ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04141	Protein processing in endoplasmic reticulum	39/949	171/8135	2.398e-05	0.007842	0.007776	UBXN6/ERO1A/UBE2G1/FBXO6/LMAN1/SEC24A/ATF6/STUB1/DNAJB11/UBE2J1/XBP1/YOD1/RNF185/SELENOS/DERL1/SAR1B/UBQLN1/SEC62/DNAJC5/SVIP/PLAA/HSPH1/HSPA1L/MBTPS2/ERLEC1/MAP2K7/SEC61A1/HSPA5/DNAJC1/ERO1B/BAG1/EDEM3/MAPK8/DNAJC5B/FBXO2/DERL2/UBE2D3/MAPK9/PDIA3	39
KEGG	hsa04120	Ubiquitin mediated proteolysis	33/949	142/8135	6.752e-05	0.01104	0.01094	UBE2G1/TRAF6/SOCS3/UBE2K/STUB1/FBXO4/MDM2/UBE2I/UBE2J1/CDC23/BIRC3/KLHL9/BIRC6/CUL5/UBE2F/UBE2W/UBE2Q2/MAP3K1/UBE2B/SIAH1/CDC26/ANAPC7/COP1/CBLB/ELOB/UBE2H/UBE2E2/UBE2Q1/FBXO2/UBE2D3/ANAPC10/TRIM32/XIAP	33
KEGG	hsa04340	Hedgehog signaling pathway	15/949	56/8135	0.001444	0.121	0.12	GRK3/SPOPL/KIF7/SUFU/GAS1/SPOP/PTCH1/EVC/KIF3A/DISP1/CDON/CSNK1E/CCND2/EFCAB7/GPR161	15
KEGG	hsa03018	RNA degradation	19/949	79/8135	0.00148	0.121	0.12	LSM8/XRN1/PNPT1/CNOT7/C1D/DCP1A/DIS3/CNOT6L/EDC3/MTREX/CNOT10/TOB1/TOB2/EXOSC1/CNOT9/DCP1B/EXOSC6/CNOT6/XRN2	19
KEGG	hsa04150	mTOR signaling pathway	31/949	156/8135	0.001906	0.1247	0.1236	EIF4E2/FLCN/RPS6KA3/NRAS/FZD3/RRAGC/ATP6V1G3/WDR24/CASTOR2/RHEB/INSR/FZD1/LPIN3/NPRL3/SEH1L/RPS6KB1/PIK3R2/LRP5/LAMTOR3/WNT5B/MAPKAP1/WNT7B/AKT3/CASTOR1/CLIP1/SLC38A9/FZD4/PTEN/ATP6V1C1/STRADB/ATP6V1G1	31
KEGG	hsa03013	Nucleocytoplasmic transport	23/949	108/8135	0.002828	0.1254	0.1243	KPNA4/GLE1/TNPO2/XPOT/TMEM33/UBE2I/TNPO1/IPO8/KPNA6/NDC1/RANBP2/SEH1L/KPNA5/THOC2/THOC7/RBM8A/RNPS1/NUP43/XPO4/NUP93/NUP35/AHCTF1/NUP58	23
KEGG	hsa05168	Herpes simplex virus 1 infection	78/949	495/8135	0.002942	0.1254	0.1243	ZNF517/TAP2/ZNF418/ZFP57/IFNAR2/TRAF6/ZNF101/ZNF12/FAS/SOCS3/BAD/ZNF688/ZNF347/ZNF398/ZNF224/B2M/HLA-DOA/ZNF558/ZNF627/ZNF286A/TLR9/ZFP82/BIRC3/ZNF33A/ZNF600/ZNF736/ZNF324B/RHEB/ZNF439/ZNF614/ZNF234/ZNF544/DDX58/ZNF709/ZNF708/ZNF793/OAS2/ZNF44/ZNF221/ZNF582/CYCS/ZNF275/PIK3R2/ZNF786/ZNF879/ZNF777/RBAK/ZNF316/STAT1/ZNF552/ZNF529/ZNF615/IFNAR1/ZNF19/ZNF780A/ZNF84/ZNF791/ZNF331/ZNF225/ZNF404/ZNF470/ZNF565/ZNF182/ZNF317/ZNF256/AKT3/ZNF229/ZNF766/ZNF680/ZNF431/ZNF649/ZNF37A/BID/ZNF689/PDIA3/ZNF566/NECTIN2/ZNF540	78
KEGG	hsa04140	Autophagy - animal	28/949	141/8135	0.003118	0.1254	0.1243	SQSTM1/TRAF6/NRAS/BAD/RRAGC/TP53INP2/NRBF2/RAB1A/RAB39B/ATG4C/RHEB/LAMP2/ATG7/RPS6KB1/DAPK3/PIK3R2/WDR41/MRAS/SUPT20H/STX17/HMGB1/MAPK8/PRAP1/AKT3/ATG16L1/PTEN/MAPK9/AMBRA1	28
KEGG	hsa04144	Endocytosis	44/949	251/8135	0.003452	0.1254	0.1243	ARAP1/GRK3/ARFGEF2/VTA1/SMAP2/TRAF6/ARF6/USP8/VPS37A/MDM2/VPS35/RABEP1/AP2A1/ASAP1/SNX3/KIF5B/HSPA1L/SNX6/ZFYVE16/ACTR3/EPN3/ARF1/VPS36/VPS25/AGAP9/PARD6G/GIT2/VPS29/ARFGAP2/MVB12A/RBSN/CBLB/VPS37D/CYTH3/ARPC5L/PDCD6IP/DAB2/RAB10/RAB11FIP3/ACAP3/ARFGAP1/EPN1/SH3KBP1/CDC42	44
KEGG	hsa00564	Glycerophospholipid metabolism	21/949	98/8135	0.003912	0.1279	0.1268	ADPRM/SELENOI/PLA2G4F/ETNK1/PCYT2/LPIN3/LPGAT1/PCYT1A/PNPLA7/PGS1/DGKK/AGPAT5/PLPP5/GPAT4/CDS1/GPD2/DGKQ/GPAT2/LCLAT1/LPCAT2/MBOAT1	21
KEGG	hsa05211	Renal cell carcinoma	16/949	69/8135	0.005001	0.1487	0.1474	FLCN/NRAS/BAD/PAK1/ARAF/CREBBP/PIK3R2/ETS1/ELOB/RAPGEF1/EGLN3/AKT3/RAP1A/PAK3/GAB1/CDC42	16
KEGG	hsa00310	Lysine degradation	14/949	63/8135	0.01225	0.3295	0.3267	KMT5C/SETDB2/KMT2A/NSD2/KMT5B/COLGALT1/DLD/NSD1/KMT5A/PRDM6/DHTKD1/TMLHE/SMYD1/SMYD2	14
KEGG	hsa03060	Protein export	7/949	23/8135	0.0131	0.3295	0.3267	SRP68/SRPRB/SEC62/SPCS3/SEC11C/SEC61A1/HSPA5	7
KEGG	hsa04012	ErbB signaling pathway	17/949	85/8135	0.01754	0.4097	0.4062	ERBB4/NRAS/HBEGF/BAD/PAK1/ARAF/NCK1/RPS6KB1/PIK3R2/MAP2K7/PLCG2/CBLB/MAPK8/AKT3/PAK3/GAB1/MAPK9	17
KEGG	hsa04621	NOD-like receptor signaling pathway	31/949	184/8135	0.02175	0.4741	0.47	GBP1/CARD6/IFNAR2/TAB3/TRAF6/RIPK3/GBP2/ANTXR2/BRCC3/P2RX7/RIPK1/BIRC3/NFKBIB/GBP5/GBP4/SUGT1/OAS2/TRPV2/STAT1/NAMPT/IFNAR1/MCU/MAPK8/NLRP12/DNM1L/ATG16L1/ERBIN/MAPK9/DHX33/PYDC1/XIAP	31
KEGG	hsa04068	FoxO signaling pathway	23/949	131/8135	0.02868	0.5633	0.5585	STAT3/NRAS/PLK3/MDM2/FBXO25/NLK/KLF2/IL7R/INSR/ARAF/CREBBP/PRKAG3/PIK3R2/USP7/BCL6/CDKN2B/MAPK8/CSNK1E/AKT3/CCND2/PTEN/PRKAB2/MAPK9	23
KEGG	hsa05162	Measles	24/949	139/8135	0.03092	0.5633	0.5585	STAT3/IFNAR2/TRAF6/FAS/BAD/TLR9/NFKBIB/DDX58/HSPA1L/CSNK2A2/JAK3/OAS2/CYCS/PIK3R2/CSNK2A1/STAT1/IFNAR1/CBLB/MAPK8/SLAMF1/AKT3/CCND2/BID/MAPK9	24
KEGG	hsa04360	Axon guidance	30/949	182/8135	0.03101	0.5633	0.5585	SSH2/SEMA6D/SEMA4A/SEMA4D/NRAS/FZD3/RGMA/SEMA7A/ROCK1/NTNG2/PAK1/PTCH1/PLXNA2/NTNG1/NFATC2/NCK1/PIK3R2/PARD6G/PLCG2/NEO1/LRRC4/WNT5B/EFNA5/NGEF/EPHB1/PAK3/PLXNA4/NTN4/CDC42/SEMA5B	30
KEGG	hsa04330	Notch signaling pathway	12/949	59/8135	0.03727	0.6415	0.636	DTX3L/DLL3/JAG1/TLE4/CREBBP/NUMBL/DTX3/NOTCH4/DLL4/DLL1/APH1B/NCOR2	12
KEGG	hsa05110	Vibrio cholerae infection	10/949	50/8135	0.06004	0.9335	0.9256	ERO1A/ATP6V1G3/ATP6V0E1/ATP6V0B/ARF1/CFTR/PLCG2/SEC61A1/ATP6V1C1/ATP6V1G1	10
KEGG	hsa04710	Circadian rhythm	7/949	31/8135	0.06192	0.9335	0.9256	FBXL3/PRKAG3/RORC/CLOCK/CSNK1E/BHLHE41/PRKAB2	7
KEGG	hsa05169	Epstein-Barr virus infection	31/949	202/8135	0.06577	0.9335	0.9256	TAP2/STAT3/IFNAR2/TRAF6/SAP30L/FAS/MDM2/B2M/HLA-DOA/RIPK1/NFKBIB/DDX58/JAK3/OAS2/CYCS/PIK3R2/MAP2K7/USP7/PLCG2/ENTPD1/STAT1/IFNAR1/MAPK8/RUNX3/POLK/AKT3/CCND2/BID/MAPK9/NCOR2/PDIA3	31
KEGG	hsa04137	Mitophagy - animal	13/949	72/8135	0.07122	0.9335	0.9256	SQSTM1/CITED2/NRAS/USP8/CSNK2A2/MRAS/CSNK2A1/RHOT1/MAPK8/TBC1D15/MAPK9/CALCOCO2/AMBRA1	13
KEGG	hsa04215	Apoptosis - multiple species	7/949	32/8135	0.07163	0.9335	0.9256	BIRC3/BIRC6/CYCS/MAPK8/BID/MAPK9/XIAP	7
KEGG	hsa04931	Insulin resistance	18/949	108/8135	0.07445	0.9335	0.9256	STAT3/RPS6KA3/SOCS3/CRTC2/SLC27A5/PPP1R3E/INSR/CREB5/PRKAG3/RPS6KB1/PIK3R2/MAPK8/AKT3/PPP1R3C/PTEN/PRKAB2/MAPK9/PPP1R3B	18
KEGG	hsa05205	Proteoglycans in cancer	31/949	205/8135	0.07691	0.9335	0.9256	STAT3/ERBB4/NRAS/FZD3/HBEGF/FAS/MDM2/ROCK1/PAK1/PPP1R12C/PTCH1/FZD1/ITGA2/ARAF/RPS6KB1/PIK3R2/ANK3/MRAS/PLCG2/WNT5B/FRS2/NUDT16L1/MIR10A/LUM/WNT7B/AKT3/RDX/FZD4/TWIST2/GAB1/CDC42	31
KEGG	hsa04115	p53 signaling pathway	13/949	73/8135	0.07785	0.9335	0.9256	FAS/GTSE1/GORAB/MDM2/RRM2B/ZMAT3/CYCS/SIAH1/COP1/TNFRSF10A/CCND2/BID/PTEN	13
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	18/949	109/8135	0.07993	0.9335	0.9256	XRN1/LSG1/UTP15/RIOK2/RPP25/WDR75/FCF1/UTP4/RPP25L/CSNK2A2/RIOK1/WDR36/CSNK2A1/FBLL1/HEATR1/SNU13/TCOF1/XRN2	18
KEGG	hsa04932	Non-alcoholic fatty liver disease	24/949	155/8135	0.08906	0.9698	0.9615	NDUFA12/FAS/SOCS3/XBP1/NDUFS7/INSR/PRKAG3/CYCS/PIK3R2/NDUFB2/IL6R/MAPK8/COX8C/UQCR10/COX7B/AKT3/NDUFA11/COX6A1/BID/UQCR11/PRKAB2/MAPK9/CDC42/COX4I1	24
KEGG	hsa04070	Phosphatidylinositol signaling system	16/949	97/8135	0.09548	0.9698	0.9615	IMPAD1/ITPKB/PIP4P1/INPP4A/PIK3R2/DGKK/PLCD4/PLCG2/CDS1/DGKQ/PIP4P2/PLCZ1/PTEN/PLCD3/IP6K3/MTMR7	16
KEGG	hsa04668	TNF signaling pathway	18/949	112/8135	0.09794	0.9698	0.9615	TAB3/RIPK3/FAS/SOCS3/RIPK1/BIRC3/JAG1/CREB5/PIK3R2/MAP2K7/DAB2IP/EDN1/MLKL/MAPK8/MAP3K8/AKT3/DNM1L/MAPK9	18
KEGG	hsa05212	Pancreatic cancer	13/949	76/8135	0.1001	0.9698	0.9615	STAT3/BAD/RALBP1/RALA/ARAF/RPS6KB1/PIK3R2/STAT1/MAPK8/POLK/AKT3/MAPK9/CDC42	13
KEGG	hsa05132	Salmonella infection	36/949	249/8135	0.1003	0.9698	0.9615	EXOC5/KPNA4/ARL8B/FBXO22/TAB3/TRAF6/DYNC1LI1/ARF6/RIPK3/TLR9/RIPK1/BIRC3/RALA/PAK1/KIF5B/ACTR3/ARF1/CYCS/AHNAK/MAP2K7/SNX18/EXOC2/PIK3CG/CYTH3/ARPC5L/MLKL/TNFRSF10A/MAPK8/DCTN4/AKT3/TCF7L2/DYNC1I2/TUBB1/PAK3/MAPK9/CDC42	36
KEGG	hsa05010	Alzheimer disease	53/949	384/8135	0.1065	0.9698	0.9615	NRAS/NDUFA12/FZD3/ND4/FAS/BAD/ATF6/CACNA1D/NRBF2/XBP1/ATP2A2/NDUFS7/INSR/FZD1/KIF5B/BACE1/CSNK2A2/ARAF/CYCS/PSMB7/PIK3R2/MAP2K7/BACE2/NDUFB2/SLC39A9/CSNK2A1/PSMB4/LRP5/GRIN2B/SLC39A5/WNT5B/MAPT/MCU/MAPK8/SLC39A11/WNT7B/CSNK1E/APH1B/COX8C/UQCR10/COX7B/AKT3/NDUFA11/COX6A1/TUBB1/BID/UQCR11/FZD4/MAPK9/ATP5PB/CHRM3/AMBRA1/COX4I1	53
KEGG	hsa04919	Thyroid hormone signaling pathway	19/949	121/8135	0.1083	0.9698	0.9615	GATA4/NRAS/MED30/BAD/MDM2/ATP1B3/ATP2A2/RHEB/CREBBP/PIK3R2/PLCD4/PLCG2/STAT1/NOTCH4/ATP1B4/AKT3/PLCZ1/DIO2/PLCD3	19
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/949	70/8135	0.1097	0.9698	0.9615	JAM3/HBEGF/ATP6V1G3/ATP6V0E1/ATP6V0B/PAK1/PLCG2/MAPK8/MAPK9/ATP6V1C1/CDC42/ATP6V1G1	12
KEGG	hsa05130	Pathogenic Escherichia coli infection	29/949	197/8135	0.1097	0.9698	0.9615	TAB3/TRAF6/NCL/ARF6/SEC24A/FAS/ROCK1/RAB1A/CLDN23/RIPK1/NFKBIB/GNA13/PAK1/GNA12/ACTR3/WASF2/ARF1/CYCS/NCK1/MYO5B/NLRP4/CYTH3/ARPC5L/TNFRSF10A/MAPK8/TUBB1/PAK3/MAPK9/CDC42	29
KEGG	hsa04910	Insulin signaling pathway	21/949	137/8135	0.1149	0.9891	0.9807	SOCS4/EIF4E2/NRAS/PRKAR2A/SOCS3/BAD/RHEB/PPP1R3E/INSR/ARAF/PRKAG3/RPS6KB1/PIK3R2/CBLB/RAPGEF1/MAPK8/AKT3/PPP1R3C/PRKAB2/MAPK9/PPP1R3B	21
KEGG	hsa04530	Tight junction	25/949	169/8135	0.1249	1	0.9915	JAM3/GATA4/CACNA1D/ROCK1/CLDN23/RAPGEF6/WHAMM/CRB3/PRKAG3/RAB8B/ACTR3/MAP2K7/PARD6G/SYNPO/CFTR/MAP3K1/MICALL2/ARPC5L/MAPK8/RAP1A/RDX/PRKAB2/MAPK9/YBX3/CDC42	25
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/949	79/8135	0.1257	1	0.9915	STAT3/EIF4E2/NRAS/BAD/PDGFD/ARAF/RPS6KB1/PIK3R2/PLCG2/IL6R/AKT3/PTEN/GAB1	13
KEGG	hsa03040	Spliceosome	22/949	147/8135	0.1309	1	0.9915	LSM8/CCDC12/PPIL1/PRPF40A/EFTUD2/DDX46/SLU7/U2AF2/PRPF38A/HSPA1L/SRSF10/HNRNPC/THOC2/SMNDC1/RBM8A/TRA2B/SF3A1/SNU13/PLRG1/SF3B6/HNRNPU/ZMAT2	22
KEGG	hsa04722	Neurotrophin signaling pathway	18/949	119/8135	0.1492	1	0.9915	TRAF6/RPS6KA3/NRAS/BAD/NFKBIB/PIK3R2/MAP2K7/PLCG2/MAP3K1/CAMK4/FRS2/RAPGEF1/MAPK8/AKT3/RAP1A/GAB1/MAPK9/CDC42	18
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/949	89/8135	0.1503	1	0.9915	STAT3/TRAF6/NRAS/TLR9/NFKBIB/CD274/CSNK2A2/NFATC2/RPS6KB1/PIK3R2/CSNK2A1/STAT1/AKT3/PTEN	14
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	15/949	97/8135	0.1551	1	0.9915	DOCK1/ARF6/PLA2G4F/ASAP1/PAK1/MARCKS/ACTR3/WASF2/RPS6KB1/PIK3R2/PLCG2/ARPC5L/GSN/AKT3/CDC42	15
KEGG	hsa04152	AMPK signaling pathway	18/949	120/8135	0.1575	1	0.9915	CRTC2/PFKFB4/MLYCD/RHEB/INSR/TBC1D1/CREB5/PRKAG3/RPS6KB1/PIK3R2/HNF4A/EEF2/CFTR/SCD5/RAB10/AKT3/PRKAB2/STRADB	18
KEGG	hsa01522	Endocrine resistance	15/949	98/8135	0.1647	1	0.9915	NRAS/HBEGF/BAD/MDM2/DLL3/JAG1/ARAF/RPS6KB1/PIK3R2/NOTCH4/DLL4/DLL1/MAPK8/AKT3/MAPK9	15
KEGG	hsa05231	Choline metabolism in cancer	15/949	98/8135	0.1647	1	0.9915	SLC22A5/NRAS/SLC44A1/PLA2G4F/PDGFD/RHEB/WASF2/RPS6KB1/PIK3R2/PCYT1A/DGKK/DGKQ/MAPK8/AKT3/MAPK9	15
KEGG	hsa00561	Glycerolipid metabolism	10/949	61/8135	0.168	1	0.9915	LPIN3/DGKK/AGPAT5/PLPP5/GPAT4/DGKQ/GPAT2/PNPLA3/LCLAT1/MBOAT1	10
KEGG	hsa04014	Ras signaling pathway	32/949	232/8135	0.1775	1	0.9915	ARF6/NRAS/BAD/PLA2G4F/RALBP1/PDGFD/RALA/PAK1/INSR/GNG12/PIK3R2/REL/GNGT2/MRAS/PLCG2/SYNGAP1/GNG7/GRIN2B/EXOC2/ETS1/RASGRF2/EFNA5/MAPK8/RASSF5/AKT3/RAP1A/PAK3/RASA3/GAB1/MAPK9/RASAL2/CDC42	32
KEGG	hsa04917	Prolactin signaling pathway	11/949	70/8135	0.1879	1	0.9915	SOCS4/STAT3/CGA/NRAS/SOCS3/PIK3R2/STAT1/MAPK8/AKT3/CCND2/MAPK9	11
KEGG	hsa05217	Basal cell carcinoma	10/949	63/8135	0.1941	1	0.9915	FZD3/KIF7/SUFU/PTCH1/FZD1/WNT5B/WNT7B/POLK/TCF7L2/FZD4	10
KEGG	hsa04520	Adherens junction	11/949	71/8135	0.2006	1	0.9915	FARP2/NLK/INSR/CSNK2A2/CREBBP/WASF2/LMO7/CSNK2A1/TCF7L2/CDC42/NECTIN2	11
KEGG	hsa04260	Cardiac muscle contraction	13/949	87/8135	0.2101	1	0.9915	CACNA1D/ATP1B3/ATP2A2/TPM2/SLC8A1/COX8C/ATP1B4/UQCR10/COX7B/COX6A1/UQCR11/COX4I1/TPM3	13
KEGG	hsa05223	Non-small cell lung cancer	11/949	72/8135	0.2136	1	0.9915	STAT3/NRAS/BAD/KIF5B/ARAF/JAK3/PIK3R2/PLCG2/RASSF5/POLK/AKT3	11
KEGG	hsa03010	Ribosome	22/949	158/8135	0.2175	1	0.9915	MRPL14/RPS27/RPLP1/RPL22L1/MRPL36/RPS27L/MRPL12/RPL36A/MRPL32/MRPL4/MRPS5/RPL7/MRPL27/FAU/MRPL35/MRPL21/RPL35/MRPS18C/RPS10/MRPL10/MRPS6/RSL24D1	22
KEGG	hsa00510	N-Glycan biosynthesis	8/949	50/8135	0.2227	1	0.9915	ALG5/MAN2A1/MGAT3/ALG2/ALG14/SRD5A3/B4GALT1/ALG9	8
KEGG	hsa05014	Amyotrophic lateral sclerosis	47/949	364/8135	0.2467	1	0.9915	SQSTM1/ERBB4/GLE1/TARDBP/NDUFA12/ND4/BAD/ATF6/DNAH14/NRBF2/XBP1/RAB1A/RAB39B/DERL1/NDUFS7/UBQLN1/KIF5B/NDC1/RANBP2/SEH1L/CYCS/PSMB7/WDR41/NDUFB2/PSMB4/HSPA5/GRIN2B/MCU/NUP43/DCTN4/COX8C/NUP93/TOMM40L/UQCR10/COX7B/NDUFA11/COX6A1/NUP35/MATR3/TUBB1/BID/UQCR11/ATP5PB/NUP58/AMBRA1/COX4I1/DNAH12	47
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/949	22/8135	0.2502	1	0.9915	NUS1/FNTA/DHDDS/IDI1	4
KEGG	hsa00730	Thiamine metabolism	3/949	15/8135	0.2512	1	0.9915	NTPCR/TPK1/AK4	3
KEGG	hsa00600	Sphingolipid metabolism	8/949	52/8135	0.2562	1	0.9915	CERS5/CERS6/DEGS2/B4GALT6/ACER3/NEU4/SGPP1/SGPP2	8
KEGG	hsa04371	Apelin signaling pathway	19/949	139/8135	0.2645	1	0.9915	NRAS/JAG1/GNA13/KLF2/GNG12/PRKAG3/RPS6KB1/GNGT2/MRAS/GNG7/SLC8A1/PIK3CG/CAMK4/MEF2D/AKT3/EGR1/PRKAB2/MEF2A/TFAM	19
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/949	100/8135	0.2739	1	0.9915	STAT3/NRAS/PIK3R2/PLCD4/PLCG2/STAT1/EDN1/COL4A4/MAPK8/AKT3/EGR1/MAPK9/PLCD3/CDC42	14
KEGG	hsa04072	Phospholipase D signaling pathway	20/949	148/8135	0.2747	1	0.9915	ARF6/NRAS/PLA2G4F/PDGFD/RALA/GNA13/RHEB/GNA12/INSR/ARF1/PIK3R2/DGKK/AGPAT5/MRAS/PLCG2/PIK3CG/DGKQ/CYTH3/AKT3/GAB1	20
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	60/949	476/8135	0.2758	1	0.9915	GRIA3/SQSTM1/UBE2G1/TARDBP/NRAS/NDUFA12/FZD3/ND4/FAS/BAD/ATF6/CACNA1D/DNAH14/UBE2J1/NRBF2/XBP1/RAB1A/RAB39B/ATP2A2/PARK7/DERL1/LRRK2/NDUFS7/FZD1/KIF5B/CSNK2A2/ARAF/CYCS/PSMB7/WDR41/MAP2K7/NDUFB2/CSNK2A1/PSMB4/LRP5/HSPA5/GRIN2B/WNT5B/MAPT/MCU/MAPK8/DCTN4/WNT7B/CSNK1E/COX8C/TOMM40L/UQCR10/COX7B/NDUFA11/COX6A1/TUBB1/BID/UQCR11/FZD4/MAPK9/ATP5PB/CHRM3/AMBRA1/COX4I1/DNAH12	60
KEGG	hsa00515	Mannose type O-glycan biosynthesis	4/949	23/8135	0.2773	1	0.9915	POMGNT1/ST3GAL3/FKRP/B4GALT1	4
KEGG	hsa05160	Hepatitis C	21/949	157/8135	0.2844	1	0.9915	STAT3/IFNAR2/TRAF6/NRAS/FAS/SOCS3/BAD/SCARB1/CLDN23/RIPK1/YWHAG/DDX58/ARAF/OAS2/CYCS/PIK3R2/STAT1/IFNAR1/EIF3E/AKT3/BID	21
KEGG	hsa04930	Type II diabetes mellitus	7/949	46/8135	0.2862	1	0.9915	SOCS4/SOCS3/CACNA1D/INSR/PIK3R2/MAPK8/MAPK9	7
KEGG	hsa04066	HIF-1 signaling pathway	15/949	109/8135	0.2869	1	0.9915	STAT3/PGK1/EIF4E2/PDK1/INSR/CREBBP/RPS6KB1/PIK3R2/PLCG2/IL6R/ALDOA/ELOB/EDN1/EGLN3/AKT3	15
KEGG	hsa03460	Fanconi anemia pathway	8/949	54/8135	0.2911	1	0.9915	RMI2/EME1/FANCF/POLI/REV1/POLK/REV3L/ERCC4	8
KEGG	hsa00190	Oxidative phosphorylation	18/949	134/8135	0.2975	1	0.9915	NDUFA12/ND4/ATP6V1G3/ATP6V0E1/ATP6V0B/NDUFS7/CYCS/NDUFB2/COX8C/UQCR10/COX7B/NDUFA11/COX6A1/UQCR11/ATP6V1C1/ATP5PB/ATP6V1G1/COX4I1	18
KEGG	hsa05210	Colorectal cancer	12/949	86/8135	0.299	1	0.9915	NRAS/BAD/RALA/ARAF/CYCS/RPS6KB1/PIK3R2/MAPK8/POLK/AKT3/TCF7L2/MAPK9	12
KEGG	hsa00513	Various types of N-glycan biosynthesis	6/949	39/8135	0.3001	1	0.9915	MAN2A1/ST3GAL3/ALG2/ALG14/B4GALT1/ALG9	6
KEGG	hsa04310	Wnt signaling pathway	22/949	167/8135	0.3036	1	0.9915	FZD3/NLK/TLE4/FZD1/CSNK2A2/CREBBP/NFATC2/LGR4/CSNK2A1/LRP5/SIAH1/WNT5B/VANGL2/ROR1/MAPK8/WNT7B/CSNK1E/TCF7L2/CCND2/FZD4/MAPK9/NKD2	22
KEGG	hsa04071	Sphingolipid signaling pathway	16/949	119/8135	0.311	1	0.9915	NRAS/ROCK1/GNA13/GNA12/CERS5/CERS6/DEGS2/PIK3R2/S1PR2/MAPK8/AKT3/SGPP1/BID/PTEN/MAPK9/SGPP2	16
KEGG	hsa05145	Toxoplasmosis	15/949	112/8135	0.3245	1	0.9915	STAT3/TRAF6/BAD/HLA-DOA/BIRC3/NFKBIB/LAMB4/HSPA1L/CYCS/STAT1/PIK3CG/MAPK8/AKT3/MAPK9/XIAP	15
KEGG	hsa04625	C-type lectin receptor signaling pathway	14/949	104/8135	0.3257	1	0.9915	NRAS/PLK3/MDM2/CLEC4E/PAK1/NFATC2/PIK3R2/MRAS/PLCG2/STAT1/CBLB/MAPK8/AKT3/MAPK9	14
KEGG	hsa04660	T cell receptor signaling pathway	14/949	104/8135	0.3257	1	0.9915	NRAS/NFKBIB/PAK1/NFATC2/NCK1/PIK3R2/MAP2K7/CBLB/MAPK8/MAP3K8/AKT3/PAK3/MAPK9/CDC42	14
KEGG	hsa00920	Sulfur metabolism	2/949	10/8135	0.3287	1	0.9915	IMPAD1/BPNT1	2
KEGG	hsa05135	Yersinia infection	18/949	137/8135	0.3318	1	0.9915	SKAP2/DOCK1/BCAR1/TRAF6/RPS6KA3/ARF6/ROCK1/ACTR3/NFATC2/WASF2/PIK3R2/MAP2K7/GIT2/ARPC5L/MAPK8/AKT3/MAPK9/CDC42	18
KEGG	hsa05161	Hepatitis B	21/949	162/8135	0.3368	1	0.9915	STAT3/TRAF6/NRAS/FAS/BAD/DDX58/ARAF/CREBBP/JAK3/CREB5/NFATC2/CYCS/PIK3R2/MAP2K7/MAP3K1/STAT1/IFNAR1/MAPK8/AKT3/BID/MAPK9	21
KEGG	hsa04130	SNARE interactions in vesicular transport	5/949	33/8135	0.3396	1	0.9915	VTI1A/VTI1B/STX17/STX11/STX6	5
KEGG	hsa05170	Human immunodeficiency virus 1 infection	27/949	212/8135	0.3425	1	0.9915	TAP2/TRAF6/NRAS/AP1S2/FAS/BAD/B2M/RIPK1/PAK1/GNG12/NFATC2/CYCS/RPS6KB1/CUL5/PIK3R2/MAP2K7/GNGT2/PLCG2/GNG7/TRIM5/ELOB/MAPK8/AKT3/PAK3/BID/MAPK9/PDIA3	27
KEGG	hsa00562	Inositol phosphate metabolism	10/949	73/8135	0.3445	1	0.9915	ITPKB/INPP4A/PLCD4/PLCG2/PIK3CG/PLCZ1/PTEN/PLCD3/MTMR7/MIOX	10
KEGG	hsa01524	Platinum drug resistance	10/949	73/8135	0.3445	1	0.9915	FAS/BAD/MDM2/BIRC3/CYCS/PIK3R2/AKT3/REV3L/BID/XIAP	10
KEGG	hsa05224	Breast cancer	19/949	147/8135	0.3526	1	0.9915	NRAS/FZD3/DLL3/JAG1/FZD1/ARAF/RPS6KB1/PIK3R2/LRP5/NOTCH4/WNT5B/DLL4/DLL1/WNT7B/POLK/AKT3/TCF7L2/FZD4/PTEN	19
KEGG	hsa04146	Peroxisome	11/949	82/8135	0.3588	1	0.9915	ACSL5/MLYCD/PEX5L/PECR/PEX13/CROT/PEX2/FAR2/NUDT19/FAR1/HACL1	11
KEGG	hsa05131	Shigellosis	31/949	247/8135	0.3592	1	0.9915	DOCK1/SQSTM1/BCAR1/TAB3/TRAF6/ARF6/RRAGC/MDM2/ROCK1/RIPK1/NFKBIB/ACTR3/WASF2/ARF1/CYCS/RPS6KB1/PIK3R2/PLCD4/PLCG2/CBX3/CYTH3/ARPC5L/MAPK8/AKT3/ATG16L1/UBE2D3/PLCZ1/MAPK9/CALCOCO2/PLCD3/CDC42	31
KEGG	hsa04218	Cellular senescence	20/949	156/8135	0.3612	1	0.9915	SQSTM1/GATA4/NRAS/CACNA1D/MDM2/RAD1/LIN37/RHEB/NFATC2/PIK3R2/MRAS/LIN54/ETS1/CDKN2B/MCU/RASSF5/AKT3/CCND2/PTEN/HIPK3	20
KEGG	hsa05213	Endometrial cancer	8/949	58/8135	0.3639	1	0.9915	NRAS/BAD/ARAF/PIK3R2/POLK/AKT3/TCF7L2/PTEN	8
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/949	11/8135	0.3733	1	0.9915	COQ5/COQ3	2
KEGG	hsa04714	Thermogenesis	29/949	232/8135	0.3743	1	0.9915	NDUFAF5/RPS6KA3/NRAS/NDUFA12/ND4/ACSL5/NDUFAF4/RHEB/NDUFS7/NDUFAF6/CREB5/PRKAG3/RPS6KB1/NDUFB2/COX18/NDUFAF7/FRS2/COA5/COX8C/UQCR10/COX7B/NDUFA11/COX6A1/COA7/UQCR11/COX14/PRKAB2/ATP5PB/COX4I1	29
KEGG	hsa05171	Coronavirus disease - COVID-19	29/949	232/8135	0.3743	1	0.9915	STAT3/RPS27/RPLP1/IFNAR2/RPL22L1/TRAF6/TLR8/HBEGF/RPS27L/MASP1/NFKBIB/RPL36A/DDX58/RPL7/OAS2/FAU/PIK3R2/VWF/PLCG2/IL6R/STAT1/IFNAR1/RPL35/RPS10/MAPK8/C7/RSL24D1/MAPK9/ACE	29
KEGG	hsa04514	Cell adhesion molecules	19/949	149/8135	0.3756	1	0.9915	JAM3/LRRC4B/NLGN2/CDH4/NRXN1/HLA-DOA/NTNG2/CLDN23/CD274/PDCD1LG2/PVR/NTNG1/CD276/NEO1/LRRC4/NFASC/TIGIT/NECTIN2/CNTN2	19
KEGG	hsa04370	VEGF signaling pathway	8/949	59/8135	0.3824	1	0.9915	NRAS/BAD/PLA2G4F/NFATC2/PIK3R2/PLCG2/AKT3/CDC42	8
KEGG	hsa04658	Th1 and Th2 cell differentiation	12/949	92/8135	0.3863	1	0.9915	HLA-DOA/DLL3/JAG1/NFKBIB/JAK3/NFATC2/STAT1/DLL4/DLL1/MAPK8/RUNX3/MAPK9	12
KEGG	hsa05222	Small cell lung cancer	12/949	92/8135	0.3863	1	0.9915	TRAF6/BIRC3/ITGA2/LAMB4/CYCS/PIK3R2/CDKN2B/COL4A4/POLK/AKT3/PTEN/XIAP	12
KEGG	hsa04966	Collecting duct acid secretion	4/949	27/8135	0.3881	1	0.9915	ATP6V1G3/ATP6V0E1/ATP6V1C1/ATP6V1G1	4
KEGG	hsa04217	Necroptosis	20/949	159/8135	0.395	1	0.9915	SQSTM1/STAT3/IFNAR2/RIPK3/FAS/PLA2G4F/RIPK1/BIRC3/JAK3/FAF1/STAT1/HMGB1/IFNAR1/MLKL/TNFRSF10A/MAPK8/DNM1L/BID/MAPK9/XIAP	20
KEGG	hsa04510	Focal adhesion	25/949	201/8135	0.3976	1	0.9915	ITGB4/DOCK1/BCAR1/BAD/ROCK1/PDGFD/BIRC3/PAK1/PPP1R12C/ITGA2/LAMB4/PIK3R2/VWF/PARVB/RAPGEF1/COL4A4/MAPK8/AKT3/CCND2/RAP1A/PAK3/PTEN/MAPK9/CDC42/XIAP	25
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/949	143/8135	0.4029	1	0.9915	STAT3/NRAS/FZD3/ID4/ZFHX3/FZD1/JAK3/SMARCAD1/PIK3R2/PCGF6/WNT5B/KAT6A/WNT7B/AKT3/PAX6/FZD4/PCGF5/TCF3	18
KEGG	hsa05100	Bacterial invasion of epithelial cells	10/949	77/8135	0.4099	1	0.9915	DOCK1/BCAR1/ACTR3/WASF2/MAD2L2/CD2AP/PIK3R2/ARPC5L/GAB1/CDC42	10
KEGG	hsa04914	Progesterone-mediated oocyte maturation	13/949	102/8135	0.4114	1	0.9915	RPS6KA3/CPEB3/CDC23/ARAF/MAD2L2/PIK3R2/STK10/CDC26/ANAPC7/MAPK8/AKT3/ANAPC10/MAPK9	13
KEGG	hsa04920	Adipocytokine signaling pathway	9/949	69/8135	0.4146	1	0.9915	STAT3/SOCS3/ACSL5/NFKBIB/PRKAG3/MAPK8/AKT3/PRKAB2/MAPK9	9
KEGG	hsa03022	Basal transcription factors	6/949	45/8135	0.4304	1	0.9915	GTF2A1/TAF4B/TAF3/TAF13/GTF2H3/TAF6L	6
KEGG	hsa01250	Biosynthesis of nucleotide sugars	5/949	37/8135	0.4365	1	0.9915	PGM2/UXS1/NANP/GNPNAT1/MIOX	5
KEGG	hsa04213	Longevity regulating pathway - multiple species	8/949	62/8135	0.438	1	0.9915	NRAS/INSR/HSPA1L/PRKAG3/RPS6KB1/PIK3R2/AKT3/PRKAB2	8
KEGG	hsa04620	Toll-like receptor signaling pathway	13/949	104/8135	0.44	1	0.9915	IFNAR2/TRAF6/TLR8/TLR9/RIPK1/PIK3R2/MAP2K7/STAT1/IFNAR1/MAPK8/MAP3K8/AKT3/MAPK9	13
KEGG	hsa04392	Hippo signaling pathway - multiple species	4/949	29/8135	0.4431	1	0.9915	PAK1/MOB1B/CSNK1E/TEAD2	4
KEGG	hsa03250	Viral life cycle - HIV-1	8/949	63/8135	0.4565	1	0.9915	NELFCD/CREBBP/RANBP2/BICD1/TRIM5/PDCD6IP/CCNT2/CPSF6	8
KEGG	hsa03450	Non-homologous end-joining	2/949	13/8135	0.4584	1	0.9915	DCLRE1C/LIG4	2
KEGG	hsa05340	Primary immunodeficiency	5/949	38/8135	0.4603	1	0.9915	TAP2/DCLRE1C/IL7R/JAK3/AICDA	5
KEGG	hsa05215	Prostate cancer	12/949	97/8135	0.4608	1	0.9915	NRAS/BAD/MDM2/PDGFD/ARAF/CREBBP/CREB5/PIK3R2/AKT3/TCF7L2/PTEN/ETV5	12
KEGG	hsa05218	Melanoma	9/949	72/8135	0.4665	1	0.9915	NRAS/BAD/MDM2/PDGFD/ARAF/PIK3R2/POLK/AKT3/PTEN	9
KEGG	hsa04211	Longevity regulating pathway	11/949	89/8135	0.4678	1	0.9915	EIF4E2/NRAS/RHEB/INSR/CREB5/PRKAG3/RPS6KB1/PIK3R2/CAMK4/AKT3/PRKAB2	11
KEGG	hsa00030	Pentose phosphate pathway	4/949	30/8135	0.4701	1	0.9915	PRPS2/PGM2/RPE/ALDOA	4
KEGG	hsa01523	Antifolate resistance	4/949	30/8135	0.4701	1	0.9915	MTHFR/ABCC4/SLC19A1/ABCC3	4
KEGG	hsa05410	Hypertrophic cardiomyopathy	11/949	90/8135	0.4832	1	0.9915	ITGB4/CACNA1D/ATP2A2/ITGA2/TPM2/PRKAG3/SLC8A1/EDN1/PRKAB2/ACE/TPM3	11
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/949	14/8135	0.4984	1	0.9915	ST3GAL3/B4GALT1	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	3/949	23/8135	0.5129	1	0.9915	ATP1B3/GLS/ATP1B4	3
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	6/949	49/8135	0.5155	1	0.9915	PGM2/GNPDA2/UXS1/NANP/GNPNAT1/CYB5R4	6
KEGG	hsa05214	Glioma	9/949	75/8135	0.5176	1	0.9915	NRAS/MDM2/ARAF/PIK3R2/PLCG2/CAMK4/POLK/AKT3/PTEN	9
KEGG	hsa05221	Acute myeloid leukemia	8/949	67/8135	0.5288	1	0.9915	STAT3/NRAS/BAD/ARAF/RPS6KB1/PIK3R2/AKT3/TCF7L2	8
KEGG	hsa04912	GnRH signaling pathway	11/949	93/8135	0.5289	1	0.9915	CGA/NRAS/HBEGF/CACNA1D/PLA2G4F/MAP2K7/MAP3K1/MAPK8/EGR1/MAPK9/CDC42	11
KEGG	hsa04935	Growth hormone synthesis, secretion and action	14/949	119/8135	0.5295	1	0.9915	STAT3/BCAR1/NRAS/SOCS3/CACNA1D/CREBBP/CREB5/PIK3R2/PLCG2/MAP3K1/STAT1/MAPK8/AKT3/MAPK9	14
KEGG	hsa05219	Bladder cancer	5/949	41/8135	0.5299	1	0.9915	NRAS/HBEGF/MDM2/ARAF/DAPK3	5
KEGG	hsa05012	Parkinson disease	31/949	266/8135	0.5318	1	0.9915	UBE2G1/NDUFA12/ND4/ATF6/UBE2J1/XBP1/PARK7/LRRK2/NDUFS7/KIF5B/CYCS/PSMB7/NDUFB2/SLC39A9/PSMB4/HSPA5/SLC39A5/MAPT/MCU/MAPK8/SLC39A11/COX8C/UQCR10/COX7B/NDUFA11/COX6A1/TUBB1/UQCR11/MAPK9/ATP5PB/COX4I1	31
KEGG	hsa04380	Osteoclast differentiation	15/949	128/8135	0.5341	1	0.9915	SQSTM1/IFNAR2/TRAF6/SOCS3/NFATC2/PIK3R2/MAP2K7/PLCG2/STAT1/CAMK4/IFNAR1/MAPK8/AKT3/MAPK9/SIRPG	15
KEGG	hsa04979	Cholesterol metabolism	6/949	50/8135	0.5361	1	0.9915	SCARB1/NPC1/APOC2/LRPAP1/APOH/APOC3	6
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/949	24/8135	0.5426	1	0.9915	HS6ST1/HS3ST3B1/HS2ST1	3
KEGG	hsa04350	TGF-beta signaling pathway	11/949	94/8135	0.5439	1	0.9915	TGIF1/RGMA/ID4/ROCK1/CREBBP/ZFYVE16/RPS6KB1/NEO1/GREM2/CDKN2B/RGMB	11
KEGG	hsa04934	Cushing syndrome	18/949	155/8135	0.5462	1	0.9915	AIPL1/FZD3/USP8/CACNA1D/SCARB1/PDE8A/KMT2A/FZD1/CREB5/KCNK3/WNT5B/CDKN2B/CACNA1H/WNT7B/TCF7L2/RAP1A/FZD4/RASD1	18
KEGG	hsa04664	Fc epsilon RI signaling pathway	8/949	68/8135	0.5463	1	0.9915	NRAS/PLA2G4F/PIK3R2/MAP2K7/PLCG2/MAPK8/AKT3/MAPK9	8
KEGG	hsa04010	MAPK signaling pathway	34/949	294/8135	0.5501	1	0.9915	ERBB4/TAOK1/TRAF6/RPS6KA3/NRAS/FAS/CACNA1D/PLA2G4F/NLK/PDGFD/MAP3K6/PAK1/GNA12/INSR/GNG12/HSPA1L/ARAF/MAP2K7/MAPK8IP3/MRAS/MAP3K1/LAMTOR3/MAP3K13/RASGRF2/MAPT/EFNA5/PPM1A/CACNA1H/MAPK8/MAP3K8/AKT3/RAP1A/MAPK9/CDC42	34
KEGG	hsa00270	Cysteine and methionine metabolism	6/949	51/8135	0.5562	1	0.9915	BHMT2/MAT2B/DNMT3A/CBS/MTAP/GCLM	6
KEGG	hsa04725	Cholinergic synapse	13/949	113/8135	0.5657	1	0.9915	NRAS/CACNA1D/GNG12/CREB5/PIK3R2/GNGT2/GNG7/PIK3CG/CAMK4/AKT3/KCNQ4/CHRNB2/CHRM3	13
KEGG	hsa04721	Synaptic vesicle cycle	9/949	78/8135	0.567	1	0.9915	ATP6V1G3/CPLX2/AP2A1/SLC6A11/ATP6V0E1/ATP6V0B/SLC6A5/ATP6V1C1/ATP6V1G1	9
KEGG	hsa04810	Regulation of actin cytoskeleton	25/949	218/8135	0.569	1	0.9915	SPATA13/ITGB4/SSH2/DOCK1/BCAR1/NRAS/ROCK1/PDGFD/GNA13/PAK1/GNA12/PPP1R12C/ITGA2/GNG12/ARAF/ACTR3/WASF2/PIK3R2/MRAS/ARPC5L/GSN/PAK3/RDX/CDC42/CHRM3	25
KEGG	hsa04622	RIG-I-like receptor signaling pathway	8/949	70/8135	0.5806	1	0.9915	TRAF6/RIPK1/NFKBIB/AZI2/DDX58/MAP3K1/MAPK8/MAPK9	8
KEGG	hsa03015	mRNA surveillance pathway	11/949	97/8135	0.5876	1	0.9915	CPSF3/PAPOLG/GLE1/TARDBP/CPSF2/DAZAP1/PAPOLA/RBM8A/CSTF3/RNPS1/CPSF6	11
KEGG	hsa05020	Prion disease	31/949	273/8135	0.5936	1	0.9915	NDUFA12/ND4/BAD/CACNA1D/NDUFS7/KIF5B/HSPA1L/CSNK2A2/CREB5/CYCS/PSMB7/PIK3R2/NDUFB2/CSNK2A1/PSMB4/HSPA5/GRIN2B/MCU/MAPK8/C7/COX8C/UQCR10/COX7B/NDUFA11/EGR1/COX6A1/TUBB1/UQCR11/MAPK9/ATP5PB/COX4I1	31
KEGG	hsa04950	Maturity onset diabetes of the young	3/949	26/8135	0.5988	1	0.9915	FOXA3/HNF4A/PAX6	3
KEGG	hsa04936	Alcoholic liver disease	16/949	142/8135	0.5988	1	0.9915	IL17RA/TAB3/TRAF6/FAS/RIPK1/MLYCD/LPIN3/PRKAG3/MAP2K7/TRA2B/SCD5/MAPK8/AKT3/TCF7L2/PRKAB2/MAPK9	16
KEGG	hsa00450	Selenocompound metabolism	2/949	17/8135	0.6063	1	0.9915	SEPSECS/MARS2	2
KEGG	hsa05017	Spinocerebellar ataxia	16/949	143/8135	0.6105	1	0.9915	GRIA3/KCNC3/NRBF2/XBP1/ATP2A2/CYCS/PSMB7/PIK3R2/PSMB4/GRIN2B/MCU/MAPK8/AKT3/MAPK9/OMA1/AMBRA1	16
KEGG	hsa02010	ABC transporters	5/949	45/8135	0.6157	1	0.9915	TAP2/ABCB10/ABCC4/CFTR/ABCC3	5
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	4/949	36/8135	0.6188	1	0.9915	SIRT5/NNMT/NAMPT/ASPDH	4
KEGG	hsa04929	GnRH secretion	7/949	64/8135	0.6306	1	0.9915	CGA/NRAS/CACNA1D/PIK3R2/KISS1R/CACNA1H/AKT3	7
KEGG	hsa04210	Apoptosis	15/949	136/8135	0.6324	1	0.9915	NRAS/FAS/BAD/RIPK1/BIRC3/CYCS/PIK3R2/CASP2/DAB2IP/TNFRSF10A/MAPK8/AKT3/BID/MAPK9/XIAP	15
KEGG	hsa05165	Human papillomavirus infection	37/949	331/8135	0.6374	1	0.9915	ITGB4/HES7/IFNAR2/NRAS/FZD3/FAS/BAD/MDM2/ATP6V1G3/JAG1/ATP6V0E1/ATP6V0B/RHEB/FZD1/ITGA2/CRB3/LAMB4/CREBBP/CREB5/RPS6KB1/PIK3R2/VWF/PARD6G/STAT1/IFNAR1/NOTCH4/WNT5B/COL4A4/WNT7B/AKT3/TCF7L2/CCND2/FZD4/PTEN/ATP6V1C1/CDC42/ATP6V1G1	37
KEGG	hsa00061	Fatty acid biosynthesis	2/949	18/8135	0.6382	1	0.9915	ACSL5/OLAH	2
KEGG	hsa00511	Other glycan degradation	2/949	18/8135	0.6382	1	0.9915	FUCA1/NEU4	2
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	4/949	37/8135	0.641	1	0.9915	ATP1B3/INSR/PIK3R2/ATP1B4	4
KEGG	hsa05216	Thyroid cancer	4/949	37/8135	0.641	1	0.9915	NRAS/POLK/TCF7L2/TPM3	4
KEGG	hsa00514	Other types of O-glycan biosynthesis	5/949	47/8135	0.6549	1	0.9915	GALNT9/ST3GAL3/COLGALT1/GALNT10/B4GALT1	5
KEGG	hsa04973	Carbohydrate digestion and absorption	5/949	47/8135	0.6549	1	0.9915	CACNA1D/ATP1B3/PIK3R2/ATP1B4/AKT3	5
KEGG	hsa01230	Biosynthesis of amino acids	8/949	75/8135	0.6604	1	0.9915	PRPS2/PGK1/RPE/MAT2B/CBS/ALDH18A1/ACY1/ALDOA	8
KEGG	hsa05134	Legionellosis	6/949	57/8135	0.6675	1	0.9915	CR1/RAB1A/SAR1B/HSPA1L/ARF1/CYCS	6
KEGG	hsa01232	Nucleotide metabolism	9/949	85/8135	0.6725	1	0.9915	NT5C3A/CMPK1/RRM2B/NTPCR/CMPK2/ENTPD1/GMPS/AK3/AK4	9
KEGG	hsa04022	cGMP-PKG signaling pathway	18/949	167/8135	0.6769	1	0.9915	GATA4/BAD/CACNA1D/ROCK1/ATP1B3/GNA13/ATP2A2/GNA12/INSR/CREB5/NFATC2/SLC8A1/PIK3CG/MEF2D/ATP1B4/AKT3/KCNMB4/MEF2A	18
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/949	194/8135	0.6775	1	0.9915	STAT3/IFNAR2/NRAS/FAS/GNG12/CREBBP/NFATC2/CYCS/PIK3R2/MAP2K7/GNGT2/PLCG2/GNG7/STAT1/PIK3CG/IFNAR1/MAPK8/AKT3/TCF7L2/BID/MAPK9	21
KEGG	hsa04720	Long-term potentiation	7/949	67/8135	0.6791	1	0.9915	RPS6KA3/NRAS/ARAF/CREBBP/GRIN2B/CAMK4/RAP1A	7
KEGG	hsa04064	NF-kappa B signaling pathway	11/949	104/8135	0.6816	1	0.9915	TAB3/TRAF6/UBE2I/RIPK1/BIRC3/TNFSF13B/DDX58/CSNK2A2/CSNK2A1/PLCG2/XIAP	11
KEGG	hsa00240	Pyrimidine metabolism	6/949	58/8135	0.6843	1	0.9915	NT5C3A/CMPK1/RRM2B/UMPS/CMPK2/ENTPD1	6
KEGG	hsa00480	Glutathione metabolism	6/949	58/8135	0.6843	1	0.9915	GSR/RRM2B/TXNDC12/GGT7/CHAC2/GCLM	6
KEGG	hsa05225	Hepatocellular carcinoma	18/949	168/8135	0.6869	1	0.9915	NRAS/FZD3/BAD/ARID2/FZD1/ARAF/RPS6KB1/PIK3R2/PLCG2/LRP5/WNT5B/WNT7B/POLK/AKT3/TCF7L2/FZD4/PTEN/GAB1	18
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	24/949	222/8135	0.6875	1	0.9915	NRAS/B2M/HLA-DOA/CDC23/CRTC2/CREBBP/JAK3/CREB5/NFATC2/PIK3R2/MAP3K1/CDC26/ANAPC7/ETS1/CDKN2B/MAPK8/AKT3/CCND2/EGR1/ANAPC10/PTEN/MAPK9/TCF3/XIAP	24
KEGG	hsa00565	Ether lipid metabolism	5/949	49/8135	0.6915	1	0.9915	PAFAH1B2/SELENOI/PLA2G4F/ENPP6/LPCAT2	5
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	24/949	223/8135	0.6961	1	0.9915	NRAS/NDUFA12/ND4/BAD/NDUFS7/ARAF/PIK3R2/MAP2K7/NDUFB2/MAPK8/AKR1C2/COX8C/UQCR10/COX7B/AKT3/NDUFA11/COX6A1/UQCR11/PTEN/MAPK9/PRKD2/ATP5PB/SLC26A2/COX4I1	24
KEGG	hsa05033	Nicotine addiction	4/949	40/8135	0.7021	1	0.9915	GRIA3/GABRA4/GRIN2B/CHRNB2	4
KEGG	hsa05163	Human cytomegalovirus infection	24/949	225/8135	0.7127	1	0.9915	TAP2/STAT3/BCAR1/NRAS/FAS/MDM2/B2M/ROCK1/RIPK1/GNA13/RHEB/GNA12/GNG12/CREB5/NFATC2/CYCS/RPS6KB1/PIK3R2/GNGT2/IL6R/GNG7/AKT3/BID/PDIA3	24
KEGG	hsa05164	Influenza A	18/949	171/8135	0.7156	1	0.9915	IFNAR2/FAS/SOCS3/HLA-DOA/NFKBIB/KPNA6/DDX58/CREBBP/OAS2/CYCS/PIK3R2/KPNA5/STAT1/IFNAR1/TNFRSF10A/AKT3/BID/CALCOCO2	18
KEGG	hsa04730	Long-term depression	6/949	60/8135	0.716	1	0.9915	GRIA3/NRAS/PLA2G4F/GNA13/GNA12/ARAF	6
KEGG	hsa04630	JAK-STAT signaling pathway	17/949	162/8135	0.7166	1	0.9915	SOCS4/STAT3/IFNAR2/SOCS3/IL7R/OSM/CREBBP/JAK3/PIK3R2/IL6R/STAT1/IL20RB/IFNAR1/AKT3/CCND2/IFNLR1/IL21R	17
KEGG	hsa01240	Biosynthesis of cofactors	16/949	153/8135	0.7178	1	0.9915	SDR16C5/CMPK1/MAT2B/RDH13/UMPS/CMPK2/DLD/COQ5/TPK1/AK3/AK4/ASPDH/MMAB/COQ3/TDO2/GCLM	16
KEGG	hsa00052	Galactose metabolism	3/949	31/8135	0.7182	1	0.9915	PGM2/B4GALT1/GALM	3
KEGG	hsa03440	Homologous recombination	4/949	41/8135	0.7207	1	0.9915	BRCC3/RAD52/EME1/BARD1	4
KEGG	hsa04216	Ferroptosis	4/949	41/8135	0.7207	1	0.9915	ACSL5/PCBP2/ATG7/GCLM	4
KEGG	hsa04925	Aldosterone synthesis and secretion	10/949	98/8135	0.7211	1	0.9915	CACNA1D/SCARB1/ATP1B3/DAGLB/CREB5/KCNK3/CAMK4/CACNA1H/ATP1B4/PRKD2	10
KEGG	hsa04659	Th17 cell differentiation	11/949	108/8135	0.7291	1	0.9915	STAT3/HLA-DOA/NFKBIB/JAK3/NFATC2/RORC/IL6R/STAT1/MAPK8/IL21R/MAPK9	11
KEGG	hsa00380	Tryptophan metabolism	4/949	42/8135	0.7384	1	0.9915	ACMSD/DLD/DHTKD1/TDO2	4
KEGG	hsa04136	Autophagy - other	3/949	32/8135	0.7385	1	0.9915	ATG4C/ATG7/ATG16L1	3
KEGG	hsa00230	Purine metabolism	13/949	128/8135	0.744	1	0.9915	PRPS2/PGM2/ADPRM/PDE6D/NUDT5/RRM2B/PDE8A/NTPCR/PDE4A/ENTPD1/GMPS/AK3/AK4	13
KEGG	hsa00220	Arginine biosynthesis	2/949	22/8135	0.7454	1	0.9915	GLS/ACY1	2
KEGG	hsa04024	cAMP signaling pathway	23/949	221/8135	0.7529	1	0.9915	GRIA3/CGA/BAD/CACNA1D/ROCK1/ATP1B3/ATP2A2/PDE4A/PAK1/PTCH1/ABCC4/CREBBP/CREB5/PIK3R2/CFTR/GRIN2B/CAMK4/EDN1/MAPK8/ATP1B4/AKT3/RAP1A/MAPK9	23
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	22/949	212/8135	0.7539	1	0.9915	STAT3/KPNA4/AIPL1/RPS6KA3/NRAS/BAD/CACNA1D/DLL3/JAG1/KPNA6/CREB5/RPS6KB1/PIK3R2/KPNA5/PAQR8/MIRLET7D/BCL6/DLL4/DLL1/AKT3/CHRNB2/XIAP	22
KEGG	hsa05415	Diabetic cardiomyopathy	21/949	203/8135	0.7551	1	0.9915	GSR/NDUFA12/ND4/ATP2A2/NDUFS7/INSR/PIK3R2/NDUFB2/MAPK8/COX8C/UQCR10/COX7B/AKT3/NDUFA11/COX6A1/UQCR11/PTEN/MAPK9/ATP5PB/ACE/COX4I1	21
KEGG	hsa05226	Gastric cancer	15/949	149/8135	0.7666	1	0.9915	NRAS/FZD3/FZD1/ARAF/RPS6KB1/PIK3R2/LRP5/WNT5B/CDKN2B/WNT7B/POLK/AKT3/TCF7L2/FZD4/GAB1	15
KEGG	hsa04962	Vasopressin-regulated water reabsorption	4/949	44/8135	0.7713	1	0.9915	DYNC1LI1/CREB5/DCTN4/DYNC1I2	4
KEGG	hsa05016	Huntington disease	32/949	306/8135	0.7742	1	0.9915	GRIA3/NDUFA12/ND4/DNAH14/NRBF2/AP2A1/NDUFS7/KIF5B/TAF4B/CREBBP/CREB5/CYCS/PSMB7/MAP2K7/NDUFB2/PSMB4/GRIN2B/MAPK8/DCTN4/COX8C/UQCR10/COX7B/NDUFA11/COX6A1/TUBB1/UQCR11/MAPK9/ATP5PB/TFAM/AMBRA1/COX4I1/DNAH12	32
KEGG	hsa03020	RNA polymerase	3/949	34/8135	0.7755	1	0.9915	POLR1B/ZNRD1/POLR3A	3
KEGG	hsa04142	Lysosome	13/949	132/8135	0.7823	1	0.9915	AP3M1/MFSD8/AP1S2/SLC11A1/HGSNAT/AP4E1/NPC1/ATP6V0B/LAMP2/FUCA1/NAPSA/NCOA7/AP4S1	13
KEGG	hsa04657	IL-17 signaling pathway	9/949	94/8135	0.7829	1	0.9915	IL17RA/TAB3/TRAF6/IL17C/IL17RE/USP25/MAPK15/MAPK8/MAPK9	9
KEGG	hsa04927	Cortisol synthesis and secretion	6/949	65/8135	0.7855	1	0.9915	CACNA1D/SCARB1/PDE8A/CREB5/KCNK3/CACNA1H	6
KEGG	hsa03320	PPAR signaling pathway	7/949	75/8135	0.7874	1	0.9915	ME3/ACSL5/FADS2/SLC27A5/PLIN5/SCD5/APOC3	7
KEGG	hsa04918	Thyroid hormone synthesis	7/949	75/8135	0.7874	1	0.9915	GSR/CGA/ATP1B3/DUOXA2/CREB5/HSPA5/ATP1B4	7
KEGG	hsa04977	Vitamin digestion and absorption	2/949	24/8135	0.788	1	0.9915	SCARB1/SLC19A1	2
KEGG	hsa04923	Regulation of lipolysis in adipocytes	5/949	56/8135	0.7981	1	0.9915	CGA/INSR/ABHD5/PIK3R2/AKT3	5
KEGG	hsa05220	Chronic myeloid leukemia	7/949	76/8135	0.7988	1	0.9915	NRAS/BAD/MDM2/ARAF/PIK3R2/POLK/AKT3	7
KEGG	hsa03050	Proteasome	4/949	46/8135	0.8009	1	0.9915	POMP/PSMB7/PSMB4/PSMF1	4
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	10/949	106/8135	0.8063	1	0.9915	HBEGF/GNA13/PDE4A/GNA12/ARAF/CREB5/LRP5/MEF2D/EGR1/MEF2A	10
KEGG	hsa00592	alpha-Linolenic acid metabolism	2/949	25/8135	0.8069	1	0.9915	PLA2G4F/FADS2	2
KEGG	hsa00512	Mucin type O-glycan biosynthesis	3/949	36/8135	0.8081	1	0.9915	GALNT9/GCNT1/GALNT10	3
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/949	77/8135	0.8097	1	0.9915	ITGB4/DSC2/CACNA1D/ATP2A2/ITGA2/SLC8A1/TCF7L2	7
KEGG	hsa04062	Chemokine signaling pathway	19/949	192/8135	0.811	1	0.9915	STAT3/BCAR1/GRK3/NRAS/BAD/ROCK1/NFKBIB/PAK1/GNG12/JAK3/PIK3R2/GNGT2/PLCG2/GNG7/STAT1/PIK3CG/AKT3/RAP1A/CDC42	19
KEGG	hsa04110	Cell cycle	12/949	126/8135	0.8129	1	0.9915	MDM2/CDC23/YWHAG/CREBBP/MAD2L2/CDC26/ANAPC7/CDKN2B/SMC1A/ORC2/CCND2/ANAPC10	12
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/949	26/8135	0.8242	1	0.9915	PIGN/PIGU	2
KEGG	hsa04727	GABAergic synapse	8/949	89/8135	0.8303	1	0.9915	CACNA1D/SLC6A11/GNG12/GABRA4/GLS/GNGT2/GNG7/SLC38A5	8
KEGG	hsa04723	Retrograde endocannabinoid signaling	14/949	148/8135	0.8346	1	0.9915	GRIA3/NDUFA12/ND4/CACNA1D/DAGLB/NDUFS7/GNG12/GABRA4/NDUFB2/GNGT2/GNG7/MAPK8/NDUFA11/MAPK9	14
KEGG	hsa04926	Relaxin signaling pathway	12/949	129/8135	0.8368	1	0.9915	NRAS/GNG12/CREB5/PIK3R2/MAP2K7/GNGT2/GNG7/EDN1/COL4A4/MAPK8/AKT3/MAPK9	12
KEGG	hsa05417	Lipid and atherosclerosis	21/949	215/8135	0.8381	1	0.9915	ERO1A/STAT3/TRAF6/NRAS/FAS/BAD/ATF6/XBP1/HSPA1L/NFATC2/CYCS/PIK3R2/MAP2K7/HSPA5/TNFRSF10A/MAPK8/AKT3/RAP1A/BID/MAPK9/CDC42	21
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/949	27/8135	0.8401	1	0.9915	ST3GAL3/B4GALT1	2
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	2/949	27/8135	0.8401	1	0.9915	FADS2/SCD5	2
KEGG	hsa05230	Central carbon metabolism in cancer	6/949	70/8135	0.8413	1	0.9915	NRAS/PDK1/GLS/PIK3R2/AKT3/PTEN	6
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/949	15/8135	0.8447	1	0.9915	GBGT1	1
KEGG	hsa04916	Melanogenesis	9/949	101/8135	0.8481	1	0.9915	NRAS/FZD3/FZD1/CREBBP/WNT5B/EDN1/WNT7B/TCF7L2/FZD4	9
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	12/949	131/8135	0.8514	1	0.9915	IFNAR2/NRAS/FAS/HCST/PAK1/ARAF/NFATC2/PIK3R2/PLCG2/IFNAR1/TNFRSF10A/BID	12
KEGG	hsa05152	Tuberculosis	17/949	180/8135	0.8557	1	0.9915	CR1/TRAF6/BAD/PLK3/HLA-DOA/TLR9/CLEC4E/ATP6V0B/LAMP2/CREBBP/CYCS/STAT1/CEBPG/MAPK8/AKT3/BID/MAPK9	17
KEGG	hsa05142	Chagas disease	9/949	102/8135	0.856	1	0.9915	TRAF6/FAS/TLR9/PIK3R2/MAPK8/AKT3/MAPK9/GNA14/ACE	9
KEGG	hsa04728	Dopaminergic synapse	12/949	132/8135	0.8583	1	0.9915	GRIA3/CACNA1D/KIF5B/GNG12/CREB5/GNGT2/GNG7/GRIN2B/CLOCK/MAPK8/AKT3/MAPK9	12
KEGG	hsa04913	Ovarian steroidogenesis	4/949	51/8135	0.8614	1	0.9915	CGA/SCARB1/PLA2G4F/INSR	4
KEGG	hsa00260	Glycine, serine and threonine metabolism	3/949	40/8135	0.8614	1	0.9915	CBS/DLD/SARDH	3
KEGG	hsa04145	Phagosome	14/949	152/8135	0.8614	1	0.9915	TAP2/DYNC1LI1/SCARB1/ATP6V1G3/HLA-DOA/ATP6V0E1/ATP6V0B/LAMP2/ITGA2/SEC61A1/DYNC1I2/TUBB1/ATP6V1C1/ATP6V1G1	14
KEGG	hsa00430	Taurine and hypotaurine metabolism	1/949	16/8135	0.8628	1	0.9915	GGT7	1
KEGG	hsa04015	Rap1 signaling pathway	20/949	210/8135	0.8632	1	0.9915	FARP2/BCAR1/NRAS/PDGFD/RALA/RAPGEF6/INSR/PIK3R2/PARD6G/MRAS/GRIN2B/EFNA5/RAPGEF1/RASSF5/AKT3/RAP1A/DOCK4/PRKD2/SIPA1L2/CDC42	20
KEGG	hsa04611	Platelet activation	11/949	124/8135	0.8707	1	0.9915	PLA2G4F/ROCK1/GNA13/ITGA2/PIK3R2/VWF/PLCG2/P2RY12/PIK3CG/AKT3/RAP1A	11
KEGG	hsa04623	Cytosolic DNA-sensing pathway	5/949	63/8135	0.8734	1	0.9915	RIPK3/RIPK1/NFKBIB/DDX58/POLR3A	5
KEGG	hsa00120	Primary bile acid biosynthesis	1/949	17/8135	0.8789	1	0.9915	SLC27A5	1
KEGG	hsa00910	Nitrogen metabolism	1/949	17/8135	0.8789	1	0.9915	CA12	1
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/949	53/8135	0.8808	1	0.9915	ATP1B3/AP2A1/SLC8A1/ATP1B4	4
KEGG	hsa04911	Insulin secretion	7/949	86/8135	0.8883	1	0.9915	CACNA1D/ATP1B3/FFAR1/CREB5/ATP1B4/KCNMB4/CHRM3	7
KEGG	hsa05321	Inflammatory bowel disease	5/949	65/8135	0.8899	1	0.9915	STAT3/HLA-DOA/RORC/STAT1/IL21R	5
KEGG	hsa04390	Hippo signaling pathway	14/949	157/8135	0.89	1	0.9915	FZD3/BIRC3/YWHAG/FZD1/PARD6G/WNT5B/MOB1B/WNT7B/CSNK1E/TCF7L2/CCND2/TEAD2/FZD4/NKD2	14
KEGG	hsa04922	Glucagon signaling pathway	9/949	107/8135	0.8907	1	0.9915	PPP4R3B/CRTC2/PPP4R3A/SIK1/CREBBP/CREB5/PRKAG3/AKT3/PRKAB2	9
KEGG	hsa04971	Gastric acid secretion	6/949	76/8135	0.892	1	0.9915	ATP1B3/KCNJ16/CFTR/ATP1B4/CHRM3/KCNK10	6
KEGG	hsa04713	Circadian entrainment	8/949	97/8135	0.8924	1	0.9915	GRIA3/CACNA1D/GNG12/GNGT2/GNG7/GRIN2B/CACNA1H/RASD1	8
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	5/949	66/8135	0.8975	1	0.9915	WARS2/QRSL1/SEPSECS/PARS2/MARS2	5
KEGG	hsa00640	Propanoate metabolism	2/949	32/8135	0.9018	1	0.9915	MLYCD/DLD	2
KEGG	hsa00010	Glycolysis / Gluconeogenesis	5/949	67/8135	0.9046	1	0.9915	PGM2/PGK1/DLD/ALDOA/GALM	5
KEGG	hsa00531	Glycosaminoglycan degradation	1/949	19/8135	0.9055	1	0.9915	HGSNAT	1
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/949	19/8135	0.9055	1	0.9915	ACY1	1
KEGG	hsa04612	Antigen processing and presentation	6/949	78/8135	0.9055	1	0.9915	TAP2/B2M/HLA-DOA/HSPA1L/HSPA5/PDIA3	6
KEGG	hsa04976	Bile secretion	7/949	89/8135	0.9076	1	0.9915	SCARB1/ATP1B3/SLC27A5/ABCC4/CFTR/ABCC3/ATP1B4	7
KEGG	hsa04114	Oocyte meiosis	11/949	131/8135	0.9104	1	0.9915	RPS6KA3/CPEB3/CDC23/YWHAG/MAD2L2/CDC26/ANAPC7/SMC1A/PLCZ1/ANAPC10/FBXO5	11
KEGG	hsa00051	Fructose and mannose metabolism	2/949	33/8135	0.9111	1	0.9915	PFKFB4/ALDOA	2
KEGG	hsa03410	Base excision repair	2/949	33/8135	0.9111	1	0.9915	POLE4/HMGB1	2
KEGG	hsa00100	Steroid biosynthesis	1/949	20/8135	0.9166	1	0.9915	CYP2R1	1
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/949	20/8135	0.9166	1	0.9915	CHST13	1
KEGG	hsa00670	One carbon pool by folate	1/949	20/8135	0.9166	1	0.9915	MTHFR	1
KEGG	hsa05031	Amphetamine addiction	5/949	69/8135	0.9175	1	0.9915	GRIA3/CACNA1D/CREB5/GRIN2B/CAMK4	5
KEGG	hsa05032	Morphine addiction	7/949	91/8135	0.9187	1	0.9915	GRK3/PDE8A/PDE4A/GNG12/GABRA4/GNGT2/GNG7	7
KEGG	hsa00040	Pentose and glucuronate interconversions	2/949	34/8135	0.9195	1	0.9915	DHDH/RPE	2
KEGG	hsa04972	Pancreatic secretion	8/949	102/8135	0.9206	1	0.9915	ATP1B3/ATP2A2/RAB3D/RAB27B/CFTR/ATP1B4/RAP1A/CHRM3	8
KEGG	hsa05203	Viral carcinogenesis	18/949	204/8135	0.9224	1	0.9915	STAT3/NRAS/BAD/MDM2/GTF2A1/YWHAG/CREBBP/JAK3/CREB5/PIK3R2/REL/USP7/CDKN2B/HDAC10/GSN/CCND2/GTF2H3/CDC42	18
KEGG	hsa00620	Pyruvate metabolism	3/949	47/8135	0.924	1	0.9915	LDHD/ME3/DLD	3
KEGG	hsa03420	Nucleotide excision repair	3/949	47/8135	0.924	1	0.9915	POLE4/GTF2H3/ERCC4	3
KEGG	hsa04670	Leukocyte transendothelial migration	9/949	114/8135	0.9274	1	0.9915	JAM3/BCAR1/ROCK1/CLDN23/PIK3R2/PLCG2/RASSF5/RAP1A/CDC42	9
KEGG	hsa04724	Glutamatergic synapse	9/949	114/8135	0.9274	1	0.9915	GRIA3/GRK3/CACNA1D/PLA2G4F/GNG12/GLS/GNGT2/GNG7/GRIN2B	9
KEGG	hsa04662	B cell receptor signaling pathway	6/949	82/8135	0.9283	1	0.9915	NRAS/NFKBIB/NFATC2/PIK3R2/PLCG2/AKT3	6
KEGG	hsa05323	Rheumatoid arthritis	7/949	93/8135	0.9287	1	0.9915	ATP6V1G3/HLA-DOA/ATP6V0E1/TNFSF13B/ATP6V0B/ATP6V1C1/ATP6V1G1	7
KEGG	hsa00500	Starch and sucrose metabolism	2/949	36/8135	0.9342	1	0.9915	PGM2/PGM2L1	2
KEGG	hsa03030	DNA replication	2/949	36/8135	0.9342	1	0.9915	POLE4/RNASEH2B	2
KEGG	hsa00340	Histidine metabolism	1/949	22/8135	0.935	1	0.9915	HNMT	1
KEGG	hsa04151	PI3K-Akt signaling pathway	33/949	354/8135	0.9353	1	0.9915	ITGB4/EIF4E2/ERBB4/IFNAR2/NRAS/BAD/MDM2/CRTC2/PDGFD/YWHAG/RHEB/IL7R/INSR/ITGA2/THEM4/GNG12/LAMB4/OSM/JAK3/CREB5/RPS6KB1/PIK3R2/VWF/GNGT2/IL6R/GNG7/PIK3CG/IFNAR1/EFNA5/COL4A4/AKT3/CCND2/PTEN	33
KEGG	hsa04672	Intestinal immune network for IgA production	3/949	49/8135	0.9364	1	0.9915	HLA-DOA/TNFSF13B/AICDA	3
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	2/949	37/8135	0.9406	1	0.9915	GLS/RIMKLB	2
KEGG	hsa05143	African trypanosomiasis	2/949	37/8135	0.9406	1	0.9915	FAS/TLR9	2
KEGG	hsa05414	Dilated cardiomyopathy	7/949	96/8135	0.9417	1	0.9915	ITGB4/CACNA1D/ATP2A2/ITGA2/TPM2/SLC8A1/TPM3	7
KEGG	hsa04614	Renin-angiotensin system	1/949	23/8135	0.9426	1	0.9915	ACE	1
KEGG	hsa05330	Allograft rejection	2/949	38/8135	0.9464	1	0.9915	FAS/HLA-DOA	2
KEGG	hsa00330	Arginine and proline metabolism	3/949	51/8135	0.9469	1	0.9915	PRODH2/ALDH18A1/L3HYPDH	3
KEGG	hsa05202	Transcriptional misregulation in cancer	16/949	193/8135	0.9499	1	0.9915	GRIA3/MDM2/CDK14/BIRC3/EWSR1/KMT2A/NSD2/REL/BCL6/CCNT2/POLK/CCND2/BCL11B/JMJD1C/ETV5/TCF3	16
KEGG	hsa04512	ECM-receptor interaction	6/949	88/8135	0.9533	1	0.9915	ITGB4/ITGA2/LAMB4/VWF/COL4A4/FREM2	6
KEGG	hsa05140	Leishmaniasis	5/949	77/8135	0.955	1	0.9915	CR1/TRAF6/HLA-DOA/NFKBIB/STAT1	5
KEGG	hsa05320	Autoimmune thyroid disease	3/949	53/8135	0.9558	1	0.9915	CGA/FAS/HLA-DOA	3
KEGG	hsa04270	Vascular smooth muscle contraction	10/949	134/8135	0.9591	1	0.9915	CACNA1D/PLA2G4F/ROCK1/GNA13/GNA12/PPP1R12C/ARAF/EDN1/KCNMB4/CALD1	10
KEGG	hsa04020	Calcium signaling pathway	20/949	240/8135	0.9636	1	0.9915	ERBB4/CACNA1D/ITPKB/P2RX7/PDGFD/ATP2A2/STIM2/PLCD4/PLCG2/SLC8A1/CAMK4/MCOLN3/MCU/CACNA1H/P2RX2/CYSLTR1/PLCZ1/PLCD3/GNA14/CHRM3	20
KEGG	hsa04974	Protein digestion and absorption	7/949	103/8135	0.9642	1	0.9915	SLC36A4/COL26A1/COL8A1/ATP1B3/SLC8A1/COL4A4/ATP1B4	7
KEGG	hsa00983	Drug metabolism - other enzymes	5/949	80/8135	0.9645	1	0.9915	CMPK1/RRM2B/TPMT/UMPS/GMPS	5
KEGG	hsa05332	Graft-versus-host disease	2/949	42/8135	0.9646	1	0.9915	FAS/HLA-DOA	2
KEGG	hsa00830	Retinol metabolism	4/949	68/8135	0.9647	1	0.9915	SDR16C5/RDH13/DHRS9/CYP3A5	4
KEGG	hsa00062	Fatty acid elongation	1/949	27/8135	0.9651	1	0.9915	THEM4	1
KEGG	hsa00860	Porphyrin metabolism	2/949	43/8135	0.9681	1	0.9915	BLVRA/MMAB	2
KEGG	hsa04940	Type I diabetes mellitus	2/949	43/8135	0.9681	1	0.9915	FAS/HLA-DOA	2
KEGG	hsa01212	Fatty acid metabolism	3/949	57/8135	0.9695	1	0.9915	ACSL5/FADS2/SCD5	3
KEGG	hsa05418	Fluid shear stress and atherosclerosis	10/949	139/8135	0.9702	1	0.9915	SQSTM1/KLF2/PIK3R2/MAP2K7/EDN1/MIR10A/MAPK8/AKT3/MAPK9/MEF2A	10
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	11/949	150/8135	0.9704	1	0.9915	CACNA1D/ATP1B3/ATP2A2/TPM2/CREB5/SLC8A1/PIK3CG/KCNE1/ATP1B4/AKT3/TPM3	11
KEGG	hsa00591	Linoleic acid metabolism	1/949	29/8135	0.9728	1	0.9915	PLA2G4F	1
KEGG	hsa00020	Citrate cycle (TCA cycle)	1/949	30/8135	0.976	1	0.9915	DLD	1
KEGG	hsa00053	Ascorbate and aldarate metabolism	1/949	30/8135	0.976	1	0.9915	MIOX	1
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	1/949	30/8135	0.976	1	0.9915	DLD	1
KEGG	hsa04921	Oxytocin signaling pathway	11/949	154/8135	0.977	1	0.9915	NRAS/CACNA1D/PLA2G4F/ROCK1/PPP1R12C/PRKAG3/NFATC2/EEF2/PIK3CG/CAMK4/PRKAB2	11
KEGG	hsa04978	Mineral absorption	3/949	60/8135	0.977	1	0.9915	ATP1B3/SLC8A1/ATP1B4	3
KEGG	hsa05416	Viral myocarditis	3/949	60/8135	0.977	1	0.9915	HLA-DOA/CYCS/BID	3
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	6/949	98/8135	0.9781	1	0.9915	PLA2G4F/PIK3R2/TRPV2/PLCG2/MAPK8/MAPK9	6
KEGG	hsa00410	beta-Alanine metabolism	1/949	31/8135	0.9788	1	0.9915	MLYCD	1
KEGG	hsa05310	Asthma	1/949	31/8135	0.9788	1	0.9915	HLA-DOA	1
KEGG	hsa00140	Steroid hormone biosynthesis	3/949	61/8135	0.9791	1	0.9915	SRD5A3/AKR1C2/CYP3A5	3
KEGG	hsa04640	Hematopoietic cell lineage	6/949	99/8135	0.9798	1	0.9915	CR1/CD9/HLA-DOA/IL7R/ITGA2/IL6R	6
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/949	100/8135	0.9813	1	0.9915	ACKR3/IL6R/TNFRSF10D/IL20RB/TNFRSF10A/IL34	6
KEGG	hsa05030	Cocaine addiction	2/949	49/8135	0.9831	1	0.9915	CREB5/GRIN2B	2
KEGG	hsa05144	Malaria	2/949	50/8135	0.9848	1	0.9915	CR1/TLR9	2
KEGG	hsa04726	Serotonergic synapse	7/949	115/8135	0.9853	1	0.9915	NRAS/CACNA1D/PLA2G4F/GNG12/ARAF/GNGT2/GNG7	7
KEGG	hsa00350	Tyrosine metabolism	1/949	36/8135	0.9886	1	0.9915	HGD	1
KEGG	hsa04924	Renin secretion	3/949	69/8135	0.9904	1	0.9915	CACNA1D/EDN1/ACE	3
KEGG	hsa04610	Complement and coagulation cascades	4/949	85/8135	0.9923	1	0.9915	CR1/MASP1/VWF/C7	4
KEGG	hsa04742	Taste transduction	4/949	86/8135	0.993	1	0.9915	GABRA4/SCN3A/P2RX2/CHRM3	4
KEGG	hsa04915	Estrogen signaling pathway	8/949	138/8135	0.9937	1	0.9915	NRAS/HBEGF/HSPA1L/CREB5/PIK3R2/KRT27/FKBP5/AKT3	8
KEGG	hsa01200	Carbon metabolism	6/949	115/8135	0.9945	1	0.9915	PRPS2/PGK1/RPE/ME3/DLD/ALDOA	6
KEGG	hsa00071	Fatty acid degradation	1/949	43/8135	0.9952	1	0.9915	ACSL5	1
KEGG	hsa04975	Fat digestion and absorption	1/949	43/8135	0.9952	1	0.9915	SCARB1	1
KEGG	hsa05133	Pertussis	3/949	76/8135	0.9952	1	0.9915	TRAF6/MAPK8/MAPK9	3
KEGG	hsa00280	Valine, leucine and isoleucine degradation	1/949	48/8135	0.9975	1	0.9915	DLD	1
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	2/949	69/8135	0.9981	1	0.9915	AKR1C2/CYP3A5	2
KEGG	hsa04060	Cytokine-cytokine receptor interaction	20/949	295/8135	0.9984	1	0.9915	IL17RA/IFNAR2/FAS/IL17C/IL17RE/TNFSF13B/IL7R/OSM/GDF11/ACKR3/IL6R/TNFRSF10D/IL20RB/IFNAR1/TNFRSF10A/IL34/TNFRSF19/ACVRL1/IFNLR1/IL21R	20
KEGG	hsa05146	Amoebiasis	4/949	102/8135	0.9985	1	0.9915	LAMB4/PIK3R2/COL4A4/GNA14	4
KEGG	hsa04540	Gap junction	3/949	88/8135	0.9986	1	0.9915	NRAS/PDGFD/TUBB1	3
KEGG	hsa05206	MicroRNAs in cancer	21/949	310/8135	0.9987	1	0.9915	STAT3/NRAS/FZD3/MDM2/UBE2I/ROCK1/DNMT3A/MARCKS/CREBBP/IGF2BP1/GLS/PIK3R2/PLCG2/MIR146A/MIRLET7D/NOTCH4/EFNA5/MIR10A/CCND2/RDX/PTEN	21
KEGG	hsa04970	Salivary secretion	3/949	93/8135	0.9992	1	0.9915	ATP1B3/ATP1B4/CHRM3	3
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/949	78/8135	0.9993	1	0.9915	DHDH/CYP3A5	2
KEGG	hsa05150	Staphylococcus aureus infection	3/949	96/8135	0.9994	1	0.9915	HLA-DOA/MASP1/KRT27	3
KEGG	hsa00590	Arachidonic acid metabolism	1/949	61/8135	0.9995	1	0.9915	PLA2G4F	1
KEGG	hsa05034	Alcoholism	9/949	187/8135	0.9997	1	0.9915	NRAS/GNG12/ARAF/CREB5/GNGT2/GNG7/GRIN2B/CAMK4/HDAC10	9
KEGG	hsa04613	Neutrophil extracellular trap formation	9/949	190/8135	0.9997	1	0.9915	CR1/TLR8/ATG7/PIK3R2/VWF/PLCG2/HMGB1/HDAC10/AKT3	9
KEGG	hsa00982	Drug metabolism - cytochrome P450	1/949	72/8135	0.9999	1	0.9915	CYP3A5	1
KEGG	hsa05322	Systemic lupus erythematosus	3/949	136/8135	1	1	0.9915	HLA-DOA/GRIN2B/C7	3
KEGG	hsa04080	Neuroactive ligand-receptor interaction	18/949	353/8135	1	1	0.9915	GRIA3/CGA/P2RX7/LTB4R/PTGDR/NPW/GABRA4/GRIN2B/S1PR2/CHRNA10/GLRB/KISS1R/EDN1/P2RX2/CYSLTR1/CHRNB2/UCN2/CHRM3	18
KEGG	hsa04740	Olfactory transduction	7/949	440/8135	1	1	0.9915	GRK3/GNG7/SLC8A1/OR6B1/OR51M1/OR51B5/SLC24A4	7