ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 72/1364 223/8135 6.228e-09 2.074e-06 1.514e-06 GSTA4/NFKBIA/EPHX1/MAP3K5/PRKD2/COX7A1/MAPK3/NDUFC1/SLC25A4/ATP5MC1/NDUFS4/NDUFA13/HGF/SDHC/SOS1/EPHX2/NDUFA4L2/UQCR10/EGFR/NDUFA4/BAD/GSTM4/NDUFB4/NDUFA8/EGF/NQO1/MGST3/PIK3CB/PRKD3/CYC1/CHUK/CAT/PLD1/COX6C/COX8A/SDHD/COX6A1/MAPK11/NDUFB6/NFKB1/NDUFA6/NDUFB2/GSTM5/NDUFB11/NDUFB7/ATP5MC3/ATP5F1D/KRAS/COX5B/GSTM3/NDUFA10/VEGFA/AKR1C3/UQCRQ/ACP1/ATP5PF/NDUFA3/SOD1/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/VDAC3/HIF1A/AHR/PIK3CD/ATP5F1B/AKR1C4/NRAS/ATP5MC2/RAF1 72 KEGG hsa05166 Human T-cell leukemia virus 1 infection 67/1364 222/8135 3.781e-07 6.295e-05 4.597e-05 NFKBIA/IL15RA/HLA-C/MAPK3/IL15/SLC25A4/ATM/SMAD3/HLA-G/IL2RG/CHEK2/HLA-F/CCNA2/HLA-A/ATR/CDKN2C/HLA-DQB1/CREB3/CHEK1/ITGAL/PTTG1/HLA-E/HLA-B/CDK4/EGR1/JAK1/PIK3CB/BUB1B/CD40/CHUK/ADCY1/TRRAP/TSPO/NFKB1/MAP3K3/RELB/CD3E/EP300/LCK/KRAS/MYC/CCNB2/IL2RB/CD3D/STAT5A/CDC20/ATF2/IL6/HLA-DOB/PPP3CA/KAT5/ELK4/CREB1/VDAC3/KAT2B/HLA-DQA1/PIK3CD/ETS2/ATF4/PTTG2/CDKN1A/NRAS/CRTC3/PRKACB/TLN2/E2F3/CD3G 67 KEGG hsa04660 T cell receptor signaling pathway 36/1364 104/8135 6.883e-06 0.0005946 0.0004342 NFKBIA/RASGRP1/MAPK3/MALT1/SOS1/PTPRC/ITK/CD8A/NCK2/CTLA4/GSK3B/CDK4/PIK3CB/MAP3K8/CHUK/MAPK11/ZAP70/CBLB/CD28/NFKB1/PAK2/CD3E/LCK/IFNG/KRAS/CD3D/CD247/PPP3CA/PRKCQ/BCL10/LAT/PIK3CD/LCP2/NRAS/RAF1/CD3G 36 KEGG hsa05020 Prion disease 74/1364 273/8135 8.389e-06 0.0005946 0.0004342 NOTCH1/C7/CCL5/COX7A1/MAPK3/NDUFC1/SLC25A4/ATP5MC1/NDUFS4/NDUFA13/SDHC/TUBB2B/NDUFA4L2/UQCR10/NDUFA4/BAD/CREB3/NDUFB4/PRNP/NDUFA8/GSK3B/EGR1/PIK3CB/ITPR2/CYC1/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/COX6A1/MAPK11/CSNK2B/NDUFB6/HSPA6/PSMC3/NDUFA6/NDUFB2/NDUFB11/NDUFB7/APAF1/ATP5MC3/ATP5F1D/PSMB5/TUBA4A/PSMB6/COX5B/NDUFA10/RAC2/ATF2/IL6/UQCRQ/KIF5C/ATP5PF/NDUFA3/SOD1/PPP3CA/NDUFB8/ATP5PD/NDUFS7/NDUFS3/RYR2/NDUFA2/CREB1/VDAC3/CACNA1D/PSMD8/PIK3CD/ATP5F1B/ATF4/PRKACB/ATP5MC2/TUBB2A 74 KEGG hsa05014 Amyotrophic lateral sclerosis 93/1364 364/8135 8.929e-06 0.0005946 0.0004342 TNFRSF1B/SETX/MAP3K5/COX7A1/DNAL4/NUP58/TBK1/NDUFC1/SIGMAR1/ATP5MC1/NDUFS4/NDUFA13/NUP153/SDHC/NXF3/TUBB2B/NDUFA4L2/NUP160/HNRNPA2B1/SPG11/UQCR10/NDUFA4/BAD/NDUFB4/TPR/DCTN6/PFN2/GPX3/SEC13/NDUFA8/PINK1/DCTN3/ATF6/CYC1/RANBP2/CAT/NUP50/GRIA2/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/PRKN/COX6A1/MAPK11/GPX1/ATG2B/OPTN/NDUFB6/NXF1/PSMC3/NDUFA6/NUP43/NDUFB2/NDUFB11/NDUFB7/APAF1/ATP5MC3/ATP5F1D/PSMB5/TUBA4A/PSMB6/COX5B/DCTN2/NDUFA10/DAXX/ANG/NUP210/NUP98/UQCRQ/KIF5C/ATG13/TARDBP/ATP5PF/NDUFA3/SOD1/PPP3CA/NDUFB8/ATP5PD/NDUFS7/NDC1/NDUFS3/NDUFA2/UBQLN4/PSMD8/HNRNPA1/ATP5F1B/ATF4/ATP5MC2/TUBB2A/TANK 93 KEGG hsa04658 Th1 and Th2 cell differentiation 32/1364 92/8135 1.971e-05 0.0009687 0.0007074 NFKBIA/NOTCH1/JAK2/STAT1/MAPK3/IL2RG/IL4R/HLA-DQB1/RBPJ/RUNX3/TYK2/MAML1/JAK1/CHUK/MAPK11/ZAP70/NFKB1/CD3E/STAT4/LCK/IFNG/IL2RB/CD3D/STAT5A/CD247/JAG2/HLA-DOB/PPP3CA/PRKCQ/LAT/HLA-DQA1/CD3G 32 KEGG hsa04010 MAPK signaling pathway 77/1364 294/8135 2.111e-05 0.0009687 0.0007074 DUSP5/CDC25B/MAP3K5/RASGRP1/MAPK3/PGF/ANGPT1/FAS/HGF/PRKCB/SOS1/INSR/MAP3K11/DUSP6/ANGPT2/EGFR/NTRK2/KIT/EFNA5/EGF/PTPN7/RASGRP3/ERBB2/FGF5/MAP3K8/MAPK7/NTF3/FGF20/CHUK/PLA2G4C/TAOK3/ARRB1/MAPK11/EREG/NTRK1/PPM1B/RAP1B/HSPA6/GNG12/MAP4K1/NFKB1/MAP3K3/FGF18/MAP4K4/RELB/HSPB1/PAK2/NLK/PDGFB/IRAK4/KRAS/MYC/BDNF/KDR/IGF1/DAXX/VEGFA/RAC2/RPS6KA3/TAOK1/ATF2/NGFR/MKNK2/DUSP2/PPP3CA/MAPKAPK2/ELK4/CACNB2/CACNA1D/CACNA2D3/FLNA/FGFR4/ATF4/NRAS/PRKACB/RAF1/RPS6KA1 77 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 31/1364 89/8135 2.564e-05 0.0009687 0.0007074 NFKBIA/JAK2/STAT1/RASGRP1/MAPK3/EGFR/EGF/JAK1/PIK3CB/CHUK/MAPK11/CSNK2B/ZAP70/CD28/NFKB1/MAP3K3/CD3E/LCK/IFNG/KRAS/CD3D/CD247/PPP3CA/PRKCQ/BATF/HIF1A/LAT/PIK3CD/NRAS/RAF1/CD3G 31 KEGG hsa05169 Epstein-Barr virus infection 57/1364 202/8135 2.618e-05 0.0009687 0.0007074 TNFAIP3/NFKBIA/TAP1/CXCL10/HLA-C/STAT1/PLCG2/TBK1/FAS/HLA-G/HLA-F/CCNA2/HLA-A/TRAF5/HLA-DQB1/ITGAL/HLA-E/RBPJ/HLA-B/RUNX3/CDK4/TYK2/JAK1/PIK3CB/CD44/CD40/CHUK/CASP9/IRF3/PSMC2/DDB2/TAPBP/MAPK11/PSMC3/NFKB1/RELB/CD3E/APAF1/IRAK4/HDAC1/MYC/CD3D/CD247/TRAF3/IL6/HLA-DOB/CD19/TAP2/CIR1/CD58/HES1/PSMD8/HLA-DQA1/PIK3CD/CDKN1A/E2F3/CD3G 57 KEGG hsa04932 Non-alcoholic fatty liver disease 46/1364 155/8135 4.017e-05 0.001271 0.0009283 CEBPA/MAP3K5/COX7A1/NDUFC1/FAS/NDUFS4/NDUFA13/SDHC/INSR/MAP3K11/NDUFA4L2/UQCR10/NDUFA4/PRKAG1/NDUFB4/NDUFA8/PRKAB1/GSK3B/RXRA/PIK3CB/CYC1/PPARG/COX6C/COX8A/SDHD/COX6A1/MAPK11/NDUFB6/NFKB1/NDUFA6/NDUFB2/NDUFB11/NDUFB7/COX5B/NDUFA10/IL6R/IL6/UQCRQ/NDUFA3/NDUFB8/NDUFS7/NDUFS3/NDUFA2/PIK3CD/ATF4/CXCL8 46 KEGG hsa05012 Parkinson disease 70/1364 266/8135 4.22e-05 0.001271 0.0009283 MAP3K5/SLC18A2/COX7A1/NDUFC1/SNCA/SLC25A4/ATP5MC1/NDUFS4/NDUFA13/SDHC/UCHL1/TUBB2B/NDUFA4L2/UQCR10/UBE2J1/NDUFA4/NDUFB4/NDUFA8/PINK1/TH/ITPR2/ATF6/CYC1/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/PRKN/COX6A1/NDUFB6/TXN2/PSMC3/NDUFA6/TRAP1/UBB/NDUFB2/SNCAIP/SLC39A8/NDUFB11/NDUFB7/APAF1/ATP5MC3/ATP5F1D/PSMB5/TUBA4A/PSMB6/COX5B/NDUFA10/DAXX/UQCRQ/KIF5C/SLC39A14/ATP5PF/NDUFA3/SOD1/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/VDAC3/PSMD8/CAMK2B/ATP5F1B/ATF4/PRKACB/ATP5MC2/TUBB2A 70 KEGG hsa04659 Th17 cell differentiation 35/1364 108/8135 4.581e-05 0.001271 0.0009283 NFKBIA/JAK2/STAT1/IL21R/MAPK3/IL27RA/SMAD3/IL2RG/RORA/IL4R/HLA-DQB1/TYK2/RXRA/JAK1/CHUK/MAPK11/ZAP70/NFKB1/CD3E/LCK/IFNG/IL2RB/CD3D/STAT5A/CD247/IL6R/IL6/HLA-DOB/PPP3CA/PRKCQ/HIF1A/AHR/LAT/HLA-DQA1/CD3G 35 KEGG hsa04066 HIF-1 signaling pathway 35/1364 109/8135 5.68e-05 0.001325 0.0009676 TFRC/MAPK3/PLCG2/ANGPT1/PRKCB/INSR/ANGPT2/EGFR/SERPINE1/ENO2/ELOB/EGF/ERBB2/PIK3CB/PFKFB3/PFKM/NFKB1/NOS3/EP300/IFNG/CUL2/EGLN3/IGF1/VEGFA/IL6R/IL6/PDK1/MKNK2/PDHB/HIF1A/ALDOC/PIK3CD/CAMK2B/TIMP1/CDKN1A 35 KEGG hsa05170 Human immunodeficiency virus 1 infection 58/1364 212/8135 5.907e-05 0.001325 0.0009676 NFKBIA/TAP1/TNFRSF1B/HLA-C/MAPK3/PLCG2/LIMK2/TBK1/SKP1/ATM/FAS/HLA-G/PRKCB/APOBEC3C/HLA-F/HLA-A/TRAF5/ATR/BAD/CHEK1/CCR5/SAMHD1/ELOB/GNG3/HLA-E/AP1B1/HLA-B/AP1G2/PIK3CB/ITPR2/CHUK/CASP9/IRF3/TAPBP/MAPK11/CXCR4/GNG12/NFKB1/PAK2/CD3E/IRAK4/KRAS/CCNB2/AP1S1/CD3D/RAC2/CD247/CCNB1/PPP3CA/TAP2/GNB2/APOBEC3B/PIK3CD/WEE1/AP1G1/NRAS/RAF1/CD3G 58 KEGG hsa05415 Diabetic cardiomyopathy 56/1364 203/8135 6.151e-05 0.001325 0.0009676 PDK2/COX7A1/ATP2A3/NDUFC1/SLC25A4/SMAD3/ATP5MC1/NDUFS4/NDUFA13/PRKCB/SDHC/CMA1/INSR/MPC2/NDUFA4L2/UQCR10/NDUFA4/NDUFB4/NDUFA8/GSK3B/PIK3CB/CYC1/AGT/COX6C/COX8A/SDHD/COX6A1/MAPK11/NDUFB6/NFKB1/NDUFA6/NOS3/NDUFB2/NDUFB11/NDUFB7/ATP5MC3/ATP5F1D/COX5B/NDUFA10/RAC2/UQCRQ/ATP5PF/NDUFA3/NDUFB8/ATP5PD/NDUFS7/NDUFS3/RYR2/NDUFA2/VDAC3/PDHB/PIK3CD/CAMK2B/ATP5F1B/COL3A1/ATP5MC2 56 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 54/1364 194/8135 6.367e-05 0.001325 0.0009676 NFKBIA/JAK2/HLA-C/STAT1/MAPK3/PLCG2/TBK1/FAS/HLA-G/MICB/HLA-F/HLA-A/ANGPT2/TCF7/CCR5/GNG3/HLA-E/HLA-B/GSK3B/CDK4/TYK2/JAK1/PIK3CB/ITPR2/CXCL2/LEF1/CHUK/CASP9/IRF3/MAPK11/PIK3R5/GNG12/NFKB1/UBB/EP300/PDGFB/KRAS/MYC/VEGFA/TRAF3/IL6/PPP3CA/MAPKAPK2/GNB2/CREB1/CXCL3/HIF1A/PIK3CD/TCF7L2/CXCL8/CDKN1A/NRAS/RAF1/E2F3 54 KEGG hsa04722 Neurotrophin signaling pathway 37/1364 119/8135 7.634e-05 0.001495 0.001092 NFKBIA/BEX3/IRAK3/MAP3K5/MAPK3/PLCG2/RIPK2/SH2B2/SOS1/BAD/NTRK2/GSK3B/PIK3CB/MAPK7/NTF3/MAPK11/PRDM4/NTRK1/RAP1B/NFKB1/MAP3K3/IRAK4/KRAS/BDNF/MAGED1/RPS6KA3/NGFR/MAPKAPK2/SH2B3/SORT1/PIK3CD/CAMK2B/ATF4/NRAS/MATK/RAF1/RPS6KA1 37 KEGG hsa04919 Thyroid hormone signaling pathway 37/1364 121/8135 0.0001126 0.002081 0.00152 DIO3/NOTCH1/ATP1B1/STAT1/ATP2A3/MAPK3/PLCG2/MED13/NCOA3/PRKCB/SLC16A2/BAD/NOTCH4/GSK3B/RXRA/MED1/MED13L/PIK3CB/BMP4/CASP9/PFKM/EP300/HDAC1/KRAS/MYC/PLCD1/DIO2/PLCE1/MED24/MED17/NCOR1/KAT2B/HIF1A/PIK3CD/NRAS/PRKACB/RAF1 37 KEGG hsa04064 NF-kappa B signaling pathway 33/1364 104/8135 0.0001188 0.002081 0.00152 TNFAIP3/NFKBIA/BIRC3/UBE2I/PLCG2/ATM/TRAF1/MALT1/PRKCB/TRAF5/CFLAR/BIRC2/BCL2A1/TNFRSF11A/CXCL2/CD40/CHUK/CSNK2B/ZAP70/NFKB1/CARD14/RELB/CYLD/CCL13/IRAK4/LCK/TRAF3/PRKCQ/BCL10/CXCL3/TNFSF14/LAT/CXCL8 33 KEGG hsa05010 Alzheimer disease 92/1364 384/8135 0.0001377 0.002294 0.001675 WNT5B/MAP3K5/ADAM17/COX7A1/ATP2A3/MAPK3/NDUFC1/SNCA/SLC25A4/FAS/ATP5MC1/NDUFS4/NDUFA13/SDHC/HSD17B10/INSR/TUBB2B/NDUFA4L2/UQCR10/NDUFA4/BAD/APOE/NDUFB4/IDE/NDUFA8/GSK3B/PIK3CB/ITPR2/ATF6/CYC1/WNT11/CHUK/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/COX6A1/ATG2B/FZD3/LPL/LRP5/CSNK2B/NDUFB6/PSMC3/NFKB1/NDUFA6/NDUFB2/SLC39A8/NDUFB11/NDUFB7/APAF1/ATP5MC3/PSENEN/ATP5F1D/KRAS/PSMB5/TUBA4A/PSMB6/DKK4/COX5B/NDUFA10/CSNK1A1/FZD6/IL6/UQCRQ/KIF5C/ATG13/SLC39A14/ATP5PF/NDUFA3/PPP3CA/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/VDAC3/FRAT1/FZD2/CACNA1D/PSMD8/APH1B/PIK3CD/ATP5F1B/RTN3/ATF4/NRAS/ATP5MC2/RAF1/TUBB2A 92 KEGG hsa05016 Huntington disease 76/1364 306/8135 0.000159 0.002521 0.001841 MAP3K5/COX7A1/DNAL4/NDUFC1/SLC25A4/ATP5MC1/NDUFS4/NDUFA13/SDHC/POLR2I/POLR2J/POLR2E/TUBB2B/NDUFA4L2/POLR2L/UQCR10/NDUFA4/CREB3/NDUFB4/POLR2F/DCTN6/GPX3/NDUFA8/DCTN3/AP2M1/CYC1/PPARG/POLR2C/GRIA2/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/COX6A1/GPX1/ATG2B/NDUFB6/PSMC3/NDUFA6/NDUFB2/EP300/NDUFB11/NDUFB7/APAF1/ATP5MC3/HDAC1/POLR2G/ATP5F1D/PSMB5/TUBA4A/PSMB6/COX5B/BDNF/DCTN2/NDUFA10/UQCRQ/KIF5C/ATG13/ATP5PF/NDUFA3/SOD1/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/CREB1/VDAC3/PSMD8/ATP5F1B/RCOR1/ATP5MC2/TUBB2A/POLR2B 76 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 109/1364 476/8135 0.0002335 0.003444 0.002515 TNFRSF1B/WNT5B/MAP3K5/COX7A1/ATP2A3/DNAL4/MAPK3/TBK1/NDUFC1/SNCA/SLC25A4/FAS/SIGMAR1/ATP5MC1/NDUFS4/NDUFA13/PRKCB/SDHC/HSD17B10/UCHL1/TUBB2B/NDUFA4L2/SPG11/UQCR10/UBE2J1/NDUFA4/BAD/NDUFB4/PRNP/DCTN6/GPX3/NDUFA8/PINK1/GSK3B/DCTN3/ITPR2/ATF6/CYC1/WNT11/CAT/GRIA2/COX6C/CASP9/COX8A/PSMC2/SDHD/TUBB6/PRKN/COX6A1/MAPK11/GPX1/ATG2B/FZD3/OPTN/LRP5/CSNK2B/NDUFB6/PSMC3/NFKB1/NDUFA6/TRAP1/UBB/NDUFB2/SNCAIP/NDUFB11/NDUFB7/APAF1/ATP5MC3/ATP5F1D/KRAS/PSMB5/TUBA4A/PSMB6/DKK4/COX5B/BDNF/DCTN2/NDUFA10/DAXX/CSNK1A1/FZD6/IL6/UQCRQ/KIF5C/ATG13/TARDBP/ATP5PF/NDUFA3/SOD1/PPP3CA/NDUFB8/ATP5PD/NDUFS7/NDUFS3/RYR2/NDUFA2/VDAC3/FRAT1/FZD2/CACNA1D/PSMD8/CAMK2B/ATP5F1B/ATF4/NRAS/ATP5MC2/RAF1/TUBB2A/TANK 109 KEGG hsa00190 Oxidative phosphorylation 39/1364 134/8135 0.0002378 0.003444 0.002515 COX7A1/NDUFC1/ATP5MC1/NDUFS4/NDUFA13/ATP6V0D1/SDHC/ATP6V1F/NDUFA4L2/UQCR10/NDUFA4/NDUFB4/NDUFA8/CYC1/COX6C/COX8A/SDHD/COX6A1/NDUFB6/TCIRG1/NDUFA6/NDUFB2/NDUFB11/NDUFB7/ATP5MC3/ATP5F1D/COX5B/NDUFA10/UQCRQ/ATP5PF/ATP6V0E2/NDUFA3/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/ATP5F1B/ATP5MC2 39 KEGG hsa04210 Apoptosis 39/1364 136/8135 0.0003322 0.0046 0.003359 NFKBIA/CSF2RB/BIRC3/PARP3/MAP3K5/MAPK3/CTSW/ATM/TRAF1/FAS/CFLAR/BIRC2/BCL2A1/BAD/CTSF/PIK3CB/ITPR2/PRF1/LMNB1/PARP4/GZMB/CHUK/CTSO/CASP9/NTRK1/NFKB1/APAF1/KRAS/TUBA4A/DAXX/DFFB/BIRC5/MCL1/PIK3CD/IL3RA/ATF4/NRAS/RAF1/AIFM1 39 KEGG hsa05221 Acute myeloid leukemia 23/1364 67/8135 0.000352 0.0046 0.003359 CEBPA/MAPK3/SOS1/CCNA2/DUSP6/BCL2A1/TCF7/BAD/KIT/PIM1/PIK3CB/LEF1/CHUK/PIM2/NFKB1/KRAS/MYC/STAT5A/PML/PIK3CD/TCF7L2/NRAS/RAF1 23 KEGG hsa04370 VEGF signaling pathway 21/1364 59/8135 0.0003592 0.0046 0.003359 SPHK1/MAPK3/PLCG2/PRKCB/BAD/SH2D2A/PIK3CB/PLA2G4C/CASP9/MAPK11/NOS3/HSPB1/KRAS/KDR/VEGFA/RAC2/PPP3CA/MAPKAPK2/PIK3CD/NRAS/RAF1 21 KEGG hsa05212 Pancreatic cancer 25/1364 76/8135 0.0004184 0.005161 0.003768 STAT1/MAPK3/SMAD3/EGFR/BAD/RALA/EGF/CDK4/ERBB2/JAK1/PIK3CB/CHUK/PLD1/CASP9/DDB2/NFKB1/KRAS/RALGDS/VEGFA/RAC2/BRCA2/PIK3CD/CDKN1A/RAF1/E2F3 25 KEGG hsa04014 Ras signaling pathway 59/1364 232/8135 0.000441 0.005245 0.00383 RGL1/RASGRP1/MAPK3/PLCG2/TBK1/PGF/ANGPT1/HGF/PRKCB/SOS1/PLA2G2D/INSR/ANGPT2/EGFR/BAD/RALA/REL/NTRK2/KIT/GNG3/RASAL2/EFNA5/EGF/RASGRP3/FGF5/PIK3CB/NTF3/FGF20/CHUK/PLA2G4C/PLD1/NTRK1/ZAP70/RAP1B/GNG12/NFKB1/PLA1A/FGF18/PAK2/EXOC2/PDGFB/KRAS/RALGDS/BDNF/SHOC2/KDR/IGF1/VEGFA/RAC2/PLCE1/NGFR/GNB2/LAT/PIK3CD/FGFR4/ETS2/NRAS/PRKACB/RAF1 59 KEGG hsa05330 Allograft rejection 15/1364 38/8135 0.000711 0.007892 0.005763 HLA-C/FAS/HLA-G/HLA-F/HLA-A/HLA-DQB1/HLA-E/HLA-B/PRF1/CD40/GZMB/CD28/IFNG/HLA-DOB/HLA-DQA1 15 KEGG hsa05340 Primary immunodeficiency 15/1364 38/8135 0.000711 0.007892 0.005763 TAP1/DCLRE1C/RFX5/IL7R/IL2RG/PTPRC/CD8A/ADA/CD40/ZAP70/CD3E/LCK/CD3D/CD19/TAP2 15 KEGG hsa05202 Transcriptional misregulation in cancer 50/1364 193/8135 0.0007502 0.008059 0.005885 SIX1/HOXA11/NSD2/NUPR1/CEBPA/BIRC3/HOXA10/ATM/TRAF1/CCNA2/DUSP6/BIRC2/BCL2A1/CDKN2C/SS18L1/REL/ELANE/HPGD/RXRA/BCL11B/CD40/GZMB/PPARG/DEFA6/DDB2/NTRK1/CCNT2/ETV6/NFKB1/MLF1/ITGB7/HDAC1/MYC/IL2RB/IGF1/FUT8/IL6/NGFR/ETV7/NCOR1/PML/ELK4/SPINT1/TSPAN7/SMAD1/CXCL8/CDKN1A/CEBPB/JMJD1C/DEFA5 50 KEGG hsa04714 Thermogenesis 58/1364 232/8135 0.000777 0.008086 0.005905 MAP3K5/COX7A1/NDUFC1/NDUFAF3/ATP5MC1/NDUFS4/NDUFA13/SDHC/SOS1/NDUFA4L2/UQCR10/NDUFA4/CREB3/PRKAG1/NDUFB4/SMARCD3/ACSL5/NDUFA8/PRKAB1/KDM3A/CYC1/PPARG/ADCY1/COX6C/COX8A/SDHD/COX6A1/MAPK11/ARID1A/NDUFB6/NDUFA6/NDUFB2/NDUFB11/NDUFB7/ATP5MC3/ATP5F1D/KRAS/COX5B/NDUFA10/RPS6KA3/COA3/ATF2/UQCRQ/ATP5PF/NDUFA3/MLST8/NDUFB8/ATP5PD/NDUFS7/NDUFS3/NDUFA2/CREB1/ATP5F1B/NRAS/PRKACB/ATP5MC2/SMARCD2/RPS6KA1 58 KEGG hsa04218 Cellular senescence 42/1364 156/8135 0.000848 0.008557 0.006248 HLA-C/MAPK3/NBN/SLC25A4/ATM/SMAD3/HLA-G/CHEK2/HLA-F/CCNA2/HLA-A/ATR/MRE11/SERPINE1/CHEK1/HLA-E/HLA-B/CDK4/PIK3CB/ITPR2/MAPK11/NFKB1/RAD50/FOXM1/KRAS/MYC/CCNB2/ZFP36L2/CCNB1/RBL2/IL6/PPP3CA/MAPKAPK2/VDAC3/RAD1/CACNA1D/PIK3CD/CXCL8/CDKN1A/NRAS/RAF1/E2F3 42 KEGG hsa05215 Prostate cancer 29/1364 97/8135 0.0008978 0.008794 0.006421 NFKBIA/AR/MAPK3/SOS1/TCF7/EGFR/BAD/CREB3/EGF/GSK3B/ERBB2/PIK3CB/LEF1/CHUK/CASP9/NFKB1/EP300/PDGFB/KRAS/IGF1/CREB1/SPINT1/PIK3CD/TCF7L2/ATF4/CDKN1A/NRAS/RAF1/E2F3 29 KEGG hsa04151 PI3K-Akt signaling pathway 82/1364 354/8135 0.000954 0.009076 0.006628 JAK2/DDIT4/LAMC3/MAPK3/PGF/THBS4/ANGPT1/IL7R/HGF/IL2RG/SOS1/IL4R/INSR/G6PC3/ANGPT2/ITGA5/EGFR/BAD/CREB3/NTRK2/KIT/GNG3/EFNA5/EGF/GSK3B/CDK4/ERBB2/FGF5/RXRA/JAK1/PIK3CB/NTF3/FGF20/CHUK/F2R/MAGI2/CASP9/CHAD/EREG/NTRK1/PIK3R5/LAMA5/GNG12/NFKB1/FGF18/NOS3/ITGB7/PDGFB/YWHAH/KRAS/MYC/BDNF/COMP/KDR/THBS2/IL2RB/IGF1/VEGFA/IL6R/PCK2/RBL2/ATF2/IL6/COL6A3/NGFR/MLST8/CD19/GNB2/CREB1/GHR/PCK1/ITGA4/MCL1/PIK3CD/FGFR4/IL3RA/ATF4/CDKN1A/NRAS/LPAR2/RAF1/EPOR 82 KEGG hsa04940 Type I diabetes mellitus 16/1364 43/8135 0.00102 0.009437 0.006891 HLA-C/FAS/HLA-G/HLA-F/HLA-A/HLA-DQB1/HLA-E/HLA-B/PRF1/GZMB/CD28/IFNG/PTPRN2/HLA-DOB/CPE/HLA-DQA1 16 KEGG hsa05223 Non-small cell lung cancer 23/1364 72/8135 0.001107 0.009965 0.007277 MAPK3/PLCG2/HGF/PRKCB/SOS1/EGFR/BAD/EGF/CDK4/ERBB2/RXRA/PIK3CB/FHIT/CASP9/DDB2/KRAS/STAT5A/KIF5C/PIK3CD/CDKN1A/NRAS/RAF1/E2F3 23 KEGG hsa04668 TNF signaling pathway 32/1364 112/8135 0.001176 0.0103 0.007522 TNFAIP3/NFKBIA/TNFRSF1B/CXCL10/BIRC3/IRF1/MAP3K5/CCL5/MAPK3/IL15/TRAF1/FAS/TRAF5/CFLAR/BIRC2/CREB3/PIK3CB/MAP3K8/CXCL2/CHUK/SELE/MAPK11/NFKB1/NOD2/TRAF3/ATF2/IL6/CREB1/CXCL3/PIK3CD/ATF4/CEBPB 32 KEGG hsa04146 Peroxisome 25/1364 82/8135 0.001458 0.01213 0.00886 ECI2/ACOX2/PMVK/PEX19/EPHX2/PEX10/DECR2/DDO/PXMP2/ACSL5/PHYH/ECH1/HMGCL/CAT/PEX7/PEX11A/PEX2/MPV17/FAR2/SOD1/SCP2/ACOT8/PEX12/PXMP4/PEX14 25 KEGG hsa04662 B cell receptor signaling pathway 25/1364 82/8135 0.001458 0.01213 0.00886 NFKBIA/MAPK3/PLCG2/DAPP1/LILRB2/MALT1/PRKCB/SOS1/LILRA2/GSK3B/RASGRP3/CD72/PIK3CB/CHUK/NFKB1/CD81/KRAS/RAC2/PPP3CA/CD19/BCL10/FCGR2B/PIK3CD/NRAS/RAF1 25 KEGG hsa04142 Lysosome 36/1364 132/8135 0.001508 0.01224 0.008941 FUCA1/LGMN/GUSB/CTSW/LAMP3/PLA2G15/ATP6V0D1/CTSA/GNPTAB/ENTPD4/DMXL2/AP1B1/AP1G2/CTSF/ASAH1/NAGLU/HEXA/CTSO/TCIRG1/SLC11A1/ABCA2/CTSG/GM2A/AP1S1/CD63/AP4M1/AP4S1/DNASE2/ARSB/NEU1/LIPA/SORT1/NPC1/MCOLN1/AP1G1/GAA 36 KEGG hsa03440 Homologous recombination 15/1364 41/8135 0.001773 0.01373 0.01003 TOPBP1/NBN/ATM/MRE11/POLD2/BARD1/RPA1/POLD4/RPA3/BABAM2/RAD50/BRCA2/RAD51C/RAD51B/BABAM1 15 KEGG hsa05219 Bladder cancer 15/1364 41/8135 0.001773 0.01373 0.01003 MAPK3/EGFR/EGF/CDK4/ERBB2/TYMP/HBEGF/KRAS/MYC/VEGFA/CXCL8/CDKN1A/NRAS/RAF1/E2F3 15 KEGG hsa05163 Human cytomegalovirus infection 55/1364 225/8135 0.001823 0.0138 0.01008 NFKBIA/TAP1/HLA-C/CCL5/MAPK3/TBK1/FAS/HLA-G/PRKCB/SOS1/HLA-F/HLA-A/TRAF5/EGFR/ROCK1/CREB3/CCR5/GNG3/HLA-E/HLA-B/GSK3B/CDK4/JAK1/PIK3CB/ITPR2/CHUK/PTGER4/ADCY1/CASP9/IRF3/TAPBP/MAPK11/CXCR4/GNG12/NFKB1/KRAS/MYC/VEGFA/RAC2/IL6R/ATF2/IL6/PPP3CA/TAP2/GNB2/CREB1/CXCR2/PIK3CD/ATF4/CXCL8/CDKN1A/NRAS/PRKACB/RAF1/E2F3 55 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 24/1364 79/8135 0.001897 0.01403 0.01025 JAK2/MAPK3/PLCG2/HGF/PRKCB/SOS1/EGFR/BAD/EGF/GSK3B/ERBB2/JAK1/PIK3CB/PDGFB/KRAS/KDR/IGF1/VEGFA/IL6R/IL6/AXL/PIK3CD/NRAS/RAF1 24 KEGG hsa05213 Endometrial cancer 19/1364 58/8135 0.002101 0.01521 0.0111 MAPK3/SOS1/TCF7/EGFR/BAD/EGF/GSK3B/ERBB2/PIK3CB/LEF1/CASP9/DDB2/KRAS/MYC/PIK3CD/TCF7L2/CDKN1A/NRAS/RAF1 19 KEGG hsa05332 Graft-versus-host disease 15/1364 42/8135 0.002338 0.01656 0.01209 HLA-C/FAS/HLA-G/HLA-F/HLA-A/HLA-DQB1/HLA-E/HLA-B/PRF1/GZMB/CD28/IFNG/IL6/HLA-DOB/HLA-DQA1 15 KEGG hsa04110 Cell cycle 34/1364 126/8135 0.002436 0.0169 0.01234 CDC25B/CDC7/SKP1/ATM/SMAD3/CHEK2/CCNA2/ATR/CDKN2C/CHEK1/PTTG1/DBF4/ORC3/GSK3B/CDK4/BUB1B/ORC6/CDC14A/EP300/YWHAH/CDKN1C/HDAC1/MYC/CCNB2/CDC20/CCNB1/RBL2/CCNH/SMC1A/RAD21/WEE1/PTTG2/CDKN1A/E2F3 34 KEGG hsa04068 FoxO signaling pathway 35/1364 131/8135 0.002543 0.01728 0.01262 MAPK3/GABARAPL1/ATM/SMAD3/GABARAPL2/IL7R/SOS1/INSR/G6PC3/EGFR/PRKAG1/EGF/PRKAB1/PIK3CB/PLK2/S1PR1/CHUK/CAT/MAPK11/EP300/NLK/KRAS/CCNB2/IGF1/PCK2/CCNB1/RBL2/HOMER2/IL6/HOMER3/PCK1/PIK3CD/CDKN1A/NRAS/RAF1 35 KEGG hsa05224 Breast cancer 38/1364 147/8135 0.003202 0.02133 0.01557 NOTCH1/WNT5B/MAPK3/NCOA3/SOS1/TCF7/EGFR/NOTCH4/KIT/EGF/GSK3B/CDK4/ERBB2/FGF5/PIK3CB/LEF1/WNT11/FGF20/DDB2/FZD3/LRP5/FGF18/KRAS/MYC/IGF1/CSNK1A1/BRCA2/JAG2/FZD6/FRAT1/FZD2/HES1/PIK3CD/TCF7L2/CDKN1A/NRAS/RAF1/E2F3 38 KEGG hsa04630 JAK-STAT signaling pathway 41/1364 162/8135 0.003418 0.02189 0.01598 IL11RA/CSF2RB/IL15RA/JAK2/STAT1/SOCS6/IL21R/IL27RA/IL15/IL7R/IL2RG/SOS1/IL4R/SOCS1/EGFR/PIM1/EGF/TYK2/JAK1/PIK3CB/CTF1/PTPN2/EP300/STAT4/PDGFB/IFNG/MYC/IL2RB/STAT5A/IL6R/IL6/IL13RA2/SOCS5/GHR/MCL1/PIK3CD/IL3RA/CDKN1A/RAF1/CISH/EPOR 41 KEGG hsa05161 Hepatitis B 41/1364 162/8135 0.003418 0.02189 0.01598 NFKBIA/JAK2/STAT1/MAPK3/TBK1/FAS/SMAD3/PRKCB/SOS1/CCNA2/BAD/CREB3/TYK2/JAK1/PIK3CB/CHUK/CASP9/IRF3/DDB2/MAPK11/NFKB1/EP300/STAT4/APAF1/IRAK4/KRAS/MYC/STAT5A/TRAF3/ATF2/IL6/CREB1/VDAC3/BIRC5/PIK3CD/ATF4/CXCL8/CDKN1A/NRAS/RAF1/E2F3 41 KEGG hsa00120 Primary bile acid biosynthesis 8/1364 17/8135 0.003569 0.02242 0.01637 CH25H/ACOX2/SLC27A5/CYP7B1/CYP46A1/SCP2/ACOT8/AKR1C4 8 KEGG hsa04062 Chemokine signaling pathway 47/1364 192/8135 0.003669 0.02263 0.01652 CXCL9/NFKBIA/CXCL10/JAK2/STAT1/CCL5/MAPK3/PLCG2/CXCL13/CCL18/CXCL11/PRKCB/SOS1/ITK/ROCK1/BAD/CX3CR1/CCR5/GNG3/GSK3B/PIK3CB/FGR/CXCL2/CHUK/ADCY1/ARRB1/PIK3R5/RAP1B/CXCR4/GNG12/CCL8/NFKB1/CCL13/KRAS/RAC2/XCL1/GNB2/CXCL3/CCR7/CCL7/CXCR2/GRK6/PIK3CD/CXCL8/NRAS/PRKACB/RAF1 47 KEGG hsa00280 Valine, leucine and isoleucine degradation 16/1364 48/8135 0.003784 0.02291 0.01673 IVD/ALDH7A1/ECHS1/BCKDHB/HSD17B10/PCCB/HMGCL/HADH/OXCT1/DLD/ACAT1/ALDH9A1/ALDH6A1/ALDH3A2/ACAA2/HMGCS2 16 KEGG hsa05165 Human papillomavirus infection 74/1364 331/8135 0.004387 0.02579 0.01883 NOTCH1/TUBG2/HLA-C/WNT5B/STAT1/IRF1/LAMC3/MAPK3/TBK1/THBS4/ATM/FAS/HLA-G/ATP6V0D1/SOS1/TADA3/HLA-F/CCNA2/HLA-A/ATR/ATP6V1F/TCF7/ITGA5/EGFR/BAD/CREB3/NOTCH4/HLA-E/RBPJ/EGF/HLA-B/GSK3B/CDK4/TYK2/MAML1/JAK1/PIK3CB/WNT11/CHUK/PTGER4/IRF3/RFNG/CHAD/FZD3/TCIRG1/LAMA5/NFKB1/EP300/PRKCI/ITGB7/HDAC1/KRAS/COMP/THBS2/VEGFA/CSNK1A1/TRAF3/FZD6/RBL2/COL6A3/ATP6V0E2/UBE3A/LLGL2/CREB1/UBR4/FZD2/HES1/ITGA4/PIK3CD/TCF7L2/CDKN1A/NRAS/PRKACB/RAF1 74 KEGG hsa05132 Salmonella infection 58/1364 249/8135 0.004433 0.02579 0.01883 NFKBIA/ACTR3B/BIRC3/MAPK3/ARPC1A/RIPK2/SKP1/PTPRC/BIRC2/TUBB2B/ACTR3/TCF7/RALA/DCTN6/PFN2/CASP4/DYNC1H1/EXOC7/DCTN3/PIK3CB/STX10/DYNLRB1/LEF1/ARL8B/VPS16/PIK3C2B/CHUK/CYFIP2/TUBB6/MAPK11/ABI1/TXN2/NFKB1/PIK3C2G/EXOC2/KPNA3/ACTR2/IRAK4/MYC/TUBA4A/DCTN2/ACBD3/KPNA1/DYNC1I1/IL6/KIF5C/TLR5/NAIP/GSDMD/FLNA/PIK3CD/TCF7L2/CXCL8/ARPC5L/RAF1/TUBB2A/PIK3C2A/CSE1L 58 KEGG hsa04621 NOD-like receptor signaling pathway 45/1364 184/8135 0.004493 0.02579 0.01883 TNFAIP3/NFKBIA/GBP1/AIM2/GBP2/STAT1/BIRC3/CCL5/MAPK3/TRIP6/TBK1/RIPK2/GABARAPL1/GABARAPL2/TRAF5/BIRC2/CARD8/ERBIN/NLRP1/CASP4/TYK2/JAK1/ITPR2/CXCL2/CHUK/IRF3/DEFA6/MAPK11/TXN2/NFKB1/NOD2/IFI16/IRAK4/NAMPT/TRAF3/IL6/NAIP/GSDMD/CXCL3/VDAC3/TRPV2/CXCL8/DEFA5/CAMP/TANK 45 KEGG hsa04015 Rap1 signaling pathway 50/1364 210/8135 0.005039 0.02844 0.02077 PRKD2/MAPK3/PGF/ANGPT1/HGF/PRKCB/INSR/ANGPT2/EGFR/ITGAL/RALA/KIT/PFN2/EFNA5/EGF/RASGRP3/FGF5/PIK3CB/PRKD3/KRIT1/FGF20/F2R/ADCY1/MAGI2/FYB1/RAPGEF6/MAPK11/RAP1B/SIPA1L1/FGF18/ARAP3/PRKCI/PDGFB/SIPA1L3/KRAS/RALGDS/KDR/IGF1/VEGFA/RAC2/PLCE1/NGFR/LAT/PIK3CD/FGFR4/LCP2/NRAS/LPAR2/RAF1/TLN2 50 KEGG hsa05216 Thyroid cancer 13/1364 37/8135 0.005271 0.02926 0.02136 MAPK3/TCF7/TPR/RXRA/LEF1/PPARG/DDB2/NTRK1/KRAS/MYC/TCF7L2/CDKN1A/NRAS 13 KEGG hsa04012 ErbB signaling pathway 24/1364 85/8135 0.005426 0.02935 0.02143 MAPK3/PLCG2/BTC/PRKCB/SOS1/EGFR/BAD/NCK2/EGF/GSK3B/ERBB2/PIK3CB/EREG/CBLB/HBEGF/PAK2/KRAS/MYC/STAT5A/PIK3CD/CAMK2B/CDKN1A/NRAS/RAF1 24 KEGG hsa05164 Influenza A 42/1364 171/8135 0.005465 0.02935 0.02143 NFKBIA/TPSAB1/TPSB2/CXCL10/JAK2/STAT1/CCL5/ADAR/MAPK3/TBK1/SLC25A4/FAS/PRKCB/NXF3/HLA-DQB1/KPNA2/CDK4/TYK2/JAK1/PIK3CB/TPSD1/CHUK/CASP9/IRF3/NXF1/NFKB1/EP300/APAF1/IRAK4/IFNG/KPNA1/TRAF3/IL6/NUP98/HLA-DOB/PML/RAB11B/HLA-DQA1/PIK3CD/DNAJC3/CXCL8/RAF1 42 KEGG hsa05144 Malaria 16/1364 50/8135 0.005936 0.03138 0.02291 GYPC/THBS4/HGF/SDC1/ITGAL/PECAM1/CD40/SELE/CR1/HBB/CD81/IFNG/COMP/THBS2/IL6/CXCL8 16 KEGG hsa05210 Colorectal cancer 24/1364 86/8135 0.006361 0.03309 0.02417 MAPK3/SMAD3/SOS1/TCF7/EGFR/BAD/RALA/EGF/GSK3B/PIK3CB/LEF1/CASP9/DDB2/EREG/KRAS/MYC/RALGDS/RAC2/BIRC5/PIK3CD/TCF7L2/CDKN1A/NRAS/RAF1 24 KEGG hsa05225 Hepatocellular carcinoma 41/1364 168/8135 0.006743 0.03454 0.02522 GSTA4/WNT5B/MAPK3/PLCG2/SMAD3/HGF/PRKCB/SOS1/TCF7/EGFR/BAD/GSTM4/SMARCD3/NQO1/GSK3B/CDK4/MGST3/PIK3CB/LEF1/WNT11/DDB2/FZD3/LRP5/ARID1A/GSTM5/PBRM1/KRAS/MYC/GSTM3/CSNK1A1/FZD6/FRAT1/FZD2/PIK3CD/TCF7L2/CDKN1A/NRAS/TXNRD2/RAF1/SMARCD2/E2F3 41 KEGG hsa00020 Citrate cycle (TCA cycle) 11/1364 30/8135 0.006962 0.03513 0.02565 SDHC/PC/SDHD/DLD/MDH2/PCK2/PCK1/PDHB/SUCLG1/OGDHL/MDH1 11 KEGG hsa01524 Platinum drug resistance 21/1364 73/8135 0.007127 0.03542 0.02586 GSTA4/BIRC3/MAP3K5/MAPK3/ERCC1/ATM/FAS/BIRC2/BAD/GSTM4/MGST3/ERBB2/PIK3CB/CASP9/GSTM5/APAF1/GSTM3/BIRC5/TOP2A/PIK3CD/CDKN1A 21 KEGG hsa05203 Viral carcinogenesis 48/1364 204/8135 0.007477 0.03661 0.02674 NFKBIA/HLA-C/MAPK3/TRAF1/HLA-G/ATP6V0D1/HLA-F/CCNA2/HLA-A/TRAF5/BAD/CREB3/CHEK1/REL/CCR5/HLA-E/RBPJ/HLA-B/CDK4/HNRNPK/JAK1/PIK3CB/IRF3/NFKB1/EP300/YWHAH/HDAC1/GTF2H3/KRAS/STAT5A/GTF2A2/CDC20/TRAF3/RBL2/ATF2/UBE3A/SCIN/MAPKAPK2/CREB1/UBR4/VDAC3/KAT2B/PIK3CD/ACTN1/ATF4/CDKN1A/NRAS/PRKACB 48 KEGG hsa05416 Viral myocarditis 18/1364 60/8135 0.007705 0.03718 0.02715 SGCA/HLA-C/SGCG/HLA-G/HLA-F/SGCB/HLA-A/HLA-DQB1/ITGAL/HLA-E/HLA-B/PRF1/CD40/CASP9/CD28/RAC2/HLA-DOB/HLA-DQA1 18 KEGG hsa00620 Pyruvate metabolism 15/1364 47/8135 0.007815 0.03718 0.02715 ALDH7A1/ME2/PC/DLD/ACYP2/MDH2/ACAT1/GRHPR/PCK2/ALDH9A1/ALDH3A2/PCK1/PDHB/MDH1/GLO1 15 KEGG hsa04917 Prolactin signaling pathway 20/1364 70/8135 0.00923 0.04329 0.03161 JAK2/STAT1/IRF1/SOCS6/MAPK3/SOS1/SOCS1/TNFRSF11A/GSK3B/TH/PIK3CB/MAPK11/NFKB1/KRAS/STAT5A/SOCS5/PIK3CD/NRAS/RAF1/CISH 20 KEGG hsa01522 Endocrine resistance 26/1364 98/8135 0.009407 0.04351 0.03177 NOTCH1/MAPK3/NCOA3/SOS1/CDKN2C/EGFR/BAD/NOTCH4/CDK4/ERBB2/MED1/PIK3CB/ADCY1/MAPK11/GPER1/HBEGF/KRAS/IGF1/JAG2/NCOR1/PIK3CD/CDKN1A/NRAS/PRKACB/RAF1/E2F3 26 KEGG hsa05135 Yersinia infection 34/1364 137/8135 0.009907 0.04519 0.033 NFKBIA/ACTR3B/MAPK3/ARPC1A/TBK1/GIT2/ACTR3/BAIAP2/CD8A/ITGA5/ROCK1/GSK3B/PIK3CB/CHUK/IRF3/FYB1/WIPF1/MAPK11/ZAP70/NFKB1/ACTR2/IRAK4/ARHGEF7/LCK/RAC2/RPS6KA3/IL6/ITGA4/LAT/PIK3CD/LCP2/CXCL8/ARPC5L/RPS6KA1 34 KEGG hsa04640 Hematopoietic cell lineage 26/1364 99/8135 0.01078 0.04851 0.03542 IL11RA/TFRC/IL7R/IL4R/CD38/CD8A/ITGA5/HLA-DQB1/KIT/CD44/CR1/CD3E/CD3D/CD7/IL6R/IL6/HLA-DOB/CD19/ITGA4/DNTT/HLA-DQA1/ANPEP/IL3RA/CD2/CD3G/EPOR 26 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 26/1364 100/8135 0.01231 0.05466 0.03991 JAK2/STAT1/MAPK3/PLCG2/SMAD3/PRKCB/SERPINE1/PIM1/CDK4/EGR1/PIK3CB/AGT/SELE/MAPK11/NFKB1/NOS3/KRAS/STAT5A/VEGFA/PLCD1/PLCE1/IL6/PIK3CD/COL3A1/CXCL8/NRAS 26 KEGG hsa04330 Notch signaling pathway 17/1364 59/8135 0.01439 0.06304 0.04603 NOTCH1/ADAM17/NOTCH4/RBPJ/MAML1/RFNG/EP300/PSENEN/HDAC1/JAG2/TLE3/CIR1/KAT2B/HES1/APH1B/DTX2/TLE2 17 KEGG hsa05222 Small cell lung cancer 24/1364 92/8135 0.01513 0.06544 0.04778 NFKBIA/BIRC3/LAMC3/TRAF1/TRAF5/BIRC2/CKS1B/BIRC7/CDK4/RXRA/PIK3CB/CHUK/FHIT/CASP9/CKS2/DDB2/LAMA5/NFKB1/APAF1/MYC/TRAF3/PIK3CD/CDKN1A/E2F3 24 KEGG hsa04666 Fc gamma R-mediated phagocytosis 25/1364 97/8135 0.01554 0.06636 0.04846 ACTR3B/SPHK1/MAPK3/ARPC1A/PLCG2/LIMK2/PRKCB/PTPRC/ASAP1/ACTR3/MARCKSL1/PLPP3/PIK3CB/BIN1/PLA2G4C/PLD1/ACTR2/RAC2/SCIN/FCGR2B/LAT/PIK3CD/ARPC5L/RAF1/PLPP1 25 KEGG hsa05211 Renal cell carcinoma 19/1364 69/8135 0.01643 0.06927 0.05058 MAPK3/HGF/SOS1/BAD/ELOB/PIK3CB/RAP1B/PAK2/EP300/PDGFB/KRAS/CUL2/EGLN3/VEGFA/HIF1A/PIK3CD/CDKN1A/NRAS/RAF1 19 KEGG hsa04145 Phagosome 36/1364 152/8135 0.01698 0.0707 0.05162 TAP1/HLA-C/COLEC12/TFRC/THBS4/HLA-G/ATP6V0D1/HLA-F/OLR1/HLA-A/MRC2/ATP6V1F/TUBB2B/ITGA5/HLA-DQB1/HLA-E/PIKFYVE/HLA-B/DYNC1H1/SEC22B/TUBB6/TCIRG1/VAMP3/TUBA4A/MBL2/COMP/THBS2/DYNC1I1/SEC61A2/HLA-DOB/ATP6V0E2/PLA2R1/TAP2/FCGR2B/HLA-DQA1/TUBB2A 36 KEGG hsa04931 Insulin resistance 27/1364 108/8135 0.01824 0.07501 0.05477 NFKBIA/PPP1R3C/PTPRF/PRKCB/INSR/G6PC3/SLC27A6/CREB3/PRKAG1/SLC27A5/PRKAB1/GSK3B/PIK3CB/AGT/PYGM/NFKB1/NOS3/NR1H2/RPS6KA3/PCK2/IL6/PRKCQ/CREB1/PCK1/PIK3CD/OGT/RPS6KA1 27 KEGG hsa03020 RNA polymerase 11/1364 34/8135 0.01921 0.07803 0.05698 POLR2I/POLR2J/POLR2E/POLR2L/POLR3C/POLR2F/POLR2C/POLR1B/POLR2G/POLR2B/POLR1C 11 KEGG hsa04657 IL-17 signaling pathway 24/1364 94/8135 0.0196 0.07863 0.05741 TNFAIP3/NFKBIA/CXCL10/MAPK3/TBK1/TRAF5/GSK3B/CXCL2/MAPK7/CHUK/IL17RB/IL17RC/MAPK11/NFKB1/IFNG/TRAF3/IL6/MMP13/MAPK4/CXCL3/IL17RA/CCL7/CXCL8/CEBPB 24 KEGG hsa05162 Measles 33/1364 139/8135 0.0209 0.08279 0.06045 TNFAIP3/NFKBIA/STAT1/ADAR/TBK1/FAS/SLAMF1/IL2RG/BAD/GSK3B/CDK4/TYK2/JAK1/PIK3CB/CHUK/CASP9/IRF3/CSNK2B/CBLB/HSPA6/CD28/NFKB1/CD3E/APAF1/IRAK4/IL2RB/CD3D/STAT5A/TRAF3/IL6/FCGR2B/PIK3CD/CD3G 33 KEGG hsa00790 Folate biosynthesis 9/1364 26/8135 0.02113 0.08279 0.06045 GCH1/AKR1B1/AKR1B10/QDPR/PCBD1/TH/MOCS2/GGH/AKR1C3 9 KEGG hsa04520 Adherens junction 19/1364 71/8135 0.02213 0.08567 0.06256 MAPK3/SMAD3/PTPRF/INSR/TCF7/BAIAP2/EGFR/NECTIN2/ERBB2/LEF1/CSNK2B/EP300/NLK/RAC2/IQGAP1/ACP1/SORBS1/ACTN1/TCF7L2 19 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 25/1364 100/8135 0.02252 0.08619 0.06294 CXCL9/TNFRSF1B/CXCL10/CCL5/CXCL13/CCL18/CXCL11/IL2RG/CX3CR1/CCR5/TNFRSF14/CXCL2/CXCR4/CCL8/CCL13/IL2RB/IL6R/IL6/XCL1/CXCL3/TNFSF14/CCR7/CCL7/CXCR2/CXCL8 25 KEGG hsa05207 Chemical carcinogenesis - receptor activation 47/1364 212/8135 0.02345 0.08873 0.06479 GSTA4/JAK2/EPHX1/AR/MAPK3/PRKCB/SOS1/EPHX2/EGFR/BAD/CREB3/KPNA2/GSTM4/EGF/MGST3/FGF5/RXRA/PIK3CB/FGF20/ADCY1/ARRB1/NFKB1/FGF18/GSTM5/KPNA3/KPNB1/ADRB2/KRAS/MYC/GSTM3/CHRNA3/STAT5A/UGT2B17/VEGFA/KPNA1/RPS6KA3/ATF2/CREB1/BIRC5/CACNA1D/AHR/PIK3CD/ATF4/NRAS/PRKACB/RAF1/RPS6KA1 47 KEGG hsa05320 Autoimmune thyroid disease 15/1364 53/8135 0.02438 0.09121 0.0666 HLA-C/FAS/HLA-G/HLA-F/HLA-A/HLA-DQB1/HLA-E/CTLA4/HLA-B/PRF1/CD40/GZMB/CD28/HLA-DOB/HLA-DQA1 15 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 5/1364 11/8135 0.02502 0.09259 0.06761 HPD/VKORC1/COQ6/NQO1/GGCX 5 KEGG hsa05218 Melanoma 19/1364 72/8135 0.02548 0.09326 0.0681 MAPK3/HGF/EGFR/BAD/EGF/CDK4/FGF5/PIK3CB/FGF20/DDB2/FGF18/PDGFB/KRAS/IGF1/PIK3CD/CDKN1A/NRAS/RAF1/E2F3 19 KEGG hsa00480 Glutathione metabolism 16/1364 58/8135 0.02592 0.09383 0.06852 HPGDS/GSTA4/LAP3/GSTM4/GPX3/PRDX6/MGST3/RRM2/SMS/GPX1/GPX4/GSTM5/GSTM3/SRM/GGCT/ANPEP 16 KEGG hsa04144 Endocytosis 54/1364 251/8135 0.02776 0.09939 0.07258 ACTR3B/HLA-C/VPS37C/TFRC/ARPC1A/GIT2/SH3GL1/SMAD3/HLA-G/IL2RG/HLA-F/HLA-A/ASAP1/ACTR3/ZFYVE16/EGFR/DAB2/CAPZA1/CCR5/HLA-E/HLA-B/RAB11FIP1/CHMP1B/BIN1/AP2M1/EHD3/PLD1/CHMP6/ACAP2/WIPF1/ARRB1/FOLR1/CBLB/HSPA6/ACAP1/CXCR4/USP8/ARAP3/EPS15/PRKCI/SNX2/ACTR2/FOLR2/CHMP2A/IL2RB/KIF5C/PML/RAB11B/CXCR2/WASHC2C/GRK6/FGFR4/ARPC5L/RUFY2 54 KEGG hsa04614 Renin-angiotensin system 8/1364 23/8135 0.02828 0.1002 0.07316 CPA3/CMA1/CTSA/AGT/CTSG/LNPEP/ANPEP/PREP 8 KEGG hsa04072 Phospholipase D signaling pathway 34/1364 148/8135 0.03045 0.1067 0.07794 SPHK1/MS4A2/MAPK3/AGPAT1/PLCG2/AGPAT5/FCER1A/SOS1/INSR/EGFR/RALA/KIT/EGF/DGKA/PLPP3/PIK3CB/AGT/F2R/PLA2G4C/PLD1/ADCY1/PTGFR/DGKZ/PIK3R5/PDGFB/KRAS/RALGDS/CXCR2/PIK3CD/CXCL8/NRAS/LPAR2/RAF1/PLPP1 34 KEGG hsa00230 Purine metabolism 30/1364 128/8135 0.03145 0.1091 0.07965 HDDC2/NME4/ENPP1/NME7/IMPDH2/NT5C2/ADK/PDE1A/ENTPD4/PGM1/ADA/RRM2/NME3/PDE4B/GUCY1A1/NUDT9/DGUOK/ADCY1/FHIT/AK1/NPR2/AK6/PRPS2/GUCY1B1/PNP/GUK1/PRPS1/PAPSS1/PDE11A/AMPD3 30 KEGG hsa03013 Nucleocytoplasmic transport 26/1364 108/8135 0.03178 0.1091 0.07966 UBE2I/NUP58/NUP153/THOC2/NXF3/NUP160/XPO6/KPNA2/TPR/THOC1/SEC13/RANBP2/NMD3/NUP50/NXF1/TNPO1/NUP43/KPNA3/SNUPN/KPNB1/KPNA1/SENP2/NUP210/NUP98/NDC1/CSE1L 26 KEGG hsa04935 Growth hormone synthesis, secretion and action 28/1364 119/8135 0.03508 0.1192 0.08703 JAK2/STAT1/MAPK3/PLCG2/PRKCB/SOS1/SOCS1/CREB3/GSK3B/PIK3CB/ITPR2/ADCY1/MAPK11/GHSR/EP300/KRAS/STAT5A/IGF1/ATF2/CREB1/GHR/CACNA1D/PIK3CD/SSTR5/ATF4/NRAS/PRKACB/RAF1 28 KEGG hsa05230 Central carbon metabolism in cancer 18/1364 70/8135 0.03715 0.125 0.09125 MAPK3/SLC7A5/EGFR/SIRT3/KIT/ERBB2/SCO2/PIK3CB/NTRK1/PFKM/KRAS/MYC/PDK1/PDHB/HIF1A/PIK3CD/NRAS/RAF1 18 KEGG hsa05214 Glioma 19/1364 75/8135 0.03789 0.1262 0.09213 MAPK3/PLCG2/PRKCB/SOS1/EGFR/EGF/CDK4/PIK3CB/DDB2/PDGFB/KRAS/IGF1/CAMK1/PIK3CD/CAMK2B/CDKN1A/NRAS/RAF1/E2F3 19 KEGG hsa05220 Chronic myeloid leukemia 19/1364 76/8135 0.04287 0.1413 0.1032 NFKBIA/MAPK3/SMAD3/SOS1/BAD/CDK4/PIK3CB/CHUK/DDB2/NFKB1/HDAC1/KRAS/MYC/STAT5A/PIK3CD/CDKN1A/NRAS/RAF1/E2F3 19 KEGG hsa05145 Toxoplasmosis 26/1364 112/8135 0.04768 0.1557 0.1137 NFKBIA/JAK2/STAT1/BIRC3/LAMC3/MAPK3/BIRC2/SOCS1/BAD/HLA-DQB1/BIRC7/CCR5/TYK2/JAK1/CD40/CHUK/CASP9/MAPK11/PIK3R5/HSPA6/LAMA5/NFKB1/IRAK4/IFNG/HLA-DOB/HLA-DQA1 26 KEGG hsa04380 Osteoclast differentiation 29/1364 128/8135 0.05057 0.1631 0.1191 NFKBIA/STAT1/TREM2/TNFRSF11B/MAPK3/PLCG2/LILRB2/LILRA2/SOCS1/TNFRSF11A/TYK2/JAK1/PIK3CB/CHUK/PPARG/MAPK11/NFKB1/RELB/CALCR/CYLD/LCK/IFNG/TYROBP/PPP3CA/CREB1/FCGR2B/PIK3CD/LCP2/FHL2 29 KEGG hsa04514 Cell adhesion molecules 33/1364 149/8135 0.05174 0.1631 0.1191 HLA-C/CDH2/HLA-G/PTPRF/HLA-F/HLA-A/PTPRC/SDC1/CD8A/HLA-DQB1/CLDN11/ITGAL/NEO1/HLA-E/CTLA4/HLA-B/NECTIN2/PECAM1/CD40/CADM3/SELE/CDH5/CD28/ITGB7/HLA-DOB/CD58/CNTN1/NRCAM/ITGA4/VCAN/HLA-DQA1/CD2/ALCAM 33 KEGG hsa05226 Gastric cancer 33/1364 149/8135 0.05174 0.1631 0.1191 WNT5B/MAPK3/SMAD3/HGF/SOS1/TCF7/EGFR/EGF/GSK3B/ERBB2/FGF5/RXRA/PIK3CB/LEF1/WNT11/FGF20/DDB2/FZD3/LRP5/FGF18/KRAS/MYC/CSNK1A1/FZD6/FRAT1/FZD2/PIK3CD/TCF7L2/CDKN1A/NRAS/RAF1/ABCB1/E2F3 33 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 9/1364 30/8135 0.05193 0.1631 0.1191 GCSH/PCCB/CAT/DLD/MDH2/ACAT1/GRHPR/HYI/MDH1 9 KEGG hsa04810 Regulation of actin cytoskeleton 46/1364 218/8135 0.05308 0.1652 0.1206 IQGAP2/ACTR3B/MAPK3/ARPC1A/LIMK2/SOS1/ACTR3/ITGAE/BAIAP2/ITGA5/EGFR/ITGAX/ROCK1/ITGAL/PFN2/EGF/PIKFYVE/FGF5/PIK3CB/FGF20/F2R/CYFIP2/PPP1R12A/SSH3/CXCR4/GNG12/FGF18/PAK2/ITGB7/PDGFB/ACTR2/ARHGAP35/ARHGEF7/KRAS/RAC2/IQGAP1/SCIN/DIAPH2/ITGA4/PIK3CD/ACTN1/FGFR4/ARPC5L/NRAS/LPAR2/RAF1 46 KEGG hsa04612 Antigen processing and presentation 19/1364 78/8135 0.05422 0.1667 0.1217 TAP1/HLA-C/LGMN/RFX5/HLA-G/HLA-F/HLA-A/CD8A/HLA-DQB1/HLA-E/HLA-B/TAPBP/HSPA6/IFNG/HLA-DOB/TAP2/CREB1/NFYC/HLA-DQA1 19 KEGG hsa04934 Cushing syndrome 34/1364 155/8135 0.05505 0.1667 0.1217 WNT5B/MAPK3/CDKN2C/TCF7/EGFR/CREB3/KCNK3/CYP11A1/GSK3B/CDK4/ITPR2/LEF1/AGT/WNT11/ADCY1/FZD3/RAP1B/WDR5B/USP8/KMT2D/FZD6/ATF2/CREB1/FZD2/CACNA1D/AHR/CRHR2/CAMK2B/TCF7L2/ATF4/CDKN1A/PDE11A/PRKACB/E2F3 34 KEGG hsa04020 Calcium signaling pathway 50/1364 240/8135 0.05506 0.1667 0.1217 SPHK1/TACR2/ATP2A3/PLCG2/SLC25A4/HGF/PRKCB/CD38/PDE1A/EGFR/ATP2B2/NTRK2/EGF/ERBB2/FGF5/ITPR2/FGF20/HTR2B/F2R/ADCY1/ASPH/PTGFR/NTRK1/ATP2B1/CXCR4/FGF18/NOS3/PDGFB/ADRB2/MCOLN3/KDR/CCKAR/VEGFA/PLCD1/PLCE1/P2RX4/ATP2B4/CAMK1/PPP3CA/RYR2/TPCN1/ORAI3/VDAC3/CACNA1D/GNA14/CAMK2B/FGFR4/MCOLN1/ORAI2/PRKACB 50 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 8/1364 26/8135 0.05689 0.1707 0.1246 PIGT/GPAA1/PIGK/PIGA/PIGP/PIGH/PIGZ/PIGC 8 KEGG hsa02010 ABC transporters 12/1364 45/8135 0.06268 0.1864 0.1361 TAP1/ABCC6/ABCC10/ABCC4/ABCA8/ABCA3/ABCC8/ABCC1/ABCA2/TAP2/ABCA6/ABCB1 12 KEGG hsa05160 Hepatitis C 34/1364 157/8135 0.06419 0.1892 0.1381 NFKBIA/CXCL10/STAT1/MAPK3/TBK1/FAS/SOS1/CFLAR/EGFR/BAD/CLDN11/EGF/GSK3B/CDK4/TYK2/RXRA/JAK1/PIK3CB/CHUK/CASP9/IRF3/NFKB1/YWHAH/CD81/APAF1/IFNG/KRAS/MYC/TRAF3/PIK3CD/CDKN1A/NRAS/RAF1/E2F3 34 KEGG hsa05205 Proteoglycans in cancer 43/1364 205/8135 0.06486 0.1892 0.1381 WNT5B/MAPK3/PLCG2/FAS/HGF/PRKCB/SOS1/SDC1/ITGA5/EGFR/ROCK1/ERBB2/PIK3CB/ITPR2/CD44/WNT11/PPP1R12A/ANK3/MAPK11/FZD3/HBEGF/KRAS/MYC/KDR/IGF1/CD63/VEGFA/HSPB2/IQGAP1/FZD6/PLCE1/FZD2/HIF1A/FLNA/PIK3CD/CAMK2B/SMO/CDKN1A/NRAS/PRKACB/CTTN/HOXD10/RAF1 43 KEGG hsa04650 Natural killer cell mediated cytotoxicity 29/1364 131/8135 0.06532 0.1892 0.1381 HLA-C/MAPK3/PLCG2/FAS/HLA-G/MICB/PRKCB/SOS1/HLA-A/ITGAL/HLA-E/HLA-B/PIK3CB/PRF1/GZMB/ZAP70/LCK/IFNG/KRAS/ULBP2/RAC2/CD247/TYROBP/PPP3CA/LAT/PIK3CD/LCP2/NRAS/RAF1 29 KEGG hsa01232 Nucleotide metabolism 20/1364 85/8135 0.06718 0.1927 0.1407 HDDC2/TK2/NME4/ENPP1/NME7/IMPDH2/NT5C2/ADK/ENTPD4/ADA/RRM2/NME3/DGUOK/TYMP/AK1/AK6/PNP/GUK1/DCTD/AMPD3 20 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 17/1364 70/8135 0.0677 0.1927 0.1407 NFKBIA/CCL5/ADAM17/PLCG2/ATP6V0D1/ATP6V1F/EGFR/CXCL2/CHUK/MAPK11/TCIRG1/NFKB1/HBEGF/ATP6V0E2/CXCL3/CXCR2/CXCL8 17 KEGG hsa00920 Sulfur metabolism 4/1364 10/8135 0.07092 0.2001 0.1461 SELENBP1/SUOX/MPST/PAPSS1 4 KEGG hsa04723 Retrograde endocannabinoid signaling 32/1364 148/8135 0.07213 0.2018 0.1474 MAPK3/NDUFC1/NDUFS4/NDUFA13/PRKCB/ABHD6/NDUFA4L2/GABRB1/NDUFA4/NDUFB4/GNG3/NDUFA8/GABRA4/ITPR2/ADCY1/GRIA2/MAPK11/NDUFB6/GNG12/NDUFA6/NDUFB2/NDUFB11/NDUFB7/NDUFA10/NDUFA3/NDUFB8/NDUFS7/GNB2/NDUFS3/NDUFA2/CACNA1D/PRKACB 32 KEGG hsa00330 Arginine and proline metabolism 13/1364 51/8135 0.07397 0.2053 0.1499 ALDH7A1/GAMT/GOT1/LAP3/AGMAT/SMS/NOS3/SRM/ALDH9A1/GATM/ALDH3A2/ALDH18A1/PYCR1 13 KEGG hsa04060 Cytokine-cytokine receptor interaction 59/1364 295/8135 0.0779 0.2144 0.1566 CXCL9/IL11RA/CSF2RB/IL15RA/TNFRSF1B/CXCL10/CCL5/IL32/TNFRSF11B/IL21R/IL27RA/CXCL13/IL15/FAS/CCL18/CXCL11/IL7R/IL2RG/IL4R/TNFRSF11A/CX3CR1/TNFRSF21/CCR5/TNFRSF14/BMP4/CXCL2/CTF1/IL1RL2/CD40/GDF5/TNFRSF17/IL17RB/IL17RC/CXCR4/CD27/CCL8/CCL13/IFNG/IL2RB/IL6R/IL6/NGFR/XCL1/IL13RA2/TNFSF4/CXCL3/TNFSF14/CCR7/GHR/IL17RA/GDF9/TNFSF8/CCL7/CXCR2/INHBB/IL3RA/CD70/CXCL8/EPOR 59 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 10/1364 37/8135 0.07863 0.2146 0.1567 ATP1B1/MAPK3/PRKCB/HSD11B2/INSR/PIK3CB/KRAS/IGF1/NR3C2/PIK3CD 10 KEGG hsa03420 Nucleotide excision repair 12/1364 47/8135 0.08307 0.2226 0.1626 CETN2/ERCC1/POLD2/RPA1/POLD4/RPA3/DDB2/ERCC8/GTF2H3/CCNH/ERCC2/MNAT1 12 KEGG hsa00650 Butanoate metabolism 8/1364 28/8135 0.08352 0.2226 0.1626 ECHS1/ACSM5/BDH2/HMGCL/HADH/OXCT1/ACAT1/HMGCS2 8 KEGG hsa05134 Legionellosis 14/1364 57/8135 0.08475 0.2226 0.1626 NFKBIA/CXCL2/SEC22B/CASP9/HSPA6/CR1/NFKB1/APAF1/IL6/TLR5/NAIP/CXCL3/CLK1/CXCL8 14 KEGG hsa04720 Long-term potentiation 16/1364 67/8135 0.08475 0.2226 0.1626 MAPK3/PRKCB/ITPR2/ADCY1/GRIA2/RAP1B/EP300/KRAS/RPS6KA3/PPP3CA/CAMK2B/ATF4/NRAS/PRKACB/RAF1/RPS6KA1 16 KEGG hsa04213 Longevity regulating pathway - multiple species 15/1364 62/8135 0.08491 0.2226 0.1626 INSR/PRKAG1/PRKAB1/PIK3CB/CAT/ADCY1/CRYAB/HSPA6/HDAC1/KRAS/IGF1/SOD1/PIK3CD/NRAS/PRKACB 15 KEGG hsa00051 Fructose and mannose metabolism 9/1364 33/8135 0.08824 0.2292 0.1674 AKR1B1/AKR1B10/MPI/SORD/PFKFB3/PFKM/GMDS/ALDOC/PMM1 9 KEGG hsa04310 Wnt signaling pathway 35/1364 167/8135 0.08946 0.2292 0.1674 WIF1/SFRP1/WNT5B/CHD8/SKP1/SMAD3/PRKCB/CBY1/TCF7/CTNNBIP1/GSK3B/LEF1/WNT11/FZD3/LRP5/CSNK2B/LGR5/EP300/NLK/CXXC4/MYC/DKK4/SENP2/CSNK1A1/RAC2/FZD6/TLE3/PPP3CA/FRAT1/FZD2/CAMK2B/TLE2/TCF7L2/SERPINF1/PRKACB 35 KEGG hsa04540 Gap junction 20/1364 88/8135 0.09013 0.2292 0.1674 MAPK3/PRKCB/SOS1/TUBB2B/EGFR/EGF/ITPR2/MAPK7/GUCY1A1/HTR2B/ADCY1/TUBB6/GUCY1B1/PDGFB/KRAS/TUBA4A/NRAS/PRKACB/RAF1/TUBB2A 20 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 5/1364 15/8135 0.09146 0.2292 0.1674 FUT1/B3GALNT1/HEXA/ST3GAL2/ST3GAL1 5 KEGG hsa00071 Fatty acid degradation 11/1364 43/8135 0.09345 0.2292 0.1674 ALDH7A1/ECI2/ECHS1/ACSL5/HADH/ECI1/ACAT1/ALDH9A1/ALDH3A2/ACAA2/ACADVL 11 KEGG hsa04115 p53 signaling pathway 17/1364 73/8135 0.09355 0.2292 0.1674 ATM/FAS/CHEK2/ATR/SERPINE1/CHEK1/SIVA1/CDK4/RRM2/CASP9/DDB2/APAF1/CCNB2/IGF1/CCNB1/CDKN1A/GTSE1 17 KEGG hsa04620 Toll-like receptor signaling pathway 23/1364 104/8135 0.09359 0.2292 0.1674 CXCL9/NFKBIA/CXCL10/STAT1/CCL5/MAPK3/TBK1/CXCL11/PIK3CB/MAP3K8/CD40/CHUK/IRF3/TOLLIP/MAPK11/NFKB1/IRAK4/TRAF3/IL6/TLR5/PIK3CD/CXCL8/TLR8 23 KEGG hsa04664 Fc epsilon RI signaling pathway 16/1364 68/8135 0.09438 0.2292 0.1674 MS4A2/MAPK3/PLCG2/ALOX5AP/FCER1A/SOS1/PIK3CB/PLA2G4C/MAPK11/KRAS/RAC2/LAT/PIK3CD/LCP2/NRAS/RAF1 16 KEGG hsa00310 Lysine degradation 15/1364 63/8135 0.09498 0.2292 0.1674 NSD2/ALDH7A1/ECHS1/EZH2/SETMAR/HADH/DLD/SETD1B/SMYD2/KMT2D/ACAT1/ALDH9A1/ALDH3A2/SUV39H2/SETD2 15 KEGG hsa03250 Viral life cycle - HIV-1 15/1364 63/8135 0.09498 0.2292 0.1674 NUP153/APOBEC3C/SERINC5/CCR5/SAMHD1/RANBP2/CHMP6/CCNT2/CXCR4/EP300/CPSF7/ELL2/PIN1/APOBEC3B/KAT2B 15 KEGG hsa04623 Cytosolic DNA-sensing pathway 15/1364 63/8135 0.09498 0.2292 0.1674 NFKBIA/AIM2/CXCL10/CCL5/ADAR/TBK1/POLR2E/POLR2L/POLR3C/POLR2F/CHUK/IRF3/NFKB1/IL6/POLR1C 15 KEGG hsa01200 Carbon metabolism 25/1364 115/8135 0.09754 0.2337 0.1706 GCSH/SDS/GOT1/ECHS1/SDHC/ME2/PCCB/ENO2/CAT/PC/SDHD/DLD/PRPS2/PFKM/CPS1/MDH2/ACAT1/ALDH6A1/PDHB/PRPS1/ALDOC/SUCLG1/OGDHL/ESD/MDH1 25 KEGG hsa04672 Intestinal immune network for IgA production 12/1364 49/8135 0.1072 0.2549 0.1861 IL15RA/IL15/HLA-DQB1/CD40/TNFRSF17/CD28/CXCR4/ITGB7/IL6/HLA-DOB/ITGA4/HLA-DQA1 12 KEGG hsa00983 Drug metabolism - other enzymes 18/1364 80/8135 0.112 0.2643 0.193 GSTA4/CES1/TK2/NME4/NME7/GUSB/IMPDH2/CES2/GSTM4/MGST3/DPYS/RRM2/NME3/TYMP/GSTM5/NAT2/GSTM3/UGT2B17 18 KEGG hsa04916 Melanogenesis 22/1364 101/8135 0.1127 0.2643 0.193 WNT5B/MAPK3/PRKCB/TCF7/CREB3/KIT/GSK3B/LEF1/WNT11/ADCY1/FZD3/EP300/KRAS/FZD6/CREB1/DCT/FZD2/CAMK2B/TCF7L2/NRAS/PRKACB/RAF1 22 KEGG hsa03320 PPAR signaling pathway 17/1364 75/8135 0.1139 0.2651 0.1936 ACOX2/OLR1/SLC27A6/SLC27A5/ACSL5/RXRA/PPARG/LPL/GK/PLIN2/SCD5/PCK2/SCP2/PCK1/FABP7/HMGCS2/SORBS1 17 KEGG hsa01523 Antifolate resistance 8/1364 30/8135 0.1163 0.2691 0.1965 ABCC4/CHUK/FOLR1/NFKB1/ABCC1/GGH/FOLR2/IL6 8 KEGG hsa05321 Inflammatory bowel disease 15/1364 65/8135 0.1173 0.2693 0.1966 STAT1/IL21R/SMAD3/IL2RG/RORA/IL4R/HLA-DQB1/NFKB1/NOD2/STAT4/IFNG/IL6/TLR5/HLA-DOB/HLA-DQA1 15 KEGG hsa00260 Glycine, serine and threonine metabolism 10/1364 40/8135 0.1205 0.2732 0.1995 CBS/GCSH/ALDH7A1/SDS/GAMT/GCAT/DLD/GRHPR/GATM/SRR 10 KEGG hsa04979 Cholesterol metabolism 12/1364 50/8135 0.1206 0.2732 0.1995 LIPC/LRPAP1/APOE/ANGPTL8/APOC1/LPL/TSPO/LIPA/VDAC3/SORT1/NPC1/VAPA 12 KEGG hsa00561 Glycerolipid metabolism 14/1364 61/8135 0.1315 0.296 0.2161 AKR1B1/AKR1B10/ALDH7A1/AGPAT1/LIPC/AGPAT5/DGKA/PLPP3/DGKZ/LPL/GK/ALDH9A1/ALDH3A2/PLPP1 14 KEGG hsa00052 Galactose metabolism 8/1364 31/8135 0.135 0.3001 0.2191 AKR1B1/AKR1B10/G6PC3/B4GALT2/PGM1/PFKM/LCT/GAA 8 KEGG hsa05231 Choline metabolism in cancer 21/1364 98/8135 0.1352 0.3001 0.2191 MAPK3/SLC22A4/PRKCB/SOS1/EGFR/EGF/DGKA/PLPP3/PIK3CB/PLA2G4C/PLD1/DGKZ/PDGFB/KRAS/RALGDS/RAC2/HIF1A/PIK3CD/NRAS/RAF1/PLPP1 21 KEGG hsa04912 GnRH signaling pathway 20/1364 93/8135 0.1385 0.3035 0.2216 MAPK3/PRKCB/SOS1/EGFR/EGR1/ITPR2/MAPK7/PLA2G4C/PLD1/ADCY1/MAPK11/MAP3K3/HBEGF/KRAS/CACNA1D/CAMK2B/ATF4/NRAS/PRKACB/RAF1 20 KEGG hsa05323 Rheumatoid arthritis 20/1364 93/8135 0.1385 0.3035 0.2216 CCL5/ANGPT1/IL15/ATP6V0D1/ATP6V1F/HLA-DQB1/ITGAL/TNFRSF11A/CTLA4/CXCL2/CD28/TCIRG1/IFNG/VEGFA/IL6/HLA-DOB/ATP6V0E2/CXCL3/HLA-DQA1/CXCL8 20 KEGG hsa05152 Tuberculosis 36/1364 180/8135 0.1421 0.3075 0.2245 JAK2/SPHK1/STAT1/RFX5/MAPK3/RIPK2/MALT1/ATP6V0D1/MRC2/ITGAX/BAD/HLA-DQB1/JAK1/CASP9/MAPK11/CR1/TCIRG1/NFKB1/NOD2/EP300/APAF1/IRAK4/IFNG/IL6/HLA-DOB/PLA2R1/PPP3CA/BCL10/CREB1/NFYC/FCGR2B/HLA-DQA1/CAMK2B/CEBPB/CAMP/RAF1 36 KEGG hsa04625 C-type lectin receptor signaling pathway 22/1364 104/8135 0.1422 0.3075 0.2245 NFKBIA/STAT1/IRF1/MAPK3/PLCG2/MALT1/PIK3CB/ITPR2/CHUK/MAPK11/CBLB/NFKB1/RELB/CYLD/KRAS/IL6/PPP3CA/MAPKAPK2/BCL10/PIK3CD/NRAS/RAF1 22 KEGG hsa01240 Biosynthesis of cofactors 31/1364 153/8135 0.1452 0.312 0.2278 GCH1/HPD/VKORC1/NME4/MTHFD2/HAAO/NME7/GUSB/FECH/MPI/PNPO/DHRS3/IDO1/COQ6/NQO1/UROD/MOCS2/UROS/NME3/LIPT1/AK1/DLD/AK6/GGH/NADSYN1/UGT2B17/CPOX/ALDH3A2/GGCX/PANK3/PMM1 31 KEGG hsa05131 Shigellosis 48/1364 247/8135 0.1466 0.3129 0.2285 NFKBIA/ACTR3B/FNBP1/UBE2D4/CCL5/MAPK3/ARPC1A/PLCG2/TNIP1/TBK1/RIPK2/SKP1/ATM/MALT1/TRAF5/ACTR3/ITGA5/EGFR/ROCK1/PFN2/GSK3B/CASP4/PIK3CB/ITPR2/CAST/CAPNS1/RRAGA/ARHGEF2/CD44/CHUK/IRF3/MAPK11/NFKB1/UBB/ACTR2/PLCD1/PLCE1/TLR5/NAIP/PRKCQ/GLMN/BCL10/PIK3CD/ACTN1/CXCL8/ARPC5L/CTTN/TLN2 48 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 29/1364 143/8135 0.1535 0.3228 0.2357 JAK2/JARID2/WNT5B/MAPK3/SMAD3/TCF7/GSK3B/JAK1/PIK3CB/BMP4/WNT11/ID4/PCGF1/MAPK11/FZD3/KRAS/MYC/KAT6A/IGF1/FZD6/ID3/FZD2/INHBB/NEUROG1/PIK3CD/FGFR4/SMAD1/NRAS/RAF1 29 KEGG hsa00380 Tryptophan metabolism 10/1364 42/8135 0.154 0.3228 0.2357 ALDH7A1/HAAO/ECHS1/IDO1/CAT/HADH/DLD/ACAT1/ALDH9A1/ALDH3A2 10 KEGG hsa04921 Oxytocin signaling pathway 31/1364 154/8135 0.1541 0.3228 0.2357 MYL6B/MAPK3/PRKCB/CD38/EGFR/ROCK1/PRKAG1/KCNJ2/PRKAB1/ITPR2/MAPK7/GUCY1A1/PLA2G4C/ADCY1/PPP1R12A/NPR2/PIK3R5/GUCY1B1/NOS3/KRAS/CAMK1/PPP3CA/RYR2/CACNB2/CACNA1D/CACNA2D3/CAMK2B/CDKN1A/NRAS/PRKACB/RAF1 31 KEGG hsa03450 Non-homologous end-joining 4/1364 13/8135 0.1605 0.3341 0.2439 DCLRE1C/MRE11/RAD50/DNTT 4 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 22/1364 106/8135 0.1641 0.3394 0.2478 MAPK3/PTH1R/PRKCB/EGFR/CREB3/EGR1/RXRA/ITPR2/PDE4B/PLD1/ADCY1/ARRB1/LRP5/HBEGF/ATF2/MMP13/CREB1/MAFB/ATF4/CDKN1A/PRKACB/RAF1 22 KEGG hsa04150 mTOR signaling pathway 31/1364 156/8135 0.1728 0.3552 0.2594 WNT5B/DDIT4/MAPK3/SLC7A5/PRKCB/SOS1/INSR/ATP6V1F/DEPTOR/SEC13/GSK3B/PIK3CB/RRAGA/WNT11/CHUK/FZD3/LRP5/GRB10/PRR5L/KRAS/IGF1/RPS6KA3/LAMTOR2/FZD6/MLST8/FZD2/TTI1/PIK3CD/NRAS/RAF1/RPS6KA1 31 KEGG hsa04510 Focal adhesion 39/1364 201/8135 0.1785 0.3648 0.2663 BIRC3/LAMC3/MAPK3/PGF/THBS4/HGF/PRKCB/SOS1/BIRC2/ITGA5/EGFR/ROCK1/BAD/EGF/GSK3B/ERBB2/PIK3CB/PPP1R12A/CHAD/RAP1B/LAMA5/PAK2/ITGB7/PDGFB/ARHGAP35/COMP/KDR/THBS2/IGF1/VEGFA/RAC2/COL6A3/ITGA4/PARVB/FLNA/PIK3CD/ACTN1/RAF1/TLN2 39 KEGG hsa05142 Chagas disease 21/1364 102/8135 0.1809 0.3665 0.2676 NFKBIA/CCL5/MAPK3/FAS/CFLAR/SERPINE1/PIK3CB/CHUK/ADCY1/MAPK11/NFKB1/CD3E/IRAK4/IFNG/CD3D/CD247/IL6/GNA14/PIK3CD/CXCL8/CD3G 21 KEGG hsa04725 Cholinergic synapse 23/1364 113/8135 0.1823 0.3665 0.2676 JAK2/MAPK3/KCNQ1/PRKCB/CREB3/KCNJ2/GNG3/PIK3CB/ITPR2/ADCY1/PIK3R5/GNG12/KCNQ3/KRAS/CHRNA3/GNB2/CREB1/CACNA1D/PIK3CD/CAMK2B/ATF4/NRAS/PRKACB 23 KEGG hsa04611 Platelet activation 25/1364 124/8135 0.183 0.3665 0.2676 PTGS1/RASGRP1/TBXAS1/MAPK3/PLCG2/ROCK1/PIK3CB/ITPR2/GUCY1A1/F2R/PLA2G4C/ADCY1/PPP1R12A/MAPK11/PIK3R5/RAP1B/GUCY1B1/NOS3/PRKCI/ARHGAP35/PIK3CD/COL3A1/LCP2/PRKACB/TLN2 25 KEGG hsa04911 Insulin secretion 18/1364 86/8135 0.1838 0.3665 0.2676 ATP1B1/KCNN3/PRKCB/CREB3/ADCY1/ABCC8/PCLO/CCKAR/KCNMB2/ATF2/VAMP2/KCNN2/RYR2/CREB1/CACNA1D/CAMK2B/ATF4/PRKACB 18 KEGG hsa04071 Sphingolipid signaling pathway 24/1364 119/8135 0.1885 0.3736 0.2728 ADORA3/SPHK1/MS4A2/MAP3K5/MAPK3/FCER1A/PRKCB/ROCK1/CERS6/PIK3CB/S1PR1/ASAH1/CERS4/PLD1/MAPK11/CERS2/NFKB1/ABCC1/NOS3/KRAS/RAC2/PIK3CD/NRAS/RAF1 24 KEGG hsa04962 Vasopressin-regulated water reabsorption 10/1364 44/8135 0.1917 0.3777 0.2758 CREB3/DCTN6/DYNC1H1/AQP2/DCTN2/DYNC1I1/VAMP2/CREB1/RAB11B/PRKACB 10 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/1364 14/8135 0.1966 0.3851 0.2812 B4GALT2/ST3GAL2/FUT8/ST3GAL1 4 KEGG hsa04925 Aldosterone synthesis and secretion 20/1364 98/8135 0.1993 0.3881 0.2834 ATP1B1/PRKD2/PRKCB/ATP2B2/CREB3/KCNK3/CYP11A1/PRKD3/ITPR2/AGT/ADCY1/ATP2B1/ATF2/ATP2B4/CAMK1/CREB1/CACNA1D/CAMK2B/ATF4/PRKACB 20 KEGG hsa04910 Insulin signaling pathway 27/1364 137/8135 0.2054 0.3972 0.29 PPP1R3C/PRKAR2A/MAPK3/SH2B2/PTPRF/SOS1/INSR/G6PC3/SOCS1/BAD/PRKAG1/PRKAB1/GSK3B/EXOC7/PIK3CB/PYGM/CBLB/PRKCI/KRAS/PCK2/MKNK2/PCK1/PIK3CD/SORBS1/NRAS/PRKACB/RAF1 27 KEGG hsa05110 Vibrio cholerae infection 11/1364 50/8135 0.2064 0.3972 0.29 PLCG2/KCNQ1/ATP6V0D1/KDELR3/ATP6V1F/TCIRG1/SEC61A2/ATP6V0E2/ERO1A/TJP2/PRKACB 11 KEGG hsa04360 Axon guidance 35/1364 182/8135 0.2097 0.3986 0.2911 WNT5B/UNC5C/MAPK3/SEMA4D/PLCG2/LIMK2/SEMA4A/SEMA3A/ROCK1/SEMA4C/NEO1/NCK2/EFNA5/GSK3B/PIK3CB/SEMA3F/FZD3/EPHB6/EFNB1/SSH3/CXCR4/PAK2/KRAS/RAC2/EPHA4/PPP3CA/SEMA3E/PLXNA1/PIK3CD/CAMK2B/SMO/NRAS/ABLIM3/EPHA3/RAF1 35 KEGG hsa05140 Leishmaniasis 16/1364 77/8135 0.21 0.3986 0.2911 NFKBIA/JAK2/STAT1/MAPK3/PRKCB/HLA-DQB1/MARCKSL1/JAK1/MAPK11/CR1/NFKB1/IRAK4/IFNG/HLA-DOB/ITGA4/HLA-DQA1 16 KEGG hsa04141 Protein processing in endoplasmic reticulum 33/1364 171/8135 0.2117 0.3986 0.2911 MAP3K5/UBE2D4/HERPUD1/SKP1/SEC24A/SIL1/UBE2J1/HSPH1/LMAN2/ERO1B/DNAJC1/SEC13/UBXN4/ATF6/DAD1/DNAJA1/PRKN/MBTPS1/CRYAB/HSPA6/MAN1C1/SEC61A2/SSR2/MAN1B1/ERO1A/EDEM1/NGLY1/DDOST/UBQLN4/BAG1/UBXN8/DNAJC3/ATF4 33 KEGG hsa03022 Basal transcription factors 10/1364 45/8135 0.2119 0.3986 0.2911 GTF2IRD1/TAF10/GTF2H3/TAF9B/GTF2A2/CCNH/TAF7/ERCC2/MNAT1/TAF2 10 KEGG hsa04137 Mitophagy - animal 15/1364 72/8135 0.2166 0.4052 0.2959 FIS1/TBK1/GABARAPL1/GABARAPL2/PINK1/PRKN/OPTN/CSNK2B/USP8/UBB/TAX1BP1/KRAS/HIF1A/ATF4/NRAS 15 KEGG hsa00270 Cysteine and methionine metabolism 11/1364 51/8135 0.226 0.4195 0.3063 CBS/BHMT2/SDS/GOT1/DNMT1/SMS/MDH2/MPST/SRM/AHCY/MDH1 11 KEGG hsa04211 Longevity regulating pathway 18/1364 89/8135 0.2267 0.4195 0.3063 INSR/CREB3/PRKAG1/PRKAB1/PIK3CB/PPARG/CAT/ADCY1/NFKB1/KRAS/IGF1/ATF2/ATG13/CREB1/PIK3CD/ATF4/NRAS/PRKACB 18 KEGG hsa05418 Fluid shear stress and atherosclerosis 27/1364 139/8135 0.2288 0.4209 0.3074 GSTA4/MAP3K5/SDC1/GSTM4/NQO1/MGST3/PECAM1/PIK3CB/BMP4/MAPK7/ARHGEF2/CHUK/SELE/MAPK11/CDH5/TXN2/NFKB1/NOS3/GSTM5/PDGFB/ASS1/IFNG/GSTM3/KDR/VEGFA/RAC2/PIK3CD 27 KEGG hsa00562 Inositol phosphate metabolism 15/1364 73/8135 0.2332 0.4267 0.3116 PLCG2/MTMR4/MTMR6/SYNJ1/PIKFYVE/PIK3CB/PIK3C2B/PIK3C2G/PLCD1/PLCE1/ALDH6A1/MTMR1/ISYNA1/PIK3CD/PIK3C2A 15 KEGG hsa00100 Steroid biosynthesis 5/1364 20/8135 0.235 0.4276 0.3122 LBR/SC5D/DHCR7/DHCR24/LIPA 5 KEGG hsa01212 Fatty acid metabolism 12/1364 57/8135 0.2384 0.4314 0.315 ECHS1/TECR/MECR/ACSL5/HADH/HACD1/ACAT1/SCD5/SCP2/ACAA2/ACADVL/MCAT 12 KEGG hsa04216 Ferroptosis 9/1364 41/8135 0.2401 0.4322 0.3156 TFRC/SLC7A11/PRNP/ACSL5/GPX4/SLC39A8/FTL/SLC39A14/VDAC3 9 KEGG hsa04926 Relaxin signaling pathway 25/1364 129/8135 0.2434 0.4357 0.3181 NFKBIA/MAPK3/SOS1/EGFR/CREB3/GNG3/PIK3CB/ADCY1/ARRB1/MAPK11/GNG12/NFKB1/NOS3/KRAS/VEGFA/ATF2/MMP13/GNB2/CREB1/PIK3CD/COL3A1/ATF4/NRAS/PRKACB/RAF1 25 KEGG hsa05217 Basal cell carcinoma 13/1364 63/8135 0.2493 0.4439 0.3242 WNT5B/TCF7/GSK3B/BMP4/LEF1/WNT11/DDB2/FZD3/FZD6/FZD2/SMO/TCF7L2/CDKN1A 13 KEGG hsa04140 Autophagy - animal 27/1364 141/8135 0.2533 0.4487 0.3277 DDIT4/MAPK3/TBK1/GABARAPL1/GABARAPL2/MTMR4/CFLAR/UVRAG/BAD/DEPTOR/PIK3CB/RRAGA/RUBCN/SUPT20H/ATG2B/KRAS/HMGB1/ATG13/MLST8/PRKCQ/HIF1A/ATG4A/PIK3CD/NRAS/PRKACB/RAF1/TANK 27 KEGG hsa05417 Lipid and atherosclerosis 40/1364 215/8135 0.2579 0.4517 0.3298 NFKBIA/JAK2/MAP3K5/CCL5/MAPK3/TBK1/FAS/OLR1/BAD/GSK3B/RXRA/PIK3CB/CXCL2/ATF6/CD40/CHUK/PPARG/SELE/CASP9/IRF3/MAPK11/RAP1B/HSPA6/NFKB1/POU2F1/NOS3/APAF1/IRAK4/KRAS/TRAF3/IL6/PPP3CA/ERO1A/CXCL3/PIK3CD/CAMK2B/ATF4/CXCL8/NRAS/TANK 40 KEGG hsa00240 Pyrimidine metabolism 12/1364 58/8135 0.258 0.4517 0.3298 HDDC2/TK2/NME4/ENPP1/NME7/NT5C2/ENTPD4/DPYS/RRM2/NME3/TYMP/DCTD 12 KEGG hsa04920 Adipocytokine signaling pathway 14/1364 69/8135 0.2591 0.4517 0.3298 NFKBIA/TNFRSF1B/JAK2/G6PC3/PRKAG1/ACSL5/PRKAB1/RXRA/CHUK/NFKB1/AGRP/PCK2/PRKCQ/PCK1 14 KEGG hsa04936 Alcoholic liver disease 27/1364 142/8135 0.266 0.4614 0.3369 NFKBIA/ALDH7A1/MAP3K5/TBK1/FAS/TCF7/PRKAG1/PRKAB1/GSK3B/CXCL2/LEF1/CHUK/IL17RC/IRF3/MAPK11/NFKB1/IRAK4/SCD5/TRAF3/ALDH9A1/IL6/ALDH3A2/CXCL3/IL17RA/ACADVL/TCF7L2/CXCL8 27 KEGG hsa04929 GnRH secretion 13/1364 64/8135 0.2684 0.4618 0.3372 KCNN3/MAPK3/PRKCB/PIK3CB/ITPR2/ARRB1/GPER1/KRAS/KCNN2/CACNA1D/PIK3CD/NRAS/RAF1 13 KEGG hsa00770 Pantothenate and CoA biosynthesis 5/1364 21/8135 0.2691 0.4618 0.3372 ENPP1/DPYS/ALDH3A2/PANK3/VNN1 5 KEGG hsa05143 African trypanosomiasis 8/1364 37/8135 0.2729 0.4661 0.3403 FAS/PRKCB/APOL1/IDO1/SELE/HBB/IFNG/IL6 8 KEGG hsa04215 Apoptosis - multiple species 7/1364 32/8135 0.2828 0.4787 0.3495 BIRC3/BIRC2/BIRC7/CASP9/APAF1/NGFR/BIRC5 7 KEGG hsa04260 Cardiac muscle contraction 17/1364 87/8135 0.2832 0.4787 0.3495 ATP1B1/COX7A1/ATP2A3/UQCR10/CYC1/MYL3/COX6C/ASPH/COX8A/COX6A1/MYL4/COX5B/UQCRQ/RYR2/CACNB2/CACNA1D/CACNA2D3 17 KEGG hsa00062 Fatty acid elongation 6/1364 27/8135 0.2932 0.4906 0.3583 ECHS1/TECR/MECR/HADH/HACD1/ACAA2 6 KEGG hsa04966 Collecting duct acid secretion 6/1364 27/8135 0.2932 0.4906 0.3583 ATP6V0D1/ATP6V1F/SLC12A7/TCIRG1/ATP6V0E2/CA2 6 KEGG hsa04022 cGMP-PKG signaling pathway 31/1364 167/8135 0.2949 0.4911 0.3586 ADORA3/ATP1B1/ATP2A3/MAPK3/SLC25A4/INSR/GTF2IRD1/ROCK1/ATP2B2/BAD/CREB3/ITPR2/GUCY1A1/ADCY1/PPP1R12A/NPR2/PIK3R5/ATP2B1/GUCY1B1/NOS3/ADRB2/KCNMB2/ATF2/ATP2B4/PPP3CA/CREB1/VDAC3/KCNJ8/CACNA1D/ATF4/RAF1 31 KEGG hsa05030 Cocaine addiction 10/1364 49/8135 0.3002 0.4966 0.3626 SLC18A2/CREB3/TH/GRIA2/NFKB1/BDNF/ATF2/CREB1/ATF4/PRKACB 10 KEGG hsa00340 Histidine metabolism 5/1364 22/8135 0.3041 0.4966 0.3626 ALDH7A1/HDC/ALDH9A1/ALDH3A2/HNMT 5 KEGG hsa00900 Terpenoid backbone biosynthesis 5/1364 22/8135 0.3041 0.4966 0.3626 PMVK/ACAT1/DHDDS/HMGCS2/PDSS2 5 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 15/1364 77/8135 0.3042 0.4966 0.3626 SGCA/CDH2/SGCG/ATP2A3/SGCB/TCF7/ITGA5/LEF1/ITGB7/RYR2/CACNB2/ITGA4/CACNA1D/CACNA2D3/TCF7L2 15 KEGG hsa05130 Pathogenic Escherichia coli infection 36/1364 197/8135 0.3113 0.501 0.3658 NFKBIA/ACTR3B/MAPK3/ARPC1A/FAS/SEC24A/TUBB2B/ACTR3/BAIAP2/ROCK1/CLDN11/NCK2/CASP4/ARHGEF2/CHUK/F2R/CYFIP2/CASP9/WIPF1/TUBB6/MAPK11/ABI1/NFKB1/PAK2/ACTR2/IRAK4/TUBA4A/IL6/TLR5/NAIP/TMED10/CXCL8/ARPC5L/LPAR2/CTTN/TUBB2A 36 KEGG hsa03410 Base excision repair 7/1364 33/8135 0.3114 0.501 0.3658 PARP3/POLD2/TDG/POLD4/PARP4/MPG/HMGB1 7 KEGG hsa04130 SNARE interactions in vesicular transport 7/1364 33/8135 0.3114 0.501 0.3658 BNIP1/SEC22B/VTI1B/VAMP3/USE1/VAMP7/VAMP2 7 KEGG hsa00510 N-Glycan biosynthesis 10/1364 50/8135 0.3236 0.5181 0.3783 MGAT4C/B4GALT2/DPM3/DAD1/DPAGT1/FUT8/MAN1C1/MAN1B1/DDOST/ALG6 10 KEGG hsa00513 Various types of N-glycan biosynthesis 8/1364 39/8135 0.3258 0.5191 0.379 MGAT4C/B4GALT2/DAD1/HEXA/FUT8/MAN1C1/MAN1B1/DDOST 8 KEGG hsa05410 Hypertrophic cardiomyopathy 17/1364 90/8135 0.3352 0.5316 0.3882 SGCA/SGCG/ATP2A3/SGCB/ITGA5/PRKAG1/PRKAB1/MYL3/AGT/ITGB7/IGF1/IL6/RYR2/CACNB2/ITGA4/CACNA1D/CACNA2D3 17 KEGG hsa04964 Proximal tubule bicarbonate reclamation 5/1364 23/8135 0.3398 0.5362 0.3916 ATP1B1/PCK2/CA2/PCK1/MDH1 5 KEGG hsa04120 Ubiquitin mediated proteolysis 26/1364 142/8135 0.3432 0.5391 0.3937 BIRC3/UBE2D4/UBE2I/FBXW7/SKP1/TRIP12/BIRC2/SOCS1/UBE2J1/BIRC7/ELOB/HERC1/PRKN/DDB2/CBLB/UBB/ERCC8/UBE2E3/UBE2M/CUL2/CDC20/DET1/MID1/UBE3A/PML/UBR5 26 KEGG hsa05146 Amoebiasis 19/1364 102/8135 0.3456 0.5402 0.3945 LAMC3/PRKCB/PIK3CB/CXCL2/SERPINB6/ADCY1/LAMA5/NFKB1/HSPB1/CTSG/IFNG/IL6/CXCL3/GNA14/PIK3CD/ACTN1/COL3A1/CXCL8/PRKACB 19 KEGG hsa00511 Other glycan degradation 4/1364 18/8135 0.3565 0.5548 0.4051 FUCA1/HEXA/MAN2B2/NEU1 4 KEGG hsa04924 Renin secretion 13/1364 69/8135 0.3696 0.5697 0.416 PDE1A/KCNJ2/ITPR2/AGT/GUCY1A1/PTGER4/CLCA2/GUCY1B1/ADRB2/PPP3CA/CREB1/CACNA1D/PRKACB 13 KEGG hsa05031 Amphetamine addiction 13/1364 69/8135 0.3696 0.5697 0.416 SLC18A2/PRKCB/CREB3/TH/GRIA2/HDAC1/ATF2/PPP3CA/CREB1/CACNA1D/CAMK2B/ATF4/PRKACB 13 KEGG hsa00600 Sphingolipid metabolism 10/1364 52/8135 0.3715 0.5701 0.4163 SPHK1/CERS6/PLPP3/ASAH1/CERS4/HEXA/UGCG/CERS2/NEU1/PLPP1 10 KEGG hsa00564 Glycerophospholipid metabolism 18/1364 98/8135 0.3755 0.5736 0.4188 PNPLA6/AGPAT1/PEMT/AGPAT5/PLA2G15/PLA2G2D/DGKA/PLPP3/PLD3/PLA2G4C/PLD1/DGKZ/TAZ/PLA1A/ETNK2/LPGAT1/PLPP1/PTDSS1 18 KEGG hsa04024 cAMP signaling pathway 39/1364 221/8135 0.3892 0.5885 0.4297 NFKBIA/ATP1B1/FXYD1/SOX9/ATP2A3/MAPK3/ABCC4/ROCK1/ATP2B2/BAD/CREB3/PIK3CB/PDE4B/F2R/PLD1/ADCY1/GRIA2/PPP1R12A/GHSR/RAP1B/ATP2B1/NFKB1/ARAP3/EP300/ADRB2/BDNF/NPY1R/RAC2/PLCE1/ATP2B4/RYR2/CREB1/CACNA1D/CRHR2/PIK3CD/CAMK2B/SSTR5/PRKACB/RAF1 39 KEGG hsa00030 Pentose phosphate pathway 6/1364 30/8135 0.3893 0.5885 0.4297 RBKS/PGM1/PRPS2/PFKM/PRPS1/ALDOC 6 KEGG hsa04622 RIG-I-like receptor signaling pathway 13/1364 70/8135 0.3905 0.5885 0.4297 RNF125/NFKBIA/CXCL10/TBK1/CHUK/IRF3/MAPK11/NFKB1/CYLD/TRAF3/PIN1/CXCL8/TANK 13 KEGG hsa00531 Glycosaminoglycan degradation 4/1364 19/8135 0.3977 0.594 0.4337 GUSB/NAGLU/HEXA/ARSB 4 KEGG hsa00350 Tyrosine metabolism 7/1364 36/8135 0.3996 0.594 0.4337 FAH/HPD/GOT1/COMT/TH/GSTZ1/DCT 7 KEGG hsa00760 Nicotinate and nicotinamide metabolism 7/1364 36/8135 0.3996 0.594 0.4337 ENPP1/NT5C2/CD38/SIRT3/PNP/NADSYN1/NAMPT 7 KEGG hsa04350 TGF-beta signaling pathway 17/1364 94/8135 0.4075 0.6031 0.4404 MAPK3/SKP1/SMAD3/ZFYVE16/ROCK1/NEO1/BMP4/GDF5/ID4/EP300/IFNG/MYC/TGIF2/NBL1/ID3/INHBB/SMAD1 17 KEGG hsa00410 beta-Alanine metabolism 6/1364 31/8135 0.4216 0.6157 0.4496 ALDH7A1/ECHS1/DPYS/ALDH9A1/ALDH6A1/ALDH3A2 6 KEGG hsa04710 Circadian rhythm 6/1364 31/8135 0.4216 0.6157 0.4496 SKP1/RORA/PRKAG1/PRKAB1/CREB1/CRY1 6 KEGG hsa05310 Asthma 6/1364 31/8135 0.4216 0.6157 0.4496 MS4A2/FCER1A/HLA-DQB1/CD40/HLA-DOB/HLA-DQA1 6 KEGG hsa04730 Long-term depression 11/1364 60/8135 0.4248 0.6177 0.4511 MAPK3/PRKCB/ITPR2/GUCY1A1/PLA2G4C/GRIA2/GUCY1B1/KRAS/IGF1/NRAS/RAF1 11 KEGG hsa00590 Arachidonic acid metabolism 11/1364 61/8135 0.4479 0.6483 0.4734 HPGDS/LTC4S/PTGS1/TBXAS1/PLA2G2D/EPHX2/GPX3/PTGDS/PLA2G4C/GPX1/AKR1C3 11 KEGG hsa00010 Glycolysis / Gluconeogenesis 12/1364 67/8135 0.451 0.6483 0.4734 ALDH7A1/G6PC3/PGM1/ENO2/DLD/PFKM/PCK2/ALDH9A1/ALDH3A2/PCK1/PDHB/ALDOC 12 KEGG hsa00640 Propanoate metabolism 6/1364 32/8135 0.4536 0.6483 0.4734 ECHS1/BCKDHB/PCCB/DLD/ALDH6A1/SUCLG1 6 KEGG hsa04136 Autophagy - other 6/1364 32/8135 0.4536 0.6483 0.4734 GABARAPL1/GABARAPL2/ATG2B/ATG13/MLST8/ATG4A 6 KEGG hsa03018 RNA degradation 14/1364 79/8135 0.4563 0.6494 0.4742 WDR61/LSM4/EXOSC7/ENO2/PABPC3/LSM3/DCP2/PFKM/EDC4/LSM5/PABPC1/CNOT9/EXOSC5/LSM7 14 KEGG hsa04610 Complement and coagulation cascades 15/1364 85/8135 0.4586 0.6498 0.4745 C7/PROS1/CLU/SERPINA1/SERPINA5/SERPINE1/ITGAX/CFD/CFI/TFPI/F2R/F8/CR1/MBL2/C4BPB 15 KEGG hsa04070 Phosphatidylinositol signaling system 17/1364 97/8135 0.4625 0.6526 0.4765 PLCG2/PRKCB/MTMR4/MTMR6/SYNJ1/PIKFYVE/DGKA/PIK3CB/ITPR2/PIK3C2B/DGKZ/PIK3C2G/PLCD1/PLCE1/MTMR1/PIK3CD/PIK3C2A 17 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 3/1364 15/8135 0.4721 0.6606 0.4824 HEXA/ST3GAL2/ST3GAL1 3 KEGG hsa00730 Thiamine metabolism 3/1364 15/8135 0.4721 0.6606 0.4824 THTPA/AK1/ACP1 3 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 17/1364 98/8135 0.4808 0.6699 0.4891 PLCG2/PRKCB/PRKCH/PIK3CB/ITPR2/HTR2B/PTGER4/PLA2G4C/ADCY1/MAPK11/NTRK1/IGF1/PRKCQ/TRPV2/PIK3CD/CAMK2B/PRKACB 17 KEGG hsa01230 Biosynthesis of amino acids 13/1364 75/8135 0.4957 0.6878 0.5022 CBS/SDS/GOT1/ENO2/PC/PRPS2/PFKM/CPS1/ASS1/PRPS1/ALDOC/ALDH18A1/PYCR1 13 KEGG hsa00040 Pentose and glucuronate interconversions 6/1364 34/8135 0.5162 0.7113 0.5194 AKR1B1/CRYL1/AKR1B10/GUSB/SORD/UGT2B17 6 KEGG hsa00220 Arginine biosynthesis 4/1364 22/8135 0.5169 0.7113 0.5194 GOT1/NOS3/CPS1/ASS1 4 KEGG hsa04922 Glucagon signaling pathway 18/1364 107/8135 0.5345 0.7323 0.5348 G6PC3/CREB3/PRKAG1/PRKAB1/ITPR2/PYGM/PPP4R3A/PFKM/EP300/PCK2/ATF2/PPP3CA/CREB1/PCK1/PDHB/CAMK2B/ATF4/PRKACB 18 KEGG hsa04927 Cortisol synthesis and secretion 11/1364 65/8135 0.5384 0.7323 0.5348 CREB3/KCNK3/CYP11A1/ITPR2/AGT/ADCY1/ATF2/CREB1/CACNA1D/ATF4/PRKACB 11 KEGG hsa00514 Other types of O-glycan biosynthesis 8/1364 47/8135 0.5421 0.7323 0.5348 GALNT11/EOGT/B4GALT2/RFNG/GALNT10/POFUT1/GALNT3/OGT 8 KEGG hsa04973 Carbohydrate digestion and absorption 8/1364 47/8135 0.5421 0.7323 0.5348 ATP1B1/PRKCB/G6PC3/PIK3CB/SLC2A5/LCT/CACNA1D/PIK3CD 8 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 25/1364 150/8135 0.5478 0.7323 0.5348 SCN1B/ATP1B1/ATP2A3/MAPK3/KCNQ1/ATP2B2/CREB3/MYL3/AGT/ADCY1/MAPK11/PIK3R5/ATP2B1/MYL4/ADRB2/ATF2/ATP2B4/RYR2/CREB1/CACNB2/CACNA1D/CACNA2D3/CAMK2B/ATF4/PRKACB 25 KEGG hsa04915 Estrogen signaling pathway 23/1364 138/8135 0.5487 0.7323 0.5348 MAPK3/NCOA3/SOS1/EGFR/CREB3/KRT10/PIK3CB/ITPR2/KRT14/ADCY1/HSPA6/GPER1/NOS3/HBEGF/KRAS/ATF2/CREB1/KRT33A/PIK3CD/ATF4/NRAS/PRKACB/RAF1 23 KEGG hsa04972 Pancreatic secretion 17/1364 102/8135 0.5526 0.7323 0.5348 ATP1B1/CPA3/ATP2A3/KCNQ1/PRKCB/PLA2G2D/CD38/ATP2B2/ITPR2/ADCY1/CLCA2/RAP1B/ATP2B1/CCKAR/ATP2B4/CA2/RYR2 17 KEGG hsa05414 Dilated cardiomyopathy 16/1364 96/8135 0.5535 0.7323 0.5348 SGCA/SGCG/ATP2A3/SGCB/ITGA5/MYL3/AGT/ADCY1/ITGB7/IGF1/RYR2/CACNB2/ITGA4/CACNA1D/CACNA2D3/PRKACB 16 KEGG hsa03060 Protein export 4/1364 23/8135 0.5542 0.7323 0.5348 SEC11A/SPCS3/SEC61A2/SRP54 4 KEGG hsa03430 Mismatch repair 4/1364 23/8135 0.5542 0.7323 0.5348 POLD2/RPA1/POLD4/RPA3 4 KEGG hsa00450 Selenocompound metabolism 3/1364 17/8135 0.5611 0.7356 0.5371 PAPSS1/SEPHS1/TXNRD2 3 KEGG hsa00910 Nitrogen metabolism 3/1364 17/8135 0.5611 0.7356 0.5371 CA12/CPS1/CA2 3 KEGG hsa03460 Fanconi anemia pathway 9/1364 54/8135 0.5647 0.7375 0.5385 ERCC1/ATR/FANCI/RMI1/RPA1/RPA3/BRCA2/RAD51C/HES1 9 KEGG hsa00512 Mucin type O-glycan biosynthesis 6/1364 36/8135 0.5758 0.749 0.5469 GALNT11/ST3GAL2/GALNT10/GCNT3/ST3GAL1/GALNT3 6 KEGG hsa00053 Ascorbate and aldarate metabolism 5/1364 30/8135 0.5817 0.7538 0.5504 ALDH7A1/GUSB/UGT2B17/ALDH9A1/ALDH3A2 5 KEGG hsa00140 Steroid hormone biosynthesis 10/1364 61/8135 0.5847 0.7547 0.5511 HSD11B2/COMT/HSD17B1/CYP11A1/CYP7B1/STS/UGT2B17/AKR1C3/AKR1C4/SULT1E1 10 KEGG hsa04217 Necroptosis 26/1364 159/8135 0.5897 0.7555 0.5517 TNFAIP3/JAK2/STAT1/BIRC3/SLC25A4/FAS/TRAF5/CFLAR/BIRC2/TYK2/JAK1/CHMP1B/PYGM/PLA2G4C/CHMP6/STAT4/CYLD/IFNG/HMGB1/CHMP2A/FTL/STAT5A/USP21/VDAC3/CAMK2B/AIFM1 26 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/1364 24/8135 0.5899 0.7555 0.5517 EXT2/EXTL2/B4GALT7/EXTL1 4 KEGG hsa00061 Fatty acid biosynthesis 3/1364 18/8135 0.602 0.7681 0.5608 MECR/ACSL5/MCAT 3 KEGG hsa04918 Thyroid hormone synthesis 12/1364 75/8135 0.619 0.7867 0.5745 ATP1B1/PRKCB/CREB3/GPX3/ITPR2/ADCY1/GPX1/ATF2/CREB1/ASGR1/ATF4/PRKACB 12 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 11/1364 69/8135 0.6232 0.789 0.5762 HPGDS/GSTA4/EPHX1/GSTM4/MGST3/GSTM5/NAT2/GSTM3/UGT2B17/SULT1A2/CYP3A43 11 KEGG hsa04512 ECM-receptor interaction 14/1364 88/8135 0.6301 0.7948 0.5804 LAMC3/THBS4/SDC1/ITGA5/CD44/CHAD/HMMR/LAMA5/ITGB7/COMP/THBS2/COL6A3/SV2B/ITGA4 14 KEGG hsa04913 Ovarian steroidogenesis 8/1364 51/8135 0.6401 0.8002 0.5843 INSR/HSD17B1/CYP11A1/PLA2G4C/ADCY1/IGF1/AKR1C3/PRKACB 8 KEGG hsa04728 Dopaminergic synapse 21/1364 132/8135 0.6411 0.8002 0.5843 SLC18A2/PRKCB/CREB3/COMT/GNG3/GSK3B/TH/ITPR2/GRIA2/ARRB1/MAPK11/GNG12/ATF2/KIF5C/PPP3CA/GNB2/CREB1/CACNA1D/CAMK2B/ATF4/PRKACB 21 KEGG hsa04530 Tight junction 27/1364 169/8135 0.6416 0.8002 0.5843 ACTR3B/MAP3K5/MYL6B/ARPC1A/MICALL2/ACTR3/ROCK1/RAP2C/CLDN11/PRKAG1/PRKAB1/CDK4/ERBB2/ARHGEF2/RAB13/RAPGEF6/PRKCI/ACTR2/TUBA4A/LLGL2/CACNA1D/ACTN1/AMOTL2/TJP2/ARPC5L/PRKACB/CTTN 27 KEGG hsa04670 Leukocyte transendothelial migration 18/1364 114/8135 0.6496 0.8072 0.5894 PLCG2/PRKCB/ITK/ROCK1/CLDN11/ITGAL/PECAM1/PIK3CB/MAPK11/CDH5/RAP1B/CXCR4/ARHGAP35/RAC2/TXK/ITGA4/PIK3CD/ACTN1 18 KEGG hsa04914 Progesterone-mediated oocyte maturation 16/1364 102/8135 0.6566 0.8128 0.5935 CDC25B/MAPK3/STK10/CCNA2/PIK3CB/ADCY1/MAPK11/KRAS/CCNB2/IGF1/RPS6KA3/CCNB1/PIK3CD/PRKACB/RAF1/RPS6KA1 16 KEGG hsa05171 Coronavirus disease - COVID-19 37/1364 232/8135 0.66 0.8139 0.5943 NFKBIA/CXCL10/C7/STAT1/ADAM17/ADAR/MAPK3/PLCG2/TBK1/PRKCB/EGFR/RPS8/RPS12/TYK2/JAK1/CFD/PIK3CB/RPL12/CHUK/IRF3/MAPK11/NFKB1/HBEGF/RPS5/RPL10A/RPS11/IRAK4/MBL2/IL6R/TRAF3/IL6/RPL8/PIK3CD/RPL19/CXCL8/RPL27A/TLR8 37 KEGG hsa03050 Proteasome 7/1364 46/8135 0.6717 0.8223 0.6005 PSMB9/PSMC2/PSMC3/IFNG/PSMB5/PSMB6/PSMD8 7 KEGG hsa04930 Type II diabetes mellitus 7/1364 46/8135 0.6717 0.8223 0.6005 MAPK3/INSR/SOCS1/PIK3CB/ABCC8/CACNA1D/PIK3CD 7 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 3/1364 20/8135 0.6759 0.8245 0.602 UST/CHST15/B4GALT7 3 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 8/1364 53/8135 0.6844 0.8279 0.6045 ATP1B1/PTH1R/PRKCB/ATP2B2/AP2M1/ATP2B1/ATP2B4/PRKACB 8 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/1364 27/8135 0.6862 0.8279 0.6045 B4GALT2/FUT1/B3GALNT1/FUT4 4 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 4/1364 27/8135 0.6862 0.8279 0.6045 TECR/HACD1/SCD5/SCP2 4 KEGG hsa05017 Spinocerebellar ataxia 22/1364 143/8135 0.7062 0.849 0.6199 MAP3K5/ATP2A3/SLC25A4/PRKCB/RORA/FGF14/PUM2/ATXN10/RBPJ/PIK3CB/ITPR2/GRIA2/PSMC2/ATG2B/PSMC3/PSMB5/PSMB6/ATG13/KAT5/VDAC3/PSMD8/PIK3CD 22 KEGG hsa04970 Salivary secretion 14/1364 93/8135 0.7135 0.8547 0.6241 ATP1B1/PRKCB/CD38/ATP2B2/ITPR2/GUCY1A1/ADCY1/ATP2B1/GUCY1B1/ADRB2/ATP2B4/VAMP2/PRKACB/CAMP 14 KEGG hsa04371 Apelin signaling pathway 21/1364 139/8135 0.735 0.8684 0.6341 SPHK1/MAPK3/SMAD3/SERPINE1/PRKAG1/GNG3/PRKAB1/EGR1/ITPR2/MYL3/ADCY1/PIK3R5/GNG12/NOS3/MYL4/KRAS/GNB2/RYR2/NRAS/PRKACB/RAF1 21 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 7/1364 49/8135 0.7366 0.8684 0.6341 CYB5R1/GNPDA1/MPI/PGM1/HEXA/GMDS/PMM1 7 KEGG hsa00565 Ether lipid metabolism 7/1364 49/8135 0.7366 0.8684 0.6341 PLA2G2D/PLPP3/PLD3/PLA2G7/PLA2G4C/PLD1/PLPP1 7 KEGG hsa04724 Glutamatergic synapse 17/1364 114/8135 0.7403 0.8684 0.6341 MAPK3/PRKCB/SLC38A2/GNG3/ITPR2/PLA2G4C/PLD1/ADCY1/GRIA2/SLC38A1/GNG12/HOMER2/PPP3CA/HOMER3/GNB2/CACNA1D/PRKACB 17 KEGG hsa04923 Regulation of lipolysis in adipocytes 8/1364 56/8135 0.7441 0.8684 0.6341 PTGS1/INSR/PIK3CB/ADCY1/ADRB2/NPY1R/PIK3CD/PRKACB 8 KEGG hsa00500 Starch and sucrose metabolism 5/1364 36/8135 0.745 0.8684 0.6341 ENPP1/G6PC3/PGM1/PYGM/GAA 5 KEGG hsa03030 DNA replication 5/1364 36/8135 0.745 0.8684 0.6341 POLD2/DNA2/RPA1/POLD4/RPA3 5 KEGG hsa04727 GABAergic synapse 13/1364 89/8135 0.75 0.8684 0.6341 GABARAPL1/GABARAPL2/PRKCB/SLC38A2/GABRB1/GNG3/GABRA4/ADCY1/SLC38A1/GNG12/GNB2/CACNA1D/PRKACB 13 KEGG hsa00860 Porphyrin metabolism 6/1364 43/8135 0.7503 0.8684 0.6341 GUSB/FECH/UROD/UROS/UGT2B17/CPOX 6 KEGG hsa04726 Serotonergic synapse 17/1364 115/8135 0.7534 0.8684 0.6341 PTGS1/SLC18A2/MAPK3/PRKCB/GABRB1/GNG3/ITPR2/HTR2B/PLA2G4C/GNG12/KRAS/GNB2/KCNN2/CACNA1D/NRAS/PRKACB/RAF1 17 KEGG hsa03040 Spliceosome 22/1364 147/8135 0.7546 0.8684 0.6341 SNRNP40/LSM4/THOC2/SF3B1/THOC1/SNU13/HNRNPK/TCERG1/LSM3/DDX46/DDX23/HSPA6/SF3B5/LSM5/SRSF8/PPIE/SNRPD2/SRSF4/HNRNPA1/TXNL4A/LSM7/BUD31 22 KEGG hsa05150 Staphylococcus aureus infection 14/1364 96/8135 0.7576 0.8684 0.6341 HLA-DQB1/ITGAL/KRT10/CFD/CFI/KRT14/DEFA6/MBL2/HLA-DOB/KRT33A/FCGR2B/HLA-DQA1/DEFA5/CAMP 14 KEGG hsa03008 Ribosome biogenesis in eukaryotes 16/1364 109/8135 0.7589 0.8684 0.6341 RBM28/UTP6/NXF3/NHP2/SNU13/HEATR1/NMD3/WDR43/CSNK2B/AK6/NXF1/POP7/MDN1/EIF6/GNL3L/BMS1 16 KEGG hsa00515 Mannose type O-glycan biosynthesis 3/1364 23/8135 0.7669 0.8717 0.6365 B4GALT2/B4GAT1/FUT4 3 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 5/1364 37/8135 0.767 0.8717 0.6365 GOT1/DDO/ASRGL1/CPS1/ASS1 5 KEGG hsa04713 Circadian entrainment 14/1364 97/8135 0.7712 0.8725 0.6371 MAPK3/PRKCB/GNG3/GUCY1A1/ADCY1/GRIA2/GUCY1B1/GNG12/GNB2/RYR2/CREB1/CACNA1D/CAMK2B/PRKACB 14 KEGG hsa00360 Phenylalanine metabolism 2/1364 16/8135 0.7762 0.8725 0.6371 HPD/GOT1 2 KEGG hsa00430 Taurine and hypotaurine metabolism 2/1364 16/8135 0.7762 0.8725 0.6371 FMO4/FMO3 2 KEGG hsa05032 Morphine addiction 13/1364 91/8135 0.7782 0.8725 0.6371 PRKCB/GABRB1/PDE1A/GNG3/GABRA4/PDE4B/ADCY1/ARRB1/GNG12/GNB2/GRK6/PDE11A/PRKACB 13 KEGG hsa04114 Oocyte meiosis 19/1364 131/8135 0.7906 0.8835 0.6451 AR/MAPK3/SKP1/PTTG1/ITPR2/ADCY1/MAPK11/YWHAH/CCNB2/IGF1/CDC20/RPS6KA3/CCNB1/PPP3CA/SMC1A/CAMK2B/PTTG2/PRKACB/RPS6KA1 19 KEGG hsa04152 AMPK signaling pathway 17/1364 120/8135 0.8122 0.9046 0.6605 CCNA2/INSR/G6PC3/CREB3/PRKAG1/PRKAB1/PIK3CB/PFKFB3/PPARG/PFKM/SCD5/IGF1/PCK2/CREB1/RAB11B/PCK1/PIK3CD 17 KEGG hsa04270 Vascular smooth muscle contraction 19/1364 134/8135 0.8218 0.9121 0.6661 MYL6B/MAPK3/PRKCB/PLA2G2D/ROCK1/PRKCH/ITPR2/AGT/GUCY1A1/PLA2G4C/ADCY1/PPP1R12A/NPR2/GUCY1B1/KCNMB2/PRKCQ/CACNA1D/PRKACB/RAF1 19 KEGG hsa05133 Pertussis 10/1364 76/8135 0.8418 0.9313 0.6801 IRF1/MAPK3/ITGA5/IRF3/MAPK11/NFKB1/IRAK4/IL6/C4BPB/CXCL8 10 KEGG hsa04340 Hedgehog signaling pathway 7/1364 56/8135 0.8515 0.9347 0.6825 GAS1/SCUBE2/GSK3B/ARRB1/CSNK1A1/SMO/PRKACB 7 KEGG hsa04390 Hippo signaling pathway 22/1364 157/8135 0.8517 0.9347 0.6825 WNT5B/BIRC3/SMAD3/BIRC2/TCF7/SERPINE1/GSK3B/TP53BP2/BMP4/LEF1/WNT11/GDF5/FZD3/PRKCI/YWHAH/MYC/FZD6/LLGL2/BIRC5/FZD2/SMAD1/TCF7L2 22 KEGG hsa05100 Bacterial invasion of epithelial cells 10/1364 77/8135 0.8533 0.9347 0.6825 ACTR3B/ARPC1A/ACTR3/ITGA5/PIK3CB/ACTR2/PIK3CD/ARPC5L/CTTN/CD2AP 10 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 10/1364 78/8135 0.864 0.9434 0.6888 HPGDS/GSTA4/EPHX1/AKR7A3/GSTM4/MGST3/AKR7A2/GSTM5/GSTM3/UGT2B17 10 KEGG hsa04975 Fat digestion and absorption 5/1364 43/8135 0.8697 0.9464 0.6911 AGPAT1/PLA2G2D/PLPP3/ACAT1/PLPP1 5 KEGG hsa00982 Drug metabolism - cytochrome P450 9/1364 72/8135 0.8739 0.948 0.6922 HPGDS/GSTA4/GSTM4/MGST3/GSTM5/FMO4/GSTM3/UGT2B17/FMO3 9 KEGG hsa01250 Biosynthesis of nucleotide sugars 4/1364 37/8135 0.8892 0.9614 0.702 MPI/PGM1/GMDS/PMM1 4 KEGG hsa04976 Bile secretion 11/1364 89/8135 0.9006 0.9706 0.7087 EPHX1/ATP1B1/ABCC4/SLC27A5/RXRA/ADCY1/UGT2B17/CA2/KCNN2/PRKACB/ABCB1 11 KEGG hsa04971 Gastric acid secretion 9/1364 76/8135 0.9098 0.9773 0.7137 ATP1B1/KCNQ1/PRKCB/KCNJ2/ITPR2/ADCY1/CA2/CAMK2B/PRKACB 9 KEGG hsa00592 alpha-Linolenic acid metabolism 2/1364 25/8135 0.9389 1 0.7302 PLA2G2D/PLA2G4C 2 KEGG hsa04978 Mineral absorption 6/1364 60/8135 0.9514 1 0.7302 ATP1B1/ATP2B2/ATP2B1/CYBRD1/FTL/ATP2B4 6 KEGG hsa04721 Synaptic vesicle cycle 8/1364 78/8135 0.9625 1 0.7302 SLC18A2/ATP6V0D1/ATP6V1F/AP2M1/TCIRG1/ATP6V0E2/VAMP2/NAPA 8 KEGG hsa05206 MicroRNAs in cancer 41/1364 310/8135 0.9655 1 0.7302 CDC25B/NOTCH1/DDIT4/UBE2I/MAPK3/PLCG2/ATM/PRKCB/SOS1/DNMT1/EZH2/ITGA5/SOCS1/EGFR/ROCK1/NOTCH4/PIM1/EFNA5/ERBB2/HNRNPK/PIK3CB/MAPK7/CD44/FZD3/NFKB1/ABCC1/EP300/ZFPM2/PDGFB/HDAC1/KRAS/MYC/VEGFA/MCL1/PIK3CD/CDKN1A/NRAS/HOXD10/RAF1/ABCB1/E2F3 41 KEGG hsa00591 Linoleic acid metabolism 2/1364 29/8135 0.9668 1 0.7302 PLA2G2D/PLA2G4C 2 KEGG hsa01210 2-Oxocarboxylic acid metabolism 1/1364 19/8135 0.9695 1 0.7302 GOT1 1 KEGG hsa05033 Nicotine addiction 3/1364 40/8135 0.9739 1 0.7302 GABRB1/GABRA4/GRIA2 3 KEGG hsa00670 One carbon pool by folate 1/1364 20/8135 0.9747 1 0.7302 MTHFD2 1 KEGG hsa00830 Retinol metabolism 6/1364 68/8135 0.9802 1 0.7302 PNPLA4/DHRS9/ALDH1A1/DHRS3/UGT2B17/ALDH1A3 6 KEGG hsa05168 Herpes simplex virus 1 infection 67/1364 495/8135 0.9817 1 0.7302 NFKBIA/TAP1/SRPK1/JAK2/ZNF267/HLA-C/STAT1/BIRC3/CCL5/ZNF611/TBK1/FAS/HLA-G/HLA-F/HLA-A/TRAF5/BIRC2/NXF3/ITGA5/BAD/HLA-DQB1/ZNF721/ZNF160/HLA-E/HLA-B/NECTIN2/HCFC2/TYK2/TNFRSF14/JAK1/PIK3CB/CHUK/ZNF430/CASP9/IRF3/TAPBP/ZNF343/NXF1/NFKB1/POU2F1/ZNF226/APAF1/IRAK4/IFNG/ZNF562/DAXX/ZNF132/TRAF3/IL6/ZNF552/HLA-DOB/SRSF8/ZNF93/TAP2/PML/ZNF415/ZNF549/TNFSF14/CFP/ZNF222/HLA-DQA1/SRSF4/PIK3CD/ZNF667/ZFP37/ZNF84/ZNF587 67 KEGG hsa04977 Vitamin digestion and absorption 1/1364 24/8135 0.9879 1 0.7302 ABCC1 1 KEGG hsa04613 Neutrophil extracellular trap formation 21/1364 190/8135 0.9902 1 0.7302 MAPK3/PLCG2/SLC25A4/PRKCB/ITGAL/ELANE/CASP4/PIK3CB/MAPK11/CR1/NFKB1/CTSG/HDAC1/HMGB1/RAC2/GSDMD/VDAC3/PIK3CD/CAMP/TLR8/RAF1 21 KEGG hsa04950 Maturity onset diabetes of the young 1/1364 26/8135 0.9916 1 0.7302 HES1 1 KEGG hsa03010 Ribosome 16/1364 158/8135 0.9938 1 0.7302 RPS8/RPS12/RPL12/MRPL24/MRPL11/RPS5/RPL10A/RPS11/MRPS17/MRPL4/MRPL23/RPL8/MRPS11/RPL19/MRPL18/RPL27A 16 KEGG hsa04744 Phototransduction 1/1364 29/8135 0.9952 1 0.7302 GUCA1A 1 KEGG hsa03015 mRNA surveillance pathway 8/1364 97/8135 0.9952 1 0.7302 NXF3/RNGTT/PABPC3/NXF1/CPSF7/TARDBP/PABPC1/PAPOLG 8 KEGG hsa05034 Alcoholism 19/1364 187/8135 0.9964 1 0.7302 SLC18A2/MAPK3/SOS1/SLC29A1/CREB3/NTRK2/GNG3/TH/GNG12/HDAC1/KRAS/BDNF/ATF2/GNB2/CREB1/ATF4/NRAS/PRKACB/RAF1 19 KEGG hsa04974 Protein digestion and absorption 8/1364 103/8135 0.9976 1 0.7302 ATP1B1/CPA3/KCNQ1/SLC38A2/COL15A1/COL6A3/COL3A1/COL5A3 8 KEGG hsa04742 Taste transduction 6/1364 86/8135 0.9978 1 0.7302 PDE1A/GABRA4/TAS2R3/PKD2L1/SCN9A/PRKACB 6 KEGG hsa05322 Systemic lupus erythematosus 11/1364 136/8135 0.999 1 0.7302 C7/HLA-DQB1/ELANE/CD40/TRIM21/CD28/CTSG/IFNG/HLA-DOB/HLA-DQA1/ACTN1 11 KEGG hsa04080 Neuroactive ligand-receptor interaction 38/1364 353/8135 0.9996 1 0.7302 ADORA3/TACR2/PTH1R/GABRB1/GABRA4/PENK/AGT/S1PR1/HTR2B/HRH3/PTGER4/F2R/GRIA2/PTGFR/GZMA/VIPR1/GHSR/CHRNB1/TSPO/HCRT/CTSG/CALCR/ADRB2/CHRNA3/CCKAR/NPY1R/HCRTR2/P2RX4/GHR/GAL/NMBR/OPRL1/CRHR2/TAC1/GALR3/NMB/SSTR5/LPAR2 38 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/1364 66/8135 1 1 0.7302 GATB 1 KEGG hsa04740 Olfactory transduction 10/1364 440/8135 1 1 0.7302 PDE1A/OR10H1/OR12D2/OR7A17/ARRB1/OR1F1/CAMK2B/OR3A1/PRKACB/ANO2 10