ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04142 Lysosome 18/384 132/8135 4.398e-05 0.01372 0.0132 ABCB9/GNS/DNASE2/CTNS/LIPA/ATP6V0B/ACP2/ATP6V0D1/ATP6AP1/NEU1/AP3D1/GUSB/MCOLN1/MANBA/MAN2B1/TPP1/GM2A/HYAL4 18 KEGG hsa03030 DNA replication 7/384 36/8135 0.001257 0.1501 0.1444 RNASEH2A/MCM2/MCM5/POLD1/MCM7/POLE4/POLA2 7 KEGG hsa05162 Measles 15/384 139/8135 0.002261 0.1501 0.1444 IL2RA/IFNAR1/HSPA2/CD28/CD209/GSK3B/IFNAR2/CASP3/CCND1/MAPK8/CD46/CSNK2B/IRAK1/IL1B/NFKBIB 15 KEGG hsa04110 Cell cycle 14/384 126/8135 0.002386 0.1501 0.1444 ANAPC1/MCM2/MCM5/GSK3B/MCM7/CCND1/YWHAQ/CDC25A/STAG2/E2F1/E2F4/MAD2L2/PLK1/E2F2 14 KEGG hsa00030 Pentose phosphate pathway 6/384 30/8135 0.002406 0.1501 0.1444 PGLS/G6PD/GLYCTK/TKTL1/TKT/GPI 6 KEGG hsa01200 Carbon metabolism 13/384 115/8135 0.002896 0.1506 0.1448 GOT1/PGLS/G6PD/GLYCTK/IDH2/GOT2/SDSL/TKTL1/TKT/GPI/ADPGK/CAT/SHMT1 13 KEGG hsa00480 Glutathione metabolism 8/384 58/8135 0.005538 0.2021 0.1944 G6PD/RRM2B/ODC1/GSS/IDH2/GPX1/OPLAH/SRM 8 KEGG hsa01240 Biosynthesis of cofactors 15/384 153/8135 0.005646 0.2021 0.1944 ALPL/UGT2B7/TDO2/PDXP/COASY/UGT2B17/GSS/CAD/QPRT/AK1/GUSB/NADSYN1/COX15/SHMT1/UGDH 15 KEGG hsa05418 Fluid shear stress and atherosclerosis 14/384 139/8135 0.005831 0.2021 0.1944 BMPR1A/DUSP1/ACVR1/CAV2/MAPK13/HMOX1/TXN2/ITGAV/CALM2/MAPK8/BMPR1B/CALM1/PLAT/IL1B 14 KEGG hsa04728 Dopaminergic synapse 13/384 132/8135 0.009297 0.2901 0.2789 GNGT2/ARRB1/KCNJ5/MAPK13/DRD5/PPP2CB/GSK3B/CALM2/ITPR3/GNG4/MAPK8/CALM1/CREB5 13 KEGG hsa05152 Tuberculosis 16/384 180/8135 0.01089 0.3088 0.2969 IRAK2/CD209/MAPK13/ATP6V0B/RFXANK/ATP6V0D1/CASP3/SPHK2/CALM2/ATP6AP1/MAPK8/MALT1/CALM1/IRAK1/IL1B/FCGR1A 16 KEGG hsa04144 Endocytosis 20/384 251/8135 0.01501 0.3902 0.3752 IL2RA/DNM2/ARRB1/CHMP7/CAV2/EPN1/VPS26B/HSPA2/RAB22A/AP2A2/AP2M1/CAPZB/EPS15L1/CHMP1B/PSD4/SNX4/ARPC4/TSG101/AP2S1/WASL 20 KEGG hsa04114 Oocyte meiosis 12/384 131/8135 0.02066 0.4146 0.3987 ANAPC1/RPS6KA1/MAPK13/PPP2CB/YWHAQ/CALM2/ITPR3/CALM1/MAD2L2/PLK1/STAG3/SLK 12 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 16/384 194/8135 0.02092 0.4146 0.3987 GNGT2/IFNAR1/MAPK13/GSK3B/IFNAR2/CASP3/CCND1/CALM2/ITPR3/GNG4/MAPK8/CALM1/PREX1/E2F1/CSF2/E2F2 16 KEGG hsa01230 Biosynthesis of amino acids 8/384 75/8135 0.02444 0.4146 0.3987 GOT1/ASNS/IDH2/GOT2/SDSL/TKTL1/TKT/SHMT1 8 KEGG hsa04722 Neurotrophin signaling pathway 11/384 119/8135 0.02458 0.4146 0.3987 ARHGDIA/RPS6KA1/IRAK2/MAPK13/GSK3B/CALM2/MAPK8/CALM1/IRAK1/NFKBIB/IRAK3 11 KEGG hsa00760 Nicotinate and nicotinamide metabolism 5/384 36/8135 0.02578 0.4146 0.3987 BST1/NT5E/QPRT/NADSYN1/SIRT7 5 KEGG hsa05133 Pertussis 8/384 76/8135 0.02624 0.4146 0.3987 MAPK13/CASP3/CALM2/MAPK8/C4BPB/CALM1/IRAK1/IL1B 8 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 6/384 49/8135 0.02677 0.4146 0.3987 GNPDA2/AMDHD2/GNPDA1/GNE/GPI/UGDH 6 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 5/384 37/8135 0.0287 0.4146 0.3987 GOT1/ASNS/PPAT/CAD/GOT2 5 KEGG hsa04721 Synaptic vesicle cycle 8/384 78/8135 0.0301 0.4146 0.3987 DNM2/AP2A2/AP2M1/ATP6V0B/ATP6V0D1/SLC1A3/SLC6A2/AP2S1 8 KEGG hsa00730 Thiamine metabolism 3/384 15/8135 0.0311 0.4146 0.3987 ALPL/AK1/ACP1 3 KEGG hsa00270 Cysteine and methionine metabolism 6/384 51/8135 0.03189 0.4146 0.3987 GOT1/GSS/GOT2/SDSL/AHCY/SRM 6 KEGG hsa00330 Arginine and proline metabolism 6/384 51/8135 0.03189 0.4146 0.3987 GOT1/ODC1/PRODH2/OAT/GOT2/SRM 6 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 6/384 53/8135 0.03761 0.4693 0.4512 DNM2/ATP1A3/ATP2B4/AP2A2/AP2M1/AP2S1 6 KEGG hsa00230 Purine metabolism 11/384 128/8135 0.03911 0.4693 0.4512 RRM2B/PDE4B/NT5E/CANT1/PPAT/NUDT2/AK1/IMPDH1/ADA/PDE6B/HDDC3 11 KEGG hsa04925 Aldosterone synthesis and secretion 9/384 98/8135 0.04128 0.477 0.4586 ATP1A3/KCNJ5/ATP2B4/NR4A2/CALM2/ITPR3/CAMK1D/CALM1/CREB5 9 KEGG hsa00511 Other glycan degradation 3/384 18/8135 0.05028 0.5284 0.5081 NEU1/MANBA/MAN2B1 3 KEGG hsa00860 Porphyrin metabolism 5/384 43/8135 0.05048 0.5284 0.5081 UGT2B7/UGT2B17/HMOX1/GUSB/COX15 5 KEGG hsa00053 Ascorbate and aldarate metabolism 4/384 30/8135 0.05081 0.5284 0.5081 UGT2B7/UGT2B17/GUSB/UGDH 4 KEGG hsa05016 Huntington disease 21/384 306/8135 0.0538 0.5293 0.509 DCTN5/UQCRFS1/UQCRC1/MAP3K10/AP2A2/AP2M1/PSMB2/CASP3/DNAH17/DNAI2/GPX1/MAPK8/CYC1/NDUFA11/COX5A/CREB5/RB1CC1/COX8A/SLC1A3/SLC25A6/AP2S1 21 KEGG hsa05020 Prion disease 19/384 273/8135 0.05757 0.5293 0.509 UQCRFS1/CAV2/HSPA2/UQCRC1/GRIN3B/MAPK13/PSMB2/GSK3B/CASP3/ITPR3/MAPK8/CYC1/NDUFA11/COX5A/CSNK2B/CREB5/COX8A/IL1B/SLC25A6 19 KEGG hsa00531 Glycosaminoglycan degradation 3/384 19/8135 0.05768 0.5293 0.509 GNS/GUSB/HYAL4 3 KEGG hsa01210 2-Oxocarboxylic acid metabolism 3/384 19/8135 0.05768 0.5293 0.509 GOT1/IDH2/GOT2 3 KEGG hsa04932 Non-alcoholic fatty liver disease 12/384 155/8135 0.06237 0.556 0.5346 UQCRFS1/UQCRC1/MAPK13/INSR/GSK3B/CASP3/MAPK8/CYC1/NDUFA11/COX5A/COX8A/IL1B 12 KEGG hsa05163 Human cytomegalovirus infection 16/384 225/8135 0.06615 0.5733 0.5513 GNGT2/MAPK13/GSK3B/CASP3/ITGAV/CCND1/CALM2/ITPR3/GNG4/AKAP13/CALM1/CREB5/IL1B/CX3CL1/E2F1/E2F2 16 KEGG hsa03420 Nucleotide excision repair 5/384 47/8135 0.0692 0.5779 0.5557 RAD23B/POLD1/POLE4/RAD23A/CUL4B 5 KEGG hsa05100 Bacterial invasion of epithelial cells 7/384 77/8135 0.07039 0.5779 0.5557 DNM2/CAV2/CDH1/MAD2L2/ARPC4/RHOG/WASL 7 KEGG hsa00040 Pentose and glucuronate interconversions 4/384 34/8135 0.07436 0.5881 0.5655 UGT2B7/UGT2B17/GUSB/UGDH 4 KEGG hsa04657 IL-17 signaling pathway 8/384 94/8135 0.0754 0.5881 0.5655 MAPK13/GSK3B/CCL20/CASP3/MAPK8/IL1B/CSF2/IL5 8 KEGG hsa03018 RNA degradation 7/384 79/8135 0.07846 0.5952 0.5723 DCPS/EXOSC5/CNOT10/LSM4/PNPT1/DDX6/ZCCHC7 7 KEGG hsa05132 Salmonella infection 17/384 249/8135 0.08012 0.5952 0.5723 DCTN5/DNM2/RILP/MAPK13/CASP3/TXN2/PFN3/MAPK8/IRAK1/CASP5/IL1B/ARPC4/RHOG/RHOB/CYFIP1/ACBD3/WASL 17 KEGG hsa04979 Cholesterol metabolism 5/384 50/8135 0.08544 0.6199 0.5961 APOC2/LIPA/APOC1/PLTP/CETP 5 KEGG hsa05415 Diabetic cardiomyopathy 14/384 203/8135 0.09902 0.6952 0.6685 G6PD/UQCRFS1/UQCRC1/MAPK13/INSR/GSK3B/MAPK8/CPT2/CYC1/NDUFA11/COX5A/COX8A/GYS1/SLC25A6 14 KEGG hsa00190 Oxidative phosphorylation 10/384 134/8135 0.1012 0.6952 0.6685 UQCRFS1/UQCRC1/ATP6V0B/ATP6V0D1/ATP6AP1/CYC1/NDUFA11/COX5A/COX15/COX8A 10 KEGG hsa05340 Primary immunodeficiency 4/384 38/8135 0.1025 0.6952 0.6685 DCLRE1C/IGLL1/RFXANK/ADA 4 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 6/384 70/8135 0.1117 0.7418 0.7132 MAPK13/ATP6V0B/ATP6V0D1/CASP3/ATP6AP1/MAPK8 6 KEGG hsa04625 C-type lectin receptor signaling pathway 8/384 104/8135 0.1176 0.7485 0.7197 CD209/MAPK13/CALM2/ITPR3/MAPK8/MALT1/CALM1/IL1B 8 KEGG hsa04660 T cell receptor signaling pathway 8/384 104/8135 0.1176 0.7485 0.7197 CD28/MAPK13/GSK3B/MAPK8/MALT1/NFKBIB/CSF2/IL5 8 KEGG hsa03440 Homologous recombination 4/384 41/8135 0.1263 0.7622 0.7329 POLD1/RAD54L/EME1/TOP3A 4 KEGG hsa05219 Bladder cancer 4/384 41/8135 0.1263 0.7622 0.7329 CCND1/CDH1/E2F1/E2F2 4 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 8/384 106/8135 0.1273 0.7622 0.7329 ARRB1/PDE4B/NR4A2/ITPR3/AKAP13/CYP24A1/PTHLH/CREB5 8 KEGG hsa04115 p53 signaling pathway 6/384 73/8135 0.1295 0.7622 0.7329 PERP/RRM2B/GTSE1/CASP3/CCND1/CCNG1 6 KEGG hsa00380 Tryptophan metabolism 4/384 42/8135 0.1348 0.7639 0.7345 GCDH/TDO2/EHHADH/CAT 4 KEGG hsa05332 Graft-versus-host disease 4/384 42/8135 0.1348 0.7639 0.7345 CD28/KIR3DL1/IL1B/KIR2DL2 4 KEGG hsa00240 Pyrimidine metabolism 5/384 58/8135 0.1374 0.7639 0.7345 RRM2B/NT5E/CANT1/CAD/NUDT2 5 KEGG hsa04918 Thyroid hormone synthesis 6/384 75/8135 0.142 0.7639 0.7345 ASGR2/ATP1A3/ITPR3/GPX1/ASGR1/CREB5 6 KEGG hsa05214 Glioma 6/384 75/8135 0.142 0.7639 0.7345 CCND1/CALM2/CAMK1D/CALM1/E2F1/E2F2 6 KEGG hsa04970 Salivary secretion 7/384 93/8135 0.1491 0.7752 0.7453 ATP1A3/BST1/ATP2B4/SLC12A2/CALM2/ITPR3/CALM1 7 KEGG hsa05323 Rheumatoid arthritis 7/384 93/8135 0.1491 0.7752 0.7453 CD28/ATP6V0B/CCL20/ATP6V0D1/ATP6AP1/IL1B/CSF2 7 KEGG hsa04392 Hippo signaling pathway - multiple species 3/384 29/8135 0.155 0.78 0.75 WWTR1/TEAD3/YAP1 3 KEGG hsa04744 Phototransduction 3/384 29/8135 0.155 0.78 0.75 CALM2/CALM1/PDE6B 3 KEGG hsa04668 TNF signaling pathway 8/384 112/8135 0.1587 0.786 0.7558 MAPK13/CCL20/CASP3/MAPK8/CREB5/IL1B/CX3CL1/CSF2 8 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 3/384 30/8135 0.1666 0.7996 0.7688 GLYCTK/CAT/SHMT1 3 KEGG hsa01523 Antifolate resistance 3/384 30/8135 0.1666 0.7996 0.7688 SLC19A1/IL1B/SHMT1 3 KEGG hsa00360 Phenylalanine metabolism 2/384 16/8135 0.1729 0.817 0.7856 GOT1/GOT2 2 KEGG hsa03250 Viral life cycle - HIV-1 5/384 63/8135 0.1754 0.817 0.7856 ELL2/ELL/PIN1/SUPT5H/TSG101 5 KEGG hsa04640 Hematopoietic cell lineage 7/384 99/8135 0.1862 0.8377 0.8055 IL2RA/CD55/IL1B/CSF2/FCGR1A/IL5RA/IL5 7 KEGG hsa00450 Selenocompound metabolism 2/384 17/8135 0.1902 0.8377 0.8055 TXNRD1/SEPHS1 2 KEGG hsa05012 Parkinson disease 16/384 266/8135 0.1902 0.8377 0.8055 UQCRFS1/DUSP1/UQCRC1/MFN2/PSMB2/CASP3/TXN2/CALM2/ITPR3/MAPK8/CYC1/NDUFA11/COX5A/CALM1/COX8A/SLC25A6 16 KEGG hsa05135 Yersinia infection 9/384 137/8135 0.1985 0.8377 0.8055 RPS6KA1/MAPK13/GSK3B/MAPK8/IRAK1/IL1B/ARPC4/RHOG/WASL 9 KEGG hsa04218 Cellular senescence 10/384 156/8135 0.2019 0.8377 0.8055 MAPK13/CCND1/CALM2/ITPR3/CDC25A/CALM1/E2F1/E2F4/SLC25A6/E2F2 10 KEGG hsa03410 Base excision repair 3/384 33/8135 0.2027 0.8377 0.8055 POLD1/APEX2/POLE4 3 KEGG hsa04914 Progesterone-mediated oocyte maturation 7/384 102/8135 0.2061 0.8377 0.8055 ANAPC1/RPS6KA1/MAPK13/MAPK8/CDC25A/MAD2L2/PLK1 7 KEGG hsa04390 Hippo signaling pathway 10/384 157/8135 0.2073 0.8377 0.8055 BMPR1A/WWTR1/PPP2CB/GSK3B/CCND1/YWHAQ/BMPR1B/TEAD3/YAP1/CDH1 10 KEGG hsa00510 N-Glycan biosynthesis 4/384 50/8135 0.2093 0.8377 0.8055 ALG3/DOLPP1/ALG10/ALG2 4 KEGG hsa05110 Vibrio cholerae infection 4/384 50/8135 0.2093 0.8377 0.8055 SLC12A2/ATP6V0B/ATP6V0D1/ATP6AP1 4 KEGG hsa04371 Apelin signaling pathway 9/384 139/8135 0.2099 0.8377 0.8055 GNGT2/CCND1/SPHK2/CALM2/ITPR3/GNG4/CALM1/PLAT/CDH1 9 KEGG hsa01232 Nucleotide metabolism 6/384 85/8135 0.2121 0.8377 0.8055 RRM2B/NT5E/CANT1/AK1/IMPDH1/ADA 6 KEGG hsa04664 Fc epsilon RI signaling pathway 5/384 68/8135 0.217 0.8463 0.8138 MAPK13/MAPK8/CSF2/INPP5D/IL5 5 KEGG hsa04260 Cardiac muscle contraction 6/384 87/8135 0.2274 0.8656 0.8323 ATP1A3/UQCRFS1/UQCRC1/CYC1/COX5A/COX8A 6 KEGG hsa04060 Cytokine-cytokine receptor interaction 17/384 295/8135 0.2298 0.8656 0.8323 IL2RA/IFNAR1/BMPR1A/ACVR1/CCL26/CCL20/IFNAR2/BMPR1B/CCL23/IL18RAP/IL1B/CX3CL1/IL1F10/CSF2/NODAL/IL5RA/IL5 17 KEGG hsa04917 Prolactin signaling pathway 5/384 70/8135 0.2344 0.8656 0.8323 MAPK13/SOCS5/GSK3B/CCND1/MAPK8 5 KEGG hsa05161 Hepatitis B 10/384 162/8135 0.235 0.8656 0.8323 IFNAR1/MAPK13/CASP3/YWHAQ/ATP6AP1/MAPK8/CREB5/IRAK1/E2F1/E2F2 10 KEGG hsa00100 Steroid biosynthesis 2/384 20/8135 0.243 0.8656 0.8323 LIPA/CYP24A1 2 KEGG hsa04520 Adherens junction 5/384 71/8135 0.2433 0.8656 0.8323 INSR/CSNK2B/CDH1/ACP1/WASL 5 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 26/384 476/8135 0.2447 0.8656 0.8323 DCTN5/UQCRFS1/UQCRC1/MAP3K10/MAPK13/MFN2/PSMB2/TOMM40/GSK3B/CASP3/DNAH17/DNAI2/CALM2/ITPR3/GPX1/MAPK8/CYC1/NDUFA11/COX5A/CSNK2B/CALM1/RB1CC1/COX8A/IL1B/CAT/SLC25A6 26 KEGG hsa04621 NOD-like receptor signaling pathway 11/384 184/8135 0.2519 0.8656 0.8323 IFNAR1/MAPK13/MFN2/IFNAR2/TXN2/ITPR3/MAPK8/PYDC1/CASP5/IL1B/NFKBIB 11 KEGG hsa04137 Mitophagy - animal 5/384 72/8135 0.2522 0.8656 0.8323 MFN2/MAPK8/ATG9A/CSNK2B/E2F1 5 KEGG hsa01250 Biosynthesis of nucleotide sugars 3/384 37/8135 0.2532 0.8656 0.8323 GNE/GPI/UGDH 3 KEGG hsa05216 Thyroid cancer 3/384 37/8135 0.2532 0.8656 0.8323 CCND1/NCOA4/CDH1 3 KEGG hsa03008 Ribosome biogenesis in eukaryotes 7/384 109/8135 0.2552 0.8656 0.8323 SPATA5/MPHOSPH10/IMP4/EMG1/CSNK2B/POP1/POP4 7 KEGG hsa04658 Th1 and Th2 cell differentiation 6/384 92/8135 0.267 0.8821 0.8482 IL2RA/MAML3/MAPK13/MAPK8/NFKBIB/IL5 6 KEGG hsa04340 Hedgehog signaling pathway 4/384 56/8135 0.2712 0.8821 0.8482 ARRB1/SPOP/GSK3B/CCND1 4 KEGG hsa05014 Amyotrophic lateral sclerosis 20/384 364/8135 0.2713 0.8821 0.8482 DCTN5/UQCRFS1/UQCRC1/MAPK13/ANXA7/PSMB2/TOMM40/CASP3/DNAH17/PFN3/DNAI2/ITPR3/GPX1/CYC1/NDUFA11/COX5A/NUP210/RB1CC1/COX8A/CAT 20 KEGG hsa04068 FoxO signaling pathway 8/384 131/8135 0.2778 0.8821 0.8482 MAPK13/INSR/CCND1/MAPK8/CAT/PLK1/USP7/PRMT1 8 KEGG hsa00220 Arginine biosynthesis 2/384 22/8135 0.2787 0.8821 0.8482 GOT1/GOT2 2 KEGG hsa04350 TGF-beta signaling pathway 6/384 94/8135 0.2834 0.8821 0.8482 BMPR1A/ACVR1/PPP2CB/BMPR1B/E2F4/NODAL 6 KEGG hsa04141 Protein processing in endoplasmic reticulum 10/384 171/8135 0.2881 0.8821 0.8482 RAD23B/HSPA2/PRKCSH/TRAM1L1/LMAN2/RNF5/DNAJB11/MAPK8/RAD23A/DNAJC3 10 KEGG hsa00260 Glycine, serine and threonine metabolism 3/384 40/8135 0.2922 0.8821 0.8482 GLYCTK/SDSL/SHMT1 3 KEGG hsa05140 Leishmaniasis 5/384 77/8135 0.2981 0.8821 0.8482 MAPK13/IRAK1/IL1B/NFKBIB/FCGR1A 5 KEGG hsa04726 Serotonergic synapse 7/384 115/8135 0.2998 0.8821 0.8482 GNGT2/KCNJ5/DUSP1/HTR7/CASP3/ITPR3/GNG4 7 KEGG hsa04216 Ferroptosis 3/384 41/8135 0.3053 0.8821 0.8482 GSS/HMOX1/NCOA4 3 KEGG hsa04070 Phosphatidylinositol signaling system 6/384 97/8135 0.3083 0.8821 0.8482 IMPA1/CALM2/ITPR3/IPMK/CALM1/INPP5D 6 KEGG hsa04666 Fc gamma R-mediated phagocytosis 6/384 97/8135 0.3083 0.8821 0.8482 DNM2/VASP/SPHK2/INPP5D/ARPC4/FCGR1A 6 KEGG hsa04713 Circadian entrainment 6/384 97/8135 0.3083 0.8821 0.8482 GNGT2/KCNJ5/CALM2/ITPR3/GNG4/CALM1 6 KEGG hsa05215 Prostate cancer 6/384 97/8135 0.3083 0.8821 0.8482 GSK3B/CCND1/PLAT/CREB5/E2F1/E2F2 6 KEGG hsa04934 Cushing syndrome 9/384 155/8135 0.3097 0.8821 0.8482 NR5A1/GSK3B/CCND1/ITPR3/ARMC5/CREB5/E2F1/KCNA4/E2F2 9 KEGG hsa04978 Mineral absorption 4/384 60/8135 0.3141 0.8821 0.8482 ATP1A3/ATP2B4/TRPM6/HMOX1 4 KEGG hsa05416 Viral myocarditis 4/384 60/8135 0.3141 0.8821 0.8482 CD28/CD55/CASP3/CCND1 4 KEGG hsa04977 Vitamin digestion and absorption 2/384 24/8135 0.3142 0.8821 0.8482 PLB1/SLC19A1 2 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 6/384 98/8135 0.3166 0.8821 0.8482 MAPK13/CALM2/ITPR3/MAPK8/CALM1/IL1B 6 KEGG hsa04910 Insulin signaling pathway 8/384 137/8135 0.3197 0.8828 0.8488 PRKAR1A/INSR/GSK3B/CALM2/FLOT1/MAPK8/CALM1/GYS1 8 KEGG hsa05160 Hepatitis C 9/384 157/8135 0.323 0.8839 0.8499 IFNAR1/PPP2CB/GSK3B/IFNAR2/CASP3/CCND1/YWHAQ/E2F1/E2F2 9 KEGG hsa00983 Drug metabolism - other enzymes 5/384 80/8135 0.3262 0.8849 0.8509 UGT2B7/UGT2B17/RRM2B/IMPDH1/GUSB 5 KEGG hsa00071 Fatty acid degradation 3/384 43/8135 0.3315 0.8894 0.8552 GCDH/EHHADH/CPT2 3 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 6/384 100/8135 0.3335 0.8894 0.8552 IL2RA/CCL26/CCL20/CCL23/IL18RAP/CX3CL1 6 KEGG hsa04962 Vasopressin-regulated water reabsorption 3/384 44/8135 0.3446 0.9069 0.872 ARHGDIA/DCTN5/CREB5 3 KEGG hsa04024 cAMP signaling pathway 12/384 221/8135 0.3506 0.9069 0.872 ATP1A3/PDE4B/ATP2B4/GRIN3B/DRD5/CNGA2/CALM2/MAPK8/CALM1/FFAR2/CREB5/HCN2 12 KEGG hsa05010 Alzheimer disease 20/384 384/8135 0.3563 0.9069 0.872 UQCRFS1/RTN4/UQCRC1/INSR/PSMB2/GSK3B/CASP3/CALM2/ITPR3/MAPK8/CYC1/NDUFA11/COX5A/CSNK2B/CALM1/RB1CC1/COX8A/IL1B/APH1A/SLC25A6 20 KEGG hsa04630 JAK-STAT signaling pathway 9/384 162/8135 0.3565 0.9069 0.872 IL2RA/GFAP/IFNAR1/SOCS5/IFNAR2/CCND1/CSF2/IL5RA/IL5 9 KEGG hsa05169 Epstein-Barr virus infection 11/384 202/8135 0.3568 0.9069 0.872 IFNAR1/MAPK13/IFNAR2/CASP3/CCND1/MAPK8/IRAK1/NFKBIB/E2F1/USP7/E2F2 11 KEGG hsa04929 GnRH secretion 4/384 64/8135 0.3575 0.9069 0.872 ARRB1/KCNJ5/ITPR3/HCN2 4 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 12/384 223/8135 0.3621 0.9111 0.8761 UQCRFS1/UQCRC1/MAPK13/HMOX1/MAPK8/CYC1/NDUFA11/COX5A/COX8A/CAT/ACP1/SLC25A6 12 KEGG hsa04620 Toll-like receptor signaling pathway 6/384 104/8135 0.3675 0.9122 0.8771 IFNAR1/MAPK13/IFNAR2/MAPK8/IRAK1/IL1B 6 KEGG hsa04927 Cortisol synthesis and secretion 4/384 65/8135 0.3684 0.9122 0.8771 NR5A1/ITPR3/CREB5/KCNA4 4 KEGG hsa04610 Complement and coagulation cascades 5/384 85/8135 0.3735 0.9177 0.8824 SERPINF2/CD55/CD46/C4BPB/PLAT 5 KEGG hsa05131 Shigellosis 13/384 247/8135 0.3834 0.9215 0.886 MAPK13/TIFA/GSK3B/U2AF1L4/PFN3/ITPR3/MAPK8/MALT1/IL1B/NFKBIB/CSF2/ARPC4/WASL 13 KEGG hsa04720 Long-term potentiation 4/384 67/8135 0.3901 0.9215 0.886 RPS6KA1/CALM2/ITPR3/CALM1 4 KEGG hsa05221 Acute myeloid leukemia 4/384 67/8135 0.3901 0.9215 0.886 CEBPE/CCND1/CSF2/FCGR1A 4 KEGG hsa04022 cGMP-PKG signaling pathway 9/384 167/8135 0.3904 0.9215 0.886 ATP1A3/ATP2B4/INSR/VASP/CALM2/ITPR3/CALM1/CREB5/SLC25A6 9 KEGG hsa03040 Spliceosome 8/384 147/8135 0.3918 0.9215 0.886 PPIH/HSPA2/EFTUD2/LSM4/SNRPB/U2AF1L4/PRPF4/AQR 8 KEGG hsa04922 Glucagon signaling pathway 6/384 107/8135 0.3931 0.9215 0.886 CALM2/ITPR3/CALM1/CREB5/GYS1/PRMT1 6 KEGG hsa04380 Osteoclast differentiation 7/384 128/8135 0.4006 0.9215 0.886 IFNAR1/SIRPB1/MAPK13/IFNAR2/MAPK8/IL1B/FCGR1A 7 KEGG hsa00830 Retinol metabolism 4/384 68/8135 0.4009 0.9215 0.886 UGT2B7/UGT2B17/PNPLA4/CYP26B1 4 KEGG hsa04931 Insulin resistance 6/384 108/8135 0.4017 0.9215 0.886 RPS6KA1/INSR/GSK3B/MAPK8/CREB5/GYS1 6 KEGG hsa04672 Intestinal immune network for IgA production 3/384 49/8135 0.4096 0.9241 0.8886 CD28/ICOSLG/IL5 3 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 5/384 89/8135 0.4115 0.9241 0.8886 CD28/MAPK13/CSNK2B/NFKBIB/BATF 5 KEGG hsa05031 Amphetamine addiction 4/384 69/8135 0.4117 0.9241 0.8886 GRIN3B/CALM2/CALM1/CREB5 4 KEGG hsa00020 Citrate cycle (TCA cycle) 2/384 30/8135 0.4174 0.9252 0.8896 ACLY/IDH2 2 KEGG hsa04062 Chemokine signaling pathway 10/384 192/8135 0.4211 0.9252 0.8896 GNGT2/ARRB1/CCL26/GSK3B/CCL20/GNG4/CCL23/PREX1/CX3CL1/NFKBIB 10 KEGG hsa04622 RIG-I-like receptor signaling pathway 4/384 70/8135 0.4225 0.9252 0.8896 PIN1/MAPK13/MAPK8/NFKBIB 4 KEGG hsa04650 Natural killer cell mediated cytotoxicity 7/384 131/8135 0.424 0.9252 0.8896 IFNAR1/RAET1E/IFNAR2/CASP3/KIR3DL1/CSF2/KIR2DL2 7 KEGG hsa05032 Morphine addiction 5/384 91/8135 0.4303 0.9324 0.8965 GNGT2/ARRB1/KCNJ5/PDE4B/GNG4 5 KEGG hsa05145 Toxoplasmosis 6/384 112/8135 0.4357 0.9362 0.9002 HSPA2/MAPK13/CASP3/MAPK8/IRAK1/NFKBIB 6 KEGG hsa05222 Small cell lung cancer 5/384 92/8135 0.4397 0.9362 0.9002 CASP3/ITGAV/CCND1/E2F1/E2F2 5 KEGG hsa05218 Melanoma 4/384 72/8135 0.4438 0.9362 0.9002 CCND1/CDH1/E2F1/E2F2 4 KEGG hsa04912 GnRH signaling pathway 5/384 93/8135 0.4491 0.9362 0.9002 MAPK13/CALM2/ITPR3/MAPK8/CALM1 5 KEGG hsa04136 Autophagy - other 2/384 32/8135 0.4501 0.9362 0.9002 PPP2CB/ATG9A 2 KEGG hsa04215 Apoptosis - multiple species 2/384 32/8135 0.4501 0.9362 0.9002 CASP3/MAPK8 2 KEGG hsa04020 Calcium signaling pathway 12/384 240/8135 0.4614 0.9442 0.9079 ATP2B4/HTR7/GRPR/PTAFR/DRD5/SPHK2/CALM2/ITPR3/CAMK1D/MCOLN1/CALM1/SLC25A6 12 KEGG hsa03450 Non-homologous end-joining 1/384 13/8135 0.4669 0.9442 0.9079 DCLRE1C 1 KEGG hsa03010 Ribosome 8/384 158/8135 0.4714 0.9442 0.9079 MRPL10/MRPS15/MRPL28/MRPS5/MRPS2/RPL18A/MRPS11/RPS4X 8 KEGG hsa03460 Fanconi anemia pathway 3/384 54/8135 0.4725 0.9442 0.9079 EME1/TOP3A/FANCG 3 KEGG hsa04915 Estrogen signaling pathway 7/384 138/8135 0.4783 0.9442 0.9079 KCNJ5/HSPA2/CALM2/ITPR3/CALM1/CREB5/KRT17 7 KEGG hsa04971 Gastric acid secretion 4/384 76/8135 0.4857 0.9442 0.9079 ATP1A3/CALM2/ITPR3/CALM1 4 KEGG hsa05212 Pancreatic cancer 4/384 76/8135 0.4857 0.9442 0.9079 CCND1/MAPK8/E2F1/E2F2 4 KEGG hsa01522 Endocrine resistance 5/384 98/8135 0.4951 0.9442 0.9079 MAPK13/CCND1/MAPK8/E2F1/E2F2 5 KEGG hsa04612 Antigen processing and presentation 4/384 78/8135 0.5062 0.9442 0.9079 HSPA2/RFXANK/KIR3DL1/KIR2DL2 4 KEGG hsa04936 Alcoholic liver disease 7/384 142/8135 0.5087 0.9442 0.9079 MAPK13/GSK3B/CASP3/CCND1/MAPK8/IRAK1/IL1B 7 KEGG hsa05134 Legionellosis 3/384 57/8135 0.5087 0.9442 0.9079 HSPA2/CASP3/IL1B 3 KEGG hsa00350 Tyrosine metabolism 2/384 36/8135 0.5123 0.9442 0.9079 GOT1/GOT2 2 KEGG hsa00500 Starch and sucrose metabolism 2/384 36/8135 0.5123 0.9442 0.9079 GPI/GYS1 2 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 5/384 100/8135 0.5131 0.9442 0.9079 MAPK13/CASP3/CCND1/MAPK8/IL1B 5 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/384 15/8135 0.5161 0.9442 0.9079 GBGT1 1 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 7/384 143/8135 0.5162 0.9442 0.9079 BMPR1A/ACVR1/MAPK13/GSK3B/BMPR1B/KLF4/NODAL 7 KEGG hsa05213 Endometrial cancer 3/384 58/8135 0.5205 0.9442 0.9079 GSK3B/CCND1/CDH1 3 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 2/384 37/8135 0.5271 0.9442 0.9079 ATP1A3/INSR 2 KEGG hsa05143 African trypanosomiasis 2/384 37/8135 0.5271 0.9442 0.9079 THOP1/IL1B 2 KEGG hsa04972 Pancreatic secretion 5/384 102/8135 0.5309 0.9442 0.9079 ATP1A3/BST1/ATP2B4/SLC12A2/ITPR3 5 KEGG hsa05142 Chagas disease 5/384 102/8135 0.5309 0.9442 0.9079 MAPK13/PPP2CB/MAPK8/IRAK1/IL1B 5 KEGG hsa04015 Rap1 signaling pathway 10/384 210/8135 0.5354 0.9442 0.9079 MAPK13/INSR/PGF/PFN3/VASP/CALM2/CALM1/CDH1/SIPA1/FPR1 10 KEGG hsa04714 Thermogenesis 11/384 232/8135 0.5386 0.9442 0.9079 UQCRFS1/RPS6KA1/UQCRC1/MAPK13/CPT2/CYC1/NDUFA11/COX5A/COX15/CREB5/COX8A 11 KEGG hsa00430 Taurine and hypotaurine metabolism 1/384 16/8135 0.539 0.9442 0.9079 FMO1 1 KEGG hsa05330 Allograft rejection 2/384 38/8135 0.5416 0.9442 0.9079 CD28/IL5 2 KEGG hsa04662 B cell receptor signaling pathway 4/384 82/8135 0.546 0.9442 0.9079 GSK3B/MALT1/NFKBIB/INPP5D 4 KEGG hsa05170 Human immunodeficiency virus 1 infection 10/384 212/8135 0.5476 0.9442 0.9079 GNGT2/MAPK13/CASP3/CALM2/ITPR3/GNG4/MAPK8/CALM1/IRAK1/CUL4B 10 KEGG hsa04064 NF-kappa B signaling pathway 5/384 104/8135 0.5484 0.9442 0.9079 CARD14/MALT1/CSNK2B/IRAK1/IL1B 5 KEGG hsa04530 Tight junction 8/384 169/8135 0.5486 0.9442 0.9079 ARHGEF18/PPP2CB/VASP/CCND1/MAPK8/SYMPK/CGN/ARPC4 8 KEGG hsa04723 Retrograde endocannabinoid signaling 7/384 148/8135 0.5531 0.9442 0.9079 GNGT2/KCNJ5/MAPK13/ITPR3/GNG4/MAPK8/NDUFA11 7 KEGG hsa00590 Arachidonic acid metabolism 3/384 61/8135 0.555 0.9442 0.9079 PLB1/PTGES2/GPX1 3 KEGG hsa00513 Various types of N-glycan biosynthesis 2/384 39/8135 0.5557 0.9442 0.9079 ALG3/ALG2 2 KEGG hsa04514 Cell adhesion molecules 7/384 149/8135 0.5603 0.9442 0.9079 CD28/CDH15/ITGAV/PVR/ICOSLG/CDH1/MAG 7 KEGG hsa05164 Influenza A 8/384 171/8135 0.5622 0.9442 0.9079 IFNAR1/IFNAR2/CASP3/IL1B/NFKBIB/TPSAB1/DNAJC3/SLC25A6 8 KEGG hsa04213 Longevity regulating pathway - multiple species 3/384 62/8135 0.5661 0.9442 0.9079 HSPA2/INSR/CAT 3 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 7/384 150/8135 0.5675 0.9442 0.9079 ATP1A3/ATP2B4/MAPK13/PPP2CB/CALM2/CALM1/CREB5 7 KEGG hsa04926 Relaxin signaling pathway 6/384 129/8135 0.5741 0.9442 0.9079 GNGT2/ARRB1/MAPK13/GNG4/MAPK8/CREB5 6 KEGG hsa00310 Lysine degradation 3/384 63/8135 0.5771 0.9442 0.9079 GCDH/EHHADH/SUV39H1 3 KEGG hsa04623 Cytosolic DNA-sensing pathway 3/384 63/8135 0.5771 0.9442 0.9079 POLR3K/IL1B/NFKBIB 3 KEGG hsa04145 Phagosome 7/384 152/8135 0.5817 0.9442 0.9079 RILP/CD209/ATP6V0B/ATP6V0D1/ITGAV/ATP6AP1/FCGR1A 7 KEGG hsa03013 Nucleocytoplasmic transport 5/384 108/8135 0.5823 0.9442 0.9079 IPO11/XPO6/XPO7/NUP210/RANGAP1 5 KEGG hsa04659 Th17 cell differentiation 5/384 108/8135 0.5823 0.9442 0.9079 IL2RA/MAPK13/MAPK8/IL1B/NFKBIB 5 KEGG hsa05210 Colorectal cancer 4/384 86/8135 0.5841 0.9442 0.9079 GSK3B/CASP3/CCND1/MAPK8 4 KEGG hsa05130 Pathogenic Escherichia coli infection 9/384 197/8135 0.589 0.9473 0.9109 MAPK13/CASP3/MAPK8/IRAK1/IL1B/NFKBIB/ARPC4/CYFIP1/WASL 9 KEGG hsa05321 Inflammatory bowel disease 3/384 65/8135 0.5985 0.9505 0.914 IL18RAP/IL1B/IL5 3 KEGG hsa04940 Type I diabetes mellitus 2/384 43/8135 0.6093 0.9505 0.914 CD28/IL1B 2 KEGG hsa04211 Longevity regulating pathway 4/384 89/8135 0.6114 0.9505 0.914 INSR/CREB5/RB1CC1/CAT 4 KEGG hsa04727 GABAergic synapse 4/384 89/8135 0.6114 0.9505 0.914 GNGT2/GNG4/PLCL1/SLC38A5 4 KEGG hsa04976 Bile secretion 4/384 89/8135 0.6114 0.9505 0.914 ATP1A3/UGT2B7/UGT2B17/AQP9 4 KEGG hsa00670 One carbon pool by folate 1/384 20/8135 0.6202 0.9505 0.914 SHMT1 1 KEGG hsa04217 Necroptosis 7/384 159/8135 0.6296 0.9505 0.914 IFNAR1/CHMP7/IFNAR2/MAPK8/CHMP1B/IL1B/SLC25A6 7 KEGG hsa04724 Glutamatergic synapse 5/384 114/8135 0.6306 0.9505 0.914 GNGT2/GRIN3B/ITPR3/GNG4/SLC1A3 5 KEGG hsa03022 Basal transcription factors 2/384 45/8135 0.6342 0.9505 0.914 TAF10/GTF2F1 2 KEGG hsa00770 Pantothenate and CoA biosynthesis 1/384 21/8135 0.6382 0.9505 0.914 COASY 1 KEGG hsa04924 Renin secretion 3/384 69/8135 0.6392 0.9505 0.914 CALM2/ITPR3/CALM1 3 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 3/384 69/8135 0.6392 0.9505 0.914 UGT2B7/UGT2B17/SULT1A4 3 KEGG hsa04930 Type II diabetes mellitus 2/384 46/8135 0.6462 0.9505 0.914 INSR/MAPK8 2 KEGG hsa00900 Terpenoid backbone biosynthesis 1/384 22/8135 0.6553 0.9505 0.914 MVD 1 KEGG hsa04973 Carbohydrate digestion and absorption 2/384 47/8135 0.6579 0.9505 0.914 ATP1A3/SLC37A4 2 KEGG hsa05171 Coronavirus disease - COVID-19 10/384 232/8135 0.6624 0.9505 0.914 IFNAR1/MAPK13/IFNAR2/MAPK8/RPL18A/IRAK1/IL1B/NFKBIB/CSF2/RPS4X 10 KEGG hsa00982 Drug metabolism - cytochrome P450 3/384 72/8135 0.6677 0.9505 0.914 UGT2B7/UGT2B17/FMO1 3 KEGG hsa05223 Non-small cell lung cancer 3/384 72/8135 0.6677 0.9505 0.914 CCND1/E2F1/E2F2 3 KEGG hsa04935 Growth hormone synthesis, secretion and action 5/384 119/8135 0.6681 0.9505 0.914 MAPK13/GSK3B/ITPR3/MAPK8/CREB5 5 KEGG hsa05150 Staphylococcus aureus infection 4/384 96/8135 0.6707 0.9505 0.914 PTAFR/KRT17/FCGR1A/FPR1 4 KEGG hsa03430 Mismatch repair 1/384 23/8135 0.6717 0.9505 0.914 POLD1 1 KEGG hsa04614 Renin-angiotensin system 1/384 23/8135 0.6717 0.9505 0.914 THOP1 1 KEGG hsa04964 Proximal tubule bicarbonate reclamation 1/384 23/8135 0.6717 0.9505 0.914 ATP1A3 1 KEGG hsa05017 Spinocerebellar ataxia 6/384 143/8135 0.6741 0.9505 0.914 GRIN3B/PSMB2/ITPR3/MAPK8/RB1CC1/SLC25A6 6 KEGG hsa04152 AMPK signaling pathway 5/384 120/8135 0.6753 0.9505 0.914 INSR/PPP2CB/CCND1/CREB5/GYS1 5 KEGG hsa05207 Chemical carcinogenesis - receptor activation 9/384 212/8135 0.6764 0.9505 0.914 UGT2B7/ARRB1/UGT2B17/RPS6KA1/CCND1/CDC25A/CREB5/E2F1/KLF4 9 KEGG hsa00562 Inositol phosphate metabolism 3/384 73/8135 0.6769 0.9505 0.914 IMPA1/IPMK/INPP5D 3 KEGG hsa00565 Ether lipid metabolism 2/384 49/8135 0.6803 0.9505 0.914 PLB1/PAFAH1B3 2 KEGG hsa05030 Cocaine addiction 2/384 49/8135 0.6803 0.9505 0.914 GRIN3B/CREB5 2 KEGG hsa04919 Thyroid hormone signaling pathway 5/384 121/8135 0.6824 0.9505 0.914 HDAC3/ATP1A3/GSK3B/ITGAV/CCND1 5 KEGG hsa05417 Lipid and atherosclerosis 9/384 215/8135 0.6925 0.9589 0.922 HSPA2/MAPK13/GSK3B/CASP3/CALM2/MAPK8/CALM1/IRAK1/IL1B 9 KEGG hsa03320 PPAR signaling pathway 3/384 75/8135 0.6946 0.9589 0.922 EHHADH/CPT2/PLTP 3 KEGG hsa00592 alpha-Linolenic acid metabolism 1/384 25/8135 0.702 0.9622 0.9252 PLB1 1 KEGG hsa05220 Chronic myeloid leukemia 3/384 76/8135 0.7032 0.9622 0.9252 CCND1/E2F1/E2F2 3 KEGG hsa00600 Sphingolipid metabolism 2/384 52/8135 0.7116 0.9672 0.93 SPHK2/NEU1 2 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/384 26/8135 0.7161 0.9672 0.93 PIGC 1 KEGG hsa00790 Folate biosynthesis 1/384 26/8135 0.7161 0.9672 0.93 ALPL 1 KEGG hsa05320 Autoimmune thyroid disease 2/384 53/8135 0.7215 0.9703 0.9329 CD28/IL5 2 KEGG hsa05166 Human T-cell leukemia virus 1 infection 9/384 222/8135 0.728 0.9727 0.9353 IL2RA/ANAPC1/CCND1/MAPK8/CREB5/E2F1/CSF2/SLC25A6/E2F2 9 KEGG hsa04966 Collecting duct acid secretion 1/384 27/8135 0.7296 0.9727 0.9353 ATP6V0D1 1 KEGG hsa04921 Oxytocin signaling pathway 6/384 154/8135 0.7414 0.9736 0.9362 KCNJ5/CCND1/CALM2/ITPR3/CAMK1D/CALM1 6 KEGG hsa00650 Butanoate metabolism 1/384 28/8135 0.7424 0.9736 0.9362 EHHADH 1 KEGG hsa04146 Peroxisome 3/384 82/8135 0.7508 0.9736 0.9362 EHHADH/IDH2/CAT 3 KEGG hsa00591 Linoleic acid metabolism 1/384 29/8135 0.7546 0.9736 0.9362 PLB1 1 KEGG hsa01212 Fatty acid metabolism 2/384 57/8135 0.7581 0.9736 0.9362 EHHADH/CPT2 2 KEGG hsa04360 Axon guidance 7/384 182/8135 0.7629 0.9736 0.9362 GSK3B/RYK/SSH2/FES/BMPR1B/SEMA6B/DPYSL2 7 KEGG hsa04740 Olfactory transduction 18/384 440/8135 0.7711 0.9736 0.9362 OR2H2/OR6C2/ARRB1/OR4A16/OR1D2/OR2C1/CNGA2/CALM2/OR2A25/OR4X2/OR2A1/OR5P2/CALM1/OR12D2/OR6C68/OR4K2/OR5B21/OR51E2 18 KEGG hsa04014 Ras signaling pathway 9/384 232/8135 0.7739 0.9736 0.9362 GNGT2/HTR7/INSR/PGF/CALM2/GNG4/MAPK8/CALM1/BRAP 9 KEGG hsa04330 Notch signaling pathway 2/384 59/8135 0.7748 0.9736 0.9362 MAML3/APH1A 2 KEGG hsa04370 VEGF signaling pathway 2/384 59/8135 0.7748 0.9736 0.9362 MAPK13/SPHK2 2 KEGG hsa00410 beta-Alanine metabolism 1/384 31/8135 0.7773 0.9736 0.9362 EHHADH 1 KEGG hsa05310 Asthma 1/384 31/8135 0.7773 0.9736 0.9362 IL5 1 KEGG hsa04911 Insulin secretion 3/384 86/8135 0.7791 0.9736 0.9362 ATP1A3/ITPR3/CREB5 3 KEGG hsa04730 Long-term depression 2/384 60/8135 0.7828 0.9736 0.9362 PPP2CB/ITPR3 2 KEGG hsa05034 Alcoholism 7/384 187/8135 0.7867 0.9736 0.9362 HDAC3/GNGT2/GRIN3B/CALM2/GNG4/CALM1/CREB5 7 KEGG hsa04725 Cholinergic synapse 4/384 113/8135 0.7876 0.9736 0.9362 GNGT2/ITPR3/GNG4/CREB5 4 KEGG hsa00640 Propanoate metabolism 1/384 32/8135 0.7878 0.9736 0.9362 EHHADH 1 KEGG hsa00140 Steroid hormone biosynthesis 2/384 61/8135 0.7905 0.9736 0.9362 UGT2B7/UGT2B17 2 KEGG hsa04151 PI3K-Akt signaling pathway 14/384 354/8135 0.7915 0.9736 0.9362 IL2RA/GNGT2/IFNAR1/INSR/PPP2CB/GSK3B/IFNAR2/PGF/ITGAV/CCND1/YWHAQ/GNG4/CREB5/GYS1 14 KEGG hsa05165 Human papillomavirus infection 13/384 331/8135 0.7926 0.9736 0.9362 MAML3/IFNAR1/ATP6V0B/PPP2CB/GSK3B/ATP6V0D1/IFNAR2/CASP3/ITGAV/CCND1/ATP6AP1/CREB5/E2F1 13 KEGG hsa04140 Autophagy - animal 5/384 141/8135 0.8024 0.9803 0.9426 PPP2CB/MAPK8/ATG9A/UVRAG/RB1CC1 5 KEGG hsa04310 Wnt signaling pathway 6/384 167/8135 0.8073 0.9803 0.9426 GSK3B/CCND1/RYK/MAPK8/CSNK2B/DAAM1 6 KEGG hsa03020 RNA polymerase 1/384 34/8135 0.8075 0.9803 0.9426 POLR3K 1 KEGG hsa05225 Hepatocellular carcinoma 6/384 168/8135 0.8118 0.9817 0.9439 TXNRD1/GSK3B/HMOX1/CCND1/E2F1/E2F2 6 KEGG hsa04071 Sphingolipid signaling pathway 4/384 119/8135 0.82 0.9878 0.9498 MAPK13/PPP2CB/SPHK2/MAPK8 4 KEGG hsa00512 Mucin type O-glycan biosynthesis 1/384 36/8135 0.8253 0.989 0.951 ST6GALNAC1 1 KEGG hsa04010 MAPK signaling pathway 11/384 294/8135 0.8273 0.989 0.951 ARRB1/DUSP1/HSPA2/RPS6KA1/MAPK13/INSR/CASP3/PGF/MAPK8/IRAK1/IL1B 11 KEGG hsa00010 Glycolysis / Gluconeogenesis 2/384 67/8135 0.832 0.99 0.9519 GPI/ADPGK 2 KEGG hsa05226 Gastric cancer 5/384 149/8135 0.8391 0.99 0.9519 GSK3B/CCND1/CDH1/E2F1/E2F2 5 KEGG hsa03015 mRNA surveillance pathway 3/384 97/8135 0.8434 0.99 0.9519 PPP2CB/SYMPK/SMG5 3 KEGG hsa04510 Focal adhesion 7/384 201/8135 0.8439 0.99 0.9519 CAV2/GSK3B/PGF/VASP/ITGAV/CCND1/MAPK8 7 KEGG hsa04920 Adipocytokine signaling pathway 2/384 69/8135 0.844 0.99 0.9519 MAPK8/NFKBIB 2 KEGG hsa05230 Central carbon metabolism in cancer 2/384 70/8135 0.8498 0.9911 0.953 G6PD/IDH2 2 KEGG hsa05203 Viral carcinogenesis 7/384 204/8135 0.8544 0.9911 0.953 HDAC3/ATP6V0D1/CASP3/CCND1/YWHAQ/CREB5/USP7 7 KEGG hsa05033 Nicotine addiction 1/384 40/8135 0.8561 0.9911 0.953 GRIN3B 1 KEGG hsa05205 Proteoglycans in cancer 7/384 205/8135 0.8577 0.9911 0.953 CAV2/MAPK13/CASP3/ITGAV/CCND1/ITPR3/NUDT16L1 7 KEGG hsa04916 Melanogenesis 3/384 101/8135 0.8624 0.9929 0.9547 GSK3B/CALM2/CALM1 3 KEGG hsa05146 Amoebiasis 3/384 102/8135 0.8668 0.9943 0.956 CASP3/IL1B/CSF2 3 KEGG hsa04974 Protein digestion and absorption 3/384 103/8135 0.8711 0.9947 0.9564 ATP1A3/COL14A1/SLC15A1 3 KEGG hsa04975 Fat digestion and absorption 1/384 43/8135 0.8757 0.9947 0.9564 GOT2 1 KEGG hsa02010 ABC transporters 1/384 45/8135 0.8872 0.9947 0.9564 ABCB9 1 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 2/384 78/8135 0.8892 0.9947 0.9564 UGT2B7/UGT2B17 2 KEGG hsa04613 Neutrophil extracellular trap formation 6/384 190/8135 0.891 0.9947 0.9564 HDAC3/MAPK13/AQP9/FCGR1A/SLC25A6/FPR1 6 KEGG hsa03050 Proteasome 1/384 46/8135 0.8925 0.9947 0.9564 PSMB2 1 KEGG hsa04066 HIF-1 signaling pathway 3/384 109/8135 0.8944 0.9947 0.9564 INSR/HMOX1/EGLN2 3 KEGG hsa05202 Transcriptional misregulation in cancer 6/384 193/8135 0.8993 0.9947 0.9564 CEBPE/JMJD1C/PLAT/CSF2/LYL1/FCGR1A 6 KEGG hsa00280 Valine, leucine and isoleucine degradation 1/384 48/8135 0.9025 0.9947 0.9564 EHHADH 1 KEGG hsa04670 Leukocyte transendothelial migration 3/384 114/8135 0.9109 0.9947 0.9564 MAPK13/VASP/SIPA1 3 KEGG hsa05144 Malaria 1/384 50/8135 0.9115 0.9947 0.9564 IL1B 1 KEGG hsa04012 ErbB signaling pathway 2/384 85/8135 0.9156 0.9947 0.9564 GSK3B/MAPK8 2 KEGG hsa04913 Ovarian steroidogenesis 1/384 51/8135 0.9157 0.9947 0.9564 INSR 1 KEGG hsa04742 Taste transduction 2/384 86/8135 0.9189 0.9947 0.9564 PKD2L1/ITPR3 2 KEGG hsa05224 Breast cancer 4/384 147/8135 0.9219 0.9947 0.9564 GSK3B/CCND1/E2F1/E2F2 4 KEGG hsa04512 ECM-receptor interaction 2/384 88/8135 0.925 0.9947 0.9564 CD47/ITGAV 2 KEGG hsa04923 Regulation of lipolysis in adipocytes 1/384 56/8135 0.9339 0.9947 0.9564 INSR 1 KEGG hsa04611 Platelet activation 3/384 124/8135 0.937 0.9947 0.9564 MAPK13/VASP/ITPR3 3 KEGG hsa04150 mTOR signaling pathway 4/384 156/8135 0.9414 0.9947 0.9564 RPS6KA1/RICTOR/INSR/GSK3B 4 KEGG hsa00561 Glycerolipid metabolism 1/384 61/8135 0.9482 0.9947 0.9564 GLYCTK 1 KEGG hsa04810 Regulation of actin cytoskeleton 6/384 218/8135 0.9494 0.9947 0.9564 PFN3/ITGAV/SSH2/ARPC4/CYFIP1/WASL 6 KEGG hsa05217 Basal cell carcinoma 1/384 63/8135 0.953 0.9947 0.9564 GSK3B 1 KEGG hsa04270 Vascular smooth muscle contraction 3/384 134/8135 0.9559 0.9947 0.9564 CALM2/ITPR3/CALM1 3 KEGG hsa04210 Apoptosis 3/384 136/8135 0.959 0.9947 0.9564 CASP3/ITPR3/MAPK8 3 KEGG hsa05322 Systemic lupus erythematosus 3/384 136/8135 0.959 0.9947 0.9564 CD28/SNRPB/FCGR1A 3 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/384 66/8135 0.9594 0.9947 0.9564 SARS2 1 KEGG hsa05211 Renal cell carcinoma 1/384 69/8135 0.9649 0.9947 0.9564 EGLN2 1 KEGG hsa04120 Ubiquitin mediated proteolysis 3/384 142/8135 0.9671 0.9947 0.9564 ANAPC1/CUL4B/UBE2B 3 KEGG hsa01524 Platinum drug resistance 1/384 73/8135 0.9712 0.9947 0.9564 CASP3 1 KEGG hsa04072 Phospholipase D signaling pathway 3/384 148/8135 0.9736 0.9947 0.9564 DNM2/INSR/SPHK2 3 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 1/384 77/8135 0.9763 0.9947 0.9564 ITGAV 1 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 1/384 79/8135 0.9785 0.9947 0.9564 GSK3B 1 KEGG hsa05206 MicroRNAs in cancer 8/384 310/8135 0.9817 0.9947 0.9564 HMOX1/CASP3/CCND1/CDC25A/CYP24A1/E2F1/CCNG1/E2F2 8 KEGG hsa04540 Gap junction 1/384 88/8135 0.9861 0.9947 0.9564 ITPR3 1 KEGG hsa05410 Hypertrophic cardiomyopathy 1/384 90/8135 0.9874 0.9947 0.9564 ITGAV 1 KEGG hsa04080 Neuroactive ligand-receptor interaction 9/384 353/8135 0.9879 0.9947 0.9564 HTR7/GRIN3B/GALR2/GRPR/PTAFR/CHRNA10/DRD5/HCRT/FPR1 9 KEGG hsa05414 Dilated cardiomyopathy 1/384 96/8135 0.9906 0.9947 0.9564 ITGAV 1 KEGG hsa00564 Glycerophospholipid metabolism 1/384 98/8135 0.9915 0.9947 0.9564 PLB1 1 KEGG hsa05231 Choline metabolism in cancer 1/384 98/8135 0.9915 0.9947 0.9564 MAPK8 1 KEGG hsa05168 Herpes simplex virus 1 infection 11/384 495/8135 0.999 0.999 0.9606 ZNF8/IFNAR1/ZNF585B/HCFC1/IFNAR2/ZNF707/CASP3/ZNF680/IRAK1/IL1B/ZNF282 11