ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05010 Alzheimer disease 88/1171 384/8135 3.107e-06 0.001035 0.0007948 NDUFB3/CALM3/DDIT3/SLC25A5/COX7C/NDUFA1/COX6A1/VDAC1/CALM1/COX7A2/PIK3R4/UQCRQ/IKBKB/PSMD7/CSNK2A2/MAP2K1/COX7B/PSMA4/BECN1/CASP8/NDUFB6/NDUFS5/NDUFA2/PSMD13/COX6C/IKBKG/CDK5R1/PPP3CC/ITPR3/AXIN2/CSNK1A1/PSMA6/CSNK1E/PSMB2/NDUFS4/NDUFA6/UQCRB/GSK3B/PSMB1/NDUFA4/TUBB8/NCSTN/WIPI2/MAPK9/PIK3CB/FADD/PSMB7/CSNK2B/EIF2AK2/NDUFS7/TUBA1C/PSMA3/PSMC4/PIK3R2/SLC39A6/AXIN1/TNF/SLC39A11/NDUFV1/SLC39A1/NDUFS8/PSEN2/COX6B1/FZD9/COX4I2/TUBA1B/PSMD8/WNT10A/IL1B/PLCB1/APH1B/SLC39A9/COX5A/AGER/KIF5B/XBP1/COX5B/GAPDH/PSMA1/PSENEN/UQCRFS1/FRAT1/WNT1/FZD6/RTN4/PIK3R3/ITPR2/PSMA2 88 KEGG hsa04660 T cell receptor signaling pathway 32/1171 104/8135 1.375e-05 0.001512 0.001161 CARD11/LCP2/PRKCQ/IKBKB/MAP2K1/MAPK12/FYN/PTPRC/CD247/CD40LG/CTLA4/NFATC3/IKBKG/PPP3CC/GSK3B/MAP3K8/CD4/CD8A/MAPK9/PAK4/PIK3CB/ITK/PAK1/CD3E/PIK3R2/TNF/NFKBIE/PLCG1/NCK1/IFNG/MAPK13/PIK3R3 32 KEGG hsa05020 Prion disease 65/1171 273/8135 1.74e-05 0.001512 0.001161 NDUFB3/DDIT3/SLC25A5/COX7C/NDUFA1/COX6A1/VDAC1/CREB1/COX7A2/UQCRQ/NCF4/PSMD7/CSNK2A2/COX7B/PSMA4/PRNP/MAPK12/FYN/NDUFB6/NDUFS5/NDUFA2/PSMD13/COX6C/PPP3CC/ITPR3/RAC2/PSMA6/PSMB2/NDUFS4/ATF2/NDUFA6/UQCRB/GSK3B/PSMB1/NDUFA4/TUBB8/MAPK9/EGR1/PIK3CB/PSMB7/CSNK2B/NDUFS7/TUBA1C/PSMA3/PSMC4/PIK3R2/TNF/NDUFV1/NDUFS8/HSPA6/COX6B1/COX4I2/TUBA1B/PSMD8/IL1B/COX5A/KIF5B/COX5B/PSMA1/UQCRFS1/MAPK13/CCL5/PIK3R3/ITPR2/PSMA2 65 KEGG hsa04658 Th1 and Th2 cell differentiation 29/1171 92/8135 2.073e-05 0.001512 0.001161 RUNX3/IL2RB/JAK1/GATA3/HLA-DPA1/PRKCQ/IKBKB/HLA-DMA/MAML2/MAPK12/CD247/IL12RB1/NFATC3/HLA-DRB4/IKBKG/PPP3CC/HLA-DPB1/CD4/MAPK9/CD3E/HLA-DMB/IL12RB2/NFKBIE/PLCG1/IFNG/MAF/DLL1/HLA-DOA/MAPK13 29 KEGG hsa03015 mRNA surveillance pathway 30/1171 97/8135 2.27e-05 0.001512 0.001161 EIF4A3/SRRM1/RNPS1/PPP2R3C/DAZAP1/PPP2R5A/MAGOH/SMG5/PPP2CB/WDR33/GSPT2/CPSF4/CSTF2/DDX19A/PPP2R1A/PPP2R2A/CPSF3/NXF1/CPSF1/PABPC1/CSTF3/RNMT/PPP2R3A/CASC3/NCBP2/SMG7/DDX19B/NXT1/CPSF2/PPP1CA 30 KEGG hsa00280 Valine, leucine and isoleucine degradation 18/1171 48/8135 6.178e-05 0.003429 0.002634 ALDH9A1/HADH/ECHS1/HMGCL/HIBADH/BCAT2/ALDH3A2/PCCA/ALDH6A1/BCKDHB/OXCT1/PCCB/MCCC1/IVD/HIBCH/OXCT2/ACADM/BCKDHA 18 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 27/1171 89/8135 8.349e-05 0.003972 0.003051 JAK1/PRKCQ/IKBKB/TICAM1/CSNK2A2/MAP2K1/MAPK12/CD247/NFATC3/IKBKG/PPP3CC/CD4/TLR2/PIK3CB/CSNK2B/BATF/TLR4/CD3E/PIK3R2/NFKBIE/PTEN/PLCG1/IFNG/MAP3K3/EML4/MAPK13/PIK3R3 27 KEGG hsa04932 Non-alcoholic fatty liver disease 40/1171 155/8135 0.0001165 0.004809 0.003694 NDUFB3/DDIT3/COX7C/NDUFA1/COX6A1/COX7A2/FASLG/UQCRQ/IKBKB/COX7B/MAPK12/CASP8/NDUFB6/NDUFS5/NDUFA2/COX6C/PRKAG2/NDUFS4/NDUFA6/UQCRB/GSK3B/NDUFA4/MAPK9/PIK3CB/NDUFS7/PIK3R2/CEBPA/MLXIP/TNF/NDUFV1/NDUFS8/COX6B1/COX4I2/IL1B/COX5A/XBP1/COX5B/UQCRFS1/MAPK13/PIK3R3 40 KEGG hsa05415 Diabetic cardiomyopathy 49/1171 203/8135 0.00013 0.004809 0.003694 PDHB/PARP1/NDUFB3/PDHA1/SLC25A5/COX7C/NDUFA1/COX6A1/VDAC1/MMP9/COX7A2/UQCRQ/NCF4/COX7B/MAPK12/NDUFB6/NDUFS5/NDUFA2/COX6C/RAC2/NDUFS4/NDUFA6/UQCRB/TGFBR1/GSK3B/CPT2/NDUFA4/MAPK9/PIK3CB/PDK2/NDUFS7/PIK3R2/PDK4/NDUFV1/NDUFS8/PTEN/G6PD/COX6B1/COX4I2/PLCB1/COX5A/PPP1CA/AGER/COX5B/SMAD3/GAPDH/UQCRFS1/MAPK13/PIK3R3 49 KEGG hsa05012 Parkinson disease 60/1171 266/8135 0.0001863 0.006184 0.00475 NDUFB3/CALM3/UBE2G1/DDIT3/SLC25A5/COX7C/NDUFA1/TXN/COX6A1/VDAC1/CALM1/COX7A2/UQCRQ/PSMD7/COX7B/PSMA4/HTRA2/NDUFB6/NDUFS5/NDUFA2/PSMD13/COX6C/ITPR3/PSMA6/PSMB2/NDUFS4/NDUFA6/UQCRB/PSMB1/NDUFA4/TUBB8/MAPK9/PSMB7/NDUFS7/TUBA1C/TRAP1/PSMA3/PSMC4/SLC39A6/TXN2/SLC39A11/NDUFV1/SLC18A2/SLC39A1/NDUFS8/MAOA/COX6B1/COX4I2/TUBA1B/PSMD8/PLCG1/SLC39A9/COX5A/KIF5B/XBP1/COX5B/PSMA1/UQCRFS1/ITPR2/PSMA2 60 KEGG hsa03013 Nucleocytoplasmic transport 30/1171 108/8135 0.0002043 0.006184 0.00475 NUP62/NUP93/NUP214/EIF4A3/SRRM1/SUMO3/RNPS1/TNPO1/RANGAP1/XPO5/MAGOH/NUP153/NUP107/DDX19A/NUP85/RAN/TNPO2/NXF1/RAE1/XPO4/CASC3/NCBP2/NUP160/DDX19B/TNPO3/AAAS/THOC1/NXT1/KPNA1/THOC3 30 KEGG hsa05132 Salmonella infection 56/1171 249/8135 0.0003273 0.009083 0.006977 LY96/RAB9A/STX10/TLR5/ACTG1/TXN/PFN1/DYNLT1/DYNC1H1/IKBKB/MAP2K1/ARF1/TNFSF10/MAPK12/CASP8/PTPRC/IKBKG/LEF1/TLR2/ARPC3/TUBB8/MAPK9/ANXA2/HSP90B1/HSP90AB1/PIK3CB/ROCK2/FADD/FLNB/TUBA1C/DNM2/TLR4/RRAS/PAK1/EXOC2/ACTR1B/TNF/TCF7L2/TXN2/ELMO2/VPS18/PLEKHM2/TUBA1B/ACTR2/MYC/IL1B/KIF5B/BAK1/ARPC5L/ARF6/GAPDH/CASP5/MYL7/NOD1/KPNA1/MAPK13 56 KEGG hsa03010 Ribosome 39/1171 158/8135 0.0003803 0.009742 0.007483 RPLP2/MRPL33/MRPS18C/RPL31/RPL39/RPS24/RPL26/RPS27L/RPL41/MRPL22/RPS21/RPL34/RPS27/RPS17/RPS15A/RPL23/RPL38/RPL9/MRPS6/MRPL16/RPL26L1/RPL19/RPL11/RPL3L/MRPL21/RPL7/RPL35A/MRPL13/RPS7/RPS29/RPL27/MRPL15/MRPL18/RPL28/MRPL36/MRPS9/RPS10/RPS19/RPS4X 39 KEGG hsa04659 Th17 cell differentiation 29/1171 108/8135 0.0004825 0.01148 0.008816 IL2RB/JAK1/GATA3/HLA-DPA1/PRKCQ/IKBKB/IL27RA/HLA-DMA/MAPK12/CD247/IL12RB1/NFATC3/HLA-DRB4/IKBKG/PPP3CC/HLA-DPB1/TGFBR1/CD4/MAPK9/HSP90AB1/CD3E/HLA-DMB/NFKBIE/PLCG1/IFNG/IL1B/HLA-DOA/SMAD3/MAPK13 29 KEGG hsa03040 Spliceosome 36/1171 147/8135 0.000735 0.01632 0.01253 PCBP1/EIF4A3/BUD31/U2AF2/SF3B2/LSM3/SNRPB/DDX23/PRPF8/MAGOH/SF3B4/DHX38/PRPF4/ZMAT2/SF3B3/AQR/SNRPG/PRPF19/SF3A3/SF3A2/SLU7/DDX5/LSM2/XAB2/CTNNBL1/NCBP2/SNRPD2/THOC1/RBM22/SF3B5/SF3A1/CCDC12/HSPA6/PRPF38A/SNRPA1/THOC3 36 KEGG hsa04612 Antigen processing and presentation 22/1171 78/8135 0.00111 0.02161 0.0166 CD74/CREB1/HLA-DPA1/HLA-DMA/RFX5/RFXAP/HLA-DRB4/HLA-DPB1/CD4/CD8A/LGMN/HSP90AB1/TAP1/TAP2/HLA-DMB/TNF/KLRD1/HSPA6/KLRC1/IFNG/HLA-DOA/PSME2 22 KEGG hsa05323 Rheumatoid arthritis 25/1171 93/8135 0.001133 0.02161 0.0166 ATP6V1D/ATP6V0E1/ATP6V0E2/HLA-DPA1/HLA-DMA/CTLA4/HLA-DRB4/ATP6V1E2/HLA-DPB1/TLR2/TNFSF13B/TLR4/ICAM1/CXCL12/HLA-DMB/TNF/IFNG/ITGAL/IL1B/HLA-DOA/ANGPT1/ATP6V1B1/ATP6V1G3/ATP6V1E1/CCL5 25 KEGG hsa05166 Human T-cell leukemia virus 1 infection 49/1171 222/8135 0.001168 0.02161 0.0166 IL2RB/SRF/TRRAP/SLC25A5/ETS1/ZFP36/VDAC1/CREB1/JAK1/HLA-DPA1/IKBKB/ADCY7/MAP2K1/HLA-DMA/ANAPC5/ANAPC1/TBP/ADCY4/NFATC3/HLA-DRB4/IKBKG/CDK2/PPP3CC/HLA-DPB1/ATF2/TGFBR1/CD4/RAN/MAPK9/EGR1/PIK3CB/IL1R2/CD3E/PIK3R2/ICAM1/HLA-DMB/TNF/TCF3/CDC23/PTEN/MYC/ITGAL/RB1/MAP3K3/HLA-DOA/SMAD3/ADCY9/ATM/PIK3R3 49 KEGG hsa04625 C-type lectin receptor signaling pathway 27/1171 104/8135 0.001298 0.02182 0.01676 CALM3/CLEC4D/CALM1/IKBKB/IRF1/MAPK12/CASP8/NFATC3/IKBKG/PPP3CC/ITPR3/MAPK9/PIK3CB/CLEC7A/RRAS/PAK1/PIK3R2/TNF/CYLD/MRAS/IL1B/CARD9/CLEC4E/MAPKAPK2/MAPK13/PIK3R3/ITPR2 27 KEGG hsa05170 Human immunodeficiency virus 1 infection 47/1171 212/8135 0.001323 0.02182 0.01676 GNB1/CALM3/CRKL/CALM1/CFL1/FASLG/IKBKB/MAP2K1/RBX1/MAPK12/CASP8/AP1M1/CD247/NFATC3/IKBKG/PPP3CC/ITPR3/RAC2/CD4/CUL1/TLR2/AP1B1/MAPK9/PAK4/PIK3CB/FADD/TAP1/TLR4/PAK1/CD3E/PIK3R2/TAP2/CUL4A/TNF/TNFRSF1B/SAMHD1/GNG11/PLCG1/GNG5/RNF7/GNB4/BAK1/IFNA2/ATM/MAPK13/PIK3R3/ITPR2 47 KEGG hsa03050 Proteasome 15/1171 46/8135 0.001376 0.02182 0.01676 PSMB10/PSMD7/PSMA4/PSMD13/PSMA6/PSMB2/PSMB1/PSMB7/PSMA3/PSMC4/PSMD8/IFNG/PSMA1/PSMA2/PSME2 15 KEGG hsa05332 Graft-versus-host disease 14/1171 42/8135 0.001553 0.0235 0.01805 HLA-DPA1/FASLG/HLA-DMA/HLA-DRB4/PRF1/HLA-DPB1/HLA-DMB/TNF/KLRD1/KLRC1/IFNG/IL1B/HLA-DOA/GZMB 14 KEGG hsa05164 Influenza A 39/1171 171/8135 0.001919 0.02779 0.02135 SLC25A5/ACTG1/VDAC1/JAK1/HLA-DPA1/FASLG/IKBKB/TICAM1/MAP2K1/HLA-DMA/TNFSF10/CASP8/HLA-DRB4/CPSF4/IKBKG/HLA-DPB1/PIK3CB/NXF1/RAE1/FADD/TRIM25/EIF2AK2/TLR4/PIK3R2/ICAM1/MX2/HLA-DMB/TNF/IFNG/IL1B/NXT1/HLA-DOA/BAK1/IFNA2/DNAJC3/KPNA1/CCL5/IFNAR1/PIK3R3 39 KEGG hsa05169 Epstein-Barr virus infection 44/1171 202/8135 0.002664 0.03595 0.02762 RUNX3/HDAC1/SIN3A/JAK1/HLA-DPA1/CR2/IKBKB/PSMD7/HLA-DMA/MAPK12/CASP8/CD247/PSMD13/HLA-DRB4/IKBKG/CDK2/HLA-DPB1/TLR2/CD58/MAPK9/ENTPD1/PIK3CB/CDKN1B/FADD/EIF2AK2/TAP1/PSMC4/CD3E/PIK3R2/ICAM1/TAP2/HLA-DMB/TNF/NFKBIE/PSMD8/MYC/ITGAL/RB1/HLA-DOA/BAK1/IFNA2/MAPK13/IFNAR1/PIK3R3 44 KEGG hsa04145 Phagosome 35/1171 152/8135 0.002699 0.03595 0.02762 ATP6V1D/ATP6V0E1/ACTG1/ATP6V0E2/HLA-DPA1/DYNC1H1/NCF4/HLA-DMA/VAMP3/SFTPD/LAMP1/HLA-DRB4/SCARB1/ATP6V1E2/HLA-DPB1/TLR2/SEC22B/TUBB8/HGS/THBS1/CLEC7A/TUBA1C/TAP1/TLR4/MPO/TAP2/HLA-DMB/OLR1/TUBA1B/HLA-DOA/ATP6V1B1/ATP6V1G3/ATP6V1E1/CORO1A/SEC61B 35 KEGG hsa04210 Apoptosis 32/1171 136/8135 0.002813 0.03603 0.02768 PARP1/DDIT3/ACTG1/DFFB/FASLG/IKBKB/MAP2K1/CASP2/CTSC/TNFSF10/HTRA2/CTSW/CASP8/LMNB2/IKBKG/ITPR3/PRF1/PARP2/MAPK9/PIK3CB/FADD/TUBA1C/PIK3R2/TNF/DFFA/TUBA1B/BAK1/ATM/GZMB/SPTAN1/PIK3R3/ITPR2 32 KEGG hsa04657 IL-17 signaling pathway 24/1171 94/8135 0.002986 0.03683 0.02829 S100A8/S100A9/MMP9/IKBKB/IL17RA/ANAPC5/MAPK12/CASP8/IKBKG/GSK3B/MAPK9/MAPK7/HSP90B1/HSP90AB1/FADD/LCN2/TNF/CEBPB/IL25/IFNG/IL1B/ELAVL1/S100A7/MAPK13 24 KEGG hsa00640 Propanoate metabolism 11/1171 32/8135 0.003706 0.04407 0.03385 ECHS1/PCCA/ALDH6A1/BCKDHB/MLYCD/PCCB/HIBCH/ACACB/BCKDHA/ACOX3/ACSS1 11 KEGG hsa05418 Fluid shear stress and atherosclerosis 32/1171 139/8135 0.004028 0.04626 0.03553 KLF2/CALM3/SUMO3/ACTG1/TXN/GSTO1/CALM1/MMP9/IKBKB/GSTP1/MAPK12/SELE/IKBKG/RAC2/THBD/MAPK9/MAPK7/HSP90B1/HSP90AB1/PIK3CB/MGST3/IL1R2/PIK3R2/ICAM1/TNF/GSTO2/TXN2/IFNG/IL1B/GSTM4/MAPK13/PIK3R3 32 KEGG hsa00190 Oxidative phosphorylation 31/1171 134/8135 0.004259 0.04727 0.03631 NDUFB3/ATP6V1D/COX7C/ATP6V0E1/NDUFA1/COX6A1/ATP6V0E2/COX7A2/UQCRQ/COX7B/NDUFB6/NDUFS5/NDUFA2/COX6C/ATP6V1E2/NDUFS4/NDUFA6/UQCRB/NDUFA4/NDUFS7/NDUFV1/NDUFS8/COX6B1/COX4I2/COX5A/ATP6V1B1/COX5B/UQCRFS1/ATP6V1G3/ATP6V1E1/COX17 31 KEGG hsa05142 Chagas disease 25/1171 102/8135 0.004436 0.04765 0.0366 FASLG/IKBKB/TICAM1/MAPK12/CASP8/CD247/PPP2CB/IKBKG/PPP2R1A/TGFBR1/PPP2R2A/TLR2/MAPK9/PIK3CB/FADD/TLR4/CD3E/PIK3R2/TNF/IFNG/IL1B/PLCB1/MAPK13/CCL5/PIK3R3 25 KEGG hsa05330 Allograft rejection 12/1171 38/8135 0.005439 0.0566 0.04347 HLA-DPA1/FASLG/HLA-DMA/CD40LG/HLA-DRB4/PRF1/HLA-DPB1/HLA-DMB/TNF/IFNG/HLA-DOA/GZMB 12 KEGG hsa04940 Type I diabetes mellitus 13/1171 43/8135 0.005866 0.05772 0.04434 HLA-DPA1/FASLG/HLA-DMA/HLA-DRB4/PRF1/HLA-DPB1/HLA-DMB/TNF/IFNG/IL1B/HLA-DOA/GZMB/ICA1 13 KEGG hsa05135 Yersinia infection 31/1171 137/8135 0.006012 0.05772 0.04434 LCP2/CRKL/ACTG1/IKBKB/TICAM1/MAP2K1/MAPK12/NFATC3/ITGA4/IKBKG/RAC2/GSK3B/CD4/ARPC3/CD8A/MAPK9/WIPF2/PIK3CB/ROCK2/WASF2/TLR4/PIK3R2/TNF/ELMO2/PLCG1/ACTR2/IL1B/ARPC5L/ARF6/MAPK13/PIK3R3 31 KEGG hsa04640 Hematopoietic cell lineage 24/1171 99/8135 0.006066 0.05772 0.04434 HLA-DPA1/CR2/CD37/HLA-DMA/CSF1R/CD9/HLA-DRB4/ITGA4/CD5/HLA-DPB1/CD7/CD2/CD4/CD8A/IL1R2/CD3E/HLA-DMB/TNF/FLT3/EPO/IL1B/HLA-DOA/CD1D/CSF2RA 24 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 88/1171 476/8135 0.006467 0.05982 0.04595 NDUFB3/CALM3/UBE2G1/DDIT3/SLC25A5/COX7C/NDUFA1/COX6A1/VDAC1/CALM1/COX7A2/PIK3R4/FASLG/UQCRQ/PSMD7/CSNK2A2/MAP2K1/COX7B/PSMA4/BECN1/PRNP/MAPK12/HTRA2/CASP8/NDUFB6/NDUFS5/NDUFA2/PSMD13/DNAI1/COX6C/CDK5R1/PPP3CC/ITPR3/AXIN2/CSNK1A1/TOMM40/PSMA6/CSNK1E/PSMB2/NDUFS4/NDUFA6/UQCRB/GSK3B/PSMB1/NDUFA4/TUBB8/WIPI2/MAPK9/FADD/PSMB7/CSNK2B/NDUFS7/TUBA1C/TRAP1/PSMA3/PSMC4/AXIN1/ACTR1B/TNF/TNFRSF1B/NDUFV1/NDUFS8/PSEN2/COX6B1/FZD9/COX4I2/TUBA1B/PSMD8/PLCG1/WNT10A/IL1B/PLCB1/COX5A/AGER/KIF5B/BAK1/XBP1/COX5B/PSMA1/UQCRFS1/FRAT1/WNT1/VAPB/FZD6/STX1A/MAPK13/ITPR2/PSMA2 88 KEGG hsa03018 RNA degradation 20/1171 79/8135 0.007075 0.06208 0.04769 LSM3/EXOSC6/DIS3L/BTG2/PFKP/EXOSC10/HSPA9/LSM2/PABPC1/DDX6/XRN2/EDC4/BTG3/EXOSC4/DCPS/ENO1/LSM1/NUDT16/BTG1/EXOSC2 20 KEGG hsa05165 Human papillomavirus infection 64/1171 331/8135 0.007084 0.06208 0.04769 MFNG/ATP6V1D/RBL2/ATP6V0E1/HDAC1/PPP2R3C/CREB1/JAK1/ATP6V0E2/FASLG/SLC9A3R1/IKBKB/TICAM1/IRF1/MAP2K1/MAML2/SCRIB/PPP2R5A/LLGL1/TBP/CASP8/TUBG2/PPP2CB/ITGA4/IKBKG/CDK2/AXIN2/LFNG/ATP6V1E2/CSNK1A1/PPP2R1A/GSK3B/PPP2R2A/PIK3CB/CDKN1B/THBS1/FADD/EIF2AK2/PPP2R3A/PIK3R2/MX2/AXIN1/TNF/TCF7L2/RHEB/PTEN/FZD9/COL4A3/WNT10A/RB1/BAK1/VTN/IFNA2/ATP6V1B1/RBL1/COL9A2/WNT1/ATP6V1G3/ATM/ATP6V1E1/FZD6/SPP1/IFNAR1/PIK3R3 64 KEGG hsa04672 Intestinal immune network for IgA production 14/1171 49/8135 0.007501 0.06319 0.04854 HLA-DPA1/HLA-DMA/CD40LG/HLA-DRB4/CCR10/ITGA4/HLA-DPB1/TNFSF13B/CCL25/CXCL12/HLA-DMB/TNFRSF17/CCL28/HLA-DOA 14 KEGG hsa05163 Human cytomegalovirus infection 46/1171 225/8135 0.00759 0.06319 0.04854 GNB1/CALM3/CRKL/IL10RA/CREB1/JAK1/CALM1/FASLG/IKBKB/ADCY7/MAP2K1/MAPK12/CASP8/ADCY4/NFATC3/IKBKG/PPP3CC/ITPR3/RAC2/ATF2/GSK3B/PIK3CB/ROCK2/FADD/TAP1/PIK3R2/CXCL12/TAP2/TNF/RHEB/GNG11/MYC/GNG5/PTGER2/IL1B/RB1/PLCB1/CCL4/GNB4/BAK1/IFNA2/ADCY9/MAPK13/CCL5/PIK3R3/ITPR2 46 KEGG hsa05225 Hepatocellular carcinoma 36/1171 168/8135 0.008119 0.06377 0.04898 ACTG1/SMARCA4/GSTO1/BRD7/ARID1A/MAP2K1/GSTP1/PHF10/ARID2/SMARCD3/AXIN2/CSNK1A1/TGFBR1/GSK3B/LEF1/ACTL6A/PIK3CB/MGST3/PIK3R2/AXIN1/GSTO2/TCF7L2/PTEN/FZD9/PLCG1/MYC/WNT10A/RB1/GSTM4/BAK1/SMAD3/FRAT1/WNT1/FZD6/SHC1/PIK3R3 36 KEGG hsa01230 Biosynthesis of amino acids 19/1171 75/8135 0.008472 0.06377 0.04898 PYCR2/ARG1/MAT2B/CS/SHMT1/GOT1/CBS/BCAT2/GOT2/ACO1/IDH3B/PFKP/SHMT2/ACY1/ASNS/MTR/ENO1/GAPDH/PGK1 19 KEGG hsa05014 Amyotrophic lateral sclerosis 69/1171 364/8135 0.008481 0.06377 0.04898 NUP62/NUP93/NDUFB3/NUP214/ANXA7/DDIT3/COX7C/ACTG1/NDUFA1/COX6A1/VDAC1/PFN1/COX7A2/PIK3R4/UQCRQ/PSMD7/COX7B/PSMA4/BECN1/MAPK12/NUP153/NUP107/NDUFB6/NDUFS5/NDUFA2/PSMD13/DNAI1/COX6C/PPP3CC/ITPR3/TOMM40/PSMA6/PSMB2/NDUFS4/NDUFA6/UQCRB/NUP85/PSMB1/NDUFA4/TUBB8/WIPI2/UBQLN4/NXF1/RAE1/PSMB7/NDUFS7/TUBA1C/PSMA3/PSMC4/NUP160/ACTR1B/TNF/TNFRSF1B/NDUFV1/NDUFS8/COX6B1/COX4I2/TUBA1B/PSMD8/NXT1/COX5A/KIF5B/XBP1/COX5B/PSMA1/UQCRFS1/VAPB/MAPK13/PSMA2 69 KEGG hsa03022 Basal transcription factors 13/1171 45/8135 0.00889 0.06377 0.04898 GTF2B/TAF1L/TAF15/GTF2H5/TAF4/TBP/TAF2/ERCC2/TAF6L/TAF10/TAF5L/TAF1/ERCC3 13 KEGG hsa05321 Inflammatory bowel disease 17/1171 65/8135 0.00892 0.06377 0.04898 TLR5/GATA3/HLA-DPA1/HLA-DMA/IL12RB1/HLA-DRB4/HLA-DPB1/TLR2/TLR4/HLA-DMB/TNF/IL12RB2/IFNG/MAF/IL1B/HLA-DOA/SMAD3 17 KEGG hsa05416 Viral myocarditis 16/1171 60/8135 0.009061 0.06377 0.04898 ACTG1/HLA-DPA1/HLA-DMA/FYN/CASP8/CD40LG/HLA-DRB4/RAC2/PRF1/HLA-DPB1/EIF4G3/ICAM1/HLA-DMB/ITGAL/HLA-DOA/SGCA 16 KEGG hsa00410 beta-Alanine metabolism 10/1171 31/8135 0.009192 0.06377 0.04898 ALDH9A1/CNDP2/ECHS1/ALDH3A2/ALDH6A1/MLYCD/UPB1/CSAD/HIBCH/ACOX3 10 KEGG hsa05310 Asthma 10/1171 31/8135 0.009192 0.06377 0.04898 RNASE3/HLA-DPA1/HLA-DMA/CD40LG/HLA-DRB4/HLA-DPB1/MS4A2/HLA-DMB/TNF/HLA-DOA 10 KEGG hsa04722 Neurotrophin signaling pathway 27/1171 119/8135 0.009563 0.06499 0.04992 SH2B3/MAGED1/CALM3/IRAK2/CRKL/CALM1/FASLG/IKBKB/MAP2K1/MAPK12/IRAK3/PRDM4/GSK3B/MAPK9/MAPK7/PIK3CB/PIK3R2/MATK/NFKBIE/PSEN2/PLCG1/ARHGDIA/MAP3K3/MAPKAPK2/SHC1/MAPK13/PIK3R3 27 KEGG hsa05016 Huntington disease 59/1171 306/8135 0.01005 0.06695 0.05142 NDUFB3/SLC25A5/COX7C/NDUFA1/HDAC1/COX6A1/VDAC1/CREB1/SIN3A/AP2B1/COX7A2/PIK3R4/UQCRQ/PSMD7/TAF4/COX7B/PSMA4/BECN1/TBP/CASP8/NDUFB6/NDUFS5/POLR2J2/NDUFA2/PSMD13/POLR2A/DNAI1/COX6C/PSMA6/PSMB2/NDUFS4/NDUFA6/UQCRB/PSMB1/NDUFA4/TUBB8/WIPI2/MAPK9/PSMB7/NDUFS7/TUBA1C/PSMA3/PSMC4/ACTR1B/POLR2B/NDUFV1/NDUFS8/COX6B1/COX4I2/TUBA1B/PSMD8/PLCB1/COX5A/KIF5B/COX5B/PSMA1/UQCRFS1/STX1A/PSMA2 59 KEGG hsa04650 Natural killer cell mediated cytotoxicity 29/1171 131/8135 0.01052 0.06722 0.05163 LCP2/FASLG/MAP2K1/TNFSF10/FYN/CD247/SH2D1B/PPP3CC/RAC2/PRF1/NCR3/HCST/PIK3CB/PAK1/PIK3R2/ICAM1/TNF/KLRD1/PLCG1/KLRC1/IFNG/ITGAL/IFNA2/ICAM2/GZMB/SHC1/IFNAR1/PIK3R3/ULBP3 29 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 40/1171 194/8135 0.01062 0.06722 0.05163 GNB1/CALM3/ZFP36/CREB1/JAK1/CALM1/IKBKB/TICAM1/MAP2K1/BECN1/MAPK12/CASP8/NFATC3/IKBKG/PPP3CC/ITPR3/GSK3B/PREX1/LEF1/MAPK9/PIK3CB/FADD/EIF2AK2/ATG3/PIK3R2/ICAM1/TCF7L2/GNG11/PLCG1/MYC/GNG5/RB1/GNB4/BAK1/IFNA2/MAPKAPK2/MAPK13/IFNAR1/PIK3R3/ITPR2 40 KEGG hsa04152 AMPK signaling pathway 27/1171 120/8135 0.0107 0.06722 0.05163 PPP2R3C/EEF2K/EEF2/CREB1/G6PC3/PPP2R5A/PPP2CB/FASN/PFKP/FBP1/PPP2R1A/PRKAG2/PPP2R2A/RAB2A/PIK3CB/PPP2R3A/PIK3R2/PFKFB2/MLYCD/RHEB/CAMKK2/PCK1/ELAVL1/CPT1A/ACACB/PIK3R3/LIPE 27 KEGG hsa04910 Insulin signaling pathway 30/1171 137/8135 0.01095 0.06751 0.05186 HK3/CALM3/CRKL/CALM1/IKBKB/MAP2K1/G6PC3/PTPN1/FASN/HK2/FBP1/PRKAG2/GSK3B/MAPK9/PIK3CB/FLOT1/PIK3R2/PHKA2/INPP5A/PRKAR1A/RHEB/MKNK1/PYGB/PCK1/ACACB/PPP1CA/PYGM/SHC1/PIK3R3/LIPE 30 KEGG hsa01200 Carbon metabolism 26/1171 115/8135 0.01137 0.0678 0.05208 PDHB/HK3/PDHA1/MDH2/CS/SHMT1/ECHS1/GOT1/PCCA/GOT2/ACO1/IDH3B/PFKP/GPI/HK2/FBP1/SHMT2/ALDH6A1/PCCB/G6PD/HIBCH/ENO1/GAPDH/ACOX3/PGK1/ACSS1 26 KEGG hsa04620 Toll-like receptor signaling pathway 24/1171 104/8135 0.0114 0.0678 0.05208 LY96/TLR5/IKBKB/TICAM1/MAP2K1/MAPK12/CASP8/IKBKG/MAP3K8/TLR2/MAPK9/PIK3CB/FADD/TLR4/PIK3R2/TNF/IL1B/CCL4/IFNA2/MAPK13/SPP1/CCL5/IFNAR1/PIK3R3 24 KEGG hsa04514 Cell adhesion molecules 32/1171 149/8135 0.01171 0.06801 0.05224 NTNG2/HLA-DPA1/CNTNAP1/HLA-DMA/CD6/CLDN9/PTPRC/CD40LG/CTLA4/HLA-DRB4/SELE/ITGA4/VCAN/HLA-DPB1/CD2/CD4/CD58/CD8A/NLGN3/ICAM1/CADM3/HLA-DMB/MPZ/NLGN4X/ITGAL/PTPRM/NRXN1/HLA-DOA/PVR/NLGN4Y/ICAM2/SPN 32 KEGG hsa03060 Protein export 8/1171 23/8135 0.01185 0.06801 0.05224 SRP54/SPCS1/SRP68/SRPRB/OXA1L/SPCS2/SRP9/SEC61B 8 KEGG hsa01210 2-Oxocarboxylic acid metabolism 7/1171 19/8135 0.01303 0.07336 0.05635 CS/GOT1/BCAT2/GOT2/ACO1/IDH3B/ACY1 7 KEGG hsa05171 Coronavirus disease - COVID-19 46/1171 232/8135 0.01322 0.07336 0.05635 RPLP2/JAK1/RPL31/IKBKB/RPL39/RPS24/RPL26/RPS27L/RPL41/MAPK12/RPS21/RPL34/RPS27/IKBKG/RPS17/RPS15A/RPL23/TLR2/RPL38/MAPK9/RPL9/PIK3CB/RPL26L1/RPL19/EIF2AK2/RPL11/TLR4/RPL3L/PIK3R2/MX2/TNF/RPL7/RPL35A/PLCG1/RPS7/RPS29/IL1B/RPL27/RPL28/IFNA2/RPS10/RPS19/MAPK13/IFNAR1/PIK3R3/RPS4X 46 KEGG hsa04668 TNF signaling pathway 25/1171 112/8135 0.01511 0.0821 0.06307 CREB1/MMP9/IKBKB/BAG4/IRF1/MAP2K1/MAPK12/CASP8/SELE/IKBKG/ATF2/MAP3K8/MAPK9/PIK3CB/FADD/PIK3R2/ICAM1/TNF/TNFRSF1B/CEBPB/IL1B/PGAM5/MAPK13/CCL5/PIK3R3 25 KEGG hsa05340 Primary immunodeficiency 11/1171 38/8135 0.01529 0.0821 0.06307 ADA/RFX5/PTPRC/CD40LG/RFXAP/IKBKG/CD4/CD8A/TAP1/CD3E/TAP2 11 KEGG hsa04666 Fc gamma R-mediated phagocytosis 22/1171 97/8135 0.01823 0.09635 0.07401 CRKL/CFL1/MARCKSL1/MAP2K1/PTPRC/RAC2/BIN1/VASP/ARPC3/PIK3CB/WASF2/DNM2/SPHK2/PAK1/PIK3R2/PLCG1/ACTR2/ARPC5L/ARF6/MYO10/PLA2G4B/PIK3R3 22 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 17/1171 70/8135 0.01874 0.0975 0.07489 ATP6V1D/ATP6V0E1/ATP6V0E2/IKBKB/MAPK12/IKBKG/ATP6V1E2/MAPK9/CSK/PAK1/PLCG1/ATP6V1B1/ATP6V1G3/ATP6V1E1/NOD1/MAPK13/CCL5 17 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 22/1171 98/8135 0.02042 0.1038 0.0797 PRKCH/CALM3/CALM1/PRKCQ/ADCY7/MAPK12/ADCY4/ITPR3/MAPK9/PIK3CB/PIK3R2/PLCG1/TRPV2/PTGER2/IL1B/PLCB1/PPP1CA/ADCY9/PLA2G4B/MAPK13/PIK3R3/ITPR2 22 KEGG hsa04728 Dopaminergic synapse 28/1171 132/8135 0.02056 0.1038 0.0797 GNB1/CALM3/PPP2R3C/CREB1/CALM1/COMT/PPP2R5A/MAPK12/PPP2CB/PPP3CC/ITPR3/PPP2R1A/ATF2/GSK3B/PPP2R2A/MAPK9/PPP2R3A/CACNA1A/SLC18A2/MAOA/GNG11/GNG5/PLCB1/PPP1CA/GNB4/KIF5B/MAPK13/ITPR2 28 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 9/1171 30/8135 0.02154 0.1051 0.08074 MDH2/CS/SHMT1/PCCA/ACO1/SHMT2/PCCB/AFMID/ACSS1 9 KEGG hsa01523 Antifolate resistance 9/1171 30/8135 0.02154 0.1051 0.08074 ATIC/SHMT1/IKBKB/IKBKG/SHMT2/SLC19A1/TNF/GART/IL1B 9 KEGG hsa05110 Vibrio cholerae infection 13/1171 50/8135 0.02178 0.1051 0.08074 ATP6V1D/ATP6V0E1/ACTG1/ATP6V0E2/PDIA4/ARF1/ATP6V1E2/PLCG1/ATP6V1B1/ADCY9/ATP6V1G3/ATP6V1E1/SEC61B 13 KEGG hsa04218 Cellular senescence 32/1171 156/8135 0.02222 0.1057 0.08118 CALM3/RBL2/SLC25A5/ETS1/VDAC1/CALM1/MAP2K1/MAPK12/NFATC3/CDK2/PPP3CC/ITPR3/TGFBR1/E2F4/PIK3CB/RRAS/PIK3R2/RASSF5/RHEB/PTEN/MYC/MRAS/RB1/PPP1CA/RBL1/SMAD3/ATM/MAPKAPK2/MAPK13/PIK3R3/ITPR2/IGFBP3 32 KEGG hsa05152 Tuberculosis 36/1171 180/8135 0.02315 0.1074 0.08248 CD74/CAMP/CALM3/IRAK2/IL10RA/CREB1/JAK1/CALM1/HLA-DPA1/HLA-DMA/MAPK12/CASP8/RFX5/LAMP1/RFXAP/HLA-DRB4/PPP3CC/HLA-DPB1/HSPA9/TLR2/MAPK9/FADD/CLEC7A/TLR4/SPHK2/HLA-DMB/TNF/CEBPB/IFNG/IL1B/CARD9/HLA-DOA/CLEC4E/IFNA2/MAPK13/CORO1A 36 KEGG hsa00770 Pantothenate and CoA biosynthesis 7/1171 21/8135 0.02322 0.1074 0.08248 AASDHPPT/BCAT2/ALDH3A2/VNN1/ENPP3/UPB1/CSAD 7 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 43/1171 223/8135 0.02529 0.1154 0.08862 NDUFB3/SLC25A5/COX7C/NDUFA1/GSTO1/COX6A1/VDAC1/COX7A2/UQCRQ/IKBKB/MAP2K1/COX7B/PTPN1/MAPK12/NDUFB6/NDUFS5/NDUFA2/COX6C/IKBKG/NDUFS4/NDUFA6/UQCRB/NDUFA4/MAPK9/PIK3CB/MGST3/NDUFS7/PIK3R2/GSTO2/NDUFV1/NDUFS8/PTEN/COX6B1/COX4I2/GSTM4/COX5A/COX5B/UQCRFS1/CYP1B1/EPHX2/MAPK13/ACP1/PIK3R3 43 KEGG hsa03030 DNA replication 10/1171 36/8135 0.02694 0.1213 0.09314 RPA1/POLD2/POLE4/RNASEH2A/MCM4/MCM3/RPA3/RNASEH1/MCM5/POLA2 10 KEGG hsa04936 Alcoholic liver disease 29/1171 142/8135 0.03005 0.1334 0.1025 ALDH9A1/LY96/LPIN1/FASLG/IKBKB/TICAM1/IL17RA/MAPK12/ALDH3A2/CASP8/FASN/IKBKG/PRKAG2/GSK3B/LEF1/MAPK9/FADD/TLR4/MLYCD/TNF/TCF7L2/CAMKK2/ACADM/IL1B/CPT1A/ACACB/IFNA2/ACOX3/MAPK13 29 KEGG hsa03420 Nucleotide excision repair 12/1171 47/8135 0.0308 0.135 0.1037 RPA1/POLD2/XPC/POLE4/GTF2H5/RBX1/ERCC8/ERCC2/RPA3/CUL4A/ERCC5/ERCC3 12 KEGG hsa04966 Collecting duct acid secretion 8/1171 27/8135 0.03175 0.1373 0.1055 ATP6V1D/ATP6V0E1/ATP6V0E2/ATP6V1E2/CA2/ATP6V1B1/ATP6V1G3/ATP6V1E1 8 KEGG hsa04136 Autophagy - other 9/1171 32/8135 0.03241 0.1378 0.1059 PIK3R4/IGBP1/BECN1/PPP2CB/ATG10/WIPI2/ATG3/ATG9A/ATG4C 9 KEGG hsa05017 Spinocerebellar ataxia 29/1171 143/8135 0.0327 0.1378 0.1059 GTF2B/SLC25A5/VDAC1/PIK3R4/PSMD7/PSMA4/BECN1/TBP/PSMD13/ITPR3/PSMA6/PSMB2/PSMB1/WIPI2/MAPK9/PIK3CB/PSMB7/PSMA3/PSMC4/PIK3R2/CACNA1A/PSMD8/PLCB1/AFG3L2/XBP1/PSMA1/PIK3R3/ITPR2/PSMA2 29 KEGG hsa05417 Lipid and atherosclerosis 41/1171 215/8135 0.03344 0.1392 0.1069 CALM3/LY96/DDIT3/CALM1/MMP9/FASLG/NCF4/IKBKB/TICAM1/ABCA1/TNFSF10/MAPK12/CASP8/CD40LG/NFATC3/SELE/IKBKG/PPP3CC/GSK3B/TLR2/MAPK9/HSP90B1/HSP90AB1/PIK3CB/ROCK2/POU2F2/TLR4/PIK3R2/ICAM1/TNF/OLR1/HSPA6/PLCG1/IL1B/PLCB1/AGER/IFNA2/XBP1/MAPK13/CCL5/PIK3R3 41 KEGG hsa04062 Chemokine signaling pathway 37/1171 192/8135 0.03627 0.1491 0.1145 GNB1/CXCR3/CRKL/IKBKB/CX3CR1/ADCY7/MAP2K1/DOCK2/CXCR6/ADCY4/CCR10/IKBKG/RAC2/PPBP/GSK3B/PREX1/PIK3CB/ROCK2/CCL25/ITK/PAK1/PIK3R2/CXCL12/GNG11/PLCG1/GNG5/CCL28/PLCB1/CCL4/GNB4/ADCY9/CCR7/SHC1/FGR/CCL5/PIK3R3/CXCL14 37 KEGG hsa04370 VEGF signaling pathway 14/1171 59/8135 0.03739 0.1509 0.1159 SH2D2A/MAP2K1/MAPK12/PPP3CC/RAC2/PIK3CB/SPHK2/PIK3R2/PLCG1/PLA2G4B/MAPKAPK2/MAPKAPK3/MAPK13/PIK3R3 14 KEGG hsa05230 Central carbon metabolism in cancer 16/1171 70/8135 0.03761 0.1509 0.1159 PDHB/HK3/PDHA1/MAP2K1/PFKP/HK2/PIK3CB/GLS2/SLC16A3/PIK3R2/GLS/FLT3/PTEN/G6PD/MYC/PIK3R3 16 KEGG hsa04064 NF-kappa B signaling pathway 22/1171 104/8135 0.03809 0.151 0.116 PARP1/LY96/CARD11/PRKCQ/IKBKB/TICAM1/CSNK2A2/CD40LG/IKBKG/TNFSF13B/TRIM25/CSNK2B/TLR4/ICAM1/CXCL12/TNF/CYLD/PLCG1/IL1B/CCL4/ATM/TNFSF14 22 KEGG hsa05140 Leishmaniasis 17/1171 77/8135 0.04427 0.1734 0.1332 JAK1/HLA-DPA1/NCF4/MARCKSL1/HLA-DMA/MAPK12/HLA-DRB4/ITGA4/HLA-DPB1/TLR2/TLR4/HLA-DMB/TNF/IFNG/IL1B/HLA-DOA/MAPK13 17 KEGG hsa04141 Protein processing in endoplasmic reticulum 33/1171 171/8135 0.0452 0.1738 0.1335 UBE2G1/EDEM1/DDIT3/DDOST/CKAP4/PDIA4/RBX1/HERPUD1/NSFL1C/MAN1C1/MBTPS1/YOD1/PDIA6/CUL1/OS9/DNAJA1/MAPK9/UBQLN4/HSP90B1/HSP90AB1/SYVN1/EIF2AK2/SSR2/PRKCSH/NPLOC4/STT3A/HSPA6/DERL2/BAK1/XBP1/DNAJB11/DNAJC3/SEC61B 33 KEGG hsa04714 Thermogenesis 43/1171 232/8135 0.04542 0.1738 0.1335 NDUFB3/COX7C/ACTG1/NDUFA1/SMARCA4/COX6A1/CREB1/COX7A2/UQCRQ/ARID1A/ADCY7/COX7B/MAPK12/NDUFB6/NDUFS5/ADCY4/NDUFA2/SMARCD3/COX6C/PRKAG2/NDUFS4/ATF2/NDUFA6/UQCRB/CPT2/NDUFA4/ACTL6A/NDUFS7/NDUFV1/RHEB/NDUFS8/NDUFAF1/COX6B1/COX4I2/CPT1A/COX5A/ZNF516/COX5B/UQCRFS1/ADCY9/COX17/MAPK13/LIPE 43 KEGG hsa03020 RNA polymerase 9/1171 34/8135 0.0466 0.1763 0.1355 POLR3E/POLR2J2/POLR2A/POLR3H/POLR2B/POLR3B/POLR3C/CD3EAP/POLR1C 9 KEGG hsa00510 N-Glycan biosynthesis 12/1171 50/8135 0.04777 0.1781 0.1368 DDOST/ALG9/ST6GAL1/MAN1C1/DOLPP1/ALG3/ALG13/DPAGT1/ALG8/MAN2A2/STT3A/DOLK 12 KEGG hsa04621 NOD-like receptor signaling pathway 35/1171 184/8135 0.04812 0.1781 0.1368 CAMP/TXN/VDAC1/JAK1/IKBKB/TICAM1/MAPK12/AIM2/CASP8/NEK7/IKBKG/NLRP12/ITPR3/DEFA4/MAPK9/GBP4/HSP90AB1/FADD/TLR4/TNF/TXN2/DEFA5/TRPV2/IL1B/PLCB1/CARD9/IFNA2/CASP5/TXNIP/NOD1/MAPK13/CCL5/IFNAR1/ITPR2/TP53BP1 35 KEGG hsa00010 Glycolysis / Gluconeogenesis 15/1171 67/8135 0.05079 0.1859 0.1428 PDHB/ALDH9A1/HK3/PDHA1/G6PC3/ALDH3A2/PFKP/GPI/HK2/FBP1/PCK1/ENO1/GAPDH/PGK1/ACSS1 15 KEGG hsa04071 Sphingolipid signaling pathway 24/1171 119/8135 0.05148 0.1863 0.1431 PPP2R3C/MAP2K1/PPP2R5A/MAPK12/FYN/PPP2CB/RAC2/PPP2R1A/PPP2R2A/MAPK9/PIK3CB/ROCK2/MS4A2/PPP2R3A/SPHK2/PIK3R2/SMPD2/TNF/PTEN/NSMAF/PLCB1/SGPP1/MAPK13/PIK3R3 24 KEGG hsa05131 Shigellosis 45/1171 247/8135 0.05305 0.19 0.1459 FNBP1/RRAGD/HK3/CRKL/TLR5/ACTG1/VDAC1/PFN1/PRKCQ/PIK3R4/IKBKB/ARF1/RBX1/BECN1/MAPK12/IKBKG/HK2/ITPR3/CBX3/GSK3B/CUL1/ARPC3/WIPI2/MAPK9/PIK3CB/ROCK2/WASF2/TLR4/PIK3R2/TNF/ELMO2/PLCG1/ACTR2/CAPNS1/IL1B/PLCB1/ARPC5L/ARF6/ATM/MYL7/NOD1/MAPK13/CCL5/PIK3R3/ITPR2 45 KEGG hsa00270 Cysteine and methionine metabolism 12/1171 51/8135 0.05461 0.1935 0.1486 DNMT1/MAT2B/MDH2/GOT1/CBS/BCAT2/GOT2/SRM/ENOPH1/MPST/MTR/GCLM 12 KEGG hsa00670 One carbon pool by folate 6/1171 20/8135 0.05665 0.1968 0.1511 ATIC/SHMT1/MTHFS/SHMT2/GART/MTR 6 KEGG hsa00020 Citrate cycle (TCA cycle) 8/1171 30/8135 0.05673 0.1968 0.1511 PDHB/PDHA1/MDH2/CS/ACLY/ACO1/IDH3B/PCK1 8 KEGG hsa04066 HIF-1 signaling pathway 22/1171 109/8135 0.05988 0.2029 0.1559 PDHB/HK3/PDHA1/MAP2K1/RBX1/PFKP/HK2/PIK3CB/CDKN1B/TLR4/PIK3R2/MKNK1/CUL2/PLCG1/IFNG/EPO/ANGPT1/TF/ENO1/GAPDH/PGK1/PIK3R3 22 KEGG hsa05160 Hepatitis C 30/1171 157/8135 0.06048 0.2029 0.1559 CD81/JAK1/FASLG/IKBKB/TICAM1/MAP2K1/CLDN9/CASP8/PPP2CB/IKBKG/CDK2/SCARB1/PPP2R1A/GSK3B/PPP2R2A/PIK3CB/FADD/EIF2AK2/PIK3R2/MX2/TNF/YWHAQ/MYC/IFNG/RB1/BAK1/IFNA2/YWHAH/IFNAR1/PIK3R3 30 KEGG hsa00983 Drug metabolism - other enzymes 17/1171 80/8135 0.06061 0.2029 0.1559 GSTO1/RRM1/GSTP1/UCKL1/CES2/MGST3/UCK1/IMPDH2/MPO/GSTO2/UPB1/HPRT1/GUSB/GSTM4/UGT2B28/UGT1A5/RRM2 17 KEGG hsa05162 Measles 27/1171 139/8135 0.06094 0.2029 0.1559 IL2RB/RAB9A/JAK1/FASLG/IKBKB/CSNK2A2/CASP8/IKBKG/CDK2/GSK3B/TLR2/MAPK9/PIK3CB/CDKN1B/FADD/CSNK2B/EIF2AK2/TLR4/CD3E/PIK3R2/MX2/HSPA6/IL1B/BAK1/IFNA2/IFNAR1/PIK3R3 27 KEGG hsa05210 Colorectal cancer 18/1171 86/8135 0.06199 0.2044 0.157 MLH1/RALGDS/MAP2K1/AXIN2/RAC2/TGFBR1/GSK3B/LEF1/MAPK9/PIK3CB/PIK3R2/AXIN1/TCF7L2/MYC/BAK1/SMAD3/PIK3R3/DCC 18 KEGG hsa05213 Endometrial cancer 13/1171 58/8135 0.06548 0.2125 0.1632 MLH1/MAP2K1/AXIN2/GSK3B/LEF1/PIK3CB/PIK3R2/AXIN1/TCF7L2/PTEN/MYC/BAK1/PIK3R3 13 KEGG hsa04380 Osteoclast differentiation 25/1171 128/8135 0.06573 0.2125 0.1632 LCP2/CREB1/JAK1/NCF4/IKBKB/MAP2K1/LILRA5/MAPK12/FYN/CSF1R/IKBKG/PPP3CC/TGFBR1/MAPK9/PIK3CB/PIK3R2/TNF/TNFRSF11B/SIRPG/CYLD/IFNG/IL1B/MAPK13/IFNAR1/PIK3R3 25 KEGG hsa05320 Autoimmune thyroid disease 12/1171 53/8135 0.07022 0.2235 0.1717 HLA-DPA1/FASLG/HLA-DMA/CD40LG/CTLA4/HLA-DRB4/PRF1/HLA-DPB1/HLA-DMB/HLA-DOA/IFNA2/GZMB 12 KEGG hsa04140 Autophagy - animal 27/1171 141/8135 0.07048 0.2235 0.1717 RRAGD/UVRAG/PRKCQ/PIK3R4/IGBP1/MAP2K1/BECN1/LAMP1/PPP2CB/ATG10/WIPI2/MAPK9/PIK3CB/ATG3/RRAS/ATG9A/PIK3R2/SH3GLB1/RHEB/CAMKK2/PTEN/ATG4C/MRAS/DAPK2/ATG16L2/MTMR3/PIK3R3 27 KEGG hsa05220 Chronic myeloid leukemia 16/1171 76/8135 0.07219 0.2268 0.1742 CRKL/HDAC1/IKBKB/MAP2K1/IKBKG/CTBP1/TGFBR1/PIK3CB/CDKN1B/PIK3R2/MYC/RB1/BAK1/SMAD3/SHC1/PIK3R3 16 KEGG hsa04330 Notch signaling pathway 13/1171 59/8135 0.07342 0.2282 0.1753 MFNG/HDAC1/MAML2/CTBP1/LFNG/DTX2/NCSTN/DTX3/PSEN2/DTX4/DLL1/APH1B/PSENEN 13 KEGG hsa05130 Pathogenic Escherichia coli infection 36/1171 197/8135 0.07429 0.2282 0.1753 TLR5/ACTG1/FASLG/SLC9A3R1/IKBKB/ARF1/TNFSF10/CLDN9/MAPK12/FYN/CASP8/IKBKG/ARPC3/TUBB8/MAPK9/WIPF2/ROCK2/WASF2/FADD/TUBA1C/TLR4/PAK1/MYO1F/TNF/TUBA1B/NCK1/ACTR2/IL1B/BAK1/NLRP4/ARPC5L/ARF6/GAPDH/MYO10/F2R/MAPK13 36 KEGG hsa01250 Biosynthesis of nucleotide sugars 9/1171 37/8135 0.07471 0.2282 0.1753 GNE/GMDS/HK3/GPI/HK2/PMM2/NANS/TGDS/CMAS 9 KEGG hsa04922 Glucagon signaling pathway 21/1171 107/8135 0.08268 0.2503 0.1923 PDHB/CALM3/PDHA1/CREB1/CALM1/G6PC3/PFKP/PPP3CC/ITPR3/FBP1/PRKAG2/ATF2/PHKA2/PRMT1/PYGB/PCK1/CPT1A/ACACB/PLCB1/PYGM/ITPR2 21 KEGG hsa00220 Arginine biosynthesis 6/1171 22/8135 0.08506 0.2529 0.1943 ARG1/GOT1/GOT2/GLS2/ACY1/GLS 6 KEGG hsa00340 Histidine metabolism 6/1171 22/8135 0.08506 0.2529 0.1943 ALDH9A1/CNDP2/HNMT/ALDH3A2/HDC/MAOA 6 KEGG hsa04142 Lysosome 25/1171 132/8135 0.08794 0.2584 0.1985 AP4B1/AP3D1/FUCA1/CTSC/CTSW/AP1M1/LIPA/LAMP1/NPC1/NPC2/SLC17A5/NAGPA/AP1B1/LGMN/CLN3/CTSG/DMXL2/LITAF/AP3B2/SLC11A1/AP4E1/GUSB/GBA/ARSA/DNASE2 25 KEGG hsa04110 Cell cycle 24/1171 126/8135 0.08846 0.2584 0.1985 RBL2/CDKN1C/HDAC1/RBX1/ANAPC5/ANAPC1/CDK2/GSK3B/CUL1/E2F4/CDKN1B/MCM4/MCM3/CDC23/YWHAQ/MYC/PRKDC/RB1/CDC14A/RBL1/SMAD3/ATM/MCM5/YWHAH 24 KEGG hsa04931 Insulin resistance 21/1171 108/8135 0.08938 0.2588 0.1988 CREB1/PRKCQ/IKBKB/G6PC3/PTPN1/SLC27A3/PRKAG2/GSK3B/MAPK9/PIK3CB/PIK3R2/MLXIP/TNF/PTEN/PYGB/PCK1/CPT1A/ACACB/PPP1CA/PYGM/PIK3R3 21 KEGG hsa00051 Fructose and mannose metabolism 8/1171 33/8135 0.09152 0.2605 0.2001 GMDS/HK3/PFKP/HK2/FBP1/PMM2/AKR1B1/PFKFB2 8 KEGG hsa04130 SNARE interactions in vesicular transport 8/1171 33/8135 0.09152 0.2605 0.2001 STX6/BET1L/SNAP23/VAMP3/STX2/SEC22B/VAMP5/STX1A 8 KEGG hsa05221 Acute myeloid leukemia 14/1171 67/8135 0.09308 0.2614 0.2008 IKBKB/MAP2K1/CSF1R/DUSP6/IKBKG/LEF1/PIK3CB/PIK3R2/MPO/CEBPA/TCF7L2/FLT3/MYC/PIK3R3 14 KEGG hsa04371 Apelin signaling pathway 26/1171 139/8135 0.0934 0.2614 0.2008 KLF2/GNB1/CALM3/CALM1/PIK3R4/ADCY7/MAP2K1/BECN1/ADCY4/ITPR3/PRKAG2/TGFBR1/EGR1/MEF2D/SPHK2/RRAS/GNG11/GNG5/MRAS/PLCB1/GNB4/SMAD3/ADCY9/SPP1/ITPR2/LIPE 26 KEGG hsa05144 Malaria 11/1171 50/8135 0.0955 0.265 0.2036 CD81/CD40LG/SELE/TLR2/THBS1/TLR4/ICAM1/TNF/IFNG/ITGAL/IL1B 11 KEGG hsa05215 Prostate cancer 19/1171 97/8135 0.09674 0.2662 0.2045 CREB1/MMP9/IKBKB/MAP2K1/GSTP1/IKBKG/CDK2/GSK3B/LEF1/HSP90B1/HSP90AB1/PIK3CB/CDKN1B/IL1R2/PIK3R2/TCF7L2/PTEN/RB1/PIK3R3 19 KEGG hsa04664 Fc epsilon RI signaling pathway 14/1171 68/8135 0.1025 0.2797 0.2149 LCP2/MAP2K1/MAPK12/FYN/RAC2/MAPK9/PIK3CB/MS4A2/PIK3R2/TNF/PLCG1/PLA2G4B/MAPK13/PIK3R3 14 KEGG hsa04623 Cytosolic DNA-sensing pathway 13/1171 63/8135 0.1112 0.3001 0.2305 IKBKB/POLR3E/AIM2/IKBKG/POLR3H/POLR3B/IL1B/CCL4/POLR3C/IFNA2/ZBP1/CCL5/POLR1C 13 KEGG hsa04723 Retrograde endocannabinoid signaling 27/1171 148/8135 0.1118 0.3001 0.2305 GNB1/NDUFB3/NDUFA1/DAGLA/ADCY7/MAPK12/NDUFB6/NDUFS5/ADCY4/NDUFA2/ITPR3/NDUFS4/NDUFA6/NDUFA4/MAPK9/NDUFS7/DAGLB/CACNA1A/NDUFV1/NDUFS8/GNG11/GNG5/PLCB1/GNB4/ADCY9/MAPK13/ITPR2 27 KEGG hsa04912 GnRH signaling pathway 18/1171 93/8135 0.1133 0.3001 0.2305 CALM3/CALM1/ADCY7/MAP2K1/MAPK12/ADCY4/ITPR3/MAPK9/MAPK7/EGR1/MAP3K2/PLCB1/MAP3K3/ADCY9/PLA2G4B/MAP3K4/MAPK13/ITPR2 18 KEGG hsa04260 Cardiac muscle contraction 17/1171 87/8135 0.1136 0.3001 0.2305 COX7C/COX6A1/COX7A2/UQCRQ/COX7B/COX6C/UQCRB/CACNG6/CACNA2D2/TPM3/TPM4/COX6B1/COX4I2/CACNG4/COX5A/COX5B/UQCRFS1 17 KEGG hsa04930 Type II diabetes mellitus 10/1171 46/8135 0.1157 0.3033 0.233 HK3/IKBKB/HK2/MAPK9/PIK3CB/PIK3R2/PDX1/CACNA1A/TNF/PIK3R3 10 KEGG hsa05145 Toxoplasmosis 21/1171 112/8135 0.1196 0.3072 0.236 LY96/IL10RA/JAK1/HLA-DPA1/IKBKB/HLA-DMA/MAPK12/CASP8/CD40LG/HLA-DRB4/IKBKG/HLA-DPB1/TLR2/MAPK9/TLR4/HLA-DMB/TNF/HSPA6/IFNG/HLA-DOA/MAPK13 21 KEGG hsa00480 Glutathione metabolism 12/1171 58/8135 0.1208 0.3072 0.236 GSTO1/RRM1/GSTP1/SRM/OPLAH/MGST3/PRDX6/GSTO2/G6PD/GSTM4/GCLM/RRM2 12 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 19/1171 100/8135 0.1216 0.3072 0.236 IL2RB/CXCR3/IL10RA/CX3CR1/TNFSF10/CSF1R/TNFRSF14/CCR10/PPBP/CCL25/CXCL12/TNF/TNFRSF1B/CCL28/CCL4/TNFSF14/CCR7/CCL5/CXCL14 19 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 19/1171 100/8135 0.1216 0.3072 0.236 MAPK12/SELE/TGFBR1/THBD/MAPK9/EGR1/PIK3CB/CDKN1B/PIK3R2/ICAM1/TNF/PLCG1/COL4A3/IL1B/PLCB1/AGER/SMAD3/MAPK13/PIK3R3 19 KEGG hsa05161 Hepatitis B 29/1171 162/8135 0.1223 0.3072 0.236 CREB1/JAK1/MMP9/FASLG/IKBKB/TICAM1/MAP2K1/MAPK12/CASP8/NFATC3/IKBKG/CDK2/ATF2/TGFBR1/TLR2/MAPK9/PIK3CB/FADD/TLR4/PIK3R2/TNF/YWHAQ/MYC/RB1/IFNA2/SMAD3/MAPK13/IFNAR1/PIK3R3 29 KEGG hsa05212 Pancreatic cancer 15/1171 76/8135 0.1232 0.3072 0.236 JAK1/RALGDS/IKBKB/MAP2K1/IKBKG/RAC2/TGFBR1/MAPK9/PIK3CB/PIK3R2/RB1/BAK1/SMAD3/ARHGEF6/PIK3R3 15 KEGG hsa04114 Oocyte meiosis 24/1171 131/8135 0.1236 0.3072 0.236 CALM3/CPEB3/CALM1/ADCY7/MAP2K1/RBX1/PPP2R5A/ANAPC5/MAPK12/ANAPC1/ADCY4/PPP2CB/CDK2/PPP3CC/ITPR3/PPP2R1A/CUL1/CDC23/YWHAQ/PPP1CA/ADCY9/YWHAH/MAPK13/ITPR2 24 KEGG hsa04520 Adherens junction 14/1171 71/8135 0.134 0.3305 0.2538 ACTG1/CSNK2A2/PTPN1/FYN/RAC2/TGFBR1/LEF1/WASF2/CSNK2B/TCF7L2/PTPRM/SMAD3/FER/ACP1 14 KEGG hsa04670 Leukocyte transendothelial migration 21/1171 114/8135 0.1368 0.335 0.2573 ACTG1/MMP9/NCF4/CLDN9/MAPK12/ITGA4/RAC2/VASP/PIK3CB/ROCK2/ITK/TXK/PIK3R2/ICAM1/CXCL12/RASSF5/PLCG1/ITGAL/MYL7/MAPK13/PIK3R3 21 KEGG hsa00380 Tryptophan metabolism 9/1171 42/8135 0.1405 0.3415 0.2623 ALDH9A1/HADH/ECHS1/ALDH3A2/KYNU/AFMID/MAOA/CYP1B1/GCDH 9 KEGG hsa04217 Necroptosis 28/1171 159/8135 0.1467 0.3539 0.2718 PARP1/SLC25A5/VDAC1/JAK1/FASLG/TICAM1/TNFSF10/CASP8/FAF1/CHMP5/CHMP1B/MAPK9/HSP90AB1/FADD/EIF2AK2/TLR4/TNF/CYLD/PYGB/IFNG/IL1B/PGAM5/ALOX15/PYGM/IFNA2/PLA2G4B/ZBP1/IFNAR1 28 KEGG hsa04710 Circadian rhythm 7/1171 31/8135 0.148 0.3545 0.2723 CRY1/CREB1/RBX1/CRY2/CSNK1E/PRKAG2/CUL1 7 KEGG hsa00071 Fatty acid degradation 9/1171 43/8135 0.1564 0.3683 0.2829 ALDH9A1/HADH/ECHS1/ALDH3A2/CPT2/ACADM/CPT1A/ACOX3/GCDH 9 KEGG hsa04921 Oxytocin signaling pathway 27/1171 154/8135 0.1575 0.3683 0.2829 MYL6B/MYL6/CALM3/ACTG1/EEF2K/EEF2/CALM1/ADCY7/MAP2K1/ADCY4/NFATC3/PPP3CC/PPP1R12C/ITPR3/PRKAG2/CACNG6/MAPK7/PPP1R12B/CACNA2D2/ROCK2/CAMKK2/CACNG4/PLCB1/PPP1CA/ADCY9/PLA2G4B/ITPR2 27 KEGG hsa01524 Platinum drug resistance 14/1171 73/8135 0.1576 0.3683 0.2829 GSTO1/MLH1/FASLG/GSTP1/CASP8/PIK3CB/MGST3/FADD/PIK3R2/GSTO2/GSTM4/BAK1/ATM/PIK3R3 14 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 10/1171 49/8135 0.1581 0.3683 0.2829 GNE/GMDS/HK3/GNPDA1/GPI/HK2/PMM2/NANS/CHIT1/CMAS 10 KEGG hsa04072 Phospholipase D signaling pathway 26/1171 148/8135 0.1603 0.3692 0.2836 RALGDS/ADCY7/MAP2K1/ARF1/FYN/GRM3/ADCY4/GRM8/AGPAT2/PIK3CB/MS4A2/DNM2/SPHK2/RRAS/PIK3R2/RHEB/PLCG1/MRAS/PLCB1/DGKI/ARF6/ADCY9/PLA2G4B/F2R/SHC1/PIK3R3 26 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 6/1171 26/8135 0.1608 0.3692 0.2836 PIGT/PIGU/PIGM/PIGN/PIGQ/PIGP 6 KEGG hsa04120 Ubiquitin mediated proteolysis 25/1171 142/8135 0.1632 0.3723 0.286 HERC1/UBE2G1/PIAS3/RBX1/UBE2E2/UBE2Q1/ANAPC5/ANAPC1/ERCC8/SAE1/PRPF19/CUL1/COP1/SYVN1/CUL3/HERC3/CUL4A/TRIM32/CDC23/CUL7/CUL2/TRIM37/RNF7/SMURF2/HERC2 25 KEGG hsa04979 Cholesterol metabolism 10/1171 50/8135 0.1738 0.3937 0.3024 VDAC1/ABCA1/LIPA/NPC1/NPC2/SCARB1/STARD3/ABCG5/OSBPL5/VAPB 10 KEGG hsa04068 FoxO signaling pathway 23/1171 131/8135 0.1789 0.4025 0.3092 KLF2/RBL2/FASLG/IKBKB/MAP2K1/G6PC3/TNFSF10/MAPK12/CDK2/CSNK1E/PRKAG2/TGFBR1/MAPK9/PIK3CB/CDKN1B/PIK3R2/PRMT1/PTEN/PCK1/SMAD3/ATM/MAPK13/PIK3R3 23 KEGG hsa04920 Adipocytokine signaling pathway 13/1171 69/8135 0.1856 0.4112 0.3158 PRKCQ/IKBKB/G6PC3/IKBKG/PRKAG2/MAPK9/TNF/TNFRSF1B/NFKBIE/CAMKK2/PCK1/CPT1A/ACACB 13 KEGG hsa04935 Growth hormone synthesis, secretion and action 21/1171 119/8135 0.1857 0.4112 0.3158 CRKL/CREB1/ADCY7/GHR/MAP2K1/MAPK12/ADCY4/ITPR3/ATF2/GSK3B/MAPK9/PIK3CB/PIK3R2/PLCG1/PLCB1/ADCY9/SHC1/MAPK13/PIK3R3/ITPR2/IGFBP3 21 KEGG hsa04350 TGF-beta signaling pathway 17/1171 94/8135 0.1877 0.4112 0.3158 SMAD7/TGIF2/RBX1/PPP2CB/PPP2R1A/TGFBR1/CUL1/E2F4/THBS1/TNF/DCN/MYC/IFNG/ID3/RBL1/SMURF2/SMAD3 17 KEGG hsa05134 Legionellosis 11/1171 57/8135 0.1891 0.4112 0.3158 TLR5/ARF1/CASP8/TLR2/SEC22B/BCL2L13/TLR4/CLK4/TNF/HSPA6/IL1B 11 KEGG hsa04010 MAPK signaling pathway 48/1171 294/8135 0.1891 0.4112 0.3158 SRF/DDIT3/CRKL/FASLG/DUSP5/MAP4K1/IKBKB/MAP2K1/MAPK12/CSF1R/DUSP6/DUSP10/NFATC3/IKBKG/PPP3CC/RAC2/ATF2/TGFBR1/MAP3K8/MAPK9/CACNG6/MAPK7/CACNA2D2/PPM1A/FLNB/MAP4K2/RRAS/PAK1/MAPKAPK5/CACNA1A/TNF/FLT3/HSPA6/MKNK1/CACNG4/MYC/MAP3K2/MRAS/IL1B/DUSP2/EPHA2/MAP3K3/ANGPT1/PLA2G4B/MAPKAPK2/MAP3K4/MAPKAPK3/MAPK13 48 KEGG hsa00330 Arginine and proline metabolism 10/1171 51/8135 0.1902 0.4112 0.3158 PYCR2/ALDH9A1/ARG1/CNDP2/GOT1/CKB/ALDH3A2/GOT2/SRM/MAOA 10 KEGG hsa04146 Peroxisome 15/1171 82/8135 0.1939 0.414 0.318 ECH1/HMGCL/MPV17/AMACR/PEX14/PEX5/PECR/PXMP4/AGPS/PEX10/MLYCD/PHYH/ACOX2/ACOX3/EPHX2 15 KEGG hsa04662 B cell receptor signaling pathway 15/1171 82/8135 0.1939 0.414 0.318 CARD11/CD81/CR2/IKBKB/MAP2K1/LILRA5/NFATC3/IKBKG/PPP3CC/RAC2/GSK3B/PIK3CB/PIK3R2/NFKBIE/PIK3R3 15 KEGG hsa05133 Pertussis 14/1171 76/8135 0.1969 0.4177 0.3209 CALM3/LY96/CALM1/CFL1/TICAM1/IRF1/MAPK12/MAPK9/TLR4/TNF/IRF8/IL1B/NOD1/MAPK13 14 KEGG hsa00240 Pyrimidine metabolism 11/1171 58/8135 0.205 0.4322 0.332 DCTD/DCK/RRM1/UCKL1/ENTPD1/UCK1/ENPP3/UPB1/NT5C1B/NUDT2/RRM2 11 KEGG hsa05100 Bacterial invasion of epithelial cells 14/1171 77/8135 0.211 0.4418 0.3394 CRKL/ACTG1/ARPC3/PIK3CB/WASF2/DNM2/PIK3R2/ELMO3/ELMO2/ACTR2/ARHGAP10/ARPC5L/SHC1/PIK3R3 14 KEGG hsa00230 Purine metabolism 22/1171 128/8135 0.2142 0.4457 0.3424 ATIC/ADA/DCK/ADCY7/RRM1/PDE4B/ADCY4/NUDT9/PFAS/ENTPD1/DGUOK/ENPP3/IMPDH2/AK1/GART/HPRT1/NUDT16/ADCY9/NT5C1B/ALLC/NUDT2/RRM2 22 KEGG hsa03008 Ribosome biogenesis in eukaryotes 19/1171 109/8135 0.2162 0.4467 0.3431 IMP3/CSNK2A2/NAT10/DKC1/REXO1/IMP4/RAN/NXF1/NOB1/CSNK2B/XRN2/NOL6/MPHOSPH10/NVL/RBM28/HEATR1/NXT1/GTPBP4/WDR75 19 KEGG hsa04310 Wnt signaling pathway 28/1171 167/8135 0.2173 0.4467 0.3431 CSNK2A2/RBX1/RUVBL1/NFATC3/PPP3CC/AXIN2/CTBP1/RAC2/CSNK1A1/CSNK1E/GSK3B/DAAM2/CUL1/LEF1/MAPK9/ROCK2/CSNK2B/AXIN1/TCF7L2/FZD9/MYC/WNT10A/RYK/PLCB1/SMAD3/FRAT1/WNT1/FZD6 28 KEGG hsa00910 Nitrogen metabolism 4/1171 17/8135 0.2211 0.4516 0.3469 CA4/CA2/CA1/CA12 4 KEGG hsa04934 Cushing syndrome 26/1171 155/8135 0.227 0.4555 0.3499 CREB1/ADCY7/MAP2K1/ADCY4/CDK2/ITPR3/SCARB1/AXIN2/ATF2/GSK3B/LEF1/ASH2L/CDKN1B/RASD1/AXIN1/TCF7L2/NR5A1/FZD9/WNT10A/RB1/PLCB1/ADCY9/WNT1/FZD6/ITPR2/CRH 26 KEGG hsa00620 Pyruvate metabolism 9/1171 47/8135 0.2276 0.4555 0.3499 PDHB/ALDH9A1/PDHA1/MDH2/ALDH3A2/ACYP1/PCK1/ACACB/ACSS1 9 KEGG hsa04973 Carbohydrate digestion and absorption 9/1171 47/8135 0.2276 0.4555 0.3499 HK3/G6PC3/SLC37A4/HK2/SLC2A5/PIK3CB/PIK3R2/PLCB1/PIK3R3 9 KEGG hsa04964 Proximal tubule bicarbonate reclamation 5/1171 23/8135 0.2286 0.4555 0.3499 CA4/CA2/GLS2/GLS/PCK1 5 KEGG hsa04137 Mitophagy - animal 13/1171 72/8135 0.2298 0.4555 0.3499 CSNK2A2/BECN1/MAPK9/BCL2L13/CSNK2B/RRAS/ATG9A/FIS1/TAX1BP1/MRAS/PGAM5/TOMM7/USP15 13 KEGG hsa05226 Gastric cancer 25/1171 149/8135 0.2321 0.4573 0.3513 MLH1/MAP2K1/ABCB1/CDK2/AXIN2/CSNK1A1/TGFBR1/GSK3B/LEF1/PIK3CB/CDKN1B/PIK3R2/AXIN1/TCF7L2/FZD9/MYC/WNT10A/RB1/BAK1/SMAD3/FRAT1/WNT1/FZD6/SHC1/PIK3R3 25 KEGG hsa01232 Nucleotide metabolism 15/1171 85/8135 0.2352 0.4607 0.3539 DCTD/ADA/DCK/RRM1/UCKL1/ENTPD1/DGUOK/UCK1/ENPP3/IMPDH2/AK1/HPRT1/NUDT16/NT5C1B/RRM2 15 KEGG hsa00511 Other glycan degradation 4/1171 18/8135 0.2542 0.4922 0.3781 FUCA1/GBA/NEU2/MAN2B2 4 KEGG hsa00500 Starch and sucrose metabolism 7/1171 36/8135 0.2542 0.4922 0.3781 HK3/G6PC3/GPI/HK2/ENPP3/PYGB/PYGM 7 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/1171 24/8135 0.2571 0.4949 0.3802 XYLT2/EXTL3/NDST1/EXT1/B4GALT7 5 KEGG hsa05143 African trypanosomiasis 7/1171 37/8135 0.2778 0.5287 0.4061 FASLG/SELE/ICAM1/TNF/IFNG/IL1B/PLCB1 7 KEGG hsa05216 Thyroid cancer 7/1171 37/8135 0.2778 0.5287 0.4061 TFG/MAP2K1/LEF1/TPM3/TCF7L2/MYC/BAK1 7 KEGG hsa04060 Cytokine-cytokine receptor interaction 46/1171 295/8135 0.2993 0.5662 0.4349 IL2RB/CXCR3/IL10RA/FASLG/CX3CR1/IL27RA/GHR/TNFRSF21/IL17RA/CXCR6/TNFSF10/CSF1R/TNFSF12/IL12RB1/CD40LG/TNFRSF14/CCR10/PPBP/TGFBR1/CD4/TNFRSF25/TNFSF13B/TNFRSF12A/CLCF1/IL1R2/CCL25/CXCL12/TNF/TNFRSF1B/IL32/TNFRSF11B/TNFRSF17/IL12RB2/IL25/IFNG/CCL28/EPO/IL1B/CCL4/IFNA2/TNFSF14/CCR7/CCL5/IFNAR1/CSF2RA/CXCL14 46 KEGG hsa04926 Relaxin signaling pathway 21/1171 129/8135 0.305 0.5708 0.4384 GNB1/CREB1/MMP9/ADCY7/MAP2K1/MAPK12/ADCY4/ATF2/TGFBR1/MAPK9/PIK3CB/PIK3R2/GNG11/GNG5/COL4A3/PLCB1/GNB4/ADCY9/SHC1/MAPK13/PIK3R3 21 KEGG hsa04360 Axon guidance 29/1171 182/8135 0.3051 0.5708 0.4384 NTNG2/CFL1/ABLIM1/FYN/SSH1/NFATC3/PPP3CC/RAC2/GSK3B/PAK4/PIK3CB/ROCK2/RRAS/PAK1/PIK3R2/CXCL12/EFNB1/DPYSL2/PLCG1/NCK1/SEMA3C/RYK/EPHA2/EPHA4/PLXNA1/LRIG2/PIK3R3/DCC/EPHA7 29 KEGG hsa04215 Apoptosis - multiple species 6/1171 32/8135 0.3093 0.5753 0.4419 BECN1/HTRA2/CASP8/MAPK9/FADD/BAK1 6 KEGG hsa04070 Phosphatidylinositol signaling system 16/1171 97/8135 0.3177 0.5872 0.451 CALM3/CALM1/MTM1/ITPR3/PIK3CB/PIK3R2/INPP5A/INPP1/PTEN/IPPK/PLCG1/PLCB1/DGKI/MTMR3/PIK3R3/ITPR2 16 KEGG hsa04015 Rap1 signaling pathway 33/1171 210/8135 0.3192 0.5872 0.451 CALM3/LCP2/CRKL/ACTG1/EVL/PFN1/CALM1/RALGDS/ADCY7/MAP2K1/MAPK12/CSF1R/ADCY4/RAC2/VASP/RGS14/PIK3CB/THBS1/RRAS/PIK3R2/RASSF5/PLCG1/MRAS/SKAP1/ITGAL/PLCB1/EPHA2/RAPGEF6/ANGPT1/ADCY9/F2R/MAPK13/PIK3R3 33 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 4/1171 20/8135 0.3229 0.5908 0.4539 XYLT2/CHST12/B4GALT7/CHST7 4 KEGG hsa00513 Various types of N-glycan biosynthesis 7/1171 39/8135 0.3264 0.5909 0.4539 DDOST/ALG9/MAN1C1/ALG3/ALG13/MAN2A2/STT3A 7 KEGG hsa04611 Platelet activation 20/1171 124/8135 0.3265 0.5909 0.4539 LCP2/ACTG1/SNAP23/ADCY7/MAPK12/FYN/ADCY4/ITPR3/VASP/PIK3CB/ROCK2/PIK3R2/PLCB1/PPP1CA/ADCY9/PLA2G4B/F2R/MAPK13/PIK3R3/ITPR2 20 KEGG hsa04721 Synaptic vesicle cycle 13/1171 78/8135 0.3288 0.5918 0.4546 ATP6V1D/ATP6V0E1/AP2B1/ATP6V0E2/STX2/ATP6V1E2/DNM2/CACNA1A/SLC18A2/ATP6V1B1/ATP6V1G3/ATP6V1E1/STX1A 13 KEGG hsa04012 ErbB signaling pathway 14/1171 85/8135 0.3361 0.5973 0.4588 CRKL/MAP2K1/GSK3B/MAPK9/PAK4/PIK3CB/CDKN1B/PAK1/PIK3R2/PLCG1/NCK1/MYC/SHC1/PIK3R3 14 KEGG hsa03410 Base excision repair 6/1171 33/8135 0.3363 0.5973 0.4588 PARP1/APEX2/POLD2/POLE4/MUTYH/PARP2 6 KEGG hsa05205 Proteoglycans in cancer 32/1171 205/8135 0.3372 0.5973 0.4588 ACTG1/MMP9/FASLG/MAP2K1/MAPK12/PPP1R12C/ITPR3/DDX5/TLR2/PPP1R12B/PIK3CB/ROCK2/THBS1/FLNB/TLR4/RRAS/PAK1/PIK3R2/TNF/FZD9/DCN/PLCG1/MYC/MRAS/WNT10A/PPP1CA/VTN/WNT1/FZD6/MAPK13/PIK3R3/ITPR2 32 KEGG hsa05202 Transcriptional misregulation in cancer 30/1171 193/8135 0.3531 0.6221 0.4779 IL2RB/DDIT3/HDAC1/SIN3A/MMP9/SLC45A3/EWSR1/TAF15/BCL11B/CSF1R/DUSP6/DEFA4/DDX5/CDKN1B/IL1R2/PROM1/MPO/CEBPA/PBX3/TCF3/CEBPB/DEFA5/FLT3/NFKBIZ/MYC/MAF/BAK1/ATM/GZMB/IGFBP3 30 KEGG hsa01240 Biosynthesis of cofactors 24/1171 153/8135 0.357 0.6257 0.4806 MAT2B/SHMT1/PDXP/BCAT2/ALDH3A2/PNPO/GCH1/COQ7/DHRS3/SHMT2/PMM2/AK1/EARS2/KYNU/AFMID/GUSB/UROS/RFK/GCLM/NADSYN1/UGT2B28/UGT1A5/NMNAT3/FLAD1 24 KEGG hsa04270 Vascular smooth muscle contraction 21/1171 134/8135 0.3721 0.6487 0.4983 MYL6B/MYL6/PRKCH/CALM3/CALM1/PRKCQ/ADCY7/MAP2K1/ADCY4/PPP1R12C/ITPR3/CALCA/PPP1R12B/ROCK2/PLA2G2D/EDN3/PLCB1/PPP1CA/ADCY9/PLA2G4B/ITPR2 21 KEGG hsa04216 Ferroptosis 7/1171 41/8135 0.3762 0.6508 0.4999 PCBP1/PRNP/PCBP2/ALOX15/TF/GCLM/SLC3A2 7 KEGG hsa00650 Butanoate metabolism 5/1171 28/8135 0.3772 0.6508 0.4999 HADH/ECHS1/HMGCL/OXCT1/OXCT2 5 KEGG hsa04916 Melanogenesis 16/1171 101/8135 0.3803 0.6528 0.5015 CALM3/CREB1/CALM1/ADCY7/MAP2K1/ADCY4/GSK3B/LEF1/TCF7L2/FZD9/MC1R/WNT10A/PLCB1/ADCY9/WNT1/FZD6 16 KEGG hsa04150 mTOR signaling pathway 24/1171 156/8135 0.3954 0.6733 0.5172 RRAGD/ATP6V1D/WDR59/LPIN1/TELO2/IKBKB/GRB10/MAP2K1/ATP6V1E2/GSK3B/PIK3CB/PIK3R2/TNF/RHEB/PTEN/FZD9/WNT10A/ATP6V1B1/WNT1/ATP6V1G3/ATP6V1E1/FZD6/SLC3A2/PIK3R3 24 KEGG hsa04914 Progesterone-mediated oocyte maturation 16/1171 102/8135 0.3963 0.6733 0.5172 CPEB3/ADCY7/MAP2K1/ANAPC5/MAPK12/ANAPC1/ADCY4/CDK2/MAPK9/HSP90AB1/PIK3CB/PIK3R2/CDC23/ADCY9/MAPK13/PIK3R3 16 KEGG hsa04151 PI3K-Akt signaling pathway 53/1171 354/8135 0.3995 0.6753 0.5187 GNB1/IL2RB/RBL2/CDC37/PPP2R3C/CREB1/JAK1/FASLG/IKBKB/GHR/MAP2K1/G6PC3/PPP2R5A/CSF1R/PPP2CB/ITGA4/IKBKG/CDK2/PPP2R1A/ATF2/GSK3B/PPP2R2A/TLR2/HSP90B1/HSP90AB1/PIK3CB/CDKN1B/THBS1/PPP2R3A/TLR4/PIK3R2/YWHAQ/RHEB/FLT3/PTEN/GNG11/PCK1/MYC/GNG5/COL4A3/EPO/EPHA2/GNB4/ANGPT1/VTN/IFNA2/COL9A2/TCL1B/F2R/YWHAH/SPP1/IFNAR1/PIK3R3 53 KEGG hsa04390 Hippo signaling pathway 24/1171 157/8135 0.4084 0.6841 0.5255 SMAD7/ACTG1/SCRIB/LLGL1/PPP2CB/AXIN2/PPP2R1A/CSNK1E/TGFBR1/GSK3B/PPP2R2A/LEF1/AXIN1/TCF7L2/YWHAQ/FZD9/TP53BP2/MYC/WNT10A/PPP1CA/SMAD3/WNT1/FZD6/YWHAH 24 KEGG hsa04014 Ras signaling pathway 35/1171 232/8135 0.4091 0.6841 0.5255 GNB1/CALM3/ETS1/CALM1/FASLG/RALGDS/IKBKB/RASA3/MAP2K1/CSF1R/IKBKG/RAC2/MAPK9/PAK4/RGL2/PIK3CB/RRAS/PAK1/EXOC2/PIK3R2/PLA2G2D/RASSF5/FLT3/GNG11/PLCG1/BRAP/GNG5/MRAS/EPHA2/GNB4/ANGPT1/ARF6/PLA2G4B/SHC1/PIK3R3 35 KEGG hsa00360 Phenylalanine metabolism 3/1171 16/8135 0.4109 0.6841 0.5255 GOT1/GOT2/MAOA 3 KEGG hsa00760 Nicotinate and nicotinamide metabolism 6/1171 36/8135 0.4182 0.6844 0.5257 ENPP3/NNT/BST1/NT5C1B/NADSYN1/NMNAT3 6 KEGG hsa00310 Lysine degradation 10/1171 63/8135 0.4221 0.6844 0.5257 ALDH9A1/HADH/ECHS1/PLOD2/ALDH3A2/SETD1A/SETD2/SMYD2/SUV39H1/GCDH 10 KEGG hsa03250 Viral life cycle - HIV-1 10/1171 63/8135 0.4221 0.6844 0.5257 AFF4/NUP153/CD4/RAN/HGS/MX2/TNPO3/SAMHD1/SUPT4H1/SUPT5H 10 KEGG hsa05217 Basal cell carcinoma 10/1171 63/8135 0.4221 0.6844 0.5257 AXIN2/GSK3B/LEF1/AXIN1/TCF7L2/FZD9/WNT10A/BAK1/WNT1/FZD6 10 KEGG hsa04975 Fat digestion and absorption 7/1171 43/8135 0.4263 0.6844 0.5257 ABCA1/DGAT1/GOT2/SCARB1/AGPAT2/PLA2G2D/ABCG5 7 KEGG hsa04622 RIG-I-like receptor signaling pathway 11/1171 70/8135 0.427 0.6844 0.5257 IKBKB/MAPK12/CASP8/IKBKG/MAPK9/FADD/TRIM25/TNF/CYLD/IFNA2/MAPK13 11 KEGG hsa03430 Mismatch repair 4/1171 23/8135 0.4272 0.6844 0.5257 RPA1/POLD2/MLH1/RPA3 4 KEGG hsa04915 Estrogen signaling pathway 21/1171 138/8135 0.4275 0.6844 0.5257 CALM3/CREB1/CALM1/MMP9/ADCY7/MAP2K1/ADCY4/ITPR3/ATF2/HSP90B1/HSP90AB1/PIK3CB/PIK3R2/FKBP5/KRT18/HSPA6/PLCB1/ADCY9/SHC1/PIK3R3/ITPR2 21 KEGG hsa00920 Sulfur metabolism 2/1171 10/8135 0.4333 0.6903 0.5302 SUOX/MPST 2 KEGG hsa00053 Ascorbate and aldarate metabolism 5/1171 30/8135 0.4378 0.6903 0.5302 ALDH9A1/ALDH3A2/GUSB/UGT2B28/UGT1A5 5 KEGG hsa01212 Fatty acid metabolism 9/1171 57/8135 0.4381 0.6903 0.5302 HADH/ECHS1/FASN/CPT2/FADS1/ACADM/CPT1A/ACOX3/HSD17B12 9 KEGG hsa01522 Endocrine resistance 15/1171 98/8135 0.4415 0.6903 0.5302 MMP9/ADCY7/MAP2K1/MAPK12/ADCY4/MAPK9/PIK3CB/CDKN1B/PIK3R2/RB1/DLL1/ADCY9/SHC1/MAPK13/PIK3R3 15 KEGG hsa05231 Choline metabolism in cancer 15/1171 98/8135 0.4415 0.6903 0.5302 RALGDS/MAP2K1/RAC2/LYPLA1/MAPK9/SLC22A4/SLC22A1/PIK3CB/WASF2/PIK3R2/RHEB/PLCG1/DGKI/PLA2G4B/PIK3R3 15 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 16/1171 106/8135 0.4604 0.7106 0.5459 CREB1/GATA3/SLC9A3R1/ADCY7/MAP2K1/PDE4B/ADCY4/ITPR3/ATF2/EGR1/MEF2D/TRPV5/MAFB/PLCB1/ADCY9/ITPR2 16 KEGG hsa04977 Vitamin digestion and absorption 4/1171 24/8135 0.4612 0.7106 0.5459 SLC23A1/SCARB1/SLC19A1/MMACHC 4 KEGG hsa04725 Cholinergic synapse 17/1171 113/8135 0.4624 0.7106 0.5459 GNB1/CREB1/ADCY7/MAP2K1/FYN/ADCY4/ITPR3/PIK3CB/PIK3R2/CACNA1A/GNG11/GNG5/PLCB1/GNB4/ADCY9/PIK3R3/ITPR2 17 KEGG hsa04927 Cortisol synthesis and secretion 10/1171 65/8135 0.4631 0.7106 0.5459 CREB1/ADCY7/ADCY4/ITPR3/SCARB1/ATF2/NR5A1/PLCB1/ADCY9/ITPR2 10 KEGG hsa00052 Galactose metabolism 5/1171 31/8135 0.4676 0.7143 0.5487 HK3/G6PC3/PFKP/HK2/AKR1B1 5 KEGG hsa04530 Tight junction 25/1171 169/8135 0.4746 0.7215 0.5542 MYL6B/ARHGAP17/MYL6/TJAP1/ACTG1/SLC9A3R1/SCRIB/LLGL1/CLDN9/PPP2CB/PPP2R1A/PRKAG2/PPP2R2A/VASP/ARPC3/MAPK9/ROCK2/TUBA1C/ARHGEF18/TUBA1B/ACTR2/RAPGEF6/RAB13/ARPC5L/CD1D 25 KEGG hsa04724 Glutamatergic synapse 17/1171 114/8135 0.4779 0.7215 0.5542 GNB1/ADCY7/GRM3/ADCY4/PPP3CC/ITPR3/GRM8/GLS2/CACNA1A/GLS/GNG11/GNG5/PLCB1/GNB4/ADCY9/PLA2G4B/ITPR2 17 KEGG hsa00600 Sphingolipid metabolism 8/1171 52/8135 0.4788 0.7215 0.5542 UGCG/CERK/SPHK2/SMPD2/GBA/NEU2/ARSA/SGPP1 8 KEGG hsa04115 p53 signaling pathway 11/1171 73/8135 0.4853 0.728 0.5592 CASP8/CDK2/COP1/THBS1/PTEN/TP53I3/EI24/ATM/GTSE1/RRM2/IGFBP3 11 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 22/1171 150/8135 0.4978 0.7434 0.571 CALM3/PPP2R3C/CREB1/CALM1/ADCY7/PPP2R5A/MAPK12/ADCY4/PPP2CB/PPP2R1A/ATF2/PPP2R2A/CACNG6/CACNA2D2/TPM3/PPP2R3A/TPM4/CACNG4/PLCB1/PPP1CA/ADCY9/MAPK13 22 KEGG hsa04730 Long-term depression 9/1171 60/8135 0.5026 0.7472 0.574 MAP2K1/PPP2CB/ITPR3/PPP2R1A/CACNA1A/PLCB1/PLA2G4B/ITPR2/CRH 9 KEGG hsa04918 Thyroid hormone synthesis 11/1171 75/8135 0.5235 0.7682 0.5901 TTF2/CREB1/ADCY7/PDIA4/ADCY4/ITPR3/ATF2/HSP90B1/PLCB1/ADCY9/ITPR2 11 KEGG hsa05214 Glioma 11/1171 75/8135 0.5235 0.7682 0.5901 CALM3/CALM1/MAP2K1/PIK3CB/PIK3R2/PTEN/PLCG1/RB1/BAK1/SHC1/PIK3R3 11 KEGG hsa00561 Glycerolipid metabolism 9/1171 61/8135 0.5237 0.7682 0.5901 ALDH9A1/AGK/LPIN1/DGAT1/ALDH3A2/AGPAT2/PNPLA3/AKR1B1/DGKI 9 KEGG hsa00790 Folate biosynthesis 4/1171 26/8135 0.5269 0.7696 0.5911 QDPR/GCH1/AKR1B1/PCBD2 4 KEGG hsa04971 Gastric acid secretion 11/1171 76/8135 0.5423 0.7811 0.6 CALM3/ACTG1/CALM1/ADCY7/KCNJ15/ADCY4/ITPR3/CA2/PLCB1/ADCY9/ITPR2 11 KEGG hsa05031 Amphetamine addiction 10/1171 69/8135 0.5432 0.7811 0.6 CALM3/HDAC1/CREB1/CALM1/PPP3CC/ATF2/SLC18A2/MAOA/PPP1CA/STX1A 10 KEGG hsa05211 Renal cell carcinoma 10/1171 69/8135 0.5432 0.7811 0.6 CRKL/ETS1/MAP2K1/RBX1/PAK4/PIK3CB/PAK1/PIK3R2/CUL2/PIK3R3 10 KEGG hsa04213 Longevity regulating pathway - multiple species 9/1171 62/8135 0.5444 0.7811 0.6 HDAC1/ADCY7/ADCY4/PRKAG2/PIK3CB/PIK3R2/HSPA6/ADCY9/PIK3R3 9 KEGG hsa03440 Homologous recombination 6/1171 41/8135 0.5503 0.7811 0.6 RPA1/POLD2/RPA3/RAD54B/BARD1/ATM 6 KEGG hsa05219 Bladder cancer 6/1171 41/8135 0.5503 0.7811 0.6 MMP9/MAP2K1/THBS1/MYC/RB1/DAPK2 6 KEGG hsa05224 Breast cancer 21/1171 147/8135 0.5516 0.7811 0.6 MAP2K1/AXIN2/CSNK1A1/GSK3B/LEF1/PIK3CB/PIK3R2/AXIN1/TCF7L2/PTEN/FZD9/MYC/WNT10A/RB1/DLL1/BAK1/FRAT1/WNT1/FZD6/SHC1/PIK3R3 21 KEGG hsa00040 Pentose and glucuronate interconversions 5/1171 34/8135 0.5536 0.7811 0.6 AKR1B1/CRYL1/GUSB/UGT2B28/UGT1A5 5 KEGG hsa04925 Aldosterone synthesis and secretion 14/1171 98/8135 0.5566 0.7811 0.6 CALM3/CREB1/DAGLA/CALM1/ADCY7/ADCY4/ITPR3/SCARB1/ATF2/DAGLB/PLCB1/ADCY9/ITPR2/LIPE 14 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/1171 27/8135 0.5582 0.7811 0.6 FUT7/B3GNT2/ST3GAL6/FUT3 4 KEGG hsa04917 Prolactin signaling pathway 10/1171 70/8135 0.5626 0.7839 0.6021 IRF1/MAP2K1/MAPK12/GSK3B/MAPK9/PIK3CB/PIK3R2/SHC1/MAPK13/PIK3R3 10 KEGG hsa05222 Small cell lung cancer 13/1171 92/8135 0.5746 0.7973 0.6124 IKBKB/CKS2/IKBKG/CDK2/PIK3CB/CDKN1B/PIK3R2/PTEN/MYC/COL4A3/RB1/BAK1/PIK3R3 13 KEGG hsa04929 GnRH secretion 9/1171 64/8135 0.5848 0.8081 0.6207 MAP2K1/ITPR3/PIK3CB/PIK3R2/PLCB1/KCNN3/SPP1/PIK3R3/ITPR2 9 KEGG hsa00860 Porphyrin metabolism 6/1171 43/8135 0.5992 0.8227 0.6319 EARS2/GUSB/UROS/UGT2B28/UGT1A5/HCCS 6 KEGG hsa05223 Non-small cell lung cancer 10/1171 72/8135 0.6003 0.8227 0.6319 MAP2K1/PIK3CB/PIK3R2/RASSF5/PLCG1/RB1/KIF5B/BAK1/EML4/PIK3R3 10 KEGG hsa00562 Inositol phosphate metabolism 10/1171 73/8135 0.6186 0.8428 0.6474 MTM1/PIK3CB/ALDH6A1/INPP5A/INPP1/PTEN/IPPK/PLCG1/PLCB1/MTMR3 10 KEGG hsa05146 Amoebiasis 14/1171 102/8135 0.6201 0.8428 0.6474 ARG1/TLR2/PIK3CB/IL1R2/TLR4/PIK3R2/CTSG/TNF/IFNG/COL4A3/IL1B/PLCB1/CD1D/PIK3R3 14 KEGG hsa04540 Gap junction 12/1171 88/8135 0.6272 0.849 0.6521 ADCY7/MAP2K1/ADCY4/ITPR3/TUBB8/MAPK7/TUBA1C/TUBA1B/MAP3K2/PLCB1/ADCY9/ITPR2 12 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 5/1171 37/8135 0.6321 0.8522 0.6546 GOT1/GOT2/GLS2/GLS/ASNS 5 KEGG hsa05414 Dilated cardiomyopathy 13/1171 96/8135 0.639 0.8581 0.6591 ACTG1/ADCY7/ADCY4/ITGA4/EMD/CACNG6/CACNA2D2/TPM3/TNF/TPM4/CACNG4/ADCY9/SGCA 13 KEGG hsa04613 Neutrophil extracellular trap formation 26/1171 190/8135 0.6429 0.8591 0.6599 CAMP/SLC25A5/ACTG1/HDAC1/VDAC1/NCF4/MAP2K1/MAPK12/AZU1/PADI4/RAC2/TLR2/HDAC3/PIK3CB/CLEC7A/TLR4/PIK3R2/MPO/CTSG/PLCG1/ITGAL/PLCB1/AGER/HDAC8/MAPK13/PIK3R3 26 KEGG hsa00030 Pentose phosphate pathway 4/1171 30/8135 0.645 0.8591 0.6599 PFKP/GPI/FBP1/G6PD 4 KEGG hsa04713 Circadian entrainment 13/1171 97/8135 0.6543 0.8661 0.6653 GNB1/CALM3/CREB1/CALM1/ADCY7/ADCY4/ITPR3/RASD1/GNG11/GNG5/PLCB1/GNB4/ADCY9 13 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/1171 15/8135 0.658 0.8661 0.6653 B3GALT4/ST3GAL5 2 KEGG hsa00730 Thiamine metabolism 2/1171 15/8135 0.658 0.8661 0.6653 AK1/ACP1 2 KEGG hsa04614 Renin-angiotensin system 3/1171 23/8135 0.6635 0.8698 0.6682 PREP/CPA3/CTSG 3 KEGG hsa04924 Renin secretion 9/1171 69/8135 0.6777 0.8798 0.6758 CALM3/CREB1/CALM1/PPP3CC/ITPR3/EDN3/PTGER2/PLCB1/ITPR2 9 KEGG hsa04144 Endocytosis 34/1171 251/8135 0.6789 0.8798 0.6758 RAB11FIP3/IL2RB/AP2B1/VPS25/ARF1/RAB11FIP5/ARF4/ARFGAP3/VPS37C/CHMP5/BIN1/TGFBR1/RAB22A/ARPC3/SNX5/HGS/CHMP1B/VPS35/WIPF2/VPS26B/DNM2/CAPZA2/SH3GLB1/SNX1/HSPA6/ACTR2/SNF8/KIF5B/VPS29/ARPC5L/SMURF2/SMAD3/ARF6/STAM 34 KEGG hsa04919 Thyroid hormone signaling pathway 16/1171 121/8135 0.6833 0.8798 0.6758 ACTG1/HDAC1/SIN3A/MAP2K1/PFKP/GSK3B/HDAC3/PIK3CB/PIK3R2/PFKFB2/RHEB/PLCG1/MYC/SLC16A10/PLCB1/PIK3R3 16 KEGG hsa04510 Focal adhesion 27/1171 201/8135 0.6834 0.8798 0.6758 CRKL/ACTG1/MAP2K1/FYN/ITGA4/PPP1R12C/RAC2/GSK3B/VASP/MAPK9/PAK4/PPP1R12B/PIK3CB/ROCK2/THBS1/FLNB/PAK1/PIK3R2/PTEN/COL4A3/PPP1CA/VTN/COL9A2/MYL7/SHC1/SPP1/PIK3R3 27 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 19/1171 143/8135 0.6843 0.8798 0.6758 JAK1/MAP2K1/MAPK12/AXIN2/GSK3B/PIK3CB/PCGF6/PIK3R2/AXIN1/TCF3/FZD9/MYC/WNT10A/ID3/SMAD3/WNT1/FZD6/MAPK13/PIK3R3 19 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 10/1171 77/8135 0.6871 0.88 0.6759 ACTG1/ITGA4/LEF1/EMD/CACNG6/CACNA2D2/TCF7L2/CACNG4/DSG2/SGCA 10 KEGG hsa04726 Serotonergic synapse 15/1171 115/8135 0.701 0.8943 0.687 GNB1/MAP2K1/ITPR3/CACNA1A/SLC18A2/MAOA/GNG11/GNG5/PLCB1/GNB4/ALOX15/CYP4X1/PLA2G4B/ALOX15B/ITPR2 15 KEGG hsa04970 Salivary secretion 12/1171 93/8135 0.704 0.8948 0.6874 CAMP/CALM3/CALM1/ADCY7/CST3/ADCY4/ITPR3/PLCB1/BST1/ADCY9/LYZ/ITPR2 12 KEGG hsa04810 Regulation of actin cytoskeleton 29/1171 218/8135 0.7081 0.8965 0.6887 CRKL/ACTG1/PFN1/CFL1/MAP2K1/SSH1/ITGA4/PPP1R12C/RAC2/ARPC3/PAK4/PPP1R12B/PIK3CB/ROCK2/WASF2/RRAS/PAK1/PIK3R2/CXCL12/ACTR2/MRAS/ITGAL/PPP1CA/ARPC5L/ARHGEF6/MYL7/F2R/SPATA13/PIK3R3 29 KEGG hsa05203 Viral carcinogenesis 27/1171 204/8135 0.7134 0.8965 0.6887 SRF/DNAJA3/GTF2B/RBL2/HDAC1/CREB1/JAK1/SCRIB/TBP/CASP8/IKBKG/CDK2/SND1/ATF2/HDAC3/PIK3CB/CDKN1B/EIF2AK2/PIK3R2/YWHAQ/RB1/HDAC8/BAK1/RBL1/MAPKAPK2/YWHAH/PIK3R3 27 KEGG hsa04923 Regulation of lipolysis in adipocytes 7/1171 56/8135 0.7142 0.8965 0.6887 ADCY7/ADCY4/PIK3CB/PIK3R2/ADCY9/PIK3R3/LIPE 7 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 10/1171 79/8135 0.7183 0.8965 0.6887 JAK1/MAP2K1/GSK3B/PIK3CB/PIK3R2/GAS6/PTEN/PLCG1/SHC1/PIK3R3 10 KEGG hsa00592 alpha-Linolenic acid metabolism 3/1171 25/8135 0.7194 0.8965 0.6887 PLA2G2D/ACOX3/PLA2G4B 3 KEGG hsa00120 Primary bile acid biosynthesis 2/1171 17/8135 0.7256 0.8965 0.6887 AMACR/ACOX2 2 KEGG hsa00450 Selenocompound metabolism 2/1171 17/8135 0.7256 0.8965 0.6887 MARS2/MTR 2 KEGG hsa05030 Cocaine addiction 6/1171 49/8135 0.7269 0.8965 0.6887 CREB1/GRM3/CDK5R1/ATF2/SLC18A2/MAOA 6 KEGG hsa05150 Staphylococcus aureus infection 12/1171 96/8135 0.7451 0.9131 0.7013 CAMP/HLA-DPA1/HLA-DMA/HLA-DRB4/DEFA4/HLA-DPB1/ICAM1/HLA-DMB/KRT18/DEFA5/ITGAL/HLA-DOA 12 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 8/1171 66/8135 0.7526 0.9131 0.7013 YARS2/IARS2/RARS2/MARS2/VARS2/EARS2/LARS2/FARSA 8 KEGG hsa04211 Longevity regulating pathway 11/1171 89/8135 0.7528 0.9131 0.7013 CREB1/ADCY7/ADCY4/PRKAG2/ATF2/PIK3CB/PIK3R2/RHEB/CAMKK2/ADCY9/PIK3R3 11 KEGG hsa04727 GABAergic synapse 11/1171 89/8135 0.7528 0.9131 0.7013 GNB1/ADCY7/ADCY4/TRAK2/GLS2/CACNA1A/GLS/GNG11/GNG5/GNB4/ADCY9 11 KEGG hsa00061 Fatty acid biosynthesis 2/1171 18/8135 0.7549 0.9131 0.7013 FASN/ACACB 2 KEGG hsa04913 Ovarian steroidogenesis 6/1171 51/8135 0.7625 0.9131 0.7013 ADCY7/ADCY4/SCARB1/ADCY9/CYP1B1/PLA2G4B 6 KEGG hsa05410 Hypertrophic cardiomyopathy 11/1171 90/8135 0.7658 0.9131 0.7013 ACTG1/ITGA4/PRKAG2/EMD/CACNG6/CACNA2D2/TPM3/TNF/TPM4/CACNG4/SGCA 11 KEGG hsa04720 Long-term potentiation 8/1171 67/8135 0.7676 0.9131 0.7013 CALM3/CALM1/MAP2K1/PPP3CC/ITPR3/PLCB1/PPP1CA/ITPR2 8 KEGG hsa00062 Fatty acid elongation 3/1171 27/8135 0.7677 0.9131 0.7013 HADH/ECHS1/HSD17B12 3 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 3/1171 27/8135 0.7677 0.9131 0.7013 FADS1/ACOX3/HSD17B12 3 KEGG hsa00350 Tyrosine metabolism 4/1171 36/8135 0.7821 0.9266 0.7118 GOT1/COMT/GOT2/MAOA 4 KEGG hsa05207 Chemical carcinogenesis - receptor activation 27/1171 212/8135 0.7847 0.9266 0.7118 GSTO1/CREB1/ADCY7/MAP2K1/ADCY4/ATF2/HSP90B1/HSP90AB1/PIK3CB/PAQR8/MGST3/PAQR7/PIK3R2/CACNA1A/GSTO2/MYC/RB1/DLL1/GSTM4/ADCY9/WNT1/CYP1B1/UGT2B28/KPNA1/EPHX2/UGT1A5/PIK3R3 27 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 8/1171 69/8135 0.7956 0.9334 0.717 GSTO1/GSTP1/MGST3/GSTO2/GSTM4/CYP1B1/UGT2B28/UGT1A5 8 KEGG hsa02010 ABC transporters 5/1171 45/8135 0.796 0.9334 0.717 ABCA1/ABCB1/TAP1/TAP2/ABCG5 5 KEGG hsa00591 Linoleic acid metabolism 3/1171 29/8135 0.8091 0.9379 0.7205 PLA2G2D/ALOX15/PLA2G4B 3 KEGG hsa04744 Phototransduction 3/1171 29/8135 0.8091 0.9379 0.7205 GNB1/CALM3/CALM1 3 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 9/1171 78/8135 0.8096 0.9379 0.7205 AKR7A2/GSTO1/GSTP1/MGST3/GSTO2/GSTM4/CYP1B1/UGT2B28/UGT1A5 9 KEGG hsa04911 Insulin secretion 10/1171 86/8135 0.8112 0.9379 0.7205 CREB1/ADCY7/ADCY4/ITPR3/ATF2/PDX1/PLCB1/KCNN3/ADCY9/STX1A 10 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 1/1171 11/8135 0.8193 0.944 0.7251 COQ7 1 KEGG hsa00982 Drug metabolism - cytochrome P450 8/1171 72/8135 0.8327 0.9562 0.7345 GSTO1/GSTP1/MGST3/GSTO2/MAOA/GSTM4/UGT2B28/UGT1A5 8 KEGG hsa04340 Hedgehog signaling pathway 6/1171 56/8135 0.8361 0.9567 0.7348 CSNK1A1/CSNK1E/GSK3B/CUL1/CUL3/SMURF2 6 KEGG hsa04976 Bile secretion 10/1171 89/8135 0.8432 0.9567 0.7348 ADCY7/ADCY4/ABCB1/SCARB1/CA2/SLC22A1/ABCG5/ADCY9/UGT2B28/UGT1A5 10 KEGG hsa04022 cGMP-PKG signaling pathway 20/1171 167/8135 0.8444 0.9567 0.7348 SRF/CALM3/SLC25A5/VDAC1/CREB1/CALM1/ADCY7/MAP2K1/ADCY4/NFATC3/PPP3CC/ITPR3/ATF2/VASP/ROCK2/MEF2D/PLCB1/PPP1CA/ADCY9/ITPR2 20 KEGG hsa00900 Terpenoid backbone biosynthesis 2/1171 22/8135 0.8465 0.9567 0.7348 FNTA/ICMT 2 KEGG hsa00260 Glycine, serine and threonine metabolism 4/1171 40/8135 0.8475 0.9567 0.7348 SHMT1/CBS/SHMT2/MAOA 4 KEGG hsa00565 Ether lipid metabolism 5/1171 49/8135 0.8532 0.9599 0.7373 GDPD3/PAFAH1B1/AGPS/PLA2G2D/PLA2G4B 5 KEGG hsa03320 PPAR signaling pathway 8/1171 75/8135 0.8643 0.9691 0.7444 DBI/CPT2/OLR1/PCK1/ACADM/CPT1A/ACOX2/ACOX3 8 KEGG hsa03450 Non-homologous end-joining 1/1171 13/8135 0.8676 0.9695 0.7447 PRKDC 1 KEGG hsa00830 Retinol metabolism 7/1171 68/8135 0.8766 0.9738 0.748 DGAT1/DHRS3/RDH8/RDH10/RDH16/UGT2B28/UGT1A5 7 KEGG hsa05168 Herpes simplex virus 1 infection 63/1171 495/8135 0.8773 0.9738 0.748 CD74/SRPK1/ZNF212/EIF2B1/ZNF317/JAK1/HLA-DPA1/FASLG/IKBKB/TICAM1/HLA-DMA/ZNF324B/ZNF689/CASP8/ZNF641/TNFRSF14/HLA-DRB4/ZNF273/IKBKG/ZNF792/ZNF564/HLA-DPB1/ZNF324/TLR2/ZNF621/ZNF699/PIK3CB/POU2F2/NXF1/FADD/EIF2AK2/ZNF777/TAP1/PIK3R2/TAP2/HLA-DMB/TNF/ZNF214/RHEB/ZNF432/ZNF354A/ZNF45/ZFP57/ZNF20/IFNG/ZNF548/IL1B/ZNF420/CARD9/HLA-DOA/PPP1CA/ZNF549/BAK1/IFNA2/ZNF25/TNFSF14/ZNF133/CCL5/IFNAR1/ZNF563/PIK3R3/ZNF253/ZNF300 63 KEGG hsa04972 Pancreatic secretion 11/1171 102/8135 0.8858 0.9777 0.751 ADCY7/ADCY4/ITPR3/CA2/CPA3/PLA2G2D/CTRL/PLCB1/BST1/ADCY9/ITPR2 11 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/1171 14/8135 0.8867 0.9777 0.751 B3GNT2 1 KEGG hsa00590 Arachidonic acid metabolism 6/1171 61/8135 0.8902 0.9783 0.7515 PLA2G2D/PTGES/ALOX15/PLA2G4B/ALOX15B/EPHX2 6 KEGG hsa04962 Vasopressin-regulated water reabsorption 4/1171 44/8135 0.8955 0.9787 0.7518 CREB1/DYNC1H1/ARHGDIA/ADCY9 4 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 5/1171 53/8135 0.8964 0.9787 0.7518 AP2B1/DNM2/TRPV5/PLCB1/ADCY9 5 KEGG hsa03460 Fanconi anemia pathway 5/1171 54/8135 0.9053 0.9836 0.7556 RPA1/MLH1/TELO2/REV1/RPA3 5 KEGG hsa04630 JAK-STAT signaling pathway 18/1171 162/8135 0.9096 0.9836 0.7556 IL2RB/IL10RA/JAK1/PIAS3/IL27RA/GHR/IL12RB1/PIK3CB/PIK3R2/IL12RB2/MYC/IFNG/EPO/IFNA2/STAM/IFNAR1/PIK3R3/CSF2RA 18 KEGG hsa05218 Melanoma 7/1171 72/8135 0.9098 0.9836 0.7556 MAP2K1/PIK3CB/PIK3R2/PTEN/RB1/BAK1/PIK3R3 7 KEGG hsa00430 Taurine and hypotaurine metabolism 1/1171 16/8135 0.917 0.9845 0.7563 CSAD 1 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 3/1171 37/8135 0.9176 0.9845 0.7563 PIK3CB/PIK3R2/PIK3R3 3 KEGG hsa00514 Other types of O-glycan biosynthesis 4/1171 47/8135 0.9222 0.9845 0.7563 MFNG/ST6GAL1/GALNT4/LFNG 4 KEGG hsa05032 Morphine addiction 9/1171 91/8135 0.9224 0.9845 0.7563 GNB1/ADCY7/PDE4B/ADCY4/CACNA1A/GNG11/GNG5/GNB4/ADCY9 9 KEGG hsa04392 Hippo signaling pathway - multiple species 2/1171 29/8135 0.9355 0.9953 0.7645 CSNK1E/PAK1 2 KEGG hsa00531 Glycosaminoglycan degradation 1/1171 19/8135 0.948 1 0.7681 GUSB 1 KEGG hsa00140 Steroid hormone biosynthesis 5/1171 61/8135 0.9509 1 0.7681 COMT/CYP1B1/HSD17B12/UGT2B28/UGT1A5 5 KEGG hsa04024 cAMP signaling pathway 24/1171 221/8135 0.9511 1 0.7681 CALM3/CREB1/CALM1/ADCY7/MAP2K1/PDE4B/ADCY4/RAC2/MAPK9/PIK3CB/ROCK2/RRAS/PAK1/PIK3R2/SOX9/EDN3/PTGER2/PPP1CA/ACOX3/ADCY9/F2R/PIK3R3/LIPE/CRH 24 KEGG hsa00100 Steroid biosynthesis 1/1171 20/8135 0.9555 1 0.7681 LIPA 1 KEGG hsa05034 Alcoholism 19/1171 187/8135 0.9668 1 0.7681 GNB1/CALM3/HDAC1/CREB1/CALM1/MAP2K1/ATF2/HDAC3/SLC18A2/CAMKK2/MAOA/GNG11/GNG5/SLC29A1/PPP1CA/GNB4/HDAC8/SHC1/CRH 19 KEGG hsa00515 Mannose type O-glycan biosynthesis 1/1171 23/8135 0.9721 1 0.7681 FKRP 1 KEGG hsa00564 Glycerophospholipid metabolism 8/1171 98/8135 0.9789 1 0.7681 LPIN1/TAZ/LYPLA1/AGPAT2/LPGAT1/PLA2G2D/DGKI/PLA2G4B 8 KEGG hsa04978 Mineral absorption 4/1171 60/8135 0.9804 1 0.7681 TRPM6/MT1M/MT1X/TF 4 KEGG hsa04950 Maturity onset diabetes of the young 1/1171 26/8135 0.9825 1 0.7681 PDX1 1 KEGG hsa04974 Protein digestion and absorption 8/1171 103/8135 0.9866 1 0.7681 COL17A1/CPA3/CTRL/SLC7A9/COL4A3/SLC16A10/COL9A2/SLC3A2 8 KEGG hsa04512 ECM-receptor interaction 6/1171 88/8135 0.9913 1 0.7681 ITGA4/THBS1/COL4A3/VTN/COL9A2/SPP1 6 KEGG hsa05322 Systemic lupus erythematosus 11/1171 136/8135 0.9915 1 0.7681 HLA-DPA1/SNRPB/HLA-DMA/CD40LG/HLA-DRB4/HLA-DPB1/CTSG/HLA-DMB/TNF/IFNG/HLA-DOA 11 KEGG hsa04610 Complement and coagulation cascades 5/1171 85/8135 0.9961 1 0.7681 F5/CR2/THBD/VTN/F2R 5 KEGG hsa00512 Mucin type O-glycan biosynthesis 1/1171 36/8135 0.9963 1 0.7681 GALNT4 1 KEGG hsa05033 Nicotine addiction 1/1171 40/8135 0.998 1 0.7681 CACNA1A 1 KEGG hsa04742 Taste transduction 4/1171 86/8135 0.9991 1 0.7681 ADCY4/ITPR3/CACNA1A/PLCB1 4 KEGG hsa04020 Calcium signaling pathway 19/1171 240/8135 0.9993 1 0.7681 CALM3/SLC25A5/VDAC1/CALM1/ADCY7/STIM2/ADCY4/MCOLN2/PPP3CC/ITPR3/SPHK2/PHKA2/CACNA1A/PLCG1/PLCB1/TNNC2/ADCY9/F2R/ITPR2 19 KEGG hsa05206 MicroRNAs in cancer 25/1171 310/8135 0.9998 1 0.7681 DNMT1/CRKL/HDAC1/MMP9/IKBKB/SLC45A3/MAP2K1/ABCB1/BCL2L2/PAK4/MAPK7/PIK3CB/CDKN1B/GLS2/THBS1/PIK3R2/GLS/PTEN/PLCG1/MYC/BAK1/CYP1B1/ATM/SHC1/PIK3R3 25 KEGG hsa04080 Neuroactive ligand-receptor interaction 18/1171 353/8135 1 1 0.7681 GHR/PTGDR/NMUR1/GRM3/GRM8/GALR2/CHRNA10/CALCA/CTSG/P2RY13/NPB/P2RY11/EDN3/MC1R/PTGER2/F2R/CRH/LTB4R 18 KEGG hsa04740 Olfactory transduction 19/1171 440/8135 1 1 0.7681 GNB1/CALM3/CALM1/OR7E24/OR6C6/OR7G2/OR2T1/OR10A5/OR13C5/NCALD/OR2M7/OR2B11/OR5C1/OR4D1/OR7D4/OR4M2/OR5T1/OR4F21/OR4K1 19