCY1/BMP8A/NPPB/ACSL6/SLC25A20/UQCRC1/ACSL3/RHEB/PRKG1/NDUFA8/ATP5ME/ATP5PD/COX6A2/CPT1A/ADCY8/RPS6/PRKAA2/PRKACA/KDM3B/ATP5F1A	47
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1759	11/8135	0.7236	0.8677	0.6262	HPD/COQ7	2
KEGG	hsa00062	Fatty acid elongation	5/1759	27/8135	0.7248	0.8677	0.6262	HADHA/ACOT7/ELOVL4/MECR/HSD17B12	5
KEGG	hsa00340	Histidine metabolism	4/1759	22/8135	0.7325	0.8737	0.6306	ALDH3A1/HDC/FTCD/CNDP2	4
KEGG	hsa05016	Huntington disease	62/1759	306/8135	0.7432	0.8796	0.6349	MAPK9/MAP2K7/POLR2F/NDUFA9/ACTR10/ATP5PB/HAP1/PSMC2/NDUFS3/NDUFS1/VDAC3/CACNA1B/ATG2B/DCTN3/CASP3/SDHA/PSMD3/DNAH9/TUBA8/DNAL4/TUBB/ATG13/PSMD4/CREBBP/PSMA5/CREB3/TP53/NDUFS7/DNAH17/WIPI1/PSMB4/TUBA1A/TUBB2A/MAP3K10/ITPR1/PSMA4/UQCRC1/DNAH6/NDUFA8/STX1A/TGM2/PPIF/HIP1/PSMB7/BDNF/ATP5PD/PSMA2/RCOR1/DNAI1/COX6A2/PSMB5/ERN1/SLC25A31/GPX3/POLR2E/TFAM/KLC1/MAPK8/PSMD8/ATP5F1A/HDAC1/ULK1	62
KEGG	hsa04974	Protein digestion and absorption	20/1759	103/8135	0.7437	0.8796	0.6349	SLC7A8/COL6A1/SLC3A2/KCNN4/COL11A2/COL8A1/PRSS2/CELA3A/COL14A1/MEP1B/SLC1A1/ATP1B2/CPA1/ATP1B3/CELA2B/CTRB2/COL17A1/SLC1A5/COL4A3/COL19A1	20
KEGG	hsa00120	Primary bile acid biosynthesis	3/1759	17/8135	0.7453	0.8796	0.6349	CYP27A1/CYP7B1/CYP46A1	3
KEGG	hsa00051	Fructose and mannose metabolism	6/1759	33/8135	0.7487	0.8805	0.6355	FPGT/AKR1B10/TPI1/ALDOC/PFKFB4/TIGAR	6
KEGG	hsa04371	Apelin signaling pathway	27/1759	139/8135	0.7673	0.8985	0.6485	PRKACB/EGR1/AKT2/GNAI3/ADCY6/GNG3/ADCY7/RYR1/SMAD2/ITPR2/PIK3R5/MYL3/GNAI2/NRAS/ADCY1/MAPK1/PRKCE/ITPR1/GNB3/RRAS/CALML3/CALM1/TFAM/ADCY8/RPS6/PRKAA2/PRKACA	27
KEGG	hsa00513	Various types of N-glycan biosynthesis	7/1759	39/8135	0.7694	0.8985	0.6485	FUT8/MAN2A1/B4GALT2/MGAT4A/B4GALT1/HEXB/ALG9	7
KEGG	hsa04080	Neuroactive ligand-receptor interaction	70/1759	353/8135	0.8161	0.9476	0.6839	GRIN2C/PTGER1/GALR1/VIPR2/GZMA/TACR2/NR3C1/CHRNE/SSTR1/OPRL1/CHRNG/AGT/LTB4R/EDNRB/HTR6/P2RX6/NPFFR1/GRM4/CSH1/SSTR3/NTSR2/GCGR/CTSG/PRSS2/CNR1/ADRA2B/EDN2/GALR3/UTS2/SLURP1/CALCA/S1PR5/AVP/DRD3/PENK/PLG/CHRNA5/GABRD/ADORA1/NTSR1/GHSR/ADM2/P2RX2/F2R/CHRNB1/AGTR2/ADCYAP1R1/GIPR/SSTR2/AVPR2/FSHB/P2RY2/P2RY6/C3AR1/HCRT/LPAR6/CRH/GNRH2/HRH3/GABRR1/GABRR2/OPRD1/GIP/OPRK1/THRA/SCT/CHRNA10/OPRM1/ADORA2B/ADORA3	70
KEGG	hsa01212	Fatty acid metabolism	10/1759	57/8135	0.8179	0.9476	0.6839	ACSL5/HADHA/OXSM/ACSL6/FASN/ELOVL4/ACSL3/MECR/CPT1A/HSD17B12	10
KEGG	hsa04512	ECM-receptor interaction	16/1759	88/8135	0.8199	0.9476	0.6839	COL6A1/ITGB4/SDC1/ITGA7/HMMR/ITGA4/TNXB/ITGB3/LAMC3/FN1/HSPG2/GP6/ITGB7/GP9/THBS2/COL4A3	16
KEGG	hsa00052	Galactose metabolism	5/1759	31/8135	0.8318	0.9547	0.689	B4GALT2/AKR1B10/GCK/G6PC3/B4GALT1	5
KEGG	hsa00410	beta-Alanine metabolism	5/1759	31/8135	0.8318	0.9547	0.689	HADHA/ALDH3A1/GAD2/HIBCH/CNDP2	5
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1759	53/8135	0.8393	0.9547	0.689	PRKACB/ADCY6/PRKCB/RAB11A/ATP1B2/TRPV5/ATP2B4/ATP1B3/PRKACA	9
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1759	20/8135	0.8398	0.9547	0.689	DSE/UST/CHST3	3
KEGG	hsa04613	Neutrophil extracellular trap formation	36/1759	190/8135	0.8403	0.9547	0.689	PLCG2/AKT2/HDAC6/HDAC3/MAPK14/PIK3CA/VDAC3/SYK/PRKCB/CASP1/TLR8/HAT1/PIK3CB/GSDMD/MAP3K7/ITGB2/TLR7/ITGB3/CTSG/HDAC7/RAC1/MAPK1/ELANE/NCF4/CR1/CAMP/PPIF/SLC25A31/AZU1/RAC2/NFKB1/PIK3R1/PLCG1/FGG/HDAC1/ITGAL	36
KEGG	hsa00860	Porphyrin metabolism	7/1759	43/8135	0.8518	0.9644	0.696	ALAS1/CPOX/UGT2B17/COX15/HMOX1/BLVRA/UGT2B4	7
KEGG	hsa04978	Mineral absorption	10/1759	60/8135	0.8646	0.9721	0.7016	ATOX1/STEAP1/FTL/HMOX1/SLC31A1/ATP1B2/ATP2B4/SLC30A1/TRPV6/ATP1B3	10
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	42/1759	223/8135	0.867	0.9721	0.7016	MAPK9/AKT2/MAP2K7/NDUFA9/ATP5PB/MAPK14/JUN/NDUFS3/NDUFS1/PIK3CA/VDAC3/PIK3CB/MAP2K4/PRKD2/FOS/SDHA/SLC26A1/PRKCD/EGFR/ARAF/NRAS/NDUFS7/RAC1/HMOX1/MAPK1/CYP2E1/PTPN1/NOX4/UQCRC1/CYP1B1/NDUFA8/PPIF/ATP5PD/COX6A2/SLC25A31/EPHX3/NFKB1/MAPK8/PIK3R1/PLD1/ATP5F1A/AHR	42
KEGG	hsa00730	Thiamine metabolism	2/1759	15/8135	0.8673	0.9721	0.7016	TPK1/ALPI	2
KEGG	hsa00220	Arginine biosynthesis	3/1759	22/8135	0.8844	0.988	0.713	GOT2/ASL/GLUD1	3
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/1759	16/8135	0.8904	0.9914	0.7155	ADO/GAD2	2
KEGG	hsa03040	Spliceosome	26/1759	147/8135	0.9004	0.9959	0.7188	DDX23/CRNKL1/FUS/HNRNPU/SF3B1/CDC40/PPIE/DHX38/SNRNP70/DDX46/CTNNBL1/PRPF6/HNRNPA1/PRPF18/USP39/SRSF5/SYF2/DHX8/HNRNPK/HSPA1L/TRA2B/SRSF7/ACIN1/THOC2/TRA2A/U2AF2	26
KEGG	hsa04392	Hippo signaling pathway - multiple species	4/1759	29/8135	0.9008	0.9959	0.7188	FRMD1/PAK1/RASSF2/WWTR1	4
KEGG	hsa00240	Pyrimidine metabolism	9/1759	58/8135	0.9065	0.9959	0.7188	DCK/CANT1/NME6/ENTPD1/RRM2/TYMS/DCTD/CMPK1/RRM1	9
KEGG	hsa00480	Glutathione metabolism	9/1759	58/8135	0.9065	0.9959	0.7188	LAP3/RRM2/HPGDS/IDH2/NAT8B/GSTK1/GPX3/RRM1/GSS	9
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	5/1759	37/8135	0.9265	1	0.7217	GOT2/ASL/GLUD1/GAD2/GFPT1	5
KEGG	hsa00071	Fatty acid degradation	6/1759	43/8135	0.9274	1	0.7217	ACSL5/HADHA/ACSL6/ACSL3/CPT1A/ADH6	6
KEGG	hsa00140	Steroid hormone biosynthesis	9/1759	61/8135	0.9341	1	0.7217	SRD5A1/HSD17B1/UGT2B17/CYP7B1/CYP17A1/CYP2E1/CYP1B1/HSD17B12/UGT2B4	9
KEGG	hsa03010	Ribosome	27/1759	158/8135	0.9359	1	0.7217	RPL37A/MRPL18/MRPL16/RPL35A/MRPS14/RPS23/RPS12/RPL9/RPS4Y1/RPS5/MRPL22/RPL41/RPL39/RPS8/RPL18/RPL7/MRPL13/MRPS12/RPS28/MRPL11/RPS6/MRPL19/RPL38/RPS2/MRPL17/MRPL34/RPS27L	27
KEGG	hsa00640	Propanoate metabolism	4/1759	32/8135	0.938	1	0.7217	HADHA/HIBCH/ACACB/DLD	4
KEGG	hsa00531	Glycosaminoglycan degradation	2/1759	19/8135	0.9393	1	0.7217	IDS/HEXB	2
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/1759	27/8135	0.9514	1	0.7217	ACOT7/ELOVL4/HSD17B12	3
KEGG	hsa05033	Nicotine addiction	5/1759	40/8135	0.9531	1	0.7217	GRIN2C/CACNA1B/GABRD/GABRR1/GABRR2	5
KEGG	hsa04260	Cardiac muscle contraction	13/1759	87/8135	0.9559	1	0.7217	SLC9A6/ASPH/CACNG2/TPM3/MYL3/CACNG5/CACNG1/CACNA1S/UQCRC1/ATP1B2/ATP1B3/COX6A2/ATP2A3	13
KEGG	hsa00620	Pyruvate metabolism	6/1759	47/8135	0.9587	1	0.7217	ME1/MDH1/PKLR/ADH6/ACACB/DLD	6
KEGG	hsa00650	Butanoate metabolism	3/1759	28/8135	0.9594	1	0.7217	HADHA/GAD2/HMGCL	3
KEGG	hsa00190	Oxidative phosphorylation	21/1759	134/8135	0.9674	1	0.7217	ATP6V1D/NDUFA9/ATP5PB/ATP6V1H/ATP6V0E1/NDUFS3/NDUFS1/ATP6V1E1/ATP4A/ATP6V1A/SDHA/COX15/NDUFS7/ATP6AP1/UQCRC1/NDUFA8/ATP5ME/ATP6V1B1/ATP5PD/COX6A2/ATP5F1A	21
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	4/1759	36/8135	0.9679	1	0.7217	CD38/NNT/SIRT7/NADK	4
KEGG	hsa04742	Taste transduction	12/1759	86/8135	0.9742	1	0.7217	PRKACB/PDE1B/ADCY6/ENTPD2/PKD2L1/GRM4/SCN9A/P2RX2/GNB3/SCN3A/ADCY8/PRKACA	12
KEGG	hsa05034	Alcoholism	30/1759	187/8135	0.9783	1	0.7217	PRKACB/GNAI3/HDAC6/HDAC3/GRIN2C/FOSB/GNG3/SLC29A3/TH/HAT1/NTRK2/PKIA/PPP1CA/HDAC7/ARAF/CREB3/GNAI2/NRAS/MAPK1/SLC6A3/GNB3/BDNF/CALML3/CALM1/SHC1/CRH/PRKACA/HDAC1/ADORA2B/ATF6B	30
KEGG	hsa05206	MicroRNAs in cancer	53/1759	310/8135	0.9816	1	0.7217	PLCG2/DNMT1/ATM/EZR/PIK3CA/CCNE2/PRKCB/STMN1/PIK3CB/E2F3/FZD3/TNXB/CASP3/DDIT4/TGFB2/PTGS2/ITGB3/KIF23/CDKN1A/ROCK1/CYP24A1/CDC25B/TIMP3/EGFR/UBE2I/MCL1/CREBBP/EZH2/TP53/NRAS/HMOX1/MAPK1/RPS6KA5/MYC/PRKCE/CCNE1/CDKN1B/HNRNPK/CYP1B1/BAK1/EFNA5/ZEB1/PDGFA/EFNA4/IRS2/SHC1/PLAU/DICER1/NFKB1/PIK3R1/ABCB1/PLCG1/HDAC1	53
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/1759	78/8135	0.9839	1	0.7217	UGT2B17/HPGDS/ALDH3A1/CYP2D6/CYP2E1/CBR3/GSTK1/CYP1B1/ADH6/UGT2B4	10
KEGG	hsa00040	Pentose and glucuronate interconversions	3/1759	34/8135	0.9867	1	0.7217	UGT2B17/AKR1B10/UGT2B4	3
KEGG	hsa00280	Valine, leucine and isoleucine degradation	5/1759	48/8135	0.9869	1	0.7217	BCAT2/HADHA/HIBCH/DLD/HMGCL	5
KEGG	hsa00561	Glycerolipid metabolism	7/1759	61/8135	0.9869	1	0.7217	PNPLA2/CEL/PNPLA3/AGPAT3/DGKQ/AKR1B10/PLPP3	7
KEGG	hsa00983	Drug metabolism - other enzymes	10/1759	80/8135	0.9877	1	0.7217	NAT1/NME6/RRM2/UGT2B17/CYP2E1/TPMT/CMPK1/RRM1/UGT2B4/GMPS	10
KEGG	hsa00830	Retinol metabolism	8/1759	68/8135	0.9882	1	0.7217	RDH16/RDH11/UGT2B17/CYP2W1/RPE65/DHRS9/ADH6/UGT2B4	8
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	8/1759	69/8135	0.9898	1	0.7217	NAT1/UGT2B17/HPGDS/PTGS2/CYP2E1/GSTK1/CYP1B1/UGT2B4	8
KEGG	hsa00330	Arginine and proline metabolism	5/1759	51/8135	0.9921	1	0.7217	LAP3/GOT2/SAT1/P4HA1/CNDP2	5
KEGG	hsa00982	Drug metabolism - cytochrome P450	8/1759	72/8135	0.9935	1	0.7217	UGT2B17/HPGDS/ALDH3A1/CYP2D6/CYP2E1/GSTK1/ADH6/UGT2B4	8
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/1759	30/8135	0.9939	1	0.7217	UGT2B17/UGT2B4	2
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	6/1759	66/8135	0.998	1	0.7217	FARS2/HARS2/IARS2/QRSL1/FARSA/NARS2	6
KEGG	hsa05322	Systemic lupus erythematosus	16/1759	136/8135	0.9991	1	0.7217	TRIM21/HLA-DOB/C7/CD40/C8G/CD86/CTSG/HLA-DMB/IL10/ELANE/HLA-DPB1/HLA-DPA1/CD40LG/HLA-DMA/IFNG/HLA-DQB1	16
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	11/1759	109/8135	0.9995	1	0.7217	POP5/RPP30/POP4/XPO1/NXT2/WDR43/NXF3/DROSHA/IMP3/FCF1/NMD3	11
KEGG	hsa04740	Olfactory transduction	19/1759	440/8135	1	1	0.7217	PRKACB/OR1F1/PDE1B/OR10H1/OR7A17/GRK2/OR3A3/GUCY2D/OR7C1/GRK3/OR3A1/OR2H2/PRKG1/CALML3/CALM1/NCALD/CAMK2B/OR10H2/PRKACA	19