ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04022 cGMP-PKG signaling pathway 12/201 167/8135 0.0008548 0.2222 0.2195 CALM1/ATP2B4/PLN/SLC25A6/ATP1B3/PPP1CA/GTF2IRD1/CNGB1/ADCY2/SLC25A5/EDNRB/PPP1CB 12 KEGG hsa05168 Herpes simplex virus 1 infection 22/201 495/8135 0.005216 0.4588 0.4532 ZNF599/ZNF81/ZNF417/ZNF43/ZNF786/ZNF85/HLA-DQB1/HLA-DOA/PPP1CA/ZNF324/ZNF222/CYCS/BST2/ZNF641/ZNF268/IRAK1/ZNF749/ZNF10/ZNF746/ZNF836/PPP1CB/ZNF597 22 KEGG hsa04744 Phototransduction 4/201 29/8135 0.005293 0.4588 0.4532 CALM1/GUCA1B/RHO/CNGB1 4 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 3/201 20/8135 0.01242 0.6057 0.5983 CHSY1/CSGALNACT2/XYLT1 3 KEGG hsa00513 Various types of N-glycan biosynthesis 4/201 39/8135 0.01514 0.6057 0.5983 RPN2/MGAT4A/B4GALNT3/RPN1 4 KEGG hsa05016 Huntington disease 14/201 306/8135 0.01925 0.6057 0.5983 PSMC2/PSMD13/CLTB/SLC25A6/PSMB6/PSMD3/SDHB/AP2S1/SLC25A5/CYCS/TFAM/TUBB2A/BDNF/CREBBP 14 KEGG hsa03250 Viral life cycle - HIV-1 5/201 63/8135 0.01934 0.6057 0.5983 FEZ1/BST2/SUPT5H/CHMP4B/CREBBP 5 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 3/201 24/8135 0.02053 0.6057 0.5983 NDST1/XYLT1/HS3ST5 3 KEGG hsa04024 cAMP signaling pathway 11/201 221/8135 0.02097 0.6057 0.5983 CALM1/ATP2B4/PLN/ATP1B3/PPP1CA/CNGB1/ADCY2/GPHA2/BDNF/PPP1CB/CREBBP 11 KEGG hsa01200 Carbon metabolism 7/201 115/8135 0.02355 0.6124 0.605 PRPS1L1/SDHB/SHMT1/HK2/PGK1/ACSS1/TKTL1 7 KEGG hsa03050 Proteasome 4/201 46/8135 0.0263 0.6217 0.6142 PSMC2/PSMD13/PSMB6/PSMD3 4 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 8/201 150/8135 0.03223 0.6983 0.6899 CALM1/ATP2B4/PLN/ATP1B3/PPP1CA/PPP2R5E/ADCY2/PPP1CB 8 KEGG hsa04218 Cellular senescence 8/201 156/8135 0.03929 0.7483 0.7392 CALM1/ZFP36L1/RAD9B/SLC25A6/PPP1CA/PPID/SLC25A5/PPP1CB 8 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 4/201 53/8135 0.04137 0.7483 0.7392 ATP2B4/CLTB/ATP1B3/AP2S1 4 KEGG hsa04217 Necroptosis 8/201 159/8135 0.04317 0.7483 0.7392 SLC25A6/PPID/CHMP7/TNFAIP3/SLC25A5/TNFRSF10B/CHMP4B/SPATA2 8 KEGG hsa00051 Fructose and mannose metabolism 3/201 33/8135 0.04711 0.7537 0.7445 PFKFB1/SORD/HK2 3 KEGG hsa05145 Toxoplasmosis 6/201 112/8135 0.05862 0.7537 0.7445 HLA-DQB1/HLA-DOA/LAMC3/CYCS/IRAK1/LAMC1 6 KEGG hsa05416 Viral myocarditis 4/201 60/8135 0.06042 0.7537 0.7445 PRF1/HLA-DQB1/HLA-DOA/CYCS 4 KEGG hsa05169 Epstein-Barr virus infection 9/201 202/8135 0.06264 0.7537 0.7445 PSMC2/PSMD13/HLA-DQB1/HLA-DOA/PSMD3/TNFAIP3/CYCS/ISG15/IRAK1 9 KEGG hsa00561 Glycerolipid metabolism 4/201 61/8135 0.06347 0.7537 0.7445 GPAT2/AGPAT1/DGKK/MBOAT1 4 KEGG hsa05017 Spinocerebellar ataxia 7/201 143/8135 0.06374 0.7537 0.7445 PSMC2/PSMD13/SLC25A6/PSMB6/PSMD3/SLC25A5/CYCS 7 KEGG hsa00120 Primary bile acid biosynthesis 2/201 17/8135 0.06479 0.7537 0.7445 ACOT8/AKR1C4 2 KEGG hsa05330 Allograft rejection 3/201 38/8135 0.06667 0.7537 0.7445 PRF1/HLA-DQB1/HLA-DOA 3 KEGG hsa04720 Long-term potentiation 4/201 67/8135 0.08338 0.8602 0.8498 CALM1/PPP1CA/PPP1CB/CREBBP 4 KEGG hsa05332 Graft-versus-host disease 3/201 42/8135 0.08457 0.8602 0.8498 PRF1/HLA-DQB1/HLA-DOA 3 KEGG hsa00670 One carbon pool by folate 2/201 20/8135 0.08629 0.8602 0.8498 ALDH1L2/SHMT1 2 KEGG hsa04940 Type I diabetes mellitus 3/201 43/8135 0.08933 0.8602 0.8498 PRF1/HLA-DQB1/HLA-DOA 3 KEGG hsa04916 Melanogenesis 5/201 101/8135 0.1044 0.8648 0.8543 CALM1/ADCY2/EDNRB/WNT5B/CREBBP 5 KEGG hsa00562 Inositol phosphate metabolism 4/201 73/8135 0.106 0.8648 0.8543 INPP5E/INPP4A/PLCH2/ISYNA1 4 KEGG hsa04964 Proximal tubule bicarbonate reclamation 2/201 23/8135 0.1096 0.8648 0.8543 ATP1B3/GLS2 2 KEGG hsa01230 Biosynthesis of amino acids 4/201 75/8135 0.1141 0.8648 0.8543 PRPS1L1/SHMT1/PGK1/TKTL1 4 KEGG hsa04971 Gastric acid secretion 4/201 76/8135 0.1182 0.8648 0.8543 CALM1/ATP1B3/KCNK2/ADCY2 4 KEGG hsa04210 Apoptosis 6/201 136/8135 0.1202 0.8648 0.8543 PRF1/CTSZ/CTSL/DIABLO/CYCS/TNFRSF10B 6 KEGG hsa05012 Parkinson disease 10/201 266/8135 0.1226 0.8648 0.8543 PSMC2/CALM1/PSMD13/SLC25A6/PSMB6/PSMD3/SDHB/SLC25A5/CYCS/TUBB2A 10 KEGG hsa04922 Glucagon signaling pathway 5/201 107/8135 0.125 0.8648 0.8543 CALM1/PRKAA1/PFKFB1/ADCY2/CREBBP 5 KEGG hsa00510 N-Glycan biosynthesis 3/201 50/8135 0.1256 0.8648 0.8543 RPN2/MGAT4A/RPN1 3 KEGG hsa04979 Cholesterol metabolism 3/201 50/8135 0.1256 0.8648 0.8543 STARD3/NPC2/MYLIP 3 KEGG hsa04371 Apelin signaling pathway 6/201 139/8135 0.1295 0.8648 0.8543 HDAC4/CALM1/PRKAA1/ADCY2/HDAC5/TFAM 6 KEGG hsa05164 Influenza A 7/201 171/8135 0.1306 0.8648 0.8543 SLC25A6/HLA-DQB1/HLA-DOA/SLC25A5/CYCS/TNFRSF10B/CREBBP 7 KEGG hsa04140 Autophagy - animal 6/201 141/8135 0.136 0.8648 0.8543 PRKAA1/AKT1S1/CTSL/RRAGB/RAB8A/RAB39B 6 KEGG hsa05020 Prion disease 10/201 273/8135 0.1383 0.8648 0.8543 PSMC2/PSMD13/SLC25A6/PSMB6/PSMD3/SDHB/SLC25A5/CYCS/LAMC1/TUBB2A 10 KEGG hsa05320 Autoimmune thyroid disease 3/201 53/8135 0.1425 0.8648 0.8543 PRF1/HLA-DQB1/HLA-DOA 3 KEGG hsa05152 Tuberculosis 7/201 180/8135 0.1576 0.8648 0.8543 CALM1/HLA-DQB1/HLA-DOA/ITGAX/CYCS/IRAK1/CREBBP 7 KEGG hsa05132 Salmonella infection 9/201 249/8135 0.1632 0.8648 0.8543 CASP5/EXOC4/NCKAP1L/CYCS/TNFRSF10B/S100A10/IRAK1/PFN1/TUBB2A 9 KEGG hsa04144 Endocytosis 9/201 251/8135 0.1686 0.8648 0.8543 SNF8/ARF5/CLTB/AP2S1/CHMP7/VPS37D/EHD4/RAB8A/CHMP4B 9 KEGG hsa00030 Pentose phosphate pathway 2/201 30/8135 0.1689 0.8648 0.8543 PRPS1L1/TKTL1 2 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 2/201 30/8135 0.1689 0.8648 0.8543 SHMT1/ACSS1 2 KEGG hsa01523 Antifolate resistance 2/201 30/8135 0.1689 0.8648 0.8543 FPGS/SHMT1 2 KEGG hsa04512 ECM-receptor interaction 4/201 88/8135 0.1727 0.8648 0.8543 LAMC3/COL2A1/LAMC1/COL9A3 4 KEGG hsa04152 AMPK signaling pathway 5/201 120/8135 0.1754 0.8648 0.8543 PRKAA1/AKT1S1/PFKFB1/PPP2R5E/RAB8A 5 KEGG hsa05310 Asthma 2/201 31/8135 0.1778 0.8648 0.8543 HLA-DQB1/HLA-DOA 2 KEGG hsa00640 Propanoate metabolism 2/201 32/8135 0.1867 0.8648 0.8543 ACSS1/DBT 2 KEGG hsa04215 Apoptosis - multiple species 2/201 32/8135 0.1867 0.8648 0.8543 DIABLO/CYCS 2 KEGG hsa04213 Longevity regulating pathway - multiple species 3/201 62/8135 0.1972 0.8648 0.8543 PRKAA1/AKT1S1/ADCY2 3 KEGG hsa04970 Salivary secretion 4/201 93/8135 0.1975 0.8648 0.8543 CALM1/ATP2B4/ATP1B3/ADCY2 4 KEGG hsa05323 Rheumatoid arthritis 4/201 93/8135 0.1975 0.8648 0.8543 LTB/HLA-DQB1/HLA-DOA/CTSL 4 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 15/201 476/8135 0.1983 0.8648 0.8543 PSMC2/CALM1/PSMD13/SLC25A6/PSMB6/PPID/PSMD3/SDHB/SLC25A5/CYCS/RAB8A/TUBB2A/WNT5B/BDNF/RAB39B 15 KEGG hsa00040 Pentose and glucuronate interconversions 2/201 34/8135 0.2048 0.8648 0.8543 DHDH/SORD 2 KEGG hsa04927 Cortisol synthesis and secretion 3/201 65/8135 0.2165 0.8648 0.8543 KCNK2/ADCY2/KCNA4 3 KEGG hsa03015 mRNA surveillance pathway 4/201 97/8135 0.2182 0.8648 0.8543 PPP1CA/PPP2R5E/NCBP1/PPP1CB 4 KEGG hsa04070 Phosphatidylinositol signaling system 4/201 97/8135 0.2182 0.8648 0.8543 CALM1/INPP5E/INPP4A/DGKK 4 KEGG hsa00350 Tyrosine metabolism 2/201 36/8135 0.223 0.8648 0.8543 GSTZ1/AOC3 2 KEGG hsa00760 Nicotinate and nicotinamide metabolism 2/201 36/8135 0.223 0.8648 0.8543 SIRT6/NADK2 2 KEGG hsa04114 Oocyte meiosis 5/201 131/8135 0.2231 0.8648 0.8543 CALM1/PPP1CA/PPP2R5E/ADCY2/PPP1CB 5 KEGG hsa00564 Glycerophospholipid metabolism 4/201 98/8135 0.2234 0.8648 0.8543 GPAT2/AGPAT1/DGKK/MBOAT1 4 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 4/201 98/8135 0.2234 0.8648 0.8543 CALM1/PPP1CA/ADCY2/PPP1CB 4 KEGG hsa04925 Aldosterone synthesis and secretion 4/201 98/8135 0.2234 0.8648 0.8543 CALM1/ATP2B4/ATP1B3/ADCY2 4 KEGG hsa04142 Lysosome 5/201 132/8135 0.2276 0.8648 0.8543 CLTB/CTSZ/CTSL/NPC2/AP3B1 5 KEGG hsa00010 Glycolysis / Gluconeogenesis 3/201 67/8135 0.2295 0.8648 0.8543 HK2/PGK1/ACSS1 3 KEGG hsa05010 Alzheimer disease 12/201 384/8135 0.2406 0.8804 0.8697 PSMC2/CALM1/PSMD13/SLC25A6/PSMB6/PPID/PSMD3/SDHB/SLC25A5/CYCS/TUBB2A/WNT5B 12 KEGG hsa05031 Amphetamine addiction 3/201 69/8135 0.2427 0.8804 0.8697 CALM1/PPP1CA/PPP1CB 3 KEGG hsa04972 Pancreatic secretion 4/201 102/8135 0.2448 0.8804 0.8697 ATP2B4/ATP1B3/ADCY2/RAB8A 4 KEGG hsa05230 Central carbon metabolism in cancer 3/201 70/8135 0.2493 0.8804 0.8697 SIRT6/HK2/GLS2 3 KEGG hsa04910 Insulin signaling pathway 5/201 137/8135 0.2506 0.8804 0.8697 CALM1/PRKAA1/PPP1CA/HK2/PPP1CB 5 KEGG hsa00260 Glycine, serine and threonine metabolism 2/201 40/8135 0.2598 0.9008 0.8898 AOC3/SHMT1 2 KEGG hsa03440 Homologous recombination 2/201 41/8135 0.2691 0.9097 0.8987 RAD51B/BABAM1 2 KEGG hsa04115 p53 signaling pathway 3/201 73/8135 0.2694 0.9097 0.8987 RPRM/CYCS/TNFRSF10B 3 KEGG hsa05014 Amyotrophic lateral sclerosis 11/201 364/8135 0.2889 0.963 0.9513 PSMC2/PSMD13/PSMB6/PSMD3/SDHB/NCBP1/CYCS/RAB8A/PFN1/TUBB2A/RAB39B 11 KEGG hsa05140 Leishmaniasis 3/201 77/8135 0.2965 0.9676 0.9558 HLA-DQB1/HLA-DOA/IRAK1 3 KEGG hsa04612 Antigen processing and presentation 3/201 78/8135 0.3032 0.9676 0.9558 HLA-DQB1/HLA-DOA/CTSL 3 KEGG hsa03022 Basal transcription factors 2/201 45/8135 0.3059 0.9676 0.9558 GTF2IRD1/TAF13 2 KEGG hsa05166 Human T-cell leukemia virus 1 infection 7/201 222/8135 0.3094 0.9676 0.9558 SLC25A6/HLA-DQB1/HLA-DOA/ADCY2/SLC25A5/RANBP1/CREBBP 7 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/201 15/8135 0.3131 0.9676 0.9558 FUT2 1 KEGG hsa05034 Alcoholism 6/201 187/8135 0.3161 0.9676 0.9558 HDAC4/CALM1/PPP1CA/HDAC5/BDNF/PPP1CB 6 KEGG hsa04145 Phagosome 5/201 152/8135 0.3224 0.9676 0.9558 HLA-DQB1/HLA-DOA/CTSL/FCAR/TUBB2A 5 KEGG hsa04973 Carbohydrate digestion and absorption 2/201 47/8135 0.3242 0.9676 0.9558 ATP1B3/HK2 2 KEGG hsa00360 Phenylalanine metabolism 1/201 16/8135 0.3301 0.9676 0.9558 AOC3 1 KEGG hsa04921 Oxytocin signaling pathway 5/201 154/8135 0.3322 0.9676 0.9558 CALM1/PRKAA1/PPP1CA/ADCY2/PPP1CB 5 KEGG hsa04934 Cushing syndrome 5/201 155/8135 0.3371 0.9676 0.9558 WDR5/KCNK2/ADCY2/KCNA4/WNT5B 5 KEGG hsa04722 Neurotrophin signaling pathway 4/201 119/8135 0.3391 0.9676 0.9558 CALM1/IRAK1/ZNF274/BDNF 4 KEGG hsa04150 mTOR signaling pathway 5/201 156/8135 0.3421 0.9676 0.9558 PRKAA1/AKT1S1/RRAGB/LAMTOR4/WNT5B 5 KEGG hsa04672 Intestinal immune network for IgA production 2/201 49/8135 0.3424 0.9676 0.9558 HLA-DQB1/HLA-DOA 2 KEGG hsa04611 Platelet activation 4/201 124/8135 0.3673 0.9832 0.9712 PPP1CA/SNAP23/ADCY2/PPP1CB 4 KEGG hsa04510 Focal adhesion 6/201 201/8135 0.3779 0.9832 0.9712 PPP1CA/LAMC3/COL2A1/LAMC1/PPP1CB/COL9A3 6 KEGG hsa04211 Longevity regulating pathway 3/201 89/8135 0.3779 0.9832 0.9712 PRKAA1/AKT1S1/ADCY2 3 KEGG hsa04727 GABAergic synapse 3/201 89/8135 0.3779 0.9832 0.9712 GABRR3/ADCY2/GLS2 3 KEGG hsa04976 Bile secretion 3/201 89/8135 0.3779 0.9832 0.9712 ATP1B3/ADCY2/ABCB1 3 KEGG hsa04151 PI3K-Akt signaling pathway 10/201 354/8135 0.378 0.9832 0.9712 PRKAA1/LPAR3/LAMC3/PPP2R5E/PKN3/EFNA5/COL2A1/LAMC1/BDNF/COL9A3 10 KEGG hsa04020 Calcium signaling pathway 7/201 240/8135 0.3821 0.9832 0.9712 CALM1/ATP2B4/PLN/SLC25A6/ADCY2/SLC25A5/EDNRB 7 KEGG hsa05415 Diabetic cardiomyopathy 6/201 203/8135 0.3868 0.9832 0.9712 PLN/SLC25A6/PPP1CA/SDHB/SLC25A5/PPP1CB 6 KEGG hsa00100 Steroid biosynthesis 1/201 20/8135 0.3941 0.9832 0.9712 FDFT1 1 KEGG hsa05222 Small cell lung cancer 3/201 92/8135 0.3981 0.9832 0.9712 LAMC3/CYCS/LAMC1 3 KEGG hsa04728 Dopaminergic synapse 4/201 132/8135 0.4123 0.9832 0.9712 CALM1/PPP1CA/PPP2R5E/PPP1CB 4 KEGG hsa04015 Rap1 signaling pathway 6/201 210/8135 0.4179 0.9832 0.9712 CALM1/LPAR3/ADCY2/EVL/EFNA5/PFN1 6 KEGG hsa04270 Vascular smooth muscle contraction 4/201 134/8135 0.4234 0.9832 0.9712 CALM1/PPP1CA/ADCY2/PPP1CB 4 KEGG hsa00220 Arginine biosynthesis 1/201 22/8135 0.4237 0.9832 0.9712 GLS2 1 KEGG hsa05150 Staphylococcus aureus infection 3/201 96/8135 0.4247 0.9832 0.9712 HLA-DQB1/HLA-DOA/FCAR 3 KEGG hsa04330 Notch signaling pathway 2/201 59/8135 0.4304 0.9832 0.9712 DTX4/CREBBP 2 KEGG hsa04713 Circadian entrainment 3/201 97/8135 0.4313 0.9832 0.9712 CALM1/NOS1AP/ADCY2 3 KEGG hsa04978 Mineral absorption 2/201 60/8135 0.4389 0.9832 0.9712 ATP2B4/ATP1B3 2 KEGG hsa00140 Steroid hormone biosynthesis 2/201 61/8135 0.4473 0.9832 0.9712 SRD5A1/AKR1C4 2 KEGG hsa00590 Arachidonic acid metabolism 2/201 61/8135 0.4473 0.9832 0.9712 PTGDS/CYP4F8 2 KEGG hsa05418 Fluid shear stress and atherosclerosis 4/201 139/8135 0.4511 0.9832 0.9712 CALM1/PRKAA1/CTSL/GSTM1 4 KEGG hsa04810 Regulation of actin cytoskeleton 6/201 218/8135 0.4532 0.9832 0.9712 DIAPH2/PPP1CA/NCKAP1L/ITGAX/PFN1/PPP1CB 6 KEGG hsa05146 Amoebiasis 3/201 102/8135 0.4638 0.9832 0.9712 LAMC3/SERPINB6/LAMC1 3 KEGG hsa04974 Protein digestion and absorption 3/201 103/8135 0.4702 0.9832 0.9712 ATP1B3/COL2A1/COL9A3 3 KEGG hsa04064 NF-kappa B signaling pathway 3/201 104/8135 0.4766 0.9832 0.9712 LTB/TNFAIP3/IRAK1 3 KEGG hsa00790 Folate biosynthesis 1/201 26/8135 0.4787 0.9832 0.9712 FPGS 1 KEGG hsa05321 Inflammatory bowel disease 2/201 65/8135 0.4802 0.9832 0.9712 HLA-DQB1/HLA-DOA 2 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/201 27/8135 0.4917 0.9832 0.9712 FUT2 1 KEGG hsa03040 Spliceosome 4/201 147/8135 0.4944 0.9832 0.9712 PRPF31/DHX8/NCBP1/TRA2A 4 KEGG hsa04072 Phospholipase D signaling pathway 4/201 148/8135 0.4998 0.9832 0.9712 AGPAT1/LPAR3/DGKK/ADCY2 4 KEGG hsa04931 Insulin resistance 3/201 108/8135 0.5018 0.9832 0.9712 PRKAA1/PPP1CA/PPP1CB 3 KEGG hsa04514 Cell adhesion molecules 4/201 149/8135 0.5051 0.9832 0.9712 HLA-DQB1/HLA-DOA/VTCN1/PTPRM 4 KEGG hsa04066 HIF-1 signaling pathway 3/201 109/8135 0.508 0.9832 0.9712 HK2/PGK1/CREBBP 3 KEGG hsa04392 Hippo signaling pathway - multiple species 1/201 29/8135 0.5165 0.9832 0.9712 DCHS1 1 KEGG hsa04520 Adherens junction 2/201 71/8135 0.5273 0.9832 0.9712 PTPRM/CREBBP 2 KEGG hsa00020 Citrate cycle (TCA cycle) 1/201 30/8135 0.5285 0.9832 0.9712 SDHB 1 KEGG hsa04724 Glutamatergic synapse 3/201 114/8135 0.5383 0.9832 0.9712 HOMER2/ADCY2/GLS2 3 KEGG hsa05130 Pathogenic Escherichia coli infection 5/201 197/8135 0.5398 0.9832 0.9712 NCKAP1L/CYCS/TNFRSF10B/IRAK1/TUBB2A 5 KEGG hsa00052 Galactose metabolism 1/201 31/8135 0.5402 0.9832 0.9712 HK2 1 KEGG hsa00410 beta-Alanine metabolism 1/201 31/8135 0.5402 0.9832 0.9712 AOC3 1 KEGG hsa04710 Circadian rhythm 1/201 31/8135 0.5402 0.9832 0.9712 PRKAA1 1 KEGG hsa01524 Platinum drug resistance 2/201 73/8135 0.5423 0.9832 0.9712 CYCS/GSTM1 2 KEGG hsa04918 Thyroid hormone synthesis 2/201 75/8135 0.557 0.9832 0.9712 ATP1B3/ADCY2 2 KEGG hsa03410 Base excision repair 1/201 33/8135 0.5628 0.9832 0.9712 MUTYH 1 KEGG hsa04130 SNARE interactions in vesicular transport 1/201 33/8135 0.5628 0.9832 0.9712 SNAP23 1 KEGG hsa05133 Pertussis 2/201 76/8135 0.5642 0.9832 0.9712 CALM1/IRAK1 2 KEGG hsa04935 Growth hormone synthesis, secretion and action 3/201 119/8135 0.5675 0.9832 0.9712 GHRHR/ADCY2/CREBBP 3 KEGG hsa05205 Proteoglycans in cancer 5/201 205/8135 0.5755 0.9832 0.9712 PPP1CA/CTSL/TFAP4/WNT5B/PPP1CB 5 KEGG hsa05131 Shigellosis 6/201 247/8135 0.5755 0.9832 0.9712 AKT1S1/PPID/HK2/RRAGB/CYCS/PFN1 6 KEGG hsa05165 Human papillomavirus infection 8/201 331/8135 0.577 0.9832 0.9712 LAMC3/PPP2R5E/COL2A1/ISG15/LAMC1/WNT5B/CREBBP/COL9A3 8 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 2/201 78/8135 0.5784 0.9832 0.9712 DHDH/GSTM1 2 KEGG hsa04721 Synaptic vesicle cycle 2/201 78/8135 0.5784 0.9832 0.9712 CLTB/AP2S1 2 KEGG hsa04919 Thyroid hormone signaling pathway 3/201 121/8135 0.5789 0.9832 0.9712 PLN/ATP1B3/CREBBP 3 KEGG hsa03018 RNA degradation 2/201 79/8135 0.5854 0.9832 0.9712 TOB1/EXOSC1 2 KEGG hsa00500 Starch and sucrose metabolism 1/201 36/8135 0.5945 0.9832 0.9712 HK2 1 KEGG hsa04310 Wnt signaling pathway 4/201 167/8135 0.5957 0.9832 0.9712 VANGL2/TBL1Y/WNT5B/CREBBP 4 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 1/201 37/8135 0.6046 0.9832 0.9712 GLS2 1 KEGG hsa01250 Biosynthesis of nucleotide sugars 1/201 37/8135 0.6046 0.9832 0.9712 HK2 1 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 1/201 37/8135 0.6046 0.9832 0.9712 ATP1B3 1 KEGG hsa04141 Protein processing in endoplasmic reticulum 4/201 171/8135 0.6144 0.9832 0.9712 RPN2/ERP29/EDEM2/RPN1 4 KEGG hsa00230 Purine metabolism 3/201 128/8135 0.6173 0.9832 0.9712 PDE6D/PRPS1L1/ADCY2 3 KEGG hsa04926 Relaxin signaling pathway 3/201 129/8135 0.6225 0.9832 0.9712 RLN1/ADCY2/EDNRB 3 KEGG hsa04610 Complement and coagulation cascades 2/201 85/8135 0.6254 0.9832 0.9712 VSIG4/ITGAX 2 KEGG hsa04911 Insulin secretion 2/201 86/8135 0.6318 0.9832 0.9712 ATP1B3/ADCY2 2 KEGG hsa04068 FoxO signaling pathway 3/201 131/8135 0.6329 0.9832 0.9712 PRKAA1/HOMER2/CREBBP 3 KEGG hsa04650 Natural killer cell mediated cytotoxicity 3/201 131/8135 0.6329 0.9832 0.9712 PRF1/TNFRSF10B/RAET1E 3 KEGG hsa05033 Nicotine addiction 1/201 40/8135 0.6333 0.9832 0.9712 GABRR3 1 KEGG hsa04540 Gap junction 2/201 88/8135 0.6443 0.9832 0.9712 ADCY2/TUBB2A 2 KEGG hsa04080 Neuroactive ligand-receptor interaction 8/201 353/8135 0.65 0.9832 0.9712 GHRHR/LPAR3/RLN1/TAC3/GABRR3/P2RY10/EDNRB/GPHA2 8 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 5/201 223/8135 0.6502 0.9832 0.9712 SLC25A6/SDHB/SLC25A5/AKR1C4/GSTM1 5 KEGG hsa05206 MicroRNAs in cancer 7/201 310/8135 0.6503 0.9832 0.9712 HDAC4/TRIM71/EFNA5/HDAC5/GLS2/ABCB1/CREBBP 7 KEGG hsa04975 Fat digestion and absorption 1/201 43/8135 0.6599 0.9832 0.9712 AGPAT1 1 KEGG hsa05032 Morphine addiction 2/201 91/8135 0.6624 0.9832 0.9712 GABRR3/ADCY2 2 KEGG hsa04915 Estrogen signaling pathway 3/201 138/8135 0.6678 0.9832 0.9712 CALM1/ADCY2/ESR2 3 KEGG hsa04658 Th1 and Th2 cell differentiation 2/201 92/8135 0.6683 0.9832 0.9712 HLA-DQB1/HLA-DOA 2 KEGG hsa05162 Measles 3/201 139/8135 0.6726 0.9832 0.9712 TNFAIP3/CYCS/IRAK1 3 KEGG hsa04912 GnRH signaling pathway 2/201 93/8135 0.6741 0.9832 0.9712 CALM1/ADCY2 2 KEGG hsa02010 ABC transporters 1/201 45/8135 0.6766 0.9832 0.9712 ABCB1 1 KEGG hsa04714 Thermogenesis 5/201 232/8135 0.6843 0.9832 0.9712 PRKAA1/SIRT6/AKT1S1/SDHB/ADCY2 5 KEGG hsa04930 Type II diabetes mellitus 1/201 46/8135 0.6847 0.9832 0.9712 HK2 1 KEGG hsa04936 Alcoholic liver disease 3/201 142/8135 0.6866 0.9832 0.9712 PRKAA1/IRAK1/TRA2A 3 KEGG hsa05414 Dilated cardiomyopathy 2/201 96/8135 0.691 0.9832 0.9712 PLN/ADCY2 2 KEGG hsa00620 Pyruvate metabolism 1/201 47/8135 0.6925 0.9832 0.9712 ACSS1 1 KEGG hsa04613 Neutrophil extracellular trap formation 4/201 190/8135 0.6959 0.9832 0.9712 HDAC4/SLC25A6/SLC25A5/HDAC5 4 KEGG hsa00280 Valine, leucine and isoleucine degradation 1/201 48/8135 0.7001 0.9832 0.9712 DBT 1 KEGG hsa01522 Endocrine resistance 2/201 98/8135 0.7018 0.9832 0.9712 ADCY2/ESR2 2 KEGG hsa04640 Hematopoietic cell lineage 2/201 99/8135 0.7071 0.9832 0.9712 HLA-DQB1/HLA-DOA 2 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 1/201 49/8135 0.7076 0.9832 0.9712 HK2 1 KEGG hsa05030 Cocaine addiction 1/201 49/8135 0.7076 0.9832 0.9712 BDNF 1 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 2/201 100/8135 0.7124 0.9832 0.9712 ACKR4/TNFRSF10B 2 KEGG hsa05110 Vibrio cholerae infection 1/201 50/8135 0.7149 0.9832 0.9712 KDELR1 1 KEGG hsa00330 Arginine and proline metabolism 1/201 51/8135 0.7219 0.9832 0.9712 CKM 1 KEGG hsa04913 Ovarian steroidogenesis 1/201 51/8135 0.7219 0.9832 0.9712 ADCY2 1 KEGG hsa04620 Toll-like receptor signaling pathway 2/201 104/8135 0.7325 0.9832 0.9712 IRF5/IRAK1 2 KEGG hsa01240 Biosynthesis of cofactors 3/201 153/8135 0.7343 0.9832 0.9712 FPGS/SHMT1/NADK2 3 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 2/201 106/8135 0.7421 0.9832 0.9712 ADCY2/MMP25 2 KEGG hsa03460 Fanconi anemia pathway 1/201 54/8135 0.7422 0.9832 0.9712 FANCG 1 KEGG hsa04932 Non-alcoholic fatty liver disease 3/201 155/8135 0.7423 0.9832 0.9712 PRKAA1/SDHB/CYCS 3 KEGG hsa05203 Viral carcinogenesis 4/201 204/8135 0.7477 0.9832 0.9712 HDAC4/HDAC5/RANBP1/CREBBP 4 KEGG hsa04390 Hippo signaling pathway 3/201 157/8135 0.7501 0.9832 0.9712 PPP1CA/WNT5B/PPP1CB 3 KEGG hsa03013 Nucleocytoplasmic transport 2/201 108/8135 0.7515 0.9832 0.9712 AAAS/NCBP1 2 KEGG hsa04659 Th17 cell differentiation 2/201 108/8135 0.7515 0.9832 0.9712 HLA-DQB1/HLA-DOA 2 KEGG hsa04340 Hedgehog signaling pathway 1/201 56/8135 0.7548 0.9832 0.9712 HHATL 1 KEGG hsa04923 Regulation of lipolysis in adipocytes 1/201 56/8135 0.7548 0.9832 0.9712 ADCY2 1 KEGG hsa05134 Legionellosis 1/201 57/8135 0.7609 0.9832 0.9712 CYCS 1 KEGG hsa00240 Pyrimidine metabolism 1/201 58/8135 0.7669 0.9832 0.9712 DCTD 1 KEGG hsa00480 Glutathione metabolism 1/201 58/8135 0.7669 0.9832 0.9712 GSTM1 1 KEGG hsa05161 Hepatitis B 3/201 162/8135 0.7689 0.9832 0.9712 CYCS/IRAK1/CREBBP 3 KEGG hsa05170 Human immunodeficiency virus 1 infection 4/201 212/8135 0.7741 0.9832 0.9712 CALM1/CYCS/BST2/IRAK1 4 KEGG hsa05417 Lipid and atherosclerosis 4/201 215/8135 0.7834 0.9832 0.9712 CALM1/CYCS/TNFRSF10B/IRAK1 4 KEGG hsa05225 Hepatocellular carcinoma 3/201 168/8135 0.7899 0.9832 0.9712 PBRM1/WNT5B/GSTM1 3 KEGG hsa00310 Lysine degradation 1/201 63/8135 0.7945 0.9832 0.9712 NSD1 1 KEGG hsa04623 Cytosolic DNA-sensing pathway 1/201 63/8135 0.7945 0.9832 0.9712 AIM2 1 KEGG hsa05217 Basal cell carcinoma 1/201 63/8135 0.7945 0.9832 0.9712 WNT5B 1 KEGG hsa04071 Sphingolipid signaling pathway 2/201 119/8135 0.7977 0.9832 0.9712 PPP2R5E/NSMAF 2 KEGG hsa04929 GnRH secretion 1/201 64/8135 0.7996 0.9832 0.9712 ESR2 1 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/201 66/8135 0.8095 0.9832 0.9712 RARS2 1 KEGG hsa00830 Retinol metabolism 1/201 68/8135 0.8188 0.9832 0.9712 CYP27C1 1 KEGG hsa04920 Adipocytokine signaling pathway 1/201 69/8135 0.8234 0.9832 0.9712 PRKAA1 1 KEGG hsa04924 Renin secretion 1/201 69/8135 0.8234 0.9832 0.9712 CALM1 1 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 1/201 69/8135 0.8234 0.9832 0.9712 GSTM1 1 KEGG hsa05211 Renal cell carcinoma 1/201 69/8135 0.8234 0.9832 0.9712 CREBBP 1 KEGG hsa04622 RIG-I-like receptor signaling pathway 1/201 70/8135 0.8278 0.9832 0.9712 ISG15 1 KEGG hsa04917 Prolactin signaling pathway 1/201 70/8135 0.8278 0.9832 0.9712 ESR2 1 KEGG hsa00982 Drug metabolism - cytochrome P450 1/201 72/8135 0.8362 0.9832 0.9712 GSTM1 1 KEGG hsa04621 NOD-like receptor signaling pathway 3/201 184/8135 0.8382 0.9832 0.9712 CASP5/AIM2/TNFAIP3 3 KEGG hsa05214 Glioma 1/201 75/8135 0.8482 0.9832 0.9712 CALM1 1 KEGG hsa00190 Oxidative phosphorylation 2/201 134/8135 0.8485 0.9832 0.9712 SDHB/CYCS 2 KEGG hsa05322 Systemic lupus erythematosus 2/201 136/8135 0.8543 0.9832 0.9712 HLA-DQB1/HLA-DOA 2 KEGG hsa05100 Bacterial invasion of epithelial cells 1/201 77/8135 0.8557 0.9832 0.9712 CLTB 1 KEGG hsa04060 Cytokine-cytokine receptor interaction 5/201 295/8135 0.8599 0.9832 0.9712 LTB/TNFRSF11B/ACKR4/TNFRSF10B/IL36G 5 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 3/201 194/8135 0.8633 0.9832 0.9712 CALM1/CYCS/CREBBP 3 KEGG hsa00983 Drug metabolism - other enzymes 1/201 80/8135 0.8662 0.9832 0.9712 GSTM1 1 KEGG hsa04120 Ubiquitin mediated proteolysis 2/201 142/8135 0.8706 0.9832 0.9712 RHOBTB1/RHOBTB2 2 KEGG hsa04146 Peroxisome 1/201 82/8135 0.8728 0.9832 0.9712 ACOT8 1 KEGG hsa01232 Nucleotide metabolism 1/201 85/8135 0.8821 0.9832 0.9712 DCTD 1 KEGG hsa05224 Breast cancer 2/201 147/8135 0.8828 0.9832 0.9712 WNT5B/ESR2 2 KEGG hsa05210 Colorectal cancer 1/201 86/8135 0.885 0.9832 0.9712 CYCS 1 KEGG hsa04723 Retrograde endocannabinoid signaling 2/201 148/8135 0.8852 0.9832 0.9712 GABRR3/ADCY2 2 KEGG hsa05226 Gastric cancer 2/201 149/8135 0.8874 0.9832 0.9712 ABCB1/WNT5B 2 KEGG hsa04260 Cardiac muscle contraction 1/201 87/8135 0.8879 0.9832 0.9712 ATP1B3 1 KEGG hsa05410 Hypertrophic cardiomyopathy 1/201 90/8135 0.8961 0.9832 0.9712 PRKAA1 1 KEGG hsa05207 Chemical carcinogenesis - receptor activation 3/201 212/8135 0.9 0.9832 0.9712 ADCY2/ESR2/GSTM1 3 KEGG hsa04350 TGF-beta signaling pathway 1/201 94/8135 0.9061 0.9832 0.9712 CREBBP 1 KEGG hsa04657 IL-17 signaling pathway 1/201 94/8135 0.9061 0.9832 0.9712 TNFAIP3 1 KEGG hsa05215 Prostate cancer 1/201 97/8135 0.913 0.9832 0.9712 CREBBP 1 KEGG hsa05231 Choline metabolism in cancer 1/201 98/8135 0.9151 0.9832 0.9712 DGKK 1 KEGG hsa05163 Human cytomegalovirus infection 3/201 225/8135 0.9207 0.9832 0.9712 CALM1/ADCY2/CYCS 3 KEGG hsa04914 Progesterone-mediated oocyte maturation 1/201 102/8135 0.9233 0.9832 0.9712 ADCY2 1 KEGG hsa05142 Chagas disease 1/201 102/8135 0.9233 0.9832 0.9712 IRAK1 1 KEGG hsa04530 Tight junction 2/201 169/8135 0.9251 0.9832 0.9712 PRKAA1/RAB8A 2 KEGG hsa04625 C-type lectin receptor signaling pathway 1/201 104/8135 0.9271 0.9832 0.9712 CALM1 1 KEGG hsa04014 Ras signaling pathway 3/201 232/8135 0.9302 0.9832 0.9712 CALM1/EFNA5/BDNF 3 KEGG hsa05171 Coronavirus disease - COVID-19 3/201 232/8135 0.9302 0.9832 0.9712 ISG15/IRAK1/RPS29 3 KEGG hsa04668 TNF signaling pathway 1/201 112/8135 0.9405 0.9845 0.9725 TNFAIP3 1 KEGG hsa04725 Cholinergic synapse 1/201 113/8135 0.942 0.9845 0.9725 ADCY2 1 KEGG hsa04360 Axon guidance 2/201 182/8135 0.9428 0.9845 0.9725 EFNA5/WNT5B 2 KEGG hsa04110 Cell cycle 1/201 126/8135 0.9583 0.9948 0.9827 CREBBP 1 KEGG hsa04380 Osteoclast differentiation 1/201 128/8135 0.9604 0.9948 0.9827 TNFRSF11B 1 KEGG hsa05135 Yersinia infection 1/201 137/8135 0.9685 0.9948 0.9827 IRAK1 1 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 1/201 143/8135 0.9729 0.9948 0.9827 WNT5B 1 KEGG hsa04010 MAPK signaling pathway 3/201 294/8135 0.9786 0.9948 0.9827 EFNA5/IRAK1/BDNF 3 KEGG hsa05160 Hepatitis C 1/201 157/8135 0.9811 0.9948 0.9827 CYCS 1 KEGG hsa03010 Ribosome 1/201 158/8135 0.9815 0.9948 0.9827 RPS29 1 KEGG hsa04630 JAK-STAT signaling pathway 1/201 162/8135 0.9833 0.9948 0.9827 CREBBP 1 KEGG hsa04062 Chemokine signaling pathway 1/201 192/8135 0.9923 0.9958 0.9837 ADCY2 1 KEGG hsa05202 Transcriptional misregulation in cancer 1/201 193/8135 0.9925 0.9958 0.9837 LMO2 1 KEGG hsa04740 Olfactory transduction 4/201 440/8135 0.9958 0.9958 0.9837 CALM1/CNGB1/OR4D1/OR1D5 4