ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count BP GO:0050900 leukocyte migration 88/1096 499/18670 7.222e-21 2.108e-17 1.43e-17 PLCB1/GPSM3/CXCR4/CCL5/ADAM8/RAC2/ITGB7/RARRES2/CXCL13/ANGPT1/CORO1A/CCL13/TGFB2/VEGFA/ITGAV/CD200/TNFRSF10B/IL1RN/CH25H/LCK/ICAM1/ADA/GATA3/PTK2B/ITGAX/CD48/IL1B/CCL18/CD2/CCR7/S1PR1/SDC1/MAPK3/ADORA1/SELPLG/PTPN6/GPR183/IL27RA/CXCL8/ITGAL/S100A9/PTAFR/CCR5/CD44/CXCL1/SLC7A8/ITGA4/COL1A1/SLC7A5/CX3CR1/GAS6/CCR2/CXCL6/THY1/STK10/ITGA5/PECAM1/IGKC/SELL/CCR6/NCKAP1L/IL17RA/PLA2G7/PF4/CXCL3/OLR1/SERPINE1/CXCL10/IGLV6-57/MTUS1/LBP/CXCL12/ABR/THBS4/ARHGEF5/INPP5D/VAV1/TNFSF14/IGLC1/LGMN/ITGB2/C3AR1/ANGPT2/CCL2/SELP/ELANE/CCL7/FLT1 88 BP GO:0007159 leukocyte cell-cell adhesion 70/1096 337/18670 7.41e-21 2.108e-17 1.43e-17 RUNX3/IL4R/ZBTB16/CCL5/ADAM8/RAC2/ITGB7/IL7R/CORO1A/RASGRP1/LILRB2/LCK/ICAM1/ADA/IRF1/GATA3/FCGR2B/IL1B/CCR7/PAK1/XBP1/LILRB4/SELPLG/PTPN6/ITGAL/ASS1/S100A9/PTAFR/CD44/PTPRC/CD83/ITGA4/PAK2/EGR3/CD27/CX3CR1/DLG5/SKAP1/CCR2/PTPN22/THY1/STK10/BMP4/ITGA5/IGFBP2/PECAM1/SELL/ZMIZ1/NCKAP1L/LAG3/BAD/HLA-DMB/CD86/CSK/CXCL12/NLRP3/VAV1/TFRC/TNFSF14/ITGB2/DUSP3/PTPN2/SART1/CCL2/IL2RA/PRDX2/SELP/ELANE/IL15/GLMN 70 BP GO:0042110 T cell activation 79/1096 464/18670 6.662e-18 1.264e-14 8.572e-15 RUNX3/CD3D/TNFRSF1B/IL4R/ZBTB16/CCL5/ADAM8/RAC2/IL7R/CORO1A/RHOH/RELB/GSN/RASGRP1/LILRB2/ITK/LCK/ICAM1/ADA/LCP1/IRF1/CD8A/GATA3/FCGR2B/TCF7/IL1B/CD2/SMAD3/CCR7/PAK1/XBP1/LILRB4/PTPN6/GPR183/ITGAL/BATF/RAB27A/CD44/PTPRC/CD83/RAB29/PAK2/EGR3/CD3G/CD27/DLG5/CCR2/PTPN22/THY1/BMP4/IGFBP2/ELF4/FZD7/TNFRSF4/LFNG/JMJD6/ZMIZ1/CCR6/NCKAP1L/LAG3/BAD/KDELR1/SATB1/HLA-DMB/CD86/CSK/NLRP3/VAV1/TFRC/TNFSF14/DUSP3/PTPN2/SART1/CCL2/IL2RA/PRDX2/IL15/GLMN/LAT 79 BP GO:0022407 regulation of cell-cell adhesion 71/1096 403/18670 5.165e-17 7.348e-14 4.984e-14 RUNX3/IL4R/SERPINE2/ZBTB16/ADAM19/CCL5/ADAM8/CXCL13/IL7R/CORO1A/VEGFA/ADIPOQ/RASGRP1/IL1RN/ANK3/LILRB2/LCK/ICAM1/ADA/IRF1/GATA3/FCGR2B/IL1B/CCR7/PAK1/XBP1/LILRB4/PTPN6/ASS1/PTAFR/CD44/PTPRC/PDPN/CD83/ITGA4/PAK2/EGR3/CD27/DLG5/SKAP1/CCR2/PTPN22/THY1/BMP4/EFNA5/IGFBP2/MAPK7/ZMIZ1/NCKAP1L/LAG3/BAD/PRKG1/HLA-DMB/CD86/CSK/CXCL12/NLRP3/VAV1/TFRC/TNFSF14/ITGB2/DUSP3/PTPN2/SART1/CCL2/IL2RA/SPINT2/PRDX2/ELANE/IL15/GLMN 71 BP GO:0060326 cell chemotaxis 59/1096 304/18670 2.564e-16 2.432e-13 1.65e-13 GPSM3/CXCR4/PARVA/CCL5/ADAM8/RAC2/RARRES2/CXCL13/CORO1A/CCL13/SEMA5A/TGFB2/VEGFA/IL1RN/CH25H/HBEGF/PTK2B/IL1B/CCL18/CCR7/S1PR1/MAPK3/HSPB1/GPR183/CXCL8/S100A9/CCR5/CXCL1/EGR3/CX3CR1/FGFR1/GAS6/CCR2/CXCL6/CXCR6/CCR6/NCKAP1L/IL17RA/PLA2G7/PF4/CXCL3/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/THBS4/AGTR1/ARHGEF5/VAV1/SAA4/TNFSF14/LGMN/ITGB2/C3AR1/CCL2/PDGFRA/CCL7/FLT1 59 BP GO:1903037 regulation of leukocyte cell-cell adhesion 59/1096 304/18670 2.564e-16 2.432e-13 1.65e-13 RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/RASGRP1/LILRB2/LCK/ICAM1/ADA/IRF1/GATA3/FCGR2B/IL1B/CCR7/PAK1/XBP1/LILRB4/PTPN6/ASS1/PTAFR/CD44/PTPRC/CD83/ITGA4/PAK2/EGR3/CD27/DLG5/SKAP1/CCR2/PTPN22/THY1/BMP4/IGFBP2/ZMIZ1/NCKAP1L/LAG3/BAD/HLA-DMB/CD86/CSK/CXCL12/NLRP3/VAV1/TFRC/TNFSF14/ITGB2/DUSP3/PTPN2/SART1/CCL2/IL2RA/PRDX2/ELANE/IL15/GLMN 59 BP GO:0032496 response to lipopolysaccharide 61/1096 330/18670 8.701e-16 7.074e-13 4.798e-13 TNFAIP3/TNFRSF1B/CCL5/CXCL13/LITAF/AXL/IL1RN/LILRB2/PCK1/ICAM1/SLPI/TIMP4/NFKB2/IL1B/CCR7/CSF2RB/XBP1/MAPK3/GCH1/CXCL8/NFKBIA/ASS1/NFKB1/PTAFR/CCR5/ALPL/LY96/CD14/LDOC1/CXCL1/LILRA2/PLCG2/ATP4B/CX3CR1/SASH1/TFPI/PAF1/PTPN22/CXCL6/F2R/IRF8/CDK4/PF4/CXCL3/TLR2/SERPINE1/CXCL10/CD86/LBP/ABR/NLRP3/PRPF8/PTGER2/CCL2/GNG12/LOXL1/SMAD6/PRDX2/SELP/ELANE/JUN 61 BP GO:0002237 response to molecule of bacterial origin 62/1096 343/18670 1.507e-15 1.072e-12 7.272e-13 TNFAIP3/TNFRSF1B/CCL5/CXCL13/LITAF/AXL/IL1RN/LILRB2/PCK1/ICAM1/SLPI/TIMP4/FCGR2B/NFKB2/IL1B/CCR7/CSF2RB/XBP1/MAPK3/GCH1/CXCL8/NFKBIA/ASS1/NFKB1/PTAFR/CCR5/ALPL/LY96/CD14/LDOC1/CXCL1/LILRA2/PLCG2/ATP4B/CX3CR1/SASH1/TFPI/PAF1/PTPN22/CXCL6/F2R/IRF8/CDK4/PF4/CXCL3/TLR2/SERPINE1/CXCL10/CD86/LBP/ABR/NLRP3/PRPF8/PTGER2/CCL2/GNG12/LOXL1/SMAD6/PRDX2/SELP/ELANE/JUN 62 BP GO:0045785 positive regulation of cell adhesion 68/1096 403/18670 2.297e-15 1.452e-12 9.85e-13 RUNX3/IL4R/ZBTB16/ADAM19/CCL5/ADAM8/CXCL13/ANGPT1/IL7R/ARL2/CORO1A/TGFB2/VEGFA/SPOCK2/ITGAV/RASGRP1/ANK3/LILRB2/LCK/ICAM1/EMP2/ADA/GATA3/PTK2B/DAG1/IL1B/SMAD3/CCR7/PAK1/XBP1/LILRB4/PTPN6/DOCK1/TGM2/PTAFR/CD44/PTPRC/PDPN/CD83/ITGA4/PAK2/EGR3/CD27/SKAP1/CCR2/THY1/ITGA5/IGFBP2/ZMIZ1/NCKAP1L/BAD/NINJ1/HLA-DMB/CD86/CSK/CXCL12/NLRP3/VAV1/TFRC/TNFSF14/SFRP1/ITGB2/SART1/CCL2/IL2RA/ELANE/HYAL1/IL15 68 BP GO:0030595 leukocyte chemotaxis 48/1096 224/18670 3.036e-15 1.674e-12 1.136e-12 GPSM3/CXCR4/CCL5/ADAM8/RAC2/RARRES2/CXCL13/CORO1A/CCL13/TGFB2/VEGFA/IL1RN/CH25H/PTK2B/IL1B/CCL18/CCR7/S1PR1/MAPK3/GPR183/CXCL8/S100A9/CCR5/CXCL1/GAS6/CCR2/CXCL6/CCR6/NCKAP1L/IL17RA/PLA2G7/PF4/CXCL3/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/THBS4/ARHGEF5/VAV1/TNFSF14/LGMN/ITGB2/C3AR1/CCL2/CCL7/FLT1 48 BP GO:0003012 muscle system process 74/1096 465/18670 3.236e-15 1.674e-12 1.136e-12 FOXO1/TNFRSF1B/CXCR4/CALD1/SYNM/TMOD1/CRYAB/TPM2/SSPN/SORBS2/GSN/MYL6B/SGCA/ADA/BIN1/STC1/IL1B/EEF2/SMAD3/SULF1/FXYD1/TPM4/PAK1/DES/ADORA1/NEDD4L/PLN/TNNT1/MYL2/PTAFR/NOL3/MYH11/CD38/RGS2/KCNJ8/CASQ2/TNNC2/MYH2/ASPH/MYL9/MYOM2/MB/MYH7/INPP5F/TNNC1/CAV3/MYL3/PIN1/ACTA2/F2R/ACTA1/TNNI1/ATP2A1/HSPB6/SNTA1/TPM3/MYL1/TTN/IGFBP5/MYBPC2/PRKG1/NEB/CKMT2/KCNB2/PDE9A/HDAC4/CAMTA2/CTTN/PDLIM5/JARID2/MYOM1/ALDOA/CHRM3/IL15 74 BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 47/1096 218/18670 4.629e-15 2.195e-12 1.489e-12 RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/RASGRP1/LILRB2/LCK/ICAM1/ADA/GATA3/IL1B/CCR7/PAK1/XBP1/LILRB4/PTPN6/PTAFR/CD44/PTPRC/CD83/ITGA4/PAK2/EGR3/CD27/SKAP1/CCR2/THY1/IGFBP2/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/CSK/NLRP3/VAV1/TFRC/TNFSF14/ITGB2/SART1/CCL2/IL2RA/ELANE/IL15 47 BP GO:0030098 lymphocyte differentiation 62/1096 353/18670 6.059e-15 2.652e-12 1.799e-12 RUNX3/CD3D/IL4R/ZBTB16/ADAM8/IL7R/RHOH/RELB/AXL/RASGRP1/LILRB2/ITK/LCK/ADA/IRF1/CD8A/GATA3/PTK2B/FCGR2B/TCF7/CD2/CCR7/XBP1/LILRB4/PTPN6/GPR183/BATF/KLF6/PTPRC/CD83/ITGA4/PLCG2/EGR3/CD3G/CD27/GAS6/CCR2/PTPN22/BMP4/FZD7/LFNG/JMJD6/ZMIZ1/CCR6/NCKAP1L/LAG3/BAD/IKZF1/KDELR1/HDAC4/SATB1/CD86/NLRP3/INPP5D/VAV1/SFRP1/PTPN2/SART1/IL2RA/PRDX2/TYRO3/IL15 62 BP GO:0022409 positive regulation of cell-cell adhesion 51/1096 255/18670 7.942e-15 3.228e-12 2.19e-12 RUNX3/IL4R/ZBTB16/ADAM19/CCL5/ADAM8/CXCL13/IL7R/CORO1A/RASGRP1/ANK3/LILRB2/LCK/ICAM1/ADA/GATA3/IL1B/CCR7/PAK1/XBP1/LILRB4/PTPN6/PTAFR/CD44/PTPRC/PDPN/CD83/ITGA4/PAK2/EGR3/CD27/SKAP1/CCR2/THY1/IGFBP2/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/CSK/NLRP3/VAV1/TFRC/TNFSF14/ITGB2/SART1/CCL2/IL2RA/ELANE/IL15 51 BP GO:0030217 T cell differentiation 49/1096 240/18670 1.159e-14 4.399e-12 2.984e-12 RUNX3/CD3D/IL4R/ZBTB16/ADAM8/IL7R/RHOH/RELB/RASGRP1/LILRB2/ITK/LCK/ADA/IRF1/CD8A/GATA3/TCF7/CD2/CCR7/XBP1/LILRB4/GPR183/BATF/PTPRC/CD83/EGR3/CD3G/CD27/CCR2/PTPN22/BMP4/FZD7/LFNG/JMJD6/ZMIZ1/CCR6/NCKAP1L/LAG3/BAD/KDELR1/SATB1/CD86/NLRP3/VAV1/PTPN2/SART1/IL2RA/PRDX2/IL15 49 BP GO:0030049 muscle filament sliding 19/1096 39/18670 7.75e-14 2.594e-11 1.76e-11 TMOD1/TPM2/MYL6B/TPM4/DES/TNNT1/MYL2/TNNC2/MYH2/MYH7/TNNC1/MYL3/ACTA1/TNNI1/TPM3/MYL1/TTN/MYBPC2/NEB 19 BP GO:0033275 actin-myosin filament sliding 19/1096 39/18670 7.75e-14 2.594e-11 1.76e-11 TMOD1/TPM2/MYL6B/TPM4/DES/TNNT1/MYL2/TNNC2/MYH2/MYH7/TNNC1/MYL3/ACTA1/TNNI1/TPM3/MYL1/TTN/MYBPC2/NEB 19 BP GO:0050867 positive regulation of cell activation 64/1096 394/18670 9.665e-14 3.056e-11 2.073e-11 TRBC1/RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/STXBP1/AXL/RASGRP1/LILRB2/LCK/CD226/ADA/GATA3/CD40/IL1B/PLEK/TP53BP1/CD2/CCR7/PAK1/XBP1/LILRB4/PTPN6/GPR183/GAB2/CTSC/PTAFR/CD38/PTPRC/PDPN/LILRA2/CD83/PAK2/EGR3/CD27/GAS6/GATA2/CCR2/THY1/IGFBP2/TNFRSF4/IGKC/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/LBP/CSK/NLRP3/INPP5D/VAV1/TFRC/TNFSF14/IGLC1/ITGB2/SART1/CCL2/IL2RA/SELP/IL15 64 BP GO:0042119 neutrophil activation 74/1096 498/18670 1.225e-13 3.668e-11 2.488e-11 FCN1/TNFRSF1B/CCL5/ADAM8/HUWE1/TNFAIP6/HBB/GSN/ITGAV/LILRB2/SLC2A3/SLPI/SERPINA1/ITGAX/CPNE1/FCGR2B/MLEC/EEF2/LILRA3/CTSD/PTPN6/CXCL8/ITGAL/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PTAFR/PYGB/CHI3L1/CD44/PTPRC/CD14/AMPD3/CXCL1/LILRA2/DNASE1L3/CFP/SLC27A2/CD53/QPCT/CFD/TIMP2/METTL7A/STXBP2/CTSH/CXCL6/SYNGR1/ALDH3B1/STK10/PECAM1/PLAUR/FCGR2A/SELL/GMFG/NCKAP1L/SLC2A5/TLR2/OLR1/LILRB3/ABR/GCA/ITGB2/C3AR1/NRAS/IMPDH1/IMPDH2/ALOX5/PA2G4/VAPA/ELANE/ALDOA/IL15 74 BP GO:0050863 regulation of T cell activation 55/1096 314/18670 2.379e-13 6.77e-11 4.592e-11 RUNX3/TNFRSF1B/IL4R/ZBTB16/CCL5/ADAM8/RAC2/IL7R/CORO1A/GSN/RASGRP1/LILRB2/LCK/ADA/IRF1/GATA3/FCGR2B/IL1B/CD2/CCR7/PAK1/XBP1/LILRB4/PTPN6/PTPRC/CD83/PAK2/EGR3/CD27/DLG5/CCR2/PTPN22/THY1/BMP4/IGFBP2/ZMIZ1/NCKAP1L/LAG3/BAD/HLA-DMB/CD86/CSK/NLRP3/VAV1/TFRC/TNFSF14/DUSP3/PTPN2/SART1/CCL2/IL2RA/PRDX2/IL15/GLMN/LAT 55 BP GO:0050920 regulation of chemotaxis 44/1096 217/18670 3.417e-13 9.26e-11 6.28e-11 GPSM3/CXCR4/CCL5/RAC2/RARRES2/CXCL13/SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/PTK2B/SMAD3/CCR7/S1PR1/MAPK3/HSPB1/GPR183/CXCL8/FGFR1/GAS6/CCR2/SEMA3C/SEMA4F/NTF3/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/THBS4/TNFSF14/LGMN/DUSP3/C3AR1/PTPN2/ANGPT2/CCL2/PDGFRA/ELANE/CCL7 44 BP GO:0030048 actin filament-based movement 34/1096 138/18670 5.107e-13 1.293e-10 8.772e-11 PARVA/TMOD1/TPM2/MYL6B/FNBP1L/EMP2/BIN1/STC1/TPM4/DES/ADORA1/NEDD4L/PLN/TNNT1/MYL2/MYH10/KCNJ8/PDPN/TNNC2/MYH2/MYH7/TNNC1/CAV3/MYL3/ACTA1/TNNI1/ATP2A1/SNTA1/TPM3/MYL1/MYO1B/TTN/MYBPC2/NEB 34 BP GO:0070252 actin-mediated cell contraction 31/1096 116/18670 5.227e-13 1.293e-10 8.772e-11 PARVA/TMOD1/TPM2/MYL6B/EMP2/BIN1/STC1/TPM4/DES/ADORA1/NEDD4L/PLN/TNNT1/MYL2/KCNJ8/PDPN/TNNC2/MYH2/MYH7/TNNC1/CAV3/MYL3/ACTA1/TNNI1/ATP2A1/SNTA1/TPM3/MYL1/TTN/MYBPC2/NEB 31 BP GO:0071219 cellular response to molecule of bacterial origin 43/1096 212/18670 6.275e-13 1.488e-10 1.009e-10 TNFAIP3/TNFRSF1B/CCL5/CXCL13/LITAF/AXL/IL1RN/LILRB2/ICAM1/FCGR2B/IL1B/XBP1/MAPK3/CXCL8/NFKBIA/ASS1/NFKB1/PTAFR/CCR5/LY96/CD14/LDOC1/CXCL1/LILRA2/CX3CR1/SASH1/TFPI/PAF1/PTPN22/CXCL6/IRF8/CDK4/PF4/CXCL3/TLR2/SERPINE1/CXCL10/CD86/LBP/NLRP3/PRPF8/CCL2/PRDX2 43 BP GO:0002685 regulation of leukocyte migration 41/1096 196/18670 7.484e-13 1.704e-10 1.156e-10 PLCB1/GPSM3/CCL5/ADAM8/RAC2/RARRES2/CXCL13/VEGFA/CD200/ICAM1/ADA/PTK2B/CCR7/MAPK3/ADORA1/IL27RA/CXCL8/PTAFR/ITGA4/CX3CR1/GAS6/CCR2/THY1/STK10/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/ABR/THBS4/TNFSF14/LGMN/C3AR1/CCL2/SELP/ELANE/CCL7 41 BP GO:0051249 regulation of lymphocyte activation 71/1096 485/18670 8.191e-13 1.727e-10 1.171e-10 TRBC1/RUNX3/TNFAIP3/TNFRSF1B/IL4R/ZBTB16/CCL5/ADAM8/RAC2/IL7R/CORO1A/GSN/AXL/RASGRP1/LILRB2/LCK/ADA/IRF1/GATA3/CD40/FCGR2B/IL1B/TP53BP1/CD2/CCR7/PAK1/XBP1/LILRB4/PTPN6/GPR183/IL27RA/CD38/PTPRC/CD83/PAK2/EGR3/CD27/DLG5/GAS6/CCR2/PTPN22/THY1/BMP4/IGFBP2/PARP3/TNFRSF4/IGKC/ZMIZ1/NCKAP1L/LAG3/BAD/HLA-DMB/CD86/CSK/NLRP3/INPP5D/VAV1/TFRC/TNFSF14/IGLC1/SFRP1/DUSP3/PTPN2/SART1/CCL2/IL2RA/PRDX2/TYRO3/IL15/GLMN/LAT 71 BP GO:0071222 cellular response to lipopolysaccharide 42/1096 205/18670 8.193e-13 1.727e-10 1.171e-10 TNFAIP3/TNFRSF1B/CCL5/CXCL13/LITAF/AXL/IL1RN/LILRB2/ICAM1/IL1B/XBP1/MAPK3/CXCL8/NFKBIA/ASS1/NFKB1/PTAFR/CCR5/LY96/CD14/LDOC1/CXCL1/LILRA2/CX3CR1/SASH1/TFPI/PAF1/PTPN22/CXCL6/IRF8/CDK4/PF4/CXCL3/TLR2/SERPINE1/CXCL10/CD86/LBP/NLRP3/PRPF8/CCL2/PRDX2 42 BP GO:0071216 cellular response to biotic stimulus 45/1096 236/18670 1.781e-12 3.554e-10 2.411e-10 TNFAIP3/TNFRSF1B/CCL5/CXCL13/LITAF/AXL/IL1RN/LILRB2/ICAM1/FCGR2B/IL1B/XBP1/MAPK3/CXCL8/NFKBIA/ASS1/NFKB1/PTAFR/CCR5/HSPA5/LY96/CD14/LDOC1/CXCL1/LILRA2/CX3CR1/SASH1/TFPI/PAF1/PTPN22/CXCL6/IRF8/CDK4/PF4/CXCL3/TLR2/SERPINE1/CXCL10/CD86/LBP/NLRP3/PRPF8/CCL2/WFS1/PRDX2 45 BP GO:0006909 phagocytosis 59/1096 369/18670 1.811e-12 3.554e-10 2.411e-10 CD247/TRBC1/FCN1/ARHGAP12/IL15RA/GULP1/IL2RG/CORO1A/P2RY6/IL2RB/GSN/ITGAV/ADIPOQ/AXL/FCGR2B/IL1B/SLAMF1/PAK1/MAPK3/ADORA1/DOCK1/ITGAL/TGM2/RAB27A/ANXA11/PTPRC/CD14/MYH2/MYD88/TM9SF4/PLCG2/CD3G/GAS6/GATA2/RAPGEF1/IRF8/PECAM1/FCGR2A/IGKC/CEACAM4/JMJD6/NCKAP1/NCKAP1L/TLR2/RHOBTB1/IGLV6-57/ARPC3/LBP/CSK/ABR/VAV1/IGLC1/ITGB2/NCF2/CCL2/TYRO3/ELANE/CYFIP2/IL15 59 BP GO:0097529 myeloid leukocyte migration 42/1096 210/18670 1.904e-12 3.608e-10 2.447e-10 PLCB1/CCL5/ADAM8/RAC2/RARRES2/CXCL13/CCL13/TGFB2/VEGFA/CD200/IL1RN/PTK2B/IL1B/CCL18/CCR7/MAPK3/CXCL8/S100A9/CXCL1/CX3CR1/CCR2/CXCL6/PECAM1/NCKAP1L/IL17RA/PLA2G7/PF4/CXCL3/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/THBS4/ARHGEF5/VAV1/LGMN/ITGB2/C3AR1/CCL2/CCL7/FLT1 42 BP GO:0006936 muscle contraction 58/1096 360/18670 2.028e-12 3.608e-10 2.447e-10 CXCR4/CALD1/SYNM/TMOD1/CRYAB/TPM2/SSPN/MYL6B/SGCA/ADA/BIN1/STC1/EEF2/SULF1/FXYD1/TPM4/DES/ADORA1/NEDD4L/PLN/TNNT1/MYL2/PTAFR/MYH11/CD38/RGS2/KCNJ8/CASQ2/TNNC2/MYH2/ASPH/MYL9/MYOM2/MB/MYH7/TNNC1/CAV3/MYL3/ACTA2/F2R/ACTA1/TNNI1/ATP2A1/HSPB6/SNTA1/TPM3/MYL1/TTN/MYBPC2/PRKG1/NEB/CKMT2/KCNB2/HDAC4/CTTN/MYOM1/ALDOA/CHRM3 58 BP GO:0002696 positive regulation of leukocyte activation 60/1096 380/18670 2.029e-12 3.608e-10 2.447e-10 TRBC1/RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/STXBP1/AXL/RASGRP1/LILRB2/LCK/CD226/ADA/GATA3/CD40/IL1B/TP53BP1/CD2/CCR7/PAK1/XBP1/LILRB4/PTPN6/GPR183/GAB2/CTSC/PTAFR/CD38/PTPRC/CD83/PAK2/EGR3/CD27/GAS6/GATA2/CCR2/THY1/IGFBP2/TNFRSF4/IGKC/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/LBP/CSK/NLRP3/INPP5D/VAV1/TFRC/TNFSF14/IGLC1/ITGB2/SART1/CCL2/IL2RA/IL15 60 BP GO:0060537 muscle tissue development 62/1096 408/18670 4.743e-12 8.18e-10 5.548e-10 TGFBR3/EGR2/TGFB2/VEGFA/SORBS2/CDON/MYL6B/HLF/SIX1/SVIL/FLNB/NUPR1/EEF2/SMAD3/PAK1/S1PR1/RBP4/BTG2/PLN/SIK1/PITX1/MYL2/MYH11/RGS2/MYH10/SRPK3/CSRP1/KCNAB1/SMAD1/MYOM2/FGFR1/MYH7/TNNC1/CAV3/SEMA3C/MYL3/PIN1/ACTA1/BMP4/PIM1/TNNI1/GPX1/FZD7/CCNB1/TTN/IGFBP5/MYBPC2/UBE4B/NEB/HDAC4/BMPR1A/PDLIM5/JARID2/TWIST1/MAFF/FOXC1/CBY1/PDGFRA/NPRL3/COL3A1/MYOM1/RXRA 62 BP GO:0050921 positive regulation of chemotaxis 32/1096 135/18670 7.552e-12 1.264e-09 8.573e-10 GPSM3/CXCR4/CCL5/RAC2/RARRES2/CXCL13/SEMA5A/VEGFA/NTRK3/PTK2B/SMAD3/CCR7/S1PR1/MAPK3/HSPB1/CXCL8/FGFR1/GAS6/CCR2/NTF3/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/LBP/CXCL12/THBS4/TNFSF14/LGMN/C3AR1/CCL7 32 BP GO:0002687 positive regulation of leukocyte migration 31/1096 128/18670 8.793e-12 1.377e-09 9.337e-10 GPSM3/CCL5/ADAM8/RAC2/RARRES2/CXCL13/VEGFA/ICAM1/PTK2B/CCR7/MAPK3/CXCL8/PTAFR/ITGA4/GAS6/CCR2/THY1/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/LBP/CXCL12/THBS4/TNFSF14/LGMN/C3AR1/SELP/ELANE/CCL7 31 BP GO:0050870 positive regulation of T cell activation 40/1096 202/18670 8.909e-12 1.377e-09 9.337e-10 RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/RASGRP1/LILRB2/LCK/ADA/GATA3/IL1B/CCR7/PAK1/XBP1/LILRB4/PTPN6/PTPRC/CD83/PAK2/EGR3/CD27/CCR2/THY1/IGFBP2/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/CSK/NLRP3/VAV1/TFRC/TNFSF14/SART1/CCL2/IL2RA/IL15 40 BP GO:0002283 neutrophil activation involved in immune response 69/1096 488/18670 8.95e-12 1.377e-09 9.337e-10 FCN1/TNFRSF1B/ADAM8/HUWE1/TNFAIP6/HBB/GSN/ITGAV/LILRB2/SLC2A3/SLPI/SERPINA1/ITGAX/CPNE1/MLEC/EEF2/LILRA3/CTSD/PTPN6/ITGAL/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PTAFR/PYGB/CHI3L1/CD44/PTPRC/CD14/AMPD3/CXCL1/LILRA2/DNASE1L3/CFP/SLC27A2/CD53/QPCT/CFD/TIMP2/METTL7A/STXBP2/CTSH/SYNGR1/ALDH3B1/STK10/PECAM1/PLAUR/FCGR2A/SELL/GMFG/NCKAP1L/SLC2A5/TLR2/OLR1/LILRB3/ABR/GCA/ITGB2/C3AR1/NRAS/IMPDH1/IMPDH2/ALOX5/PA2G4/VAPA/ELANE/ALDOA 69 BP GO:0045621 positive regulation of lymphocyte differentiation 26/1096 94/18670 1.669e-11 2.5e-09 1.696e-09 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/AXL/RASGRP1/LILRB2/ADA/GATA3/XBP1/LILRB4/PTPRC/CD83/EGR3/CD27/GAS6/ZMIZ1/NCKAP1L/BAD/CD86/NLRP3/INPP5D/SART1/IL2RA/IL15 26 BP GO:0007517 muscle organ development 61/1096 410/18670 1.755e-11 2.561e-09 1.737e-09 TGFBR3/EGR2/CRYAB/TGFB2/CDON/MYL6B/HLF/SIX1/SVIL/SGCA/FLNB/HBEGF/NUPR1/EEF2/SMAD3/PAK1/S1PR1/RBP4/XBP1/BTG2/FZD2/ID3/PITX1/MYL2/ASS1/RGS2/SRPK3/KCNAB1/EGR3/MYOM2/FGFR1/MYH7/TNNC1/CAV3/MYL3/PIN1/TAGLN/ACTA1/BMP4/PIM1/TNNI1/GPX1/FZD7/CCNB1/BASP1/TTN/MYBPC2/UBE4B/NEB/CXCL10/HDAC4/BMPR1A/JARID2/TWIST1/MAFF/FOXC1/FHL1/COL3A1/MYOM1/RXRA/TCF15 61 BP GO:0014706 striated muscle tissue development 59/1096 390/18670 1.898e-11 2.701e-09 1.832e-09 TGFBR3/EGR2/TGFB2/VEGFA/SORBS2/CDON/MYL6B/HLF/SIX1/SVIL/FLNB/NUPR1/EEF2/SMAD3/PAK1/S1PR1/RBP4/BTG2/PLN/SIK1/PITX1/MYL2/MYH11/RGS2/MYH10/SRPK3/KCNAB1/SMAD1/MYOM2/FGFR1/MYH7/TNNC1/CAV3/SEMA3C/MYL3/PIN1/ACTA1/BMP4/PIM1/TNNI1/GPX1/FZD7/CCNB1/TTN/MYBPC2/UBE4B/NEB/HDAC4/BMPR1A/PDLIM5/JARID2/TWIST1/MAFF/FOXC1/CBY1/PDGFRA/NPRL3/MYOM1/RXRA 59 BP GO:1902105 regulation of leukocyte differentiation 47/1096 272/18670 2.181e-11 3.027e-09 2.053e-09 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/ADIPOQ/AXL/RASGRP1/LILRB2/ADA/IRF1/GATA3/TCTA/FCGR2B/CD2/XBP1/LILRB4/PTPN6/PTPRC/CD83/EGR3/CD27/HCLS1/GAS6/GATA2/CCR2/BMP4/ZMIZ1/NCKAP1L/LAG3/PF4/BAD/CTNNBIP1/LILRB3/IRF7/CD86/NLRP3/APCS/INPP5D/SFRP1/PTPN2/SART1/IL2RA/CUL4A/PRDX2/IL15/JUN 47 BP GO:0002446 neutrophil mediated immunity 69/1096 499/18670 2.507e-11 3.397e-09 2.304e-09 FCN1/TNFRSF1B/ADAM8/HUWE1/TNFAIP6/HBB/GSN/ITGAV/LILRB2/SLC2A3/SLPI/SERPINA1/ITGAX/CPNE1/MLEC/EEF2/LILRA3/CTSD/PTPN6/ITGAL/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PTAFR/PYGB/CHI3L1/CD44/PTPRC/CD14/AMPD3/CXCL1/DNASE1L3/CFP/SLC27A2/CD53/QPCT/CFD/TIMP2/METTL7A/STXBP2/CTSH/CXCL6/SYNGR1/ALDH3B1/STK10/PECAM1/PLAUR/FCGR2A/SELL/GMFG/NCKAP1L/SLC2A5/TLR2/OLR1/LILRB3/ABR/GCA/ITGB2/C3AR1/NRAS/IMPDH1/IMPDH2/ALOX5/PA2G4/VAPA/ELANE/ALDOA 69 BP GO:0032103 positive regulation of response to external stimulus 52/1096 323/18670 2.942e-11 3.894e-09 2.641e-09 GPSM3/CXCR4/LPL/CCL5/ADAM8/RAC2/RARRES2/CXCL13/SEMA5A/FABP4/VEGFA/EGFR/NTRK3/PTK2B/NUPR1/IL1B/CCL18/SMAD3/CCR7/S1PR1/MAPK3/HSPB1/CXCL8/TGM2/NFKBIA/S100A9/CTSC/LY96/MYD88/FGFR1/GAS6/SASH1/CCR2/UNC13B/NTF3/CCR6/NCKAP1L/IL17RA/PLA2G7/TLR2/SERPINE1/CXCL10/MAPK13/LBP/CXCL12/THBS4/AGTR1/TNFSF14/LGMN/C3AR1/CCL7/IL15 52 BP GO:0045619 regulation of lymphocyte differentiation 35/1096 169/18670 4.805e-11 6.214e-09 4.215e-09 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/AXL/RASGRP1/LILRB2/ADA/IRF1/GATA3/CD2/XBP1/LILRB4/PTPN6/PTPRC/CD83/EGR3/CD27/GAS6/CCR2/BMP4/ZMIZ1/NCKAP1L/LAG3/BAD/CD86/NLRP3/INPP5D/SFRP1/PTPN2/SART1/IL2RA/PRDX2/IL15 35 BP GO:0043312 neutrophil degranulation 67/1096 485/18670 5.127e-11 6.484e-09 4.398e-09 FCN1/TNFRSF1B/ADAM8/HUWE1/TNFAIP6/HBB/GSN/ITGAV/LILRB2/SLC2A3/SLPI/SERPINA1/ITGAX/CPNE1/MLEC/EEF2/LILRA3/CTSD/PTPN6/ITGAL/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PTAFR/PYGB/CHI3L1/CD44/PTPRC/CD14/AMPD3/CXCL1/CFP/SLC27A2/CD53/QPCT/CFD/TIMP2/METTL7A/STXBP2/CTSH/SYNGR1/ALDH3B1/STK10/PECAM1/PLAUR/FCGR2A/SELL/GMFG/NCKAP1L/SLC2A5/TLR2/OLR1/LILRB3/ABR/GCA/ITGB2/C3AR1/NRAS/IMPDH1/IMPDH2/ALOX5/PA2G4/VAPA/ELANE/ALDOA 67 BP GO:0043062 extracellular structure organization 61/1096 422/18670 5.931e-11 7.337e-09 4.977e-09 SPP1/TNFRSF1B/DDR2/LPL/ADAM19/ADAM8/ITGB7/LOXL2/TGFB2/SPOCK2/ITGAV/PXDN/ICAM1/MFAP4/LCP1/ITGAX/DAG1/NFKB2/POSTN/SMAD3/SULF1/SDC1/KAZALD1/ITGAL/FBLN5/MYH11/CD44/LIPC/ADAMTS2/PDPN/ADAMTS3/CTSL/ABCG1/ITGA4/COL1A1/GAS6/TIMP2/APOC1/ITGA5/PECAM1/EFEMP2/PLA2G7/HTRA1/APOE/SERPINE1/ADAM12/CAPNS1/LAMB2/AGTR1/FOXC1/ITGB2/SPINT2/PDGFRA/LOXL1/COL3A1/MMP15/ELANE/COL4A1/HYAL1/TCF15/ADAMTSL2 61 BP GO:0002690 positive regulation of leukocyte chemotaxis 24/1096 87/18670 1.065e-10 1.289e-08 8.746e-09 GPSM3/CCL5/RAC2/RARRES2/CXCL13/VEGFA/PTK2B/CCR7/MAPK3/CXCL8/GAS6/CCR2/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/LBP/CXCL12/THBS4/TNFSF14/LGMN/C3AR1/CCL7 24 BP GO:1903708 positive regulation of hemopoiesis 36/1096 185/18670 1.634e-10 1.937e-08 1.314e-08 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/AXL/RASGRP1/LILRB2/ADA/GATA3/XBP1/LILRB4/PTPRC/CD83/EGR3/CD27/HCLS1/GAS6/GATA2/HOXA5/HIF1A/ZMIZ1/NCKAP1L/PF4/BAD/STAT1/CTNNBIP1/CD86/NLRP3/INPP5D/FOXC1/SART1/IL2RA/TRIM58/IL15/JUN 36 BP GO:0051251 positive regulation of lymphocyte activation 51/1096 334/18670 3.208e-10 3.726e-08 2.527e-08 TRBC1/RUNX3/IL4R/ZBTB16/CCL5/ADAM8/IL7R/CORO1A/AXL/RASGRP1/LILRB2/LCK/ADA/GATA3/CD40/IL1B/TP53BP1/CCR7/PAK1/XBP1/LILRB4/PTPN6/GPR183/CD38/PTPRC/CD83/PAK2/EGR3/CD27/GAS6/CCR2/THY1/IGFBP2/TNFRSF4/IGKC/ZMIZ1/NCKAP1L/BAD/HLA-DMB/CD86/CSK/NLRP3/INPP5D/VAV1/TFRC/TNFSF14/IGLC1/SART1/CCL2/IL2RA/IL15 51 BP GO:0002683 negative regulation of immune system process 63/1096 463/18670 3.672e-10 4.18e-08 2.835e-08 RUNX3/PLCB1/TNFAIP3/IL4R/ZBTB16/ANGPT1/IL7R/TGFB2/CD200/ADIPOQ/AXL/LILRB2/ADA/IRF1/PTK2B/TCTA/FCGR2B/ADORA1/LILRB4/PTPN6/IL27RA/NFKBIA/PTPRC/LY96/MFHAS1/CD14/LILRA2/CST7/DLG5/GATA2/PAF1/CCR2/PTPN22/HOXA5/THY1/NMI/BMP4/GPX1/PARP3/PCBP2/LAG3/PF4/GRAMD4/HLA-DOB/HTRA1/GBP1/LILRB3/CD86/CXCL12/ABR/APCS/INPP5D/LPXN/SFRP1/DUSP3/PTPN2/CCL2/IL2RA/CUL4A/COL3A1/PRDX2/TYRO3/GLMN 63 BP GO:0045580 regulation of T cell differentiation 30/1096 139/18670 4.014e-10 4.393e-08 2.98e-08 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/RASGRP1/LILRB2/ADA/IRF1/GATA3/CD2/XBP1/LILRB4/PTPRC/CD83/EGR3/CD27/CCR2/BMP4/ZMIZ1/NCKAP1L/LAG3/BAD/CD86/NLRP3/PTPN2/SART1/IL2RA/PRDX2/IL15 30 BP GO:0001819 positive regulation of cytokine production 63/1096 464/18670 4.014e-10 4.393e-08 2.98e-08 PLCB1/FCN1/IL4R/GPSM3/ZBTB20/LPL/ADAM8/CD200/ADIPOQ/RASGRP1/IL1RN/LILRB2/CD226/IRF1/GATA3/AIM2/BIRC3/CD40/NFKB2/IL1B/POSTN/CD2/SMAD3/SULF1/CCR7/XBP1/MAPK3/HSPB1/IL27RA/NFKB1/PTAFR/SPTBN1/PTPRC/LY96/CRTAM/CD14/LILRA2/MYD88/CD83/PLCG2/CCR2/PTPN22/HIF1A/F2R/IRF8/POLR2E/IL17RA/PF4/TLR2/STAT1/SERPINE1/MAPK13/IRF7/CD86/LBP/TWIST1/NLRP3/AGPAT1/C3AR1/POLR1C/ELANE/IL15/GLMN 63 BP GO:0045444 fat cell differentiation 39/1096 223/18670 7.722e-10 8.285e-08 5.619e-08 FOXO1/PLCB1/ALDH6A1/ZBTB16/GRK5/LPL/FTO/RARRES2/EGR2/SH2B2/WIF1/WWTR1/FABP4/ADIPOQ/ADIRF/ENPP1/GATA3/TCF7L2/SMAD3/XBP1/CCND1/RGS2/TRIB2/ARL4A/MB/GATA2/ID4/FBXO9/GPX1/LRP5/LMO3/GDF10/CARM1/SFRP1/CBY1/BNIP3/SMAD6/INHBB/ATF5 39 BP GO:2001233 regulation of apoptotic signaling pathway 57/1096 406/18670 7.861e-10 8.285e-08 5.619e-08 TNFAIP3/GZMB/GSN/ITGAV/TNFRSF10B/LCK/ICAM1/PCGF2/NUPR1/TCF7L2/IL1B/SMAD3/BCL2L2/XBP1/HSPB1/S100A9/CTSC/NOL3/TNFSF10/CD44/PTPRC/NACC2/TRAF1/MAGED1/PAK2/TRAP1/CX3CR1/AR/FGFR1/CTSH/HIF1A/PINK1/G0S2/BMP4/GPX1/PLAUR/MAPK7/HDAC1/ZNF205/TIMP3/PF4/BAD/BCL2A1/SERPINE1/MLLT11/CTTN/CXCL12/TFAP4/SFRP1/PTPN2/BNIP3/WFS1/PRDX2/PPP3CC/INHBB/HERPUD1/PTTG1IP 57 BP GO:0070098 chemokine-mediated signaling pathway 23/1096 88/18670 8.427e-10 8.72e-08 5.914e-08 CXCR4/CCL5/CXCL13/CCL13/PTK2B/CCL18/CCR7/CXCL8/CCR5/CXCL1/CX3CR1/CCR2/CXCL6/HIF1A/CXCR6/CCR6/PF4/CXCL3/CXCL10/CXCL12/FOXC1/CCL2/CCL7 23 BP GO:0031589 cell-substrate adhesion 52/1096 354/18670 8.82e-10 8.963e-08 6.08e-08 DDR2/PARVA/RAC2/ITGB7/ANGPT1/ARL2/CORO1A/VEGFA/SPOCK2/ITGAV/EPHA3/SEMA3E/AXL/EMP2/PTK2B/DAG1/TMEM8B/ACTN1/POSTN/SMAD3/CCR7/DOCK1/ITGAL/FBLN5/CD44/PDPN/ITGA4/ID1/COL1A1/GAS6/ITGBL1/SKAP1/KANK1/THY1/DLC1/ITGA5/EFNA5/PECAM1/FZD7/GBP1/NINJ1/SERPINE1/SNED1/CTTN/LAMB2/SFRP1/ITGB2/DUSP3/ANGPT2/COL3A1/SMAD6/TYRO3 52 BP GO:0034113 heterotypic cell-cell adhesion 19/1096 61/18670 9.692e-10 9.51e-08 6.45e-08 PARVA/ITGB7/ITGAV/CD200/ADIPOQ/IL1RN/LILRB2/LCK/ITGAX/IL1B/CD2/CD44/PTPRC/ITGA4/SKAP1/THY1/ITGA5/MAPK7/ITGB2 19 BP GO:0045123 cellular extravasation 19/1096 61/18670 9.692e-10 9.51e-08 6.45e-08 PLCB1/ADAM8/ITGB7/ICAM1/SELPLG/IL27RA/PTAFR/ITGA4/CX3CR1/CCR2/THY1/PECAM1/SELL/CXCL12/ABR/ITGB2/CCL2/SELP/ELANE 19 BP GO:1902107 positive regulation of leukocyte differentiation 30/1096 144/18670 9.901e-10 9.55e-08 6.477e-08 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/AXL/RASGRP1/LILRB2/ADA/GATA3/XBP1/LILRB4/PTPRC/CD83/EGR3/CD27/HCLS1/GAS6/ZMIZ1/NCKAP1L/PF4/BAD/CTNNBIP1/CD86/NLRP3/INPP5D/SART1/IL2RA/IL15/JUN 30 BP GO:0030168 platelet activation 31/1096 153/18670 1.077e-09 1.021e-07 6.926e-08 SERPINE2/HBB/STXBP1/AXL/LCK/PRKCB/CD40/PLEK/MAPK3/HSPB1/PTPN6/GNA11/PDPN/CSRP1/LCP2/PLSCR1/MYL9/PLCG2/COL1A1/GAS6/F2R/PF4/F8/PRKG1/APOE/PRKCH/VAV1/PDGFRA/COL3A1/TYRO3/SELP 31 BP GO:0046677 response to antibiotic 49/1096 327/18670 1.371e-09 1.279e-07 8.678e-08 FOXO1/TNFAIP3/CRYAB/HBB/GSN/ADIPOQ/AXL/AOC3/ICAM1/ADA/GATA3/NTRK3/PCGF2/PTK2B/EEF2/DAXX/SDC1/RBP4/ID3/GOT2/CCND1/ALPL/RGS2/HSPA5/CD14/ID1/TRAP1/CD27/COL1A1/OXCT1/MB/ADCY6/CDO1/PINK1/EFNA5/GPX1/NQO1/MAPK7/AQP1/BAD/USP46/STAT1/CA3/MAPK13/BNIP3/CCL7/HYAL1/JUN/ADCY1 49 BP GO:0045582 positive regulation of T cell differentiation 22/1096 83/18670 1.465e-09 1.345e-07 9.121e-08 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/RASGRP1/LILRB2/ADA/GATA3/XBP1/LILRB4/PTPRC/CD83/EGR3/CD27/ZMIZ1/NCKAP1L/BAD/CD86/NLRP3/SART1/IL2RA 22 BP GO:0002697 regulation of immune effector process 61/1096 458/18670 1.641e-09 1.482e-07 1.005e-07 TNFAIP3/TNFRSF1B/IL4R/RAC2/ANGPT1/IL7R/TGFB2/STXBP1/CFB/RASGRP1/CD226/GATA3/AIM2/BIRC3/SH2D1A/CD40/FCGR2B/IL1B/TP53BP1/RBP4/XBP1/MAPK3/TRIL/PTPN6/IL27RA/GAB2/PTAFR/PTPRC/CRTAM/DNASE1L3/CFP/GATA2/STXBP2/CCR2/CXCL6/RAPGEF1/PARP3/TNFRSF4/IGKC/PCBP2/CFI/PHB/LAG3/HTRA1/STAT1/IGLV6-57/HLA-DMB/C6/CD86/LBP/ABR/NLRP3/VAV1/TRAF3/TFRC/IGLC1/C7/ITGB2/C3AR1/IL2RA/IL15 61 BP GO:0002688 regulation of leukocyte chemotaxis 26/1096 114/18670 1.682e-09 1.495e-07 1.014e-07 GPSM3/CCL5/RAC2/RARRES2/CXCL13/VEGFA/PTK2B/CCR7/MAPK3/CXCL8/GAS6/CCR2/CCR6/NCKAP1L/PLA2G7/SERPINE1/CXCL10/MTUS1/LBP/CXCL12/THBS4/TNFSF14/LGMN/C3AR1/CCL2/CCL7 26 BP GO:0045765 regulation of angiogenesis 54/1096 383/18670 1.89e-09 1.655e-07 1.122e-07 TNFAIP3/CXCR4/CXCL13/MECP2/SEMA5A/TGFB2/VEGFA/SEMA3E/EMP2/AKT3/PRKCB/PTK2B/ITGAX/CD40/THBS2/IL1B/SULF1/HK2/XBP1/HSPB1/CXCL8/CHI3L1/CDH5/SMAD1/ID1/CX3CR1/SASH1/PLK2/GATA2/CTSH/CCR2/HOXA5/HIF1A/ITGA5/HSPB6/MAPK7/AQP1/PF4/STAT1/SERPINE1/ADAM12/CXCL10/C6/TWIST1/THBS4/AGTR1/FOXC1/SFRP1/ITGB2/C3AR1/ANGPT2/HYAL1/FLT1/AMOT 54 BP GO:0071621 granulocyte chemotaxis 27/1096 123/18670 2.021e-09 1.742e-07 1.182e-07 CCL5/RAC2/RARRES2/CXCL13/CCL13/TGFB2/IL1RN/IL1B/CCL18/CCR7/MAPK3/CXCL8/S100A9/CXCL1/CXCL6/NCKAP1L/IL17RA/PF4/CXCL3/CXCL10/LBP/THBS4/VAV1/ITGB2/C3AR1/CCL2/CCL7 27 BP GO:0050727 regulation of inflammatory response 63/1096 485/18670 2.412e-09 2.049e-07 1.389e-07 TNFAIP3/TNFRSF1B/GPSM3/LPL/CCL5/ADAM8/TNFAIP6/FABP4/CD200/EGFR/ADIPOQ/CFB/ADA/GATA3/BIRC3/FCGR2B/NUPR1/IL1B/CCL18/GPX4/SMAD3/CCR7/ADORA1/TGM2/NFKBIA/S100A9/NFKB1/CTSC/PTPRC/CDH5/MFHAS1/MYD88/DNASE1L3/CFP/CST7/CCR2/GPX1/MAPK7/IGKC/NFE2L1/CFI/PHB/IL17RA/PLA2G7/TLR2/APOE/SERPINE1/IGLV6-57/MAPK13/C6/LBP/ABR/NLRP3/AGTR1/APCS/IGLC1/C7/C3AR1/PTPN2/IL2RA/TYRO3/ELANE/IL15 63 BP GO:0097530 granulocyte migration 29/1096 141/18670 2.57e-09 2.151e-07 1.459e-07 CCL5/ADAM8/RAC2/RARRES2/CXCL13/CCL13/TGFB2/IL1RN/IL1B/CCL18/CCR7/MAPK3/CXCL8/S100A9/CXCL1/CXCL6/PECAM1/NCKAP1L/IL17RA/PF4/CXCL3/CXCL10/LBP/THBS4/VAV1/ITGB2/C3AR1/CCL2/CCL7 29 BP GO:0048738 cardiac muscle tissue development 39/1096 233/18670 2.841e-09 2.343e-07 1.589e-07 TGFBR3/TGFB2/VEGFA/SORBS2/PAK1/S1PR1/RBP4/PLN/SIK1/MYL2/MYH11/RGS2/MYH10/SMAD1/MYOM2/FGFR1/MYH7/TNNC1/CAV3/MYL3/PIN1/BMP4/PIM1/TNNI1/FZD7/CCNB1/TTN/MYBPC2/UBE4B/NEB/BMPR1A/PDLIM5/JARID2/FOXC1/CBY1/PDGFRA/NPRL3/MYOM1/RXRA 39 BP GO:0007015 actin filament organization 55/1096 400/18670 3.35e-09 2.724e-07 1.847e-07 ARHGAP12/RAC2/TMOD1/CORO1A/SEMA5A/RHOH/TPM2/SORBS2/GSN/ICAM1/EMP2/LCP1/BIN1/ARHGEF10/PTK2B/RHOBTB3/ACTN1/PLEK/SMAD3/CCR7/TPM4/PAK1/S1PR1/SPTBN1/FAM171A1/ID1/HCLS1/MYOM2/CAPG/TNFAIP1/KANK1/CAV3/ACTA1/DLC1/GMFG/TPM3/MYO1B/NCKAP1/TTN/NCKAP1L/MYBPC2/HIP1/RHOBTB1/NEB/CTTN/ARPC3/CXCL12/ARHGEF5/SFRP1/PSTPIP1/COBL/TENM1/PFN2/MYOM1/ALDOA 55 BP GO:0030198 extracellular matrix organization 52/1096 368/18670 3.495e-09 2.801e-07 1.9e-07 SPP1/TNFRSF1B/DDR2/ADAM19/ADAM8/ITGB7/LOXL2/TGFB2/SPOCK2/ITGAV/PXDN/ICAM1/MFAP4/LCP1/ITGAX/DAG1/NFKB2/POSTN/SMAD3/SULF1/KAZALD1/ITGAL/FBLN5/MYH11/CD44/ADAMTS2/PDPN/ADAMTS3/CTSL/ITGA4/COL1A1/GAS6/TIMP2/ITGA5/PECAM1/EFEMP2/HTRA1/SERPINE1/ADAM12/CAPNS1/LAMB2/FOXC1/ITGB2/SPINT2/PDGFRA/LOXL1/COL3A1/MMP15/ELANE/COL4A1/TCF15/ADAMTSL2 52 BP GO:1990266 neutrophil migration 26/1096 118/18670 3.682e-09 2.911e-07 1.974e-07 CCL5/ADAM8/RAC2/CXCL13/CCL13/TGFB2/IL1RN/IL1B/CCL18/CCR7/CXCL8/S100A9/CXCL1/CXCL6/PECAM1/NCKAP1L/PF4/CXCL3/CXCL10/LBP/THBS4/VAV1/ITGB2/C3AR1/CCL2/CCL7 26 BP GO:0048872 homeostasis of number of cells 40/1096 246/18670 4.227e-09 3.296e-07 2.235e-07 TNFAIP3/TGFBR3/SH2B2/IL7R/CORO1A/VEGFA/AXL/ADA/THRA/AKT3/GATA3/CCR7/GPR183/MFHAS1/AMPD3/HCLS1/MB/GATA2/CCR2/CXCL6/HOXA5/HIF1A/F2R/BMP4/NFE2L1/JMJD6/NCKAP1L/FANCC/IKZF1/STAT1/TNFRSF17/INPP5D/TNFSF14/CDH2/PTPN2/IL2RA/PRDX2/TRIM58/LAT/CCNB2 40 BP GO:0045807 positive regulation of endocytosis 30/1096 153/18670 4.497e-09 3.448e-07 2.339e-07 MAGI2/IL15RA/IL2RG/ANGPT1/IL2RB/VEGFA/ITGAV/AXL/FCGR2B/IL1B/NEDD4L/SFRP4/RAB27A/PTPRC/CD14/PLCG2/DNM1/GAS6/GATA2/CAV3/RAPGEF1/NTF3/NCKAP1L/HIP1/APOE/SERPINE1/ABR/CCL2/PPP3CC/IL15 30 BP GO:0072676 lymphocyte migration 25/1096 111/18670 4.544e-09 3.448e-07 2.339e-07 CCL5/ADAM8/ITGB7/CXCL13/CCL13/CD200/CH25H/ICAM1/GATA3/PTK2B/CCL18/CCR7/S1PR1/GPR183/IL27RA/ITGA4/GAS6/CCR2/STK10/CCR6/CXCL10/CXCL12/TNFSF14/CCL2/CCL7 25 BP GO:0051235 maintenance of location 48/1096 330/18670 5.444e-09 4.075e-07 2.764e-07 PLCB1/NFKBIE/LPL/FTO/SRGN/DZIP1/ARL2/CORO1A/P2RY6/GSN/ITGAV/ANK3/LCK/ENPP1/FLNB/PTK2B/DAG1/IL1B/HK2/GPSM2/CCR7/PLN/PTPN6/TLN2/NFKBIA/S100A9/NFKB1/NOL3/CCR5/HSPA5/PTPRC/CASQ2/ABCG1/PLCG2/GPAA1/AKAP9/F2R/THY1/PINK1/ATP2A1/KDELR3/VPS13A/KDELR1/APOE/CXCL10/PTPN2/IKBKE/SLC18A2 48 BP GO:0030593 neutrophil chemotaxis 24/1096 104/18670 5.514e-09 4.075e-07 2.764e-07 CCL5/RAC2/CXCL13/CCL13/TGFB2/IL1RN/IL1B/CCL18/CCR7/CXCL8/S100A9/CXCL1/CXCL6/NCKAP1L/PF4/CXCL3/CXCL10/LBP/THBS4/VAV1/ITGB2/C3AR1/CCL2/CCL7 24 BP GO:0009612 response to mechanical stimulus 36/1096 210/18670 5.995e-09 4.374e-07 2.967e-07 SERPINE2/CXCR4/EGFR/TNFRSF10B/IRF1/PTK2B/CD40/PPL/DAG1/IL1B/POSTN/MAPK3/BTG2/NFKBIA/NFKB1/CHI3L1/MYD88/COL1A1/CAV3/ACTA1/GOT1/IGFBP2/CCNB1/TTN/AQP1/BAD/STAT1/CXCL10/HDAC4/CXCL12/TNFSF14/ANGPT2/BNIP3/COL3A1/JUN/MBD2 36 BP GO:0048545 response to steroid hormone 53/1096 385/18670 6.214e-09 4.477e-07 3.036e-07 SPP1/FOXO1/GABRB1/TGFB2/EGFR/ADIPOQ/IL1RN/PCK1/ICAM1/THRA/NTRK3/PGRMC2/STC1/CSN1S1/IGFBP7/PAK1/DAXX/SDC1/NR3C2/ABCA3/PAM/ASS1/PTAFR/CCND1/ALPL/CD38/CNOT1/NPC1/TRIP4/COL1A1/AR/CDO1/TFPI/ACTA1/GOT1/BMP4/IGFBP2/HDAC1/PHB/AQP1/BAD/TLR2/TADA3/HSD11B2/LMO3/KAT5/DDIT4/CARM1/PTGER2/TFAP4/SFRP1/RXRA/PCK2 53 BP GO:1990868 response to chemokine 23/1096 97/18670 6.556e-09 4.606e-07 3.124e-07 CXCR4/CCL5/CXCL13/CCL13/PTK2B/CCL18/CCR7/CXCL8/CCR5/CXCL1/CX3CR1/CCR2/CXCL6/HIF1A/CXCR6/CCR6/PF4/CXCL3/CXCL10/CXCL12/FOXC1/CCL2/CCL7 23 BP GO:1990869 cellular response to chemokine 23/1096 97/18670 6.556e-09 4.606e-07 3.124e-07 CXCR4/CCL5/CXCL13/CCL13/PTK2B/CCL18/CCR7/CXCL8/CCR5/CXCL1/CX3CR1/CCR2/CXCL6/HIF1A/CXCR6/CCR6/PF4/CXCL3/CXCL10/CXCL12/FOXC1/CCL2/CCL7 23 BP GO:0045766 positive regulation of angiogenesis 35/1096 204/18670 9.515e-09 6.604e-07 4.479e-07 CXCR4/SEMA5A/VEGFA/AKT3/PRKCB/PTK2B/ITGAX/CD40/IL1B/HK2/XBP1/HSPB1/CXCL8/CHI3L1/CDH5/SMAD1/CX3CR1/SASH1/PLK2/GATA2/CTSH/HIF1A/ITGA5/HSPB6/AQP1/SERPINE1/ADAM12/C6/TWIST1/AGTR1/ITGB2/C3AR1/ANGPT2/HYAL1/FLT1 35 BP GO:0043405 regulation of MAP kinase activity 48/1096 337/18670 1.082e-08 7.421e-07 5.034e-07 CXCR4/ADAM8/TGFA/VEGFA/EGFR/ADIPOQ/RASGRP1/DUSP5/NTRK3/PTK2B/CD40/IL1B/PAK1/DAXX/MAPK3/ADORA1/PTPN6/MAP3K4/RGS2/PTPRC/TRIB2/MAGED1/INSR/DUSP14/FGFR1/SASH1/PTPN22/CAV3/RAPGEF1/F2R/UCHL1/BMP4/MAP4K1/NTF3/MAPK10/APOE/NGF/DUSP2/CSK/ARHGEF5/SFRP1/DUSP3/TENM1/IKBKG/SPRY1/PRDX2/ELANE/FLT1 48 BP GO:0050708 regulation of protein secretion 60/1096 472/18670 1.312e-08 8.891e-07 6.03e-07 FCN1/TNFAIP3/TNFRSF1B/IL4R/LPL/CCL5/ADAM8/SRGN/ANGPT1/ARL2/TGFB2/CD200/EGFR/RASGRP1/GATA3/AIM2/CD40/FCGR2B/TCF7L2/IL1B/POSTN/CD2/CCR7/RBP4/XBP1/MAPK3/IL27RA/PAM/SPTBN1/CD38/MYH10/ICA1/CRTAM/CD14/LILRA2/ABCG1/HADH/OXCT1/GAS6/PTPN22/HIF1A/F2R/EFNA5/UNC13B/TNFRSF4/LRP5/TTN/IL17RA/BAD/TLR2/GBP1/APOE/SLC25A4/TWIST1/NLRP3/SFRP1/MYOM1/INHBB/NNAT/GLMN 60 BP GO:0001655 urogenital system development 47/1096 330/18670 1.542e-08 1.032e-06 7.003e-07 ZBTB16/MAGI2/ANGPT1/WWTR1/TGFB2/VEGFA/ADIPOQ/SIX1/GATA3/AKR1B1/SMAD3/SULF1/SDC1/RBP4/ID3/RGN/ASS1/MAGED1/SMAD1/AR/FGFR1/DLG5/GATA2/CTSH/ACTA2/ID4/BMP4/PECAM1/NFIA/JMJD6/BASP1/STAT1/CTNNBIP1/LAMB2/AGTR1/FOXC1/SFRP1/ANGPT2/OSR2/PDGFRA/HOXA11/WFS1/SPRY1/SMAD6/RXRA/COL4A1/CRLF1 47 BP GO:1903706 regulation of hemopoiesis 60/1096 475/18670 1.66e-08 1.099e-06 7.451e-07 RUNX3/IL4R/ZBTB16/ADAM8/IL7R/ADIPOQ/AXL/RASGRP1/LILRB2/ADA/IRF1/GATA3/PRKCB/PTK2B/TCTA/FCGR2B/CD2/XBP1/LILRB4/PTPN6/NFKBIA/PTPRC/CD83/MYL9/EGR3/CD27/HCLS1/GAS6/GATA2/PAF1/CCR2/HOXA5/HIF1A/BMP4/PIM1/HDAC1/ZMIZ1/NCKAP1L/LAG3/PF4/BAD/STAT1/CTNNBIP1/LILRB3/IRF7/CD86/NLRP3/APCS/INPP5D/FOXC1/CNOT4/SFRP1/PTPN2/SART1/IL2RA/CUL4A/PRDX2/TRIM58/IL15/JUN 60 BP GO:0007162 negative regulation of cell adhesion 43/1096 289/18670 1.728e-08 1.131e-06 7.668e-07 RUNX3/IL4R/SERPINE2/ANGPT1/ADAMDEC1/SEMA5A/VEGFA/SEMA3E/ADIPOQ/IL1RN/LILRB2/IRF1/FCGR2B/POSTN/PTPN6/ASS1/PTPRC/COL1A1/ARHGDIB/DLG5/PTPN22/KANK1/BMP4/DLC1/EFNA5/MAPK7/FZD7/LAG3/PRKG1/GBP1/PLXNC1/SERPINE1/CD86/PLXNA2/CXCL12/LPXN/DUSP3/PTPN2/ANGPT2/IL2RA/SPINT2/PRDX2/GLMN 43 BP GO:0003007 heart morphogenesis 40/1096 259/18670 1.89e-08 1.223e-06 8.292e-07 TGFBR3/PARVA/TGFB2/VEGFA/SIX1/GATA3/SMAD3/S1PR1/RBP4/FZD2/MYL2/INSR/MYOM2/MYH7/OLFM1/TNNC1/CAV3/SEMA3C/MYL3/SMARCD3/HIF1A/BMP4/DLC1/PIM1/TNNI1/ZMIZ1/TTN/MYBPC2/UBE4B/DHRS3/BMPR1A/TWIST1/FOXC1/NRP2/SPRY1/SMAD6/MYOM1/RXRA/STIL/JUN 40 BP GO:0051090 regulation of DNA-binding transcription factor activity 56/1096 432/18670 2.026e-08 1.296e-06 8.788e-07 TNFAIP3/NFKBIE/DDR2/ADAM8/VEGFA/CD200/ICAM1/ENPP1/PRKCB/AIM2/CD40/NUPR1/TCF7L2/NFKB2/IL1B/TP53BP1/SMAD3/MAPK3/ADORA3/SIK1/SFRP4/FZD2/ID3/DAP/NFKBIA/S100A9/NFKB1/TRAF1/MID2/MYD88/ID1/HCLS1/CX3CR1/AR/GAS6/PINK1/PIM1/TNFRSF4/ERC1/MAPK10/TLR2/USP7/CTNNBIP1/PRKCH/HDAC4/TWIST1/NLRP3/ARHGEF5/TRAF3/CARM1/ITGB2/WFS1/IKBKG/PRDX2/JUN/ADCY1 56 BP GO:0034612 response to tumor necrosis factor 45/1096 312/18670 2.119e-08 1.329e-06 9.012e-07 TNFAIP3/TNFRSF1B/CCL5/CCL13/FABP4/ADIPOQ/PCK1/ICAM1/GATA3/AIM2/PTK2B/BIRC3/CD40/CPNE1/CCL18/POSTN/MAPK3/GCH1/CXCL8/NFKBIA/ASS1/NFKB1/NOL3/CHI3L1/TRAF1/CD14/CD27/COL1A1/GAS6/CASP4/TNFRSF4/GBP2/STAT1/GBP1/TNFRSF17/HDAC4/PRPF8/TRAF3/TNFSF14/SFRP1/PTPN2/CCL2/IKBKG/CCL7/HYAL1 45 BP GO:0071356 cellular response to tumor necrosis factor 43/1096 291/18670 2.125e-08 1.329e-06 9.012e-07 TNFAIP3/TNFRSF1B/CCL5/CCL13/FABP4/ADIPOQ/PCK1/ICAM1/GATA3/AIM2/PTK2B/BIRC3/CD40/CPNE1/CCL18/POSTN/MAPK3/CXCL8/NFKBIA/ASS1/NFKB1/NOL3/CHI3L1/TRAF1/CD27/COL1A1/GAS6/CASP4/TNFRSF4/GBP2/STAT1/GBP1/TNFRSF17/HDAC4/PRPF8/TRAF3/TNFSF14/SFRP1/PTPN2/CCL2/IKBKG/CCL7/HYAL1 43 BP GO:1901342 regulation of vasculature development 55/1096 422/18670 2.248e-08 1.391e-06 9.434e-07 TNFAIP3/CXCR4/CXCL13/MECP2/SEMA5A/TGFB2/VEGFA/SEMA3E/EMP2/AKT3/PRKCB/PTK2B/ITGAX/CD40/THBS2/IL1B/SULF1/HK2/XBP1/HSPB1/CXCL8/CHI3L1/CDH5/SMAD1/ID1/CX3CR1/SASH1/PLK2/GATA2/CTSH/CCR2/HOXA5/HIF1A/BMP4/ITGA5/HSPB6/MAPK7/AQP1/PF4/STAT1/SERPINE1/ADAM12/CXCL10/C6/TWIST1/THBS4/AGTR1/FOXC1/SFRP1/ITGB2/C3AR1/ANGPT2/HYAL1/FLT1/AMOT 55 BP GO:0072001 renal system development 43/1096 293/18670 2.606e-08 1.595e-06 1.082e-06 ZBTB16/MAGI2/ANGPT1/WWTR1/TGFB2/VEGFA/ADIPOQ/SIX1/GATA3/AKR1B1/SMAD3/SULF1/SDC1/RBP4/ID3/RGN/ASS1/MAGED1/SMAD1/FGFR1/DLG5/CTSH/ACTA2/BMP4/PECAM1/NFIA/JMJD6/BASP1/STAT1/CTNNBIP1/LAMB2/AGTR1/FOXC1/SFRP1/ANGPT2/OSR2/PDGFRA/HOXA11/WFS1/SPRY1/SMAD6/COL4A1/CRLF1 43 BP GO:0007596 blood coagulation 47/1096 336/18670 2.726e-08 1.636e-06 1.11e-06 SERPINE2/SH2B2/HBB/STXBP1/AXL/LCK/SERPINA1/IRF1/GATA3/PRKCB/CD40/PLEK/MAPK3/HSPB1/PTPN6/DOCK1/RAB27A/GNA11/PDPN/CSRP1/LCP2/PLSCR1/MYL9/PLCG2/COL1A1/GAS6/TFPI/GATA2/F2R/PLAUR/PAPSS2/HDAC1/PF4/F8/PRKG1/APOE/SERPINE1/PRKCH/MAFF/VAV1/PDGFRA/TFPI2/COL3A1/PRDX2/TYRO3/SELP/HBE1 47 BP GO:1901654 response to ketone 33/1096 193/18670 2.731e-08 1.636e-06 1.11e-06 SPP1/FOXO1/TGFBR3/GABRB1/P2RY6/TGFB2/EGFR/PCK1/ICAM1/NTRK3/AKR1B1/CSN1S1/CCR7/IGFBP7/PLN/ASS1/PTAFR/CCND1/CD38/AR/ADCY6/EFNA5/MAP4K1/CDK4/AQP1/BAD/TLR2/DDIT4/PTGER2/TFAP4/SFRP1/PCK2/ADCY1 33 BP GO:0046718 viral entry into host cell 25/1096 121/18670 2.896e-08 1.717e-06 1.165e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CCR5/NPC1/MID2/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/CD86/APCS/TFRC/TYRO3/SIVA1/HYAL1 25 BP GO:0048511 rhythmic process 43/1096 295/18670 3.188e-08 1.871e-06 1.269e-06 GABRB1/EGR2/HUWE1/RELB/TGFB2/EGFR/ADIPOQ/AXL/PHLPP1/HLF/ADA/NTRK3/TIMP4/NFKB2/NAMPT/ADORA1/SIK1/ID3/PAM/ASS1/GNA11/HSPA5/CRX/GFPT1/MAGED1/ID1/EGR3/ID4/CDK4/HDAC1/AHCY/MAPK10/USP7/SERPINE1/TWIST1/PDGFRA/IMPDH2/CUL4A/PTGDS/TYRO3/ATF5/JUN/ADCY1 43 BP GO:0052547 regulation of peptidase activity 57/1096 452/18670 4.027e-08 2.338e-06 1.586e-06 SERPINE2/CRYAB/VEGFA/SPOCK2/GSN/TNFRSF10B/LCK/SLPI/SERPINA1/TIMP4/AIM2/BIN1/BIRC3/RARRES1/SMAD3/CTSD/MAPK3/DAP/APLP2/S100A9/NOL3/TNFSF10/CD44/ASPH/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/CTSH/CASP4/SERPINB8/F2R/PINK1/LAMP3/DLC1/GPX1/PLAUR/HDAC1/AQP1/TIMP3/HIP1/BAD/GRAMD4/NGF/SERPINE1/NLRP3/TNFSF14/TFAP4/LGMN/SPINT2/TFPI2/CYFIP2/PCOLCE/HERPUD1 57 BP GO:0007599 hemostasis 47/1096 341/18670 4.324e-08 2.485e-06 1.685e-06 SERPINE2/SH2B2/HBB/STXBP1/AXL/LCK/SERPINA1/IRF1/GATA3/PRKCB/CD40/PLEK/MAPK3/HSPB1/PTPN6/DOCK1/RAB27A/GNA11/PDPN/CSRP1/LCP2/PLSCR1/MYL9/PLCG2/COL1A1/GAS6/TFPI/GATA2/F2R/PLAUR/PAPSS2/HDAC1/PF4/F8/PRKG1/APOE/SERPINE1/PRKCH/MAFF/VAV1/PDGFRA/TFPI2/COL3A1/PRDX2/TYRO3/SELP/HBE1 47 BP GO:0018108 peptidyl-tyrosine phosphorylation 49/1096 363/18670 4.366e-08 2.485e-06 1.685e-06 DDR2/CCL5/ANGPT1/TGFA/VEGFA/EPHA3/EGFR/ADIPOQ/AXL/ITK/LCK/ICAM1/HBEGF/NTRK3/PTK2B/CD40/MAPK3/ADORA1/PTPN6/CD44/PTPRC/CLK1/INSR/PAK2/HCLS1/FGFR1/GAS6/NEK1/INPP5F/DYRK2/THY1/ITGA5/EFNA5/PECAM1/NTF3/EFEMP1/TTN/SLA/CSK/THBS4/SFRP1/ITGB2/PTPN2/FGFR3/PDGFRA/TYRO3/CRLF1/FLT1/IL15 49 BP GO:0002791 regulation of peptide secretion 61/1096 500/18670 4.568e-08 2.574e-06 1.746e-06 FCN1/TNFAIP3/TNFRSF1B/IL4R/LPL/CCL5/ADAM8/SRGN/ANGPT1/ARL2/TGFB2/CD200/EGFR/RASGRP1/GATA3/AIM2/CD40/FCGR2B/TCF7L2/IL1B/POSTN/CD2/CCR7/RBP4/XBP1/MAPK3/ADORA1/IL27RA/PAM/SPTBN1/CD38/MYH10/ICA1/CRTAM/CD14/LILRA2/ABCG1/HADH/OXCT1/GAS6/PTPN22/HIF1A/F2R/EFNA5/UNC13B/TNFRSF4/LRP5/TTN/IL17RA/BAD/TLR2/GBP1/APOE/SLC25A4/TWIST1/NLRP3/SFRP1/MYOM1/INHBB/NNAT/GLMN 61 BP GO:0050817 coagulation 47/1096 342/18670 4.735e-08 2.642e-06 1.792e-06 SERPINE2/SH2B2/HBB/STXBP1/AXL/LCK/SERPINA1/IRF1/GATA3/PRKCB/CD40/PLEK/MAPK3/HSPB1/PTPN6/DOCK1/RAB27A/GNA11/PDPN/CSRP1/LCP2/PLSCR1/MYL9/PLCG2/COL1A1/GAS6/TFPI/GATA2/F2R/PLAUR/PAPSS2/HDAC1/PF4/F8/PRKG1/APOE/SERPINE1/PRKCH/MAFF/VAV1/PDGFRA/TFPI2/COL3A1/PRDX2/TYRO3/SELP/HBE1 47 BP GO:0043491 protein kinase B signaling 40/1096 269/18670 5.516e-08 3.047e-06 2.067e-06 MAGI2/CCL5/ADAM8/RAC2/ANGPT1/SEMA5A/TGFA/EGFR/AXL/PHLPP1/LCK/HBEGF/GATA3/CD40/CPNE1/DAG1/TCF7L2/IL1B/CCR7/BTC/CHI3L1/MFHAS1/INSR/HCLS1/CX3CR1/FGFR1/GAS6/INPP5F/CAV3/RAPGEF1/PINK1/GPX1/IGFBP5/HIP1/CD86/VAV1/FGFR3/CCL2/PDGFRA/TYRO3 40 BP GO:0018212 peptidyl-tyrosine modification 49/1096 366/18670 5.671e-08 3.103e-06 2.105e-06 DDR2/CCL5/ANGPT1/TGFA/VEGFA/EPHA3/EGFR/ADIPOQ/AXL/ITK/LCK/ICAM1/HBEGF/NTRK3/PTK2B/CD40/MAPK3/ADORA1/PTPN6/CD44/PTPRC/CLK1/INSR/PAK2/HCLS1/FGFR1/GAS6/NEK1/INPP5F/DYRK2/THY1/ITGA5/EFNA5/PECAM1/NTF3/EFEMP1/TTN/SLA/CSK/THBS4/SFRP1/ITGB2/PTPN2/FGFR3/PDGFRA/TYRO3/CRLF1/FLT1/IL15 49 BP GO:0048732 gland development 55/1096 434/18670 5.901e-08 3.107e-06 2.107e-06 TNFAIP3/TGFBR3/SERPINE2/TGFB2/VEGFA/EGFR/SEMA3A/SIX1/PCK1/NFIB/ADA/THRA/GATA3/DAG1/SMAD3/SULF1/HK2/XBP1/MAPK3/RGN/TGM2/PAM/PITX1/ASS1/GOT2/CCND1/INSR/AR/FGFR1/CDO1/GATA2/CAV3/SEMA3C/HOXA5/HIF1A/ID4/BMP4/GPX1/LRP5/IGFBP5/SEC63/QDPR/BMPR1A/JARID2/ARHGAP5/FOXC1/SFRP1/COBL/PDGFRA/OAS2/RXRA/PRDX2/PCK2/JUN/CCNB2 55 BP GO:0030260 entry into host cell 26/1096 134/18670 5.95e-08 3.107e-06 2.107e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CXCL8/CCR5/NPC1/MID2/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/CD86/APCS/TFRC/TYRO3/SIVA1/HYAL1 26 BP GO:0044409 entry into host 26/1096 134/18670 5.95e-08 3.107e-06 2.107e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CXCL8/CCR5/NPC1/MID2/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/CD86/APCS/TFRC/TYRO3/SIVA1/HYAL1 26 BP GO:0051806 entry into cell of other organism involved in symbiotic interaction 26/1096 134/18670 5.95e-08 3.107e-06 2.107e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CXCL8/CCR5/NPC1/MID2/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/CD86/APCS/TFRC/TYRO3/SIVA1/HYAL1 26 BP GO:0051828 entry into other organism involved in symbiotic interaction 26/1096 134/18670 5.95e-08 3.107e-06 2.107e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CXCL8/CCR5/NPC1/MID2/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/CD86/APCS/TFRC/TYRO3/SIVA1/HYAL1 26 BP GO:2000116 regulation of cysteine-type endopeptidase activity 37/1096 239/18670 6.017e-08 3.113e-06 2.112e-06 CRYAB/VEGFA/GSN/TNFRSF10B/LCK/AIM2/BIRC3/SMAD3/CTSD/DAP/S100A9/NOL3/TNFSF10/CD44/ASPH/CST7/PAK2/CD27/GAS6/CTSH/CASP4/F2R/LAMP3/DLC1/GPX1/PLAUR/AQP1/HIP1/BAD/GRAMD4/NGF/NLRP3/TNFSF14/TFAP4/LGMN/CYFIP2/HERPUD1 37 BP GO:0072503 cellular divalent inorganic cation homeostasis 60/1096 493/18670 6.432e-08 3.298e-06 2.237e-06 PLCB1/CXCR4/CCL5/CXCL13/CORO1A/CCL13/P2RY6/ITGAV/LCK/PRKCB/PTK2B/CALB2/CD40/STC1/SMAD3/CCR7/S1PR1/ADORA1/PLN/PTPN6/RGN/TGM2/S100A9/NOL3/CCR5/NMB/CD38/PTPRC/CDH5/CASQ2/SLC39A8/PLCG2/MT1G/CX3CR1/GATA2/CCR2/CAV3/F2R/THY1/CXCR6/GOT1/SLC39A14/ATP2A1/CCR6/APOE/CXCL10/SLC39A7/CXCL12/AGTR1/PTGER2/C3AR1/ATP13A3/PDGFRA/BNIP3/WFS1/S1PR4/CD52/ELANE/CCL7/HERPUD1 60 BP GO:0050663 cytokine secretion 37/1096 240/18670 6.721e-08 3.415e-06 2.316e-06 FCN1/TNFAIP3/TNFRSF1B/IL4R/LPL/SRGN/ANGPT1/ITGAV/CD200/RASGRP1/GATA3/AIM2/FCGR2B/IL1B/POSTN/CD2/CCR7/XBP1/MAPK3/IL27RA/SPTBN1/CHI3L1/CRTAM/CD14/LILRA2/LCP2/GAS6/PTPN22/S100A13/F2R/TNFRSF4/IL17RA/TLR2/GBP1/TWIST1/NLRP3/GLMN 37 BP GO:0052548 regulation of endopeptidase activity 54/1096 425/18670 7.137e-08 3.594e-06 2.438e-06 SERPINE2/CRYAB/VEGFA/SPOCK2/GSN/TNFRSF10B/LCK/SLPI/SERPINA1/TIMP4/AIM2/BIN1/BIRC3/RARRES1/SMAD3/CTSD/DAP/APLP2/S100A9/NOL3/TNFSF10/CD44/ASPH/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/CTSH/CASP4/SERPINB8/F2R/LAMP3/DLC1/GPX1/PLAUR/HDAC1/AQP1/TIMP3/HIP1/BAD/GRAMD4/NGF/SERPINE1/NLRP3/TNFSF14/TFAP4/LGMN/SPINT2/TFPI2/CYFIP2/HERPUD1 54 BP GO:0035690 cellular response to drug 49/1096 369/18670 7.339e-08 3.664e-06 2.485e-06 FOXO1/PLCB1/TNFAIP3/CXCR4/EGFR/ADIPOQ/AXL/ADIRF/PCK1/ICAM1/AIM2/PCGF2/ATRX/IL1B/DAXX/MAPK3/ASS1/GNA11/NFKB1/PTAFR/HSPA5/CASQ2/LDOC1/ID1/TRAP1/ADCY6/GAS6/PTPN22/PINK1/CCNA2/EFNA5/NQO1/MAP4K1/CDK4/MAPK7/AQP1/BAD/QDPR/MAPK13/DDIT4/TFRC/TFAP4/SFRP1/BNIP3/CD69/CCL7/PCK2/CHRM3/ADCY1 49 BP GO:0051146 striated muscle cell differentiation 42/1096 293/18670 7.443e-08 3.683e-06 2.498e-06 IL4R/TMOD1/VEGFA/SORBS2/CDON/SIX1/PAK1/SDC1/XBP1/SIK1/TNNT1/MYL2/LDB3/MYH11/RGS2/MYH10/CASQ2/CSRP1/MYOM2/CD53/CAV3/PIN1/UCHL1/ACTA1/BMP4/GPX1/FZD7/CCNB1/TTN/IGFBP5/MYBPC2/NEB/ADAM12/CXCL10/HDAC4/PDLIM5/TNFSF14/CDH2/CBY1/PDGFRA/MYOM1/RXRA 42 BP GO:0016049 cell growth 59/1096 484/18670 7.828e-08 3.841e-06 2.605e-06 SPP1/SERPINE2/CXCR4/CRYAB/SEMA5A/TGFB2/VEGFA/SORBS2/SEMA3E/EGFR/SEMA3A/CLSTN1/ENPP1/HBEGF/NTRK3/DCLK1/PTK2B/CPNE1/POSTN/ADIPOR2/SMAD3/AUTS2/IGFBP7/PAK1/NEDD4L/KAZALD1/MYL2/S100A9/FBLN5/CD38/RGS2/CDKN2C/ITGA4/OLFM1/SYT17/CAV3/SEMA3C/PIN1/LTBP4/SEMA4F/EFNA5/PHB/IGFBP5/APOE/NGF/CTTN/PDLIM5/CXCL12/KIAA1109/LAMB2/AGTR1/SFRP1/NRP2/COBL/FHL1/DPYSL2/TSPYL2/CYFIP2/HYAL1 59 BP GO:0000302 response to reactive oxygen species 36/1096 232/18670 8.527e-08 4.148e-06 2.813e-06 FOXO1/TNFAIP3/CRYAB/HBB/EGFR/AXL/ADA/PCGF2/PTK2B/EEF2/CCR7/SDC1/MAPK3/GCH1/RGN/FBLN5/PDK2/TRAP1/COL1A1/MB/PINK1/CCNA2/GPX1/NQO1/MAPK7/AQP1/BAD/FANCC/STAT1/APOE/MAPK13/PDGFRA/BNIP3/PRDX2/HYAL1/JUN 36 BP GO:0006979 response to oxidative stress 56/1096 451/18670 9.007e-08 4.344e-06 2.946e-06 FOXO1/TNFAIP3/CRYAB/HBB/PTGS1/PDLIM1/EGFR/ADIPOQ/AXL/PXDN/ADA/GPX3/PCGF2/PTK2B/EEF2/GPX4/CCR7/SDC1/MAPK3/HSPB1/GCH1/RGN/SLC23A2/FBLN5/NOL3/CD38/PDK2/TRAP1/COL1A1/MB/ANGPTL7/ERCC1/HIF1A/ALDH3B1/PINK1/ACOX2/CCNA2/GPX1/NQO1/MAPK7/NFE2L1/AQP1/BAD/FANCC/STAT1/APOE/PSIP1/CA3/MAPK13/LPO/NCF2/PDGFRA/BNIP3/PRDX2/HYAL1/JUN 56 BP GO:0097305 response to alcohol 36/1096 233/18670 9.529e-08 4.557e-06 3.091e-06 TGFBR3/P2RY6/GSN/ADIPOQ/ICAM1/GATA3/NTRK3/PTK2B/DAG1/EEF2/CSN1S1/CCR7/IGFBP7/RBP4/CCR5/GOT2/CCND1/RGS2/CD14/CD27/OXCT1/ADCY6/CDO1/EFNA5/NQO1/MAP4K1/CDK4/NFE2L1/BAD/PMVK/USP46/CA3/PTGER2/SFRP1/CCL7/ADCY1 36 BP GO:0001933 negative regulation of protein phosphorylation 54/1096 429/18670 9.752e-08 4.625e-06 3.137e-06 FOXO1/TNFAIP3/ANGPT1/WWTR1/FABP4/ADIPOQ/DUSP5/ENPP1/PTPN13/NTRK3/GFRA2/DAG1/IL1B/HSPB1/PTPN6/RGN/RGS2/CDKN2C/PTPRC/TRIB2/PAK2/DUSP14/PKIG/PTPN22/INPP5F/CAV3/PIN1/RAPGEF1/THY1/PINK1/UCHL1/LDLRAD4/BMP4/NTF3/CCNB1/LRP5/GMFG/PHB/TIMP3/GBP1/APOE/LMO3/DUSP2/CSK/DDIT4/TWIST1/TFAP4/SFRP1/DUSP3/PTPN2/PLK1/SPRY1/SMAD6/JUN 54 BP GO:0051222 positive regulation of protein transport 53/1096 418/18670 1.01e-07 4.75e-06 3.222e-06 FCN1/IL4R/LPL/ADAM8/RAC2/HUWE1/TGFB2/EGFR/RASGRP1/ANK3/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/SMAD3/ZIC1/PAK1/RBP4/XBP1/MAPK3/SPTBN1/CD38/MYH10/CRTAM/CD14/LILRA2/RAB29/ABCG1/TM9SF4/HCLS1/OXCT1/GAS6/PTPN22/HIF1A/F2R/PINK1/UNC13B/TNFRSF4/TTN/IL17RA/BAD/TLR2/TWIST1/NLRP3/ARHGEF5/ITGB2/PPM1A/TENM1/MYOM1/NNAT/GLMN 53 BP GO:0097191 extrinsic apoptotic signaling pathway 35/1096 224/18670 1.08e-07 5.037e-06 3.416e-06 TNFAIP3/TNFRSF1B/TGFB2/ITGAV/TNFRSF10B/ICAM1/TCF7L2/IL1B/SMAD3/BCL2L2/DAXX/NOL3/TNFSF10/PTPRC/TRAF1/PAK2/CD27/AR/FGFR1/G0S2/BMP4/GPX1/MAPK7/TIMP3/PF4/BAD/BCL2A1/NGF/SERPINE1/MLLT11/CTTN/SFRP1/FGFR3/PRDX2/SIVA1 35 BP GO:0002449 lymphocyte mediated immunity 47/1096 352/18670 1.146e-07 5.301e-06 3.596e-06 TRBC1/TNFRSF1B/IL4R/IL7R/CORO1A/GZMB/RASGRP1/ICAM1/CD226/EMP2/CD8A/GATA3/SH2D1A/CD40/FCGR2B/IL1B/RFTN1/TP53BP1/PTPN6/IL27RA/BATF/RAB27A/CTSC/PTPRC/CRTAM/HPRT1/CD27/CTSH/CCR2/ERCC1/PARP3/IGKC/CFI/CCR6/LAG3/KDELR1/IGLV6-57/C6/IRF7/NLRP3/APCS/INPP5D/VAV1/TFRC/IGLC1/C7/KLRD1 47 BP GO:1904951 positive regulation of establishment of protein localization 56/1096 456/18670 1.308e-07 5.96e-06 4.043e-06 FCN1/IL4R/LPL/ADAM8/RAC2/HUWE1/TGFB2/GZMB/EGFR/RASGRP1/ANK3/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/SMAD3/ZIC1/PAK1/RBP4/XBP1/MAPK3/SPTBN1/CD38/MYH10/CRTAM/CD14/LILRA2/RAB29/ABCG1/TM9SF4/HCLS1/OXCT1/GAS6/PTPN22/HIF1A/F2R/PINK1/UNC13B/TNFRSF4/TTN/IL17RA/BAD/TLR2/TWIST1/NLRP3/ARHGEF5/PTP4A3/ITGB2/PPM1A/TENM1/MYOM1/PPP3CC/NNAT/GLMN 56 BP GO:0048010 vascular endothelial growth factor receptor signaling pathway 21/1096 96/18670 1.316e-07 5.96e-06 4.043e-06 VEGFA/ITGAV/AXL/PRKCB/PTK2B/IL1B/SULF1/SH2D2A/HSPB1/DOCK1/PAK2/HIF1A/ITGA5/NCKAP1/NCKAP1L/VAV1/FOXC1/NRP2/NCF2/CYFIP2/FLT1 21 BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 17/1096 65/18670 1.32e-07 5.96e-06 4.043e-06 LCK/CD226/ADA/PRKCB/FCGR2B/CCR7/LILRB4/PTPN6/PTPRC/RAB29/PTPN22/THY1/GBP1/PRKCH/LPXN/DUSP3/PTPN2 17 BP GO:0035051 cardiocyte differentiation 29/1096 167/18670 1.331e-07 5.96e-06 4.043e-06 TGFBR3/TGFB2/VEGFA/SORBS2/EGFR/PAK1/MAPK3/SIK1/MYL2/MYH11/RGS2/MYH10/MYOM2/CAV3/SEMA3C/PIN1/BMP4/FZD7/CCNB1/TTN/MYBPC2/NEB/PDLIM5/TWIST1/CBY1/PDGFRA/SPRY1/MYOM1/RXRA 29 BP GO:0042326 negative regulation of phosphorylation 57/1096 468/18670 1.341e-07 5.96e-06 4.043e-06 FOXO1/TNFAIP3/ANGPT1/RHOH/WWTR1/FABP4/ADIPOQ/DUSP5/ENPP1/PTPN13/NTRK3/GFRA2/DAG1/NUPR1/IL1B/HSPB1/PTPN6/RGN/RGS2/CDKN2C/PTPRC/TRIB2/PAK2/DUSP14/PKIG/PTPN22/INPP5F/CAV3/PIN1/RAPGEF1/THY1/PINK1/UCHL1/LDLRAD4/BMP4/NTF3/CCNB1/LRP5/GMFG/PHB/TIMP3/GBP1/APOE/LMO3/DUSP2/HDAC4/CSK/DDIT4/TWIST1/TFAP4/SFRP1/DUSP3/PTPN2/PLK1/SPRY1/SMAD6/JUN 57 BP GO:1903532 positive regulation of secretion by cell 51/1096 399/18670 1.363e-07 5.988e-06 4.062e-06 SPP1/FCN1/IL4R/LPL/ADAM8/TGFB2/STXBP1/EGFR/RASGRP1/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/SDC1/RBP4/XBP1/MAPK3/GAB2/RAB27A/PTAFR/SPTBN1/NMB/CD38/MYH10/CRTAM/CD14/LILRA2/ABCG1/OXCT1/FGFR1/GATA2/PTPN22/HIF1A/F2R/PINK1/UNC13B/TNFRSF4/TTN/IL17RA/BAD/TLR2/CXCL12/TWIST1/NLRP3/ITGB2/MYOM1/INHBB/NNAT/GLMN 51 BP GO:0001822 kidney development 40/1096 278/18670 1.368e-07 5.988e-06 4.062e-06 ZBTB16/MAGI2/ANGPT1/WWTR1/TGFB2/VEGFA/ADIPOQ/SIX1/GATA3/AKR1B1/SMAD3/SULF1/SDC1/ID3/RGN/ASS1/MAGED1/SMAD1/FGFR1/DLG5/CTSH/ACTA2/BMP4/PECAM1/JMJD6/BASP1/STAT1/CTNNBIP1/LAMB2/AGTR1/FOXC1/SFRP1/ANGPT2/OSR2/PDGFRA/HOXA11/WFS1/SPRY1/SMAD6/CRLF1 40 BP GO:0032970 regulation of actin filament-based process 50/1096 388/18670 1.4e-07 6.084e-06 4.126e-06 TMOD1/CORO1A/SEMA5A/RHOH/GSN/EPHA3/SEMA3E/ICAM1/CDK10/NTRK3/BIN1/ARHGEF10/PTK2B/STC1/RHOBTB3/PLEK/SMAD3/CCR7/PAK1/S1PR1/ADORA1/PLN/PAM/SPTBN1/PDPN/ID1/HCLS1/ARHGDIB/CAPG/TNNC1/KANK1/CAV3/AKAP9/DLC1/EFNA5/ATP2A1/NTF3/GMFG/NCKAP1/NCKAP1L/RHOBTB1/NEB/CTTN/ARPC3/CXCL12/ARHGEF5/SFRP1/TENM1/PDGFRA/PFN2 50 BP GO:0050678 regulation of epithelial cell proliferation 49/1096 378/18670 1.555e-07 6.706e-06 4.549e-06 RUNX3/TNFAIP3/TGFBR3/CCL5/SEMA5A/TGFA/TGFB2/VEGFA/EGFR/SIX1/NFIB/AKT3/GATA3/NUPR1/TCF7L2/SMAD3/SULF1/XBP1/RGN/CCND1/MAGED1/ITGA4/ID1/EGR3/AR/FGFR1/GATA2/HOXA5/HIF1A/BMP4/GPX1/FZD7/BAD/HTRA1/STAT1/APOE/BMPR1A/CXCL12/TWIST1/THBS4/AGTR1/SFRP1/NRP2/CCL2/OSR2/NRAS/HYAL1/FLT1/JUN 49 BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 39/1096 269/18670 1.598e-07 6.837e-06 4.638e-06 TNFAIP3/LITAF/ANGPT1/RHOH/RELB/ADIPOQ/TNFRSF10B/IL1RN/PRKCB/BIRC3/CD40/CPNE1/IL1B/CCR7/HSPB1/TGM2/NFKBIA/SLC20A1/TNFSF10/LY96/SECTM1/MID2/CD14/MYD88/CX3CR1/PLK2/S100A13/F2R/PINK1/ERC1/HDAC1/TLR2/PIM2/STAT1/PPM1A/EEF1D/IKBKG/IKBKE/VAPA 39 BP GO:0033002 muscle cell proliferation 36/1096 239/18670 1.825e-07 7.751e-06 5.257e-06 TNFAIP3/TGFBR3/CCL5/ANGPT1/P2RY6/TGFB2/PDE1A/EGFR/ADIPOQ/SIX1/HBEGF/TCF7L2/AKR1B1/NAMPT/PAK1/S1PR1/RBP4/TGM2/PTAFR/SMAD1/FGFR1/BMP4/PIM1/CCNB1/IGFBP5/PRKG1/STAT1/CTNNBIP1/HDAC4/BMPR1A/JARID2/FOXC1/RXRA/ELANE/IL15/JUN 36 BP GO:0002429 immune response-activating cell surface receptor signaling pathway 57/1096 473/18670 1.921e-07 8.074e-06 5.476e-06 CD247/TRBC1/CD3D/FCN1/SH2B2/RELB/CLEC10A/ITK/LCK/CD226/ADA/GATA3/PRKCB/FCGR2B/RFTN1/CCR7/PAK1/MAPK3/LILRB4/PTPN6/DOCK1/NFKB1/CD38/PTPRC/MYH2/LILRA2/LCP2/RAB29/PLSCR1/PLCG2/THEMIS2/PAK2/CD3G/SKAP1/PTPN22/RAPGEF1/THY1/FCGR2A/IGKC/NCKAP1/NCKAP1L/GBP1/IGLV6-57/PRKCH/ARPC3/CSK/INPP5D/VAV1/LPXN/IGLC1/DUSP3/C3AR1/PTPN2/NRAS/IKBKG/CYFIP2/LAT 57 BP GO:0051701 interaction with host 33/1096 209/18670 1.93e-07 8.074e-06 5.476e-06 FCN1/CXCR4/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/NTRK3/DAG1/SLAMF1/SMAD3/SELPLG/CXCL8/CCR5/NPC1/MID2/INSR/PC/HAVCR1/GAS6/SLC20A2/ITGA5/TNFRSF4/BAD/CD86/APCS/TFRC/RXRA/TYRO3/SIVA1/VAPA/HYAL1 33 BP GO:1904018 positive regulation of vasculature development 35/1096 230/18670 2.092e-07 8.667e-06 5.879e-06 CXCR4/SEMA5A/VEGFA/AKT3/PRKCB/PTK2B/ITGAX/CD40/IL1B/HK2/XBP1/HSPB1/CXCL8/CHI3L1/CDH5/SMAD1/CX3CR1/SASH1/PLK2/GATA2/CTSH/HIF1A/ITGA5/HSPB6/AQP1/SERPINE1/ADAM12/C6/TWIST1/AGTR1/ITGB2/C3AR1/ANGPT2/HYAL1/FLT1 35 BP GO:0030099 myeloid cell differentiation 52/1096 416/18670 2.102e-07 8.667e-06 5.879e-06 TGFBR3/ZBTB16/RELB/VEGFA/ADIPOQ/THRA/GATA3/PRKCB/PTK2B/TCTA/ACTN1/CCR7/LILRB4/PTPN6/GPR183/GAB2/NFKBIA/BATF/MFHAS1/MYL9/MT1G/HCLS1/MB/GATA2/PAF1/HOXA5/HIF1A/TSPAN2/BMP4/IRF8/NFE2L1/HDAC1/JMJD6/NCKAP1L/LBR/PF4/TLR2/IKZF1/STAT1/CTNNBIP1/LILRB3/IRF7/APCS/INPP5D/TFRC/CNOT4/SFRP1/PTPN2/CUL4A/TRIM58/IL15/JUN 52 BP GO:0001909 leukocyte mediated cytotoxicity 22/1096 107/18670 2.123e-07 8.694e-06 5.897e-06 IL7R/CORO1A/GZMB/RASGRP1/ICAM1/CD226/EMP2/SH2D1A/FCGR2B/PTPN6/RAB27A/CTSC/PTPRC/CRTAM/DNASE1L3/HPRT1/STXBP2/CTSH/CXCL6/LAG3/VAV1/ELANE 22 BP GO:0050707 regulation of cytokine secretion 33/1096 210/18670 2.163e-07 8.779e-06 5.954e-06 FCN1/TNFAIP3/TNFRSF1B/IL4R/LPL/SRGN/ANGPT1/CD200/RASGRP1/GATA3/AIM2/FCGR2B/IL1B/POSTN/CD2/CCR7/XBP1/MAPK3/IL27RA/SPTBN1/CRTAM/CD14/LILRA2/GAS6/PTPN22/F2R/TNFRSF4/IL17RA/TLR2/GBP1/TWIST1/NLRP3/GLMN 33 BP GO:0051047 positive regulation of secretion 53/1096 428/18670 2.175e-07 8.779e-06 5.954e-06 SPP1/FCN1/IL4R/LPL/ADAM8/TGFB2/STXBP1/EGFR/RASGRP1/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/SDC1/RBP4/XBP1/MAPK3/ADORA1/GAB2/RAB27A/PTAFR/SPTBN1/NMB/CD38/MYH10/CRTAM/CD14/LILRA2/ABCG1/OXCT1/FGFR1/GATA2/PTPN22/HIF1A/F2R/PINK1/UNC13B/TNFRSF4/TTN/AQP1/IL17RA/BAD/TLR2/CXCL12/TWIST1/NLRP3/ITGB2/MYOM1/INHBB/NNAT/GLMN 53 BP GO:0002691 regulation of cellular extravasation 11/1096 28/18670 2.309e-07 9.254e-06 6.277e-06 PLCB1/ADAM8/ICAM1/IL27RA/PTAFR/ITGA4/CCR2/THY1/CXCL12/ABR/ELANE 11 BP GO:0070371 ERK1 and ERK2 cascade 43/1096 317/18670 2.539e-07 1.01e-05 6.853e-06 CCL5/ANGPT1/CCL13/P2RY6/ITGAV/EGFR/ADIPOQ/RASGRP1/ICAM1/PTK2B/IL1B/CCL18/SLAMF1/CCR7/MAPK3/PTPN6/GPR183/CHI3L1/CD44/PTPRC/MFHAS1/GAS6/CTSH/PTPN22/PIN1/RAPGEF1/F2R/BMP4/PHB/TIMP3/GBP1/APOE/LMO3/CSK/DUSP3/PTPN2/FGFR3/CCL2/PDGFRA/SPRY1/CCL7/FLT1/JUN 43 BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 28/1096 163/18670 2.752e-07 1.088e-05 7.377e-06 TNFAIP3/ZBTB20/LPL/ADAM8/ANGPT1/ADIPOQ/AXL/RASGRP1/SLAMF1/CD2/HSPB1/PTPN6/IL27RA/PTAFR/PTPRC/LY96/CD14/LILRA2/CX3CR1/GAS6/CCR2/PTPN22/PF4/UBE2J1/TLR2/CD86/LBP/TWIST1 28 BP GO:0055002 striated muscle cell development 29/1096 173/18670 2.9e-07 1.138e-05 7.72e-06 TMOD1/VEGFA/SORBS2/SIX1/PAK1/SDC1/TNNT1/MYL2/LDB3/MYH11/RGS2/MYH10/CASQ2/CSRP1/MYOM2/CAV3/PIN1/UCHL1/ACTA1/BMP4/GPX1/CCNB1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/PDGFRA/MYOM1 29 BP GO:0050673 epithelial cell proliferation 53/1096 434/18670 3.392e-07 1.322e-05 8.968e-06 RUNX3/TNFAIP3/TGFBR3/CCL5/LOXL2/SEMA5A/TGFA/TGFB2/VEGFA/EGFR/SIX1/NFIB/AKT3/GATA3/NUPR1/TCF7L2/SMAD3/SULF1/BCL2L2/XBP1/RGN/CCND1/MAGED1/ITGA4/ID1/EGR3/AR/FGFR1/GATA2/HOXA5/HIF1A/BMP4/GPX1/FZD7/PURA/IGFBP5/BAD/HTRA1/STAT1/APOE/BMPR1A/CXCL12/TWIST1/THBS4/AGTR1/SFRP1/NRP2/CCL2/OSR2/NRAS/HYAL1/FLT1/JUN 53 BP GO:1901655 cellular response to ketone 20/1096 93/18670 3.497e-07 1.348e-05 9.146e-06 SPP1/FOXO1/P2RY6/EGFR/PCK1/ICAM1/AKR1B1/ASS1/AR/ADCY6/EFNA5/MAP4K1/CDK4/AQP1/DDIT4/PTGER2/TFAP4/SFRP1/PCK2/ADCY1 20 BP GO:0006874 cellular calcium ion homeostasis 55/1096 458/18670 3.527e-07 1.348e-05 9.146e-06 PLCB1/CXCR4/CCL5/CXCL13/CORO1A/CCL13/P2RY6/ITGAV/LCK/PRKCB/PTK2B/CALB2/CD40/STC1/SMAD3/CCR7/S1PR1/ADORA1/PLN/PTPN6/RGN/TGM2/NOL3/CCR5/NMB/CD38/PTPRC/CDH5/CASQ2/PLCG2/CX3CR1/GATA2/CCR2/CAV3/F2R/THY1/CXCR6/GOT1/ATP2A1/CCR6/APOE/CXCL10/CXCL12/AGTR1/PTGER2/C3AR1/ATP13A3/PDGFRA/BNIP3/WFS1/S1PR4/CD52/ELANE/CCL7/HERPUD1 55 BP GO:0001101 response to acid chemical 45/1096 343/18670 3.53e-07 1.348e-05 9.146e-06 FOXO1/TGFBR3/LPL/P2RY6/VEGFA/GSN/EPHA3/EGFR/ADIPOQ/SIX1/PCK1/ICAM1/NTRK3/PTK2B/AKR1B1/EEF2/CCR7/IGFBP7/RBP4/XBP1/ID3/ASS1/PTAFR/CD38/COL1A1/ADCY6/CDO1/CTSH/PINK1/IGFBP2/NQO1/CDK4/FZD7/CCNB1/AQP1/BAD/MAPK10/TLR2/GLRB/PTGER2/SFRP1/PDGFRA/COL3A1/RXRA/COL4A1 45 BP GO:0070372 regulation of ERK1 and ERK2 cascade 41/1096 300/18670 3.929e-07 1.491e-05 1.011e-05 CCL5/ANGPT1/CCL13/P2RY6/EGFR/ADIPOQ/RASGRP1/ICAM1/PTK2B/IL1B/CCL18/SLAMF1/CCR7/MAPK3/PTPN6/GPR183/CHI3L1/CD44/PTPRC/MFHAS1/GAS6/PTPN22/PIN1/RAPGEF1/F2R/BMP4/PHB/TIMP3/GBP1/APOE/LMO3/CSK/DUSP3/PTPN2/FGFR3/CCL2/PDGFRA/SPRY1/CCL7/FLT1/JUN 41 BP GO:0050714 positive regulation of protein secretion 38/1096 268/18670 4.085e-07 1.539e-05 1.044e-05 FCN1/IL4R/LPL/ADAM8/TGFB2/EGFR/RASGRP1/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/RBP4/XBP1/MAPK3/SPTBN1/CD38/MYH10/CRTAM/CD14/LILRA2/ABCG1/OXCT1/PTPN22/HIF1A/F2R/UNC13B/TNFRSF4/TTN/IL17RA/BAD/TLR2/TWIST1/NLRP3/MYOM1/NNAT/GLMN 38 BP GO:0051897 positive regulation of protein kinase B signaling 29/1096 176/18670 4.214e-07 1.578e-05 1.07e-05 ADAM8/RAC2/ANGPT1/SEMA5A/TGFA/EGFR/AXL/LCK/HBEGF/GATA3/CPNE1/TCF7L2/CCR7/BTC/CHI3L1/MFHAS1/INSR/HCLS1/CX3CR1/FGFR1/GAS6/PINK1/GPX1/IGFBP5/HIP1/CD86/VAV1/FGFR3/PDGFRA 29 BP GO:0050679 positive regulation of epithelial cell proliferation 32/1096 206/18670 4.294e-07 1.59e-05 1.078e-05 TNFAIP3/CCL5/SEMA5A/TGFA/VEGFA/EGFR/AKT3/TCF7L2/XBP1/CCND1/ITGA4/ID1/EGR3/AR/FGFR1/GATA2/HIF1A/BMP4/FZD7/BAD/HTRA1/BMPR1A/CXCL12/TWIST1/THBS4/AGTR1/SFRP1/NRP2/OSR2/NRAS/HYAL1/JUN 32 BP GO:0055001 muscle cell development 30/1096 186/18670 4.302e-07 1.59e-05 1.078e-05 TMOD1/VEGFA/SORBS2/SIX1/BIN1/PAK1/SDC1/TNNT1/MYL2/LDB3/MYH11/RGS2/MYH10/CASQ2/CSRP1/MYOM2/CAV3/PIN1/UCHL1/ACTA1/BMP4/GPX1/CCNB1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/PDGFRA/MYOM1 30 BP GO:0090257 regulation of muscle system process 37/1096 259/18670 4.795e-07 1.76e-05 1.194e-05 FOXO1/TNFRSF1B/SGCA/ADA/BIN1/STC1/DAG1/SMAD3/PAK1/ADORA1/PLN/TNNT1/MYL2/PTAFR/NOL3/RGS2/CASQ2/TNNC2/MYL9/MYH7/TNNC1/CAV3/MYL3/AKAP9/PIN1/F2R/TNNI1/ATP2A1/HSPB6/IGFBP5/PRKG1/KCNB2/PDE9A/HDAC4/CTTN/JARID2/CHRM3 37 BP GO:0055006 cardiac cell development 20/1096 95/18670 5.03e-07 1.835e-05 1.245e-05 TGFBR3/VEGFA/SORBS2/PAK1/MYL2/MYH11/RGS2/MYH10/MYOM2/CAV3/PIN1/BMP4/CCNB1/TTN/MYBPC2/NEB/PDLIM5/PDGFRA/SPRY1/MYOM1 20 BP GO:0071706 tumor necrosis factor superfamily cytokine production 28/1096 168/18670 5.224e-07 1.894e-05 1.284e-05 TNFAIP3/ZBTB20/LPL/ADAM8/ANGPT1/ADIPOQ/AXL/RASGRP1/SLAMF1/CD2/HSPB1/PTPN6/IL27RA/PTAFR/PTPRC/LY96/CD14/LILRA2/CX3CR1/GAS6/CCR2/PTPN22/PF4/UBE2J1/TLR2/CD86/LBP/TWIST1 28 BP GO:0070997 neuron death 45/1096 348/18670 5.33e-07 1.92e-05 1.302e-05 TRIM2/TNFRSF1B/CCL5/ADAM8/MECP2/ANGPT1/CORO1A/TGFB2/STXBP1/TOX3/CD200/AXL/SIX1/GATA3/PTK2B/FCGR2B/NUPR1/NAMPT/DAXX/ADORA1/BTG2/HSPA5/RAB29/CX3CR1/PIN1/HIF1A/F2R/PINK1/NQO1/NTF3/DIO3/BAD/APOE/NGF/HDAC4/DDIT4/LGMN/ITGB2/CCL2/BNIP3/WFS1/IKBKG/TYRO3/CRLF1/JUN 45 BP GO:0050866 negative regulation of cell activation 31/1096 199/18670 6.083e-07 2.177e-05 1.477e-05 RUNX3/TNFAIP3/IL4R/SERPINE2/CD200/AXL/LILRB2/IRF1/FCGR2B/PTPN6/PTPRC/CST7/DLG5/CCR2/PTPN22/BMP4/PARP3/LAG3/PRKG1/APOE/CD86/ABR/INPP5D/SFRP1/DUSP3/PTPN2/IL2RA/PDGFRA/PRDX2/TYRO3/GLMN 31 BP GO:0048644 muscle organ morphogenesis 19/1096 88/18670 6.404e-07 2.278e-05 1.545e-05 TGFBR3/TGFB2/S1PR1/FZD2/MYL2/MYOM2/MYH7/TNNC1/MYL3/TNNI1/TTN/MYBPC2/UBE4B/BMPR1A/FOXC1/COL3A1/MYOM1/RXRA/TCF15 19 BP GO:0072593 reactive oxygen species metabolic process 39/1096 284/18670 6.636e-07 2.346e-05 1.591e-05 FOXO1/RAC2/CRYAB/HBB/GCHFR/EGFR/PXDN/ICAM1/GPX3/PTK2B/IL1B/SMAD3/HK2/GCH1/RGN/ASS1/FBLN5/RAB27A/INSR/TRAP1/CX3CR1/HIF1A/PINK1/GPX1/NQO1/ZNF205/FANCC/TLR2/HDAC4/LPO/DDIT4/AGTR1/VAV1/ITGB2/NCF2/BNIP3/PRDX2/HBE1/SLC18A2 39 BP GO:0050901 leukocyte tethering or rolling 10/1096 25/18670 6.779e-07 2.382e-05 1.615e-05 ITGB7/SELPLG/PTAFR/ITGA4/CX3CR1/CCR2/SELL/CXCL12/SELP/ELANE 10 BP GO:0072678 T cell migration 16/1096 65/18670 7.549e-07 2.636e-05 1.788e-05 CCL5/ADAM8/ITGB7/CXCL13/CD200/ICAM1/S1PR1/GPR183/IL27RA/ITGA4/CCR2/CCR6/CXCL10/CXCL12/TNFSF14/CCL2 16 BP GO:0002703 regulation of leukocyte mediated immunity 31/1096 201/18670 7.6e-07 2.637e-05 1.789e-05 TNFRSF1B/IL4R/RAC2/IL7R/STXBP1/RASGRP1/CD226/GATA3/SH2D1A/CD40/FCGR2B/IL1B/TP53BP1/PTPN6/IL27RA/GAB2/PTAFR/PTPRC/CRTAM/DNASE1L3/GATA2/STXBP2/CCR2/CXCL6/PARP3/LAG3/ABR/NLRP3/VAV1/TFRC/ITGB2 31 BP GO:0048015 phosphatidylinositol-mediated signaling 29/1096 181/18670 7.685e-07 2.644e-05 1.793e-05 PLCB1/SERPINE2/CCL5/ANGPT1/TGFB2/GSN/EGFR/RASGRP1/PTPN13/GATA3/NTRK3/PIP4K2B/MAPK3/PTPN6/GAB2/PTAFR/INSR/PLCG2/HCLS1/FGFR1/INPP5F/F2R/NTF3/NGF/TWIST1/PDGFRA/TYRO3/SELP/FLT1 29 BP GO:0006066 alcohol metabolic process 46/1096 364/18670 7.713e-07 2.644e-05 1.793e-05 PLCB1/MECP2/P2RY6/ADH1B/CH25H/PCK1/PTK2B/IL1B/AKR1B1/PLEK/SLC5A3/RBP4/ADH1A/GCH1/GK/CYB5R3/HDLBP/ADH1C/NFKB1/PTAFR/LIPC/NPC1/ABCG1/PLCG2/FGFR1/PNPLA4/APOC1/ALDH3B1/PCBD1/AKR7A2/GOT1/MOXD1/MINPP1/NFE2L1/LBR/AKR1B10/PMVK/DHRS3/APOE/QDPR/APOF/INPP5D/ALDH3A2/RXRA/PCK2/NUDT3 46 BP GO:0031960 response to corticosteroid 27/1096 162/18670 8.3e-07 2.824e-05 1.915e-05 FOXO1/EGFR/ADIPOQ/IL1RN/PCK1/ICAM1/NTRK3/STC1/CSN1S1/IGFBP7/SDC1/ABCA3/PAM/ASS1/PTAFR/CCND1/ALPL/COL1A1/CDO1/GOT1/IGFBP2/AQP1/BAD/HSD11B2/DDIT4/TFAP4/PCK2 27 BP GO:0032102 negative regulation of response to external stimulus 46/1096 365/18670 8.337e-07 2.824e-05 1.915e-05 SPP1/TNFAIP3/TNFRSF1B/SERPINE2/CXCL13/SEMA5A/TNFAIP6/SEMA3E/CD200/ADIPOQ/SEMA3A/ADA/GATA3/FCGR2B/SMAD3/ADORA1/NFKB1/PTPRC/CDH5/MFHAS1/LILRA2/CST7/TFPI/INPP5F/SEMA3C/SEMA4F/GPX1/PLAUR/MAPK7/PCBP2/HTRA1/PRKG1/APOE/SERPINE1/ABR/NLRP3/APCS/DUSP3/PTPN2/ANGPT2/CCL2/IL2RA/PDGFRA/PRDX2/TYRO3/ELANE 46 BP GO:0031663 lipopolysaccharide-mediated signaling pathway 15/1096 58/18670 8.423e-07 2.836e-05 1.924e-05 TNFAIP3/CCL5/IL1B/MAPK3/NFKBIA/PTAFR/LY96/CD14/LILRA2/SASH1/PTPN22/TLR2/LBP/CCL2/PRDX2 15 BP GO:0050852 T cell receptor signaling pathway 31/1096 202/18670 8.483e-07 2.84e-05 1.926e-05 CD247/TRBC1/CD3D/ITK/LCK/CD226/ADA/GATA3/RFTN1/CCR7/PAK1/LILRB4/PTPN6/NFKB1/PTPRC/LCP2/RAB29/PLCG2/THEMIS2/PAK2/CD3G/SKAP1/PTPN22/THY1/GBP1/CSK/INPP5D/DUSP3/PTPN2/IKBKG/LAT 31 BP GO:0055074 calcium ion homeostasis 55/1096 471/18670 8.639e-07 2.875e-05 1.95e-05 PLCB1/CXCR4/CCL5/CXCL13/CORO1A/CCL13/P2RY6/ITGAV/LCK/PRKCB/PTK2B/CALB2/CD40/STC1/SMAD3/CCR7/S1PR1/ADORA1/PLN/PTPN6/RGN/TGM2/NOL3/CCR5/NMB/CD38/PTPRC/CDH5/CASQ2/PLCG2/CX3CR1/GATA2/CCR2/CAV3/F2R/THY1/CXCR6/GOT1/ATP2A1/CCR6/APOE/CXCL10/CXCL12/AGTR1/PTGER2/C3AR1/ATP13A3/PDGFRA/BNIP3/WFS1/S1PR4/CD52/ELANE/CCL7/HERPUD1 55 BP GO:0051896 regulation of protein kinase B signaling 35/1096 244/18670 8.812e-07 2.916e-05 1.978e-05 MAGI2/ADAM8/RAC2/ANGPT1/SEMA5A/TGFA/EGFR/AXL/PHLPP1/LCK/HBEGF/GATA3/CPNE1/DAG1/TCF7L2/CCR7/BTC/CHI3L1/MFHAS1/INSR/HCLS1/CX3CR1/FGFR1/GAS6/INPP5F/CAV3/RAPGEF1/PINK1/GPX1/IGFBP5/HIP1/CD86/VAV1/FGFR3/PDGFRA 35 BP GO:0002793 positive regulation of peptide secretion 39/1096 288/18670 9.492e-07 3.122e-05 2.118e-05 FCN1/IL4R/LPL/ADAM8/TGFB2/EGFR/RASGRP1/GATA3/AIM2/TCF7L2/IL1B/POSTN/CD2/RBP4/XBP1/MAPK3/ADORA1/SPTBN1/CD38/MYH10/CRTAM/CD14/LILRA2/ABCG1/OXCT1/PTPN22/HIF1A/F2R/UNC13B/TNFRSF4/TTN/IL17RA/BAD/TLR2/TWIST1/NLRP3/MYOM1/NNAT/GLMN 39 BP GO:0060415 muscle tissue morphogenesis 18/1096 82/18670 9.713e-07 3.177e-05 2.155e-05 TGFBR3/TGFB2/S1PR1/FZD2/MYL2/MYOM2/MYH7/TNNC1/MYL3/TNNI1/TTN/MYBPC2/UBE4B/BMPR1A/FOXC1/COL3A1/MYOM1/RXRA 18 BP GO:0060560 developmental growth involved in morphogenesis 34/1096 235/18670 1.03e-06 3.349e-05 2.272e-05 SPP1/CXCR4/MAGI2/SEMA5A/VEGFA/SEMA3E/SEMA3A/SIX1/NTRK3/DCLK1/CPNE1/POSTN/AUTS2/PAK1/S1PR1/NEDD4L/ITGA4/OLFM1/SYT17/SEMA3C/SEMA4F/BMP4/EFNA5/APOE/NGF/CTTN/CXCL12/LAMB2/SFRP1/NRP2/COBL/SPRY1/DPYSL2/CYFIP2 34 BP GO:0048017 inositol lipid-mediated signaling 29/1096 184/18670 1.088e-06 3.519e-05 2.387e-05 PLCB1/SERPINE2/CCL5/ANGPT1/TGFB2/GSN/EGFR/RASGRP1/PTPN13/GATA3/NTRK3/PIP4K2B/MAPK3/PTPN6/GAB2/PTAFR/INSR/PLCG2/HCLS1/FGFR1/INPP5F/F2R/NTF3/NGF/TWIST1/PDGFRA/TYRO3/SELP/FLT1 29 BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 32/1096 215/18670 1.133e-06 3.643e-05 2.471e-05 CRYAB/VEGFA/GSN/TNFRSF10B/LCK/BIRC3/SMAD3/CTSD/DAP/S100A9/NOL3/TNFSF10/CD44/PAK2/CD27/GAS6/CTSH/CASP4/F2R/LAMP3/DLC1/GPX1/PLAUR/AQP1/HIP1/BAD/GRAMD4/NGF/NLRP3/TNFSF14/TFAP4/HERPUD1 32 BP GO:0097237 cellular response to toxic substance 35/1096 247/18670 1.178e-06 3.766e-05 2.554e-05 FOXO1/TNFAIP3/LTC4S/HBB/PTGS1/AXL/PXDN/ADIRF/GPX3/PCGF2/GPX4/DAXX/ABTB2/GCH1/RGN/S100A9/FBLN5/NFKB1/TRAP1/PINK1/GPX1/NQO1/MAPK7/AQP1/AKR1B10/BAD/FANCC/APOE/MAPK13/LPO/GSTT1/BNIP3/PRDX2/CCL7/HBE1 35 BP GO:1901214 regulation of neuron death 41/1096 313/18670 1.209e-06 3.845e-05 2.608e-05 TRIM2/TNFRSF1B/CCL5/ADAM8/MECP2/ANGPT1/CORO1A/TGFB2/STXBP1/TOX3/CD200/AXL/SIX1/GATA3/PTK2B/FCGR2B/NUPR1/DAXX/ADORA1/BTG2/RAB29/CX3CR1/PIN1/HIF1A/F2R/PINK1/NQO1/NTF3/BAD/APOE/NGF/HDAC4/DDIT4/LGMN/ITGB2/CCL2/WFS1/IKBKG/TYRO3/CRLF1/JUN 41 BP GO:0048638 regulation of developmental growth 44/1096 347/18670 1.218e-06 3.852e-05 2.612e-05 SPP1/PLCB1/TGFBR3/CXCR4/FTO/SEMA5A/VEGFA/SEMA3E/SEMA3A/SIX1/NTRK3/PAK1/RBP4/NEDD4L/RGS2/INSR/AR/FGFR1/OLFM1/SYT17/CAV3/SEMA3C/PIN1/SEMA4F/BMP4/PIM1/EFNA5/CDK4/DIO3/CCNB1/BASP1/APOE/NGF/PHLDA2/CTTN/BMPR1A/JARID2/CXCL12/FOXC1/CARM1/LGMN/SFRP1/FGFR3/DPYSL2 44 BP GO:0051384 response to glucocorticoid 25/1096 146/18670 1.256e-06 3.93e-05 2.666e-05 FOXO1/EGFR/ADIPOQ/IL1RN/PCK1/ICAM1/NTRK3/STC1/IGFBP7/SDC1/ABCA3/PAM/ASS1/PTAFR/CCND1/ALPL/CDO1/GOT1/IGFBP2/AQP1/BAD/HSD11B2/DDIT4/TFAP4/PCK2 25 BP GO:0002699 positive regulation of immune effector process 32/1096 216/18670 1.257e-06 3.93e-05 2.666e-05 IL4R/RAC2/STXBP1/RASGRP1/CD226/GATA3/SH2D1A/CD40/IL1B/TP53BP1/RBP4/XBP1/MAPK3/GAB2/PTAFR/PTPRC/CRTAM/GATA2/STXBP2/CCR2/RAPGEF1/TNFRSF4/PHB/LAG3/HLA-DMB/C6/CD86/LBP/NLRP3/VAV1/TFRC/ITGB2 32 BP GO:0070482 response to oxygen levels 48/1096 394/18670 1.295e-06 4.029e-05 2.733e-05 FOXO1/TGFBR3/CXCR4/ADAM8/MECP2/LOXL2/CRYAB/TGFB2/VEGFA/PDLIM1/ADIPOQ/NDRG1/PCK1/ICAM1/ADA/PTK2B/STC1/NAMPT/POSTN/SMAD3/HK2/PAK1/ADORA1/PAM/NOL3/CD38/TM9SF4/COL1A1/MB/UCP2/PIN1/HIF1A/PINK1/CCNA2/CDK4/CCNB1/AQP1/AHCY/BAD/TLR2/HSD11B2/DDIT4/CXCL12/TWIST1/SFRP1/ANGPT2/BNIP3/ATP6V0D1 48 BP GO:0030100 regulation of endocytosis 38/1096 281/18670 1.349e-06 4.173e-05 2.83e-05 MAGI2/IL15RA/IL2RG/ANGPT1/IL2RB/VEGFA/ITGAV/EPHA3/ADIPOQ/AXL/BIN1/FCGR2B/IL1B/NEDD4L/SFRP4/RAB27A/PTPRC/CD14/PLCG2/DNM1/GAS6/GATA2/APOC1/CAV3/RAPGEF1/NTF3/NCKAP1L/HIP1/TLR2/USP46/APOE/SERPINE1/SNAP91/CSK/ABR/CCL2/PPP3CC/IL15 38 BP GO:0031532 actin cytoskeleton reorganization 20/1096 101/18670 1.404e-06 4.301e-05 2.917e-05 PARVA/SIPA1L1/GSN/SEMA3E/NTRK3/CDC42BPA/PTK2B/PLEK/AUTS2/PAK1/S1PR1/RALA/HCLS1/ARHGDIB/PDLIM4/NTF3/GMFG/RHOBTB1/CTTN/PDGFRA 20 BP GO:0050856 regulation of T cell receptor signaling pathway 12/1096 39/18670 1.406e-06 4.301e-05 2.917e-05 LCK/CD226/ADA/CCR7/LILRB4/PTPN6/RAB29/PTPN22/THY1/GBP1/DUSP3/PTPN2 12 BP GO:0033627 cell adhesion mediated by integrin 16/1096 68/18670 1.449e-06 4.411e-05 2.992e-05 CCL5/ITGB7/CXCL13/TGFB2/ITGAV/ICAM1/ADA/PTPN6/ITGA4/ITGBL1/SKAP1/ITGA5/NCKAP1L/SERPINE1/LPXN/ITGB2 16 BP GO:0046651 lymphocyte proliferation 37/1096 272/18670 1.606e-06 4.857e-05 3.295e-05 TNFRSF1B/CCL5/RAC2/IL7R/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/HPRT1/DLG5/CCR2/PTPN22/BMP4/IGFBP2/ELF4/TNFRSF4/PURA/NCKAP1L/SATB1/HLA-DMB/CD86/INPP5D/TFRC/TNFSF14/IL2RA/IMPDH1/IMPDH2/PRDX2/IL15/GLMN 37 BP GO:0003206 cardiac chamber morphogenesis 23/1096 129/18670 1.613e-06 4.857e-05 3.295e-05 TGFBR3/PARVA/TGFB2/GATA3/RBP4/FZD2/MYL2/MYH7/TNNC1/CAV3/SEMA3C/MYL3/SMARCD3/HIF1A/BMP4/TNNI1/UBE4B/DHRS3/BMPR1A/FOXC1/NRP2/SMAD6/RXRA 23 BP GO:0019058 viral life cycle 42/1096 328/18670 1.64e-06 4.911e-05 3.331e-05 FCN1/CXCR4/CCL5/HTATSF1/ITGB7/GSN/ITGAV/EGFR/AXL/ICAM1/SLPI/DAG1/SLAMF1/NEDD4L/SELPLG/CXCL8/CCR5/NPC1/MID2/RAB29/PLSCR1/ISG20/PC/HAVCR1/GAS6/SLC20A2/CXCR6/LAMP3/ITGA5/NFIA/TNFRSF4/PCBP2/APOE/CD86/APCS/TFRC/CCL2/NUP210/TYRO3/SIVA1/VAPA/HYAL1 42 BP GO:0001503 ossification 48/1096 398/18670 1.729e-06 5.15e-05 3.493e-05 SPP1/ZBTB16/DDR2/XYLT1/SRGN/EGR2/WWTR1/TGFB2/EGFR/ZHX3/ENPP1/THRA/PTK2B/STC1/SMAD3/TPM4/S1PR1/MGP/MAPK3/NELL1/KAZALD1/ID3/MN1/ALPL/PTHLH/SMAD1/ID1/COL1A1/HIF1A/ID4/BMP4/MINPP1/LRP5/PHB/IGFBP5/SND1/DHRS3/FBL/CTNNBIP1/GDF10/HDAC4/BMPR1A/TWIST1/FOXC1/SFRP1/FGFR3/OSR2/SMAD6 48 BP GO:0055008 cardiac muscle tissue morphogenesis 16/1096 69/18670 1.785e-06 5.291e-05 3.589e-05 TGFBR3/TGFB2/S1PR1/MYL2/MYOM2/MYH7/TNNC1/MYL3/TNNI1/TTN/MYBPC2/UBE4B/BMPR1A/FOXC1/MYOM1/RXRA 16 BP GO:0031032 actomyosin structure organization 30/1096 199/18670 1.855e-06 5.469e-05 3.709e-05 TMOD1/EPB41L1/EPB41L2/CDC42BPA/ARHGEF10/PTK2B/SMAD3/PAK1/S1PR1/TNNT1/MYL2/LDB3/MYH11/MYH10/CASQ2/CSRP1/FAM171A1/MYOM2/TNFAIP1/CAV3/ACTA1/DLC1/TTN/MYBPC2/NEB/ARHGEF5/SFRP1/PDGFRA/PFN2/MYOM1 30 BP GO:0001818 negative regulation of cytokine production 39/1096 296/18670 1.893e-06 5.552e-05 3.766e-05 TNFAIP3/SRGN/ANGPT1/RELB/TGFB2/CD200/ADIPOQ/AXL/GATA3/FCGR2B/SLAMF1/PTPN6/IL27RA/NFKB1/PTPRC/TRIB2/CD83/CX3CR1/FGFR1/GAS6/PTPN22/PIN1/NMI/HOMER3/TNFRSF4/PCBP2/NCKAP1L/LAG3/GBP1/KAT5/LBP/CSK/TWIST1/NLRP3/INPP5D/ASB1/IKBKE/ELANE/INHBB 39 BP GO:0032943 mononuclear cell proliferation 37/1096 274/18670 1.918e-06 5.596e-05 3.796e-05 TNFRSF1B/CCL5/RAC2/IL7R/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/HPRT1/DLG5/CCR2/PTPN22/BMP4/IGFBP2/ELF4/TNFRSF4/PURA/NCKAP1L/SATB1/HLA-DMB/CD86/INPP5D/TFRC/TNFSF14/IL2RA/IMPDH1/IMPDH2/PRDX2/IL15/GLMN 37 BP GO:2000107 negative regulation of leukocyte apoptotic process 13/1096 47/18670 1.982e-06 5.756e-05 3.904e-05 CCL5/IL7R/AXL/ADA/CCR7/CCR5/CD27/HCLS1/GAS6/HIF1A/BMP4/IRF7/CXCL12 13 BP GO:0032680 regulation of tumor necrosis factor production 26/1096 160/18670 2.155e-06 6.226e-05 4.223e-05 TNFAIP3/ZBTB20/LPL/ANGPT1/ADIPOQ/AXL/RASGRP1/SLAMF1/CD2/HSPB1/PTPN6/IL27RA/PTAFR/PTPRC/LY96/CD14/LILRA2/CX3CR1/GAS6/CCR2/PTPN22/PF4/UBE2J1/TLR2/LBP/TWIST1 26 BP GO:0032956 regulation of actin cytoskeleton organization 43/1096 343/18670 2.172e-06 6.243e-05 4.234e-05 TMOD1/CORO1A/SEMA5A/RHOH/GSN/EPHA3/SEMA3E/ICAM1/CDK10/NTRK3/BIN1/ARHGEF10/PTK2B/RHOBTB3/PLEK/SMAD3/CCR7/PAK1/S1PR1/PAM/SPTBN1/ID1/HCLS1/ARHGDIB/CAPG/KANK1/CAV3/DLC1/EFNA5/NTF3/GMFG/NCKAP1/NCKAP1L/RHOBTB1/NEB/CTTN/ARPC3/CXCL12/ARHGEF5/SFRP1/TENM1/PDGFRA/PFN2 43 BP GO:0043500 muscle adaptation 22/1096 122/18670 2.222e-06 6.353e-05 4.309e-05 FOXO1/TNFRSF1B/GSN/IL1B/SMAD3/PAK1/TNNT1/NOL3/RGS2/MYH7/INPP5F/TNNC1/CAV3/PIN1/ACTA1/TNNI1/IGFBP5/PDE9A/HDAC4/CAMTA2/JARID2/IL15 22 BP GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 12/1096 41/18670 2.545e-06 7.242e-05 4.912e-05 TGFB2/NFIB/SMAD3/LILRB4/SMAD1/GATA2/HIF1A/BMP4/HDAC4/BMPR1A/SMAD6/JUN 12 BP GO:0042089 cytokine biosynthetic process 22/1096 123/18670 2.558e-06 7.242e-05 4.912e-05 IRF1/GATA3/IL1B/HSPB1/NFKB1/PTAFR/PTPRC/TRIB2/CX3CR1/CCR2/NMI/LAG3/UBE2J1/IRF7/CD86/LBP/IGF2BP3/INPP5D/ASB1/ELANE/INHBB/GLMN 22 BP GO:2000401 regulation of lymphocyte migration 15/1096 63/18670 2.622e-06 7.317e-05 4.963e-05 CCL5/ADAM8/CXCL13/CD200/PTK2B/IL27RA/ITGA4/CCR2/STK10/CCR6/CXCL10/CXCL12/TNFSF14/CCL2/CCL7 15 BP GO:0048588 developmental cell growth 33/1096 234/18670 2.625e-06 7.317e-05 4.963e-05 SPP1/CXCR4/SEMA5A/VEGFA/SORBS2/SEMA3E/SEMA3A/NTRK3/DCLK1/CPNE1/POSTN/AUTS2/PAK1/NEDD4L/RGS2/ITGA4/OLFM1/SYT17/CAV3/SEMA3C/PIN1/SEMA4F/EFNA5/APOE/NGF/CTTN/PDLIM5/CXCL12/LAMB2/NRP2/COBL/DPYSL2/CYFIP2 33 BP GO:0071902 positive regulation of protein serine/threonine kinase activity 42/1096 334/18670 2.628e-06 7.317e-05 4.963e-05 CXCR4/ADAM8/TGFA/VEGFA/EGFR/ADIPOQ/RASGRP1/DUSP5/NTRK3/PTK2B/CD40/IL1B/PAK1/DAXX/MAPK3/ADORA1/CCND2/MAPRE3/MAP3K4/CKS1B/CCND1/PTPRC/MAGED1/INSR/FGFR1/SASH1/RAPGEF1/F2R/BMP4/MAP4K1/NTF3/CCNB1/MAPK10/NGF/CSK/ARHGEF5/TENM1/IKBKG/PRDX2/ELANE/CDC6/FLT1 42 BP GO:0042035 regulation of cytokine biosynthetic process 21/1096 114/18670 2.636e-06 7.317e-05 4.963e-05 IRF1/GATA3/IL1B/HSPB1/NFKB1/PTAFR/PTPRC/TRIB2/CX3CR1/CCR2/NMI/LAG3/UBE2J1/CD86/LBP/IGF2BP3/INPP5D/ASB1/ELANE/INHBB/GLMN 21 BP GO:0060485 mesenchyme development 37/1096 278/18670 2.714e-06 7.499e-05 5.086e-05 TGFBR3/LOXL2/SEMA5A/WWTR1/TGFB2/EPHA3/SEMA3E/SEMA3A/SIX1/DAG1/IL1B/MEOX1/SMAD3/FAM172A/MAPK3/PDPN/COL1A1/FGFR1/DLG5/OLFM1/SEMA3C/ACTA2/HOXA5/HIF1A/SEMA4F/LDLRAD4/ACTA1/BMP4/BASP1/STAT1/BMPR1A/TWIST1/FOXC1/SFRP1/NRP2/SPRY1/TCF15 37 BP GO:1904035 regulation of epithelial cell apoptotic process 18/1096 88/18670 2.873e-06 7.899e-05 5.358e-05 TNFAIP3/ANGPT1/SEMA5A/GSN/ICAM1/GATA3/CD40/NUPR1/TCF7L2/SFRP4/ITGA4/GAS6/GATA2/MAPK7/BAD/SERPINE1/CCL2/WFS1 18 BP GO:0042107 cytokine metabolic process 22/1096 124/18670 2.94e-06 8.043e-05 5.455e-05 IRF1/GATA3/IL1B/HSPB1/NFKB1/PTAFR/PTPRC/TRIB2/CX3CR1/CCR2/NMI/LAG3/UBE2J1/IRF7/CD86/LBP/IGF2BP3/INPP5D/ASB1/ELANE/INHBB/GLMN 22 BP GO:0032640 tumor necrosis factor production 26/1096 163/18670 3.076e-06 8.362e-05 5.672e-05 TNFAIP3/ZBTB20/LPL/ANGPT1/ADIPOQ/AXL/RASGRP1/SLAMF1/CD2/HSPB1/PTPN6/IL27RA/PTAFR/PTPRC/LY96/CD14/LILRA2/CX3CR1/GAS6/CCR2/PTPN22/PF4/UBE2J1/TLR2/LBP/TWIST1 26 BP GO:0007160 cell-matrix adhesion 32/1096 225/18670 3.086e-06 8.362e-05 5.672e-05 DDR2/ITGB7/VEGFA/ITGAV/EPHA3/SEMA3E/EMP2/PTK2B/DAG1/TMEM8B/ACTN1/POSTN/SMAD3/CCR7/ITGAL/FBLN5/CD44/ITGA4/ITGBL1/SKAP1/THY1/DLC1/EFNA5/PECAM1/NINJ1/SERPINE1/SNED1/CTTN/SFRP1/ITGB2/DUSP3/COL3A1 32 BP GO:0043087 regulation of GTPase activity 54/1096 479/18670 3.173e-06 8.557e-05 5.804e-05 PLCB1/ARHGAP12/CCL5/SIPA1L1/CXCL13/ARL2/CCL13/RHOH/RGS1/AGAP1/EPHA3/MAPRE2/RASGRP1/ICAM1/CHN1/NTRK3/ARHGEF10/PTK2B/CD40/CCL18/CCR7/S1PR1/DOCK1/RGN/ARHGAP1/RGS2/ARHGAP26/ARHGDIB/PIN1/RAPGEF1/F2R/THY1/DLC1/EFNA5/ACAP1/NTF3/NCKAP1L/TBC1D4/PRKG1/PLXNC1/SGSM2/PLXNA2/ABR/ARHGAP5/ARHGEF5/VAV1/SFRP1/CCL2/STARD8/NPRL3/SPRY1/CCL7/JUN/AMOT 54 BP GO:0043254 regulation of protein complex assembly 53/1096 467/18670 3.21e-06 8.616e-05 5.844e-05 CXCL13/MECP2/ARL2/TMOD1/CORO1A/CRYAB/STXBP1/VEGFA/GSN/ICAM1/LCP1/THRA/AIM2/BIN1/PTK2B/PLEK/CCR7/PAK1/MAPRE3/SPTBN1/CNOT1/CDH5/HCLS1/CAPG/SKAP1/KANK1/ERCC1/CAV3/AKAP9/PINK1/CAMSAP2/LDLRAD4/UNC13B/GMFG/NCKAP1/NCKAP1L/RHOBTB1/APOE/CTNNBIP1/STMN2/G3BP1/CTTN/ARPC3/TWIST1/ARHGEF5/PPM1A/TENM1/PFN2/CUL4A/TFIP11/SMAD6/SELP/JUN 53 BP GO:0043406 positive regulation of MAP kinase activity 35/1096 258/18670 3.247e-06 8.674e-05 5.883e-05 CXCR4/ADAM8/TGFA/VEGFA/EGFR/RASGRP1/DUSP5/NTRK3/PTK2B/CD40/IL1B/PAK1/DAXX/MAPK3/ADORA1/MAP3K4/PTPRC/MAGED1/INSR/FGFR1/SASH1/RAPGEF1/F2R/BMP4/MAP4K1/NTF3/MAPK10/NGF/CSK/ARHGEF5/TENM1/IKBKG/PRDX2/ELANE/FLT1 35 BP GO:0051495 positive regulation of cytoskeleton organization 32/1096 226/18670 3.397e-06 9.017e-05 6.116e-05 MECP2/ARL2/CORO1A/SEMA5A/GSN/ICAM1/NTRK3/BIN1/ARHGEF10/PTK2B/PLEK/SMAD3/GPSM2/CCR7/PAK1/ID1/HCLS1/CAV3/AKAP9/NTF3/GMFG/NCKAP1/NCKAP1L/RHOBTB1/STMN2/CTTN/ARPC3/SPAG5/ARHGEF5/SFRP1/TENM1/PFN2 32 BP GO:0055013 cardiac muscle cell development 18/1096 89/18670 3.406e-06 9.017e-05 6.116e-05 VEGFA/SORBS2/PAK1/MYL2/MYH11/RGS2/MYH10/MYOM2/CAV3/PIN1/BMP4/CCNB1/TTN/MYBPC2/NEB/PDLIM5/PDGFRA/MYOM1 18 BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 33/1096 237/18670 3.479e-06 9.167e-05 6.218e-05 TNFAIP3/LITAF/ANGPT1/RHOH/ADIPOQ/TNFRSF10B/IL1RN/PRKCB/BIRC3/CD40/CPNE1/IL1B/CCR7/HSPB1/TGM2/SLC20A1/TNFSF10/SECTM1/MID2/MYD88/CX3CR1/PLK2/S100A13/F2R/PINK1/HDAC1/PIM2/STAT1/PPM1A/EEF1D/IKBKG/IKBKE/VAPA 33 BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 44/1096 361/18670 3.513e-06 9.212e-05 6.248e-05 TRBC1/TNFAIP3/TNFRSF1B/IL4R/CXCL13/IL7R/RELB/ICAM1/CD226/EMP2/ADA/CD8A/GATA3/CD40/FCGR2B/NFKB2/IL1B/RFTN1/TP53BP1/PTPN6/IL27RA/BATF/RAB27A/CTSC/PTPRC/HPRT1/CD27/CTSH/CCR2/ERCC1/PARP3/IGKC/CFI/CCR6/KDELR1/IGLV6-57/C6/IRF7/NLRP3/APCS/INPP5D/TFRC/IGLC1/C7 44 BP GO:0042692 muscle cell differentiation 46/1096 385/18670 3.647e-06 9.521e-05 6.458e-05 IL4R/MECP2/TMOD1/VEGFA/SORBS2/CDON/SIX1/BIN1/PAK1/SDC1/XBP1/SIK1/TNNT1/MYL2/LDB3/MYH11/RGS2/MYH10/CASQ2/CSRP1/MYOM2/CD53/CAV3/PIN1/SMARCD3/UCHL1/ACTA1/BMP4/GPX1/FZD7/CCNB1/TTN/IGFBP5/MYBPC2/NEB/ADAM12/CXCL10/HDAC4/PDLIM5/TNFSF14/CDH2/CBY1/PDGFRA/MYOM1/RXRA/GLMN 46 BP GO:0002695 negative regulation of leukocyte activation 27/1096 175/18670 3.834e-06 9.933e-05 6.737e-05 RUNX3/TNFAIP3/IL4R/CD200/AXL/LILRB2/IRF1/FCGR2B/PTPN6/PTPRC/CST7/DLG5/CCR2/PTPN22/BMP4/PARP3/LAG3/CD86/ABR/INPP5D/SFRP1/DUSP3/PTPN2/IL2RA/PRDX2/TYRO3/GLMN 27 BP GO:0050851 antigen receptor-mediated signaling pathway 40/1096 316/18670 3.84e-06 9.933e-05 6.737e-05 CD247/TRBC1/CD3D/SH2B2/ITK/LCK/CD226/ADA/GATA3/PRKCB/FCGR2B/RFTN1/CCR7/PAK1/LILRB4/PTPN6/NFKB1/CD38/PTPRC/LCP2/RAB29/PLCG2/THEMIS2/PAK2/CD3G/SKAP1/PTPN22/THY1/IGKC/NCKAP1L/GBP1/PRKCH/CSK/INPP5D/LPXN/IGLC1/DUSP3/PTPN2/IKBKG/LAT 40 BP GO:0002312 B cell activation involved in immune response 16/1096 73/18670 3.94e-06 0.000101 6.851e-05 ADA/PTK2B/CD40/FCGR2B/TP53BP1/XBP1/GPR183/IL27RA/BATF/PTPRC/PLCG2/ERCC1/PARP3/LFNG/CCR6/TFRC 16 BP GO:0030239 myofibril assembly 16/1096 73/18670 3.94e-06 0.000101 6.851e-05 TMOD1/TNNT1/MYL2/LDB3/MYH11/MYH10/CASQ2/CSRP1/MYOM2/CAV3/ACTA1/TTN/MYBPC2/NEB/PDGFRA/MYOM1 16 BP GO:0051402 neuron apoptotic process 33/1096 239/18670 4.184e-06 0.0001068 7.243e-05 TRIM2/ADAM8/MECP2/ANGPT1/CORO1A/TGFB2/STXBP1/TOX3/AXL/SIX1/GATA3/PTK2B/NUPR1/BTG2/HSPA5/CX3CR1/PIN1/HIF1A/F2R/PINK1/NQO1/NTF3/DIO3/APOE/NGF/HDAC4/LGMN/CCL2/BNIP3/WFS1/TYRO3/CRLF1/JUN 33 BP GO:0002224 toll-like receptor signaling pathway 24/1096 146/18670 4.271e-06 0.0001085 7.36e-05 TNFAIP3/IRF1/BIRC3/RFTN1/TRIL/NFKBIA/S100A9/LY96/MFHAS1/CD14/CTSL/LILRA2/MYD88/PTPN22/GRAMD4/TLR2/IRF7/LBP/TRAF3/LGMN/ITGB2/IKBKG/IKBKE/TYRO3 24 BP GO:0010038 response to metal ion 44/1096 364/18670 4.364e-06 0.0001104 7.486e-05 LOXL2/FABP4/GSN/EGFR/ANK3/NDRG1/ICAM1/PTK2B/CPNE1/DAXX/SDC1/MAPK3/NEDD4L/PLN/PAM/ASS1/ANXA11/CCND1/HSPA5/CASQ2/NPC1/CD14/AQP9/MT1G/SYT17/TNNC1/S100A13/ERCC1/HIF1A/ACTA1/GOT1/IGFBP2/NQO1/CDK4/NFE2L1/CCNB1/TTN/AQP1/BAD/QDPR/LGMN/BNIP3/JUN/ADCY1 44 BP GO:0043434 response to peptide hormone 50/1096 436/18670 4.527e-06 0.000114 7.732e-05 FOXO1/TGFBR3/LPL/RARRES2/EGR2/SH2B2/ADIPOQ/PCK1/ICAM1/ENPP1/TIMP4/PRKCB/DAG1/IL1B/PAK1/ADCY9/XBP1/BTG2/PLN/ASS1/NFKB1/STAT4/GOT2/TNFSF10/PDK2/HADH/INSR/COL1A1/ADCY6/CDO1/KANK1/GOT1/CCNA2/CDK4/IGFBP5/TLR2/TBC1D4/HSD11B2/STAT1/QDPR/CSK/CXCL12/AGTR1/PTPN2/INHBB/ATP6V0D1/PTPRE/PCK2/CDC6/ADCY1 50 BP GO:0061448 connective tissue development 36/1096 273/18670 4.567e-06 0.0001145 7.767e-05 RUNX3/CREB3L2/ZBTB16/SOX5/FTO/LOXL2/NFIB/THRA/STC1/SMAD3/SULF1/MGP/XBP1/MAPK3/PITX1/CHI3L1/CD44/PTHLH/SMAD1/COL1A1/OXCT1/FGFR1/ACTA2/HOXA5/HIF1A/ID4/BMP4/CDK4/LRP5/EFEMP1/BMPR1A/CARM1/FGFR3/OSR2/HOXA11/HYAL1 36 BP GO:0007623 circadian rhythm 30/1096 208/18670 4.666e-06 0.0001165 7.9e-05 HUWE1/RELB/EGFR/ADIPOQ/PHLPP1/ADA/NTRK3/NAMPT/ADORA1/SIK1/ID3/ASS1/GNA11/CRX/GFPT1/MAGED1/ID1/EGR3/ID4/CDK4/HDAC1/AHCY/MAPK10/USP7/SERPINE1/IMPDH2/PTGDS/ATF5/JUN/ADCY1 30 BP GO:0002407 dendritic cell chemotaxis 9/1096 24/18670 4.694e-06 0.0001166 7.912e-05 CXCR4/CCL5/CCR7/GPR183/CCR5/GAS6/CCR2/CCR6/ARHGEF5 9 BP GO:0043524 negative regulation of neuron apoptotic process 24/1096 147/18670 4.825e-06 0.0001194 8.098e-05 ADAM8/MECP2/ANGPT1/CORO1A/STXBP1/TOX3/AXL/SIX1/PTK2B/BTG2/CX3CR1/PIN1/HIF1A/F2R/PINK1/NTF3/APOE/NGF/LGMN/CCL2/WFS1/TYRO3/CRLF1/JUN 24 BP GO:2001234 negative regulation of apoptotic signaling pathway 32/1096 230/18670 4.952e-06 0.000122 8.274e-05 TNFAIP3/ITGAV/TNFRSF10B/ICAM1/PCGF2/TCF7L2/IL1B/BCL2L2/XBP1/HSPB1/NOL3/TNFSF10/CD44/TRAP1/CX3CR1/AR/HIF1A/PINK1/BMP4/GPX1/PLAUR/MAPK7/HDAC1/PF4/BCL2A1/SERPINE1/CTTN/CXCL12/WFS1/PRDX2/HERPUD1/PTTG1IP 32 BP GO:0002576 platelet degranulation 22/1096 128/18670 5.044e-06 0.0001237 8.392e-05 SRGN/RARRES2/TGFB2/STXBP1/VEGFA/SERPINA1/ACTN1/CYB5R1/PLEK/MAGED2/APLP2/CFD/GAS6/STXBP2/PECAM1/TTN/TIMP3/PF4/F8/SERPINE1/SELP/ALDOA 22 BP GO:0048146 positive regulation of fibroblast proliferation 13/1096 51/18670 5.389e-06 0.0001308 8.872e-05 DDR2/EGFR/BTC/GAS6/CCNA2/CDK4/CCNB1/ZMIZ1/AQP1/FOSL2/PDGFRA/CDC6/JUN 13 BP GO:0016054 organic acid catabolic process 36/1096 275/18670 5.401e-06 0.0001308 8.872e-05 ALDH6A1/ECH1/ADIPOQ/FAH/PCK1/CRAT/ECI1/ECHS1/GOT2/HPD/CD44/ACADS/HADH/SLC27A2/BCAT1/BCKDHA/CDO1/HDC/ALDH5A1/ASPA/PCBD1/ACOX2/GOT1/AHCY/PGD/QDPR/HEXA/TWIST1/CRYM/TST/ALDH3A2/SDS/PLA2G15/HYAL1/PCK2/ETFB 36 BP GO:0046395 carboxylic acid catabolic process 36/1096 275/18670 5.401e-06 0.0001308 8.872e-05 ALDH6A1/ECH1/ADIPOQ/FAH/PCK1/CRAT/ECI1/ECHS1/GOT2/HPD/CD44/ACADS/HADH/SLC27A2/BCAT1/BCKDHA/CDO1/HDC/ALDH5A1/ASPA/PCBD1/ACOX2/GOT1/AHCY/PGD/QDPR/HEXA/TWIST1/CRYM/TST/ALDH3A2/SDS/PLA2G15/HYAL1/PCK2/ETFB 36 BP GO:0001906 cell killing 26/1096 168/18670 5.438e-06 0.0001311 8.895e-05 IL7R/CORO1A/CCL13/GZMB/RASGRP1/ICAM1/CD226/EMP2/SH2D1A/FCGR2B/PTPN6/RAB27A/CTSC/PTPRC/CRTAM/DNASE1L3/HPRT1/STXBP2/CTSH/CXCL6/LAG3/PF4/BAD/GNLY/VAV1/ELANE 26 BP GO:0070661 leukocyte proliferation 38/1096 298/18670 5.598e-06 0.0001344 9.117e-05 TNFAIP3/TNFRSF1B/CCL5/RAC2/IL7R/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/HPRT1/DLG5/CCR2/PTPN22/BMP4/IGFBP2/ELF4/TNFRSF4/PURA/NCKAP1L/SATB1/HLA-DMB/CD86/INPP5D/TFRC/TNFSF14/IL2RA/IMPDH1/IMPDH2/PRDX2/IL15/GLMN 38 BP GO:0043523 regulation of neuron apoptotic process 30/1096 210/18670 5.677e-06 0.0001357 9.207e-05 TRIM2/ADAM8/MECP2/ANGPT1/CORO1A/TGFB2/STXBP1/TOX3/AXL/SIX1/GATA3/PTK2B/NUPR1/BTG2/CX3CR1/PIN1/HIF1A/F2R/PINK1/NQO1/NTF3/APOE/NGF/HDAC4/LGMN/CCL2/WFS1/TYRO3/CRLF1/JUN 30 BP GO:0061756 leukocyte adhesion to vascular endothelial cell 12/1096 44/18670 5.77e-06 0.0001374 9.319e-05 ITGB7/ICAM1/SELPLG/PTAFR/ITGA4/CX3CR1/CCR2/SELL/CXCL12/ITGB2/SELP/ELANE 12 BP GO:0032147 activation of protein kinase activity 41/1096 333/18670 5.838e-06 0.0001384 9.39e-05 CXCR4/CCL5/ANGPT1/TGFA/TGFB2/VEGFA/EGFR/TNFRSF10B/DUSP5/EMP2/NTRK3/PTK2B/IL1B/PAK1/DAXX/ADCY9/MAPK3/ADORA1/MAP3K4/CHI3L1/PTPRC/INSR/PAK2/ADCY6/GAS6/NEK1/RAPGEF1/F2R/PINK1/STK10/BMP4/EFNA5/MAP4K1/NTF3/NCKAP1L/MAPK10/NGF/TPX2/IKBKG/PRDX2/ADCY1 41 BP GO:0001558 regulation of cell growth 48/1096 416/18670 5.922e-06 0.0001398 9.485e-05 SPP1/SERPINE2/CXCR4/CRYAB/SEMA5A/TGFB2/VEGFA/SEMA3E/EGFR/SEMA3A/CLSTN1/ENPP1/HBEGF/NTRK3/PTK2B/ADIPOR2/SMAD3/IGFBP7/PAK1/NEDD4L/KAZALD1/MYL2/S100A9/FBLN5/CD38/RGS2/CDKN2C/OLFM1/SYT17/CAV3/SEMA3C/PIN1/LTBP4/SEMA4F/EFNA5/PHB/IGFBP5/APOE/NGF/CTTN/CXCL12/KIAA1109/AGTR1/SFRP1/FHL1/DPYSL2/TSPYL2/HYAL1 48 BP GO:0003014 renal system process 21/1096 120/18670 6.139e-06 0.0001444 9.793e-05 HBB/GSN/ADIPOQ/EMP2/STC1/AKR1B1/MAGED2/SULF1/ADCY9/ADORA1/BTC/ADCY6/GAS6/F2R/BMP4/AQP1/HSD11B2/AGTR1/LGMN/WFS1/ADCY1 21 BP GO:0043900 regulation of multi-organism process 47/1096 405/18670 6.334e-06 0.0001483 0.0001006 PLCB1/FCN1/TNFAIP3/CXCR4/CCL5/STXBP1/GSN/ITGAV/HPGDS/ADA/SLPI/AIM2/BIRC3/IL1B/MAPK3/CXCL8/PTAFR/LY96/MID2/LILRA2/PLSCR1/ISG20/PC/ARHGDIB/SASH1/CXCL6/LAMP3/UNC13B/POLR2E/HDAC1/PCBP2/BAD/HTRA1/STAT1/APOE/HDAC4/APCS/TRAF3/POLR2I/TFAP4/IL2RA/PRDX2/VAPA/INHBB/IL15/JUN/SUPT5H 47 BP GO:0001823 mesonephros development 19/1096 102/18670 6.586e-06 0.0001536 0.0001042 ZBTB16/VEGFA/SIX1/GATA3/SMAD3/SDC1/MAGED1/SMAD1/FGFR1/BMP4/BASP1/CTNNBIP1/FOXC1/SFRP1/OSR2/HOXA11/SPRY1/SMAD6/CRLF1 19 BP GO:0036293 response to decreased oxygen levels 44/1096 370/18670 6.667e-06 0.0001549 0.000105 TGFBR3/CXCR4/ADAM8/MECP2/LOXL2/CRYAB/TGFB2/VEGFA/PDLIM1/ADIPOQ/NDRG1/PCK1/ICAM1/ADA/PTK2B/STC1/NAMPT/POSTN/SMAD3/HK2/PAK1/ADORA1/PAM/NOL3/CD38/TM9SF4/MB/UCP2/PIN1/HIF1A/PINK1/CCNA2/CCNB1/AQP1/AHCY/BAD/TLR2/HSD11B2/DDIT4/CXCL12/TWIST1/SFRP1/ANGPT2/BNIP3 44 BP GO:0072073 kidney epithelium development 23/1096 140/18670 6.794e-06 0.0001572 0.0001066 MAGI2/WWTR1/VEGFA/ADIPOQ/SIX1/GATA3/SMAD3/SDC1/MAGED1/SMAD1/FGFR1/BMP4/PECAM1/BASP1/STAT1/CTNNBIP1/LAMB2/FOXC1/SFRP1/HOXA11/SPRY1/SMAD6/CRLF1 23 BP GO:0001666 response to hypoxia 43/1096 359/18670 7.055e-06 0.0001626 0.0001103 TGFBR3/CXCR4/ADAM8/MECP2/LOXL2/CRYAB/TGFB2/VEGFA/PDLIM1/ADIPOQ/NDRG1/PCK1/ICAM1/ADA/PTK2B/STC1/POSTN/SMAD3/HK2/PAK1/ADORA1/PAM/NOL3/CD38/TM9SF4/MB/UCP2/PIN1/HIF1A/PINK1/CCNA2/CCNB1/AQP1/AHCY/BAD/TLR2/HSD11B2/DDIT4/CXCL12/TWIST1/SFRP1/ANGPT2/BNIP3 43 BP GO:0050918 positive chemotaxis 15/1096 68/18670 7.226e-06 0.0001658 0.0001125 CCL5/ANGPT1/CORO1A/SEMA5A/VEGFA/NTRK3/SMAD3/S1PR1/CXCL8/BMP4/NTF3/CXCL10/CXCL12/SAA4/ANGPT2 15 BP GO:0045576 mast cell activation 14/1096 60/18670 7.255e-06 0.0001658 0.0001125 IL4R/RAC2/RHOH/STXBP1/RASGRP1/NDRG1/CD226/GAB2/LCP2/PLSCR1/GATA2/STXBP2/S100A13/LAT 14 BP GO:0002285 lymphocyte activation involved in immune response 27/1096 181/18670 7.312e-06 0.0001665 0.0001129 IL4R/CORO1A/RELB/ICAM1/ADA/LCP1/GATA3/PTK2B/CD40/FCGR2B/TP53BP1/XBP1/GPR183/IL27RA/ITGAL/BATF/RAB27A/PTPRC/PLCG2/ERCC1/PARP3/LFNG/CCR6/HLA-DMB/CD86/NLRP3/TFRC 27 BP GO:0006937 regulation of muscle contraction 26/1096 171/18670 7.556e-06 0.0001709 0.0001159 ADA/BIN1/STC1/ADORA1/PLN/TNNT1/MYL2/PTAFR/RGS2/CASQ2/TNNC2/MYL9/MYH7/TNNC1/CAV3/MYL3/AKAP9/F2R/TNNI1/ATP2A1/HSPB6/PRKG1/KCNB2/HDAC4/CTTN/CHRM3 26 BP GO:0090130 tissue migration 43/1096 360/18670 7.57e-06 0.0001709 0.0001159 CXCL13/MECP2/ANGPT1/LOXL2/SEMA5A/TGFB2/VEGFA/MAPRE2/SEMA3A/EMP2/HBEGF/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/DOCK1/ID1/EGR3/FGFR1/SASH1/PLK2/GATA2/CTSH/KANK1/ACTA2/HIF1A/ACTA1/BMP4/GPX1/PECAM1/CCR6/APOE/PTP4A3/LGMN/NRP2/ITGB2/ANGPT2/PFN2/HYAL1/JUN/AMOT 43 BP GO:0031334 positive regulation of protein complex assembly 35/1096 268/18670 7.659e-06 0.0001723 0.0001168 CXCL13/MECP2/ARL2/CORO1A/VEGFA/GSN/ICAM1/LCP1/AIM2/BIN1/PTK2B/PLEK/CCR7/PAK1/CNOT1/CDH5/SKAP1/ERCC1/CAV3/AKAP9/PINK1/UNC13B/GMFG/NCKAP1/NCKAP1L/RHOBTB1/G3BP1/CTTN/ARPC3/TWIST1/ARHGEF5/TENM1/PFN2/CUL4A/JUN 35 BP GO:0051271 negative regulation of cellular component movement 45/1096 384/18670 7.709e-06 0.0001727 0.0001171 PLCB1/TGFBR3/MAGI2/CXCL13/MECP2/SEMA5A/SEMA3E/CD200/ADIPOQ/SEMA3A/ADA/GATA3/BIN1/STC1/DAG1/ACTN1/SULF1/ADORA3/ADORA1/IL27RA/RGN/CX3CR1/ARHGDIB/DLG5/KANK1/SEMA3C/PIN1/THY1/SEMA4F/LDLRAD4/DLC1/IGFBP5/PRKG1/APOE/SERPINE1/BMPR1A/CXCL12/ABR/SFRP1/DUSP3/ANGPT2/CCL2/SPINT2/PFN2/COL3A1 45 BP GO:0046777 protein autophosphorylation 32/1096 235/18670 7.81e-06 0.0001743 0.0001182 DDR2/GRK5/VEGFA/EGFR/ADIPOQ/ITK/LCK/ENPP1/PTK2B/GFRA2/PAK1/MAPK3/SIK1/PTPRC/STK17B/CLK1/INSR/PAK2/FGFR1/THY1/PINK1/STK10/PIM1/MAP4K1/SLA/PIM2/CSK/FGFR3/PDGFRA/TYRO3/FLT1/JUN 32 BP GO:0044282 small molecule catabolic process 50/1096 445/18670 8.009e-06 0.0001777 0.0001205 ALDH6A1/ECH1/ADIPOQ/FAH/PCK1/ADA/PFKM/HK2/CRAT/ECI1/GK/ECHS1/GOT2/HPD/CD44/ACADS/HADH/HPRT1/SLC27A2/OXCT1/BCAT1/BCKDHA/CDO1/HDC/ALDH5A1/ALDH3B1/ASPA/PCBD1/ACOX2/GOT1/LRP5/AKR1B10/AHCY/BAD/APOE/PGD/QDPR/HEXA/TWIST1/CRYM/TST/ALDH3A2/SDS/PLA2G15/TYMP/ALDOA/HYAL1/PCK2/NUDT3/ETFB 50 BP GO:0034101 erythrocyte homeostasis 21/1096 122/18670 8.023e-06 0.0001777 0.0001205 TGFBR3/VEGFA/AXL/THRA/GATA3/MFHAS1/AMPD3/HCLS1/MB/GATA2/HOXA5/HIF1A/BMP4/NFE2L1/JMJD6/NCKAP1L/IKZF1/STAT1/INPP5D/PTPN2/TRIM58 21 BP GO:0030278 regulation of ossification 29/1096 203/18670 8.083e-06 0.0001783 0.0001209 ZBTB16/DDR2/SRGN/EGR2/TGFB2/ZHX3/ENPP1/PTK2B/SMAD3/S1PR1/MGP/MAPK3/NELL1/ID3/SMAD1/ID1/HIF1A/BMP4/LRP5/IGFBP5/DHRS3/CTNNBIP1/GDF10/HDAC4/BMPR1A/TWIST1/SFRP1/OSR2/SMAD6 29 BP GO:0051098 regulation of binding 44/1096 373/18670 8.201e-06 0.0001802 0.0001222 TGFBR3/DZIP1/ANGPT1/CDON/ADIPOQ/SLPI/GATA3/CPNE1/TCF7L2/SMAD3/MAPK3/PLN/MAPRE3/ID3/NFKBIA/GZMA/HSPA5/PEX19/LDOC1/ITGA4/ID1/PLK2/PIN1/SMARCD3/PCBD1/ID4/BMP4/PLAUR/LFNG/PIM2/APOE/NGF/CTNNBIP1/PHLDA2/HDAC4/TWIST1/PTPRF/FOXC1/CARM1/TFAP4/PLK1/TFIP11/JUN/MBD2 44 BP GO:0055007 cardiac muscle cell differentiation 22/1096 132/18670 8.436e-06 0.0001846 0.0001252 VEGFA/SORBS2/PAK1/SIK1/MYL2/MYH11/RGS2/MYH10/MYOM2/CAV3/PIN1/BMP4/FZD7/CCNB1/TTN/MYBPC2/NEB/PDLIM5/CBY1/PDGFRA/MYOM1/RXRA 22 BP GO:0031098 stress-activated protein kinase signaling cascade 39/1096 315/18670 8.585e-06 0.0001872 0.000127 FOXO1/PLCB1/CRYAB/TGFB2/VEGFA/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/AKR1B1/SLAMF1/CCR7/PAK1/DAXX/MAPK3/MAP3K4/NFKB1/MFHAS1/PAK2/CD27/SASH1/NEK1/PTPN22/CAV3/RAPGEF1/PINK1/STK10/MAP4K1/FZD7/MAPK10/MAPK13/ARHGEF5/SFRP1/DUSP3/IKBKG 39 BP GO:0032675 regulation of interleukin-6 production 24/1096 152/18670 8.712e-06 0.0001892 0.0001283 TNFAIP3/ZBTB20/LPL/CD200/IL1RN/LILRB2/IL1B/SLAMF1/XBP1/PTPN6/IL27RA/PTAFR/LILRA2/MYD88/GAS6/PTPN22/F2R/NCKAP1L/TLR2/MAPK13/LBP/CSK/TWIST1/INPP5D 24 BP GO:0002573 myeloid leukocyte differentiation 29/1096 204/18670 8.905e-06 0.000192 0.0001302 RELB/VEGFA/ADIPOQ/GATA3/TCTA/CCR7/LILRB4/GPR183/GAB2/BATF/MT1G/HCLS1/GATA2/TSPAN2/BMP4/LBR/PF4/TLR2/CTNNBIP1/LILRB3/IRF7/APCS/INPP5D/TFRC/SFRP1/PTPN2/CUL4A/IL15/JUN 29 BP GO:1902905 positive regulation of supramolecular fiber organization 29/1096 204/18670 8.905e-06 0.000192 0.0001302 MECP2/ARL2/CORO1A/SEMA5A/GSN/ICAM1/BIN1/ARHGEF10/PTK2B/PLEK/SMAD3/CCR7/PAK1/ID1/CAV3/AKAP9/GPX1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/APOE/STMN2/CTTN/ARPC3/ARHGEF5/SFRP1/TENM1/PFN2 29 BP GO:0051651 maintenance of location in cell 18/1096 95/18670 8.941e-06 0.000192 0.0001302 SRGN/ARL2/GSN/ANK3/FLNB/DAG1/HK2/GPSM2/TLN2/HSPA5/GPAA1/AKAP9/PINK1/ATP2A1/KDELR3/VPS13A/KDELR1/APOE 18 BP GO:0022604 regulation of cell morphogenesis 53/1096 484/18670 9.068e-06 0.000194 0.0001316 SPP1/UST/CXCR4/PARVA/SIPA1L1/CORO1A/CCL13/SEMA5A/RHOH/VEGFA/SEMA3E/SEMA3A/ICAM1/CHN1/ZNF135/NTRK3/PTK2B/CUX1/DAG1/RHOBTB3/POSTN/PAK1/DNMBP/NEDD4L/DOCK1/MYH10/CD44/PDPN/FAM171A1/ID1/OLFM1/SYT17/S100A13/KANK1/SEMA3C/THY1/SEMA4F/DLC1/EFNA5/GBP1/APOE/NGF/PLXNC1/CTTN/PLXNA2/PDLIM5/CXCL12/CDH2/ITGB2/CCL2/DPYSL2/CCL7/ALDOA 53 BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 30/1096 215/18670 9.141e-06 0.0001948 0.0001321 CCL5/ANGPT1/CCL13/P2RY6/EGFR/RASGRP1/ICAM1/PTK2B/CCL18/SLAMF1/CCR7/MAPK3/GPR183/CHI3L1/CD44/PTPRC/MFHAS1/GAS6/PTPN22/RAPGEF1/F2R/BMP4/PHB/APOE/FGFR3/CCL2/PDGFRA/CCL7/FLT1/JUN 30 BP GO:0071353 cellular response to interleukin-4 10/1096 32/18670 9.174e-06 0.0001948 0.0001321 IL4R/IL2RG/CORO1A/GATA3/TCF7/XBP1/HSPA5/CDK4/PTPN2/IMPDH2 10 BP GO:0045862 positive regulation of proteolysis 43/1096 363/18670 9.327e-06 0.0001973 0.0001338 TNFRSF1B/ADAM8/GSN/TNFRSF10B/LCK/AIM2/PTK2B/NUPR1/IL1B/SMAD3/CTSD/MAPK3/DAP/RGN/S100A9/RNF144A/CTSC/TNFSF10/TRIB2/ASPH/PLK2/CTSH/CASP4/CAV3/F2R/PINK1/DLC1/PHB/HIP1/BAD/GRAMD4/APOE/NGF/C6/NLRP3/TFAP4/LGMN/PLK1/USP5/CYFIP2/PCOLCE/HERPUD1/TNP2 43 BP GO:1904036 negative regulation of epithelial cell apoptotic process 12/1096 46/18670 9.545e-06 0.0002012 0.0001365 TNFAIP3/ANGPT1/SEMA5A/ICAM1/GATA3/NUPR1/TCF7L2/GAS6/GATA2/MAPK7/SERPINE1/WFS1 12 BP GO:0043409 negative regulation of MAPK cascade 27/1096 184/18670 9.967e-06 0.0002093 0.000142 FOXO1/ADIPOQ/DUSP5/DAG1/IL1B/PTPN6/RGS2/PTPRC/DUSP14/PTPN22/CAV3/PIN1/RAPGEF1/PINK1/UCHL1/BMP4/PHB/TIMP3/GBP1/APOE/LMO3/DUSP2/CSK/SFRP1/DUSP3/PTPN2/SPRY1 27 BP GO:0001667 ameboidal-type cell migration 51/1096 461/18670 1.006e-05 0.0002104 0.0001427 DDR2/ITGB7/CXCL13/MECP2/ANGPT1/LOXL2/SEMA5A/TGFB2/VEGFA/SEMA3E/MAPRE2/SEMA3A/EMP2/HBEGF/AKT3/GATA3/PTK2B/CD40/STC1/PAK1/HSPB1/DOCK1/ITGA4/ID1/EGR3/ARHGDIB/FGFR1/SASH1/PLK2/GATA2/CTSH/KANK1/SEMA3C/HIF1A/SEMA4F/BMP4/GPX1/PECAM1/CCR6/APOE/TWIST1/AMOTL2/PTP4A3/LGMN/NRP2/ITGB2/ANGPT2/PFN2/HYAL1/JUN/AMOT 51 BP GO:0006941 striated muscle contraction 26/1096 174/18670 1.04e-05 0.0002168 0.0001471 CXCR4/SYNM/BIN1/STC1/EEF2/ADORA1/NEDD4L/PLN/TNNT1/MYL2/RGS2/KCNJ8/CASQ2/TNNC2/MB/MYH7/TNNC1/CAV3/MYL3/TNNI1/ATP2A1/SNTA1/MYL1/TTN/HDAC4/ALDOA 26 BP GO:0010975 regulation of neuron projection development 54/1096 499/18670 1.052e-05 0.000217 0.0001472 CREB3L2/SPP1/UST/CXCR4/MAGI2/SIPA1L1/SEMA5A/VEGFA/EPHA3/SEMA3E/SEMA3A/CHN1/GATA3/NTRK3/PTK2B/ZNF365/CUX1/SHANK2/PAK1/NEDD4L/S100A9/CD38/RGS2/HSPA5/RAB29/ID1/ADCY6/FGFR1/DLG5/PLK2/OLFM1/SYT17/INPP5F/KANK1/SEMA3C/RAPGEF1/THY1/SEMA4F/CAMSAP2/EFNA5/APOE/NGF/PLXNC1/STMN2/CTTN/PLXNA2/PDLIM5/CXCL12/PTPRF/CARM1/CDH2/SFRP1/COBL/DPYSL2 54 BP GO:0033077 T cell differentiation in thymus 15/1096 70/18670 1.052e-05 0.000217 0.0001472 CD3D/ADAM8/IL7R/RASGRP1/ADA/GATA3/CCR7/PTPRC/EGR3/CD3G/BMP4/FZD7/JMJD6/CCR6/PTPN2 15 BP GO:0050766 positive regulation of phagocytosis 15/1096 70/18670 1.052e-05 0.000217 0.0001472 IL15RA/IL2RG/IL2RB/ITGAV/FCGR2B/IL1B/RAB27A/PTPRC/GAS6/GATA2/RAPGEF1/NCKAP1L/ABR/CCL2/IL15 15 BP GO:0032663 regulation of interleukin-2 production 13/1096 54/18670 1.064e-05 0.0002186 0.0001483 TNFAIP3/GATA3/IL1B/SPTBN1/PTPRC/CD83/CCR2/HOMER3/LAG3/GBP1/KAT5/CD86/GLMN 13 BP GO:0032355 response to estradiol 22/1096 134/18670 1.081e-05 0.0002213 0.0001501 CRYAB/STXBP1/EGFR/EEF2/POSTN/GPX4/CSN1S1/BCL2L2/PAM/ASS1/CCND1/CD38/COL1A1/TFPI/CCNA2/IGFBP2/NQO1/BAD/KAT5/SFRP1/MMP15/MBD2 22 BP GO:0032623 interleukin-2 production 14/1096 62/18670 1.09e-05 0.0002222 0.0001507 CD247/TNFAIP3/GATA3/IL1B/SPTBN1/PTPRC/CD83/CCR2/HOMER3/LAG3/GBP1/KAT5/CD86/GLMN 14 BP GO:0003151 outflow tract morphogenesis 16/1096 79/18670 1.156e-05 0.0002342 0.0001588 TGFBR3/PARVA/TGFB2/VEGFA/SIX1/FZD2/SEMA3C/HIF1A/BMP4/DHRS3/BMPR1A/TWIST1/FOXC1/NRP2/SMAD6/JUN 16 BP GO:0071260 cellular response to mechanical stimulus 16/1096 79/18670 1.156e-05 0.0002342 0.0001588 EGFR/TNFRSF10B/IRF1/CD40/DAG1/IL1B/MAPK3/NFKB1/MYD88/COL1A1/GOT1/AQP1/BAD/HDAC4/TNFSF14/BNIP3 16 BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 17/1096 88/18670 1.206e-05 0.0002422 0.0001643 ZBTB20/LPL/ADAM8/RASGRP1/CD2/HSPB1/PTAFR/PTPRC/LY96/CD14/LILRA2/CCR2/PF4/TLR2/CD86/LBP/TWIST1 17 BP GO:0019722 calcium-mediated signaling 30/1096 218/18670 1.206e-05 0.0002422 0.0001643 CXCR4/P2RY6/EGFR/NCALD/ADA/PTK2B/PLEK/CCR7/PLN/RGN/CXCL8/CCR5/PTPRC/CASQ2/PDK2/PLCG2/CX3CR1/CCR2/DYRK2/CXCR6/HOMER3/MAPK7/CCR6/GBP1/HDAC4/AGTR1/CAMTA1/PPP3CC/SELP/LAT 30 BP GO:0051591 response to cAMP 18/1096 97/18670 1.209e-05 0.0002422 0.0001643 ADIPOQ/PCK1/PTK2B/STC1/SDC1/ASS1/PTAFR/HSPA5/AQP9/COL1A1/CDO1/AKAP9/RAPGEF1/AQP1/IGFBP5/STAT1/CARM1/JUN 18 BP GO:0061614 pri-miRNA transcription by RNA polymerase II 12/1096 47/18670 1.214e-05 0.0002424 0.0001644 TGFB2/NFIB/SMAD3/LILRB4/SMAD1/GATA2/HIF1A/BMP4/HDAC4/BMPR1A/SMAD6/JUN 12 BP GO:0002886 regulation of myeloid leukocyte mediated immunity 13/1096 55/18670 1.319e-05 0.0002618 0.0001776 IL4R/RAC2/STXBP1/FCGR2B/GAB2/PTAFR/DNASE1L3/GATA2/STXBP2/CCR2/CXCL6/ABR/ITGB2 13 BP GO:0048762 mesenchymal cell differentiation 30/1096 219/18670 1.32e-05 0.0002618 0.0001776 TGFBR3/LOXL2/SEMA5A/WWTR1/TGFB2/EPHA3/SEMA3E/SEMA3A/DAG1/IL1B/SMAD3/FAM172A/MAPK3/PDPN/COL1A1/FGFR1/DLG5/OLFM1/SEMA3C/HIF1A/SEMA4F/LDLRAD4/BMP4/STAT1/BMPR1A/TWIST1/FOXC1/SFRP1/NRP2/SPRY1 30 BP GO:0042542 response to hydrogen peroxide 23/1096 146/18670 1.384e-05 0.0002735 0.0001855 FOXO1/TNFAIP3/CRYAB/HBB/AXL/ADA/PCGF2/PTK2B/EEF2/SDC1/TRAP1/COL1A1/MB/PINK1/GPX1/NQO1/MAPK7/AQP1/BAD/STAT1/MAPK13/BNIP3/JUN 23 BP GO:0060541 respiratory system development 28/1096 198/18670 1.396e-05 0.0002749 0.0001864 VEGFA/EGFR/SIX1/NFIB/ADA/THRA/DAG1/RBP4/MAPK3/ASS1/CHI3L1/ADAMTS2/PDPN/KCNAB1/ID1/FGFR1/DLG5/CTSH/HOXA5/BMP4/JMJD6/BASP1/IGFBP5/BMPR1A/SIM2/PDGFRA/SPRY1/ADAMTSL2 28 BP GO:0050764 regulation of phagocytosis 18/1096 98/18670 1.401e-05 0.0002749 0.0001864 IL15RA/IL2RG/IL2RB/ITGAV/ADIPOQ/FCGR2B/IL1B/RAB27A/PTPRC/GAS6/GATA2/RAPGEF1/NCKAP1L/TLR2/CSK/ABR/CCL2/IL15 18 BP GO:0051216 cartilage development 29/1096 209/18670 1.428e-05 0.0002793 0.0001895 RUNX3/CREB3L2/ZBTB16/SOX5/LOXL2/NFIB/THRA/STC1/SMAD3/SULF1/MGP/MAPK3/PITX1/CHI3L1/CD44/PTHLH/SMAD1/COL1A1/FGFR1/HOXA5/HIF1A/BMP4/EFEMP1/BMPR1A/CARM1/FGFR3/OSR2/HOXA11/HYAL1 29 BP GO:0036336 dendritic cell migration 9/1096 27/18670 1.434e-05 0.0002794 0.0001895 CXCR4/CCL5/CCR7/GPR183/CCR5/GAS6/CCR2/CCR6/ARHGEF5 9 BP GO:0032535 regulation of cellular component size 43/1096 370/18670 1.499e-05 0.0002911 0.0001975 SPP1/IL7R/TMOD1/CORO1A/SEMA5A/VEGFA/GSN/SEMA3E/SEMA3A/ICAM1/AKT3/NTRK3/BIN1/PTK2B/PLEK/CCR7/PAK1/SPTBN1/HCLS1/CAPG/OLFM1/KANK1/CAV3/SEMA3C/SEMA4F/EFNA5/CDK4/GMFG/NCKAP1/AQP1/NCKAP1L/RHOBTB1/APOE/NGF/NEB/RAB22A/CTTN/ARPC3/CXCL12/VAV1/TENM1/PFN2/DPYSL2 43 BP GO:0048608 reproductive structure development 48/1096 431/18670 1.529e-05 0.000296 0.0002008 SPP1/SERPINE2/ADAM19/HOXA10/TGFB2/VEGFA/EGFR/AXL/SEMA3A/ICAM1/ADA/GATA3/ATRX/STC1/TCF7/NUPR1/RHOBTB3/SULF1/BCL2L2/SDC1/RBP4/MAPK3/MAP3K4/CCND1/TNFSF10/HSPA5/LDOC1/INSR/AR/GATA2/ERCC1/HIF1A/ID4/BMP4/LFNG/BASP1/HTRA1/PHLDA2/FOXC1/ASB1/SFRP1/SPINT2/PDGFRA/HOXA11/ST14/RXRA/TYRO3/INHBB 48 BP GO:0002262 myeloid cell homeostasis 23/1096 147/18670 1.551e-05 0.0002992 0.000203 TGFBR3/VEGFA/AXL/THRA/GATA3/MFHAS1/AMPD3/HCLS1/MB/GATA2/CCR2/HOXA5/HIF1A/BMP4/NFE2L1/JMJD6/NCKAP1L/FANCC/IKZF1/STAT1/INPP5D/PTPN2/TRIM58 23 BP GO:0048247 lymphocyte chemotaxis 14/1096 64/18670 1.606e-05 0.0003089 0.0002095 CCL5/ADAM8/CXCL13/CCL13/CH25H/PTK2B/CCL18/GPR183/GAS6/CCR2/CXCL10/TNFSF14/CCL2/CCL7 14 BP GO:0110110 positive regulation of animal organ morphogenesis 16/1096 81/18670 1.612e-05 0.000309 0.0002096 TNFAIP3/TGFB2/VEGFA/SIX1/GATA3/XBP1/MAGED1/AR/FGFR1/SEMA3C/BMP4/PIM1/BASP1/TWIST1/HOXA11/SPRY1 16 BP GO:0071674 mononuclear cell migration 17/1096 90/18670 1.644e-05 0.000314 0.000213 PLCB1/CCL5/RARRES2/CCL13/CCL18/MAPK3/CCR2/PECAM1/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN/C3AR1/CCL2/CCL7/FLT1 17 BP GO:0070670 response to interleukin-4 10/1096 34/18670 1.675e-05 0.0003187 0.0002162 IL4R/IL2RG/CORO1A/GATA3/TCF7/XBP1/HSPA5/CDK4/PTPN2/IMPDH2 10 BP GO:0040013 negative regulation of locomotion 45/1096 396/18670 1.693e-05 0.0003212 0.0002178 PLCB1/MAGI2/CXCL13/MECP2/SEMA5A/SEMA3E/CD200/ADIPOQ/SEMA3A/ADA/GATA3/STC1/DAG1/SULF1/ADORA3/ADORA1/IL27RA/RGN/MID2/CX3CR1/ARHGDIB/DLG5/KANK1/SEMA3C/PIN1/THY1/SEMA4F/LDLRAD4/DLC1/IGFBP5/PRKG1/APOE/SERPINE1/BMPR1A/CXCL12/ABR/SFRP1/DUSP3/PTPN2/ANGPT2/CCL2/SPINT2/PFN2/COL3A1/ELANE 45 BP GO:0032606 type I interferon production 21/1096 128/18670 1.721e-05 0.0003253 0.0002207 TNFAIP3/ZBTB20/RELB/IRF1/NFKB2/NFKB1/CD14/MYD88/PLCG2/PTPN22/PIN1/NMI/POLR2E/PCBP2/TLR2/STAT1/G3BP1/IRF7/TRAF3/POLR1C/IKBKE 21 BP GO:0044706 multi-multicellular organism process 30/1096 222/18670 1.726e-05 0.0003253 0.0002207 SPP1/SERPINE2/EMP2/STC1/IL1B/AKR1B1/NAMPT/MAGED2/ADIPOR2/CLIC5/IGFBP7/MAPK3/PAM/PTAFR/GOT2/CD38/RGS2/LDOC1/PTHLH/ARHGDIB/AR/ITGA5/IGFBP2/IGFBP5/HSD11B2/MAFF/ANGPT2/STS/RXRA/TNP2 30 BP GO:2001235 positive regulation of apoptotic signaling pathway 26/1096 179/18670 1.737e-05 0.0003263 0.0002213 GZMB/GSN/LCK/NUPR1/SMAD3/S100A9/CTSC/TNFSF10/PTPRC/NACC2/MAGED1/PAK2/CTSH/PINK1/G0S2/PLAUR/ZNF205/TIMP3/BAD/MLLT11/TFAP4/SFRP1/PTPN2/BNIP3/PPP3CC/INHBB 26 BP GO:0042063 gliogenesis 36/1096 290/18670 1.777e-05 0.0003326 0.0002256 TNFRSF1B/SERPINE2/CXCR4/EGR2/TGFB2/GSN/EGFR/NDRG1/NFIB/NTRK3/BIN1/ARHGEF10/PTK2B/ZNF365/DAG1/IL1B/EEF2/MAPK3/GPR183/CDKN2C/MXRA8/CX3CR1/CCR2/ASPA/ID4/TSPAN2/NFE2L1/HDAC1/TLR2/PRKCH/CSK/LAMB2/CDH2/CCL2/BNIP3/GAP43 36 BP GO:0003208 cardiac ventricle morphogenesis 15/1096 73/18670 1.798e-05 0.0003354 0.0002275 TGFBR3/TGFB2/GATA3/MYL2/MYH7/TNNC1/SEMA3C/MYL3/SMARCD3/HIF1A/TNNI1/UBE4B/BMPR1A/FOXC1/RXRA 15 BP GO:0060759 regulation of response to cytokine stimulus 27/1096 190/18670 1.807e-05 0.000336 0.0002279 TNFAIP3/CXCR4/CCL5/IFNAR2/ANGPT1/ADIPOQ/AXL/PXDN/IL1RN/BIRC3/CPNE1/PTPN6/NOL3/PTPRC/TRAF1/GAS6/CASP4/HIF1A/MAPK7/TLR2/STAT1/IRF7/AGPAT1/PTPN2/LIFR/IKBKG/IKBKE 27 BP GO:0050728 negative regulation of inflammatory response 25/1096 169/18670 1.823e-05 0.000338 0.0002293 TNFAIP3/TNFRSF1B/TNFAIP6/CD200/ADIPOQ/ADA/GATA3/FCGR2B/SMAD3/ADORA1/NFKB1/PTPRC/CDH5/MFHAS1/CST7/GPX1/MAPK7/APOE/ABR/NLRP3/APCS/PTPN2/IL2RA/TYRO3/ELANE 25 BP GO:0061458 reproductive system development 48/1096 434/18670 1.834e-05 0.0003389 0.0002299 SPP1/SERPINE2/ADAM19/HOXA10/TGFB2/VEGFA/EGFR/AXL/SEMA3A/ICAM1/ADA/GATA3/ATRX/STC1/TCF7/NUPR1/RHOBTB3/SULF1/BCL2L2/SDC1/RBP4/MAPK3/MAP3K4/CCND1/TNFSF10/HSPA5/LDOC1/INSR/AR/GATA2/ERCC1/HIF1A/ID4/BMP4/LFNG/BASP1/HTRA1/PHLDA2/FOXC1/ASB1/SFRP1/SPINT2/PDGFRA/HOXA11/ST14/RXRA/TYRO3/INHBB 48 BP GO:0050715 positive regulation of cytokine secretion 22/1096 139/18670 1.96e-05 0.0003607 0.0002447 FCN1/IL4R/LPL/RASGRP1/GATA3/AIM2/IL1B/POSTN/CD2/XBP1/MAPK3/SPTBN1/CRTAM/CD14/LILRA2/PTPN22/F2R/IL17RA/TLR2/TWIST1/NLRP3/GLMN 22 BP GO:0033673 negative regulation of kinase activity 33/1096 257/18670 1.965e-05 0.0003607 0.0002447 TNFAIP3/RHOH/WWTR1/FABP4/ADIPOQ/DUSP5/IL1B/HSPB1/PTPN6/RGN/RGS2/CDKN2C/PTPRC/TRIB2/PAK2/DUSP14/PKIG/PTPN22/CAV3/THY1/UCHL1/BMP4/LRP5/GMFG/APOE/DUSP2/CSK/TFAP4/SFRP1/DUSP3/PTPN2/PLK1/SPRY1 33 BP GO:0014888 striated muscle adaptation 13/1096 57/18670 1.995e-05 0.000365 0.0002476 FOXO1/GSN/SMAD3/TNNT1/MYH7/INPP5F/TNNC1/ACTA1/TNNI1/IGFBP5/HDAC4/CAMTA2/IL15 13 BP GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 9/1096 28/18670 2.003e-05 0.0003654 0.0002478 FCGR2B/LILRB4/PTPN6/PTPN22/THY1/GBP1/LPXN/DUSP3/PTPN2 9 BP GO:0006469 negative regulation of protein kinase activity 31/1096 235/18670 2.041e-05 0.0003711 0.0002517 TNFAIP3/WWTR1/FABP4/ADIPOQ/DUSP5/IL1B/HSPB1/PTPN6/RGN/RGS2/CDKN2C/PTPRC/TRIB2/PAK2/DUSP14/PKIG/PTPN22/CAV3/THY1/UCHL1/BMP4/LRP5/GMFG/APOE/DUSP2/TFAP4/SFRP1/DUSP3/PTPN2/PLK1/SPRY1 31 BP GO:0071496 cellular response to external stimulus 40/1096 339/18670 2.073e-05 0.0003757 0.0002548 FOXO1/LPL/EGFR/TNFRSF10B/AXL/PCK1/ICAM1/IRF1/CD40/DAG1/IL1B/NAMPT/POSTN/XBP1/MAPK3/SIK1/DAP/NFKB1/HSPA5/PTPRC/PDK2/MYD88/ITGA4/COL1A1/GABARAPL1/GAS6/GOT1/PIM1/AQP1/BAD/EHMT2/HDAC4/WDR45/TNFSF14/SFRP1/BNIP3/NPRL3/INHBB/IL15/JUN 40 BP GO:0010631 epithelial cell migration 41/1096 351/18670 2.085e-05 0.0003767 0.0002555 CXCL13/MECP2/ANGPT1/LOXL2/SEMA5A/TGFB2/VEGFA/MAPRE2/SEMA3A/EMP2/HBEGF/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/DOCK1/ID1/EGR3/FGFR1/SASH1/PLK2/GATA2/CTSH/KANK1/HIF1A/BMP4/GPX1/PECAM1/CCR6/APOE/PTP4A3/LGMN/NRP2/ITGB2/ANGPT2/PFN2/HYAL1/JUN/AMOT 41 BP GO:0034142 toll-like receptor 4 signaling pathway 10/1096 35/18670 2.222e-05 0.0004001 0.0002714 TNFAIP3/TRIL/NFKBIA/LY96/MFHAS1/CD14/LILRA2/PTPN22/LBP/ITGB2 10 BP GO:1902903 regulation of supramolecular fiber organization 41/1096 352/18670 2.23e-05 0.0004003 0.0002715 MECP2/ARL2/TMOD1/CORO1A/CRYAB/SEMA5A/GSN/ICAM1/BIN1/ARHGEF10/PTK2B/PLEK/SMAD3/CCR7/PAK1/S1PR1/MAPRE3/SPTBN1/CDH5/ID1/HCLS1/CAPG/KANK1/CAV3/AKAP9/CAMSAP2/DLC1/GPX1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/APOE/STMN2/CTTN/ARPC3/CXCL12/ARHGEF5/SFRP1/TENM1/PFN2 41 BP GO:0003205 cardiac chamber development 25/1096 171/18670 2.238e-05 0.0004005 0.0002716 TGFBR3/PARVA/TGFB2/GATA3/RBP4/FZD2/MYL2/MYH10/MYH7/TNNC1/CAV3/SEMA3C/MYL3/SMARCD3/HIF1A/BMP4/TNNI1/UBE4B/DHRS3/BMPR1A/FOXC1/NRP2/NPRL3/SMAD6/RXRA 25 BP GO:0061138 morphogenesis of a branching epithelium 26/1096 182/18670 2.337e-05 0.0004161 0.0002822 VEGFA/SEMA3E/SEMA3A/SIX1/DAG1/SULF1/PAK1/TGM2/MAGED1/AR/FGFR1/DLG5/CTSH/CAV3/SEMA3C/HOXA5/BMP4/LRP5/CTNNBIP1/SFRP1/SPINT2/HOXA11/ST14/SPRY1/RXRA/COL4A1 26 BP GO:0032635 interleukin-6 production 24/1096 161/18670 2.34e-05 0.0004161 0.0002822 TNFAIP3/ZBTB20/LPL/CD200/IL1RN/LILRB2/IL1B/SLAMF1/XBP1/PTPN6/IL27RA/PTAFR/LILRA2/MYD88/GAS6/PTPN22/F2R/NCKAP1L/TLR2/MAPK13/LBP/CSK/TWIST1/INPP5D 24 BP GO:0010718 positive regulation of epithelial to mesenchymal transition 12/1096 50/18670 2.395e-05 0.0004247 0.000288 LOXL2/WWTR1/TGFB2/TCF7L2/IL1B/SMAD3/PDPN/COL1A1/OLFM1/BMP4/TWIST1/FOXC1 12 BP GO:0010810 regulation of cell-substrate adhesion 29/1096 215/18670 2.455e-05 0.000434 0.0002943 DDR2/RAC2/ARL2/VEGFA/SPOCK2/EPHA3/SEMA3E/EMP2/PTK2B/DAG1/POSTN/SMAD3/CCR7/DOCK1/PDPN/COL1A1/SKAP1/KANK1/THY1/DLC1/ITGA5/EFNA5/FZD7/GBP1/NINJ1/SERPINE1/SFRP1/DUSP3/ANGPT2 29 BP GO:0098869 cellular oxidant detoxification 18/1096 102/18670 2.47e-05 0.0004352 0.0002952 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/GCH1/RGN/S100A9/FBLN5/GPX1/NQO1/FANCC/APOE/LPO/GSTT1/PRDX2/HBE1 18 BP GO:0051258 protein polymerization 35/1096 283/18670 2.504e-05 0.0004398 0.0002983 MECP2/ARL2/TMOD1/CORO1A/GSN/ICAM1/BIN1/PTK2B/GPX4/CCR7/PAK1/MAPRE3/SPTBN1/CDH5/CASQ2/HCLS1/CAPG/KANK1/CAV3/AKAP9/PINK1/CAMSAP2/GMFG/NCKAP1/NCKAP1L/MX2/RHOBTB1/STMN2/CTTN/ARPC3/PSTPIP1/COBL/TENM1/TUBGCP4/PFN2 35 BP GO:0090132 epithelium migration 41/1096 354/18670 2.547e-05 0.0004454 0.0003021 CXCL13/MECP2/ANGPT1/LOXL2/SEMA5A/TGFB2/VEGFA/MAPRE2/SEMA3A/EMP2/HBEGF/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/DOCK1/ID1/EGR3/FGFR1/SASH1/PLK2/GATA2/CTSH/KANK1/HIF1A/BMP4/GPX1/PECAM1/CCR6/APOE/PTP4A3/LGMN/NRP2/ITGB2/ANGPT2/PFN2/HYAL1/JUN/AMOT 41 BP GO:0045088 regulation of innate immune response 49/1096 452/18670 2.551e-05 0.0004454 0.0003021 FCN1/TNFAIP3/CCL5/ADAM8/IFNAR2/RELB/RASGRP1/CLEC10A/CD226/IRF1/AIM2/BIRC3/SH2D1A/FCGR2B/RFTN1/PAK1/TRIL/PTPN6/NFKBIA/S100A9/NFKB1/LY96/MFHAS1/CRTAM/CD14/CTSL/LILRA2/MYD88/PLSCR1/PLCG2/PAK2/PTPN22/NMI/LAG3/GRAMD4/TLR2/STAT1/APOE/IRF7/LBP/VAV1/TRAF3/LGMN/ITGB2/PTPN2/NRAS/IKBKG/IKBKE/TYRO3 49 BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 26/1096 183/18670 2.575e-05 0.0004481 0.0003039 LITAF/ADIPOQ/TNFRSF10B/IL1RN/PRKCB/BIRC3/CD40/IL1B/CCR7/TGM2/SLC20A1/TNFSF10/SECTM1/MID2/MYD88/CX3CR1/PLK2/S100A13/F2R/PINK1/PIM2/PPM1A/EEF1D/IKBKG/IKBKE/VAPA 26 BP GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 19/1096 112/18670 2.642e-05 0.0004557 0.0003091 CCL5/ITGAV/NTRK3/DAG1/SMAD3/INSR/PC/CXCL6/HDAC1/AQP1/PF4/BAD/APOE/APCS/TFAP4/RXRA/VAPA/ELANE/JUN 19 BP GO:0060419 heart growth 19/1096 112/18670 2.642e-05 0.0004557 0.0003091 TGFBR3/TGFB2/SORBS2/PAK1/S1PR1/RBP4/RGS2/SMAD1/FGFR1/CAV3/PIN1/PIM1/CCNB1/BASP1/BMPR1A/PDLIM5/JARID2/FOXC1/RXRA 19 BP GO:1990748 cellular detoxification 19/1096 112/18670 2.642e-05 0.0004557 0.0003091 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/GCH1/RGN/S100A9/FBLN5/GPX1/NQO1/AKR1B10/FANCC/APOE/LPO/GSTT1/PRDX2/HBE1 19 BP GO:0002693 positive regulation of cellular extravasation 7/1096 17/18670 2.722e-05 0.0004681 0.0003175 ADAM8/ICAM1/PTAFR/ITGA4/CCR2/THY1/ELANE 7 BP GO:0051346 negative regulation of hydrolase activity 50/1096 466/18670 2.779e-05 0.0004747 0.000322 SERPINE2/ARL2/CRYAB/RHOH/TGFB2/VEGFA/GCHFR/SPOCK2/SLPI/SERPINA1/TIMP4/BIN1/BIRC3/RARRES1/PLN/RGN/GZMA/APLP2/NOL3/RGS2/CD44/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/APOC1/MGAT5/SERPINB8/LAMP3/PPP1R2/GPX1/PLAUR/MAPK7/AQP1/NCKAP1L/TIMP3/NGF/SERPINE1/PPP1R1A/APCS/TNFSF14/SPINT2/TFPI2/RIMBP2/SPRY1/HERPUD1/AMOT 50 BP GO:0010951 negative regulation of endopeptidase activity 32/1096 250/18670 2.782e-05 0.0004747 0.000322 SERPINE2/CRYAB/VEGFA/SPOCK2/SLPI/SERPINA1/TIMP4/BIN1/BIRC3/RARRES1/APLP2/NOL3/CD44/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/LAMP3/GPX1/PLAUR/AQP1/TIMP3/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2/HERPUD1 32 BP GO:0048747 muscle fiber development 14/1096 67/18670 2.786e-05 0.0004747 0.000322 VEGFA/SIX1/MYL2/MYH11/MYOM2/UCHL1/ACTA1/BMP4/GPX1/TTN/MYBPC2/NEB/HDAC4/MYOM1 14 BP GO:2000377 regulation of reactive oxygen species metabolic process 27/1096 195/18670 2.896e-05 0.000492 0.0003337 FOXO1/RAC2/CRYAB/HBB/EGFR/ICAM1/PTK2B/IL1B/SMAD3/HK2/GCH1/RGN/ASS1/FBLN5/RAB27A/INSR/TRAP1/CX3CR1/HIF1A/PINK1/ZNF205/HDAC4/AGTR1/ITGB2/BNIP3/PRDX2/SLC18A2 27 BP GO:0010742 macrophage derived foam cell differentiation 10/1096 36/18670 2.915e-05 0.0004923 0.0003339 LPL/ITGAV/ADIPOQ/NFKBIA/NFKB1/ABCG1/PF4/STAT1/PRKCH/AGTR1 10 BP GO:0090077 foam cell differentiation 10/1096 36/18670 2.915e-05 0.0004923 0.0003339 LPL/ITGAV/ADIPOQ/NFKBIA/NFKB1/ABCG1/PF4/STAT1/PRKCH/AGTR1 10 BP GO:0010518 positive regulation of phospholipase activity 13/1096 59/18670 2.956e-05 0.0004959 0.0003364 CCL5/P2RY6/EGFR/ITK/NTRK3/PTAFR/FGFR1/NTF3/AGTR1/FGFR3/PDGFRA/S1PR4/FLT1 13 BP GO:0070527 platelet aggregation 13/1096 59/18670 2.956e-05 0.0004959 0.0003364 SERPINE2/HBB/STXBP1/PLEK/HSPB1/PTPN6/PDPN/CSRP1/MYL9/GAS6/PRKG1/PDGFRA/TYRO3 13 BP GO:0043547 positive regulation of GTPase activity 45/1096 405/18670 2.963e-05 0.0004959 0.0003364 PLCB1/ARHGAP12/CCL5/SIPA1L1/CXCL13/CCL13/RGS1/AGAP1/MAPRE2/RASGRP1/ICAM1/CHN1/NTRK3/ARHGEF10/PTK2B/CD40/CCL18/CCR7/S1PR1/DOCK1/RGN/ARHGAP1/RGS2/ARHGAP26/ARHGDIB/PIN1/RAPGEF1/F2R/THY1/DLC1/ACAP1/NTF3/NCKAP1L/TBC1D4/SGSM2/ABR/ARHGAP5/ARHGEF5/VAV1/SFRP1/CCL2/STARD8/NPRL3/CCL7/JUN 45 BP GO:0050729 positive regulation of inflammatory response 23/1096 153/18670 2.998e-05 0.0005003 0.0003393 GPSM3/LPL/ADAM8/FABP4/EGFR/NUPR1/IL1B/CCL18/CCR7/TGM2/NFKBIA/S100A9/CTSC/MYD88/CCR2/IL17RA/PLA2G7/TLR2/SERPINE1/MAPK13/LBP/AGTR1/IL15 23 BP GO:0007568 aging 38/1096 321/18670 3.077e-05 0.000512 0.0003472 TNFRSF1B/LITAF/LOXL2/CRYAB/GSN/HMGA1/PCK1/ICAM1/ADA/AKT3/DAG1/NFKB2/EEF2/NAMPT/GPX4/DNMBP/MAPK3/RGN/ASS1/CTSC/TIMP2/PLK2/ERCC1/IGFBP2/NQO1/ZMIZ1/IGFBP5/BCL2A1/SEC63/SERPINE1/BMPR1A/TWIST1/INPP5D/CARM1/ITGB2/IL15/JUN/MBD2 38 BP GO:0051403 stress-activated MAPK cascade 35/1096 286/18670 3.13e-05 0.0005193 0.0003522 FOXO1/PLCB1/CRYAB/TGFB2/VEGFA/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAPK3/MAP3K4/NFKB1/MFHAS1/CD27/SASH1/PTPN22/CAV3/RAPGEF1/PINK1/MAP4K1/FZD7/MAPK10/MAPK13/ARHGEF5/SFRP1/DUSP3/IKBKG 35 BP GO:0001763 morphogenesis of a branching structure 27/1096 196/18670 3.175e-05 0.0005253 0.0003563 VEGFA/SEMA3E/SEMA3A/SIX1/DAG1/SULF1/PAK1/TGM2/MAGED1/AR/FGFR1/DLG5/CTSH/CAV3/SEMA3C/HOXA5/BMP4/LRP5/RERE/CTNNBIP1/SFRP1/SPINT2/HOXA11/ST14/SPRY1/RXRA/COL4A1 27 BP GO:0032271 regulation of protein polymerization 29/1096 218/18670 3.188e-05 0.0005259 0.0003567 MECP2/ARL2/TMOD1/CORO1A/GSN/ICAM1/BIN1/PTK2B/CCR7/PAK1/MAPRE3/SPTBN1/CDH5/HCLS1/CAPG/KANK1/CAV3/AKAP9/PINK1/CAMSAP2/GMFG/NCKAP1/NCKAP1L/RHOBTB1/STMN2/CTTN/ARPC3/TENM1/PFN2 29 BP GO:0002064 epithelial cell development 28/1096 207/18670 3.197e-05 0.0005259 0.0003567 CXCR4/MAGI2/TMOD1/VEGFA/ADIPOQ/ICAM1/FLNB/ATRX/STC1/IL1B/SDC1/XBP1/CDH5/ID1/AR/FGFR1/ACTA2/RAPGEF1/HOXA5/HIF1A/BMP4/GPX1/PECAM1/BAD/LAMB2/FOSL2/SPINT2/ST14 28 BP GO:0071887 leukocyte apoptotic process 18/1096 104/18670 3.239e-05 0.0005312 0.0003603 CCL5/ADAM8/IL7R/AXL/ADA/CCR7/CCR5/CTSL/CD3G/CD27/HCLS1/GAS6/HIF1A/BMP4/KDELR1/IRF7/CXCL12/IL2RA 18 BP GO:0030218 erythrocyte differentiation 19/1096 114/18670 3.41e-05 0.0005577 0.0003783 TGFBR3/VEGFA/THRA/GATA3/MFHAS1/HCLS1/MB/GATA2/HOXA5/HIF1A/BMP4/NFE2L1/JMJD6/NCKAP1L/IKZF1/STAT1/INPP5D/PTPN2/TRIM58 19 BP GO:2000404 regulation of T cell migration 11/1096 44/18670 3.462e-05 0.0005645 0.0003829 CCL5/ADAM8/CXCL13/CD200/IL27RA/ITGA4/CCR2/CCR6/CXCL10/CXCL12/TNFSF14 11 BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 20/1096 124/18670 3.492e-05 0.0005662 0.0003841 SERPINE2/CCL5/ANGPT1/TGFB2/EGFR/RASGRP1/PTPN13/NTRK3/PIP4K2B/MAPK3/PTPN6/INSR/HCLS1/FGFR1/F2R/NTF3/TWIST1/PDGFRA/SELP/FLT1 20 BP GO:0050670 regulation of lymphocyte proliferation 28/1096 208/18670 3.492e-05 0.0005662 0.0003841 TNFRSF1B/CCL5/RAC2/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/DLG5/CCR2/PTPN22/BMP4/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/INPP5D/TFRC/IL2RA/IL15/GLMN 28 BP GO:0055017 cardiac muscle tissue growth 18/1096 105/18670 3.698e-05 0.0005947 0.0004033 TGFBR3/TGFB2/SORBS2/PAK1/S1PR1/RBP4/RGS2/SMAD1/FGFR1/CAV3/PIN1/PIM1/CCNB1/BMPR1A/PDLIM5/JARID2/FOXC1/RXRA 18 BP GO:1903707 negative regulation of hemopoiesis 23/1096 155/18670 3.699e-05 0.0005947 0.0004033 RUNX3/IL4R/ZBTB16/ADIPOQ/IRF1/PTK2B/TCTA/FCGR2B/LILRB4/NFKBIA/GATA2/PAF1/HOXA5/BMP4/LAG3/PF4/LILRB3/APCS/INPP5D/SFRP1/PTPN2/CUL4A/PRDX2 23 BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 23/1096 155/18670 3.699e-05 0.0005947 0.0004033 TNFAIP3/ITGAV/TNFRSF10B/ICAM1/TCF7L2/IL1B/NOL3/TNFSF10/PTPRC/TRAF1/PAK2/AR/FGFR1/G0S2/BMP4/GPX1/MAPK7/TIMP3/PF4/SERPINE1/CTTN/SFRP1/PRDX2 23 BP GO:0010743 regulation of macrophage derived foam cell differentiation 9/1096 30/18670 3.73e-05 0.0005963 0.0004044 LPL/ITGAV/ADIPOQ/NFKBIA/NFKB1/ABCG1/PF4/PRKCH/AGTR1 9 BP GO:0071549 cellular response to dexamethasone stimulus 9/1096 30/18670 3.73e-05 0.0005963 0.0004044 FOXO1/EGFR/PCK1/ICAM1/ASS1/AQP1/DDIT4/TFAP4/PCK2 9 BP GO:0002526 acute inflammatory response 29/1096 220/18670 3.781e-05 0.0006019 0.0004083 ADAM8/CFB/ICAM1/SERPINA1/GATA3/FCGR2B/NUPR1/IL1B/CCR7/ADORA1/ASS1/DNASE1L3/CFP/PLSCR1/IGKC/CFI/PHB/F8/CTNNBIP1/IGLV6-57/C6/LBP/NLRP3/APCS/SAA4/IGLC1/C7/C3AR1/ELANE 29 BP GO:2000403 positive regulation of lymphocyte migration 10/1096 37/18670 3.786e-05 0.0006019 0.0004083 CCL5/ADAM8/CXCL13/PTK2B/ITGA4/CCR2/CXCL10/CXCL12/TNFSF14/CCL7 10 BP GO:0031099 regeneration 27/1096 198/18670 3.807e-05 0.0006026 0.0004087 SPP1/TGFBR3/GSN/EGFR/AXL/SGCA/LCP1/NTRK3/DAG1/POSTN/RGN/CCND1/GAS6/INPP5F/THY1/CCNA2/GPX1/CDK4/FZD7/CCNB1/NINJ1/CXCL12/PTPRF/LAMB2/ANGPT2/JUN/GAP43 27 BP GO:0032944 regulation of mononuclear cell proliferation 28/1096 209/18670 3.812e-05 0.0006026 0.0004087 TNFRSF1B/CCL5/RAC2/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/DLG5/CCR2/PTPN22/BMP4/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/INPP5D/TFRC/IL2RA/IL15/GLMN 28 BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 22/1096 145/18670 3.833e-05 0.0006026 0.0004087 CD247/CD226/FCGR2B/PAK1/MAPK3/DOCK1/PTPRC/MYH2/PLSCR1/PLCG2/CD3G/RAPGEF1/FCGR2A/IGKC/NCKAP1/NCKAP1L/IGLV6-57/ARPC3/CSK/VAV1/IGLC1/CYFIP2 22 BP GO:0071901 negative regulation of protein serine/threonine kinase activity 22/1096 145/18670 3.833e-05 0.0006026 0.0004087 TNFAIP3/ADIPOQ/DUSP5/IL1B/HSPB1/PTPN6/RGS2/CDKN2C/DUSP14/PKIG/PTPN22/CAV3/UCHL1/BMP4/LRP5/APOE/DUSP2/TFAP4/SFRP1/DUSP3/PLK1/SPRY1 22 BP GO:1901653 cellular response to peptide 43/1096 385/18670 3.912e-05 0.0006134 0.000416 FOXO1/LPL/RARRES2/SH2B2/ADIPOQ/PCK1/ICAM1/ENPP1/PRKCB/FCGR2B/IL1B/AKR1B1/NAMPT/BCL2L2/PAK1/ADCY9/XBP1/ASS1/NFKB1/PDK2/LDOC1/ITGA4/INSR/ID1/ADCY6/PTPN22/CASP4/KANK1/GOT1/CCNA2/CDK4/TBC1D4/STAT1/CSK/AGTR1/LGMN/PTPN2/INHBB/ATP6V0D1/PTPRE/PCK2/CDC6/ADCY1 43 BP GO:0045471 response to ethanol 20/1096 125/18670 3.931e-05 0.0006147 0.0004169 GSN/ADIPOQ/ICAM1/GATA3/NTRK3/PTK2B/EEF2/RBP4/GOT2/CCND1/RGS2/CD14/CD27/OXCT1/CDO1/NQO1/BAD/USP46/CA3/CCL7 20 BP GO:0001959 regulation of cytokine-mediated signaling pathway 25/1096 177/18670 4.04e-05 0.0006299 0.0004272 TNFAIP3/CXCR4/CCL5/IFNAR2/ANGPT1/ADIPOQ/AXL/PXDN/IL1RN/BIRC3/CPNE1/PTPN6/NOL3/PTPRC/TRAF1/GAS6/CASP4/HIF1A/STAT1/IRF7/AGPAT1/PTPN2/LIFR/IKBKG/IKBKE 25 BP GO:0043407 negative regulation of MAP kinase activity 15/1096 78/18670 4.1e-05 0.0006375 0.0004324 ADIPOQ/DUSP5/IL1B/PTPN6/RGS2/DUSP14/PTPN22/CAV3/UCHL1/BMP4/APOE/DUSP2/SFRP1/DUSP3/SPRY1 15 BP GO:0048739 cardiac muscle fiber development 7/1096 18/18670 4.229e-05 0.0006541 0.0004436 VEGFA/MYH11/MYOM2/BMP4/TTN/MYBPC2/MYOM1 7 BP GO:0090026 positive regulation of monocyte chemotaxis 7/1096 18/18670 4.229e-05 0.0006541 0.0004436 CCL5/CCR2/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN 7 BP GO:0051250 negative regulation of lymphocyte activation 22/1096 146/18670 4.268e-05 0.0006582 0.0004464 RUNX3/TNFAIP3/IL4R/AXL/LILRB2/IRF1/FCGR2B/PTPN6/DLG5/PTPN22/BMP4/PARP3/LAG3/CD86/INPP5D/SFRP1/DUSP3/PTPN2/IL2RA/PRDX2/TYRO3/GLMN 22 BP GO:0009615 response to virus 38/1096 326/18670 4.324e-05 0.000664 0.0004504 TNFAIP3/CXCR4/CCL5/IFNAR2/HMGA1/IRF1/GATA3/AIM2/DCLK1/BIRC3/CD40/IL1B/HSPB1/PTPRC/PLSCR1/ISG20/ACTA2/PCBP2/BAD/MX2/HTRA1/PIM2/STAT1/GBP1/CXCL10/G3BP1/IRF7/DDIT4/CXCL12/NLRP3/TRAF3/IL2RA/BNIP3/OAS2/IKBKG/IKBKE/HYAL1/IL15 38 BP GO:0050769 positive regulation of neurogenesis 50/1096 474/18670 4.33e-05 0.000664 0.0004504 CREB3L2/TNFRSF1B/SERPINE2/CXCR4/MAGI2/SEMA5A/VEGFA/CDON/EPHA3/SEMA3A/NTRK3/BIN1/PTK2B/ZNF365/CPNE1/CUX1/DAG1/IL1B/SHANK2/PAK1/NEDD4L/S100A9/RGS2/HSPA5/CRX/CX3CR1/FGFR1/DLG5/TIMP2/GATA2/SYT17/CCR2/RAPGEF1/SMARCD3/HIF1A/ASPA/BMP4/EFNA5/HDAC1/MMD/TLR2/APOE/NGF/PLXNC1/PRKCH/STMN2/PLXNA2/CXCL12/SPEN/COBL 50 BP GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 8/1096 24/18670 4.341e-05 0.000664 0.0004504 LCK/CD226/ADA/PRKCB/CCR7/PTPRC/RAB29/PRKCH 8 BP GO:0032479 regulation of type I interferon production 20/1096 126/18670 4.42e-05 0.0006743 0.0004574 TNFAIP3/ZBTB20/RELB/IRF1/NFKB2/NFKB1/CD14/MYD88/PLCG2/PTPN22/PIN1/NMI/POLR2E/PCBP2/TLR2/STAT1/IRF7/TRAF3/POLR1C/IKBKE 20 BP GO:0006968 cellular defense response 12/1096 53/18670 4.471e-05 0.0006787 0.0004603 LILRB2/ITK/PTK2B/SH2D1A/CCR5/LY96/CX3CR1/CCR2/CCR6/GNLY/LBP/NCF2 12 BP GO:0070663 regulation of leukocyte proliferation 29/1096 222/18670 4.472e-05 0.0006787 0.0004603 TNFAIP3/TNFRSF1B/CCL5/RAC2/CORO1A/LILRB2/ADA/IRF1/CD40/FCGR2B/IL1B/PTPN6/GPR183/CD38/PTPRC/DLG5/CCR2/PTPN22/BMP4/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/INPP5D/TFRC/IL2RA/IL15/GLMN 29 BP GO:0001657 ureteric bud development 17/1096 97/18670 4.512e-05 0.0006829 0.0004632 VEGFA/SIX1/GATA3/SMAD3/SDC1/MAGED1/SMAD1/FGFR1/BMP4/BASP1/CTNNBIP1/FOXC1/SFRP1/HOXA11/SPRY1/SMAD6/CRLF1 17 BP GO:0010517 regulation of phospholipase activity 14/1096 70/18670 4.667e-05 0.0007045 0.0004778 CCL5/P2RY6/EGFR/ITK/NTRK3/PTAFR/RGS2/FGFR1/NTF3/AGTR1/FGFR3/PDGFRA/S1PR4/FLT1 14 BP GO:1990138 neuron projection extension 24/1096 168/18670 4.748e-05 0.0007149 0.0004849 CXCR4/SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/DCLK1/CPNE1/POSTN/AUTS2/PAK1/NEDD4L/ITGA4/OLFM1/SYT17/SEMA3C/SEMA4F/APOE/CTTN/CXCL12/LAMB2/NRP2/DPYSL2/CYFIP2 24 BP GO:0043502 regulation of muscle adaptation 18/1096 107/18670 4.792e-05 0.0007196 0.0004881 FOXO1/TNFRSF1B/SGCA/DAG1/SMAD3/PAK1/TNNT1/NOL3/RGS2/MYH7/TNNC1/CAV3/PIN1/TNNI1/IGFBP5/PDE9A/HDAC4/JARID2 18 BP GO:0048771 tissue remodeling 25/1096 179/18670 4.882e-05 0.0007312 0.0004959 SPP1/TNFAIP3/ADAM8/RAC2/EGFR/AXL/PTK2B/S1PR1/TGM2/NOL3/CD38/CCR2/SEMA3C/HIF1A/F2R/LRP5/IGFBP5/CSK/ABR/THBS4/INPP5D/FOXC1/TFRC/SFRP1/IL15 25 BP GO:0032835 glomerulus development 13/1096 62/18670 5.151e-05 0.0007634 0.0005178 MAGI2/ANGPT1/WWTR1/ADIPOQ/SULF1/ACTA2/BMP4/PECAM1/BASP1/LAMB2/FOXC1/ANGPT2/PDGFRA 13 BP GO:0060191 regulation of lipase activity 17/1096 98/18670 5.165e-05 0.0007634 0.0005178 LPL/CCL5/P2RY6/EGFR/ITK/NTRK3/PTAFR/RGS2/LIPC/FGFR1/APOC1/NTF3/AGTR1/FGFR3/PDGFRA/S1PR4/FLT1 17 BP GO:0072163 mesonephric epithelium development 17/1096 98/18670 5.165e-05 0.0007634 0.0005178 VEGFA/SIX1/GATA3/SMAD3/SDC1/MAGED1/SMAD1/FGFR1/BMP4/BASP1/CTNNBIP1/FOXC1/SFRP1/HOXA11/SPRY1/SMAD6/CRLF1 17 BP GO:0072164 mesonephric tubule development 17/1096 98/18670 5.165e-05 0.0007634 0.0005178 VEGFA/SIX1/GATA3/SMAD3/SDC1/MAGED1/SMAD1/FGFR1/BMP4/BASP1/CTNNBIP1/FOXC1/SFRP1/HOXA11/SPRY1/SMAD6/CRLF1 17 BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 17/1096 98/18670 5.165e-05 0.0007634 0.0005178 BCL2L2/XBP1/HSPB1/NOL3/CD44/TRAP1/HIF1A/PINK1/GPX1/PLAUR/MAPK7/HDAC1/BCL2A1/CXCL12/WFS1/HERPUD1/PTTG1IP 17 BP GO:0048660 regulation of smooth muscle cell proliferation 24/1096 169/18670 5.232e-05 0.0007714 0.0005232 TNFAIP3/CCL5/P2RY6/PDE1A/EGFR/ADIPOQ/HBEGF/TCF7L2/AKR1B1/NAMPT/PAK1/S1PR1/TGM2/PTAFR/BMP4/IGFBP5/PRKG1/STAT1/CTNNBIP1/HDAC4/BMPR1A/ELANE/IL15/JUN 24 BP GO:0014065 phosphatidylinositol 3-kinase signaling 22/1096 148/18670 5.271e-05 0.0007752 0.0005258 SERPINE2/CCL5/ANGPT1/TGFB2/EGFR/RASGRP1/PTPN13/GATA3/NTRK3/PIP4K2B/MAPK3/PTPN6/INSR/HCLS1/FGFR1/F2R/NTF3/TWIST1/PDGFRA/TYRO3/SELP/FLT1 22 BP GO:0043300 regulation of leukocyte degranulation 11/1096 46/18670 5.405e-05 0.0007908 0.0005364 IL4R/RAC2/STXBP1/FCGR2B/GAB2/PTAFR/GATA2/STXBP2/CCR2/ABR/ITGB2 11 BP GO:0071675 regulation of mononuclear cell migration 11/1096 46/18670 5.405e-05 0.0007908 0.0005364 PLCB1/CCL5/RARRES2/MAPK3/CCR2/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN/C3AR1 11 BP GO:0043433 negative regulation of DNA-binding transcription factor activity 24/1096 170/18670 5.76e-05 0.0008405 0.0005701 TNFAIP3/NFKBIE/CD200/AIM2/NUPR1/TCF7L2/ADORA3/SIK1/SFRP4/ID3/DAP/NFKBIA/ID1/GAS6/PIM1/TNFRSF4/USP7/CTNNBIP1/HDAC4/TWIST1/NLRP3/TRAF3/WFS1/PRDX2 24 BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 22/1096 149/18670 5.848e-05 0.0008512 0.0005773 GSN/TNFRSF10B/LCK/AIM2/SMAD3/CTSD/DAP/S100A9/TNFSF10/ASPH/CTSH/CASP4/F2R/DLC1/HIP1/BAD/GRAMD4/NGF/NLRP3/TFAP4/LGMN/CYFIP2 22 BP GO:0022408 negative regulation of cell-cell adhesion 25/1096 181/18670 5.88e-05 0.0008536 0.000579 RUNX3/IL4R/SERPINE2/VEGFA/ADIPOQ/IL1RN/LILRB2/IRF1/FCGR2B/PTPN6/ASS1/DLG5/PTPN22/BMP4/MAPK7/LAG3/PRKG1/CD86/CXCL12/DUSP3/PTPN2/IL2RA/SPINT2/PRDX2/GLMN 25 BP GO:0007565 female pregnancy 26/1096 192/18670 5.927e-05 0.0008583 0.0005821 SPP1/EMP2/STC1/IL1B/AKR1B1/NAMPT/MAGED2/ADIPOR2/CLIC5/IGFBP7/MAPK3/PAM/GOT2/CD38/RGS2/LDOC1/PTHLH/ARHGDIB/AR/ITGA5/IGFBP2/IGFBP5/HSD11B2/ANGPT2/STS/RXRA 26 BP GO:0032872 regulation of stress-activated MAPK cascade 30/1096 237/18670 6.029e-05 0.0008709 0.0005907 FOXO1/PLCB1/TGFB2/VEGFA/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAPK3/MAP3K4/MFHAS1/CD27/SASH1/PTPN22/CAV3/RAPGEF1/PINK1/MAP4K1/FZD7/ARHGEF5/SFRP1/DUSP3 30 BP GO:0002700 regulation of production of molecular mediator of immune response 21/1096 139/18670 6.078e-05 0.0008757 0.0005939 TNFRSF1B/IL4R/ANGPT1/TGFB2/CD226/GATA3/CD40/FCGR2B/IL1B/TP53BP1/RBP4/XBP1/MAPK3/TRIL/IL27RA/PTPRC/CCR2/PARP3/TNFRSF4/NLRP3/TFRC 21 BP GO:0007409 axonogenesis 49/1096 468/18670 6.212e-05 0.0008928 0.0006055 SPP1/UST/CXCR4/SIPA1L1/RAC2/EGR2/SEMA5A/STXBP1/VEGFA/EPHA3/SEMA3E/SEMA3A/ANK3/CHN1/NFIB/GATA3/NTRK3/DCLK1/GFRA2/DAG1/AUTS2/PAK1/MAPK3/GAB2/SPTBN1/MYH10/ITGA4/OLFM1/SEMA3C/UNC5C/THY1/SEMA4F/UCHL1/EFNA5/MAPK7/APOE/NGF/PLXNC1/CTTN/PLXNA2/CXCL12/LAMB2/CDH2/NRP2/COBL/DPYSL2/CYFIP2/ADCY1/GAP43 49 BP GO:0001656 metanephros development 16/1096 90/18670 6.267e-05 0.0008961 0.0006078 WWTR1/ADIPOQ/SIX1/GATA3/AKR1B1/ID3/DLG5/CTSH/BMP4/BASP1/STAT1/LAMB2/OSR2/PDGFRA/HOXA11/SPRY1 16 BP GO:0010717 regulation of epithelial to mesenchymal transition 16/1096 90/18670 6.267e-05 0.0008961 0.0006078 LOXL2/WWTR1/TGFB2/EPHA3/DAG1/TCF7L2/IL1B/SMAD3/PDPN/COL1A1/OLFM1/LDLRAD4/BMP4/TWIST1/FOXC1/SFRP1 16 BP GO:0010634 positive regulation of epithelial cell migration 24/1096 171/18670 6.335e-05 0.0009001 0.0006105 ANGPT1/SEMA5A/TGFB2/VEGFA/MAPRE2/HBEGF/AKT3/GATA3/PTK2B/CD40/HSPB1/DOCK1/FGFR1/SASH1/PLK2/GATA2/CTSH/HIF1A/BMP4/CCR6/LGMN/NRP2/HYAL1/JUN 24 BP GO:0048659 smooth muscle cell proliferation 24/1096 171/18670 6.335e-05 0.0009001 0.0006105 TNFAIP3/CCL5/P2RY6/PDE1A/EGFR/ADIPOQ/HBEGF/TCF7L2/AKR1B1/NAMPT/PAK1/S1PR1/TGM2/PTAFR/BMP4/IGFBP5/PRKG1/STAT1/CTNNBIP1/HDAC4/BMPR1A/ELANE/IL15/JUN 24 BP GO:0002313 mature B cell differentiation involved in immune response 7/1096 19/18670 6.358e-05 0.0009001 0.0006105 ADA/PTK2B/FCGR2B/XBP1/GPR183/PLCG2/LFNG 7 BP GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 7/1096 19/18670 6.358e-05 0.0009001 0.0006105 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0045089 positive regulation of innate immune response 42/1096 381/18670 6.473e-05 0.0009099 0.0006172 FCN1/TNFAIP3/CCL5/ADAM8/RELB/RASGRP1/CLEC10A/CD226/IRF1/AIM2/BIRC3/SH2D1A/RFTN1/PAK1/TRIL/NFKBIA/S100A9/NFKB1/LY96/MFHAS1/CRTAM/CD14/CTSL/LILRA2/MYD88/PLSCR1/PLCG2/PAK2/PTPN22/LAG3/GRAMD4/TLR2/IRF7/LBP/VAV1/TRAF3/LGMN/ITGB2/NRAS/IKBKG/IKBKE/TYRO3 42 BP GO:0008360 regulation of cell shape 22/1096 150/18670 6.481e-05 0.0009099 0.0006172 PARVA/CORO1A/CCL13/RHOH/VEGFA/SEMA3E/ICAM1/PTK2B/DAG1/RHOBTB3/DNMBP/MYH10/PDPN/FAM171A1/S100A13/DLC1/PLXNC1/PLXNA2/ITGB2/CCL2/CCL7/ALDOA 22 BP GO:0034109 homotypic cell-cell adhesion 15/1096 81/18670 6.481e-05 0.0009099 0.0006172 SERPINE2/CCL5/HBB/STXBP1/ANK3/PLEK/HSPB1/PTPN6/PDPN/CSRP1/MYL9/GAS6/PRKG1/PDGFRA/TYRO3 15 BP GO:0051091 positive regulation of DNA-binding transcription factor activity 32/1096 261/18670 6.491e-05 0.0009099 0.0006172 DDR2/ADAM8/VEGFA/CD200/ICAM1/PRKCB/AIM2/CD40/NFKB2/IL1B/TP53BP1/SMAD3/FZD2/S100A9/NFKB1/TRAF1/MID2/MYD88/HCLS1/CX3CR1/AR/PINK1/ERC1/TLR2/PRKCH/HDAC4/NLRP3/ARHGEF5/CARM1/ITGB2/IKBKG/ADCY1 32 BP GO:0042737 drug catabolic process 21/1096 140/18670 6.762e-05 0.0009439 0.0006402 MAOA/HBB/PXDN/FAH/PCK1/ADA/GPX3/HPD/AMPD3/OXCT1/CTSH/ALDH3B1/PCBD1/MOXD1/GPX1/QDPR/LPO/SDS/PRDX2/PCK2/HBE1 21 BP GO:0051348 negative regulation of transferase activity 34/1096 285/18670 6.767e-05 0.0009439 0.0006402 TNFAIP3/RHOH/WWTR1/FABP4/ADIPOQ/DUSP5/IL1B/HSPB1/PTPN6/RGN/RGS2/CDKN2C/PTPRC/TRIB2/PAK2/DUSP14/PKIG/PTPN22/CAV3/THY1/UCHL1/BMP4/PARP3/LRP5/GMFG/APOE/DUSP2/CSK/TFAP4/SFRP1/DUSP3/PTPN2/PLK1/SPRY1 34 BP GO:0016042 lipid catabolic process 38/1096 333/18670 6.846e-05 0.0009526 0.0006461 SPP1/PLCB1/LPL/RARRES2/FABP4/ECH1/ADIPOQ/PCK1/PLIN1/THRA/IL1B/ADORA1/CRAT/ECI1/PNPLA6/ECHS1/LIPC/PLD3/ACADS/HADH/PLCG2/SLC27A2/PNPLA4/APOC1/INPP5F/ACOX2/CDK4/PLA2G7/AKR1B10/APOE/TWIST1/AOAH/ALDH3A2/PLA2G15/STS/NAGA/PCK2/ETFB 38 BP GO:0030324 lung development 24/1096 172/18670 6.961e-05 0.0009663 0.0006554 VEGFA/EGFR/NFIB/ADA/THRA/DAG1/RBP4/MAPK3/CHI3L1/ADAMTS2/PDPN/ID1/FGFR1/DLG5/CTSH/HOXA5/BMP4/JMJD6/IGFBP5/BMPR1A/SIM2/PDGFRA/SPRY1/ADAMTSL2 24 BP GO:0010466 negative regulation of peptidase activity 32/1096 262/18670 6.989e-05 0.0009677 0.0006563 SERPINE2/CRYAB/VEGFA/SPOCK2/SLPI/SERPINA1/TIMP4/BIN1/BIRC3/RARRES1/APLP2/NOL3/CD44/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/LAMP3/GPX1/PLAUR/AQP1/TIMP3/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2/HERPUD1 32 BP GO:0022612 gland morphogenesis 19/1096 120/18670 7.04e-05 0.0009711 0.0006587 TNFAIP3/TGFB2/EGFR/SEMA3A/NFIB/DAG1/SULF1/XBP1/TGM2/AR/FGFR1/CAV3/SEMA3C/ID4/BMP4/LRP5/IGFBP5/SFRP1/RXRA 19 BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 30/1096 239/18670 7.047e-05 0.0009711 0.0006587 FOXO1/PLCB1/TGFB2/VEGFA/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAPK3/MAP3K4/MFHAS1/CD27/SASH1/PTPN22/CAV3/RAPGEF1/PINK1/MAP4K1/FZD7/ARHGEF5/SFRP1/DUSP3 30 BP GO:0045638 negative regulation of myeloid cell differentiation 16/1096 91/18670 7.196e-05 0.0009891 0.0006709 ZBTB16/ADIPOQ/PTK2B/TCTA/LILRB4/NFKBIA/GATA2/PAF1/HOXA5/PF4/LILRB3/APCS/INPP5D/SFRP1/PTPN2/CUL4A 16 BP GO:0044262 cellular carbohydrate metabolic process 34/1096 286/18670 7.258e-05 0.0009953 0.000675 FOXO1/MECP2/P2RY6/ADIPOQ/PPP1R3C/PCK1/ENPP1/PTK2B/NUPR1/AKR1B1/PLEK/HK2/SLC5A3/SIK1/GK/RGN/PYGM/PTAFR/PYGB/PDK2/INSR/DYRK2/GOT1/PPP1R2/NFE2L1/BAD/PGD/PPP1R1A/PHLDA2/HDAC4/DDIT4/AOAH/PTPN2/PCK2 34 BP GO:0050808 synapse organization 44/1096 408/18670 7.344e-05 0.001005 0.0006814 MAGI2/SIPA1L1/MECP2/SPOCK2/SEMA3E/ANK3/LILRB2/CLSTN1/SIX1/NDRG1/NTRK3/ZNF365/THBS2/FCGR2B/DAG1/ACTN1/SHANK2/PDZRN3/MYH10/RAB29/INSR/SPARCL1/CX3CR1/DLG5/PIN1/F2R/EFNA5/UNC13B/NFIA/TLR2/SNCG/APOE/GLRB/PCDH17/CTTN/PDLIM5/PTPRF/LAMB2/LGMN/CDH2/NRP2/PFN2/COL4A1/GAP43 44 BP GO:0043393 regulation of protein binding 28/1096 217/18670 7.48e-05 0.001021 0.0006924 TGFBR3/DZIP1/ANGPT1/CDON/ADIPOQ/SLPI/TCF7L2/MAPK3/MAPRE3/HSPA5/LDOC1/ITGA4/ID1/PLK2/PIN1/SMARCD3/PCBD1/BMP4/LFNG/PIM2/APOE/CTNNBIP1/PHLDA2/HDAC4/PTPRF/CARM1/PLK1/TFIP11 28 BP GO:0032637 interleukin-8 production 15/1096 82/18670 7.507e-05 0.001022 0.0006933 FCN1/ADIPOQ/IL1B/CD2/CHI3L1/PTPRC/CD14/LILRA2/MYD88/PTPN22/F2R/TLR2/SERPINE1/LBP/ELANE 15 BP GO:0048661 positive regulation of smooth muscle cell proliferation 17/1096 101/18670 7.651e-05 0.001039 0.0007049 CCL5/P2RY6/EGFR/HBEGF/AKR1B1/NAMPT/PAK1/S1PR1/TGM2/PTAFR/BMP4/IGFBP5/STAT1/HDAC4/BMPR1A/ELANE/JUN 17 BP GO:0042098 T cell proliferation 25/1096 184/18670 7.72e-05 0.001046 0.0007095 TNFRSF1B/CCL5/RAC2/CORO1A/LILRB2/IRF1/IL1B/PTPN6/PTPRC/DLG5/CCR2/BMP4/IGFBP2/ELF4/TNFRSF4/NCKAP1L/SATB1/HLA-DMB/CD86/TFRC/TNFSF14/IL2RA/PRDX2/IL15/GLMN 25 BP GO:0098754 detoxification 20/1096 131/18670 7.768e-05 0.00105 0.0007122 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/GCH1/RGN/S100A9/FBLN5/MT1G/GPX1/NQO1/AKR1B10/FANCC/APOE/LPO/GSTT1/PRDX2/HBE1 20 BP GO:0071548 response to dexamethasone 10/1096 40/18670 7.845e-05 0.001058 0.0007176 FOXO1/EGFR/PCK1/ICAM1/ASS1/PTAFR/AQP1/DDIT4/TFAP4/PCK2 10 BP GO:1904019 epithelial cell apoptotic process 18/1096 111/18670 7.874e-05 0.001059 0.0007185 TNFAIP3/ANGPT1/SEMA5A/GSN/ICAM1/GATA3/CD40/NUPR1/TCF7L2/SFRP4/ITGA4/GAS6/GATA2/MAPK7/BAD/SERPINE1/CCL2/WFS1 18 BP GO:0002523 leukocyte migration involved in inflammatory response 6/1096 14/18670 8.058e-05 0.001082 0.0007336 ADAM8/S100A9/CCR6/LBP/ITGB2/ELANE 6 BP GO:0010001 glial cell differentiation 28/1096 218/18670 8.113e-05 0.001086 0.0007369 TNFRSF1B/SERPINE2/CXCR4/EGR2/GSN/EGFR/NDRG1/NFIB/NTRK3/BIN1/ARHGEF10/ZNF365/DAG1/IL1B/MAPK3/CDKN2C/MXRA8/ASPA/ID4/TSPAN2/NFE2L1/HDAC1/TLR2/CSK/LAMB2/CDH2/BNIP3/GAP43 28 BP GO:0031214 biomineral tissue development 23/1096 163/18670 8.217e-05 0.001093 0.0007412 SPP1/FOXO1/DDR2/SRGN/ENPP1/PTK2B/SMAD3/S1PR1/MGP/NELL1/SLC20A1/ALPL/PTHLH/COL1A1/GAS6/HIF1A/BMP4/MINPP1/BMPR1A/TWIST1/FGFR3/OSR2/TFIP11 23 BP GO:0035272 exocrine system development 11/1096 48/18670 8.218e-05 0.001093 0.0007412 TGFB2/EGFR/SEMA3A/NFIB/DAG1/XBP1/TGM2/INSR/FGFR1/SEMA3C/FOXC1 11 BP GO:0055010 ventricular cardiac muscle tissue morphogenesis 11/1096 48/18670 8.218e-05 0.001093 0.0007412 TGFBR3/TGFB2/MYL2/MYH7/TNNC1/MYL3/TNNI1/UBE4B/BMPR1A/FOXC1/RXRA 11 BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 16/1096 92/18670 8.243e-05 0.001093 0.0007416 CRYAB/VEGFA/BIRC3/NOL3/CD44/CST7/PAK2/CD27/GAS6/LAMP3/GPX1/PLAUR/AQP1/NGF/TNFSF14/HERPUD1 16 BP GO:0034114 regulation of heterotypic cell-cell adhesion 8/1096 26/18670 8.3e-05 0.001093 0.0007416 ADIPOQ/IL1RN/LCK/IL1B/CD44/SKAP1/THY1/MAPK7 8 BP GO:0050926 regulation of positive chemotaxis 8/1096 26/18670 8.3e-05 0.001093 0.0007416 VEGFA/NTRK3/SMAD3/S1PR1/CXCL8/NTF3/CXCL12/ANGPT2 8 BP GO:0055003 cardiac myofibril assembly 8/1096 26/18670 8.3e-05 0.001093 0.0007416 MYL2/MYH10/MYOM2/TTN/MYBPC2/NEB/PDGFRA/MYOM1 8 BP GO:0046328 regulation of JNK cascade 25/1096 185/18670 8.439e-05 0.001109 0.0007523 PLCB1/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAP3K4/MFHAS1/CD27/SASH1/PTPN22/RAPGEF1/PINK1/MAP4K1/FZD7/ARHGEF5/SFRP1/DUSP3 25 BP GO:0010464 regulation of mesenchymal cell proliferation 9/1096 33/18670 8.572e-05 0.001122 0.0007607 VEGFA/SIX1/NFIB/FGFR1/BMP4/LRP5/STAT1/CTNNBIP1/BMPR1A 9 BP GO:2000352 negative regulation of endothelial cell apoptotic process 9/1096 33/18670 8.572e-05 0.001122 0.0007607 TNFAIP3/ANGPT1/SEMA5A/ICAM1/GATA3/GAS6/GATA2/MAPK7/SERPINE1 9 BP GO:0045598 regulation of fat cell differentiation 20/1096 132/18670 8.659e-05 0.001124 0.0007626 FOXO1/ZBTB16/LPL/FTO/RARRES2/WIF1/WWTR1/ADIPOQ/ADIRF/ENPP1/GATA3/SMAD3/XBP1/TRIB2/GATA2/ID4/LRP5/LMO3/CARM1/SFRP1 20 BP GO:0045995 regulation of embryonic development 20/1096 132/18670 8.659e-05 0.001124 0.0007626 PLCB1/ADIPOQ/IL1RN/SIX1/GATA3/DAG1/SULF1/FZD2/INSR/AR/FGFR1/GATA2/BMP4/MAPK7/FZD7/LFNG/PHLDA2/BMPR1A/SFRP1/AMOT 20 BP GO:0048145 regulation of fibroblast proliferation 15/1096 83/18670 8.673e-05 0.001124 0.0007626 DDR2/EGFR/NUPR1/BTC/GAS6/CCNA2/CDK4/CCNB1/ZMIZ1/AQP1/FOSL2/SFRP1/PDGFRA/CDC6/JUN 15 BP GO:2000106 regulation of leukocyte apoptotic process 15/1096 83/18670 8.673e-05 0.001124 0.0007626 CCL5/ADAM8/IL7R/AXL/ADA/CCR7/CCR5/CD3G/CD27/HCLS1/GAS6/HIF1A/BMP4/IRF7/CXCL12 15 BP GO:0007584 response to nutrient 28/1096 219/18670 8.793e-05 0.001137 0.0007714 SPP1/LPL/GSN/EGFR/ADIPOQ/ADA/STC1/IL1B/EEF2/POSTN/ADIPOR2/XBP1/ASS1/CCND1/ALPL/PDK2/COL1A1/OXCT1/GAS6/ERCC1/PIM1/IGFBP2/NQO1/AHCY/STAT1/CXCL10/SFRP1/IL15 28 BP GO:0097193 intrinsic apoptotic signaling pathway 34/1096 289/18670 8.929e-05 0.001152 0.0007815 TNFRSF1B/TNFRSF10B/LCK/NUPR1/BCL2L2/XBP1/HSPB1/S100A9/NOL3/CD44/PDK2/NACC2/TRAP1/CASP4/HIF1A/DYRK2/PINK1/GPX1/ATP2A1/PLAUR/MAPK7/HDAC1/BAD/BCL2A1/MLLT11/DDIT4/CXCL12/PTPN2/BNIP3/WFS1/CUL4A/IKBKE/HERPUD1/PTTG1IP 34 BP GO:1901215 negative regulation of neuron death 27/1096 208/18670 9.007e-05 0.00116 0.0007866 TNFRSF1B/ADAM8/MECP2/ANGPT1/CORO1A/STXBP1/TOX3/CD200/AXL/SIX1/PTK2B/BTG2/CX3CR1/PIN1/HIF1A/F2R/PINK1/NTF3/APOE/NGF/LGMN/CCL2/WFS1/IKBKG/TYRO3/CRLF1/JUN 27 BP GO:0035821 modification of morphology or physiology of other organism 23/1096 164/18670 9.037e-05 0.001161 0.0007874 CCL5/CCL13/ITGAV/SLPI/NTRK3/DAG1/SMAD3/S100A9/INSR/PC/CXCL6/HDAC1/AQP1/PF4/BAD/APOE/GNLY/APCS/TFAP4/RXRA/VAPA/ELANE/JUN 23 BP GO:0050860 negative regulation of T cell receptor signaling pathway 7/1096 20/18670 9.287e-05 0.00119 0.0008074 LILRB4/PTPN6/PTPN22/THY1/GBP1/DUSP3/PTPN2 7 BP GO:0007229 integrin-mediated signaling pathway 17/1096 103/18670 9.845e-05 0.001256 0.0008521 ITGB7/ITGAV/EMP2/PTK2B/ITGAX/PLEK/DST/DOCK1/ITGAL/ITGA4/ITGBL1/THY1/ITGA5/VAV1/ITGB2/COL3A1/LAT 17 BP GO:1902106 negative regulation of leukocyte differentiation 17/1096 103/18670 9.845e-05 0.001256 0.0008521 RUNX3/IL4R/ADIPOQ/IRF1/TCTA/FCGR2B/LILRB4/GATA2/BMP4/LAG3/LILRB3/APCS/INPP5D/SFRP1/PTPN2/CUL4A/PRDX2 17 BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 23/1096 165/18670 9.929e-05 0.001264 0.0008574 LCK/NUPR1/BCL2L2/XBP1/HSPB1/S100A9/NOL3/CD44/NACC2/TRAP1/HIF1A/PINK1/GPX1/PLAUR/MAPK7/HDAC1/BAD/BCL2A1/CXCL12/PTPN2/WFS1/HERPUD1/PTTG1IP 23 BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/1096 84/18670 9.994e-05 0.001266 0.0008587 CRYAB/VEGFA/BIRC3/NOL3/CD44/PAK2/CD27/GAS6/LAMP3/GPX1/PLAUR/AQP1/NGF/TNFSF14/HERPUD1 15 BP GO:0048144 fibroblast proliferation 15/1096 84/18670 9.994e-05 0.001266 0.0008587 DDR2/EGFR/NUPR1/BTC/GAS6/CCNA2/CDK4/CCNB1/ZMIZ1/AQP1/FOSL2/SFRP1/PDGFRA/CDC6/JUN 15 BP GO:0032757 positive regulation of interleukin-8 production 11/1096 49/18670 0.0001004 0.001266 0.0008587 FCN1/ADIPOQ/IL1B/CD2/CD14/MYD88/F2R/TLR2/SERPINE1/LBP/ELANE 11 BP GO:1990090 cellular response to nerve growth factor stimulus 11/1096 49/18670 0.0001004 0.001266 0.0008587 MAGI2/CORO1A/NTRK3/EEF2/HSPA5/ID1/RAPGEF1/NTF3/NGF/STMN2/ARPC3 11 BP GO:0030323 respiratory tube development 24/1096 176/18670 0.0001006 0.001266 0.0008587 VEGFA/EGFR/NFIB/ADA/THRA/DAG1/RBP4/MAPK3/CHI3L1/ADAMTS2/PDPN/ID1/FGFR1/DLG5/CTSH/HOXA5/BMP4/JMJD6/IGFBP5/BMPR1A/SIM2/PDGFRA/SPRY1/ADAMTSL2 24 BP GO:0032273 positive regulation of protein polymerization 20/1096 134/18670 0.0001072 0.001343 0.0009112 MECP2/ARL2/CORO1A/GSN/ICAM1/BIN1/PTK2B/CCR7/PAK1/CAV3/AKAP9/PINK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/TENM1/PFN2 20 BP GO:0046683 response to organophosphorus 20/1096 134/18670 0.0001072 0.001343 0.0009112 P2RY6/ADIPOQ/PCK1/PTK2B/STC1/IL1B/SDC1/ASS1/PTAFR/HSPA5/AQP9/COL1A1/CDO1/AKAP9/RAPGEF1/AQP1/IGFBP5/STAT1/CARM1/JUN 20 BP GO:0019751 polyol metabolic process 19/1096 124/18670 0.0001106 0.001384 0.0009385 PLCB1/MECP2/P2RY6/PCK1/PTK2B/AKR1B1/PLEK/SLC5A3/GCH1/GK/PTAFR/PLCG2/PCBD1/GOT1/MINPP1/QDPR/INPP5D/PCK2/NUDT3 19 BP GO:1901623 regulation of lymphocyte chemotaxis 8/1096 27/18670 0.0001119 0.001397 0.0009473 CCL5/CXCL13/PTK2B/CCR2/CXCL10/TNFSF14/CCL2/CCL7 8 BP GO:0035306 positive regulation of dephosphorylation 12/1096 58/18670 0.0001139 0.001419 0.0009624 MAGI2/LILRB2/PLEK/SMAD3/ADORA1/RGN/PTPRC/CDH5/PIN1/PINK1/DLC1/CAMTA1 12 BP GO:0045185 maintenance of protein location 17/1096 105/18670 0.0001257 0.001561 0.001059 NFKBIE/SRGN/DZIP1/ARL2/GSN/ANK3/FLNB/DAG1/HK2/TLN2/NFKBIA/HSPA5/GPAA1/PINK1/KDELR3/VPS13A/KDELR1 17 BP GO:0010927 cellular component assembly involved in morphogenesis 18/1096 115/18670 0.0001259 0.001561 0.001059 TMOD1/DAG1/TNNT1/MYL2/LDB3/MYH11/MYH10/CASQ2/CSRP1/MYOM2/CAV3/ACTA1/TTN/MYBPC2/TLR2/NEB/PDGFRA/MYOM1 18 BP GO:0071347 cellular response to interleukin-1 24/1096 179/18670 0.0001313 0.001619 0.001098 PLCB1/CCL5/CCL13/IL1RN/PCK1/ICAM1/IL1B/CCL18/MAPK3/CXCL8/NFKBIA/NFKB1/CHI3L1/MYD88/TFPI/HIF1A/GBP2/GBP1/MAPK13/SFRP1/CCL2/IKBKG/CCL7/HYAL1 24 BP GO:0001776 leukocyte homeostasis 15/1096 86/18670 0.0001317 0.001619 0.001098 TNFAIP3/SH2B2/CORO1A/AXL/ADA/GPR183/CCR2/CXCL6/HIF1A/NCKAP1L/TNFRSF17/TNFSF14/IL2RA/LAT/CCNB2 15 BP GO:0032760 positive regulation of tumor necrosis factor production 15/1096 86/18670 0.0001317 0.001619 0.001098 ZBTB20/LPL/RASGRP1/CD2/HSPB1/PTAFR/PTPRC/LY96/CD14/LILRA2/CCR2/PF4/TLR2/LBP/TWIST1 15 BP GO:0070542 response to fatty acid 15/1096 86/18670 0.0001317 0.001619 0.001098 TGFBR3/LPL/P2RY6/ADIPOQ/CCR7/ID3/ASS1/PTAFR/ADCY6/CDK4/CCNB1/BAD/TLR2/PTGER2/SFRP1 15 BP GO:0072010 glomerular epithelium development 7/1096 21/18670 0.0001323 0.001622 0.0011 MAGI2/ADIPOQ/BMP4/PECAM1/BASP1/LAMB2/FOXC1 7 BP GO:0006959 humoral immune response 39/1096 356/18670 0.0001329 0.001627 0.001103 TRBC1/FCN1/RARRES2/CXCL13/CCL13/CFB/SLPI/GATA3/SH2D1A/FCGR2B/IL1B/CCR7/PTPN6/GPR183/CXCL8/S100A9/PTPRC/CXCL1/CFP/CD83/CFD/CCR2/CXCL6/IGKC/CFI/PHB/CCR6/PF4/CXCL3/CXCL10/GNLY/IGLV6-57/C6/APCS/IGLC1/C7/C3AR1/CCL2/ELANE 39 BP GO:2000351 regulation of endothelial cell apoptotic process 12/1096 59/18670 0.0001355 0.001655 0.001122 TNFAIP3/ANGPT1/SEMA5A/ICAM1/GATA3/CD40/ITGA4/GAS6/GATA2/MAPK7/SERPINE1/CCL2 12 BP GO:0097327 response to antineoplastic agent 16/1096 96/18670 0.0001389 0.001692 0.001148 FOXO1/EGFR/ADIRF/PCK1/ICAM1/ATRX/DAXX/ASS1/PTAFR/MAP4K1/CDK4/AQP1/MAPK13/DDIT4/TFAP4/PCK2 16 BP GO:0051480 regulation of cytosolic calcium ion concentration 39/1096 357/18670 0.000141 0.001715 0.001163 PLCB1/CXCR4/CXCL13/CORO1A/P2RY6/ITGAV/LCK/PTK2B/CALB2/SMAD3/CCR7/S1PR1/ADORA1/PLN/PTPN6/TGM2/NOL3/CCR5/NMB/CD38/PTPRC/CASQ2/PLCG2/CX3CR1/GATA2/CCR2/CAV3/F2R/THY1/CXCR6/GOT1/CCR6/CXCL10/AGTR1/PTGER2/C3AR1/PDGFRA/S1PR4/CD52 39 BP GO:0002456 T cell mediated immunity 17/1096 106/18670 0.0001417 0.001719 0.001166 TNFRSF1B/IL7R/ICAM1/EMP2/CD8A/GATA3/FCGR2B/IL1B/RFTN1/RAB27A/CTSC/PTPRC/HPRT1/CTSH/CCR2/KDELR1/NLRP3 17 BP GO:0007254 JNK cascade 27/1096 214/18670 0.0001459 0.001766 0.001198 PLCB1/EGFR/PHLPP1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAP3K4/MFHAS1/CD27/SASH1/PTPN22/RAPGEF1/PINK1/MAP4K1/FZD7/MAPK10/ARHGEF5/SFRP1/DUSP3/IKBKG 27 BP GO:0060048 cardiac muscle contraction 20/1096 137/18670 0.0001462 0.001766 0.001198 CXCR4/BIN1/STC1/ADORA1/NEDD4L/PLN/TNNT1/MYL2/RGS2/KCNJ8/CASQ2/MYH7/TNNC1/CAV3/MYL3/ATP2A1/SNTA1/MYL1/TTN/HDAC4 20 BP GO:0045926 negative regulation of growth 30/1096 249/18670 0.0001485 0.001791 0.001215 SPP1/SERPINE2/CRYAB/SEMA5A/TGFB2/SEMA3E/SEMA3A/ENPP1/ADIPOR2/SMAD3/PAK1/RBP4/MYL2/RGS2/CDKN2C/MT1G/CAV3/SEMA3C/HIF1A/SEMA4F/BMP4/PHB/IGFBP5/JARID2/LGMN/SFRP1/FGFR3/FHL1/TSPYL2/HYAL1 30 BP GO:0010863 positive regulation of phospholipase C activity 10/1096 43/18670 0.0001511 0.001818 0.001233 P2RY6/EGFR/ITK/NTRK3/PTAFR/FGFR1/NTF3/PDGFRA/S1PR4/FLT1 10 BP GO:1901222 regulation of NIK/NF-kappaB signaling 18/1096 117/18670 0.0001576 0.001892 0.001284 LITAF/EGFR/TNFRSF10B/CPNE1/IL1B/NR3C2/NFKBIA/NOL3/CHI3L1/CD14/CD27/SASH1/PTPN22/TLR2/NLRP3/PTP4A3/TNFSF14/PPM1A 18 BP GO:0042113 B cell activation 35/1096 310/18670 0.0001609 0.001927 0.001307 TRBC1/TNFAIP3/IL7R/ADA/PRKCB/PTK2B/CD40/FCGR2B/TP53BP1/XBP1/PTPN6/GPR183/IL27RA/BATF/AKAP17A/CD38/KLF6/PTPRC/ITGA4/PLCG2/CD27/ERCC1/PARP3/TNFRSF4/IGKC/LFNG/CCR6/NCKAP1L/BAD/HDAC4/INPP5D/TFRC/IGLC1/SFRP1/PTPN2 35 BP GO:0046631 alpha-beta T cell activation 20/1096 138/18670 0.0001617 0.001933 0.001311 RUNX3/IL4R/ZBTB16/RELB/ITK/ADA/IRF1/GATA3/TCF7/GPR183/BATF/PTPRC/CD83/CCR2/ELF4/NCKAP1L/SATB1/CD86/NLRP3/IL15 20 BP GO:0014074 response to purine-containing compound 21/1096 149/18670 0.0001675 0.001994 0.001352 P2RY6/ADIPOQ/PCK1/PTK2B/STC1/IL1B/SDC1/ASS1/PTAFR/HSPA5/CASQ2/AQP9/COL1A1/CDO1/AKAP9/RAPGEF1/AQP1/IGFBP5/STAT1/CARM1/JUN 21 BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 21/1096 149/18670 0.0001675 0.001994 0.001352 ADAM8/ICAM1/PRKCB/AIM2/CD40/NFKB2/IL1B/S100A9/NFKB1/TRAF1/MID2/MYD88/CX3CR1/AR/ERC1/TLR2/PRKCH/NLRP3/CARM1/ITGB2/IKBKG 21 BP GO:0002819 regulation of adaptive immune response 22/1096 160/18670 0.0001705 0.002026 0.001374 TNFAIP3/TNFRSF1B/IL4R/IL7R/CD226/ADA/IRF1/GATA3/CD48/CD40/FCGR2B/IL1B/TP53BP1/PTPN6/IL27RA/PTPRC/SKAP1/CCR2/PARP3/IRF7/NLRP3/TFRC 22 BP GO:0043901 negative regulation of multi-organism process 23/1096 171/18670 0.0001713 0.002031 0.001377 FCN1/TNFAIP3/CCL5/GSN/ITGAV/HPGDS/ADA/SLPI/MID2/LILRA2/PLSCR1/ISG20/ARHGDIB/HDAC1/PCBP2/HTRA1/STAT1/APCS/TFAP4/IL2RA/PRDX2/VAPA/JUN 23 BP GO:1990089 response to nerve growth factor 11/1096 52/18670 0.0001771 0.002095 0.001421 MAGI2/CORO1A/NTRK3/EEF2/HSPA5/ID1/RAPGEF1/NTF3/NGF/STMN2/ARPC3 11 BP GO:0046364 monosaccharide biosynthetic process 16/1096 98/18670 0.000178 0.002102 0.001426 FOXO1/ADIPOQ/PCK1/AKR1B1/RBP4/SIK1/RGN/GOT2/PDK2/PC/GOT1/PGD/PTPN2/SDS/ALDOA/PCK2 16 BP GO:2000146 negative regulation of cell motility 38/1096 349/18670 0.0001827 0.002153 0.00146 PLCB1/MAGI2/CXCL13/MECP2/CD200/ADIPOQ/SEMA3A/ADA/GATA3/STC1/DAG1/SULF1/ADORA3/ADORA1/IL27RA/RGN/CX3CR1/ARHGDIB/DLG5/KANK1/PIN1/THY1/LDLRAD4/DLC1/IGFBP5/PRKG1/APOE/SERPINE1/BMPR1A/CXCL12/ABR/SFRP1/DUSP3/ANGPT2/CCL2/SPINT2/PFN2/COL3A1 38 BP GO:0044242 cellular lipid catabolic process 27/1096 217/18670 0.000184 0.002164 0.001467 LPL/FABP4/ECH1/ADIPOQ/PCK1/CRAT/ECI1/PNPLA6/ECHS1/LIPC/ACADS/HADH/PLCG2/SLC27A2/PNPLA4/APOC1/INPP5F/ACOX2/AKR1B10/APOE/TWIST1/AOAH/ALDH3A2/PLA2G15/NAGA/PCK2/ETFB 27 BP GO:0030225 macrophage differentiation 10/1096 44/18670 0.0001854 0.002171 0.001472 VEGFA/ADIPOQ/HCLS1/GATA2/TSPAN2/BMP4/PF4/TLR2/PTPN2/IL15 10 BP GO:0071622 regulation of granulocyte chemotaxis 10/1096 44/18670 0.0001854 0.002171 0.001472 CCL5/RAC2/RARRES2/CCR7/MAPK3/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 10 BP GO:0034121 regulation of toll-like receptor signaling pathway 13/1096 70/18670 0.0001903 0.002224 0.001508 TNFAIP3/IRF1/BIRC3/LY96/MFHAS1/CD14/LILRA2/PTPN22/GRAMD4/TLR2/IRF7/LBP/TYRO3 13 BP GO:0014866 skeletal myofibril assembly 6/1096 16/18670 0.0001941 0.002256 0.00153 MYH11/MYOM2/ACTA1/TTN/MYBPC2/MYOM1 6 BP GO:0033631 cell-cell adhesion mediated by integrin 6/1096 16/18670 0.0001941 0.002256 0.00153 CCL5/CXCL13/ADA/ITGA4/SKAP1/ITGA5 6 BP GO:0038093 Fc receptor signaling pathway 29/1096 241/18670 0.0001942 0.002256 0.00153 CD247/ITK/MS4A2/FCGR2B/PAK1/MAPK3/DOCK1/GAB2/NFKB1/PTPRC/MYH2/LCP2/PLCG2/PAK2/CD3G/RAPGEF1/FCGR2A/IGKC/NCKAP1/NCKAP1L/MAPK10/IGLV6-57/ARPC3/VAV1/IGLC1/IKBKG/CYFIP2/JUN/LAT 29 BP GO:1902624 positive regulation of neutrophil migration 8/1096 29/18670 0.0001948 0.002258 0.001531 ADAM8/RAC2/CCR7/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 8 BP GO:0001952 regulation of cell-matrix adhesion 18/1096 119/18670 0.0001962 0.002269 0.001539 DDR2/VEGFA/EPHA3/SEMA3E/EMP2/PTK2B/DAG1/POSTN/SMAD3/CCR7/SKAP1/THY1/DLC1/EFNA5/NINJ1/SERPINE1/SFRP1/DUSP3 18 BP GO:0014897 striated muscle hypertrophy 17/1096 109/18670 0.0002007 0.002317 0.001572 FOXO1/TNFRSF1B/SORBS2/SMAD3/PAK1/RGS2/MYH7/INPP5F/CAV3/PIN1/TTN/IGFBP5/PDE9A/HDAC4/CAMTA2/PDLIM5/JARID2 17 BP GO:0016999 antibiotic metabolic process 21/1096 151/18670 0.0002023 0.002331 0.001581 RAC2/HBB/EGFR/ADH1B/PXDN/PCK1/GPX3/AKR1B1/ADH1A/ADH1C/ALDH5A1/ALDH3B1/PINK1/AKR7A2/GPX1/ZNF205/AKR1B10/LPO/PRDX2/PCK2/HBE1 21 BP GO:0003018 vascular process in circulatory system 23/1096 173/18670 0.0002039 0.002344 0.00159 ANGPT1/HBB/VEGFA/EGFR/ICAM1/ADORA1/GCH1/PTAFR/CD38/RGS2/CDH5/ADCY6/ACTA2/F2R/GPX1/PRKG1/APOE/CTNNBIP1/ABR/AGTR1/PTP4A3/FOXC1/CHRM3 23 BP GO:0043010 camera-type eye development 35/1096 314/18670 0.0002064 0.002364 0.001603 TMOD1/CRYAB/TGFB2/VEGFA/CDON/EGFR/GATA3/NTRK3/SMAD3/RBP4/MYH10/MYOM2/SMARCD3/HIF1A/THY1/BMP4/CDK4/B9D1/DIO3/HDAC1/LRP5/EFEMP1/JMJD6/NINJ1/TWIST1/LAMB2/FOXC1/OSR2/PDGFRA/IMPDH2/RING1/MYOM1/RXRA/COL4A1/JUN 35 BP GO:0070555 response to interleukin-1 26/1096 207/18670 0.0002064 0.002364 0.001603 PLCB1/CCL5/CCL13/IL1RN/PCK1/ICAM1/IL1B/CCL18/MAPK3/CXCL8/NFKBIA/NFKB1/CD38/CHI3L1/MYD88/TFPI/HIF1A/GBP2/GBP1/HDAC4/MAPK13/SFRP1/CCL2/IKBKG/CCL7/HYAL1 26 BP GO:0003231 cardiac ventricle development 19/1096 130/18670 0.0002088 0.002387 0.001619 TGFBR3/TGFB2/GATA3/FZD2/MYL2/MYH7/TNNC1/SEMA3C/MYL3/SMARCD3/HIF1A/BMP4/TNNI1/UBE4B/BMPR1A/FOXC1/NPRL3/SMAD6/RXRA 19 BP GO:0003015 heart process 33/1096 290/18670 0.0002114 0.00241 0.001635 CXCR4/WWTR1/TGFB2/SEMA3A/ADA/HBEGF/THRA/BIN1/STC1/FXYD1/DES/ADORA3/ADORA1/NEDD4L/PLN/GCH1/TNNT1/MYL2/RGS2/KCNJ8/CASQ2/ASPH/MYH7/TNNC1/CAV3/MYL3/AKAP9/GPX1/ATP2A1/SNTA1/MYL1/TTN/HDAC4 33 BP GO:0071320 cellular response to cAMP 11/1096 53/18670 0.0002118 0.00241 0.001635 ADIPOQ/PCK1/STC1/ASS1/PTAFR/HSPA5/AQP9/AKAP9/RAPGEF1/AQP1/IGFBP5 11 BP GO:0007431 salivary gland development 9/1096 37/18670 0.0002237 0.002541 0.001723 TGFB2/EGFR/SEMA3A/NFIB/DAG1/XBP1/TGM2/FGFR1/SEMA3C 9 BP GO:1900274 regulation of phospholipase C activity 10/1096 45/18670 0.0002259 0.002561 0.001737 P2RY6/EGFR/ITK/NTRK3/PTAFR/FGFR1/NTF3/PDGFRA/S1PR4/FLT1 10 BP GO:0002221 pattern recognition receptor signaling pathway 25/1096 197/18670 0.0002309 0.002608 0.001769 FCN1/TNFAIP3/IRF1/BIRC3/RFTN1/TRIL/NFKBIA/S100A9/LY96/MFHAS1/CD14/CTSL/LILRA2/MYD88/PTPN22/GRAMD4/TLR2/IRF7/LBP/TRAF3/LGMN/ITGB2/IKBKG/IKBKE/TYRO3 25 BP GO:0010952 positive regulation of peptidase activity 25/1096 197/18670 0.0002309 0.002608 0.001769 GSN/TNFRSF10B/LCK/AIM2/SMAD3/CTSD/MAPK3/DAP/S100A9/TNFSF10/ASPH/CTSH/CASP4/F2R/PINK1/DLC1/HIP1/BAD/GRAMD4/NGF/NLRP3/TFAP4/LGMN/CYFIP2/PCOLCE 25 BP GO:0030241 skeletal muscle myosin thick filament assembly 5/1096 11/18670 0.0002369 0.002659 0.001804 MYH11/MYOM2/TTN/MYBPC2/MYOM1 5 BP GO:0033089 positive regulation of T cell differentiation in thymus 5/1096 11/18670 0.0002369 0.002659 0.001804 ADAM8/IL7R/RASGRP1/ADA/EGR3 5 BP GO:0071688 striated muscle myosin thick filament assembly 5/1096 11/18670 0.0002369 0.002659 0.001804 MYH11/MYOM2/TTN/MYBPC2/MYOM1 5 BP GO:0072006 nephron development 20/1096 142/18670 0.0002393 0.002681 0.001818 MAGI2/ANGPT1/WWTR1/VEGFA/ADIPOQ/SIX1/GATA3/SULF1/MAGED1/ACTA2/BMP4/PECAM1/BASP1/STAT1/CTNNBIP1/LAMB2/FOXC1/ANGPT2/PDGFRA/HOXA11 20 BP GO:0060047 heart contraction 32/1096 280/18670 0.0002421 0.002704 0.001834 CXCR4/TGFB2/SEMA3A/ADA/HBEGF/THRA/BIN1/STC1/FXYD1/DES/ADORA3/ADORA1/NEDD4L/PLN/GCH1/TNNT1/MYL2/RGS2/KCNJ8/CASQ2/ASPH/MYH7/TNNC1/CAV3/MYL3/AKAP9/GPX1/ATP2A1/SNTA1/MYL1/TTN/HDAC4 32 BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 30/1096 256/18670 0.0002423 0.002704 0.001834 CCL5/ANGPT1/TGFA/VEGFA/EGFR/ADIPOQ/ICAM1/HBEGF/PTK2B/CD40/ADORA1/PTPN6/CD44/PTPRC/PAK2/HCLS1/GAS6/INPP5F/THY1/ITGA5/EFNA5/PECAM1/NTF3/THBS4/SFRP1/ITGB2/PTPN2/FGFR3/CRLF1/IL15 30 BP GO:0014896 muscle hypertrophy 17/1096 111/18670 0.0002511 0.002779 0.001885 FOXO1/TNFRSF1B/SORBS2/SMAD3/PAK1/RGS2/MYH7/INPP5F/CAV3/PIN1/TTN/IGFBP5/PDE9A/HDAC4/CAMTA2/PDLIM5/JARID2 17 BP GO:0032703 negative regulation of interleukin-2 production 7/1096 23/18670 0.0002515 0.002779 0.001885 TNFAIP3/GATA3/PTPRC/HOMER3/LAG3/GBP1/KAT5 7 BP GO:0048714 positive regulation of oligodendrocyte differentiation 7/1096 23/18670 0.0002515 0.002779 0.001885 TNFRSF1B/CXCR4/ZNF365/DAG1/ASPA/HDAC1/TLR2 7 BP GO:0051043 regulation of membrane protein ectodomain proteolysis 7/1096 23/18670 0.0002515 0.002779 0.001885 TNFRSF1B/ADAM8/TIMP4/IL1B/TIMP2/TIMP3/APOE 7 BP GO:0060055 angiogenesis involved in wound healing 7/1096 23/18670 0.0002515 0.002779 0.001885 TNFAIP3/CXCR4/DAG1/ADIPOR2/XBP1/GPX1/SERPINE1 7 BP GO:0046632 alpha-beta T cell differentiation 16/1096 101/18670 0.0002547 0.002806 0.001903 RUNX3/IL4R/ZBTB16/RELB/ITK/ADA/IRF1/GATA3/TCF7/GPR183/BATF/CD83/NCKAP1L/SATB1/CD86/NLRP3 16 BP GO:0060193 positive regulation of lipase activity 13/1096 72/18670 0.0002549 0.002806 0.001903 CCL5/P2RY6/EGFR/ITK/NTRK3/PTAFR/FGFR1/NTF3/AGTR1/FGFR3/PDGFRA/S1PR4/FLT1 13 BP GO:1903409 reactive oxygen species biosynthetic process 18/1096 122/18670 0.0002694 0.00296 0.002008 HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/RAB27A/INSR/TRAP1/CX3CR1/NQO1/ZNF205/HDAC4/ITGB2/SLC18A2 18 BP GO:0030279 negative regulation of ossification 14/1096 82/18670 0.0002754 0.003014 0.002044 SRGN/ENPP1/PTK2B/SMAD3/ID3/ID1/HIF1A/LRP5/IGFBP5/GDF10/HDAC4/TWIST1/SFRP1/SMAD6 14 BP GO:0046209 nitric oxide metabolic process 14/1096 82/18670 0.0002754 0.003014 0.002044 HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/INSR/CX3CR1/NQO1/TLR2/ITGB2 14 BP GO:0007204 positive regulation of cytosolic calcium ion concentration 35/1096 319/18670 0.0002792 0.00305 0.002069 PLCB1/CXCR4/CXCL13/CORO1A/P2RY6/ITGAV/LCK/PTK2B/CCR7/S1PR1/PLN/PTPN6/TGM2/NOL3/CCR5/NMB/CD38/PTPRC/CASQ2/PLCG2/CX3CR1/GATA2/CCR2/CAV3/F2R/THY1/CXCR6/CCR6/CXCL10/AGTR1/PTGER2/C3AR1/PDGFRA/S1PR4/CD52 35 BP GO:0048871 multicellular organismal homeostasis 48/1096 485/18670 0.0002804 0.003057 0.002073 NOVA1/SPP1/FOXO1/TNFAIP3/IL4R/CXCR4/FTO/ADAM8/RAC2/CORO1A/WWTR1/FABP4/VEGFA/EGFR/ADIPOQ/THRA/AKT3/UGCG/PTK2B/IL1B/AKR1B1/ADIPOR2/S1PR1/ADCY9/RBP4/ADORA1/HSPB1/CD38/AMPD3/HADH/ID1/UCP2/ADCY6/GATA2/CTSH/CCR2/F2R/G0S2/GPX1/IGKC/AQP1/CSK/INPP5D/FOXC1/TFRC/WFS1/IL15/ADCY1 48 BP GO:0002705 positive regulation of leukocyte mediated immunity 19/1096 133/18670 0.0002819 0.003067 0.00208 IL4R/STXBP1/RASGRP1/CD226/GATA3/SH2D1A/CD40/IL1B/TP53BP1/GAB2/PTAFR/PTPRC/CRTAM/GATA2/LAG3/NLRP3/VAV1/TFRC/ITGB2 19 BP GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 6/1096 17/18670 0.0002851 0.003096 0.0021 ICAM1/PTAFR/ITGA4/CCR2/ITGB2/ELANE 6 BP GO:0003229 ventricular cardiac muscle tissue development 11/1096 55/18670 0.0002985 0.003236 0.002195 TGFBR3/TGFB2/MYL2/MYH7/TNNC1/MYL3/TNNI1/UBE4B/BMPR1A/FOXC1/RXRA 11 BP GO:0006470 protein dephosphorylation 35/1096 321/18670 0.0003143 0.003401 0.002307 MAGI2/PHLPP1/LILRB2/LCK/DUSP5/PPP1R3C/PTPN13/PTPN7/PTPN21/ADORA1/CDC25B/PTPN6/RGN/PTPRC/CDH5/MFHAS1/DUSP14/PTPN22/MGAT5/PIN1/PINK1/DLC1/PPP1R2/MINPP1/NCKAP1L/PPP1R1A/DUSP2/PTPRF/PTP4A3/DUSP3/PPM1A/PTPN2/CAMTA1/PPP3CC/PTPRE 35 BP GO:0032868 response to insulin 31/1096 272/18670 0.0003155 0.003407 0.002311 FOXO1/LPL/RARRES2/EGR2/SH2B2/ADIPOQ/PCK1/ICAM1/ENPP1/PRKCB/IL1B/PAK1/XBP1/PLN/GOT2/TNFSF10/PDK2/HADH/INSR/KANK1/GOT1/CDK4/TLR2/TBC1D4/HSD11B2/STAT1/PTPN2/INHBB/ATP6V0D1/PTPRE/PCK2 31 BP GO:0033273 response to vitamin 15/1096 93/18670 0.0003217 0.003462 0.002348 SPP1/GSN/EGFR/ADA/STC1/EEF2/POSTN/CCND1/ALPL/COL1A1/GAS6/PIM1/CXCL10/SFRP1/IL15 15 BP GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 8/1096 31/18670 0.0003224 0.003462 0.002348 TGFB2/SMAD3/SMAD1/GATA2/HIF1A/BMPR1A/SMAD6/JUN 8 BP GO:2000406 positive regulation of T cell migration 8/1096 31/18670 0.0003224 0.003462 0.002348 CCL5/ADAM8/CXCL13/ITGA4/CCR2/CXCL10/CXCL12/TNFSF14 8 BP GO:0032386 regulation of intracellular transport 43/1096 423/18670 0.0003251 0.003485 0.002364 IL4R/RAC2/HUWE1/ANGPT1/CRYAB/STXBP1/ADIPOQ/ANK3/LCP1/PRKCB/TCF7L2/IL1B/SMAD3/ZIC1/PAK1/MAPK3/PLN/GAB2/ARHGAP1/RAB29/TM9SF4/PKIG/HCLS1/GAS6/GATA2/STXBP2/INPP5F/TNNC1/PINK1/BMP4/GAS1/UNC13B/ATP2A1/MX2/UBE2J1/RIMS3/SPAG5/ITGB2/PPM1A/TENM1/PFN2/TRIM58/ADCY1 43 BP GO:0001649 osteoblast differentiation 27/1096 225/18670 0.0003323 0.003554 0.002411 SPP1/DDR2/WWTR1/ZHX3/SMAD3/TPM4/NELL1/ID3/ALPL/PTHLH/SMAD1/ID1/COL1A1/ID4/BMP4/LRP5/PHB/IGFBP5/SND1/FBL/CTNNBIP1/GDF10/HDAC4/BMPR1A/TWIST1/SFRP1/SMAD6 27 BP GO:0031579 membrane raft organization 7/1096 24/18670 0.0003371 0.003557 0.002413 GSN/EMP2/RFTN1/CD2/PTPRC/NPC1/CAV3 7 BP GO:0033081 regulation of T cell differentiation in thymus 7/1096 24/18670 0.0003371 0.003557 0.002413 ADAM8/IL7R/RASGRP1/ADA/EGR3/BMP4/PTPN2 7 BP GO:0071677 positive regulation of mononuclear cell migration 7/1096 24/18670 0.0003371 0.003557 0.002413 CCL5/CCR2/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN 7 BP GO:0090023 positive regulation of neutrophil chemotaxis 7/1096 24/18670 0.0003371 0.003557 0.002413 RAC2/CCR7/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 7 BP GO:0008361 regulation of cell size 23/1096 179/18670 0.0003371 0.003557 0.002413 SPP1/IL7R/SEMA5A/VEGFA/SEMA3E/SEMA3A/AKT3/NTRK3/PLEK/PAK1/OLFM1/CAV3/SEMA3C/SEMA4F/EFNA5/CDK4/AQP1/APOE/NGF/CTTN/CXCL12/VAV1/DPYSL2 23 BP GO:1903034 regulation of response to wounding 23/1096 179/18670 0.0003371 0.003557 0.002413 SPP1/TNFAIP3/SERPINE2/CXCR4/HBEGF/NTRK3/PLEK/SMAD3/XBP1/PDPN/TFPI/INPP5F/KANK1/F2R/PLAUR/PRKG1/APOE/SERPINE1/PTPRF/APCS/PDGFRA/PRDX2/SELP 23 BP GO:0032507 maintenance of protein location in cell 13/1096 74/18670 0.0003375 0.003557 0.002413 ARL2/GSN/ANK3/FLNB/DAG1/HK2/TLN2/HSPA5/GPAA1/PINK1/KDELR3/VPS13A/KDELR1 13 BP GO:0032677 regulation of interleukin-8 production 13/1096 74/18670 0.0003375 0.003557 0.002413 FCN1/ADIPOQ/IL1B/CD2/PTPRC/CD14/MYD88/PTPN22/F2R/TLR2/SERPINE1/LBP/ELANE 13 BP GO:0110053 regulation of actin filament organization 30/1096 261/18670 0.0003384 0.00356 0.002415 TMOD1/CORO1A/SEMA5A/GSN/ICAM1/BIN1/ARHGEF10/PTK2B/PLEK/SMAD3/CCR7/PAK1/S1PR1/SPTBN1/ID1/HCLS1/CAPG/KANK1/DLC1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/CXCL12/ARHGEF5/SFRP1/TENM1/PFN2 30 BP GO:0038179 neurotrophin signaling pathway 9/1096 39/18670 0.0003427 0.003598 0.002441 MAGI2/CORO1A/NTRK3/RAPGEF1/NTF3/NGF/DDIT4/SPRY1/CYFIP2 9 BP GO:0034614 cellular response to reactive oxygen species 22/1096 168/18670 0.0003444 0.003609 0.002448 FOXO1/TNFAIP3/EGFR/AXL/PCGF2/MAPK3/GCH1/RGN/FBLN5/PDK2/TRAP1/PINK1/CCNA2/NQO1/MAPK7/AQP1/FANCC/MAPK13/PDGFRA/BNIP3/PRDX2/JUN 22 BP GO:0002548 monocyte chemotaxis 12/1096 65/18670 0.0003523 0.003679 0.002495 CCL5/CCL13/CCL18/CCR2/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN/CCL2/CCL7/FLT1 12 BP GO:0072577 endothelial cell apoptotic process 12/1096 65/18670 0.0003523 0.003679 0.002495 TNFAIP3/ANGPT1/SEMA5A/ICAM1/GATA3/CD40/ITGA4/GAS6/GATA2/MAPK7/SERPINE1/CCL2 12 BP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 16/1096 104/18670 0.0003584 0.003735 0.002534 TNFAIP3/ITGAV/TNFRSF10B/ICAM1/TCF7L2/IL1B/NOL3/TNFSF10/AR/BMP4/GPX1/MAPK7/PF4/SERPINE1/CTTN/PRDX2 16 BP GO:0071383 cellular response to steroid hormone stimulus 29/1096 250/18670 0.0003621 0.003767 0.002555 FOXO1/EGFR/PCK1/ICAM1/THRA/PGRMC2/STC1/PAK1/DAXX/NR3C2/ASS1/CNOT1/NPC1/TRIP4/AR/TFPI/BMP4/HDAC1/PHB/AQP1/TADA3/LMO3/KAT5/DDIT4/CARM1/TFAP4/SFRP1/RXRA/PCK2 29 BP GO:0030832 regulation of actin filament length 23/1096 180/18670 0.0003655 0.003789 0.00257 TMOD1/CORO1A/SEMA5A/GSN/ICAM1/BIN1/PTK2B/PLEK/CCR7/SPTBN1/HCLS1/CAPG/KANK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/NEB/CTTN/ARPC3/CXCL12/TENM1/PFN2 23 BP GO:0071346 cellular response to interferon-gamma 23/1096 180/18670 0.0003655 0.003789 0.00257 CCL5/CCL13/STXBP1/GSN/ICAM1/FLNB/IRF1/CCL18/ASS1/PTAFR/CD44/STXBP2/NMI/IRF8/GBP2/TLR2/STAT1/GBP1/IRF7/PTPN2/CCL2/OAS2/CCL7 23 BP GO:0060538 skeletal muscle organ development 22/1096 169/18670 0.0003744 0.003874 0.002628 EGR2/CDON/MYL6B/HLF/SIX1/SVIL/FLNB/NUPR1/EEF2/BTG2/PITX1/ASS1/SRPK3/KCNAB1/MYOM2/ACTA1/GPX1/BASP1/HDAC4/TWIST1/MAFF/MYOM1 22 BP GO:0019932 second-messenger-mediated signaling 44/1096 439/18670 0.0003781 0.003905 0.002648 CXCR4/P2RY6/VEGFA/EGFR/NCALD/ADA/PTK2B/PLEK/CCR7/ADCY9/PLN/RGN/CXCL8/CCR5/RGS2/PTPRC/CASQ2/PDK2/PTHLH/PLCG2/CX3CR1/ADCY6/CCR2/DYRK2/CXCR6/HOMER3/MAPK7/AQP1/CCR6/PF4/PRKG1/GBP1/APOE/CXCL10/PDE9A/HDAC4/AGTR1/PTGER2/CAMTA1/S1PR4/PPP3CC/SELP/ADCY1/LAT 44 BP GO:0031348 negative regulation of defense response 28/1096 239/18670 0.0003862 0.00393 0.002666 TNFAIP3/TNFRSF1B/TNFAIP6/CD200/ADIPOQ/ADA/GATA3/FCGR2B/SMAD3/ADORA1/NFKB1/PTPRC/CDH5/MFHAS1/CST7/NMI/GPX1/MAPK7/PCBP2/HTRA1/APOE/ABR/NLRP3/APCS/PTPN2/IL2RA/TYRO3/ELANE 28 BP GO:0031034 myosin filament assembly 5/1096 12/18670 0.0003865 0.00393 0.002666 MYH11/MYOM2/TTN/MYBPC2/MYOM1 5 BP GO:0038110 interleukin-2-mediated signaling pathway 5/1096 12/18670 0.0003865 0.00393 0.002666 IL2RG/IL2RB/PTK2B/PTPN2/IL2RA 5 BP GO:0038180 nerve growth factor signaling pathway 5/1096 12/18670 0.0003865 0.00393 0.002666 MAGI2/CORO1A/RAPGEF1/NTF3/NGF 5 BP GO:0045579 positive regulation of B cell differentiation 5/1096 12/18670 0.0003865 0.00393 0.002666 XBP1/CD27/NCKAP1L/BAD/INPP5D 5 BP GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 5/1096 12/18670 0.0003865 0.00393 0.002666 CD226/PTPRC/PLSCR1/RAPGEF1/CSK 5 BP GO:0070486 leukocyte aggregation 5/1096 12/18670 0.0003865 0.00393 0.002666 RAC2/IL1B/S100A9/CD44/STK10 5 BP GO:0046173 polyol biosynthetic process 13/1096 75/18670 0.0003867 0.00393 0.002666 PLCB1/P2RY6/PCK1/PTK2B/AKR1B1/PLEK/GCH1/PTAFR/PLCG2/PCBD1/GOT1/QDPR/PCK2 13 BP GO:0150076 neuroinflammatory response 13/1096 75/18670 0.0003867 0.00393 0.002666 TNFRSF1B/CD200/EGFR/NUPR1/IL1B/NAMPT/CTSC/PTPRC/CST7/TLR2/ITGB2/JUN/ADCY1 13 BP GO:0002762 negative regulation of myeloid leukocyte differentiation 10/1096 48/18670 0.0003947 0.00399 0.002706 ADIPOQ/TCTA/LILRB4/GATA2/LILRB3/APCS/INPP5D/SFRP1/PTPN2/CUL4A 10 BP GO:0046850 regulation of bone remodeling 10/1096 48/18670 0.0003947 0.00399 0.002706 SPP1/TNFAIP3/ADAM8/EGFR/S1PR1/CD38/CSK/INPP5D/TFRC/SFRP1 10 BP GO:0072604 interleukin-6 secretion 10/1096 48/18670 0.0003947 0.00399 0.002706 LPL/CD200/IL1B/XBP1/IL27RA/LILRA2/GAS6/PTPN22/F2R/TWIST1 10 BP GO:0048864 stem cell development 14/1096 85/18670 0.000404 0.004069 0.00276 SEMA5A/SEMA3E/SEMA3A/FAM172A/MAPK3/PTPRC/SEMA3C/HIF1A/SEMA4F/BMP4/BMPR1A/TWIST1/FOXC1/NRP2 14 BP GO:2001057 reactive nitrogen species metabolic process 14/1096 85/18670 0.000404 0.004069 0.00276 HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/INSR/CX3CR1/NQO1/TLR2/ITGB2 14 BP GO:0070233 negative regulation of T cell apoptotic process 6/1096 18/18670 0.0004065 0.004087 0.002772 CCL5/IL7R/ADA/CD27/HIF1A/BMP4 6 BP GO:0042743 hydrogen peroxide metabolic process 11/1096 57/18670 0.0004134 0.004142 0.00281 RAC2/HBB/EGFR/PXDN/GPX3/PINK1/GPX1/ZNF205/LPO/PRDX2/HBE1 11 BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 11/1096 57/18670 0.0004134 0.004142 0.00281 HBB/ICAM1/PTK2B/IL1B/SMAD3/ASS1/RAB27A/INSR/ZNF205/HDAC4/ITGB2 11 BP GO:0051668 localization within membrane 20/1096 148/18670 0.0004165 0.004166 0.002825 MAGI2/ITGB7/GSN/CLSTN1/DAG1/RFTN1/CD2/ITGAL/RALA/PTPRC/ITGA4/DNM1/THY1/HIP1/MAPK10/USP46/APOE/GLRB/CDH2/ITGB2 20 BP GO:0042036 negative regulation of cytokine biosynthetic process 9/1096 40/18670 0.0004194 0.00418 0.002835 NFKB1/PTPRC/TRIB2/NMI/LAG3/INPP5D/ASB1/ELANE/INHBB 9 BP GO:0045124 regulation of bone resorption 9/1096 40/18670 0.0004194 0.00418 0.002835 SPP1/TNFAIP3/ADAM8/EGFR/S1PR1/CD38/CSK/INPP5D/TFRC 9 BP GO:2000027 regulation of animal organ morphogenesis 29/1096 253/18670 0.0004414 0.004389 0.002977 TNFAIP3/MAGI2/TGFB2/VEGFA/SIX1/NFIB/GATA3/SULF1/XBP1/FZD2/MAGED1/AR/FGFR1/CAV3/SEMA3C/BMP4/PIM1/FZD7/DIO3/BASP1/STAT1/BMPR1A/TWIST1/FOXC1/CARM1/SFRP1/HOXA11/SPRY1/RXRA 29 BP GO:0030500 regulation of bone mineralization 13/1096 76/18670 0.0004419 0.004389 0.002977 DDR2/SRGN/ENPP1/PTK2B/SMAD3/S1PR1/MGP/NELL1/HIF1A/BMP4/BMPR1A/TWIST1/OSR2 13 BP GO:0002335 mature B cell differentiation 7/1096 25/18670 0.0004447 0.004394 0.00298 ADA/PTK2B/FCGR2B/XBP1/GPR183/PLCG2/LFNG 7 BP GO:0050927 positive regulation of positive chemotaxis 7/1096 25/18670 0.0004447 0.004394 0.00298 VEGFA/NTRK3/SMAD3/S1PR1/CXCL8/NTF3/CXCL12 7 BP GO:0090025 regulation of monocyte chemotaxis 7/1096 25/18670 0.0004447 0.004394 0.00298 CCL5/CCR2/PLA2G7/SERPINE1/CXCL10/CXCL12/LGMN 7 BP GO:0003300 cardiac muscle hypertrophy 16/1096 106/18670 0.0004462 0.004401 0.002985 FOXO1/TNFRSF1B/SORBS2/SMAD3/PAK1/RGS2/MYH7/INPP5F/CAV3/PIN1/TTN/PDE9A/HDAC4/CAMTA2/PDLIM5/JARID2 16 BP GO:0002706 regulation of lymphocyte mediated immunity 20/1096 149/18670 0.0004551 0.004481 0.003039 TNFRSF1B/IL7R/RASGRP1/CD226/GATA3/SH2D1A/CD40/FCGR2B/IL1B/TP53BP1/PTPN6/IL27RA/PTPRC/CRTAM/CCR2/PARP3/LAG3/NLRP3/VAV1/TFRC 20 BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 14/1096 86/18670 0.0004569 0.004491 0.003046 TNFRSF10B/LCK/SMAD3/DAP/S100A9/TNFSF10/CTSH/CASP4/F2R/DLC1/HIP1/BAD/NGF/NLRP3 14 BP GO:0050770 regulation of axonogenesis 23/1096 183/18670 0.0004638 0.00455 0.003086 SPP1/UST/SIPA1L1/SEMA5A/VEGFA/SEMA3E/SEMA3A/CHN1/NTRK3/PAK1/OLFM1/SEMA3C/THY1/SEMA4F/EFNA5/APOE/NGF/PLXNC1/CTTN/PLXNA2/CXCL12/CDH2/DPYSL2 23 BP GO:0010632 regulation of epithelial cell migration 32/1096 291/18670 0.0004805 0.004706 0.003192 CXCL13/MECP2/ANGPT1/SEMA5A/TGFB2/VEGFA/MAPRE2/SEMA3A/EMP2/HBEGF/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/DOCK1/FGFR1/SASH1/PLK2/GATA2/CTSH/HIF1A/BMP4/CCR6/APOE/LGMN/NRP2/ANGPT2/PFN2/HYAL1/JUN 32 BP GO:0017001 antibiotic catabolic process 11/1096 58/18670 0.0004835 0.004728 0.003207 HBB/PXDN/PCK1/GPX3/ALDH3B1/GPX1/AKR1B10/LPO/PRDX2/PCK2/HBE1 11 BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 19/1096 139/18670 0.0004971 0.004835 0.00328 CD247/FCGR2B/PAK1/MAPK3/DOCK1/PTPRC/MYH2/PLCG2/CD3G/RAPGEF1/FCGR2A/IGKC/NCKAP1/NCKAP1L/IGLV6-57/ARPC3/VAV1/IGLC1/CYFIP2 19 BP GO:0002831 regulation of response to biotic stimulus 19/1096 139/18670 0.0004971 0.004835 0.00328 TNFAIP3/CD226/AIM2/BIRC3/IL1B/MAPK3/LY96/CRTAM/LILRA2/SASH1/CXCL6/UNC13B/PCBP2/HTRA1/STAT1/TRAF3/IL2RA/PRDX2/IL15 19 BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 19/1096 139/18670 0.0004971 0.004835 0.00328 CD247/FCGR2B/PAK1/MAPK3/DOCK1/PTPRC/MYH2/PLCG2/CD3G/RAPGEF1/FCGR2A/IGKC/NCKAP1/NCKAP1L/IGLV6-57/ARPC3/VAV1/IGLC1/CYFIP2 19 BP GO:0006809 nitric oxide biosynthetic process 13/1096 77/18670 0.0005035 0.004882 0.003311 HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/INSR/CX3CR1/NQO1/ITGB2 13 BP GO:0032481 positive regulation of type I interferon production 13/1096 77/18670 0.0005035 0.004882 0.003311 ZBTB20/IRF1/NFKB2/NFKB1/CD14/MYD88/PLCG2/PTPN22/POLR2E/TLR2/STAT1/IRF7/POLR1C 13 BP GO:0050873 brown fat cell differentiation 9/1096 41/18670 0.0005097 0.004928 0.003343 ALDH6A1/FTO/SH2B2/FABP4/ADIPOQ/RGS2/ARL4A/MB/BNIP3 9 BP GO:0090287 regulation of cellular response to growth factor stimulus 32/1096 292/18670 0.0005101 0.004928 0.003343 TGFBR3/CXCL13/VEGFA/GATA3/NTRK3/PRKCB/IL1B/SMAD3/SULF1/SFRP4/HSPA5/CDH5/ADAMTS3/FGFR1/CAV3/PIN1/HIF1A/LTBP4/LDLRAD4/GOT1/BMP4/ITGA5/NTF3/HTRA1/PTP4A3/SFRP1/PPM1A/SPRY1/SMAD6/CYFIP2/ADAMTSL2/FLT1 32 BP GO:0042176 regulation of protein catabolic process 39/1096 381/18670 0.0005275 0.005089 0.003451 FOXO1/TNFAIP3/TNFRSF1B/SERPINE2/ADAM8/EGFR/TIMP4/PTK2B/NUPR1/IL1B/SMAD3/NEDD4L/NELL1/RGN/RNF144A/CTSC/TRIB2/TIMP2/PLK2/CAV3/PIN1/PINK1/LAMP3/GPX1/EEF1A2/NFE2L1/PHB/TIMP3/CAMLG/UBE2J1/USP7/AREL1/APOE/RAD23B/PLK1/USP5/HERPUD1/PTTG1IP/GLMN 39 BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 18/1096 129/18670 0.0005385 0.005186 0.003517 RUNX3/IL4R/LILRB2/IRF1/FCGR2B/PTPN6/ASS1/DLG5/PTPN22/BMP4/LAG3/CD86/CXCL12/DUSP3/PTPN2/IL2RA/PRDX2/GLMN 18 BP GO:0007369 gastrulation 23/1096 185/18670 0.0005414 0.005204 0.00353 ITGAV/ADIPOQ/IL1RN/DAG1/SMAD3/ITGA4/SMAD1/FGFR1/PAF1/BMP4/ITGA5/ETS2/MAPK7/FZD7/LRP5/BMPR1A/FOXC1/SFRP1/ITGB2/HOXA11/UGDH/MMP15/AMOT 23 BP GO:0001837 epithelial to mesenchymal transition 19/1096 140/18670 0.0005441 0.005222 0.003542 TGFBR3/LOXL2/WWTR1/TGFB2/EPHA3/DAG1/IL1B/SMAD3/PDPN/COL1A1/DLG5/OLFM1/HIF1A/LDLRAD4/BMP4/TWIST1/FOXC1/SFRP1/SPRY1 19 BP GO:0071214 cellular response to abiotic stimulus 35/1096 331/18670 0.0005555 0.005313 0.003604 CRYAB/RELB/EGFR/TNFRSF10B/ADIRF/PCK1/MFAP4/IRF1/GATA3/CD40/DAG1/IL1B/AKR1B1/NAMPT/TP53BP1/MAPK3/GNA11/NFKB1/PTAFR/HSPA5/MYD88/EFHD1/COL1A1/ERCC1/GOT1/AQP1/BAD/MAPK10/HDAC4/MAPK13/TNFSF14/SFRP1/BNIP3/EEF1D/HYAL1 35 BP GO:0104004 cellular response to environmental stimulus 35/1096 331/18670 0.0005555 0.005313 0.003604 CRYAB/RELB/EGFR/TNFRSF10B/ADIRF/PCK1/MFAP4/IRF1/GATA3/CD40/DAG1/IL1B/AKR1B1/NAMPT/TP53BP1/MAPK3/GNA11/NFKB1/PTAFR/HSPA5/MYD88/EFHD1/COL1A1/ERCC1/GOT1/AQP1/BAD/MAPK10/HDAC4/MAPK13/TNFSF14/SFRP1/BNIP3/EEF1D/HYAL1 35 BP GO:0033619 membrane protein proteolysis 11/1096 59/18670 0.0005633 0.005366 0.00364 TNFRSF1B/ADAM19/ADAM8/TIMP4/DAG1/IL1B/NFKB1/TIMP2/CTSH/TIMP3/APOE 11 BP GO:0002922 positive regulation of humoral immune response 6/1096 19/18670 0.0005648 0.005366 0.00364 FCGR2B/IL1B/CCR7/PTPRC/PHB/C6 6 BP GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 6/1096 19/18670 0.0005648 0.005366 0.00364 VEGFA/PRKCB/IL1B/HIF1A/ITGA5/FLT1 6 BP GO:0060231 mesenchymal to epithelial transition 6/1096 19/18670 0.0005648 0.005366 0.00364 GATA3/BMP4/FZD7/BASP1/STAT1/TCF15 6 BP GO:0071229 cellular response to acid chemical 25/1096 209/18670 0.0005691 0.005398 0.003661 LPL/P2RY6/VEGFA/EPHA3/EGFR/SIX1/PCK1/NTRK3/PTK2B/XBP1/ID3/ASS1/PTAFR/COL1A1/ADCY6/PINK1/CDK4/FZD7/CCNB1/AQP1/PTGER2/SFRP1/PDGFRA/COL3A1/COL4A1 25 BP GO:0071624 positive regulation of granulocyte chemotaxis 7/1096 26/18670 0.0005779 0.00547 0.00371 RAC2/CCR7/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 7 BP GO:0045931 positive regulation of mitotic cell cycle 21/1096 163/18670 0.0005786 0.00547 0.00371 PLCB1/MECP2/TGFA/EGFR/CDK10/IL1B/CCND2/CDC25B/BTC/CCND1/INSR/FGFR1/SMARCD3/CDK4/CCNB1/LRP5/LGMN/DUSP3/CUL4A/HYAL1/CDC6 21 BP GO:0007265 Ras protein signal transduction 44/1096 448/18670 0.0005806 0.005479 0.003717 RAC2/SH2B2/RHOH/TGFB2/MAPRE2/RASGRP1/ARHGEF10/RHOBTB3/PSD3/GPSM2/AUTS2/DNMBP/RAB27A/ARHGAP1/RALA/PDPN/RAB29/ARHGDIB/TIMP2/PLK2/TNFAIP1/KANK1/RAPGEF1/F2R/CCNA2/DLC1/PECAM1/NCKAP1/RHOBTB1/APOE/NGF/RAB22A/G3BP1/ABR/AGTR1/ARHGAP5/ARHGEF5/VAV1/NRAS/SPRY1/COL3A1/PSD4/JUN/LAT 44 BP GO:0050671 positive regulation of lymphocyte proliferation 18/1096 130/18670 0.0005915 0.005543 0.00376 CCL5/CORO1A/LILRB2/ADA/CD40/IL1B/GPR183/CD38/PTPRC/CCR2/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/TFRC/IL2RA/IL15 18 BP GO:0007183 SMAD protein complex assembly 5/1096 13/18670 0.0005978 0.005543 0.00376 SMAD3/SMAD1/LDLRAD4/PPM1A/SMAD6 5 BP GO:0031033 myosin filament organization 5/1096 13/18670 0.0005978 0.005543 0.00376 MYH11/MYOM2/TTN/MYBPC2/MYOM1 5 BP GO:0031953 negative regulation of protein autophosphorylation 5/1096 13/18670 0.0005978 0.005543 0.00376 ADIPOQ/ENPP1/GFRA2/PTPRC/JUN 5 BP GO:0034374 low-density lipoprotein particle remodeling 5/1096 13/18670 0.0005978 0.005543 0.00376 LIPC/ABCG1/PLA2G7/APOE/AGTR1 5 BP GO:0035723 interleukin-15-mediated signaling pathway 5/1096 13/18670 0.0005978 0.005543 0.00376 PLCB1/IL15RA/IL2RG/IL2RB/IL15 5 BP GO:0061029 eyelid development in camera-type eye 5/1096 13/18670 0.0005978 0.005543 0.00376 EGFR/HDAC1/TWIST1/OSR2/JUN 5 BP GO:0061042 vascular wound healing 5/1096 13/18670 0.0005978 0.005543 0.00376 TNFAIP3/CXCR4/ADIPOR2/XBP1/SERPINE1 5 BP GO:0071350 cellular response to interleukin-15 5/1096 13/18670 0.0005978 0.005543 0.00376 PLCB1/IL15RA/IL2RG/IL2RB/IL15 5 BP GO:0071352 cellular response to interleukin-2 5/1096 13/18670 0.0005978 0.005543 0.00376 IL2RG/IL2RB/PTK2B/PTPN2/IL2RA 5 BP GO:0007548 sex differentiation 30/1096 270/18670 0.000599 0.005543 0.00376 HOXA10/TGFB2/VEGFA/AXL/SEMA3A/ICAM1/GATA3/ATRX/TCF7/NUPR1/RHOBTB3/BCL2L2/SDC1/RBP4/CCND1/TNFSF10/HSPA5/INSR/AR/ERCC1/LFNG/BASP1/BMPR1A/FOXC1/ASB1/SFRP1/PDGFRA/HOXA11/TYRO3/INHBB 30 BP GO:0045927 positive regulation of growth 30/1096 270/18670 0.000599 0.005543 0.00376 PLCB1/TGFBR3/CXCR4/SEMA5A/TGFB2/VEGFA/EGFR/HBEGF/NTRK3/PTK2B/RFTN1/PAK1/NEDD4L/S100A9/CD38/INSR/FGFR1/SYT17/PIN1/PIM1/EFNA5/DIO3/CCNB1/BASP1/NGF/BMPR1A/CXCL12/SFRP1/WFS1/HYAL1 30 BP GO:0006509 membrane protein ectodomain proteolysis 9/1096 42/18670 0.0006154 0.005685 0.003856 TNFRSF1B/ADAM19/ADAM8/TIMP4/DAG1/IL1B/TIMP2/TIMP3/APOE 9 BP GO:0007435 salivary gland morphogenesis 8/1096 34/18670 0.0006343 0.005841 0.003962 TGFB2/EGFR/SEMA3A/NFIB/DAG1/TGM2/FGFR1/SEMA3C 8 BP GO:0060795 cell fate commitment involved in formation of primary germ layer 8/1096 34/18670 0.0006343 0.005841 0.003962 SMAD1/FGFR1/PAF1/BMP4/ETS2/FZD7/BMPR1A/HOXA11 8 BP GO:0034341 response to interferon-gamma 24/1096 199/18670 0.0006457 0.005937 0.004027 CCL5/CCL13/STXBP1/GSN/ICAM1/FLNB/IRF1/CCL18/GCH1/ASS1/PTAFR/CD44/STXBP2/NMI/IRF8/GBP2/TLR2/STAT1/GBP1/IRF7/PTPN2/CCL2/OAS2/CCL7 24 BP GO:0030183 B cell differentiation 18/1096 131/18670 0.0006489 0.005938 0.004027 ADA/PTK2B/FCGR2B/XBP1/PTPN6/GPR183/KLF6/PTPRC/ITGA4/PLCG2/CD27/LFNG/NCKAP1L/BAD/HDAC4/INPP5D/SFRP1/PTPN2 18 BP GO:0032946 positive regulation of mononuclear cell proliferation 18/1096 131/18670 0.0006489 0.005938 0.004027 CCL5/CORO1A/LILRB2/ADA/CD40/IL1B/GPR183/CD38/PTPRC/CCR2/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/TFRC/IL2RA/IL15 18 BP GO:0010675 regulation of cellular carbohydrate metabolic process 19/1096 142/18670 0.00065 0.005938 0.004027 FOXO1/P2RY6/ADIPOQ/ENPP1/PTK2B/NUPR1/PLEK/SIK1/RGN/PTAFR/PDK2/INSR/DYRK2/NFE2L1/BAD/PHLDA2/HDAC4/DDIT4/PTPN2 19 BP GO:0038094 Fc-gamma receptor signaling pathway 19/1096 142/18670 0.00065 0.005938 0.004027 CD247/FCGR2B/PAK1/MAPK3/DOCK1/PTPRC/MYH2/PLCG2/CD3G/RAPGEF1/FCGR2A/IGKC/NCKAP1/NCKAP1L/IGLV6-57/ARPC3/VAV1/IGLC1/CYFIP2 19 BP GO:0001954 positive regulation of cell-matrix adhesion 10/1096 51/18670 0.0006572 0.005984 0.004059 VEGFA/EMP2/PTK2B/DAG1/SMAD3/CCR7/SKAP1/THY1/NINJ1/SFRP1 10 BP GO:0045668 negative regulation of osteoblast differentiation 10/1096 51/18670 0.0006572 0.005984 0.004059 SMAD3/ID3/ID1/LRP5/IGFBP5/GDF10/HDAC4/TWIST1/SFRP1/SMAD6 10 BP GO:0061387 regulation of extent of cell growth 16/1096 110/18670 0.0006782 0.006158 0.004177 SPP1/SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/PAK1/OLFM1/SEMA3C/SEMA4F/EFNA5/APOE/NGF/CTTN/CXCL12/DPYSL2 16 BP GO:0060562 epithelial tube morphogenesis 34/1096 322/18670 0.0006785 0.006158 0.004177 CXCR4/TGFB2/VEGFA/SEMA3E/SIX1/GATA3/ITGAX/DAG1/SMAD3/PAK1/FZD2/RALA/MAGED1/AR/DLG5/CTSH/CAV3/HOXA5/HIF1A/BMP4/DLC1/LRP5/CTNNBIP1/CXCL10/TWIST1/SFRP1/COBL/SPINT2/HOXA11/ST14/SPRY1/STIL/COL4A1/GLMN 34 BP GO:1903522 regulation of blood circulation 32/1096 297/18670 0.0006835 0.006194 0.004201 TGFB2/EGFR/SEMA3A/ICAM1/ADA/HBEGF/THRA/BIN1/STC1/FXYD1/DES/ADORA3/ADORA1/PLN/GCH1/MYL2/PTAFR/CD38/RGS2/CASQ2/ASPH/MYH7/CAV3/MYL3/AKAP9/F2R/ATP2A1/SNTA1/HDAC4/AGTR1/PTGER2/CHRM3 32 BP GO:0048675 axon extension 17/1096 121/18670 0.0007015 0.006347 0.004305 SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/DCLK1/AUTS2/PAK1/OLFM1/SEMA3C/SEMA4F/APOE/CTTN/CXCL12/LAMB2/NRP2/DPYSL2 17 BP GO:0042476 odontogenesis 18/1096 132/18670 0.0007111 0.006395 0.004338 FOXO1/TGFB2/SDC1/ID3/PAM/ALPL/COL1A1/NFIC/BMP4/HDAC1/AQP1/HTRA1/SERPINE1/BMPR1A/TWIST1/FOXC1/OSR2/PDGFRA 18 BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 18/1096 132/18670 0.0007111 0.006395 0.004338 GSN/TNFRSF10B/LCK/SMAD3/CTSD/DAP/S100A9/TNFSF10/CTSH/CASP4/F2R/DLC1/HIP1/BAD/GRAMD4/NGF/NLRP3/TFAP4 18 BP GO:0072329 monocarboxylic acid catabolic process 18/1096 132/18670 0.0007111 0.006395 0.004338 ECH1/ADIPOQ/FAH/PCK1/CRAT/ECI1/ECHS1/ACADS/HADH/SLC27A2/ALDH5A1/ACOX2/PGD/TWIST1/ALDH3A2/PLA2G15/PCK2/ETFB 18 BP GO:0035282 segmentation 15/1096 100/18670 0.0007113 0.006395 0.004338 EGR2/SEMA3A/MEOX1/SMAD3/SEMA3C/BMP4/LFNG/BASP1/BMPR1A/PLXNA2/FOXC1/SFRP1/NRP2/COBL/TCF15 15 BP GO:0043542 endothelial cell migration 30/1096 273/18670 0.0007186 0.00645 0.004375 CXCL13/MECP2/ANGPT1/LOXL2/SEMA5A/VEGFA/EMP2/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/ID1/EGR3/FGFR1/SASH1/PLK2/GATA2/HIF1A/BMP4/GPX1/PECAM1/APOE/PTP4A3/LGMN/NRP2/ITGB2/ANGPT2/AMOT 30 BP GO:0002758 innate immune response-activating signal transduction 32/1096 298/18670 0.0007238 0.006487 0.0044 FCN1/TNFAIP3/RELB/CLEC10A/IRF1/BIRC3/RFTN1/PAK1/TRIL/NFKBIA/S100A9/NFKB1/LY96/MFHAS1/CD14/CTSL/LILRA2/MYD88/PLCG2/PAK2/PTPN22/GRAMD4/TLR2/IRF7/LBP/TRAF3/LGMN/ITGB2/NRAS/IKBKG/IKBKE/TYRO3 32 BP GO:0014033 neural crest cell differentiation 14/1096 90/18670 0.0007319 0.006549 0.004442 SEMA5A/SEMA3E/SEMA3A/FAM172A/MAPK3/SEMA3C/HIF1A/SEMA4F/BMP4/BMPR1A/TWIST1/FOXC1/SFRP1/NRP2 14 BP GO:0003009 skeletal muscle contraction 9/1096 43/18670 0.0007383 0.006575 0.00446 SYNM/EEF2/TNNT1/TNNC2/MB/MYH7/TNNC1/CAV3/ATP2A1 9 BP GO:0009163 nucleoside biosynthetic process 9/1096 43/18670 0.0007383 0.006575 0.00446 ADA/HPRT1/DCK/NME3/GUK1/IMPDH1/IMPDH2/TYMP/TK2 9 BP GO:0045687 positive regulation of glial cell differentiation 9/1096 43/18670 0.0007383 0.006575 0.00446 TNFRSF1B/SERPINE2/CXCR4/BIN1/ZNF365/DAG1/ASPA/HDAC1/TLR2 9 BP GO:0003148 outflow tract septum morphogenesis 7/1096 27/18670 0.0007411 0.006579 0.004462 PARVA/TGFB2/SEMA3C/BMP4/BMPR1A/NRP2/SMAD6 7 BP GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 7/1096 27/18670 0.0007411 0.006579 0.004462 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0002440 production of molecular mediator of immune response 31/1096 286/18670 0.0007443 0.006598 0.004475 TNFRSF1B/IL4R/ANGPT1/IL7R/TGFB2/CD226/GATA3/CD40/FCGR2B/IL1B/TP53BP1/RBP4/XBP1/MAPK3/TRIL/IL27RA/BATF/PTPRC/GAS6/CCR2/ERCC1/PARP3/TNFRSF4/IGKC/CCR6/TLR2/KDELR1/IGLV6-57/NLRP3/TFRC/ELANE 31 BP GO:0048645 animal organ formation 11/1096 61/18670 0.0007559 0.00669 0.004538 SIX1/SULF1/MAPK3/AR/FGFR1/SMARCD3/BMP4/PIM1/BMPR1A/HOXA11/SPRY1 11 BP GO:0010950 positive regulation of endopeptidase activity 22/1096 178/18670 0.0007662 0.006747 0.004576 GSN/TNFRSF10B/LCK/AIM2/SMAD3/CTSD/DAP/S100A9/TNFSF10/ASPH/CTSH/CASP4/F2R/DLC1/HIP1/BAD/GRAMD4/NGF/NLRP3/TFAP4/LGMN/CYFIP2 22 BP GO:0018105 peptidyl-serine phosphorylation 32/1096 299/18670 0.0007662 0.006747 0.004576 ANGPT1/VEGFA/EGFR/AKT3/NTRK3/PRKCB/DCLK1/PAK1/MAPK3/CD44/CLK1/PAK2/HCLS1/GAS6/PLK2/INPP5F/AKAP9/DYRK2/PINK1/MAP4K1/MAPK7/NTF3/CCNB1/PRKG1/PRKCH/MAPK13/DDIT4/PLK1/TENM1/PFN2/IKBKE/PRKY 32 BP GO:0033630 positive regulation of cell adhesion mediated by integrin 6/1096 20/18670 0.000767 0.006747 0.004576 CCL5/CXCL13/TGFB2/PTPN6/SKAP1/NCKAP1L 6 BP GO:0034104 negative regulation of tissue remodeling 6/1096 20/18670 0.000767 0.006747 0.004576 TNFAIP3/CD38/CSK/ABR/INPP5D/SFRP1 6 BP GO:0110111 negative regulation of animal organ morphogenesis 8/1096 35/18670 0.0007805 0.006854 0.004649 TGFB2/NFIB/GATA3/SULF1/BMP4/DIO3/STAT1/FOXC1 8 BP GO:1903426 regulation of reactive oxygen species biosynthetic process 15/1096 101/18670 0.000791 0.006936 0.004704 HBB/ICAM1/PTK2B/IL1B/SMAD3/RGN/ASS1/RAB27A/INSR/TRAP1/CX3CR1/ZNF205/HDAC4/ITGB2/SLC18A2 15 BP GO:0033209 tumor necrosis factor-mediated signaling pathway 21/1096 167/18670 0.0007974 0.006982 0.004735 TNFAIP3/TNFRSF1B/ADIPOQ/AIM2/PTK2B/BIRC3/CD40/CPNE1/NFKBIA/NOL3/TRAF1/CD27/GAS6/CASP4/TNFRSF4/STAT1/TNFRSF17/TRAF3/TNFSF14/PTPN2/IKBKG 21 BP GO:0016051 carbohydrate biosynthetic process 25/1096 214/18670 0.000806 0.007037 0.004773 FOXO1/P2RY6/ADIPOQ/PPP1R3C/PCK1/ENPP1/PTK2B/AKR1B1/PLEK/RBP4/SIK1/RGN/NFKB1/PTAFR/GOT2/PDK2/INSR/PC/DYRK2/GOT1/PGD/PTPN2/SDS/ALDOA/PCK2 25 BP GO:0019882 antigen processing and presentation 26/1096 226/18670 0.0008062 0.007037 0.004773 RELB/ITGAV/LILRB2/TAP1/ICAM1/CD8A/KIF3B/FCGR2B/DCTN3/RFTN1/CCR7/CTSD/RAB27A/CTSL/CTSH/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/TAPBP/DCTN2/LGMN/NCF2/IKBKG 26 BP GO:0051056 regulation of small GTPase mediated signal transduction 35/1096 338/18670 0.0008103 0.007062 0.00479 ARHGAP12/SIPA1L1/RAC2/SH2B2/RHOH/TGFB2/CDON/MAPRE2/RASGRP1/CHN1/ARHGEF10/PSD3/AUTS2/DNMBP/ARHGAP1/ARHGAP26/ARHGDIB/TIMP2/TNFAIP1/KANK1/RAPGEF1/F2R/DLC1/RHOBTB1/APOE/NGF/ABR/ARHGAP5/ARHGEF5/VAV1/STARD8/SPRY1/COL3A1/PSD4/AMOT 35 BP GO:0042129 regulation of T cell proliferation 20/1096 156/18670 0.0008233 0.007164 0.004859 TNFRSF1B/CCL5/RAC2/CORO1A/LILRB2/IRF1/IL1B/PTPN6/PTPRC/DLG5/CCR2/BMP4/IGFBP2/NCKAP1L/HLA-DMB/CD86/TFRC/IL2RA/IL15/GLMN 20 BP GO:0008064 regulation of actin polymerization or depolymerization 22/1096 179/18670 0.0008263 0.007165 0.00486 TMOD1/CORO1A/SEMA5A/GSN/ICAM1/BIN1/PTK2B/PLEK/CCR7/SPTBN1/HCLS1/CAPG/KANK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/CXCL12/TENM1/PFN2 22 BP GO:0014032 neural crest cell development 13/1096 81/18670 0.0008281 0.007165 0.00486 SEMA5A/SEMA3E/SEMA3A/FAM172A/MAPK3/SEMA3C/HIF1A/SEMA4F/BMP4/BMPR1A/TWIST1/FOXC1/NRP2 13 BP GO:0014855 striated muscle cell proliferation 13/1096 81/18670 0.0008281 0.007165 0.00486 TGFBR3/ANGPT1/TGFB2/SIX1/RBP4/SMAD1/FGFR1/PIM1/CCNB1/BMPR1A/JARID2/FOXC1/RXRA 13 BP GO:0050868 negative regulation of T cell activation 16/1096 112/18670 0.0008285 0.007165 0.00486 RUNX3/IL4R/LILRB2/IRF1/FCGR2B/PTPN6/DLG5/PTPN22/BMP4/LAG3/CD86/DUSP3/PTPN2/IL2RA/PRDX2/GLMN 16 BP GO:0045637 regulation of myeloid cell differentiation 28/1096 251/18670 0.0008428 0.007278 0.004937 ZBTB16/ADIPOQ/PRKCB/PTK2B/TCTA/LILRB4/NFKBIA/MYL9/HCLS1/GATA2/PAF1/HOXA5/HIF1A/HDAC1/NCKAP1L/PF4/STAT1/CTNNBIP1/LILRB3/IRF7/APCS/INPP5D/CNOT4/SFRP1/PTPN2/CUL4A/TRIM58/JUN 28 BP GO:0010769 regulation of cell morphogenesis involved in differentiation 32/1096 301/18670 0.0008575 0.007393 0.005014 SPP1/UST/SIPA1L1/SEMA5A/VEGFA/SEMA3E/SEMA3A/CHN1/NTRK3/CUX1/POSTN/PAK1/NEDD4L/DOCK1/PDPN/ID1/OLFM1/KANK1/SEMA3C/THY1/SEMA4F/EFNA5/GBP1/APOE/NGF/PLXNC1/CTTN/PLXNA2/PDLIM5/CXCL12/CDH2/DPYSL2 32 BP GO:0007411 axon guidance 30/1096 276/18670 0.0008586 0.007393 0.005014 CXCR4/RAC2/EGR2/SEMA5A/VEGFA/EPHA3/SEMA3E/SEMA3A/CHN1/NFIB/GATA3/GFRA2/DAG1/MAPK3/GAB2/SPTBN1/MYH10/SEMA3C/UNC5C/SEMA4F/EFNA5/MAPK7/PLXNC1/PLXNA2/CXCL12/LAMB2/NRP2/DPYSL2/CYFIP2/GAP43 30 BP GO:0050806 positive regulation of synaptic transmission 21/1096 168/18670 0.0008621 0.007411 0.005027 SERPINE2/MECP2/STXBP1/EGFR/LILRB2/CLSTN1/PTK2B/CALB2/SHANK2/ADORA1/CX3CR1/PLK2/CCR2/PINK1/NRGN/UNC13B/APOE/RIMS3/LGMN/CCL2/ADCY1 21 BP GO:0002260 lymphocyte homeostasis 11/1096 62/18670 0.000871 0.007454 0.005056 TNFAIP3/SH2B2/CORO1A/ADA/HIF1A/NCKAP1L/TNFRSF17/TNFSF14/IL2RA/LAT/CCNB2 11 BP GO:0009880 embryonic pattern specification 11/1096 62/18670 0.000871 0.007454 0.005056 ZBTB16/SEMA3A/MEOX1/SMAD3/SMAD1/BASP1/SIM2/NRP2/COBL/SMAD6/STIL 11 BP GO:0045453 bone resorption 11/1096 62/18670 0.000871 0.007454 0.005056 SPP1/TNFAIP3/ADAM8/RAC2/EGFR/PTK2B/S1PR1/CD38/CSK/INPP5D/TFRC 11 BP GO:0035335 peptidyl-tyrosine dephosphorylation 15/1096 102/18670 0.0008781 0.007463 0.005062 DUSP5/PTPN13/PTPN7/PTPN21/CDC25B/PTPN6/PTPRC/DUSP14/PTPN22/DUSP2/PTPRF/PTP4A3/DUSP3/PTPN2/PTPRE 15 BP GO:0010463 mesenchymal cell proliferation 9/1096 44/18670 0.0008805 0.007463 0.005062 VEGFA/SIX1/NFIB/FGFR1/BMP4/LRP5/STAT1/CTNNBIP1/BMPR1A 9 BP GO:0035307 positive regulation of protein dephosphorylation 9/1096 44/18670 0.0008805 0.007463 0.005062 MAGI2/LILRB2/ADORA1/PTPRC/CDH5/PIN1/PINK1/DLC1/CAMTA1 9 BP GO:0035850 epithelial cell differentiation involved in kidney development 9/1096 44/18670 0.0008805 0.007463 0.005062 MAGI2/WWTR1/ADIPOQ/GATA3/ACTA2/BMP4/BASP1/STAT1/LAMB2 9 BP GO:0030240 skeletal muscle thin filament assembly 5/1096 14/18670 0.0008852 0.007463 0.005062 MYOM2/ACTA1/TTN/MYBPC2/MYOM1 5 BP GO:0045064 T-helper 2 cell differentiation 5/1096 14/18670 0.0008852 0.007463 0.005062 IL4R/GATA3/BATF/CD86/NLRP3 5 BP GO:0050862 positive regulation of T cell receptor signaling pathway 5/1096 14/18670 0.0008852 0.007463 0.005062 LCK/CD226/ADA/CCR7/RAB29 5 BP GO:0070669 response to interleukin-2 5/1096 14/18670 0.0008852 0.007463 0.005062 IL2RG/IL2RB/PTK2B/PTPN2/IL2RA 5 BP GO:0070672 response to interleukin-15 5/1096 14/18670 0.0008852 0.007463 0.005062 PLCB1/IL15RA/IL2RG/IL2RB/IL15 5 BP GO:1901070 guanosine-containing compound biosynthetic process 5/1096 14/18670 0.0008852 0.007463 0.005062 HPRT1/NME3/GUK1/IMPDH1/IMPDH2 5 BP GO:0032715 negative regulation of interleukin-6 production 10/1096 53/18670 0.0009017 0.007579 0.005141 TNFAIP3/CD200/SLAMF1/PTPN6/IL27RA/GAS6/PTPN22/NCKAP1L/CSK/INPP5D 10 BP GO:1905517 macrophage migration 10/1096 53/18670 0.0009017 0.007579 0.005141 CCL5/RARRES2/CD200/PTK2B/MAPK3/CX3CR1/CCR2/MTUS1/C3AR1/CCL2 10 BP GO:0043112 receptor metabolic process 23/1096 192/18670 0.0009092 0.007619 0.005168 MAGI2/GPRASP1/ANGPT1/VEGFA/ITGAV/ADIPOQ/SFRP4/CXCL8/RAB29/PLCG2/DNM1/INPP5F/CAV3/HOXA5/HIF1A/NTF3/HDAC1/CAMLG/USP46/APOE/TFRC/LGMN/ITGB2 23 BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 23/1096 192/18670 0.0009092 0.007619 0.005168 CCL5/ANGPT1/TGFA/VEGFA/ADIPOQ/ICAM1/HBEGF/PTK2B/CD40/ADORA1/CD44/PTPRC/PAK2/HCLS1/GAS6/ITGA5/EFNA5/PECAM1/NTF3/THBS4/FGFR3/CRLF1/IL15 23 BP GO:0097485 neuron projection guidance 30/1096 277/18670 0.0009103 0.007619 0.005168 CXCR4/RAC2/EGR2/SEMA5A/VEGFA/EPHA3/SEMA3E/SEMA3A/CHN1/NFIB/GATA3/GFRA2/DAG1/MAPK3/GAB2/SPTBN1/MYH10/SEMA3C/UNC5C/SEMA4F/EFNA5/MAPK7/PLXNC1/PLXNA2/CXCL12/LAMB2/NRP2/DPYSL2/CYFIP2/GAP43 30 BP GO:0019319 hexose biosynthetic process 14/1096 92/18670 0.000915 0.007642 0.005183 FOXO1/ADIPOQ/PCK1/AKR1B1/RBP4/SIK1/GOT2/PDK2/PC/GOT1/PTPN2/SDS/ALDOA/PCK2 14 BP GO:2000241 regulation of reproductive process 19/1096 146/18670 0.0009158 0.007642 0.005183 PLCB1/STXBP1/HPGDS/SEMA3A/ADA/NUPR1/SULF1/CDC25B/PTAFR/INSR/ARHGDIB/AR/BMP4/LFNG/PHLDA2/HDAC4/SFRP1/RXRA/INHBB 19 BP GO:0035265 organ growth 24/1096 204/18670 0.0009196 0.007662 0.005197 TGFBR3/DDR2/TGFB2/SORBS2/STC1/PAK1/S1PR1/RBP4/RGS2/SMAD1/AR/FGFR1/CAV3/PIN1/PIM1/CCNB1/BASP1/BMPR1A/PDLIM5/JARID2/FOXC1/CARM1/FGFR3/RXRA 24 BP GO:0014013 regulation of gliogenesis 17/1096 124/18670 0.0009294 0.00773 0.005243 TNFRSF1B/SERPINE2/CXCR4/NTRK3/BIN1/ZNF365/DAG1/IL1B/GPR183/CX3CR1/CCR2/ASPA/ID4/HDAC1/TLR2/PRKCH/CDH2 17 BP GO:0051100 negative regulation of binding 21/1096 169/18670 0.0009313 0.00773 0.005243 ADIPOQ/SLPI/CPNE1/MAPK3/PLN/ID3/NFKBIA/GZMA/HSPA5/PEX19/ITGA4/ID1/PIN1/ID4/PIM2/CTNNBIP1/PTPRF/CARM1/TFAP4/TFIP11/JUN 21 BP GO:0051702 interaction with symbiont 13/1096 82/18670 0.0009323 0.00773 0.005243 CCL5/PC/CXCL6/GPX1/HDAC1/AQP1/PF4/APOE/APCS/TFAP4/VAPA/ELANE/JUN 13 BP GO:0034368 protein-lipid complex remodeling 7/1096 28/18670 0.0009385 0.00773 0.005243 LPL/LIPC/ABCG1/APOC1/PLA2G7/APOE/AGTR1 7 BP GO:0034369 plasma lipoprotein particle remodeling 7/1096 28/18670 0.0009385 0.00773 0.005243 LPL/LIPC/ABCG1/APOC1/PLA2G7/APOE/AGTR1 7 BP GO:0043501 skeletal muscle adaptation 7/1096 28/18670 0.0009385 0.00773 0.005243 TNNT1/MYH7/TNNC1/ACTA1/TNNI1/IGFBP5/IL15 7 BP GO:0045577 regulation of B cell differentiation 7/1096 28/18670 0.0009385 0.00773 0.005243 XBP1/PTPN6/CD27/NCKAP1L/BAD/INPP5D/SFRP1 7 BP GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 7/1096 28/18670 0.0009385 0.00773 0.005243 ICAM1/PTAFR/ITGA4/CCR2/CXCL12/ITGB2/ELANE 7 BP GO:0030224 monocyte differentiation 8/1096 36/18670 0.0009525 0.007788 0.005282 VEGFA/MT1G/BMP4/CTNNBIP1/IRF7/APCS/INPP5D/JUN 8 BP GO:0033762 response to glucagon 8/1096 36/18670 0.0009525 0.007788 0.005282 PCK1/ADCY9/ASS1/ADCY6/CDO1/CCNA2/QDPR/ADCY1 8 BP GO:0071709 membrane assembly 8/1096 36/18670 0.0009525 0.007788 0.005282 MAGI2/ANK3/EMP2/UGCG/RFTN1/SPTBN1/CAV3/CDH2 8 BP GO:1902622 regulation of neutrophil migration 8/1096 36/18670 0.0009525 0.007788 0.005282 ADAM8/RAC2/CCR7/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 8 BP GO:1903131 mononuclear cell differentiation 8/1096 36/18670 0.0009525 0.007788 0.005282 VEGFA/MT1G/BMP4/CTNNBIP1/IRF7/APCS/INPP5D/JUN 8 BP GO:0002637 regulation of immunoglobulin production 11/1096 63/18670 0.001 0.008167 0.005539 IL4R/CD40/FCGR2B/TP53BP1/RBP4/XBP1/IL27RA/PTPRC/PARP3/TNFRSF4/TFRC 11 BP GO:0030900 forebrain development 38/1096 381/18670 0.001006 0.008192 0.005556 PLCB1/EZH1/CXCR4/SEMA5A/CDON/EGFR/AXL/SEMA3A/NFIB/DCLK1/ATRX/BTG2/PITX1/MYH10/HPRT1/FGFR1/GATA2/HIF1A/NRGN/ID4/BMP4/DLC1/TACC2/HDAC1/AQP1/BAD/BCL2A1/PRKG1/BMPR1A/CXCL12/CDH2/NRP2/GNG12/BNIP3/COL3A1/TYRO3/STIL/ATF5 38 BP GO:0030282 bone mineralization 16/1096 114/18670 0.001006 0.008192 0.005556 DDR2/SRGN/ENPP1/PTK2B/SMAD3/S1PR1/MGP/NELL1/PTHLH/HIF1A/BMP4/MINPP1/BMPR1A/TWIST1/FGFR3/OSR2 16 BP GO:0009063 cellular amino acid catabolic process 17/1096 125/18670 0.001018 0.00823 0.005582 ALDH6A1/FAH/GOT2/HPD/BCAT1/BCKDHA/CDO1/HDC/ALDH5A1/ASPA/PCBD1/GOT1/AHCY/QDPR/CRYM/TST/SDS 17 BP GO:0001779 natural killer cell differentiation 6/1096 21/18670 0.001021 0.00823 0.005582 AXL/RASGRP1/PTPRC/GAS6/TYRO3/IL15 6 BP GO:0009713 catechol-containing compound biosynthetic process 6/1096 21/18670 0.001021 0.00823 0.005582 TGFB2/GATA3/GCH1/HDC/PNMT/MOXD1 6 BP GO:0035455 response to interferon-alpha 6/1096 21/18670 0.001021 0.00823 0.005582 IFNAR2/AXL/GATA3/GAS6/LAMP3/MX2 6 BP GO:0042423 catecholamine biosynthetic process 6/1096 21/18670 0.001021 0.00823 0.005582 TGFB2/GATA3/GCH1/HDC/PNMT/MOXD1 6 BP GO:0045061 thymic T cell selection 6/1096 21/18670 0.001021 0.00823 0.005582 CD3D/GATA3/CCR7/PTPRC/CD3G/PTPN2 6 BP GO:0140131 positive regulation of lymphocyte chemotaxis 6/1096 21/18670 0.001021 0.00823 0.005582 CCL5/CXCL13/PTK2B/CCR2/TNFSF14/CCL7 6 BP GO:1903524 positive regulation of blood circulation 12/1096 73/18670 0.001044 0.008408 0.005703 TGFB2/EGFR/ICAM1/ADA/GCH1/PTAFR/CD38/RGS2/F2R/ATP2A1/PTGER2/CHRM3 12 BP GO:0005996 monosaccharide metabolic process 31/1096 292/18670 0.001048 0.008411 0.005705 FOXO1/ADIPOQ/SLC2A3/PCK1/ENPP1/AKR1B1/PFKM/HK2/RBP4/SIK1/RGN/SLC23A2/CYB5R3/MAN2B2/GOT2/PDK2/INSR/PC/ALDH5A1/DYRK2/GOT1/NFE2L1/LRP5/MPI/BAD/PGD/PHLDA2/PTPN2/SDS/ALDOA/PCK2 31 BP GO:0006584 catecholamine metabolic process 10/1096 54/18670 0.001049 0.008411 0.005705 MAOA/TGFB2/GATA3/AKR1B1/GCH1/HPRT1/HDC/PNMT/MOXD1/ITGB2 10 BP GO:0009712 catechol-containing compound metabolic process 10/1096 54/18670 0.001049 0.008411 0.005705 MAOA/TGFB2/GATA3/AKR1B1/GCH1/HPRT1/HDC/PNMT/MOXD1/ITGB2 10 BP GO:0071559 response to transforming growth factor beta 28/1096 255/18670 0.001076 0.008611 0.00584 RUNX3/TGFBR3/SOX5/TGFB2/MXRA5/POSTN/SMAD3/HSPA5/CDH5/SMAD1/ID1/COL1A1/CX3CR1/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/MAPK7/HTRA1/GDF10/BMPR1A/SFRP1/PPM1A/COL3A1/SMAD6/ADAMTSL2/JUN 28 BP GO:0061041 regulation of wound healing 19/1096 148/18670 0.00108 0.008636 0.005858 TNFAIP3/SERPINE2/CXCR4/HBEGF/PLEK/SMAD3/XBP1/PDPN/TFPI/KANK1/F2R/PLAUR/PRKG1/APOE/SERPINE1/APCS/PDGFRA/PRDX2/SELP 19 BP GO:0038061 NIK/NF-kappaB signaling 22/1096 183/18670 0.001109 0.008855 0.006006 LITAF/RELB/EGFR/TNFRSF10B/BIRC3/CPNE1/NFKB2/IL1B/NR3C2/NFKBIA/NOL3/CHI3L1/CD14/CD27/SASH1/PTPN22/TLR2/NLRP3/PTP4A3/TNFSF14/PPM1A/IKBKE 22 BP GO:0045667 regulation of osteoblast differentiation 17/1096 126/18670 0.001114 0.00888 0.006023 DDR2/ZHX3/SMAD3/NELL1/ID3/SMAD1/ID1/BMP4/LRP5/IGFBP5/CTNNBIP1/GDF10/HDAC4/BMPR1A/TWIST1/SFRP1/SMAD6 17 BP GO:0007519 skeletal muscle tissue development 20/1096 160/18670 0.001132 0.008995 0.006101 EGR2/CDON/MYL6B/HLF/SIX1/SVIL/FLNB/NUPR1/EEF2/BTG2/PITX1/SRPK3/KCNAB1/MYOM2/ACTA1/GPX1/HDAC4/TWIST1/MAFF/MYOM1 20 BP GO:0046661 male sex differentiation 20/1096 160/18670 0.001132 0.008995 0.006101 HOXA10/TGFB2/SEMA3A/ICAM1/GATA3/ATRX/NUPR1/RHOBTB3/BCL2L2/SDC1/CCND1/TNFSF10/INSR/AR/ERCC1/BMPR1A/ASB1/SFRP1/PDGFRA/HOXA11 20 BP GO:0070167 regulation of biomineral tissue development 14/1096 94/18670 0.001135 0.009011 0.006112 DDR2/SRGN/ENPP1/PTK2B/SMAD3/S1PR1/MGP/NELL1/GAS6/HIF1A/BMP4/BMPR1A/TWIST1/OSR2 14 BP GO:0002218 activation of innate immune response 33/1096 319/18670 0.001145 0.009042 0.006133 FCN1/TNFAIP3/RELB/CLEC10A/IRF1/AIM2/BIRC3/RFTN1/PAK1/TRIL/NFKBIA/S100A9/NFKB1/LY96/MFHAS1/CD14/CTSL/LILRA2/MYD88/PLCG2/PAK2/PTPN22/GRAMD4/TLR2/IRF7/LBP/TRAF3/LGMN/ITGB2/NRAS/IKBKG/IKBKE/TYRO3 33 BP GO:0002228 natural killer cell mediated immunity 11/1096 64/18670 0.001145 0.009042 0.006133 CORO1A/GZMB/RASGRP1/CD226/SH2D1A/PTPN6/RAB27A/CRTAM/LAG3/VAV1/KLRD1 11 BP GO:0050922 negative regulation of chemotaxis 11/1096 64/18670 0.001145 0.009042 0.006133 CXCL13/SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F/DUSP3/PTPN2/ANGPT2/CCL2/ELANE 11 BP GO:0003156 regulation of animal organ formation 8/1096 37/18670 0.001154 0.009042 0.006133 SIX1/SULF1/AR/FGFR1/BMP4/PIM1/HOXA11/SPRY1 8 BP GO:0030212 hyaluronan metabolic process 8/1096 37/18670 0.001154 0.009042 0.006133 IL1B/NFKB1/CD44/PIM1/ABCC5/HEXA/HYAL1/IL15 8 BP GO:0038083 peptidyl-tyrosine autophosphorylation 8/1096 37/18670 0.001154 0.009042 0.006133 VEGFA/EGFR/ITK/LCK/PTK2B/MAPK3/INSR/SLA 8 BP GO:0048846 axon extension involved in axon guidance 8/1096 37/18670 0.001154 0.009042 0.006133 SEMA5A/VEGFA/SEMA3E/SEMA3A/SEMA3C/SEMA4F/CXCL12/NRP2 8 BP GO:1902284 neuron projection extension involved in neuron projection guidance 8/1096 37/18670 0.001154 0.009042 0.006133 SEMA5A/VEGFA/SEMA3E/SEMA3A/SEMA3C/SEMA4F/CXCL12/NRP2 8 BP GO:2000249 regulation of actin cytoskeleton reorganization 8/1096 37/18670 0.001154 0.009042 0.006133 SEMA3E/NTRK3/PTK2B/HCLS1/ARHGDIB/NTF3/GMFG/PDGFRA 8 BP GO:0048880 sensory system development 37/1096 371/18670 0.001165 0.009123 0.006188 TMOD1/CRYAB/TGFB2/VEGFA/CDON/EGFR/SEMA3A/GATA3/NTRK3/SMAD3/RBP4/MYH10/MYOM2/SMARCD3/HIF1A/THY1/ATF6/BMP4/CDK4/B9D1/DIO3/HDAC1/LRP5/EFEMP1/JMJD6/NINJ1/TWIST1/LAMB2/FOXC1/OSR2/PDGFRA/IMPDH2/RING1/MYOM1/RXRA/COL4A1/JUN 37 BP GO:0034367 protein-containing complex remodeling 7/1096 29/18670 0.001175 0.009161 0.006214 LPL/LIPC/ABCG1/APOC1/PLA2G7/APOE/AGTR1 7 BP GO:0035666 TRIF-dependent toll-like receptor signaling pathway 7/1096 29/18670 0.001175 0.009161 0.006214 BIRC3/LY96/CD14/IRF7/TRAF3/IKBKG/IKBKE 7 BP GO:0072606 interleukin-8 secretion 7/1096 29/18670 0.001175 0.009161 0.006214 FCN1/CD2/CHI3L1/CD14/PTPN22/F2R/TLR2 7 BP GO:0014015 positive regulation of gliogenesis 12/1096 74/18670 0.001181 0.009184 0.006229 TNFRSF1B/SERPINE2/CXCR4/BIN1/ZNF365/DAG1/IL1B/CCR2/ASPA/HDAC1/TLR2/PRKCH 12 BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 12/1096 74/18670 0.001181 0.009184 0.006229 ADIPOQ/PTPRC/PIN1/RAPGEF1/PHB/TIMP3/GBP1/LMO3/CSK/DUSP3/PTPN2/SPRY1 12 BP GO:0050864 regulation of B cell activation 22/1096 184/18670 0.001192 0.009254 0.006277 TRBC1/TNFAIP3/ADA/CD40/FCGR2B/TP53BP1/XBP1/PTPN6/GPR183/IL27RA/CD38/PTPRC/CD27/PARP3/TNFRSF4/IGKC/NCKAP1L/BAD/INPP5D/TFRC/IGLC1/SFRP1 22 BP GO:0008584 male gonad development 18/1096 138/18670 0.001202 0.009317 0.00632 HOXA10/TGFB2/SEMA3A/ICAM1/GATA3/ATRX/NUPR1/RHOBTB3/BCL2L2/SDC1/CCND1/TNFSF10/INSR/AR/ERCC1/SFRP1/PDGFRA/HOXA11 18 BP GO:0043113 receptor clustering 10/1096 55/18670 0.001216 0.009416 0.006387 MAGI2/ITGB7/GSN/ITGAL/ITGA4/THY1/APOE/GLRB/CDH2/ITGB2 10 BP GO:0002437 inflammatory response to antigenic stimulus 9/1096 46/18670 0.001231 0.009483 0.006432 RASGRP1/ICAM1/GATA3/FCGR2B/CCR7/GPX1/AHCY/IL2RA/ELANE 9 BP GO:0033628 regulation of cell adhesion mediated by integrin 9/1096 46/18670 0.001231 0.009483 0.006432 CCL5/CXCL13/TGFB2/ADA/PTPN6/SKAP1/NCKAP1L/SERPINE1/LPXN 9 BP GO:0043277 apoptotic cell clearance 9/1096 46/18670 0.001231 0.009483 0.006432 FCN1/ITGAV/AXL/TGM2/GAS6/JMJD6/RHOBTB1/CCL2/TYRO3 9 BP GO:0050919 negative chemotaxis 9/1096 46/18670 0.001231 0.009483 0.006432 SEMA5A/ITGAV/SEMA3E/SEMA3A/SEMA3C/UNC5C/SEMA4F/EFNA5/NRP2 9 BP GO:0046851 negative regulation of bone remodeling 5/1096 15/18670 0.001264 0.009695 0.006575 TNFAIP3/CD38/CSK/INPP5D/SFRP1 5 BP GO:2000484 positive regulation of interleukin-8 secretion 5/1096 15/18670 0.001264 0.009695 0.006575 FCN1/CD2/CD14/F2R/TLR2 5 BP GO:2001028 positive regulation of endothelial cell chemotaxis 5/1096 15/18670 0.001264 0.009695 0.006575 SEMA5A/VEGFA/HSPB1/FGFR1/LGMN 5 BP GO:0050777 negative regulation of immune response 19/1096 150/18670 0.00127 0.009713 0.006588 TNFAIP3/IL4R/ANGPT1/IL7R/TGFB2/FCGR2B/PTPN6/IL27RA/PTPRC/CCR2/NMI/GPX1/PARP3/ABR/INPP5D/PTPN2/IL2RA/COL3A1/TYRO3 19 BP GO:0071774 response to fibroblast growth factor 19/1096 150/18670 0.00127 0.009713 0.006588 CCL5/CXCL13/GATA3/POSTN/SULF1/MAPK3/CXCL8/CD44/EGR3/COL1A1/FGFR1/POLR2E/POLR2I/SFRP1/FGFR3/CCL2/SPRY1/IER2/HYAL1 19 BP GO:0030336 negative regulation of cell migration 34/1096 334/18670 0.001281 0.009782 0.006635 PLCB1/MAGI2/CXCL13/MECP2/CD200/ADIPOQ/SEMA3A/ADA/STC1/DAG1/SULF1/ADORA3/ADORA1/IL27RA/CX3CR1/ARHGDIB/DLG5/KANK1/THY1/LDLRAD4/DLC1/IGFBP5/PRKG1/APOE/SERPINE1/BMPR1A/CXCL12/ABR/SFRP1/DUSP3/ANGPT2/CCL2/PFN2/COL3A1 34 BP GO:0006006 glucose metabolic process 24/1096 209/18670 0.001289 0.009819 0.00666 FOXO1/ADIPOQ/PCK1/ENPP1/PFKM/HK2/RBP4/SIK1/RGN/GOT2/PDK2/INSR/PC/ALDH5A1/DYRK2/GOT1/NFE2L1/LRP5/BAD/PHLDA2/PTPN2/SDS/ALDOA/PCK2 24 BP GO:0008154 actin polymerization or depolymerization 24/1096 209/18670 0.001289 0.009819 0.00666 TMOD1/CORO1A/SEMA5A/GSN/ICAM1/BIN1/PTK2B/PLEK/CCR7/SPTBN1/HCLS1/CAPG/KANK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/CXCL12/PSTPIP1/COBL/TENM1/PFN2 24 BP GO:0046546 development of primary male sexual characteristics 18/1096 139/18670 0.001307 0.009927 0.006733 HOXA10/TGFB2/SEMA3A/ICAM1/GATA3/ATRX/NUPR1/RHOBTB3/BCL2L2/SDC1/CCND1/TNFSF10/INSR/AR/ERCC1/SFRP1/PDGFRA/HOXA11 18 BP GO:0070665 positive regulation of leukocyte proliferation 18/1096 139/18670 0.001307 0.009927 0.006733 CCL5/CORO1A/LILRB2/ADA/CD40/IL1B/GPR183/CD38/PTPRC/CCR2/IGFBP2/TNFRSF4/NCKAP1L/HLA-DMB/CD86/TFRC/IL2RA/IL15 18 BP GO:0007052 mitotic spindle organization 15/1096 106/18670 0.001312 0.009934 0.006738 MECP2/EML1/ARHGEF10/KIF3B/GPSM2/PLK2/PARP3/TACC2/CCNB1/MAP4/TPX2/DCTN2/PLK1/SPICE1/STIL 15 BP GO:0042136 neurotransmitter biosynthetic process 15/1096 106/18670 0.001312 0.009934 0.006738 HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/INSR/CX3CR1/HDC/MOXD1/NQO1/ITGB2 15 BP GO:0014031 mesenchymal cell development 13/1096 85/18670 0.001313 0.009934 0.006738 SEMA5A/SEMA3E/SEMA3A/FAM172A/MAPK3/SEMA3C/HIF1A/SEMA4F/BMP4/BMPR1A/TWIST1/FOXC1/NRP2 13 BP GO:1901617 organic hydroxy compound biosynthetic process 29/1096 271/18670 0.001324 0.01 0.006785 PLCB1/P2RY6/TGFB2/CH25H/PCK1/GATA3/PTK2B/IL1B/AKR1B1/CYB5R1/PLEK/GCH1/CYB5R3/NFKB1/PTAFR/ABCG1/PLCG2/SLC27A2/HDC/PNMT/PCBD1/ACOX2/GOT1/MOXD1/LBR/PMVK/APOE/QDPR/PCK2 29 BP GO:0007422 peripheral nervous system development 12/1096 75/18670 0.001333 0.01006 0.006822 RUNX3/EGR2/NDRG1/NTRK3/ARHGEF10/DAG1/SLC5A3/EGR3/NTF3/NGF/LAMB2/ALDH3A2 12 BP GO:0001759 organ induction 6/1096 22/18670 0.001335 0.01006 0.006824 SIX1/AR/FGFR1/BMP4/HOXA11/SPRY1 6 BP GO:0018209 peptidyl-serine modification 33/1096 322/18670 0.001339 0.01008 0.006836 ANGPT1/VEGFA/SPOCK2/EGFR/AKT3/NTRK3/PRKCB/DCLK1/PAK1/MAPK3/CD44/CLK1/PAK2/HCLS1/GAS6/PLK2/INPP5F/AKAP9/DYRK2/PINK1/MAP4K1/MAPK7/NTF3/CCNB1/PRKG1/PRKCH/MAPK13/DDIT4/PLK1/TENM1/PFN2/IKBKE/PRKY 33 BP GO:0031331 positive regulation of cellular catabolic process 36/1096 361/18670 0.00135 0.01015 0.006886 FOXO1/TNFAIP3/TNFRSF1B/ZBTB20/FTO/ADAM8/PIP4K2B/PTK2B/NUPR1/IL1B/HK2/MAPK3/BTG2/RGN/RNF144A/CTSC/CNOT1/TRIB2/MID2/INSR/PLK2/CAV3/HIF1A/PINK1/BAD/PIM2/APOE/KAT5/TWIST1/PLK1/BNIP3/USP5/IKBKG/HERPUD1/PTTG1IP/SUPT5H 36 BP GO:0030308 negative regulation of cell growth 22/1096 186/18670 0.001373 0.01031 0.006992 SPP1/SERPINE2/CRYAB/SEMA5A/TGFB2/SEMA3E/SEMA3A/ENPP1/ADIPOR2/SMAD3/PAK1/MYL2/RGS2/CDKN2C/CAV3/SEMA3C/SEMA4F/PHB/SFRP1/FHL1/TSPYL2/HYAL1 22 BP GO:0007163 establishment or maintenance of cell polarity 24/1096 210/18670 0.001376 0.01032 0.006999 UST/PARVA/RHOH/GSN/GATA3/PTK2B/RHOBTB3/GPSM2/CCR7/PAK1/DST/CDH5/CD3G/DLG5/KANK1/AQP1/NCKAP1L/MAP4/AMOTL2/PLK1/SPINT2/SPRY1/TCF15/AMOT 24 BP GO:0032755 positive regulation of interleukin-6 production 14/1096 96/18670 0.001398 0.01047 0.007102 ZBTB20/LPL/IL1RN/LILRB2/IL1B/XBP1/PTAFR/LILRA2/MYD88/F2R/TLR2/MAPK13/LBP/TWIST1 14 BP GO:0060688 regulation of morphogenesis of a branching structure 10/1096 56/18670 0.001404 0.0105 0.007121 VEGFA/SIX1/SULF1/MAGED1/AR/FGFR1/CAV3/BMP4/SFRP1/RXRA 10 BP GO:0001654 eye development 36/1096 362/18670 0.001417 0.01058 0.007179 TMOD1/CRYAB/TGFB2/VEGFA/CDON/EGFR/GATA3/NTRK3/SMAD3/RBP4/MYH10/MYOM2/SMARCD3/HIF1A/THY1/ATF6/BMP4/CDK4/B9D1/DIO3/HDAC1/LRP5/EFEMP1/JMJD6/NINJ1/TWIST1/LAMB2/FOXC1/OSR2/PDGFRA/IMPDH2/RING1/MYOM1/RXRA/COL4A1/JUN 36 BP GO:0046330 positive regulation of JNK cascade 18/1096 140/18670 0.001419 0.01058 0.007179 PLCB1/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAP3K4/MFHAS1/CD27/SASH1/MAP4K1/FZD7/ARHGEF5 18 BP GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 9/1096 47/18670 0.001445 0.01067 0.007235 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0002208 somatic diversification of immunoglobulins involved in immune response 9/1096 47/18670 0.001445 0.01067 0.007235 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0043303 mast cell degranulation 9/1096 47/18670 0.001445 0.01067 0.007235 IL4R/RAC2/STXBP1/RASGRP1/GAB2/GATA2/STXBP2/S100A13/LAT 9 BP GO:0045190 isotype switching 9/1096 47/18670 0.001445 0.01067 0.007235 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0061383 trabecula morphogenesis 9/1096 47/18670 0.001445 0.01067 0.007235 TGFBR3/TGFB2/S1PR1/RBP4/COL1A1/CAV3/UBE4B/BMPR1A/SFRP1 9 BP GO:0070231 T cell apoptotic process 9/1096 47/18670 0.001445 0.01067 0.007235 CCL5/ADAM8/IL7R/ADA/CD27/HIF1A/BMP4/KDELR1/IL2RA 9 BP GO:1901659 glycosyl compound biosynthetic process 9/1096 47/18670 0.001445 0.01067 0.007235 ADA/HPRT1/DCK/NME3/GUK1/IMPDH1/IMPDH2/TYMP/TK2 9 BP GO:1903115 regulation of actin filament-based movement 9/1096 47/18670 0.001445 0.01067 0.007235 BIN1/STC1/ADORA1/PLN/PDPN/TNNC1/CAV3/AKAP9/ATP2A1 9 BP GO:0046165 alcohol biosynthetic process 21/1096 175/18670 0.001455 0.01071 0.007262 PLCB1/P2RY6/PCK1/PTK2B/IL1B/AKR1B1/PLEK/GCH1/CYB5R3/NFKB1/PTAFR/ABCG1/PLCG2/PCBD1/GOT1/MOXD1/LBR/PMVK/APOE/QDPR/PCK2 21 BP GO:0032743 positive regulation of interleukin-2 production 7/1096 30/18670 0.001456 0.01071 0.007262 IL1B/SPTBN1/PTPRC/CD83/CCR2/CD86/GLMN 7 BP GO:0090022 regulation of neutrophil chemotaxis 7/1096 30/18670 0.001456 0.01071 0.007262 RAC2/CCR7/CXCL8/NCKAP1L/LBP/THBS4/C3AR1 7 BP GO:0060291 long-term synaptic potentiation 13/1096 86/18670 0.001465 0.01076 0.007297 SERPINE2/MECP2/LILRB2/PTK2B/CALB2/SHANK2/ADORA1/CX3CR1/PLK2/NRGN/APOE/LGMN/ADCY1 13 BP GO:0045861 negative regulation of proteolysis 36/1096 363/18670 0.001487 0.01091 0.007398 SERPINE2/CRYAB/VEGFA/SPOCK2/SLPI/SERPINA1/TIMP4/BIN1/BIRC3/RARRES1/APLP2/NOL3/CD44/CST7/PAK2/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/LAMP3/GAS1/GPX1/PLAUR/AQP1/TIMP3/CAMLG/UBE2J1/USP7/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2/HERPUD1 36 BP GO:0006942 regulation of striated muscle contraction 14/1096 97/18670 0.001548 0.01134 0.007689 BIN1/STC1/ADORA1/PLN/MYL2/RGS2/CASQ2/MYH7/CAV3/MYL3/AKAP9/TNNI1/ATP2A1/HDAC4 14 BP GO:0019318 hexose metabolic process 27/1096 249/18670 0.001573 0.01151 0.007807 FOXO1/ADIPOQ/PCK1/ENPP1/AKR1B1/PFKM/HK2/RBP4/SIK1/RGN/MAN2B2/GOT2/PDK2/INSR/PC/ALDH5A1/DYRK2/GOT1/NFE2L1/LRP5/MPI/BAD/PHLDA2/PTPN2/SDS/ALDOA/PCK2 27 BP GO:0009062 fatty acid catabolic process 15/1096 108/18670 0.001589 0.01161 0.007874 ECH1/ADIPOQ/PCK1/CRAT/ECI1/ECHS1/ACADS/HADH/SLC27A2/ACOX2/TWIST1/ALDH3A2/PLA2G15/PCK2/ETFB 15 BP GO:0042133 neurotransmitter metabolic process 19/1096 153/18670 0.001606 0.01172 0.00795 MAOA/HBB/GCHFR/ICAM1/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/INSR/CX3CR1/HDC/ALDH5A1/MOXD1/NQO1/TLR2/ITGB2/SDS 19 BP GO:0060760 positive regulation of response to cytokine stimulus 10/1096 57/18670 0.001615 0.01175 0.00797 CXCR4/AXL/CPNE1/GAS6/CASP4/HIF1A/TLR2/IRF7/AGPAT1/IKBKE 10 BP GO:0071398 cellular response to fatty acid 10/1096 57/18670 0.001615 0.01175 0.00797 LPL/P2RY6/ID3/ASS1/PTAFR/ADCY6/CDK4/CCNB1/PTGER2/SFRP1 10 BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 13/1096 87/18670 0.001632 0.01186 0.008044 CCL5/ANGPT1/TGFB2/NTRK3/PTPN6/INSR/HCLS1/FGFR1/F2R/NTF3/PDGFRA/SELP/FLT1 13 BP GO:0031667 response to nutrient levels 46/1096 499/18670 0.001652 0.01196 0.008114 SPP1/FOXO1/LPL/GSN/EGFR/ADIPOQ/PCK1/ICAM1/ADA/STC1/IL1B/EEF2/NAMPT/POSTN/ADIPOR2/XBP1/MAPK3/SIK1/DAP/ASS1/CCND1/ALPL/HSPA5/PDK2/COL1A1/GABARAPL1/OXCT1/GAS6/ERCC1/PIM1/IGFBP2/NQO1/AHCY/EHMT2/HSD11B2/STAT1/APOE/CXCL10/WDR45/SFRP1/NPRL3/INHBB/PCK2/IL15/JUN/MBD2 46 BP GO:0014741 negative regulation of muscle hypertrophy 8/1096 39/18670 0.001656 0.01196 0.008114 FOXO1/TNFRSF1B/SMAD3/PAK1/RGS2/CAV3/IGFBP5/JARID2 8 BP GO:0048713 regulation of oligodendrocyte differentiation 8/1096 39/18670 0.001656 0.01196 0.008114 TNFRSF1B/CXCR4/ZNF365/DAG1/ASPA/ID4/HDAC1/TLR2 8 BP GO:1901998 toxin transport 8/1096 39/18670 0.001656 0.01196 0.008114 HSPA5/SLC7A8/RAB29/ABCG1/TRIP4/DNM1/LRP5/BNIP3 8 BP GO:1905521 regulation of macrophage migration 8/1096 39/18670 0.001656 0.01196 0.008114 CCL5/RARRES2/CD200/PTK2B/MAPK3/CX3CR1/MTUS1/C3AR1 8 BP GO:0051851 modification by host of symbiont morphology or physiology 12/1096 77/18670 0.001684 0.01213 0.008224 CCL5/PC/CXCL6/HDAC1/AQP1/PF4/APOE/APCS/TFAP4/VAPA/ELANE/JUN 12 BP GO:0060038 cardiac muscle cell proliferation 11/1096 67/18670 0.001685 0.01213 0.008224 TGFBR3/TGFB2/RBP4/SMAD1/FGFR1/PIM1/CCNB1/BMPR1A/JARID2/FOXC1/RXRA 11 BP GO:0002279 mast cell activation involved in immune response 9/1096 48/18670 0.001687 0.01213 0.008224 IL4R/RAC2/STXBP1/RASGRP1/GAB2/GATA2/STXBP2/S100A13/LAT 9 BP GO:0007595 lactation 9/1096 48/18670 0.001687 0.01213 0.008224 VEGFA/HK2/XBP1/PAM/GOT2/CCND1/CDO1/HIF1A/OAS2 9 BP GO:0150063 visual system development 36/1096 366/18670 0.001715 0.01228 0.008326 TMOD1/CRYAB/TGFB2/VEGFA/CDON/EGFR/GATA3/NTRK3/SMAD3/RBP4/MYH10/MYOM2/SMARCD3/HIF1A/THY1/ATF6/BMP4/CDK4/B9D1/DIO3/HDAC1/LRP5/EFEMP1/JMJD6/NINJ1/TWIST1/LAMB2/FOXC1/OSR2/PDGFRA/IMPDH2/RING1/MYOM1/RXRA/COL4A1/JUN 36 BP GO:0034695 response to prostaglandin E 6/1096 23/18670 0.001717 0.01228 0.008326 TGFBR3/P2RY6/CCR7/ADCY6/PTGER2/SFRP1 6 BP GO:0042451 purine nucleoside biosynthetic process 6/1096 23/18670 0.001717 0.01228 0.008326 ADA/HPRT1/NME3/GUK1/IMPDH1/IMPDH2 6 BP GO:0046129 purine ribonucleoside biosynthetic process 6/1096 23/18670 0.001717 0.01228 0.008326 ADA/HPRT1/NME3/GUK1/IMPDH1/IMPDH2 6 BP GO:0072009 nephron epithelium development 15/1096 109/18670 0.001745 0.01244 0.008435 MAGI2/WWTR1/VEGFA/ADIPOQ/SIX1/GATA3/MAGED1/BMP4/PECAM1/BASP1/STAT1/CTNNBIP1/LAMB2/FOXC1/HOXA11 15 BP GO:0034404 nucleobase-containing small molecule biosynthetic process 25/1096 226/18670 0.001749 0.01244 0.008435 ZBTB20/PDE1A/ENPP1/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/DCK/GPX1/PDE9A/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/TYMP/TK2/ALDOA/NUDT3 25 BP GO:0001977 renal system process involved in regulation of blood volume 5/1096 16/18670 0.00175 0.01244 0.008435 EMP2/ADORA1/GAS6/F2R/HSD11B2 5 BP GO:0034116 positive regulation of heterotypic cell-cell adhesion 5/1096 16/18670 0.00175 0.01244 0.008435 LCK/IL1B/CD44/SKAP1/THY1 5 BP GO:0070293 renal absorption 5/1096 16/18670 0.00175 0.01244 0.008435 HBB/GSN/ADIPOQ/MAGED2/GAS6 5 BP GO:0097696 STAT cascade 20/1096 166/18670 0.001777 0.01261 0.008553 CCL5/IFNAR2/IL7R/CD40/AKR1B1/STAT4/PTPRC/HCLS1/CCR2/INPP5F/MGAT5/F2R/NMI/PECAM1/STAT1/PTPN2/FGFR3/CCL2/CRLF1/IL15 20 BP GO:0010543 regulation of platelet activation 7/1096 31/18670 0.001787 0.01262 0.008557 SERPINE2/PLEK/PDPN/PRKG1/APOE/PDGFRA/SELP 7 BP GO:0035767 endothelial cell chemotaxis 7/1096 31/18670 0.001787 0.01262 0.008557 CXCL13/SEMA5A/VEGFA/HSPB1/EGR3/FGFR1/LGMN 7 BP GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 7/1096 31/18670 0.001787 0.01262 0.008557 EGFR/CCND2/MAPRE3/CKS1B/CCND1/CCNB1/CDC6 7 BP GO:0060292 long-term synaptic depression 7/1096 31/18670 0.001787 0.01262 0.008557 STXBP1/LILRB2/PTK2B/SHANK2/ADORA1/CD38/PLK2 7 BP GO:0030879 mammary gland development 18/1096 143/18670 0.001807 0.01273 0.008632 VEGFA/GATA3/HK2/XBP1/PAM/GOT2/CCND1/AR/CDO1/CAV3/HOXA5/HIF1A/BMP4/GPX1/LRP5/IGFBP5/ARHGAP5/OAS2 18 BP GO:0044344 cellular response to fibroblast growth factor stimulus 18/1096 143/18670 0.001807 0.01273 0.008632 CCL5/CXCL13/GATA3/POSTN/SULF1/MAPK3/CXCL8/CD44/EGR3/COL1A1/FGFR1/POLR2E/POLR2I/SFRP1/FGFR3/CCL2/SPRY1/HYAL1 18 BP GO:0034103 regulation of tissue remodeling 13/1096 88/18670 0.001814 0.01276 0.008655 SPP1/TNFAIP3/ADAM8/EGFR/S1PR1/CD38/CSK/ABR/THBS4/INPP5D/TFRC/SFRP1/IL15 13 BP GO:0071385 cellular response to glucocorticoid stimulus 10/1096 58/18670 0.00185 0.013 0.008816 FOXO1/EGFR/PCK1/ICAM1/STC1/ASS1/AQP1/DDIT4/TFAP4/PCK2 10 BP GO:0006002 fructose 6-phosphate metabolic process 4/1096 10/18670 0.001864 0.013 0.008816 PFKM/GFPT1/NFE2L1/MPI 4 BP GO:0007016 cytoskeletal anchoring at plasma membrane 4/1096 10/18670 0.001864 0.013 0.008816 ANK3/FLNB/DAG1/TLN2 4 BP GO:0036500 ATF6-mediated unfolded protein response 4/1096 10/18670 0.001864 0.013 0.008816 XBP1/HSPA5/ATF6/WFS1 4 BP GO:0072015 glomerular visceral epithelial cell development 4/1096 10/18670 0.001864 0.013 0.008816 MAGI2/ADIPOQ/BMP4/LAMB2 4 BP GO:0097048 dendritic cell apoptotic process 4/1096 10/18670 0.001864 0.013 0.008816 AXL/CCR7/GAS6/CXCL12 4 BP GO:2000668 regulation of dendritic cell apoptotic process 4/1096 10/18670 0.001864 0.013 0.008816 AXL/CCR7/GAS6/CXCL12 4 BP GO:1901861 regulation of muscle tissue development 19/1096 155/18670 0.00187 0.01303 0.008837 TGFBR3/CDON/SIX1/SMAD3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/BMP4/PIM1/FZD7/CCNB1/IGFBP5/HDAC4/BMPR1A/JARID2/TWIST1 19 BP GO:0001910 regulation of leukocyte mediated cytotoxicity 12/1096 78/18670 0.001886 0.01311 0.008893 IL7R/RASGRP1/ICAM1/CD226/SH2D1A/FCGR2B/PTPRC/CRTAM/DNASE1L3/CXCL6/LAG3/VAV1 12 BP GO:0030838 positive regulation of actin filament polymerization 14/1096 99/18670 0.001887 0.01311 0.008893 CORO1A/GSN/ICAM1/BIN1/PTK2B/CCR7/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/TENM1/PFN2 14 BP GO:0019915 lipid storage 11/1096 68/18670 0.001906 0.01321 0.008962 LPL/FTO/ITGAV/ENPP1/IL1B/NFKBIA/NFKB1/ABCG1/APOE/PTPN2/IKBKE 11 BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 11/1096 68/18670 0.001906 0.01321 0.008962 VEGFA/HSPB1/ADAMTS3/MT1G/EGR3/GAS1/PTP4A3/FOXC1/NRP2/PDGFRA/FLT1 11 BP GO:0016101 diterpenoid metabolic process 15/1096 110/18670 0.001913 0.01325 0.008985 LPL/RARRES2/EGFR/ADH1B/AKR1B1/SDC1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/GPC5/DHRS3/APOE/ALDH3A2 15 BP GO:0001935 endothelial cell proliferation 22/1096 191/18670 0.001932 0.01336 0.00906 LOXL2/SEMA5A/VEGFA/AKT3/SULF1/XBP1/ITGA4/EGR3/FGFR1/GATA2/HIF1A/BMP4/STAT1/APOE/CXCL12/THBS4/AGTR1/NRP2/CCL2/NRAS/FLT1/JUN 22 BP GO:0002448 mast cell mediated immunity 9/1096 49/18670 0.001961 0.01354 0.009186 IL4R/RAC2/STXBP1/RASGRP1/GAB2/GATA2/STXBP2/S100A13/LAT 9 BP GO:0019835 cytolysis 8/1096 40/18670 0.001966 0.01354 0.009186 GZMB/GZMA/MMD/PF4/C6/LBP/C7/GZMH 8 BP GO:0071526 semaphorin-plexin signaling pathway 8/1096 40/18670 0.001966 0.01354 0.009186 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F/PLXNC1/PLXNA2/NRP2 8 BP GO:0050804 modulation of chemical synaptic transmission 41/1096 436/18670 0.002003 0.01378 0.009347 PLCB1/SERPINE2/SIPA1L1/EGR2/MECP2/STXBP1/EGFR/ADIPOQ/LILRB2/CLSTN1/PRKCB/PTK2B/CALB2/IL1B/SHANK2/ADORA1/CD38/DNM1/CX3CR1/PLK2/CCR2/AKAP9/SYNGR1/F2R/PINK1/NRGN/UNC13B/NTF3/SNCG/USP46/APOE/NGF/PCDH17/RIMS3/ABR/LGMN/CDH2/CCL2/PFN2/NPTX2/ADCY1 41 BP GO:0006094 gluconeogenesis 13/1096 89/18670 0.002013 0.01383 0.009382 FOXO1/ADIPOQ/PCK1/RBP4/SIK1/GOT2/PDK2/PC/GOT1/PTPN2/SDS/ALDOA/PCK2 13 BP GO:0006631 fatty acid metabolic process 37/1096 383/18670 0.002043 0.01402 0.009513 LPL/LTC4S/ECH1/PTGS1/HPGDS/ADIPOQ/PCK1/IL1B/GPX4/ADIPOR2/XBP1/MAPK3/CRAT/ECI1/ECHS1/RGN/PAM/TECR/PDK2/LIPC/ACADS/HADH/SLC27A2/APOC1/ALDH5A1/ACOX2/GPX1/NFE2L1/TWIST1/AOAH/ALDH3A2/PLA2G15/PTGDS/ALOX5/LYPLA1/PCK2/ETFB 37 BP GO:0034446 substrate adhesion-dependent cell spreading 14/1096 100/18670 0.002078 0.01423 0.009654 PARVA/ITGB7/ITGAV/AXL/POSTN/DOCK1/PDPN/ITGA4/KANK1/EFNA5/FZD7/GBP1/LAMB2/TYRO3 14 BP GO:0060840 artery development 14/1096 100/18670 0.002078 0.01423 0.009654 TGFB2/VEGFA/SIX1/AKT3/MYH10/BMP4/ZMIZ1/APOE/BMPR1A/FOXC1/LOXL1/NPRL3/COL3A1/SMAD6 14 BP GO:0009410 response to xenobiotic stimulus 30/1096 292/18670 0.002082 0.01424 0.00966 FOXO1/CXCR4/PTGS1/EGFR/AOC3/PCK1/ICAM1/ADA/PTK2B/CYB5R3/ASS1/PTAFR/GOT2/RGS2/HSPA5/CASQ2/BPHL/HPRT1/CDO1/AKR7A2/CCNA2/GSTA4/GPX1/NQO1/AQP1/LPO/DDIT4/TFAP4/PCK2/SLC18A2 30 BP GO:0099177 regulation of trans-synaptic signaling 41/1096 437/18670 0.002088 0.01427 0.009678 PLCB1/SERPINE2/SIPA1L1/EGR2/MECP2/STXBP1/EGFR/ADIPOQ/LILRB2/CLSTN1/PRKCB/PTK2B/CALB2/IL1B/SHANK2/ADORA1/CD38/DNM1/CX3CR1/PLK2/CCR2/AKAP9/SYNGR1/F2R/PINK1/NRGN/UNC13B/NTF3/SNCG/USP46/APOE/NGF/PCDH17/RIMS3/ABR/LGMN/CDH2/CCL2/PFN2/NPTX2/ADCY1 41 BP GO:0030193 regulation of blood coagulation 12/1096 79/18670 0.002107 0.01438 0.009752 SERPINE2/PLEK/PDPN/TFPI/F2R/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA/PRDX2/SELP 12 BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 18/1096 145/18670 0.002112 0.0144 0.009765 TNFAIP3/TNFRSF1B/IL4R/IL7R/CD226/ADA/GATA3/CD40/FCGR2B/IL1B/TP53BP1/PTPN6/IL27RA/PTPRC/CCR2/PARP3/NLRP3/TFRC 18 BP GO:0016311 dephosphorylation 44/1096 478/18670 0.002119 0.01442 0.009784 MAGI2/TGFB2/PHLPP1/LILRB2/LCK/DUSP5/PPP1R3C/PTPN13/PTPN7/PLEK/PTPN21/SMAD3/HDDC2/ADORA1/CDC25B/PTPN6/RGN/ALPL/PTPRC/CDH5/MFHAS1/DUSP14/PTPN22/INPP5F/MGAT5/PIN1/PINK1/DLC1/PPP1R2/MINPP1/NCKAP1L/PPP1R1A/DUSP2/CA3/PTPRF/INPP5D/PTP4A3/DUSP3/PPM1A/PTPN2/CAMTA1/RIMBP2/PPP3CC/PTPRE 44 BP GO:0008406 gonad development 24/1096 217/18670 0.002144 0.01458 0.009886 HOXA10/TGFB2/VEGFA/SEMA3A/ICAM1/GATA3/ATRX/NUPR1/RHOBTB3/BCL2L2/SDC1/CCND1/TNFSF10/HSPA5/INSR/AR/ERCC1/LFNG/BASP1/FOXC1/SFRP1/PDGFRA/HOXA11/INHBB 24 BP GO:0042744 hydrogen peroxide catabolic process 7/1096 32/18670 0.002173 0.01468 0.009956 HBB/PXDN/GPX3/GPX1/LPO/PRDX2/HBE1 7 BP GO:0048841 regulation of axon extension involved in axon guidance 7/1096 32/18670 0.002173 0.01468 0.009956 SEMA5A/VEGFA/SEMA3E/SEMA3A/SEMA3C/SEMA4F/CXCL12 7 BP GO:0061384 heart trabecula morphogenesis 7/1096 32/18670 0.002173 0.01468 0.009956 TGFBR3/TGFB2/S1PR1/RBP4/CAV3/UBE4B/BMPR1A 7 BP GO:0002092 positive regulation of receptor internalization 6/1096 24/18670 0.002177 0.01468 0.009956 MAGI2/ANGPT1/VEGFA/SFRP4/PLCG2/NTF3 6 BP GO:0042832 defense response to protozoan 6/1096 24/18670 0.002177 0.01468 0.009956 IL4R/CD40/BATF/IRF8/GBP2/PF4 6 BP GO:0043302 positive regulation of leukocyte degranulation 6/1096 24/18670 0.002177 0.01468 0.009956 IL4R/STXBP1/GAB2/PTAFR/GATA2/ITGB2 6 BP GO:2001026 regulation of endothelial cell chemotaxis 6/1096 24/18670 0.002177 0.01468 0.009956 CXCL13/SEMA5A/VEGFA/HSPB1/FGFR1/LGMN 6 BP GO:0051224 negative regulation of protein transport 22/1096 193/18670 0.002204 0.01484 0.01007 TNFAIP3/SRGN/ANGPT1/CD200/ADIPOQ/FCGR2B/IL1B/IL27RA/HADH/PKIG/GAS6/PTPN22/F2R/TNFRSF4/UBE2J1/GBP1/APOE/CSK/NLRP3/SFRP1/INHBB/LYPLA1 22 BP GO:0046849 bone remodeling 13/1096 90/18670 0.002229 0.01499 0.01017 SPP1/TNFAIP3/ADAM8/RAC2/EGFR/PTK2B/S1PR1/CD38/LRP5/CSK/INPP5D/TFRC/SFRP1 13 BP GO:0002062 chondrocyte differentiation 16/1096 123/18670 0.002257 0.01517 0.01029 RUNX3/CREB3L2/ZBTB16/SOX5/LOXL2/NFIB/SMAD3/SULF1/PTHLH/FGFR1/BMP4/EFEMP1/BMPR1A/FGFR3/OSR2/HOXA11 16 BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 9/1096 50/18670 0.00227 0.0152 0.01031 CXCR4/AXL/CPNE1/GAS6/CASP4/HIF1A/IRF7/AGPAT1/IKBKE 9 BP GO:0031113 regulation of microtubule polymerization 9/1096 50/18670 0.00227 0.0152 0.01031 MECP2/ARL2/PAK1/MAPRE3/CDH5/CAV3/AKAP9/CAMSAP2/STMN2 9 BP GO:0060425 lung morphogenesis 9/1096 50/18670 0.00227 0.0152 0.01031 NFIB/DAG1/MAPK3/ID1/DLG5/CTSH/HOXA5/BMP4/SPRY1 9 BP GO:0016064 immunoglobulin mediated immune response 24/1096 218/18670 0.002279 0.01523 0.01033 TRBC1/IL4R/CD226/CD40/FCGR2B/TP53BP1/PTPN6/IL27RA/BATF/PTPRC/CD27/ERCC1/PARP3/IGKC/CFI/CCR6/IGLV6-57/C6/IRF7/APCS/INPP5D/TFRC/IGLC1/C7 24 BP GO:0055123 digestive system development 18/1096 146/18670 0.002281 0.01523 0.01033 RARRES2/TGFB2/EGFR/ADA/TCF7/SMAD3/XBP1/CXCL8/ASS1/INSR/HOXA5/HIF1A/BMP4/CCNB1/SFRP1/COBL/PDGFRA/COL3A1 18 BP GO:0034440 lipid oxidation 14/1096 101/18670 0.002285 0.01525 0.01034 ECH1/ADIPOQ/ADIPOR2/CRAT/ECI1/ECHS1/ACADS/HADH/SLC27A2/ACOX2/PLA2G7/TWIST1/ALDH3A2/ETFB 14 BP GO:0001938 positive regulation of endothelial cell proliferation 15/1096 112/18670 0.002291 0.01525 0.01034 SEMA5A/VEGFA/AKT3/ITGA4/EGR3/FGFR1/GATA2/HIF1A/BMP4/CXCL12/THBS4/AGTR1/NRP2/NRAS/JUN 15 BP GO:1903510 mucopolysaccharide metabolic process 15/1096 112/18670 0.002291 0.01525 0.01034 UST/XYLT1/ANGPT1/SPOCK2/IL1B/NFKB1/CD44/B4GALT2/CHST3/PIM1/ABCC5/HEXA/UGDH/HYAL1/IL15 15 BP GO:0030890 positive regulation of B cell proliferation 8/1096 41/18670 0.002319 0.01538 0.01043 ADA/CD40/GPR183/CD38/PTPRC/TNFRSF4/NCKAP1L/TFRC 8 BP GO:0042572 retinol metabolic process 8/1096 41/18670 0.002319 0.01538 0.01043 ADH1B/AKR1B1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/DHRS3 8 BP GO:0044091 membrane biogenesis 8/1096 41/18670 0.002319 0.01538 0.01043 MAGI2/ANK3/EMP2/UGCG/RFTN1/SPTBN1/CAV3/CDH2 8 BP GO:0006109 regulation of carbohydrate metabolic process 23/1096 206/18670 0.002322 0.01538 0.01043 FOXO1/ZBTB20/P2RY6/ADIPOQ/ENPP1/PTK2B/NUPR1/PLEK/SIK1/RGN/NFKB1/PTAFR/PDK2/INSR/HIF1A/DYRK2/NFE2L1/BAD/PHLDA2/HDAC4/DDIT4/PTPN2/NUP210 23 BP GO:1900046 regulation of hemostasis 12/1096 80/18670 0.002349 0.01548 0.0105 SERPINE2/PLEK/PDPN/TFPI/F2R/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA/PRDX2/SELP 12 BP GO:1902115 regulation of organelle assembly 22/1096 194/18670 0.002352 0.01548 0.0105 DZIP1/GSN/CDK10/LCP1/NTRK3/PIP4K2B/NUPR1/GPSM2/SDC1/CNOT1/PLK2/CAV3/PINK1/G3BP1/MAP4/SPAG5/ARHGEF5/PLK1/SPICE1/NPRL3/STIL/GAP43 22 BP GO:0010744 positive regulation of macrophage derived foam cell differentiation 5/1096 17/18670 0.002361 0.01548 0.0105 LPL/NFKB1/PF4/PRKCH/AGTR1 5 BP GO:0010819 regulation of T cell chemotaxis 5/1096 17/18670 0.002361 0.01548 0.0105 CCL5/CXCL13/CCR2/CXCL10/TNFSF14 5 BP GO:0014733 regulation of skeletal muscle adaptation 5/1096 17/18670 0.002361 0.01548 0.0105 TNNT1/MYH7/TNNC1/TNNI1/IGFBP5 5 BP GO:0048532 anatomical structure arrangement 5/1096 17/18670 0.002361 0.01548 0.0105 EGR2/SEMA3A/HSPA5/BMPR1A/NRP2 5 BP GO:0061318 renal filtration cell differentiation 5/1096 17/18670 0.002361 0.01548 0.0105 MAGI2/ADIPOQ/BMP4/BASP1/LAMB2 5 BP GO:0072112 glomerular visceral epithelial cell differentiation 5/1096 17/18670 0.002361 0.01548 0.0105 MAGI2/ADIPOQ/BMP4/BASP1/LAMB2 5 BP GO:0007051 spindle organization 20/1096 170/18670 0.002362 0.01548 0.0105 MECP2/MAPRE2/EML1/ARHGEF10/KIF3B/ATRX/GPSM2/MAPRE3/PLK2/PARP3/TACC2/CCNB1/MAP4/SPAG5/TPX2/DCTN2/PLK1/SPICE1/TUBGCP4/STIL 20 BP GO:0008217 regulation of blood pressure 21/1096 182/18670 0.002366 0.01548 0.0105 CPA3/MECP2/HBB/PTGS1/ADIPOQ/NCALD/EMP2/NAMPT/POSTN/SMAD3/ADORA1/GCH1/PTAFR/AR/GAS6/ACTA2/F2R/LRP5/SLC2A5/HSD11B2/AGTR1 21 BP GO:0030041 actin filament polymerization 21/1096 182/18670 0.002366 0.01548 0.0105 TMOD1/CORO1A/GSN/ICAM1/BIN1/PTK2B/CCR7/SPTBN1/HCLS1/CAPG/KANK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/PSTPIP1/COBL/TENM1/PFN2 21 BP GO:0042267 natural killer cell mediated cytotoxicity 10/1096 60/18670 0.002405 0.01571 0.01066 CORO1A/GZMB/RASGRP1/CD226/SH2D1A/PTPN6/RAB27A/CRTAM/LAG3/VAV1 10 BP GO:0060395 SMAD protein signal transduction 11/1096 70/18670 0.002418 0.01578 0.0107 MAGI2/WWTR1/TGFB2/SMAD3/SPTBN1/SMAD1/BMP4/GDF10/BMPR1A/INHBB/JUN 11 BP GO:0071375 cellular response to peptide hormone stimulus 32/1096 321/18670 0.002438 0.01589 0.01078 FOXO1/LPL/RARRES2/SH2B2/ADIPOQ/PCK1/ENPP1/PRKCB/IL1B/PAK1/ADCY9/XBP1/ASS1/NFKB1/PDK2/INSR/ADCY6/KANK1/GOT1/CCNA2/CDK4/TBC1D4/STAT1/CSK/AGTR1/PTPN2/INHBB/ATP6V0D1/PTPRE/PCK2/CDC6/ADCY1 32 BP GO:0008637 apoptotic mitochondrial changes 16/1096 124/18670 0.002454 0.01596 0.01083 GZMB/HK2/NOL3/TNFSF10/PINK1/GPX1/ATP2A1/PLAUR/ZNF205/BAD/PIM2/MLLT11/SLC25A4/BNIP3/PPP3CC/JUN 16 BP GO:0051209 release of sequestered calcium ion into cytosol 16/1096 124/18670 0.002454 0.01596 0.01083 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0071236 cellular response to antibiotic 18/1096 147/18670 0.00246 0.01598 0.01084 FOXO1/TNFAIP3/AXL/PCGF2/DAXX/ID3/HSPA5/TRAP1/ADCY6/PINK1/EFNA5/NQO1/MAPK7/AQP1/MAPK13/BNIP3/CCL7/ADCY1 18 BP GO:1901992 positive regulation of mitotic cell cycle phase transition 13/1096 91/18670 0.002464 0.01599 0.01084 PLCB1/MECP2/EGFR/CDK10/CCND2/CDC25B/CCND1/SMARCD3/CDK4/CCNB1/CUL4A/HYAL1/CDC6 13 BP GO:0048640 negative regulation of developmental growth 15/1096 113/18670 0.002502 0.01622 0.011 SPP1/SEMA5A/SEMA3E/SEMA3A/PAK1/RBP4/RGS2/CAV3/SEMA3C/SEMA4F/BMP4/JARID2/LGMN/SFRP1/FGFR3 15 BP GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 14/1096 102/18670 0.002509 0.01623 0.01101 TNFAIP3/EGFR/CCND2/MAPRE3/CKS1B/CCND1/CDKN2C/CCNA2/CDK4/CCNB1/TFAP4/PLK1/CDC6/CCNB2 14 BP GO:2000379 positive regulation of reactive oxygen species metabolic process 14/1096 102/18670 0.002509 0.01623 0.01101 HBB/EGFR/ICAM1/PTK2B/IL1B/SMAD3/RGN/ASS1/RAB27A/INSR/ZNF205/HDAC4/AGTR1/ITGB2 14 BP GO:0002712 regulation of B cell mediated immunity 9/1096 51/18670 0.002615 0.01681 0.0114 CD226/CD40/FCGR2B/TP53BP1/PTPN6/IL27RA/PTPRC/PARP3/TFRC 9 BP GO:0002889 regulation of immunoglobulin mediated immune response 9/1096 51/18670 0.002615 0.01681 0.0114 CD226/CD40/FCGR2B/TP53BP1/PTPN6/IL27RA/PTPRC/PARP3/TFRC 9 BP GO:0045599 negative regulation of fat cell differentiation 9/1096 51/18670 0.002615 0.01681 0.0114 FOXO1/WWTR1/ADIPOQ/ENPP1/GATA3/SMAD3/TRIB2/GATA2/ID4 9 BP GO:0002756 MyD88-independent toll-like receptor signaling pathway 7/1096 33/18670 0.00262 0.01681 0.0114 BIRC3/LY96/CD14/IRF7/TRAF3/IKBKG/IKBKE 7 BP GO:0010092 specification of animal organ identity 7/1096 33/18670 0.00262 0.01681 0.0114 SIX1/AR/FGFR1/SMARCD3/BMP4/HOXA11/SPRY1 7 BP GO:0061036 positive regulation of cartilage development 7/1096 33/18670 0.00262 0.01681 0.0114 ZBTB16/SOX5/LOXL2/SMAD3/SMAD1/BMP4/HOXA11 7 BP GO:0070232 regulation of T cell apoptotic process 7/1096 33/18670 0.00262 0.01681 0.0114 CCL5/ADAM8/IL7R/ADA/CD27/HIF1A/BMP4 7 BP GO:0035148 tube formation 18/1096 148/18670 0.002651 0.01699 0.01152 TGFB2/VEGFA/SIX1/NFIB/GATA3/FZD2/TGM2/RALA/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 18 BP GO:0045787 positive regulation of cell cycle 37/1096 389/18670 0.002665 0.01706 0.01157 PLCB1/MECP2/TGFA/TGFB2/EGFR/SVIL/CDK10/KIF3B/ATRX/IL1B/GPSM2/BTG2/CCND2/CDC25B/BTC/MAPRE3/CKS1B/CCND1/CNOT1/INSR/FGFR1/PLK2/PAF1/SMARCD3/CDK4/LFNG/CCNB1/LRP5/SPAG5/CNOT4/CARM1/TFAP4/LGMN/DUSP3/CUL4A/HYAL1/CDC6 37 BP GO:0032874 positive regulation of stress-activated MAPK cascade 20/1096 172/18670 0.002711 0.01718 0.01165 PLCB1/TGFB2/VEGFA/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAP3K4/MFHAS1/CD27/SASH1/MAP4K1/FZD7/ARHGEF5 20 BP GO:0002639 positive regulation of immunoglobulin production 8/1096 42/18670 0.002719 0.01718 0.01165 IL4R/CD40/TP53BP1/RBP4/XBP1/PTPRC/TNFRSF4/TFRC 8 BP GO:0033003 regulation of mast cell activation 8/1096 42/18670 0.002719 0.01718 0.01165 IL4R/RAC2/STXBP1/CD226/GAB2/PLSCR1/GATA2/STXBP2 8 BP GO:0001562 response to protozoan 6/1096 25/18670 0.002724 0.01718 0.01165 IL4R/CD40/BATF/IRF8/GBP2/PF4 6 BP GO:0002053 positive regulation of mesenchymal cell proliferation 6/1096 25/18670 0.002724 0.01718 0.01165 VEGFA/SIX1/FGFR1/LRP5/STAT1/BMPR1A 6 BP GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 6/1096 25/18670 0.002724 0.01718 0.01165 EMP2/ADORA1/GAS6/F2R/HSD11B2/AGTR1 6 BP GO:0019430 removal of superoxide radicals 6/1096 25/18670 0.002724 0.01718 0.01165 GCH1/RGN/FBLN5/NQO1/FANCC/PRDX2 6 BP GO:0061217 regulation of mesonephros development 6/1096 25/18670 0.002724 0.01718 0.01165 VEGFA/SIX1/GATA3/MAGED1/BMP4/BASP1 6 BP GO:0072012 glomerulus vasculature development 6/1096 25/18670 0.002724 0.01718 0.01165 ANGPT1/ACTA2/BMP4/PECAM1/ANGPT2/PDGFRA 6 BP GO:2000482 regulation of interleukin-8 secretion 6/1096 25/18670 0.002724 0.01718 0.01165 FCN1/CD2/CD14/PTPN22/F2R/TLR2 6 BP GO:0019724 B cell mediated immunity 24/1096 221/18670 0.002727 0.01718 0.01165 TRBC1/IL4R/CD226/CD40/FCGR2B/TP53BP1/PTPN6/IL27RA/BATF/PTPRC/CD27/ERCC1/PARP3/IGKC/CFI/CCR6/IGLV6-57/C6/IRF7/APCS/INPP5D/TFRC/IGLC1/C7 24 BP GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 10/1096 61/18670 0.002728 0.01718 0.01165 TNFAIP3/ADIPOQ/BIRC3/CPNE1/NOL3/TRAF1/GAS6/CASP4/PTPN2/IKBKG 10 BP GO:0030888 regulation of B cell proliferation 10/1096 61/18670 0.002728 0.01718 0.01165 ADA/CD40/FCGR2B/GPR183/CD38/PTPRC/TNFRSF4/NCKAP1L/INPP5D/TFRC 10 BP GO:0071384 cellular response to corticosteroid stimulus 10/1096 61/18670 0.002728 0.01718 0.01165 FOXO1/EGFR/PCK1/ICAM1/STC1/ASS1/AQP1/DDIT4/TFAP4/PCK2 10 BP GO:0090303 positive regulation of wound healing 10/1096 61/18670 0.002728 0.01718 0.01165 CXCR4/HBEGF/PLEK/XBP1/PDPN/KANK1/F2R/SERPINE1/PRDX2/SELP 10 BP GO:0003093 regulation of glomerular filtration 4/1096 11/18670 0.002793 0.01728 0.01172 EMP2/ADORA1/GAS6/F2R 4 BP GO:0006558 L-phenylalanine metabolic process 4/1096 11/18670 0.002793 0.01728 0.01172 FAH/HPD/PCBD1/QDPR 4 BP GO:0006559 L-phenylalanine catabolic process 4/1096 11/18670 0.002793 0.01728 0.01172 FAH/HPD/PCBD1/QDPR 4 BP GO:0014883 transition between fast and slow fiber 4/1096 11/18670 0.002793 0.01728 0.01172 TNNT1/MYH7/TNNC1/TNNI1 4 BP GO:0019852 L-ascorbic acid metabolic process 4/1096 11/18670 0.002793 0.01728 0.01172 SLC2A3/RGN/SLC23A2/CYB5R3 4 BP GO:0021561 facial nerve development 4/1096 11/18670 0.002793 0.01728 0.01172 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0021610 facial nerve morphogenesis 4/1096 11/18670 0.002793 0.01728 0.01172 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0033632 regulation of cell-cell adhesion mediated by integrin 4/1096 11/18670 0.002793 0.01728 0.01172 CCL5/CXCL13/ADA/SKAP1 4 BP GO:0060272 embryonic skeletal joint morphogenesis 4/1096 11/18670 0.002793 0.01728 0.01172 BMP4/OSR2/HOXA11/HYAL1 4 BP GO:0061307 cardiac neural crest cell differentiation involved in heart development 4/1096 11/18670 0.002793 0.01728 0.01172 MAPK3/SEMA3C/BMP4/TWIST1 4 BP GO:0061308 cardiac neural crest cell development involved in heart development 4/1096 11/18670 0.002793 0.01728 0.01172 MAPK3/SEMA3C/BMP4/TWIST1 4 BP GO:0072310 glomerular epithelial cell development 4/1096 11/18670 0.002793 0.01728 0.01172 MAGI2/ADIPOQ/BMP4/LAMB2 4 BP GO:0072683 T cell extravasation 4/1096 11/18670 0.002793 0.01728 0.01172 ICAM1/IL27RA/CCR2/CCL2 4 BP GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 4/1096 11/18670 0.002793 0.01728 0.01172 FAH/HPD/PCBD1/QDPR 4 BP GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 4/1096 11/18670 0.002793 0.01728 0.01172 FAH/HPD/PCBD1/QDPR 4 BP GO:1902563 regulation of neutrophil activation 4/1096 11/18670 0.002793 0.01728 0.01172 FCGR2B/PTAFR/ABR/ITGB2 4 BP GO:0090068 positive regulation of cell cycle process 30/1096 298/18670 0.002828 0.01748 0.01185 PLCB1/MECP2/TGFA/EGFR/SVIL/CDK10/KIF3B/ATRX/IL1B/GPSM2/BTG2/CCND2/CDC25B/BTC/CCND1/CNOT1/INSR/FGFR1/PLK2/PAF1/SMARCD3/CDK4/CCNB1/LRP5/SPAG5/CNOT4/CARM1/CUL4A/HYAL1/CDC6 30 BP GO:1904950 negative regulation of establishment of protein localization 22/1096 197/18670 0.002847 0.01757 0.01192 TNFAIP3/SRGN/ANGPT1/CD200/ADIPOQ/FCGR2B/IL1B/IL27RA/HADH/PKIG/GAS6/PTPN22/F2R/TNFRSF4/UBE2J1/GBP1/APOE/CSK/NLRP3/SFRP1/INHBB/LYPLA1 22 BP GO:0051283 negative regulation of sequestering of calcium ion 16/1096 126/18670 0.00289 0.01782 0.01208 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 24/1096 222/18670 0.002893 0.01782 0.01208 FCN1/CXCR4/CCL5/GSN/ITGAV/SLPI/CXCL8/MID2/PLSCR1/ISG20/PC/CXCL6/LAMP3/POLR2E/HDAC1/BAD/STAT1/APOE/APCS/POLR2I/TFAP4/VAPA/JUN/SUPT5H 24 BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 20/1096 173/18670 0.002901 0.01785 0.0121 PLCB1/TGFB2/VEGFA/RASGRP1/SEMA3A/IL1RN/PTK2B/FCGR2B/IL1B/SLAMF1/CCR7/PAK1/DAXX/MAP3K4/MFHAS1/CD27/SASH1/MAP4K1/FZD7/ARHGEF5 20 BP GO:0007589 body fluid secretion 13/1096 93/18670 0.002995 0.0184 0.01248 VEGFA/ADA/HK2/XBP1/ADORA1/PAM/GOT2/CCND1/CDO1/HIF1A/AQP1/OAS2/CHRM3 13 BP GO:0016447 somatic recombination of immunoglobulin gene segments 9/1096 52/18670 0.003001 0.01842 0.0125 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0007389 pattern specification process 41/1096 446/18670 0.003018 0.01851 0.01255 ZBTB16/EGR2/HOXA10/CDON/SEMA3A/SIX1/PCGF2/KIF3B/STC1/MEOX1/SMAD3/ZIC1/BTG2/ASPH/SMAD1/AR/FGFR1/SEMA3C/SMARCD3/HOXA5/HIF1A/AP1B1/BMP4/ETS2/LFNG/LRP5/BASP1/CTNNBIP1/BMPR1A/PLXNA2/SIM2/FOXC1/SFRP1/NRP2/COBL/HOXA11/RING1/SPRY1/SMAD6/STIL/TCF15 41 BP GO:0006635 fatty acid beta-oxidation 11/1096 72/18670 0.003036 0.0186 0.01262 ECH1/ADIPOQ/CRAT/ECI1/ECHS1/ACADS/HADH/SLC27A2/ACOX2/TWIST1/ETFB 11 BP GO:0045137 development of primary sexual characteristics 24/1096 223/18670 0.003066 0.01876 0.01273 HOXA10/TGFB2/VEGFA/SEMA3A/ICAM1/GATA3/ATRX/NUPR1/RHOBTB3/BCL2L2/SDC1/CCND1/TNFSF10/HSPA5/INSR/AR/ERCC1/LFNG/BASP1/FOXC1/SFRP1/PDGFRA/HOXA11/INHBB 24 BP GO:0070507 regulation of microtubule cytoskeleton organization 21/1096 186/18670 0.003076 0.0188 0.01275 MECP2/ARL2/EPHA3/MAPRE2/GPSM2/PAK1/MAPRE3/CDH5/PLK2/CAV3/AKAP9/CAMSAP2/EFNA5/PARP3/STMN2/SPAG5/TPX2/PLK1/SPICE1/STIL/ATF5 21 BP GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 10/1096 62/18670 0.003085 0.0188 0.01275 CD40/TCF7/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 10 BP GO:0016444 somatic cell DNA recombination 10/1096 62/18670 0.003085 0.0188 0.01275 CD40/TCF7/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 10 BP GO:0046635 positive regulation of alpha-beta T cell activation 10/1096 62/18670 0.003085 0.0188 0.01275 RUNX3/IL4R/ZBTB16/ADA/PTPRC/CD83/CCR2/NCKAP1L/CD86/NLRP3 10 BP GO:0030833 regulation of actin filament polymerization 19/1096 162/18670 0.003101 0.01882 0.01277 TMOD1/CORO1A/GSN/ICAM1/BIN1/PTK2B/CCR7/SPTBN1/HCLS1/CAPG/KANK1/GMFG/NCKAP1/NCKAP1L/RHOBTB1/CTTN/ARPC3/TENM1/PFN2 19 BP GO:0034375 high-density lipoprotein particle remodeling 5/1096 18/18670 0.003112 0.01882 0.01277 LPL/LIPC/ABCG1/APOC1/APOE 5 BP GO:0035994 response to muscle stretch 5/1096 18/18670 0.003112 0.01882 0.01277 NFKBIA/NFKB1/CAV3/TTN/JUN 5 BP GO:0048339 paraxial mesoderm development 5/1096 18/18670 0.003112 0.01882 0.01277 SMAD3/FGFR1/BMPR1A/FOXC1/TCF15 5 BP GO:0060749 mammary gland alveolus development 5/1096 18/18670 0.003112 0.01882 0.01277 VEGFA/CCND1/AR/HOXA5/HIF1A 5 BP GO:0061377 mammary gland lobule development 5/1096 18/18670 0.003112 0.01882 0.01277 VEGFA/CCND1/AR/HOXA5/HIF1A 5 BP GO:0072311 glomerular epithelial cell differentiation 5/1096 18/18670 0.003112 0.01882 0.01277 MAGI2/ADIPOQ/BMP4/BASP1/LAMB2 5 BP GO:0003382 epithelial cell morphogenesis 7/1096 34/18670 0.003135 0.01894 0.01285 FLNB/STC1/ID1/AR/PECAM1/SPINT2/ST14 7 BP GO:1903531 negative regulation of secretion by cell 23/1096 211/18670 0.003151 0.01902 0.0129 TNFAIP3/TNFRSF1B/SRGN/ANGPT1/CD200/ADIPOQ/FCGR2B/IL1B/ADORA1/IL27RA/NMB/HADH/GAS6/CCR2/PTPN22/F2R/TNFRSF4/GBP1/APOE/ABR/NLRP3/SFRP1/INHBB 23 BP GO:0045429 positive regulation of nitric oxide biosynthetic process 8/1096 43/18670 0.003172 0.01912 0.01297 HBB/ICAM1/PTK2B/IL1B/SMAD3/ASS1/INSR/ITGB2 8 BP GO:0071560 cellular response to transforming growth factor beta stimulus 26/1096 249/18670 0.003203 0.01929 0.01308 TGFBR3/SOX5/TGFB2/POSTN/SMAD3/HSPA5/CDH5/SMAD1/ID1/COL1A1/CX3CR1/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/MAPK7/HTRA1/GDF10/BMPR1A/SFRP1/PPM1A/COL3A1/SMAD6/ADAMTSL2/JUN 26 BP GO:0007009 plasma membrane organization 14/1096 105/18670 0.003292 0.0198 0.01343 CXCR4/TGFB2/GSN/ANK3/FNBP1L/NDRG1/UGCG/BIN1/SPTBN1/MYH10/PTPRC/PLSCR1/AR/CAV3 14 BP GO:0099173 postsynapse organization 19/1096 163/18670 0.003323 0.01997 0.01354 MAGI2/SIPA1L1/LILRB2/NDRG1/NTRK3/ZNF365/FCGR2B/ACTN1/SHANK2/MYH10/INSR/APOE/GLRB/CTTN/PDLIM5/LGMN/CDH2/NRP2/GAP43 19 BP GO:0010758 regulation of macrophage chemotaxis 6/1096 26/18670 0.003368 0.02013 0.01366 CCL5/RARRES2/PTK2B/MAPK3/MTUS1/C3AR1 6 BP GO:0030194 positive regulation of blood coagulation 6/1096 26/18670 0.003368 0.02013 0.01366 PLEK/PDPN/F2R/SERPINE1/PRDX2/SELP 6 BP GO:0060037 pharyngeal system development 6/1096 26/18670 0.003368 0.02013 0.01366 TGFB2/SIX1/GATA3/BMP4/BMPR1A/PLXNA2 6 BP GO:0060740 prostate gland epithelium morphogenesis 6/1096 26/18670 0.003368 0.02013 0.01366 SULF1/AR/ID4/BMP4/SFRP1/RXRA 6 BP GO:1900048 positive regulation of hemostasis 6/1096 26/18670 0.003368 0.02013 0.01366 PLEK/PDPN/F2R/SERPINE1/PRDX2/SELP 6 BP GO:0010595 positive regulation of endothelial cell migration 16/1096 128/18670 0.003389 0.02016 0.01367 ANGPT1/SEMA5A/VEGFA/AKT3/GATA3/PTK2B/CD40/HSPB1/FGFR1/SASH1/PLK2/GATA2/HIF1A/BMP4/LGMN/NRP2 16 BP GO:0051282 regulation of sequestering of calcium ion 16/1096 128/18670 0.003389 0.02016 0.01367 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0031100 animal organ regeneration 11/1096 73/18670 0.00339 0.02016 0.01367 TGFBR3/EGFR/AXL/LCP1/RGN/CCND1/GAS6/CCNA2/CDK4/CXCL12/ANGPT2 11 BP GO:0045685 regulation of glial cell differentiation 11/1096 73/18670 0.00339 0.02016 0.01367 TNFRSF1B/SERPINE2/CXCR4/NTRK3/BIN1/ZNF365/DAG1/ASPA/ID4/HDAC1/TLR2 11 BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 11/1096 73/18670 0.00339 0.02016 0.01367 CXCL13/CCL13/CXCL8/S100A9/CXCL1/CXCL6/PF4/CXCL3/CXCL10/GNLY/ELANE 11 BP GO:0045214 sarcomere organization 9/1096 53/18670 0.00343 0.02038 0.01382 TNNT1/LDB3/CASQ2/CSRP1/MYOM2/CAV3/TTN/MYBPC2/MYOM1 9 BP GO:0034599 cellular response to oxidative stress 30/1096 302/18670 0.003444 0.02044 0.01386 FOXO1/TNFAIP3/EGFR/AXL/GPX3/PCGF2/MAPK3/HSPB1/GCH1/RGN/FBLN5/NOL3/PDK2/TRAP1/HIF1A/ALDH3B1/PINK1/CCNA2/GPX1/NQO1/MAPK7/NFE2L1/AQP1/FANCC/MAPK13/NCF2/PDGFRA/BNIP3/PRDX2/JUN 30 BP GO:0031345 negative regulation of cell projection organization 21/1096 188/18670 0.003493 0.02071 0.01405 SPP1/SEMA5A/SEMA3E/SEMA3A/CDK10/ZNF365/CD38/RAB29/ID1/ADCY6/PLK2/INPP5F/KANK1/SEMA3C/THY1/SEMA4F/APOE/STMN2/MAP4/CARM1/PFN2 21 BP GO:0002761 regulation of myeloid leukocyte differentiation 15/1096 117/18670 0.003512 0.02079 0.0141 ADIPOQ/TCTA/LILRB4/HCLS1/GATA2/PF4/CTNNBIP1/LILRB3/IRF7/APCS/INPP5D/SFRP1/PTPN2/CUL4A/JUN 15 BP GO:0051607 defense response to virus 25/1096 238/18670 0.003514 0.02079 0.0141 TNFAIP3/IFNAR2/IRF1/AIM2/BIRC3/CD40/IL1B/PTPRC/PLSCR1/ISG20/PCBP2/MX2/HTRA1/STAT1/GBP1/CXCL10/G3BP1/IRF7/DDIT4/NLRP3/TRAF3/IL2RA/BNIP3/OAS2/IL15 25 BP GO:0001936 regulation of endothelial cell proliferation 20/1096 176/18670 0.003538 0.02091 0.01418 SEMA5A/VEGFA/AKT3/SULF1/ITGA4/EGR3/FGFR1/GATA2/HIF1A/BMP4/STAT1/APOE/CXCL12/THBS4/AGTR1/NRP2/CCL2/NRAS/FLT1/JUN 20 BP GO:0016202 regulation of striated muscle tissue development 18/1096 152/18670 0.003543 0.02092 0.01419 TGFBR3/CDON/SIX1/SMAD3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/BMP4/PIM1/FZD7/CCNB1/HDAC4/BMPR1A/JARID2/TWIST1 18 BP GO:0050818 regulation of coagulation 12/1096 84/18670 0.003556 0.02095 0.01421 SERPINE2/PLEK/PDPN/TFPI/F2R/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA/PRDX2/SELP 12 BP GO:0060420 regulation of heart growth 12/1096 84/18670 0.003556 0.02095 0.01421 TGFBR3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/PIM1/CCNB1/BASP1/BMPR1A/JARID2 12 BP GO:0021537 telencephalon development 26/1096 251/18670 0.003567 0.02099 0.01424 PLCB1/EZH1/CXCR4/CDON/EGFR/SEMA3A/NFIB/BTG2/MYH10/HPRT1/HIF1A/NRGN/ID4/BMP4/TACC2/HDAC1/AQP1/BAD/BCL2A1/CXCL12/CDH2/NRP2/GNG12/BNIP3/COL3A1/ATF5 26 BP GO:0009896 positive regulation of catabolic process 39/1096 423/18670 0.003574 0.02101 0.01425 FOXO1/TNFAIP3/TNFRSF1B/ZBTB20/FTO/ADAM8/PIP4K2B/PTK2B/NUPR1/IL1B/HK2/MAPK3/ADORA1/NEDD4L/BTG2/RGN/RNF144A/CTSC/CNOT1/TRIB2/MID2/INSR/PLK2/CAV3/HIF1A/PINK1/BAD/PIM2/AREL1/APOE/KAT5/TWIST1/PLK1/BNIP3/USP5/IKBKG/HERPUD1/PTTG1IP/SUPT5H 39 BP GO:1901989 positive regulation of cell cycle phase transition 14/1096 106/18670 0.003593 0.02108 0.0143 PLCB1/MECP2/EGFR/CDK10/CCND2/CDC25B/CCND1/PAF1/SMARCD3/CDK4/CCNB1/CUL4A/HYAL1/CDC6 14 BP GO:1904029 regulation of cyclin-dependent protein kinase activity 14/1096 106/18670 0.003593 0.02108 0.0143 TNFAIP3/EGFR/CCND2/MAPRE3/CKS1B/CCND1/CDKN2C/CCNA2/CDK4/CCNB1/TFAP4/PLK1/CDC6/CCNB2 14 BP GO:0002702 positive regulation of production of molecular mediator of immune response 13/1096 95/18670 0.003615 0.0211 0.01431 IL4R/CD226/GATA3/CD40/IL1B/TP53BP1/RBP4/XBP1/MAPK3/PTPRC/TNFRSF4/NLRP3/TFRC 13 BP GO:0042102 positive regulation of T cell proliferation 13/1096 95/18670 0.003615 0.0211 0.01431 CCL5/CORO1A/LILRB2/IL1B/PTPRC/CCR2/IGFBP2/NCKAP1L/HLA-DMB/CD86/TFRC/IL2RA/IL15 13 BP GO:0042116 macrophage activation 13/1096 95/18670 0.003615 0.0211 0.01431 IL4R/CD200/FCGR2B/NAMPT/CTSC/PTPRC/MFHAS1/CST7/JMJD6/TLR2/LBP/ITGB2/JUN 13 BP GO:0060337 type I interferon signaling pathway 13/1096 95/18670 0.003615 0.0211 0.01431 IFNAR2/IRF1/PTPN6/MYD88/ISG20/IRF8/GBP2/MX2/STAT1/IRF7/PTPN2/OAS2/IKBKE 13 BP GO:0071357 cellular response to type I interferon 13/1096 95/18670 0.003615 0.0211 0.01431 IFNAR2/IRF1/PTPN6/MYD88/ISG20/IRF8/GBP2/MX2/STAT1/IRF7/PTPN2/OAS2/IKBKE 13 BP GO:0060249 anatomical structure homeostasis 40/1096 437/18670 0.003628 0.02115 0.01435 SPP1/TNFAIP3/ADAM8/RAC2/CORO1A/WWTR1/VEGFA/EGFR/AKT3/PTK2B/CALB2/ZNF365/ATRX/AKR1B1/PFKM/S1PR1/RBP4/MAPK3/ADORA1/HSPB1/MAP3K4/CD38/GATA2/CTSH/CCR2/ERCC1/CAV3/HIF1A/F2R/PARP3/IGKC/USP7/CSK/INPP5D/FOXC1/TFRC/PRIM2/TFIP11/TYRO3/ALDOA 40 BP GO:0050853 B cell receptor signaling pathway 16/1096 129/18670 0.003664 0.02132 0.01446 TRBC1/ITK/LCK/PRKCB/FCGR2B/RFTN1/PTPN6/CD38/PTPRC/PLCG2/PTPN22/IGKC/NCKAP1L/PRKCH/LPXN/IGLC1 16 BP GO:0031346 positive regulation of cell projection organization 36/1096 383/18670 0.003664 0.02132 0.01446 CREB3L2/CXCR4/MAGI2/RAC2/DZIP1/SEMA5A/VEGFA/EPHA3/FNBP1L/NTRK3/PTK2B/CUX1/SHANK2/AUTS2/CCR7/PAK1/NEDD4L/S100A9/RALA/RGS2/HSPA5/FGFR1/DLG5/SYT17/RAPGEF1/EFNA5/NCKAP1/APOE/NGF/PLXNC1/STMN2/HDAC4/PLXNA2/CXCL12/COBL/TENM1 36 BP GO:0038084 vascular endothelial growth factor signaling pathway 8/1096 44/18670 0.003682 0.02136 0.01449 VEGFA/HSPB1/ADAMTS3/PTP4A3/FOXC1/NRP2/PDGFRA/FLT1 8 BP GO:0046688 response to copper ion 8/1096 44/18670 0.003682 0.02136 0.01449 LOXL2/ICAM1/DAXX/PAM/MT1G/S100A13/NFE2L1/AQP1 8 BP GO:1904407 positive regulation of nitric oxide metabolic process 8/1096 44/18670 0.003682 0.02136 0.01449 HBB/ICAM1/PTK2B/IL1B/SMAD3/ASS1/INSR/ITGB2 8 BP GO:0042092 type 2 immune response 7/1096 35/18670 0.003724 0.02151 0.01459 IL4R/GATA3/IL27RA/BATF/CCR2/CD86/NLRP3 7 BP GO:0098801 regulation of renal system process 7/1096 35/18670 0.003724 0.02151 0.01459 ADIPOQ/EMP2/STC1/ADORA1/GAS6/F2R/AGTR1 7 BP GO:1904031 positive regulation of cyclin-dependent protein kinase activity 7/1096 35/18670 0.003724 0.02151 0.01459 EGFR/CCND2/MAPRE3/CKS1B/CCND1/CCNB1/CDC6 7 BP GO:1905332 positive regulation of morphogenesis of an epithelium 7/1096 35/18670 0.003724 0.02151 0.01459 VEGFA/SIX1/GATA3/ITGAX/MAGED1/AR/BMP4 7 BP GO:0050709 negative regulation of protein secretion 17/1096 141/18670 0.003757 0.02169 0.01471 TNFAIP3/SRGN/ANGPT1/CD200/FCGR2B/IL1B/IL27RA/HADH/GAS6/PTPN22/F2R/TNFRSF4/GBP1/APOE/NLRP3/SFRP1/INHBB 17 BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 11/1096 74/18670 0.003775 0.02172 0.01473 RUNX3/IL4R/RELB/GATA3/GPR183/BATF/CD83/NCKAP1L/SATB1/CD86/NLRP3 11 BP GO:0050710 negative regulation of cytokine secretion 11/1096 74/18670 0.003775 0.02172 0.01473 TNFAIP3/SRGN/ANGPT1/CD200/FCGR2B/IL27RA/GAS6/PTPN22/TNFRSF4/GBP1/NLRP3 11 BP GO:1903036 positive regulation of response to wounding 11/1096 74/18670 0.003775 0.02172 0.01473 CXCR4/HBEGF/NTRK3/PLEK/XBP1/PDPN/KANK1/F2R/SERPINE1/PRDX2/SELP 11 BP GO:0001894 tissue homeostasis 24/1096 227/18670 0.003852 0.02213 0.01501 SPP1/TNFAIP3/ADAM8/RAC2/CORO1A/WWTR1/VEGFA/EGFR/AKT3/PTK2B/AKR1B1/S1PR1/RBP4/HSPB1/CD38/GATA2/CTSH/CCR2/F2R/IGKC/CSK/INPP5D/FOXC1/TFRC 24 BP GO:0010721 negative regulation of cell development 33/1096 344/18670 0.003854 0.02213 0.01501 SPP1/SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/ZNF365/IL1B/POSTN/PAK1/ID3/CD38/RGS2/RAB29/PTHLH/ID1/ADCY6/PLK2/INPP5F/KANK1/CAV3/SEMA3C/THY1/SEMA4F/ID4/EFNA5/DIO3/GBP1/APOE/STMN2/BMPR1A/CARM1/COL3A1 33 BP GO:0030199 collagen fibril organization 9/1096 54/18670 0.003907 0.02235 0.01516 DDR2/LOXL2/TGFB2/PXDN/ADAMTS2/ADAMTS3/COL1A1/FOXC1/COL3A1 9 BP GO:0043392 negative regulation of DNA binding 9/1096 54/18670 0.003907 0.02235 0.01516 CPNE1/ID3/NFKBIA/GZMA/ID1/ID4/CTNNBIP1/TFAP4/JUN 9 BP GO:0061005 cell differentiation involved in kidney development 9/1096 54/18670 0.003907 0.02235 0.01516 MAGI2/WWTR1/ADIPOQ/GATA3/ACTA2/BMP4/BASP1/STAT1/LAMB2 9 BP GO:0045600 positive regulation of fat cell differentiation 10/1096 64/18670 0.003911 0.02235 0.01516 ZBTB16/LPL/RARRES2/WIF1/ADIRF/XBP1/LRP5/LMO3/CARM1/SFRP1 10 BP GO:0060135 maternal process involved in female pregnancy 10/1096 64/18670 0.003911 0.02235 0.01516 SPP1/STC1/AKR1B1/MAPK3/PAM/RGS2/LDOC1/AR/ANGPT2/RXRA 10 BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 14/1096 107/18670 0.003916 0.02236 0.01516 NDRG1/ATRX/BTG2/BATF/CNOT1/CD44/PLK2/CCNB1/KAT5/TWIST1/CNOT4/CARM1/TFAP4/PTTG1IP 14 BP GO:0030516 regulation of axon extension 13/1096 96/18670 0.003962 0.02257 0.01531 SEMA5A/VEGFA/SEMA3E/SEMA3A/NTRK3/PAK1/OLFM1/SEMA3C/SEMA4F/APOE/CTTN/CXCL12/DPYSL2 13 BP GO:0032388 positive regulation of intracellular transport 23/1096 215/18670 0.003983 0.02257 0.01531 IL4R/RAC2/HUWE1/STXBP1/ANK3/TCF7L2/IL1B/SMAD3/ZIC1/PAK1/GAB2/RAB29/TM9SF4/HCLS1/GAS6/GATA2/PINK1/UNC13B/ATP2A1/SPAG5/ITGB2/PPM1A/TENM1 23 BP GO:0002674 negative regulation of acute inflammatory response 4/1096 12/18670 0.003997 0.02257 0.01531 FCGR2B/ADORA1/NLRP3/APCS 4 BP GO:0007077 mitotic nuclear envelope disassembly 4/1096 12/18670 0.003997 0.02257 0.01531 PRKCB/CCNB1/PLK1/CCNB2 4 BP GO:0019336 phenol-containing compound catabolic process 4/1096 12/18670 0.003997 0.02257 0.01531 MAOA/FAH/MOXD1/DIO3 4 BP GO:0035437 maintenance of protein localization in endoplasmic reticulum 4/1096 12/18670 0.003997 0.02257 0.01531 HSPA5/GPAA1/KDELR3/KDELR1 4 BP GO:0042659 regulation of cell fate specification 4/1096 12/18670 0.003997 0.02257 0.01531 AR/FGFR1/FZD7/BMPR1A 4 BP GO:0043922 negative regulation by host of viral transcription 4/1096 12/18670 0.003997 0.02257 0.01531 CCL5/HDAC1/TFAP4/JUN 4 BP GO:0070243 regulation of thymocyte apoptotic process 4/1096 12/18670 0.003997 0.02257 0.01531 ADAM8/ADA/HIF1A/BMP4 4 BP GO:0071888 macrophage apoptotic process 4/1096 12/18670 0.003997 0.02257 0.01531 CCL5/CCR5/CTSL/IRF7 4 BP GO:1900165 negative regulation of interleukin-6 secretion 4/1096 12/18670 0.003997 0.02257 0.01531 CD200/IL27RA/GAS6/PTPN22 4 BP GO:0001710 mesodermal cell fate commitment 5/1096 19/18670 0.004022 0.02266 0.01537 SMAD1/FGFR1/BMP4/BMPR1A/HOXA11 5 BP GO:0045076 regulation of interleukin-2 biosynthetic process 5/1096 19/18670 0.004022 0.02266 0.01537 IL1B/PTPRC/LAG3/CD86/GLMN 5 BP GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 6/1096 27/18670 0.004118 0.02307 0.01565 MECP2/CDC25B/CCND1/SMARCD3/CDK4/CCNB1 6 BP GO:0050820 positive regulation of coagulation 6/1096 27/18670 0.004118 0.02307 0.01565 PLEK/PDPN/F2R/SERPINE1/PRDX2/SELP 6 BP GO:0061437 renal system vasculature development 6/1096 27/18670 0.004118 0.02307 0.01565 ANGPT1/ACTA2/BMP4/PECAM1/ANGPT2/PDGFRA 6 BP GO:0061440 kidney vasculature development 6/1096 27/18670 0.004118 0.02307 0.01565 ANGPT1/ACTA2/BMP4/PECAM1/ANGPT2/PDGFRA 6 BP GO:0071450 cellular response to oxygen radical 6/1096 27/18670 0.004118 0.02307 0.01565 GCH1/RGN/FBLN5/NQO1/FANCC/PRDX2 6 BP GO:0071451 cellular response to superoxide 6/1096 27/18670 0.004118 0.02307 0.01565 GCH1/RGN/FBLN5/NQO1/FANCC/PRDX2 6 BP GO:0042593 glucose homeostasis 25/1096 241/18670 0.004137 0.02315 0.0157 FOXO1/ZBTB20/ADIPOQ/PCK1/ICAM1/TCF7L2/ADIPOR2/HK2/RBP4/XBP1/NMB/PDK2/INSR/OXCT1/GAS6/CAV3/HIF1A/EFNA5/UNC13B/LRP5/IGFBP5/BAD/PTPN2/WFS1/PCK2 25 BP GO:0032869 cellular response to insulin stimulus 23/1096 216/18670 0.004218 0.02358 0.01599 FOXO1/LPL/RARRES2/SH2B2/ADIPOQ/PCK1/ENPP1/PRKCB/IL1B/PAK1/XBP1/PDK2/INSR/KANK1/GOT1/CDK4/TBC1D4/STAT1/PTPN2/INHBB/ATP6V0D1/PTPRE/PCK2 23 BP GO:1900271 regulation of long-term synaptic potentiation 8/1096 45/18670 0.004252 0.02375 0.01611 LILRB2/CALB2/ADORA1/CX3CR1/NRGN/APOE/LGMN/ADCY1 8 BP GO:0051208 sequestering of calcium ion 16/1096 131/18670 0.004268 0.02379 0.01614 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 16/1096 131/18670 0.004268 0.02379 0.01614 MECP2/EML1/ARHGEF10/KIF3B/GPSM2/PLK2/PARP3/TACC2/CCNB1/MAP4/TPX2/DCTN2/PLK1/SPICE1/SPRY1/STIL 16 BP GO:0030101 natural killer cell activation 12/1096 86/18670 0.004324 0.02402 0.01629 CORO1A/AXL/RASGRP1/CD2/RAB27A/PTPRC/GAS6/PTPN22/ELF4/ITGB2/TYRO3/IL15 12 BP GO:0007044 cell-substrate junction assembly 13/1096 97/18670 0.004336 0.02402 0.01629 VEGFA/EPHA3/PTK2B/ACTN1/SMAD3/DST/THY1/DLC1/ITGA5/EFNA5/CTTN/SFRP1/DUSP3 13 BP GO:0014020 primary neural tube formation 13/1096 97/18670 0.004336 0.02402 0.01629 TGFB2/FZD2/RALA/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 13 BP GO:0043255 regulation of carbohydrate biosynthetic process 13/1096 97/18670 0.004336 0.02402 0.01629 FOXO1/P2RY6/ADIPOQ/ENPP1/PTK2B/PLEK/SIK1/NFKB1/PTAFR/PDK2/INSR/DYRK2/PTPN2 13 BP GO:0048709 oligodendrocyte differentiation 13/1096 97/18670 0.004336 0.02402 0.01629 TNFRSF1B/CXCR4/GSN/ZNF365/DAG1/CDKN2C/ASPA/ID4/TSPAN2/HDAC1/TLR2/CSK/BNIP3 13 BP GO:0035296 regulation of tube diameter 17/1096 143/18670 0.004343 0.02402 0.01629 HBB/EGFR/ICAM1/ADORA1/GCH1/PTAFR/CD38/RGS2/ADCY6/ACTA2/F2R/GPX1/PRKG1/APOE/AGTR1/FOXC1/CHRM3 17 BP GO:0050880 regulation of blood vessel size 17/1096 143/18670 0.004343 0.02402 0.01629 HBB/EGFR/ICAM1/ADORA1/GCH1/PTAFR/CD38/RGS2/ADCY6/ACTA2/F2R/GPX1/PRKG1/APOE/AGTR1/FOXC1/CHRM3 17 BP GO:0097746 regulation of blood vessel diameter 17/1096 143/18670 0.004343 0.02402 0.01629 HBB/EGFR/ICAM1/ADORA1/GCH1/PTAFR/CD38/RGS2/ADCY6/ACTA2/F2R/GPX1/PRKG1/APOE/AGTR1/FOXC1/CHRM3 17 BP GO:0033500 carbohydrate homeostasis 25/1096 242/18670 0.004364 0.02409 0.01634 FOXO1/ZBTB20/ADIPOQ/PCK1/ICAM1/TCF7L2/ADIPOR2/HK2/RBP4/XBP1/NMB/PDK2/INSR/OXCT1/GAS6/CAV3/HIF1A/EFNA5/UNC13B/LRP5/IGFBP5/BAD/PTPN2/WFS1/PCK2 25 BP GO:0010977 negative regulation of neuron projection development 18/1096 155/18670 0.004365 0.02409 0.01634 SPP1/SEMA5A/SEMA3E/SEMA3A/ZNF365/CD38/RAB29/ID1/ADCY6/PLK2/INPP5F/KANK1/SEMA3C/THY1/SEMA4F/APOE/STMN2/CARM1 18 BP GO:0014823 response to activity 10/1096 65/18670 0.004385 0.02418 0.0164 CXCR4/ADIPOQ/PCK1/POSTN/GOT2/HADH/OXCT1/HIF1A/ANGPT2/UQCRC1 10 BP GO:0006721 terpenoid metabolic process 15/1096 120/18670 0.004471 0.02463 0.01671 LPL/RARRES2/EGFR/ADH1B/AKR1B1/SDC1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/GPC5/DHRS3/APOE/ALDH3A2 15 BP GO:0009743 response to carbohydrate 24/1096 230/18670 0.004546 0.02502 0.01697 ZBTB20/LPL/ADIPOQ/PCK1/ICAM1/PRKCB/PTK2B/TCF7L2/IL1B/NAMPT/XBP1/OXCT1/GAS6/ERCC1/HIF1A/GOT1/EFNA5/UNC13B/LRP5/SLC2A5/BAD/MAPK13/ANGPT2/PCK2 24 BP GO:0070613 regulation of protein processing 20/1096 180/18670 0.004566 0.02508 0.01701 SERPINE2/ADAM8/GSN/CFB/BIRC3/IL1B/NOL3/CFP/CST7/GAS1/IGKC/CFI/PHB/SERPINE1/IGLV6-57/C6/IGLC1/C7/C3AR1/TNP2 20 BP GO:0071466 cellular response to xenobiotic stimulus 20/1096 180/18670 0.004566 0.02508 0.01701 FOXO1/PTGS1/EGFR/AOC3/PCK1/ICAM1/CYB5R3/ASS1/CASQ2/BPHL/CDO1/AKR7A2/CCNA2/GSTA4/NQO1/AQP1/LPO/DDIT4/TFAP4/PCK2 20 BP GO:0048844 artery morphogenesis 11/1096 76/18670 0.004651 0.02553 0.01731 TGFB2/VEGFA/SIX1/AKT3/BMP4/ZMIZ1/APOE/BMPR1A/FOXC1/NPRL3/COL3A1 11 BP GO:0035150 regulation of tube size 17/1096 144/18670 0.004662 0.02554 0.01732 HBB/EGFR/ICAM1/ADORA1/GCH1/PTAFR/CD38/RGS2/ADCY6/ACTA2/F2R/GPX1/PRKG1/APOE/AGTR1/FOXC1/CHRM3 17 BP GO:0007259 JAK-STAT cascade 18/1096 156/18670 0.004671 0.02554 0.01732 CCL5/IFNAR2/CD40/AKR1B1/STAT4/PTPRC/HCLS1/CCR2/INPP5F/F2R/NMI/PECAM1/STAT1/PTPN2/FGFR3/CCL2/CRLF1/IL15 18 BP GO:0030856 regulation of epithelial cell differentiation 18/1096 156/18670 0.004671 0.02554 0.01732 WWTR1/VEGFA/ADIPOQ/GATA3/IL1B/SFRP4/CCND1/CDH5/CTSL/ID1/BMP4/BAD/STAT1/SERPINE1/PRKCH/KIAA1109/MAFF/FOXC1 18 BP GO:0048634 regulation of muscle organ development 18/1096 156/18670 0.004671 0.02554 0.01732 TGFBR3/CDON/SIX1/SMAD3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/BMP4/PIM1/FZD7/CCNB1/HDAC4/BMPR1A/JARID2/TWIST1 18 BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 13/1096 98/18670 0.004738 0.02583 0.01752 KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/DCTN2/LGMN 13 BP GO:0031341 regulation of cell killing 13/1096 98/18670 0.004738 0.02583 0.01752 IL7R/RASGRP1/ICAM1/CD226/SH2D1A/FCGR2B/PTPRC/CRTAM/DNASE1L3/CXCL6/LAG3/BAD/VAV1 13 BP GO:0050848 regulation of calcium-mediated signaling 13/1096 98/18670 0.004738 0.02583 0.01752 P2RY6/ADA/PTK2B/PLEK/PLN/RGN/CASQ2/PDK2/DYRK2/HOMER3/MAPK7/GBP1/CAMTA1 13 BP GO:0001704 formation of primary germ layer 15/1096 121/18670 0.004834 0.02633 0.01786 ITGAV/SMAD3/ITGA4/SMAD1/FGFR1/PAF1/BMP4/ITGA5/ETS2/FZD7/BMPR1A/FOXC1/ITGB2/HOXA11/MMP15 15 BP GO:0006984 ER-nucleus signaling pathway 8/1096 46/18670 0.004888 0.02654 0.018 XBP1/CXCL8/HSPA5/ATF6/PTPN2/CCL2/WFS1/HERPUD1 8 BP GO:0010883 regulation of lipid storage 8/1096 46/18670 0.004888 0.02654 0.018 LPL/FTO/ITGAV/NFKBIA/NFKB1/ABCG1/PTPN2/IKBKE 8 BP GO:0044003 modification by symbiont of host morphology or physiology 8/1096 46/18670 0.004888 0.02654 0.018 ITGAV/NTRK3/DAG1/SMAD3/INSR/BAD/RXRA/VAPA 8 BP GO:0045428 regulation of nitric oxide biosynthetic process 10/1096 66/18670 0.004902 0.0266 0.01804 HBB/ICAM1/PTK2B/IL1B/SMAD3/RGN/ASS1/INSR/CX3CR1/ITGB2 10 BP GO:0030307 positive regulation of cell growth 19/1096 169/18670 0.004944 0.0268 0.01818 CXCR4/SEMA5A/TGFB2/VEGFA/EGFR/HBEGF/NTRK3/PTK2B/PAK1/NEDD4L/S100A9/CD38/SYT17/PIN1/EFNA5/NGF/CXCL12/SFRP1/HYAL1 19 BP GO:0010818 T cell chemotaxis 6/1096 28/18670 0.004986 0.02689 0.01824 CCL5/CXCL13/GPR183/CCR2/CXCL10/TNFSF14 6 BP GO:0035456 response to interferon-beta 6/1096 28/18670 0.004986 0.02689 0.01824 IFNAR2/IRF1/AIM2/PLSCR1/STAT1/IKBKE 6 BP GO:0060512 prostate gland morphogenesis 6/1096 28/18670 0.004986 0.02689 0.01824 SULF1/AR/ID4/BMP4/SFRP1/RXRA 6 BP GO:0085029 extracellular matrix assembly 6/1096 28/18670 0.004986 0.02689 0.01824 MFAP4/SMAD3/FBLN5/MYH11/GAS6/EFEMP2 6 BP GO:0009952 anterior/posterior pattern specification 23/1096 219/18670 0.004991 0.02689 0.01824 ZBTB16/HOXA10/CDON/PCGF2/MEOX1/SMAD3/BTG2/SEMA3C/HOXA5/BMP4/ETS2/LFNG/LRP5/BASP1/CTNNBIP1/BMPR1A/PLXNA2/FOXC1/SFRP1/COBL/HOXA11/RING1/TCF15 23 BP GO:0001764 neuron migration 18/1096 157/18670 0.004995 0.02689 0.01824 CXCR4/VEGFA/AXL/SEMA3A/GATA3/NTRK3/DCLK1/AUTS2/MYH10/FGFR1/GAS6/GATA2/PRKG1/DDIT4/CXCL12/TWIST1/NRP2/COL3A1 18 BP GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response 9/1096 56/18670 0.005013 0.02689 0.01824 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0031295 T cell costimulation 9/1096 56/18670 0.005013 0.02689 0.01824 LCK/CCR7/PAK1/PTPN6/PAK2/CD86/CSK/VAV1/TNFSF14 9 BP GO:0050879 multicellular organismal movement 9/1096 56/18670 0.005013 0.02689 0.01824 SYNM/EEF2/TNNT1/TNNC2/MB/MYH7/TNNC1/CAV3/ATP2A1 9 BP GO:0050881 musculoskeletal movement 9/1096 56/18670 0.005013 0.02689 0.01824 SYNM/EEF2/TNNT1/TNNC2/MB/MYH7/TNNC1/CAV3/ATP2A1 9 BP GO:0090183 regulation of kidney development 9/1096 56/18670 0.005013 0.02689 0.01824 WWTR1/VEGFA/ADIPOQ/SIX1/GATA3/MAGED1/BMP4/BASP1/STAT1 9 BP GO:0002374 cytokine secretion involved in immune response 5/1096 20/18670 0.005107 0.02727 0.01849 TNFRSF1B/ANGPT1/MAPK3/TLR2/NLRP3 5 BP GO:0003215 cardiac right ventricle morphogenesis 5/1096 20/18670 0.005107 0.02727 0.01849 TGFB2/GATA3/SEMA3C/SMARCD3/BMPR1A 5 BP GO:0033005 positive regulation of mast cell activation 5/1096 20/18670 0.005107 0.02727 0.01849 IL4R/STXBP1/CD226/GAB2/GATA2 5 BP GO:0034143 regulation of toll-like receptor 4 signaling pathway 5/1096 20/18670 0.005107 0.02727 0.01849 TNFAIP3/MFHAS1/LILRA2/PTPN22/LBP 5 BP GO:0045655 regulation of monocyte differentiation 5/1096 20/18670 0.005107 0.02727 0.01849 CTNNBIP1/IRF7/APCS/INPP5D/JUN 5 BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 11/1096 77/18670 0.005146 0.02741 0.01859 EGFR/TNFRSF10B/IL1B/NR3C2/CHI3L1/CD14/CD27/SASH1/TLR2/PTP4A3/TNFSF14 11 BP GO:0010614 negative regulation of cardiac muscle hypertrophy 7/1096 37/18670 0.005148 0.02741 0.01859 FOXO1/TNFRSF1B/SMAD3/PAK1/RGS2/CAV3/JARID2 7 BP GO:0033280 response to vitamin D 7/1096 37/18670 0.005148 0.02741 0.01859 SPP1/STC1/ALPL/PIM1/CXCL10/SFRP1/IL15 7 BP GO:1903317 regulation of protein maturation 20/1096 182/18670 0.005167 0.02741 0.01859 SERPINE2/ADAM8/GSN/CFB/BIRC3/IL1B/NOL3/CFP/CST7/GAS1/IGKC/CFI/PHB/SERPINE1/IGLV6-57/C6/IGLC1/C7/C3AR1/TNP2 20 BP GO:0019395 fatty acid oxidation 13/1096 99/18670 0.005169 0.02741 0.01859 ECH1/ADIPOQ/ADIPOR2/CRAT/ECI1/ECHS1/ACADS/HADH/SLC27A2/ACOX2/TWIST1/ALDH3A2/ETFB 13 BP GO:0034340 response to type I interferon 13/1096 99/18670 0.005169 0.02741 0.01859 IFNAR2/IRF1/PTPN6/MYD88/ISG20/IRF8/GBP2/MX2/STAT1/IRF7/PTPN2/OAS2/IKBKE 13 BP GO:0048525 negative regulation of viral process 13/1096 99/18670 0.005169 0.02741 0.01859 FCN1/CCL5/GSN/SLPI/MID2/PLSCR1/ISG20/HDAC1/STAT1/APCS/TFAP4/VAPA/JUN 13 BP GO:0009791 post-embryonic development 12/1096 88/18670 0.005219 0.02766 0.01876 MECP2/VEGFA/GATA3/ATRX/MYL2/ALDH5A1/ERCC1/SEMA3C/BMP4/EFEMP1/ATF5/SLC18A2 12 BP GO:0002920 regulation of humoral immune response 16/1096 134/18670 0.005326 0.02817 0.0191 CXCL13/CFB/FCGR2B/IL1B/CCR7/PTPN6/PTPRC/CFP/IGKC/CFI/PHB/IGLV6-57/C6/IGLC1/C7/C3AR1 16 BP GO:0048565 digestive tract development 16/1096 134/18670 0.005326 0.02817 0.0191 RARRES2/TGFB2/EGFR/ADA/TCF7/SMAD3/CXCL8/ASS1/HOXA5/HIF1A/BMP4/CCNB1/SFRP1/COBL/PDGFRA/COL3A1 16 BP GO:0042108 positive regulation of cytokine biosynthetic process 10/1096 67/18670 0.005467 0.02876 0.0195 IRF1/IL1B/HSPB1/PTAFR/PTPRC/CCR2/CD86/LBP/ELANE/GLMN 10 BP GO:0010745 negative regulation of macrophage derived foam cell differentiation 4/1096 13/18670 0.005508 0.02876 0.0195 ITGAV/ADIPOQ/NFKBIA/ABCG1 4 BP GO:0010872 regulation of cholesterol esterification 4/1096 13/18670 0.005508 0.02876 0.0195 ABCG1/APOC1/APOE/AGTR1 4 BP GO:0014745 negative regulation of muscle adaptation 4/1096 13/18670 0.005508 0.02876 0.0195 FOXO1/SMAD3/NOL3/IGFBP5 4 BP GO:0032823 regulation of natural killer cell differentiation 4/1096 13/18670 0.005508 0.02876 0.0195 AXL/RASGRP1/GAS6/IL15 4 BP GO:0033127 regulation of histone phosphorylation 4/1096 13/18670 0.005508 0.02876 0.0195 IL1B/MAPK3/CCNB1/TWIST1 4 BP GO:0033623 regulation of integrin activation 4/1096 13/18670 0.005508 0.02876 0.0195 CXCL13/PLEK/SKAP1/SELP 4 BP GO:0045059 positive thymic T cell selection 4/1096 13/18670 0.005508 0.02876 0.0195 CD3D/PTPRC/CD3G/PTPN2 4 BP GO:0045086 positive regulation of interleukin-2 biosynthetic process 4/1096 13/18670 0.005508 0.02876 0.0195 IL1B/PTPRC/CD86/GLMN 4 BP GO:0045779 negative regulation of bone resorption 4/1096 13/18670 0.005508 0.02876 0.0195 TNFAIP3/CD38/CSK/INPP5D 4 BP GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 4/1096 13/18670 0.005508 0.02876 0.0195 NTRK3/NTF3/SPRY1/CYFIP2 4 BP GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/1096 13/18670 0.005508 0.02876 0.0195 POSTN/KANK1/EFNA5/GBP1 4 BP GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 4/1096 13/18670 0.005508 0.02876 0.0195 SEMA3A/PLXNC1/PLXNA2/NRP2 4 BP GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 4/1096 13/18670 0.005508 0.02876 0.0195 NFIB/LILRB4/BMP4/HDAC4 4 BP GO:0046394 carboxylic acid biosynthetic process 41/1096 462/18670 0.005556 0.02898 0.01966 UST/ZBTB20/LPL/LTC4S/PTGS1/HPGDS/ADIPOQ/CH25H/NUPR1/IL1B/PFKM/GPX4/ADIPOR2/HK2/XBP1/GCH1/RGN/ASS1/TECR/NFKB1/GOT2/LIPC/INSR/SLC27A2/BCAT1/CDO1/APOC1/HIF1A/ASPA/ACOX2/GOT1/ABCC5/HDAC4/DDIT4/SDS/NUP210/PTGDS/ALOX5/UGDH/ALDOA/HYAL1 41 BP GO:0006953 acute-phase response 8/1096 47/18670 0.005594 0.02905 0.0197 SERPINA1/IL1B/ASS1/PLSCR1/F8/LBP/APCS/SAA4 8 BP GO:0035722 interleukin-12-mediated signaling pathway 8/1096 47/18670 0.005594 0.02905 0.0197 PLCB1/LCP1/HNRNPDL/STAT4/RALA/PAK2/LMNB1/RPLP0 8 BP GO:0045058 T cell selection 8/1096 47/18670 0.005594 0.02905 0.0197 CD3D/GATA3/CCR7/BATF/PTPRC/CD3G/PTPN2/IL15 8 BP GO:0046638 positive regulation of alpha-beta T cell differentiation 8/1096 47/18670 0.005594 0.02905 0.0197 RUNX3/IL4R/ZBTB16/ADA/CD83/NCKAP1L/CD86/NLRP3 8 BP GO:1900744 regulation of p38MAPK cascade 8/1096 47/18670 0.005594 0.02905 0.0197 VEGFA/PHLPP1/IL1B/MAP3K4/MFHAS1/SASH1/PTPN22/CAV3 8 BP GO:0055024 regulation of cardiac muscle tissue development 13/1096 100/18670 0.00563 0.02921 0.01981 TGFBR3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/BMP4/PIM1/FZD7/CCNB1/BMPR1A/JARID2 13 BP GO:0001755 neural crest cell migration 9/1096 57/18670 0.00565 0.02926 0.01985 SEMA5A/SEMA3E/SEMA3A/SEMA3C/HIF1A/SEMA4F/BMP4/TWIST1/NRP2 9 BP GO:0031294 lymphocyte costimulation 9/1096 57/18670 0.00565 0.02926 0.01985 LCK/CCR7/PAK1/PTPN6/PAK2/CD86/CSK/VAV1/TNFSF14 9 BP GO:0055021 regulation of cardiac muscle tissue growth 11/1096 78/18670 0.005681 0.02939 0.01994 TGFBR3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/PIM1/CCNB1/BMPR1A/JARID2 11 BP GO:0002673 regulation of acute inflammatory response 18/1096 159/18670 0.005698 0.02945 0.01998 ADAM8/CFB/FCGR2B/IL1B/CCR7/ADORA1/DNASE1L3/CFP/IGKC/CFI/PHB/IGLV6-57/C6/NLRP3/APCS/IGLC1/C7/C3AR1 18 BP GO:0032602 chemokine production 12/1096 89/18670 0.005719 0.02952 0.02002 IL4R/LPL/ADIPOQ/IL1B/POSTN/S100A9/CXCL6/HIF1A/TLR2/LBP/TWIST1/ELANE 12 BP GO:0001889 liver development 16/1096 135/18670 0.005722 0.02952 0.02002 TNFAIP3/TGFBR3/EGFR/PCK1/ADA/SMAD3/XBP1/RGN/ASS1/CCND1/SEC63/QDPR/JARID2/COBL/PCK2/JUN 16 BP GO:0061351 neural precursor cell proliferation 17/1096 147/18670 0.005739 0.02958 0.02007 FOXO1/SOX5/VEGFA/CDON/EML1/BTG2/CX3CR1/FGFR1/GATA2/RAPGEF1/SMARCD3/HIF1A/ID4/RERE/CDH2/SPINT2/ATF5 17 BP GO:0016053 organic acid biosynthetic process 41/1096 463/18670 0.005762 0.02968 0.02013 UST/ZBTB20/LPL/LTC4S/PTGS1/HPGDS/ADIPOQ/CH25H/NUPR1/IL1B/PFKM/GPX4/ADIPOR2/HK2/XBP1/GCH1/RGN/ASS1/TECR/NFKB1/GOT2/LIPC/INSR/SLC27A2/BCAT1/CDO1/APOC1/HIF1A/ASPA/ACOX2/GOT1/ABCC5/HDAC4/DDIT4/SDS/NUP210/PTGDS/ALOX5/UGDH/ALDOA/HYAL1 41 BP GO:0048639 positive regulation of developmental growth 20/1096 184/18670 0.00583 0.02997 0.02033 PLCB1/TGFBR3/CXCR4/SEMA5A/VEGFA/NTRK3/PAK1/NEDD4L/INSR/FGFR1/SYT17/PIN1/PIM1/EFNA5/DIO3/CCNB1/BASP1/NGF/BMPR1A/CXCL12 20 BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 20/1096 184/18670 0.00583 0.02997 0.02033 PLCB1/EGFR/CDK10/BTG2/CCND2/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/PLK2/CDK4/CCNB1/CNOT4/CARM1/CCL2/FHL1/CUL4A/HYAL1/CDC6 20 BP GO:0000303 response to superoxide 6/1096 29/18670 0.00598 0.03058 0.02074 GCH1/RGN/FBLN5/NQO1/FANCC/PRDX2 6 BP GO:0003016 respiratory system process 6/1096 29/18670 0.00598 0.03058 0.02074 FTO/MECP2/ADORA1/TNNC1/HOXA5/TCF15 6 BP GO:0006929 substrate-dependent cell migration 6/1096 29/18670 0.00598 0.03058 0.02074 ADAM8/SEMA3A/MYH10/PTPRC/CTTN/NRP2 6 BP GO:0010954 positive regulation of protein processing 6/1096 29/18670 0.00598 0.03058 0.02074 ADAM8/GSN/IL1B/PHB/C6/TNP2 6 BP GO:0060441 epithelial tube branching involved in lung morphogenesis 6/1096 29/18670 0.00598 0.03058 0.02074 DAG1/DLG5/CTSH/HOXA5/BMP4/SPRY1 6 BP GO:0070229 negative regulation of lymphocyte apoptotic process 6/1096 29/18670 0.00598 0.03058 0.02074 CCL5/IL7R/ADA/CD27/HIF1A/BMP4 6 BP GO:0048246 macrophage chemotaxis 7/1096 38/18670 0.005998 0.03061 0.02076 CCL5/RARRES2/PTK2B/MAPK3/MTUS1/C3AR1/CCL2 7 BP GO:1900077 negative regulation of cellular response to insulin stimulus 7/1096 38/18670 0.005998 0.03061 0.02076 LPL/ENPP1/PRKCB/IL1B/KANK1/PTPN2/PTPRE 7 BP GO:0001838 embryonic epithelial tube formation 15/1096 124/18670 0.00607 0.0309 0.02096 TGFB2/SIX1/GATA3/FZD2/RALA/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 15 BP GO:0030203 glycosaminoglycan metabolic process 18/1096 160/18670 0.006079 0.0309 0.02096 UST/XYLT1/ANGPT1/SPOCK2/IL1B/SDC1/NFKB1/CD44/B4GALT2/CHST3/PIM1/ABCC5/GPC5/HEXA/FOXC1/UGDH/HYAL1/IL15 18 BP GO:1903305 regulation of regulated secretory pathway 18/1096 160/18670 0.006079 0.0309 0.02096 IL4R/RAC2/STXBP1/PRKCB/FCGR2B/GAB2/RAB27A/PTAFR/GATA2/STXBP2/SYT17/CCR2/UNC13B/RIMS3/ABR/ITGB2/PFN2/ADCY1 18 BP GO:0010812 negative regulation of cell-substrate adhesion 10/1096 68/18670 0.006081 0.0309 0.02096 SEMA3E/POSTN/COL1A1/KANK1/DLC1/EFNA5/FZD7/GBP1/SERPINE1/ANGPT2 10 BP GO:0071242 cellular response to ammonium ion 10/1096 68/18670 0.006081 0.0309 0.02096 PLCB1/GABRB1/MAPK3/ASS1/GNA11/PTAFR/ID1/CCNA2/CASP7/CHRM3 10 BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 13/1096 101/18670 0.006124 0.03106 0.02107 KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/DCTN2/LGMN 13 BP GO:0032649 regulation of interferon-gamma production 13/1096 101/18670 0.006124 0.03106 0.02107 AXL/RASGRP1/CD226/GATA3/IL1B/CD2/CCR7/IL27RA/CD14/GAS6/CCR2/PTPN22/IRF8 13 BP GO:0002792 negative regulation of peptide secretion 17/1096 148/18670 0.00614 0.03111 0.0211 TNFAIP3/SRGN/ANGPT1/CD200/FCGR2B/IL1B/IL27RA/HADH/GAS6/PTPN22/F2R/TNFRSF4/GBP1/APOE/NLRP3/SFRP1/INHBB 17 BP GO:0001843 neural tube closure 12/1096 90/18670 0.006256 0.03161 0.02144 TGFB2/FZD2/RALA/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 12 BP GO:0034333 adherens junction assembly 12/1096 90/18670 0.006256 0.03161 0.02144 VEGFA/EPHA3/PTK2B/ACTN1/SMAD3/DLG5/THY1/DLC1/EFNA5/CTTN/SFRP1/DUSP3 12 BP GO:0045778 positive regulation of ossification 12/1096 90/18670 0.006256 0.03161 0.02144 ZBTB16/DDR2/TGFB2/ZHX3/SMAD3/NELL1/SMAD1/BMP4/LRP5/CTNNBIP1/BMPR1A/OSR2 12 BP GO:0021675 nerve development 11/1096 79/18670 0.006259 0.03161 0.02144 SERPINE2/EGR2/SEMA3A/SIX1/DAG1/SULF1/ITGA4/UNC13B/NTF3/NGF/NRP2 11 BP GO:0006949 syncytium formation 9/1096 58/18670 0.006348 0.03183 0.02159 IL4R/CDON/TCTA/CD53/ERCC1/CAV3/ADAM12/CXCL10/TNFSF14 9 BP GO:0032722 positive regulation of chemokine production 9/1096 58/18670 0.006348 0.03183 0.02159 IL4R/LPL/ADIPOQ/IL1B/POSTN/HIF1A/TLR2/LBP/TWIST1 9 BP GO:0061900 glial cell activation 9/1096 58/18670 0.006348 0.03183 0.02159 EGFR/IL1B/NAMPT/CTSC/PTPRC/CST7/TLR2/ITGB2/JUN 9 BP GO:0001659 temperature homeostasis 19/1096 173/18670 0.006351 0.03183 0.02159 NOVA1/FOXO1/IL4R/CXCR4/FTO/FABP4/VEGFA/ADIPOQ/THRA/IL1B/ADIPOR2/ADORA1/HADH/ID1/UCP2/CCR2/G0S2/GPX1/IL15 19 BP GO:0007528 neuromuscular junction development 8/1096 48/18670 0.006375 0.03183 0.02159 ANK3/SIX1/SHANK2/PDZRN3/F2R/UNC13B/LAMB2/COL4A1 8 BP GO:0090199 regulation of release of cytochrome c from mitochondria 8/1096 48/18670 0.006375 0.03183 0.02159 NOL3/TNFSF10/PINK1/GPX1/PLAUR/BAD/MLLT11/BNIP3 8 BP GO:0002438 acute inflammatory response to antigenic stimulus 5/1096 21/18670 0.006384 0.03183 0.02159 ICAM1/GATA3/FCGR2B/CCR7/ELANE 5 BP GO:0003094 glomerular filtration 5/1096 21/18670 0.006384 0.03183 0.02159 EMP2/SULF1/ADORA1/GAS6/F2R 5 BP GO:0032332 positive regulation of chondrocyte differentiation 5/1096 21/18670 0.006384 0.03183 0.02159 ZBTB16/SOX5/LOXL2/SMAD3/HOXA11 5 BP GO:0036499 PERK-mediated unfolded protein response 5/1096 21/18670 0.006384 0.03183 0.02159 CXCL8/HSPA5/PTPN2/CCL2/HERPUD1 5 BP GO:0061213 positive regulation of mesonephros development 5/1096 21/18670 0.006384 0.03183 0.02159 VEGFA/SIX1/GATA3/MAGED1/BASP1 5 BP GO:2000114 regulation of establishment of cell polarity 5/1096 21/18670 0.006384 0.03183 0.02159 GSN/GATA3/PTK2B/CDH5/KANK1 5 BP GO:2000738 positive regulation of stem cell differentiation 5/1096 21/18670 0.006384 0.03183 0.02159 SOX5/TGFB2/SEMA3C/BMP4/FOXC1 5 BP GO:0032609 interferon-gamma production 14/1096 113/18670 0.006388 0.03183 0.02159 AXL/RASGRP1/ITK/CD226/GATA3/IL1B/CD2/CCR7/IL27RA/CD14/GAS6/CCR2/PTPN22/IRF8 14 BP GO:0046620 regulation of organ growth 14/1096 113/18670 0.006388 0.03183 0.02159 TGFBR3/PAK1/RBP4/RGS2/FGFR1/CAV3/PIN1/PIM1/CCNB1/BASP1/BMPR1A/JARID2/FOXC1/CARM1 14 BP GO:0002367 cytokine production involved in immune response 13/1096 102/18670 0.006652 0.03309 0.02245 TNFRSF1B/ANGPT1/TGFB2/CD226/GATA3/IL1B/MAPK3/TRIL/GAS6/CCR2/TLR2/KDELR1/NLRP3 13 BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 13/1096 102/18670 0.006652 0.03309 0.02245 KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/DCTN2/LGMN 13 BP GO:0070227 lymphocyte apoptotic process 10/1096 69/18670 0.006747 0.03353 0.02274 CCL5/ADAM8/IL7R/ADA/CD3G/CD27/HIF1A/BMP4/KDELR1/IL2RA 10 BP GO:0045666 positive regulation of neuron differentiation 34/1096 371/18670 0.006821 0.03387 0.02297 CREB3L2/CXCR4/MAGI2/SEMA5A/VEGFA/CDON/EPHA3/NTRK3/PTK2B/CPNE1/CUX1/SHANK2/PAK1/NEDD4L/S100A9/RGS2/HSPA5/CRX/FGFR1/DLG5/TIMP2/GATA2/SYT17/RAPGEF1/BMP4/EFNA5/MMD/APOE/NGF/PLXNC1/STMN2/PLXNA2/CXCL12/COBL 34 BP GO:0060333 interferon-gamma-mediated signaling pathway 12/1096 91/18670 0.006832 0.03387 0.02297 ICAM1/IRF1/PTAFR/CD44/NMI/IRF8/GBP2/STAT1/GBP1/IRF7/PTPN2/OAS2 12 BP GO:0060606 tube closure 12/1096 91/18670 0.006832 0.03387 0.02297 TGFB2/FZD2/RALA/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 12 BP GO:0022617 extracellular matrix disassembly 11/1096 80/18670 0.006883 0.03409 0.02312 DDR2/ADAM8/LCP1/CD44/PDPN/CTSL/TIMP2/HTRA1/CAPNS1/MMP15/ELANE 11 BP GO:0051048 negative regulation of secretion 24/1096 238/18670 0.006923 0.03426 0.02324 TNFAIP3/TNFRSF1B/SRGN/ANGPT1/CD200/ADIPOQ/ADA/FCGR2B/IL1B/ADORA1/IL27RA/NMB/HADH/GAS6/CCR2/PTPN22/F2R/TNFRSF4/GBP1/APOE/ABR/NLRP3/SFRP1/INHBB 24 BP GO:0019048 modulation by virus of host morphology or physiology 7/1096 39/18670 0.006947 0.03429 0.02326 NTRK3/DAG1/SMAD3/INSR/BAD/RXRA/VAPA 7 BP GO:0072595 maintenance of protein localization in organelle 7/1096 39/18670 0.006947 0.03429 0.02326 ARL2/HK2/HSPA5/GPAA1/PINK1/KDELR3/KDELR1 7 BP GO:2000826 regulation of heart morphogenesis 7/1096 39/18670 0.006947 0.03429 0.02326 TGFB2/SIX1/SEMA3C/BMP4/PIM1/TWIST1/FOXC1 7 BP GO:0048167 regulation of synaptic plasticity 20/1096 187/18670 0.006955 0.0343 0.02326 SERPINE2/SIPA1L1/EGR2/MECP2/STXBP1/LILRB2/PTK2B/CALB2/SHANK2/ADORA1/CD38/CX3CR1/PLK2/SYNGR1/NRGN/UNC13B/APOE/RIMS3/LGMN/ADCY1 20 BP GO:0016331 morphogenesis of embryonic epithelium 17/1096 150/18670 0.007009 0.03451 0.0234 TGFB2/SIX1/GATA3/SULF1/FZD2/RALA/AR/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 17 BP GO:0048754 branching morphogenesis of an epithelial tube 17/1096 150/18670 0.007009 0.03451 0.0234 VEGFA/SEMA3E/SIX1/DAG1/PAK1/MAGED1/AR/DLG5/CTSH/CAV3/HOXA5/BMP4/LRP5/CTNNBIP1/HOXA11/SPRY1/COL4A1 17 BP GO:0061008 hepaticobiliary system development 16/1096 138/18670 0.007056 0.03471 0.02354 TNFAIP3/TGFBR3/EGFR/PCK1/ADA/SMAD3/XBP1/RGN/ASS1/CCND1/SEC63/QDPR/JARID2/COBL/PCK2/JUN 16 BP GO:0001836 release of cytochrome c from mitochondria 9/1096 59/18670 0.00711 0.03474 0.02356 NOL3/TNFSF10/PINK1/GPX1/PLAUR/BAD/MLLT11/BNIP3/JUN 9 BP GO:0001885 endothelial cell development 9/1096 59/18670 0.00711 0.03474 0.02356 VEGFA/ICAM1/STC1/IL1B/CDH5/ID1/RAPGEF1/GPX1/PECAM1 9 BP GO:0031102 neuron projection regeneration 9/1096 59/18670 0.00711 0.03474 0.02356 SPP1/NTRK3/DAG1/INPP5F/THY1/PTPRF/LAMB2/JUN/GAP43 9 BP GO:0000305 response to oxygen radical 6/1096 30/18670 0.007111 0.03474 0.02356 GCH1/RGN/FBLN5/NQO1/FANCC/PRDX2 6 BP GO:0002828 regulation of type 2 immune response 6/1096 30/18670 0.007111 0.03474 0.02356 IL4R/GATA3/IL27RA/CCR2/CD86/NLRP3 6 BP GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 6/1096 30/18670 0.007111 0.03474 0.02356 RASGRP1/CD226/SH2D1A/CRTAM/LAG3/VAV1 6 BP GO:0090200 positive regulation of release of cytochrome c from mitochondria 6/1096 30/18670 0.007111 0.03474 0.02356 TNFSF10/PINK1/PLAUR/BAD/MLLT11/BNIP3 6 BP GO:1902751 positive regulation of cell cycle G2/M phase transition 6/1096 30/18670 0.007111 0.03474 0.02356 MECP2/CDC25B/CCND1/SMARCD3/CDK4/CCNB1 6 BP GO:0018958 phenol-containing compound metabolic process 13/1096 103/18670 0.007216 0.0352 0.02387 MAOA/TGFB2/FAH/GATA3/AKR1B1/GCH1/HPRT1/HDC/PNMT/MOXD1/DIO3/CRYM/ITGB2 13 BP GO:0001913 T cell mediated cytotoxicity 8/1096 49/18670 0.007237 0.0352 0.02387 IL7R/EMP2/FCGR2B/RAB27A/CTSC/PTPRC/HPRT1/CTSH 8 BP GO:0002686 negative regulation of leukocyte migration 8/1096 49/18670 0.007237 0.0352 0.02387 PLCB1/CD200/ADA/ADORA1/IL27RA/CXCL12/ABR/CCL2 8 BP GO:0071349 cellular response to interleukin-12 8/1096 49/18670 0.007237 0.0352 0.02387 PLCB1/LCP1/HNRNPDL/STAT4/RALA/PAK2/LMNB1/RPLP0 8 BP GO:0071825 protein-lipid complex subunit organization 8/1096 49/18670 0.007237 0.0352 0.02387 LPL/BIN1/LIPC/ABCG1/APOC1/PLA2G7/APOE/AGTR1 8 BP GO:0048705 skeletal system morphogenesis 24/1096 239/18670 0.007282 0.03539 0.024 SIX1/THRA/PCGF2/STC1/SMAD3/MGP/SFRP4/ALPL/COL1A1/FGFR1/HOXA5/BMP4/LRP5/DHRS3/TWIST1/FOXC1/CARM1/SFRP1/FGFR3/OSR2/PDGFRA/HOXA11/HYAL1/TCF15 24 BP GO:0048568 embryonic organ development 38/1096 428/18670 0.007347 0.03554 0.02411 RARRES2/TGFB2/VEGFA/EGFR/SIX1/ADA/GATA3/PCGF2/TCF7/SMAD3/ZIC1/RBP4/MAPK3/FZD2/ID3/CXCL8/FGFR1/GATA2/ERCC1/HOXA5/HIF1A/BMP4/EFEMP1/PHLDA2/BMPR1A/TWIST1/RAD23B/ABR/FOXC1/COBL/OSR2/SPINT2/PDGFRA/HOXA11/ST14/STIL/HYAL1/MBD2 38 BP GO:0030213 hyaluronan biosynthetic process 4/1096 14/18670 0.007356 0.03554 0.02411 IL1B/NFKB1/ABCC5/HYAL1 4 BP GO:0043374 CD8-positive, alpha-beta T cell differentiation 4/1096 14/18670 0.007356 0.03554 0.02411 RUNX3/IRF1/NCKAP1L/SATB1 4 BP GO:0046037 GMP metabolic process 4/1096 14/18670 0.007356 0.03554 0.02411 HPRT1/GUK1/IMPDH1/IMPDH2 4 BP GO:0050930 induction of positive chemotaxis 4/1096 14/18670 0.007356 0.03554 0.02411 VEGFA/CXCL8/NTF3/CXCL12 4 BP GO:0072498 embryonic skeletal joint development 4/1096 14/18670 0.007356 0.03554 0.02411 BMP4/OSR2/HOXA11/HYAL1 4 BP GO:0097202 activation of cysteine-type endopeptidase activity 4/1096 14/18670 0.007356 0.03554 0.02411 ASPH/BAD/LGMN/CYFIP2 4 BP GO:1904894 positive regulation of STAT cascade 12/1096 92/18670 0.007449 0.03596 0.02439 CCL5/IL7R/PTK2B/CD40/AKR1B1/HCLS1/MGAT5/F2R/PECAM1/FGFR3/CRLF1/IL15 12 BP GO:0001756 somitogenesis 10/1096 70/18670 0.007468 0.03599 0.02441 MEOX1/SMAD3/SEMA3C/LFNG/BMPR1A/PLXNA2/FOXC1/SFRP1/COBL/TCF15 10 BP GO:0032720 negative regulation of tumor necrosis factor production 10/1096 70/18670 0.007468 0.03599 0.02441 TNFAIP3/ADIPOQ/AXL/SLAMF1/PTPN6/IL27RA/GAS6/PTPN22/LBP/TWIST1 10 BP GO:0006720 isoprenoid metabolic process 16/1096 139/18670 0.007553 0.03628 0.0246 LPL/RARRES2/EGFR/ADH1B/AKR1B1/SDC1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/PMVK/GPC5/DHRS3/APOE/ALDH3A2 16 BP GO:0031333 negative regulation of protein complex assembly 16/1096 139/18670 0.007553 0.03628 0.0246 TMOD1/CRYAB/STXBP1/GSN/THRA/SPTBN1/CDH5/CAPG/KANK1/LDLRAD4/CTNNBIP1/STMN2/PPM1A/PFN2/TFIP11/SMAD6 16 BP GO:0007045 cell-substrate adherens junction assembly 11/1096 81/18670 0.007553 0.03628 0.0246 VEGFA/EPHA3/PTK2B/ACTN1/SMAD3/THY1/DLC1/EFNA5/CTTN/SFRP1/DUSP3 11 BP GO:0048041 focal adhesion assembly 11/1096 81/18670 0.007553 0.03628 0.0246 VEGFA/EPHA3/PTK2B/ACTN1/SMAD3/THY1/DLC1/EFNA5/CTTN/SFRP1/DUSP3 11 BP GO:0006986 response to unfolded protein 19/1096 176/18670 0.007607 0.0365 0.02476 CREB3L2/HSPB2/DAXX/XBP1/DNAJB5/HSPB1/CXCL8/CCND1/HSPA5/GFPT1/ATF6/KDELR3/THBS4/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1 19 BP GO:0001523 retinoid metabolic process 13/1096 104/18670 0.007817 0.03745 0.0254 LPL/RARRES2/ADH1B/AKR1B1/SDC1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/GPC5/DHRS3/APOE 13 BP GO:0014812 muscle cell migration 13/1096 104/18670 0.007817 0.03745 0.0254 PARVA/CCL5/P2RY6/ADIPOQ/SIX1/POSTN/PAK1/IGFBP5/PRKG1/SERPINE1/HDAC4/BMPR1A/THBS4 13 BP GO:0010226 response to lithium ion 5/1096 22/18670 0.00787 0.03745 0.0254 FABP4/PTK2B/ACTA1/IGFBP2/ADCY1 5 BP GO:0010869 regulation of receptor biosynthetic process 5/1096 22/18670 0.00787 0.03745 0.0254 ITGAV/ADIPOQ/HOXA5/HIF1A/HDAC1 5 BP GO:0030878 thyroid gland development 5/1096 22/18670 0.00787 0.03745 0.0254 SIX1/THRA/SMAD3/MAPK3/HOXA5 5 BP GO:0033622 integrin activation 5/1096 22/18670 0.00787 0.03745 0.0254 CXCL13/PLEK/SKAP1/CXCL12/SELP 5 BP GO:0042094 interleukin-2 biosynthetic process 5/1096 22/18670 0.00787 0.03745 0.0254 IL1B/PTPRC/LAG3/CD86/GLMN 5 BP GO:0045649 regulation of macrophage differentiation 5/1096 22/18670 0.00787 0.03745 0.0254 ADIPOQ/HCLS1/GATA2/PF4/PTPN2 5 BP GO:0060065 uterus development 5/1096 22/18670 0.00787 0.03745 0.0254 HOXA10/TGFB2/GATA3/RBP4/HOXA11 5 BP GO:0097205 renal filtration 5/1096 22/18670 0.00787 0.03745 0.0254 EMP2/SULF1/ADORA1/GAS6/F2R 5 BP GO:1902806 regulation of cell cycle G1/S phase transition 21/1096 202/18670 0.007932 0.03771 0.02558 PLCB1/EGFR/CDK10/BTG2/CCND2/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/PLK2/PAF1/CDK4/CCNB1/CNOT4/CARM1/CCL2/FHL1/CUL4A/HYAL1/CDC6 21 BP GO:1902808 positive regulation of cell cycle G1/S phase transition 9/1096 60/18670 0.007941 0.03772 0.02559 PLCB1/EGFR/CDK10/CCND2/CCND1/PAF1/CUL4A/HYAL1/CDC6 9 BP GO:0030902 hindbrain development 17/1096 152/18670 0.007975 0.03785 0.02568 SERPINE2/EGR2/MECP2/NFIB/ZNF365/FCGR2B/PAK1/MYH10/HSPA5/SMAD1/B4GALT2/GATA2/DLC1/RERE/PLXNA2/FOXC1/ATF5 17 BP GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/1096 40/18670 0.008004 0.03793 0.02573 IL4R/IL7R/FCGR2B/PTPN6/IL27RA/PTPRC/PARP3 7 BP GO:0090184 positive regulation of kidney development 7/1096 40/18670 0.008004 0.03793 0.02573 VEGFA/ADIPOQ/SIX1/GATA3/MAGED1/BMP4/BASP1 7 BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 24/1096 241/18670 0.008044 0.03809 0.02583 TGFBR3/MAGI2/WWTR1/TGFB2/SMAD3/SULF1/SFRP4/SPTBN1/HSPA5/CDH5/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/BMP4/HTRA1/GDF10/BMPR1A/SFRP1/PPM1A/SMAD6/INHBB/ADAMTSL2 24 BP GO:0097553 calcium ion transmembrane import into cytosol 16/1096 140/18670 0.008077 0.03821 0.02592 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0003073 regulation of systemic arterial blood pressure 12/1096 93/18670 0.008109 0.0383 0.02597 CPA3/MECP2/NCALD/EMP2/POSTN/ADORA1/AR/GAS6/F2R/SLC2A5/HSD11B2/AGTR1 12 BP GO:0046634 regulation of alpha-beta T cell activation 12/1096 93/18670 0.008109 0.0383 0.02597 RUNX3/IL4R/ZBTB16/ADA/IRF1/GATA3/PTPRC/CD83/CCR2/NCKAP1L/CD86/NLRP3 12 BP GO:0009409 response to cold 8/1096 50/18670 0.008183 0.03852 0.02613 FOXO1/LPL/THRA/CIRBP/NFKBIA/UCP2/NFE2L1/CXCL10 8 BP GO:0070671 response to interleukin-12 8/1096 50/18670 0.008183 0.03852 0.02613 PLCB1/LCP1/HNRNPDL/STAT4/RALA/PAK2/LMNB1/RPLP0 8 BP GO:0070741 response to interleukin-6 8/1096 50/18670 0.008183 0.03852 0.02613 PCK1/ICAM1/SELPLG/NFKB1/CHI3L1/PHB/STAT1/PTPN2 8 BP GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 8/1096 50/18670 0.008183 0.03852 0.02613 PLCB1/EGFR/CDK10/CCND2/CCND1/CUL4A/HYAL1/CDC6 8 BP GO:0010976 positive regulation of neuron projection development 27/1096 281/18670 0.008217 0.03865 0.02621 CREB3L2/CXCR4/MAGI2/SEMA5A/VEGFA/EPHA3/NTRK3/PTK2B/CUX1/SHANK2/PAK1/NEDD4L/S100A9/RGS2/HSPA5/FGFR1/DLG5/SYT17/RAPGEF1/EFNA5/APOE/NGF/PLXNC1/STMN2/PLXNA2/CXCL12/COBL 27 BP GO:0032642 regulation of chemokine production 11/1096 82/18670 0.008274 0.03888 0.02637 IL4R/LPL/ADIPOQ/IL1B/POSTN/CXCL6/HIF1A/TLR2/LBP/TWIST1/ELANE 11 BP GO:0031668 cellular response to extracellular stimulus 26/1096 268/18670 0.00832 0.03907 0.0265 FOXO1/LPL/AXL/PCK1/ICAM1/NAMPT/POSTN/XBP1/MAPK3/SIK1/DAP/HSPA5/PTPRC/PDK2/ITGA4/COL1A1/GABARAPL1/GAS6/PIM1/EHMT2/WDR45/SFRP1/NPRL3/INHBB/IL15/JUN 26 BP GO:0007266 Rho protein signal transduction 21/1096 203/18670 0.008374 0.03907 0.0265 RAC2/RHOH/ARHGEF10/RHOBTB3/DNMBP/ARHGAP1/PDPN/ARHGDIB/TNFAIP1/KANK1/F2R/DLC1/PECAM1/RHOBTB1/APOE/ABR/AGTR1/ARHGAP5/ARHGEF5/VAV1/COL3A1 21 BP GO:0002888 positive regulation of myeloid leukocyte mediated immunity 6/1096 31/18670 0.008388 0.03907 0.0265 IL4R/STXBP1/GAB2/PTAFR/GATA2/ITGB2 6 BP GO:0003299 muscle hypertrophy in response to stress 6/1096 31/18670 0.008388 0.03907 0.0265 FOXO1/SMAD3/MYH7/INPP5F/HDAC4/CAMTA2 6 BP GO:0014887 cardiac muscle adaptation 6/1096 31/18670 0.008388 0.03907 0.0265 FOXO1/SMAD3/MYH7/INPP5F/HDAC4/CAMTA2 6 BP GO:0014898 cardiac muscle hypertrophy in response to stress 6/1096 31/18670 0.008388 0.03907 0.0265 FOXO1/SMAD3/MYH7/INPP5F/HDAC4/CAMTA2 6 BP GO:0034694 response to prostaglandin 6/1096 31/18670 0.008388 0.03907 0.0265 TGFBR3/P2RY6/CCR7/ADCY6/PTGER2/SFRP1 6 BP GO:0043304 regulation of mast cell degranulation 6/1096 31/18670 0.008388 0.03907 0.0265 IL4R/RAC2/STXBP1/GAB2/GATA2/STXBP2 6 BP GO:0045648 positive regulation of erythrocyte differentiation 6/1096 31/18670 0.008388 0.03907 0.0265 GATA2/HIF1A/NCKAP1L/STAT1/INPP5D/TRIM58 6 BP GO:1903319 positive regulation of protein maturation 6/1096 31/18670 0.008388 0.03907 0.0265 ADAM8/GSN/IL1B/PHB/C6/TNP2 6 BP GO:1903393 positive regulation of adherens junction organization 6/1096 31/18670 0.008388 0.03907 0.0265 VEGFA/MAPRE2/SMAD3/THY1/SFRP1/DUSP3 6 BP GO:0001841 neural tube formation 13/1096 105/18670 0.008456 0.03925 0.02662 TGFB2/FZD2/RALA/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 13 BP GO:0002708 positive regulation of lymphocyte mediated immunity 13/1096 105/18670 0.008456 0.03925 0.02662 RASGRP1/CD226/GATA3/SH2D1A/CD40/IL1B/TP53BP1/PTPRC/CRTAM/LAG3/NLRP3/VAV1/TFRC 13 BP GO:0006641 triglyceride metabolic process 13/1096 105/18670 0.008456 0.03925 0.02662 LPL/FABP4/PCK1/SIK1/GK/RGN/LIPC/PNPLA4/APOC1/CAV3/GPX1/APOE/PCK2 13 BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 13/1096 105/18670 0.008456 0.03925 0.02662 ANGPT1/VEGFA/EGFR/NTRK3/PAK1/CD44/HCLS1/GAS6/AKAP9/PINK1/NTF3/TENM1/PFN2 13 BP GO:0062013 positive regulation of small molecule metabolic process 17/1096 153/18670 0.008497 0.03941 0.02673 FOXO1/ZBTB20/P2RY6/ADIPOQ/NUPR1/IL1B/RGN/NFKB1/PTAFR/ABCG1/INSR/HIF1A/DYRK2/PINK1/CCNB1/TWIST1/PTPN2 17 BP GO:0010508 positive regulation of autophagy 14/1096 117/18670 0.008636 0.04002 0.02715 FOXO1/PIP4K2B/HK2/MAPK3/MID2/PLK2/HIF1A/PINK1/BAD/PIM2/KAT5/BNIP3/IKBKG/SUPT5H 14 BP GO:1901216 positive regulation of neuron death 12/1096 94/18670 0.008813 0.04081 0.02768 TGFB2/FCGR2B/NUPR1/DAXX/ADORA1/PIN1/NQO1/BAD/HDAC4/DDIT4/ITGB2/JUN 12 BP GO:0071241 cellular response to inorganic substance 22/1096 217/18670 0.008892 0.04114 0.0279 FOXO1/FABP4/GSN/EGFR/ANK3/CPNE1/ATRX/DAXX/MAPK3/HSPA5/MT1G/SYT17/CCNA2/NQO1/NFE2L1/CCNB1/AQP1/BAD/LGMN/BNIP3/JUN/ADCY1 22 BP GO:0045913 positive regulation of carbohydrate metabolic process 11/1096 83/18670 0.009047 0.04182 0.02837 FOXO1/ZBTB20/P2RY6/RGN/NFKB1/PTAFR/INSR/HIF1A/DYRK2/BAD/PTPN2 11 BP GO:0050805 negative regulation of synaptic transmission 10/1096 72/18670 0.009088 0.04191 0.02843 STXBP1/ADIPOQ/LILRB2/PTK2B/IL1B/SHANK2/ADORA1/CD38/PLK2/PCDH17 10 BP GO:0061035 regulation of cartilage development 10/1096 72/18670 0.009088 0.04191 0.02843 ZBTB16/SOX5/LOXL2/SMAD3/PTHLH/SMAD1/BMP4/EFEMP1/CARM1/HOXA11 10 BP GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 10/1096 72/18670 0.009088 0.04191 0.02843 TNFAIP3/ADIPOQ/AXL/SLAMF1/PTPN6/IL27RA/GAS6/PTPN22/LBP/TWIST1 10 BP GO:0003002 regionalization 32/1096 351/18670 0.009129 0.042 0.02849 ZBTB16/EGR2/HOXA10/CDON/SEMA3A/SIX1/PCGF2/MEOX1/SMAD3/BTG2/AR/FGFR1/SEMA3C/SMARCD3/HOXA5/BMP4/ETS2/LFNG/LRP5/BASP1/CTNNBIP1/BMPR1A/PLXNA2/FOXC1/SFRP1/NRP2/COBL/HOXA11/RING1/SPRY1/SMAD6/TCF15 32 BP GO:0002286 T cell activation involved in immune response 13/1096 106/18670 0.009136 0.042 0.02849 IL4R/RELB/ICAM1/LCP1/GATA3/FCGR2B/GPR183/ITGAL/BATF/RAB27A/HLA-DMB/CD86/NLRP3 13 BP GO:1901606 alpha-amino acid catabolic process 13/1096 106/18670 0.009136 0.042 0.02849 ALDH6A1/FAH/GOT2/HPD/CDO1/HDC/ASPA/PCBD1/GOT1/AHCY/QDPR/CRYM/SDS 13 BP GO:0007520 myoblast fusion 7/1096 41/18670 0.009175 0.042 0.02849 IL4R/CDON/CD53/CAV3/ADAM12/CXCL10/TNFSF14 7 BP GO:0034122 negative regulation of toll-like receptor signaling pathway 7/1096 41/18670 0.009175 0.042 0.02849 TNFAIP3/LY96/MFHAS1/CD14/LILRA2/GRAMD4/TYRO3 7 BP GO:0043267 negative regulation of potassium ion transport 7/1096 41/18670 0.009175 0.042 0.02849 ANK3/BIN1/PTK2B/NEDD4L/CASQ2/KCNAB1/CAV3 7 BP GO:0150077 regulation of neuroinflammatory response 7/1096 41/18670 0.009175 0.042 0.02849 TNFRSF1B/CD200/NUPR1/IL1B/CTSC/PTPRC/CST7 7 BP GO:0034332 adherens junction organization 16/1096 142/18670 0.009213 0.042 0.02849 VEGFA/EPHA3/MAPRE2/PTK2B/ACTN1/SMAD3/CDH5/DLG5/THY1/DLC1/EFNA5/CTTN/CSK/CDH2/SFRP1/DUSP3 16 BP GO:0050871 positive regulation of B cell activation 16/1096 142/18670 0.009213 0.042 0.02849 TRBC1/ADA/CD40/TP53BP1/XBP1/GPR183/CD38/PTPRC/CD27/TNFRSF4/IGKC/NCKAP1L/BAD/INPP5D/TFRC/IGLC1 16 BP GO:1902904 negative regulation of supramolecular fiber organization 16/1096 142/18670 0.009213 0.042 0.02849 TMOD1/CORO1A/CRYAB/GSN/S1PR1/SPTBN1/CDH5/CAPG/KANK1/CAV3/CAMSAP2/DLC1/GMFG/APOE/STMN2/PFN2 16 BP GO:0031103 axon regeneration 8/1096 51/18670 0.009219 0.042 0.02849 SPP1/NTRK3/DAG1/INPP5F/PTPRF/LAMB2/JUN/GAP43 8 BP GO:0048260 positive regulation of receptor-mediated endocytosis 8/1096 51/18670 0.009219 0.042 0.02849 MAGI2/ANGPT1/VEGFA/SFRP4/PLCG2/NTF3/HIP1/SERPINE1 8 BP GO:0050999 regulation of nitric-oxide synthase activity 8/1096 51/18670 0.009219 0.042 0.02849 EGFR/PTK2B/IL1B/GCH1/CAV3/HIF1A/APOE/LYPLA1 8 BP GO:0072523 purine-containing compound catabolic process 8/1096 51/18670 0.009219 0.042 0.02849 PDE1A/ADA/AMPD3/HPRT1/GPX1/AHCY/PDE9A/NUDT3 8 BP GO:0097366 response to bronchodilator 8/1096 51/18670 0.009219 0.042 0.02849 FOXO1/ICAM1/CCR7/RGS2/HPRT1/CCNA2/AQP1/SLC18A2 8 BP GO:0032886 regulation of microtubule-based process 22/1096 218/18670 0.00936 0.04261 0.0289 MECP2/ARL2/EPHA3/MAPRE2/GPSM2/PAK1/MAPRE3/CDH5/PLK2/CAV3/AKAP9/CAMSAP2/EFNA5/PARP3/STMN2/SPAG5/TPX2/PLK1/SPICE1/TRIM58/STIL/ATF5 22 BP GO:0021700 developmental maturation 27/1096 284/18670 0.009397 0.04275 0.029 XYLT1/MECP2/TGFB2/STXBP1/VEGFA/AXL/CLSTN1/GATA3/PTK2B/DAG1/S1PR1/XBP1/CDC25B/CDH5/CX3CR1/FGFR1/GATA2/HOXA5/HIF1A/UNC13B/NFIA/CCNB1/RERE/CCR6/FGFR3/TRIM58/IL15 27 BP GO:0002467 germinal center formation 4/1096 15/18670 0.009572 0.04296 0.02914 TNFAIP3/CXCL13/ADA/NFKB2 4 BP GO:0010759 positive regulation of macrophage chemotaxis 4/1096 15/18670 0.009572 0.04296 0.02914 CCL5/RARRES2/MAPK3/C3AR1 4 BP GO:0014874 response to stimulus involved in regulation of muscle adaptation 4/1096 15/18670 0.009572 0.04296 0.02914 SGCA/DAG1/NOL3/HDAC4 4 BP GO:0030852 regulation of granulocyte differentiation 4/1096 15/18670 0.009572 0.04296 0.02914 ADIPOQ/HCLS1/INPP5D/CUL4A 4 BP GO:0033008 positive regulation of mast cell activation involved in immune response 4/1096 15/18670 0.009572 0.04296 0.02914 IL4R/STXBP1/GAB2/GATA2 4 BP GO:0043101 purine-containing compound salvage 4/1096 15/18670 0.009572 0.04296 0.02914 ADA/AMPD3/HPRT1/DCK 4 BP GO:0043306 positive regulation of mast cell degranulation 4/1096 15/18670 0.009572 0.04296 0.02914 IL4R/STXBP1/GAB2/GATA2 4 BP GO:0051044 positive regulation of membrane protein ectodomain proteolysis 4/1096 15/18670 0.009572 0.04296 0.02914 TNFRSF1B/ADAM8/IL1B/APOE 4 BP GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 4/1096 15/18670 0.009572 0.04296 0.02914 NAMPT/TLR2/STAT1/CCL2 4 BP GO:0051883 killing of cells in other organism involved in symbiotic interaction 4/1096 15/18670 0.009572 0.04296 0.02914 CXCL6/PF4/BAD/ELANE 4 BP GO:0055089 fatty acid homeostasis 4/1096 15/18670 0.009572 0.04296 0.02914 XBP1/ADORA1/GOT1/APOE 4 BP GO:0071474 cellular hyperosmotic response 4/1096 15/18670 0.009572 0.04296 0.02914 AKR1B1/EFHD1/AQP1/MAPK10 4 BP GO:0009068 aspartate family amino acid catabolic process 5/1096 23/18670 0.009579 0.04296 0.02914 GOT2/ASPA/GOT1/CRYM/SDS 5 BP GO:0009595 detection of biotic stimulus 5/1096 23/18670 0.009579 0.04296 0.02914 LY96/CRTAM/TLR2/LBP/NLRP3 5 BP GO:0019400 alditol metabolic process 5/1096 23/18670 0.009579 0.04296 0.02914 PCK1/AKR1B1/GK/GOT1/PCK2 5 BP GO:0032959 inositol trisphosphate biosynthetic process 5/1096 23/18670 0.009579 0.04296 0.02914 PLCB1/P2RY6/PTK2B/PTAFR/PLCG2 5 BP GO:0060445 branching involved in salivary gland morphogenesis 5/1096 23/18670 0.009579 0.04296 0.02914 SEMA3A/DAG1/TGM2/FGFR1/SEMA3C 5 BP GO:0072215 regulation of metanephros development 5/1096 23/18670 0.009579 0.04296 0.02914 WWTR1/ADIPOQ/BMP4/BASP1/STAT1 5 BP GO:1901862 negative regulation of muscle tissue development 9/1096 62/18670 0.009821 0.04381 0.02971 PAK1/RBP4/RGS2/CAV3/BMP4/FZD7/IGFBP5/JARID2/TWIST1 9 BP GO:0033006 regulation of mast cell activation involved in immune response 6/1096 32/18670 0.009823 0.04381 0.02971 IL4R/RAC2/STXBP1/GAB2/GATA2/STXBP2 6 BP GO:0042311 vasodilation 6/1096 32/18670 0.009823 0.04381 0.02971 ADORA1/GCH1/RGS2/GPX1/PRKG1/APOE 6 BP GO:0045907 positive regulation of vasoconstriction 6/1096 32/18670 0.009823 0.04381 0.02971 EGFR/ICAM1/PTAFR/CD38/F2R/CHRM3 6 BP GO:0051968 positive regulation of synaptic transmission, glutamatergic 6/1096 32/18670 0.009823 0.04381 0.02971 STXBP1/EGFR/PTK2B/SHANK2/CCR2/CCL2 6 BP GO:0071295 cellular response to vitamin 6/1096 32/18670 0.009823 0.04381 0.02971 POSTN/COL1A1/GAS6/PIM1/SFRP1/IL15 6 BP GO:2000778 positive regulation of interleukin-6 secretion 6/1096 32/18670 0.009823 0.04381 0.02971 LPL/IL1B/XBP1/LILRA2/F2R/TWIST1 6 BP GO:0051341 regulation of oxidoreductase activity 13/1096 107/18670 0.009858 0.04393 0.0298 EGFR/AOC3/PTK2B/IL1B/GCH1/RGN/GZMA/NFKB1/CAV3/HIF1A/APOE/AGTR1/LYPLA1 13 BP GO:0045445 myoblast differentiation 11/1096 84/18670 0.009874 0.04397 0.02982 PLCB1/CDON/TCF7L2/SDC1/ID3/PITX1/KCNAB1/TRIP4/BMP4/CXCL10/TNFSF14 11 BP GO:0050688 regulation of defense response to virus 10/1096 73/18670 0.009993 0.04446 0.03016 TNFAIP3/AIM2/BIRC3/IL1B/PCBP2/HTRA1/STAT1/TRAF3/IL2RA/IL15 10 BP GO:0032330 regulation of chondrocyte differentiation 8/1096 52/18670 0.01035 0.04598 0.03118 ZBTB16/SOX5/LOXL2/SMAD3/PTHLH/BMP4/EFEMP1/HOXA11 8 BP GO:0072132 mesenchyme morphogenesis 8/1096 52/18670 0.01035 0.04598 0.03118 TGFB2/SMAD3/FGFR1/ACTA2/ACTA1/BMPR1A/TWIST1/FOXC1 8 BP GO:0010470 regulation of gastrulation 7/1096 42/18670 0.01047 0.04635 0.03144 ADIPOQ/IL1RN/DAG1/FGFR1/MAPK7/FZD7/BMPR1A 7 BP GO:0010677 negative regulation of cellular carbohydrate metabolic process 7/1096 42/18670 0.01047 0.04635 0.03144 ADIPOQ/ENPP1/NUPR1/PLEK/SIK1/HDAC4/DDIT4 7 BP GO:0051154 negative regulation of striated muscle cell differentiation 7/1096 42/18670 0.01047 0.04635 0.03144 PAK1/XBP1/RGS2/CAV3/FZD7/CXCL10/HDAC4 7 BP GO:0097028 dendritic cell differentiation 7/1096 42/18670 0.01047 0.04635 0.03144 RELB/AXL/LILRB2/FCGR2B/CCR7/BATF/GAS6 7 BP GO:0032526 response to retinoic acid 13/1096 108/18670 0.01062 0.04697 0.03186 EPHA3/PCK1/NTRK3/PTK2B/IGFBP7/RBP4/CD38/COL1A1/CTSH/IGFBP2/FZD7/AQP1/RXRA 13 BP GO:0003158 endothelium development 15/1096 132/18670 0.01064 0.04697 0.03186 CXCR4/VEGFA/ICAM1/ITGAX/STC1/IL1B/S1PR1/CDH5/PDPN/ID1/RAPGEF1/BMP4/GPX1/PECAM1/CXCL10 15 BP GO:0042552 myelination 15/1096 132/18670 0.01064 0.04697 0.03186 TNFRSF1B/CXCR4/EGR2/NDRG1/NTRK3/ARHGEF10/ITGAX/DAG1/CTSC/CST7/ASPA/ID4/TSPAN2/TLR2/TYMP 15 BP GO:0072175 epithelial tube formation 15/1096 132/18670 0.01064 0.04697 0.03186 TGFB2/SIX1/GATA3/FZD2/RALA/HIF1A/BMP4/DLC1/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 15 BP GO:1903362 regulation of cellular protein catabolic process 24/1096 247/18670 0.01073 0.04735 0.03211 TNFAIP3/PTK2B/NUPR1/NELL1/RGN/RNF144A/CTSC/TRIB2/PLK2/CAV3/PINK1/LAMP3/GPX1/NFE2L1/CAMLG/UBE2J1/USP7/APOE/RAD23B/PLK1/USP5/HERPUD1/PTTG1IP/GLMN 24 BP GO:0034308 primary alcohol metabolic process 11/1096 85/18670 0.01076 0.04743 0.03217 ADH1B/AKR1B1/RBP4/ADH1A/ADH1C/PNPLA4/ALDH3B1/AKR7A2/AKR1B10/DHRS3/ALDH3A2 11 BP GO:0016485 protein processing 30/1096 328/18670 0.01085 0.04781 0.03243 SERPINE2/CPA3/ADAM8/SRGN/GSN/CFB/BIRC3/IL1B/NOL3/ADAMTS2/ADAMTS3/ASPH/CFP/CST7/CTSH/GAS1/IGKC/CFI/PHB/BAD/NGF/SERPINE1/IGLV6-57/C6/IGLC1/C7/LGMN/C3AR1/CYFIP2/TNP2 30 BP GO:0046637 regulation of alpha-beta T cell differentiation 9/1096 63/18670 0.01088 0.04784 0.03245 RUNX3/IL4R/ZBTB16/ADA/GATA3/CD83/NCKAP1L/CD86/NLRP3 9 BP GO:0046686 response to cadmium ion 9/1096 63/18670 0.01088 0.04784 0.03245 GSN/EGFR/DAXX/MAPK3/NPC1/MT1G/ERCC1/GOT1/JUN 9 BP GO:0050792 regulation of viral process 21/1096 208/18670 0.01089 0.04787 0.03247 FCN1/CXCR4/CCL5/GSN/SLPI/CXCL8/MID2/PLSCR1/ISG20/PC/LAMP3/POLR2E/HDAC1/STAT1/APOE/APCS/POLR2I/TFAP4/VAPA/JUN/SUPT5H 21 BP GO:0006022 aminoglycan metabolic process 18/1096 170/18670 0.01114 0.04893 0.03319 UST/XYLT1/ANGPT1/SPOCK2/IL1B/SDC1/NFKB1/CD44/B4GALT2/CHST3/PIM1/ABCC5/GPC5/HEXA/FOXC1/UGDH/HYAL1/IL15 18 BP GO:0010771 negative regulation of cell morphogenesis involved in differentiation 12/1096 97/18670 0.01122 0.04918 0.03336 SPP1/SEMA5A/SEMA3E/SEMA3A/POSTN/ID1/KANK1/SEMA3C/THY1/SEMA4F/EFNA5/GBP1 12 BP GO:0090630 activation of GTPase activity 12/1096 97/18670 0.01122 0.04918 0.03336 SIPA1L1/CXCL13/RASGRP1/NTRK3/ARHGEF10/PTK2B/CCR7/RAPGEF1/NTF3/TBC1D4/SGSM2/ABR 12 BP GO:0046434 organophosphate catabolic process 24/1096 248/18670 0.01124 0.04926 0.03341 ZBTB20/PDE1A/ENPP1/ADA/NUPR1/PFKM/HK2/PNPLA6/LIPC/AMPD3/INSR/PLCG2/HPRT1/APOC1/INPP5F/HIF1A/GPX1/PDE9A/HDAC4/DDIT4/NUP210/PLA2G15/ALDOA/NUDT3 24 BP GO:0042770 signal transduction in response to DNA damage 15/1096 133/18670 0.01136 0.04974 0.03373 NDRG1/ATRX/BTG2/BATF/CNOT1/CD44/PLK2/CCNB1/KAT5/TWIST1/CNOT4/CARM1/TFAP4/PLK1/PTTG1IP 15 BP GO:0002717 positive regulation of natural killer cell mediated immunity 6/1096 33/18670 0.01142 0.04974 0.03374 RASGRP1/CD226/SH2D1A/CRTAM/LAG3/VAV1 6 BP GO:0030851 granulocyte differentiation 6/1096 33/18670 0.01142 0.04974 0.03374 ADIPOQ/HCLS1/GATA2/LBR/INPP5D/CUL4A 6 BP GO:0031112 positive regulation of microtubule polymerization or depolymerization 6/1096 33/18670 0.01142 0.04974 0.03374 MECP2/ARL2/PAK1/CAV3/AKAP9/STMN2 6 BP GO:0033028 myeloid cell apoptotic process 6/1096 33/18670 0.01142 0.04974 0.03374 CCL5/ADIPOQ/THRA/CCR5/CTSL/IRF7 6 BP GO:0045191 regulation of isotype switching 6/1096 33/18670 0.01142 0.04974 0.03374 CD40/TP53BP1/IL27RA/PTPRC/PARP3/TFRC 6 BP GO:0048011 neurotrophin TRK receptor signaling pathway 6/1096 33/18670 0.01142 0.04974 0.03374 NTRK3/NTF3/NGF/DDIT4/SPRY1/CYFIP2 6 BP GO:1901380 negative regulation of potassium ion transmembrane transport 6/1096 33/18670 0.01142 0.04974 0.03374 ANK3/BIN1/NEDD4L/CASQ2/KCNAB1/CAV3 6 BP GO:1901605 alpha-amino acid metabolic process 22/1096 222/18670 0.01144 0.04976 0.03375 ALDH6A1/MECP2/FAH/ASS1/GOT2/HPD/GFPT1/BCAT1/CDO1/HDC/ALDH5A1/ASPA/PCBD1/CRTAP/GOT1/AHCY/QDPR/CKMT2/CRYM/TST/SDS/AHCYL2 22 BP GO:0010811 positive regulation of cell-substrate adhesion 14/1096 121/18670 0.01147 0.04982 0.03379 ARL2/VEGFA/SPOCK2/EMP2/PTK2B/DAG1/SMAD3/CCR7/DOCK1/SKAP1/THY1/ITGA5/NINJ1/SFRP1 14 BP GO:0030968 endoplasmic reticulum unfolded protein response 14/1096 121/18670 0.01147 0.04982 0.03379 CREB3L2/XBP1/CXCL8/CCND1/HSPA5/GFPT1/ATF6/KDELR3/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1 14 BP GO:0003181 atrioventricular valve morphogenesis 5/1096 24/18670 0.01153 0.04985 0.03381 TGFB2/OLFM1/BMPR1A/TWIST1/SMAD6 5 BP GO:0032878 regulation of establishment or maintenance of cell polarity 5/1096 24/18670 0.01153 0.04985 0.03381 GSN/GATA3/PTK2B/CDH5/KANK1 5 BP GO:0032897 negative regulation of viral transcription 5/1096 24/18670 0.01153 0.04985 0.03381 CCL5/MID2/HDAC1/TFAP4/JUN 5 BP GO:0035588 G protein-coupled purinergic receptor signaling pathway 5/1096 24/18670 0.01153 0.04985 0.03381 P2RY6/ADA/ADORA3/ADORA1/PTAFR 5 BP GO:0046475 glycerophospholipid catabolic process 5/1096 24/18670 0.01153 0.04985 0.03381 PNPLA6/LIPC/APOC1/INPP5F/PLA2G15 5 BP GO:0060343 trabecula formation 5/1096 24/18670 0.01153 0.04985 0.03381 TGFBR3/RBP4/COL1A1/CAV3/SFRP1 5 BP GO:0000186 activation of MAPKK activity 8/1096 53/18670 0.01158 0.04985 0.03381 EGFR/MAPK3/ADORA1/MAP3K4/RAPGEF1/F2R/BMP4/NGF 8 BP GO:0038066 p38MAPK cascade 8/1096 53/18670 0.01158 0.04985 0.03381 VEGFA/PHLPP1/IL1B/MAP3K4/MFHAS1/SASH1/PTPN22/CAV3 8 BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 8/1096 53/18670 0.01158 0.04985 0.03381 CCL5/GPRASP1/ADA/PLEK/CXCL8/RGS2/RGS13/DNM1 8 BP GO:0070228 regulation of lymphocyte apoptotic process 8/1096 53/18670 0.01158 0.04985 0.03381 CCL5/ADAM8/IL7R/ADA/CD3G/CD27/HIF1A/BMP4 8 BP GO:1901185 negative regulation of ERBB signaling pathway 8/1096 53/18670 0.01158 0.04985 0.03381 TGFA/EGFR/HBEGF/BTC/LGMN/DUSP3/PTPN2/SPRY1 8 BP GO:1903307 positive regulation of regulated secretory pathway 8/1096 53/18670 0.01158 0.04985 0.03381 IL4R/STXBP1/GAB2/RAB27A/PTAFR/GATA2/UNC13B/ITGB2 8 BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 11/1096 86/18670 0.0117 0.05034 0.03414 TNFAIP3/TNFRSF10B/ICAM1/DAXX/TNFSF10/GPX1/TIMP3/BAD/NGF/SERPINE1/SFRP1 11 BP GO:0045834 positive regulation of lipid metabolic process 16/1096 146/18670 0.01186 0.05097 0.03457 ZBTB20/ADIPOQ/PTK2B/IL1B/CCR7/ADORA1/RGN/ABCG1/APOC1/EEF1A2/APOE/TWIST1/AGTR1/FGFR3/PDGFRA/FLT1 16 BP GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/1096 43/18670 0.01188 0.05097 0.03457 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0086004 regulation of cardiac muscle cell contraction 7/1096 43/18670 0.01188 0.05097 0.03457 BIN1/STC1/ADORA1/PLN/CAV3/AKAP9/ATP2A1 7 BP GO:1904646 cellular response to amyloid-beta 7/1096 43/18670 0.01188 0.05097 0.03457 ICAM1/FCGR2B/NAMPT/BCL2L2/ITGA4/CASP4/LGMN 7 BP GO:0002200 somatic diversification of immune receptors 10/1096 75/18670 0.01201 0.05138 0.03485 CD40/TCF7/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 10 BP GO:0016445 somatic diversification of immunoglobulins 9/1096 64/18670 0.01202 0.05138 0.03485 CD40/TP53BP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/CCR6/TFRC 9 BP GO:0032768 regulation of monooxygenase activity 9/1096 64/18670 0.01202 0.05138 0.03485 EGFR/PTK2B/IL1B/GCH1/NFKB1/CAV3/HIF1A/APOE/LYPLA1 9 BP GO:0046503 glycerolipid catabolic process 9/1096 64/18670 0.01202 0.05138 0.03485 LPL/FABP4/PNPLA6/LIPC/PNPLA4/APOC1/INPP5F/APOE/PLA2G15 9 BP GO:0010876 lipid localization 35/1096 400/18670 0.01209 0.05146 0.0349 SPP1/LPL/GULP1/FTO/ATP9A/ABCC3/FABP4/ITGAV/ADIPOQ/ABCA8/ENPP1/UGCG/IL1B/RBP4/ABCA3/NFKBIA/HDLBP/NFKB1/GOT2/NMB/ESYT1/LIPC/NPC1/AQP9/ABCG1/SLC27A2/APOC1/STOML1/APOE/LBP/APOF/AGTR1/PTPN2/RXRA/IKBKE 35 BP GO:0007272 ensheathment of neurons 15/1096 134/18670 0.01212 0.05146 0.0349 TNFRSF1B/CXCR4/EGR2/NDRG1/NTRK3/ARHGEF10/ITGAX/DAG1/CTSC/CST7/ASPA/ID4/TSPAN2/TLR2/TYMP 15 BP GO:0008366 axon ensheathment 15/1096 134/18670 0.01212 0.05146 0.0349 TNFRSF1B/CXCR4/EGR2/NDRG1/NTRK3/ARHGEF10/ITGAX/DAG1/CTSC/CST7/ASPA/ID4/TSPAN2/TLR2/TYMP 15 BP GO:0002830 positive regulation of type 2 immune response 4/1096 16/18670 0.01218 0.05146 0.0349 IL4R/GATA3/CD86/NLRP3 4 BP GO:0006957 complement activation, alternative pathway 4/1096 16/18670 0.01218 0.05146 0.0349 CFB/CFP/CFD/C7 4 BP GO:0010820 positive regulation of T cell chemotaxis 4/1096 16/18670 0.01218 0.05146 0.0349 CCL5/CXCL13/CCR2/TNFSF14 4 BP GO:0010875 positive regulation of cholesterol efflux 4/1096 16/18670 0.01218 0.05146 0.0349 ADIPOQ/NFKBIA/ABCG1/APOE 4 BP GO:0010919 regulation of inositol phosphate biosynthetic process 4/1096 16/18670 0.01218 0.05146 0.0349 P2RY6/PTK2B/PLEK/PTAFR 4 BP GO:0019372 lipoxygenase pathway 4/1096 16/18670 0.01218 0.05146 0.0349 LTC4S/GPX4/GPX1/ALOX5 4 BP GO:0030397 membrane disassembly 4/1096 16/18670 0.01218 0.05146 0.0349 PRKCB/CCNB1/PLK1/CCNB2 4 BP GO:0043031 negative regulation of macrophage activation 4/1096 16/18670 0.01218 0.05146 0.0349 CD200/FCGR2B/PTPRC/CST7 4 BP GO:0043174 nucleoside salvage 4/1096 16/18670 0.01218 0.05146 0.0349 HPRT1/DCK/TYMP/TK2 4 BP GO:0051081 nuclear envelope disassembly 4/1096 16/18670 0.01218 0.05146 0.0349 PRKCB/CCNB1/PLK1/CCNB2 4 BP GO:0061548 ganglion development 4/1096 16/18670 0.01218 0.05146 0.0349 SEMA3A/SIX1/UNC5C/NRP2 4 BP GO:0071380 cellular response to prostaglandin E stimulus 4/1096 16/18670 0.01218 0.05146 0.0349 P2RY6/ADCY6/PTGER2/SFRP1 4 BP GO:0072189 ureter development 4/1096 16/18670 0.01218 0.05146 0.0349 SIX1/GATA3/BMP4/NFIA 4 BP GO:0006024 glycosaminoglycan biosynthetic process 13/1096 110/18670 0.01229 0.05186 0.03517 UST/XYLT1/ANGPT1/IL1B/SDC1/NFKB1/B4GALT2/CHST3/ABCC5/GPC5/HEXA/UGDH/HYAL1 13 BP GO:0006939 smooth muscle contraction 13/1096 110/18670 0.01229 0.05186 0.03517 ADA/SULF1/ADORA1/PTAFR/MYH11/CD38/RGS2/ACTA2/F2R/PRKG1/KCNB2/CTTN/CHRM3 13 BP GO:0031669 cellular response to nutrient levels 23/1096 237/18670 0.01249 0.05263 0.0357 FOXO1/LPL/PCK1/ICAM1/NAMPT/POSTN/XBP1/MAPK3/SIK1/DAP/HSPA5/PDK2/COL1A1/GABARAPL1/GAS6/PIM1/EHMT2/WDR45/SFRP1/NPRL3/INHBB/IL15/JUN 23 BP GO:1901657 glycosyl compound metabolic process 16/1096 147/18670 0.01261 0.05313 0.03603 ADA/AKR1B1/AMPD3/HPRT1/AKR7A2/DCK/AKR1B10/AHCY/NME3/GUK1/IMPDH1/IMPDH2/TYMP/TK2/AHCYL2/NAGA 16 BP GO:0008016 regulation of heart contraction 24/1096 251/18670 0.0129 0.05419 0.03676 TGFB2/SEMA3A/ADA/HBEGF/THRA/BIN1/STC1/FXYD1/DES/ADORA3/ADORA1/PLN/GCH1/MYL2/RGS2/CASQ2/ASPH/MYH7/CAV3/MYL3/AKAP9/ATP2A1/SNTA1/HDAC4 24 BP GO:0009066 aspartate family amino acid metabolic process 8/1096 54/18670 0.01291 0.05419 0.03676 ASS1/GOT2/ASPA/GOT1/AHCY/CRYM/SDS/AHCYL2 8 BP GO:0032655 regulation of interleukin-12 production 8/1096 54/18670 0.01291 0.05419 0.03676 PLCB1/IRF1/CD40/SLAMF1/CCR7/NFKB1/IRF8/TLR2 8 BP GO:1904645 response to amyloid-beta 8/1096 54/18670 0.01291 0.05419 0.03676 ICAM1/FCGR2B/NAMPT/BCL2L2/ITGA4/DNM1/CASP4/LGMN 8 BP GO:0030010 establishment of cell polarity 15/1096 135/18670 0.01292 0.05419 0.03676 UST/GSN/GATA3/PTK2B/GPSM2/CCR7/PAK1/CDH5/KANK1/MAP4/AMOTL2/PLK1/SPRY1/TCF15/AMOT 15 BP GO:0060359 response to ammonium ion 15/1096 135/18670 0.01292 0.05419 0.03676 PLCB1/CXCR4/GABRB1/ADA/PTK2B/MAPK3/ASS1/GNA11/PTAFR/GOT2/HSPA5/ID1/CCNA2/CASP7/CHRM3 15 BP GO:0046578 regulation of Ras protein signal transduction 23/1096 238/18670 0.01308 0.05482 0.03718 SH2B2/TGFB2/MAPRE2/RASGRP1/ARHGEF10/PSD3/AUTS2/DNMBP/ARHGDIB/TIMP2/TNFAIP1/KANK1/RAPGEF1/F2R/DLC1/APOE/NGF/ABR/ARHGEF5/VAV1/SPRY1/COL3A1/PSD4 23 BP GO:0007492 endoderm development 10/1096 76/18670 0.01312 0.05486 0.03721 ITGAV/SMAD3/ITGA4/PAF1/BMP4/ITGA5/HDAC1/BMPR1A/ITGB2/MMP15 10 BP GO:0046785 microtubule polymerization 10/1096 76/18670 0.01312 0.05486 0.03721 MECP2/ARL2/PAK1/MAPRE3/CDH5/CAV3/AKAP9/CAMSAP2/STMN2/TUBGCP4 10 BP GO:0060411 cardiac septum morphogenesis 10/1096 76/18670 0.01312 0.05486 0.03721 TGFBR3/PARVA/TGFB2/FZD2/SEMA3C/BMP4/DHRS3/BMPR1A/NRP2/SMAD6 10 BP GO:0031128 developmental induction 6/1096 34/18670 0.0132 0.05502 0.03732 SIX1/AR/FGFR1/BMP4/HOXA11/SPRY1 6 BP GO:0043094 cellular metabolic compound salvage 6/1096 34/18670 0.0132 0.05502 0.03732 ADA/AMPD3/HPRT1/DCK/TYMP/TK2 6 BP GO:0048566 embryonic digestive tract development 6/1096 34/18670 0.0132 0.05502 0.03732 RARRES2/TGFB2/ADA/TCF7/CXCL8/PDGFRA 6 BP GO:0071402 cellular response to lipoprotein particle stimulus 6/1096 34/18670 0.0132 0.05502 0.03732 LPL/NPC1/MYD88/ABCG1/APOE/ITGB2 6 BP GO:0033157 regulation of intracellular protein transport 22/1096 225/18670 0.01322 0.05502 0.03732 RAC2/HUWE1/ANGPT1/ADIPOQ/ANK3/LCP1/TCF7L2/IL1B/SMAD3/ZIC1/PAK1/RAB29/TM9SF4/PKIG/HCLS1/GAS6/PINK1/BMP4/UBE2J1/ITGB2/PPM1A/TENM1 22 BP GO:0006940 regulation of smooth muscle contraction 9/1096 65/18670 0.01324 0.05502 0.03732 ADA/ADORA1/PTAFR/RGS2/F2R/PRKG1/KCNB2/CTTN/CHRM3 9 BP GO:0032729 positive regulation of interferon-gamma production 9/1096 65/18670 0.01324 0.05502 0.03732 RASGRP1/CD226/IL1B/CD2/IL27RA/CD14/CCR2/PTPN22/IRF8 9 BP GO:0051187 cofactor catabolic process 9/1096 65/18670 0.01324 0.05502 0.03732 HBB/PXDN/GPX3/BLVRA/GPX1/AHCY/LPO/PRDX2/HBE1 9 BP GO:0060389 pathway-restricted SMAD protein phosphorylation 9/1096 65/18670 0.01324 0.05502 0.03732 TGFBR3/TGFB2/PIN1/LDLRAD4/BMP4/GDF10/BMPR1A/SMAD6/INHBB 9 BP GO:0007179 transforming growth factor beta receptor signaling pathway 20/1096 199/18670 0.01335 0.05541 0.03758 TGFBR3/TGFB2/SMAD3/HSPA5/CDH5/SMAD1/ID1/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/HTRA1/GDF10/BMPR1A/PPM1A/COL3A1/SMAD6/ADAMTSL2/JUN 20 BP GO:0035107 appendage morphogenesis 16/1096 148/18670 0.0134 0.05553 0.03766 ZBTB16/HOXA10/TGFB2/ATRX/PITX1/ASPH/FGFR1/SEMA3C/BMP4/B9D1/HDAC1/BMPR1A/PLXNA2/TWIST1/OSR2/HOXA11 16 BP GO:0035108 limb morphogenesis 16/1096 148/18670 0.0134 0.05553 0.03766 ZBTB16/HOXA10/TGFB2/ATRX/PITX1/ASPH/FGFR1/SEMA3C/BMP4/B9D1/HDAC1/BMPR1A/PLXNA2/TWIST1/OSR2/HOXA11 16 BP GO:0006195 purine nucleotide catabolic process 7/1096 44/18670 0.01344 0.05561 0.03772 PDE1A/ADA/AMPD3/HPRT1/GPX1/PDE9A/NUDT3 7 BP GO:1902667 regulation of axon guidance 7/1096 44/18670 0.01344 0.05561 0.03772 SEMA5A/VEGFA/SEMA3E/SEMA3A/SEMA3C/SEMA4F/CXCL12 7 BP GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 5/1096 25/18670 0.01373 0.05657 0.03837 TNFAIP3/LY96/LILRA2/SASH1/PRDX2 5 BP GO:0034110 regulation of homotypic cell-cell adhesion 5/1096 25/18670 0.01373 0.05657 0.03837 SERPINE2/CCL5/ANK3/PDPN/PRKG1 5 BP GO:0060571 morphogenesis of an epithelial fold 5/1096 25/18670 0.01373 0.05657 0.03837 EGFR/SULF1/AR/HIF1A/BMP4 5 BP GO:0072202 cell differentiation involved in metanephros development 5/1096 25/18670 0.01373 0.05657 0.03837 WWTR1/ADIPOQ/BMP4/STAT1/LAMB2 5 BP GO:0072677 eosinophil migration 5/1096 25/18670 0.01373 0.05657 0.03837 CCL5/ADAM8/CCL13/CCL2/CCL7 5 BP GO:1900101 regulation of endoplasmic reticulum unfolded protein response 5/1096 25/18670 0.01373 0.05657 0.03837 XBP1/HSPA5/ATF6/PTPN2/WFS1 5 BP GO:2000177 regulation of neural precursor cell proliferation 11/1096 88/18670 0.01378 0.05674 0.03848 FOXO1/VEGFA/CDON/BTG2/CX3CR1/GATA2/RAPGEF1/SMARCD3/HIF1A/CDH2/SPINT2 11 BP GO:0051101 regulation of DNA binding 14/1096 124/18670 0.01403 0.05773 0.03916 GATA3/CPNE1/ID3/NFKBIA/GZMA/ID1/ID4/PLAUR/NGF/CTNNBIP1/TWIST1/FOXC1/TFAP4/JUN 14 BP GO:0003279 cardiac septum development 13/1096 112/18670 0.01416 0.05817 0.03946 TGFBR3/PARVA/TGFB2/GATA3/FZD2/MYH10/SEMA3C/BMP4/DHRS3/BMPR1A/NRP2/NPRL3/SMAD6 13 BP GO:0014902 myotube differentiation 13/1096 112/18670 0.01416 0.05817 0.03946 IL4R/CDON/SIX1/XBP1/SIK1/CD53/CAV3/ACTA1/GPX1/ADAM12/CXCL10/HDAC4/TNFSF14 13 BP GO:0043030 regulation of macrophage activation 8/1096 55/18670 0.01436 0.05891 0.03995 IL4R/CD200/FCGR2B/CTSC/PTPRC/MFHAS1/CST7/LBP 8 BP GO:0045620 negative regulation of lymphocyte differentiation 8/1096 55/18670 0.01436 0.05891 0.03995 RUNX3/IL4R/IRF1/BMP4/LAG3/SFRP1/PTPN2/PRDX2 8 BP GO:1905207 regulation of cardiocyte differentiation 9/1096 66/18670 0.01456 0.0597 0.04049 TGFB2/EGFR/PAK1/RGS2/CAV3/SEMA3C/PIN1/BMP4/FZD7 9 BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 21/1096 214/18670 0.01468 0.06014 0.04079 PTK2B/NUPR1/RGN/RNF144A/CTSC/TRIB2/PLK2/CAV3/PINK1/LAMP3/GPX1/NFE2L1/CAMLG/UBE2J1/USP7/APOE/RAD23B/PLK1/USP5/HERPUD1/GLMN 21 BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 18/1096 175/18670 0.0147 0.0602 0.04083 ITGAV/TAP1/KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/TAPBP/DCTN2/LGMN/NCF2/IKBKG 18 BP GO:0051924 regulation of calcium ion transport 24/1096 254/18670 0.01474 0.06031 0.0409 CXCR4/CCL5/CORO1A/P2RY6/LILRB2/ICAM1/BIN1/PTK2B/STC1/PLN/PTPN6/RGN/CASQ2/LILRA2/PLCG2/CAV3/F2R/THY1/HOMER3/ATP2A1/CXCL10/CXCL12/CCL2/WFS1 24 BP GO:0061053 somite development 11/1096 89/18670 0.01491 0.06093 0.04133 SIX1/MEOX1/SMAD3/SEMA3C/LFNG/BMPR1A/PLXNA2/FOXC1/SFRP1/COBL/TCF15 11 BP GO:0097306 cellular response to alcohol 11/1096 89/18670 0.01491 0.06093 0.04133 P2RY6/DAG1/ADCY6/EFNA5/MAP4K1/CDK4/NFE2L1/PTGER2/SFRP1/CCL7/ADCY1 11 BP GO:0001974 blood vessel remodeling 7/1096 45/18670 0.01513 0.06118 0.04149 AXL/TGM2/NOL3/CCR2/SEMA3C/ABR/FOXC1 7 BP GO:0002820 negative regulation of adaptive immune response 7/1096 45/18670 0.01513 0.06118 0.04149 IL4R/IL7R/FCGR2B/PTPN6/IL27RA/PTPRC/PARP3 7 BP GO:0032570 response to progesterone 7/1096 45/18670 0.01513 0.06118 0.04149 GABRB1/TGFB2/CSN1S1/CD38/BAD/TLR2/PTGER2 7 BP GO:0045581 negative regulation of T cell differentiation 7/1096 45/18670 0.01513 0.06118 0.04149 RUNX3/IL4R/IRF1/BMP4/LAG3/PTPN2/PRDX2 7 BP GO:0071827 plasma lipoprotein particle organization 7/1096 45/18670 0.01513 0.06118 0.04149 LPL/LIPC/ABCG1/APOC1/PLA2G7/APOE/AGTR1 7 BP GO:1902743 regulation of lamellipodium organization 7/1096 45/18670 0.01513 0.06118 0.04149 RAC2/AUTS2/CD44/PDPN/KANK1/NCKAP1/HDAC4 7 BP GO:0032735 positive regulation of interleukin-12 production 6/1096 35/18670 0.01516 0.06118 0.04149 PLCB1/IRF1/CD40/CCR7/IRF8/TLR2 6 BP GO:0042455 ribonucleoside biosynthetic process 6/1096 35/18670 0.01516 0.06118 0.04149 ADA/HPRT1/NME3/GUK1/IMPDH1/IMPDH2 6 BP GO:0043200 response to amino acid 13/1096 113/18670 0.01517 0.06118 0.04149 EGFR/SIX1/PCK1/ICAM1/XBP1/ASS1/COL1A1/CDO1/BAD/GLRB/PDGFRA/COL3A1/COL4A1 13 BP GO:0021783 preganglionic parasympathetic fiber development 4/1096 17/18670 0.0152 0.06118 0.04149 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0031643 positive regulation of myelination 4/1096 17/18670 0.0152 0.06118 0.04149 TNFRSF1B/ITGAX/DAG1/CST7 4 BP GO:0033599 regulation of mammary gland epithelial cell proliferation 4/1096 17/18670 0.0152 0.06118 0.04149 GATA3/CCND1/HOXA5/GPX1 4 BP GO:0034433 steroid esterification 4/1096 17/18670 0.0152 0.06118 0.04149 ABCG1/APOC1/APOE/AGTR1 4 BP GO:0034434 sterol esterification 4/1096 17/18670 0.0152 0.06118 0.04149 ABCG1/APOC1/APOE/AGTR1 4 BP GO:0034435 cholesterol esterification 4/1096 17/18670 0.0152 0.06118 0.04149 ABCG1/APOC1/APOE/AGTR1 4 BP GO:0051818 disruption of cells of other organism involved in symbiotic interaction 4/1096 17/18670 0.0152 0.06118 0.04149 CXCL6/PF4/BAD/ELANE 4 BP GO:0061298 retina vasculature development in camera-type eye 4/1096 17/18670 0.0152 0.06118 0.04149 HIF1A/LRP5/PDGFRA/COL4A1 4 BP GO:0070242 thymocyte apoptotic process 4/1096 17/18670 0.0152 0.06118 0.04149 ADAM8/ADA/HIF1A/BMP4 4 BP GO:0090185 negative regulation of kidney development 4/1096 17/18670 0.0152 0.06118 0.04149 ADIPOQ/GATA3/BMP4/STAT1 4 BP GO:1905331 negative regulation of morphogenesis of an epithelium 4/1096 17/18670 0.0152 0.06118 0.04149 GATA3/SULF1/BMP4/STAT1 4 BP GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 4/1096 17/18670 0.0152 0.06118 0.04149 GSN/SMAD3/PLAUR/TFAP4 4 BP GO:0006575 cellular modified amino acid metabolic process 20/1096 202/18670 0.01552 0.0624 0.04232 HPGDS/GATA3/GPX4/CRAT/GCH1/ASS1/GOT2/PLSCR1/ALDH5A1/CRTAP/GSTA4/GPX1/NFE2L1/DIO3/AHCY/CKMT2/GSTT1/CRYM/MTHFD2/AHCYL2 20 BP GO:0014743 regulation of muscle hypertrophy 10/1096 78/18670 0.01558 0.06257 0.04244 FOXO1/TNFRSF1B/SMAD3/PAK1/RGS2/CAV3/PIN1/IGFBP5/PDE9A/JARID2 10 BP GO:0070664 negative regulation of leukocyte proliferation 10/1096 78/18670 0.01558 0.06257 0.04244 TNFAIP3/LILRB2/FCGR2B/PTPN6/DLG5/BMP4/CD86/INPP5D/IL2RA/GLMN 10 BP GO:0000768 syncytium formation by plasma membrane fusion 8/1096 56/18670 0.01591 0.06378 0.04326 IL4R/CDON/TCTA/CD53/CAV3/ADAM12/CXCL10/TNFSF14 8 BP GO:0032615 interleukin-12 production 8/1096 56/18670 0.01591 0.06378 0.04326 PLCB1/IRF1/CD40/SLAMF1/CCR7/NFKB1/IRF8/TLR2 8 BP GO:0140253 cell-cell fusion 8/1096 56/18670 0.01591 0.06378 0.04326 IL4R/CDON/TCTA/CD53/CAV3/ADAM12/CXCL10/TNFSF14 8 BP GO:0010594 regulation of endothelial cell migration 22/1096 229/18670 0.01594 0.06385 0.04331 CXCL13/MECP2/ANGPT1/SEMA5A/VEGFA/EMP2/AKT3/GATA3/PTK2B/CD40/STC1/HSPB1/FGFR1/SASH1/PLK2/GATA2/HIF1A/BMP4/APOE/LGMN/NRP2/ANGPT2 22 BP GO:0048706 embryonic skeletal system development 14/1096 126/18670 0.01597 0.06388 0.04333 XYLT1/SIX1/PCGF2/SMAD3/SULF1/RBP4/COL1A1/HOXA5/BMP4/TWIST1/OSR2/PDGFRA/HOXA11/HYAL1 14 BP GO:1903391 regulation of adherens junction organization 9/1096 67/18670 0.01597 0.06388 0.04333 VEGFA/EPHA3/MAPRE2/SMAD3/THY1/DLC1/EFNA5/SFRP1/DUSP3 9 BP GO:0010959 regulation of metal ion transport 34/1096 394/18670 0.016 0.06393 0.04336 SERPINE2/CXCR4/CCL5/CORO1A/P2RY6/ANK3/LILRB2/ICAM1/BIN1/PTK2B/STC1/FXYD1/ADORA1/NEDD4L/PLN/SIK1/PTPN6/RGN/CASQ2/LILRA2/KCNAB1/PLCG2/CAV3/AKAP9/F2R/THY1/HOMER3/ATP2A1/SNTA1/CXCL10/CXCL12/CCL2/FHL1/WFS1 34 BP GO:0007611 learning or memory 24/1096 256/18670 0.01608 0.06422 0.04356 PLCB1/EGR2/MECP2/EGFR/LILRB2/THRA/SHANK2/BTG2/KCNAB1/INSR/CX3CR1/B4GALT2/PLK2/HIF1A/NRGN/ITGA5/NTF3/TLR2/APOE/NGF/LGMN/NPTX2/JUN/ADCY1 24 BP GO:1903035 negative regulation of response to wounding 11/1096 90/18670 0.01612 0.06427 0.04359 SPP1/SERPINE2/SMAD3/TFPI/INPP5F/PLAUR/PRKG1/APOE/SERPINE1/APCS/PDGFRA 11 BP GO:0003171 atrioventricular valve development 5/1096 26/18670 0.01619 0.06427 0.04359 TGFB2/OLFM1/BMPR1A/TWIST1/SMAD6 5 BP GO:0032800 receptor biosynthetic process 5/1096 26/18670 0.01619 0.06427 0.04359 ITGAV/ADIPOQ/HOXA5/HIF1A/HDAC1 5 BP GO:0032957 inositol trisphosphate metabolic process 5/1096 26/18670 0.01619 0.06427 0.04359 PLCB1/P2RY6/PTK2B/PTAFR/PLCG2 5 BP GO:0045992 negative regulation of embryonic development 5/1096 26/18670 0.01619 0.06427 0.04359 GATA3/SULF1/BMP4/FZD7/LFNG 5 BP GO:0048843 negative regulation of axon extension involved in axon guidance 5/1096 26/18670 0.01619 0.06427 0.04359 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F 5 BP GO:0060914 heart formation 5/1096 26/18670 0.01619 0.06427 0.04359 SIX1/SMARCD3/BMP4/PIM1/BMPR1A 5 BP GO:0071377 cellular response to glucagon stimulus 5/1096 26/18670 0.01619 0.06427 0.04359 PCK1/ADCY9/ASS1/ADCY6/ADCY1 5 BP GO:0071711 basement membrane organization 5/1096 26/18670 0.01619 0.06427 0.04359 PXDN/DAG1/LAMB2/SPINT2/COL4A1 5 BP GO:0045446 endothelial cell differentiation 13/1096 114/18670 0.01623 0.06433 0.04363 CXCR4/VEGFA/ICAM1/STC1/IL1B/S1PR1/CDH5/PDPN/ID1/RAPGEF1/BMP4/GPX1/PECAM1 13 BP GO:0060349 bone morphogenesis 13/1096 114/18670 0.01623 0.06433 0.04363 STC1/SFRP4/ALPL/COL1A1/BMP4/LRP5/DHRS3/TWIST1/FOXC1/CARM1/FGFR3/OSR2/HOXA11 13 BP GO:0033135 regulation of peptidyl-serine phosphorylation 15/1096 139/18670 0.01654 0.06546 0.0444 ANGPT1/VEGFA/EGFR/NTRK3/PAK1/CD44/HCLS1/GAS6/INPP5F/AKAP9/PINK1/NTF3/DDIT4/TENM1/PFN2 15 BP GO:0035304 regulation of protein dephosphorylation 15/1096 139/18670 0.01654 0.06546 0.0444 MAGI2/LILRB2/ADORA1/RGN/PTPRC/CDH5/MFHAS1/MGAT5/PIN1/PINK1/DLC1/PPP1R2/NCKAP1L/PPP1R1A/CAMTA1 15 BP GO:0044843 cell cycle G1/S phase transition 27/1096 298/18670 0.01687 0.0667 0.04524 PLCB1/EGFR/CDK10/BTG2/CCND2/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/BCAT1/PLK2/PAF1/ID4/CCNA2/CDK4/CCNB1/PIM2/GSPT1/CNOT4/CARM1/CCL2/FHL1/PRIM2/CUL4A/HYAL1/CDC6 27 BP GO:0031110 regulation of microtubule polymerization or depolymerization 10/1096 79/18670 0.01693 0.06691 0.04538 MECP2/ARL2/MAPRE2/PAK1/MAPRE3/CDH5/CAV3/AKAP9/CAMSAP2/STMN2 10 BP GO:0035270 endocrine system development 14/1096 127/18670 0.01701 0.06718 0.04557 FOXO1/SIX1/THRA/GATA3/SMAD3/MAPK3/PITX1/INSR/GATA2/HOXA5/BMP4/BAD/BMPR1A/PDGFRA 14 BP GO:0071695 anatomical structure maturation 17/1096 165/18670 0.01714 0.06766 0.04589 XYLT1/MECP2/TGFB2/GATA3/PTK2B/DAG1/S1PR1/XBP1/CDC25B/CDH5/CX3CR1/HOXA5/HIF1A/CCNB1/RERE/FGFR3/TRIM58 17 BP GO:0001505 regulation of neurotransmitter levels 31/1096 354/18670 0.01722 0.06782 0.046 MAOA/HBB/STXBP1/GCHFR/STX11/ICAM1/PRKCB/PTK2B/IL1B/SMAD3/GCH1/RGN/ASS1/RGS2/SLC29A1/INSR/CX3CR1/HDC/SYT17/ALDH5A1/MOXD1/UNC13B/NQO1/TLR2/SNCG/RIMS3/ITGB2/SDS/PFN2/SLC18A2/ADCY1 31 BP GO:0002755 MyD88-dependent toll-like receptor signaling pathway 6/1096 36/18670 0.01731 0.06782 0.046 IRF1/LY96/CD14/MYD88/TLR2/IRF7 6 BP GO:0003091 renal water homeostasis 6/1096 36/18670 0.01731 0.06782 0.046 AKR1B1/ADCY9/ADCY6/AQP1/WFS1/ADCY1 6 BP GO:0006882 cellular zinc ion homeostasis 6/1096 36/18670 0.01731 0.06782 0.046 LCK/S100A9/SLC39A8/MT1G/SLC39A14/SLC39A7 6 BP GO:0010573 vascular endothelial growth factor production 6/1096 36/18670 0.01731 0.06782 0.046 IL1B/SULF1/ADAMTS3/CCR2/HIF1A/C3AR1 6 BP GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 6/1096 36/18670 0.01731 0.06782 0.046 VEGFA/PRKCB/IL1B/HIF1A/ITGA5/FLT1 6 BP GO:0035137 hindlimb morphogenesis 6/1096 36/18670 0.01731 0.06782 0.046 ZBTB16/PITX1/BMP4/BMPR1A/TWIST1/OSR2 6 BP GO:0046627 negative regulation of insulin receptor signaling pathway 6/1096 36/18670 0.01731 0.06782 0.046 ENPP1/PRKCB/IL1B/KANK1/PTPN2/PTPRE 6 BP GO:0090218 positive regulation of lipid kinase activity 6/1096 36/18670 0.01731 0.06782 0.046 PTK2B/CCR7/EEF1A2/FGFR3/PDGFRA/FLT1 6 BP GO:0034976 response to endoplasmic reticulum stress 26/1096 285/18670 0.01735 0.06782 0.046 CREB3L2/TNFRSF10B/FCGR2B/NUPR1/EEF2/XBP1/CXCL8/CCND1/HSPA5/GFPT1/CASP4/RNF103/ATF6/ATP2A1/NFE2L1/KDELR3/UBE4B/UBE2J1/THBS4/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1/JUN 26 BP GO:0006023 aminoglycan biosynthetic process 13/1096 115/18670 0.01735 0.06782 0.046 UST/XYLT1/ANGPT1/IL1B/SDC1/NFKB1/B4GALT2/CHST3/ABCC5/GPC5/HEXA/UGDH/HYAL1 13 BP GO:0032612 interleukin-1 production 13/1096 115/18670 0.01735 0.06782 0.046 TNFAIP3/LPL/AIM2/IL1B/SMAD3/CCR7/HSPB1/LILRA2/CX3CR1/GAS6/S100A13/F2R/NLRP3 13 BP GO:0032963 collagen metabolic process 13/1096 115/18670 0.01735 0.06782 0.046 MFAP4/CTSD/ADAMTS2/ADAMTS3/CTSL/ID1/COL1A1/TRAM2/HIF1A/F2R/GOT1/BMP4/MMP15 13 BP GO:0046660 female sex differentiation 13/1096 115/18670 0.01735 0.06782 0.046 VEGFA/AXL/ICAM1/NUPR1/RBP4/HSPA5/INSR/LFNG/FOXC1/SFRP1/PDGFRA/TYRO3/INHBB 13 BP GO:0014909 smooth muscle cell migration 11/1096 91/18670 0.0174 0.0679 0.04606 PARVA/CCL5/P2RY6/ADIPOQ/POSTN/PAK1/IGFBP5/PRKG1/SERPINE1/HDAC4/BMPR1A 11 BP GO:0045639 positive regulation of myeloid cell differentiation 11/1096 91/18670 0.0174 0.0679 0.04606 HCLS1/GATA2/HOXA5/HIF1A/NCKAP1L/PF4/STAT1/CTNNBIP1/INPP5D/TRIM58/JUN 11 BP GO:0032091 negative regulation of protein binding 12/1096 103/18670 0.0175 0.06801 0.04613 ADIPOQ/SLPI/MAPK3/HSPA5/ITGA4/ID1/PIN1/PIM2/CTNNBIP1/PTPRF/CARM1/TFIP11 12 BP GO:0034620 cellular response to unfolded protein 15/1096 140/18670 0.01756 0.06801 0.04613 CREB3L2/DAXX/XBP1/CXCL8/CCND1/HSPA5/GFPT1/ATF6/KDELR3/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1 15 BP GO:0001787 natural killer cell proliferation 3/1096 10/18670 0.01773 0.06801 0.04613 PTPN22/ELF4/IL15 3 BP GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 3/1096 10/18670 0.01773 0.06801 0.04613 ICAM1/ITGAL/HLA-DMB 3 BP GO:0002713 negative regulation of B cell mediated immunity 3/1096 10/18670 0.01773 0.06801 0.04613 FCGR2B/PTPN6/PARP3 3 BP GO:0002890 negative regulation of immunoglobulin mediated immune response 3/1096 10/18670 0.01773 0.06801 0.04613 FCGR2B/PTPN6/PARP3 3 BP GO:0003149 membranous septum morphogenesis 3/1096 10/18670 0.01773 0.06801 0.04613 TGFB2/FZD2/BMP4 3 BP GO:0003183 mitral valve morphogenesis 3/1096 10/18670 0.01773 0.06801 0.04613 BMPR1A/TWIST1/SMAD6 3 BP GO:0006171 cAMP biosynthetic process 3/1096 10/18670 0.01773 0.06801 0.04613 ADCY9/ADCY6/ADCY1 3 BP GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation 3/1096 10/18670 0.01773 0.06801 0.04613 SGCA/DAG1/HDAC4 3 BP GO:0014894 response to denervation involved in regulation of muscle adaptation 3/1096 10/18670 0.01773 0.06801 0.04613 SGCA/DAG1/HDAC4 3 BP GO:0030647 aminoglycoside antibiotic metabolic process 3/1096 10/18670 0.01773 0.06801 0.04613 AKR1B1/AKR7A2/AKR1B10 3 BP GO:0034350 regulation of glial cell apoptotic process 3/1096 10/18670 0.01773 0.06801 0.04613 GAS6/PRKCH/CCL2 3 BP GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 3/1096 10/18670 0.01773 0.06801 0.04613 DDR2/COL1A1/COL4A1 3 BP GO:0044557 relaxation of smooth muscle 3/1096 10/18670 0.01773 0.06801 0.04613 ADORA1/RGS2/PRKG1 3 BP GO:0044803 multi-organism membrane organization 3/1096 10/18670 0.01773 0.06801 0.04613 CXCR4/CCR5/GAS6 3 BP GO:0048340 paraxial mesoderm morphogenesis 3/1096 10/18670 0.01773 0.06801 0.04613 SMAD3/BMPR1A/FOXC1 3 BP GO:0060068 vagina development 3/1096 10/18670 0.01773 0.06801 0.04613 AXL/RBP4/TYRO3 3 BP GO:0060513 prostatic bud formation 3/1096 10/18670 0.01773 0.06801 0.04613 SULF1/AR/BMP4 3 BP GO:0060600 dichotomous subdivision of an epithelial terminal unit 3/1096 10/18670 0.01773 0.06801 0.04613 SEMA3A/CTSH/SEMA3C 3 BP GO:0070391 response to lipoteichoic acid 3/1096 10/18670 0.01773 0.06801 0.04613 CD14/TLR2/LBP 3 BP GO:0070942 neutrophil mediated cytotoxicity 3/1096 10/18670 0.01773 0.06801 0.04613 DNASE1L3/CXCL6/ELANE 3 BP GO:0071104 response to interleukin-9 3/1096 10/18670 0.01773 0.06801 0.04613 IL2RG/STAT1/IL9R 3 BP GO:0071223 cellular response to lipoteichoic acid 3/1096 10/18670 0.01773 0.06801 0.04613 CD14/TLR2/LBP 3 BP GO:1903862 positive regulation of oxidative phosphorylation 3/1096 10/18670 0.01773 0.06801 0.04613 NUPR1/PINK1/CCNB1 3 BP GO:2000109 regulation of macrophage apoptotic process 3/1096 10/18670 0.01773 0.06801 0.04613 CCL5/CCR5/IRF7 3 BP GO:0051017 actin filament bundle assembly 16/1096 153/18670 0.0179 0.06857 0.04651 LCP1/ARHGEF10/PTK2B/ACTN1/PLEK/SMAD3/PAK1/S1PR1/FAM171A1/ID1/TNFAIP1/DLC1/MYO1B/ARHGEF5/SFRP1/PFN2 16 BP GO:0090316 positive regulation of intracellular protein transport 16/1096 153/18670 0.0179 0.06857 0.04651 RAC2/HUWE1/ANK3/TCF7L2/IL1B/SMAD3/ZIC1/PAK1/RAB29/TM9SF4/HCLS1/GAS6/PINK1/ITGB2/PPM1A/TENM1 16 BP GO:0042445 hormone metabolic process 22/1096 232/18670 0.01826 0.06989 0.0474 SPP1/CPA3/MECP2/ADH1B/GATA3/TCF7L2/IL1B/AKR1B1/RBP4/ADH1A/ADH1C/NFKB1/FGFR1/PNPLA4/HIF1A/DIO3/AKR1B10/DHRS3/HSD11B2/NGF/CRYM/PDGFRA 22 BP GO:0021782 glial cell development 13/1096 116/18670 0.01853 0.07082 0.04803 GSN/EGFR/NDRG1/NTRK3/ARHGEF10/DAG1/IL1B/MXRA8/ASPA/ID4/TSPAN2/TLR2/LAMB2 13 BP GO:0021987 cerebral cortex development 13/1096 116/18670 0.01853 0.07082 0.04803 PLCB1/CDON/EGFR/SEMA3A/HIF1A/TACC2/BAD/BCL2A1/CDH2/NRP2/GNG12/BNIP3/COL3A1 13 BP GO:0007252 I-kappaB phosphorylation 4/1096 18/18670 0.01865 0.07096 0.04813 CX3CR1/ERC1/TLR2/IKBKE 4 BP GO:0045780 positive regulation of bone resorption 4/1096 18/18670 0.01865 0.07096 0.04813 SPP1/ADAM8/EGFR/TFRC 4 BP GO:0046459 short-chain fatty acid metabolic process 4/1096 18/18670 0.01865 0.07096 0.04813 PCK1/ACADS/ALDH5A1/PCK2 4 BP GO:0046852 positive regulation of bone remodeling 4/1096 18/18670 0.01865 0.07096 0.04813 SPP1/ADAM8/EGFR/TFRC 4 BP GO:0051023 regulation of immunoglobulin secretion 4/1096 18/18670 0.01865 0.07096 0.04813 CD40/RBP4/XBP1/TNFRSF4 4 BP GO:0150079 negative regulation of neuroinflammatory response 4/1096 18/18670 0.01865 0.07096 0.04813 TNFRSF1B/CD200/PTPRC/CST7 4 BP GO:1905276 regulation of epithelial tube formation 4/1096 18/18670 0.01865 0.07096 0.04813 SIX1/GATA3/FZD2/SFRP1 4 BP GO:0035710 CD4-positive, alpha-beta T cell activation 11/1096 92/18670 0.01875 0.07127 0.04834 RUNX3/IL4R/RELB/GATA3/GPR183/BATF/CD83/NCKAP1L/SATB1/CD86/NLRP3 11 BP GO:0045671 negative regulation of osteoclast differentiation 5/1096 27/18670 0.01894 0.07168 0.04862 TCTA/LILRB4/LILRB3/INPP5D/SFRP1 5 BP GO:0045932 negative regulation of muscle contraction 5/1096 27/18670 0.01894 0.07168 0.04862 BIN1/ADORA1/TNNT1/RGS2/PRKG1 5 BP GO:0060384 innervation 5/1096 27/18670 0.01894 0.07168 0.04862 SERPINE2/SEMA3A/SULF1/ITGA4/UNC13B 5 BP GO:1905208 negative regulation of cardiocyte differentiation 5/1096 27/18670 0.01894 0.07168 0.04862 EGFR/PAK1/RGS2/CAV3/FZD7 5 BP GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 7/1096 47/18670 0.01896 0.07168 0.04862 RUNX3/IL4R/GATA3/CD83/NCKAP1L/CD86/NLRP3 7 BP GO:0045646 regulation of erythrocyte differentiation 7/1096 47/18670 0.01896 0.07168 0.04862 GATA2/HOXA5/HIF1A/NCKAP1L/STAT1/INPP5D/TRIM58 7 BP GO:0048806 genitalia development 7/1096 47/18670 0.01896 0.07168 0.04862 AXL/TCF7/RBP4/AR/ASB1/PDGFRA/TYRO3 7 BP GO:0070849 response to epidermal growth factor 7/1096 47/18670 0.01896 0.07168 0.04862 EGFR/MAPK3/ID1/COL1A1/SKAP1/FOXC1/DUSP3 7 BP GO:0007219 Notch signaling pathway 19/1096 193/18670 0.019 0.07182 0.04871 TSPAN5/TGFB2/SORBS2/EGFR/TIMP4/POSTN/PLN/NFKBIA/CFD/GATA2/GOT1/LFNG/ZMIZ1/STAT1/SUSD5/SPEN/PTP4A3/FOXC1/IL2RA 19 BP GO:0042698 ovulation cycle 9/1096 69/18670 0.01909 0.07198 0.04882 GABRB1/TGFB2/EGFR/AXL/TIMP4/PAM/HSPA5/PDGFRA/TYRO3 9 BP GO:0086003 cardiac muscle cell contraction 9/1096 69/18670 0.01909 0.07198 0.04882 BIN1/STC1/ADORA1/NEDD4L/PLN/KCNJ8/CAV3/ATP2A1/SNTA1 9 BP GO:2000243 positive regulation of reproductive process 9/1096 69/18670 0.01909 0.07198 0.04882 PLCB1/SEMA3A/CDC25B/PTAFR/INSR/AR/LFNG/HDAC4/INHBB 9 BP GO:0043534 blood vessel endothelial cell migration 18/1096 180/18670 0.0191 0.07198 0.04882 MECP2/ANGPT1/VEGFA/EMP2/AKT3/PTK2B/CD40/HSPB1/ID1/EGR3/FGFR1/PLK2/GATA2/HIF1A/GPX1/APOE/ANGPT2/AMOT 18 BP GO:0072330 monocarboxylic acid biosynthetic process 30/1096 343/18670 0.01917 0.0722 0.04897 UST/ZBTB20/LPL/LTC4S/PTGS1/HPGDS/ADIPOQ/CH25H/NUPR1/IL1B/PFKM/GPX4/ADIPOR2/HK2/XBP1/RGN/TECR/LIPC/INSR/SLC27A2/APOC1/HIF1A/ACOX2/HDAC4/DDIT4/SDS/NUP210/PTGDS/ALOX5/ALDOA 30 BP GO:0035904 aorta development 8/1096 58/18670 0.01939 0.07283 0.0494 TGFB2/SIX1/MYH10/BMPR1A/LOXL1/NPRL3/COL3A1/SMAD6 8 BP GO:0051058 negative regulation of small GTPase mediated signal transduction 8/1096 58/18670 0.01939 0.07283 0.0494 ARHGAP12/TGFB2/TIMP2/TNFAIP1/KANK1/RAPGEF1/DLC1/SPRY1 8 BP GO:0055081 anion homeostasis 8/1096 58/18670 0.01939 0.07283 0.0494 CA12/ENPP1/XBP1/ADORA1/SFRP4/ABCG1/GOT1/APOE 8 BP GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 8/1096 58/18670 0.01939 0.07283 0.0494 TNFAIP3/TNFRSF10B/ICAM1/TNFSF10/GPX1/TIMP3/SERPINE1/SFRP1 8 BP GO:0014037 Schwann cell differentiation 6/1096 37/18670 0.01967 0.07364 0.04995 EGR2/NDRG1/NTRK3/ARHGEF10/DAG1/LAMB2 6 BP GO:0043114 regulation of vascular permeability 6/1096 37/18670 0.01967 0.07364 0.04995 ANGPT1/VEGFA/CDH5/CTNNBIP1/ABR/PTP4A3 6 BP GO:0045730 respiratory burst 6/1096 37/18670 0.01967 0.07364 0.04995 RAC2/INSR/LBP/NCF2/PRDX2/CD52 6 BP GO:0071276 cellular response to cadmium ion 6/1096 37/18670 0.01967 0.07364 0.04995 GSN/EGFR/DAXX/MAPK3/MT1G/JUN 6 BP GO:1905314 semi-lunar valve development 6/1096 37/18670 0.01967 0.07364 0.04995 TNFRSF1B/TGFB2/GATA3/BMP4/TWIST1/SMAD6 6 BP GO:0010822 positive regulation of mitochondrion organization 13/1096 117/18670 0.01977 0.0739 0.05013 RAC2/HUWE1/GZMB/HK2/TNFSF10/HIF1A/PINK1/PLAUR/ZNF205/BAD/MLLT11/BNIP3/PPP3CC 13 BP GO:0051153 regulation of striated muscle cell differentiation 13/1096 117/18670 0.01977 0.0739 0.05013 IL4R/PAK1/XBP1/SIK1/RGS2/CD53/CAV3/PIN1/BMP4/FZD7/CXCL10/HDAC4/TNFSF14 13 BP GO:0006898 receptor-mediated endocytosis 28/1096 316/18670 0.0198 0.07399 0.05019 MAGI2/ANGPT1/HBB/VEGFA/FNBP1L/FCGR2B/SFRP4/CXCL8/CD14/ITGA4/INSR/PLCG2/DNM1/APOC1/INPP5F/CAV3/NTF3/IGKC/HIP1/USP46/APOE/SERPINE1/IGLV6-57/CTTN/SNAP91/TFRC/IGLC1/ITGB2 28 BP GO:0002821 positive regulation of adaptive immune response 12/1096 105/18670 0.0201 0.07505 0.05091 CD226/ADA/GATA3/CD40/IL1B/TP53BP1/IL27RA/PTPRC/SKAP1/CCR2/NLRP3/TFRC 12 BP GO:0035249 synaptic transmission, glutamatergic 11/1096 93/18670 0.02017 0.07524 0.05103 SERPINE2/STXBP1/EGFR/PTK2B/SHANK2/ADORA1/SLC1A4/CCR2/UNC13B/CDH2/CCL2 11 BP GO:1901184 regulation of ERBB signaling pathway 11/1096 93/18670 0.02017 0.07524 0.05103 TGFA/EGFR/HBEGF/ADORA1/BTC/PLAUR/HIP1/LGMN/DUSP3/PTPN2/SPRY1 11 BP GO:0001701 in utero embryonic development 32/1096 373/18670 0.02047 0.07627 0.05173 HOPX/ANGPT1/VEGFA/EGFR/ADA/GATA3/PCGF2/SMAD3/ADCY9/MYH10/ADAMTS3/AR/FGFR1/GATA2/HIF1A/B9D1/CCNB1/ZMIZ1/PHLDA2/BMPR1A/C6/TWIST1/MAFF/FOXC1/SPINT2/PDGFRA/CUL4A/ST14/RXRA/STIL/AMOT/CCNB2 32 BP GO:0051966 regulation of synaptic transmission, glutamatergic 9/1096 70/18670 0.02081 0.07749 0.05256 SERPINE2/STXBP1/EGFR/PTK2B/SHANK2/ADORA1/CCR2/CDH2/CCL2 9 BP GO:0031056 regulation of histone modification 15/1096 143/18670 0.02089 0.07775 0.05274 MECP2/VEGFA/GATA3/ATRX/IL1B/AUTS2/MAPK3/GATA2/PAF1/PINK1/CCNB1/ZNHIT1/TADA3/JARID2/TWIST1 15 BP GO:0001774 microglial cell activation 7/1096 48/18670 0.0211 0.07823 0.05306 NAMPT/CTSC/PTPRC/CST7/TLR2/ITGB2/JUN 7 BP GO:0002269 leukocyte activation involved in inflammatory response 7/1096 48/18670 0.0211 0.07823 0.05306 NAMPT/CTSC/PTPRC/CST7/TLR2/ITGB2/JUN 7 BP GO:0032648 regulation of interferon-beta production 7/1096 48/18670 0.0211 0.07823 0.05306 ZBTB20/RELB/IRF1/NMI/TLR2/IRF7/TRAF3 7 BP GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 7/1096 48/18670 0.0211 0.07823 0.05306 TGFA/EGFR/HBEGF/BTC/DUSP3/PTPN2/SPRY1 7 BP GO:0045912 negative regulation of carbohydrate metabolic process 7/1096 48/18670 0.0211 0.07823 0.05306 ADIPOQ/ENPP1/NUPR1/PLEK/SIK1/HDAC4/DDIT4 7 BP GO:0045933 positive regulation of muscle contraction 7/1096 48/18670 0.0211 0.07823 0.05306 ADA/PTAFR/RGS2/F2R/ATP2A1/CTTN/CHRM3 7 BP GO:0019884 antigen processing and presentation of exogenous antigen 18/1096 182/18670 0.02111 0.07823 0.05306 ITGAV/TAP1/KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/TAPBP/DCTN2/LGMN/NCF2/IKBKG 18 BP GO:0038095 Fc-epsilon receptor signaling pathway 17/1096 169/18670 0.02119 0.07844 0.0532 ITK/MS4A2/PAK1/MAPK3/GAB2/NFKB1/LCP2/PLCG2/PAK2/IGKC/MAPK10/IGLV6-57/VAV1/IGLC1/IKBKG/JUN/LAT 17 BP GO:0045843 negative regulation of striated muscle tissue development 8/1096 59/18670 0.02131 0.07877 0.05342 PAK1/RBP4/RGS2/CAV3/BMP4/FZD7/JARID2/TWIST1 8 BP GO:0061077 chaperone-mediated protein folding 8/1096 59/18670 0.02131 0.07877 0.05342 DNAJB5/BAG1/HSPB1/HSPA5/PEX19/TRAP1/CRTAP/HSPB6 8 BP GO:0097755 positive regulation of blood vessel diameter 8/1096 59/18670 0.02131 0.07877 0.05342 EGFR/ADORA1/GCH1/PTAFR/RGS2/GPX1/PRKG1/APOE 8 BP GO:0055117 regulation of cardiac muscle contraction 10/1096 82/18670 0.0215 0.07935 0.05382 BIN1/STC1/ADORA1/PLN/RGS2/CASQ2/CAV3/AKAP9/ATP2A1/HDAC4 10 BP GO:0097581 lamellipodium organization 10/1096 82/18670 0.0215 0.07935 0.05382 RAC2/AUTS2/S1PR1/CD44/PDPN/ABLIM1/KANK1/NCKAP1/HDAC4/CTTN 10 BP GO:0001958 endochondral ossification 5/1096 28/18670 0.02197 0.08067 0.05472 ALPL/COL1A1/BMP4/FOXC1/FGFR3 5 BP GO:0009074 aromatic amino acid family catabolic process 5/1096 28/18670 0.02197 0.08067 0.05472 FAH/HPD/HDC/PCBD1/QDPR 5 BP GO:0032770 positive regulation of monooxygenase activity 5/1096 28/18670 0.02197 0.08067 0.05472 PTK2B/IL1B/GCH1/HIF1A/APOE 5 BP GO:0035116 embryonic hindlimb morphogenesis 5/1096 28/18670 0.02197 0.08067 0.05472 ZBTB16/PITX1/BMP4/TWIST1/OSR2 5 BP GO:0036075 replacement ossification 5/1096 28/18670 0.02197 0.08067 0.05472 ALPL/COL1A1/BMP4/FOXC1/FGFR3 5 BP GO:0036296 response to increased oxygen levels 5/1096 28/18670 0.02197 0.08067 0.05472 FOXO1/COL1A1/CDK4/BNIP3/ATP6V0D1 5 BP GO:0052312 modulation of transcription in other organism involved in symbiotic interaction 5/1096 28/18670 0.02197 0.08067 0.05472 CCL5/NTRK3/HDAC1/TFAP4/JUN 5 BP GO:1902668 negative regulation of axon guidance 5/1096 28/18670 0.02197 0.08067 0.05472 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F 5 BP GO:0071322 cellular response to carbohydrate stimulus 15/1096 144/18670 0.0221 0.0811 0.055 ZBTB20/PCK1/ICAM1/PRKCB/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/SLC2A5/BAD/MAPK13/PCK2 15 BP GO:0003298 physiological muscle hypertrophy 6/1096 38/18670 0.02223 0.0812 0.05508 SORBS2/PAK1/RGS2/CAV3/PIN1/PDLIM5 6 BP GO:0003301 physiological cardiac muscle hypertrophy 6/1096 38/18670 0.02223 0.0812 0.05508 SORBS2/PAK1/RGS2/CAV3/PIN1/PDLIM5 6 BP GO:0015804 neutral amino acid transport 6/1096 38/18670 0.02223 0.0812 0.05508 NFKBIE/SLC1A4/RGS2/SLC7A8/SLC7A5/NFE2L1 6 BP GO:0016572 histone phosphorylation 6/1096 38/18670 0.02223 0.0812 0.05508 PRKCB/IL1B/MAPK3/CCNA2/CCNB1/TWIST1 6 BP GO:0055069 zinc ion homeostasis 6/1096 38/18670 0.02223 0.0812 0.05508 LCK/S100A9/SLC39A8/MT1G/SLC39A14/SLC39A7 6 BP GO:0061049 cell growth involved in cardiac muscle cell development 6/1096 38/18670 0.02223 0.0812 0.05508 SORBS2/PAK1/RGS2/CAV3/PIN1/PDLIM5 6 BP GO:1904037 positive regulation of epithelial cell apoptotic process 6/1096 38/18670 0.02223 0.0812 0.05508 GSN/CD40/SFRP4/ITGA4/BAD/CCL2 6 BP GO:0043271 negative regulation of ion transport 16/1096 157/18670 0.02228 0.0813 0.05514 SERPINE2/ANK3/LILRB2/ICAM1/BIN1/PTK2B/STC1/ADORA1/NEDD4L/PLN/SFRP4/RGS2/CASQ2/KCNAB1/CAV3/TWIST1 16 BP GO:0061572 actin filament bundle organization 16/1096 157/18670 0.02228 0.0813 0.05514 LCP1/ARHGEF10/PTK2B/ACTN1/PLEK/SMAD3/PAK1/S1PR1/FAM171A1/ID1/TNFAIP1/DLC1/MYO1B/ARHGEF5/SFRP1/PFN2 16 BP GO:0007173 epidermal growth factor receptor signaling pathway 13/1096 119/18670 0.02242 0.08155 0.05531 TGFA/EGFR/HBEGF/PTK2B/ADORA1/BTC/PLAUR/EFEMP1/HIP1/CAMLG/DUSP3/PTPN2/SPRY1 13 BP GO:0002076 osteoblast development 4/1096 19/18670 0.02256 0.08155 0.05531 SMAD3/PTHLH/LRP5/HDAC4 4 BP GO:0002544 chronic inflammatory response 4/1096 19/18670 0.02256 0.08155 0.05531 TNFAIP3/CCL5/CXCL13/AHCY 4 BP GO:0003159 morphogenesis of an endothelium 4/1096 19/18670 0.02256 0.08155 0.05531 CXCR4/ITGAX/BMP4/CXCL10 4 BP GO:0006534 cysteine metabolic process 4/1096 19/18670 0.02256 0.08155 0.05531 CDO1/AHCY/TST/AHCYL2 4 BP GO:0010544 negative regulation of platelet activation 4/1096 19/18670 0.02256 0.08155 0.05531 SERPINE2/PRKG1/APOE/PDGFRA 4 BP GO:0010888 negative regulation of lipid storage 4/1096 19/18670 0.02256 0.08155 0.05531 ITGAV/NFKBIA/ABCG1/PTPN2 4 BP GO:0015669 gas transport 4/1096 19/18670 0.02256 0.08155 0.05531 HBB/MB/AQP1/HBE1 4 BP GO:0046597 negative regulation of viral entry into host cell 4/1096 19/18670 0.02256 0.08155 0.05531 FCN1/GSN/MID2/APCS 4 BP GO:0048486 parasympathetic nervous system development 4/1096 19/18670 0.02256 0.08155 0.05531 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0061154 endothelial tube morphogenesis 4/1096 19/18670 0.02256 0.08155 0.05531 CXCR4/ITGAX/BMP4/CXCL10 4 BP GO:0071731 response to nitric oxide 4/1096 19/18670 0.02256 0.08155 0.05531 FOXO1/CCR7/CCNA2/AQP1 4 BP GO:0072074 kidney mesenchyme development 4/1096 19/18670 0.02256 0.08155 0.05531 SIX1/BMP4/BASP1/STAT1 4 BP GO:2000696 regulation of epithelial cell differentiation involved in kidney development 4/1096 19/18670 0.02256 0.08155 0.05531 WWTR1/ADIPOQ/GATA3/STAT1 4 BP GO:0043647 inositol phosphate metabolic process 9/1096 71/18670 0.02263 0.08172 0.05543 PLCB1/P2RY6/PTK2B/PLEK/PTAFR/PLCG2/MINPP1/INPP5D/NUDT3 9 BP GO:0051057 positive regulation of small GTPase mediated signal transduction 9/1096 71/18670 0.02263 0.08172 0.05543 CDON/MAPRE2/RASGRP1/AUTS2/RAPGEF1/F2R/NGF/VAV1/COL3A1 9 BP GO:0006970 response to osmotic stress 10/1096 83/18670 0.02321 0.08236 0.05586 RELB/EGFR/PTK2B/AKR1B1/AQP9/EFHD1/AQP1/BAD/MAPK10/MAPK13 10 BP GO:0042100 B cell proliferation 11/1096 95/18670 0.02327 0.08236 0.05586 IL7R/ADA/CD40/FCGR2B/GPR183/CD38/PTPRC/TNFRSF4/NCKAP1L/INPP5D/TFRC 11 BP GO:0002517 T cell tolerance induction 3/1096 11/18670 0.02334 0.08236 0.05586 PHLPP1/LILRB2/IL2RA 3 BP GO:0002887 negative regulation of myeloid leukocyte mediated immunity 3/1096 11/18670 0.02334 0.08236 0.05586 FCGR2B/CCR2/ABR 3 BP GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 3/1096 11/18670 0.02334 0.08236 0.05586 FCGR2B/PTPN6/PTPRC 3 BP GO:0003174 mitral valve development 3/1096 11/18670 0.02334 0.08236 0.05586 BMPR1A/TWIST1/SMAD6 3 BP GO:0006183 GTP biosynthetic process 3/1096 11/18670 0.02334 0.08236 0.05586 NME3/IMPDH1/IMPDH2 3 BP GO:0008655 pyrimidine-containing compound salvage 3/1096 11/18670 0.02334 0.08236 0.05586 DCK/TYMP/TK2 3 BP GO:0009125 nucleoside monophosphate catabolic process 3/1096 11/18670 0.02334 0.08236 0.05586 AMPD3/HPRT1/NUDT3 3 BP GO:0009950 dorsal/ventral axis specification 3/1096 11/18670 0.02334 0.08236 0.05586 BMPR1A/SFRP1/SMAD6 3 BP GO:0014870 response to muscle inactivity 3/1096 11/18670 0.02334 0.08236 0.05586 SGCA/DAG1/HDAC4 3 BP GO:0015791 polyol transport 3/1096 11/18670 0.02334 0.08236 0.05586 SLC5A3/AQP9/AQP1 3 BP GO:0019042 viral latency 3/1096 11/18670 0.02334 0.08236 0.05586 HMGA1/PSIP1/IRF7 3 BP GO:0019371 cyclooxygenase pathway 3/1096 11/18670 0.02334 0.08236 0.05586 PTGS1/HPGDS/PTGDS 3 BP GO:0021604 cranial nerve structural organization 3/1096 11/18670 0.02334 0.08236 0.05586 EGR2/SEMA3A/NRP2 3 BP GO:0032490 detection of molecule of bacterial origin 3/1096 11/18670 0.02334 0.08236 0.05586 LY96/TLR2/LBP 3 BP GO:0033327 Leydig cell differentiation 3/1096 11/18670 0.02334 0.08236 0.05586 CCND1/AR/PDGFRA 3 BP GO:0034115 negative regulation of heterotypic cell-cell adhesion 3/1096 11/18670 0.02334 0.08236 0.05586 ADIPOQ/IL1RN/MAPK7 3 BP GO:0035457 cellular response to interferon-alpha 3/1096 11/18670 0.02334 0.08236 0.05586 AXL/GATA3/GAS6 3 BP GO:0035747 natural killer cell chemotaxis 3/1096 11/18670 0.02334 0.08236 0.05586 CCL5/CCL2/CCL7 3 BP GO:0043097 pyrimidine nucleoside salvage 3/1096 11/18670 0.02334 0.08236 0.05586 DCK/TYMP/TK2 3 BP GO:0045628 regulation of T-helper 2 cell differentiation 3/1096 11/18670 0.02334 0.08236 0.05586 IL4R/CD86/NLRP3 3 BP GO:0046439 L-cysteine metabolic process 3/1096 11/18670 0.02334 0.08236 0.05586 CDO1/AHCY/AHCYL2 3 BP GO:0051024 positive regulation of immunoglobulin secretion 3/1096 11/18670 0.02334 0.08236 0.05586 RBP4/XBP1/TNFRSF4 3 BP GO:0051561 positive regulation of mitochondrial calcium ion concentration 3/1096 11/18670 0.02334 0.08236 0.05586 TGM2/ATP2A1/BNIP3 3 BP GO:0060433 bronchus development 3/1096 11/18670 0.02334 0.08236 0.05586 HOXA5/BMP4/ADAMTSL2 3 BP GO:0060439 trachea morphogenesis 3/1096 11/18670 0.02334 0.08236 0.05586 MAPK3/HOXA5/BMP4 3 BP GO:0070106 interleukin-27-mediated signaling pathway 3/1096 11/18670 0.02334 0.08236 0.05586 IL27RA/STAT1/CRLF1 3 BP GO:0070587 regulation of cell-cell adhesion involved in gastrulation 3/1096 11/18670 0.02334 0.08236 0.05586 ADIPOQ/IL1RN/MAPK7 3 BP GO:0070757 interleukin-35-mediated signaling pathway 3/1096 11/18670 0.02334 0.08236 0.05586 IL27RA/STAT4/STAT1 3 BP GO:0072584 caveolin-mediated endocytosis 3/1096 11/18670 0.02334 0.08236 0.05586 MAPK3/NEDD4L/CAV3 3 BP GO:1901894 regulation of calcium-transporting ATPase activity 3/1096 11/18670 0.02334 0.08236 0.05586 PLN/RGN/ATP2A1 3 BP GO:1904321 response to forskolin 3/1096 11/18670 0.02334 0.08236 0.05586 ADCY6/EFNA5/ADCY1 3 BP GO:1904322 cellular response to forskolin 3/1096 11/18670 0.02334 0.08236 0.05586 ADCY6/EFNA5/ADCY1 3 BP GO:2000392 regulation of lamellipodium morphogenesis 3/1096 11/18670 0.02334 0.08236 0.05586 CD44/PDPN/KANK1 3 BP GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/1096 11/18670 0.02334 0.08236 0.05586 GSN/SMAD3/TFAP4 3 BP GO:0048635 negative regulation of muscle organ development 8/1096 60/18670 0.02337 0.08236 0.05586 PAK1/RBP4/RGS2/CAV3/BMP4/FZD7/JARID2/TWIST1 8 BP GO:0051893 regulation of focal adhesion assembly 8/1096 60/18670 0.02337 0.08236 0.05586 VEGFA/EPHA3/SMAD3/THY1/DLC1/EFNA5/SFRP1/DUSP3 8 BP GO:0090109 regulation of cell-substrate junction assembly 8/1096 60/18670 0.02337 0.08236 0.05586 VEGFA/EPHA3/SMAD3/THY1/DLC1/EFNA5/SFRP1/DUSP3 8 BP GO:0002704 negative regulation of leukocyte mediated immunity 7/1096 49/18670 0.02341 0.08241 0.05589 IL7R/FCGR2B/PTPN6/PTPRC/CCR2/PARP3/ABR 7 BP GO:0048546 digestive tract morphogenesis 7/1096 49/18670 0.02341 0.08241 0.05589 EGFR/TCF7/SMAD3/HIF1A/BMP4/SFRP1/PDGFRA 7 BP GO:0060402 calcium ion transport into cytosol 16/1096 158/18670 0.0235 0.08265 0.05606 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0000082 G1/S transition of mitotic cell cycle 25/1096 279/18670 0.02355 0.08279 0.05615 PLCB1/EGFR/CDK10/BTG2/CCND2/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/BCAT1/PLK2/ID4/CDK4/CCNB1/PIM2/GSPT1/CNOT4/CARM1/CCL2/FHL1/PRIM2/CUL4A/HYAL1/CDC6 25 BP GO:0002698 negative regulation of immune effector process 13/1096 120/18670 0.02385 0.08377 0.05682 IL4R/ANGPT1/IL7R/TGFB2/FCGR2B/PTPN6/PTPRC/CCR2/PARP3/PCBP2/HTRA1/ABR/IL2RA 13 BP GO:0045665 negative regulation of neuron differentiation 21/1096 225/18670 0.02425 0.08514 0.05775 SPP1/SEMA5A/SEMA3E/SEMA3A/ZNF365/ID3/CD38/RAB29/ID1/ADCY6/PLK2/INPP5F/KANK1/SEMA3C/THY1/SEMA4F/ID4/DIO3/APOE/STMN2/CARM1 21 BP GO:0046883 regulation of hormone secretion 24/1096 266/18670 0.02429 0.08523 0.05781 SPP1/CCL5/ARL2/EGFR/ADIPOQ/TCF7L2/IL1B/RBP4/ADORA1/NMB/CD38/ICA1/HADH/OXCT1/FGFR1/HIF1A/EFNA5/LRP5/BAD/SLC25A4/AGTR1/SFRP1/INHBB/NNAT 24 BP GO:0038034 signal transduction in absence of ligand 9/1096 72/18670 0.02456 0.08608 0.05839 ITGAV/IL1B/BCL2L2/FGFR1/MAPK7/PF4/BAD/BCL2A1/PRDX2 9 BP GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 9/1096 72/18670 0.02456 0.08608 0.05839 ITGAV/IL1B/BCL2L2/FGFR1/MAPK7/PF4/BAD/BCL2A1/PRDX2 9 BP GO:0009914 hormone transport 28/1096 322/18670 0.02463 0.08623 0.05849 SPP1/CCL5/ARL2/EGFR/ADIPOQ/IL1RN/GATA3/TCF7L2/IL1B/RBP4/ADORA1/NMB/CD38/ICA1/HADH/OXCT1/FGFR1/HIF1A/LTBP4/EFNA5/LRP5/BAD/SLC25A4/AGTR1/CRYM/SFRP1/INHBB/NNAT 28 BP GO:0009895 negative regulation of catabolic process 27/1096 308/18670 0.02464 0.08623 0.05849 SERPINE2/EGFR/TIMP4/CIRBP/NUPR1/IL1B/NAMPT/SMAD3/ADORA1/NELL1/DAP/RGN/NPC1/MYD88/TIMP2/APOC1/PTPN22/PIN1/PINK1/LAMP3/PHB/TIMP3/CAMLG/UBE2J1/USP7/HDAC4/DDIT4 27 BP GO:0021543 pallium development 17/1096 172/18670 0.02467 0.08628 0.05852 PLCB1/EZH1/CDON/EGFR/SEMA3A/BTG2/HIF1A/ID4/TACC2/HDAC1/BAD/BCL2A1/CDH2/NRP2/GNG12/BNIP3/COL3A1 17 BP GO:1904892 regulation of STAT cascade 15/1096 146/18670 0.02468 0.08628 0.05852 CCL5/IL7R/PTK2B/CD40/AKR1B1/PTPRC/HCLS1/INPP5F/MGAT5/F2R/PECAM1/PTPN2/FGFR3/CRLF1/IL15 15 BP GO:1990823 response to leukemia inhibitory factor 11/1096 96/18670 0.02494 0.087 0.05901 SPOCK2/KAT6B/ICAM1/HK2/XBP1/SYNGR1/JARID2/PTP4A3/TFRC/NRP2/PCOLCE 11 BP GO:1990830 cellular response to leukemia inhibitory factor 11/1096 96/18670 0.02494 0.087 0.05901 SPOCK2/KAT6B/ICAM1/HK2/XBP1/SYNGR1/JARID2/PTP4A3/TFRC/NRP2/PCOLCE 11 BP GO:0002718 regulation of cytokine production involved in immune response 10/1096 84/18670 0.02501 0.087 0.05901 TNFRSF1B/ANGPT1/TGFB2/CD226/GATA3/IL1B/MAPK3/TRIL/CCR2/NLRP3 10 BP GO:0014910 regulation of smooth muscle cell migration 10/1096 84/18670 0.02501 0.087 0.05901 CCL5/P2RY6/ADIPOQ/POSTN/PAK1/IGFBP5/PRKG1/SERPINE1/HDAC4/BMPR1A 10 BP GO:1905897 regulation of response to endoplasmic reticulum stress 10/1096 84/18670 0.02501 0.087 0.05901 FCGR2B/NUPR1/XBP1/HSPA5/ATF6/NFE2L1/UBE2J1/PTPN2/WFS1/HERPUD1 10 BP GO:0030204 chondroitin sulfate metabolic process 6/1096 39/18670 0.02501 0.087 0.05901 XYLT1/SPOCK2/CHST3/HEXA/UGDH/HYAL1 6 BP GO:0042417 dopamine metabolic process 6/1096 39/18670 0.02501 0.087 0.05901 MAOA/TGFB2/GCH1/HPRT1/MOXD1/ITGB2 6 BP GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/1096 39/18670 0.02501 0.087 0.05901 TNFAIP3/TNFRSF10B/ICAM1/TNFSF10/GPX1/SERPINE1 6 BP GO:0016052 carbohydrate catabolic process 19/1096 199/18670 0.02525 0.08754 0.05937 ZBTB20/NUPR1/PFKM/HK2/GK/MAN2B2/PYGM/PYGB/INSR/HIF1A/LRP5/BAD/PGD/HDAC4/DDIT4/AOAH/NUP210/ALDOA/NAGA 19 BP GO:0035966 response to topologically incorrect protein 19/1096 199/18670 0.02525 0.08754 0.05937 CREB3L2/HSPB2/DAXX/XBP1/DNAJB5/HSPB1/CXCL8/CCND1/HSPA5/GFPT1/ATF6/KDELR3/THBS4/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1 19 BP GO:0014044 Schwann cell development 5/1096 29/18670 0.0253 0.08754 0.05937 NDRG1/NTRK3/ARHGEF10/DAG1/LAMB2 5 BP GO:0031116 positive regulation of microtubule polymerization 5/1096 29/18670 0.0253 0.08754 0.05937 MECP2/ARL2/PAK1/CAV3/AKAP9 5 BP GO:0033032 regulation of myeloid cell apoptotic process 5/1096 29/18670 0.0253 0.08754 0.05937 CCL5/ADIPOQ/THRA/CCR5/IRF7 5 BP GO:0050855 regulation of B cell receptor signaling pathway 5/1096 29/18670 0.0253 0.08754 0.05937 PRKCB/FCGR2B/PTPN22/PRKCH/LPXN 5 BP GO:1900027 regulation of ruffle assembly 5/1096 29/18670 0.0253 0.08754 0.05937 ICAM1/SH3YL1/KANK1/COBL/PFN2 5 BP GO:1900181 negative regulation of protein localization to nucleus 5/1096 29/18670 0.0253 0.08754 0.05937 ANGPT1/DCLK1/LILRB4/MFHAS1/PKIG 5 BP GO:1901017 negative regulation of potassium ion transmembrane transporter activity 5/1096 29/18670 0.0253 0.08754 0.05937 ANK3/NEDD4L/CASQ2/KCNAB1/CAV3 5 BP GO:0003170 heart valve development 8/1096 61/18670 0.02557 0.08818 0.05981 TNFRSF1B/TGFB2/GATA3/OLFM1/BMP4/BMPR1A/TWIST1/SMAD6 8 BP GO:0007405 neuroblast proliferation 8/1096 61/18670 0.02557 0.08818 0.05981 SOX5/VEGFA/EML1/CX3CR1/FGFR1/SMARCD3/HIF1A/ID4 8 BP GO:0032233 positive regulation of actin filament bundle assembly 8/1096 61/18670 0.02557 0.08818 0.05981 ARHGEF10/PLEK/SMAD3/PAK1/ID1/ARHGEF5/SFRP1/PFN2 8 BP GO:0042733 embryonic digit morphogenesis 8/1096 61/18670 0.02557 0.08818 0.05981 ZBTB16/BMP4/B9D1/HDAC1/BMPR1A/TWIST1/OSR2/HOXA11 8 BP GO:0050701 interleukin-1 secretion 8/1096 61/18670 0.02557 0.08818 0.05981 TNFAIP3/LPL/AIM2/CCR7/LILRA2/GAS6/S100A13/NLRP3 8 BP GO:0022900 electron transport chain 18/1096 186/18670 0.02563 0.08836 0.05993 MECP2/LOXL2/AKR1B1/COX7A1/ASPH/ALDH5A1/PINK1/AKR7A2/NQO1/CCNB1/COX6A2/DHRS3/QDPR/NDUFB7/NDUFV1/NCF2/UQCRC1/ETFB 18 BP GO:0032608 interferon-beta production 7/1096 50/18670 0.02589 0.0892 0.0605 ZBTB20/RELB/IRF1/NMI/TLR2/IRF7/TRAF3 7 BP GO:0016525 negative regulation of angiogenesis 17/1096 173/18670 0.02592 0.08923 0.06052 MECP2/TGFB2/SEMA3E/THBS2/SULF1/CX3CR1/PLK2/CCR2/HOXA5/PF4/STAT1/SERPINE1/CXCL10/THBS4/FOXC1/ANGPT2/AMOT 17 BP GO:0010212 response to ionizing radiation 15/1096 147/18670 0.02605 0.08964 0.0608 CRYAB/ICAM1/GATA3/NAMPT/TP53BP1/CCND1/HSPA5/PTPRC/ERCC1/GPX1/CXCL10/KAT5/SFRP1/EEF1D/CCL7 15 BP GO:0021915 neural tube development 16/1096 160/18670 0.02607 0.08964 0.0608 TGFB2/TCF7/FZD2/RALA/SEMA3C/HIF1A/BMP4/DLC1/PLXNA2/TWIST1/SFRP1/COBL/SPINT2/ST14/STIL/GLMN 16 BP GO:0050890 cognition 26/1096 296/18670 0.02648 0.09099 0.06171 PLCB1/EGR2/MECP2/EGFR/LILRB2/THRA/SHANK2/ADORA1/BTG2/SLC1A4/KCNAB1/INSR/CX3CR1/B4GALT2/PLK2/HIF1A/NRGN/ITGA5/NTF3/TLR2/APOE/NGF/LGMN/NPTX2/JUN/ADCY1 26 BP GO:0006801 superoxide metabolic process 9/1096 73/18670 0.02661 0.09124 0.06188 EGFR/GCH1/RGN/FBLN5/NQO1/FANCC/ITGB2/NCF2/PRDX2 9 BP GO:0032945 negative regulation of mononuclear cell proliferation 9/1096 73/18670 0.02661 0.09124 0.06188 LILRB2/FCGR2B/PTPN6/DLG5/BMP4/CD86/INPP5D/IL2RA/GLMN 9 BP GO:0046128 purine ribonucleoside metabolic process 9/1096 73/18670 0.02661 0.09124 0.06188 ADA/AMPD3/HPRT1/AHCY/NME3/GUK1/IMPDH1/IMPDH2/AHCYL2 9 BP GO:0050672 negative regulation of lymphocyte proliferation 9/1096 73/18670 0.02661 0.09124 0.06188 LILRB2/FCGR2B/PTPN6/DLG5/BMP4/CD86/INPP5D/IL2RA/GLMN 9 BP GO:0120162 positive regulation of cold-induced thermogenesis 11/1096 97/18670 0.02669 0.09129 0.06192 IL4R/CXCR4/FABP4/VEGFA/ADIPOQ/THRA/ADIPOR2/HADH/UCP2/CCR2/G0S2 11 BP GO:1902882 regulation of response to oxidative stress 11/1096 97/18670 0.02669 0.09129 0.06192 HSPB1/GCH1/RGN/FBLN5/NOL3/TRAP1/HIF1A/PINK1/ACOX2/GPX1/MAPK7 11 BP GO:1901343 negative regulation of vasculature development 18/1096 187/18670 0.02687 0.09129 0.06192 MECP2/TGFB2/SEMA3E/THBS2/SULF1/CX3CR1/PLK2/CCR2/HOXA5/BMP4/PF4/STAT1/SERPINE1/CXCL10/THBS4/FOXC1/ANGPT2/AMOT 18 BP GO:1905475 regulation of protein localization to membrane 18/1096 187/18670 0.02687 0.09129 0.06192 GZMB/GSN/EPHA3/EGFR/ANK3/DAG1/PAK1/SPTBN1/AR/BAD/GPC5/GBP1/PRKCH/CSK/CDH2/ITGB2/PPP3CC/LYPLA1 18 BP GO:0019079 viral genome replication 13/1096 122/18670 0.02689 0.09129 0.06192 CCL5/HTATSF1/SLPI/CXCL8/RAB29/PLSCR1/ISG20/GAS6/CXCR6/NFIA/PCBP2/CCL2/VAPA 13 BP GO:0019730 antimicrobial humoral response 13/1096 122/18670 0.02689 0.09129 0.06192 RARRES2/CXCL13/CCL13/SLPI/CXCL8/S100A9/CXCL1/CXCL6/PF4/CXCL3/CXCL10/GNLY/ELANE 13 BP GO:0002577 regulation of antigen processing and presentation 4/1096 20/18670 0.02692 0.09129 0.06192 LILRB2/FCGR2B/CCR7/HLA-DOB 4 BP GO:0006071 glycerol metabolic process 4/1096 20/18670 0.02692 0.09129 0.06192 PCK1/GK/GOT1/PCK2 4 BP GO:0010560 positive regulation of glycoprotein biosynthetic process 4/1096 20/18670 0.02692 0.09129 0.06192 PLCB1/TCF7L2/CCR7/IL15 4 BP GO:0010592 positive regulation of lamellipodium assembly 4/1096 20/18670 0.02692 0.09129 0.06192 RAC2/AUTS2/NCKAP1/HDAC4 4 BP GO:0016137 glycoside metabolic process 4/1096 20/18670 0.02692 0.09129 0.06192 AKR1B1/AKR7A2/AKR1B10/NAGA 4 BP GO:0032495 response to muramyl dipeptide 4/1096 20/18670 0.02692 0.09129 0.06192 TNFAIP3/NFKBIA/LDOC1/PTPN22 4 BP GO:0032816 positive regulation of natural killer cell activation 4/1096 20/18670 0.02692 0.09129 0.06192 AXL/RASGRP1/GAS6/IL15 4 BP GO:0051767 nitric-oxide synthase biosynthetic process 4/1096 20/18670 0.02692 0.09129 0.06192 NAMPT/TLR2/STAT1/CCL2 4 BP GO:0051769 regulation of nitric-oxide synthase biosynthetic process 4/1096 20/18670 0.02692 0.09129 0.06192 NAMPT/TLR2/STAT1/CCL2 4 BP GO:0097062 dendritic spine maintenance 4/1096 20/18670 0.02692 0.09129 0.06192 FCGR2B/INSR/APOE/CTTN 4 BP GO:1903599 positive regulation of autophagy of mitochondrion 4/1096 20/18670 0.02692 0.09129 0.06192 HK2/HIF1A/PINK1/BNIP3 4 BP GO:1905523 positive regulation of macrophage migration 4/1096 20/18670 0.02692 0.09129 0.06192 CCL5/RARRES2/MAPK3/C3AR1 4 BP GO:0045732 positive regulation of protein catabolic process 20/1096 214/18670 0.02706 0.09171 0.0622 FOXO1/TNFAIP3/TNFRSF1B/ADAM8/PTK2B/NUPR1/IL1B/NEDD4L/RGN/RNF144A/CTSC/TRIB2/PLK2/CAV3/AREL1/APOE/PLK1/USP5/HERPUD1/PTTG1IP 20 BP GO:0007585 respiratory gaseous exchange 8/1096 62/18670 0.0279 0.09433 0.06398 FTO/MECP2/CSF2RB/SLC5A3/ADORA1/TNNC1/HOXA5/TCF15 8 BP GO:0010676 positive regulation of cellular carbohydrate metabolic process 8/1096 62/18670 0.0279 0.09433 0.06398 FOXO1/P2RY6/RGN/PTAFR/INSR/DYRK2/BAD/PTPN2 8 BP GO:0010830 regulation of myotube differentiation 8/1096 62/18670 0.0279 0.09433 0.06398 IL4R/XBP1/SIK1/CD53/CAV3/CXCL10/HDAC4/TNFSF14 8 BP GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 8/1096 62/18670 0.0279 0.09433 0.06398 TGFB2/PIN1/LDLRAD4/BMP4/GDF10/BMPR1A/SMAD6/INHBB 8 BP GO:0002369 T cell cytokine production 6/1096 40/18670 0.02801 0.09449 0.06409 TNFRSF1B/GATA3/IL1B/CCR2/KDELR1/NLRP3 6 BP GO:0009187 cyclic nucleotide metabolic process 6/1096 40/18670 0.02801 0.09449 0.06409 PDE1A/ADCY9/PTHLH/ADCY6/PDE9A/ADCY1 6 BP GO:0009395 phospholipid catabolic process 6/1096 40/18670 0.02801 0.09449 0.06409 PNPLA6/LIPC/PLCG2/APOC1/INPP5F/PLA2G15 6 BP GO:0071470 cellular response to osmotic stress 6/1096 40/18670 0.02801 0.09449 0.06409 RELB/AKR1B1/EFHD1/AQP1/BAD/MAPK10 6 BP GO:0051604 protein maturation 33/1096 397/18670 0.02809 0.0947 0.06423 SERPINE2/CPA3/ADAM8/SRGN/TSPAN5/GSN/CFB/BIRC3/IL1B/NOL3/ADAMTS2/ADAMTS3/ASPH/CFP/CST7/CTSH/GAS1/IGKC/CFI/PHB/BAD/NGF/SERPINE1/IGLV6-57/C6/IGLC1/C7/LGMN/C3AR1/WFS1/CYFIP2/NNAT/TNP2 33 BP GO:0043902 positive regulation of multi-organism process 18/1096 188/18670 0.02815 0.09479 0.06429 PLCB1/CCL5/MAPK3/PTAFR/LY96/PC/SASH1/UNC13B/POLR2E/BAD/APOE/HDAC4/POLR2I/TFAP4/VAPA/INHBB/JUN/SUPT5H 18 BP GO:1901292 nucleoside phosphate catabolic process 18/1096 188/18670 0.02815 0.09479 0.06429 ZBTB20/PDE1A/ENPP1/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/GPX1/PDE9A/HDAC4/DDIT4/NUP210/ALDOA/NUDT3 18 BP GO:0009167 purine ribonucleoside monophosphate metabolic process 29/1096 340/18670 0.02818 0.09485 0.06433 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/HPRT1/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1/NUDT3 29 BP GO:0045165 cell fate commitment 24/1096 270/18670 0.02836 0.0954 0.06471 SOX5/CDON/SIX1/GATA3/NTRK3/TCF7L2/BATF/PITX1/MYL2/PDPN/SMAD1/AR/FGFR1/GATA2/PAF1/BMP4/GAS1/ETS2/FZD7/NFE2L1/BMPR1A/SFRP1/HOXA11/GAP43 24 BP GO:0046879 hormone secretion 27/1096 312/18670 0.02843 0.09557 0.06482 SPP1/CCL5/ARL2/EGFR/ADIPOQ/IL1RN/GATA3/TCF7L2/IL1B/RBP4/ADORA1/NMB/CD38/ICA1/HADH/OXCT1/FGFR1/HIF1A/LTBP4/EFNA5/LRP5/BAD/SLC25A4/AGTR1/SFRP1/INHBB/NNAT 27 BP GO:0051928 positive regulation of calcium ion transport 13/1096 123/18670 0.02852 0.09561 0.06485 CCL5/P2RY6/STC1/RGN/LILRA2/PLCG2/F2R/THY1/ATP2A1/CXCL10/CXCL12/CCL2/WFS1 13 BP GO:0030038 contractile actin filament bundle assembly 11/1096 98/18670 0.02853 0.09561 0.06485 ARHGEF10/PTK2B/SMAD3/PAK1/S1PR1/FAM171A1/TNFAIP1/DLC1/ARHGEF5/SFRP1/PFN2 11 BP GO:0043149 stress fiber assembly 11/1096 98/18670 0.02853 0.09561 0.06485 ARHGEF10/PTK2B/SMAD3/PAK1/S1PR1/FAM171A1/TNFAIP1/DLC1/ARHGEF5/SFRP1/PFN2 11 BP GO:0007566 embryo implantation 7/1096 51/18670 0.02855 0.09561 0.06485 SPP1/EMP2/STC1/IL1B/IGFBP7/ARHGDIB/RXRA 7 BP GO:0090102 cochlea development 7/1096 51/18670 0.02855 0.09561 0.06485 SIX1/GATA3/NTRK3/FZD2/GATA2/CCNA2/PVALB 7 BP GO:0120032 regulation of plasma membrane bounded cell projection assembly 17/1096 175/18670 0.02856 0.09561 0.06485 RAC2/DZIP1/FNBP1L/ICAM1/CDK10/AUTS2/CCR7/RALA/SH3YL1/KANK1/NCKAP1/HDAC4/MAP4/COBL/TENM1/PFN2/GAP43 17 BP GO:2000181 negative regulation of blood vessel morphogenesis 17/1096 175/18670 0.02856 0.09561 0.06485 MECP2/TGFB2/SEMA3E/THBS2/SULF1/CX3CR1/PLK2/CCR2/HOXA5/PF4/STAT1/SERPINE1/CXCL10/THBS4/FOXC1/ANGPT2/AMOT 17 BP GO:0005977 glycogen metabolic process 9/1096 74/18670 0.02878 0.09601 0.06512 PPP1R3C/ENPP1/PYGM/PYGB/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2 9 BP GO:0030104 water homeostasis 9/1096 74/18670 0.02878 0.09601 0.06512 UGCG/AKR1B1/ADCY9/NEDD4L/AQP9/ADCY6/AQP1/WFS1/ADCY1 9 BP GO:0031670 cellular response to nutrient 9/1096 74/18670 0.02878 0.09601 0.06512 LPL/POSTN/XBP1/PDK2/COL1A1/GAS6/PIM1/SFRP1/IL15 9 BP GO:0032418 lysosome localization 9/1096 74/18670 0.02878 0.09601 0.06512 IL4R/RAC2/STXBP1/RASGRP1/GAB2/GATA2/STXBP2/S100A13/LAT 9 BP GO:1900076 regulation of cellular response to insulin stimulus 9/1096 74/18670 0.02878 0.09601 0.06512 LPL/ENPP1/PRKCB/IL1B/PAK1/KANK1/CDK4/PTPN2/PTPRE 9 BP GO:1901616 organic hydroxy compound catabolic process 9/1096 74/18670 0.02878 0.09601 0.06512 MAOA/FAH/GK/ALDH3B1/MOXD1/DIO3/AKR1B10/APOE/NUDT3 9 BP GO:0009746 response to hexose 19/1096 202/18670 0.0289 0.09604 0.06514 ZBTB20/LPL/ADIPOQ/PCK1/ICAM1/PTK2B/TCF7L2/NAMPT/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/SLC2A5/BAD/ANGPT2/PCK2 19 BP GO:0042058 regulation of epidermal growth factor receptor signaling pathway 10/1096 86/18670 0.02891 0.09604 0.06514 TGFA/EGFR/HBEGF/ADORA1/BTC/PLAUR/HIP1/DUSP3/PTPN2/SPRY1 10 BP GO:0001782 B cell homeostasis 5/1096 30/18670 0.02894 0.09604 0.06514 TNFAIP3/SH2B2/ADA/HIF1A/NCKAP1L 5 BP GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 5/1096 30/18670 0.02894 0.09604 0.06514 IL4R/CD83/NCKAP1L/CD86/NLRP3 5 BP GO:0045940 positive regulation of steroid metabolic process 5/1096 30/18670 0.02894 0.09604 0.06514 IL1B/ABCG1/APOC1/APOE/AGTR1 5 BP GO:0048873 homeostasis of number of cells within a tissue 5/1096 30/18670 0.02894 0.09604 0.06514 CORO1A/AKT3/GATA2/CCR2/F2R 5 BP GO:0050869 negative regulation of B cell activation 5/1096 30/18670 0.02894 0.09604 0.06514 TNFAIP3/FCGR2B/PARP3/INPP5D/SFRP1 5 BP GO:0070168 negative regulation of biomineral tissue development 5/1096 30/18670 0.02894 0.09604 0.06514 SRGN/ENPP1/PTK2B/GAS6/HIF1A 5 BP GO:0099068 postsynapse assembly 5/1096 30/18670 0.02894 0.09604 0.06514 MAGI2/NTRK3/SHANK2/CDH2/GAP43 5 BP GO:0009267 cellular response to starvation 15/1096 149/18670 0.02897 0.09606 0.06516 FOXO1/PCK1/XBP1/MAPK3/SIK1/DAP/HSPA5/GABARAPL1/GAS6/EHMT2/WDR45/SFRP1/NPRL3/INHBB/JUN 15 BP GO:0009126 purine nucleoside monophosphate metabolic process 29/1096 341/18670 0.02915 0.0966 0.06552 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/HPRT1/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1/NUDT3 29 BP GO:0048863 stem cell differentiation 23/1096 257/18670 0.02931 0.09706 0.06583 SOX5/SEMA5A/TGFB2/SEMA3E/SEMA3A/GATA3/MEOX1/FAM172A/MAPK3/BATF/PTPRC/GATA2/SEMA3C/HIF1A/SEMA4F/BMP4/BMPR1A/JARID2/TWIST1/FOXC1/SFRP1/NRP2/PDGFRA 23 BP GO:0010506 regulation of autophagy 28/1096 327/18670 0.02932 0.09706 0.06583 FOXO1/PIP4K2B/NUPR1/NAMPT/HK2/XBP1/MAPK3/HSPB1/DAP/NPC1/MID2/PLK2/PTPN22/HIF1A/PINK1/UCHL1/LAMP3/EEF1A2/BAD/PIM2/CAPNS1/CTTN/KAT5/BNIP3/NPRL3/IKBKG/ATP6V0D1/SUPT5H 28 BP GO:0048002 antigen processing and presentation of peptide antigen 18/1096 189/18670 0.02948 0.0973 0.066 ITGAV/TAP1/KIF3B/FCGR2B/DCTN3/CTSD/CTSL/CTSF/AP1B1/LAG3/HLA-DOB/HLA-DMA/HLA-DMB/TAPBP/DCTN2/LGMN/NCF2/IKBKG 18 BP GO:0031623 receptor internalization 12/1096 111/18670 0.0296 0.0973 0.066 MAGI2/ANGPT1/VEGFA/SFRP4/CXCL8/PLCG2/DNM1/CAV3/NTF3/USP46/TFRC/ITGB2 12 BP GO:0006069 ethanol oxidation 3/1096 12/18670 0.02978 0.0973 0.066 ADH1B/ADH1A/ADH1C 3 BP GO:0014889 muscle atrophy 3/1096 12/18670 0.02978 0.0973 0.066 GSN/NOL3/IL15 3 BP GO:0033197 response to vitamin E 3/1096 12/18670 0.02978 0.0973 0.066 ADA/CCND1/COL1A1 3 BP GO:0033700 phospholipid efflux 3/1096 12/18670 0.02978 0.0973 0.066 ABCG1/APOC1/APOE 3 BP GO:0034372 very-low-density lipoprotein particle remodeling 3/1096 12/18670 0.02978 0.0973 0.066 LPL/LIPC/APOE 3 BP GO:0044650 adhesion of symbiont to host cell 3/1096 12/18670 0.02978 0.0973 0.066 ICAM1/GAS6/INHBB 3 BP GO:0048302 regulation of isotype switching to IgG isotypes 3/1096 12/18670 0.02978 0.0973 0.066 CD40/IL27RA/PTPRC 3 BP GO:0051657 maintenance of organelle location 3/1096 12/18670 0.02978 0.0973 0.066 GPSM2/AKAP9/ATP2A1 3 BP GO:0051873 killing by host of symbiont cells 3/1096 12/18670 0.02978 0.0973 0.066 CXCL6/PF4/ELANE 3 BP GO:0060442 branching involved in prostate gland morphogenesis 3/1096 12/18670 0.02978 0.0973 0.066 BMP4/SFRP1/RXRA 3 BP GO:0070586 cell-cell adhesion involved in gastrulation 3/1096 12/18670 0.02978 0.0973 0.066 ADIPOQ/IL1RN/MAPK7 3 BP GO:0071472 cellular response to salt stress 3/1096 12/18670 0.02978 0.0973 0.066 AKR1B1/EFHD1/AQP1 3 BP GO:0071481 cellular response to X-ray 3/1096 12/18670 0.02978 0.0973 0.066 GATA3/TP53BP1/SFRP1 3 BP GO:0071639 positive regulation of monocyte chemotactic protein-1 production 3/1096 12/18670 0.02978 0.0973 0.066 ADIPOQ/IL1B/TWIST1 3 BP GO:0071679 commissural neuron axon guidance 3/1096 12/18670 0.02978 0.0973 0.066 VEGFA/NFIB/DAG1 3 BP GO:0072697 protein localization to cell cortex 3/1096 12/18670 0.02978 0.0973 0.066 EPB41L2/GPSM2/PLK1 3 BP GO:0097340 inhibition of cysteine-type endopeptidase activity 3/1096 12/18670 0.02978 0.0973 0.066 BIRC3/NOL3/CST7 3 BP GO:0097341 zymogen inhibition 3/1096 12/18670 0.02978 0.0973 0.066 BIRC3/NOL3/CST7 3 BP GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 3/1096 12/18670 0.02978 0.0973 0.066 SEMA3A/PLXNC1/PLXNA2 3 BP GO:1902337 regulation of apoptotic process involved in morphogenesis 3/1096 12/18670 0.02978 0.0973 0.066 TNFRSF1B/TGFB2/FOXC1 3 BP GO:2000121 regulation of removal of superoxide radicals 3/1096 12/18670 0.02978 0.0973 0.066 GCH1/RGN/FBLN5 3 BP GO:0050796 regulation of insulin secretion 17/1096 176/18670 0.02996 0.09781 0.06634 CCL5/ARL2/TCF7L2/IL1B/RBP4/CD38/ICA1/HADH/OXCT1/HIF1A/EFNA5/LRP5/BAD/SLC25A4/SFRP1/INHBB/NNAT 17 BP GO:0031646 positive regulation of neurological system process 8/1096 63/18670 0.03037 0.09906 0.06719 TNFRSF1B/PTK2B/ITGAX/DAG1/SHANK2/PTAFR/CST7/UNC13B 8 BP GO:0034394 protein localization to cell surface 8/1096 63/18670 0.03037 0.09906 0.06719 CD247/FCN1/ANGPT1/EMP2/NEDD4L/FBLN5/TM9SF4/CAV3 8 BP GO:0070301 cellular response to hydrogen peroxide 11/1096 99/18670 0.03047 0.0993 0.06735 FOXO1/TNFAIP3/AXL/PCGF2/TRAP1/PINK1/NQO1/MAPK7/AQP1/MAPK13/BNIP3 11 BP GO:0031644 regulation of neurological system process 14/1096 137/18670 0.0305 0.09935 0.06738 TNFRSF1B/PTK2B/ITGAX/DAG1/SHANK2/ADORA1/CTSC/PTAFR/CST7/AKAP9/F2R/UNC13B/TYMP/NPTX2 14 BP GO:0017157 regulation of exocytosis 20/1096 217/18670 0.03076 0.1001 0.06789 IL4R/RAC2/STXBP1/PRKCB/FCGR2B/SDC1/GAB2/RAB27A/PTAFR/RALA/GATA2/STXBP2/SYT17/CCR2/UNC13B/RIMS3/ABR/ITGB2/PFN2/ADCY1 20 BP GO:0060348 bone development 20/1096 217/18670 0.03076 0.1001 0.06789 XYLT1/STC1/SULF1/PTPN6/SFRP4/RGN/ALPL/PTPRC/SMAD1/COL1A1/BMP4/PAPSS2/LRP5/DHRS3/TWIST1/FOXC1/CARM1/FGFR3/OSR2/HOXA11 20 BP GO:0071248 cellular response to metal ion 18/1096 190/18670 0.03085 0.1003 0.06803 FABP4/GSN/EGFR/ANK3/CPNE1/DAXX/MAPK3/HSPA5/MT1G/SYT17/NQO1/NFE2L1/CCNB1/AQP1/LGMN/BNIP3/JUN/ADCY1 18 BP GO:0051052 regulation of DNA metabolic process 35/1096 429/18670 0.03086 0.1003 0.06803 MECP2/IL7R/EGFR/ADIPOQ/GATA3/PTK2B/PARM1/ZNF365/CD40/ATRX/TP53BP1/MAPK3/IL27RA/ID3/MAP3K4/RGN/GZMA/PTPRC/FGFR1/TNFAIP1/ERCC1/CCNA2/PARP3/EHMT2/USP7/TWIST1/ZNF91/FAM168A/TFRC/CUL4A/TFIP11/TSPYL2/CDC6/JUN/MBD2 35 BP GO:0006112 energy reserve metabolic process 10/1096 87/18670 0.03101 0.1006 0.06825 PPP1R3C/ENPP1/PYGM/PYGB/GFPT1/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2 10 BP GO:0051781 positive regulation of cell division 10/1096 87/18670 0.03101 0.1006 0.06825 TGFA/TGFB2/VEGFA/SVIL/KIF3B/IL1B/CDC25B/BTC/THBS4/CDC6 10 BP GO:0006073 cellular glucan metabolic process 9/1096 75/18670 0.03107 0.1006 0.06825 PPP1R3C/ENPP1/PYGM/PYGB/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2 9 BP GO:0010611 regulation of cardiac muscle hypertrophy 9/1096 75/18670 0.03107 0.1006 0.06825 FOXO1/TNFRSF1B/SMAD3/PAK1/RGS2/CAV3/PIN1/PDE9A/JARID2 9 BP GO:0044042 glucan metabolic process 9/1096 75/18670 0.03107 0.1006 0.06825 PPP1R3C/ENPP1/PYGM/PYGB/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2 9 BP GO:1902117 positive regulation of organelle assembly 9/1096 75/18670 0.03107 0.1006 0.06825 DZIP1/LCP1/PIP4K2B/GPSM2/SDC1/CNOT1/G3BP1/SPAG5/ARHGEF5 9 BP GO:0010955 negative regulation of protein processing 6/1096 41/18670 0.03124 0.1008 0.0684 SERPINE2/BIRC3/NOL3/CST7/GAS1/SERPINE1 6 BP GO:0019432 triglyceride biosynthetic process 6/1096 41/18670 0.03124 0.1008 0.0684 LPL/PCK1/SIK1/GK/RGN/PCK2 6 BP GO:0040019 positive regulation of embryonic development 6/1096 41/18670 0.03124 0.1008 0.0684 PLCB1/SIX1/GATA3/DAG1/AR/AMOT 6 BP GO:0090279 regulation of calcium ion import 6/1096 41/18670 0.03124 0.1008 0.0684 STC1/PLN/CAV3/ATP2A1/CXCL12/CCL2 6 BP GO:1903053 regulation of extracellular matrix organization 6/1096 41/18670 0.03124 0.1008 0.0684 TNFRSF1B/DDR2/DAG1/SMAD3/PDPN/TCF15 6 BP GO:1903318 negative regulation of protein maturation 6/1096 41/18670 0.03124 0.1008 0.0684 SERPINE2/BIRC3/NOL3/CST7/GAS1/SERPINE1 6 BP GO:0003179 heart valve morphogenesis 7/1096 52/18670 0.03138 0.1011 0.06854 TGFB2/GATA3/OLFM1/BMP4/BMPR1A/TWIST1/SMAD6 7 BP GO:0031529 ruffle organization 7/1096 52/18670 0.03138 0.1011 0.06854 ICAM1/PLEK/CCR7/SH3YL1/KANK1/COBL/PFN2 7 BP GO:0046580 negative regulation of Ras protein signal transduction 7/1096 52/18670 0.03138 0.1011 0.06854 TGFB2/TIMP2/TNFAIP1/KANK1/RAPGEF1/DLC1/SPRY1 7 BP GO:0060421 positive regulation of heart growth 7/1096 52/18670 0.03138 0.1011 0.06854 TGFBR3/FGFR1/PIN1/PIM1/CCNB1/BASP1/BMPR1A 7 BP GO:0060491 regulation of cell projection assembly 17/1096 177/18670 0.0314 0.1011 0.06856 RAC2/DZIP1/FNBP1L/ICAM1/CDK10/AUTS2/CCR7/RALA/SH3YL1/KANK1/NCKAP1/HDAC4/MAP4/COBL/TENM1/PFN2/GAP43 17 BP GO:0031109 microtubule polymerization or depolymerization 12/1096 112/18670 0.03145 0.1011 0.06858 MECP2/ARL2/CRYAB/MAPRE2/PAK1/MAPRE3/CDH5/CAV3/AKAP9/CAMSAP2/STMN2/TUBGCP4 12 BP GO:1903828 negative regulation of cellular protein localization 12/1096 112/18670 0.03145 0.1011 0.06858 ANGPT1/ADIPOQ/DCLK1/NEDD4L/LILRB4/MFHAS1/PKIG/CAV3/UBE2J1/GBP1/CSK/LYPLA1 12 BP GO:0051961 negative regulation of nervous system development 27/1096 315/18670 0.03156 0.1012 0.06866 SPP1/SEMA5A/SEMA3E/SEMA3A/NTRK3/ZNF365/IL1B/ID3/CTSC/CD38/RAB29/ID1/ADCY6/PLK2/INPP5F/KANK1/SEMA3C/THY1/SEMA4F/ID4/DIO3/TLR2/APOE/STMN2/BMPR1A/CARM1/COL3A1 27 BP GO:0003177 pulmonary valve development 4/1096 21/18670 0.03175 0.1012 0.06866 TNFRSF1B/TGFB2/BMP4/SMAD6 4 BP GO:0006067 ethanol metabolic process 4/1096 21/18670 0.03175 0.1012 0.06866 ADH1B/ADH1A/ADH1C/ALDH3B1 4 BP GO:0010310 regulation of hydrogen peroxide metabolic process 4/1096 21/18670 0.03175 0.1012 0.06866 RAC2/PINK1/ZNF205/PRDX2 4 BP GO:0030502 negative regulation of bone mineralization 4/1096 21/18670 0.03175 0.1012 0.06866 SRGN/ENPP1/PTK2B/HIF1A 4 BP GO:0030728 ovulation 4/1096 21/18670 0.03175 0.1012 0.06866 IL4R/TNFAIP6/RGS2/INHBB 4 BP GO:0035162 embryonic hemopoiesis 4/1096 21/18670 0.03175 0.1012 0.06866 VEGFA/GATA3/GATA2/HIF1A 4 BP GO:0046716 muscle cell cellular homeostasis 4/1096 21/18670 0.03175 0.1012 0.06866 PFKM/CAV3/HIF1A/ALDOA 4 BP GO:0046827 positive regulation of protein export from nucleus 4/1096 21/18670 0.03175 0.1012 0.06866 TCF7L2/IL1B/GAS6/PPM1A 4 BP GO:0048245 eosinophil chemotaxis 4/1096 21/18670 0.03175 0.1012 0.06866 CCL5/CCL13/CCL2/CCL7 4 BP GO:0055093 response to hyperoxia 4/1096 21/18670 0.03175 0.1012 0.06866 FOXO1/COL1A1/CDK4/BNIP3 4 BP GO:0071498 cellular response to fluid shear stress 4/1096 21/18670 0.03175 0.1012 0.06866 PTK2B/ASS1/MAPK7/TFPI2 4 BP GO:0090280 positive regulation of calcium ion import 4/1096 21/18670 0.03175 0.1012 0.06866 STC1/ATP2A1/CXCL12/CCL2 4 BP GO:1901739 regulation of myoblast fusion 4/1096 21/18670 0.03175 0.1012 0.06866 IL4R/CD53/CXCL10/TNFSF14 4 BP GO:1903055 positive regulation of extracellular matrix organization 4/1096 21/18670 0.03175 0.1012 0.06866 DDR2/DAG1/SMAD3/PDPN 4 BP GO:0009135 purine nucleoside diphosphate metabolic process 14/1096 138/18670 0.03218 0.1025 0.06951 ZBTB20/NUPR1/PFKM/HK2/AMPD3/INSR/HIF1A/BAD/AK1/HDAC4/DDIT4/GUK1/NUP210/ALDOA 14 BP GO:0009179 purine ribonucleoside diphosphate metabolic process 14/1096 138/18670 0.03218 0.1025 0.06951 ZBTB20/NUPR1/PFKM/HK2/AMPD3/INSR/HIF1A/BAD/AK1/HDAC4/DDIT4/GUK1/NUP210/ALDOA 14 BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 11/1096 100/18670 0.03249 0.1034 0.07014 CD226/ADA/GATA3/CD40/IL1B/TP53BP1/IL27RA/PTPRC/CCR2/NLRP3/TFRC 11 BP GO:0002724 regulation of T cell cytokine production 5/1096 31/18670 0.03289 0.1042 0.07066 TNFRSF1B/GATA3/IL1B/CCR2/NLRP3 5 BP GO:0003401 axis elongation 5/1096 31/18670 0.03289 0.1042 0.07066 MAGI2/SIX1/BMP4/SFRP1/SPRY1 5 BP GO:0009154 purine ribonucleotide catabolic process 5/1096 31/18670 0.03289 0.1042 0.07066 PDE1A/AMPD3/HPRT1/PDE9A/NUDT3 5 BP GO:0010165 response to X-ray 5/1096 31/18670 0.03289 0.1042 0.07066 GATA3/TP53BP1/CCND1/ERCC1/SFRP1 5 BP GO:0033687 osteoblast proliferation 5/1096 31/18670 0.03289 0.1042 0.07066 ITGAV/SMAD3/NELL1/SFRP1/OSR2 5 BP GO:0043457 regulation of cellular respiration 5/1096 31/18670 0.03289 0.1042 0.07066 TRAP1/HIF1A/PINK1/CCNB1/BNIP3 5 BP GO:0050849 negative regulation of calcium-mediated signaling 5/1096 31/18670 0.03289 0.1042 0.07066 PLEK/CASQ2/DYRK2/HOMER3/MAPK7 5 BP GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 5/1096 31/18670 0.03289 0.1042 0.07066 S1PR1/TGM2/F2R/AGTR1/C3AR1 5 BP GO:0090075 relaxation of muscle 5/1096 31/18670 0.03289 0.1042 0.07066 ADORA1/PLN/RGS2/ATP2A1/PRKG1 5 BP GO:0045669 positive regulation of osteoblast differentiation 8/1096 64/18670 0.033 0.1043 0.07072 DDR2/ZHX3/NELL1/SMAD1/BMP4/LRP5/CTNNBIP1/BMPR1A 8 BP GO:0046579 positive regulation of Ras protein signal transduction 8/1096 64/18670 0.033 0.1043 0.07072 MAPRE2/RASGRP1/AUTS2/RAPGEF1/F2R/NGF/VAV1/COL3A1 8 BP GO:0046782 regulation of viral transcription 8/1096 64/18670 0.033 0.1043 0.07072 CCL5/MID2/POLR2E/HDAC1/POLR2I/TFAP4/JUN/SUPT5H 8 BP GO:2000378 negative regulation of reactive oxygen species metabolic process 8/1096 64/18670 0.033 0.1043 0.07072 CRYAB/HK2/RGN/TRAP1/HIF1A/PINK1/BNIP3/SLC18A2 8 BP GO:0032088 negative regulation of NF-kappaB transcription factor activity 10/1096 88/18670 0.03322 0.1048 0.07109 TNFAIP3/CD200/AIM2/ADORA3/DAP/NFKBIA/USP7/NLRP3/TRAF3/PRDX2 10 BP GO:1900407 regulation of cellular response to oxidative stress 10/1096 88/18670 0.03322 0.1048 0.07109 HSPB1/GCH1/RGN/FBLN5/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 10 BP GO:1901888 regulation of cell junction assembly 10/1096 88/18670 0.03322 0.1048 0.07109 VEGFA/EPHA3/SMAD3/RAPGEF1/THY1/DLC1/EFNA5/PRKCH/SFRP1/DUSP3 10 BP GO:0043244 regulation of protein complex disassembly 12/1096 113/18670 0.03338 0.1053 0.07139 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/ASPH/INSR/CAPG/CAMSAP2/SCAF8/STMN2/BNIP3 12 BP GO:0050680 negative regulation of epithelial cell proliferation 16/1096 165/18670 0.03341 0.1053 0.07141 RUNX3/TGFBR3/TGFB2/NFIB/GATA3/NUPR1/SULF1/RGN/MAGED1/AR/BMP4/STAT1/APOE/SFRP1/CCL2/FLT1 16 BP GO:0042278 purine nucleoside metabolic process 9/1096 76/18670 0.03348 0.1054 0.07148 ADA/AMPD3/HPRT1/AHCY/NME3/GUK1/IMPDH1/IMPDH2/AHCYL2 9 BP GO:0061045 negative regulation of wound healing 9/1096 76/18670 0.03348 0.1054 0.07148 SERPINE2/SMAD3/TFPI/PLAUR/PRKG1/APOE/SERPINE1/APCS/PDGFRA 9 BP GO:0008202 steroid metabolic process 28/1096 331/18670 0.03354 0.1055 0.07156 SPP1/MECP2/CH25H/IL1B/AKR1B1/CYB5R1/IGFBP7/CYB5R3/HDLBP/NFKB1/LIPC/NPC1/ABCG1/SLC27A2/FGFR1/APOC1/ACOX2/NFE2L1/LBR/PMVK/HSD11B2/APOE/APOF/AGTR1/LGMN/PDGFRA/STS/RXRA 28 BP GO:0001890 placenta development 15/1096 152/18670 0.03377 0.1062 0.07203 SPP1/ADAM19/EGFR/ADA/STC1/MAPK3/MAP3K4/LDOC1/GATA2/HIF1A/HTRA1/PHLDA2/SPINT2/ST14/RXRA 15 BP GO:0046031 ADP metabolic process 13/1096 126/18670 0.03383 0.1063 0.07211 ZBTB20/NUPR1/PFKM/HK2/AMPD3/INSR/HIF1A/BAD/AK1/HDAC4/DDIT4/NUP210/ALDOA 13 BP GO:0043270 positive regulation of ion transport 24/1096 275/18670 0.03416 0.1073 0.07277 CCL5/P2RY6/STXBP1/ANK3/STC1/IL1B/FXYD1/ADORA1/RGN/PTAFR/LILRA2/PLCG2/CCR2/AKAP9/F2R/THY1/PINK1/ATP2A1/APOE/CXCL10/CXCL12/CCL2/FHL1/WFS1 24 BP GO:0030195 negative regulation of blood coagulation 7/1096 53/18670 0.03439 0.1077 0.07305 SERPINE2/TFPI/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA 7 BP GO:0031638 zymogen activation 7/1096 53/18670 0.03439 0.1077 0.07305 SERPINE2/ASPH/CTSH/BAD/SERPINE1/LGMN/CYFIP2 7 BP GO:0045661 regulation of myoblast differentiation 7/1096 53/18670 0.03439 0.1077 0.07305 PLCB1/CDON/ID3/TRIP4/BMP4/CXCL10/TNFSF14 7 BP GO:0050704 regulation of interleukin-1 secretion 7/1096 53/18670 0.03439 0.1077 0.07305 TNFAIP3/LPL/AIM2/CCR7/LILRA2/GAS6/NLRP3 7 BP GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 7/1096 53/18670 0.03439 0.1077 0.07305 PTPN6/PTPRC/INPP5F/THY1/NTF3/SFRP1/PTPN2 7 BP GO:0023061 signal release 37/1096 462/18670 0.03443 0.1077 0.07305 SPP1/CCL5/ARL2/STXBP1/STX11/EGFR/ADIPOQ/IL1RN/GATA3/PRKCB/TCF7L2/IL1B/RBP4/ADORA1/NMB/CD38/ICA1/HADH/OXCT1/FGFR1/SYT17/HIF1A/LTBP4/EFNA5/UNC13B/LRP5/BAD/SNCG/RIMS3/SLC25A4/AGTR1/SFRP1/PFN2/INHBB/NNAT/SLC18A2/ADCY1 37 BP GO:0048736 appendage development 17/1096 179/18670 0.03445 0.1077 0.07305 ZBTB16/HOXA10/TGFB2/ATRX/PAM/PITX1/ASPH/FGFR1/SEMA3C/BMP4/B9D1/HDAC1/BMPR1A/PLXNA2/TWIST1/OSR2/HOXA11 17 BP GO:0060173 limb development 17/1096 179/18670 0.03445 0.1077 0.07305 ZBTB16/HOXA10/TGFB2/ATRX/PAM/PITX1/ASPH/FGFR1/SEMA3C/BMP4/B9D1/HDAC1/BMPR1A/PLXNA2/TWIST1/OSR2/HOXA11 17 BP GO:0032611 interleukin-1 beta production 11/1096 101/18670 0.03461 0.1081 0.07331 TNFAIP3/LPL/AIM2/IL1B/SMAD3/CCR7/HSPB1/LILRA2/CX3CR1/F2R/NLRP3 11 BP GO:0097006 regulation of plasma lipoprotein particle levels 11/1096 101/18670 0.03461 0.1081 0.07331 LPL/ADIPOQ/HDLBP/LIPC/NPC1/ABCG1/APOC1/PLA2G7/APOE/CSK/AGTR1 11 BP GO:0009123 nucleoside monophosphate metabolic process 31/1096 375/18670 0.03464 0.1081 0.07335 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/HPRT1/MYH7/HIF1A/PINK1/DCK/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/TK2/ALDOA/UQCRC1/NUDT3 31 BP GO:0017145 stem cell division 6/1096 42/18670 0.0347 0.1082 0.07336 ZBTB16/SOX5/WWTR1/TGFB2/FGFR1/FZD7 6 BP GO:0031641 regulation of myelination 6/1096 42/18670 0.0347 0.1082 0.07336 TNFRSF1B/ITGAX/DAG1/CTSC/CST7/TYMP 6 BP GO:0032958 inositol phosphate biosynthetic process 6/1096 42/18670 0.0347 0.1082 0.07336 PLCB1/P2RY6/PTK2B/PLEK/PTAFR/PLCG2 6 BP GO:0034330 cell junction organization 25/1096 290/18670 0.03532 0.11 0.07463 ARL2/TGFB2/VEGFA/EPHA3/MAPRE2/PTK2B/ACTN1/SMAD3/DST/TLN2/CDH5/DLG5/RAPGEF1/F2R/THY1/DLC1/ITGA5/EFNA5/PECAM1/PRKCH/CTTN/CSK/CDH2/SFRP1/DUSP3 25 BP GO:0046427 positive regulation of JAK-STAT cascade 10/1096 89/18670 0.03554 0.1106 0.07501 CCL5/PTK2B/CD40/AKR1B1/HCLS1/F2R/PECAM1/FGFR3/CRLF1/IL15 10 BP GO:0060021 roof of mouth development 10/1096 89/18670 0.03554 0.1106 0.07501 TGFBR3/TGFB2/FZD2/ASPH/DHRS3/BMPR1A/TWIST1/OSR2/PDGFRA/NPRL3 10 BP GO:0009185 ribonucleoside diphosphate metabolic process 14/1096 140/18670 0.03575 0.1111 0.07536 ZBTB20/NUPR1/PFKM/HK2/AMPD3/INSR/HIF1A/BAD/AK1/HDAC4/DDIT4/GUK1/NUP210/ALDOA 14 BP GO:1903364 positive regulation of cellular protein catabolic process 14/1096 140/18670 0.03575 0.1111 0.07536 TNFAIP3/PTK2B/NUPR1/RGN/RNF144A/CTSC/TRIB2/PLK2/CAV3/APOE/PLK1/USP5/HERPUD1/PTTG1IP 14 BP GO:0051148 negative regulation of muscle cell differentiation 8/1096 65/18670 0.03577 0.1111 0.07536 MECP2/PAK1/XBP1/RGS2/CAV3/FZD7/CXCL10/HDAC4 8 BP GO:0034284 response to monosaccharide 19/1096 207/18670 0.03585 0.1113 0.07549 ZBTB20/LPL/ADIPOQ/PCK1/ICAM1/PTK2B/TCF7L2/NAMPT/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/SLC2A5/BAD/ANGPT2/PCK2 19 BP GO:0008344 adult locomotory behavior 9/1096 77/18670 0.03602 0.1117 0.07574 MECP2/TMOD1/ZIC1/NPC1/INPP5F/UCHL1/SNCG/GLRB/CXCL12 9 BP GO:0016575 histone deacetylation 9/1096 77/18670 0.03602 0.1117 0.07574 VEGFA/NACC2/PINK1/HDAC1/ZNHIT1/PHB/TADA3/MSL3/HDAC4 9 BP GO:1905330 regulation of morphogenesis of an epithelium 17/1096 180/18670 0.03605 0.1117 0.07574 MAGI2/VEGFA/SIX1/GATA3/ITGAX/SULF1/FZD2/MAGED1/AR/FGFR1/CAV3/BMP4/FZD7/STAT1/CXCL10/SFRP1/RXRA 17 BP GO:0002052 positive regulation of neuroblast proliferation 4/1096 22/18670 0.03706 0.1117 0.07574 VEGFA/CX3CR1/SMARCD3/HIF1A 4 BP GO:0006925 inflammatory cell apoptotic process 4/1096 22/18670 0.03706 0.1117 0.07574 CCL5/CCR5/CTSL/IRF7 4 BP GO:0032469 endoplasmic reticulum calcium ion homeostasis 4/1096 22/18670 0.03706 0.1117 0.07574 TGM2/ATP2A1/WFS1/HERPUD1 4 BP GO:0042359 vitamin D metabolic process 4/1096 22/18670 0.03706 0.1117 0.07574 IL1B/NFKB1/FGFR1/LGMN 4 BP GO:0043496 regulation of protein homodimerization activity 4/1096 22/18670 0.03706 0.1117 0.07574 HSPA5/ITGA4/ID1/PCBD1 4 BP GO:0044321 response to leptin 4/1096 22/18670 0.03706 0.1117 0.07574 UGCG/CCND1/CCNA2/INHBB 4 BP GO:0044342 type B pancreatic cell proliferation 4/1096 22/18670 0.03706 0.1117 0.07574 NUPR1/IGFBP5/BAD/SFRP1 4 BP GO:0046058 cAMP metabolic process 4/1096 22/18670 0.03706 0.1117 0.07574 ADCY9/PTHLH/ADCY6/ADCY1 4 BP GO:0048305 immunoglobulin secretion 4/1096 22/18670 0.03706 0.1117 0.07574 CD40/RBP4/XBP1/TNFRSF4 4 BP GO:0050765 negative regulation of phagocytosis 4/1096 22/18670 0.03706 0.1117 0.07574 ADIPOQ/FCGR2B/TLR2/CSK 4 BP GO:0051000 positive regulation of nitric-oxide synthase activity 4/1096 22/18670 0.03706 0.1117 0.07574 PTK2B/GCH1/HIF1A/APOE 4 BP GO:0060390 regulation of SMAD protein signal transduction 4/1096 22/18670 0.03706 0.1117 0.07574 WWTR1/SPTBN1/BMP4/BMPR1A 4 BP GO:0071379 cellular response to prostaglandin stimulus 4/1096 22/18670 0.03706 0.1117 0.07574 P2RY6/ADCY6/PTGER2/SFRP1 4 BP GO:0072643 interferon-gamma secretion 4/1096 22/18670 0.03706 0.1117 0.07574 RASGRP1/GATA3/CD2/PTPN22 4 BP GO:0090189 regulation of branching involved in ureteric bud morphogenesis 4/1096 22/18670 0.03706 0.1117 0.07574 VEGFA/SIX1/MAGED1/BMP4 4 BP GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 4/1096 22/18670 0.03706 0.1117 0.07574 VEGFA/XBP1/SMAD1/HIF1A 4 BP GO:2000773 negative regulation of cellular senescence 4/1096 22/18670 0.03706 0.1117 0.07574 AKT3/NAMPT/PLK2/TWIST1 4 BP GO:0001765 membrane raft assembly 3/1096 13/18670 0.03707 0.1117 0.07574 EMP2/RFTN1/CAV3 3 BP GO:0001886 endothelial cell morphogenesis 3/1096 13/18670 0.03707 0.1117 0.07574 STC1/ID1/PECAM1 3 BP GO:0001973 adenosine receptor signaling pathway 3/1096 13/18670 0.03707 0.1117 0.07574 ADA/ADORA3/ADORA1 3 BP GO:0009162 deoxyribonucleoside monophosphate metabolic process 3/1096 13/18670 0.03707 0.1117 0.07574 DCK/GUK1/TK2 3 BP GO:0009650 UV protection 3/1096 13/18670 0.03707 0.1117 0.07574 MFAP4/ERCC1/GPX1 3 BP GO:0010870 positive regulation of receptor biosynthetic process 3/1096 13/18670 0.03707 0.1117 0.07574 HOXA5/HIF1A/HDAC1 3 BP GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 3/1096 13/18670 0.03707 0.1117 0.07574 TNFAIP3/LILRA2/PRDX2 3 BP GO:0032754 positive regulation of interleukin-5 production 3/1096 13/18670 0.03707 0.1117 0.07574 GATA3/IL17RA/NLRP3 3 BP GO:0038065 collagen-activated signaling pathway 3/1096 13/18670 0.03707 0.1117 0.07574 DDR2/COL1A1/COL4A1 3 BP GO:0042415 norepinephrine metabolic process 3/1096 13/18670 0.03707 0.1117 0.07574 GATA3/AKR1B1/MOXD1 3 BP GO:0043301 negative regulation of leukocyte degranulation 3/1096 13/18670 0.03707 0.1117 0.07574 FCGR2B/CCR2/ABR 3 BP GO:0045820 negative regulation of glycolytic process 3/1096 13/18670 0.03707 0.1117 0.07574 NUPR1/HDAC4/DDIT4 3 BP GO:0048291 isotype switching to IgG isotypes 3/1096 13/18670 0.03707 0.1117 0.07574 CD40/IL27RA/PTPRC 3 BP GO:0060347 heart trabecula formation 3/1096 13/18670 0.03707 0.1117 0.07574 TGFBR3/RBP4/CAV3 3 BP GO:0060601 lateral sprouting from an epithelium 3/1096 13/18670 0.03707 0.1117 0.07574 SULF1/AR/BMP4 3 BP GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development 3/1096 13/18670 0.03707 0.1117 0.07574 PAK1/RGS2/CAV3 3 BP GO:0061478 response to platelet aggregation inhibitor 3/1096 13/18670 0.03707 0.1117 0.07574 ADCY6/EFNA5/ADCY1 3 BP GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 3/1096 13/18670 0.03707 0.1117 0.07574 TNFAIP3/NFKBIA/PTPN22 3 BP GO:0070831 basement membrane assembly 3/1096 13/18670 0.03707 0.1117 0.07574 PXDN/DAG1/LAMB2 3 BP GO:0072044 collecting duct development 3/1096 13/18670 0.03707 0.1117 0.07574 AKR1B1/DLG5/BMP4 3 BP GO:0072182 regulation of nephron tubule epithelial cell differentiation 3/1096 13/18670 0.03707 0.1117 0.07574 WWTR1/GATA3/STAT1 3 BP GO:0090594 inflammatory response to wounding 3/1096 13/18670 0.03707 0.1117 0.07574 CCR2/HIF1A/F2R 3 BP GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 3/1096 13/18670 0.03707 0.1117 0.07574 XBP1/ATF6/PTPN2 3 BP GO:1900272 negative regulation of long-term synaptic potentiation 3/1096 13/18670 0.03707 0.1117 0.07574 ADORA1/CX3CR1/APOE 3 BP GO:1901550 regulation of endothelial cell development 3/1096 13/18670 0.03707 0.1117 0.07574 VEGFA/IL1B/CDH5 3 BP GO:1902430 negative regulation of amyloid-beta formation 3/1096 13/18670 0.03707 0.1117 0.07574 BIN1/PIN1/APOE 3 BP GO:1902713 regulation of interferon-gamma secretion 3/1096 13/18670 0.03707 0.1117 0.07574 RASGRP1/CD2/PTPN22 3 BP GO:1903140 regulation of establishment of endothelial barrier 3/1096 13/18670 0.03707 0.1117 0.07574 VEGFA/IL1B/CDH5 3 BP GO:0003176 aortic valve development 5/1096 32/18670 0.03717 0.1117 0.07574 TNFRSF1B/GATA3/BMP4/TWIST1/SMAD6 5 BP GO:0009261 ribonucleotide catabolic process 5/1096 32/18670 0.03717 0.1117 0.07574 PDE1A/AMPD3/HPRT1/PDE9A/NUDT3 5 BP GO:0032814 regulation of natural killer cell activation 5/1096 32/18670 0.03717 0.1117 0.07574 AXL/RASGRP1/GAS6/PTPN22/IL15 5 BP GO:0035587 purinergic receptor signaling pathway 5/1096 32/18670 0.03717 0.1117 0.07574 P2RY6/ADA/ADORA3/ADORA1/PTAFR 5 BP GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 5/1096 32/18670 0.03717 0.1117 0.07574 PTK2B/CCR7/FGFR3/PDGFRA/FLT1 5 BP GO:0045589 regulation of regulatory T cell differentiation 5/1096 32/18670 0.03717 0.1117 0.07574 LILRB2/IRF1/LILRB4/LAG3/IL2RA 5 BP GO:0045987 positive regulation of smooth muscle contraction 5/1096 32/18670 0.03717 0.1117 0.07574 ADA/PTAFR/F2R/CTTN/CHRM3 5 BP GO:0055022 negative regulation of cardiac muscle tissue growth 5/1096 32/18670 0.03717 0.1117 0.07574 PAK1/RBP4/RGS2/CAV3/JARID2 5 BP GO:0055094 response to lipoprotein particle 5/1096 32/18670 0.03717 0.1117 0.07574 LPL/NPC1/MYD88/APOE/ITGB2 5 BP GO:0060317 cardiac epithelial to mesenchymal transition 5/1096 32/18670 0.03717 0.1117 0.07574 TGFBR3/TGFB2/OLFM1/TWIST1/SPRY1 5 BP GO:0061117 negative regulation of heart growth 5/1096 32/18670 0.03717 0.1117 0.07574 PAK1/RBP4/RGS2/CAV3/JARID2 5 BP GO:0070570 regulation of neuron projection regeneration 5/1096 32/18670 0.03717 0.1117 0.07574 SPP1/NTRK3/INPP5F/THY1/PTPRF 5 BP GO:1900745 positive regulation of p38MAPK cascade 5/1096 32/18670 0.03717 0.1117 0.07574 VEGFA/IL1B/MAP3K4/MFHAS1/SASH1 5 BP GO:0006090 pyruvate metabolic process 15/1096 154/18670 0.03729 0.112 0.07595 ZBTB20/PCK1/NUPR1/PFKM/HK2/PDK2/INSR/PC/HIF1A/HDAC4/DDIT4/SDS/NUP210/ALDOA/PCK2 15 BP GO:0030111 regulation of Wnt signaling pathway 30/1096 363/18670 0.03731 0.112 0.07597 FOXO1/TNFAIP3/WIF1/SEMA5A/WWTR1/CDK14/EGFR/TCF7L2/SMAD3/SULF1/SFRP4/NFKB1/COL1A1/KANK1/IGFBP6/PIN1/RAPGEF1/IGFBP2/FZD7/HDAC1/GPC5/TLR2/APOE/CTNNBIP1/G3BP1/CDH2/SFRP1/PPM1A/CBY1/MBD2 30 BP GO:0009124 nucleoside monophosphate biosynthetic process 19/1096 208/18670 0.03737 0.1121 0.07605 ZBTB20/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/PINK1/DCK/AK1/HDAC4/DDIT4/IMPDH1/NUP210/IMPDH2/TK2/ALDOA 19 BP GO:1904375 regulation of protein localization to cell periphery 12/1096 115/18670 0.0375 0.1125 0.07627 EPHA3/EGFR/EPB41L2/DAG1/GPSM2/SPTBN1/AR/GBP1/PRKCH/CSK/PLK1/LYPLA1 12 BP GO:0050994 regulation of lipid catabolic process 7/1096 54/18670 0.03759 0.1125 0.07632 RARRES2/THRA/IL1B/ADORA1/APOC1/CDK4/TWIST1 7 BP GO:0051353 positive regulation of oxidoreductase activity 7/1096 54/18670 0.03759 0.1125 0.07632 PTK2B/IL1B/GCH1/RGN/HIF1A/APOE/AGTR1 7 BP GO:1900047 negative regulation of hemostasis 7/1096 54/18670 0.03759 0.1125 0.07632 SERPINE2/TFPI/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA 7 BP GO:0008286 insulin receptor signaling pathway 14/1096 141/18670 0.03764 0.1126 0.07639 FOXO1/RARRES2/SH2B2/ENPP1/PRKCB/IL1B/PAK1/PDK2/INSR/KANK1/CDK4/PTPN2/ATP6V0D1/PTPRE 14 BP GO:0051147 regulation of muscle cell differentiation 17/1096 181/18670 0.0377 0.1127 0.07647 IL4R/MECP2/CDON/PAK1/XBP1/SIK1/RGS2/CD53/CAV3/PIN1/SMARCD3/BMP4/FZD7/CXCL10/HDAC4/TNFSF14/CDH2 17 BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 29/1096 349/18670 0.03777 0.1129 0.07658 TGFBR3/MAGI2/WWTR1/TGFB2/SMAD3/SULF1/MAPK3/SFRP4/SPTBN1/HSPA5/CDH5/SMAD1/ID1/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/BMP4/HTRA1/GDF10/BMPR1A/SFRP1/PPM1A/COL3A1/SMAD6/INHBB/ADAMTSL2/JUN 29 BP GO:0031058 positive regulation of histone modification 10/1096 90/18670 0.03797 0.1134 0.07689 MECP2/VEGFA/GATA3/IL1B/AUTS2/MAPK3/PAF1/PINK1/CCNB1/JARID2 10 BP GO:0032651 regulation of interleukin-1 beta production 10/1096 90/18670 0.03797 0.1134 0.07689 TNFAIP3/LPL/AIM2/SMAD3/CCR7/HSPB1/LILRA2/CX3CR1/F2R/NLRP3 10 BP GO:0060070 canonical Wnt signaling pathway 28/1096 335/18670 0.0382 0.114 0.07732 FOXO1/SEMA5A/WWTR1/CDK14/EGFR/GATA3/TCF7/TCF7L2/SMAD3/SDC1/SFRP4/FZD2/NFKB1/COL1A1/KANK1/IGFBP6/PIN1/RAPGEF1/IGFBP2/FZD7/HDAC1/LRP5/GPC5/APOE/G3BP1/CDH2/SFRP1/PPM1A 28 BP GO:0046460 neutral lipid biosynthetic process 6/1096 43/18670 0.0384 0.1143 0.07753 LPL/PCK1/SIK1/GK/RGN/PCK2 6 BP GO:0046463 acylglycerol biosynthetic process 6/1096 43/18670 0.0384 0.1143 0.07753 LPL/PCK1/SIK1/GK/RGN/PCK2 6 BP GO:0051602 response to electrical stimulus 6/1096 43/18670 0.0384 0.1143 0.07753 BTG2/CD14/S100A13/AKAP9/NQO1/EEF1A2 6 BP GO:0055026 negative regulation of cardiac muscle tissue development 6/1096 43/18670 0.0384 0.1143 0.07753 PAK1/RBP4/RGS2/CAV3/FZD7/JARID2 6 BP GO:0071364 cellular response to epidermal growth factor stimulus 6/1096 43/18670 0.0384 0.1143 0.07753 EGFR/ID1/COL1A1/SKAP1/FOXC1/DUSP3 6 BP GO:0021954 central nervous system neuron development 9/1096 78/18670 0.03868 0.115 0.07799 GABRB1/SEMA3A/NFIB/DCLK1/BTG2/HPRT1/GATA2/NRP2/ATF5 9 BP GO:0042246 tissue regeneration 9/1096 78/18670 0.03868 0.115 0.07799 GSN/SGCA/DAG1/POSTN/GPX1/FZD7/CCNB1/NINJ1/GAP43 9 BP GO:0046626 regulation of insulin receptor signaling pathway 8/1096 66/18670 0.03869 0.115 0.07799 ENPP1/PRKCB/IL1B/PAK1/KANK1/CDK4/PTPN2/PTPRE 8 BP GO:0035303 regulation of dephosphorylation 19/1096 209/18670 0.03895 0.1157 0.07846 MAGI2/TGFB2/LILRB2/PLEK/SMAD3/ADORA1/RGN/PTPRC/CDH5/MFHAS1/MGAT5/PIN1/PINK1/DLC1/PPP1R2/NCKAP1L/PPP1R1A/CAMTA1/RIMBP2 19 BP GO:0032652 regulation of interleukin-1 production 11/1096 103/18670 0.03913 0.1161 0.07874 TNFAIP3/LPL/AIM2/SMAD3/CCR7/HSPB1/LILRA2/CX3CR1/GAS6/F2R/NLRP3 11 BP GO:0048259 regulation of receptor-mediated endocytosis 11/1096 103/18670 0.03913 0.1161 0.07874 MAGI2/ANGPT1/VEGFA/SFRP4/PLCG2/APOC1/NTF3/HIP1/USP46/SERPINE1/SNAP91 11 BP GO:0006338 chromatin remodeling 17/1096 182/18670 0.03941 0.1168 0.07923 EZH1/HMGA1/GATA3/ATRX/SMARCA1/PAK1/DAXX/SMARCD3/HDAC1/RERE/ZNHIT1/ZMIZ1/HDAC4/SATB1/JARID2/TNP2/MBD2 17 BP GO:0009166 nucleotide catabolic process 17/1096 182/18670 0.03941 0.1168 0.07923 ZBTB20/PDE1A/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/GPX1/PDE9A/HDAC4/DDIT4/NUP210/ALDOA/NUDT3 17 BP GO:0038127 ERBB signaling pathway 14/1096 142/18670 0.0396 0.1173 0.07957 TGFA/EGFR/HBEGF/PTK2B/ADORA1/BTC/PLAUR/EFEMP1/HIP1/CAMLG/LGMN/DUSP3/PTPN2/SPRY1 14 BP GO:0006869 lipid transport 30/1096 365/18670 0.03967 0.1175 0.07967 SPP1/GULP1/ATP9A/ABCC3/FABP4/ITGAV/ADIPOQ/ABCA8/UGCG/IL1B/RBP4/ABCA3/NFKBIA/HDLBP/NFKB1/GOT2/NMB/ESYT1/LIPC/NPC1/AQP9/ABCG1/SLC27A2/APOC1/STOML1/APOE/LBP/APOF/AGTR1/RXRA 30 BP GO:0006639 acylglycerol metabolic process 13/1096 129/18670 0.03981 0.1178 0.07992 LPL/FABP4/PCK1/SIK1/GK/RGN/LIPC/PNPLA4/APOC1/CAV3/GPX1/APOE/PCK2 13 BP GO:0070838 divalent metal ion transport 38/1096 483/18670 0.04076 0.1206 0.08177 PLCB1/CXCR4/CCL5/CORO1A/P2RY6/ITGAV/LILRB2/LCK/ICAM1/PRKCB/BIN1/PTK2B/STC1/CCR7/PLN/PTPN6/RGN/NOL3/CCR5/PTPRC/CASQ2/SLC39A8/LILRA2/PLCG2/GAS6/CAV3/F2R/THY1/HOMER3/SLC39A14/ATP2A1/PHB/CXCL10/SLC39A7/CXCL12/NIPAL3/CCL2/WFS1 38 BP GO:0009152 purine ribonucleotide biosynthetic process 24/1096 280/18670 0.0408 0.1206 0.08177 ZBTB20/NUPR1/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/PAPSS2/AK1/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/ADCY1 24 BP GO:0030522 intracellular receptor signaling pathway 24/1096 280/18670 0.0408 0.1206 0.08177 TNFAIP3/THRA/BIRC3/PAK1/DAXX/NFKBIA/CNOT1/BRD8/TRIP4/AR/PTPN22/PIM1/HDAC1/PHB/DHRS3/TADA3/LMO3/KAT5/IRF7/TWIST1/CARM1/SFRP1/IKBKG/RXRA 24 BP GO:0010639 negative regulation of organelle organization 32/1096 395/18670 0.04084 0.1206 0.08181 TMOD1/CORO1A/GSN/HMGA1/LILRB2/CDK10/ATRX/NUPR1/S1PR1/NOL3/SPTBN1/CDH5/PTTG1/CAPG/KANK1/ERCC1/CAV3/PINK1/CAMSAP2/BMP4/DLC1/GPX1/CCNB1/GMFG/TBC1D4/STMN2/MAP4/JARID2/TWIST1/PLK1/BNIP3/PFN2 32 BP GO:0002090 regulation of receptor internalization 7/1096 55/18670 0.04098 0.121 0.08204 MAGI2/ANGPT1/VEGFA/SFRP4/PLCG2/NTF3/USP46 7 BP GO:0030258 lipid modification 21/1096 238/18670 0.04102 0.121 0.08209 ECH1/ADIPOQ/PIP4K2B/ADIPOR2/CRAT/ECI1/ECHS1/ACADS/ABCG1/HADH/SLC27A2/APOC1/INPP5F/ACOX2/PLA2G7/APOE/TWIST1/AGTR1/INPP5D/ALDH3A2/ETFB 21 BP GO:0002040 sprouting angiogenesis 17/1096 183/18670 0.04117 0.1212 0.08222 PARVA/ANGPT1/LOXL2/SEMA5A/VEGFA/SEMA3E/AKT3/PTK2B/SMAD1/EGR3/PLK2/GATA2/BMP4/ITGA5/JMJD6/AGTR1/FLT1 17 BP GO:0009127 purine nucleoside monophosphate biosynthetic process 17/1096 183/18670 0.04117 0.1212 0.08222 ZBTB20/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/PINK1/AK1/HDAC4/DDIT4/IMPDH1/NUP210/IMPDH2/ALDOA 17 BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process 17/1096 183/18670 0.04117 0.1212 0.08222 ZBTB20/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/PINK1/AK1/HDAC4/DDIT4/IMPDH1/NUP210/IMPDH2/ALDOA 17 BP GO:0061136 regulation of proteasomal protein catabolic process 17/1096 183/18670 0.04117 0.1212 0.08222 NUPR1/RNF144A/TRIB2/PLK2/PINK1/LAMP3/GPX1/NFE2L1/CAMLG/UBE2J1/USP7/APOE/RAD23B/PLK1/USP5/HERPUD1/GLMN 17 BP GO:0016570 histone modification 36/1096 454/18670 0.04132 0.1216 0.08246 EZH1/MECP2/HUWE1/VEGFA/KAT6B/GATA3/PRKCB/PCGF2/ATRX/IL1B/AUTS2/MAPK3/BRD8/NACC2/GATA2/PAF1/PINK1/CCNA2/CCNB1/HDAC1/JMJD6/ZNHIT1/PHB/EHMT2/USP7/TADA3/FBL/MSL3/HDAC4/KAT5/SATB1/JARID2/TWIST1/CARM1/RING1/JADE2 36 BP GO:0043536 positive regulation of blood vessel endothelial cell migration 9/1096 79/18670 0.04148 0.122 0.08274 ANGPT1/VEGFA/AKT3/CD40/HSPB1/FGFR1/PLK2/GATA2/HIF1A 9 BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 11/1096 104/18670 0.04154 0.122 0.08277 TNFRSF1B/NUPR1/BCL2L2/CD44/NACC2/DYRK2/BAD/BCL2A1/DDIT4/CXCL12/IKBKE 11 BP GO:0046822 regulation of nucleocytoplasmic transport 11/1096 104/18670 0.04154 0.122 0.08277 ANGPT1/TCF7L2/IL1B/SMAD3/ZIC1/PKIG/HCLS1/GAS6/BMP4/MX2/PPM1A 11 BP GO:0106106 cold-induced thermogenesis 14/1096 143/18670 0.04163 0.1222 0.08288 NOVA1/IL4R/CXCR4/FABP4/VEGFA/ADIPOQ/THRA/ADIPOR2/HADH/ID1/UCP2/CCR2/G0S2/IL15 14 BP GO:0120161 regulation of cold-induced thermogenesis 14/1096 143/18670 0.04163 0.1222 0.08288 NOVA1/IL4R/CXCR4/FABP4/VEGFA/ADIPOQ/THRA/ADIPOR2/HADH/ID1/UCP2/CCR2/G0S2/IL15 14 BP GO:0019934 cGMP-mediated signaling 5/1096 33/18670 0.04176 0.1222 0.0829 PTK2B/AQP1/PRKG1/APOE/PDE9A 5 BP GO:0032633 interleukin-4 production 5/1096 33/18670 0.04176 0.1222 0.0829 ITK/GATA3/CD83/CD86/NLRP3 5 BP GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 5/1096 33/18670 0.04176 0.1222 0.0829 VEGFA/HSPA5/HIF1A/ATF6/MAPK7 5 BP GO:0046633 alpha-beta T cell proliferation 5/1096 33/18670 0.04176 0.1222 0.0829 IRF1/PTPRC/CCR2/ELF4/IL15 5 BP GO:0099084 postsynaptic specialization organization 5/1096 33/18670 0.04176 0.1222 0.0829 LILRB2/NTRK3/SHANK2/CDH2/GAP43 5 BP GO:0030858 positive regulation of epithelial cell differentiation 8/1096 67/18670 0.04177 0.1222 0.0829 ADIPOQ/SFRP4/CDH5/BMP4/BAD/SERPINE1/PRKCH/FOXC1 8 BP GO:0050768 negative regulation of neurogenesis 25/1096 295/18670 0.04194 0.1226 0.08312 SPP1/SEMA5A/SEMA3E/SEMA3A/NTRK3/ZNF365/IL1B/ID3/CD38/RAB29/ID1/ADCY6/PLK2/INPP5F/KANK1/SEMA3C/THY1/SEMA4F/ID4/DIO3/APOE/STMN2/BMPR1A/CARM1/COL3A1 25 BP GO:0006638 neutral lipid metabolic process 13/1096 130/18670 0.04197 0.1226 0.08312 LPL/FABP4/PCK1/SIK1/GK/RGN/LIPC/PNPLA4/APOC1/CAV3/GPX1/APOE/PCK2 13 BP GO:0007613 memory 12/1096 117/18670 0.04197 0.1226 0.08312 PLCB1/MECP2/INSR/CX3CR1/B4GALT2/PLK2/ITGA5/NTF3/APOE/NGF/LGMN/ADCY1 12 BP GO:0010906 regulation of glucose metabolic process 12/1096 117/18670 0.04197 0.1226 0.08312 FOXO1/ADIPOQ/ENPP1/SIK1/RGN/PDK2/INSR/DYRK2/NFE2L1/BAD/PHLDA2/PTPN2 12 BP GO:0042269 regulation of natural killer cell mediated cytotoxicity 6/1096 44/18670 0.04234 0.1235 0.08373 RASGRP1/CD226/SH2D1A/CRTAM/LAG3/VAV1 6 BP GO:0046189 phenol-containing compound biosynthetic process 6/1096 44/18670 0.04234 0.1235 0.08373 TGFB2/GATA3/GCH1/HDC/PNMT/MOXD1 6 BP GO:0050654 chondroitin sulfate proteoglycan metabolic process 6/1096 44/18670 0.04234 0.1235 0.08373 XYLT1/SPOCK2/CHST3/HEXA/UGDH/HYAL1 6 BP GO:1903829 positive regulation of cellular protein localization 27/1096 324/18670 0.04251 0.1239 0.08402 CD247/RAC2/HUWE1/GZMB/EPHA3/EGFR/ANK3/EPB41L2/TCF7L2/IL1B/SMAD3/GPSM2/ZIC1/PAK1/SPTBN1/RAB29/TM9SF4/HCLS1/GAS6/PINK1/BAD/PRKCH/ITGB2/PPM1A/PLK1/TENM1/PPP3CC 27 BP GO:0032373 positive regulation of sterol transport 4/1096 23/18670 0.04284 0.1244 0.08437 ADIPOQ/NFKBIA/ABCG1/APOE 4 BP GO:0032376 positive regulation of cholesterol transport 4/1096 23/18670 0.04284 0.1244 0.08437 ADIPOQ/NFKBIA/ABCG1/APOE 4 BP GO:0034123 positive regulation of toll-like receptor signaling pathway 4/1096 23/18670 0.04284 0.1244 0.08437 MFHAS1/PTPN22/TLR2/LBP 4 BP GO:0036037 CD8-positive, alpha-beta T cell activation 4/1096 23/18670 0.04284 0.1244 0.08437 RUNX3/IRF1/NCKAP1L/SATB1 4 BP GO:0043576 regulation of respiratory gaseous exchange 4/1096 23/18670 0.04284 0.1244 0.08437 FTO/MECP2/SLC5A3/ADORA1 4 BP GO:0072243 metanephric nephron epithelium development 4/1096 23/18670 0.04284 0.1244 0.08437 WWTR1/ADIPOQ/STAT1/LAMB2 4 BP GO:2000726 negative regulation of cardiac muscle cell differentiation 4/1096 23/18670 0.04284 0.1244 0.08437 PAK1/RGS2/CAV3/FZD7 4 BP GO:0043401 steroid hormone mediated signaling pathway 17/1096 184/18670 0.04299 0.1248 0.08463 THRA/PGRMC2/PAK1/DAXX/NR3C2/CNOT1/TRIP4/AR/BMP4/HDAC1/PHB/TADA3/LMO3/KAT5/CARM1/SFRP1/RXRA 17 BP GO:0060041 retina development in camera-type eye 14/1096 144/18670 0.04374 0.1269 0.08605 TGFB2/CDON/RBP4/MYH10/SMARCD3/HIF1A/THY1/DIO3/LRP5/JMJD6/LAMB2/PDGFRA/IMPDH2/COL4A1 14 BP GO:0009161 ribonucleoside monophosphate metabolic process 29/1096 354/18670 0.04407 0.1278 0.08665 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/HPRT1/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1/NUDT3 29 BP GO:0060401 cytosolic calcium ion transport 16/1096 171/18670 0.0441 0.1278 0.08667 PLCB1/CORO1A/P2RY6/LCK/PTK2B/CCR7/PLN/PTPN6/NOL3/CCR5/PTPRC/CASQ2/PLCG2/F2R/THY1/CXCL10 16 BP GO:0006911 phagocytosis, engulfment 12/1096 118/18670 0.04434 0.1284 0.0871 TRBC1/ARHGAP12/GULP1/GSN/FCGR2B/DOCK1/GATA2/IGKC/NCKAP1L/RHOBTB1/IGLC1/ITGB2 12 BP GO:0043462 regulation of ATPase activity 9/1096 80/18670 0.04441 0.1285 0.08714 TPM2/PLN/RGN/PLSCR1/ATP4B/TNNC1/MYL3/ATP2A1/PFN2 9 BP GO:0097061 dendritic spine organization 9/1096 80/18670 0.04441 0.1285 0.08714 SIPA1L1/ZNF365/FCGR2B/SHANK2/INSR/APOE/CTTN/PDLIM5/LGMN 9 BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 7/1096 56/18670 0.04456 0.1287 0.08726 RASGRP1/CD226/SH2D1A/PTPRC/CRTAM/LAG3/VAV1 7 BP GO:0006749 glutathione metabolic process 7/1096 56/18670 0.04456 0.1287 0.08726 HPGDS/GPX4/ALDH5A1/GSTA4/GPX1/NFE2L1/GSTT1 7 BP GO:0010332 response to gamma radiation 7/1096 56/18670 0.04456 0.1287 0.08726 CRYAB/GATA3/HSPA5/PTPRC/GPX1/CXCL10/CCL7 7 BP GO:1903202 negative regulation of oxidative stress-induced cell death 7/1096 56/18670 0.04456 0.1287 0.08726 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0016239 positive regulation of macroautophagy 8/1096 68/18670 0.04501 0.1292 0.08762 PIP4K2B/MAPK3/HIF1A/PINK1/PIM2/BNIP3/IKBKG/SUPT5H 8 BP GO:0031343 positive regulation of cell killing 8/1096 68/18670 0.04501 0.1292 0.08762 RASGRP1/CD226/SH2D1A/PTPRC/CRTAM/LAG3/BAD/VAV1 8 BP GO:0035914 skeletal muscle cell differentiation 8/1096 68/18670 0.04501 0.1292 0.08762 EGR2/CDON/HLF/SIX1/NUPR1/EEF2/BTG2/MAFF 8 BP GO:0071230 cellular response to amino acid stimulus 8/1096 68/18670 0.04501 0.1292 0.08762 EGFR/SIX1/XBP1/ASS1/COL1A1/PDGFRA/COL3A1/COL4A1 8 BP GO:0009132 nucleoside diphosphate metabolic process 15/1096 158/18670 0.04509 0.1292 0.08762 ZBTB20/NUPR1/PFKM/HK2/AMPD3/INSR/HIF1A/BAD/AK1/HDAC4/DDIT4/NME3/GUK1/NUP210/ALDOA 15 BP GO:0043467 regulation of generation of precursor metabolites and energy 15/1096 158/18670 0.04509 0.1292 0.08762 ZBTB20/ENPP1/NUPR1/COX7A1/INSR/TRAP1/HIF1A/DYRK2/PINK1/CCNB1/PHLDA2/HDAC4/DDIT4/NUP210/BNIP3 15 BP GO:0007501 mesodermal cell fate specification 3/1096 14/18670 0.04517 0.1292 0.08762 FGFR1/BMPR1A/HOXA11 3 BP GO:0014819 regulation of skeletal muscle contraction 3/1096 14/18670 0.04517 0.1292 0.08762 MYH7/CAV3/ATP2A1 3 BP GO:0014854 response to inactivity 3/1096 14/18670 0.04517 0.1292 0.08762 SGCA/DAG1/HDAC4 3 BP GO:0034370 triglyceride-rich lipoprotein particle remodeling 3/1096 14/18670 0.04517 0.1292 0.08762 LPL/LIPC/APOE 3 BP GO:0035112 genitalia morphogenesis 3/1096 14/18670 0.04517 0.1292 0.08762 TCF7/RBP4/AR 3 BP GO:0043173 nucleotide salvage 3/1096 14/18670 0.04517 0.1292 0.08762 ADA/AMPD3/HPRT1 3 BP GO:0045346 regulation of MHC class II biosynthetic process 3/1096 14/18670 0.04517 0.1292 0.08762 XBP1/NFX1/PF4 3 BP GO:0046629 gamma-delta T cell activation 3/1096 14/18670 0.04517 0.1292 0.08762 PTPRC/EGR3/NCKAP1L 3 BP GO:0051852 disruption by host of symbiont cells 3/1096 14/18670 0.04517 0.1292 0.08762 CXCL6/PF4/ELANE 3 BP GO:0060009 Sertoli cell development 3/1096 14/18670 0.04517 0.1292 0.08762 ICAM1/ATRX/SDC1 3 BP GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 3/1096 14/18670 0.04517 0.1292 0.08762 DYRK2/HOMER3/MAPK7 3 BP GO:0106057 negative regulation of calcineurin-mediated signaling 3/1096 14/18670 0.04517 0.1292 0.08762 DYRK2/HOMER3/MAPK7 3 BP GO:1904748 regulation of apoptotic process involved in development 3/1096 14/18670 0.04517 0.1292 0.08762 TNFRSF1B/TGFB2/FOXC1 3 BP GO:0034329 cell junction assembly 21/1096 241/18670 0.04588 0.1311 0.08894 ARL2/VEGFA/EPHA3/PTK2B/ACTN1/SMAD3/DST/TLN2/CDH5/DLG5/RAPGEF1/THY1/DLC1/ITGA5/EFNA5/PECAM1/PRKCH/CTTN/CDH2/SFRP1/DUSP3 21 BP GO:0048704 embryonic skeletal system morphogenesis 10/1096 93/18670 0.04593 0.1312 0.089 SIX1/PCGF2/SMAD3/HOXA5/BMP4/TWIST1/OSR2/PDGFRA/HOXA11/HYAL1 10 BP GO:0042177 negative regulation of protein catabolic process 13/1096 132/18670 0.04651 0.1326 0.08997 SERPINE2/EGFR/TIMP4/SMAD3/NELL1/TIMP2/PIN1/LAMP3/PHB/TIMP3/CAMLG/UBE2J1/USP7 13 BP GO:0002833 positive regulation of response to biotic stimulus 6/1096 45/18670 0.04653 0.1326 0.08997 CD226/MAPK3/LY96/CRTAM/SASH1/UNC13B 6 BP GO:0035987 endodermal cell differentiation 6/1096 45/18670 0.04653 0.1326 0.08997 ITGAV/ITGA4/PAF1/ITGA5/ITGB2/MMP15 6 BP GO:0048538 thymus development 6/1096 45/18670 0.04653 0.1326 0.08997 SIX1/GATA3/MAPK3/JARID2/PRDX2/CCNB2 6 BP GO:0010574 regulation of vascular endothelial growth factor production 5/1096 34/18670 0.04669 0.1326 0.08997 IL1B/SULF1/CCR2/HIF1A/C3AR1 5 BP GO:0010922 positive regulation of phosphatase activity 5/1096 34/18670 0.04669 0.1326 0.08997 MAGI2/PLEK/SMAD3/RGN/PTPRC 5 BP GO:0032148 activation of protein kinase B activity 5/1096 34/18670 0.04669 0.1326 0.08997 NTRK3/INSR/GAS6/PINK1/NTF3 5 BP GO:0042533 tumor necrosis factor biosynthetic process 5/1096 34/18670 0.04669 0.1326 0.08997 HSPB1/CX3CR1/CCR2/UBE2J1/LBP 5 BP GO:0042534 regulation of tumor necrosis factor biosynthetic process 5/1096 34/18670 0.04669 0.1326 0.08997 HSPB1/CX3CR1/CCR2/UBE2J1/LBP 5 BP GO:0043368 positive T cell selection 5/1096 34/18670 0.04669 0.1326 0.08997 CD3D/BATF/PTPRC/CD3G/PTPN2 5 BP GO:0045066 regulatory T cell differentiation 5/1096 34/18670 0.04669 0.1326 0.08997 LILRB2/IRF1/LILRB4/LAG3/IL2RA 5 BP GO:0051193 regulation of cofactor metabolic process 12/1096 119/18670 0.0468 0.1329 0.09013 ZBTB20/RAC2/NUPR1/PDK2/INSR/HIF1A/PINK1/ZNF205/HDAC4/DDIT4/NUP210/PRDX2 12 BP GO:0072522 purine-containing compound biosynthetic process 26/1096 313/18670 0.04732 0.1343 0.0911 ZBTB20/ADA/NUPR1/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/DCK/PAPSS2/AK1/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/ADCY1 26 BP GO:0016569 covalent chromatin modification 37/1096 474/18670 0.04737 0.1344 0.09116 EZH1/MECP2/HUWE1/VEGFA/KAT6B/GATA3/PRKCB/PCGF2/ATRX/IL1B/AUTS2/MAPK3/BRD8/NACC2/GATA2/PAF1/PINK1/CCNA2/CCNB1/HDAC1/JMJD6/ZNHIT1/PHB/EHMT2/USP7/TADA3/FBL/MSL3/HDAC4/KAT5/SATB1/JARID2/TWIST1/CARM1/RING1/JADE2/MBD2 37 BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 9/1096 81/18670 0.04747 0.1344 0.09117 TGFBR3/SMAD3/HSPA5/PIN1/LDLRAD4/HTRA1/PPM1A/SMAD6/ADAMTSL2 9 BP GO:0048708 astrocyte differentiation 9/1096 81/18670 0.04747 0.1344 0.09117 SERPINE2/EGFR/NTRK3/BIN1/IL1B/MAPK3/ID4/TSPAN2/LAMB2 9 BP GO:0060761 negative regulation of response to cytokine stimulus 9/1096 81/18670 0.04747 0.1344 0.09117 CCL5/ADIPOQ/PXDN/IL1RN/NOL3/PTPRC/GAS6/MAPK7/PTPN2 9 BP GO:1902930 regulation of alcohol biosynthetic process 9/1096 81/18670 0.04747 0.1344 0.09117 P2RY6/PTK2B/IL1B/PLEK/NFKB1/PTAFR/ABCG1/PMVK/APOE 9 BP GO:0009144 purine nucleoside triphosphate metabolic process 28/1096 342/18670 0.04751 0.1344 0.09119 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NME3/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1 28 BP GO:0072511 divalent inorganic cation transport 38/1096 489/18670 0.04754 0.1345 0.0912 PLCB1/CXCR4/CCL5/CORO1A/P2RY6/ITGAV/LILRB2/LCK/ICAM1/PRKCB/BIN1/PTK2B/STC1/CCR7/PLN/PTPN6/RGN/NOL3/CCR5/PTPRC/CASQ2/SLC39A8/LILRA2/PLCG2/GAS6/CAV3/F2R/THY1/HOMER3/SLC39A14/ATP2A1/PHB/CXCL10/SLC39A7/CXCL12/NIPAL3/CCL2/WFS1 38 BP GO:0050819 negative regulation of coagulation 7/1096 57/18670 0.04833 0.1365 0.09259 SERPINE2/TFPI/PLAUR/PRKG1/APOE/SERPINE1/PDGFRA 7 BP GO:0060043 regulation of cardiac muscle cell proliferation 7/1096 57/18670 0.04833 0.1365 0.09259 TGFBR3/RBP4/FGFR1/PIM1/CCNB1/BMPR1A/JARID2 7 BP GO:1900408 negative regulation of cellular response to oxidative stress 7/1096 57/18670 0.04833 0.1365 0.09259 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0051289 protein homotetramerization 10/1096 94/18670 0.04882 0.1377 0.09343 CD247/GPX3/PFKM/HPRT1/ALDH5A1/PCBD1/CBY1/IMPDH2/RXRA/ALDOA 10 BP GO:0060993 kidney morphogenesis 10/1096 94/18670 0.04882 0.1377 0.09343 WWTR1/VEGFA/SIX1/GATA3/MAGED1/BMP4/BASP1/STAT1/CTNNBIP1/HOXA11 10 BP GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 4/1096 24/18670 0.0491 0.1382 0.09374 ADIPOQ/NOL3/GAS6/PTPN2 4 BP GO:0045606 positive regulation of epidermal cell differentiation 4/1096 24/18670 0.0491 0.1382 0.09374 SFRP4/BMP4/PRKCH/FOXC1 4 BP GO:0051446 positive regulation of meiotic cell cycle 4/1096 24/18670 0.0491 0.1382 0.09374 PLCB1/CDC25B/INSR/LFNG 4 BP GO:1903020 positive regulation of glycoprotein metabolic process 4/1096 24/18670 0.0491 0.1382 0.09374 PLCB1/TCF7L2/CCR7/IL15 4 BP GO:2000178 negative regulation of neural precursor cell proliferation 4/1096 24/18670 0.0491 0.1382 0.09374 BTG2/GATA2/RAPGEF1/SPINT2 4 BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 12/1096 120/18670 0.04934 0.1388 0.09415 TGFBR3/SMAD3/HSPA5/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/HTRA1/PPM1A/SMAD6/ADAMTSL2 12 BP GO:0006164 purine nucleotide biosynthetic process 25/1096 300/18670 0.04944 0.139 0.09428 ZBTB20/ADA/NUPR1/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/PAPSS2/AK1/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/ADCY1 25 BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 9/1096 82/18670 0.05067 0.1423 0.09655 CORO1A/P2RY6/PTK2B/PLN/PTPN6/CASQ2/F2R/THY1/CXCL10 9 BP GO:1905954 positive regulation of lipid localization 9/1096 82/18670 0.05067 0.1423 0.09655 SPP1/LPL/ADIPOQ/IL1B/NFKBIA/NFKB1/ABCG1/APOE/IKBKE 9 BP GO:0002715 regulation of natural killer cell mediated immunity 6/1096 46/18670 0.05097 0.1428 0.09686 RASGRP1/CD226/SH2D1A/CRTAM/LAG3/VAV1 6 BP GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 6/1096 46/18670 0.05097 0.1428 0.09686 ICAM1/ITGAL/ITGA5/CDH2/TENM1/SELP 6 BP GO:0032480 negative regulation of type I interferon production 6/1096 46/18670 0.05097 0.1428 0.09686 TNFAIP3/RELB/PIN1/NMI/PCBP2/IKBKE 6 BP GO:0050706 regulation of interleukin-1 beta secretion 6/1096 46/18670 0.05097 0.1428 0.09686 TNFAIP3/LPL/AIM2/CCR7/LILRA2/NLRP3 6 BP GO:0071354 cellular response to interleukin-6 6/1096 46/18670 0.05097 0.1428 0.09686 ICAM1/SELPLG/NFKB1/PHB/STAT1/PTPN2 6 BP GO:0035967 cellular response to topologically incorrect protein 15/1096 161/18670 0.05165 0.1447 0.09811 CREB3L2/DAXX/XBP1/CXCL8/CCND1/HSPA5/GFPT1/ATF6/KDELR3/PTPN2/CCL2/WFS1/TSPYL2/ATP6V0D1/HERPUD1 15 BP GO:0061326 renal tubule development 10/1096 95/18670 0.05182 0.1449 0.09828 WWTR1/VEGFA/SIX1/GATA3/MAGED1/BMP4/STAT1/CTNNBIP1/HOXA11/COL4A1 10 BP GO:0001893 maternal placenta development 5/1096 35/18670 0.05194 0.1449 0.09828 SPP1/STC1/MAPK3/LDOC1/RXRA 5 BP GO:0019433 triglyceride catabolic process 5/1096 35/18670 0.05194 0.1449 0.09828 LPL/FABP4/LIPC/PNPLA4/APOE 5 BP GO:0035909 aorta morphogenesis 5/1096 35/18670 0.05194 0.1449 0.09828 TGFB2/SIX1/BMPR1A/NPRL3/COL3A1 5 BP GO:0048333 mesodermal cell differentiation 5/1096 35/18670 0.05194 0.1449 0.09828 SMAD1/FGFR1/BMP4/BMPR1A/HOXA11 5 BP GO:0060338 regulation of type I interferon-mediated signaling pathway 5/1096 35/18670 0.05194 0.1449 0.09828 IFNAR2/PTPN6/IRF7/PTPN2/IKBKE 5 BP GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 5/1096 35/18670 0.05194 0.1449 0.09828 TNFAIP3/BIRC3/NFKBIA/PTPN22/IKBKG 5 BP GO:0097484 dendrite extension 5/1096 35/18670 0.05194 0.1449 0.09828 CXCR4/AUTS2/NEDD4L/SYT17/CYFIP2 5 BP GO:0002709 regulation of T cell mediated immunity 8/1096 70/18670 0.05197 0.1449 0.09829 TNFRSF1B/IL7R/GATA3/FCGR2B/IL1B/PTPRC/CCR2/NLRP3 8 BP GO:0009314 response to radiation 35/1096 448/18670 0.05207 0.1451 0.09843 MECP2/CRYAB/EGFR/ADIRF/ICAM1/MFAP4/GATA3/CIRBP/NAMPT/TP53BP1/SIK1/MAP3K4/GNA11/CCND1/HSPA5/PTPRC/B4GALT2/ERCC1/HIF1A/GPX1/AQP1/UBE4B/MAPK10/CXCL10/KAT5/MAPK13/CXCL12/SFRP1/ANGPT2/EEF1D/COL3A1/ELANE/CCL7/HYAL1/JUN 35 BP GO:0006275 regulation of DNA replication 11/1096 108/18670 0.05219 0.1454 0.0986 EGFR/ZNF365/ATRX/ID3/FGFR1/TNFAIP1/CCNA2/EHMT2/TSPYL2/CDC6/JUN 11 BP GO:0019229 regulation of vasoconstriction 7/1096 58/18670 0.05231 0.1455 0.09868 EGFR/ICAM1/PTAFR/CD38/F2R/AGTR1/CHRM3 7 BP GO:0042093 T-helper cell differentiation 7/1096 58/18670 0.05231 0.1455 0.09868 IL4R/RELB/GATA3/GPR183/BATF/CD86/NLRP3 7 BP GO:1904589 regulation of protein import 7/1096 58/18670 0.05231 0.1455 0.09868 ANGPT1/SMAD3/ZIC1/PKIG/HCLS1/BMP4/ARHGEF5 7 BP GO:0051494 negative regulation of cytoskeleton organization 14/1096 148/18670 0.0529 0.147 0.0997 TMOD1/CORO1A/GSN/S1PR1/SPTBN1/CDH5/CAPG/KANK1/CAV3/CAMSAP2/DLC1/GMFG/STMN2/PFN2 14 BP GO:0051592 response to calcium ion 14/1096 148/18670 0.0529 0.147 0.0997 EGFR/PTK2B/CPNE1/SDC1/ANXA11/CCND1/HSPA5/CASQ2/SYT17/TTN/BAD/LGMN/JUN/ADCY1 14 BP GO:0006816 calcium ion transport 34/1096 434/18670 0.0532 0.1475 0.1001 PLCB1/CXCR4/CCL5/CORO1A/P2RY6/ITGAV/LILRB2/LCK/ICAM1/PRKCB/BIN1/PTK2B/STC1/CCR7/PLN/PTPN6/RGN/NOL3/CCR5/PTPRC/CASQ2/LILRA2/PLCG2/GAS6/CAV3/F2R/THY1/HOMER3/ATP2A1/PHB/CXCL10/CXCL12/CCL2/WFS1 34 BP GO:0010324 membrane invagination 13/1096 135/18670 0.05395 0.1475 0.1001 TRBC1/ARHGAP12/GULP1/GSN/FNBP1L/FCGR2B/DOCK1/GATA2/IGKC/NCKAP1L/RHOBTB1/IGLC1/ITGB2 13 BP GO:0071331 cellular response to hexose stimulus 13/1096 135/18670 0.05395 0.1475 0.1001 ZBTB20/PCK1/ICAM1/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/SLC2A5/BAD/PCK2 13 BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 9/1096 83/18670 0.05402 0.1475 0.1001 CCL5/CD40/HCLS1/INPP5F/PECAM1/PTPN2/FGFR3/CRLF1/IL15 9 BP GO:1901879 regulation of protein depolymerization 9/1096 83/18670 0.05402 0.1475 0.1001 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/ASPH/CAPG/CAMSAP2/STMN2 9 BP GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 9/1096 83/18670 0.05402 0.1475 0.1001 TGFBR3/SMAD3/HSPA5/PIN1/LDLRAD4/HTRA1/PPM1A/SMAD6/ADAMTSL2 9 BP GO:0015671 oxygen transport 3/1096 15/18670 0.05407 0.1475 0.1001 HBB/MB/HBE1 3 BP GO:0018158 protein oxidation 3/1096 15/18670 0.05407 0.1475 0.1001 LOXL2/GPX1/LOXL1 3 BP GO:0030238 male sex determination 3/1096 15/18670 0.05407 0.1475 0.1001 MAP3K4/INSR/AR 3 BP GO:0030730 sequestering of triglyceride 3/1096 15/18670 0.05407 0.1475 0.1001 LPL/ENPP1/IL1B 3 BP GO:0030812 negative regulation of nucleotide catabolic process 3/1096 15/18670 0.05407 0.1475 0.1001 NUPR1/HDAC4/DDIT4 3 BP GO:0032352 positive regulation of hormone metabolic process 3/1096 15/18670 0.05407 0.1475 0.1001 GATA3/IL1B/HIF1A 3 BP GO:0032486 Rap protein signal transduction 3/1096 15/18670 0.05407 0.1475 0.1001 TIMP2/PLK2/RAPGEF1 3 BP GO:0032736 positive regulation of interleukin-13 production 3/1096 15/18670 0.05407 0.1475 0.1001 GATA3/IL17RA/NLRP3 3 BP GO:0033689 negative regulation of osteoblast proliferation 3/1096 15/18670 0.05407 0.1475 0.1001 SMAD3/NELL1/SFRP1 3 BP GO:0034134 toll-like receptor 2 signaling pathway 3/1096 15/18670 0.05407 0.1475 0.1001 TNFAIP3/MFHAS1/TLR2 3 BP GO:0034349 glial cell apoptotic process 3/1096 15/18670 0.05407 0.1475 0.1001 GAS6/PRKCH/CCL2 3 BP GO:0034616 response to laminar fluid shear stress 3/1096 15/18670 0.05407 0.1475 0.1001 ASS1/MAPK7/SMAD6 3 BP GO:0042159 lipoprotein catabolic process 3/1096 15/18670 0.05407 0.1475 0.1001 CTSD/APOE/LYPLA1 3 BP GO:0042559 pteridine-containing compound biosynthetic process 3/1096 15/18670 0.05407 0.1475 0.1001 GCH1/PCBD1/QDPR 3 BP GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 3/1096 15/18670 0.05407 0.1475 0.1001 CD44/TWIST1/PTTG1IP 3 BP GO:0044406 adhesion of symbiont to host 3/1096 15/18670 0.05407 0.1475 0.1001 ICAM1/GAS6/INHBB 3 BP GO:0045342 MHC class II biosynthetic process 3/1096 15/18670 0.05407 0.1475 0.1001 XBP1/NFX1/PF4 3 BP GO:0048569 post-embryonic animal organ development 3/1096 15/18670 0.05407 0.1475 0.1001 VEGFA/ERCC1/EFEMP1 3 BP GO:0050961 detection of temperature stimulus involved in sensory perception 3/1096 15/18670 0.05407 0.1475 0.1001 CXCR4/ADORA1/CXCL12 3 BP GO:0050965 detection of temperature stimulus involved in sensory perception of pain 3/1096 15/18670 0.05407 0.1475 0.1001 CXCR4/ADORA1/CXCL12 3 BP GO:0051198 negative regulation of coenzyme metabolic process 3/1096 15/18670 0.05407 0.1475 0.1001 NUPR1/HDAC4/DDIT4 3 BP GO:0060766 negative regulation of androgen receptor signaling pathway 3/1096 15/18670 0.05407 0.1475 0.1001 HDAC1/PHB/SFRP1 3 BP GO:0070571 negative regulation of neuron projection regeneration 3/1096 15/18670 0.05407 0.1475 0.1001 SPP1/INPP5F/THY1 3 BP GO:0071801 regulation of podosome assembly 3/1096 15/18670 0.05407 0.1475 0.1001 GSN/LCP1/ARHGEF5 3 BP GO:0072075 metanephric mesenchyme development 3/1096 15/18670 0.05407 0.1475 0.1001 SIX1/BASP1/STAT1 3 BP GO:0072160 nephron tubule epithelial cell differentiation 3/1096 15/18670 0.05407 0.1475 0.1001 WWTR1/GATA3/STAT1 3 BP GO:0090197 positive regulation of chemokine secretion 3/1096 15/18670 0.05407 0.1475 0.1001 IL4R/LPL/POSTN 3 BP GO:1903358 regulation of Golgi organization 3/1096 15/18670 0.05407 0.1475 0.1001 MAPK3/AKAP9/CAMSAP2 3 BP GO:1903729 regulation of plasma membrane organization 3/1096 15/18670 0.05407 0.1475 0.1001 TGFB2/GSN/AR 3 BP GO:1905874 regulation of postsynaptic density organization 3/1096 15/18670 0.05407 0.1475 0.1001 LILRB2/NTRK3/CDH2 3 BP GO:2000402 negative regulation of lymphocyte migration 3/1096 15/18670 0.05407 0.1475 0.1001 CD200/IL27RA/CCL2 3 BP GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 3/1096 15/18670 0.05407 0.1475 0.1001 RUNX3/IRF1/NCKAP1L 3 BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 12/1096 122/18670 0.05473 0.1492 0.1012 TGFBR3/SMAD3/HSPA5/CAV3/PIN1/LTBP4/LDLRAD4/GOT1/HTRA1/PPM1A/SMAD6/ADAMTSL2 12 BP GO:0008585 female gonad development 10/1096 96/18670 0.05495 0.1497 0.1015 VEGFA/ICAM1/NUPR1/HSPA5/INSR/LFNG/FOXC1/SFRP1/PDGFRA/INHBB 10 BP GO:0042632 cholesterol homeostasis 10/1096 96/18670 0.05495 0.1497 0.1015 LPL/FABP4/XBP1/LIPC/NPC1/ABCG1/CAV3/NFE2L1/LRP5/APOE 10 BP GO:0002832 negative regulation of response to biotic stimulus 6/1096 47/18670 0.05565 0.1512 0.1025 TNFAIP3/LILRA2/PCBP2/HTRA1/IL2RA/PRDX2 6 BP GO:0014911 positive regulation of smooth muscle cell migration 6/1096 47/18670 0.05565 0.1512 0.1025 CCL5/P2RY6/POSTN/PAK1/IGFBP5/HDAC4 6 BP GO:0021695 cerebellar cortex development 6/1096 47/18670 0.05565 0.1512 0.1025 SERPINE2/ZNF365/MYH10/HSPA5/B4GALT2/RERE 6 BP GO:0031952 regulation of protein autophosphorylation 6/1096 47/18670 0.05565 0.1512 0.1025 VEGFA/ADIPOQ/ENPP1/GFRA2/PTPRC/JUN 6 BP GO:1901068 guanosine-containing compound metabolic process 6/1096 47/18670 0.05565 0.1512 0.1025 AMPD3/HPRT1/NME3/GUK1/IMPDH1/IMPDH2 6 BP GO:1903580 positive regulation of ATP metabolic process 6/1096 47/18670 0.05565 0.1512 0.1025 ZBTB20/NUPR1/INSR/HIF1A/PINK1/CCNB1 6 BP GO:0002507 tolerance induction 4/1096 25/18670 0.05584 0.1512 0.1025 TNFAIP3/PHLPP1/LILRB2/IL2RA 4 BP GO:0021680 cerebellar Purkinje cell layer development 4/1096 25/18670 0.05584 0.1512 0.1025 MYH10/HSPA5/B4GALT2/RERE 4 BP GO:0045830 positive regulation of isotype switching 4/1096 25/18670 0.05584 0.1512 0.1025 CD40/TP53BP1/PTPRC/TFRC 4 BP GO:0048103 somatic stem cell division 4/1096 25/18670 0.05584 0.1512 0.1025 SOX5/TGFB2/FGFR1/FZD7 4 BP GO:0051894 positive regulation of focal adhesion assembly 4/1096 25/18670 0.05584 0.1512 0.1025 VEGFA/SMAD3/THY1/SFRP1 4 BP GO:0060561 apoptotic process involved in morphogenesis 4/1096 25/18670 0.05584 0.1512 0.1025 TNFRSF1B/CRYAB/TGFB2/FOXC1 4 BP GO:0061050 regulation of cell growth involved in cardiac muscle cell development 4/1096 25/18670 0.05584 0.1512 0.1025 PAK1/RGS2/CAV3/PIN1 4 BP GO:0097479 synaptic vesicle localization 15/1096 163/18670 0.05638 0.1526 0.1035 MAGI2/STXBP1/STX11/PRKCB/RAB27A/DNM1/SYT17/PINK1/UNC13B/PCDH17/RIMS3/SNAP91/CDH2/PFN2/ADCY1 15 BP GO:0021885 forebrain cell migration 7/1096 59/18670 0.05648 0.1526 0.1035 CXCR4/EGFR/AXL/SEMA3A/CXCL12/NRP2/TYRO3 7 BP GO:0042130 negative regulation of T cell proliferation 7/1096 59/18670 0.05648 0.1526 0.1035 LILRB2/PTPN6/DLG5/BMP4/CD86/IL2RA/GLMN 7 BP GO:1902883 negative regulation of response to oxidative stress 7/1096 59/18670 0.05648 0.1526 0.1035 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0046939 nucleotide phosphorylation 13/1096 136/18670 0.0566 0.1528 0.1036 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/AK1/HDAC4/DDIT4/NME3/GUK1/NUP210/ALDOA 13 BP GO:0071326 cellular response to monosaccharide stimulus 13/1096 136/18670 0.0566 0.1528 0.1036 ZBTB20/PCK1/ICAM1/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/SLC2A5/BAD/PCK2 13 BP GO:0007416 synapse assembly 16/1096 177/18670 0.05702 0.1539 0.1044 MAGI2/MECP2/SPOCK2/CLSTN1/SIX1/NTRK3/THBS2/SHANK2/RAB29/DLG5/EFNA5/TLR2/PCDH17/PDLIM5/CDH2/GAP43 16 BP GO:0016358 dendrite development 20/1096 233/18670 0.05717 0.1542 0.1046 SIPA1L1/MECP2/SEMA3A/DCLK1/ZNF365/CUX1/SHANK2/NEDD4L/ID1/PAK2/HPRT1/DLG5/PLK2/CAMSAP2/RERE/PRKG1/APOE/PDLIM5/CARM1/COBL 20 BP GO:0042594 response to starvation 17/1096 191/18670 0.05737 0.1544 0.1047 FOXO1/PCK1/XBP1/MAPK3/SIK1/DAP/HSPA5/GABARAPL1/OXCT1/GAS6/EHMT2/WDR45/SFRP1/NPRL3/INHBB/PCK2/JUN 17 BP GO:0097756 negative regulation of blood vessel diameter 9/1096 84/18670 0.0575 0.1544 0.1047 EGFR/ICAM1/ADORA1/PTAFR/CD38/ACTA2/F2R/AGTR1/CHRM3 9 BP GO:0006007 glucose catabolic process 5/1096 36/18670 0.05753 0.1544 0.1047 PFKM/HK2/LRP5/BAD/ALDOA 5 BP GO:0010453 regulation of cell fate commitment 5/1096 36/18670 0.05753 0.1544 0.1047 AR/FGFR1/BMP4/FZD7/BMPR1A 5 BP GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 5/1096 36/18670 0.05753 0.1544 0.1047 TNFAIP3/BIRC3/NFKBIA/PTPN22/IKBKG 5 BP GO:0045740 positive regulation of DNA replication 5/1096 36/18670 0.05753 0.1544 0.1047 EGFR/ATRX/FGFR1/TNFAIP1/JUN 5 BP GO:0060428 lung epithelium development 5/1096 36/18670 0.05753 0.1544 0.1047 NFIB/THRA/HOXA5/BMP4/ADAMTSL2 5 BP GO:0071392 cellular response to estradiol stimulus 5/1096 36/18670 0.05753 0.1544 0.1047 EGFR/BCL2L2/CCNA2/KAT5/SFRP1 5 BP GO:0071634 regulation of transforming growth factor beta production 5/1096 36/18670 0.05753 0.1544 0.1047 TGFB2/ITGAV/CD200/SMAD3/HIF1A 5 BP GO:0090322 regulation of superoxide metabolic process 5/1096 36/18670 0.05753 0.1544 0.1047 EGFR/GCH1/RGN/FBLN5/ITGB2 5 BP GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 5/1096 36/18670 0.05753 0.1544 0.1047 IL4R/CD83/NCKAP1L/CD86/NLRP3 5 BP GO:0009116 nucleoside metabolic process 12/1096 123/18670 0.05756 0.1544 0.1047 ADA/AMPD3/HPRT1/DCK/AHCY/NME3/GUK1/IMPDH1/IMPDH2/TYMP/TK2/AHCYL2 12 BP GO:0032231 regulation of actin filament bundle assembly 10/1096 97/18670 0.0582 0.1559 0.1058 ARHGEF10/PLEK/SMAD3/PAK1/S1PR1/ID1/DLC1/ARHGEF5/SFRP1/PFN2 10 BP GO:0055092 sterol homeostasis 10/1096 97/18670 0.0582 0.1559 0.1058 LPL/FABP4/XBP1/LIPC/NPC1/ABCG1/CAV3/NFE2L1/LRP5/APOE 10 BP GO:0015850 organic hydroxy compound transport 22/1096 262/18670 0.05823 0.1559 0.1058 SPP1/MECP2/ABCC3/ADIPOQ/SLC5A3/RBP4/NFKBIA/NFKB1/LIPC/NPC1/AQP9/ABCG1/SYT17/APOC1/PINK1/AQP1/SNCG/APOE/CXCL12/AGTR1/RXRA/SLC18A2 22 BP GO:0006633 fatty acid biosynthetic process 15/1096 164/18670 0.05885 0.1575 0.1068 LPL/LTC4S/PTGS1/HPGDS/ADIPOQ/IL1B/GPX4/ADIPOR2/XBP1/RGN/TECR/LIPC/APOC1/PTGDS/ALOX5 15 BP GO:0046425 regulation of JAK-STAT cascade 13/1096 137/18670 0.05934 0.1588 0.1077 CCL5/PTK2B/CD40/AKR1B1/PTPRC/HCLS1/INPP5F/F2R/PECAM1/PTPN2/FGFR3/CRLF1/IL15 13 BP GO:0009205 purine ribonucleoside triphosphate metabolic process 27/1096 335/18670 0.05944 0.159 0.1078 ZBTB20/MECP2/ENPP1/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NME3/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1 27 BP GO:0002532 production of molecular mediator involved in inflammatory response 8/1096 72/18670 0.05959 0.1591 0.1079 IL4R/GPSM3/MYD88/IL17RA/SERPINE1/LBP/ALOX5/PRDX2 8 BP GO:0032272 negative regulation of protein polymerization 8/1096 72/18670 0.05959 0.1591 0.1079 TMOD1/GSN/SPTBN1/CDH5/CAPG/KANK1/STMN2/PFN2 8 BP GO:0061180 mammary gland epithelium development 8/1096 72/18670 0.05959 0.1591 0.1079 GATA3/CCND1/AR/CAV3/HOXA5/HIF1A/GPX1/LRP5 8 BP GO:0051648 vesicle localization 25/1096 306/18670 0.05965 0.1592 0.108 MAGI2/TGFA/STXBP1/STX11/RASGRP1/FNBP1L/SERPINA1/PRKCB/KIF3B/RAB27A/CTSC/ITGA4/DNM1/SYT17/PINK1/UNC13B/F8/PCDH17/RIMS3/SNAP91/DCTN2/CDH2/PFN2/IKBKG/ADCY1 25 BP GO:0055088 lipid homeostasis 14/1096 151/18670 0.06058 0.1614 0.1095 ZBTB20/LPL/FABP4/XBP1/ADORA1/LIPC/NPC1/ABCG1/CAV3/ACOX2/GOT1/NFE2L1/LRP5/APOE 14 BP GO:1903169 regulation of calcium ion transmembrane transport 14/1096 151/18670 0.06058 0.1614 0.1095 CORO1A/P2RY6/BIN1/PTK2B/PLN/PTPN6/RGN/CASQ2/PLCG2/CAV3/F2R/THY1/ATP2A1/CXCL10 14 BP GO:0030850 prostate gland development 6/1096 48/18670 0.06059 0.1614 0.1095 SULF1/AR/ID4/BMP4/SFRP1/RXRA 6 BP GO:0055023 positive regulation of cardiac muscle tissue growth 6/1096 48/18670 0.06059 0.1614 0.1095 TGFBR3/FGFR1/PIN1/PIM1/CCNB1/BMPR1A 6 BP GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 7/1096 60/18670 0.06085 0.162 0.1099 IL4R/RELB/GATA3/GPR183/BATF/CD86/NLRP3 7 BP GO:0009798 axis specification 9/1096 85/18670 0.06112 0.1625 0.1102 STC1/BMP4/ETS2/BASP1/BMPR1A/SFRP1/COBL/SMAD6/STIL 9 BP GO:0050772 positive regulation of axonogenesis 9/1096 85/18670 0.06112 0.1625 0.1102 SEMA5A/VEGFA/NTRK3/PAK1/EFNA5/NGF/PLXNC1/PLXNA2/CXCL12 9 BP GO:1903901 negative regulation of viral life cycle 9/1096 85/18670 0.06112 0.1625 0.1102 FCN1/CCL5/GSN/SLPI/MID2/PLSCR1/ISG20/APCS/VAPA 9 BP GO:0031124 mRNA 3'-end processing 10/1096 98/18670 0.06157 0.1637 0.111 SNRPA/DDX39A/PAF1/CCNB1/SLBP/SCAF8/CDC40/CASC3/POLDIP3/SUPT5H 10 BP GO:0019216 regulation of lipid metabolic process 32/1096 410/18670 0.06166 0.1638 0.1111 ZBTB20/RARRES2/ADIPOQ/CHD9/THRA/PTK2B/IL1B/ADIPOR2/CCR7/IGFBP7/ADORA1/SIK1/RGN/NFKB1/PDK2/ABCG1/APOC1/SMARCD3/G0S2/CDK4/EEF1A2/NFE2L1/PMVK/APOE/RGL1/TWIST1/AGTR1/CARM1/FGFR3/PDGFRA/RXRA/FLT1 32 BP GO:0030073 insulin secretion 18/1096 207/18670 0.06198 0.1646 0.1116 CCL5/ARL2/IL1RN/TCF7L2/IL1B/RBP4/CD38/ICA1/HADH/OXCT1/HIF1A/EFNA5/LRP5/BAD/SLC25A4/SFRP1/INHBB/NNAT 18 BP GO:0002377 immunoglobulin production 17/1096 193/18670 0.06203 0.1647 0.1117 IL4R/IL7R/CD40/FCGR2B/TP53BP1/RBP4/XBP1/IL27RA/BATF/PTPRC/ERCC1/PARP3/TNFRSF4/IGKC/CCR6/IGLV6-57/TFRC 17 BP GO:0009260 ribonucleotide biosynthetic process 24/1096 293/18670 0.06246 0.1654 0.1122 ZBTB20/NUPR1/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/PAPSS2/AK1/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/ADCY1 24 BP GO:0006817 phosphate ion transport 4/1096 26/18670 0.06305 0.1654 0.1122 SFRP4/SLC20A1/FGFR1/SLC20A2 4 BP GO:0022011 myelination in peripheral nervous system 4/1096 26/18670 0.06305 0.1654 0.1122 NDRG1/NTRK3/ARHGEF10/DAG1 4 BP GO:0032292 peripheral nervous system axon ensheathment 4/1096 26/18670 0.06305 0.1654 0.1122 NDRG1/NTRK3/ARHGEF10/DAG1 4 BP GO:0042745 circadian sleep/wake cycle 4/1096 26/18670 0.06305 0.1654 0.1122 ADA/ADORA1/AHCY/PTGDS 4 BP GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 4/1096 26/18670 0.06305 0.1654 0.1122 AR/IGFBP6/IGFBP2/IGFBP5 4 BP GO:0051125 regulation of actin nucleation 4/1096 26/18670 0.06305 0.1654 0.1122 CORO1A/GSN/GMFG/NCKAP1 4 BP GO:0070911 global genome nucleotide-excision repair 4/1096 26/18670 0.06305 0.1654 0.1122 ERCC1/CETN2/RAD23B/CUL4A 4 BP GO:0097066 response to thyroid hormone 4/1096 26/18670 0.06305 0.1654 0.1122 SIX1/AKR1B1/CTSL/CTSH 4 BP GO:0099560 synaptic membrane adhesion 4/1096 26/18670 0.06305 0.1654 0.1122 SPARCL1/EFNA5/PCDH17/PTPRF 4 BP GO:1900120 regulation of receptor binding 4/1096 26/18670 0.06305 0.1654 0.1122 ADIPOQ/LDOC1/PHLDA2/PTPRF 4 BP GO:1904353 regulation of telomere capping 4/1096 26/18670 0.06305 0.1654 0.1122 MAPK3/MAP3K4/ERCC1/USP7 4 BP GO:0000187 activation of MAPK activity 14/1096 152/18670 0.0633 0.1654 0.1122 CXCR4/TGFA/DUSP5/NTRK3/IL1B/DAXX/MAPK3/PTPRC/INSR/MAP4K1/NTF3/MAPK10/IKBKG/PRDX2 14 BP GO:0001678 cellular glucose homeostasis 14/1096 152/18670 0.0633 0.1654 0.1122 FOXO1/ZBTB20/PCK1/ICAM1/HK2/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/BAD/PCK2 14 BP GO:0002714 positive regulation of B cell mediated immunity 5/1096 37/18670 0.06344 0.1654 0.1122 CD226/CD40/TP53BP1/PTPRC/TFRC 5 BP GO:0002891 positive regulation of immunoglobulin mediated immune response 5/1096 37/18670 0.06344 0.1654 0.1122 CD226/CD40/TP53BP1/PTPRC/TFRC 5 BP GO:0014912 negative regulation of smooth muscle cell migration 5/1096 37/18670 0.06344 0.1654 0.1122 ADIPOQ/IGFBP5/PRKG1/SERPINE1/BMPR1A 5 BP GO:0034405 response to fluid shear stress 5/1096 37/18670 0.06344 0.1654 0.1122 PTK2B/ASS1/MAPK7/TFPI2/SMAD6 5 BP GO:0043029 T cell homeostasis 5/1096 37/18670 0.06344 0.1654 0.1122 CORO1A/NCKAP1L/TNFSF14/IL2RA/CCNB2 5 BP GO:0043243 positive regulation of protein complex disassembly 5/1096 37/18670 0.06344 0.1654 0.1122 SEMA5A/PLEK/INSR/STMN2/BNIP3 5 BP GO:0050691 regulation of defense response to virus by host 5/1096 37/18670 0.06344 0.1654 0.1122 TNFAIP3/AIM2/IL1B/STAT1/IL15 5 BP GO:2000273 positive regulation of signaling receptor activity 5/1096 37/18670 0.06344 0.1654 0.1122 TGFA/ADORA1/CCR2/PINK1/CCL2 5 BP GO:0030326 embryonic limb morphogenesis 12/1096 125/18670 0.06351 0.1654 0.1122 ZBTB16/HOXA10/TGFB2/PITX1/FGFR1/BMP4/B9D1/HDAC1/BMPR1A/TWIST1/OSR2/HOXA11 12 BP GO:0035113 embryonic appendage morphogenesis 12/1096 125/18670 0.06351 0.1654 0.1122 ZBTB16/HOXA10/TGFB2/PITX1/FGFR1/BMP4/B9D1/HDAC1/BMPR1A/TWIST1/OSR2/HOXA11 12 BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 12/1096 125/18670 0.06351 0.1654 0.1122 BTG2/CCND1/CNOT1/CDKN2C/NACC2/PLK2/CDK4/CCNB1/CNOT4/CARM1/CCL2/FHL1 12 BP GO:0060350 endochondral bone morphogenesis 8/1096 73/18670 0.06365 0.1654 0.1122 STC1/ALPL/COL1A1/BMP4/FOXC1/CARM1/FGFR3/HOXA11 8 BP GO:0002070 epithelial cell maturation 3/1096 16/18670 0.06374 0.1654 0.1122 XBP1/HOXA5/HIF1A 3 BP GO:0002643 regulation of tolerance induction 3/1096 16/18670 0.06374 0.1654 0.1122 PHLPP1/LILRB2/IL2RA 3 BP GO:0002739 regulation of cytokine secretion involved in immune response 3/1096 16/18670 0.06374 0.1654 0.1122 TNFRSF1B/ANGPT1/MAPK3 3 BP GO:0003222 ventricular trabecula myocardium morphogenesis 3/1096 16/18670 0.06374 0.1654 0.1122 TGFB2/UBE4B/BMPR1A 3 BP GO:0007567 parturition 3/1096 16/18670 0.06374 0.1654 0.1122 PTAFR/LDOC1/MAFF 3 BP GO:0030214 hyaluronan catabolic process 3/1096 16/18670 0.06374 0.1654 0.1122 CD44/HEXA/HYAL1 3 BP GO:0032604 granulocyte macrophage colony-stimulating factor production 3/1096 16/18670 0.06374 0.1654 0.1122 RASGRP1/IL1B/LILRA2 3 BP GO:0033033 negative regulation of myeloid cell apoptotic process 3/1096 16/18670 0.06374 0.1654 0.1122 CCL5/CCR5/IRF7 3 BP GO:0035372 protein localization to microtubule 3/1096 16/18670 0.06374 0.1654 0.1122 MAPRE2/MAPRE3/MID2 3 BP GO:0044065 regulation of respiratory system process 3/1096 16/18670 0.06374 0.1654 0.1122 FTO/MECP2/ADORA1 3 BP GO:0044794 positive regulation by host of viral process 3/1096 16/18670 0.06374 0.1654 0.1122 PC/APOE/VAPA 3 BP GO:0045986 negative regulation of smooth muscle contraction 3/1096 16/18670 0.06374 0.1654 0.1122 ADORA1/RGS2/PRKG1 3 BP GO:0050711 negative regulation of interleukin-1 secretion 3/1096 16/18670 0.06374 0.1654 0.1122 TNFAIP3/GAS6/NLRP3 3 BP GO:0055012 ventricular cardiac muscle cell differentiation 3/1096 16/18670 0.06374 0.1654 0.1122 MYH10/CCNB1/RXRA 3 BP GO:0060572 morphogenesis of an epithelial bud 3/1096 16/18670 0.06374 0.1654 0.1122 SULF1/AR/BMP4 3 BP GO:0071732 cellular response to nitric oxide 3/1096 16/18670 0.06374 0.1654 0.1122 FOXO1/CCNA2/AQP1 3 BP GO:0072224 metanephric glomerulus development 3/1096 16/18670 0.06374 0.1654 0.1122 ADIPOQ/LAMB2/PDGFRA 3 BP GO:0097067 cellular response to thyroid hormone stimulus 3/1096 16/18670 0.06374 0.1654 0.1122 SIX1/CTSL/CTSH 3 BP GO:0097091 synaptic vesicle clustering 3/1096 16/18670 0.06374 0.1654 0.1122 MAGI2/PCDH17/CDH2 3 BP GO:1900451 positive regulation of glutamate receptor signaling pathway 3/1096 16/18670 0.06374 0.1654 0.1122 CCR2/PINK1/CCL2 3 BP GO:1902992 negative regulation of amyloid precursor protein catabolic process 3/1096 16/18670 0.06374 0.1654 0.1122 BIN1/PIN1/APOE 3 BP GO:1990000 amyloid fibril formation 3/1096 16/18670 0.06374 0.1654 0.1122 CRYAB/GSN/APOE 3 BP GO:2001170 negative regulation of ATP biosynthetic process 3/1096 16/18670 0.06374 0.1654 0.1122 NUPR1/HDAC4/DDIT4 3 BP GO:0006475 internal protein amino acid acetylation 15/1096 166/18670 0.06401 0.166 0.1126 MECP2/KAT6B/PCK1/GATA3/PCGF2/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/JADE2 15 BP GO:0090276 regulation of peptide hormone secretion 18/1096 208/18670 0.06431 0.1667 0.1131 CCL5/ARL2/EGFR/TCF7L2/IL1B/RBP4/CD38/ICA1/HADH/OXCT1/HIF1A/EFNA5/LRP5/BAD/SLC25A4/SFRP1/INHBB/NNAT 18 BP GO:0098693 regulation of synaptic vesicle cycle 11/1096 112/18670 0.06453 0.1672 0.1134 MAGI2/STXBP1/PRKCB/DNM1/UNC13B/PCDH17/RIMS3/CDH2/PFN2/PPP3CC/ADCY1 11 BP GO:0007260 tyrosine phosphorylation of STAT protein 9/1096 86/18670 0.06488 0.1681 0.114 CCL5/CD40/HCLS1/INPP5F/PECAM1/PTPN2/FGFR3/CRLF1/IL15 9 BP GO:0002287 alpha-beta T cell activation involved in immune response 7/1096 61/18670 0.06542 0.1692 0.1148 IL4R/RELB/GATA3/GPR183/BATF/CD86/NLRP3 7 BP GO:0002293 alpha-beta T cell differentiation involved in immune response 7/1096 61/18670 0.06542 0.1692 0.1148 IL4R/RELB/GATA3/GPR183/BATF/CD86/NLRP3 7 BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 7/1096 61/18670 0.06542 0.1692 0.1148 RUNX3/IL4R/GATA3/CD83/NCKAP1L/CD86/NLRP3 7 BP GO:0007050 cell cycle arrest 20/1096 237/18670 0.06571 0.1698 0.1151 MAGI2/TGFB2/IRF1/BIN1/TCF7L2/SMAD3/BTG2/CXCL8/CCND1/CNOT1/CDKN2C/GAS6/PLK2/GAS1/CDK4/CCNB1/CNOT4/CARM1/TFAP4/PPM1A 20 BP GO:0003254 regulation of membrane depolarization 6/1096 49/18670 0.06577 0.1698 0.1151 ANK3/NEDD4L/CAV3/GOT1/MLLT11/FHL1 6 BP GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 6/1096 49/18670 0.06577 0.1698 0.1151 TNFAIP3/RHOH/ADIPOQ/HDAC1/STAT1/PPM1A 6 BP GO:1903018 regulation of glycoprotein metabolic process 6/1096 49/18670 0.06577 0.1698 0.1151 PLCB1/HBEGF/TCF7L2/CCR7/APCS/IL15 6 BP GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 6/1096 49/18670 0.06577 0.1698 0.1151 TNFSF10/PTPRC/PAK2/G0S2/TIMP3/SFRP1 6 BP GO:0046486 glycerolipid metabolic process 32/1096 414/18670 0.0683 0.1762 0.1195 PLCB1/LPL/MECP2/FABP4/PCK1/PTPN13/PIP4K2B/CPNE1/PLEK/SIK1/PNPLA6/GK/RGN/LIPC/PLSCR1/PLCG2/PNPLA4/SH3YL1/APOC1/GPAA1/INPP5F/ALDH5A1/PGAP2/CAV3/GPX1/PLA2G7/APOE/ARF3/INPP5D/AGPAT1/PLA2G15/PCK2 32 BP GO:0072331 signal transduction by p53 class mediator 22/1096 267/18670 0.06849 0.1766 0.1198 NDRG1/ATRX/NUPR1/BTG2/BATF/CNOT1/CD44/PDK2/PLK2/PIN1/DYRK2/CCNB1/HDAC1/EHMT2/KAT5/DDIT4/TWIST1/TPX2/CNOT4/CARM1/TFAP4/PTTG1IP 22 BP GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 10/1096 100/18670 0.06869 0.177 0.1201 RAC2/DZIP1/FNBP1L/AUTS2/CCR7/RALA/NCKAP1/HDAC4/COBL/TENM1 10 BP GO:1990845 adaptive thermogenesis 14/1096 154/18670 0.06898 0.1777 0.1205 NOVA1/IL4R/CXCR4/FABP4/VEGFA/ADIPOQ/THRA/ADIPOR2/HADH/ID1/UCP2/CCR2/G0S2/IL15 14 BP GO:1990778 protein localization to cell periphery 25/1096 311/18670 0.06924 0.1783 0.1209 TSPAN5/STXBP1/EPHA3/EGFR/ADIPOQ/ANK3/CLSTN1/EMP2/EPB41L2/DAG1/GPSM2/SPTBN1/RAB29/AR/GAS6/SKAP1/CAV3/MAPK10/GBP1/KCNB2/PRKCH/CSK/CDH2/PLK1/LYPLA1 25 BP GO:0010821 regulation of mitochondrion organization 16/1096 182/18670 0.06961 0.1786 0.1212 RAC2/HUWE1/GZMB/HK2/NOL3/TNFSF10/HIF1A/PINK1/GPX1/PLAUR/ZNF205/BAD/MLLT11/CTTN/BNIP3/PPP3CC 16 BP GO:0002707 negative regulation of lymphocyte mediated immunity 5/1096 38/18670 0.06969 0.1786 0.1212 IL7R/FCGR2B/PTPN6/PTPRC/PARP3 5 BP GO:0007340 acrosome reaction 5/1096 38/18670 0.06969 0.1786 0.1212 PLCB1/STXBP1/UNC13B/GLRB/TNP2 5 BP GO:0032350 regulation of hormone metabolic process 5/1096 38/18670 0.06969 0.1786 0.1212 GATA3/TCF7L2/IL1B/NFKB1/HIF1A 5 BP GO:0032620 interleukin-17 production 5/1096 38/18670 0.06969 0.1786 0.1212 RFTN1/IL27RA/MYD88/NCKAP1L/IL15 5 BP GO:0048009 insulin-like growth factor receptor signaling pathway 5/1096 38/18670 0.06969 0.1786 0.1212 PLCB1/AR/IGFBP6/IGFBP2/IGFBP5 5 BP GO:0060045 positive regulation of cardiac muscle cell proliferation 5/1096 38/18670 0.06969 0.1786 0.1212 TGFBR3/FGFR1/PIM1/CCNB1/BMPR1A 5 BP GO:0071604 transforming growth factor beta production 5/1096 38/18670 0.06969 0.1786 0.1212 TGFB2/ITGAV/CD200/SMAD3/HIF1A 5 BP GO:0086005 ventricular cardiac muscle cell action potential 5/1096 38/18670 0.06969 0.1786 0.1212 BIN1/NEDD4L/KCNJ8/CAV3/SNTA1 5 BP GO:1905898 positive regulation of response to endoplasmic reticulum stress 5/1096 38/18670 0.06969 0.1786 0.1212 FCGR2B/XBP1/ATF6/PTPN2/HERPUD1 5 BP GO:0099024 plasma membrane invagination 12/1096 127/18670 0.06986 0.179 0.1214 TRBC1/ARHGAP12/GULP1/GSN/FCGR2B/DOCK1/GATA2/IGKC/NCKAP1L/RHOBTB1/IGLC1/ITGB2 12 BP GO:0046824 positive regulation of nucleocytoplasmic transport 7/1096 62/18670 0.0702 0.1796 0.1218 TCF7L2/IL1B/SMAD3/ZIC1/HCLS1/GAS6/PPM1A 7 BP GO:0055025 positive regulation of cardiac muscle tissue development 7/1096 62/18670 0.0702 0.1796 0.1218 TGFBR3/FGFR1/PIN1/BMP4/PIM1/CCNB1/BMPR1A 7 BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 7/1096 62/18670 0.0702 0.1796 0.1218 TNFRSF10B/XBP1/CASP4/ATP2A1/PTPN2/WFS1/HERPUD1 7 BP GO:0009199 ribonucleoside triphosphate metabolic process 27/1096 341/18670 0.07047 0.1802 0.1222 ZBTB20/MECP2/ENPP1/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NME3/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1 27 BP GO:0000188 inactivation of MAPK activity 4/1096 27/18670 0.07072 0.1802 0.1222 DUSP5/DUSP14/DUSP2/DUSP3 4 BP GO:0002026 regulation of the force of heart contraction 4/1096 27/18670 0.07072 0.1802 0.1222 PLN/MYL2/MYH7/MYL3 4 BP GO:0002825 regulation of T-helper 1 type immune response 4/1096 27/18670 0.07072 0.1802 0.1222 IL4R/IL1B/IL27RA/CCR2 4 BP GO:0032673 regulation of interleukin-4 production 4/1096 27/18670 0.07072 0.1802 0.1222 GATA3/CD83/CD86/NLRP3 4 BP GO:0043921 modulation by host of viral transcription 4/1096 27/18670 0.07072 0.1802 0.1222 CCL5/HDAC1/TFAP4/JUN 4 BP GO:0048668 collateral sprouting 4/1096 27/18670 0.07072 0.1802 0.1222 SPP1/EFNA5/NGF/COBL 4 BP GO:0052472 modulation by host of symbiont transcription 4/1096 27/18670 0.07072 0.1802 0.1222 CCL5/HDAC1/TFAP4/JUN 4 BP GO:0072207 metanephric epithelium development 4/1096 27/18670 0.07072 0.1802 0.1222 WWTR1/ADIPOQ/STAT1/LAMB2 4 BP GO:0001706 endoderm formation 6/1096 50/18670 0.07121 0.1811 0.1228 ITGAV/ITGA4/PAF1/ITGA5/ITGB2/MMP15 6 BP GO:0002931 response to ischemia 6/1096 50/18670 0.07121 0.1811 0.1228 EEF2/HK2/NOL3/CX3CR1/PINK1/UCHL1 6 BP GO:0072698 protein localization to microtubule cytoskeleton 6/1096 50/18670 0.07121 0.1811 0.1228 MAPRE2/MAPRE3/MID2/SPAG5/DCTN2/STIL 6 BP GO:0086009 membrane repolarization 6/1096 50/18670 0.07121 0.1811 0.1228 NEDD4L/KCNJ8/CASQ2/CAV3/AKAP9/SNTA1 6 BP GO:2000725 regulation of cardiac muscle cell differentiation 6/1096 50/18670 0.07121 0.1811 0.1228 PAK1/RGS2/CAV3/PIN1/BMP4/FZD7 6 BP GO:0005976 polysaccharide metabolic process 11/1096 114/18670 0.07136 0.1813 0.123 PPP1R3C/ENPP1/PYGM/NFKB1/PYGB/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2/AOAH 11 BP GO:0015749 monosaccharide transmembrane transport 11/1096 114/18670 0.07136 0.1813 0.123 ADIPOQ/SLC2A3/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/SLC5A3/SLC23A2/INSR/SLC2A5 11 BP GO:1902652 secondary alcohol metabolic process 14/1096 155/18670 0.07194 0.1827 0.1239 CH25H/CYB5R3/HDLBP/LIPC/NPC1/ABCG1/FGFR1/APOC1/NFE2L1/LBR/PMVK/APOE/APOF/RXRA 14 BP GO:0009156 ribonucleoside monophosphate biosynthetic process 17/1096 197/18670 0.0721 0.1829 0.1241 ZBTB20/ADA/NUPR1/PFKM/HK2/AMPD3/INSR/HPRT1/HIF1A/PINK1/AK1/HDAC4/DDIT4/IMPDH1/NUP210/IMPDH2/ALDOA 17 BP GO:0009749 response to glucose 17/1096 197/18670 0.0721 0.1829 0.1241 ZBTB20/LPL/ADIPOQ/PCK1/ICAM1/PTK2B/TCF7L2/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/BAD/ANGPT2/PCK2 17 BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 8/1096 75/18670 0.07227 0.1833 0.1243 CCL5/ADIPOQ/PXDN/IL1RN/NOL3/PTPRC/GAS6/PTPN2 8 BP GO:0002027 regulation of heart rate 10/1096 101/18670 0.07243 0.1835 0.1244 SEMA3A/ADA/BIN1/PLN/GCH1/CASQ2/MYH7/CAV3/AKAP9/SNTA1 10 BP GO:0046545 development of primary female sexual characteristics 10/1096 101/18670 0.07243 0.1835 0.1244 VEGFA/ICAM1/NUPR1/HSPA5/INSR/LFNG/FOXC1/SFRP1/PDGFRA/INHBB 10 BP GO:1904062 regulation of cation transmembrane transport 27/1096 342/18670 0.07244 0.1835 0.1244 CORO1A/P2RY6/ANK3/BIN1/PTK2B/SHANK2/FXYD1/NEDD4L/PLN/PTPN6/RGN/RGS2/CASQ2/KCNAB1/PLCG2/CCR2/CAV3/AKAP9/F2R/THY1/PINK1/ATP2A1/SNTA1/CXCL10/TWIST1/CCL2/FHL1 27 BP GO:0043506 regulation of JUN kinase activity 9/1096 88/18670 0.07284 0.1842 0.125 PTK2B/PAK1/DAXX/MAP3K4/SASH1/PTPN22/MAP4K1/ARHGEF5/SFRP1 9 BP GO:0045921 positive regulation of exocytosis 9/1096 88/18670 0.07284 0.1842 0.125 IL4R/STXBP1/SDC1/GAB2/RAB27A/PTAFR/GATA2/UNC13B/ITGB2 9 BP GO:0106027 neuron projection organization 9/1096 88/18670 0.07284 0.1842 0.125 SIPA1L1/ZNF365/FCGR2B/SHANK2/INSR/APOE/CTTN/PDLIM5/LGMN 9 BP GO:0034763 negative regulation of transmembrane transport 12/1096 128/18670 0.07319 0.1849 0.1254 ANK3/ENPP1/PRKCB/BIN1/IL1B/NEDD4L/PLN/RGS2/CASQ2/KCNAB1/CAV3/TWIST1 12 BP GO:0051291 protein heterooligomerization 12/1096 128/18670 0.07319 0.1849 0.1254 MAGI2/HBB/GCHFR/ADIPOQ/BIRC3/GCH1/INSR/COL1A1/PCBD1/IKZF1/GLRB/HBE1 12 BP GO:0031647 regulation of protein stability 23/1096 284/18670 0.07394 0.1859 0.1261 CRYAB/STXBP1/GSN/SMAD3/XBP1/NEDD4L/PEX19/ASPH/ID1/CTSH/PIN1/PINK1/CRTAP/PIM1/PHB/HIP1/CAMLG/USP7/TADA3/PIM2/PLK1/PFN2/WFS1 23 BP GO:0003184 pulmonary valve morphogenesis 3/1096 17/18670 0.07414 0.1859 0.1261 TGFB2/BMP4/SMAD6 3 BP GO:0006883 cellular sodium ion homeostasis 3/1096 17/18670 0.07414 0.1859 0.1261 NEDD4L/ATP4B/C7 3 BP GO:0017085 response to insecticide 3/1096 17/18670 0.07414 0.1859 0.1261 DAXX/CCNB1/MAPK13 3 BP GO:0030011 maintenance of cell polarity 3/1096 17/18670 0.07414 0.1859 0.1261 DST/DLG5/NCKAP1L 3 BP GO:0030540 female genitalia development 3/1096 17/18670 0.07414 0.1859 0.1261 AXL/RBP4/TYRO3 3 BP GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 3/1096 17/18670 0.07414 0.1859 0.1261 PAK1/AR/LMO3 3 BP GO:0035988 chondrocyte proliferation 3/1096 17/18670 0.07414 0.1859 0.1261 DDR2/STC1/FGFR3 3 BP GO:0043649 dicarboxylic acid catabolic process 3/1096 17/18670 0.07414 0.1859 0.1261 GOT2/ASPA/GOT1 3 BP GO:0045187 regulation of circadian sleep/wake cycle, sleep 3/1096 17/18670 0.07414 0.1859 0.1261 ADA/ADORA1/PTGDS 3 BP GO:0048535 lymph node development 3/1096 17/18670 0.07414 0.1859 0.1261 IL7R/PDPN/IL15 3 BP GO:0050884 neuromuscular process controlling posture 3/1096 17/18670 0.07414 0.1859 0.1261 MECP2/GCH1/TCF15 3 BP GO:0060263 regulation of respiratory burst 3/1096 17/18670 0.07414 0.1859 0.1261 RAC2/INSR/LBP 3 BP GO:0061323 cell proliferation involved in heart morphogenesis 3/1096 17/18670 0.07414 0.1859 0.1261 SIX1/BMP4/PIM1 3 BP GO:0072673 lamellipodium morphogenesis 3/1096 17/18670 0.07414 0.1859 0.1261 CD44/PDPN/KANK1 3 BP GO:1902931 negative regulation of alcohol biosynthetic process 3/1096 17/18670 0.07414 0.1859 0.1261 PLEK/NFKB1/APOE 3 BP GO:1903975 regulation of glial cell migration 3/1096 17/18670 0.07414 0.1859 0.1261 GPR183/CX3CR1/CCR2 3 BP GO:2000136 regulation of cell proliferation involved in heart morphogenesis 3/1096 17/18670 0.07414 0.1859 0.1261 SIX1/BMP4/PIM1 3 BP GO:0072376 protein activation cascade 17/1096 198/18670 0.07478 0.1874 0.1271 TRBC1/FCN1/CFB/IL1B/CFP/CFD/TFPI/IGKC/CFI/PHB/F8/IGLV6-57/C6/APCS/IGLC1/C7/C3AR1 17 BP GO:0030449 regulation of complement activation 11/1096 115/18670 0.07495 0.1877 0.1273 CFB/IL1B/CFP/IGKC/CFI/PHB/IGLV6-57/C6/IGLC1/C7/C3AR1 11 BP GO:0016573 histone acetylation 14/1096 156/18670 0.07498 0.1877 0.1273 MECP2/KAT6B/GATA3/PCGF2/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/JADE2 14 BP GO:0034767 positive regulation of ion transmembrane transport 14/1096 156/18670 0.07498 0.1877 0.1273 P2RY6/ANK3/FXYD1/RGN/PTAFR/PLCG2/CCR2/AKAP9/F2R/THY1/PINK1/ATP2A1/CXCL10/CCL2 14 BP GO:0031571 mitotic G1 DNA damage checkpoint 7/1096 63/18670 0.07518 0.1878 0.1274 BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1 7 BP GO:0044819 mitotic G1/S transition checkpoint 7/1096 63/18670 0.07518 0.1878 0.1274 BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1 7 BP GO:0046622 positive regulation of organ growth 7/1096 63/18670 0.07518 0.1878 0.1274 TGFBR3/FGFR1/PIN1/PIM1/CCNB1/BASP1/BMPR1A 7 BP GO:0071772 response to BMP 15/1096 170/18670 0.07522 0.1878 0.1274 TGFBR3/GATA3/SULF1/MAPK3/SFRP4/CDH5/SMAD1/ID1/BMP4/HTRA1/BMPR1A/SFRP1/PPM1A/SPINT2/SMAD6 15 BP GO:0071773 cellular response to BMP stimulus 15/1096 170/18670 0.07522 0.1878 0.1274 TGFBR3/GATA3/SULF1/MAPK3/SFRP4/CDH5/SMAD1/ID1/BMP4/HTRA1/BMPR1A/SFRP1/PPM1A/SPINT2/SMAD6 15 BP GO:0009072 aromatic amino acid family metabolic process 5/1096 39/18670 0.07626 0.1897 0.1287 FAH/HPD/HDC/PCBD1/QDPR 5 BP GO:0030501 positive regulation of bone mineralization 5/1096 39/18670 0.07626 0.1897 0.1287 SMAD3/NELL1/BMP4/BMPR1A/OSR2 5 BP GO:0033574 response to testosterone 5/1096 39/18670 0.07626 0.1897 0.1287 SPP1/PLN/AR/CDK4/BAD 5 BP GO:0045684 positive regulation of epidermis development 5/1096 39/18670 0.07626 0.1897 0.1287 TGFB2/SFRP4/BMP4/PRKCH/FOXC1 5 BP GO:0055090 acylglycerol homeostasis 5/1096 39/18670 0.07626 0.1897 0.1287 LPL/XBP1/ADORA1/LIPC/APOE 5 BP GO:0060306 regulation of membrane repolarization 5/1096 39/18670 0.07626 0.1897 0.1287 NEDD4L/CASQ2/CAV3/AKAP9/SNTA1 5 BP GO:0070328 triglyceride homeostasis 5/1096 39/18670 0.07626 0.1897 0.1287 LPL/XBP1/ADORA1/LIPC/APOE 5 BP GO:1902116 negative regulation of organelle assembly 5/1096 39/18670 0.07626 0.1897 0.1287 CDK10/NUPR1/CAV3/PINK1/MAP4 5 BP GO:2000648 positive regulation of stem cell proliferation 5/1096 39/18670 0.07626 0.1897 0.1287 VEGFA/PTPRC/CX3CR1/SMARCD3/HIF1A 5 BP GO:0021549 cerebellum development 10/1096 102/18670 0.0763 0.1897 0.1287 SERPINE2/MECP2/ZNF365/FCGR2B/PAK1/MYH10/HSPA5/B4GALT2/RERE/FOXC1 10 BP GO:0090596 sensory organ morphogenesis 21/1096 256/18670 0.07643 0.1899 0.1288 VEGFA/CDON/SIX1/GATA3/ZIC1/RBP4/MAPK3/FZD2/FGFR1/GATA2/HIF1A/THY1/BMP4/DIO3/HDAC1/LRP5/EFEMP1/TWIST1/ABR/OSR2/RING1 21 BP GO:0042310 vasoconstriction 8/1096 76/18670 0.07684 0.1908 0.1294 EGFR/ICAM1/PTAFR/CD38/ACTA2/F2R/AGTR1/CHRM3 8 BP GO:0072088 nephron epithelium morphogenesis 8/1096 76/18670 0.07684 0.1908 0.1294 VEGFA/SIX1/GATA3/MAGED1/BMP4/STAT1/CTNNBIP1/HOXA11 8 BP GO:0030834 regulation of actin filament depolymerization 6/1096 51/18670 0.0769 0.1908 0.1294 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/CAPG 6 BP GO:0051496 positive regulation of stress fiber assembly 6/1096 51/18670 0.0769 0.1908 0.1294 ARHGEF10/SMAD3/PAK1/ARHGEF5/SFRP1/PFN2 6 BP GO:0046390 ribose phosphate biosynthetic process 24/1096 300/18670 0.07699 0.1909 0.1295 ZBTB20/NUPR1/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/PAPSS2/AK1/HDAC4/DDIT4/NME3/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/ADCY1 24 BP GO:1902275 regulation of chromatin organization 16/1096 185/18670 0.07799 0.1933 0.1311 MECP2/VEGFA/HMGA1/GATA3/ATRX/IL1B/AUTS2/MAPK3/GATA2/PAF1/PINK1/CCNB1/ZNHIT1/TADA3/JARID2/TWIST1 16 BP GO:1905952 regulation of lipid localization 14/1096 157/18670 0.07811 0.1935 0.1313 SPP1/LPL/FTO/ITGAV/ADIPOQ/IL1B/NFKBIA/NFKB1/ABCG1/APOC1/APOE/AGTR1/PTPN2/IKBKE 14 BP GO:0060828 regulation of canonical Wnt signaling pathway 23/1096 286/18670 0.07848 0.1936 0.1313 FOXO1/SEMA5A/WWTR1/CDK14/EGFR/TCF7L2/SMAD3/SFRP4/NFKB1/COL1A1/KANK1/IGFBP6/PIN1/RAPGEF1/IGFBP2/FZD7/HDAC1/GPC5/APOE/G3BP1/CDH2/SFRP1/PPM1A 23 BP GO:0034219 carbohydrate transmembrane transport 11/1096 116/18670 0.07864 0.1936 0.1313 ADIPOQ/SLC2A3/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/SLC5A3/SLC23A2/INSR/SLC2A5 11 BP GO:1900180 regulation of protein localization to nucleus 11/1096 116/18670 0.07864 0.1936 0.1313 ANGPT1/DCLK1/SMAD3/ZIC1/LILRB4/MFHAS1/PKIG/HCLS1/PIN1/BMP4/PLK1 11 BP GO:2000257 regulation of protein activation cascade 11/1096 116/18670 0.07864 0.1936 0.1313 CFB/IL1B/CFP/IGKC/CFI/PHB/IGLV6-57/C6/IGLC1/C7/C3AR1 11 BP GO:0001516 prostaglandin biosynthetic process 4/1096 28/18670 0.07885 0.1936 0.1313 PTGS1/HPGDS/IL1B/PTGDS 4 BP GO:0001702 gastrulation with mouth forming second 4/1096 28/18670 0.07885 0.1936 0.1313 ETS2/LRP5/UGDH/AMOT 4 BP GO:0001773 myeloid dendritic cell activation 4/1096 28/18670 0.07885 0.1936 0.1313 RELB/SLAMF1/CD2/BATF 4 BP GO:0003180 aortic valve morphogenesis 4/1096 28/18670 0.07885 0.1936 0.1313 GATA3/BMP4/TWIST1/SMAD6 4 BP GO:0006972 hyperosmotic response 4/1096 28/18670 0.07885 0.1936 0.1313 AKR1B1/EFHD1/AQP1/MAPK10 4 BP GO:0008045 motor neuron axon guidance 4/1096 28/18670 0.07885 0.1936 0.1313 RAC2/EGR2/SEMA3A/CHN1 4 BP GO:0031440 regulation of mRNA 3'-end processing 4/1096 28/18670 0.07885 0.1936 0.1313 SNRPA/PAF1/CCNB1/SUPT5H 4 BP GO:0033598 mammary gland epithelial cell proliferation 4/1096 28/18670 0.07885 0.1936 0.1313 GATA3/CCND1/HOXA5/GPX1 4 BP GO:0033688 regulation of osteoblast proliferation 4/1096 28/18670 0.07885 0.1936 0.1313 ITGAV/SMAD3/NELL1/SFRP1 4 BP GO:0034698 response to gonadotropin 4/1096 28/18670 0.07885 0.1936 0.1313 TGFBR3/ICAM1/CCNA2/EFNA5 4 BP GO:0046457 prostanoid biosynthetic process 4/1096 28/18670 0.07885 0.1936 0.1313 PTGS1/HPGDS/IL1B/PTGDS 4 BP GO:0048679 regulation of axon regeneration 4/1096 28/18670 0.07885 0.1936 0.1313 SPP1/NTRK3/INPP5F/PTPRF 4 BP GO:0051647 nucleus localization 4/1096 28/18670 0.07885 0.1936 0.1313 BIN1/MYH10/CAV3/TRIM58 4 BP GO:0090344 negative regulation of cell aging 4/1096 28/18670 0.07885 0.1936 0.1313 AKT3/NAMPT/PLK2/TWIST1 4 BP GO:1902003 regulation of amyloid-beta formation 4/1096 28/18670 0.07885 0.1936 0.1313 BIN1/ABCG1/PIN1/APOE 4 BP GO:1902745 positive regulation of lamellipodium organization 4/1096 28/18670 0.07885 0.1936 0.1313 RAC2/AUTS2/NCKAP1/HDAC4 4 BP GO:1902932 positive regulation of alcohol biosynthetic process 4/1096 28/18670 0.07885 0.1936 0.1313 P2RY6/IL1B/PTAFR/ABCG1 4 BP GO:0009266 response to temperature stimulus 20/1096 243/18670 0.08011 0.1966 0.1333 FOXO1/CXCR4/LPL/CRYAB/THRA/CIRBP/IGFBP7/DAXX/MAPK3/ADORA1/BAG1/NFKBIA/HSPA5/CD14/UCP2/NFE2L1/PSIP1/CXCL10/CXCL12/NUP210 20 BP GO:0035601 protein deacylation 10/1096 103/18670 0.0803 0.1967 0.1334 VEGFA/NACC2/PINK1/HDAC1/ZNHIT1/PHB/TADA3/MSL3/HDAC4/LYPLA1 10 BP GO:0044264 cellular polysaccharide metabolic process 10/1096 103/18670 0.0803 0.1967 0.1334 PPP1R3C/ENPP1/PYGM/PYGB/INSR/DYRK2/PPP1R2/PPP1R1A/PHLDA2/AOAH 10 BP GO:1905269 positive regulation of chromatin organization 10/1096 103/18670 0.0803 0.1967 0.1334 MECP2/VEGFA/GATA3/IL1B/AUTS2/MAPK3/PAF1/PINK1/CCNB1/JARID2 10 BP GO:0036498 IRE1-mediated unfolded protein response 7/1096 64/18670 0.08036 0.1967 0.1334 XBP1/HSPA5/GFPT1/KDELR3/WFS1/TSPYL2/ATP6V0D1 7 BP GO:0044783 G1 DNA damage checkpoint 7/1096 64/18670 0.08036 0.1967 0.1334 BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1 7 BP GO:1903672 positive regulation of sprouting angiogenesis 7/1096 64/18670 0.08036 0.1967 0.1334 VEGFA/AKT3/SMAD1/PLK2/GATA2/ITGA5/AGTR1 7 BP GO:1904064 positive regulation of cation transmembrane transport 13/1096 144/18670 0.08098 0.1981 0.1344 P2RY6/ANK3/FXYD1/RGN/PLCG2/CCR2/AKAP9/F2R/THY1/PINK1/ATP2A1/CXCL10/CCL2 13 BP GO:0042475 odontogenesis of dentin-containing tooth 9/1096 90/18670 0.08138 0.199 0.135 FOXO1/NFIC/BMP4/HDAC1/HTRA1/SERPINE1/BMPR1A/FOXC1/PDGFRA 9 BP GO:0048678 response to axon injury 8/1096 77/18670 0.08157 0.1994 0.1352 SPP1/NTRK3/DAG1/INPP5F/PTPRF/LAMB2/JUN/GAP43 8 BP GO:0031398 positive regulation of protein ubiquitination 11/1096 117/18670 0.08244 0.2015 0.1366 HUWE1/ANGPT1/BIRC3/HSPA5/PTPN22/PIN1/PINK1/NMI/PLK1/WFS1/PTTG1IP 11 BP GO:0032731 positive regulation of interleukin-1 beta production 6/1096 52/18670 0.08284 0.2022 0.1371 LPL/AIM2/SMAD3/HSPB1/LILRA2/NLRP3 6 BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 6/1096 52/18670 0.08284 0.2022 0.1371 POSTN/DOCK1/PDPN/KANK1/EFNA5/GBP1 6 BP GO:2000772 regulation of cellular senescence 6/1096 52/18670 0.08284 0.2022 0.1371 HMGA1/AKT3/NAMPT/PLK2/BMPR1A/TWIST1 6 BP GO:0009141 nucleoside triphosphate metabolic process 28/1096 362/18670 0.08307 0.2023 0.1372 ZBTB20/MECP2/ENPP1/ADA/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NME3/NDUFB7/NDUFV1/GUK1/IMPDH1/NUP210/IMPDH2/ALDOA/UQCRC1 28 BP GO:0009268 response to pH 5/1096 40/18670 0.08315 0.2023 0.1372 PCK1/PAM/GNA11/LGMN/HYAL1 5 BP GO:0045823 positive regulation of heart contraction 5/1096 40/18670 0.08315 0.2023 0.1372 TGFB2/ADA/GCH1/RGS2/ATP2A1 5 BP GO:0046621 negative regulation of organ growth 5/1096 40/18670 0.08315 0.2023 0.1372 PAK1/RBP4/RGS2/CAV3/JARID2 5 BP GO:0050832 defense response to fungus 5/1096 40/18670 0.08315 0.2023 0.1372 RARRES2/S100A9/IL17RA/GNLY/ELANE 5 BP GO:0072210 metanephric nephron development 5/1096 40/18670 0.08315 0.2023 0.1372 ADIPOQ/BMP4/STAT1/LAMB2/PDGFRA 5 BP GO:0072583 clathrin-dependent endocytosis 5/1096 40/18670 0.08315 0.2023 0.1372 FNBP1L/ITGA4/INPP5F/HIP1/SNAP91 5 BP GO:0046887 positive regulation of hormone secretion 12/1096 131/18670 0.08375 0.2036 0.1381 SPP1/EGFR/TCF7L2/RBP4/NMB/CD38/OXCT1/FGFR1/HIF1A/BAD/INHBB/NNAT 12 BP GO:1902807 negative regulation of cell cycle G1/S phase transition 12/1096 131/18670 0.08375 0.2036 0.1381 BTG2/CCND1/CNOT1/CDKN2C/NACC2/PLK2/CDK4/CCNB1/CNOT4/CARM1/CCL2/FHL1 12 BP GO:0019233 sensory perception of pain 10/1096 104/18670 0.08442 0.205 0.139 CXCR4/MECP2/MAPK3/ADORA1/PTAFR/CCR2/F2R/UCHL1/CXCL12/CCL2 10 BP GO:0032414 positive regulation of ion transmembrane transporter activity 10/1096 104/18670 0.08442 0.205 0.139 P2RY6/ANK3/RGN/PTAFR/PLCG2/CCR2/AKAP9/PINK1/ATP2A1/CCL2 10 BP GO:0098732 macromolecule deacylation 10/1096 104/18670 0.08442 0.205 0.139 VEGFA/NACC2/PINK1/HDAC1/ZNHIT1/PHB/TADA3/MSL3/HDAC4/LYPLA1 10 BP GO:0001911 negative regulation of leukocyte mediated cytotoxicity 3/1096 18/18670 0.08524 0.2058 0.1396 IL7R/FCGR2B/PTPRC 3 BP GO:0010832 negative regulation of myotube differentiation 3/1096 18/18670 0.08524 0.2058 0.1396 XBP1/CXCL10/HDAC4 3 BP GO:0030809 negative regulation of nucleotide biosynthetic process 3/1096 18/18670 0.08524 0.2058 0.1396 NUPR1/HDAC4/DDIT4 3 BP GO:0034199 activation of protein kinase A activity 3/1096 18/18670 0.08524 0.2058 0.1396 ADCY9/ADCY6/ADCY1 3 BP GO:0044320 cellular response to leptin stimulus 3/1096 18/18670 0.08524 0.2058 0.1396 UGCG/CCNA2/INHBB 3 BP GO:0070633 transepithelial transport 3/1096 18/18670 0.08524 0.2058 0.1396 P2RY6/SLC23A2/AQP1 3 BP GO:0071605 monocyte chemotactic protein-1 production 3/1096 18/18670 0.08524 0.2058 0.1396 ADIPOQ/IL1B/TWIST1 3 BP GO:0071637 regulation of monocyte chemotactic protein-1 production 3/1096 18/18670 0.08524 0.2058 0.1396 ADIPOQ/IL1B/TWIST1 3 BP GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 3/1096 18/18670 0.08524 0.2058 0.1396 VEGFA/SIX1/MAGED1 3 BP GO:0090196 regulation of chemokine secretion 3/1096 18/18670 0.08524 0.2058 0.1396 IL4R/LPL/POSTN 3 BP GO:0090330 regulation of platelet aggregation 3/1096 18/18670 0.08524 0.2058 0.1396 SERPINE2/PDPN/PRKG1 3 BP GO:0150078 positive regulation of neuroinflammatory response 3/1096 18/18670 0.08524 0.2058 0.1396 NUPR1/IL1B/CTSC 3 BP GO:1900372 negative regulation of purine nucleotide biosynthetic process 3/1096 18/18670 0.08524 0.2058 0.1396 NUPR1/HDAC4/DDIT4 3 BP GO:0060675 ureteric bud morphogenesis 7/1096 65/18670 0.08574 0.2068 0.1403 VEGFA/SIX1/GATA3/MAGED1/BMP4/CTNNBIP1/HOXA11 7 BP GO:1901016 regulation of potassium ion transmembrane transporter activity 7/1096 65/18670 0.08574 0.2068 0.1403 ANK3/NEDD4L/CASQ2/KCNAB1/CAV3/AKAP9/FHL1 7 BP GO:1904063 negative regulation of cation transmembrane transport 9/1096 91/18670 0.08587 0.2071 0.1404 ANK3/BIN1/NEDD4L/PLN/RGS2/CASQ2/KCNAB1/CAV3/TWIST1 9 BP GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 8/1096 78/18670 0.08647 0.2083 0.1413 PAK1/CNOT1/AR/HDAC1/PHB/LMO3/CARM1/SFRP1 8 BP GO:0061333 renal tubule morphogenesis 8/1096 78/18670 0.08647 0.2083 0.1413 VEGFA/SIX1/GATA3/MAGED1/BMP4/CTNNBIP1/HOXA11/COL4A1 8 BP GO:0072028 nephron morphogenesis 8/1096 78/18670 0.08647 0.2083 0.1413 VEGFA/SIX1/GATA3/MAGED1/BMP4/STAT1/CTNNBIP1/HOXA11 8 BP GO:0007628 adult walking behavior 4/1096 29/18670 0.08741 0.2095 0.1421 ZIC1/NPC1/UCHL1/GLRB 4 BP GO:0010575 positive regulation of vascular endothelial growth factor production 4/1096 29/18670 0.08741 0.2095 0.1421 IL1B/SULF1/HIF1A/C3AR1 4 BP GO:0021602 cranial nerve morphogenesis 4/1096 29/18670 0.08741 0.2095 0.1421 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0031063 regulation of histone deacetylation 4/1096 29/18670 0.08741 0.2095 0.1421 VEGFA/PINK1/ZNHIT1/TADA3 4 BP GO:0044068 modulation by symbiont of host cellular process 4/1096 29/18670 0.08741 0.2095 0.1421 ITGAV/NTRK3/BAD/VAPA 4 BP GO:0044788 modulation by host of viral process 4/1096 29/18670 0.08741 0.2095 0.1421 PC/APOE/APCS/VAPA 4 BP GO:0046134 pyrimidine nucleoside biosynthetic process 4/1096 29/18670 0.08741 0.2095 0.1421 DCK/NME3/TYMP/TK2 4 BP GO:0060142 regulation of syncytium formation by plasma membrane fusion 4/1096 29/18670 0.08741 0.2095 0.1421 IL4R/CD53/CXCL10/TNFSF14 4 BP GO:0070723 response to cholesterol 4/1096 29/18670 0.08741 0.2095 0.1421 DAG1/CCR5/NFE2L1/PMVK 4 BP GO:0071280 cellular response to copper ion 4/1096 29/18670 0.08741 0.2095 0.1421 DAXX/MT1G/NFE2L1/AQP1 4 BP GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 4/1096 29/18670 0.08741 0.2095 0.1421 CDK10/KANK1/MAP4/PFN2 4 BP GO:0030518 intracellular steroid hormone receptor signaling pathway 12/1096 132/18670 0.08748 0.2096 0.1422 PAK1/DAXX/CNOT1/TRIP4/AR/HDAC1/PHB/TADA3/LMO3/KAT5/CARM1/SFRP1 12 BP GO:0043266 regulation of potassium ion transport 10/1096 105/18670 0.08867 0.2123 0.144 ANK3/BIN1/PTK2B/ADORA1/NEDD4L/CASQ2/KCNAB1/CAV3/AKAP9/FHL1 10 BP GO:0046034 ATP metabolic process 24/1096 305/18670 0.08868 0.2123 0.144 ZBTB20/MECP2/ENPP1/NUPR1/PFKM/HK2/COX7A1/AMPD3/INSR/MYH7/HIF1A/PINK1/CCNB1/COX6A2/BAD/AK1/HDAC4/DDIT4/NDUFB7/NDUFV1/GUK1/NUP210/ALDOA/UQCRC1 24 BP GO:0032964 collagen biosynthetic process 6/1096 53/18670 0.08902 0.2129 0.1444 ADAMTS3/COL1A1/TRAM2/F2R/GOT1/BMP4 6 BP GO:0035065 regulation of histone acetylation 6/1096 53/18670 0.08902 0.2129 0.1444 GATA3/IL1B/AUTS2/MAPK3/GATA2/TWIST1 6 BP GO:0050702 interleukin-1 beta secretion 6/1096 53/18670 0.08902 0.2129 0.1444 TNFAIP3/LPL/AIM2/CCR7/LILRA2/NLRP3 6 BP GO:0035136 forelimb morphogenesis 5/1096 41/18670 0.09036 0.2156 0.1462 ZBTB16/ATRX/TWIST1/OSR2/HOXA11 5 BP GO:0050434 positive regulation of viral transcription 5/1096 41/18670 0.09036 0.2156 0.1462 POLR2E/POLR2I/TFAP4/JUN/SUPT5H 5 BP GO:0061028 establishment of endothelial barrier 5/1096 41/18670 0.09036 0.2156 0.1462 VEGFA/ICAM1/IL1B/CDH5/RAPGEF1 5 BP GO:0090224 regulation of spindle organization 5/1096 41/18670 0.09036 0.2156 0.1462 GPSM2/PARP3/SPAG5/TPX2/PLK1 5 BP GO:0097178 ruffle assembly 5/1096 41/18670 0.09036 0.2156 0.1462 ICAM1/SH3YL1/KANK1/COBL/PFN2 5 BP GO:0042866 pyruvate biosynthetic process 11/1096 119/18670 0.09039 0.2156 0.1462 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/SDS/NUP210/ALDOA 11 BP GO:0006956 complement activation 15/1096 175/18670 0.09095 0.2168 0.1471 TRBC1/FCN1/CFB/IL1B/CFP/CFD/IGKC/CFI/PHB/IGLV6-57/C6/APCS/IGLC1/C7/C3AR1 15 BP GO:0007224 smoothened signaling pathway 12/1096 133/18670 0.0913 0.2173 0.1474 SERPINE2/DZIP1/CDON/ENPP1/ZIC1/DLG5/DYRK2/BMP4/GAS1/B9D1/SFRP1/STIL 12 BP GO:0071333 cellular response to glucose stimulus 12/1096 133/18670 0.0913 0.2173 0.1474 ZBTB20/PCK1/ICAM1/XBP1/OXCT1/GAS6/HIF1A/EFNA5/UNC13B/LRP5/BAD/PCK2 12 BP GO:0046888 negative regulation of hormone secretion 7/1096 66/18670 0.09132 0.2173 0.1474 ADIPOQ/IL1B/ADORA1/NMB/HADH/SFRP1/INHBB 7 BP GO:0051926 negative regulation of calcium ion transport 7/1096 66/18670 0.09132 0.2173 0.1474 LILRB2/ICAM1/BIN1/STC1/PLN/CASQ2/CAV3 7 BP GO:0072171 mesonephric tubule morphogenesis 7/1096 66/18670 0.09132 0.2173 0.1474 VEGFA/SIX1/GATA3/MAGED1/BMP4/CTNNBIP1/HOXA11 7 BP GO:0018393 internal peptidyl-lysine acetylation 14/1096 161/18670 0.09146 0.2175 0.1475 MECP2/KAT6B/GATA3/PCGF2/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/JADE2 14 BP GO:0006473 protein acetylation 17/1096 204/18670 0.09224 0.2191 0.1486 FOXO1/MECP2/KAT6B/PCK1/GATA3/PCGF2/NUPR1/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/JADE2 17 BP GO:0031396 regulation of protein ubiquitination 17/1096 204/18670 0.09224 0.2191 0.1486 TNFAIP3/HUWE1/ANGPT1/BIRC3/DAXX/HSPA5/SASH1/PTPN22/PIN1/PINK1/NMI/CAMLG/PLK1/WFS1/HERPUD1/PTTG1IP/GLMN 17 BP GO:0034764 positive regulation of transmembrane transport 17/1096 204/18670 0.09224 0.2191 0.1486 P2RY6/ADIPOQ/ANK3/ADIPOR2/FXYD1/RGN/PTAFR/INSR/PLCG2/CCR2/AKAP9/F2R/THY1/PINK1/ATP2A1/CXCL10/CCL2 17 BP GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 11/1096 120/18670 0.09453 0.2244 0.1522 PTK2B/NUPR1/RGN/RNF144A/CTSC/TRIB2/PLK2/CAV3/PLK1/USP5/HERPUD1 11 BP GO:0006165 nucleoside diphosphate phosphorylation 12/1096 134/18670 0.09523 0.2258 0.1531 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/AK1/HDAC4/DDIT4/NME3/NUP210/ALDOA 12 BP GO:0006766 vitamin metabolic process 12/1096 134/18670 0.09523 0.2258 0.1531 SLC2A3/ENPP1/IL1B/RGN/SLC23A2/CYB5R3/NFKB1/PC/FGFR1/MTHFD2/LGMN/RXRA 12 BP GO:0006476 protein deacetylation 9/1096 93/18670 0.09527 0.2258 0.1531 VEGFA/NACC2/PINK1/HDAC1/ZNHIT1/PHB/TADA3/MSL3/HDAC4 9 BP GO:0072080 nephron tubule development 9/1096 93/18670 0.09527 0.2258 0.1531 WWTR1/VEGFA/SIX1/GATA3/MAGED1/BMP4/STAT1/CTNNBIP1/HOXA11 9 BP GO:0071453 cellular response to oxygen levels 19/1096 234/18670 0.09534 0.2258 0.1531 FOXO1/ADAM8/VEGFA/NDRG1/PCK1/ICAM1/STC1/NAMPT/NOL3/HIF1A/PINK1/CCNA2/CCNB1/AQP1/BAD/TWIST1/SFRP1/BNIP3/ATP6V0D1 19 BP GO:0008643 carbohydrate transport 13/1096 148/18670 0.09534 0.2258 0.1531 ADIPOQ/SLC2A3/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/SLC5A3/SLC23A2/AQP9/INSR/AQP1/SLC2A5 13 BP GO:0097164 ammonium ion metabolic process 17/1096 205/18670 0.09538 0.2258 0.1531 MAOA/MECP2/TGFB2/AKR1B1/CRAT/PNPLA6/GCH1/LIPC/HPRT1/HDC/APOC1/AKR7A2/MOXD1/PLA2G7/AKR1B10/ITGB2/PLA2G15 17 BP GO:0006636 unsaturated fatty acid biosynthetic process 6/1096 54/18670 0.09545 0.2258 0.1531 LTC4S/PTGS1/HPGDS/IL1B/PTGDS/ALOX5 6 BP GO:0030042 actin filament depolymerization 6/1096 54/18670 0.09545 0.2258 0.1531 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/CAPG 6 BP GO:0032728 positive regulation of interferon-beta production 4/1096 30/18670 0.09641 0.2266 0.1537 ZBTB20/IRF1/TLR2/IRF7 4 BP GO:0035066 positive regulation of histone acetylation 4/1096 30/18670 0.09641 0.2266 0.1537 GATA3/IL1B/AUTS2/MAPK3 4 BP GO:0046596 regulation of viral entry into host cell 4/1096 30/18670 0.09641 0.2266 0.1537 FCN1/GSN/MID2/APCS 4 BP GO:0050690 regulation of defense response to virus by virus 4/1096 30/18670 0.09641 0.2266 0.1537 CD247/LCK/PAK2/AP1B1 4 BP GO:0051491 positive regulation of filopodium assembly 4/1096 30/18670 0.09641 0.2266 0.1537 FNBP1L/CCR7/RALA/TENM1 4 BP GO:1904837 beta-catenin-TCF complex assembly 4/1096 30/18670 0.09641 0.2266 0.1537 TCF7/TCF7L2/HDAC1/KAT5 4 BP GO:0062012 regulation of small molecule metabolic process 34/1096 459/18670 0.09672 0.2266 0.1537 FOXO1/ZBTB20/P2RY6/ADIPOQ/ENPP1/PTK2B/NUPR1/IL1B/PLEK/ADIPOR2/SIK1/RGN/NFKB1/PTAFR/PDK2/COX7A1/ABCG1/INSR/APOC1/HIF1A/DYRK2/PINK1/NQO1/NFE2L1/CCNB1/BAD/PMVK/APOE/PHLDA2/HDAC4/DDIT4/TWIST1/PTPN2/NUP210 34 BP GO:0002088 lens development in camera-type eye 8/1096 80/18670 0.09678 0.2266 0.1537 TMOD1/CRYAB/CDON/GATA3/NTRK3/SMAD3/BMP4/CDK4 8 BP GO:0002710 negative regulation of T cell mediated immunity 3/1096 19/18670 0.09699 0.2266 0.1537 IL7R/FCGR2B/PTPRC 3 BP GO:0002726 positive regulation of T cell cytokine production 3/1096 19/18670 0.09699 0.2266 0.1537 GATA3/IL1B/NLRP3 3 BP GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 3/1096 19/18670 0.09699 0.2266 0.1537 PLCB1/GNA11/CHRM3 3 BP GO:0007350 blastoderm segmentation 3/1096 19/18670 0.09699 0.2266 0.1537 SEMA3A/BASP1/NRP2 3 BP GO:0016048 detection of temperature stimulus 3/1096 19/18670 0.09699 0.2266 0.1537 CXCR4/ADORA1/CXCL12 3 BP GO:0032011 ARF protein signal transduction 3/1096 19/18670 0.09699 0.2266 0.1537 MAPRE2/PSD3/PSD4 3 BP GO:0032012 regulation of ARF protein signal transduction 3/1096 19/18670 0.09699 0.2266 0.1537 MAPRE2/PSD3/PSD4 3 BP GO:0032026 response to magnesium ion 3/1096 19/18670 0.09699 0.2266 0.1537 ANK3/CCND1/CD14 3 BP GO:0034138 toll-like receptor 3 signaling pathway 3/1096 19/18670 0.09699 0.2266 0.1537 TNFAIP3/RFTN1/PTPN22 3 BP GO:0034312 diol biosynthetic process 3/1096 19/18670 0.09699 0.2266 0.1537 GCH1/PCBD1/QDPR 3 BP GO:0036303 lymph vessel morphogenesis 3/1096 19/18670 0.09699 0.2266 0.1537 VEGFA/PDPN/FOXC1 3 BP GO:0060004 reflex 3/1096 19/18670 0.09699 0.2266 0.1537 USP46/GLRB/SATB1 3 BP GO:0060438 trachea development 3/1096 19/18670 0.09699 0.2266 0.1537 MAPK3/HOXA5/BMP4 3 BP GO:0060973 cell migration involved in heart development 3/1096 19/18670 0.09699 0.2266 0.1537 SEMA3C/BMP4/TWIST1 3 BP GO:0071800 podosome assembly 3/1096 19/18670 0.09699 0.2266 0.1537 GSN/LCP1/ARHGEF5 3 BP GO:0098581 detection of external biotic stimulus 3/1096 19/18670 0.09699 0.2266 0.1537 LY96/TLR2/LBP 3 BP GO:1901741 positive regulation of myoblast fusion 3/1096 19/18670 0.09699 0.2266 0.1537 IL4R/CD53/TNFSF14 3 BP GO:1902074 response to salt 3/1096 19/18670 0.09699 0.2266 0.1537 DAXX/HSPA5/MAPK13 3 BP GO:1902170 cellular response to reactive nitrogen species 3/1096 19/18670 0.09699 0.2266 0.1537 FOXO1/CCNA2/AQP1 3 BP GO:1902644 tertiary alcohol metabolic process 3/1096 19/18670 0.09699 0.2266 0.1537 AKR1B1/AKR7A2/AKR1B10 3 BP GO:1905939 regulation of gonad development 3/1096 19/18670 0.09699 0.2266 0.1537 SEMA3A/NUPR1/INSR 3 BP GO:2000251 positive regulation of actin cytoskeleton reorganization 3/1096 19/18670 0.09699 0.2266 0.1537 NTRK3/HCLS1/NTF3 3 BP GO:0032387 negative regulation of intracellular transport 7/1096 67/18670 0.0971 0.2267 0.1537 ANGPT1/CRYAB/ADIPOQ/PLN/ARHGAP1/PKIG/UBE2J1 7 BP GO:0043967 histone H4 acetylation 7/1096 67/18670 0.0971 0.2267 0.1537 KAT6B/AUTS2/BRD8/TADA3/MSL3/KAT5/JADE2 7 BP GO:0048469 cell maturation 15/1096 177/18670 0.09778 0.2278 0.1545 MECP2/VEGFA/AXL/GATA3/PTK2B/XBP1/CDC25B/FGFR1/GATA2/HOXA5/HIF1A/CCNB1/CCR6/TRIM58/IL15 15 BP GO:0010559 regulation of glycoprotein biosynthetic process 5/1096 42/18670 0.09788 0.2278 0.1545 PLCB1/HBEGF/TCF7L2/CCR7/IL15 5 BP GO:0010907 positive regulation of glucose metabolic process 5/1096 42/18670 0.09788 0.2278 0.1545 FOXO1/RGN/INSR/DYRK2/PTPN2 5 BP GO:0015701 bicarbonate transport 5/1096 42/18670 0.09788 0.2278 0.1545 CA12/HBB/CYB5R1/AQP1/CA3 5 BP GO:0030517 negative regulation of axon extension 5/1096 42/18670 0.09788 0.2278 0.1545 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F 5 BP GO:1901031 regulation of response to reactive oxygen species 5/1096 42/18670 0.09788 0.2278 0.1545 GCH1/RGN/FBLN5/TRAP1/PINK1 5 BP GO:1903146 regulation of autophagy of mitochondrion 5/1096 42/18670 0.09788 0.2278 0.1545 HK2/HIF1A/PINK1/CTTN/BNIP3 5 BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 13/1096 149/18670 0.09916 0.2307 0.1565 PLCB1/GRK5/CCL5/GPRASP1/RGS1/ADA/PLEK/FZD2/CXCL8/RGS2/RGS13/DNM1/PHB 13 BP GO:0007498 mesoderm development 12/1096 135/18670 0.09926 0.2308 0.1565 VEGFA/SMAD3/SECTM1/SMAD1/FGFR1/BMP4/ETS2/IKZF1/BMPR1A/FOXC1/HOXA11/TCF15 12 BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 12/1096 135/18670 0.09926 0.2308 0.1565 HUWE1/ANGPT1/BIRC3/HSPA5/PTPN22/PIN1/PINK1/NMI/HDAC4/PLK1/WFS1/PTTG1IP 12 BP GO:0030072 peptide hormone secretion 20/1096 250/18670 0.09937 0.2309 0.1566 CCL5/ARL2/EGFR/IL1RN/TCF7L2/IL1B/RBP4/CD38/ICA1/HADH/OXCT1/HIF1A/LTBP4/EFNA5/LRP5/BAD/SLC25A4/SFRP1/INHBB/NNAT 20 BP GO:0006029 proteoglycan metabolic process 9/1096 94/18670 0.1002 0.2327 0.1579 UST/XYLT1/SPOCK2/TCF7L2/SULF1/CHST3/HEXA/UGDH/HYAL1 9 BP GO:0050821 protein stabilization 15/1096 178/18670 0.1013 0.2352 0.1595 CRYAB/STXBP1/SMAD3/PEX19/PIN1/PINK1/CRTAP/PIM1/PHB/HIP1/CAMLG/USP7/PIM2/PFN2/WFS1 15 BP GO:0099003 vesicle-mediated transport in synapse 17/1096 207/18670 0.1019 0.2363 0.1603 STXBP1/STX11/CLSTN1/PRKCB/RAB27A/DNM1/SYT17/PINK1/UNC13B/MAPK10/USP46/RIMS3/SNAP91/KIAA1109/PFN2/PPP3CC/ADCY1 17 BP GO:0002011 morphogenesis of an epithelial sheet 6/1096 55/18670 0.1021 0.2363 0.1603 ARHGAP12/HBEGF/DAG1/CD44/PDPN/ITGA5 6 BP GO:0032781 positive regulation of ATPase activity 6/1096 55/18670 0.1021 0.2363 0.1603 RGN/PLSCR1/ATP4B/MYL3/ATP2A1/PFN2 6 BP GO:0042306 regulation of protein import into nucleus 6/1096 55/18670 0.1021 0.2363 0.1603 ANGPT1/SMAD3/ZIC1/PKIG/HCLS1/BMP4 6 BP GO:0044380 protein localization to cytoskeleton 6/1096 55/18670 0.1021 0.2363 0.1603 MAPRE2/MAPRE3/MID2/SPAG5/DCTN2/STIL 6 BP GO:0046456 icosanoid biosynthetic process 6/1096 55/18670 0.1021 0.2363 0.1603 LTC4S/PTGS1/HPGDS/IL1B/PTGDS/ALOX5 6 BP GO:0046916 cellular transition metal ion homeostasis 10/1096 108/18670 0.1022 0.2363 0.1603 LCK/S100A9/SLC39A8/MT1G/HIF1A/CP/SLC39A14/SLC39A7/TFRC/ATP6V0D1 10 BP GO:0051225 spindle assembly 10/1096 108/18670 0.1022 0.2363 0.1603 MAPRE2/ARHGEF10/KIF3B/GPSM2/MAPRE3/SPAG5/TPX2/PLK1/SPICE1/TUBGCP4 10 BP GO:0071156 regulation of cell cycle arrest 10/1096 108/18670 0.1022 0.2363 0.1603 BIN1/BTG2/CCND1/CNOT1/PLK2/CDK4/CCNB1/CNOT4/CARM1/TFAP4 10 BP GO:1904659 glucose transmembrane transport 10/1096 108/18670 0.1022 0.2363 0.1603 ADIPOQ/SLC2A3/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/SLC5A3/INSR/SLC2A5 10 BP GO:0008203 cholesterol metabolic process 13/1096 150/18670 0.1031 0.2381 0.1615 CH25H/CYB5R3/HDLBP/LIPC/NPC1/ABCG1/APOC1/NFE2L1/LBR/PMVK/APOE/APOF/RXRA 13 BP GO:0002292 T cell differentiation involved in immune response 7/1096 68/18670 0.1031 0.2381 0.1615 IL4R/RELB/GATA3/GPR183/BATF/CD86/NLRP3 7 BP GO:0050891 multicellular organismal water homeostasis 7/1096 68/18670 0.1031 0.2381 0.1615 UGCG/AKR1B1/ADCY9/ADCY6/AQP1/WFS1/ADCY1 7 BP GO:0009165 nucleotide biosynthetic process 29/1096 386/18670 0.1035 0.2389 0.1621 ZBTB20/ADA/NUPR1/NAMPT/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/DCK/PAPSS2/AK1/HDAC4/DDIT4/NME3/AGPAT1/GUK1/IMPDH1/NUP210/IMPDH2/TK2/ALDOA/ADCY1 29 BP GO:0030177 positive regulation of Wnt signaling pathway 15/1096 179/18670 0.1049 0.2418 0.164 TNFAIP3/SEMA5A/EGFR/SMAD3/SULF1/SFRP4/NFKB1/COL1A1/KANK1/PIN1/GPC5/TLR2/SFRP1/PPM1A/MBD2 15 BP GO:0044070 regulation of anion transport 9/1096 95/18670 0.1053 0.2418 0.164 STXBP1/STC1/IL1B/ADORA1/SFRP4/PTAFR/RGS2/FGFR1/APOE 9 BP GO:0110020 regulation of actomyosin structure organization 9/1096 95/18670 0.1053 0.2418 0.164 ARHGEF10/SMAD3/PAK1/S1PR1/CAV3/DLC1/ARHGEF5/SFRP1/PFN2 9 BP GO:0030866 cortical actin cytoskeleton organization 5/1096 43/18670 0.1057 0.2418 0.164 EPB41L1/EPB41L2/PLEK/NCKAP1/NCKAP1L 5 BP GO:0032881 regulation of polysaccharide metabolic process 5/1096 43/18670 0.1057 0.2418 0.164 ENPP1/NFKB1/INSR/DYRK2/PHLDA2 5 BP GO:0033173 calcineurin-NFAT signaling cascade 5/1096 43/18670 0.1057 0.2418 0.164 DYRK2/HOMER3/MAPK7/CAMTA1/PPP3CC 5 BP GO:0042088 T-helper 1 type immune response 5/1096 43/18670 0.1057 0.2418 0.164 IL4R/RELB/IL1B/IL27RA/CCR2 5 BP GO:0045773 positive regulation of axon extension 5/1096 43/18670 0.1057 0.2418 0.164 SEMA5A/VEGFA/NTRK3/PAK1/CXCL12 5 BP GO:0046461 neutral lipid catabolic process 5/1096 43/18670 0.1057 0.2418 0.164 LPL/FABP4/LIPC/PNPLA4/APOE 5 BP GO:0046464 acylglycerol catabolic process 5/1096 43/18670 0.1057 0.2418 0.164 LPL/FABP4/LIPC/PNPLA4/APOE 5 BP GO:0060612 adipose tissue development 5/1096 43/18670 0.1057 0.2418 0.164 FTO/XBP1/OXCT1/CDK4/LRP5 5 BP GO:0070296 sarcoplasmic reticulum calcium ion transport 5/1096 43/18670 0.1057 0.2418 0.164 PLN/NOL3/CCR5/CASQ2/ATP2A1 5 BP GO:1901658 glycosyl compound catabolic process 5/1096 43/18670 0.1057 0.2418 0.164 ADA/HPRT1/AHCY/TYMP/NAGA 5 BP GO:1901985 positive regulation of protein acetylation 5/1096 43/18670 0.1057 0.2418 0.164 GATA3/IL1B/AUTS2/MAPK3/KAT5 5 BP GO:0002082 regulation of oxidative phosphorylation 4/1096 31/18670 0.1058 0.2418 0.164 NUPR1/COX7A1/PINK1/CCNB1 4 BP GO:0007202 activation of phospholipase C activity 4/1096 31/18670 0.1058 0.2418 0.164 P2RY6/EGFR/ITK/S1PR4 4 BP GO:0019098 reproductive behavior 4/1096 31/18670 0.1058 0.2418 0.164 SERPINE2/THRA/HDAC4/MBD2 4 BP GO:0042168 heme metabolic process 4/1096 31/18670 0.1058 0.2418 0.164 BLVRA/NFE2L1/PPOX/UROD 4 BP GO:0044319 wound healing, spreading of cells 4/1096 31/18670 0.1058 0.2418 0.164 HBEGF/CD44/PDPN/ITGA5 4 BP GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 4/1096 31/18670 0.1058 0.2418 0.164 TGFA/ADORA1/PLAUR/HIP1 4 BP GO:0048710 regulation of astrocyte differentiation 4/1096 31/18670 0.1058 0.2418 0.164 SERPINE2/NTRK3/BIN1/ID4 4 BP GO:0090505 epiboly involved in wound healing 4/1096 31/18670 0.1058 0.2418 0.164 HBEGF/CD44/PDPN/ITGA5 4 BP GO:0090659 walking behavior 4/1096 31/18670 0.1058 0.2418 0.164 ZIC1/NPC1/UCHL1/GLRB 4 BP GO:0097106 postsynaptic density organization 4/1096 31/18670 0.1058 0.2418 0.164 LILRB2/NTRK3/SHANK2/CDH2 4 BP GO:0099625 ventricular cardiac muscle cell membrane repolarization 4/1096 31/18670 0.1058 0.2418 0.164 KCNJ8/CAV3/AKAP9/SNTA1 4 BP GO:0099504 synaptic vesicle cycle 16/1096 194/18670 0.107 0.2444 0.1658 MAGI2/STXBP1/STX11/PRKCB/DNM1/SYT17/UNC13B/PCDH17/RIMS3/SNAP91/KIAA1109/CDH2/PFN2/PPP3CC/SLC18A2/ADCY1 16 BP GO:0050684 regulation of mRNA processing 12/1096 137/18670 0.1076 0.2458 0.1667 KHDRBS3/CIRBP/SNRPA/FAM172A/SRPK3/SAP18/PAF1/CCNB1/JMJD6/SRSF8/SREK1/SUPT5H 12 BP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 6/1096 56/18670 0.109 0.2472 0.1676 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:0034381 plasma lipoprotein particle clearance 7/1096 69/18670 0.1093 0.2472 0.1676 ADIPOQ/HDLBP/LIPC/NPC1/APOC1/APOE/CSK 7 BP GO:0050771 negative regulation of axonogenesis 7/1096 69/18670 0.1093 0.2472 0.1676 SPP1/SEMA5A/SEMA3E/SEMA3A/SEMA3C/THY1/SEMA4F 7 BP GO:0071300 cellular response to retinoic acid 7/1096 69/18670 0.1093 0.2472 0.1676 EPHA3/PCK1/NTRK3/PTK2B/COL1A1/FZD7/AQP1 7 BP GO:0002320 lymphoid progenitor cell differentiation 3/1096 20/18670 0.1094 0.2472 0.1676 GATA3/BATF/BMP4 3 BP GO:0002827 positive regulation of T-helper 1 type immune response 3/1096 20/18670 0.1094 0.2472 0.1676 IL1B/IL27RA/CCR2 3 BP GO:0006677 glycosylceramide metabolic process 3/1096 20/18670 0.1094 0.2472 0.1676 UGCG/ALDH5A1/NAGA 3 BP GO:0030903 notochord development 3/1096 20/18670 0.1094 0.2472 0.1676 ID3/COBL/STIL 3 BP GO:0032793 positive regulation of CREB transcription factor activity 3/1096 20/18670 0.1094 0.2472 0.1676 VEGFA/CD200/ADCY1 3 BP GO:0033194 response to hydroperoxide 3/1096 20/18670 0.1094 0.2472 0.1676 GPX3/CD38/GPX1 3 BP GO:0035458 cellular response to interferon-beta 3/1096 20/18670 0.1094 0.2472 0.1676 IRF1/AIM2/STAT1 3 BP GO:0042474 middle ear morphogenesis 3/1096 20/18670 0.1094 0.2472 0.1676 SIX1/FGFR1/OSR2 3 BP GO:0042535 positive regulation of tumor necrosis factor biosynthetic process 3/1096 20/18670 0.1094 0.2472 0.1676 HSPB1/CCR2/LBP 3 BP GO:0043586 tongue development 3/1096 20/18670 0.1094 0.2472 0.1676 EGFR/SIX1/HDAC1 3 BP GO:0043691 reverse cholesterol transport 3/1096 20/18670 0.1094 0.2472 0.1676 LIPC/ABCG1/APOE 3 BP GO:0048670 regulation of collateral sprouting 3/1096 20/18670 0.1094 0.2472 0.1676 SPP1/EFNA5/NGF 3 BP GO:0048745 smooth muscle tissue development 3/1096 20/18670 0.1094 0.2472 0.1676 SIX1/BMP4/COL3A1 3 BP GO:0050802 circadian sleep/wake cycle, sleep 3/1096 20/18670 0.1094 0.2472 0.1676 ADA/ADORA1/PTGDS 3 BP GO:0060008 Sertoli cell differentiation 3/1096 20/18670 0.1094 0.2472 0.1676 ICAM1/ATRX/SDC1 3 BP GO:0060602 branch elongation of an epithelium 3/1096 20/18670 0.1094 0.2472 0.1676 SIX1/BMP4/SPRY1 3 BP GO:0090195 chemokine secretion 3/1096 20/18670 0.1094 0.2472 0.1676 IL4R/LPL/POSTN 3 BP GO:0098698 postsynaptic specialization assembly 3/1096 20/18670 0.1094 0.2472 0.1676 NTRK3/SHANK2/GAP43 3 BP GO:1900017 positive regulation of cytokine production involved in inflammatory response 3/1096 20/18670 0.1094 0.2472 0.1676 GPSM3/MYD88/IL17RA 3 BP GO:1901881 positive regulation of protein depolymerization 3/1096 20/18670 0.1094 0.2472 0.1676 SEMA5A/PLEK/STMN2 3 BP GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/1096 20/18670 0.1094 0.2472 0.1676 XBP1/WFS1/HERPUD1 3 BP GO:1903978 regulation of microglial cell activation 3/1096 20/18670 0.1094 0.2472 0.1676 CTSC/PTPRC/CST7 3 BP GO:0016125 sterol metabolic process 14/1096 166/18670 0.11 0.2485 0.1685 CH25H/CYB5R1/CYB5R3/HDLBP/LIPC/NPC1/ABCG1/APOC1/NFE2L1/LBR/PMVK/APOE/APOF/RXRA 14 BP GO:0090288 negative regulation of cellular response to growth factor stimulus 14/1096 166/18670 0.11 0.2485 0.1685 TGFBR3/CXCL13/GATA3/SMAD3/SULF1/HSPA5/PIN1/LDLRAD4/HTRA1/SFRP1/PPM1A/SPRY1/SMAD6/ADAMTSL2 14 BP GO:0001768 establishment of T cell polarity 2/1096 10/18670 0.1133 0.251 0.1702 GSN/CCR7 2 BP GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2/1096 10/18670 0.1133 0.251 0.1702 S1PR1/S1PR4 2 BP GO:0006188 IMP biosynthetic process 2/1096 10/18670 0.1133 0.251 0.1702 AMPD3/HPRT1 2 BP GO:0006570 tyrosine metabolic process 2/1096 10/18670 0.1133 0.251 0.1702 FAH/HPD 2 BP GO:0006930 substrate-dependent cell migration, cell extension 2/1096 10/18670 0.1133 0.251 0.1702 MYH10/CTTN 2 BP GO:0009157 deoxyribonucleoside monophosphate biosynthetic process 2/1096 10/18670 0.1133 0.251 0.1702 DCK/TK2 2 BP GO:0010749 regulation of nitric oxide mediated signal transduction 2/1096 10/18670 0.1133 0.251 0.1702 VEGFA/EGFR 2 BP GO:0019062 virion attachment to host cell 2/1096 10/18670 0.1133 0.251 0.1702 ICAM1/GAS6 2 BP GO:0021924 cell proliferation in external granule layer 2/1096 10/18670 0.1133 0.251 0.1702 RERE/ATF5 2 BP GO:0021930 cerebellar granule cell precursor proliferation 2/1096 10/18670 0.1133 0.251 0.1702 RERE/ATF5 2 BP GO:0030388 fructose 1,6-bisphosphate metabolic process 2/1096 10/18670 0.1133 0.251 0.1702 PFKM/ALDOA 2 BP GO:0031848 protection from non-homologous end joining at telomere 2/1096 10/18670 0.1133 0.251 0.1702 ERCC1/TFIP11 2 BP GO:0032621 interleukin-18 production 2/1096 10/18670 0.1133 0.251 0.1702 TLR2/NLRP3 2 BP GO:0032836 glomerular basement membrane development 2/1096 10/18670 0.1133 0.251 0.1702 SULF1/LAMB2 2 BP GO:0034135 regulation of toll-like receptor 2 signaling pathway 2/1096 10/18670 0.1133 0.251 0.1702 TNFAIP3/MFHAS1 2 BP GO:0034447 very-low-density lipoprotein particle clearance 2/1096 10/18670 0.1133 0.251 0.1702 APOC1/APOE 2 BP GO:0035768 endothelial cell chemotaxis to fibroblast growth factor 2/1096 10/18670 0.1133 0.251 0.1702 CXCL13/FGFR1 2 BP GO:0045657 positive regulation of monocyte differentiation 2/1096 10/18670 0.1133 0.251 0.1702 CTNNBIP1/JUN 2 BP GO:0045713 low-density lipoprotein particle receptor biosynthetic process 2/1096 10/18670 0.1133 0.251 0.1702 ITGAV/ADIPOQ 2 BP GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 2/1096 10/18670 0.1133 0.251 0.1702 TGFA/ADORA1 2 BP GO:0046498 S-adenosylhomocysteine metabolic process 2/1096 10/18670 0.1133 0.251 0.1702 AHCY/AHCYL2 2 BP GO:0046532 regulation of photoreceptor cell differentiation 2/1096 10/18670 0.1133 0.251 0.1702 CRX/DIO3 2 BP GO:0048304 positive regulation of isotype switching to IgG isotypes 2/1096 10/18670 0.1133 0.251 0.1702 CD40/PTPRC 2 BP GO:0050861 positive regulation of B cell receptor signaling pathway 2/1096 10/18670 0.1133 0.251 0.1702 PRKCB/PRKCH 2 BP GO:0051014 actin filament severing 2/1096 10/18670 0.1133 0.251 0.1702 GSN/GMFG 2 BP GO:0051124 synaptic growth at neuromuscular junction 2/1096 10/18670 0.1133 0.251 0.1702 SIX1/SHANK2 2 BP GO:0051593 response to folic acid 2/1096 10/18670 0.1133 0.251 0.1702 GSN/EEF2 2 BP GO:0060033 anatomical structure regression 2/1096 10/18670 0.1133 0.251 0.1702 NINJ1/BMPR1A 2 BP GO:0060346 bone trabecula formation 2/1096 10/18670 0.1133 0.251 0.1702 COL1A1/SFRP1 2 BP GO:0061140 lung secretory cell differentiation 2/1096 10/18670 0.1133 0.251 0.1702 NFIB/HOXA5 2 BP GO:0061299 retina vasculature morphogenesis in camera-type eye 2/1096 10/18670 0.1133 0.251 0.1702 LRP5/COL4A1 2 BP GO:0070099 regulation of chemokine-mediated signaling pathway 2/1096 10/18670 0.1133 0.251 0.1702 CCL5/HIF1A 2 BP GO:0070341 fat cell proliferation 2/1096 10/18670 0.1133 0.251 0.1702 FTO/GATA2 2 BP GO:0070344 regulation of fat cell proliferation 2/1096 10/18670 0.1133 0.251 0.1702 FTO/GATA2 2 BP GO:0075522 IRES-dependent viral translational initiation 2/1096 10/18670 0.1133 0.251 0.1702 PCBP2/EIF3F 2 BP GO:0090037 positive regulation of protein kinase C signaling 2/1096 10/18670 0.1133 0.251 0.1702 VEGFA/CD40 2 BP GO:0097050 type B pancreatic cell apoptotic process 2/1096 10/18670 0.1133 0.251 0.1702 TCF7L2/WFS1 2 BP GO:0098722 asymmetric stem cell division 2/1096 10/18670 0.1133 0.251 0.1702 ZBTB16/SOX5 2 BP GO:0098917 retrograde trans-synaptic signaling 2/1096 10/18670 0.1133 0.251 0.1702 PLCB1/DAG1 2 BP GO:0106049 regulation of cellular response to osmotic stress 2/1096 10/18670 0.1133 0.251 0.1702 EFHD1/BAD 2 BP GO:0110096 cellular response to aldehyde 2/1096 10/18670 0.1133 0.251 0.1702 AKR1B1/AKR1B10 2 BP GO:1901725 regulation of histone deacetylase activity 2/1096 10/18670 0.1133 0.251 0.1702 VEGFA/PINK1 2 BP GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 2/1096 10/18670 0.1133 0.251 0.1702 CPNE1/CASP4 2 BP GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/1096 10/18670 0.1133 0.251 0.1702 EGFR/BMP4 2 BP GO:1903897 regulation of PERK-mediated unfolded protein response 2/1096 10/18670 0.1133 0.251 0.1702 HSPA5/PTPN2 2 BP GO:2000271 positive regulation of fibroblast apoptotic process 2/1096 10/18670 0.1133 0.251 0.1702 STK17B/SFRP1 2 BP GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 2/1096 10/18670 0.1133 0.251 0.1702 CXCL13/FGFR1 2 BP GO:2000665 regulation of interleukin-13 secretion 2/1096 10/18670 0.1133 0.251 0.1702 GATA3/IL17RA 2 BP GO:2001135 regulation of endocytic recycling 2/1096 10/18670 0.1133 0.251 0.1702 ARHGAP1/INPP5F 2 BP GO:1901293 nucleoside phosphate biosynthetic process 29/1096 390/18670 0.1135 0.2513 0.1704 ZBTB20/ADA/NUPR1/NAMPT/PFKM/HK2/ADCY9/TECR/PDK2/AMPD3/INSR/HPRT1/ADCY6/HIF1A/PINK1/DCK/PAPSS2/AK1/HDAC4/DDIT4/NME3/AGPAT1/GUK1/IMPDH1/NUP210/IMPDH2/TK2/ALDOA/ADCY1 29 BP GO:0034105 positive regulation of tissue remodeling 5/1096 44/18670 0.1138 0.2515 0.1706 SPP1/ADAM8/EGFR/TFRC/IL15 5 BP GO:0044060 regulation of endocrine process 5/1096 44/18670 0.1138 0.2515 0.1706 IL1B/FGFR1/F2R/AGTR1/INHBB 5 BP GO:0045601 regulation of endothelial cell differentiation 5/1096 44/18670 0.1138 0.2515 0.1706 VEGFA/IL1B/CDH5/ID1/BMP4 5 BP GO:0050982 detection of mechanical stimulus 5/1096 44/18670 0.1138 0.2515 0.1706 SERPINE2/CXCR4/CAV3/TTN/CXCL12 5 BP GO:0051489 regulation of filopodium assembly 5/1096 44/18670 0.1138 0.2515 0.1706 FNBP1L/CCR7/RALA/TENM1/GAP43 5 BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 5/1096 44/18670 0.1138 0.2515 0.1706 XBP1/HSPA5/UBE2J1/WFS1/HERPUD1 5 BP GO:0015980 energy derivation by oxidation of organic compounds 22/1096 285/18670 0.1154 0.2548 0.1729 MECP2/PPP1R3C/ENPP1/PYGM/PYGB/GFPT1/INSR/TRAP1/ALDH5A1/HIF1A/DYRK2/PINK1/PPP1R2/CCNB1/COX6A2/PPP1R1A/PHLDA2/NDUFB7/NDUFV1/BNIP3/UQCRC1/ETFB 22 BP GO:0001975 response to amphetamine 4/1096 32/18670 0.1156 0.2548 0.1729 ICAM1/RGS2/HPRT1/SLC18A2 4 BP GO:0046039 GTP metabolic process 4/1096 32/18670 0.1156 0.2548 0.1729 AMPD3/NME3/IMPDH1/IMPDH2 4 BP GO:0048741 skeletal muscle fiber development 4/1096 32/18670 0.1156 0.2548 0.1729 SIX1/ACTA1/GPX1/HDAC4 4 BP GO:0090504 epiboly 4/1096 32/18670 0.1156 0.2548 0.1729 HBEGF/CD44/PDPN/ITGA5 4 BP GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/1096 32/18670 0.1156 0.2548 0.1729 XBP1/PTPN2/WFS1/HERPUD1 4 BP GO:0033344 cholesterol efflux 6/1096 57/18670 0.1162 0.2554 0.1732 ADIPOQ/NFKBIA/NPC1/ABCG1/APOC1/APOE 6 BP GO:0043525 positive regulation of neuron apoptotic process 6/1096 57/18670 0.1162 0.2554 0.1732 TGFB2/NUPR1/PIN1/NQO1/HDAC4/JUN 6 BP GO:0045981 positive regulation of nucleotide metabolic process 6/1096 57/18670 0.1162 0.2554 0.1732 ZBTB20/NUPR1/INSR/HIF1A/PINK1/CCNB1 6 BP GO:0048008 platelet-derived growth factor receptor signaling pathway 6/1096 57/18670 0.1162 0.2554 0.1732 VEGFA/ADIPOQ/RAPGEF1/HIP1/PTPN2/PDGFRA 6 BP GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 6/1096 57/18670 0.1162 0.2554 0.1732 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:1900544 positive regulation of purine nucleotide metabolic process 6/1096 57/18670 0.1162 0.2554 0.1732 ZBTB20/NUPR1/INSR/HIF1A/PINK1/CCNB1 6 BP GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 6/1096 57/18670 0.1162 0.2554 0.1732 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:0022037 metencephalon development 10/1096 111/18670 0.1168 0.2567 0.1741 SERPINE2/MECP2/ZNF365/FCGR2B/PAK1/MYH10/HSPA5/B4GALT2/RERE/FOXC1 10 BP GO:0051302 regulation of cell division 14/1096 168/18670 0.118 0.2593 0.1758 TGFA/TGFB2/VEGFA/SVIL/KIF3B/IL1B/CDC25B/BTC/PLK2/PIN1/CETN2/THBS4/PLK1/CDC6 14 BP GO:0010256 endomembrane system organization 32/1096 438/18670 0.1188 0.2609 0.1769 SERPINE2/CXCR4/SRGN/TGFB2/GSN/ANK3/FNBP1L/NDRG1/SYNGR2/PRKCB/UGCG/BIN1/MAPK3/RAB27A/SPTBN1/MYH10/PTPRC/RAB29/PLSCR1/TMED3/DNM1/AR/TRAM2/CAV3/AKAP9/SYNGR1/F2R/CAMSAP2/CCNB1/RAB22A/PLK1/CCNB2 32 BP GO:0050886 endocrine process 8/1096 84/18670 0.1194 0.2619 0.1776 CPA3/GATA3/IL1B/FGFR1/F2R/HSD11B2/AGTR1/INHBB 8 BP GO:0051492 regulation of stress fiber assembly 8/1096 84/18670 0.1194 0.2619 0.1776 ARHGEF10/SMAD3/PAK1/S1PR1/DLC1/ARHGEF5/SFRP1/PFN2 8 BP GO:0035023 regulation of Rho protein signal transduction 12/1096 140/18670 0.1209 0.2651 0.1798 ARHGEF10/DNMBP/ARHGDIB/TNFAIP1/KANK1/F2R/DLC1/APOE/ABR/ARHGEF5/VAV1/COL3A1 12 BP GO:0009119 ribonucleoside metabolic process 9/1096 98/18670 0.1213 0.2651 0.1798 ADA/AMPD3/HPRT1/AHCY/NME3/GUK1/IMPDH1/IMPDH2/AHCYL2 9 BP GO:0099175 regulation of postsynapse organization 9/1096 98/18670 0.1213 0.2651 0.1798 SIPA1L1/LILRB2/NTRK3/FCGR2B/APOE/PDLIM5/CDH2/NRP2/GAP43 9 BP GO:0007626 locomotory behavior 16/1096 198/18670 0.1217 0.2651 0.1798 NOVA1/MECP2/TMOD1/HPGDS/ZIC1/NPC1/HPRT1/B4GALT2/INPP5F/UCHL1/VPS13A/SNCG/APOE/GLRB/CXCL12/SLC18A2 16 BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 11/1096 126/18670 0.1217 0.2651 0.1798 TGFBR3/MAGI2/SMAD3/HSPA5/PIN1/LDLRAD4/HTRA1/SFRP1/PPM1A/SMAD6/ADAMTSL2 11 BP GO:0008645 hexose transmembrane transport 10/1096 112/18670 0.1219 0.2651 0.1798 ADIPOQ/SLC2A3/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/SLC5A3/INSR/SLC2A5 10 BP GO:0032411 positive regulation of transporter activity 10/1096 112/18670 0.1219 0.2651 0.1798 P2RY6/ANK3/RGN/PTAFR/PLCG2/CCR2/AKAP9/PINK1/ATP2A1/CCL2 10 BP GO:0043279 response to alkaloid 10/1096 112/18670 0.1219 0.2651 0.1798 CXCR4/ICAM1/ADA/PTK2B/GOT2/HSPA5/CASQ2/CCNA2/CASP7/UQCRC1 10 BP GO:0048593 camera-type eye morphogenesis 10/1096 112/18670 0.1219 0.2651 0.1798 VEGFA/CDON/RBP4/HIF1A/THY1/BMP4/DIO3/LRP5/TWIST1/RING1 10 BP GO:0018394 peptidyl-lysine acetylation 14/1096 169/18670 0.1222 0.2651 0.1798 MECP2/KAT6B/GATA3/PCGF2/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/JADE2 14 BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 7/1096 71/18670 0.1222 0.2651 0.1798 CCL5/CD40/HCLS1/PECAM1/FGFR3/CRLF1/IL15 7 BP GO:0071479 cellular response to ionizing radiation 7/1096 71/18670 0.1222 0.2651 0.1798 CRYAB/GATA3/NAMPT/TP53BP1/HSPA5/SFRP1/EEF1D 7 BP GO:1904427 positive regulation of calcium ion transmembrane transport 7/1096 71/18670 0.1222 0.2651 0.1798 P2RY6/RGN/PLCG2/F2R/THY1/ATP2A1/CXCL10 7 BP GO:0044275 cellular carbohydrate catabolic process 5/1096 45/18670 0.1222 0.2651 0.1798 GK/PYGM/PYGB/PGD/AOAH 5 BP GO:0048483 autonomic nervous system development 5/1096 45/18670 0.1222 0.2651 0.1798 EGR2/SEMA3A/SIX1/GATA3/NRP2 5 BP GO:0048701 embryonic cranial skeleton morphogenesis 5/1096 45/18670 0.1222 0.2651 0.1798 SIX1/SMAD3/BMP4/TWIST1/PDGFRA 5 BP GO:0009081 branched-chain amino acid metabolic process 3/1096 21/18670 0.1223 0.2651 0.1798 ALDH6A1/BCAT1/BCKDHA 3 BP GO:0009083 branched-chain amino acid catabolic process 3/1096 21/18670 0.1223 0.2651 0.1798 ALDH6A1/BCAT1/BCKDHA 3 BP GO:0010829 negative regulation of glucose transmembrane transport 3/1096 21/18670 0.1223 0.2651 0.1798 ENPP1/PRKCB/IL1B 3 BP GO:0031290 retinal ganglion cell axon guidance 3/1096 21/18670 0.1223 0.2651 0.1798 VEGFA/SEMA4F/EFNA5 3 BP GO:0032674 regulation of interleukin-5 production 3/1096 21/18670 0.1223 0.2651 0.1798 GATA3/IL17RA/NLRP3 3 BP GO:0035357 peroxisome proliferator activated receptor signaling pathway 3/1096 21/18670 0.1223 0.2651 0.1798 LMO3/TWIST1/RXRA 3 BP GO:0035743 CD4-positive, alpha-beta T cell cytokine production 3/1096 21/18670 0.1223 0.2651 0.1798 GATA3/IL1B/NLRP3 3 BP GO:0042403 thyroid hormone metabolic process 3/1096 21/18670 0.1223 0.2651 0.1798 GATA3/DIO3/CRYM 3 BP GO:0042749 regulation of circadian sleep/wake cycle 3/1096 21/18670 0.1223 0.2651 0.1798 ADA/ADORA1/PTGDS 3 BP GO:0048485 sympathetic nervous system development 3/1096 21/18670 0.1223 0.2651 0.1798 SEMA3A/GATA3/NRP2 3 BP GO:0050951 sensory perception of temperature stimulus 3/1096 21/18670 0.1223 0.2651 0.1798 CXCR4/ADORA1/CXCL12 3 BP GO:0070734 histone H3-K27 methylation 3/1096 21/18670 0.1223 0.2651 0.1798 EZH1/GATA3/EHMT2 3 BP GO:0072111 cell proliferation involved in kidney development 3/1096 21/18670 0.1223 0.2651 0.1798 GATA3/BMP4/STAT1 3 BP GO:1900273 positive regulation of long-term synaptic potentiation 3/1096 21/18670 0.1223 0.2651 0.1798 NRGN/LGMN/ADCY1 3 BP GO:2000269 regulation of fibroblast apoptotic process 3/1096 21/18670 0.1223 0.2651 0.1798 STK17B/GAS6/SFRP1 3 BP GO:0030520 intracellular estrogen receptor signaling pathway 6/1096 58/18670 0.1235 0.2675 0.1815 PAK1/CNOT1/TRIP4/AR/TADA3/CARM1 6 BP GO:0030837 negative regulation of actin filament polymerization 6/1096 58/18670 0.1235 0.2675 0.1815 TMOD1/GSN/SPTBN1/CAPG/KANK1/PFN2 6 BP GO:1903749 positive regulation of establishment of protein localization to mitochondrion 6/1096 58/18670 0.1235 0.2675 0.1815 RAC2/HUWE1/GZMB/PINK1/BAD/PPP3CC 6 BP GO:0051054 positive regulation of DNA metabolic process 18/1096 228/18670 0.1238 0.268 0.1818 MECP2/EGFR/PTK2B/PARM1/CD40/ATRX/TP53BP1/MAPK3/MAP3K4/PTPRC/FGFR1/TNFAIP1/ERCC1/PARP3/USP7/FAM168A/TFRC/JUN 18 BP GO:0048562 embryonic organ morphogenesis 22/1096 288/18670 0.1248 0.27 0.1832 SIX1/GATA3/PCGF2/TCF7/SMAD3/ZIC1/RBP4/MAPK3/FZD2/FGFR1/GATA2/HOXA5/HIF1A/BMP4/EFEMP1/TWIST1/ABR/OSR2/PDGFRA/HOXA11/STIL/HYAL1 22 BP GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 21/1096 273/18670 0.1248 0.27 0.1832 TGFB2/ADIPOQ/IL1RN/CLSTN1/ICAM1/CLDN7/ITGAL/CDH5/SPARCL1/ITGA5/EFNA5/PECAM1/MAPK7/PCDH9/SELL/PCDH17/PTPRF/CDH2/ITGB2/TENM1/SELP 21 BP GO:0009411 response to UV 12/1096 141/18670 0.1255 0.2708 0.1837 EGFR/MFAP4/CIRBP/MAP3K4/CCND1/ERCC1/GPX1/AQP1/UBE4B/MAPK13/ELANE/HYAL1 12 BP GO:0010591 regulation of lamellipodium assembly 4/1096 33/18670 0.1258 0.2708 0.1837 RAC2/AUTS2/NCKAP1/HDAC4 4 BP GO:0010737 protein kinase A signaling 4/1096 33/18670 0.1258 0.2708 0.1837 ADIPOQ/LCP1/TTN/MYOM1 4 BP GO:0036314 response to sterol 4/1096 33/18670 0.1258 0.2708 0.1837 DAG1/CCR5/NFE2L1/PMVK 4 BP GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 4/1096 33/18670 0.1258 0.2708 0.1837 TNFAIP3/CDKN2C/TFAP4/PLK1 4 BP GO:0048854 brain morphogenesis 4/1096 33/18670 0.1258 0.2708 0.1837 AKT3/SHANK2/FANCC/CDH2 4 BP GO:0050718 positive regulation of interleukin-1 beta secretion 4/1096 33/18670 0.1258 0.2708 0.1837 LPL/AIM2/LILRA2/NLRP3 4 BP GO:0051194 positive regulation of cofactor metabolic process 4/1096 33/18670 0.1258 0.2708 0.1837 ZBTB20/INSR/HIF1A/ZNF205 4 BP GO:1901186 positive regulation of ERBB signaling pathway 4/1096 33/18670 0.1258 0.2708 0.1837 TGFA/ADORA1/PLAUR/HIP1 4 BP GO:1901223 negative regulation of NIK/NF-kappaB signaling 4/1096 33/18670 0.1258 0.2708 0.1837 LITAF/CPNE1/NLRP3/PPM1A 4 BP GO:1901890 positive regulation of cell junction assembly 4/1096 33/18670 0.1258 0.2708 0.1837 VEGFA/SMAD3/THY1/SFRP1 4 BP GO:1902692 regulation of neuroblast proliferation 4/1096 33/18670 0.1258 0.2708 0.1837 VEGFA/CX3CR1/SMARCD3/HIF1A 4 BP GO:2000758 positive regulation of peptidyl-lysine acetylation 4/1096 33/18670 0.1258 0.2708 0.1837 GATA3/IL1B/AUTS2/MAPK3 4 BP GO:0045727 positive regulation of translation 11/1096 127/18670 0.1267 0.2725 0.1848 CCL5/PTK2B/CIRBP/EEF2/MAPK3/PTAFR/UPF3A/PINK1/CDK4/RXRA/POLDIP3 11 BP GO:0001708 cell fate specification 9/1096 99/18670 0.1269 0.2729 0.1851 CDON/SIX1/NTRK3/MYL2/AR/FGFR1/FZD7/BMPR1A/HOXA11 9 BP GO:0006260 DNA replication 21/1096 274/18670 0.1282 0.2756 0.1869 HMGA1/EGFR/NFIB/ZNF365/REV3L/ATRX/ID3/FGFR1/TNFAIP1/NFIC/NFIX/CCNA2/NFIA/PURA/SLBP/EHMT2/KAT5/PRIM2/TSPYL2/CDC6/JUN 21 BP GO:0032024 positive regulation of insulin secretion 7/1096 72/18670 0.1289 0.277 0.1879 TCF7L2/RBP4/CD38/OXCT1/HIF1A/BAD/NNAT 7 BP GO:0000910 cytokinesis 14/1096 171/18670 0.1307 0.2796 0.1896 ANK3/SVIL/KIF3B/DCTN3/CDC25B/ANXA11/SPTBN1/MYH10/PLK2/PIN1/CETN2/PLK1/JTB/CDC6 14 BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process 14/1096 171/18670 0.1307 0.2796 0.1896 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NME3/IMPDH1/NUP210/IMPDH2/ALDOA 14 BP GO:0016241 regulation of macroautophagy 14/1096 171/18670 0.1307 0.2796 0.1896 PIP4K2B/NUPR1/MAPK3/NPC1/HIF1A/PINK1/UCHL1/PIM2/CAPNS1/BNIP3/NPRL3/IKBKG/ATP6V0D1/SUPT5H 14 BP GO:0014075 response to amine 5/1096 46/18670 0.1309 0.2796 0.1896 ICAM1/ASS1/RGS2/HPRT1/SLC18A2 5 BP GO:0031648 protein destabilization 5/1096 46/18670 0.1309 0.2796 0.1896 GSN/XBP1/ID1/CTSH/PLK1 5 BP GO:0060443 mammary gland morphogenesis 5/1096 46/18670 0.1309 0.2796 0.1896 AR/CAV3/BMP4/LRP5/IGFBP5 5 BP GO:0097720 calcineurin-mediated signaling 5/1096 46/18670 0.1309 0.2796 0.1896 DYRK2/HOMER3/MAPK7/CAMTA1/PPP3CC 5 BP GO:0001658 branching involved in ureteric bud morphogenesis 6/1096 59/18670 0.1311 0.2796 0.1896 VEGFA/SIX1/MAGED1/BMP4/CTNNBIP1/HOXA11 6 BP GO:0032732 positive regulation of interleukin-1 production 6/1096 59/18670 0.1311 0.2796 0.1896 LPL/AIM2/SMAD3/HSPB1/LILRA2/NLRP3 6 BP GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 6/1096 59/18670 0.1311 0.2796 0.1896 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 6/1096 59/18670 0.1311 0.2796 0.1896 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 6/1096 59/18670 0.1311 0.2796 0.1896 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:2000756 regulation of peptidyl-lysine acetylation 6/1096 59/18670 0.1311 0.2796 0.1896 GATA3/IL1B/AUTS2/MAPK3/GATA2/TWIST1 6 BP GO:0051650 establishment of vesicle localization 22/1096 290/18670 0.1313 0.2796 0.1896 TGFA/STXBP1/STX11/RASGRP1/FNBP1L/SERPINA1/PRKCB/KIF3B/RAB27A/CTSC/ITGA4/DNM1/SYT17/PINK1/UNC13B/F8/RIMS3/SNAP91/DCTN2/PFN2/IKBKG/ADCY1 22 BP GO:0034637 cellular carbohydrate biosynthetic process 8/1096 86/18670 0.1316 0.2796 0.1896 PPP1R3C/PCK1/ENPP1/AKR1B1/INSR/DYRK2/GOT1/PCK2 8 BP GO:0048013 ephrin receptor signaling pathway 8/1096 86/18670 0.1316 0.2796 0.1896 SIPA1L1/EPHA3/CHN1/NTRK3/PAK1/DNM1/EFNA5/ARPC3 8 BP GO:0051260 protein homooligomerization 26/1096 351/18670 0.1322 0.2796 0.1896 CD247/CD3D/CRYAB/ADIPOQ/GPX3/PFKM/TP53BP1/PLN/GCH1/TGM2/PAM/NACC2/HPRT1/CD3G/TNFAIP1/ALDH5A1/PCBD1/JMJD6/GBP1/APOE/KCNB2/CBY1/IMPDH2/RXRA/IKBKE/ALDOA 26 BP GO:0006690 icosanoid metabolic process 10/1096 114/18670 0.1326 0.2796 0.1896 LTC4S/PTGS1/HPGDS/IL1B/GPX4/MAPK3/GPX1/TLR2/PTGDS/ALOX5 10 BP GO:0042752 regulation of circadian rhythm 10/1096 114/18670 0.1326 0.2796 0.1896 PHLPP1/ADA/ADORA1/SIK1/GNA11/MAGED1/MAPK10/USP7/PTGDS/ADCY1 10 BP GO:0019827 stem cell population maintenance 13/1096 157/18670 0.133 0.2796 0.1896 FOXO1/LOXL2/CNOT1/GATA2/PAF1/FZD7/POLR2E/FANCC/BMPR1A/POLR2I/CDH2/SFRP1/CUL4A 13 BP GO:0030509 BMP signaling pathway 13/1096 157/18670 0.133 0.2796 0.1896 TGFBR3/SULF1/MAPK3/SFRP4/CDH5/SMAD1/ID1/BMP4/HTRA1/BMPR1A/SFRP1/PPM1A/SMAD6 13 BP GO:0001767 establishment of lymphocyte polarity 2/1096 11/18670 0.1333 0.2796 0.1896 GSN/CCR7 2 BP GO:0001778 plasma membrane repair 2/1096 11/18670 0.1333 0.2796 0.1896 MYH10/CAV3 2 BP GO:0002604 regulation of dendritic cell antigen processing and presentation 2/1096 11/18670 0.1333 0.2796 0.1896 FCGR2B/CCR7 2 BP GO:0002638 negative regulation of immunoglobulin production 2/1096 11/18670 0.1333 0.2796 0.1896 FCGR2B/PARP3 2 BP GO:0002836 positive regulation of response to tumor cell 2/1096 11/18670 0.1333 0.2796 0.1896 CD226/CRTAM 2 BP GO:0002839 positive regulation of immune response to tumor cell 2/1096 11/18670 0.1333 0.2796 0.1896 CD226/CRTAM 2 BP GO:0003264 regulation of cardioblast proliferation 2/1096 11/18670 0.1333 0.2796 0.1896 SIX1/PIM1 2 BP GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/1096 11/18670 0.1333 0.2796 0.1896 HSPA5/SEC63 2 BP GO:0009113 purine nucleobase biosynthetic process 2/1096 11/18670 0.1333 0.2796 0.1896 ADA/HPRT1 2 BP GO:0009151 purine deoxyribonucleotide metabolic process 2/1096 11/18670 0.1333 0.2796 0.1896 ADA/GUK1 2 BP GO:0010172 embryonic body morphogenesis 2/1096 11/18670 0.1333 0.2796 0.1896 CDON/DAG1 2 BP GO:0021534 cell proliferation in hindbrain 2/1096 11/18670 0.1333 0.2796 0.1896 RERE/ATF5 2 BP GO:0021670 lateral ventricle development 2/1096 11/18670 0.1333 0.2796 0.1896 MYH10/AQP1 2 BP GO:0031442 positive regulation of mRNA 3'-end processing 2/1096 11/18670 0.1333 0.2796 0.1896 PAF1/CCNB1 2 BP GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 2/1096 11/18670 0.1333 0.2796 0.1896 PAK1/AR 2 BP GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2/1096 11/18670 0.1333 0.2796 0.1896 ACADS/ETFB 2 BP GO:0035766 cell chemotaxis to fibroblast growth factor 2/1096 11/18670 0.1333 0.2796 0.1896 CXCL13/FGFR1 2 BP GO:0036462 TRAIL-activated apoptotic signaling pathway 2/1096 11/18670 0.1333 0.2796 0.1896 TNFRSF10B/TIMP3 2 BP GO:0042670 retinal cone cell differentiation 2/1096 11/18670 0.1333 0.2796 0.1896 THY1/DIO3 2 BP GO:0043117 positive regulation of vascular permeability 2/1096 11/18670 0.1333 0.2796 0.1896 VEGFA/PTP4A3 2 BP GO:0043129 surfactant homeostasis 2/1096 11/18670 0.1333 0.2796 0.1896 VEGFA/CTSH 2 BP GO:0044793 negative regulation by host of viral process 2/1096 11/18670 0.1333 0.2796 0.1896 APCS/VAPA 2 BP GO:0045060 negative thymic T cell selection 2/1096 11/18670 0.1333 0.2796 0.1896 CCR7/PTPRC 2 BP GO:0045351 type I interferon biosynthetic process 2/1096 11/18670 0.1333 0.2796 0.1896 NMI/IRF7 2 BP GO:0045793 positive regulation of cell size 2/1096 11/18670 0.1333 0.2796 0.1896 AKT3/CDK4 2 BP GO:0046501 protoporphyrinogen IX metabolic process 2/1096 11/18670 0.1333 0.2796 0.1896 PPOX/UROD 2 BP GO:0046549 retinal cone cell development 2/1096 11/18670 0.1333 0.2796 0.1896 THY1/DIO3 2 BP GO:0046689 response to mercury ion 2/1096 11/18670 0.1333 0.2796 0.1896 AQP9/AQP1 2 BP GO:0046886 positive regulation of hormone biosynthetic process 2/1096 11/18670 0.1333 0.2796 0.1896 IL1B/HIF1A 2 BP GO:0048672 positive regulation of collateral sprouting 2/1096 11/18670 0.1333 0.2796 0.1896 EFNA5/NGF 2 BP GO:0051574 positive regulation of histone H3-K9 methylation 2/1096 11/18670 0.1333 0.2796 0.1896 MECP2/JARID2 2 BP GO:0055015 ventricular cardiac muscle cell development 2/1096 11/18670 0.1333 0.2796 0.1896 MYH10/CCNB1 2 BP GO:0060174 limb bud formation 2/1096 11/18670 0.1333 0.2796 0.1896 SEMA3C/PLXNA2 2 BP GO:0060525 prostate glandular acinus development 2/1096 11/18670 0.1333 0.2796 0.1896 SFRP1/RXRA 2 BP GO:0070254 mucus secretion 2/1096 11/18670 0.1333 0.2796 0.1896 ADA/ADORA1 2 BP GO:0070933 histone H4 deacetylation 2/1096 11/18670 0.1333 0.2796 0.1896 HDAC1/HDAC4 2 BP GO:0071803 positive regulation of podosome assembly 2/1096 11/18670 0.1333 0.2796 0.1896 LCP1/ARHGEF5 2 BP GO:0072611 interleukin-13 secretion 2/1096 11/18670 0.1333 0.2796 0.1896 GATA3/IL17RA 2 BP GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/1096 11/18670 0.1333 0.2796 0.1896 HSPA5/WFS1 2 BP GO:1900112 regulation of histone H3-K9 trimethylation 2/1096 11/18670 0.1333 0.2796 0.1896 MECP2/ATRX 2 BP GO:1904847 regulation of cell chemotaxis to fibroblast growth factor 2/1096 11/18670 0.1333 0.2796 0.1896 CXCL13/FGFR1 2 BP GO:1905902 regulation of mesoderm formation 2/1096 11/18670 0.1333 0.2796 0.1896 FGFR1/BMPR1A 2 BP GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/1096 11/18670 0.1333 0.2796 0.1896 HSPA5/ATF6 2 BP GO:2000551 regulation of T-helper 2 cell cytokine production 2/1096 11/18670 0.1333 0.2796 0.1896 GATA3/NLRP3 2 BP GO:1903320 regulation of protein modification by small protein conjugation or removal 18/1096 231/18670 0.1349 0.2816 0.191 TNFAIP3/HUWE1/ANGPT1/BIRC3/DAXX/HSPA5/SASH1/PTPN22/PIN1/PINK1/NMI/CAMLG/HDAC4/PLK1/WFS1/HERPUD1/PTTG1IP/GLMN 18 BP GO:0009145 purine nucleoside triphosphate biosynthetic process 14/1096 172/18670 0.135 0.2816 0.191 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NME3/IMPDH1/NUP210/IMPDH2/ALDOA 14 BP GO:0000717 nucleotide-excision repair, DNA duplex unwinding 3/1096 22/18670 0.1357 0.2816 0.191 CETN2/RAD23B/CUL4A 3 BP GO:0006783 heme biosynthetic process 3/1096 22/18670 0.1357 0.2816 0.191 NFE2L1/PPOX/UROD 3 BP GO:0007398 ectoderm development 3/1096 22/18670 0.1357 0.2816 0.191 ETS2/FZD7/BMPR1A 3 BP GO:0009190 cyclic nucleotide biosynthetic process 3/1096 22/18670 0.1357 0.2816 0.191 ADCY9/ADCY6/ADCY1 3 BP GO:0010884 positive regulation of lipid storage 3/1096 22/18670 0.1357 0.2816 0.191 LPL/NFKB1/IKBKE 3 BP GO:0022010 central nervous system myelination 3/1096 22/18670 0.1357 0.2816 0.191 ASPA/ID4/TLR2 3 BP GO:0031342 negative regulation of cell killing 3/1096 22/18670 0.1357 0.2816 0.191 IL7R/FCGR2B/PTPRC 3 BP GO:0032291 axon ensheathment in central nervous system 3/1096 22/18670 0.1357 0.2816 0.191 ASPA/ID4/TLR2 3 BP GO:0032634 interleukin-5 production 3/1096 22/18670 0.1357 0.2816 0.191 GATA3/IL17RA/NLRP3 3 BP GO:0032656 regulation of interleukin-13 production 3/1096 22/18670 0.1357 0.2816 0.191 GATA3/IL17RA/NLRP3 3 BP GO:0034311 diol metabolic process 3/1096 22/18670 0.1357 0.2816 0.191 GCH1/PCBD1/QDPR 3 BP GO:0035024 negative regulation of Rho protein signal transduction 3/1096 22/18670 0.1357 0.2816 0.191 TNFAIP1/KANK1/DLC1 3 BP GO:0035809 regulation of urine volume 3/1096 22/18670 0.1357 0.2816 0.191 AKR1B1/BTC/ADCY6 3 BP GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 3/1096 22/18670 0.1357 0.2816 0.191 GATA3/SULF1/SPRY1 3 BP GO:0045624 positive regulation of T-helper cell differentiation 3/1096 22/18670 0.1357 0.2816 0.191 IL4R/CD86/NLRP3 3 BP GO:0045663 positive regulation of myoblast differentiation 3/1096 22/18670 0.1357 0.2816 0.191 PLCB1/CDON/TNFSF14 3 BP GO:0046599 regulation of centriole replication 3/1096 22/18670 0.1357 0.2816 0.191 PLK2/SPICE1/STIL 3 BP GO:0051195 negative regulation of cofactor metabolic process 3/1096 22/18670 0.1357 0.2816 0.191 NUPR1/HDAC4/DDIT4 3 BP GO:0052652 cyclic purine nucleotide metabolic process 3/1096 22/18670 0.1357 0.2816 0.191 ADCY9/ADCY6/ADCY1 3 BP GO:0060487 lung epithelial cell differentiation 3/1096 22/18670 0.1357 0.2816 0.191 NFIB/THRA/HOXA5 3 BP GO:0060547 negative regulation of necrotic cell death 3/1096 22/18670 0.1357 0.2816 0.191 BIRC3/NOL3/SLC25A4 3 BP GO:0071404 cellular response to low-density lipoprotein particle stimulus 3/1096 22/18670 0.1357 0.2816 0.191 LPL/NPC1/ITGB2 3 BP GO:0071577 zinc ion transmembrane transport 3/1096 22/18670 0.1357 0.2816 0.191 SLC39A8/SLC39A14/SLC39A7 3 BP GO:1901685 glutathione derivative metabolic process 3/1096 22/18670 0.1357 0.2816 0.191 HPGDS/GSTA4/GSTT1 3 BP GO:1901687 glutathione derivative biosynthetic process 3/1096 22/18670 0.1357 0.2816 0.191 HPGDS/GSTA4/GSTT1 3 BP GO:1903077 negative regulation of protein localization to plasma membrane 3/1096 22/18670 0.1357 0.2816 0.191 GBP1/CSK/LYPLA1 3 BP GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 3/1096 22/18670 0.1357 0.2816 0.191 VEGFA/GATA2/AGTR1 3 BP GO:0072401 signal transduction involved in DNA integrity checkpoint 7/1096 73/18670 0.1358 0.2816 0.191 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1 7 BP GO:0072422 signal transduction involved in DNA damage checkpoint 7/1096 73/18670 0.1358 0.2816 0.191 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1 7 BP GO:1901983 regulation of protein acetylation 7/1096 73/18670 0.1358 0.2816 0.191 GATA3/IL1B/AUTS2/MAPK3/GATA2/KAT5/TWIST1 7 BP GO:0009164 nucleoside catabolic process 4/1096 34/18670 0.1364 0.2816 0.191 ADA/HPRT1/AHCY/TYMP 4 BP GO:0032594 protein transport within lipid bilayer 4/1096 34/18670 0.1364 0.2816 0.191 CLSTN1/RFTN1/HIP1/MAPK10 4 BP GO:0032660 regulation of interleukin-17 production 4/1096 34/18670 0.1364 0.2816 0.191 IL27RA/MYD88/NCKAP1L/IL15 4 BP GO:0034205 amyloid-beta formation 4/1096 34/18670 0.1364 0.2816 0.191 BIN1/ABCG1/PIN1/APOE 4 BP GO:0042558 pteridine-containing compound metabolic process 4/1096 34/18670 0.1364 0.2816 0.191 GCH1/PCBD1/QDPR/MTHFD2 4 BP GO:0070884 regulation of calcineurin-NFAT signaling cascade 4/1096 34/18670 0.1364 0.2816 0.191 DYRK2/HOMER3/MAPK7/CAMTA1 4 BP GO:0071868 cellular response to monoamine stimulus 4/1096 34/18670 0.1364 0.2816 0.191 ADIPOQ/MAPK3/ID1/ADCY6 4 BP GO:0071870 cellular response to catecholamine stimulus 4/1096 34/18670 0.1364 0.2816 0.191 ADIPOQ/MAPK3/ID1/ADCY6 4 BP GO:0098901 regulation of cardiac muscle cell action potential 4/1096 34/18670 0.1364 0.2816 0.191 ANK3/BIN1/CAV3/AKAP9 4 BP GO:0106056 regulation of calcineurin-mediated signaling 4/1096 34/18670 0.1364 0.2816 0.191 DYRK2/HOMER3/MAPK7/CAMTA1 4 BP GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/1096 34/18670 0.1364 0.2816 0.191 TNFAIP3/CDKN2C/TFAP4/PLK1 4 BP GO:0045844 positive regulation of striated muscle tissue development 8/1096 87/18670 0.138 0.2847 0.1931 TGFBR3/CDON/FGFR1/PIN1/BMP4/PIM1/CCNB1/BMPR1A 8 BP GO:0048636 positive regulation of muscle organ development 8/1096 87/18670 0.138 0.2847 0.1931 TGFBR3/CDON/FGFR1/PIN1/BMP4/PIM1/CCNB1/BMPR1A 8 BP GO:0006096 glycolytic process 10/1096 115/18670 0.138 0.2847 0.1931 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/NUP210/ALDOA 10 BP GO:0036294 cellular response to decreased oxygen levels 17/1096 217/18670 0.1383 0.2851 0.1934 ADAM8/VEGFA/NDRG1/PCK1/ICAM1/STC1/NAMPT/NOL3/HIF1A/PINK1/CCNA2/CCNB1/AQP1/BAD/TWIST1/SFRP1/BNIP3 17 BP GO:0090342 regulation of cell aging 6/1096 60/18670 0.1389 0.2864 0.1942 HMGA1/AKT3/NAMPT/PLK2/BMPR1A/TWIST1 6 BP GO:0010469 regulation of signaling receptor activity 14/1096 173/18670 0.1395 0.2874 0.195 TGFA/PTK2B/FCGR2B/SHANK2/ADORA1/LDOC1/CCR2/CAV3/AKAP9/PINK1/SERPINE1/PHLDA2/CCL2/NPTX2 14 BP GO:0010498 proteasomal protein catabolic process 34/1096 477/18670 0.1397 0.2876 0.1951 TRIM2/WWTR1/NUPR1/NEDD4L/RNF144A/HSPA5/TRIB2/PTTG1/PLK2/TNFAIP1/RNF103/PINK1/UCHL1/LAMP3/FBXO9/GPX1/NFE2L1/CCNB1/PCBP2/UBE4B/CAMLG/UBE2J1/USP7/AREL1/APOE/KAT5/RAD23B/PLK1/WFS1/CUL4A/USP5/FBXL14/HERPUD1/GLMN 34 BP GO:0007622 rhythmic behavior 5/1096 47/18670 0.1399 0.2876 0.1951 EGR2/ADA/ADORA1/AHCY/PTGDS 5 BP GO:0030574 collagen catabolic process 5/1096 47/18670 0.1399 0.2876 0.1951 CTSD/ADAMTS2/ADAMTS3/CTSL/MMP15 5 BP GO:0060986 endocrine hormone secretion 5/1096 47/18670 0.1399 0.2876 0.1951 GATA3/IL1B/FGFR1/AGTR1/INHBB 5 BP GO:0070169 positive regulation of biomineral tissue development 5/1096 47/18670 0.1399 0.2876 0.1951 SMAD3/NELL1/BMP4/BMPR1A/OSR2 5 BP GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 5/1096 47/18670 0.1399 0.2876 0.1951 IL1B/FGFR1/MAPK7/PF4/PRDX2 5 BP GO:0030534 adult behavior 12/1096 144/18670 0.14 0.2877 0.1952 MECP2/TMOD1/SHANK2/ZIC1/NPC1/INPP5F/UCHL1/SNCG/USP46/GLRB/PCDH17/CXCL12 12 BP GO:0009142 nucleoside triphosphate biosynthetic process 15/1096 188/18670 0.1408 0.2894 0.1963 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/PINK1/AK1/HDAC4/DDIT4/NME3/IMPDH1/NUP210/IMPDH2/ALDOA 15 BP GO:0098727 maintenance of cell number 13/1096 159/18670 0.1423 0.2923 0.1983 FOXO1/LOXL2/CNOT1/GATA2/PAF1/FZD7/POLR2E/FANCC/BMPR1A/POLR2I/CDH2/SFRP1/CUL4A 13 BP GO:0009064 glutamine family amino acid metabolic process 7/1096 74/18670 0.1429 0.2929 0.1987 MECP2/FAH/ASS1/GOT2/GFPT1/ALDH5A1/GOT1 7 BP GO:0043507 positive regulation of JUN kinase activity 7/1096 74/18670 0.1429 0.2929 0.1987 PTK2B/PAK1/DAXX/MAP3K4/SASH1/MAP4K1/ARHGEF5 7 BP GO:0072078 nephron tubule morphogenesis 7/1096 74/18670 0.1429 0.2929 0.1987 VEGFA/SIX1/GATA3/MAGED1/BMP4/CTNNBIP1/HOXA11 7 BP GO:0072395 signal transduction involved in cell cycle checkpoint 7/1096 74/18670 0.1429 0.2929 0.1987 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1 7 BP GO:0086001 cardiac muscle cell action potential 7/1096 74/18670 0.1429 0.2929 0.1987 ANK3/BIN1/NEDD4L/KCNJ8/CAV3/AKAP9/SNTA1 7 BP GO:0099601 regulation of neurotransmitter receptor activity 7/1096 74/18670 0.1429 0.2929 0.1987 PTK2B/SHANK2/CCR2/AKAP9/PINK1/CCL2/NPTX2 7 BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 10/1096 116/18670 0.1436 0.2941 0.1995 FCN1/RELB/CLEC10A/PAK1/NFKB1/LILRA2/PLCG2/PAK2/NRAS/IKBKG 10 BP GO:0006757 ATP generation from ADP 10/1096 116/18670 0.1436 0.2941 0.1995 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/NUP210/ALDOA 10 BP GO:0007569 cell aging 10/1096 116/18670 0.1436 0.2941 0.1995 HMGA1/ICAM1/AKT3/NAMPT/PLK2/ERCC1/ZMIZ1/SERPINE1/BMPR1A/TWIST1 10 BP GO:0061097 regulation of protein tyrosine kinase activity 8/1096 88/18670 0.1445 0.2955 0.2005 CCL5/TGFA/ADORA1/PTPRC/PAK2/GAS6/THY1/PTPN2 8 BP GO:1901863 positive regulation of muscle tissue development 8/1096 88/18670 0.1445 0.2955 0.2005 TGFBR3/CDON/FGFR1/PIN1/BMP4/PIM1/CCNB1/BMPR1A 8 BP GO:0010522 regulation of calcium ion transport into cytosol 9/1096 102/18670 0.1446 0.2955 0.2005 CORO1A/P2RY6/PTK2B/PLN/PTPN6/CASQ2/F2R/THY1/CXCL10 9 BP GO:0015837 amine transport 9/1096 102/18670 0.1446 0.2955 0.2005 STXBP1/ADORA1/RGS2/AQP9/SYT17/PINK1/SNCG/CXCL12/SLC18A2 9 BP GO:0031330 negative regulation of cellular catabolic process 20/1096 264/18670 0.146 0.2984 0.2024 TIMP4/CIRBP/NUPR1/NAMPT/NELL1/DAP/RGN/NPC1/MYD88/TIMP2/APOC1/PTPN22/PINK1/LAMP3/TIMP3/CAMLG/UBE2J1/USP7/HDAC4/DDIT4 20 BP GO:0030521 androgen receptor signaling pathway 6/1096 61/18670 0.147 0.2992 0.2029 DAXX/AR/HDAC1/PHB/KAT5/SFRP1 6 BP GO:0032370 positive regulation of lipid transport 6/1096 61/18670 0.147 0.2992 0.2029 SPP1/ADIPOQ/IL1B/NFKBIA/ABCG1/APOE 6 BP GO:0045604 regulation of epidermal cell differentiation 6/1096 61/18670 0.147 0.2992 0.2029 SFRP4/CTSL/BMP4/PRKCH/MAFF/FOXC1 6 BP GO:1905953 negative regulation of lipid localization 6/1096 61/18670 0.147 0.2992 0.2029 ITGAV/NFKBIA/NFKB1/ABCG1/APOC1/PTPN2 6 BP GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/1096 61/18670 0.147 0.2992 0.2029 LCK/NUPR1/S100A9/NACC2/BAD/PTPN2 6 BP GO:0002701 negative regulation of production of molecular mediator of immune response 4/1096 35/18670 0.1473 0.2992 0.2029 ANGPT1/TGFB2/FCGR2B/PARP3 4 BP GO:0010259 multicellular organism aging 4/1096 35/18670 0.1473 0.2992 0.2029 CRYAB/ERCC1/SEC63/INPP5D 4 BP GO:0014904 myotube cell development 4/1096 35/18670 0.1473 0.2992 0.2029 SIX1/ACTA1/GPX1/HDAC4 4 BP GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 4/1096 35/18670 0.1473 0.2992 0.2029 CNOT1/HDAC1/PHB/SFRP1 4 BP GO:0051294 establishment of spindle orientation 4/1096 35/18670 0.1473 0.2992 0.2029 GPSM2/MAP4/PLK1/SPRY1 4 BP GO:0051354 negative regulation of oxidoreductase activity 4/1096 35/18670 0.1473 0.2992 0.2029 AOC3/GZMA/NFKB1/CAV3 4 BP GO:0070873 regulation of glycogen metabolic process 4/1096 35/18670 0.1473 0.2992 0.2029 ENPP1/INSR/DYRK2/PHLDA2 4 BP GO:0071312 cellular response to alkaloid 4/1096 35/18670 0.1473 0.2992 0.2029 ICAM1/CASQ2/CCNA2/CASP7 4 BP GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4/1096 35/18670 0.1473 0.2992 0.2029 GZMB/ZNF205/BAD/PPP3CC 4 BP GO:1902991 regulation of amyloid precursor protein catabolic process 4/1096 35/18670 0.1473 0.2992 0.2029 BIN1/ABCG1/PIN1/APOE 4 BP GO:2000785 regulation of autophagosome assembly 4/1096 35/18670 0.1473 0.2992 0.2029 PIP4K2B/NUPR1/PINK1/NPRL3 4 BP GO:0055076 transition metal ion homeostasis 11/1096 131/18670 0.1474 0.2994 0.203 LCK/STEAP1/S100A9/SLC39A8/MT1G/HIF1A/CP/SLC39A14/SLC39A7/TFRC/ATP6V0D1 11 BP GO:0006111 regulation of gluconeogenesis 5/1096 48/18670 0.1491 0.3004 0.2037 FOXO1/ADIPOQ/SIK1/PDK2/PTPN2 5 BP GO:0008038 neuron recognition 5/1096 48/18670 0.1491 0.3004 0.2037 CXCR4/SEMA5A/EPHA3/SEMA3A/GAP43 5 BP GO:0009069 serine family amino acid metabolic process 5/1096 48/18670 0.1491 0.3004 0.2037 CDO1/AHCY/TST/SDS/AHCYL2 5 BP GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 5/1096 48/18670 0.1491 0.3004 0.2037 TGFB2/BMP4/GDF10/BMPR1A/INHBB 5 BP GO:0030865 cortical cytoskeleton organization 5/1096 48/18670 0.1491 0.3004 0.2037 EPB41L1/EPB41L2/PLEK/NCKAP1/NCKAP1L 5 BP GO:0044764 multi-organism cellular process 5/1096 48/18670 0.1491 0.3004 0.2037 CXCR4/BIRC3/CCR5/GAS6/IRF7 5 BP GO:0061647 histone H3-K9 modification 5/1096 48/18670 0.1491 0.3004 0.2037 MECP2/GATA3/ATRX/EHMT2/JARID2 5 BP GO:0101023 vascular endothelial cell proliferation 5/1096 48/18670 0.1491 0.3004 0.2037 AKT3/ITGA4/FGFR1/CCL2/FLT1 5 BP GO:1903727 positive regulation of phospholipid metabolic process 5/1096 48/18670 0.1491 0.3004 0.2037 PTK2B/CCR7/FGFR3/PDGFRA/FLT1 5 BP GO:1905562 regulation of vascular endothelial cell proliferation 5/1096 48/18670 0.1491 0.3004 0.2037 AKT3/ITGA4/FGFR1/CCL2/FLT1 5 BP GO:0006790 sulfur compound metabolic process 27/1096 372/18670 0.1497 0.3004 0.2037 UST/XYLT1/ANGPT1/SPOCK2/HPGDS/ENPP1/GPX4/TECR/PDK2/PC/B4GALT2/CDO1/ALDH5A1/CHST3/GSTA4/GPX1/NFE2L1/PAPSS2/AHCY/PMVK/LPO/HEXA/GSTT1/TST/UGDH/AHCYL2/HYAL1 27 BP GO:0000715 nucleotide-excision repair, DNA damage recognition 3/1096 23/18670 0.1497 0.3004 0.2037 CETN2/RAD23B/CUL4A 3 BP GO:0006541 glutamine metabolic process 3/1096 23/18670 0.1497 0.3004 0.2037 MECP2/GFPT1/ALDH5A1 3 BP GO:0007413 axonal fasciculation 3/1096 23/18670 0.1497 0.3004 0.2037 SEMA5A/EPHA3/SEMA3A 3 BP GO:0007530 sex determination 3/1096 23/18670 0.1497 0.3004 0.2037 MAP3K4/INSR/AR 3 BP GO:0007617 mating behavior 3/1096 23/18670 0.1497 0.3004 0.2037 SERPINE2/THRA/HDAC4 3 BP GO:0009226 nucleotide-sugar biosynthetic process 3/1096 23/18670 0.1497 0.3004 0.2037 GFPT1/MPI/UGDH 3 BP GO:0022410 circadian sleep/wake cycle process 3/1096 23/18670 0.1497 0.3004 0.2037 ADA/ADORA1/PTGDS 3 BP GO:0030539 male genitalia development 3/1096 23/18670 0.1497 0.3004 0.2037 AR/ASB1/PDGFRA 3 BP GO:0032331 negative regulation of chondrocyte differentiation 3/1096 23/18670 0.1497 0.3004 0.2037 PTHLH/BMP4/EFEMP1 3 BP GO:0032753 positive regulation of interleukin-4 production 3/1096 23/18670 0.1497 0.3004 0.2037 GATA3/CD86/NLRP3 3 BP GO:0032799 low-density lipoprotein receptor particle metabolic process 3/1096 23/18670 0.1497 0.3004 0.2037 ITGAV/ADIPOQ/APOE 3 BP GO:0042454 ribonucleoside catabolic process 3/1096 23/18670 0.1497 0.3004 0.2037 ADA/HPRT1/AHCY 3 BP GO:0045821 positive regulation of glycolytic process 3/1096 23/18670 0.1497 0.3004 0.2037 ZBTB20/INSR/HIF1A 3 BP GO:0050995 negative regulation of lipid catabolic process 3/1096 23/18670 0.1497 0.3004 0.2037 IL1B/ADORA1/APOC1 3 BP GO:0051004 regulation of lipoprotein lipase activity 3/1096 23/18670 0.1497 0.3004 0.2037 LPL/LIPC/APOC1 3 BP GO:0051570 regulation of histone H3-K9 methylation 3/1096 23/18670 0.1497 0.3004 0.2037 MECP2/ATRX/JARID2 3 BP GO:0060479 lung cell differentiation 3/1096 23/18670 0.1497 0.3004 0.2037 NFIB/THRA/HOXA5 3 BP GO:0071157 negative regulation of cell cycle arrest 3/1096 23/18670 0.1497 0.3004 0.2037 CCND1/CDK4/TFAP4 3 BP GO:0071305 cellular response to vitamin D 3/1096 23/18670 0.1497 0.3004 0.2037 PIM1/SFRP1/IL15 3 BP GO:0071467 cellular response to pH 3/1096 23/18670 0.1497 0.3004 0.2037 PCK1/GNA11/HYAL1 3 BP GO:0097150 neuronal stem cell population maintenance 3/1096 23/18670 0.1497 0.3004 0.2037 FOXO1/FANCC/CDH2 3 BP GO:0106030 neuron projection fasciculation 3/1096 23/18670 0.1497 0.3004 0.2037 SEMA5A/EPHA3/SEMA3A 3 BP GO:1903861 positive regulation of dendrite extension 3/1096 23/18670 0.1497 0.3004 0.2037 CXCR4/NEDD4L/SYT17 3 BP GO:0001707 mesoderm formation 7/1096 75/18670 0.1502 0.3009 0.2041 SMAD3/SMAD1/FGFR1/BMP4/BMPR1A/FOXC1/HOXA11 7 BP GO:0003281 ventricular septum development 7/1096 75/18670 0.1502 0.3009 0.2041 TGFBR3/TGFB2/GATA3/FZD2/BMP4/NPRL3/SMAD6 7 BP GO:0021536 diencephalon development 7/1096 75/18670 0.1502 0.3009 0.2041 SEMA5A/SEMA3A/PITX1/GATA2/BMP4/BMPR1A/NRP2 7 BP GO:0043242 negative regulation of protein complex disassembly 7/1096 75/18670 0.1502 0.3009 0.2041 TMOD1/GSN/SPTBN1/CAPG/CAMSAP2/SCAF8/STMN2 7 BP GO:1903201 regulation of oxidative stress-induced cell death 7/1096 75/18670 0.1502 0.3009 0.2041 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0009755 hormone-mediated signaling pathway 18/1096 235/18670 0.1505 0.3013 0.2044 THRA/PGRMC2/ADIPOR2/PAK1/DAXX/NR3C2/CNOT1/TRIP4/AR/BMP4/HDAC1/PHB/TADA3/LMO3/KAT5/CARM1/SFRP1/RXRA 18 BP GO:0034766 negative regulation of ion transmembrane transport 9/1096 103/18670 0.1507 0.3014 0.2044 ANK3/BIN1/NEDD4L/PLN/RGS2/CASQ2/KCNAB1/CAV3/TWIST1 9 BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 8/1096 89/18670 0.1512 0.3014 0.2044 RGS1/S1PR1/ADCY9/ADORA1/RGS2/ADCY6/CHRM3/ADCY1 8 BP GO:0032465 regulation of cytokinesis 8/1096 89/18670 0.1512 0.3014 0.2044 SVIL/KIF3B/CDC25B/PLK2/PIN1/CETN2/PLK1/CDC6 8 BP GO:0002468 dendritic cell antigen processing and presentation 2/1096 12/18670 0.154 0.3014 0.2044 FCGR2B/CCR7 2 BP GO:0002551 mast cell chemotaxis 2/1096 12/18670 0.154 0.3014 0.2044 RAC2/VEGFA 2 BP GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/1096 12/18670 0.154 0.3014 0.2044 FCGR2B/GPX1 2 BP GO:0002921 negative regulation of humoral immune response 2/1096 12/18670 0.154 0.3014 0.2044 FCGR2B/PTPN6 2 BP GO:0003334 keratinocyte development 2/1096 12/18670 0.154 0.3014 0.2044 FLNB/FOSL2 2 BP GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 2/1096 12/18670 0.154 0.3014 0.2044 BMP4/STAT1 2 BP GO:0006020 inositol metabolic process 2/1096 12/18670 0.154 0.3014 0.2044 MECP2/SLC5A3 2 BP GO:0006983 ER overload response 2/1096 12/18670 0.154 0.3014 0.2044 HSPA5/WFS1 2 BP GO:0009886 post-embryonic animal morphogenesis 2/1096 12/18670 0.154 0.3014 0.2044 ATRX/EFEMP1 2 BP GO:0010623 programmed cell death involved in cell development 2/1096 12/18670 0.154 0.3014 0.2044 IL1B/DNASE1L3 2 BP GO:0010649 regulation of cell communication by electrical coupling 2/1096 12/18670 0.154 0.3014 0.2044 ANK3/CASQ2 2 BP GO:0010960 magnesium ion homeostasis 2/1096 12/18670 0.154 0.3014 0.2044 EGFR/ANK3 2 BP GO:0014831 gastro-intestinal system smooth muscle contraction 2/1096 12/18670 0.154 0.3014 0.2044 SULF1/PTAFR 2 BP GO:0016188 synaptic vesicle maturation 2/1096 12/18670 0.154 0.3014 0.2044 STXBP1/UNC13B 2 BP GO:0019755 one-carbon compound transport 2/1096 12/18670 0.154 0.3014 0.2044 AQP9/AQP1 2 BP GO:0032429 regulation of phospholipase A2 activity 2/1096 12/18670 0.154 0.3014 0.2044 EGFR/AGTR1 2 BP GO:0036005 response to macrophage colony-stimulating factor 2/1096 12/18670 0.154 0.3014 0.2044 TLR2/PTPN2 2 BP GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 2/1096 12/18670 0.154 0.3014 0.2044 TLR2/PTPN2 2 BP GO:0042308 negative regulation of protein import into nucleus 2/1096 12/18670 0.154 0.3014 0.2044 ANGPT1/PKIG 2 BP GO:0042368 vitamin D biosynthetic process 2/1096 12/18670 0.154 0.3014 0.2044 IL1B/NFKB1 2 BP GO:0042416 dopamine biosynthetic process 2/1096 12/18670 0.154 0.3014 0.2044 TGFB2/GCH1 2 BP GO:0043383 negative T cell selection 2/1096 12/18670 0.154 0.3014 0.2044 CCR7/PTPRC 2 BP GO:0046541 saliva secretion 2/1096 12/18670 0.154 0.3014 0.2044 AQP1/CHRM3 2 BP GO:0051132 NK T cell activation 2/1096 12/18670 0.154 0.3014 0.2044 ELF4/IL15 2 BP GO:0051481 negative regulation of cytosolic calcium ion concentration 2/1096 12/18670 0.154 0.3014 0.2044 SMAD3/GOT1 2 BP GO:0051549 positive regulation of keratinocyte migration 2/1096 12/18670 0.154 0.3014 0.2044 MAPRE2/HBEGF 2 BP GO:0051956 negative regulation of amino acid transport 2/1096 12/18670 0.154 0.3014 0.2044 ADORA1/RGS2 2 BP GO:0051988 regulation of attachment of spindle microtubules to kinetochore 2/1096 12/18670 0.154 0.3014 0.2044 CCNB1/SPAG5 2 BP GO:0055062 phosphate ion homeostasis 2/1096 12/18670 0.154 0.3014 0.2044 ENPP1/SFRP4 2 BP GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1096 12/18670 0.154 0.3014 0.2044 BTG2/CNOT1 2 BP GO:0060391 positive regulation of SMAD protein signal transduction 2/1096 12/18670 0.154 0.3014 0.2044 BMP4/BMPR1A 2 BP GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/1096 12/18670 0.154 0.3014 0.2044 LDLRAD4/SMAD6 2 BP GO:0060670 branching involved in labyrinthine layer morphogenesis 2/1096 12/18670 0.154 0.3014 0.2044 SPINT2/ST14 2 BP GO:0060742 epithelial cell differentiation involved in prostate gland development 2/1096 12/18670 0.154 0.3014 0.2044 AR/RXRA 2 BP GO:0060788 ectodermal placode formation 2/1096 12/18670 0.154 0.3014 0.2044 SIX1/HDAC1 2 BP GO:0070493 thrombin-activated receptor signaling pathway 2/1096 12/18670 0.154 0.3014 0.2044 PLEK/F2R 2 BP GO:0071697 ectodermal placode morphogenesis 2/1096 12/18670 0.154 0.3014 0.2044 SIX1/HDAC1 2 BP GO:0072178 nephric duct morphogenesis 2/1096 12/18670 0.154 0.3014 0.2044 GATA3/BMP4 2 BP GO:0072505 divalent inorganic anion homeostasis 2/1096 12/18670 0.154 0.3014 0.2044 ENPP1/SFRP4 2 BP GO:0072506 trivalent inorganic anion homeostasis 2/1096 12/18670 0.154 0.3014 0.2044 ENPP1/SFRP4 2 BP GO:0072520 seminiferous tubule development 2/1096 12/18670 0.154 0.3014 0.2044 ATRX/AR 2 BP GO:0072578 neurotransmitter-gated ion channel clustering 2/1096 12/18670 0.154 0.3014 0.2044 APOE/GLRB 2 BP GO:0090209 negative regulation of triglyceride metabolic process 2/1096 12/18670 0.154 0.3014 0.2044 SIK1/APOE 2 BP GO:0090331 negative regulation of platelet aggregation 2/1096 12/18670 0.154 0.3014 0.2044 SERPINE2/PRKG1 2 BP GO:0090520 sphingolipid mediated signaling pathway 2/1096 12/18670 0.154 0.3014 0.2044 S1PR1/S1PR4 2 BP GO:0097104 postsynaptic membrane assembly 2/1096 12/18670 0.154 0.3014 0.2044 MAGI2/CDH2 2 BP GO:0097531 mast cell migration 2/1096 12/18670 0.154 0.3014 0.2044 RAC2/VEGFA 2 BP GO:0098885 modification of postsynaptic actin cytoskeleton 2/1096 12/18670 0.154 0.3014 0.2044 MYH10/PFN2 2 BP GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 2/1096 12/18670 0.154 0.3014 0.2044 AKAP9/NPTX2 2 BP GO:0099150 regulation of postsynaptic specialization assembly 2/1096 12/18670 0.154 0.3014 0.2044 NTRK3/GAP43 2 BP GO:0099640 axo-dendritic protein transport 2/1096 12/18670 0.154 0.3014 0.2044 HSPB1/PURA 2 BP GO:0150052 regulation of postsynapse assembly 2/1096 12/18670 0.154 0.3014 0.2044 NTRK3/GAP43 2 BP GO:0150065 regulation of deacetylase activity 2/1096 12/18670 0.154 0.3014 0.2044 VEGFA/PINK1 2 BP GO:1900044 regulation of protein K63-linked ubiquitination 2/1096 12/18670 0.154 0.3014 0.2044 SASH1/PTPN22 2 BP GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/1096 12/18670 0.154 0.3014 0.2044 TRAP1/PINK1 2 BP GO:1902018 negative regulation of cilium assembly 2/1096 12/18670 0.154 0.3014 0.2044 CDK10/MAP4 2 BP GO:1902916 positive regulation of protein polyubiquitination 2/1096 12/18670 0.154 0.3014 0.2044 PTPN22/NMI 2 BP GO:1902950 regulation of dendritic spine maintenance 2/1096 12/18670 0.154 0.3014 0.2044 FCGR2B/APOE 2 BP GO:1904181 positive regulation of membrane depolarization 2/1096 12/18670 0.154 0.3014 0.2044 ANK3/MLLT11 2 BP GO:1904590 negative regulation of protein import 2/1096 12/18670 0.154 0.3014 0.2044 ANGPT1/PKIG 2 BP GO:2000105 positive regulation of DNA-dependent DNA replication 2/1096 12/18670 0.154 0.3014 0.2044 ATRX/FGFR1 2 BP GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/1096 12/18670 0.154 0.3014 0.2044 LPL/POSTN 2 BP GO:2001198 regulation of dendritic cell differentiation 2/1096 12/18670 0.154 0.3014 0.2044 LILRB2/FCGR2B 2 BP GO:0019080 viral gene expression 15/1096 191/18670 0.1542 0.3016 0.2046 CCL5/MID2/RPS5/RPL18/POLR2E/HDAC1/PCBP2/EIF3F/RPLP0/POLR2I/TFAP4/NUP210/RPL13/JUN/SUPT5H 15 BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 6/1096 62/18670 0.1552 0.303 0.2055 TNFAIP3/BIRC3/NFKBIA/PTPN22/IRF7/IKBKG 6 BP GO:0031640 killing of cells of other organism 6/1096 62/18670 0.1552 0.303 0.2055 CCL13/CXCL6/PF4/BAD/GNLY/ELANE 6 BP GO:0032922 circadian regulation of gene expression 6/1096 62/18670 0.1552 0.303 0.2055 HUWE1/RELB/NAMPT/GFPT1/MAGED1/HDAC1 6 BP GO:0044364 disruption of cells of other organism 6/1096 62/18670 0.1552 0.303 0.2055 CCL13/CXCL6/PF4/BAD/GNLY/ELANE 6 BP GO:0070265 necrotic cell death 6/1096 62/18670 0.1552 0.303 0.2055 BIRC3/NOL3/LY96/CD14/SLC25A4/BNIP3 6 BP GO:0042471 ear morphogenesis 10/1096 118/18670 0.1552 0.303 0.2055 SIX1/GATA3/ZIC1/MAPK3/FZD2/FGFR1/GATA2/TWIST1/ABR/OSR2 10 BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9/1096 104/18670 0.157 0.3064 0.2078 TGFBR3/TGFB2/SULF1/CDH5/GOT1/BMP4/GDF10/BMPR1A/INHBB 9 BP GO:0000422 autophagy of mitochondrion 7/1096 76/18670 0.1576 0.3072 0.2084 HK2/GABARAPL1/HIF1A/PINK1/CTTN/WDR45/BNIP3 7 BP GO:0046902 regulation of mitochondrial membrane permeability 7/1096 76/18670 0.1576 0.3072 0.2084 GZMB/HK2/NOL3/ZNF205/BAD/BNIP3/PPP3CC 7 BP GO:0061726 mitochondrion disassembly 7/1096 76/18670 0.1576 0.3072 0.2084 HK2/GABARAPL1/HIF1A/PINK1/CTTN/WDR45/BNIP3 7 BP GO:1901264 carbohydrate derivative transport 7/1096 76/18670 0.1576 0.3072 0.2084 ADA/ADORA1/SLC29A1/ABCG1/SLC25A4/LBP/GUK1 7 BP GO:1901379 regulation of potassium ion transmembrane transport 8/1096 90/18670 0.158 0.3073 0.2084 ANK3/BIN1/NEDD4L/CASQ2/KCNAB1/CAV3/AKAP9/FHL1 8 BP GO:0009201 ribonucleoside triphosphate biosynthetic process 14/1096 177/18670 0.1581 0.3073 0.2084 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NME3/IMPDH1/NUP210/IMPDH2/ALDOA 14 BP GO:0000578 embryonic axis specification 4/1096 36/18670 0.1585 0.3073 0.2084 BASP1/COBL/SMAD6/STIL 4 BP GO:0009112 nucleobase metabolic process 4/1096 36/18670 0.1585 0.3073 0.2084 ALDH6A1/ADA/HPRT1/TYMP 4 BP GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 4/1096 36/18670 0.1585 0.3073 0.2084 PLN/NOL3/CCR5/CASQ2 4 BP GO:0097242 amyloid-beta clearance 4/1096 36/18670 0.1585 0.3073 0.2084 INSR/HDAC1/APOE/ITGB2 4 BP GO:1901099 negative regulation of signal transduction in absence of ligand 4/1096 36/18670 0.1585 0.3073 0.2084 IL1B/MAPK7/PF4/PRDX2 4 BP GO:2000310 regulation of NMDA receptor activity 4/1096 36/18670 0.1585 0.3073 0.2084 PTK2B/CCR2/PINK1/CCL2 4 BP GO:2001171 positive regulation of ATP biosynthetic process 4/1096 36/18670 0.1585 0.3073 0.2084 ZBTB20/INSR/HIF1A/PINK1 4 BP GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/1096 36/18670 0.1585 0.3073 0.2084 IL1B/MAPK7/PF4/PRDX2 4 BP GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 5/1096 49/18670 0.1586 0.3073 0.2084 CPA3/F2R/SLC2A5/HSD11B2/AGTR1 5 BP GO:0008347 glial cell migration 5/1096 49/18670 0.1586 0.3073 0.2084 TGFB2/GPR183/CX3CR1/CCR2/CCL2 5 BP GO:0034260 negative regulation of GTPase activity 5/1096 49/18670 0.1586 0.3073 0.2084 ARL2/RHOH/RGN/SPRY1/AMOT 5 BP GO:0045010 actin nucleation 5/1096 49/18670 0.1586 0.3073 0.2084 CORO1A/GSN/GMFG/NCKAP1/ARPC3 5 BP GO:0051205 protein insertion into membrane 5/1096 49/18670 0.1586 0.3073 0.2084 GZMB/EGFR/TRAM2/BAD/PPP3CC 5 BP GO:0060042 retina morphogenesis in camera-type eye 5/1096 49/18670 0.1586 0.3073 0.2084 CDON/RBP4/THY1/DIO3/LRP5 5 BP GO:1904707 positive regulation of vascular smooth muscle cell proliferation 5/1096 49/18670 0.1586 0.3073 0.2084 P2RY6/PAK1/IGFBP5/BMPR1A/JUN 5 BP GO:1901136 carbohydrate derivative catabolic process 15/1096 192/18670 0.1588 0.3075 0.2086 PDE1A/ADA/SDC1/CD44/AMPD3/HPRT1/AHCY/GPC5/PDE9A/HEXA/AOAH/TYMP/HYAL1/NAGA/NUDT3 15 BP GO:0071456 cellular response to hypoxia 16/1096 207/18670 0.159 0.3079 0.2088 ADAM8/VEGFA/NDRG1/PCK1/ICAM1/STC1/NOL3/HIF1A/PINK1/CCNA2/CCNB1/AQP1/BAD/TWIST1/SFRP1/BNIP3 16 BP GO:0022898 regulation of transmembrane transporter activity 20/1096 268/18670 0.1613 0.3123 0.2118 P2RY6/ANK3/PTK2B/SHANK2/FXYD1/NEDD4L/PLN/RGN/PTAFR/CASQ2/KCNAB1/PLCG2/CCR2/CAV3/AKAP9/PINK1/ATP2A1/TWIST1/CCL2/FHL1 20 BP GO:0007588 excretion 6/1096 63/18670 0.1636 0.3154 0.2139 GRHPR/STC1/ADORA1/NEDD4L/AQP9/AGTR1 6 BP GO:0032371 regulation of sterol transport 6/1096 63/18670 0.1636 0.3154 0.2139 ADIPOQ/NFKBIA/NFKB1/ABCG1/APOC1/APOE 6 BP GO:0032374 regulation of cholesterol transport 6/1096 63/18670 0.1636 0.3154 0.2139 ADIPOQ/NFKBIA/NFKB1/ABCG1/APOC1/APOE 6 BP GO:1904377 positive regulation of protein localization to cell periphery 6/1096 63/18670 0.1636 0.3154 0.2139 EPHA3/EGFR/EPB41L2/GPSM2/SPTBN1/PRKCH 6 BP GO:0002861 regulation of inflammatory response to antigenic stimulus 3/1096 24/18670 0.1641 0.3154 0.2139 FCGR2B/CCR7/GPX1 3 BP GO:0009110 vitamin biosynthetic process 3/1096 24/18670 0.1641 0.3154 0.2139 IL1B/RGN/NFKB1 3 BP GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 3/1096 24/18670 0.1641 0.3154 0.2139 ADIPOQ/HIP1/PTPN2 3 BP GO:0014850 response to muscle activity 3/1096 24/18670 0.1641 0.3154 0.2139 POSTN/GOT2/HIF1A 3 BP GO:0018126 protein hydroxylation 3/1096 24/18670 0.1641 0.3154 0.2139 ASPH/CRTAP/JMJD6 3 BP GO:0034505 tooth mineralization 3/1096 24/18670 0.1641 0.3154 0.2139 FOXO1/ALPL/COL1A1 3 BP GO:0044062 regulation of excretion 3/1096 24/18670 0.1641 0.3154 0.2139 STC1/ADORA1/AGTR1 3 BP GO:0044346 fibroblast apoptotic process 3/1096 24/18670 0.1641 0.3154 0.2139 STK17B/GAS6/SFRP1 3 BP GO:0046697 decidualization 3/1096 24/18670 0.1641 0.3154 0.2139 SPP1/STC1/MAPK3 3 BP GO:0050687 negative regulation of defense response to virus 3/1096 24/18670 0.1641 0.3154 0.2139 PCBP2/HTRA1/IL2RA 3 BP GO:0050996 positive regulation of lipid catabolic process 3/1096 24/18670 0.1641 0.3154 0.2139 IL1B/ADORA1/TWIST1 3 BP GO:0051220 cytoplasmic sequestering of protein 3/1096 24/18670 0.1641 0.3154 0.2139 NFKBIE/DZIP1/NFKBIA 3 BP GO:0062009 secondary palate development 3/1096 24/18670 0.1641 0.3154 0.2139 TGFBR3/TGFB2/FZD2 3 BP GO:1902914 regulation of protein polyubiquitination 3/1096 24/18670 0.1641 0.3154 0.2139 SASH1/PTPN22/NMI 3 BP GO:1904376 negative regulation of protein localization to cell periphery 3/1096 24/18670 0.1641 0.3154 0.2139 GBP1/CSK/LYPLA1 3 BP GO:1905564 positive regulation of vascular endothelial cell proliferation 3/1096 24/18670 0.1641 0.3154 0.2139 AKT3/ITGA4/FGFR1 3 BP GO:0030510 regulation of BMP signaling pathway 8/1096 91/18670 0.1649 0.317 0.215 SULF1/SFRP4/CDH5/BMP4/HTRA1/SFRP1/PPM1A/SMAD6 8 BP GO:0048332 mesoderm morphogenesis 7/1096 77/18670 0.1653 0.3175 0.2154 SMAD3/SMAD1/FGFR1/BMP4/BMPR1A/FOXC1/HOXA11 7 BP GO:0070588 calcium ion transmembrane transport 23/1096 315/18670 0.1654 0.3177 0.2155 PLCB1/CORO1A/P2RY6/ITGAV/LCK/BIN1/PTK2B/CCR7/PLN/PTPN6/RGN/NOL3/CCR5/PTPRC/CASQ2/PLCG2/GAS6/CAV3/F2R/THY1/ATP2A1/PHB/CXCL10 23 BP GO:0051169 nuclear transport 25/1096 346/18670 0.1659 0.3184 0.2159 EGR2/ANGPT1/HMGA1/TCF7L2/IL1B/SMAD3/ZIC1/NFKBIA/DDX39A/UPF3A/PKIG/HCLS1/GAS6/BMP4/SLBP/MX2/PSIP1/CDC40/PPM1A/CASC3/NXF1/NUP210/POLDIP3/SNRPD2/PTTG1IP 25 BP GO:0050773 regulation of dendrite development 12/1096 149/18670 0.166 0.3184 0.2159 SIPA1L1/CUX1/SHANK2/NEDD4L/ID1/DLG5/PLK2/CAMSAP2/APOE/PDLIM5/CARM1/COBL 12 BP GO:1903900 regulation of viral life cycle 12/1096 149/18670 0.166 0.3184 0.2159 FCN1/CCL5/GSN/SLPI/CXCL8/MID2/PLSCR1/ISG20/PC/LAMP3/APCS/VAPA 12 BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 12/1096 149/18670 0.166 0.3184 0.2159 PTK2B/RNF144A/TRIB2/PLK2/CAV3/CAMLG/USP7/RAD23B/PLK1/USP5/HERPUD1/GLMN 12 BP GO:0072089 stem cell proliferation 10/1096 120/18670 0.1672 0.3205 0.2174 SOX5/VEGFA/EML1/PTPRC/CX3CR1/FGFR1/SMARCD3/HIF1A/ID4/PIM1 10 BP GO:0007088 regulation of mitotic nuclear division 13/1096 164/18670 0.1672 0.3205 0.2174 TGFA/ATRX/IL1B/BTC/INSR/PTTG1/PIN1/BMP4/NFE2L1/CCNB1/LRP5/PLK1/CDC6 13 BP GO:0010171 body morphogenesis 5/1096 50/18670 0.1683 0.3221 0.2184 CDON/DAG1/ASPH/COL1A1/PDGFRA 5 BP GO:0032784 regulation of DNA-templated transcription, elongation 5/1096 50/18670 0.1683 0.3221 0.2184 HTATSF1/PAF1/TCEA2/SCAF8/SUPT5H 5 BP GO:0032873 negative regulation of stress-activated MAPK cascade 5/1096 50/18670 0.1683 0.3221 0.2184 FOXO1/PTPN22/PINK1/SFRP1/DUSP3 5 BP GO:0060976 coronary vasculature development 5/1096 50/18670 0.1683 0.3221 0.2184 TGFBR3/VEGFA/MYH10/BMP4/SMAD6 5 BP GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 5/1096 50/18670 0.1683 0.3221 0.2184 FOXO1/PTPN22/PINK1/SFRP1/DUSP3 5 BP GO:0044774 mitotic DNA integrity checkpoint 9/1096 106/18670 0.17 0.324 0.2197 MDC1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1/CDC6 9 BP GO:0051963 regulation of synapse assembly 9/1096 106/18670 0.17 0.324 0.2197 CLSTN1/SIX1/NTRK3/THBS2/DLG5/EFNA5/TLR2/PDLIM5/GAP43 9 BP GO:0007099 centriole replication 4/1096 37/18670 0.17 0.324 0.2197 PLK2/CETN2/SPICE1/STIL 4 BP GO:0030201 heparan sulfate proteoglycan metabolic process 4/1096 37/18670 0.17 0.324 0.2197 XYLT1/TCF7L2/SULF1/UGDH 4 BP GO:0032885 regulation of polysaccharide biosynthetic process 4/1096 37/18670 0.17 0.324 0.2197 ENPP1/NFKB1/INSR/DYRK2 4 BP GO:0032941 secretion by tissue 4/1096 37/18670 0.17 0.324 0.2197 ADA/ADORA1/AQP1/CHRM3 4 BP GO:0045923 positive regulation of fatty acid metabolic process 4/1096 37/18670 0.17 0.324 0.2197 ADIPOQ/IL1B/RGN/TWIST1 4 BP GO:0051567 histone H3-K9 methylation 4/1096 37/18670 0.17 0.324 0.2197 MECP2/ATRX/EHMT2/JARID2 4 BP GO:0060236 regulation of mitotic spindle organization 4/1096 37/18670 0.17 0.324 0.2197 GPSM2/PARP3/TPX2/PLK1 4 BP GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 4/1096 37/18670 0.17 0.324 0.2197 VEGFA/AKT3/PLK2/GATA2 4 BP GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 4/1096 37/18670 0.17 0.324 0.2197 PLN/NOL3/CCR5/CASQ2 4 BP GO:2000142 regulation of DNA-templated transcription, initiation 4/1096 37/18670 0.17 0.324 0.2197 THRA/CTNNBIP1/TWIST1/JUN 4 BP GO:0030032 lamellipodium assembly 6/1096 64/18670 0.1722 0.328 0.2225 RAC2/AUTS2/S1PR1/ABLIM1/NCKAP1/HDAC4 6 BP GO:0043550 regulation of lipid kinase activity 6/1096 64/18670 0.1722 0.328 0.2225 PTK2B/CCR7/EEF1A2/FGFR3/PDGFRA/FLT1 6 BP GO:0008306 associative learning 7/1096 78/18670 0.173 0.3282 0.2226 MECP2/BTG2/B4GALT2/HIF1A/NRGN/LGMN/NPTX2 7 BP GO:0010827 regulation of glucose transmembrane transport 7/1096 78/18670 0.173 0.3282 0.2226 ADIPOQ/ENPP1/PRKCB/IL1B/ADIPOR2/HK2/INSR 7 BP GO:0031016 pancreas development 7/1096 78/18670 0.173 0.3282 0.2226 FOXO1/TCF7L2/XBP1/INSR/BMP4/BAD/WFS1 7 BP GO:0002087 regulation of respiratory gaseous exchange by neurological system process 2/1096 13/18670 0.1753 0.3282 0.2226 MECP2/ADORA1 2 BP GO:0002679 respiratory burst involved in defense response 2/1096 13/18670 0.1753 0.3282 0.2226 LBP/PRDX2 2 BP GO:0002829 negative regulation of type 2 immune response 2/1096 13/18670 0.1753 0.3282 0.2226 IL27RA/CCR2 2 BP GO:0002864 regulation of acute inflammatory response to antigenic stimulus 2/1096 13/18670 0.1753 0.3282 0.2226 FCGR2B/CCR7 2 BP GO:0003084 positive regulation of systemic arterial blood pressure 2/1096 13/18670 0.1753 0.3282 0.2226 ADORA1/HSD11B2 2 BP GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 2/1096 13/18670 0.1753 0.3282 0.2226 ANGPT1/EFNA5 2 BP GO:0007494 midgut development 2/1096 13/18670 0.1753 0.3282 0.2226 EGFR/ASS1 2 BP GO:0009143 nucleoside triphosphate catabolic process 2/1096 13/18670 0.1753 0.3282 0.2226 ENPP1/ADA 2 BP GO:0009635 response to herbicide 2/1096 13/18670 0.1753 0.3282 0.2226 DAXX/MAPK13 2 BP GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 2/1096 13/18670 0.1753 0.3282 0.2226 ADIPOQ/PTPN2 2 BP GO:0010763 positive regulation of fibroblast migration 2/1096 13/18670 0.1753 0.3282 0.2226 DDR2/PAK1 2 BP GO:0014842 regulation of skeletal muscle satellite cell proliferation 2/1096 13/18670 0.1753 0.3282 0.2226 ANGPT1/SIX1 2 BP GO:0019896 axonal transport of mitochondrion 2/1096 13/18670 0.1753 0.3282 0.2226 HIF1A/UCHL1 2 BP GO:0030656 regulation of vitamin metabolic process 2/1096 13/18670 0.1753 0.3282 0.2226 IL1B/NFKB1 2 BP GO:0031115 negative regulation of microtubule polymerization 2/1096 13/18670 0.1753 0.3282 0.2226 CDH5/STMN2 2 BP GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 2/1096 13/18670 0.1753 0.3282 0.2226 RASGRP1/IL1B 2 BP GO:0033605 positive regulation of catecholamine secretion 2/1096 13/18670 0.1753 0.3282 0.2226 PINK1/CXCL12 2 BP GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 2/1096 13/18670 0.1753 0.3282 0.2226 P2RY6/PTAFR 2 BP GO:0035745 T-helper 2 cell cytokine production 2/1096 13/18670 0.1753 0.3282 0.2226 GATA3/NLRP3 2 BP GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/1096 13/18670 0.1753 0.3282 0.2226 INPP5F/PTPN2 2 BP GO:0042538 hyperosmotic salinity response 2/1096 13/18670 0.1753 0.3282 0.2226 AKR1B1/EFHD1 2 BP GO:0043247 telomere maintenance in response to DNA damage 2/1096 13/18670 0.1753 0.3282 0.2226 ERCC1/TFIP11 2 BP GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 2/1096 13/18670 0.1753 0.3282 0.2226 AR/IGFBP5 2 BP GO:0045602 negative regulation of endothelial cell differentiation 2/1096 13/18670 0.1753 0.3282 0.2226 VEGFA/ID1 2 BP GO:0045759 negative regulation of action potential 2/1096 13/18670 0.1753 0.3282 0.2226 BIN1/CAV3 2 BP GO:0046040 IMP metabolic process 2/1096 13/18670 0.1753 0.3282 0.2226 AMPD3/HPRT1 2 BP GO:0047484 regulation of response to osmotic stress 2/1096 13/18670 0.1753 0.3282 0.2226 EFHD1/BAD 2 BP GO:0048681 negative regulation of axon regeneration 2/1096 13/18670 0.1753 0.3282 0.2226 SPP1/INPP5F 2 BP GO:0048711 positive regulation of astrocyte differentiation 2/1096 13/18670 0.1753 0.3282 0.2226 SERPINE2/BIN1 2 BP GO:0048875 chemical homeostasis within a tissue 2/1096 13/18670 0.1753 0.3282 0.2226 VEGFA/CTSH 2 BP GO:0050713 negative regulation of interleukin-1 beta secretion 2/1096 13/18670 0.1753 0.3282 0.2226 TNFAIP3/NLRP3 2 BP GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 2/1096 13/18670 0.1753 0.3282 0.2226 CXCR4/CXCL12 2 BP GO:0051451 myoblast migration 2/1096 13/18670 0.1753 0.3282 0.2226 SIX1/THBS4 2 BP GO:0060100 positive regulation of phagocytosis, engulfment 2/1096 13/18670 0.1753 0.3282 0.2226 GATA2/NCKAP1L 2 BP GO:0060340 positive regulation of type I interferon-mediated signaling pathway 2/1096 13/18670 0.1753 0.3282 0.2226 IRF7/IKBKE 2 BP GO:0060576 intestinal epithelial cell development 2/1096 13/18670 0.1753 0.3282 0.2226 HOXA5/HIF1A 2 BP GO:0061430 bone trabecula morphogenesis 2/1096 13/18670 0.1753 0.3282 0.2226 COL1A1/SFRP1 2 BP GO:0061469 regulation of type B pancreatic cell proliferation 2/1096 13/18670 0.1753 0.3282 0.2226 NUPR1/SFRP1 2 BP GO:0070208 protein heterotrimerization 2/1096 13/18670 0.1753 0.3282 0.2226 ADIPOQ/COL1A1 2 BP GO:0071415 cellular response to purine-containing compound 2/1096 13/18670 0.1753 0.3282 0.2226 P2RY6/CASQ2 2 BP GO:0071696 ectodermal placode development 2/1096 13/18670 0.1753 0.3282 0.2226 SIX1/HDAC1 2 BP GO:0072672 neutrophil extravasation 2/1096 13/18670 0.1753 0.3282 0.2226 ADAM8/PECAM1 2 BP GO:0090179 planar cell polarity pathway involved in neural tube closure 2/1096 13/18670 0.1753 0.3282 0.2226 FZD2/SFRP1 2 BP GO:1902902 negative regulation of autophagosome assembly 2/1096 13/18670 0.1753 0.3282 0.2226 NUPR1/PINK1 2 BP GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/1096 13/18670 0.1753 0.3282 0.2226 HK2/PINK1 2 BP GO:1905155 positive regulation of membrane invagination 2/1096 13/18670 0.1753 0.3282 0.2226 GATA2/NCKAP1L 2 BP GO:2000009 negative regulation of protein localization to cell surface 2/1096 13/18670 0.1753 0.3282 0.2226 NEDD4L/CAV3 2 BP GO:2000194 regulation of female gonad development 2/1096 13/18670 0.1753 0.3282 0.2226 NUPR1/INSR 2 BP GO:0048524 positive regulation of viral process 9/1096 107/18670 0.1766 0.3305 0.2242 CCL5/PC/POLR2E/APOE/POLR2I/TFAP4/VAPA/JUN/SUPT5H 9 BP GO:0062014 negative regulation of small molecule metabolic process 9/1096 107/18670 0.1766 0.3305 0.2242 ADIPOQ/NUPR1/PLEK/SIK1/NFKB1/APOC1/APOE/HDAC4/DDIT4 9 BP GO:0002244 hematopoietic progenitor cell differentiation 13/1096 166/18670 0.1778 0.3325 0.2256 EML1/GATA3/MEOX1/EEF2/PLEK/PTPN6/BATF/PTPRC/GATA2/BMP4/FOXC1/SFRP1/PDGFRA 13 BP GO:0001945 lymph vessel development 3/1096 25/18670 0.1788 0.3325 0.2256 VEGFA/PDPN/FOXC1 3 BP GO:0014829 vascular smooth muscle contraction 3/1096 25/18670 0.1788 0.3325 0.2256 CD38/ACTA2/CHRM3 3 BP GO:0019054 modulation by virus of host process 3/1096 25/18670 0.1788 0.3325 0.2256 NTRK3/BAD/VAPA 3 BP GO:0030325 adrenal gland development 3/1096 25/18670 0.1788 0.3325 0.2256 SMAD3/INSR/PDGFRA 3 BP GO:0030813 positive regulation of nucleotide catabolic process 3/1096 25/18670 0.1788 0.3325 0.2256 ZBTB20/INSR/HIF1A 3 BP GO:0032616 interleukin-13 production 3/1096 25/18670 0.1788 0.3325 0.2256 GATA3/IL17RA/NLRP3 3 BP GO:0044247 cellular polysaccharide catabolic process 3/1096 25/18670 0.1788 0.3325 0.2256 PYGM/PYGB/AOAH 3 BP GO:0045662 negative regulation of myoblast differentiation 3/1096 25/18670 0.1788 0.3325 0.2256 ID3/BMP4/CXCL10 3 BP GO:0051156 glucose 6-phosphate metabolic process 3/1096 25/18670 0.1788 0.3325 0.2256 HK2/NFE2L1/PGD 3 BP GO:0051197 positive regulation of coenzyme metabolic process 3/1096 25/18670 0.1788 0.3325 0.2256 ZBTB20/INSR/HIF1A 3 BP GO:0051560 mitochondrial calcium ion homeostasis 3/1096 25/18670 0.1788 0.3325 0.2256 TGM2/ATP2A1/BNIP3 3 BP GO:0060444 branching involved in mammary gland duct morphogenesis 3/1096 25/18670 0.1788 0.3325 0.2256 AR/CAV3/LRP5 3 BP GO:1903306 negative regulation of regulated secretory pathway 3/1096 25/18670 0.1788 0.3325 0.2256 FCGR2B/CCR2/ABR 3 BP GO:1903859 regulation of dendrite extension 3/1096 25/18670 0.1788 0.3325 0.2256 CXCR4/NEDD4L/SYT17 3 BP GO:1904385 cellular response to angiotensin 3/1096 25/18670 0.1788 0.3325 0.2256 NFKB1/AGTR1/CDC6 3 BP GO:1905809 negative regulation of synapse organization 3/1096 25/18670 0.1788 0.3325 0.2256 LILRB2/TLR2/APOE 3 BP GO:2000353 positive regulation of endothelial cell apoptotic process 3/1096 25/18670 0.1788 0.3325 0.2256 CD40/ITGA4/CCL2 3 BP GO:2000679 positive regulation of transcription regulatory region DNA binding 3/1096 25/18670 0.1788 0.3325 0.2256 GATA3/TWIST1/FOXC1 3 BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 10/1096 122/18670 0.1796 0.3338 0.2264 RNF144A/TRIB2/PLK2/CAMLG/USP7/RAD23B/PLK1/USP5/HERPUD1/GLMN 10 BP GO:1903578 regulation of ATP metabolic process 10/1096 122/18670 0.1796 0.3338 0.2264 ZBTB20/NUPR1/COX7A1/INSR/HIF1A/PINK1/CCNB1/HDAC4/DDIT4/NUP210 10 BP GO:1905477 positive regulation of protein localization to membrane 10/1096 122/18670 0.1796 0.3338 0.2264 GZMB/EPHA3/EGFR/ANK3/PAK1/SPTBN1/BAD/PRKCH/ITGB2/PPP3CC 10 BP GO:0001570 vasculogenesis 7/1096 79/18670 0.1809 0.3354 0.2275 TGFBR3/VEGFA/ITGAV/EMP2/ZMIZ1/GLMN/AMOT 7 BP GO:0006110 regulation of glycolytic process 7/1096 79/18670 0.1809 0.3354 0.2275 ZBTB20/NUPR1/INSR/HIF1A/HDAC4/DDIT4/NUP210 7 BP GO:0031060 regulation of histone methylation 6/1096 65/18670 0.181 0.3354 0.2275 MECP2/GATA3/ATRX/AUTS2/PAF1/JARID2 6 BP GO:0035308 negative regulation of protein dephosphorylation 6/1096 65/18670 0.181 0.3354 0.2275 RGN/MFHAS1/MGAT5/PPP1R2/NCKAP1L/PPP1R1A 6 BP GO:0006457 protein folding 17/1096 227/18670 0.1812 0.3354 0.2275 SACS/CRYAB/MLEC/DNAJB5/BAG1/HSPB1/HSPA5/PEX19/TRAP1/LTBP4/ATF6/CRTAP/HSPB6/RAD23B/APCS/GANAB/WFS1 17 BP GO:0050803 regulation of synapse structure or activity 17/1096 227/18670 0.1812 0.3354 0.2275 SIPA1L1/LILRB2/CLSTN1/SIX1/NTRK3/THBS2/FCGR2B/DAG1/DNM1/DLG5/EFNA5/TLR2/APOE/PDLIM5/CDH2/NRP2/GAP43 17 BP GO:0006778 porphyrin-containing compound metabolic process 4/1096 38/18670 0.1818 0.3354 0.2275 BLVRA/NFE2L1/PPOX/UROD 4 BP GO:0007190 activation of adenylate cyclase activity 4/1096 38/18670 0.1818 0.3354 0.2275 ADCY9/ADORA3/ADCY6/ADCY1 4 BP GO:0009225 nucleotide-sugar metabolic process 4/1096 38/18670 0.1818 0.3354 0.2275 GFPT1/MPI/GUK1/UGDH 4 BP GO:0010831 positive regulation of myotube differentiation 4/1096 38/18670 0.1818 0.3354 0.2275 IL4R/CD53/CAV3/TNFSF14 4 BP GO:0010939 regulation of necrotic cell death 4/1096 38/18670 0.1818 0.3354 0.2275 BIRC3/NOL3/SLC25A4/BNIP3 4 BP GO:0035329 hippo signaling 4/1096 38/18670 0.1818 0.3354 0.2275 WWTR1/DLG5/AMOTL2/AMOT 4 BP GO:0046329 negative regulation of JNK cascade 4/1096 38/18670 0.1818 0.3354 0.2275 PTPN22/PINK1/SFRP1/DUSP3 4 BP GO:0046825 regulation of protein export from nucleus 4/1096 38/18670 0.1818 0.3354 0.2275 TCF7L2/IL1B/GAS6/PPM1A 4 BP GO:0050716 positive regulation of interleukin-1 secretion 4/1096 38/18670 0.1818 0.3354 0.2275 LPL/AIM2/LILRA2/NLRP3 4 BP GO:0051693 actin filament capping 4/1096 38/18670 0.1818 0.3354 0.2275 TMOD1/GSN/SPTBN1/CAPG 4 BP GO:0071867 response to monoamine 4/1096 38/18670 0.1818 0.3354 0.2275 ADIPOQ/MAPK3/ID1/ADCY6 4 BP GO:0071869 response to catecholamine 4/1096 38/18670 0.1818 0.3354 0.2275 ADIPOQ/MAPK3/ID1/ADCY6 4 BP GO:1901021 positive regulation of calcium ion transmembrane transporter activity 4/1096 38/18670 0.1818 0.3354 0.2275 P2RY6/RGN/PLCG2/ATP2A1 4 BP GO:1902742 apoptotic process involved in development 4/1096 38/18670 0.1818 0.3354 0.2275 TNFRSF1B/CRYAB/TGFB2/FOXC1 4 BP GO:1903523 negative regulation of blood circulation 4/1096 38/18670 0.1818 0.3354 0.2275 BIN1/ADORA1/PLN/F2R 4 BP GO:0006520 cellular amino acid metabolic process 26/1096 366/18670 0.1818 0.3354 0.2275 ALDH6A1/MECP2/FAH/ASS1/GOT2/HPD/GFPT1/SLC7A8/BPHL/BCAT1/BCKDHA/CDO1/HDC/ALDH5A1/ASPA/PCBD1/CRTAP/GOT1/NQO1/AHCY/QDPR/CKMT2/CRYM/TST/SDS/AHCYL2 26 BP GO:0006888 ER to Golgi vesicle-mediated transport 16/1096 212/18670 0.1821 0.3358 0.2277 CREB3L2/TGFA/ANK3/SERPINA1/DCTN3/CTSC/SPTBN1/TMED3/GAS6/TEX261/GAS1/KDELR3/F8/KDELR1/DCTN2/VAPA 16 BP GO:0048489 synaptic vesicle transport 12/1096 152/18670 0.1827 0.3366 0.2283 STXBP1/STX11/PRKCB/RAB27A/DNM1/SYT17/PINK1/UNC13B/RIMS3/SNAP91/PFN2/ADCY1 12 BP GO:0097480 establishment of synaptic vesicle localization 12/1096 152/18670 0.1827 0.3366 0.2283 STXBP1/STX11/PRKCB/RAB27A/DNM1/SYT17/PINK1/UNC13B/RIMS3/SNAP91/PFN2/ADCY1 12 BP GO:0009620 response to fungus 5/1096 52/18670 0.1884 0.3465 0.235 RARRES2/S100A9/IL17RA/GNLY/ELANE 5 BP GO:0015872 dopamine transport 5/1096 52/18670 0.1884 0.3465 0.235 SYT17/PINK1/SNCG/CXCL12/SLC18A2 5 BP GO:0045839 negative regulation of mitotic nuclear division 5/1096 52/18670 0.1884 0.3465 0.235 ATRX/PTTG1/BMP4/CCNB1/PLK1 5 BP GO:0055078 sodium ion homeostasis 5/1096 52/18670 0.1884 0.3465 0.235 ADORA1/NEDD4L/ATP4B/AGTR1/C7 5 BP GO:2000179 positive regulation of neural precursor cell proliferation 5/1096 52/18670 0.1884 0.3465 0.235 VEGFA/CDON/CX3CR1/SMARCD3/HIF1A 5 BP GO:0034250 positive regulation of cellular amide metabolic process 12/1096 153/18670 0.1884 0.3465 0.235 CCL5/PTK2B/CIRBP/EEF2/MAPK3/PTAFR/ABCG1/UPF3A/PINK1/CDK4/RXRA/POLDIP3 12 BP GO:0048193 Golgi vesicle transport 26/1096 368/18670 0.1891 0.3477 0.2359 CREB3L2/ATP9A/TGFA/ANK3/SERPINA1/KIF3B/CUX1/DCTN3/CTSC/SPTBN1/TMED3/GAS6/TEX261/GAS1/KDELR3/MYO1B/F8/VPS13A/KDELR1/SGSM2/CSK/ARF3/TAPBP/DCTN2/VAPA/LYPLA1 26 BP GO:0006513 protein monoubiquitination 6/1096 66/18670 0.19 0.3487 0.2365 HUWE1/PCGF2/NEDD4L/PAF1/UBE4B/RING1 6 BP GO:0006687 glycosphingolipid metabolic process 6/1096 66/18670 0.19 0.3487 0.2365 UGCG/ESYT1/ALDH5A1/HEXA/STS/NAGA 6 BP GO:0051785 positive regulation of nuclear division 6/1096 66/18670 0.19 0.3487 0.2365 PLCB1/TGFA/IL1B/BTC/INSR/LRP5 6 BP GO:1901880 negative regulation of protein depolymerization 6/1096 66/18670 0.19 0.3487 0.2365 TMOD1/GSN/SPTBN1/CAPG/CAMSAP2/STMN2 6 BP GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 6/1096 66/18670 0.19 0.3487 0.2365 GZMB/NOL3/ZNF205/BAD/BNIP3/PPP3CC 6 BP GO:1904888 cranial skeletal system development 6/1096 66/18670 0.19 0.3487 0.2365 TGFB2/SIX1/SMAD3/BMP4/TWIST1/PDGFRA 6 BP GO:0001676 long-chain fatty acid metabolic process 9/1096 109/18670 0.1902 0.3488 0.2366 LTC4S/PTGS1/HPGDS/GPX4/MAPK3/PAM/SLC27A2/PTGDS/ALOX5 9 BP GO:0051149 positive regulation of muscle cell differentiation 9/1096 109/18670 0.1902 0.3488 0.2366 IL4R/CDON/CD53/CAV3/PIN1/SMARCD3/BMP4/TNFSF14/CDH2 9 BP GO:0051261 protein depolymerization 9/1096 109/18670 0.1902 0.3488 0.2366 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/ASPH/CAPG/CAMSAP2/STMN2 9 BP GO:0032412 regulation of ion transmembrane transporter activity 19/1096 260/18670 0.1919 0.3517 0.2385 P2RY6/ANK3/PTK2B/SHANK2/FXYD1/NEDD4L/PLN/RGN/PTAFR/CASQ2/KCNAB1/PLCG2/CCR2/CAV3/AKAP9/PINK1/ATP2A1/CCL2/FHL1 19 BP GO:0016571 histone methylation 11/1096 139/18670 0.1937 0.3523 0.239 EZH1/MECP2/GATA3/ATRX/AUTS2/PAF1/EHMT2/FBL/SATB1/JARID2/CARM1 11 BP GO:0045930 negative regulation of mitotic cell cycle 24/1096 338/18670 0.1938 0.3523 0.239 MAGI2/EGFR/MDC1/ATRX/SMAD3/BTG2/CCND1/CNOT1/CDKN2C/NACC2/TIMP2/PTTG1/PLK2/BMP4/GAS1/CDK4/CCNB1/FOXC1/CNOT4/CARM1/PLK1/CCL2/FHL1/CDC6 24 BP GO:0010874 regulation of cholesterol efflux 4/1096 39/18670 0.1939 0.3523 0.239 ADIPOQ/NFKBIA/ABCG1/APOE 4 BP GO:0031062 positive regulation of histone methylation 4/1096 39/18670 0.1939 0.3523 0.239 MECP2/AUTS2/PAF1/JARID2 4 BP GO:0032692 negative regulation of interleukin-1 production 4/1096 39/18670 0.1939 0.3523 0.239 TNFAIP3/CX3CR1/GAS6/NLRP3 4 BP GO:0033146 regulation of intracellular estrogen receptor signaling pathway 4/1096 39/18670 0.1939 0.3523 0.239 PAK1/CNOT1/AR/CARM1 4 BP GO:0043001 Golgi to plasma membrane protein transport 4/1096 39/18670 0.1939 0.3523 0.239 ANK3/SPTBN1/CSK/LYPLA1 4 BP GO:0045911 positive regulation of DNA recombination 4/1096 39/18670 0.1939 0.3523 0.239 CD40/TP53BP1/PTPRC/TFRC 4 BP GO:1904591 positive regulation of protein import 4/1096 39/18670 0.1939 0.3523 0.239 SMAD3/ZIC1/HCLS1/ARHGEF5 4 BP GO:0001556 oocyte maturation 3/1096 26/18670 0.1939 0.3523 0.239 PTK2B/CDC25B/CCNB1 3 BP GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3/1096 26/18670 0.1939 0.3523 0.239 CPA3/F2R/AGTR1 3 BP GO:0006779 porphyrin-containing compound biosynthetic process 3/1096 26/18670 0.1939 0.3523 0.239 NFE2L1/PPOX/UROD 3 BP GO:0007020 microtubule nucleation 3/1096 26/18670 0.1939 0.3523 0.239 MECP2/AKAP9/TUBGCP4 3 BP GO:0021591 ventricular system development 3/1096 26/18670 0.1939 0.3523 0.239 MECP2/MYH10/AQP1 3 BP GO:0030206 chondroitin sulfate biosynthetic process 3/1096 26/18670 0.1939 0.3523 0.239 XYLT1/CHST3/UGDH 3 BP GO:0030318 melanocyte differentiation 3/1096 26/18670 0.1939 0.3523 0.239 ENPP1/RAB27A/GNA11 3 BP GO:0055083 monovalent inorganic anion homeostasis 3/1096 26/18670 0.1939 0.3523 0.239 CA12/ENPP1/SFRP4 3 BP GO:0060074 synapse maturation 3/1096 26/18670 0.1939 0.3523 0.239 CLSTN1/CX3CR1/NFIA 3 BP GO:0080111 DNA demethylation 3/1096 26/18670 0.1939 0.3523 0.239 FTO/GATA3/USP7 3 BP GO:0099632 protein transport within plasma membrane 3/1096 26/18670 0.1939 0.3523 0.239 CLSTN1/HIP1/MAPK10 3 BP GO:0099637 neurotransmitter receptor transport 3/1096 26/18670 0.1939 0.3523 0.239 CLSTN1/HIP1/MAPK10 3 BP GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/1096 26/18670 0.1939 0.3523 0.239 GZMB/BAD/PPP3CC 3 BP GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/1096 26/18670 0.1939 0.3523 0.239 GZMB/BAD/PPP3CC 3 BP GO:1903579 negative regulation of ATP metabolic process 3/1096 26/18670 0.1939 0.3523 0.239 NUPR1/HDAC4/DDIT4 3 BP GO:1905048 regulation of metallopeptidase activity 3/1096 26/18670 0.1939 0.3523 0.239 MAPK3/TIMP2/TIMP3 3 BP GO:0051196 regulation of coenzyme metabolic process 8/1096 95/18670 0.1941 0.3523 0.239 ZBTB20/NUPR1/PDK2/INSR/HIF1A/HDAC4/DDIT4/NUP210 8 BP GO:1903076 regulation of protein localization to plasma membrane 8/1096 95/18670 0.1941 0.3523 0.239 EPHA3/EGFR/SPTBN1/AR/GBP1/PRKCH/CSK/LYPLA1 8 BP GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 8/1096 95/18670 0.1941 0.3523 0.239 PTK2B/RNF144A/TRIB2/PLK2/CAV3/PLK1/USP5/HERPUD1 8 BP GO:0015698 inorganic anion transport 13/1096 169/18670 0.1941 0.3523 0.239 GABRB1/P2RY6/ENPP1/CLIC5/FXYD1/SLC1A4/SFRP4/SLC20A1/PTAFR/FGFR1/SLC20A2/LRRC8B/GLRB 13 BP GO:0061025 membrane fusion 12/1096 154/18670 0.1942 0.3523 0.239 CXCR4/CORO1A/STXBP1/STX11/TAP1/CCR5/GAS6/MX2/TBC1D4/GCA/TAPBP/VAPA 12 BP GO:0006914 autophagy 34/1096 496/18670 0.1958 0.3523 0.239 FOXO1/FNBP1L/PIP4K2B/NUPR1/NAMPT/HK2/XBP1/MAPK3/HSPB1/DAP/S100A9/NPC1/MID2/GABARAPL1/PLK2/PTPN22/HIF1A/PINK1/UCHL1/LAMP3/IRF8/EEF1A2/BAD/VPS13A/PIM2/CAPNS1/CTTN/KAT5/WDR45/BNIP3/NPRL3/IKBKG/ATP6V0D1/SUPT5H 34 BP GO:0061919 process utilizing autophagic mechanism 34/1096 496/18670 0.1958 0.3523 0.239 FOXO1/FNBP1L/PIP4K2B/NUPR1/NAMPT/HK2/XBP1/MAPK3/HSPB1/DAP/S100A9/NPC1/MID2/GABARAPL1/PLK2/PTPN22/HIF1A/PINK1/UCHL1/LAMP3/IRF8/EEF1A2/BAD/VPS13A/PIM2/CAPNS1/CTTN/KAT5/WDR45/BNIP3/NPRL3/IKBKG/ATP6V0D1/SUPT5H 34 BP GO:0019935 cyclic-nucleotide-mediated signaling 16/1096 215/18670 0.1967 0.3523 0.239 PTK2B/ADCY9/PLN/RGS2/PTHLH/ADCY6/MAPK7/AQP1/PF4/PRKG1/APOE/CXCL10/PDE9A/PTGER2/S1PR4/ADCY1 16 BP GO:0002834 regulation of response to tumor cell 2/1096 14/18670 0.1969 0.3523 0.239 CD226/CRTAM 2 BP GO:0002837 regulation of immune response to tumor cell 2/1096 14/18670 0.1969 0.3523 0.239 CD226/CRTAM 2 BP GO:0003128 heart field specification 2/1096 14/18670 0.1969 0.3523 0.239 SMARCD3/BMP4 2 BP GO:0003188 heart valve formation 2/1096 14/18670 0.1969 0.3523 0.239 OLFM1/TWIST1 2 BP GO:0006268 DNA unwinding involved in DNA replication 2/1096 14/18670 0.1969 0.3523 0.239 HMGA1/PURA 2 BP GO:0009071 serine family amino acid catabolic process 2/1096 14/18670 0.1969 0.3523 0.239 CDO1/SDS 2 BP GO:0009214 cyclic nucleotide catabolic process 2/1096 14/18670 0.1969 0.3523 0.239 PDE1A/PDE9A 2 BP GO:0010421 hydrogen peroxide-mediated programmed cell death 2/1096 14/18670 0.1969 0.3523 0.239 TRAP1/PINK1 2 BP GO:0010755 regulation of plasminogen activation 2/1096 14/18670 0.1969 0.3523 0.239 SERPINE2/SERPINE1 2 BP GO:0014841 skeletal muscle satellite cell proliferation 2/1096 14/18670 0.1969 0.3523 0.239 ANGPT1/SIX1 2 BP GO:0014857 regulation of skeletal muscle cell proliferation 2/1096 14/18670 0.1969 0.3523 0.239 ANGPT1/SIX1 2 BP GO:0019081 viral translation 2/1096 14/18670 0.1969 0.3523 0.239 PCBP2/EIF3F 2 BP GO:0021535 cell migration in hindbrain 2/1096 14/18670 0.1969 0.3523 0.239 RERE/PLXNA2 2 BP GO:0030207 chondroitin sulfate catabolic process 2/1096 14/18670 0.1969 0.3523 0.239 HEXA/HYAL1 2 BP GO:0030836 positive regulation of actin filament depolymerization 2/1096 14/18670 0.1969 0.3523 0.239 SEMA5A/PLEK 2 BP GO:0032688 negative regulation of interferon-beta production 2/1096 14/18670 0.1969 0.3523 0.239 RELB/NMI 2 BP GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 2/1096 14/18670 0.1969 0.3523 0.239 LMO3/TWIST1 2 BP GO:0035435 phosphate ion transmembrane transport 2/1096 14/18670 0.1969 0.3523 0.239 SLC20A1/SLC20A2 2 BP GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/1096 14/18670 0.1969 0.3523 0.239 HIP1/PTPN2 2 BP GO:0036295 cellular response to increased oxygen levels 2/1096 14/18670 0.1969 0.3523 0.239 FOXO1/ATP6V0D1 2 BP GO:0036376 sodium ion export across plasma membrane 2/1096 14/18670 0.1969 0.3523 0.239 FXYD1/ATP4B 2 BP GO:0045591 positive regulation of regulatory T cell differentiation 2/1096 14/18670 0.1969 0.3523 0.239 LILRB2/LILRB4 2 BP GO:0045651 positive regulation of macrophage differentiation 2/1096 14/18670 0.1969 0.3523 0.239 HCLS1/PF4 2 BP GO:0046033 AMP metabolic process 2/1096 14/18670 0.1969 0.3523 0.239 AMPD3/AK1 2 BP GO:0051547 regulation of keratinocyte migration 2/1096 14/18670 0.1969 0.3523 0.239 MAPRE2/HBEGF 2 BP GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1096 14/18670 0.1969 0.3523 0.239 BTG2/CNOT1 2 BP GO:0060452 positive regulation of cardiac muscle contraction 2/1096 14/18670 0.1969 0.3523 0.239 RGS2/ATP2A1 2 BP GO:0060732 positive regulation of inositol phosphate biosynthetic process 2/1096 14/18670 0.1969 0.3523 0.239 P2RY6/PTAFR 2 BP GO:0070234 positive regulation of T cell apoptotic process 2/1096 14/18670 0.1969 0.3523 0.239 CCL5/ADAM8 2 BP GO:0072216 positive regulation of metanephros development 2/1096 14/18670 0.1969 0.3523 0.239 ADIPOQ/BASP1 2 BP GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/1096 14/18670 0.1969 0.3523 0.239 LPL/POSTN 2 BP GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 2/1096 14/18670 0.1969 0.3523 0.239 FZD2/SFRP1 2 BP GO:0097468 programmed cell death in response to reactive oxygen species 2/1096 14/18670 0.1969 0.3523 0.239 TRAP1/PINK1 2 BP GO:1900121 negative regulation of receptor binding 2/1096 14/18670 0.1969 0.3523 0.239 ADIPOQ/PTPRF 2 BP GO:1900452 regulation of long-term synaptic depression 2/1096 14/18670 0.1969 0.3523 0.239 LILRB2/ADORA1 2 BP GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 2/1096 14/18670 0.1969 0.3523 0.239 BMP4/BMPR1A 2 BP GO:1901626 regulation of postsynaptic membrane organization 2/1096 14/18670 0.1969 0.3523 0.239 APOE/CDH2 2 BP GO:1901722 regulation of cell proliferation involved in kidney development 2/1096 14/18670 0.1969 0.3523 0.239 GATA3/BMP4 2 BP GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/1096 14/18670 0.1969 0.3523 0.239 TIMP3/SFRP1 2 BP GO:1903351 cellular response to dopamine 2/1096 14/18670 0.1969 0.3523 0.239 MAPK3/ID1 2 BP GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/1096 14/18670 0.1969 0.3523 0.239 HK2/PINK1 2 BP GO:1905049 negative regulation of metallopeptidase activity 2/1096 14/18670 0.1969 0.3523 0.239 TIMP2/TIMP3 2 BP GO:2000345 regulation of hepatocyte proliferation 2/1096 14/18670 0.1969 0.3523 0.239 TNFAIP3/XBP1 2 BP GO:0016126 sterol biosynthetic process 7/1096 81/18670 0.1972 0.3525 0.2391 CH25H/CYB5R1/CYB5R3/ABCG1/LBR/PMVK/APOE 7 BP GO:0030811 regulation of nucleotide catabolic process 7/1096 81/18670 0.1972 0.3525 0.2391 ZBTB20/NUPR1/INSR/HIF1A/HDAC4/DDIT4/NUP210 7 BP GO:2001021 negative regulation of response to DNA damage stimulus 7/1096 81/18670 0.1972 0.3525 0.2391 TP53BP1/CD44/ERCC1/CXCL12/TWIST1/TFIP11/PTTG1IP 7 BP GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 5/1096 53/18670 0.1987 0.355 0.2408 SEMA5A/VEGFA/GATA2/BMP4/AGTR1 5 BP GO:0045840 positive regulation of mitotic nuclear division 5/1096 53/18670 0.1987 0.355 0.2408 TGFA/IL1B/BTC/INSR/LRP5 5 BP GO:0048662 negative regulation of smooth muscle cell proliferation 6/1096 67/18670 0.1991 0.3556 0.2412 TNFAIP3/ADIPOQ/IGFBP5/PRKG1/CTNNBIP1/IL15 6 BP GO:0034504 protein localization to nucleus 19/1096 262/18670 0.2008 0.3585 0.2432 ZBTB16/ANGPT1/ARL2/SIX1/DCLK1/SMAD3/ZIC1/LILRB4/NFKBIA/MFHAS1/PKIG/HCLS1/COL1A1/PAF1/PIN1/BMP4/GBP2/PLK1/PTTG1IP 19 BP GO:0019217 regulation of fatty acid metabolic process 8/1096 96/18670 0.2017 0.3597 0.244 ADIPOQ/IL1B/ADIPOR2/RGN/PDK2/APOC1/NFE2L1/TWIST1 8 BP GO:0090277 positive regulation of peptide hormone secretion 8/1096 96/18670 0.2017 0.3597 0.244 EGFR/TCF7L2/RBP4/CD38/OXCT1/HIF1A/BAD/NNAT 8 BP GO:2001169 regulation of ATP biosynthetic process 8/1096 96/18670 0.2017 0.3597 0.244 ZBTB20/NUPR1/INSR/HIF1A/PINK1/HDAC4/DDIT4/NUP210 8 BP GO:0000086 G2/M transition of mitotic cell cycle 18/1096 247/18670 0.2029 0.3617 0.2454 PLCB1/MECP2/CDK14/DCTN3/CDC25B/CCND1/AKAP9/SMARCD3/CCNA2/CDK4/CCNB1/CETN2/TPX2/DCTN2/PLK1/FHL1/CDC6/CCNB2 18 BP GO:1903509 liposaccharide metabolic process 9/1096 111/18670 0.2043 0.3642 0.247 UGCG/ESYT1/GPAA1/ALDH5A1/PGAP2/HEXA/AOAH/STS/NAGA 9 BP GO:0043535 regulation of blood vessel endothelial cell migration 12/1096 156/18670 0.2061 0.3662 0.2484 MECP2/ANGPT1/VEGFA/AKT3/CD40/HSPB1/FGFR1/PLK2/GATA2/HIF1A/APOE/ANGPT2 12 BP GO:0051053 negative regulation of DNA metabolic process 12/1096 156/18670 0.2061 0.3662 0.2484 ADIPOQ/GATA3/TP53BP1/RGN/GZMA/ERCC1/PARP3/TWIST1/ZNF91/TFIP11/TSPYL2/CDC6 12 BP GO:0001941 postsynaptic membrane organization 4/1096 40/18670 0.2062 0.3662 0.2484 MAGI2/APOE/GLRB/CDH2 4 BP GO:0001990 regulation of systemic arterial blood pressure by hormone 4/1096 40/18670 0.2062 0.3662 0.2484 CPA3/F2R/HSD11B2/AGTR1 4 BP GO:0007618 mating 4/1096 40/18670 0.2062 0.3662 0.2484 SERPINE2/ADA/THRA/HDAC4 4 BP GO:0014046 dopamine secretion 4/1096 40/18670 0.2062 0.3662 0.2484 SYT17/PINK1/SNCG/CXCL12 4 BP GO:0014059 regulation of dopamine secretion 4/1096 40/18670 0.2062 0.3662 0.2484 SYT17/PINK1/SNCG/CXCL12 4 BP GO:0032467 positive regulation of cytokinesis 4/1096 40/18670 0.2062 0.3662 0.2484 SVIL/KIF3B/CDC25B/CDC6 4 BP GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 4/1096 40/18670 0.2062 0.3662 0.2484 P2RY6/F2R/THY1/CXCL10 4 BP GO:0098534 centriole assembly 4/1096 40/18670 0.2062 0.3662 0.2484 PLK2/CETN2/SPICE1/STIL 4 BP GO:2000008 regulation of protein localization to cell surface 4/1096 40/18670 0.2062 0.3662 0.2484 CD247/NEDD4L/TM9SF4/CAV3 4 BP GO:0043543 protein acylation 18/1096 248/18670 0.2076 0.3687 0.25 FOXO1/MECP2/KAT6B/PCK1/GATA3/PCGF2/NUPR1/IL1B/AUTS2/MAPK3/BRD8/GATA2/TADA3/MSL3/KAT5/TWIST1/PPM1A/JADE2 18 BP GO:0045806 negative regulation of endocytosis 6/1096 68/18670 0.2084 0.3691 0.2503 EPHA3/ADIPOQ/FCGR2B/APOC1/TLR2/CSK 6 BP GO:0002720 positive regulation of cytokine production involved in immune response 5/1096 54/18670 0.2093 0.3691 0.2503 CD226/GATA3/IL1B/MAPK3/NLRP3 5 BP GO:0046164 alcohol catabolic process 5/1096 54/18670 0.2093 0.3691 0.2503 GK/ALDH3B1/AKR1B10/APOE/NUDT3 5 BP GO:0097345 mitochondrial outer membrane permeabilization 5/1096 54/18670 0.2093 0.3691 0.2503 GZMB/ZNF205/BAD/BNIP3/PPP3CC 5 BP GO:0000272 polysaccharide catabolic process 3/1096 27/18670 0.2093 0.3691 0.2503 PYGM/PYGB/AOAH 3 BP GO:0006706 steroid catabolic process 3/1096 27/18670 0.2093 0.3691 0.2503 SPP1/APOE/STS 3 BP GO:0006730 one-carbon metabolic process 3/1096 27/18670 0.2093 0.3691 0.2503 AHCY/MTHFD2/AHCYL2 3 BP GO:0006735 NADH regeneration 3/1096 27/18670 0.2093 0.3691 0.2503 PFKM/HK2/ALDOA 3 BP GO:0006829 zinc ion transport 3/1096 27/18670 0.2093 0.3691 0.2503 SLC39A8/SLC39A14/SLC39A7 3 BP GO:0009649 entrainment of circadian clock 3/1096 27/18670 0.2093 0.3691 0.2503 PHLPP1/SIK1/GNA11 3 BP GO:0009651 response to salt stress 3/1096 27/18670 0.2093 0.3691 0.2503 AKR1B1/EFHD1/AQP1 3 BP GO:0015721 bile acid and bile salt transport 3/1096 27/18670 0.2093 0.3691 0.2503 ABCC3/AQP9/RXRA 3 BP GO:0035902 response to immobilization stress 3/1096 27/18670 0.2093 0.3691 0.2503 PTK2B/ERCC1/GOT1 3 BP GO:0043032 positive regulation of macrophage activation 3/1096 27/18670 0.2093 0.3691 0.2503 IL4R/CTSC/LBP 3 BP GO:0046885 regulation of hormone biosynthetic process 3/1096 27/18670 0.2093 0.3691 0.2503 IL1B/NFKB1/HIF1A 3 BP GO:0048799 animal organ maturation 3/1096 27/18670 0.2093 0.3691 0.2503 XYLT1/GATA3/FGFR3 3 BP GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 3/1096 27/18670 0.2093 0.3691 0.2503 IL4R/CD53/TNFSF14 3 BP GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 3/1096 27/18670 0.2093 0.3691 0.2503 CAV3/AKAP9/SNTA1 3 BP GO:0061621 canonical glycolysis 3/1096 27/18670 0.2093 0.3691 0.2503 PFKM/HK2/ALDOA 3 BP GO:0061718 glucose catabolic process to pyruvate 3/1096 27/18670 0.2093 0.3691 0.2503 PFKM/HK2/ALDOA 3 BP GO:0090169 regulation of spindle assembly 3/1096 27/18670 0.2093 0.3691 0.2503 GPSM2/SPAG5/PLK1 3 BP GO:0030316 osteoclast differentiation 8/1096 97/18670 0.2094 0.3691 0.2503 TCTA/LILRB4/GPR183/GAB2/LILRB3/INPP5D/TFRC/SFRP1 8 BP GO:0044773 mitotic DNA damage checkpoint 8/1096 97/18670 0.2094 0.3691 0.2503 MDC1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1 8 BP GO:0060996 dendritic spine development 8/1096 97/18670 0.2094 0.3691 0.2503 SIPA1L1/ZNF365/SHANK2/PAK2/DLG5/PLK2/APOE/PDLIM5 8 BP GO:0140014 mitotic nuclear division 19/1096 264/18670 0.21 0.37 0.251 TGFA/ARHGEF10/KIF3B/ATRX/IL1B/BTC/INSR/PTTG1/PIN1/BMP4/NFE2L1/CCNB1/LRP5/TTN/SPAG5/TPX2/PLK1/SPICE1/CDC6 19 BP GO:0002065 columnar/cuboidal epithelial cell differentiation 9/1096 112/18670 0.2115 0.3726 0.2527 FGFR1/HOXA5/HIF1A/BMP4/B9D1/BAD/SERPINE1/CDH2/RXRA 9 BP GO:0050807 regulation of synapse organization 16/1096 218/18670 0.2118 0.373 0.253 SIPA1L1/LILRB2/CLSTN1/SIX1/NTRK3/THBS2/FCGR2B/DAG1/DLG5/EFNA5/TLR2/APOE/PDLIM5/CDH2/NRP2/GAP43 16 BP GO:0031570 DNA integrity checkpoint 12/1096 157/18670 0.2121 0.3734 0.2533 MDC1/TP53BP1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1/CUL4A/CDC6 12 BP GO:0032368 regulation of lipid transport 10/1096 127/18670 0.2125 0.3739 0.2536 SPP1/ITGAV/ADIPOQ/IL1B/NFKBIA/NFKB1/ABCG1/APOC1/APOE/AGTR1 10 BP GO:1900542 regulation of purine nucleotide metabolic process 11/1096 142/18670 0.2126 0.374 0.2537 ZBTB20/NUPR1/PDK2/COX7A1/INSR/HIF1A/PINK1/CCNB1/HDAC4/DDIT4/NUP210 11 BP GO:0051783 regulation of nuclear division 14/1096 188/18670 0.2155 0.3786 0.2568 PLCB1/TGFA/ATRX/IL1B/BTC/INSR/PTTG1/PIN1/BMP4/NFE2L1/CCNB1/LRP5/PLK1/CDC6 14 BP GO:0043583 ear development 16/1096 219/18670 0.217 0.3786 0.2568 TGFB2/SIX1/GATA3/NTRK3/ZIC1/MAPK3/FZD2/FGFR1/GATA2/BMP4/CCNA2/TWIST1/ABR/OSR2/PVALB/TCF15 16 BP GO:0008088 axo-dendritic transport 6/1096 69/18670 0.2179 0.3786 0.2568 KIF3B/HSPB1/DST/HIF1A/UCHL1/PURA 6 BP GO:0021575 hindbrain morphogenesis 4/1096 41/18670 0.2187 0.3786 0.2568 SERPINE2/ZNF365/HSPA5/DLC1 4 BP GO:0030835 negative regulation of actin filament depolymerization 4/1096 41/18670 0.2187 0.3786 0.2568 TMOD1/GSN/SPTBN1/CAPG 4 BP GO:0043403 skeletal muscle tissue regeneration 4/1096 41/18670 0.2187 0.3786 0.2568 SGCA/DAG1/GPX1/FZD7 4 BP GO:0048286 lung alveolus development 4/1096 41/18670 0.2187 0.3786 0.2568 ADA/HOXA5/BMP4/IGFBP5 4 BP GO:0090317 negative regulation of intracellular protein transport 4/1096 41/18670 0.2187 0.3786 0.2568 ANGPT1/ADIPOQ/PKIG/UBE2J1 4 BP GO:1905209 positive regulation of cardiocyte differentiation 4/1096 41/18670 0.2187 0.3786 0.2568 TGFB2/SEMA3C/PIN1/BMP4 4 BP GO:0000098 sulfur amino acid catabolic process 2/1096 15/18670 0.2189 0.3786 0.2568 CDO1/TST 2 BP GO:0001829 trophectodermal cell differentiation 2/1096 15/18670 0.2189 0.3786 0.2568 HOPX/ADA 2 BP GO:0001921 positive regulation of receptor recycling 2/1096 15/18670 0.2189 0.3786 0.2568 RAB29/INPP5F 2 BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 2/1096 15/18670 0.2189 0.3786 0.2568 TAP1/TAPBP 2 BP GO:0006000 fructose metabolic process 2/1096 15/18670 0.2189 0.3786 0.2568 AKR1B1/ALDOA 2 BP GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 2/1096 15/18670 0.2189 0.3786 0.2568 MECP2/UQCRC1 2 BP GO:0007512 adult heart development 2/1096 15/18670 0.2189 0.3786 0.2568 MYH10/MYH7 2 BP GO:0009415 response to water 2/1096 15/18670 0.2189 0.3786 0.2568 AKR1B1/MAPK10 2 BP GO:0014856 skeletal muscle cell proliferation 2/1096 15/18670 0.2189 0.3786 0.2568 ANGPT1/SIX1 2 BP GO:0017014 protein nitrosylation 2/1096 15/18670 0.2189 0.3786 0.2568 S100A9/SNTA1 2 BP GO:0018119 peptidyl-cysteine S-nitrosylation 2/1096 15/18670 0.2189 0.3786 0.2568 S100A9/SNTA1 2 BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 2/1096 15/18670 0.2189 0.3786 0.2568 TAP1/TAPBP 2 BP GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 2/1096 15/18670 0.2189 0.3786 0.2568 RASGRP1/IL1B 2 BP GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 2/1096 15/18670 0.2189 0.3786 0.2568 CRAT/ACOX2 2 BP GO:0034111 negative regulation of homotypic cell-cell adhesion 2/1096 15/18670 0.2189 0.3786 0.2568 SERPINE2/PRKG1 2 BP GO:0034310 primary alcohol catabolic process 2/1096 15/18670 0.2189 0.3786 0.2568 ALDH3B1/AKR1B10 2 BP GO:0035635 entry of bacterium into host cell 2/1096 15/18670 0.2189 0.3786 0.2568 ITGAV/CXCL8 2 BP GO:0036445 neuronal stem cell division 2/1096 15/18670 0.2189 0.3786 0.2568 SOX5/FGFR1 2 BP GO:0042362 fat-soluble vitamin biosynthetic process 2/1096 15/18670 0.2189 0.3786 0.2568 IL1B/NFKB1 2 BP GO:0042754 negative regulation of circadian rhythm 2/1096 15/18670 0.2189 0.3786 0.2568 ADA/ADORA1 2 BP GO:0042921 glucocorticoid receptor signaling pathway 2/1096 15/18670 0.2189 0.3786 0.2568 PHB/LMO3 2 BP GO:0042976 activation of Janus kinase activity 2/1096 15/18670 0.2189 0.3786 0.2568 CCL5/PTK2B 2 BP GO:0043508 negative regulation of JUN kinase activity 2/1096 15/18670 0.2189 0.3786 0.2568 PTPN22/SFRP1 2 BP GO:0043650 dicarboxylic acid biosynthetic process 2/1096 15/18670 0.2189 0.3786 0.2568 GOT2/GOT1 2 BP GO:0045073 regulation of chemokine biosynthetic process 2/1096 15/18670 0.2189 0.3786 0.2568 IL1B/ELANE 2 BP GO:0045410 positive regulation of interleukin-6 biosynthetic process 2/1096 15/18670 0.2189 0.3786 0.2568 IL1B/PTAFR 2 BP GO:0045838 positive regulation of membrane potential 2/1096 15/18670 0.2189 0.3786 0.2568 ANK3/BAD 2 BP GO:0048172 regulation of short-term neuronal synaptic plasticity 2/1096 15/18670 0.2189 0.3786 0.2568 SYNGR1/UNC13B 2 BP GO:0048368 lateral mesoderm development 2/1096 15/18670 0.2189 0.3786 0.2568 FGFR1/BMPR1A 2 BP GO:0048712 negative regulation of astrocyte differentiation 2/1096 15/18670 0.2189 0.3786 0.2568 NTRK3/ID4 2 BP GO:0051127 positive regulation of actin nucleation 2/1096 15/18670 0.2189 0.3786 0.2568 GSN/NCKAP1 2 BP GO:0055057 neuroblast division 2/1096 15/18670 0.2189 0.3786 0.2568 SOX5/FGFR1 2 BP GO:0060099 regulation of phagocytosis, engulfment 2/1096 15/18670 0.2189 0.3786 0.2568 GATA2/NCKAP1L 2 BP GO:0060841 venous blood vessel development 2/1096 15/18670 0.2189 0.3786 0.2568 VEGFA/SEMA3C 2 BP GO:0070365 hepatocyte differentiation 2/1096 15/18670 0.2189 0.3786 0.2568 PCK1/PCK2 2 BP GO:0071599 otic vesicle development 2/1096 15/18670 0.2189 0.3786 0.2568 SIX1/GATA3 2 BP GO:0072283 metanephric renal vesicle morphogenesis 2/1096 15/18670 0.2189 0.3786 0.2568 BMP4/STAT1 2 BP GO:0090136 epithelial cell-cell adhesion 2/1096 15/18670 0.2189 0.3786 0.2568 SERPINB8/THBS4 2 BP GO:0090141 positive regulation of mitochondrial fission 2/1096 15/18670 0.2189 0.3786 0.2568 PINK1/BNIP3 2 BP GO:0090177 establishment of planar polarity involved in neural tube closure 2/1096 15/18670 0.2189 0.3786 0.2568 FZD2/SFRP1 2 BP GO:0090192 regulation of glomerulus development 2/1096 15/18670 0.2189 0.3786 0.2568 ADIPOQ/BMP4 2 BP GO:0098840 protein transport along microtubule 2/1096 15/18670 0.2189 0.3786 0.2568 HSPB1/PURA 2 BP GO:0099118 microtubule-based protein transport 2/1096 15/18670 0.2189 0.3786 0.2568 HSPB1/PURA 2 BP GO:1900037 regulation of cellular response to hypoxia 2/1096 15/18670 0.2189 0.3786 0.2568 NOL3/PINK1 2 BP GO:1902188 positive regulation of viral release from host cell 2/1096 15/18670 0.2189 0.3786 0.2568 PC/VAPA 2 BP GO:1902260 negative regulation of delayed rectifier potassium channel activity 2/1096 15/18670 0.2189 0.3786 0.2568 ANK3/KCNAB1 2 BP GO:1903350 response to dopamine 2/1096 15/18670 0.2189 0.3786 0.2568 MAPK3/ID1 2 BP GO:0048813 dendrite morphogenesis 11/1096 143/18670 0.2191 0.3787 0.2569 SIPA1L1/SEMA3A/DCLK1/ZNF365/CUX1/SHANK2/NEDD4L/ID1/HPRT1/RERE/PDLIM5 11 BP GO:0044839 cell cycle G2/M phase transition 19/1096 266/18670 0.2194 0.3791 0.2571 PLCB1/MECP2/CDK14/DCTN3/CDC25B/CCND1/AKAP9/SMARCD3/CCNA2/CDK4/CCNB1/CETN2/TPX2/DCTN2/PLK1/FHL1/ATF5/CDC6/CCNB2 19 BP GO:0001541 ovarian follicle development 5/1096 55/18670 0.22 0.3791 0.2572 VEGFA/ICAM1/LFNG/FOXC1/INHBB 5 BP GO:0016233 telomere capping 5/1096 55/18670 0.22 0.3791 0.2572 MAPK3/MAP3K4/ERCC1/USP7/TFIP11 5 BP GO:0042304 regulation of fatty acid biosynthetic process 5/1096 55/18670 0.22 0.3791 0.2572 ADIPOQ/IL1B/ADIPOR2/RGN/APOC1 5 BP GO:0043551 regulation of phosphatidylinositol 3-kinase activity 5/1096 55/18670 0.22 0.3791 0.2572 PTK2B/CCR7/FGFR3/PDGFRA/FLT1 5 BP GO:0043954 cellular component maintenance 5/1096 55/18670 0.22 0.3791 0.2572 FCGR2B/INSR/F2R/APOE/CTTN 5 BP GO:0044273 sulfur compound catabolic process 5/1096 55/18670 0.22 0.3791 0.2572 CDO1/AHCY/HEXA/TST/HYAL1 5 BP GO:0048016 inositol phosphate-mediated signaling 5/1096 55/18670 0.22 0.3791 0.2572 DYRK2/HOMER3/MAPK7/CAMTA1/PPP3CC 5 BP GO:0061098 positive regulation of protein tyrosine kinase activity 5/1096 55/18670 0.22 0.3791 0.2572 CCL5/TGFA/ADORA1/PAK2/GAS6 5 BP GO:2000242 negative regulation of reproductive process 5/1096 55/18670 0.22 0.3791 0.2572 HPGDS/ADA/SULF1/ARHGDIB/BMP4 5 BP GO:0045017 glycerolipid biosynthetic process 18/1096 251/18670 0.2221 0.3827 0.2595 LPL/PCK1/PTPN13/PIP4K2B/CPNE1/SIK1/GK/RGN/PLSCR1/PLCG2/SH3YL1/GPAA1/INPP5F/PGAP2/ARF3/INPP5D/AGPAT1/PCK2 18 BP GO:1902803 regulation of synaptic vesicle transport 7/1096 84/18670 0.2227 0.3835 0.2601 STXBP1/PRKCB/PINK1/UNC13B/RIMS3/PFN2/ADCY1 7 BP GO:2001252 positive regulation of chromosome organization 13/1096 174/18670 0.2229 0.3838 0.2603 MECP2/VEGFA/GATA3/ATRX/IL1B/AUTS2/MAPK3/MAP3K4/PAF1/ERCC1/PINK1/CCNB1/JARID2 13 BP GO:0009065 glutamine family amino acid catabolic process 3/1096 28/18670 0.225 0.3861 0.2619 FAH/GOT2/GOT1 3 BP GO:0032647 regulation of interferon-alpha production 3/1096 28/18670 0.225 0.3861 0.2619 NMI/STAT1/IRF7 3 BP GO:0045408 regulation of interleukin-6 biosynthetic process 3/1096 28/18670 0.225 0.3861 0.2619 IL1B/PTAFR/INPP5D 3 BP GO:0045761 regulation of adenylate cyclase activity 3/1096 28/18670 0.225 0.3861 0.2619 TIMP2/CCR2/AKAP9 3 BP GO:0061615 glycolytic process through fructose-6-phosphate 3/1096 28/18670 0.225 0.3861 0.2619 PFKM/HK2/ALDOA 3 BP GO:0061620 glycolytic process through glucose-6-phosphate 3/1096 28/18670 0.225 0.3861 0.2619 PFKM/HK2/ALDOA 3 BP GO:0095500 acetylcholine receptor signaling pathway 3/1096 28/18670 0.225 0.3861 0.2619 PLCB1/GNA11/CHRM3 3 BP GO:1900543 negative regulation of purine nucleotide metabolic process 3/1096 28/18670 0.225 0.3861 0.2619 NUPR1/HDAC4/DDIT4 3 BP GO:1903792 negative regulation of anion transport 3/1096 28/18670 0.225 0.3861 0.2619 ADORA1/SFRP4/RGS2 3 BP GO:1903831 signal transduction involved in cellular response to ammonium ion 3/1096 28/18670 0.225 0.3861 0.2619 PLCB1/GNA11/CHRM3 3 BP GO:1990776 response to angiotensin 3/1096 28/18670 0.225 0.3861 0.2619 NFKB1/AGTR1/CDC6 3 BP GO:0043648 dicarboxylic acid metabolic process 8/1096 99/18670 0.2252 0.3864 0.2621 GRHPR/PCK1/ASS1/GOT2/ALDH5A1/ASPA/GOT1/MTHFD2 8 BP GO:0016579 protein deubiquitination 20/1096 283/18670 0.2258 0.3872 0.2626 TNFAIP3/GATA3/BIRC3/SMAD3/NFKBIA/USP11/SMAD1/AR/HIF1A/UCHL1/CCNA2/USP7/TADA3/USP46/EIF3F/RAD23B/NLRP3/TRAF3/USP5/IKBKG 20 BP GO:0032409 regulation of transporter activity 20/1096 283/18670 0.2258 0.3872 0.2626 P2RY6/ANK3/PTK2B/SHANK2/FXYD1/NEDD4L/PLN/RGN/PTAFR/CASQ2/KCNAB1/PLCG2/CCR2/CAV3/AKAP9/PINK1/ATP2A1/TWIST1/CCL2/FHL1 20 BP GO:0034754 cellular hormone metabolic process 10/1096 129/18670 0.2263 0.3878 0.2631 SPP1/ADH1B/AKR1B1/RBP4/ADH1A/ADH1C/PNPLA4/AKR1B10/DHRS3/PDGFRA 10 BP GO:0061515 myeloid cell development 6/1096 70/18670 0.2274 0.3894 0.2641 PTPN6/TSPAN2/JMJD6/NCKAP1L/TLR2/TRIM58 6 BP GO:0072091 regulation of stem cell proliferation 6/1096 70/18670 0.2274 0.3894 0.2641 VEGFA/PTPRC/CX3CR1/SMARCD3/HIF1A/PIM1 6 BP GO:2001259 positive regulation of cation channel activity 6/1096 70/18670 0.2274 0.3894 0.2641 P2RY6/ANK3/PLCG2/CCR2/PINK1/CCL2 6 BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 16/1096 221/18670 0.2275 0.3894 0.2641 GRK5/RGS1/S1PR1/ADCY9/ADORA1/PLN/GNA11/RGS2/PTHLH/ADCY6/PF4/CXCL10/PTGER2/S1PR4/CHRM3/ADCY1 16 BP GO:0022029 telencephalon cell migration 5/1096 56/18670 0.2309 0.3944 0.2675 CXCR4/EGFR/SEMA3A/CXCL12/NRP2 5 BP GO:0046148 pigment biosynthetic process 5/1096 56/18670 0.2309 0.3944 0.2675 ADA/HPRT1/NFE2L1/PPOX/UROD 5 BP GO:0048488 synaptic vesicle endocytosis 5/1096 56/18670 0.2309 0.3944 0.2675 DNM1/SYT17/SNAP91/KIAA1109/PPP3CC 5 BP GO:0072528 pyrimidine-containing compound biosynthetic process 5/1096 56/18670 0.2309 0.3944 0.2675 DCK/NME3/AGPAT1/TYMP/TK2 5 BP GO:0086002 cardiac muscle cell action potential involved in contraction 5/1096 56/18670 0.2309 0.3944 0.2675 BIN1/NEDD4L/KCNJ8/CAV3/SNTA1 5 BP GO:0090307 mitotic spindle assembly 5/1096 56/18670 0.2309 0.3944 0.2675 ARHGEF10/KIF3B/TPX2/PLK1/SPICE1 5 BP GO:0140238 presynaptic endocytosis 5/1096 56/18670 0.2309 0.3944 0.2675 DNM1/SYT17/SNAP91/KIAA1109/PPP3CC 5 BP GO:0021983 pituitary gland development 4/1096 42/18670 0.2314 0.3944 0.2675 PITX1/GATA2/BMP4/BMPR1A 4 BP GO:0033048 negative regulation of mitotic sister chromatid segregation 4/1096 42/18670 0.2314 0.3944 0.2675 ATRX/PTTG1/CCNB1/PLK1 4 BP GO:0044088 regulation of vacuole organization 4/1096 42/18670 0.2314 0.3944 0.2675 PIP4K2B/NUPR1/PINK1/NPRL3 4 BP GO:0099622 cardiac muscle cell membrane repolarization 4/1096 42/18670 0.2314 0.3944 0.2675 KCNJ8/CAV3/AKAP9/SNTA1 4 BP GO:0002028 regulation of sodium ion transport 7/1096 85/18670 0.2314 0.3944 0.2675 SERPINE2/ANK3/FXYD1/NEDD4L/SIK1/CAV3/SNTA1 7 BP GO:0045682 regulation of epidermis development 7/1096 85/18670 0.2314 0.3944 0.2675 TGFB2/SFRP4/CTSL/BMP4/PRKCH/MAFF/FOXC1 7 BP GO:1904705 regulation of vascular smooth muscle cell proliferation 7/1096 85/18670 0.2314 0.3944 0.2675 P2RY6/ADIPOQ/PAK1/IGFBP5/PRKG1/BMPR1A/JUN 7 BP GO:1990874 vascular smooth muscle cell proliferation 7/1096 85/18670 0.2314 0.3944 0.2675 P2RY6/ADIPOQ/PAK1/IGFBP5/PRKG1/BMPR1A/JUN 7 BP GO:0000077 DNA damage checkpoint 11/1096 145/18670 0.2322 0.3954 0.2682 MDC1/TP53BP1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1/CUL4A 11 BP GO:0006865 amino acid transport 11/1096 145/18670 0.2322 0.3954 0.2682 NFKBIE/STXBP1/ADORA1/SLC1A4/PRAF2/RGS2/PDPN/SLC7A8/SLC7A5/UNC13B/NFE2L1 11 BP GO:0007612 learning 11/1096 145/18670 0.2322 0.3954 0.2682 MECP2/SHANK2/BTG2/INSR/B4GALT2/HIF1A/NRGN/TLR2/LGMN/NPTX2/JUN 11 BP GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 8/1096 100/18670 0.2332 0.3968 0.2691 P2RY6/S1PR1/TGM2/GNA11/CX3CR1/F2R/AGTR1/C3AR1 8 BP GO:0030301 cholesterol transport 8/1096 100/18670 0.2332 0.3968 0.2691 ADIPOQ/NFKBIA/NFKB1/LIPC/NPC1/ABCG1/APOC1/APOE 8 BP GO:0070498 interleukin-1-mediated signaling pathway 8/1096 100/18670 0.2332 0.3968 0.2691 PLCB1/IL1RN/IL1B/MAPK3/NFKBIA/NFKB1/MYD88/IKBKG 8 BP GO:0042157 lipoprotein metabolic process 10/1096 130/18670 0.2333 0.3968 0.2691 ITGAV/UGCG/CTSD/APOC1/GPAA1/PGAP2/APOE/WDR45/PPM1A/LYPLA1 10 BP GO:0090150 establishment of protein localization to membrane 23/1096 332/18670 0.2339 0.3977 0.2698 GZMB/EGFR/ANK3/CLSTN1/RFTN1/PAK1/ADORA1/SPTBN1/HSPA5/NPC1/PEX19/RPS5/TRAM2/RPL18/BAD/MAPK10/SEC63/RPLP0/CSK/ITGB2/RPL13/PPP3CC/LYPLA1 23 BP GO:1901990 regulation of mitotic cell cycle phase transition 30/1096 444/18670 0.2368 0.4024 0.2729 PLCB1/MECP2/EGFR/CDK10/DCTN3/BTG2/CCND2/CDC25B/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/PLK2/AKAP9/SMARCD3/CDK4/CCNB1/CETN2/TPX2/CNOT4/CARM1/DCTN2/TFAP4/PLK1/CCL2/FHL1/CUL4A/HYAL1/CDC6 30 BP GO:0042440 pigment metabolic process 6/1096 71/18670 0.2372 0.4024 0.2729 ADA/BLVRA/HPRT1/NFE2L1/PPOX/UROD 6 BP GO:0006140 regulation of nucleotide metabolic process 11/1096 146/18670 0.2389 0.4024 0.2729 ZBTB20/NUPR1/PDK2/COX7A1/INSR/HIF1A/PINK1/CCNB1/HDAC4/DDIT4/NUP210 11 BP GO:0035264 multicellular organism growth 11/1096 146/18670 0.2389 0.4024 0.2729 FTO/WWTR1/ATRX/AR/ERCC1/HOXA5/CDK4/DIO3/LGMN/STIL/ATF5 11 BP GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 7/1096 86/18670 0.2402 0.4024 0.2729 ATP9A/KIF3B/TMED3/KDELR3/KDELR1/ARF3/TAPBP 7 BP GO:0090559 regulation of membrane permeability 7/1096 86/18670 0.2402 0.4024 0.2729 GZMB/HK2/NOL3/ZNF205/BAD/BNIP3/PPP3CC 7 BP GO:0018205 peptidyl-lysine modification 27/1096 397/18670 0.2402 0.4024 0.2729 EZH1/EGR2/MECP2/LOXL2/KAT6B/GATA3/PCGF2/ATRX/IL1B/AUTS2/MAPK3/TGM2/BRD8/GATA2/JMJD6/ZMIZ1/EHMT2/TADA3/MSL3/HDAC4/KAT5/JARID2/TWIST1/NUP210/LOXL1/JADE2/NNAT 27 BP GO:0000132 establishment of mitotic spindle orientation 3/1096 29/18670 0.2408 0.4024 0.2729 GPSM2/PLK1/SPRY1 3 BP GO:0005979 regulation of glycogen biosynthetic process 3/1096 29/18670 0.2408 0.4024 0.2729 ENPP1/INSR/DYRK2 3 BP GO:0006294 nucleotide-excision repair, preincision complex assembly 3/1096 29/18670 0.2408 0.4024 0.2729 CETN2/RAD23B/CUL4A 3 BP GO:0007263 nitric oxide mediated signal transduction 3/1096 29/18670 0.2408 0.4024 0.2729 VEGFA/EGFR/APOE 3 BP GO:0007271 synaptic transmission, cholinergic 3/1096 29/18670 0.2408 0.4024 0.2729 NQO1/APOE/CHRM3 3 BP GO:0010390 histone monoubiquitination 3/1096 29/18670 0.2408 0.4024 0.2729 PCGF2/PAF1/RING1 3 BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/1096 29/18670 0.2408 0.4024 0.2729 PLN/CASQ2/HDAC4 3 BP GO:0010962 regulation of glucan biosynthetic process 3/1096 29/18670 0.2408 0.4024 0.2729 ENPP1/INSR/DYRK2 3 BP GO:0015949 nucleobase-containing small molecule interconversion 3/1096 29/18670 0.2408 0.4024 0.2729 AK1/NME3/GUK1 3 BP GO:0021884 forebrain neuron development 3/1096 29/18670 0.2408 0.4024 0.2729 SEMA3A/NRP2/ATF5 3 BP GO:0033014 tetrapyrrole biosynthetic process 3/1096 29/18670 0.2408 0.4024 0.2729 NFE2L1/PPOX/UROD 3 BP GO:0042219 cellular modified amino acid catabolic process 3/1096 29/18670 0.2408 0.4024 0.2729 GOT2/DIO3/AHCY 3 BP GO:0042226 interleukin-6 biosynthetic process 3/1096 29/18670 0.2408 0.4024 0.2729 IL1B/PTAFR/INPP5D 3 BP GO:0045822 negative regulation of heart contraction 3/1096 29/18670 0.2408 0.4024 0.2729 BIN1/ADORA1/PLN 3 BP GO:0045980 negative regulation of nucleotide metabolic process 3/1096 29/18670 0.2408 0.4024 0.2729 NUPR1/HDAC4/DDIT4 3 BP GO:0050974 detection of mechanical stimulus involved in sensory perception 3/1096 29/18670 0.2408 0.4024 0.2729 SERPINE2/CXCR4/CXCL12 3 BP GO:0051642 centrosome localization 3/1096 29/18670 0.2408 0.4024 0.2729 GPSM2/AKAP9/PLXNA2 3 BP GO:0060765 regulation of androgen receptor signaling pathway 3/1096 29/18670 0.2408 0.4024 0.2729 HDAC1/PHB/SFRP1 3 BP GO:0061099 negative regulation of protein tyrosine kinase activity 3/1096 29/18670 0.2408 0.4024 0.2729 PTPRC/THY1/PTPN2 3 BP GO:0070528 protein kinase C signaling 3/1096 29/18670 0.2408 0.4024 0.2729 VEGFA/CD40/PLEK 3 BP GO:0072538 T-helper 17 type immune response 3/1096 29/18670 0.2408 0.4024 0.2729 IL27RA/BATF/NLRP3 3 BP GO:2000171 negative regulation of dendrite development 3/1096 29/18670 0.2408 0.4024 0.2729 ID1/PLK2/CARM1 3 BP GO:0019083 viral transcription 13/1096 177/18670 0.241 0.4024 0.2729 CCL5/MID2/RPS5/RPL18/POLR2E/HDAC1/RPLP0/POLR2I/TFAP4/NUP210/RPL13/JUN/SUPT5H 13 BP GO:0001780 neutrophil homeostasis 2/1096 16/18670 0.2411 0.4024 0.2729 AXL/CCR2 2 BP GO:0001946 lymphangiogenesis 2/1096 16/18670 0.2411 0.4024 0.2729 PDPN/FOXC1 2 BP GO:0006103 2-oxoglutarate metabolic process 2/1096 16/18670 0.2411 0.4024 0.2729 GOT2/GOT1 2 BP GO:0006206 pyrimidine nucleobase metabolic process 2/1096 16/18670 0.2411 0.4024 0.2729 ALDH6A1/TYMP 2 BP GO:0010885 regulation of cholesterol storage 2/1096 16/18670 0.2411 0.4024 0.2729 LPL/ABCG1 2 BP GO:0010934 macrophage cytokine production 2/1096 16/18670 0.2411 0.4024 0.2729 TGFB2/GAS6 2 BP GO:0014048 regulation of glutamate secretion 2/1096 16/18670 0.2411 0.4024 0.2729 STXBP1/ADORA1 2 BP GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 2/1096 16/18670 0.2411 0.4024 0.2729 SERPINE2/TWIST1 2 BP GO:0030889 negative regulation of B cell proliferation 2/1096 16/18670 0.2411 0.4024 0.2729 FCGR2B/INPP5D 2 BP GO:0031958 corticosteroid receptor signaling pathway 2/1096 16/18670 0.2411 0.4024 0.2729 PHB/LMO3 2 BP GO:0032354 response to follicle-stimulating hormone 2/1096 16/18670 0.2411 0.4024 0.2729 TGFBR3/EFNA5 2 BP GO:0032695 negative regulation of interleukin-12 production 2/1096 16/18670 0.2411 0.4024 0.2729 SLAMF1/NFKB1 2 BP GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 2/1096 16/18670 0.2411 0.4024 0.2729 GMFG/NCKAP1 2 BP GO:0035970 peptidyl-threonine dephosphorylation 2/1096 16/18670 0.2411 0.4024 0.2729 DUSP5/PPM1A 2 BP GO:0036124 histone H3-K9 trimethylation 2/1096 16/18670 0.2411 0.4024 0.2729 MECP2/ATRX 2 BP GO:0042033 chemokine biosynthetic process 2/1096 16/18670 0.2411 0.4024 0.2729 IL1B/ELANE 2 BP GO:0042447 hormone catabolic process 2/1096 16/18670 0.2411 0.4024 0.2729 SPP1/DIO3 2 BP GO:0043217 myelin maintenance 2/1096 16/18670 0.2411 0.4024 0.2729 CXCR4/NDRG1 2 BP GO:0045618 positive regulation of keratinocyte differentiation 2/1096 16/18670 0.2411 0.4024 0.2729 PRKCH/FOXC1 2 BP GO:0045722 positive regulation of gluconeogenesis 2/1096 16/18670 0.2411 0.4024 0.2729 FOXO1/PTPN2 2 BP GO:0045989 positive regulation of striated muscle contraction 2/1096 16/18670 0.2411 0.4024 0.2729 RGS2/ATP2A1 2 BP GO:0048012 hepatocyte growth factor receptor signaling pathway 2/1096 16/18670 0.2411 0.4024 0.2729 PAK1/PTPN2 2 BP GO:0048385 regulation of retinoic acid receptor signaling pathway 2/1096 16/18670 0.2411 0.4024 0.2729 CNOT1/DHRS3 2 BP GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 2/1096 16/18670 0.2411 0.4024 0.2729 SYT17/RIMS3 2 BP GO:0050755 chemokine metabolic process 2/1096 16/18670 0.2411 0.4024 0.2729 IL1B/ELANE 2 BP GO:0055119 relaxation of cardiac muscle 2/1096 16/18670 0.2411 0.4024 0.2729 PLN/RGS2 2 BP GO:0072109 glomerular mesangium development 2/1096 16/18670 0.2411 0.4024 0.2729 ACTA2/BMP4 2 BP GO:0072176 nephric duct development 2/1096 16/18670 0.2411 0.4024 0.2729 GATA3/BMP4 2 BP GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 2/1096 16/18670 0.2411 0.4024 0.2729 PLN/RGS2 2 BP GO:0090036 regulation of protein kinase C signaling 2/1096 16/18670 0.2411 0.4024 0.2729 VEGFA/CD40 2 BP GO:0099170 postsynaptic modulation of chemical synaptic transmission 2/1096 16/18670 0.2411 0.4024 0.2729 PLCB1/NRGN 2 BP GO:1900242 regulation of synaptic vesicle endocytosis 2/1096 16/18670 0.2411 0.4024 0.2729 DNM1/PPP3CC 2 BP GO:1905153 regulation of membrane invagination 2/1096 16/18670 0.2411 0.4024 0.2729 GATA2/NCKAP1L 2 BP GO:0006661 phosphatidylinositol biosynthetic process 9/1096 116/18670 0.2413 0.4026 0.273 PTPN13/PIP4K2B/PLCG2/SH3YL1/GPAA1/INPP5F/PGAP2/ARF3/INPP5D 9 BP GO:0000018 regulation of DNA recombination 8/1096 101/18670 0.2414 0.4026 0.2731 IL7R/ZNF365/CD40/TP53BP1/IL27RA/PTPRC/PARP3/TFRC 8 BP GO:0002066 columnar/cuboidal epithelial cell development 5/1096 57/18670 0.2419 0.4031 0.2734 FGFR1/HOXA5/HIF1A/BMP4/BAD 5 BP GO:0019320 hexose catabolic process 5/1096 57/18670 0.2419 0.4031 0.2734 PFKM/HK2/LRP5/BAD/ALDOA 5 BP GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 5/1096 57/18670 0.2419 0.4031 0.2734 OXCT1/HIF1A/EFNA5/LRP5/BAD 5 BP GO:0050657 nucleic acid transport 14/1096 193/18670 0.2442 0.4058 0.2752 RFTN1/DDX39A/UPF3A/PURA/SLBP/MX2/CETN2/IGF2BP3/CDC40/TST/CASC3/NXF1/NUP210/POLDIP3 14 BP GO:0050658 RNA transport 14/1096 193/18670 0.2442 0.4058 0.2752 RFTN1/DDX39A/UPF3A/PURA/SLBP/MX2/CETN2/IGF2BP3/CDC40/TST/CASC3/NXF1/NUP210/POLDIP3 14 BP GO:0000096 sulfur amino acid metabolic process 4/1096 43/18670 0.2443 0.4058 0.2752 CDO1/AHCY/TST/AHCYL2 4 BP GO:0001953 negative regulation of cell-matrix adhesion 4/1096 43/18670 0.2443 0.4058 0.2752 SEMA3E/POSTN/DLC1/SERPINE1 4 BP GO:0006692 prostanoid metabolic process 4/1096 43/18670 0.2443 0.4058 0.2752 PTGS1/HPGDS/IL1B/PTGDS 4 BP GO:0006693 prostaglandin metabolic process 4/1096 43/18670 0.2443 0.4058 0.2752 PTGS1/HPGDS/IL1B/PTGDS 4 BP GO:0006775 fat-soluble vitamin metabolic process 4/1096 43/18670 0.2443 0.4058 0.2752 IL1B/NFKB1/FGFR1/LGMN 4 BP GO:0006904 vesicle docking involved in exocytosis 4/1096 43/18670 0.2443 0.4058 0.2752 STXBP1/PLEK/STXBP2/UNC13B 4 BP GO:0031279 regulation of cyclase activity 4/1096 43/18670 0.2443 0.4058 0.2752 MAPK3/TIMP2/CCR2/AKAP9 4 BP GO:0045746 negative regulation of Notch signaling pathway 4/1096 43/18670 0.2443 0.4058 0.2752 EGFR/NFKBIA/GATA2/LFNG 4 BP GO:0051293 establishment of spindle localization 4/1096 43/18670 0.2443 0.4058 0.2752 GPSM2/MAP4/PLK1/SPRY1 4 BP GO:0006644 phospholipid metabolic process 29/1096 430/18670 0.2445 0.406 0.2754 PLCB1/LPL/MECP2/PTPN13/PIP4K2B/PTK2B/CPNE1/PLEK/GPX4/CCR7/PNPLA6/LIPC/PLSCR1/PLCG2/SH3YL1/APOC1/GPAA1/INPP5F/ALDH5A1/PGAP2/PLA2G7/PMVK/ARF3/INPP5D/AGPAT1/FGFR3/PDGFRA/PLA2G15/FLT1 29 BP GO:0019359 nicotinamide nucleotide biosynthetic process 11/1096 147/18670 0.2457 0.4075 0.2764 ZBTB20/NUPR1/NAMPT/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/NUP210/ALDOA 11 BP GO:0019363 pyridine nucleotide biosynthetic process 11/1096 147/18670 0.2457 0.4075 0.2764 ZBTB20/NUPR1/NAMPT/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/NUP210/ALDOA 11 BP GO:0070972 protein localization to endoplasmic reticulum 11/1096 147/18670 0.2457 0.4075 0.2764 HSPA5/RPS5/TRAM2/GPAA1/RPL18/KDELR3/KDELR1/SEC63/RPLP0/RPL13/VAPA 11 BP GO:0090263 positive regulation of canonical Wnt signaling pathway 11/1096 147/18670 0.2457 0.4075 0.2764 SEMA5A/EGFR/SMAD3/SFRP4/NFKB1/COL1A1/KANK1/PIN1/GPC5/SFRP1/PPM1A 11 BP GO:0051155 positive regulation of striated muscle cell differentiation 6/1096 72/18670 0.247 0.4095 0.2777 IL4R/CD53/CAV3/PIN1/BMP4/TNFSF14 6 BP GO:1903747 regulation of establishment of protein localization to mitochondrion 6/1096 72/18670 0.247 0.4095 0.2777 RAC2/HUWE1/GZMB/PINK1/BAD/PPP3CC 6 BP GO:0022406 membrane docking 13/1096 178/18670 0.2471 0.4095 0.2777 STXBP1/STX11/ICAM1/DCTN3/PLEK/ESYT1/STXBP2/AKAP9/UNC13B/B9D1/CETN2/DCTN2/PLK1 13 BP GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 18/1096 256/18670 0.2472 0.4095 0.2777 GRK5/RGS1/S1PR1/ADCY9/ADORA1/PLN/GNA11/RGS2/PTHLH/VIPR1/ADCY6/PF4/CXCL10/PTGER2/CCL2/S1PR4/CHRM3/ADCY1 18 BP GO:0022904 respiratory electron transport chain 9/1096 117/18670 0.2489 0.4122 0.2796 MECP2/ALDH5A1/PINK1/CCNB1/COX6A2/NDUFB7/NDUFV1/UQCRC1/ETFB 9 BP GO:1900371 regulation of purine nucleotide biosynthetic process 9/1096 117/18670 0.2489 0.4122 0.2796 ZBTB20/NUPR1/PDK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NUP210 9 BP GO:0006900 vesicle budding from membrane 8/1096 102/18670 0.2496 0.4132 0.2803 TGFA/FNBP1L/SERPINA1/CTSC/DNM1/F8/SNAP91/VAPA 8 BP GO:0015931 nucleobase-containing compound transport 17/1096 241/18670 0.2508 0.4151 0.2815 RFTN1/ADORA1/SLC29A1/DDX39A/UPF3A/PURA/SLBP/MX2/CETN2/SLC25A4/IGF2BP3/CDC40/TST/CASC3/NXF1/NUP210/POLDIP3 17 BP GO:1901987 regulation of cell cycle phase transition 32/1096 480/18670 0.2517 0.4163 0.2824 PLCB1/MECP2/EGFR/CDK10/DCTN3/BTG2/CCND2/CDC25B/PTPN6/CCND1/CNOT1/CDKN2C/NACC2/PLK2/PAF1/AKAP9/SMARCD3/CDK4/CCNB1/CETN2/TPX2/CNOT4/CARM1/DCTN2/TFAP4/PLK1/CCL2/FHL1/CUL4A/HYAL1/ATF5/CDC6 32 BP GO:0030178 negative regulation of Wnt signaling pathway 15/1096 210/18670 0.2526 0.4177 0.2833 FOXO1/WIF1/WWTR1/TCF7L2/SFRP4/IGFBP6/RAPGEF1/IGFBP2/HDAC1/APOE/CTNNBIP1/G3BP1/CDH2/SFRP1/CBY1 15 BP GO:0098930 axonal transport 5/1096 58/18670 0.2531 0.4184 0.2838 KIF3B/HSPB1/DST/HIF1A/UCHL1 5 BP GO:0006479 protein methylation 13/1096 179/18670 0.2533 0.4185 0.2838 EZH1/MECP2/GATA3/ATRX/AUTS2/BTG2/PAF1/EHMT2/FBL/GSPT1/SATB1/JARID2/CARM1 13 BP GO:0008213 protein alkylation 13/1096 179/18670 0.2533 0.4185 0.2838 EZH1/MECP2/GATA3/ATRX/AUTS2/BTG2/PAF1/EHMT2/FBL/GSPT1/SATB1/JARID2/CARM1 13 BP GO:0051099 positive regulation of binding 13/1096 179/18670 0.2533 0.4185 0.2838 GATA3/TCF7L2/MAPRE3/PLK2/PIN1/BMP4/PLAUR/LFNG/APOE/NGF/TWIST1/FOXC1/MBD2 13 BP GO:0030808 regulation of nucleotide biosynthetic process 9/1096 118/18670 0.2567 0.4217 0.286 ZBTB20/NUPR1/PDK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NUP210 9 BP GO:0000002 mitochondrial genome maintenance 3/1096 30/18670 0.2569 0.4217 0.286 AKT3/SLC25A4/TYMP 3 BP GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/1096 30/18670 0.2569 0.4217 0.286 GZMB/BAD/PPP3CC 3 BP GO:0007274 neuromuscular synaptic transmission 3/1096 30/18670 0.2569 0.4217 0.286 STXBP1/EGR3/RIMBP2 3 BP GO:0032607 interferon-alpha production 3/1096 30/18670 0.2569 0.4217 0.286 NMI/STAT1/IRF7 3 BP GO:0042759 long-chain fatty acid biosynthetic process 3/1096 30/18670 0.2569 0.4217 0.286 LTC4S/GPX4/ALOX5 3 BP GO:0046640 regulation of alpha-beta T cell proliferation 3/1096 30/18670 0.2569 0.4217 0.286 IRF1/PTPRC/CCR2 3 BP GO:0048384 retinoic acid receptor signaling pathway 3/1096 30/18670 0.2569 0.4217 0.286 CNOT1/DHRS3/RXRA 3 BP GO:0061037 negative regulation of cartilage development 3/1096 30/18670 0.2569 0.4217 0.286 PTHLH/BMP4/EFEMP1 3 BP GO:0061842 microtubule organizing center localization 3/1096 30/18670 0.2569 0.4217 0.286 GPSM2/AKAP9/PLXNA2 3 BP GO:0090314 positive regulation of protein targeting to membrane 3/1096 30/18670 0.2569 0.4217 0.286 ANK3/PAK1/ITGB2 3 BP GO:0097421 liver regeneration 3/1096 30/18670 0.2569 0.4217 0.286 EGFR/RGN/CCND1 3 BP GO:1905144 response to acetylcholine 3/1096 30/18670 0.2569 0.4217 0.286 PLCB1/GNA11/CHRM3 3 BP GO:1905145 cellular response to acetylcholine 3/1096 30/18670 0.2569 0.4217 0.286 PLCB1/GNA11/CHRM3 3 BP GO:1905476 negative regulation of protein localization to membrane 3/1096 30/18670 0.2569 0.4217 0.286 GBP1/CSK/LYPLA1 3 BP GO:0043627 response to estrogen 6/1096 73/18670 0.257 0.4217 0.286 IL4R/GATA3/CCND1/IGFBP2/SFRP1/SMAD6 6 BP GO:0003197 endocardial cushion development 4/1096 44/18670 0.2573 0.4217 0.286 TGFB2/BMP4/BMPR1A/TWIST1 4 BP GO:0003416 endochondral bone growth 4/1096 44/18670 0.2573 0.4217 0.286 DDR2/STC1/CARM1/FGFR3 4 BP GO:0006378 mRNA polyadenylation 4/1096 44/18670 0.2573 0.4217 0.286 SNRPA/PAF1/SCAF8/SUPT5H 4 BP GO:0014002 astrocyte development 4/1096 44/18670 0.2573 0.4217 0.286 EGFR/IL1B/TSPAN2/LAMB2 4 BP GO:0014003 oligodendrocyte development 4/1096 44/18670 0.2573 0.4217 0.286 GSN/ASPA/ID4/TLR2 4 BP GO:0033046 negative regulation of sister chromatid segregation 4/1096 44/18670 0.2573 0.4217 0.286 ATRX/PTTG1/CCNB1/PLK1 4 BP GO:0042987 amyloid precursor protein catabolic process 4/1096 44/18670 0.2573 0.4217 0.286 BIN1/ABCG1/PIN1/APOE 4 BP GO:0044331 cell-cell adhesion mediated by cadherin 4/1096 44/18670 0.2573 0.4217 0.286 ADAM19/VEGFA/CDH5/CDH2 4 BP GO:0060412 ventricular septum morphogenesis 4/1096 44/18670 0.2573 0.4217 0.286 TGFBR3/TGFB2/FZD2/BMP4 4 BP GO:0070266 necroptotic process 4/1096 44/18670 0.2573 0.4217 0.286 BIRC3/LY96/CD14/SLC25A4 4 BP GO:0090311 regulation of protein deacetylation 4/1096 44/18670 0.2573 0.4217 0.286 VEGFA/PINK1/ZNHIT1/TADA3 4 BP GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4/1096 44/18670 0.2573 0.4217 0.286 GZMB/ZNF205/BAD/PPP3CC 4 BP GO:0006767 water-soluble vitamin metabolic process 7/1096 88/18670 0.2582 0.4229 0.2868 SLC2A3/ENPP1/RGN/SLC23A2/CYB5R3/PC/MTHFD2 7 BP GO:0043470 regulation of carbohydrate catabolic process 7/1096 88/18670 0.2582 0.4229 0.2868 ZBTB20/NUPR1/INSR/HIF1A/HDAC4/DDIT4/NUP210 7 BP GO:0048592 eye morphogenesis 11/1096 149/18670 0.2594 0.4247 0.288 VEGFA/CDON/RBP4/HIF1A/THY1/BMP4/DIO3/LRP5/EFEMP1/TWIST1/RING1 11 BP GO:0006694 steroid biosynthetic process 14/1096 196/18670 0.2621 0.4264 0.2892 CH25H/IL1B/AKR1B1/CYB5R1/IGFBP7/CYB5R3/NFKB1/ABCG1/SLC27A2/ACOX2/LBR/PMVK/HSD11B2/APOE 14 BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 14/1096 196/18670 0.2621 0.4264 0.2892 MECP2/DCTN3/CDC25B/CCND1/AKAP9/SMARCD3/CDK4/CCNB1/CETN2/TPX2/DCTN2/PLK1/FHL1/CDC6 14 BP GO:0051236 establishment of RNA localization 14/1096 196/18670 0.2621 0.4264 0.2892 RFTN1/DDX39A/UPF3A/PURA/SLBP/MX2/CETN2/IGF2BP3/CDC40/TST/CASC3/NXF1/NUP210/POLDIP3 14 BP GO:0002418 immune response to tumor cell 2/1096 17/18670 0.2633 0.4264 0.2892 CD226/CRTAM 2 BP GO:0006266 DNA ligation 2/1096 17/18670 0.2633 0.4264 0.2892 PARP3/TFIP11 2 BP GO:0006590 thyroid hormone generation 2/1096 17/18670 0.2633 0.4264 0.2892 GATA3/DIO3 2 BP GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2/1096 17/18670 0.2633 0.4264 0.2892 KAT5/TFAP4 2 BP GO:0007379 segment specification 2/1096 17/18670 0.2633 0.4264 0.2892 MEOX1/COBL 2 BP GO:0010224 response to UV-B 2/1096 17/18670 0.2633 0.4264 0.2892 MFAP4/HYAL1 2 BP GO:0010715 regulation of extracellular matrix disassembly 2/1096 17/18670 0.2633 0.4264 0.2892 DDR2/PDPN 2 BP GO:0016584 nucleosome positioning 2/1096 17/18670 0.2633 0.4264 0.2892 SMARCA1/PAF1 2 BP GO:0032740 positive regulation of interleukin-17 production 2/1096 17/18670 0.2633 0.4264 0.2892 MYD88/IL15 2 BP GO:0032780 negative regulation of ATPase activity 2/1096 17/18670 0.2633 0.4264 0.2892 PLN/RGN 2 BP GO:0033262 regulation of nuclear cell cycle DNA replication 2/1096 17/18670 0.2633 0.4264 0.2892 ATRX/FGFR1 2 BP GO:0034384 high-density lipoprotein particle clearance 2/1096 17/18670 0.2633 0.4264 0.2892 HDLBP/APOE 2 BP GO:0035313 wound healing, spreading of epidermal cells 2/1096 17/18670 0.2633 0.4264 0.2892 HBEGF/ITGA5 2 BP GO:0035518 histone H2A monoubiquitination 2/1096 17/18670 0.2633 0.4264 0.2892 PCGF2/RING1 2 BP GO:0042249 establishment of planar polarity of embryonic epithelium 2/1096 17/18670 0.2633 0.4264 0.2892 FZD2/SFRP1 2 BP GO:0042268 regulation of cytolysis 2/1096 17/18670 0.2633 0.4264 0.2892 PF4/LBP 2 BP GO:0042994 cytoplasmic sequestering of transcription factor 2/1096 17/18670 0.2633 0.4264 0.2892 NFKBIE/NFKBIA 2 BP GO:0043923 positive regulation by host of viral transcription 2/1096 17/18670 0.2633 0.4264 0.2892 TFAP4/JUN 2 BP GO:0043968 histone H2A acetylation 2/1096 17/18670 0.2633 0.4264 0.2892 BRD8/MSL3 2 BP GO:0045721 negative regulation of gluconeogenesis 2/1096 17/18670 0.2633 0.4264 0.2892 ADIPOQ/SIK1 2 BP GO:0045725 positive regulation of glycogen biosynthetic process 2/1096 17/18670 0.2633 0.4264 0.2892 INSR/DYRK2 2 BP GO:0046068 cGMP metabolic process 2/1096 17/18670 0.2633 0.4264 0.2892 PDE1A/PDE9A 2 BP GO:0046500 S-adenosylmethionine metabolic process 2/1096 17/18670 0.2633 0.4264 0.2892 AHCY/AHCYL2 2 BP GO:0048521 negative regulation of behavior 2/1096 17/18670 0.2633 0.4264 0.2892 ADA/ADORA1 2 BP GO:0051709 regulation of killing of cells of other organism 2/1096 17/18670 0.2633 0.4264 0.2892 CXCL6/BAD 2 BP GO:0060046 regulation of acrosome reaction 2/1096 17/18670 0.2633 0.4264 0.2892 PLCB1/STXBP1 2 BP GO:0060644 mammary gland epithelial cell differentiation 2/1096 17/18670 0.2633 0.4264 0.2892 HOXA5/HIF1A 2 BP GO:0097107 postsynaptic density assembly 2/1096 17/18670 0.2633 0.4264 0.2892 NTRK3/SHANK2 2 BP GO:0097501 stress response to metal ion 2/1096 17/18670 0.2633 0.4264 0.2892 HSPA5/MT1G 2 BP GO:0098884 postsynaptic neurotransmitter receptor internalization 2/1096 17/18670 0.2633 0.4264 0.2892 DNM1/USP46 2 BP GO:0099010 modification of postsynaptic structure 2/1096 17/18670 0.2633 0.4264 0.2892 MYH10/PFN2 2 BP GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 2/1096 17/18670 0.2633 0.4264 0.2892 CALB2/ADORA1 2 BP GO:0140239 postsynaptic endocytosis 2/1096 17/18670 0.2633 0.4264 0.2892 DNM1/USP46 2 BP GO:1900363 regulation of mRNA polyadenylation 2/1096 17/18670 0.2633 0.4264 0.2892 SNRPA/SUPT5H 2 BP GO:1901317 regulation of flagellated sperm motility 2/1096 17/18670 0.2633 0.4264 0.2892 RGN/CCR6 2 BP GO:1904355 positive regulation of telomere capping 2/1096 17/18670 0.2633 0.4264 0.2892 MAPK3/MAP3K4 2 BP GO:0043388 positive regulation of DNA binding 5/1096 59/18670 0.2643 0.4276 0.29 GATA3/PLAUR/NGF/TWIST1/FOXC1 5 BP GO:0045071 negative regulation of viral genome replication 5/1096 59/18670 0.2643 0.4276 0.29 CCL5/SLPI/PLSCR1/ISG20/VAPA 5 BP GO:0046847 filopodium assembly 5/1096 59/18670 0.2643 0.4276 0.29 FNBP1L/CCR7/RALA/TENM1/GAP43 5 BP GO:0032392 DNA geometric change 9/1096 119/18670 0.2645 0.4278 0.2901 HMGA1/CHD9/ATRX/SMARCA1/PURA/CETN2/G3BP1/RAD23B/CUL4A 9 BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28/1096 419/18670 0.2648 0.428 0.2903 TRIM2/WWTR1/NEDD4L/RNF144A/HSPA5/TRIB2/PTTG1/PLK2/TNFAIP1/RNF103/UCHL1/FBXO9/CCNB1/PCBP2/UBE4B/CAMLG/UBE2J1/USP7/AREL1/KAT5/RAD23B/PLK1/WFS1/CUL4A/USP5/FBXL14/HERPUD1/GLMN 28 BP GO:0006732 coenzyme metabolic process 27/1096 403/18670 0.265 0.4284 0.2906 ZBTB20/SLC2A3/NUPR1/NAMPT/PFKM/HK2/GCH1/RGN/SLC23A2/CYB5R3/TECR/CD38/PDK2/INSR/PC/HIF1A/PCBD1/AHCY/PMVK/PGD/QDPR/HDAC4/DDIT4/MTHFD2/NUP210/ALDOA/AHCYL2 27 BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 11/1096 150/18670 0.2663 0.4301 0.2917 TRBC1/FCGR2B/PTPN6/PTPRC/IGKC/CFI/IGLV6-57/C6/APCS/IGLC1/C7 11 BP GO:0031123 RNA 3'-end processing 11/1096 150/18670 0.2663 0.4301 0.2917 SNRPA/DDX39A/PAF1/CCNB1/SLBP/FBL/SCAF8/CDC40/CASC3/POLDIP3/SUPT5H 11 BP GO:0072525 pyridine-containing compound biosynthetic process 11/1096 150/18670 0.2663 0.4301 0.2917 ZBTB20/NUPR1/NAMPT/PFKM/HK2/INSR/HIF1A/HDAC4/DDIT4/NUP210/ALDOA 11 BP GO:0006081 cellular aldehyde metabolic process 6/1096 74/18670 0.267 0.431 0.2923 GRHPR/GOT2/ALDH3B1/AKR7A2/PGD/ALDH3A2 6 BP GO:0060998 regulation of dendritic spine development 6/1096 74/18670 0.267 0.431 0.2923 SIPA1L1/SHANK2/DLG5/PLK2/APOE/PDLIM5 6 BP GO:0032410 negative regulation of transporter activity 7/1096 89/18670 0.2674 0.4313 0.2925 ANK3/NEDD4L/PLN/CASQ2/KCNAB1/CAV3/TWIST1 7 BP GO:1901019 regulation of calcium ion transmembrane transporter activity 7/1096 89/18670 0.2674 0.4313 0.2925 P2RY6/PLN/RGN/CASQ2/PLCG2/CAV3/ATP2A1 7 BP GO:0072659 protein localization to plasma membrane 18/1096 260/18670 0.268 0.4322 0.2931 TSPAN5/STXBP1/EPHA3/EGFR/ADIPOQ/ANK3/EMP2/SPTBN1/AR/GAS6/SKAP1/CAV3/GBP1/KCNB2/PRKCH/CSK/CDH2/LYPLA1 18 BP GO:0043484 regulation of RNA splicing 10/1096 135/18670 0.2695 0.4345 0.2947 KHDRBS3/CIRBP/FAM172A/AKAP17A/SAP18/CLK1/JMJD6/SRSF8/SREK1/FASTK 10 BP GO:1902749 regulation of cell cycle G2/M phase transition 15/1096 213/18670 0.27 0.4351 0.2951 MECP2/DCTN3/CDC25B/CCND1/AKAP9/SMARCD3/CDK4/CCNB1/CETN2/TPX2/DCTN2/PLK1/FHL1/ATF5/CDC6 15 BP GO:0016574 histone ubiquitination 4/1096 45/18670 0.2705 0.4356 0.2954 HUWE1/PCGF2/PAF1/RING1 4 BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4/1096 45/18670 0.2705 0.4356 0.2954 NUPR1/CD44/DYRK2/DDIT4 4 BP GO:0051985 negative regulation of chromosome segregation 4/1096 45/18670 0.2705 0.4356 0.2954 ATRX/PTTG1/CCNB1/PLK1 4 BP GO:0002675 positive regulation of acute inflammatory response 3/1096 31/18670 0.2731 0.4384 0.2973 ADAM8/IL1B/CCR7 3 BP GO:0006691 leukotriene metabolic process 3/1096 31/18670 0.2731 0.4384 0.2973 LTC4S/TLR2/ALOX5 3 BP GO:0010719 negative regulation of epithelial to mesenchymal transition 3/1096 31/18670 0.2731 0.4384 0.2973 TGFB2/LDLRAD4/SFRP1 3 BP GO:0030431 sleep 3/1096 31/18670 0.2731 0.4384 0.2973 ADA/ADORA1/PTGDS 3 BP GO:0031338 regulation of vesicle fusion 3/1096 31/18670 0.2731 0.4384 0.2973 CORO1A/STXBP1/TBC1D4 3 BP GO:0032786 positive regulation of DNA-templated transcription, elongation 3/1096 31/18670 0.2731 0.4384 0.2973 PAF1/SCAF8/SUPT5H 3 BP GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 3/1096 31/18670 0.2731 0.4384 0.2973 XYLT1/CHST3/UGDH 3 BP GO:0050685 positive regulation of mRNA processing 3/1096 31/18670 0.2731 0.4384 0.2973 CIRBP/PAF1/CCNB1 3 BP GO:0070306 lens fiber cell differentiation 3/1096 31/18670 0.2731 0.4384 0.2973 TMOD1/NTRK3/SMAD3 3 BP GO:0071539 protein localization to centrosome 3/1096 31/18670 0.2731 0.4384 0.2973 SPAG5/DCTN2/STIL 3 BP GO:1902186 regulation of viral release from host cell 3/1096 31/18670 0.2731 0.4384 0.2973 MID2/PC/VAPA 3 BP GO:0008593 regulation of Notch signaling pathway 8/1096 105/18670 0.2748 0.4411 0.2992 TSPAN5/TGFB2/EGFR/POSTN/NFKBIA/GATA2/LFNG/ZMIZ1 8 BP GO:0032515 negative regulation of phosphoprotein phosphatase activity 5/1096 60/18670 0.2757 0.442 0.2998 RGN/MGAT5/PPP1R2/NCKAP1L/PPP1R1A 5 BP GO:0046324 regulation of glucose import 5/1096 60/18670 0.2757 0.442 0.2998 ADIPOQ/ENPP1/ADIPOR2/HK2/INSR 5 BP GO:0051784 negative regulation of nuclear division 5/1096 60/18670 0.2757 0.442 0.2998 ATRX/PTTG1/BMP4/CCNB1/PLK1 5 BP GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 5/1096 60/18670 0.2757 0.442 0.2998 GZMB/ZNF205/BAD/BNIP3/PPP3CC 5 BP GO:1901568 fatty acid derivative metabolic process 12/1096 167/18670 0.2763 0.4429 0.3004 LTC4S/PTGS1/HPGDS/IL1B/GPX4/MAPK3/TECR/OXCT1/GPX1/TLR2/PTGDS/ALOX5 12 BP GO:0007292 female gamete generation 10/1096 136/18670 0.277 0.4437 0.301 IL4R/TNFAIP6/PTK2B/CDC25B/RGS2/ERCC1/CCNB1/ZMIZ1/PLK1/INHBB 10 BP GO:0051028 mRNA transport 11/1096 152/18670 0.2804 0.4492 0.3047 DDX39A/UPF3A/SLBP/MX2/CETN2/IGF2BP3/CDC40/CASC3/NXF1/NUP210/POLDIP3 11 BP GO:0008037 cell recognition 15/1096 215/18670 0.2818 0.4512 0.3061 TRBC1/FCN1/CXCR4/SEMA5A/EPHA3/SEMA3A/CD226/CCR7/CRTAM/PECAM1/IGKC/JMJD6/IGLC1/ALDOA/GAP43 15 BP GO:0002067 glandular epithelial cell differentiation 4/1096 46/18670 0.2838 0.4515 0.3062 HOXA5/BMP4/BAD/RXRA 4 BP GO:0005978 glycogen biosynthetic process 4/1096 46/18670 0.2838 0.4515 0.3062 PPP1R3C/ENPP1/INSR/DYRK2 4 BP GO:0009250 glucan biosynthetic process 4/1096 46/18670 0.2838 0.4515 0.3062 PPP1R3C/ENPP1/INSR/DYRK2 4 BP GO:0022602 ovulation cycle process 4/1096 46/18670 0.2838 0.4515 0.3062 TGFB2/PAM/HSPA5/PDGFRA 4 BP GO:0030810 positive regulation of nucleotide biosynthetic process 4/1096 46/18670 0.2838 0.4515 0.3062 ZBTB20/INSR/HIF1A/PINK1 4 BP GO:0035196 production of miRNAs involved in gene silencing by miRNA 4/1096 46/18670 0.2838 0.4515 0.3062 EGFR/SMAD3/SMAD1/BMP4 4 BP GO:0043631 RNA polyadenylation 4/1096 46/18670 0.2838 0.4515 0.3062 SNRPA/PAF1/SCAF8/SUPT5H 4 BP GO:0045776 negative regulation of blood pressure 4/1096 46/18670 0.2838 0.4515 0.3062 ADIPOQ/ADORA1/GCH1/PTAFR 4 BP GO:0048512 circadian behavior 4/1096 46/18670 0.2838 0.4515 0.3062 ADA/ADORA1/AHCY/PTGDS 4 BP GO:0048599 oocyte development 4/1096 46/18670 0.2838 0.4515 0.3062 PTK2B/CDC25B/CCNB1/INHBB 4 BP GO:1900373 positive regulation of purine nucleotide biosynthetic process 4/1096 46/18670 0.2838 0.4515 0.3062 ZBTB20/INSR/HIF1A/PINK1 4 BP GO:1904738 vascular associated smooth muscle cell migration 4/1096 46/18670 0.2838 0.4515 0.3062 ADIPOQ/PAK1/IGFBP5/PRKG1 4 BP GO:1904752 regulation of vascular associated smooth muscle cell migration 4/1096 46/18670 0.2838 0.4515 0.3062 ADIPOQ/PAK1/IGFBP5/PRKG1 4 BP GO:0006913 nucleocytoplasmic transport 23/1096 343/18670 0.284 0.4515 0.3062 EGR2/ANGPT1/TCF7L2/IL1B/SMAD3/ZIC1/NFKBIA/DDX39A/UPF3A/PKIG/HCLS1/GAS6/BMP4/SLBP/MX2/CDC40/PPM1A/CASC3/NXF1/NUP210/POLDIP3/SNRPD2/PTTG1IP 23 BP GO:0007194 negative regulation of adenylate cyclase activity 2/1096 18/18670 0.2856 0.4515 0.3062 CCR2/AKAP9 2 BP GO:0007250 activation of NF-kappaB-inducing kinase activity 2/1096 18/18670 0.2856 0.4515 0.3062 TNFRSF10B/CHI3L1 2 BP GO:0009200 deoxyribonucleoside triphosphate metabolic process 2/1096 18/18670 0.2856 0.4515 0.3062 ADA/GUK1 2 BP GO:0010612 regulation of cardiac muscle adaptation 2/1096 18/18670 0.2856 0.4515 0.3062 FOXO1/SMAD3 2 BP GO:0010766 negative regulation of sodium ion transport 2/1096 18/18670 0.2856 0.4515 0.3062 SERPINE2/NEDD4L 2 BP GO:0010878 cholesterol storage 2/1096 18/18670 0.2856 0.4515 0.3062 LPL/ABCG1 2 BP GO:0031065 positive regulation of histone deacetylation 2/1096 18/18670 0.2856 0.4515 0.3062 VEGFA/PINK1 2 BP GO:0032693 negative regulation of interleukin-10 production 2/1096 18/18670 0.2856 0.4515 0.3062 FCGR2B/TRIB2 2 BP GO:0042772 DNA damage response, signal transduction resulting in transcription 2/1096 18/18670 0.2856 0.4515 0.3062 KAT5/TFAP4 2 BP GO:0043011 myeloid dendritic cell differentiation 2/1096 18/18670 0.2856 0.4515 0.3062 RELB/BATF 2 BP GO:0045056 transcytosis 2/1096 18/18670 0.2856 0.4515 0.3062 FCGRT/PTAFR 2 BP GO:0048268 clathrin coat assembly 2/1096 18/18670 0.2856 0.4515 0.3062 HIP1/SNAP91 2 BP GO:0048557 embryonic digestive tract morphogenesis 2/1096 18/18670 0.2856 0.4515 0.3062 TCF7/PDGFRA 2 BP GO:0060192 negative regulation of lipase activity 2/1096 18/18670 0.2856 0.4515 0.3062 RGS2/APOC1 2 BP GO:0060546 negative regulation of necroptotic process 2/1096 18/18670 0.2856 0.4515 0.3062 BIRC3/SLC25A4 2 BP GO:0060977 coronary vasculature morphogenesis 2/1096 18/18670 0.2856 0.4515 0.3062 TGFBR3/VEGFA 2 BP GO:0070230 positive regulation of lymphocyte apoptotic process 2/1096 18/18670 0.2856 0.4515 0.3062 CCL5/ADAM8 2 BP GO:0070875 positive regulation of glycogen metabolic process 2/1096 18/18670 0.2856 0.4515 0.3062 INSR/DYRK2 2 BP GO:0071371 cellular response to gonadotropin stimulus 2/1096 18/18670 0.2856 0.4515 0.3062 CCNA2/EFNA5 2 BP GO:0072077 renal vesicle morphogenesis 2/1096 18/18670 0.2856 0.4515 0.3062 BMP4/STAT1 2 BP GO:0072079 nephron tubule formation 2/1096 18/18670 0.2856 0.4515 0.3062 SIX1/GATA3 2 BP GO:0072574 hepatocyte proliferation 2/1096 18/18670 0.2856 0.4515 0.3062 TNFAIP3/XBP1 2 BP GO:0072575 epithelial cell proliferation involved in liver morphogenesis 2/1096 18/18670 0.2856 0.4515 0.3062 TNFAIP3/XBP1 2 BP GO:0097094 craniofacial suture morphogenesis 2/1096 18/18670 0.2856 0.4515 0.3062 BMP4/TWIST1 2 BP GO:0098877 neurotransmitter receptor transport to plasma membrane 2/1096 18/18670 0.2856 0.4515 0.3062 CLSTN1/MAPK10 2 BP GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/1096 18/18670 0.2856 0.4515 0.3062 CLSTN1/MAPK10 2 BP GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/1096 18/18670 0.2856 0.4515 0.3062 BTG2/CNOT1 2 BP GO:1900221 regulation of amyloid-beta clearance 2/1096 18/18670 0.2856 0.4515 0.3062 HDAC1/APOE 2 BP GO:1903019 negative regulation of glycoprotein metabolic process 2/1096 18/18670 0.2856 0.4515 0.3062 HBEGF/APCS 2 BP GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 2/1096 18/18670 0.2856 0.4515 0.3062 FOXO1/SMAD3 2 BP GO:2000047 regulation of cell-cell adhesion mediated by cadherin 2/1096 18/18670 0.2856 0.4515 0.3062 ADAM19/VEGFA 2 BP GO:2000479 regulation of cAMP-dependent protein kinase activity 2/1096 18/18670 0.2856 0.4515 0.3062 ADIPOQ/PKIG 2 BP GO:0051899 membrane depolarization 7/1096 91/18670 0.2859 0.4518 0.3065 ANK3/NEDD4L/CAV3/GOT1/MLLT11/FHL1/JUN 7 BP GO:0006027 glycosaminoglycan catabolic process 5/1096 61/18670 0.2872 0.4538 0.3078 SDC1/CD44/GPC5/HEXA/HYAL1 5 BP GO:0001569 branching involved in blood vessel morphogenesis 3/1096 32/18670 0.2893 0.4548 0.3084 VEGFA/SEMA3E/COL4A1 3 BP GO:0003338 metanephros morphogenesis 3/1096 32/18670 0.2893 0.4548 0.3084 BMP4/BASP1/STAT1 3 BP GO:0007616 long-term memory 3/1096 32/18670 0.2893 0.4548 0.3084 MECP2/APOE/ADCY1 3 BP GO:0015012 heparan sulfate proteoglycan biosynthetic process 3/1096 32/18670 0.2893 0.4548 0.3084 XYLT1/TCF7L2/UGDH 3 BP GO:0032228 regulation of synaptic transmission, GABAergic 3/1096 32/18670 0.2893 0.4548 0.3084 STXBP1/ADORA1/USP46 3 BP GO:0035510 DNA dealkylation 3/1096 32/18670 0.2893 0.4548 0.3084 FTO/GATA3/USP7 3 BP GO:0038128 ERBB2 signaling pathway 3/1096 32/18670 0.2893 0.4548 0.3084 EGFR/HBEGF/BTC 3 BP GO:0039694 viral RNA genome replication 3/1096 32/18670 0.2893 0.4548 0.3084 CXCL8/RAB29/PCBP2 3 BP GO:0042573 retinoic acid metabolic process 3/1096 32/18670 0.2893 0.4548 0.3084 ADH1B/ADH1A/ADH1C 3 BP GO:0051085 chaperone cofactor-dependent protein refolding 3/1096 32/18670 0.2893 0.4548 0.3084 DNAJB5/BAG1/HSPA5 3 BP GO:0051385 response to mineralocorticoid 3/1096 32/18670 0.2893 0.4548 0.3084 NTRK3/CSN1S1/CCND1 3 BP GO:0060325 face morphogenesis 3/1096 32/18670 0.2893 0.4548 0.3084 ASPH/COL1A1/PDGFRA 3 BP GO:0065005 protein-lipid complex assembly 3/1096 32/18670 0.2893 0.4548 0.3084 BIN1/APOC1/APOE 3 BP GO:0099623 regulation of cardiac muscle cell membrane repolarization 3/1096 32/18670 0.2893 0.4548 0.3084 CAV3/AKAP9/SNTA1 3 BP GO:1901661 quinone metabolic process 3/1096 32/18670 0.2893 0.4548 0.3084 AKR1B1/AKR7A2/AKR1B10 3 BP GO:1903955 positive regulation of protein targeting to mitochondrion 3/1096 32/18670 0.2893 0.4548 0.3084 RAC2/HUWE1/PINK1 3 BP GO:1904467 regulation of tumor necrosis factor secretion 3/1096 32/18670 0.2893 0.4548 0.3084 LPL/IL27RA/LILRA2 3 BP GO:1905508 protein localization to microtubule organizing center 3/1096 32/18670 0.2893 0.4548 0.3084 SPAG5/DCTN2/STIL 3 BP GO:2000780 negative regulation of double-strand break repair 3/1096 32/18670 0.2893 0.4548 0.3084 TP53BP1/TWIST1/TFIP11 3 BP GO:0140056 organelle localization by membrane tethering 12/1096 169/18670 0.2899 0.4555 0.3089 STXBP1/STX11/DCTN3/PLEK/ESYT1/STXBP2/AKAP9/UNC13B/B9D1/CETN2/DCTN2/PLK1 12 BP GO:0050905 neuromuscular process 8/1096 107/18670 0.292 0.4587 0.3111 MECP2/GCH1/MYH10/UCHL1/GLRB/ABR/CAMTA1/TCF15 8 BP GO:0043687 post-translational protein modification 24/1096 361/18670 0.2929 0.4599 0.312 SPP1/ZBTB16/SERPINA1/DCAF8/IGFBP7/APLP2/MXRA8/SPARCL1/GAS6/HIF1A/CRTAP/BMP4/FBXO9/CP/IGFBP5/APOE/KTN1/LAMB2/ASB1/CDH2/WFS1/CUL4A/UBA3/FBXL14 24 BP GO:0006352 DNA-templated transcription, initiation 17/1096 249/18670 0.2947 0.4626 0.3138 MECP2/WWTR1/THRA/NR3C2/MAPK3/CCND1/AR/CDK4/CCNB1/POLR2E/CTNNBIP1/TWIST1/CDK8/POLR2I/POLR1C/RXRA/JUN 17 BP GO:0010770 positive regulation of cell morphogenesis involved in differentiation 11/1096 154/18670 0.2947 0.4626 0.3138 SEMA5A/VEGFA/NTRK3/CUX1/PAK1/DOCK1/EFNA5/NGF/PLXNC1/PLXNA2/CXCL12 11 BP GO:0008206 bile acid metabolic process 4/1096 47/18670 0.2972 0.4658 0.3159 CH25H/NPC1/SLC27A2/ACOX2 4 BP GO:0050435 amyloid-beta metabolic process 4/1096 47/18670 0.2972 0.4658 0.3159 BIN1/ABCG1/PIN1/APOE 4 BP GO:0060351 cartilage development involved in endochondral bone morphogenesis 4/1096 47/18670 0.2972 0.4658 0.3159 STC1/COL1A1/CARM1/HOXA11 4 BP GO:0098868 bone growth 4/1096 47/18670 0.2972 0.4658 0.3159 DDR2/STC1/CARM1/FGFR3 4 BP GO:0120163 negative regulation of cold-induced thermogenesis 4/1096 47/18670 0.2972 0.4658 0.3159 NOVA1/ADIPOQ/ID1/IL15 4 BP GO:0051937 catecholamine transport 6/1096 77/18670 0.2977 0.4665 0.3164 MECP2/SYT17/PINK1/SNCG/CXCL12/SLC18A2 6 BP GO:1902305 regulation of sodium ion transmembrane transport 5/1096 62/18670 0.2988 0.4679 0.3174 ANK3/FXYD1/NEDD4L/CAV3/SNTA1 5 BP GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 5/1096 62/18670 0.2988 0.4679 0.3174 GZMB/ZNF205/BAD/BNIP3/PPP3CC 5 BP GO:0042742 defense response to bacterium 22/1096 330/18670 0.2989 0.4679 0.3174 TRBC1/RARRES2/CXCL13/SLPI/IL27RA/S100A9/MYD88/CFP/CXCL6/IRF8/UNC13B/IGKC/GBP2/TLR2/SERPINE1/GNLY/LPO/LBP/NLRP3/IGLC1/SELP/ELANE 22 BP GO:0007098 centrosome cycle 9/1096 124/18670 0.3046 0.4749 0.3221 ARL2/ARHGEF10/KIF3B/PLK2/CETN2/PLK1/SPICE1/STIL/ATF5 9 BP GO:0032092 positive regulation of protein binding 7/1096 93/18670 0.3047 0.4749 0.3221 TCF7L2/MAPRE3/PLK2/PIN1/BMP4/LFNG/APOE 7 BP GO:0036473 cell death in response to oxidative stress 7/1096 93/18670 0.3047 0.4749 0.3221 HSPB1/NOL3/TRAP1/HIF1A/PINK1/GPX1/MAPK7 7 BP GO:0070646 protein modification by small protein removal 20/1096 299/18670 0.305 0.4749 0.3221 TNFAIP3/GATA3/BIRC3/SMAD3/NFKBIA/USP11/SMAD1/AR/HIF1A/UCHL1/CCNA2/USP7/TADA3/USP46/EIF3F/RAD23B/NLRP3/TRAF3/USP5/IKBKG 20 BP GO:0001914 regulation of T cell mediated cytotoxicity 3/1096 33/18670 0.3057 0.4749 0.3221 IL7R/FCGR2B/PTPRC 3 BP GO:0006370 7-methylguanosine mRNA capping 3/1096 33/18670 0.3057 0.4749 0.3221 POLR2E/POLR2I/SUPT5H 3 BP GO:0010039 response to iron ion 3/1096 33/18670 0.3057 0.4749 0.3221 CCND1/HIF1A/CCNB1 3 BP GO:0014072 response to isoquinoline alkaloid 3/1096 33/18670 0.3057 0.4749 0.3221 CXCR4/ADA/GOT2 3 BP GO:0016242 negative regulation of macroautophagy 3/1096 33/18670 0.3057 0.4749 0.3221 NUPR1/NPC1/PINK1 3 BP GO:0030513 positive regulation of BMP signaling pathway 3/1096 33/18670 0.3057 0.4749 0.3221 SULF1/CDH5/BMP4 3 BP GO:0032691 negative regulation of interleukin-1 beta production 3/1096 33/18670 0.3057 0.4749 0.3221 TNFAIP3/CX3CR1/NLRP3 3 BP GO:0035115 embryonic forelimb morphogenesis 3/1096 33/18670 0.3057 0.4749 0.3221 TWIST1/OSR2/HOXA11 3 BP GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/1096 33/18670 0.3057 0.4749 0.3221 OXCT1/HIF1A/BAD 3 BP GO:0040001 establishment of mitotic spindle localization 3/1096 33/18670 0.3057 0.4749 0.3221 GPSM2/PLK1/SPRY1 3 BP GO:0043278 response to morphine 3/1096 33/18670 0.3057 0.4749 0.3221 CXCR4/ADA/GOT2 3 BP GO:0048821 erythrocyte development 3/1096 33/18670 0.3057 0.4749 0.3221 JMJD6/NCKAP1L/TRIM58 3 BP GO:0051204 protein insertion into mitochondrial membrane 3/1096 33/18670 0.3057 0.4749 0.3221 GZMB/BAD/PPP3CC 3 BP GO:0051443 positive regulation of ubiquitin-protein transferase activity 3/1096 33/18670 0.3057 0.4749 0.3221 PIN1/PINK1/PLK1 3 BP GO:0051955 regulation of amino acid transport 3/1096 33/18670 0.3057 0.4749 0.3221 STXBP1/ADORA1/RGS2 3 BP GO:0060603 mammary gland duct morphogenesis 3/1096 33/18670 0.3057 0.4749 0.3221 AR/CAV3/LRP5 3 BP GO:1901797 negative regulation of signal transduction by p53 class mediator 3/1096 33/18670 0.3057 0.4749 0.3221 CD44/TWIST1/PTTG1IP 3 BP GO:2001024 negative regulation of response to drug 3/1096 33/18670 0.3057 0.4749 0.3221 RGS2/TRAP1/PINK1 3 BP GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/1096 19/18670 0.3078 0.4749 0.3221 CPA3/F2R 2 BP GO:0006337 nucleosome disassembly 2/1096 19/18670 0.3078 0.4749 0.3221 HMGA1/SMARCD3 2 BP GO:0006555 methionine metabolic process 2/1096 19/18670 0.3078 0.4749 0.3221 AHCY/AHCYL2 2 BP GO:0006833 water transport 2/1096 19/18670 0.3078 0.4749 0.3221 AQP9/AQP1 2 BP GO:0010985 negative regulation of lipoprotein particle clearance 2/1096 19/18670 0.3078 0.4749 0.3221 APOC1/CSK 2 BP GO:0016082 synaptic vesicle priming 2/1096 19/18670 0.3078 0.4749 0.3221 STXBP1/UNC13B 2 BP GO:0016973 poly(A)+ mRNA export from nucleus 2/1096 19/18670 0.3078 0.4749 0.3221 NXF1/POLDIP3 2 BP GO:0030859 polarized epithelial cell differentiation 2/1096 19/18670 0.3078 0.4749 0.3221 DLG5/TCF15 2 BP GO:0032700 negative regulation of interleukin-17 production 2/1096 19/18670 0.3078 0.4749 0.3221 IL27RA/NCKAP1L 2 BP GO:0032930 positive regulation of superoxide anion generation 2/1096 19/18670 0.3078 0.4749 0.3221 EGFR/ITGB2 2 BP GO:0034063 stress granule assembly 2/1096 19/18670 0.3078 0.4749 0.3221 CIRBP/G3BP1 2 BP GO:0045063 T-helper 1 cell differentiation 2/1096 19/18670 0.3078 0.4749 0.3221 IL4R/RELB 2 BP GO:0046112 nucleobase biosynthetic process 2/1096 19/18670 0.3078 0.4749 0.3221 ADA/HPRT1 2 BP GO:0046641 positive regulation of alpha-beta T cell proliferation 2/1096 19/18670 0.3078 0.4749 0.3221 PTPRC/CCR2 2 BP GO:0046653 tetrahydrofolate metabolic process 2/1096 19/18670 0.3078 0.4749 0.3221 GCH1/MTHFD2 2 BP GO:0051131 chaperone-mediated protein complex assembly 2/1096 19/18670 0.3078 0.4749 0.3221 HOPX/APCS 2 BP GO:0051546 keratinocyte migration 2/1096 19/18670 0.3078 0.4749 0.3221 MAPRE2/HBEGF 2 BP GO:0060219 camera-type eye photoreceptor cell differentiation 2/1096 19/18670 0.3078 0.4749 0.3221 THY1/DIO3 2 BP GO:0060252 positive regulation of glial cell proliferation 2/1096 19/18670 0.3078 0.4749 0.3221 IL1B/PRKCH 2 BP GO:0070989 oxidative demethylation 2/1096 19/18670 0.3078 0.4749 0.3221 FTO/JMJD6 2 BP GO:0071243 cellular response to arsenic-containing substance 2/1096 19/18670 0.3078 0.4749 0.3221 DAXX/MAPK13 2 BP GO:0072087 renal vesicle development 2/1096 19/18670 0.3078 0.4749 0.3221 BMP4/STAT1 2 BP GO:0072576 liver morphogenesis 2/1096 19/18670 0.3078 0.4749 0.3221 TNFAIP3/XBP1 2 BP GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/1096 19/18670 0.3078 0.4749 0.3221 NOL3/GPX1 2 BP GO:1903540 establishment of protein localization to postsynaptic membrane 2/1096 19/18670 0.3078 0.4749 0.3221 CLSTN1/MAPK10 2 BP GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/1096 19/18670 0.3078 0.4749 0.3221 EGFR/BMP4 2 BP GO:1990182 exosomal secretion 2/1096 19/18670 0.3078 0.4749 0.3221 SDC1/RAB27A 2 BP GO:2000010 positive regulation of protein localization to cell surface 2/1096 19/18670 0.3078 0.4749 0.3221 CD247/TM9SF4 2 BP GO:0008589 regulation of smoothened signaling pathway 6/1096 78/18670 0.3081 0.4749 0.3221 SERPINE2/ENPP1/ZIC1/DLG5/GAS1/SFRP1 6 BP GO:0030433 ubiquitin-dependent ERAD pathway 6/1096 78/18670 0.3081 0.4749 0.3221 HSPA5/RNF103/UBE4B/UBE2J1/WFS1/HERPUD1 6 BP GO:0032413 negative regulation of ion transmembrane transporter activity 6/1096 78/18670 0.3081 0.4749 0.3221 ANK3/NEDD4L/PLN/CASQ2/KCNAB1/CAV3 6 BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 6/1096 78/18670 0.3081 0.4749 0.3221 NUPR1/CD44/PDK2/DYRK2/DDIT4/PTTG1IP 6 BP GO:0072347 response to anesthetic 6/1096 78/18670 0.3081 0.4749 0.3221 CXCR4/ADA/PTK2B/GOT2/HSPA5/CCNA2 6 BP GO:0090398 cellular senescence 6/1096 78/18670 0.3081 0.4749 0.3221 HMGA1/AKT3/NAMPT/PLK2/BMPR1A/TWIST1 6 BP GO:1903313 positive regulation of mRNA metabolic process 6/1096 78/18670 0.3081 0.4749 0.3221 FTO/CIRBP/BTG2/CNOT1/PAF1/CCNB1 6 BP GO:2000300 regulation of synaptic vesicle exocytosis 6/1096 78/18670 0.3081 0.4749 0.3221 STXBP1/PRKCB/UNC13B/RIMS3/PFN2/ADCY1 6 BP GO:0006289 nucleotide-excision repair 8/1096 109/18670 0.3095 0.4768 0.3234 ERCC1/POLR2E/FANCC/USP7/CETN2/RAD23B/POLR2I/CUL4A 8 BP GO:0006893 Golgi to plasma membrane transport 5/1096 63/18670 0.3105 0.4777 0.324 ANK3/SPTBN1/CSK/ARF3/LYPLA1 5 BP GO:0051262 protein tetramerization 12/1096 172/18670 0.3106 0.4777 0.324 CD247/CCL5/GPX3/PFKM/INSR/HPRT1/ALDH5A1/PCBD1/CBY1/IMPDH2/RXRA/ALDOA 12 BP GO:0002711 positive regulation of T cell mediated immunity 4/1096 48/18670 0.3106 0.4777 0.324 GATA3/IL1B/PTPRC/NLRP3 4 BP GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 4/1096 48/18670 0.3106 0.4777 0.324 CDH5/SELL/CDH2/SELP 4 BP GO:0051653 spindle localization 4/1096 48/18670 0.3106 0.4777 0.324 GPSM2/MAP4/PLK1/SPRY1 4 BP GO:0051972 regulation of telomerase activity 4/1096 48/18670 0.3106 0.4777 0.324 PARM1/MAPK3/MAP3K4/PARP3 4 BP GO:0060324 face development 4/1096 48/18670 0.3106 0.4777 0.324 MAPK3/ASPH/COL1A1/PDGFRA 4 BP GO:0006367 transcription initiation from RNA polymerase II promoter 13/1096 188/18670 0.3114 0.4787 0.3247 MECP2/WWTR1/THRA/NR3C2/CCND1/AR/CDK4/CCNB1/POLR2E/CTNNBIP1/CDK8/POLR2I/RXRA 13 BP GO:0006805 xenobiotic metabolic process 9/1096 125/18670 0.3128 0.4806 0.326 PTGS1/AOC3/CYB5R3/BPHL/CDO1/AKR7A2/GSTA4/NQO1/LPO 9 BP GO:0031929 TOR signaling 9/1096 125/18670 0.3128 0.4806 0.326 AKT3/GATA3/SIK1/GAS6/HIF1A/PINK1/FBXO9/DDIT4/NPRL3 9 BP GO:0044728 DNA methylation or demethylation 7/1096 94/18670 0.3142 0.4826 0.3274 FTO/MECP2/GATA3/ATRX/EHMT2/USP7/MBD2 7 BP GO:0006836 neurotransmitter transport 18/1096 269/18670 0.317 0.4868 0.3302 SV2B/HBB/STXBP1/STX11/ADA/PRKCB/PRAF2/RGS2/SLC29A1/ICA1/SYT17/UNC13B/AQP1/SNCG/RIMS3/PFN2/SLC18A2/ADCY1 18 BP GO:0019362 pyridine nucleotide metabolic process 13/1096 189/18670 0.3181 0.4882 0.3311 ZBTB20/NUPR1/NAMPT/PFKM/HK2/CD38/INSR/HIF1A/PGD/HDAC4/DDIT4/NUP210/ALDOA 13 BP GO:0046496 nicotinamide nucleotide metabolic process 13/1096 189/18670 0.3181 0.4882 0.3311 ZBTB20/NUPR1/NAMPT/PFKM/HK2/CD38/INSR/HIF1A/PGD/HDAC4/DDIT4/NUP210/ALDOA 13 BP GO:0006664 glycolipid metabolic process 8/1096 110/18670 0.3183 0.4882 0.3312 UGCG/ESYT1/GPAA1/ALDH5A1/PGAP2/HEXA/STS/NAGA 8 BP GO:0032508 DNA duplex unwinding 8/1096 110/18670 0.3183 0.4882 0.3312 HMGA1/CHD9/ATRX/PURA/CETN2/G3BP1/RAD23B/CUL4A 8 BP GO:0006536 glutamate metabolic process 3/1096 34/18670 0.3221 0.492 0.3337 GOT2/ALDH5A1/GOT1 3 BP GO:0009452 7-methylguanosine RNA capping 3/1096 34/18670 0.3221 0.492 0.3337 POLR2E/POLR2I/SUPT5H 3 BP GO:0016601 Rac protein signal transduction 3/1096 34/18670 0.3221 0.492 0.3337 RAC2/AUTS2/NCKAP1 3 BP GO:0036260 RNA capping 3/1096 34/18670 0.3221 0.492 0.3337 POLR2E/POLR2I/SUPT5H 3 BP GO:0043276 anoikis 3/1096 34/18670 0.3221 0.492 0.3337 SIK1/ITGA5/IKBKG 3 BP GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 3/1096 34/18670 0.3221 0.492 0.3337 CD44/TWIST1/PTTG1IP 3 BP GO:0045738 negative regulation of DNA repair 3/1096 34/18670 0.3221 0.492 0.3337 TP53BP1/TWIST1/TFIP11 3 BP GO:0045920 negative regulation of exocytosis 3/1096 34/18670 0.3221 0.492 0.3337 FCGR2B/CCR2/ABR 3 BP GO:0070050 neuron cellular homeostasis 3/1096 34/18670 0.3221 0.492 0.3337 CALB2/ADORA1/TYRO3 3 BP GO:0071875 adrenergic receptor signaling pathway 3/1096 34/18670 0.3221 0.492 0.3337 ADCY9/PLN/RGS2 3 BP GO:0006826 iron ion transport 5/1096 64/18670 0.3222 0.492 0.3337 ARHGAP1/CP/SLC39A14/TFRC/ATP6V0D1 5 BP GO:0035773 insulin secretion involved in cellular response to glucose stimulus 5/1096 64/18670 0.3222 0.492 0.3337 OXCT1/HIF1A/EFNA5/LRP5/BAD 5 BP GO:0035794 positive regulation of mitochondrial membrane permeability 5/1096 64/18670 0.3222 0.492 0.3337 GZMB/ZNF205/BAD/BNIP3/PPP3CC 5 BP GO:0045670 regulation of osteoclast differentiation 5/1096 64/18670 0.3222 0.492 0.3337 TCTA/LILRB4/LILRB3/INPP5D/SFRP1 5 BP GO:0048278 vesicle docking 5/1096 64/18670 0.3222 0.492 0.3337 STXBP1/STX11/PLEK/STXBP2/UNC13B 5 BP GO:0050432 catecholamine secretion 5/1096 64/18670 0.3222 0.492 0.3337 MECP2/SYT17/PINK1/SNCG/CXCL12 5 BP GO:1900449 regulation of glutamate receptor signaling pathway 5/1096 64/18670 0.3222 0.492 0.3337 PTK2B/SHANK2/CCR2/PINK1/CCL2 5 BP GO:0051952 regulation of amine transport 7/1096 95/18670 0.3238 0.4943 0.3352 STXBP1/ADORA1/RGS2/SYT17/PINK1/SNCG/CXCL12 7 BP GO:0010712 regulation of collagen metabolic process 4/1096 49/18670 0.3241 0.4943 0.3353 MFAP4/F2R/GOT1/BMP4 4 BP GO:0030857 negative regulation of epithelial cell differentiation 4/1096 49/18670 0.3241 0.4943 0.3353 VEGFA/CCND1/ID1/STAT1 4 BP GO:0051445 regulation of meiotic cell cycle 4/1096 49/18670 0.3241 0.4943 0.3353 PLCB1/CDC25B/INSR/LFNG 4 BP GO:0097300 programmed necrotic cell death 4/1096 49/18670 0.3241 0.4943 0.3353 BIRC3/LY96/CD14/SLC25A4 4 BP GO:0015711 organic anion transport 31/1096 482/18670 0.3246 0.4948 0.3356 CA12/NFKBIE/ATP9A/ABCC3/HBB/FABP4/STXBP1/IL1B/CYB5R1/ADORA1/SLC1A4/PRAF2/SLC23A2/GOT2/NMB/RGS2/PDPN/AQP9/SLC7A8/ABCG1/SLC27A2/SLC7A5/APOC1/UNC13B/NFE2L1/ABCC5/AQP1/APOE/CA3/SLC25A4/RXRA 31 BP GO:0006650 glycerophospholipid metabolic process 21/1096 319/18670 0.325 0.4953 0.3359 PLCB1/MECP2/PTPN13/PIP4K2B/CPNE1/PLEK/PNPLA6/LIPC/PLSCR1/PLCG2/SH3YL1/APOC1/GPAA1/INPP5F/ALDH5A1/PGAP2/PLA2G7/ARF3/INPP5D/AGPAT1/PLA2G15 21 BP GO:0035305 negative regulation of dephosphorylation 8/1096 111/18670 0.3271 0.4983 0.338 TGFB2/RGN/MFHAS1/MGAT5/PPP1R2/NCKAP1L/PPP1R1A/RIMBP2 8 BP GO:0098661 inorganic anion transmembrane transport 8/1096 111/18670 0.3271 0.4983 0.338 GABRB1/CLIC5/FXYD1/SLC1A4/SLC20A1/PTAFR/SLC20A2/GLRB 8 BP GO:0034765 regulation of ion transmembrane transport 31/1096 483/18670 0.3288 0.4985 0.3381 CORO1A/P2RY6/ANK3/BIN1/PTK2B/SHANK2/CLIC5/FXYD1/NEDD4L/PLN/PTPN6/RGN/PTAFR/RGS2/KCNJ8/CASQ2/KCNAB1/PLCG2/CCR2/CAV3/AKAP9/F2R/THY1/PINK1/ATP2A1/SNTA1/CXCL10/KCNB2/TWIST1/CCL2/FHL1 31 BP GO:0070509 calcium ion import 6/1096 80/18670 0.3291 0.4985 0.3381 STC1/PLN/CAV3/ATP2A1/CXCL12/CCL2 6 BP GO:0001502 cartilage condensation 2/1096 20/18670 0.3299 0.4985 0.3381 THRA/MGP 2 BP GO:0003323 type B pancreatic cell development 2/1096 20/18670 0.3299 0.4985 0.3381 BMP4/BAD 2 BP GO:0006525 arginine metabolic process 2/1096 20/18670 0.3299 0.4985 0.3381 FAH/ASS1 2 BP GO:0007620 copulation 2/1096 20/18670 0.3299 0.4985 0.3381 SERPINE2/ADA 2 BP GO:0008356 asymmetric cell division 2/1096 20/18670 0.3299 0.4985 0.3381 ZBTB16/SOX5 2 BP GO:0019370 leukotriene biosynthetic process 2/1096 20/18670 0.3299 0.4985 0.3381 LTC4S/ALOX5 2 BP GO:0023019 signal transduction involved in regulation of gene expression 2/1096 20/18670 0.3299 0.4985 0.3381 SMAD3/PDGFRA 2 BP GO:0030220 platelet formation 2/1096 20/18670 0.3299 0.4985 0.3381 ACTN1/PTPN6 2 BP GO:0031280 negative regulation of cyclase activity 2/1096 20/18670 0.3299 0.4985 0.3381 CCR2/AKAP9 2 BP GO:0032462 regulation of protein homooligomerization 2/1096 20/18670 0.3299 0.4985 0.3381 CRYAB/APOE 2 BP GO:0032769 negative regulation of monooxygenase activity 2/1096 20/18670 0.3299 0.4985 0.3381 NFKB1/CAV3 2 BP GO:0042053 regulation of dopamine metabolic process 2/1096 20/18670 0.3299 0.4985 0.3381 HPRT1/ITGB2 2 BP GO:0042069 regulation of catecholamine metabolic process 2/1096 20/18670 0.3299 0.4985 0.3381 HPRT1/ITGB2 2 BP GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 2/1096 20/18670 0.3299 0.4985 0.3381 RUNX3/IL4R 2 BP GO:0046823 negative regulation of nucleocytoplasmic transport 2/1096 20/18670 0.3299 0.4985 0.3381 ANGPT1/PKIG 2 BP GO:0051016 barbed-end actin filament capping 2/1096 20/18670 0.3299 0.4985 0.3381 GSN/CAPG 2 BP GO:0060216 definitive hemopoiesis 2/1096 20/18670 0.3299 0.4985 0.3381 TGFBR3/GATA2 2 BP GO:0070828 heterochromatin organization 2/1096 20/18670 0.3299 0.4985 0.3381 LOXL2/HMGA1 2 BP GO:0070932 histone H3 deacetylation 2/1096 20/18670 0.3299 0.4985 0.3381 HDAC1/HDAC4 2 BP GO:0071397 cellular response to cholesterol 2/1096 20/18670 0.3299 0.4985 0.3381 DAG1/NFE2L1 2 BP GO:0071636 positive regulation of transforming growth factor beta production 2/1096 20/18670 0.3299 0.4985 0.3381 CD200/SMAD3 2 BP GO:0072234 metanephric nephron tubule development 2/1096 20/18670 0.3299 0.4985 0.3381 WWTR1/STAT1 2 BP GO:0097709 connective tissue replacement 2/1096 20/18670 0.3299 0.4985 0.3381 HIF1A/F2R 2 BP GO:0097734 extracellular exosome biogenesis 2/1096 20/18670 0.3299 0.4985 0.3381 SDC1/RAB27A 2 BP GO:0098780 response to mitochondrial depolarisation 2/1096 20/18670 0.3299 0.4985 0.3381 HK2/PINK1 2 BP GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/1096 20/18670 0.3299 0.4985 0.3381 BTG2/CNOT1 2 BP GO:1900424 regulation of defense response to bacterium 2/1096 20/18670 0.3299 0.4985 0.3381 CXCL6/UNC13B 2 BP GO:1903204 negative regulation of oxidative stress-induced neuron death 2/1096 20/18670 0.3299 0.4985 0.3381 HIF1A/PINK1 2 BP GO:0006665 sphingolipid metabolic process 11/1096 159/18670 0.3313 0.5006 0.3395 UGCG/TECR/ESYT1/ALDH5A1/ALDH3B1/HEXA/ALDH3A2/PLA2G15/STS/VAPA/NAGA 11 BP GO:0071478 cellular response to radiation 13/1096 191/18670 0.3315 0.5007 0.3396 CRYAB/ADIRF/MFAP4/GATA3/NAMPT/TP53BP1/HSPA5/ERCC1/AQP1/MAPK13/SFRP1/EEF1D/HYAL1 13 BP GO:0098876 vesicle-mediated transport to the plasma membrane 7/1096 96/18670 0.3334 0.5034 0.3414 ANK3/CLSTN1/SPTBN1/MAPK10/CSK/ARF3/LYPLA1 7 BP GO:0006026 aminoglycan catabolic process 5/1096 65/18670 0.334 0.5041 0.3419 SDC1/CD44/GPC5/HEXA/HYAL1 5 BP GO:0006813 potassium ion transport 16/1096 240/18670 0.336 0.5068 0.3438 ANK3/BIN1/PTK2B/FXYD1/ADORA1/NEDD4L/KCNJ8/CASQ2/KCNAB1/ATP4B/CAV3/AKAP9/AQP1/KCNB2/KCNN3/FHL1 16 BP GO:0006354 DNA-templated transcription, elongation 8/1096 112/18670 0.336 0.5068 0.3438 HTATSF1/PAF1/POLR2E/TCEA2/SCAF8/POLR2I/POLR1C/SUPT5H 8 BP GO:0015918 sterol transport 8/1096 112/18670 0.336 0.5068 0.3438 ADIPOQ/NFKBIA/NFKB1/LIPC/NPC1/ABCG1/APOC1/APOE 8 BP GO:0014009 glial cell proliferation 4/1096 50/18670 0.3377 0.5076 0.3443 PTK2B/IL1B/EEF2/PRKCH 4 BP GO:0034656 nucleobase-containing small molecule catabolic process 4/1096 50/18670 0.3377 0.5076 0.3443 ADA/HPRT1/AHCY/TYMP 4 BP GO:0045104 intermediate filament cytoskeleton organization 4/1096 50/18670 0.3377 0.5076 0.3443 SYNM/PPL/DES/DST 4 BP GO:1903793 positive regulation of anion transport 4/1096 50/18670 0.3377 0.5076 0.3443 STXBP1/IL1B/PTAFR/APOE 4 BP GO:0044272 sulfur compound biosynthetic process 13/1096 192/18670 0.3383 0.5076 0.3443 UST/XYLT1/ANGPT1/HPGDS/TECR/PDK2/B4GALT2/CDO1/CHST3/GSTA4/PAPSS2/GSTT1/UGDH 13 BP GO:0000266 mitochondrial fission 3/1096 35/18670 0.3385 0.5076 0.3443 PINK1/MX2/BNIP3 3 BP GO:0001881 receptor recycling 3/1096 35/18670 0.3385 0.5076 0.3443 RAB29/INPP5F/CAMLG 3 BP GO:0003203 endocardial cushion morphogenesis 3/1096 35/18670 0.3385 0.5076 0.3443 TGFB2/BMPR1A/TWIST1 3 BP GO:0019076 viral release from host cell 3/1096 35/18670 0.3385 0.5076 0.3443 MID2/PC/VAPA 3 BP GO:0032689 negative regulation of interferon-gamma production 3/1096 35/18670 0.3385 0.5076 0.3443 AXL/GATA3/GAS6 3 BP GO:0032801 receptor catabolic process 3/1096 35/18670 0.3385 0.5076 0.3443 GPRASP1/APOE/LGMN 3 BP GO:0033363 secretory granule organization 3/1096 35/18670 0.3385 0.5076 0.3443 SERPINE2/SRGN/F2R 3 BP GO:0035890 exit from host 3/1096 35/18670 0.3385 0.5076 0.3443 MID2/PC/VAPA 3 BP GO:0035891 exit from host cell 3/1096 35/18670 0.3385 0.5076 0.3443 MID2/PC/VAPA 3 BP GO:0042462 eye photoreceptor cell development 3/1096 35/18670 0.3385 0.5076 0.3443 VEGFA/THY1/DIO3 3 BP GO:0045622 regulation of T-helper cell differentiation 3/1096 35/18670 0.3385 0.5076 0.3443 IL4R/CD86/NLRP3 3 BP GO:0051954 positive regulation of amine transport 3/1096 35/18670 0.3385 0.5076 0.3443 STXBP1/PINK1/CXCL12 3 BP GO:0052126 movement in host environment 3/1096 35/18670 0.3385 0.5076 0.3443 MID2/PC/VAPA 3 BP GO:0052192 movement in environment of other organism involved in symbiotic interaction 3/1096 35/18670 0.3385 0.5076 0.3443 MID2/PC/VAPA 3 BP GO:0071108 protein K48-linked deubiquitination 3/1096 35/18670 0.3385 0.5076 0.3443 TNFAIP3/USP7/USP5 3 BP GO:1903539 protein localization to postsynaptic membrane 3/1096 35/18670 0.3385 0.5076 0.3443 CLSTN1/DAG1/MAPK10 3 BP GO:1990774 tumor necrosis factor secretion 3/1096 35/18670 0.3385 0.5076 0.3443 LPL/IL27RA/LILRA2 3 BP GO:0006754 ATP biosynthetic process 11/1096 160/18670 0.3388 0.5079 0.3445 ZBTB20/NUPR1/PFKM/HK2/INSR/HIF1A/PINK1/HDAC4/DDIT4/NUP210/ALDOA 11 BP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 6/1096 81/18670 0.3397 0.5089 0.3452 RNF144A/TRIB2/PLK2/PLK1/USP5/HERPUD1 6 BP GO:1903533 regulation of protein targeting 6/1096 81/18670 0.3397 0.5089 0.3452 RAC2/HUWE1/ANK3/PAK1/PINK1/ITGB2 6 BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 7/1096 97/18670 0.343 0.5138 0.3485 MECP2/PINK1/CCNB1/COX6A2/NDUFB7/NDUFV1/UQCRC1 7 BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 8/1096 113/18670 0.345 0.5166 0.3504 RELB/CLEC10A/PAK1/NFKB1/PLCG2/PAK2/NRAS/IKBKG 8 BP GO:0021872 forebrain generation of neurons 5/1096 66/18670 0.3458 0.5174 0.351 SEMA3A/FGFR1/GATA2/NRP2/ATF5 5 BP GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 5/1096 66/18670 0.3458 0.5174 0.351 CLSTN1/DAG1/DNM1/MAPK10/USP46 5 BP GO:1905710 positive regulation of membrane permeability 5/1096 66/18670 0.3458 0.5174 0.351 GZMB/ZNF205/BAD/BNIP3/PPP3CC 5 BP GO:0071158 positive regulation of cell cycle arrest 6/1096 82/18670 0.3502 0.5207 0.3532 BTG2/CNOT1/PLK2/CCNB1/CNOT4/CARM1 6 BP GO:0006213 pyrimidine nucleoside metabolic process 4/1096 51/18670 0.3513 0.5207 0.3532 DCK/NME3/TYMP/TK2 4 BP GO:0009994 oocyte differentiation 4/1096 51/18670 0.3513 0.5207 0.3532 PTK2B/CDC25B/CCNB1/INHBB 4 BP GO:0019369 arachidonic acid metabolic process 4/1096 51/18670 0.3513 0.5207 0.3532 PTGS1/HPGDS/MAPK3/PTGDS 4 BP GO:0021545 cranial nerve development 4/1096 51/18670 0.3513 0.5207 0.3532 EGR2/SEMA3A/SIX1/NRP2 4 BP GO:0031050 dsRNA processing 4/1096 51/18670 0.3513 0.5207 0.3532 EGFR/SMAD3/SMAD1/BMP4 4 BP GO:0032007 negative regulation of TOR signaling 4/1096 51/18670 0.3513 0.5207 0.3532 SIK1/HIF1A/DDIT4/NPRL3 4 BP GO:0032206 positive regulation of telomere maintenance 4/1096 51/18670 0.3513 0.5207 0.3532 ATRX/MAPK3/MAP3K4/ERCC1 4 BP GO:0045103 intermediate filament-based process 4/1096 51/18670 0.3513 0.5207 0.3532 SYNM/PPL/DES/DST 4 BP GO:0048641 regulation of skeletal muscle tissue development 4/1096 51/18670 0.3513 0.5207 0.3532 CDON/SIX1/HDAC4/TWIST1 4 BP GO:0070918 production of small RNA involved in gene silencing by RNA 4/1096 51/18670 0.3513 0.5207 0.3532 EGFR/SMAD3/SMAD1/BMP4 4 BP GO:0001956 positive regulation of neurotransmitter secretion 2/1096 21/18670 0.3517 0.5207 0.3532 STXBP1/UNC13B 2 BP GO:0006144 purine nucleobase metabolic process 2/1096 21/18670 0.3517 0.5207 0.3532 ADA/HPRT1 2 BP GO:0006293 nucleotide-excision repair, preincision complex stabilization 2/1096 21/18670 0.3517 0.5207 0.3532 ERCC1/CUL4A 2 BP GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion 2/1096 21/18670 0.3517 0.5207 0.3532 ERCC1/CUL4A 2 BP GO:0010893 positive regulation of steroid biosynthetic process 2/1096 21/18670 0.3517 0.5207 0.3532 IL1B/ABCG1 2 BP GO:0031498 chromatin disassembly 2/1096 21/18670 0.3517 0.5207 0.3532 HMGA1/SMARCD3 2 BP GO:0032516 positive regulation of phosphoprotein phosphatase activity 2/1096 21/18670 0.3517 0.5207 0.3532 MAGI2/PTPRC 2 BP GO:0032891 negative regulation of organic acid transport 2/1096 21/18670 0.3517 0.5207 0.3532 ADORA1/RGS2 2 BP GO:0032986 protein-DNA complex disassembly 2/1096 21/18670 0.3517 0.5207 0.3532 HMGA1/SMARCD3 2 BP GO:0035590 purinergic nucleotide receptor signaling pathway 2/1096 21/18670 0.3517 0.5207 0.3532 P2RY6/PTAFR 2 BP GO:0035813 regulation of renal sodium excretion 2/1096 21/18670 0.3517 0.5207 0.3532 ADORA1/AGTR1 2 BP GO:0036120 cellular response to platelet-derived growth factor stimulus 2/1096 21/18670 0.3517 0.5207 0.3532 CCNA2/HYAL1 2 BP GO:0036344 platelet morphogenesis 2/1096 21/18670 0.3517 0.5207 0.3532 ACTN1/PTPN6 2 BP GO:0042135 neurotransmitter catabolic process 2/1096 21/18670 0.3517 0.5207 0.3532 MAOA/ALDH5A1 2 BP GO:0043984 histone H4-K16 acetylation 2/1096 21/18670 0.3517 0.5207 0.3532 AUTS2/MSL3 2 BP GO:0051412 response to corticosterone 2/1096 21/18670 0.3517 0.5207 0.3532 NTRK3/CCND1 2 BP GO:0051900 regulation of mitochondrial depolarization 2/1096 21/18670 0.3517 0.5207 0.3532 GOT1/MLLT11 2 BP GO:0060044 negative regulation of cardiac muscle cell proliferation 2/1096 21/18670 0.3517 0.5207 0.3532 RBP4/JARID2 2 BP GO:0060713 labyrinthine layer morphogenesis 2/1096 21/18670 0.3517 0.5207 0.3532 SPINT2/ST14 2 BP GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/1096 21/18670 0.3517 0.5207 0.3532 EGFR/BMP4 2 BP GO:0098743 cell aggregation 2/1096 21/18670 0.3517 0.5207 0.3532 THRA/MGP 2 BP GO:0140058 neuron projection arborization 2/1096 21/18670 0.3517 0.5207 0.3532 SEMA3A/ZNF365 2 BP GO:1902307 positive regulation of sodium ion transmembrane transport 2/1096 21/18670 0.3517 0.5207 0.3532 ANK3/FXYD1 2 BP GO:1902884 positive regulation of response to oxidative stress 2/1096 21/18670 0.3517 0.5207 0.3532 RGN/ACOX2 2 BP GO:1903392 negative regulation of adherens junction organization 2/1096 21/18670 0.3517 0.5207 0.3532 VEGFA/DLC1 2 BP GO:1903817 negative regulation of voltage-gated potassium channel activity 2/1096 21/18670 0.3517 0.5207 0.3532 ANK3/KCNAB1 2 BP GO:1904469 positive regulation of tumor necrosis factor secretion 2/1096 21/18670 0.3517 0.5207 0.3532 LPL/LILRA2 2 BP GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/1096 21/18670 0.3517 0.5207 0.3532 ADIPOQ/PRKG1 2 BP GO:2000316 regulation of T-helper 17 type immune response 2/1096 21/18670 0.3517 0.5207 0.3532 IL27RA/NLRP3 2 BP GO:2000380 regulation of mesoderm development 2/1096 21/18670 0.3517 0.5207 0.3532 FGFR1/BMPR1A 2 BP GO:0042472 inner ear morphogenesis 7/1096 98/18670 0.3527 0.5217 0.3539 SIX1/GATA3/ZIC1/FZD2/FGFR1/GATA2/ABR 7 BP GO:0042773 ATP synthesis coupled electron transport 7/1096 98/18670 0.3527 0.5217 0.3539 MECP2/PINK1/CCNB1/COX6A2/NDUFB7/NDUFV1/UQCRC1 7 BP GO:0048024 regulation of mRNA splicing, via spliceosome 7/1096 98/18670 0.3527 0.5217 0.3539 KHDRBS3/CIRBP/FAM172A/SAP18/JMJD6/SRSF8/SREK1 7 BP GO:0090090 negative regulation of canonical Wnt signaling pathway 12/1096 178/18670 0.3529 0.5219 0.354 FOXO1/WWTR1/TCF7L2/SFRP4/IGFBP6/RAPGEF1/IGFBP2/HDAC1/APOE/G3BP1/CDH2/SFRP1 12 BP GO:0008543 fibroblast growth factor receptor signaling pathway 8/1096 114/18670 0.3539 0.5233 0.3549 GATA3/SULF1/MAPK3/FGFR1/POLR2E/POLR2I/FGFR3/SPRY1 8 BP GO:0006361 transcription initiation from RNA polymerase I promoter 3/1096 36/18670 0.3548 0.5234 0.355 MAPK3/POLR2E/POLR1C 3 BP GO:0006699 bile acid biosynthetic process 3/1096 36/18670 0.3548 0.5234 0.355 CH25H/SLC27A2/ACOX2 3 BP GO:0033572 transferrin transport 3/1096 36/18670 0.3548 0.5234 0.355 ARHGAP1/TFRC/ATP6V0D1 3 BP GO:0034314 Arp2/3 complex-mediated actin nucleation 3/1096 36/18670 0.3548 0.5234 0.355 GMFG/NCKAP1/ARPC3 3 BP GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 3/1096 36/18670 0.3548 0.5234 0.355 GATA3/SULF1/SPRY1 3 BP GO:0042554 superoxide anion generation 3/1096 36/18670 0.3548 0.5234 0.355 EGFR/ITGB2/NCF2 3 BP GO:0050931 pigment cell differentiation 3/1096 36/18670 0.3548 0.5234 0.355 ENPP1/RAB27A/GNA11 3 BP GO:0051973 positive regulation of telomerase activity 3/1096 36/18670 0.3548 0.5234 0.355 PARM1/MAPK3/MAP3K4 3 BP GO:0090313 regulation of protein targeting to membrane 3/1096 36/18670 0.3548 0.5234 0.355 ANK3/PAK1/ITGB2 3 BP GO:0016050 vesicle organization 21/1096 325/18670 0.3564 0.5256 0.3565 SERPINE2/SRGN/CORO1A/TGFA/STXBP1/STX11/FNBP1L/TAP1/SERPINA1/SDC1/RAB27A/CTSC/DNM1/F2R/UNC13B/F8/TBC1D4/RAB22A/SNAP91/TAPBP/VAPA 21 BP GO:0015807 L-amino acid transport 5/1096 67/18670 0.3576 0.527 0.3574 SLC1A4/PRAF2/RGS2/SLC7A8/SLC7A5 5 BP GO:0046365 monosaccharide catabolic process 5/1096 67/18670 0.3576 0.527 0.3574 PFKM/HK2/LRP5/BAD/ALDOA 5 BP GO:0051298 centrosome duplication 5/1096 67/18670 0.3576 0.527 0.3574 ARHGEF10/PLK2/CETN2/SPICE1/STIL 5 BP GO:0072524 pyridine-containing compound metabolic process 13/1096 195/18670 0.3588 0.5285 0.3585 ZBTB20/NUPR1/NAMPT/PFKM/HK2/CD38/INSR/HIF1A/PGD/HDAC4/DDIT4/NUP210/ALDOA 13 BP GO:0033044 regulation of chromosome organization 22/1096 342/18670 0.3596 0.5296 0.3592 MECP2/VEGFA/HMGA1/GATA3/ATRX/IL1B/AUTS2/MAPK3/MAP3K4/PTTG1/GATA2/PAF1/ERCC1/PINK1/CCNB1/ZNHIT1/USP7/TADA3/JARID2/TWIST1/PLK1/CDC6 22 BP GO:0006611 protein export from nucleus 12/1096 179/18670 0.3601 0.5302 0.3596 EGR2/TCF7L2/IL1B/DDX39A/GAS6/SLBP/CDC40/PPM1A/CASC3/NXF1/NUP210/POLDIP3 12 BP GO:0008652 cellular amino acid biosynthetic process 6/1096 83/18670 0.3608 0.5309 0.3601 ASS1/GOT2/BCAT1/CDO1/ASPA/GOT1 6 BP GO:0060218 hematopoietic stem cell differentiation 6/1096 83/18670 0.3608 0.5309 0.3601 GATA3/MEOX1/BATF/GATA2/FOXC1/SFRP1 6 BP GO:0071277 cellular response to calcium ion 6/1096 83/18670 0.3608 0.5309 0.3601 CPNE1/HSPA5/SYT17/LGMN/JUN/ADCY1 6 BP GO:0051188 cofactor biosynthetic process 21/1096 326/18670 0.3617 0.532 0.3609 ZBTB20/NUPR1/NAMPT/PFKM/HK2/GCH1/RGN/TECR/PDK2/INSR/HIF1A/PCBD1/NFE2L1/ZNF205/PPOX/UROD/QDPR/HDAC4/DDIT4/NUP210/ALDOA 21 BP GO:1901570 fatty acid derivative biosynthetic process 7/1096 99/18670 0.3624 0.5329 0.3615 LTC4S/PTGS1/HPGDS/IL1B/TECR/PTGDS/ALOX5 7 BP GO:0009108 coenzyme biosynthetic process 17/1096 261/18670 0.3645 0.5354 0.3631 ZBTB20/NUPR1/NAMPT/PFKM/HK2/GCH1/RGN/TECR/PDK2/INSR/HIF1A/PCBD1/QDPR/HDAC4/DDIT4/NUP210/ALDOA 17 BP GO:0006998 nuclear envelope organization 4/1096 52/18670 0.3648 0.5354 0.3631 PRKCB/CCNB1/PLK1/CCNB2 4 BP GO:0030514 negative regulation of BMP signaling pathway 4/1096 52/18670 0.3648 0.5354 0.3631 HTRA1/SFRP1/PPM1A/SMAD6 4 BP GO:0032653 regulation of interleukin-10 production 4/1096 52/18670 0.3648 0.5354 0.3631 FCGR2B/TRIB2/CD83/TLR2 4 BP GO:0035176 social behavior 4/1096 52/18670 0.3648 0.5354 0.3631 MECP2/SHANK2/CX3CR1/VPS13A 4 BP GO:0048168 regulation of neuronal synaptic plasticity 4/1096 52/18670 0.3648 0.5354 0.3631 EGR2/SYNGR1/UNC13B/APOE 4 BP GO:0051703 intraspecies interaction between organisms 4/1096 52/18670 0.3648 0.5354 0.3631 MECP2/SHANK2/CX3CR1/VPS13A 4 BP GO:2000649 regulation of sodium ion transmembrane transporter activity 4/1096 52/18670 0.3648 0.5354 0.3631 ANK3/FXYD1/NEDD4L/CAV3 4 BP GO:0006625 protein targeting to peroxisome 5/1096 68/18670 0.3694 0.5413 0.3672 ECH1/CRAT/PEX19/SLC27A2/ACOX2 5 BP GO:0033047 regulation of mitotic sister chromatid segregation 5/1096 68/18670 0.3694 0.5413 0.3672 ATRX/PTTG1/CCNB1/PLK1/CDC6 5 BP GO:0046323 glucose import 5/1096 68/18670 0.3694 0.5413 0.3672 ADIPOQ/ENPP1/ADIPOR2/HK2/INSR 5 BP GO:0051965 positive regulation of synapse assembly 5/1096 68/18670 0.3694 0.5413 0.3672 CLSTN1/NTRK3/THBS2/DLG5/EFNA5 5 BP GO:0072662 protein localization to peroxisome 5/1096 68/18670 0.3694 0.5413 0.3672 ECH1/CRAT/PEX19/SLC27A2/ACOX2 5 BP GO:0072663 establishment of protein localization to peroxisome 5/1096 68/18670 0.3694 0.5413 0.3672 ECH1/CRAT/PEX19/SLC27A2/ACOX2 5 BP GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/1096 37/18670 0.3712 0.5421 0.3677 BTG2/CNOT1/CNOT4 3 BP GO:0001662 behavioral fear response 3/1096 37/18670 0.3712 0.5421 0.3677 MECP2/USP46/APOE 3 BP GO:0006270 DNA replication initiation 3/1096 37/18670 0.3712 0.5421 0.3677 PURA/PRIM2/CDC6 3 BP GO:0021587 cerebellum morphogenesis 3/1096 37/18670 0.3712 0.5421 0.3677 SERPINE2/ZNF365/HSPA5 3 BP GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/1096 37/18670 0.3712 0.5421 0.3677 CDH5/CAMSAP2/STMN2 3 BP GO:0042307 positive regulation of protein import into nucleus 3/1096 37/18670 0.3712 0.5421 0.3677 SMAD3/ZIC1/HCLS1 3 BP GO:0051084 'de novo' posttranslational protein folding 3/1096 37/18670 0.3712 0.5421 0.3677 DNAJB5/BAG1/HSPA5 3 BP GO:0060323 head morphogenesis 3/1096 37/18670 0.3712 0.5421 0.3677 ASPH/COL1A1/PDGFRA 3 BP GO:0071542 dopaminergic neuron differentiation 3/1096 37/18670 0.3712 0.5421 0.3677 VEGFA/HIF1A/SFRP1 3 BP GO:1903427 negative regulation of reactive oxygen species biosynthetic process 3/1096 37/18670 0.3712 0.5421 0.3677 RGN/TRAP1/SLC18A2 3 BP GO:0010507 negative regulation of autophagy 6/1096 84/18670 0.3715 0.5421 0.3677 NUPR1/NAMPT/DAP/NPC1/PTPN22/PINK1 6 BP GO:0006304 DNA modification 8/1096 116/18670 0.3719 0.5421 0.3677 FTO/MECP2/GATA3/ATRX/PARP3/EHMT2/USP7/MBD2 8 BP GO:2000736 regulation of stem cell differentiation 8/1096 116/18670 0.3719 0.5421 0.3677 SOX5/TGFB2/GATA3/GATA2/SEMA3C/BMP4/FOXC1/PDGFRA 8 BP GO:0007215 glutamate receptor signaling pathway 7/1096 100/18670 0.3721 0.5421 0.3677 PLCB1/PTK2B/SHANK2/CCR2/PINK1/HOMER3/CCL2 7 BP GO:2001023 regulation of response to drug 7/1096 100/18670 0.3721 0.5421 0.3677 ADIRF/RGS2/TRAP1/SYT17/PINK1/SNCG/CXCL12 7 BP GO:0005980 glycogen catabolic process 2/1096 22/18670 0.3733 0.5421 0.3677 PYGM/PYGB 2 BP GO:0006379 mRNA cleavage 2/1096 22/18670 0.3733 0.5421 0.3677 RNASE4/POLR2I 2 BP GO:0010866 regulation of triglyceride biosynthetic process 2/1096 22/18670 0.3733 0.5421 0.3677 SIK1/RGN 2 BP GO:0019883 antigen processing and presentation of endogenous antigen 2/1096 22/18670 0.3733 0.5421 0.3677 TAP1/TAPBP 2 BP GO:0021854 hypothalamus development 2/1096 22/18670 0.3733 0.5421 0.3677 SEMA3A/NRP2 2 BP GO:0031281 positive regulation of cyclase activity 2/1096 22/18670 0.3733 0.5421 0.3677 MAPK3/TIMP2 2 BP GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 2/1096 22/18670 0.3733 0.5421 0.3677 STXBP1/STX11 2 BP GO:0032069 regulation of nuclease activity 2/1096 22/18670 0.3733 0.5421 0.3677 GZMA/OAS2 2 BP GO:0032402 melanosome transport 2/1096 22/18670 0.3733 0.5421 0.3677 RAB27A/DCTN2 2 BP GO:0032727 positive regulation of interferon-alpha production 2/1096 22/18670 0.3733 0.5421 0.3677 STAT1/IRF7 2 BP GO:0032928 regulation of superoxide anion generation 2/1096 22/18670 0.3733 0.5421 0.3677 EGFR/ITGB2 2 BP GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/1096 22/18670 0.3733 0.5421 0.3677 HIF1A/UCHL1 2 BP GO:0035584 calcium-mediated signaling using intracellular calcium source 2/1096 22/18670 0.3733 0.5421 0.3677 PTPRC/SELP 2 BP GO:0036119 response to platelet-derived growth factor 2/1096 22/18670 0.3733 0.5421 0.3677 CCNA2/HYAL1 2 BP GO:0045723 positive regulation of fatty acid biosynthetic process 2/1096 22/18670 0.3733 0.5421 0.3677 IL1B/RGN 2 BP GO:0047497 mitochondrion transport along microtubule 2/1096 22/18670 0.3733 0.5421 0.3677 HIF1A/UCHL1 2 BP GO:0060575 intestinal epithelial cell differentiation 2/1096 22/18670 0.3733 0.5421 0.3677 HOXA5/HIF1A 2 BP GO:0090312 positive regulation of protein deacetylation 2/1096 22/18670 0.3733 0.5421 0.3677 VEGFA/PINK1 2 BP GO:0140112 extracellular vesicle biogenesis 2/1096 22/18670 0.3733 0.5421 0.3677 SDC1/RAB27A 2 BP GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/1096 22/18670 0.3733 0.5421 0.3677 PARP3/TFIP11 2 BP GO:0006403 RNA localization 15/1096 230/18670 0.3749 0.5443 0.3692 RFTN1/DDX39A/UPF3A/PURA/SLBP/MX2/FBL/CETN2/IGF2BP3/CDC40/TST/CASC3/NXF1/NUP210/POLDIP3 15 BP GO:0050954 sensory perception of mechanical stimulus 11/1096 165/18670 0.3763 0.5462 0.3705 SERPINE2/CXCR4/SIX1/ICAM1/CLIC5/COL1A1/FGFR1/GPX1/CXCL12/CRYM/WFS1 11 BP GO:0015893 drug transport 14/1096 214/18670 0.3772 0.5473 0.3712 NFKBIE/HBB/PRAF2/RGS2/SLC7A5/MB/SYT17/PINK1/AQP1/SNCG/SLC25A4/CXCL12/HBE1/SLC18A2 14 BP GO:0032984 protein-containing complex disassembly 21/1096 329/18670 0.3777 0.5479 0.3716 TMOD1/SEMA5A/GSN/HMGA1/PLEK/FZD2/SPTBN1/ASPH/INSR/GABARAPL1/CAPG/SMARCD3/CAMSAP2/MRPS18B/GSPT1/SCAF8/STMN2/DDIT4/MRPL49/BNIP3/TFIP11 21 BP GO:0021879 forebrain neuron differentiation 4/1096 53/18670 0.3784 0.5482 0.3719 SEMA3A/GATA2/NRP2/ATF5 4 BP GO:0031122 cytoplasmic microtubule organization 4/1096 53/18670 0.3784 0.5482 0.3719 DST/CAV3/CAMSAP2/TUBGCP4 4 BP GO:0043331 response to dsRNA 4/1096 53/18670 0.3784 0.5482 0.3719 RFTN1/MAPK3/NFKBIA/NFKB1 4 BP GO:0060563 neuroepithelial cell differentiation 4/1096 53/18670 0.3784 0.5482 0.3719 FGFR1/B9D1/SERPINE1/CDH2 4 BP GO:1902475 L-alpha-amino acid transmembrane transport 4/1096 53/18670 0.3784 0.5482 0.3719 PRAF2/RGS2/SLC7A8/SLC7A5 4 BP GO:0046890 regulation of lipid biosynthetic process 13/1096 198/18670 0.3794 0.5496 0.3728 ZBTB20/ADIPOQ/IL1B/ADIPOR2/IGFBP7/SIK1/RGN/NFKB1/ABCG1/APOC1/CDK4/PMVK/APOE 13 BP GO:0001508 action potential 9/1096 133/18670 0.3796 0.5496 0.3728 ANK3/NTRK3/BIN1/NEDD4L/GNA11/KCNJ8/CAV3/AKAP9/SNTA1 9 BP GO:0031023 microtubule organizing center organization 9/1096 133/18670 0.3796 0.5496 0.3728 ARL2/ARHGEF10/KIF3B/PLK2/CETN2/PLK1/SPICE1/STIL/ATF5 9 BP GO:0030166 proteoglycan biosynthetic process 5/1096 69/18670 0.3813 0.5516 0.3741 UST/XYLT1/TCF7L2/CHST3/UGDH 5 BP GO:0036465 synaptic vesicle recycling 5/1096 69/18670 0.3813 0.5516 0.3741 DNM1/SYT17/SNAP91/KIAA1109/PPP3CC 5 BP GO:0043574 peroxisomal transport 5/1096 69/18670 0.3813 0.5516 0.3741 ECH1/CRAT/PEX19/SLC27A2/ACOX2 5 BP GO:0050830 defense response to Gram-positive bacterium 7/1096 101/18670 0.3819 0.5521 0.3745 RARRES2/IL27RA/MYD88/GBP2/TLR2/LBP/NLRP3 7 BP GO:1903008 organelle disassembly 7/1096 101/18670 0.3819 0.5521 0.3745 HK2/GABARAPL1/HIF1A/PINK1/CTTN/WDR45/BNIP3 7 BP GO:0002209 behavioral defense response 3/1096 38/18670 0.3874 0.559 0.3791 MECP2/USP46/APOE 3 BP GO:0007223 Wnt signaling pathway, calcium modulating pathway 3/1096 38/18670 0.3874 0.559 0.3791 PLCB1/TCF7L2/FZD2 3 BP GO:0010667 negative regulation of cardiac muscle cell apoptotic process 3/1096 38/18670 0.3874 0.559 0.3791 NUPR1/NOL3/HSPB6 3 BP GO:0015682 ferric iron transport 3/1096 38/18670 0.3874 0.559 0.3791 ARHGAP1/TFRC/ATP6V0D1 3 BP GO:0046326 positive regulation of glucose import 3/1096 38/18670 0.3874 0.559 0.3791 ADIPOQ/ADIPOR2/INSR 3 BP GO:0046676 negative regulation of insulin secretion 3/1096 38/18670 0.3874 0.559 0.3791 HADH/SFRP1/INHBB 3 BP GO:0072512 trivalent inorganic cation transport 3/1096 38/18670 0.3874 0.559 0.3791 ARHGAP1/TFRC/ATP6V0D1 3 BP GO:2000279 negative regulation of DNA biosynthetic process 3/1096 38/18670 0.3874 0.559 0.3791 ADIPOQ/RGN/PARP3 3 BP GO:0021953 central nervous system neuron differentiation 12/1096 183/18670 0.3889 0.561 0.3805 GABRB1/SEMA3A/NFIB/DCLK1/BTG2/HPRT1/GATA2/ID4/NFE2L1/SFRP1/NRP2/ATF5 12 BP GO:0002763 positive regulation of myeloid leukocyte differentiation 4/1096 54/18670 0.3919 0.5647 0.383 HCLS1/PF4/CTNNBIP1/JUN 4 BP GO:0010524 positive regulation of calcium ion transport into cytosol 4/1096 54/18670 0.3919 0.5647 0.383 P2RY6/F2R/THY1/CXCL10 4 BP GO:0045747 positive regulation of Notch signaling pathway 4/1096 54/18670 0.3919 0.5647 0.383 TSPAN5/TGFB2/LFNG/ZMIZ1 4 BP GO:0003333 amino acid transmembrane transport 6/1096 86/18670 0.3928 0.5647 0.383 SLC1A4/PRAF2/RGS2/PDPN/SLC7A8/SLC7A5 6 BP GO:0006303 double-strand break repair via nonhomologous end joining 6/1096 86/18670 0.3928 0.5647 0.383 MDC1/TP53BP1/ERCC1/PARP3/KAT5/TFIP11 6 BP GO:0042446 hormone biosynthetic process 6/1096 86/18670 0.3928 0.5647 0.383 IL1B/AKR1B1/NFKB1/HIF1A/DIO3/HSD11B2 6 BP GO:0070988 demethylation 5/1096 70/18670 0.3931 0.5647 0.383 FTO/GATA3/JMJD6/USP7/JARID2 5 BP GO:0002347 response to tumor cell 2/1096 23/18670 0.3946 0.5647 0.383 CD226/CRTAM 2 BP GO:0006359 regulation of transcription by RNA polymerase III 2/1096 23/18670 0.3946 0.5647 0.383 AR/TENM1 2 BP GO:0009067 aspartate family amino acid biosynthetic process 2/1096 23/18670 0.3946 0.5647 0.383 GOT2/GOT1 2 BP GO:0009251 glucan catabolic process 2/1096 23/18670 0.3946 0.5647 0.383 PYGM/PYGB 2 BP GO:0010447 response to acidic pH 2/1096 23/18670 0.3946 0.5647 0.383 PCK1/LGMN 2 BP GO:0032401 establishment of melanosome localization 2/1096 23/18670 0.3946 0.5647 0.383 RAB27A/DCTN2 2 BP GO:0032717 negative regulation of interleukin-8 production 2/1096 23/18670 0.3946 0.5647 0.383 PTPN22/ELANE 2 BP GO:0035812 renal sodium excretion 2/1096 23/18670 0.3946 0.5647 0.383 ADORA1/AGTR1 2 BP GO:0042401 cellular biogenic amine biosynthetic process 2/1096 23/18670 0.3946 0.5647 0.383 HDC/MOXD1 2 BP GO:0051350 negative regulation of lyase activity 2/1096 23/18670 0.3946 0.5647 0.383 CCR2/AKAP9 2 BP GO:0051882 mitochondrial depolarization 2/1096 23/18670 0.3946 0.5647 0.383 GOT1/MLLT11 2 BP GO:0051904 pigment granule transport 2/1096 23/18670 0.3946 0.5647 0.383 RAB27A/DCTN2 2 BP GO:0070977 bone maturation 2/1096 23/18670 0.3946 0.5647 0.383 XYLT1/FGFR3 2 BP GO:0072170 metanephric tubule development 2/1096 23/18670 0.3946 0.5647 0.383 WWTR1/STAT1 2 BP GO:0086012 membrane depolarization during cardiac muscle cell action potential 2/1096 23/18670 0.3946 0.5647 0.383 ANK3/CAV3 2 BP GO:0090140 regulation of mitochondrial fission 2/1096 23/18670 0.3946 0.5647 0.383 PINK1/BNIP3 2 BP GO:0099500 vesicle fusion to plasma membrane 2/1096 23/18670 0.3946 0.5647 0.383 STXBP1/STX11 2 BP GO:1900746 regulation of vascular endothelial growth factor signaling pathway 2/1096 23/18670 0.3946 0.5647 0.383 ADAMTS3/PTP4A3 2 BP GO:1901032 negative regulation of response to reactive oxygen species 2/1096 23/18670 0.3946 0.5647 0.383 TRAP1/PINK1 2 BP GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/1096 23/18670 0.3946 0.5647 0.383 CD44/PTTG1IP 2 BP GO:1902259 regulation of delayed rectifier potassium channel activity 2/1096 23/18670 0.3946 0.5647 0.383 ANK3/KCNAB1 2 BP GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/1096 23/18670 0.3946 0.5647 0.383 TRAP1/PINK1 2 BP GO:2000050 regulation of non-canonical Wnt signaling pathway 2/1096 23/18670 0.3946 0.5647 0.383 SFRP4/SFRP1 2 BP GO:2000637 positive regulation of gene silencing by miRNA 2/1096 23/18670 0.3946 0.5647 0.383 EGFR/BMP4 2 BP GO:2001039 negative regulation of cellular response to drug 2/1096 23/18670 0.3946 0.5647 0.383 TRAP1/PINK1 2 BP GO:0034728 nucleosome organization 12/1096 184/18670 0.3961 0.5667 0.3844 NAP1L3/HMGA1/KAT6B/TSPYL4/ATRX/SMARCA1/DAXX/PAF1/SMARCD3/ZNHIT1/TSPYL2/TNP2 12 BP GO:0016079 synaptic vesicle exocytosis 8/1096 119/18670 0.399 0.5706 0.387 STXBP1/STX11/PRKCB/SYT17/UNC13B/RIMS3/PFN2/ADCY1 8 BP GO:0015849 organic acid transport 21/1096 333/18670 0.3992 0.5706 0.387 NFKBIE/ABCC3/FABP4/STXBP1/IL1B/ADORA1/SLC1A4/PRAF2/SLC23A2/GOT2/NMB/RGS2/PDPN/AQP9/SLC7A8/SLC27A2/SLC7A5/UNC13B/NFE2L1/APOE/RXRA 21 BP GO:0046942 carboxylic acid transport 21/1096 333/18670 0.3992 0.5706 0.387 NFKBIE/ABCC3/FABP4/STXBP1/IL1B/ADORA1/SLC1A4/PRAF2/SLC23A2/GOT2/NMB/RGS2/PDPN/AQP9/SLC7A8/SLC27A2/SLC7A5/UNC13B/NFE2L1/APOE/RXRA 21 BP GO:0001892 embryonic placenta development 6/1096 87/18670 0.4034 0.5763 0.3909 EGFR/GATA2/HIF1A/PHLDA2/SPINT2/ST14 6 BP GO:0051930 regulation of sensory perception of pain 3/1096 39/18670 0.4035 0.5763 0.3909 ADORA1/PTAFR/F2R 3 BP GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/1096 39/18670 0.4035 0.5763 0.3909 CD44/NACC2/CXCL12 3 BP GO:2000816 negative regulation of mitotic sister chromatid separation 3/1096 39/18670 0.4035 0.5763 0.3909 PTTG1/CCNB1/PLK1 3 BP GO:0050795 regulation of behavior 5/1096 71/18670 0.4049 0.578 0.392 ADA/ADORA1/APOE/HDAC4/PTGDS 5 BP GO:0045814 negative regulation of gene expression, epigenetic 9/1096 136/18670 0.405 0.578 0.392 EZH1/MECP2/HMGA1/PCGF2/FAM172A/HDAC1/MSL3/JARID2/MBD2 9 BP GO:0006383 transcription by RNA polymerase III 4/1096 55/18670 0.4054 0.578 0.392 AR/POLR2E/POLR1C/TENM1 4 BP GO:0006576 cellular biogenic amine metabolic process 4/1096 55/18670 0.4054 0.578 0.392 MAOA/MECP2/HDC/MOXD1 4 BP GO:0010823 negative regulation of mitochondrion organization 4/1096 55/18670 0.4054 0.578 0.392 NOL3/PINK1/GPX1/BNIP3 4 BP GO:0032613 interleukin-10 production 4/1096 55/18670 0.4054 0.578 0.392 FCGR2B/TRIB2/CD83/TLR2 4 BP GO:0098900 regulation of action potential 4/1096 55/18670 0.4054 0.578 0.392 ANK3/BIN1/CAV3/AKAP9 4 BP GO:0042391 regulation of membrane potential 27/1096 434/18670 0.4056 0.5781 0.3921 GABRB1/MECP2/ANK3/NTRK3/BIN1/PTK2B/SHANK2/FXYD1/ADORA1/NEDD4L/PLN/GNA11/KCNJ8/CASQ2/CAV3/AKAP9/PINK1/GOT1/UNC13B/SNTA1/BAD/GLRB/RIMS3/MLLT11/BNIP3/FHL1/JUN 27 BP GO:0006342 chromatin silencing 8/1096 120/18670 0.4081 0.5814 0.3944 EZH1/MECP2/HMGA1/PCGF2/FAM172A/HDAC1/MSL3/MBD2 8 BP GO:0006892 post-Golgi vesicle-mediated transport 7/1096 104/18670 0.4111 0.5852 0.3969 ANK3/SPTBN1/MYO1B/VPS13A/CSK/ARF3/LYPLA1 7 BP GO:0010923 negative regulation of phosphatase activity 7/1096 104/18670 0.4111 0.5852 0.3969 TGFB2/RGN/MGAT5/PPP1R2/NCKAP1L/PPP1R1A/RIMBP2 7 BP GO:0046928 regulation of neurotransmitter secretion 7/1096 104/18670 0.4111 0.5852 0.3969 STXBP1/PRKCB/UNC13B/SNCG/RIMS3/PFN2/ADCY1 7 BP GO:1901800 positive regulation of proteasomal protein catabolic process 7/1096 104/18670 0.4111 0.5852 0.3969 NUPR1/RNF144A/TRIB2/PLK2/PLK1/USP5/HERPUD1 7 BP GO:0009100 glycoprotein metabolic process 26/1096 419/18670 0.4136 0.5874 0.3984 UST/PLCB1/GALNT10/XYLT1/SPOCK2/HBEGF/TCF7L2/SULF1/CCR7/MAN2B2/NPC1/GFPT1/B4GALT2/MGAT5/RNF103/HIF1A/CHST3/LFNG/MPI/UBE2J1/HEXA/APCS/GANAB/UGDH/HYAL1/IL15 26 BP GO:0050829 defense response to Gram-negative bacterium 6/1096 88/18670 0.414 0.5874 0.3984 RARRES2/CXCL6/SERPINE1/LBP/SELP/ELANE 6 BP GO:1903725 regulation of phospholipid metabolic process 6/1096 88/18670 0.414 0.5874 0.3984 PTK2B/CCR7/APOC1/FGFR3/PDGFRA/FLT1 6 BP GO:0001919 regulation of receptor recycling 2/1096 24/18670 0.4155 0.5874 0.3984 RAB29/INPP5F 2 BP GO:0003272 endocardial cushion formation 2/1096 24/18670 0.4155 0.5874 0.3984 TGFB2/BMPR1A 2 BP GO:0007097 nuclear migration 2/1096 24/18670 0.4155 0.5874 0.3984 MYH10/TRIM58 2 BP GO:0009309 amine biosynthetic process 2/1096 24/18670 0.4155 0.5874 0.3984 HDC/MOXD1 2 BP GO:0010288 response to lead ion 2/1096 24/18670 0.4155 0.5874 0.3984 CDK4/QDPR 2 BP GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/1096 24/18670 0.4155 0.5874 0.3984 PLN/CASQ2 2 BP GO:0021895 cerebral cortex neuron differentiation 2/1096 24/18670 0.4155 0.5874 0.3984 HPRT1/ID4 2 BP GO:0034162 toll-like receptor 9 signaling pathway 2/1096 24/18670 0.4155 0.5874 0.3984 MYD88/GRAMD4 2 BP GO:0036315 cellular response to sterol 2/1096 24/18670 0.4155 0.5874 0.3984 DAG1/NFE2L1 2 BP GO:0042104 positive regulation of activated T cell proliferation 2/1096 24/18670 0.4155 0.5874 0.3984 IGFBP2/IL2RA 2 BP GO:0045603 positive regulation of endothelial cell differentiation 2/1096 24/18670 0.4155 0.5874 0.3984 CDH5/BMP4 2 BP GO:0046174 polyol catabolic process 2/1096 24/18670 0.4155 0.5874 0.3984 GK/NUDT3 2 BP GO:0046426 negative regulation of JAK-STAT cascade 2/1096 24/18670 0.4155 0.5874 0.3984 INPP5F/PTPN2 2 BP GO:0046639 negative regulation of alpha-beta T cell differentiation 2/1096 24/18670 0.4155 0.5874 0.3984 RUNX3/IL4R 2 BP GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/1096 24/18670 0.4155 0.5874 0.3984 ENPP1/PAPSS2 2 BP GO:0051905 establishment of pigment granule localization 2/1096 24/18670 0.4155 0.5874 0.3984 RAB27A/DCTN2 2 BP GO:0060148 positive regulation of posttranscriptional gene silencing 2/1096 24/18670 0.4155 0.5874 0.3984 EGFR/BMP4 2 BP GO:0090103 cochlea morphogenesis 2/1096 24/18670 0.4155 0.5874 0.3984 SIX1/FZD2 2 BP GO:0099563 modification of synaptic structure 2/1096 24/18670 0.4155 0.5874 0.3984 MYH10/PFN2 2 BP GO:0099590 neurotransmitter receptor internalization 2/1096 24/18670 0.4155 0.5874 0.3984 DNM1/USP46 2 BP GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 2/1096 24/18670 0.4155 0.5874 0.3984 ADAMTS3/PTP4A3 2 BP GO:1903010 regulation of bone development 2/1096 24/18670 0.4155 0.5874 0.3984 RGN/CARM1 2 BP GO:1903421 regulation of synaptic vesicle recycling 2/1096 24/18670 0.4155 0.5874 0.3984 DNM1/PPP3CC 2 BP GO:1903649 regulation of cytoplasmic transport 2/1096 24/18670 0.4155 0.5874 0.3984 MAPK3/RAB29 2 BP GO:2000209 regulation of anoikis 2/1096 24/18670 0.4155 0.5874 0.3984 SIK1/ITGA5 2 BP GO:0035019 somatic stem cell population maintenance 5/1096 72/18670 0.4167 0.5886 0.3992 GATA2/POLR2E/POLR2I/SFRP1/CUL4A 5 BP GO:0051881 regulation of mitochondrial membrane potential 5/1096 72/18670 0.4167 0.5886 0.3992 PINK1/GOT1/BAD/MLLT11/BNIP3 5 BP GO:0090114 COPII-coated vesicle budding 5/1096 72/18670 0.4167 0.5886 0.3992 TGFA/SERPINA1/CTSC/F8/VAPA 5 BP GO:0009435 NAD biosynthetic process 4/1096 56/18670 0.4188 0.591 0.4008 NAMPT/PFKM/HK2/ALDOA 4 BP GO:0098586 cellular response to virus 4/1096 56/18670 0.4188 0.591 0.4008 BIRC3/BAD/IRF7/IKBKE 4 BP GO:1903078 positive regulation of protein localization to plasma membrane 4/1096 56/18670 0.4188 0.591 0.4008 EPHA3/EGFR/SPTBN1/PRKCH 4 BP GO:0001709 cell fate determination 3/1096 40/18670 0.4195 0.591 0.4008 GATA3/GATA2/BMP4 3 BP GO:0006734 NADH metabolic process 3/1096 40/18670 0.4195 0.591 0.4008 PFKM/HK2/ALDOA 3 BP GO:0042596 fear response 3/1096 40/18670 0.4195 0.591 0.4008 MECP2/USP46/APOE 3 BP GO:0051931 regulation of sensory perception 3/1096 40/18670 0.4195 0.591 0.4008 ADORA1/PTAFR/F2R 3 BP GO:0090207 regulation of triglyceride metabolic process 3/1096 40/18670 0.4195 0.591 0.4008 SIK1/RGN/APOE 3 BP GO:0098760 response to interleukin-7 3/1096 40/18670 0.4195 0.591 0.4008 IL2RG/IL7R/RAD23B 3 BP GO:0098761 cellular response to interleukin-7 3/1096 40/18670 0.4195 0.591 0.4008 IL2RG/IL7R/RAD23B 3 BP GO:1905819 negative regulation of chromosome separation 3/1096 40/18670 0.4195 0.591 0.4008 PTTG1/CCNB1/PLK1 3 BP GO:0032006 regulation of TOR signaling 7/1096 105/18670 0.4208 0.5926 0.402 AKT3/SIK1/GAS6/HIF1A/FBXO9/DDIT4/NPRL3 7 BP GO:0006282 regulation of DNA repair 8/1096 122/18670 0.4261 0.6 0.4069 EGFR/ZNF365/TP53BP1/PARP3/TWIST1/FAM168A/CUL4A/TFIP11 8 BP GO:0000281 mitotic cytokinesis 5/1096 73/18670 0.4285 0.6028 0.4089 ANK3/SPTBN1/MYH10/PLK1/JTB 5 BP GO:0006283 transcription-coupled nucleotide-excision repair 5/1096 73/18670 0.4285 0.6028 0.4089 ERCC1/POLR2E/USP7/POLR2I/CUL4A 5 BP GO:0033555 multicellular organismal response to stress 5/1096 73/18670 0.4285 0.6028 0.4089 MECP2/GCH1/USP46/APOE/THBS4 5 BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 9/1096 139/18670 0.4304 0.6055 0.4107 ADCY9/PLN/PTHLH/ADCY6/PF4/CXCL10/PTGER2/S1PR4/ADCY1 9 BP GO:0010665 regulation of cardiac muscle cell apoptotic process 4/1096 57/18670 0.4322 0.6073 0.4119 NUPR1/NOL3/HSPB6/BNIP3 4 BP GO:0010965 regulation of mitotic sister chromatid separation 4/1096 57/18670 0.4322 0.6073 0.4119 PTTG1/CCNB1/PLK1/CDC6 4 BP GO:0051055 negative regulation of lipid biosynthetic process 4/1096 57/18670 0.4322 0.6073 0.4119 SIK1/NFKB1/APOC1/APOE 4 BP GO:1901799 negative regulation of proteasomal protein catabolic process 4/1096 57/18670 0.4322 0.6073 0.4119 LAMP3/CAMLG/UBE2J1/USP7 4 BP GO:0045216 cell-cell junction organization 10/1096 156/18670 0.434 0.6085 0.4127 ARL2/TGFB2/SMAD3/TLN2/CDH5/DLG5/F2R/PECAM1/PRKCH/CDH2 10 BP GO:0015844 monoamine transport 6/1096 90/18670 0.4352 0.6085 0.4127 MECP2/SYT17/PINK1/SNCG/CXCL12/SLC18A2 6 BP GO:0030901 midbrain development 6/1096 90/18670 0.4352 0.6085 0.4127 HSPA5/SMAD1/FGFR1/DLG5/BASP1/SFRP1 6 BP GO:0006308 DNA catabolic process 3/1096 41/18670 0.4354 0.6085 0.4127 RGN/DNASE1L3/ISG20 3 BP GO:0006458 'de novo' protein folding 3/1096 41/18670 0.4354 0.6085 0.4127 DNAJB5/BAG1/HSPA5 3 BP GO:0010664 negative regulation of striated muscle cell apoptotic process 3/1096 41/18670 0.4354 0.6085 0.4127 NUPR1/NOL3/HSPB6 3 BP GO:0045616 regulation of keratinocyte differentiation 3/1096 41/18670 0.4354 0.6085 0.4127 CTSL/PRKCH/FOXC1 3 BP GO:0050798 activated T cell proliferation 3/1096 41/18670 0.4354 0.6085 0.4127 IGFBP2/SATB1/IL2RA 3 BP GO:0070317 negative regulation of G0 to G1 transition 3/1096 41/18670 0.4354 0.6085 0.4127 PCGF2/EHMT2/RING1 3 BP GO:0098927 vesicle-mediated transport between endosomal compartments 3/1096 41/18670 0.4354 0.6085 0.4127 CORO1A/EMP2/MAPK3 3 BP GO:1903170 negative regulation of calcium ion transmembrane transport 3/1096 41/18670 0.4354 0.6085 0.4127 BIN1/PLN/CASQ2 3 BP GO:0002068 glandular epithelial cell development 2/1096 25/18670 0.4361 0.6085 0.4127 BMP4/BAD 2 BP GO:0002719 negative regulation of cytokine production involved in immune response 2/1096 25/18670 0.4361 0.6085 0.4127 ANGPT1/TGFB2 2 BP GO:0003309 type B pancreatic cell differentiation 2/1096 25/18670 0.4361 0.6085 0.4127 BMP4/BAD 2 BP GO:0007026 negative regulation of microtubule depolymerization 2/1096 25/18670 0.4361 0.6085 0.4127 CAMSAP2/STMN2 2 BP GO:0008211 glucocorticoid metabolic process 2/1096 25/18670 0.4361 0.6085 0.4127 MECP2/HSD11B2 2 BP GO:0021952 central nervous system projection neuron axonogenesis 2/1096 25/18670 0.4361 0.6085 0.4127 NFIB/DCLK1 2 BP GO:0031069 hair follicle morphogenesis 2/1096 25/18670 0.4361 0.6085 0.4127 TGFB2/IGFBP5 2 BP GO:0031639 plasminogen activation 2/1096 25/18670 0.4361 0.6085 0.4127 SERPINE2/SERPINE1 2 BP GO:0032400 melanosome localization 2/1096 25/18670 0.4361 0.6085 0.4127 RAB27A/DCTN2 2 BP GO:0033522 histone H2A ubiquitination 2/1096 25/18670 0.4361 0.6085 0.4127 PCGF2/RING1 2 BP GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/1096 25/18670 0.4361 0.6085 0.4127 ENPP1/PAPSS2 2 BP GO:0045956 positive regulation of calcium ion-dependent exocytosis 2/1096 25/18670 0.4361 0.6085 0.4127 STXBP1/UNC13B 2 BP GO:0046856 phosphatidylinositol dephosphorylation 2/1096 25/18670 0.4361 0.6085 0.4127 INPP5F/INPP5D 2 BP GO:0051654 establishment of mitochondrion localization 2/1096 25/18670 0.4361 0.6085 0.4127 HIF1A/UCHL1 2 BP GO:0060330 regulation of response to interferon-gamma 2/1096 25/18670 0.4361 0.6085 0.4127 STAT1/PTPN2 2 BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/1096 25/18670 0.4361 0.6085 0.4127 STAT1/PTPN2 2 BP GO:0072273 metanephric nephron morphogenesis 2/1096 25/18670 0.4361 0.6085 0.4127 BMP4/STAT1 2 BP GO:1904861 excitatory synapse assembly 2/1096 25/18670 0.4361 0.6085 0.4127 NTRK3/SHANK2 2 BP GO:0051145 smooth muscle cell differentiation 5/1096 74/18670 0.4402 0.6138 0.4163 MECP2/VEGFA/SIX1/SMARCD3/BMP4 5 BP GO:1900006 positive regulation of dendrite development 5/1096 74/18670 0.4402 0.6138 0.4163 CUX1/SHANK2/DLG5/APOE/COBL 5 BP GO:0006643 membrane lipid metabolic process 13/1096 207/18670 0.4419 0.616 0.4178 UGCG/TECR/ESYT1/GPAA1/ALDH5A1/PGAP2/ALDH3B1/HEXA/ALDH3A2/PLA2G15/STS/VAPA/NAGA 13 BP GO:0006733 oxidoreduction coenzyme metabolic process 13/1096 207/18670 0.4419 0.616 0.4178 ZBTB20/NUPR1/NAMPT/PFKM/HK2/CD38/INSR/HIF1A/PGD/HDAC4/DDIT4/NUP210/ALDOA 13 BP GO:0019218 regulation of steroid metabolic process 8/1096 124/18670 0.4442 0.6163 0.418 IL1B/IGFBP7/NFKB1/ABCG1/APOC1/PMVK/APOE/AGTR1 8 BP GO:0046488 phosphatidylinositol metabolic process 11/1096 174/18670 0.4446 0.6163 0.418 PLCB1/PTPN13/PIP4K2B/PLEK/PLCG2/SH3YL1/GPAA1/INPP5F/PGAP2/ARF3/INPP5D 11 BP GO:0046605 regulation of centrosome cycle 4/1096 58/18670 0.4455 0.6163 0.418 PLK2/SPICE1/STIL/ATF5 4 BP GO:0060997 dendritic spine morphogenesis 4/1096 58/18670 0.4455 0.6163 0.418 SIPA1L1/ZNF365/SHANK2/PDLIM5 4 BP GO:0061951 establishment of protein localization to plasma membrane 4/1096 58/18670 0.4455 0.6163 0.418 ANK3/SPTBN1/CSK/LYPLA1 4 BP GO:0006821 chloride transport 7/1096 108/18670 0.4499 0.6163 0.418 GABRB1/P2RY6/CLIC5/FXYD1/SLC1A4/PTAFR/GLRB 7 BP GO:0015696 ammonium transport 7/1096 108/18670 0.4499 0.6163 0.418 ADA/SYT17/PINK1/AQP1/SNCG/CXCL12/SLC18A2 7 BP GO:2000278 regulation of DNA biosynthetic process 7/1096 108/18670 0.4499 0.6163 0.418 ADIPOQ/PTK2B/PARM1/MAPK3/MAP3K4/RGN/PARP3 7 BP GO:0006284 base-excision repair 3/1096 42/18670 0.4511 0.6163 0.418 HUWE1/HMGA1/FAM168A 3 BP GO:0042149 cellular response to glucose starvation 3/1096 42/18670 0.4511 0.6163 0.418 XBP1/SIK1/HSPA5 3 BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 5/1096 75/18670 0.4518 0.6163 0.418 ITGAV/TAP1/TAPBP/NCF2/IKBKG 5 BP GO:0006695 cholesterol biosynthetic process 5/1096 75/18670 0.4518 0.6163 0.418 CYB5R3/ABCG1/LBR/PMVK/APOE 5 BP GO:0010921 regulation of phosphatase activity 11/1096 175/18670 0.4522 0.6163 0.418 MAGI2/TGFB2/PLEK/SMAD3/RGN/PTPRC/MGAT5/PPP1R2/NCKAP1L/PPP1R1A/RIMBP2 11 BP GO:0001660 fever generation 1/1096 10/18670 0.454 0.6163 0.418 IL1B 1 BP GO:0003211 cardiac ventricle formation 1/1096 10/18670 0.454 0.6163 0.418 SMARCD3 1 BP GO:0006228 UTP biosynthetic process 1/1096 10/18670 0.454 0.6163 0.418 NME3 1 BP GO:0006307 DNA dealkylation involved in DNA repair 1/1096 10/18670 0.454 0.6163 0.418 FTO 1 BP GO:0006547 histidine metabolic process 1/1096 10/18670 0.454 0.6163 0.418 HDC 1 BP GO:0007028 cytoplasm organization 1/1096 10/18670 0.454 0.6163 0.418 ZMIZ1 1 BP GO:0007440 foregut morphogenesis 1/1096 10/18670 0.454 0.6163 0.418 SMAD3 1 BP GO:0008343 adult feeding behavior 1/1096 10/18670 0.454 0.6163 0.418 USP46 1 BP GO:0009396 folic acid-containing compound biosynthetic process 1/1096 10/18670 0.454 0.6163 0.418 GCH1 1 BP GO:0010587 miRNA catabolic process 1/1096 10/18670 0.454 0.6163 0.418 SND1 1 BP GO:0010603 regulation of cytoplasmic mRNA processing body assembly 1/1096 10/18670 0.454 0.6163 0.418 CNOT1 1 BP GO:0010739 positive regulation of protein kinase A signaling 1/1096 10/18670 0.454 0.6163 0.418 ADIPOQ 1 BP GO:0010918 positive regulation of mitochondrial membrane potential 1/1096 10/18670 0.454 0.6163 0.418 BAD 1 BP GO:0010944 negative regulation of transcription by competitive promoter binding 1/1096 10/18670 0.454 0.6163 0.418 PHB 1 BP GO:0014049 positive regulation of glutamate secretion 1/1096 10/18670 0.454 0.6163 0.418 STXBP1 1 BP GO:0015801 aromatic amino acid transport 1/1096 10/18670 0.454 0.6163 0.418 SLC7A5 1 BP GO:0016559 peroxisome fission 1/1096 10/18670 0.454 0.6163 0.418 PEX19 1 BP GO:0018065 protein-cofactor linkage 1/1096 10/18670 0.454 0.6163 0.418 NNAT 1 BP GO:0021562 vestibulocochlear nerve development 1/1096 10/18670 0.454 0.6163 0.418 NRP2 1 BP GO:0021877 forebrain neuron fate commitment 1/1096 10/18670 0.454 0.6163 0.418 GATA2 1 BP GO:0032000 positive regulation of fatty acid beta-oxidation 1/1096 10/18670 0.454 0.6163 0.418 TWIST1 1 BP GO:0032025 response to cobalt ion 1/1096 10/18670 0.454 0.6163 0.418 BNIP3 1 BP GO:0032070 regulation of deoxyribonuclease activity 1/1096 10/18670 0.454 0.6163 0.418 GZMA 1 BP GO:0032308 positive regulation of prostaglandin secretion 1/1096 10/18670 0.454 0.6163 0.418 IL1B 1 BP GO:0032328 alanine transport 1/1096 10/18670 0.454 0.6163 0.418 SLC1A4 1 BP GO:0032353 negative regulation of hormone biosynthetic process 1/1096 10/18670 0.454 0.6163 0.418 NFKB1 1 BP GO:0032463 negative regulation of protein homooligomerization 1/1096 10/18670 0.454 0.6163 0.418 CRYAB 1 BP GO:0032926 negative regulation of activin receptor signaling pathway 1/1096 10/18670 0.454 0.6163 0.418 MAGI2 1 BP GO:0033131 regulation of glucokinase activity 1/1096 10/18670 0.454 0.6163 0.418 BAD 1 BP GO:0033210 leptin-mediated signaling pathway 1/1096 10/18670 0.454 0.6163 0.418 UGCG 1 BP GO:0033314 mitotic DNA replication checkpoint 1/1096 10/18670 0.454 0.6163 0.418 CDC6 1 BP GO:0033483 gas homeostasis 1/1096 10/18670 0.454 0.6163 0.418 HIF1A 1 BP GO:0033690 positive regulation of osteoblast proliferation 1/1096 10/18670 0.454 0.6163 0.418 ITGAV 1 BP GO:0034378 chylomicron assembly 1/1096 10/18670 0.454 0.6163 0.418 APOE 1 BP GO:0035247 peptidyl-arginine omega-N-methylation 1/1096 10/18670 0.454 0.6163 0.418 CARM1 1 BP GO:0035520 monoubiquitinated protein deubiquitination 1/1096 10/18670 0.454 0.6163 0.418 USP7 1 BP GO:0035871 protein K11-linked deubiquitination 1/1096 10/18670 0.454 0.6163 0.418 TNFAIP3 1 BP GO:0035999 tetrahydrofolate interconversion 1/1096 10/18670 0.454 0.6163 0.418 MTHFD2 1 BP GO:0039530 MDA-5 signaling pathway 1/1096 10/18670 0.454 0.6163 0.418 IRF7 1 BP GO:0042048 olfactory behavior 1/1096 10/18670 0.454 0.6163 0.418 WFS1 1 BP GO:0042989 sequestering of actin monomers 1/1096 10/18670 0.454 0.6163 0.418 GSN 1 BP GO:0043084 penile erection 1/1096 10/18670 0.454 0.6163 0.418 ADA 1 BP GO:0043653 mitochondrial fragmentation involved in apoptotic process 1/1096 10/18670 0.454 0.6163 0.418 BNIP3 1 BP GO:0044359 modulation of molecular function in other organism 1/1096 10/18670 0.454 0.6163 0.418 APCS 1 BP GO:0044539 long-chain fatty acid import 1/1096 10/18670 0.454 0.6163 0.418 SLC27A2 1 BP GO:0045348 positive regulation of MHC class II biosynthetic process 1/1096 10/18670 0.454 0.6163 0.418 XBP1 1 BP GO:0045625 regulation of T-helper 1 cell differentiation 1/1096 10/18670 0.454 0.6163 0.418 IL4R 1 BP GO:0045792 negative regulation of cell size 1/1096 10/18670 0.454 0.6163 0.418 CAV3 1 BP GO:0045945 positive regulation of transcription by RNA polymerase III 1/1096 10/18670 0.454 0.6163 0.418 AR 1 BP GO:0045988 negative regulation of striated muscle contraction 1/1096 10/18670 0.454 0.6163 0.418 BIN1 1 BP GO:0046710 GDP metabolic process 1/1096 10/18670 0.454 0.6163 0.418 GUK1 1 BP GO:0048149 behavioral response to ethanol 1/1096 10/18670 0.454 0.6163 0.418 USP46 1 BP GO:0048382 mesendoderm development 1/1096 10/18670 0.454 0.6163 0.418 BMPR1A 1 BP GO:0048755 branching morphogenesis of a nerve 1/1096 10/18670 0.454 0.6163 0.418 RERE 1 BP GO:0051901 positive regulation of mitochondrial depolarization 1/1096 10/18670 0.454 0.6163 0.418 MLLT11 1 BP GO:0051918 negative regulation of fibrinolysis 1/1096 10/18670 0.454 0.6163 0.418 SERPINE1 1 BP GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction 1/1096 10/18670 0.454 0.6163 0.418 APCS 1 BP GO:0052646 alditol phosphate metabolic process 1/1096 10/18670 0.454 0.6163 0.418 GK 1 BP GO:0060456 positive regulation of digestive system process 1/1096 10/18670 0.454 0.6163 0.418 AQP1 1 BP GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/1096 10/18670 0.454 0.6163 0.418 AR 1 BP GO:0061635 regulation of protein complex stability 1/1096 10/18670 0.454 0.6163 0.418 TAPBP 1 BP GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/1096 10/18670 0.454 0.6163 0.418 UBE2J1 1 BP GO:0071281 cellular response to iron ion 1/1096 10/18670 0.454 0.6163 0.418 CCNB1 1 BP GO:0071313 cellular response to caffeine 1/1096 10/18670 0.454 0.6163 0.418 CASQ2 1 BP GO:0071670 smooth muscle cell chemotaxis 1/1096 10/18670 0.454 0.6163 0.418 PARVA 1 BP GO:0072124 regulation of glomerular mesangial cell proliferation 1/1096 10/18670 0.454 0.6163 0.418 BMP4 1 BP GO:0072203 cell proliferation involved in metanephros development 1/1096 10/18670 0.454 0.6163 0.418 STAT1 1 BP GO:0072531 pyrimidine-containing compound transmembrane transport 1/1096 10/18670 0.454 0.6163 0.418 AQP9 1 BP GO:0072610 interleukin-12 secretion 1/1096 10/18670 0.454 0.6163 0.418 CCR7 1 BP GO:0090009 primitive streak formation 1/1096 10/18670 0.454 0.6163 0.418 ETS2 1 BP GO:0090205 positive regulation of cholesterol metabolic process 1/1096 10/18670 0.454 0.6163 0.418 ABCG1 1 BP GO:0090557 establishment of endothelial intestinal barrier 1/1096 10/18670 0.454 0.6163 0.418 ICAM1 1 BP GO:0097278 complement-dependent cytotoxicity 1/1096 10/18670 0.454 0.6163 0.418 RAB27A 1 BP GO:0098734 macromolecule depalmitoylation 1/1096 10/18670 0.454 0.6163 0.418 LYPLA1 1 BP GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/1096 10/18670 0.454 0.6163 0.418 MYD88 1 BP GO:1900426 positive regulation of defense response to bacterium 1/1096 10/18670 0.454 0.6163 0.418 UNC13B 1 BP GO:1901033 positive regulation of response to reactive oxygen species 1/1096 10/18670 0.454 0.6163 0.418 RGN 1 BP GO:1901526 positive regulation of mitophagy 1/1096 10/18670 0.454 0.6163 0.418 PINK1 1 BP GO:1902033 regulation of hematopoietic stem cell proliferation 1/1096 10/18670 0.454 0.6163 0.418 PIM1 1 BP GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/1096 10/18670 0.454 0.6163 0.418 PTPN2 1 BP GO:1902513 regulation of organelle transport along microtubule 1/1096 10/18670 0.454 0.6163 0.418 TRIM58 1 BP GO:1903332 regulation of protein folding 1/1096 10/18670 0.454 0.6163 0.418 HSPA5 1 BP GO:1903789 regulation of amino acid transmembrane transport 1/1096 10/18670 0.454 0.6163 0.418 RGS2 1 BP GO:1904338 regulation of dopaminergic neuron differentiation 1/1096 10/18670 0.454 0.6163 0.418 SFRP1 1 BP GO:1904526 regulation of microtubule binding 1/1096 10/18670 0.454 0.6163 0.418 MAPRE3 1 BP GO:1904684 negative regulation of metalloendopeptidase activity 1/1096 10/18670 0.454 0.6163 0.418 TIMP3 1 BP GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 1/1096 10/18670 0.454 0.6163 0.418 EEF2 1 BP GO:1990535 neuron projection maintenance 1/1096 10/18670 0.454 0.6163 0.418 INSR 1 BP GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/1096 10/18670 0.454 0.6163 0.418 ADAM19 1 BP GO:2000317 negative regulation of T-helper 17 type immune response 1/1096 10/18670 0.454 0.6163 0.418 IL27RA 1 BP GO:2000425 regulation of apoptotic cell clearance 1/1096 10/18670 0.454 0.6163 0.418 CCL2 1 BP GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/1096 10/18670 0.454 0.6163 0.418 PKIG 1 BP GO:2000628 regulation of miRNA metabolic process 1/1096 10/18670 0.454 0.6163 0.418 NFKB1 1 BP GO:2000644 regulation of receptor catabolic process 1/1096 10/18670 0.454 0.6163 0.418 APOE 1 BP GO:2001054 negative regulation of mesenchymal cell apoptotic process 1/1096 10/18670 0.454 0.6163 0.418 HIF1A 1 BP GO:2001225 regulation of chloride transport 1/1096 10/18670 0.454 0.6163 0.418 PTAFR 1 BP GO:0048839 inner ear development 12/1096 192/18670 0.4542 0.6164 0.4181 TGFB2/SIX1/GATA3/NTRK3/ZIC1/FZD2/FGFR1/GATA2/BMP4/CCNA2/ABR/PVALB 12 BP GO:0045833 negative regulation of lipid metabolic process 6/1096 92/18670 0.4562 0.6167 0.4183 IL1B/ADORA1/SIK1/NFKB1/APOC1/APOE 6 BP GO:0002230 positive regulation of defense response to virus by host 2/1096 26/18670 0.4563 0.6167 0.4183 AIM2/STAT1 2 BP GO:0006346 methylation-dependent chromatin silencing 2/1096 26/18670 0.4563 0.6167 0.4183 HDAC1/MBD2 2 BP GO:0010460 positive regulation of heart rate 2/1096 26/18670 0.4563 0.6167 0.4183 ADA/GCH1 2 BP GO:0032366 intracellular sterol transport 2/1096 26/18670 0.4563 0.6167 0.4183 NPC1/ABCG1 2 BP GO:0032367 intracellular cholesterol transport 2/1096 26/18670 0.4563 0.6167 0.4183 NPC1/ABCG1 2 BP GO:0032967 positive regulation of collagen biosynthetic process 2/1096 26/18670 0.4563 0.6167 0.4183 F2R/BMP4 2 BP GO:0042044 fluid transport 2/1096 26/18670 0.4563 0.6167 0.4183 AQP9/AQP1 2 BP GO:0051497 negative regulation of stress fiber assembly 2/1096 26/18670 0.4563 0.6167 0.4183 S1PR1/DLC1 2 BP GO:0051875 pigment granule localization 2/1096 26/18670 0.4563 0.6167 0.4183 RAB27A/DCTN2 2 BP GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/1096 26/18670 0.4563 0.6167 0.4183 PLN/CASQ2 2 BP GO:0060544 regulation of necroptotic process 2/1096 26/18670 0.4563 0.6167 0.4183 BIRC3/SLC25A4 2 BP GO:0060669 embryonic placenta morphogenesis 2/1096 26/18670 0.4563 0.6167 0.4183 SPINT2/ST14 2 BP GO:0060706 cell differentiation involved in embryonic placenta development 2/1096 26/18670 0.4563 0.6167 0.4183 SPINT2/ST14 2 BP GO:0072539 T-helper 17 cell differentiation 2/1096 26/18670 0.4563 0.6167 0.4183 BATF/NLRP3 2 BP GO:1903203 regulation of oxidative stress-induced neuron death 2/1096 26/18670 0.4563 0.6167 0.4183 HIF1A/PINK1 2 BP GO:1903959 regulation of anion transmembrane transport 2/1096 26/18670 0.4563 0.6167 0.4183 PTAFR/RGS2 2 BP GO:1904754 positive regulation of vascular associated smooth muscle cell migration 2/1096 26/18670 0.4563 0.6167 0.4183 PAK1/IGFBP5 2 BP GO:0010656 negative regulation of muscle cell apoptotic process 4/1096 59/18670 0.4586 0.6193 0.42 PTK2B/NUPR1/NOL3/HSPB6 4 BP GO:0010662 regulation of striated muscle cell apoptotic process 4/1096 59/18670 0.4586 0.6193 0.42 NUPR1/NOL3/HSPB6/BNIP3 4 BP GO:0032890 regulation of organic acid transport 4/1096 59/18670 0.4586 0.6193 0.42 STXBP1/IL1B/ADORA1/RGS2 4 BP GO:0045824 negative regulation of innate immune response 4/1096 59/18670 0.4586 0.6193 0.42 TNFAIP3/NMI/PTPN2/TYRO3 4 BP GO:0021761 limbic system development 7/1096 109/18670 0.4595 0.6202 0.4207 EZH1/SEMA3A/BTG2/FGFR1/ID4/HDAC1/NRP2 7 BP GO:0010948 negative regulation of cell cycle process 22/1096 361/18670 0.4596 0.6202 0.4207 PCGF2/ATRX/BTG2/CCND1/CNOT1/CDKN2C/NACC2/PTTG1/PLK2/BMP4/CDK4/CCNB1/EHMT2/CNOT4/CARM1/TFAP4/PLK1/CCL2/FHL1/RING1/ATF5/CDC6 22 BP GO:0009408 response to heat 11/1096 176/18670 0.4598 0.6204 0.4208 CRYAB/IGFBP7/DAXX/MAPK3/BAG1/HSPA5/CD14/PSIP1/CXCL10/CXCL12/NUP210 11 BP GO:0045333 cellular respiration 12/1096 193/18670 0.4614 0.6224 0.4221 MECP2/TRAP1/ALDH5A1/HIF1A/PINK1/CCNB1/COX6A2/NDUFB7/NDUFV1/BNIP3/UQCRC1/ETFB 12 BP GO:0018107 peptidyl-threonine phosphorylation 8/1096 126/18670 0.4621 0.6232 0.4227 CDK10/PRKCB/CDC42BPA/CHI3L1/CLK1/DYRK2/DDIT4/PLK1 8 BP GO:0001937 negative regulation of endothelial cell proliferation 5/1096 76/18670 0.4634 0.6243 0.4234 SULF1/STAT1/APOE/CCL2/FLT1 5 BP GO:0019674 NAD metabolic process 5/1096 76/18670 0.4634 0.6243 0.4234 NAMPT/PFKM/HK2/CD38/ALDOA 5 BP GO:0045454 cell redox homeostasis 5/1096 76/18670 0.4634 0.6243 0.4234 RAC2/GPX1/LPO/NCF2/PRDX2 5 BP GO:1902653 secondary alcohol biosynthetic process 5/1096 76/18670 0.4634 0.6243 0.4234 CYB5R3/ABCG1/LBR/PMVK/APOE 5 BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 23/1096 379/18670 0.4655 0.6268 0.4252 NOVA1/HTATSF1/KHDRBS3/CIRBP/SNRPA/FAM172A/NOL3/SRPK3/DDX39A/SAP18/POLR2E/JMJD6/PCBP2/SRSF8/PSIP1/PRPF8/CDC40/POLR2I/CASC3/SART1/SREK1/TFIP11/SNRPD2 23 BP GO:0000398 mRNA splicing, via spliceosome 23/1096 379/18670 0.4655 0.6268 0.4252 NOVA1/HTATSF1/KHDRBS3/CIRBP/SNRPA/FAM172A/NOL3/SRPK3/DDX39A/SAP18/POLR2E/JMJD6/PCBP2/SRSF8/PSIP1/PRPF8/CDC40/POLR2I/CASC3/SART1/SREK1/TFIP11/SNRPD2 23 BP GO:0010824 regulation of centrosome duplication 3/1096 43/18670 0.4666 0.6273 0.4255 PLK2/SPICE1/STIL 3 BP GO:0021795 cerebral cortex cell migration 3/1096 43/18670 0.4666 0.6273 0.4255 EGFR/SEMA3A/NRP2 3 BP GO:0032459 regulation of protein oligomerization 3/1096 43/18670 0.4666 0.6273 0.4255 CRYAB/AIM2/APOE 3 BP GO:0032924 activin receptor signaling pathway 3/1096 43/18670 0.4666 0.6273 0.4255 MAGI2/SMAD3/INHBB 3 BP GO:0034198 cellular response to amino acid starvation 3/1096 43/18670 0.4666 0.6273 0.4255 MAPK3/DAP/NPRL3 3 BP GO:0034383 low-density lipoprotein particle clearance 3/1096 43/18670 0.4666 0.6273 0.4255 ADIPOQ/NPC1/CSK 3 BP GO:0050850 positive regulation of calcium-mediated signaling 3/1096 43/18670 0.4666 0.6273 0.4255 P2RY6/ADA/CAMTA1 3 BP GO:0000045 autophagosome assembly 6/1096 93/18670 0.4667 0.6273 0.4255 PIP4K2B/NUPR1/GABARAPL1/PINK1/WDR45/NPRL3 6 BP GO:0051168 nuclear export 12/1096 194/18670 0.4686 0.6297 0.4271 EGR2/TCF7L2/IL1B/DDX39A/GAS6/SLBP/CDC40/PPM1A/CASC3/NXF1/NUP210/POLDIP3 12 BP GO:0033559 unsaturated fatty acid metabolic process 7/1096 110/18670 0.4691 0.6303 0.4275 LTC4S/PTGS1/HPGDS/IL1B/MAPK3/PTGDS/ALOX5 7 BP GO:0010659 cardiac muscle cell apoptotic process 4/1096 60/18670 0.4717 0.633 0.4293 NUPR1/NOL3/HSPB6/BNIP3 4 BP GO:0033013 tetrapyrrole metabolic process 4/1096 60/18670 0.4717 0.633 0.4293 BLVRA/NFE2L1/PPOX/UROD 4 BP GO:0033260 nuclear DNA replication 4/1096 60/18670 0.4717 0.633 0.4293 ATRX/FGFR1/SLBP/PRIM2 4 BP GO:0043966 histone H3 acetylation 4/1096 60/18670 0.4717 0.633 0.4293 KAT6B/GATA3/TADA3/JADE2 4 BP GO:0051306 mitotic sister chromatid separation 4/1096 60/18670 0.4717 0.633 0.4293 PTTG1/CCNB1/PLK1/CDC6 4 BP GO:2000779 regulation of double-strand break repair 5/1096 77/18670 0.4749 0.635 0.4307 ZNF365/TP53BP1/PARP3/TWIST1/TFIP11 5 BP GO:2001257 regulation of cation channel activity 11/1096 178/18670 0.4749 0.635 0.4307 P2RY6/ANK3/PTK2B/SHANK2/PLN/CASQ2/KCNAB1/PLCG2/CCR2/PINK1/CCL2 11 BP GO:0001964 startle response 2/1096 27/18670 0.4761 0.635 0.4307 MECP2/GLRB 2 BP GO:0007176 regulation of epidermal growth factor-activated receptor activity 2/1096 27/18670 0.4761 0.635 0.4307 TGFA/ADORA1 2 BP GO:0010714 positive regulation of collagen metabolic process 2/1096 27/18670 0.4761 0.635 0.4307 F2R/BMP4 2 BP GO:0035883 enteroendocrine cell differentiation 2/1096 27/18670 0.4761 0.635 0.4307 BMP4/BAD 2 BP GO:0036475 neuron death in response to oxidative stress 2/1096 27/18670 0.4761 0.635 0.4307 HIF1A/PINK1 2 BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2/1096 27/18670 0.4761 0.635 0.4307 BIRC3/IRF7 2 BP GO:0048143 astrocyte activation 2/1096 27/18670 0.4761 0.635 0.4307 EGFR/IL1B 2 BP GO:0051569 regulation of histone H3-K4 methylation 2/1096 27/18670 0.4761 0.635 0.4307 GATA3/AUTS2 2 BP GO:0051953 negative regulation of amine transport 2/1096 27/18670 0.4761 0.635 0.4307 ADORA1/RGS2 2 BP GO:0072378 blood coagulation, fibrin clot formation 2/1096 27/18670 0.4761 0.635 0.4307 TFPI/F8 2 BP GO:0080154 regulation of fertilization 2/1096 27/18670 0.4761 0.635 0.4307 PLCB1/STXBP1 2 BP GO:0098810 neurotransmitter reuptake 2/1096 27/18670 0.4761 0.635 0.4307 SLC29A1/SLC18A2 2 BP GO:1905563 negative regulation of vascular endothelial cell proliferation 2/1096 27/18670 0.4761 0.635 0.4307 CCL2/FLT1 2 BP GO:2000144 positive regulation of DNA-templated transcription, initiation 2/1096 27/18670 0.4761 0.635 0.4307 TWIST1/JUN 2 BP GO:0000726 non-recombinational repair 6/1096 94/18670 0.4771 0.635 0.4307 MDC1/TP53BP1/ERCC1/PARP3/KAT5/TFIP11 6 BP GO:0006906 vesicle fusion 6/1096 94/18670 0.4771 0.635 0.4307 CORO1A/STXBP1/STX11/TAP1/TBC1D4/TAPBP 6 BP GO:0042158 lipoprotein biosynthetic process 6/1096 94/18670 0.4771 0.635 0.4307 UGCG/GPAA1/PGAP2/APOE/WDR45/PPM1A 6 BP GO:0006406 mRNA export from nucleus 7/1096 111/18670 0.4787 0.635 0.4307 DDX39A/SLBP/CDC40/CASC3/NXF1/NUP210/POLDIP3 7 BP GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 7/1096 111/18670 0.4787 0.635 0.4307 DDX39A/SLBP/CDC40/CASC3/NXF1/NUP210/POLDIP3 7 BP GO:0006119 oxidative phosphorylation 9/1096 145/18670 0.4809 0.635 0.4307 MECP2/NUPR1/COX7A1/PINK1/CCNB1/COX6A2/NDUFB7/NDUFV1/UQCRC1 9 BP GO:0000375 RNA splicing, via transesterification reactions 23/1096 382/18670 0.481 0.635 0.4307 NOVA1/HTATSF1/KHDRBS3/CIRBP/SNRPA/FAM172A/NOL3/SRPK3/DDX39A/SAP18/POLR2E/JMJD6/PCBP2/SRSF8/PSIP1/PRPF8/CDC40/POLR2I/CASC3/SART1/SREK1/TFIP11/SNRPD2 23 BP GO:0010828 positive regulation of glucose transmembrane transport 3/1096 44/18670 0.4819 0.635 0.4307 ADIPOQ/ADIPOR2/INSR 3 BP GO:0014047 glutamate secretion 3/1096 44/18670 0.4819 0.635 0.4307 STXBP1/ADORA1/UNC13B 3 BP GO:0032965 regulation of collagen biosynthetic process 3/1096 44/18670 0.4819 0.635 0.4307 F2R/GOT1/BMP4 3 BP GO:0060999 positive regulation of dendritic spine development 3/1096 44/18670 0.4819 0.635 0.4307 SHANK2/DLG5/APOE 3 BP GO:0090382 phagosome maturation 3/1096 44/18670 0.4819 0.635 0.4307 CORO1A/UNC13B/ATP6V0D1 3 BP GO:1903214 regulation of protein targeting to mitochondrion 3/1096 44/18670 0.4819 0.635 0.4307 RAC2/HUWE1/PINK1 3 BP GO:0006879 cellular iron ion homeostasis 4/1096 61/18670 0.4847 0.635 0.4307 HIF1A/CP/TFRC/ATP6V0D1 4 BP GO:0042490 mechanoreceptor differentiation 4/1096 61/18670 0.4847 0.635 0.4307 NTRK3/FZD2/FGFR1/BMP4 4 BP GO:0031503 protein-containing complex localization 17/1096 281/18670 0.4849 0.635 0.4307 CLSTN1/KIF3B/DAG1/DDX39A/NACC2/DNM1/PURA/SLBP/HIP1/MAPK10/USP46/CDC40/CASC3/NXF1/NUP210/ICK/POLDIP3 17 BP GO:0000050 urea cycle 1/1096 11/18670 0.4861 0.635 0.4307 ASS1 1 BP GO:0000185 activation of MAPKKK activity 1/1096 11/18670 0.4861 0.635 0.4307 MAP4K1 1 BP GO:0001821 histamine secretion 1/1096 11/18670 0.4861 0.635 0.4307 ADA 1 BP GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure 1/1096 11/18670 0.4861 0.635 0.4307 MECP2 1 BP GO:0006048 UDP-N-acetylglucosamine biosynthetic process 1/1096 11/18670 0.4861 0.635 0.4307 GFPT1 1 BP GO:0006681 galactosylceramide metabolic process 1/1096 11/18670 0.4861 0.635 0.4307 ALDH5A1 1 BP GO:0009629 response to gravity 1/1096 11/18670 0.4861 0.635 0.4307 PTAFR 1 BP GO:0010269 response to selenium ion 1/1096 11/18670 0.4861 0.635 0.4307 GPX1 1 BP GO:0014820 tonic smooth muscle contraction 1/1096 11/18670 0.4861 0.635 0.4307 CD38 1 BP GO:0018095 protein polyglutamylation 1/1096 11/18670 0.4861 0.635 0.4307 TTLL1 1 BP GO:0031652 positive regulation of heat generation 1/1096 11/18670 0.4861 0.635 0.4307 IL1B 1 BP GO:0032060 bleb assembly 1/1096 11/18670 0.4861 0.635 0.4307 EMP2 1 BP GO:0032276 regulation of gonadotropin secretion 1/1096 11/18670 0.4861 0.635 0.4307 INHBB 1 BP GO:0032306 regulation of prostaglandin secretion 1/1096 11/18670 0.4861 0.635 0.4307 IL1B 1 BP GO:0032351 negative regulation of hormone metabolic process 1/1096 11/18670 0.4861 0.635 0.4307 NFKB1 1 BP GO:0032494 response to peptidoglycan 1/1096 11/18670 0.4861 0.635 0.4307 NLRP3 1 BP GO:0033235 positive regulation of protein sumoylation 1/1096 11/18670 0.4861 0.635 0.4307 HDAC4 1 BP GO:0033629 negative regulation of cell adhesion mediated by integrin 1/1096 11/18670 0.4861 0.635 0.4307 SERPINE1 1 BP GO:0033860 regulation of NAD(P)H oxidase activity 1/1096 11/18670 0.4861 0.635 0.4307 AGTR1 1 BP GO:0034379 very-low-density lipoprotein particle assembly 1/1096 11/18670 0.4861 0.635 0.4307 APOC1 1 BP GO:0034776 response to histamine 1/1096 11/18670 0.4861 0.635 0.4307 GABRB1 1 BP GO:0035246 peptidyl-arginine N-methylation 1/1096 11/18670 0.4861 0.635 0.4307 CARM1 1 BP GO:0035404 histone-serine phosphorylation 1/1096 11/18670 0.4861 0.635 0.4307 CCNB1 1 BP GO:0035542 regulation of SNARE complex assembly 1/1096 11/18670 0.4861 0.635 0.4307 STXBP1 1 BP GO:0040015 negative regulation of multicellular organism growth 1/1096 11/18670 0.4861 0.635 0.4307 LGMN 1 BP GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/1096 11/18670 0.4861 0.635 0.4307 HIF1A 1 BP GO:0045176 apical protein localization 1/1096 11/18670 0.4861 0.635 0.4307 DLG5 1 BP GO:0045217 cell-cell junction maintenance 1/1096 11/18670 0.4861 0.635 0.4307 F2R 1 BP GO:0045919 positive regulation of cytolysis 1/1096 11/18670 0.4861 0.635 0.4307 LBP 1 BP GO:0046051 UTP metabolic process 1/1096 11/18670 0.4861 0.635 0.4307 NME3 1 BP GO:0046185 aldehyde catabolic process 1/1096 11/18670 0.4861 0.635 0.4307 ALDH3B1 1 BP GO:0046950 cellular ketone body metabolic process 1/1096 11/18670 0.4861 0.635 0.4307 OXCT1 1 BP GO:0048096 chromatin-mediated maintenance of transcription 1/1096 11/18670 0.4861 0.635 0.4307 ZMIZ1 1 BP GO:0048548 regulation of pinocytosis 1/1096 11/18670 0.4861 0.635 0.4307 AXL 1 BP GO:0048680 positive regulation of axon regeneration 1/1096 11/18670 0.4861 0.635 0.4307 NTRK3 1 BP GO:0048742 regulation of skeletal muscle fiber development 1/1096 11/18670 0.4861 0.635 0.4307 HDAC4 1 BP GO:0051974 negative regulation of telomerase activity 1/1096 11/18670 0.4861 0.635 0.4307 PARP3 1 BP GO:0055091 phospholipid homeostasis 1/1096 11/18670 0.4861 0.635 0.4307 ABCG1 1 BP GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/1096 11/18670 0.4861 0.635 0.4307 CASQ2 1 BP GO:0060736 prostate gland growth 1/1096 11/18670 0.4861 0.635 0.4307 AR 1 BP GO:0060767 epithelial cell proliferation involved in prostate gland development 1/1096 11/18670 0.4861 0.635 0.4307 AR 1 BP GO:0060856 establishment of blood-brain barrier 1/1096 11/18670 0.4861 0.635 0.4307 MXRA8 1 BP GO:0060947 cardiac vascular smooth muscle cell differentiation 1/1096 11/18670 0.4861 0.635 0.4307 VEGFA 1 BP GO:0061085 regulation of histone H3-K27 methylation 1/1096 11/18670 0.4861 0.635 0.4307 GATA3 1 BP GO:0070104 negative regulation of interleukin-6-mediated signaling pathway 1/1096 11/18670 0.4861 0.635 0.4307 PTPN2 1 BP GO:0070189 kynurenine metabolic process 1/1096 11/18670 0.4861 0.635 0.4307 GOT2 1 BP GO:0070213 protein auto-ADP-ribosylation 1/1096 11/18670 0.4861 0.635 0.4307 PARP3 1 BP GO:0070269 pyroptosis 1/1096 11/18670 0.4861 0.635 0.4307 AIM2 1 BP GO:0070278 extracellular matrix constituent secretion 1/1096 11/18670 0.4861 0.635 0.4307 TNFRSF1B 1 BP GO:0070673 response to interleukin-18 1/1096 11/18670 0.4861 0.635 0.4307 ALOX5 1 BP GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/1096 11/18670 0.4861 0.635 0.4307 EFNA5 1 BP GO:0072110 glomerular mesangial cell proliferation 1/1096 11/18670 0.4861 0.635 0.4307 BMP4 1 BP GO:0072321 chaperone-mediated protein transport 1/1096 11/18670 0.4861 0.635 0.4307 PEX19 1 BP GO:0072537 fibroblast activation 1/1096 11/18670 0.4861 0.635 0.4307 IL17RA 1 BP GO:0072711 cellular response to hydroxyurea 1/1096 11/18670 0.4861 0.635 0.4307 ATRX 1 BP GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 1/1096 11/18670 0.4861 0.635 0.4307 PLN 1 BP GO:0090042 tubulin deacetylation 1/1096 11/18670 0.4861 0.635 0.4307 TADA3 1 BP GO:0090084 negative regulation of inclusion body assembly 1/1096 11/18670 0.4861 0.635 0.4307 SACS 1 BP GO:0090193 positive regulation of glomerulus development 1/1096 11/18670 0.4861 0.635 0.4307 ADIPOQ 1 BP GO:0098883 synapse pruning 1/1096 11/18670 0.4861 0.635 0.4307 CX3CR1 1 BP GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 1/1096 11/18670 0.4861 0.635 0.4307 USP46 1 BP GO:0099151 regulation of postsynaptic density assembly 1/1096 11/18670 0.4861 0.635 0.4307 NTRK3 1 BP GO:1901077 regulation of relaxation of muscle 1/1096 11/18670 0.4861 0.635 0.4307 PLN 1 BP GO:1901201 regulation of extracellular matrix assembly 1/1096 11/18670 0.4861 0.635 0.4307 SMAD3 1 BP GO:1901569 fatty acid derivative catabolic process 1/1096 11/18670 0.4861 0.635 0.4307 OXCT1 1 BP GO:1902093 positive regulation of flagellated sperm motility 1/1096 11/18670 0.4861 0.635 0.4307 CCR6 1 BP GO:1902805 positive regulation of synaptic vesicle transport 1/1096 11/18670 0.4861 0.635 0.4307 UNC13B 1 BP GO:1903011 negative regulation of bone development 1/1096 11/18670 0.4861 0.635 0.4307 RGN 1 BP GO:1903299 regulation of hexokinase activity 1/1096 11/18670 0.4861 0.635 0.4307 BAD 1 BP GO:1903441 protein localization to ciliary membrane 1/1096 11/18670 0.4861 0.635 0.4307 RAB29 1 BP GO:1903977 positive regulation of glial cell migration 1/1096 11/18670 0.4861 0.635 0.4307 CCR2 1 BP GO:1903980 positive regulation of microglial cell activation 1/1096 11/18670 0.4861 0.635 0.4307 CTSC 1 BP GO:1904396 regulation of neuromuscular junction development 1/1096 11/18670 0.4861 0.635 0.4307 SIX1 1 BP GO:1904468 negative regulation of tumor necrosis factor secretion 1/1096 11/18670 0.4861 0.635 0.4307 IL27RA 1 BP GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/1096 11/18670 0.4861 0.635 0.4307 CXCL12 1 BP GO:1905214 regulation of RNA binding 1/1096 11/18670 0.4861 0.635 0.4307 CARM1 1 BP GO:1905245 regulation of aspartic-type peptidase activity 1/1096 11/18670 0.4861 0.635 0.4307 BIN1 1 BP GO:1905383 protein localization to presynapse 1/1096 11/18670 0.4861 0.635 0.4307 HSPB1 1 BP GO:1905941 positive regulation of gonad development 1/1096 11/18670 0.4861 0.635 0.4307 SEMA3A 1 BP GO:2000318 positive regulation of T-helper 17 type immune response 1/1096 11/18670 0.4861 0.635 0.4307 NLRP3 1 BP GO:2000615 regulation of histone H3-K9 acetylation 1/1096 11/18670 0.4861 0.635 0.4307 GATA3 1 BP GO:2000767 positive regulation of cytoplasmic translation 1/1096 11/18670 0.4861 0.635 0.4307 EEF2 1 BP GO:2000786 positive regulation of autophagosome assembly 1/1096 11/18670 0.4861 0.635 0.4307 PIP4K2B 1 BP GO:0000271 polysaccharide biosynthetic process 5/1096 78/18670 0.4863 0.6352 0.4308 PPP1R3C/ENPP1/NFKB1/INSR/DYRK2 5 BP GO:0045069 regulation of viral genome replication 6/1096 95/18670 0.4874 0.6362 0.4315 CCL5/SLPI/CXCL8/PLSCR1/ISG20/VAPA 6 BP GO:0050810 regulation of steroid biosynthetic process 6/1096 95/18670 0.4874 0.6362 0.4315 IL1B/IGFBP7/NFKB1/ABCG1/PMVK/APOE 6 BP GO:0097711 ciliary basal body-plasma membrane docking 6/1096 95/18670 0.4874 0.6362 0.4315 DCTN3/AKAP9/B9D1/CETN2/DCTN2/PLK1 6 BP GO:0000041 transition metal ion transport 7/1096 112/18670 0.4882 0.6369 0.432 ARHGAP1/SLC39A8/CP/SLC39A14/SLC39A7/TFRC/ATP6V0D1 7 BP GO:0017158 regulation of calcium ion-dependent exocytosis 7/1096 112/18670 0.4882 0.6369 0.432 STXBP1/PRKCB/SYT17/UNC13B/RIMS3/PFN2/ADCY1 7 BP GO:2001020 regulation of response to DNA damage stimulus 13/1096 214/18670 0.4904 0.6396 0.4338 EGFR/ZNF365/TP53BP1/CD44/NACC2/ERCC1/PARP3/CXCL12/TWIST1/FAM168A/CUL4A/TFIP11/PTTG1IP 13 BP GO:0006760 folic acid-containing compound metabolic process 2/1096 28/18670 0.4954 0.644 0.4368 GCH1/MTHFD2 2 BP GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 2/1096 28/18670 0.4954 0.644 0.4368 F2R/GAP43 2 BP GO:0010894 negative regulation of steroid biosynthetic process 2/1096 28/18670 0.4954 0.644 0.4368 NFKB1/APOE 2 BP GO:0033137 negative regulation of peptidyl-serine phosphorylation 2/1096 28/18670 0.4954 0.644 0.4368 INPP5F/DDIT4 2 BP GO:0034377 plasma lipoprotein particle assembly 2/1096 28/18670 0.4954 0.644 0.4368 APOC1/APOE 2 BP GO:0042730 fibrinolysis 2/1096 28/18670 0.4954 0.644 0.4368 PLAUR/SERPINE1 2 BP GO:0045686 negative regulation of glial cell differentiation 2/1096 28/18670 0.4954 0.644 0.4368 NTRK3/ID4 2 BP GO:0050686 negative regulation of mRNA processing 2/1096 28/18670 0.4954 0.644 0.4368 SAP18/SUPT5H 2 BP GO:0051984 positive regulation of chromosome segregation 2/1096 28/18670 0.4954 0.644 0.4368 CCNB1/CDC6 2 BP GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/1096 28/18670 0.4954 0.644 0.4368 THRA/CTNNBIP1 2 BP GO:0070861 regulation of protein exit from endoplasmic reticulum 2/1096 28/18670 0.4954 0.644 0.4368 TM9SF4/UBE2J1 2 BP GO:0071168 protein localization to chromatin 2/1096 28/18670 0.4954 0.644 0.4368 CARM1/PLK1 2 BP GO:2000108 positive regulation of leukocyte apoptotic process 2/1096 28/18670 0.4954 0.644 0.4368 CCL5/ADAM8 2 BP GO:2000463 positive regulation of excitatory postsynaptic potential 2/1096 28/18670 0.4954 0.644 0.4368 PTK2B/SHANK2 2 BP GO:2001025 positive regulation of response to drug 2/1096 28/18670 0.4954 0.644 0.4368 PINK1/CXCL12 2 BP GO:0031018 endocrine pancreas development 3/1096 45/18670 0.497 0.6446 0.4372 FOXO1/BMP4/BAD 3 BP GO:0032456 endocytic recycling 3/1096 45/18670 0.497 0.6446 0.4372 ARL4C/ARHGAP1/INPP5F 3 BP GO:0051932 synaptic transmission, GABAergic 3/1096 45/18670 0.497 0.6446 0.4372 STXBP1/ADORA1/USP46 3 BP GO:0070316 regulation of G0 to G1 transition 3/1096 45/18670 0.497 0.6446 0.4372 PCGF2/EHMT2/RING1 3 BP GO:0090278 negative regulation of peptide hormone secretion 3/1096 45/18670 0.497 0.6446 0.4372 HADH/SFRP1/INHBB 3 BP GO:0003407 neural retina development 4/1096 62/18670 0.4975 0.6446 0.4372 TGFB2/SMARCD3/THY1/DIO3 4 BP GO:0010658 striated muscle cell apoptotic process 4/1096 62/18670 0.4975 0.6446 0.4372 NUPR1/NOL3/HSPB6/BNIP3 4 BP GO:0050433 regulation of catecholamine secretion 4/1096 62/18670 0.4975 0.6446 0.4372 SYT17/PINK1/SNCG/CXCL12 4 BP GO:0051898 negative regulation of protein kinase B signaling 4/1096 62/18670 0.4975 0.6446 0.4372 MAGI2/PHLPP1/DAG1/RAPGEF1 4 BP GO:1905818 regulation of chromosome separation 4/1096 62/18670 0.4975 0.6446 0.4372 PTTG1/CCNB1/PLK1/CDC6 4 BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 5/1096 79/18670 0.4976 0.6446 0.4372 ITGAV/TAP1/TAPBP/NCF2/IKBKG 5 BP GO:0045652 regulation of megakaryocyte differentiation 5/1096 79/18670 0.4976 0.6446 0.4372 MYL9/GATA2/HDAC1/PF4/CNOT4 5 BP GO:0055072 iron ion homeostasis 5/1096 79/18670 0.4976 0.6446 0.4372 STEAP1/HIF1A/CP/TFRC/ATP6V0D1 5 BP GO:0010660 regulation of muscle cell apoptotic process 6/1096 96/18670 0.4977 0.6446 0.4372 PDE1A/PTK2B/NUPR1/NOL3/HSPB6/BNIP3 6 BP GO:0030219 megakaryocyte differentiation 6/1096 96/18670 0.4977 0.6446 0.4372 PTPN6/MYL9/GATA2/HDAC1/PF4/CNOT4 6 BP GO:1905037 autophagosome organization 6/1096 96/18670 0.4977 0.6446 0.4372 PIP4K2B/NUPR1/GABARAPL1/PINK1/WDR45/NPRL3 6 BP GO:0007093 mitotic cell cycle checkpoint 10/1096 165/18670 0.5053 0.6506 0.4413 MDC1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1/CDC6 10 BP GO:0010633 negative regulation of epithelial cell migration 7/1096 114/18670 0.5071 0.6506 0.4413 CXCL13/MECP2/SEMA3A/STC1/APOE/ANGPT2/PFN2 7 BP GO:0034968 histone lysine methylation 7/1096 114/18670 0.5071 0.6506 0.4413 EZH1/MECP2/GATA3/ATRX/AUTS2/EHMT2/JARID2 7 BP GO:0015908 fatty acid transport 6/1096 97/18670 0.5079 0.6506 0.4413 FABP4/IL1B/GOT2/NMB/SLC27A2/APOE 6 BP GO:0033045 regulation of sister chromatid segregation 5/1096 80/18670 0.5089 0.6506 0.4413 ATRX/PTTG1/CCNB1/PLK1/CDC6 5 BP GO:0048194 Golgi vesicle budding 5/1096 80/18670 0.5089 0.6506 0.4413 TGFA/SERPINA1/CTSC/F8/VAPA 5 BP GO:0140029 exocytic process 5/1096 80/18670 0.5089 0.6506 0.4413 STXBP1/STX11/PLEK/STXBP2/UNC13B 5 BP GO:0035418 protein localization to synapse 4/1096 63/18670 0.5101 0.6506 0.4413 CLSTN1/DAG1/HSPB1/MAPK10 4 BP GO:0042982 amyloid precursor protein metabolic process 4/1096 63/18670 0.5101 0.6506 0.4413 BIN1/ABCG1/PIN1/APOE 4 BP GO:0045815 positive regulation of gene expression, epigenetic 4/1096 63/18670 0.5101 0.6506 0.4413 HMGA1/POLR2E/ZMIZ1/POLR1C 4 BP GO:0046530 photoreceptor cell differentiation 4/1096 63/18670 0.5101 0.6506 0.4413 VEGFA/CRX/THY1/DIO3 4 BP GO:0071804 cellular potassium ion transport 13/1096 217/18670 0.5109 0.6506 0.4413 ANK3/BIN1/NEDD4L/KCNJ8/CASQ2/KCNAB1/ATP4B/CAV3/AKAP9/AQP1/KCNB2/KCNN3/FHL1 13 BP GO:0071805 potassium ion transmembrane transport 13/1096 217/18670 0.5109 0.6506 0.4413 ANK3/BIN1/NEDD4L/KCNJ8/CASQ2/KCNAB1/ATP4B/CAV3/AKAP9/AQP1/KCNB2/KCNN3/FHL1 13 BP GO:0001504 neurotransmitter uptake 3/1096 46/18670 0.5119 0.6506 0.4413 RGS2/SLC29A1/SLC18A2 3 BP GO:0001754 eye photoreceptor cell differentiation 3/1096 46/18670 0.5119 0.6506 0.4413 VEGFA/THY1/DIO3 3 BP GO:0032369 negative regulation of lipid transport 3/1096 46/18670 0.5119 0.6506 0.4413 ITGAV/NFKB1/APOC1 3 BP GO:0032527 protein exit from endoplasmic reticulum 3/1096 46/18670 0.5119 0.6506 0.4413 TM9SF4/UBE2J1/HERPUD1 3 BP GO:0043330 response to exogenous dsRNA 3/1096 46/18670 0.5119 0.6506 0.4413 RFTN1/MAPK3/NFKBIA 3 BP GO:0051339 regulation of lyase activity 3/1096 46/18670 0.5119 0.6506 0.4413 TIMP2/CCR2/AKAP9 3 BP GO:0051646 mitochondrion localization 3/1096 46/18670 0.5119 0.6506 0.4413 HIF1A/UCHL1/ATP2A1 3 BP GO:1900015 regulation of cytokine production involved in inflammatory response 3/1096 46/18670 0.5119 0.6506 0.4413 GPSM3/MYD88/IL17RA 3 BP GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 3/1096 46/18670 0.5119 0.6506 0.4413 VEGFA/GATA2/AGTR1 3 BP GO:1990928 response to amino acid starvation 3/1096 46/18670 0.5119 0.6506 0.4413 MAPK3/DAP/NPRL3 3 BP GO:0010644 cell communication by electrical coupling 2/1096 29/18670 0.5143 0.6506 0.4413 ANK3/CASQ2 2 BP GO:0010800 positive regulation of peptidyl-threonine phosphorylation 2/1096 29/18670 0.5143 0.6506 0.4413 CHI3L1/PLK1 2 BP GO:0016577 histone demethylation 2/1096 29/18670 0.5143 0.6506 0.4413 JMJD6/JARID2 2 BP GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 2/1096 29/18670 0.5143 0.6506 0.4413 TGFBR3/GOT1 2 BP GO:0030970 retrograde protein transport, ER to cytosol 2/1096 29/18670 0.5143 0.6506 0.4413 UBE2J1/HERPUD1 2 BP GO:0031114 regulation of microtubule depolymerization 2/1096 29/18670 0.5143 0.6506 0.4413 CAMSAP2/STMN2 2 BP GO:0032232 negative regulation of actin filament bundle assembly 2/1096 29/18670 0.5143 0.6506 0.4413 S1PR1/DLC1 2 BP GO:0032372 negative regulation of sterol transport 2/1096 29/18670 0.5143 0.6506 0.4413 NFKB1/APOC1 2 BP GO:0032375 negative regulation of cholesterol transport 2/1096 29/18670 0.5143 0.6506 0.4413 NFKB1/APOC1 2 BP GO:0035025 positive regulation of Rho protein signal transduction 2/1096 29/18670 0.5143 0.6506 0.4413 F2R/COL3A1 2 BP GO:0044030 regulation of DNA methylation 2/1096 29/18670 0.5143 0.6506 0.4413 MECP2/MBD2 2 BP GO:0048730 epidermis morphogenesis 2/1096 29/18670 0.5143 0.6506 0.4413 TGFB2/IGFBP5 2 BP GO:0060536 cartilage morphogenesis 2/1096 29/18670 0.5143 0.6506 0.4413 STC1/HOXA5 2 BP GO:0070102 interleukin-6-mediated signaling pathway 2/1096 29/18670 0.5143 0.6506 0.4413 STAT1/PTPN2 2 BP GO:1903513 endoplasmic reticulum to cytosol transport 2/1096 29/18670 0.5143 0.6506 0.4413 UBE2J1/HERPUD1 2 BP GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 2/1096 29/18670 0.5143 0.6506 0.4413 TGFBR3/GOT1 2 BP GO:2000036 regulation of stem cell population maintenance 2/1096 29/18670 0.5143 0.6506 0.4413 LOXL2/CNOT1 2 BP GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 2/1096 29/18670 0.5143 0.6506 0.4413 RUNX3/IL4R 2 BP GO:2000727 positive regulation of cardiac muscle cell differentiation 2/1096 29/18670 0.5143 0.6506 0.4413 PIN1/BMP4 2 BP GO:0001682 tRNA 5'-leader removal 1/1096 12/18670 0.5163 0.6506 0.4413 RPP40 1 BP GO:0002002 regulation of angiotensin levels in blood 1/1096 12/18670 0.5163 0.6506 0.4413 CPA3 1 BP GO:0002003 angiotensin maturation 1/1096 12/18670 0.5163 0.6506 0.4413 CPA3 1 BP GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/1096 12/18670 0.5163 0.6506 0.4413 CCR7 1 BP GO:0002903 negative regulation of B cell apoptotic process 1/1096 12/18670 0.5163 0.6506 0.4413 ADA 1 BP GO:0003161 cardiac conduction system development 1/1096 12/18670 0.5163 0.6506 0.4413 BMPR1A 1 BP GO:0003207 cardiac chamber formation 1/1096 12/18670 0.5163 0.6506 0.4413 SMARCD3 1 BP GO:0006068 ethanol catabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 ALDH3B1 1 BP GO:0006527 arginine catabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 FAH 1 BP GO:0006554 lysine catabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 CRYM 1 BP GO:0006563 L-serine metabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 SDS 1 BP GO:0007288 sperm axoneme assembly 1/1096 12/18670 0.5163 0.6506 0.4413 TTLL1 1 BP GO:0007320 insemination 1/1096 12/18670 0.5163 0.6506 0.4413 SERPINE2 1 BP GO:0008228 opsonization 1/1096 12/18670 0.5163 0.6506 0.4413 LBP 1 BP GO:0009265 2'-deoxyribonucleotide biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 GUK1 1 BP GO:0010889 regulation of sequestering of triglyceride 1/1096 12/18670 0.5163 0.6506 0.4413 LPL 1 BP GO:0014029 neural crest formation 1/1096 12/18670 0.5163 0.6506 0.4413 SFRP1 1 BP GO:0015816 glycine transport 1/1096 12/18670 0.5163 0.6506 0.4413 RGS2 1 BP GO:0015867 ATP transport 1/1096 12/18670 0.5163 0.6506 0.4413 SLC25A4 1 BP GO:0016045 detection of bacterium 1/1096 12/18670 0.5163 0.6506 0.4413 TLR2 1 BP GO:0016081 synaptic vesicle docking 1/1096 12/18670 0.5163 0.6506 0.4413 UNC13B 1 BP GO:0019374 galactolipid metabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 ALDH5A1 1 BP GO:0021559 trigeminal nerve development 1/1096 12/18670 0.5163 0.6506 0.4413 SEMA3A 1 BP GO:0021889 olfactory bulb interneuron differentiation 1/1096 12/18670 0.5163 0.6506 0.4413 ATF5 1 BP GO:0030002 cellular anion homeostasis 1/1096 12/18670 0.5163 0.6506 0.4413 ENPP1 1 BP GO:0030157 pancreatic juice secretion 1/1096 12/18670 0.5163 0.6506 0.4413 AQP1 1 BP GO:0030208 dermatan sulfate biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 UST 1 BP GO:0030320 cellular monovalent inorganic anion homeostasis 1/1096 12/18670 0.5163 0.6506 0.4413 ENPP1 1 BP GO:0030950 establishment or maintenance of actin cytoskeleton polarity 1/1096 12/18670 0.5163 0.6506 0.4413 AQP1 1 BP GO:0031126 snoRNA 3'-end processing 1/1096 12/18670 0.5163 0.6506 0.4413 FBL 1 BP GO:0031392 regulation of prostaglandin biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 IL1B 1 BP GO:0031507 heterochromatin assembly 1/1096 12/18670 0.5163 0.6506 0.4413 HMGA1 1 BP GO:0031581 hemidesmosome assembly 1/1096 12/18670 0.5163 0.6506 0.4413 DST 1 BP GO:0032252 secretory granule localization 1/1096 12/18670 0.5163 0.6506 0.4413 RASGRP1 1 BP GO:0033523 histone H2B ubiquitination 1/1096 12/18670 0.5163 0.6506 0.4413 PAF1 1 BP GO:0034086 maintenance of sister chromatid cohesion 1/1096 12/18670 0.5163 0.6506 0.4413 ATRX 1 BP GO:0034088 maintenance of mitotic sister chromatid cohesion 1/1096 12/18670 0.5163 0.6506 0.4413 ATRX 1 BP GO:0034497 protein localization to phagophore assembly site 1/1096 12/18670 0.5163 0.6506 0.4413 WDR45 1 BP GO:0035092 sperm chromatin condensation 1/1096 12/18670 0.5163 0.6506 0.4413 TNP2 1 BP GO:0035330 regulation of hippo signaling 1/1096 12/18670 0.5163 0.6506 0.4413 DLG5 1 BP GO:0035721 intraciliary retrograde transport 1/1096 12/18670 0.5163 0.6506 0.4413 ICK 1 BP GO:0042118 endothelial cell activation 1/1096 12/18670 0.5163 0.6506 0.4413 CXCL10 1 BP GO:0042340 keratan sulfate catabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 HEXA 1 BP GO:0045080 positive regulation of chemokine biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 IL1B 1 BP GO:0045416 positive regulation of interleukin-8 biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 ELANE 1 BP GO:0045472 response to ether 1/1096 12/18670 0.5163 0.6506 0.4413 CDK4 1 BP GO:0045760 positive regulation of action potential 1/1096 12/18670 0.5163 0.6506 0.4413 ANK3 1 BP GO:0046385 deoxyribose phosphate biosynthetic process 1/1096 12/18670 0.5163 0.6506 0.4413 GUK1 1 BP GO:0048642 negative regulation of skeletal muscle tissue development 1/1096 12/18670 0.5163 0.6506 0.4413 TWIST1 1 BP GO:0048934 peripheral nervous system neuron differentiation 1/1096 12/18670 0.5163 0.6506 0.4413 RUNX3 1 BP GO:0048935 peripheral nervous system neuron development 1/1096 12/18670 0.5163 0.6506 0.4413 RUNX3 1 BP GO:0051608 histamine transport 1/1096 12/18670 0.5163 0.6506 0.4413 ADA 1 BP GO:0051798 positive regulation of hair follicle development 1/1096 12/18670 0.5163 0.6506 0.4413 TGFB2 1 BP GO:0052803 imidazole-containing compound metabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 HDC 1 BP GO:0060019 radial glial cell differentiation 1/1096 12/18670 0.5163 0.6506 0.4413 CDH2 1 BP GO:0060900 embryonic camera-type eye formation 1/1096 12/18670 0.5163 0.6506 0.4413 TWIST1 1 BP GO:0061450 trophoblast cell migration 1/1096 12/18670 0.5163 0.6506 0.4413 ARHGDIB 1 BP GO:0070572 positive regulation of neuron projection regeneration 1/1096 12/18670 0.5163 0.6506 0.4413 NTRK3 1 BP GO:0071107 response to parathyroid hormone 1/1096 12/18670 0.5163 0.6506 0.4413 HDAC4 1 BP GO:0071468 cellular response to acidic pH 1/1096 12/18670 0.5163 0.6506 0.4413 PCK1 1 BP GO:0072540 T-helper 17 cell lineage commitment 1/1096 12/18670 0.5163 0.6506 0.4413 BATF 1 BP GO:0072710 response to hydroxyurea 1/1096 12/18670 0.5163 0.6506 0.4413 ATRX 1 BP GO:0090148 membrane fission 1/1096 12/18670 0.5163 0.6506 0.4413 MX2 1 BP GO:0097090 presynaptic membrane organization 1/1096 12/18670 0.5163 0.6506 0.4413 APOE 1 BP GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/1096 12/18670 0.5163 0.6506 0.4413 JUN 1 BP GO:0097284 hepatocyte apoptotic process 1/1096 12/18670 0.5163 0.6506 0.4413 GSN 1 BP GO:0098974 postsynaptic actin cytoskeleton organization 1/1096 12/18670 0.5163 0.6506 0.4413 MYH10 1 BP GO:0099550 trans-synaptic signaling, modulating synaptic transmission 1/1096 12/18670 0.5163 0.6506 0.4413 F2R 1 BP GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter 1/1096 12/18670 0.5163 0.6506 0.4413 FOXO1 1 BP GO:1901163 regulation of trophoblast cell migration 1/1096 12/18670 0.5163 0.6506 0.4413 ARHGDIB 1 BP GO:1902224 ketone body metabolic process 1/1096 12/18670 0.5163 0.6506 0.4413 OXCT1 1 BP GO:1902414 protein localization to cell junction 1/1096 12/18670 0.5163 0.6506 0.4413 DLG5 1 BP GO:1903894 regulation of IRE1-mediated unfolded protein response 1/1096 12/18670 0.5163 0.6506 0.4413 HSPA5 1 BP GO:1903909 regulation of receptor clustering 1/1096 12/18670 0.5163 0.6506 0.4413 GSN 1 BP GO:1904668 positive regulation of ubiquitin protein ligase activity 1/1096 12/18670 0.5163 0.6506 0.4413 PLK1 1 BP GO:1905522 negative regulation of macrophage migration 1/1096 12/18670 0.5163 0.6506 0.4413 CD200 1 BP GO:2000344 positive regulation of acrosome reaction 1/1096 12/18670 0.5163 0.6506 0.4413 PLCB1 1 BP GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1/1096 12/18670 0.5163 0.6506 0.4413 NEDD4L 1 BP GO:2001053 regulation of mesenchymal cell apoptotic process 1/1096 12/18670 0.5163 0.6506 0.4413 HIF1A 1 BP GO:2001223 negative regulation of neuron migration 1/1096 12/18670 0.5163 0.6506 0.4413 COL3A1 1 BP GO:0006814 sodium ion transport 13/1096 218/18670 0.5177 0.6522 0.4424 SERPINE2/ANK3/MAGED2/FXYD1/SLC5A3/NEDD4L/SIK1/SLC23A2/SLC20A1/ATP4B/SLC20A2/CAV3/SNTA1 13 BP GO:0007031 peroxisome organization 5/1096 81/18670 0.52 0.6549 0.4442 ECH1/CRAT/PEX19/SLC27A2/ACOX2 5 BP GO:0032204 regulation of telomere maintenance 5/1096 81/18670 0.52 0.6549 0.4442 ATRX/MAPK3/MAP3K4/ERCC1/USP7 5 BP GO:0007338 single fertilization 9/1096 150/18670 0.5222 0.6574 0.4459 PLCB1/HOXA10/STXBP1/AR/UNC13B/GLRB/HOXA11/ALDOA/TNP2 9 BP GO:0043297 apical junction assembly 4/1096 64/18670 0.5227 0.6579 0.4463 ARL2/DLG5/PECAM1/PRKCH 4 BP GO:0006612 protein targeting to membrane 12/1096 202/18670 0.5256 0.6615 0.4487 ANK3/PAK1/ADORA1/HSPA5/PEX19/RPS5/TRAM2/RPL18/SEC63/RPLP0/ITGB2/RPL13 12 BP GO:0010799 regulation of peptidyl-threonine phosphorylation 3/1096 47/18670 0.5265 0.662 0.449 CHI3L1/DDIT4/PLK1 3 BP GO:0042461 photoreceptor cell development 3/1096 47/18670 0.5265 0.662 0.449 VEGFA/THY1/DIO3 3 BP GO:0045023 G0 to G1 transition 3/1096 47/18670 0.5265 0.662 0.449 PCGF2/EHMT2/RING1 3 BP GO:0048066 developmental pigmentation 3/1096 47/18670 0.5265 0.662 0.449 ENPP1/RAB27A/GNA11 3 BP GO:0072527 pyrimidine-containing compound metabolic process 6/1096 99/18670 0.528 0.6638 0.4502 ALDH6A1/DCK/NME3/AGPAT1/TYMP/TK2 6 BP GO:0034644 cellular response to UV 5/1096 82/18670 0.531 0.6667 0.4522 MFAP4/ERCC1/AQP1/MAPK13/HYAL1 5 BP GO:0007006 mitochondrial membrane organization 8/1096 134/18670 0.5324 0.6667 0.4522 GZMB/HK2/NOL3/PINK1/ZNF205/BAD/BNIP3/PPP3CC 8 BP GO:0018210 peptidyl-threonine modification 8/1096 134/18670 0.5324 0.6667 0.4522 CDK10/PRKCB/CDC42BPA/CHI3L1/CLK1/DYRK2/DDIT4/PLK1 8 BP GO:0000027 ribosomal large subunit assembly 2/1096 30/18670 0.5326 0.6667 0.4522 MDN1/RPLP0 2 BP GO:0000038 very long-chain fatty acid metabolic process 2/1096 30/18670 0.5326 0.6667 0.4522 TECR/SLC27A2 2 BP GO:0006362 transcription elongation from RNA polymerase I promoter 2/1096 30/18670 0.5326 0.6667 0.4522 POLR2E/POLR1C 2 BP GO:0006517 protein deglycosylation 2/1096 30/18670 0.5326 0.6667 0.4522 MAN2B2/RNF103 2 BP GO:0010586 miRNA metabolic process 2/1096 30/18670 0.5326 0.6667 0.4522 NFKB1/SND1 2 BP GO:0021696 cerebellar cortex morphogenesis 2/1096 30/18670 0.5326 0.6667 0.4522 SERPINE2/ZNF365 2 BP GO:0021772 olfactory bulb development 2/1096 30/18670 0.5326 0.6667 0.4522 SEMA3A/ATF5 2 BP GO:0038111 interleukin-7-mediated signaling pathway 2/1096 30/18670 0.5326 0.6667 0.4522 IL2RG/IL7R 2 BP GO:0045939 negative regulation of steroid metabolic process 2/1096 30/18670 0.5326 0.6667 0.4522 NFKB1/APOE 2 BP GO:0045948 positive regulation of translational initiation 2/1096 30/18670 0.5326 0.6667 0.4522 CCL5/RXRA 2 BP GO:0048147 negative regulation of fibroblast proliferation 2/1096 30/18670 0.5326 0.6667 0.4522 NUPR1/SFRP1 2 BP GO:0048265 response to pain 2/1096 30/18670 0.5326 0.6667 0.4522 GCH1/THBS4 2 BP GO:0061082 myeloid leukocyte cytokine production 2/1096 30/18670 0.5326 0.6667 0.4522 TGFB2/GAS6 2 BP GO:0071480 cellular response to gamma radiation 2/1096 30/18670 0.5326 0.6667 0.4522 CRYAB/HSPA5 2 BP GO:1903205 regulation of hydrogen peroxide-induced cell death 2/1096 30/18670 0.5326 0.6667 0.4522 TRAP1/PINK1 2 BP GO:1904292 regulation of ERAD pathway 2/1096 30/18670 0.5326 0.6667 0.4522 UBE2J1/HERPUD1 2 BP GO:1904893 negative regulation of STAT cascade 2/1096 30/18670 0.5326 0.6667 0.4522 INPP5F/PTPN2 2 BP GO:0043666 regulation of phosphoprotein phosphatase activity 7/1096 117/18670 0.5349 0.6686 0.4535 MAGI2/RGN/PTPRC/MGAT5/PPP1R2/NCKAP1L/PPP1R1A 7 BP GO:0000381 regulation of alternative mRNA splicing, via spliceosome 4/1096 65/18670 0.535 0.6686 0.4535 FAM172A/SAP18/SRSF8/SREK1 4 BP GO:0048663 neuron fate commitment 4/1096 65/18670 0.535 0.6686 0.4535 SIX1/NTRK3/GATA2/BMP4 4 BP GO:1903311 regulation of mRNA metabolic process 19/1096 324/18670 0.536 0.6686 0.4535 FTO/KHDRBS3/CIRBP/SNRPA/FAM172A/BTG2/HSPB1/CNOT1/SRPK3/SAP18/MYD88/PAF1/CCNB1/JMJD6/SRSF8/IGF2BP3/SREK1/CSDC2/SUPT5H 19 BP GO:0007269 neurotransmitter secretion 10/1096 169/18670 0.5362 0.6686 0.4535 STXBP1/STX11/PRKCB/SYT17/UNC13B/SNCG/RIMS3/PFN2/SLC18A2/ADCY1 10 BP GO:0002181 cytoplasmic translation 6/1096 100/18670 0.538 0.6686 0.4535 EEF2/RPL18/EIF3F/GSPT1/RPLP0/DRG2 6 BP GO:0010657 muscle cell apoptotic process 6/1096 100/18670 0.538 0.6686 0.4535 PDE1A/PTK2B/NUPR1/NOL3/HSPB6/BNIP3 6 BP GO:0022600 digestive system process 6/1096 100/18670 0.538 0.6686 0.4535 UGCG/RBP4/AQP1/SLC2A5/TYMP/CHRM3 6 BP GO:0036503 ERAD pathway 6/1096 100/18670 0.538 0.6686 0.4535 HSPA5/RNF103/UBE4B/UBE2J1/WFS1/HERPUD1 6 BP GO:0061640 cytoskeleton-dependent cytokinesis 6/1096 100/18670 0.538 0.6686 0.4535 ANK3/DCTN3/SPTBN1/MYH10/PLK1/JTB 6 BP GO:0090174 organelle membrane fusion 6/1096 100/18670 0.538 0.6686 0.4535 CORO1A/STXBP1/STX11/TAP1/TBC1D4/TAPBP 6 BP GO:0008542 visual learning 3/1096 48/18670 0.5409 0.6686 0.4535 MECP2/B4GALT2/HIF1A 3 BP GO:0043268 positive regulation of potassium ion transport 3/1096 48/18670 0.5409 0.6686 0.4535 ADORA1/AKAP9/FHL1 3 BP GO:0051150 regulation of smooth muscle cell differentiation 3/1096 48/18670 0.5409 0.6686 0.4535 MECP2/SMARCD3/BMP4 3 BP GO:0061014 positive regulation of mRNA catabolic process 3/1096 48/18670 0.5409 0.6686 0.4535 FTO/BTG2/CNOT1 3 BP GO:1903825 organic acid transmembrane transport 8/1096 135/18670 0.5409 0.6686 0.4535 SLC1A4/PRAF2/SLC23A2/RGS2/PDPN/AQP9/SLC7A8/SLC7A5 8 BP GO:1905039 carboxylic acid transmembrane transport 8/1096 135/18670 0.5409 0.6686 0.4535 SLC1A4/PRAF2/SLC23A2/RGS2/PDPN/AQP9/SLC7A8/SLC7A5 8 BP GO:0019933 cAMP-mediated signaling 11/1096 187/18670 0.5416 0.6686 0.4535 ADCY9/PLN/RGS2/PTHLH/ADCY6/MAPK7/PF4/CXCL10/PTGER2/S1PR4/ADCY1 11 BP GO:0046470 phosphatidylcholine metabolic process 5/1096 83/18670 0.5419 0.6686 0.4535 MECP2/PNPLA6/LIPC/APOC1/PLA2G15 5 BP GO:0099643 signal release from synapse 10/1096 170/18670 0.5438 0.6686 0.4535 STXBP1/STX11/PRKCB/SYT17/UNC13B/SNCG/RIMS3/PFN2/SLC18A2/ADCY1 10 BP GO:0045047 protein targeting to ER 7/1096 118/18670 0.544 0.6686 0.4535 HSPA5/RPS5/TRAM2/RPL18/SEC63/RPLP0/RPL13 7 BP GO:0000212 meiotic spindle organization 1/1096 13/18670 0.5447 0.6686 0.4535 ATRX 1 BP GO:0000722 telomere maintenance via recombination 1/1096 13/18670 0.5447 0.6686 0.4535 ERCC1 1 BP GO:0001845 phagolysosome assembly 1/1096 13/18670 0.5447 0.6686 0.4535 CORO1A 1 BP GO:0001867 complement activation, lectin pathway 1/1096 13/18670 0.5447 0.6686 0.4535 FCN1 1 BP GO:0002281 macrophage activation involved in immune response 1/1096 13/18670 0.5447 0.6686 0.4535 LBP 1 BP GO:0002430 complement receptor mediated signaling pathway 1/1096 13/18670 0.5447 0.6686 0.4535 C3AR1 1 BP GO:0005513 detection of calcium ion 1/1096 13/18670 0.5447 0.6686 0.4535 CASQ2 1 BP GO:0006553 lysine metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 CRYM 1 BP GO:0006707 cholesterol catabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 APOE 1 BP GO:0006995 cellular response to nitrogen starvation 1/1096 13/18670 0.5447 0.6686 0.4535 GABARAPL1 1 BP GO:0008298 intracellular mRNA localization 1/1096 13/18670 0.5447 0.6686 0.4535 CASC3 1 BP GO:0009313 oligosaccharide catabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 MAN2B2 1 BP GO:0009437 carnitine metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 CRAT 1 BP GO:0010454 negative regulation of cell fate commitment 1/1096 13/18670 0.5447 0.6686 0.4535 FZD7 1 BP GO:0010459 negative regulation of heart rate 1/1096 13/18670 0.5447 0.6686 0.4535 PLN 1 BP GO:0010940 positive regulation of necrotic cell death 1/1096 13/18670 0.5447 0.6686 0.4535 BNIP3 1 BP GO:0016024 CDP-diacylglycerol biosynthetic process 1/1096 13/18670 0.5447 0.6686 0.4535 AGPAT1 1 BP GO:0016127 sterol catabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 APOE 1 BP GO:0019511 peptidyl-proline hydroxylation 1/1096 13/18670 0.5447 0.6686 0.4535 CRTAP 1 BP GO:0019627 urea metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 ASS1 1 BP GO:0021681 cerebellar granular layer development 1/1096 13/18670 0.5447 0.6686 0.4535 SERPINE2 1 BP GO:0021978 telencephalon regionalization 1/1096 13/18670 0.5447 0.6686 0.4535 BMP4 1 BP GO:0030007 cellular potassium ion homeostasis 1/1096 13/18670 0.5447 0.6686 0.4535 ATP4B 1 BP GO:0030205 dermatan sulfate metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 UST 1 BP GO:0030497 fatty acid elongation 1/1096 13/18670 0.5447 0.6686 0.4535 TECR 1 BP GO:0031274 positive regulation of pseudopodium assembly 1/1096 13/18670 0.5447 0.6686 0.4535 CCR7 1 BP GO:0031650 regulation of heat generation 1/1096 13/18670 0.5447 0.6686 0.4535 IL1B 1 BP GO:0032488 Cdc42 protein signal transduction 1/1096 13/18670 0.5447 0.6686 0.4535 APOE 1 BP GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/1096 13/18670 0.5447 0.6686 0.4535 CNOT1 1 BP GO:0034214 protein hexamerization 1/1096 13/18670 0.5447 0.6686 0.4535 UGDH 1 BP GO:0034969 histone arginine methylation 1/1096 13/18670 0.5447 0.6686 0.4535 CARM1 1 BP GO:0035563 positive regulation of chromatin binding 1/1096 13/18670 0.5447 0.6686 0.4535 MBD2 1 BP GO:0035641 locomotory exploration behavior 1/1096 13/18670 0.5447 0.6686 0.4535 APOE 1 BP GO:0038007 netrin-activated signaling pathway 1/1096 13/18670 0.5447 0.6686 0.4535 UNC5C 1 BP GO:0042635 positive regulation of hair cycle 1/1096 13/18670 0.5447 0.6686 0.4535 TGFB2 1 BP GO:0042711 maternal behavior 1/1096 13/18670 0.5447 0.6686 0.4535 MBD2 1 BP GO:0042761 very long-chain fatty acid biosynthetic process 1/1096 13/18670 0.5447 0.6686 0.4535 TECR 1 BP GO:0043116 negative regulation of vascular permeability 1/1096 13/18670 0.5447 0.6686 0.4535 ANGPT1 1 BP GO:0043562 cellular response to nitrogen levels 1/1096 13/18670 0.5447 0.6686 0.4535 GABARAPL1 1 BP GO:0043970 histone H3-K9 acetylation 1/1096 13/18670 0.5447 0.6686 0.4535 GATA3 1 BP GO:0046349 amino sugar biosynthetic process 1/1096 13/18670 0.5447 0.6686 0.4535 GFPT1 1 BP GO:0048505 regulation of timing of cell differentiation 1/1096 13/18670 0.5447 0.6686 0.4535 SERPINE2 1 BP GO:0048715 negative regulation of oligodendrocyte differentiation 1/1096 13/18670 0.5447 0.6686 0.4535 ID4 1 BP GO:0050746 regulation of lipoprotein metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 ITGAV 1 BP GO:0050872 white fat cell differentiation 1/1096 13/18670 0.5447 0.6686 0.4535 FABP4 1 BP GO:0051001 negative regulation of nitric-oxide synthase activity 1/1096 13/18670 0.5447 0.6686 0.4535 CAV3 1 BP GO:0060312 regulation of blood vessel remodeling 1/1096 13/18670 0.5447 0.6686 0.4535 ABR 1 BP GO:0060712 spongiotrophoblast layer development 1/1096 13/18670 0.5447 0.6686 0.4535 PHLDA2 1 BP GO:0060746 parental behavior 1/1096 13/18670 0.5447 0.6686 0.4535 MBD2 1 BP GO:0061000 negative regulation of dendritic spine development 1/1096 13/18670 0.5447 0.6686 0.4535 PLK2 1 BP GO:0070071 proton-transporting two-sector ATPase complex assembly 1/1096 13/18670 0.5447 0.6686 0.4535 TM9SF4 1 BP GO:0070103 regulation of interleukin-6-mediated signaling pathway 1/1096 13/18670 0.5447 0.6686 0.4535 PTPN2 1 BP GO:0070914 UV-damage excision repair 1/1096 13/18670 0.5447 0.6686 0.4535 ERCC1 1 BP GO:0071285 cellular response to lithium ion 1/1096 13/18670 0.5447 0.6686 0.4535 FABP4 1 BP GO:0071287 cellular response to manganese ion 1/1096 13/18670 0.5447 0.6686 0.4535 HSPA5 1 BP GO:0071872 cellular response to epinephrine stimulus 1/1096 13/18670 0.5447 0.6686 0.4535 ADIPOQ 1 BP GO:0090239 regulation of histone H4 acetylation 1/1096 13/18670 0.5447 0.6686 0.4535 AUTS2 1 BP GO:0090399 replicative senescence 1/1096 13/18670 0.5447 0.6686 0.4535 SERPINE1 1 BP GO:0097152 mesenchymal cell apoptotic process 1/1096 13/18670 0.5447 0.6686 0.4535 HIF1A 1 BP GO:0099633 protein localization to postsynaptic specialization membrane 1/1096 13/18670 0.5447 0.6686 0.4535 DAG1 1 BP GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 1/1096 13/18670 0.5447 0.6686 0.4535 DAG1 1 BP GO:1902306 negative regulation of sodium ion transmembrane transport 1/1096 13/18670 0.5447 0.6686 0.4535 NEDD4L 1 BP GO:1902855 regulation of non-motile cilium assembly 1/1096 13/18670 0.5447 0.6686 0.4535 MAP4 1 BP GO:1903726 negative regulation of phospholipid metabolic process 1/1096 13/18670 0.5447 0.6686 0.4535 APOC1 1 BP GO:1903960 negative regulation of anion transmembrane transport 1/1096 13/18670 0.5447 0.6686 0.4535 RGS2 1 BP GO:1904293 negative regulation of ERAD pathway 1/1096 13/18670 0.5447 0.6686 0.4535 UBE2J1 1 BP GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/1096 13/18670 0.5447 0.6686 0.4535 SFRP1 1 BP GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 1/1096 13/18670 0.5447 0.6686 0.4535 PARP3 1 BP GO:0006261 DNA-dependent DNA replication 9/1096 153/18670 0.5464 0.6706 0.4548 HMGA1/ZNF365/REV3L/ATRX/FGFR1/PURA/SLBP/PRIM2/CDC6 9 BP GO:0015800 acidic amino acid transport 4/1096 66/18670 0.5473 0.6709 0.4551 STXBP1/ADORA1/PRAF2/UNC13B 4 BP GO:0040014 regulation of multicellular organism growth 4/1096 66/18670 0.5473 0.6709 0.4551 FTO/CDK4/DIO3/LGMN 4 BP GO:0048207 vesicle targeting, rough ER to cis-Golgi 4/1096 66/18670 0.5473 0.6709 0.4551 TGFA/SERPINA1/CTSC/F8 4 BP GO:0048208 COPII vesicle coating 4/1096 66/18670 0.5473 0.6709 0.4551 TGFA/SERPINA1/CTSC/F8 4 BP GO:1901607 alpha-amino acid biosynthetic process 4/1096 66/18670 0.5473 0.6709 0.4551 ASS1/GOT2/BCAT1/GOT1 4 BP GO:0006363 termination of RNA polymerase I transcription 2/1096 31/18670 0.5505 0.6729 0.4564 POLR2E/POLR1C 2 BP GO:0006482 protein demethylation 2/1096 31/18670 0.5505 0.6729 0.4564 JMJD6/JARID2 2 BP GO:0006506 GPI anchor biosynthetic process 2/1096 31/18670 0.5505 0.6729 0.4564 GPAA1/PGAP2 2 BP GO:0007143 female meiotic nuclear division 2/1096 31/18670 0.5505 0.6729 0.4564 CDC25B/PLK1 2 BP GO:0008214 protein dealkylation 2/1096 31/18670 0.5505 0.6729 0.4564 JMJD6/JARID2 2 BP GO:0009394 2'-deoxyribonucleotide metabolic process 2/1096 31/18670 0.5505 0.6729 0.4564 ADA/GUK1 2 BP GO:0009954 proximal/distal pattern formation 2/1096 31/18670 0.5505 0.6729 0.4564 HOXA10/HOXA11 2 BP GO:0010762 regulation of fibroblast migration 2/1096 31/18670 0.5505 0.6729 0.4564 DDR2/PAK1 2 BP GO:0021988 olfactory lobe development 2/1096 31/18670 0.5505 0.6729 0.4564 SEMA3A/ATF5 2 BP GO:0045879 negative regulation of smoothened signaling pathway 2/1096 31/18670 0.5505 0.6729 0.4564 SERPINE2/ENPP1 2 BP GO:0045880 positive regulation of smoothened signaling pathway 2/1096 31/18670 0.5505 0.6729 0.4564 DLG5/SFRP1 2 BP GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 2/1096 31/18670 0.5505 0.6729 0.4564 ADCY9/PLN 2 BP GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/1096 31/18670 0.5505 0.6729 0.4564 CD44/CXCL12 2 BP GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/1096 31/18670 0.5505 0.6729 0.4564 CD44/PTTG1IP 2 BP GO:0006910 phagocytosis, recognition 5/1096 84/18670 0.5527 0.6753 0.458 TRBC1/FCN1/IGKC/JMJD6/IGLC1 5 BP GO:0046889 positive regulation of lipid biosynthetic process 5/1096 84/18670 0.5527 0.6753 0.458 ZBTB20/IL1B/RGN/ABCG1/APOE 5 BP GO:0055067 monovalent inorganic cation homeostasis 9/1096 154/18670 0.5544 0.6771 0.4593 MAPK3/ADORA1/NEDD4L/PDK2/TM9SF4/ATP4B/AGTR1/C7/ATP6V0D1 9 BP GO:0002534 cytokine production involved in inflammatory response 3/1096 49/18670 0.555 0.6778 0.4597 GPSM3/MYD88/IL17RA 3 BP GO:0034248 regulation of cellular amide metabolic process 28/1096 483/18670 0.5559 0.6788 0.4604 CCL5/FTO/BIN1/PTK2B/CIRBP/EEF2/MAPK3/BTG2/HSPB1/PTAFR/CNOT1/RGS2/PDK2/ABCG1/UPF3A/TRAP1/PIN1/PINK1/CDK4/EEF1A2/PURA/IGFBP5/APOE/IGF2BP3/CASC3/PA2G4/RXRA/POLDIP3 28 BP GO:0006958 complement activation, classical pathway 8/1096 137/18670 0.5579 0.681 0.4619 TRBC1/IGKC/CFI/IGLV6-57/C6/APCS/IGLC1/C7 8 BP GO:0019748 secondary metabolic process 4/1096 67/18670 0.5593 0.6823 0.4628 AKR1B1/PAM/AKR7A2/AKR1B10 4 BP GO:0051705 multi-organism behavior 4/1096 67/18670 0.5593 0.6823 0.4628 MECP2/SHANK2/CX3CR1/VPS13A 4 BP GO:2000573 positive regulation of DNA biosynthetic process 4/1096 67/18670 0.5593 0.6823 0.4628 PTK2B/PARM1/MAPK3/MAP3K4 4 BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 7/1096 120/18670 0.5621 0.6846 0.4644 UPF3A/RPS5/RPL18/GSPT1/RPLP0/CASC3/RPL13 7 BP GO:0072384 organelle transport along microtubule 5/1096 85/18670 0.5634 0.6846 0.4644 RASGRP1/KIF3B/HIF1A/UCHL1/TRIM58 5 BP GO:0009308 amine metabolic process 8/1096 138/18670 0.5662 0.6846 0.4644 MAOA/MECP2/AOC3/HPRT1/HDC/MOXD1/NQO1/ITGB2 8 BP GO:0051983 regulation of chromosome segregation 6/1096 103/18670 0.5673 0.6846 0.4644 ATRX/PTTG1/CCNB1/SPAG5/PLK1/CDC6 6 BP GO:0002323 natural killer cell activation involved in immune response 2/1096 32/18670 0.568 0.6846 0.4644 CORO1A/RAB27A 2 BP GO:0006505 GPI anchor metabolic process 2/1096 32/18670 0.568 0.6846 0.4644 GPAA1/PGAP2 2 BP GO:0008608 attachment of spindle microtubules to kinetochore 2/1096 32/18670 0.568 0.6846 0.4644 CCNB1/SPAG5 2 BP GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/1096 32/18670 0.568 0.6846 0.4644 PLN/CASQ2 2 BP GO:0031297 replication fork processing 2/1096 32/18670 0.568 0.6846 0.4644 ZNF365/ATRX 2 BP GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 2/1096 32/18670 0.568 0.6846 0.4644 FZD2/PHB 2 BP GO:0046685 response to arsenic-containing substance 2/1096 32/18670 0.568 0.6846 0.4644 DAXX/MAPK13 2 BP GO:0050779 RNA destabilization 2/1096 32/18670 0.568 0.6846 0.4644 TNFRSF1B/FTO 2 BP GO:0061311 cell surface receptor signaling pathway involved in heart development 2/1096 32/18670 0.568 0.6846 0.4644 BMP4/BMPR1A 2 BP GO:1901976 regulation of cell cycle checkpoint 2/1096 32/18670 0.568 0.6846 0.4644 CCNB1/CUL4A 2 BP GO:0009948 anterior/posterior axis specification 3/1096 50/18670 0.5689 0.6846 0.4644 BMP4/ETS2/BASP1 3 BP GO:0042398 cellular modified amino acid biosynthetic process 3/1096 50/18670 0.5689 0.6846 0.4644 GCH1/PLSCR1/CKMT2 3 BP GO:0045540 regulation of cholesterol biosynthetic process 3/1096 50/18670 0.5689 0.6846 0.4644 ABCG1/PMVK/APOE 3 BP GO:0106118 regulation of sterol biosynthetic process 3/1096 50/18670 0.5689 0.6846 0.4644 ABCG1/PMVK/APOE 3 BP GO:0006333 chromatin assembly or disassembly 11/1096 191/18670 0.5702 0.6846 0.4644 NAP1L3/HMGA1/KAT6B/TSPYL4/ATRX/SMARCA1/DAXX/PAF1/SMARCD3/HIRIP3/TSPYL2 11 BP GO:0008380 RNA splicing 27/1096 469/18670 0.5708 0.6846 0.4644 NOVA1/HTATSF1/KHDRBS3/CIRBP/SNRPA/FAM172A/AKAP17A/NOL3/SRPK3/DDX39A/SAP18/CLK1/POLR2E/JMJD6/PCBP2/SRSF8/PSIP1/SCAF8/PRPF8/CDC40/POLR2I/CASC3/SART1/SREK1/FASTK/TFIP11/SNRPD2 27 BP GO:0001771 immunological synapse formation 1/1096 14/18670 0.5714 0.6846 0.4644 CCR7 1 BP GO:0006241 CTP biosynthetic process 1/1096 14/18670 0.5714 0.6846 0.4644 NME3 1 BP GO:0007100 mitotic centrosome separation 1/1096 14/18670 0.5714 0.6846 0.4644 KIF3B 1 BP GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/1096 14/18670 0.5714 0.6846 0.4644 ATP4B 1 BP GO:0010752 regulation of cGMP-mediated signaling 1/1096 14/18670 0.5714 0.6846 0.4644 PTK2B 1 BP GO:0010867 positive regulation of triglyceride biosynthetic process 1/1096 14/18670 0.5714 0.6846 0.4644 RGN 1 BP GO:0010917 negative regulation of mitochondrial membrane potential 1/1096 14/18670 0.5714 0.6846 0.4644 BNIP3 1 BP GO:0010935 regulation of macrophage cytokine production 1/1096 14/18670 0.5714 0.6846 0.4644 TGFB2 1 BP GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/1096 14/18670 0.5714 0.6846 0.4644 CSK 1 BP GO:0020027 hemoglobin metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 HIF1A 1 BP GO:0021781 glial cell fate commitment 1/1096 14/18670 0.5714 0.6846 0.4644 NFE2L1 1 BP GO:0031272 regulation of pseudopodium assembly 1/1096 14/18670 0.5714 0.6846 0.4644 CCR7 1 BP GO:0032048 cardiolipin metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 MECP2 1 BP GO:0032310 prostaglandin secretion 1/1096 14/18670 0.5714 0.6846 0.4644 IL1B 1 BP GO:0032785 negative regulation of DNA-templated transcription, elongation 1/1096 14/18670 0.5714 0.6846 0.4644 SUPT5H 1 BP GO:0032802 low-density lipoprotein particle receptor catabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 APOE 1 BP GO:0034331 cell junction maintenance 1/1096 14/18670 0.5714 0.6846 0.4644 F2R 1 BP GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 1/1096 14/18670 0.5714 0.6846 0.4644 NAMPT 1 BP GO:0035020 regulation of Rac protein signal transduction 1/1096 14/18670 0.5714 0.6846 0.4644 AUTS2 1 BP GO:0035810 positive regulation of urine volume 1/1096 14/18670 0.5714 0.6846 0.4644 BTC 1 BP GO:0038166 angiotensin-activated signaling pathway 1/1096 14/18670 0.5714 0.6846 0.4644 AGTR1 1 BP GO:0040034 regulation of development, heterochronic 1/1096 14/18670 0.5714 0.6846 0.4644 SERPINE2 1 BP GO:0042487 regulation of odontogenesis of dentin-containing tooth 1/1096 14/18670 0.5714 0.6846 0.4644 BMP4 1 BP GO:0043144 snoRNA processing 1/1096 14/18670 0.5714 0.6846 0.4644 FBL 1 BP GO:0044090 positive regulation of vacuole organization 1/1096 14/18670 0.5714 0.6846 0.4644 PIP4K2B 1 BP GO:0044546 NLRP3 inflammasome complex assembly 1/1096 14/18670 0.5714 0.6846 0.4644 NLRP3 1 BP GO:0045198 establishment of epithelial cell apical/basal polarity 1/1096 14/18670 0.5714 0.6846 0.4644 TCF15 1 BP GO:0045836 positive regulation of meiotic nuclear division 1/1096 14/18670 0.5714 0.6846 0.4644 PLCB1 1 BP GO:0046036 CTP metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 NME3 1 BP GO:0046341 CDP-diacylglycerol metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 AGPAT1 1 BP GO:0046479 glycosphingolipid catabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 NAGA 1 BP GO:0046940 nucleoside monophosphate phosphorylation 1/1096 14/18670 0.5714 0.6846 0.4644 AK1 1 BP GO:0048266 behavioral response to pain 1/1096 14/18670 0.5714 0.6846 0.4644 THBS4 1 BP GO:0048308 organelle inheritance 1/1096 14/18670 0.5714 0.6846 0.4644 MAPK3 1 BP GO:0048313 Golgi inheritance 1/1096 14/18670 0.5714 0.6846 0.4644 MAPK3 1 BP GO:0050667 homocysteine metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 TST 1 BP GO:0051712 positive regulation of killing of cells of other organism 1/1096 14/18670 0.5714 0.6846 0.4644 BAD 1 BP GO:0051775 response to redox state 1/1096 14/18670 0.5714 0.6846 0.4644 ARHGDIB 1 BP GO:0051917 regulation of fibrinolysis 1/1096 14/18670 0.5714 0.6846 0.4644 SERPINE1 1 BP GO:0055064 chloride ion homeostasis 1/1096 14/18670 0.5714 0.6846 0.4644 CA12 1 BP GO:0060049 regulation of protein glycosylation 1/1096 14/18670 0.5714 0.6846 0.4644 IL15 1 BP GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/1096 14/18670 0.5714 0.6846 0.4644 PIN1 1 BP GO:0070307 lens fiber cell development 1/1096 14/18670 0.5714 0.6846 0.4644 TMOD1 1 BP GO:0071361 cellular response to ethanol 1/1096 14/18670 0.5714 0.6846 0.4644 CCL7 1 BP GO:0071391 cellular response to estrogen stimulus 1/1096 14/18670 0.5714 0.6846 0.4644 SFRP1 1 BP GO:0071941 nitrogen cycle metabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 ASS1 1 BP GO:0072425 signal transduction involved in G2 DNA damage checkpoint 1/1096 14/18670 0.5714 0.6846 0.4644 PLK1 1 BP GO:0090128 regulation of synapse maturation 1/1096 14/18670 0.5714 0.6846 0.4644 CLSTN1 1 BP GO:0090231 regulation of spindle checkpoint 1/1096 14/18670 0.5714 0.6846 0.4644 CCNB1 1 BP GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/1096 14/18670 0.5714 0.6846 0.4644 CCNB1 1 BP GO:0097154 GABAergic neuron differentiation 1/1096 14/18670 0.5714 0.6846 0.4644 GATA2 1 BP GO:0098543 detection of other organism 1/1096 14/18670 0.5714 0.6846 0.4644 TLR2 1 BP GO:0099171 presynaptic modulation of chemical synaptic transmission 1/1096 14/18670 0.5714 0.6846 0.4644 PRKCB 1 BP GO:0099188 postsynaptic cytoskeleton organization 1/1096 14/18670 0.5714 0.6846 0.4644 MYH10 1 BP GO:1903054 negative regulation of extracellular matrix organization 1/1096 14/18670 0.5714 0.6846 0.4644 TNFRSF1B 1 BP GO:1903504 regulation of mitotic spindle checkpoint 1/1096 14/18670 0.5714 0.6846 0.4644 CCNB1 1 BP GO:1903624 regulation of DNA catabolic process 1/1096 14/18670 0.5714 0.6846 0.4644 RGN 1 BP GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/1096 14/18670 0.5714 0.6846 0.4644 UBE2J1 1 BP GO:1904889 regulation of excitatory synapse assembly 1/1096 14/18670 0.5714 0.6846 0.4644 NTRK3 1 BP GO:1905050 positive regulation of metallopeptidase activity 1/1096 14/18670 0.5714 0.6846 0.4644 MAPK3 1 BP GO:1905516 positive regulation of fertilization 1/1096 14/18670 0.5714 0.6846 0.4644 PLCB1 1 BP GO:1905651 regulation of artery morphogenesis 1/1096 14/18670 0.5714 0.6846 0.4644 AKT3 1 BP GO:2001044 regulation of integrin-mediated signaling pathway 1/1096 14/18670 0.5714 0.6846 0.4644 EMP2 1 BP GO:2001212 regulation of vasculogenesis 1/1096 14/18670 0.5714 0.6846 0.4644 EMP2 1 BP GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/1096 14/18670 0.5714 0.6846 0.4644 IL1B 1 BP GO:1903363 negative regulation of cellular protein catabolic process 5/1096 86/18670 0.5739 0.6875 0.4663 NELL1/LAMP3/CAMLG/UBE2J1/USP7 5 BP GO:0051588 regulation of neurotransmitter transport 8/1096 139/18670 0.5745 0.688 0.4667 STXBP1/PRKCB/RGS2/UNC13B/SNCG/RIMS3/PFN2/ADCY1 8 BP GO:0009416 response to light stimulus 18/1096 314/18670 0.5764 0.6901 0.4681 MECP2/EGFR/MFAP4/CIRBP/SIK1/MAP3K4/GNA11/CCND1/B4GALT2/ERCC1/HIF1A/GPX1/AQP1/UBE4B/MAPK10/MAPK13/ELANE/HYAL1 18 BP GO:0072599 establishment of protein localization to endoplasmic reticulum 7/1096 122/18670 0.5798 0.6941 0.4708 HSPA5/RPS5/TRAM2/RPL18/SEC63/RPLP0/RPL13 7 BP GO:0006323 DNA packaging 12/1096 210/18670 0.5806 0.6949 0.4713 NAP1L3/HMGA1/KAT6B/TSPYL4/ATRX/SMARCA1/DAXX/PAF1/CCNB1/TTN/TSPYL2/TNP2 12 BP GO:0030071 regulation of mitotic metaphase/anaphase transition 3/1096 51/18670 0.5825 0.6969 0.4727 CCNB1/PLK1/CDC6 3 BP GO:2001258 negative regulation of cation channel activity 3/1096 51/18670 0.5825 0.6969 0.4727 ANK3/CASQ2/KCNAB1 3 BP GO:0035725 sodium ion transmembrane transport 8/1096 140/18670 0.5827 0.6969 0.4727 ANK3/FXYD1/NEDD4L/SLC20A1/ATP4B/SLC20A2/CAV3/SNTA1 8 BP GO:0015909 long-chain fatty acid transport 4/1096 69/18670 0.5829 0.6969 0.4727 FABP4/NMB/SLC27A2/APOE 4 BP GO:0051865 protein autoubiquitination 4/1096 69/18670 0.5829 0.6969 0.4727 SASH1/UBE4B/CNOT4/TRIM58 4 BP GO:0048477 oogenesis 5/1096 87/18670 0.5843 0.6981 0.4735 PTK2B/CDC25B/ERCC1/CCNB1/INHBB 5 BP GO:0016486 peptide hormone processing 2/1096 33/18670 0.5849 0.6981 0.4735 CPA3/NGF 2 BP GO:0018279 protein N-linked glycosylation via asparagine 2/1096 33/18670 0.5849 0.6981 0.4735 MGAT5/UBE2J1 2 BP GO:0019692 deoxyribose phosphate metabolic process 2/1096 33/18670 0.5849 0.6981 0.4735 ADA/GUK1 2 BP GO:0042339 keratan sulfate metabolic process 2/1096 33/18670 0.5849 0.6981 0.4735 B4GALT2/HEXA 2 BP GO:0042755 eating behavior 2/1096 33/18670 0.5849 0.6981 0.4735 UCHL1/TCF15 2 BP GO:0048536 spleen development 2/1096 33/18670 0.5849 0.6981 0.4735 NFKB2/JARID2 2 BP GO:2001038 regulation of cellular response to drug 2/1096 33/18670 0.5849 0.6981 0.4735 TRAP1/PINK1 2 BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 6/1096 105/18670 0.5863 0.6996 0.4745 RPS5/TRAM2/RPL18/SEC63/RPLP0/RPL13 6 BP GO:0006901 vesicle coating 4/1096 70/18670 0.5944 0.704 0.4775 TGFA/SERPINA1/CTSC/F8 4 BP GO:0043044 ATP-dependent chromatin remodeling 5/1096 88/18670 0.5946 0.704 0.4775 SMARCA1/HDAC1/ZNHIT1/TNP2/MBD2 5 BP GO:1902476 chloride transmembrane transport 5/1096 88/18670 0.5946 0.704 0.4775 GABRB1/CLIC5/FXYD1/SLC1A4/GLRB 5 BP GO:0050885 neuromuscular process controlling balance 3/1096 52/18670 0.5958 0.704 0.4775 MYH10/ABR/CAMTA1 3 BP GO:0051438 regulation of ubiquitin-protein transferase activity 3/1096 52/18670 0.5958 0.704 0.4775 PIN1/PINK1/PLK1 3 BP GO:0099518 vesicle cytoskeletal trafficking 3/1096 52/18670 0.5958 0.704 0.4775 RASGRP1/FNBP1L/KIF3B 3 BP GO:2000677 regulation of transcription regulatory region DNA binding 3/1096 52/18670 0.5958 0.704 0.4775 GATA3/TWIST1/FOXC1 3 BP GO:0001325 formation of extrachromosomal circular DNA 1/1096 15/18670 0.5966 0.704 0.4775 ERCC1 1 BP GO:0001711 endodermal cell fate commitment 1/1096 15/18670 0.5966 0.704 0.4775 PAF1 1 BP GO:0006098 pentose-phosphate shunt 1/1096 15/18670 0.5966 0.704 0.4775 PGD 1 BP GO:0006491 N-glycan processing 1/1096 15/18670 0.5966 0.704 0.4775 GANAB 1 BP GO:0007216 G protein-coupled glutamate receptor signaling pathway 1/1096 15/18670 0.5966 0.704 0.4775 HOMER3 1 BP GO:0007351 tripartite regional subdivision 1/1096 15/18670 0.5966 0.704 0.4775 BASP1 1 BP GO:0008595 anterior/posterior axis specification, embryo 1/1096 15/18670 0.5966 0.704 0.4775 BASP1 1 BP GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 1/1096 15/18670 0.5966 0.704 0.4775 NME3 1 BP GO:0009263 deoxyribonucleotide biosynthetic process 1/1096 15/18670 0.5966 0.704 0.4775 GUK1 1 BP GO:0010273 detoxification of copper ion 1/1096 15/18670 0.5966 0.704 0.4775 MT1G 1 BP GO:0010561 negative regulation of glycoprotein biosynthetic process 1/1096 15/18670 0.5966 0.704 0.4775 HBEGF 1 BP GO:0018216 peptidyl-arginine methylation 1/1096 15/18670 0.5966 0.704 0.4775 CARM1 1 BP GO:0019321 pentose metabolic process 1/1096 15/18670 0.5966 0.704 0.4775 PGD 1 BP GO:0019471 4-hydroxyproline metabolic process 1/1096 15/18670 0.5966 0.704 0.4775 GOT2 1 BP GO:0031573 intra-S DNA damage checkpoint 1/1096 15/18670 0.5966 0.704 0.4775 MDC1 1 BP GO:0032239 regulation of nucleobase-containing compound transport 1/1096 15/18670 0.5966 0.704 0.4775 ADORA1 1 BP GO:0032274 gonadotropin secretion 1/1096 15/18670 0.5966 0.704 0.4775 INHBB 1 BP GO:0032988 ribonucleoprotein complex disassembly 1/1096 15/18670 0.5966 0.704 0.4775 TFIP11 1 BP GO:0033151 V(D)J recombination 1/1096 15/18670 0.5966 0.704 0.4775 TCF7 1 BP GO:0034380 high-density lipoprotein particle assembly 1/1096 15/18670 0.5966 0.704 0.4775 APOE 1 BP GO:0035067 negative regulation of histone acetylation 1/1096 15/18670 0.5966 0.704 0.4775 TWIST1 1 BP GO:0042074 cell migration involved in gastrulation 1/1096 15/18670 0.5966 0.704 0.4775 AMOT 1 BP GO:0042762 regulation of sulfur metabolic process 1/1096 15/18670 0.5966 0.704 0.4775 PDK2 1 BP GO:0043249 erythrocyte maturation 1/1096 15/18670 0.5966 0.704 0.4775 TRIM58 1 BP GO:0043584 nose development 1/1096 15/18670 0.5966 0.704 0.4775 SIX1 1 BP GO:0043652 engulfment of apoptotic cell 1/1096 15/18670 0.5966 0.704 0.4775 RHOBTB1 1 BP GO:0045837 negative regulation of membrane potential 1/1096 15/18670 0.5966 0.704 0.4775 BNIP3 1 BP GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly 1/1096 15/18670 0.5966 0.704 0.4775 THRA 1 BP GO:0046321 positive regulation of fatty acid oxidation 1/1096 15/18670 0.5966 0.704 0.4775 TWIST1 1 BP GO:0048070 regulation of developmental pigmentation 1/1096 15/18670 0.5966 0.704 0.4775 GNA11 1 BP GO:0050651 dermatan sulfate proteoglycan biosynthetic process 1/1096 15/18670 0.5966 0.704 0.4775 UST 1 BP GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 1/1096 15/18670 0.5966 0.704 0.4775 CASQ2 1 BP GO:0051299 centrosome separation 1/1096 15/18670 0.5966 0.704 0.4775 KIF3B 1 BP GO:0060026 convergent extension 1/1096 15/18670 0.5966 0.704 0.4775 SFRP1 1 BP GO:0060339 negative regulation of type I interferon-mediated signaling pathway 1/1096 15/18670 0.5966 0.704 0.4775 PTPN2 1 BP GO:0072148 epithelial cell fate commitment 1/1096 15/18670 0.5966 0.704 0.4775 PDPN 1 BP GO:0090656 t-circle formation 1/1096 15/18670 0.5966 0.704 0.4775 ERCC1 1 BP GO:0090737 telomere maintenance via telomere trimming 1/1096 15/18670 0.5966 0.704 0.4775 ERCC1 1 BP GO:1900029 positive regulation of ruffle assembly 1/1096 15/18670 0.5966 0.704 0.4775 COBL 1 BP GO:1900119 positive regulation of execution phase of apoptosis 1/1096 15/18670 0.5966 0.704 0.4775 DLC1 1 BP GO:1902187 negative regulation of viral release from host cell 1/1096 15/18670 0.5966 0.704 0.4775 MID2 1 BP GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 1/1096 15/18670 0.5966 0.704 0.4775 BIN1 1 BP GO:1902969 mitotic DNA replication 1/1096 15/18670 0.5966 0.704 0.4775 FGFR1 1 BP GO:1903543 positive regulation of exosomal secretion 1/1096 15/18670 0.5966 0.704 0.4775 SDC1 1 BP GO:1990169 stress response to copper ion 1/1096 15/18670 0.5966 0.704 0.4775 MT1G 1 BP GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1/1096 15/18670 0.5966 0.704 0.4775 SFRP1 1 BP GO:2001256 regulation of store-operated calcium entry 1/1096 15/18670 0.5966 0.704 0.4775 HOMER3 1 BP GO:0007043 cell-cell junction assembly 7/1096 124/18670 0.5972 0.7042 0.4776 ARL2/TLN2/CDH5/DLG5/PECAM1/PRKCH/CDH2 7 BP GO:0046717 acid secretion 7/1096 124/18670 0.5972 0.7042 0.4776 ABCC3/STXBP1/IL1B/ADORA1/NMB/AQP9/UNC13B 7 BP GO:0048284 organelle fusion 7/1096 124/18670 0.5972 0.7042 0.4776 CORO1A/STXBP1/STX11/TAP1/TBC1D4/TAPBP/BNIP3 7 BP GO:0042180 cellular ketone metabolic process 14/1096 248/18670 0.5992 0.7063 0.4791 ADIPOQ/IL1B/AKR1B1/ADIPOR2/RGN/GOT2/PDK2/OXCT1/APOC1/AKR7A2/NQO1/NFE2L1/AKR1B10/TWIST1 14 BP GO:1901991 negative regulation of mitotic cell cycle phase transition 14/1096 248/18670 0.5992 0.7063 0.4791 BTG2/CCND1/CNOT1/CDKN2C/NACC2/PLK2/CDK4/CCNB1/CNOT4/CARM1/PLK1/CCL2/FHL1/CDC6 14 BP GO:0007094 mitotic spindle assembly checkpoint 2/1096 34/18670 0.6013 0.7067 0.4794 CCNB1/PLK1 2 BP GO:0010765 positive regulation of sodium ion transport 2/1096 34/18670 0.6013 0.7067 0.4794 ANK3/FXYD1 2 BP GO:0010984 regulation of lipoprotein particle clearance 2/1096 34/18670 0.6013 0.7067 0.4794 APOC1/CSK 2 BP GO:0018196 peptidyl-asparagine modification 2/1096 34/18670 0.6013 0.7067 0.4794 MGAT5/UBE2J1 2 BP GO:0031577 spindle checkpoint 2/1096 34/18670 0.6013 0.7067 0.4794 CCNB1/PLK1 2 BP GO:0032212 positive regulation of telomere maintenance via telomerase 2/1096 34/18670 0.6013 0.7067 0.4794 MAPK3/MAP3K4 2 BP GO:0032892 positive regulation of organic acid transport 2/1096 34/18670 0.6013 0.7067 0.4794 STXBP1/IL1B 2 BP GO:0036474 cell death in response to hydrogen peroxide 2/1096 34/18670 0.6013 0.7067 0.4794 TRAP1/PINK1 2 BP GO:0048048 embryonic eye morphogenesis 2/1096 34/18670 0.6013 0.7067 0.4794 EFEMP1/TWIST1 2 BP GO:0048665 neuron fate specification 2/1096 34/18670 0.6013 0.7067 0.4794 SIX1/NTRK3 2 BP GO:0071173 spindle assembly checkpoint 2/1096 34/18670 0.6013 0.7067 0.4794 CCNB1/PLK1 2 BP GO:0071174 mitotic spindle checkpoint 2/1096 34/18670 0.6013 0.7067 0.4794 CCNB1/PLK1 2 BP GO:0097009 energy homeostasis 2/1096 34/18670 0.6013 0.7067 0.4794 FOXO1/AMPD3 2 BP GO:0140115 export across plasma membrane 2/1096 34/18670 0.6013 0.7067 0.4794 FXYD1/ATP4B 2 BP GO:0006497 protein lipidation 5/1096 89/18670 0.6047 0.7106 0.482 UGCG/GPAA1/PGAP2/WDR45/PPM1A 5 BP GO:0033692 cellular polysaccharide biosynthetic process 4/1096 71/18670 0.6057 0.7114 0.4825 PPP1R3C/ENPP1/INSR/DYRK2 4 BP GO:0044786 cell cycle DNA replication 4/1096 71/18670 0.6057 0.7114 0.4825 ATRX/FGFR1/SLBP/PRIM2 4 BP GO:0006606 protein import into nucleus 8/1096 143/18670 0.6069 0.7128 0.4834 ANGPT1/SMAD3/ZIC1/NFKBIA/PKIG/HCLS1/BMP4/PTTG1IP 8 BP GO:1901988 negative regulation of cell cycle phase transition 15/1096 267/18670 0.6076 0.7134 0.4839 BTG2/CCND1/CNOT1/CDKN2C/NACC2/PLK2/CDK4/CCNB1/CNOT4/CARM1/PLK1/CCL2/FHL1/ATF5/CDC6 15 BP GO:0010970 transport along microtubule 9/1096 161/18670 0.6084 0.714 0.4843 RASGRP1/KIF3B/HSPB1/DST/HIF1A/UCHL1/PURA/ICK/TRIM58 9 BP GO:0099111 microtubule-based transport 9/1096 161/18670 0.6084 0.714 0.4843 RASGRP1/KIF3B/HSPB1/DST/HIF1A/UCHL1/PURA/ICK/TRIM58 9 BP GO:0000387 spliceosomal snRNP assembly 3/1096 53/18670 0.6089 0.714 0.4843 PRPF8/SART1/SNRPD2 3 BP GO:0007632 visual behavior 3/1096 53/18670 0.6089 0.714 0.4843 MECP2/B4GALT2/HIF1A 3 BP GO:0010043 response to zinc ion 3/1096 53/18670 0.6089 0.714 0.4843 PLN/ASS1/MT1G 3 BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3/1096 53/18670 0.6089 0.714 0.4843 CCNB1/PLK1/CDC6 3 BP GO:0030004 cellular monovalent inorganic cation homeostasis 6/1096 108/18670 0.614 0.7172 0.4865 MAPK3/NEDD4L/TM9SF4/ATP4B/C7/ATP6V0D1 6 BP GO:0099565 chemical synaptic transmission, postsynaptic 6/1096 108/18670 0.614 0.7172 0.4865 MECP2/PTK2B/SHANK2/ADORA1/UNC13B/GLRB 6 BP GO:0009953 dorsal/ventral pattern formation 5/1096 90/18670 0.6147 0.7172 0.4865 BMP4/BMPR1A/SFRP1/HOXA11/SMAD6 5 BP GO:0000723 telomere maintenance 9/1096 162/18670 0.6159 0.7172 0.4865 ZNF365/ATRX/MAPK3/MAP3K4/ERCC1/PARP3/USP7/PRIM2/TFIP11 9 BP GO:0015718 monocarboxylic acid transport 9/1096 162/18670 0.6159 0.7172 0.4865 ABCC3/FABP4/IL1B/GOT2/NMB/AQP9/SLC27A2/APOE/RXRA 9 BP GO:0006305 DNA alkylation 4/1096 72/18670 0.6168 0.7172 0.4865 MECP2/ATRX/EHMT2/MBD2 4 BP GO:0006306 DNA methylation 4/1096 72/18670 0.6168 0.7172 0.4865 MECP2/ATRX/EHMT2/MBD2 4 BP GO:0019226 transmission of nerve impulse 4/1096 72/18670 0.6168 0.7172 0.4865 ANK3/NTRK3/S1PR1/TYMP 4 BP GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/1096 72/18670 0.6168 0.7172 0.4865 LAMP3/CAMLG/UBE2J1/USP7 4 BP GO:0030705 cytoskeleton-dependent intracellular transport 10/1096 180/18670 0.6171 0.7172 0.4865 RASGRP1/FNBP1L/KIF3B/HSPB1/DST/HIF1A/UCHL1/PURA/ICK/TRIM58 10 BP GO:0006369 termination of RNA polymerase II transcription 2/1096 35/18670 0.6172 0.7172 0.4865 SLBP/SCAF8 2 BP GO:0009262 deoxyribonucleotide metabolic process 2/1096 35/18670 0.6172 0.7172 0.4865 ADA/GUK1 2 BP GO:0021955 central nervous system neuron axonogenesis 2/1096 35/18670 0.6172 0.7172 0.4865 NFIB/DCLK1 2 BP GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/1096 35/18670 0.6172 0.7172 0.4865 CAMLG/USP7 2 BP GO:0045070 positive regulation of viral genome replication 2/1096 35/18670 0.6172 0.7172 0.4865 CCL5/VAPA 2 BP GO:0060251 regulation of glial cell proliferation 2/1096 35/18670 0.6172 0.7172 0.4865 IL1B/PRKCH 2 BP GO:0000075 cell cycle checkpoint 12/1096 216/18670 0.6201 0.7172 0.4865 MDC1/TP53BP1/BTG2/CCND1/CNOT1/PLK2/CCNB1/CNOT4/CARM1/PLK1/CUL4A/CDC6 12 BP GO:0000076 DNA replication checkpoint 1/1096 16/18670 0.6203 0.7172 0.4865 CDC6 1 BP GO:0001732 formation of cytoplasmic translation initiation complex 1/1096 16/18670 0.6203 0.7172 0.4865 EIF3F 1 BP GO:0002295 T-helper cell lineage commitment 1/1096 16/18670 0.6203 0.7172 0.4865 BATF 1 BP GO:0006047 UDP-N-acetylglucosamine metabolic process 1/1096 16/18670 0.6203 0.7172 0.4865 GFPT1 1 BP GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/1096 16/18670 0.6203 0.7172 0.4865 PDK2 1 BP GO:0006837 serotonin transport 1/1096 16/18670 0.6203 0.7172 0.4865 SLC18A2 1 BP GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/1096 16/18670 0.6203 0.7172 0.4865 NME3 1 BP GO:0010225 response to UV-C 1/1096 16/18670 0.6203 0.7172 0.4865 MAP3K4 1 BP GO:0015074 DNA integration 1/1096 16/18670 0.6203 0.7172 0.4865 ZNF91 1 BP GO:0019377 glycolipid catabolic process 1/1096 16/18670 0.6203 0.7172 0.4865 NAGA 1 BP GO:0021542 dentate gyrus development 1/1096 16/18670 0.6203 0.7172 0.4865 BTG2 1 BP GO:0030252 growth hormone secretion 1/1096 16/18670 0.6203 0.7172 0.4865 LTBP4 1 BP GO:0030952 establishment or maintenance of cytoskeleton polarity 1/1096 16/18670 0.6203 0.7172 0.4865 AQP1 1 BP GO:0031269 pseudopodium assembly 1/1096 16/18670 0.6203 0.7172 0.4865 CCR7 1 BP GO:0032225 regulation of synaptic transmission, dopaminergic 1/1096 16/18670 0.6203 0.7172 0.4865 PINK1 1 BP GO:0032305 positive regulation of icosanoid secretion 1/1096 16/18670 0.6203 0.7172 0.4865 IL1B 1 BP GO:0034975 protein folding in endoplasmic reticulum 1/1096 16/18670 0.6203 0.7172 0.4865 HSPA5 1 BP GO:0035461 vitamin transmembrane transport 1/1096 16/18670 0.6203 0.7172 0.4865 SLC23A2 1 BP GO:0043981 histone H4-K5 acetylation 1/1096 16/18670 0.6203 0.7172 0.4865 JADE2 1 BP GO:0043982 histone H4-K8 acetylation 1/1096 16/18670 0.6203 0.7172 0.4865 JADE2 1 BP GO:0044827 modulation by host of viral genome replication 1/1096 16/18670 0.6203 0.7172 0.4865 VAPA 1 BP GO:0045116 protein neddylation 1/1096 16/18670 0.6203 0.7172 0.4865 UBA3 1 BP GO:0045623 negative regulation of T-helper cell differentiation 1/1096 16/18670 0.6203 0.7172 0.4865 IL4R 1 BP GO:0046325 negative regulation of glucose import 1/1096 16/18670 0.6203 0.7172 0.4865 ENPP1 1 BP GO:0048820 hair follicle maturation 1/1096 16/18670 0.6203 0.7172 0.4865 TGFB2 1 BP GO:0050655 dermatan sulfate proteoglycan metabolic process 1/1096 16/18670 0.6203 0.7172 0.4865 UST 1 BP GO:0050774 negative regulation of dendrite morphogenesis 1/1096 16/18670 0.6203 0.7172 0.4865 ID1 1 BP GO:0051238 sequestering of metal ion 1/1096 16/18670 0.6203 0.7172 0.4865 S100A9 1 BP GO:0051503 adenine nucleotide transport 1/1096 16/18670 0.6203 0.7172 0.4865 SLC25A4 1 BP GO:0051571 positive regulation of histone H3-K4 methylation 1/1096 16/18670 0.6203 0.7172 0.4865 AUTS2 1 BP GO:0051923 sulfation 1/1096 16/18670 0.6203 0.7172 0.4865 UST 1 BP GO:0060413 atrial septum morphogenesis 1/1096 16/18670 0.6203 0.7172 0.4865 TGFB2 1 BP GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/1096 16/18670 0.6203 0.7172 0.4865 GAS1 1 BP GO:0061684 chaperone-mediated autophagy 1/1096 16/18670 0.6203 0.7172 0.4865 EEF1A2 1 BP GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/1096 16/18670 0.6203 0.7172 0.4865 TM9SF4 1 BP GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/1096 16/18670 0.6203 0.7172 0.4865 CAMTA1 1 BP GO:0071545 inositol phosphate catabolic process 1/1096 16/18670 0.6203 0.7172 0.4865 NUDT3 1 BP GO:0071871 response to epinephrine 1/1096 16/18670 0.6203 0.7172 0.4865 ADIPOQ 1 BP GO:0072488 ammonium transmembrane transport 1/1096 16/18670 0.6203 0.7172 0.4865 AQP1 1 BP GO:0090083 regulation of inclusion body assembly 1/1096 16/18670 0.6203 0.7172 0.4865 SACS 1 BP GO:0090335 regulation of brown fat cell differentiation 1/1096 16/18670 0.6203 0.7172 0.4865 FTO 1 BP GO:0099116 tRNA 5'-end processing 1/1096 16/18670 0.6203 0.7172 0.4865 RPP40 1 BP GO:0106058 positive regulation of calcineurin-mediated signaling 1/1096 16/18670 0.6203 0.7172 0.4865 CAMTA1 1 BP GO:1902004 positive regulation of amyloid-beta formation 1/1096 16/18670 0.6203 0.7172 0.4865 ABCG1 1 BP GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/1096 16/18670 0.6203 0.7172 0.4865 CD44 1 BP GO:1903541 regulation of exosomal secretion 1/1096 16/18670 0.6203 0.7172 0.4865 SDC1 1 BP GO:1903830 magnesium ion transmembrane transport 1/1096 16/18670 0.6203 0.7172 0.4865 NIPAL3 1 BP GO:1904294 positive regulation of ERAD pathway 1/1096 16/18670 0.6203 0.7172 0.4865 HERPUD1 1 BP GO:2000369 regulation of clathrin-dependent endocytosis 1/1096 16/18670 0.6203 0.7172 0.4865 SNAP91 1 BP GO:2000651 positive regulation of sodium ion transmembrane transporter activity 1/1096 16/18670 0.6203 0.7172 0.4865 ANK3 1 BP GO:2000846 regulation of corticosteroid hormone secretion 1/1096 16/18670 0.6203 0.7172 0.4865 AGTR1 1 BP GO:2001224 positive regulation of neuron migration 1/1096 16/18670 0.6203 0.7172 0.4865 SEMA3A 1 BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3/1096 54/18670 0.6216 0.7183 0.4872 CCNB1/PLK1/CDC6 3 BP GO:0070206 protein trimerization 3/1096 54/18670 0.6216 0.7183 0.4872 CD247/ADIPOQ/COL1A1 3 BP GO:0090329 regulation of DNA-dependent DNA replication 3/1096 54/18670 0.6216 0.7183 0.4872 ZNF365/ATRX/FGFR1 3 BP GO:0071426 ribonucleoprotein complex export from nucleus 7/1096 127/18670 0.6225 0.7192 0.4878 DDX39A/SLBP/CDC40/CASC3/NXF1/NUP210/POLDIP3 7 BP GO:0007605 sensory perception of sound 8/1096 145/18670 0.6226 0.7192 0.4878 SIX1/ICAM1/CLIC5/COL1A1/FGFR1/GPX1/CRYM/WFS1 8 BP GO:0006613 cotranslational protein targeting to membrane 6/1096 109/18670 0.623 0.7194 0.488 RPS5/TRAM2/RPL18/SEC63/RPLP0/RPL13 6 BP GO:0051170 import into nucleus 9/1096 163/18670 0.6232 0.7196 0.4881 ANGPT1/SMAD3/ZIC1/NFKBIA/PKIG/HCLS1/BMP4/SNRPD2/PTTG1IP 9 BP GO:0048814 regulation of dendrite morphogenesis 5/1096 91/18670 0.6245 0.7209 0.4889 SIPA1L1/CUX1/NEDD4L/ID1/PDLIM5 5 BP GO:0017038 protein import 11/1096 199/18670 0.6252 0.7216 0.4894 ANGPT1/SMAD3/ZIC1/NFKBIA/PEX19/PKIG/HCLS1/BMP4/APOE/ARHGEF5/PTTG1IP 11 BP GO:0043624 cellular protein complex disassembly 12/1096 217/18670 0.6264 0.7227 0.4902 TMOD1/SEMA5A/GSN/PLEK/SPTBN1/ASPH/CAPG/CAMSAP2/MRPS18B/GSPT1/STMN2/MRPL49 12 BP GO:0046474 glycerophospholipid biosynthetic process 12/1096 217/18670 0.6264 0.7227 0.4902 PTPN13/PIP4K2B/CPNE1/PLSCR1/PLCG2/SH3YL1/GPAA1/INPP5F/PGAP2/ARF3/INPP5D/AGPAT1 12 BP GO:0071824 protein-DNA complex subunit organization 16/1096 288/18670 0.6267 0.7227 0.4902 NAP1L3/HMGA1/KAT6B/TSPYL4/THRA/ATRX/SMARCA1/DAXX/PAF1/SMARCD3/ZNHIT1/CETN2/RAD23B/CUL4A/TSPYL2/TNP2 16 BP GO:0098656 anion transmembrane transport 16/1096 288/18670 0.6267 0.7227 0.4902 GABRB1/CLIC5/FXYD1/SLC1A4/PRAF2/SLC23A2/SLC20A1/PTAFR/RGS2/PDPN/AQP9/SLC7A8/SLC7A5/SLC20A2/LRRC8B/GLRB 16 BP GO:1903779 regulation of cardiac conduction 4/1096 73/18670 0.6277 0.7237 0.4909 FXYD1/CASQ2/ASPH/ATP2A1 4 BP GO:2001251 negative regulation of chromosome organization 8/1096 146/18670 0.6304 0.7267 0.4929 HMGA1/ATRX/PTTG1/ERCC1/CCNB1/JARID2/TWIST1/PLK1 8 BP GO:0071166 ribonucleoprotein complex localization 7/1096 128/18670 0.6307 0.7269 0.493 DDX39A/SLBP/CDC40/CASC3/NXF1/NUP210/POLDIP3 7 BP GO:0098739 import across plasma membrane 6/1096 110/18670 0.6319 0.7281 0.4938 RGS2/KCNJ8/SLC39A8/ATP4B/SLC39A14/SLC2A5 6 BP GO:0003417 growth plate cartilage development 2/1096 36/18670 0.6327 0.7284 0.494 STC1/CARM1 2 BP GO:0032733 positive regulation of interleukin-10 production 2/1096 36/18670 0.6327 0.7284 0.494 CD83/TLR2 2 BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/1096 36/18670 0.6327 0.7284 0.494 CCNB1/PLK1 2 BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 2/1096 36/18670 0.6327 0.7284 0.494 PLN/CASQ2 2 BP GO:0007601 visual perception 12/1096 218/18670 0.6328 0.7284 0.494 CLIC5/RBP4/CRX/ABLIM1/COL1A1/ATF6/EFEMP1/TIMP3/DHRS3/GLRB/LAMB2/WFS1 12 BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 3/1096 55/18670 0.6341 0.7293 0.4947 PINK1/NDUFB7/NDUFV1 3 BP GO:0042220 response to cocaine 3/1096 55/18670 0.6341 0.7293 0.4947 PTK2B/HSPA5/CCNA2 3 BP GO:0070830 bicellular tight junction assembly 3/1096 55/18670 0.6341 0.7293 0.4947 ARL2/PECAM1/PRKCH 3 BP GO:0097120 receptor localization to synapse 3/1096 55/18670 0.6341 0.7293 0.4947 CLSTN1/DAG1/MAPK10 3 BP GO:0031497 chromatin assembly 9/1096 165/18670 0.6378 0.731 0.4958 NAP1L3/HMGA1/KAT6B/TSPYL4/ATRX/SMARCA1/DAXX/PAF1/TSPYL2 9 BP GO:0048285 organelle fission 25/1096 449/18670 0.6379 0.731 0.4958 PLCB1/TGFA/ARHGEF10/KIF3B/ATRX/IL1B/CDC25B/BTC/PEX19/INSR/PTTG1/PIN1/PINK1/BMP4/NFE2L1/CCNB1/LRP5/TTN/MX2/SPAG5/TPX2/PLK1/SPICE1/BNIP3/CDC6 25 BP GO:0048199 vesicle targeting, to, from or within Golgi 4/1096 74/18670 0.6384 0.731 0.4958 TGFA/SERPINA1/CTSC/F8 4 BP GO:1900182 positive regulation of protein localization to nucleus 4/1096 74/18670 0.6384 0.731 0.4958 SMAD3/ZIC1/HCLS1/PLK1 4 BP GO:0018022 peptidyl-lysine methylation 7/1096 129/18670 0.6389 0.731 0.4958 EZH1/MECP2/GATA3/ATRX/AUTS2/EHMT2/JARID2 7 BP GO:0044106 cellular amine metabolic process 7/1096 129/18670 0.6389 0.731 0.4958 MAOA/MECP2/HPRT1/HDC/MOXD1/NQO1/ITGB2 7 BP GO:0000097 sulfur amino acid biosynthetic process 1/1096 17/18670 0.6426 0.731 0.4958 CDO1 1 BP GO:0002031 G protein-coupled receptor internalization 1/1096 17/18670 0.6426 0.731 0.4958 DNM1 1 BP GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 1/1096 17/18670 0.6426 0.731 0.4958 TGFB2 1 BP GO:0006089 lactate metabolic process 1/1096 17/18670 0.6426 0.731 0.4958 HIF1A 1 BP GO:0006544 glycine metabolic process 1/1096 17/18670 0.6426 0.731 0.4958 SDS 1 BP GO:0006577 amino-acid betaine metabolic process 1/1096 17/18670 0.6426 0.731 0.4958 CRAT 1 BP GO:0006825 copper ion transport 1/1096 17/18670 0.6426 0.731 0.4958 CP 1 BP GO:0006895 Golgi to endosome transport 1/1096 17/18670 0.6426 0.731 0.4958 VPS13A 1 BP GO:0007076 mitotic chromosome condensation 1/1096 17/18670 0.6426 0.731 0.4958 TTN 1 BP GO:0007635 chemosensory behavior 1/1096 17/18670 0.6426 0.731 0.4958 WFS1 1 BP GO:0008340 determination of adult lifespan 1/1096 17/18670 0.6426 0.731 0.4958 INPP5D 1 BP GO:0015693 magnesium ion transport 1/1096 17/18670 0.6426 0.731 0.4958 NIPAL3 1 BP GO:0015732 prostaglandin transport 1/1096 17/18670 0.6426 0.731 0.4958 IL1B 1 BP GO:0015868 purine ribonucleotide transport 1/1096 17/18670 0.6426 0.731 0.4958 SLC25A4 1 BP GO:0015919 peroxisomal membrane transport 1/1096 17/18670 0.6426 0.731 0.4958 PEX19 1 BP GO:0017121 phospholipid scrambling 1/1096 17/18670 0.6426 0.731 0.4958 PLSCR1 1 BP GO:0018027 peptidyl-lysine dimethylation 1/1096 17/18670 0.6426 0.731 0.4958 EHMT2 1 BP GO:0021514 ventral spinal cord interneuron differentiation 1/1096 17/18670 0.6426 0.731 0.4958 GATA2 1 BP GO:0031000 response to caffeine 1/1096 17/18670 0.6426 0.731 0.4958 CASQ2 1 BP GO:0031268 pseudopodium organization 1/1096 17/18670 0.6426 0.731 0.4958 CCR7 1 BP GO:0031649 heat generation 1/1096 17/18670 0.6426 0.731 0.4958 IL1B 1 BP GO:0032460 negative regulation of protein oligomerization 1/1096 17/18670 0.6426 0.731 0.4958 CRYAB 1 BP GO:0032966 negative regulation of collagen biosynthetic process 1/1096 17/18670 0.6426 0.731 0.4958 GOT1 1 BP GO:0035729 cellular response to hepatocyte growth factor stimulus 1/1096 17/18670 0.6426 0.731 0.4958 LGMN 1 BP GO:0035855 megakaryocyte development 1/1096 17/18670 0.6426 0.731 0.4958 PTPN6 1 BP GO:0035930 corticosteroid hormone secretion 1/1096 17/18670 0.6426 0.731 0.4958 AGTR1 1 BP GO:0036270 response to diuretic 1/1096 17/18670 0.6426 0.731 0.4958 CASQ2 1 BP GO:0038092 nodal signaling pathway 1/1096 17/18670 0.6426 0.731 0.4958 SMAD3 1 BP GO:0042953 lipoprotein transport 1/1096 17/18670 0.6426 0.731 0.4958 PRKCB 1 BP GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/1096 17/18670 0.6426 0.731 0.4958 BATF 1 BP GO:0044872 lipoprotein localization 1/1096 17/18670 0.6426 0.731 0.4958 PRKCB 1 BP GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/1096 17/18670 0.6426 0.731 0.4958 CXCL8 1 BP GO:0050665 hydrogen peroxide biosynthetic process 1/1096 17/18670 0.6426 0.731 0.4958 ZNF205 1 BP GO:0051284 positive regulation of sequestering of calcium ion 1/1096 17/18670 0.6426 0.731 0.4958 CASQ2 1 BP GO:0051969 regulation of transmission of nerve impulse 1/1096 17/18670 0.6426 0.731 0.4958 TYMP 1 BP GO:0060080 inhibitory postsynaptic potential 1/1096 17/18670 0.6426 0.731 0.4958 UNC13B 1 BP GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 1/1096 17/18670 0.6426 0.731 0.4958 BIN1 1 BP GO:0061687 detoxification of inorganic compound 1/1096 17/18670 0.6426 0.731 0.4958 MT1G 1 BP GO:0070166 enamel mineralization 1/1096 17/18670 0.6426 0.731 0.4958 FOXO1 1 BP GO:0071850 mitotic cell cycle arrest 1/1096 17/18670 0.6426 0.731 0.4958 MAGI2 1 BP GO:0097329 response to antimetabolite 1/1096 17/18670 0.6426 0.731 0.4958 ATRX 1 BP GO:0098856 intestinal lipid absorption 1/1096 17/18670 0.6426 0.731 0.4958 UGCG 1 BP GO:1901524 regulation of mitophagy 1/1096 17/18670 0.6426 0.731 0.4958 PINK1 1 BP GO:1902683 regulation of receptor localization to synapse 1/1096 17/18670 0.6426 0.731 0.4958 DAG1 1 BP GO:1904380 endoplasmic reticulum mannose trimming 1/1096 17/18670 0.6426 0.731 0.4958 RNF103 1 BP GO:1904948 midbrain dopaminergic neuron differentiation 1/1096 17/18670 0.6426 0.731 0.4958 SFRP1 1 BP GO:2000001 regulation of DNA damage checkpoint 1/1096 17/18670 0.6426 0.731 0.4958 CUL4A 1 BP GO:2000641 regulation of early endosome to late endosome transport 1/1096 17/18670 0.6426 0.731 0.4958 MAPK3 1 BP GO:2000811 negative regulation of anoikis 1/1096 17/18670 0.6426 0.731 0.4958 ITGA5 1 BP GO:0071103 DNA conformation change 18/1096 327/18670 0.6457 0.734 0.4978 NAP1L3/HMGA1/KAT6B/CHD9/TSPYL4/ATRX/SMARCA1/DAXX/PAF1/CCNB1/PURA/TTN/CETN2/G3BP1/RAD23B/CUL4A/TSPYL2/TNP2 18 BP GO:0044784 metaphase/anaphase transition of cell cycle 3/1096 56/18670 0.6463 0.734 0.4978 CCNB1/PLK1/CDC6 3 BP GO:0045292 mRNA cis splicing, via spliceosome 3/1096 56/18670 0.6463 0.734 0.4978 SRSF8/PSIP1/SART1 3 BP GO:0060113 inner ear receptor cell differentiation 3/1096 56/18670 0.6463 0.734 0.4978 FZD2/FGFR1/BMP4 3 BP GO:0065002 intracellular protein transmembrane transport 3/1096 56/18670 0.6463 0.734 0.4978 HSPA5/TRAM2/SEC63 3 BP GO:0070936 protein K48-linked ubiquitination 3/1096 56/18670 0.6463 0.734 0.4978 TNFAIP3/NEDD4L/NMI 3 BP GO:0120192 tight junction assembly 3/1096 56/18670 0.6463 0.734 0.4978 ARL2/PECAM1/PRKCH 3 BP GO:1902017 regulation of cilium assembly 3/1096 56/18670 0.6463 0.734 0.4978 DZIP1/CDK10/MAP4 3 BP GO:0006997 nucleus organization 7/1096 130/18670 0.6469 0.7343 0.4981 PRKCB/BIN1/NFE2L1/CCNB1/PLK1/TNP2/CCNB2 7 BP GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 2/1096 37/18670 0.6476 0.7343 0.4981 ERCC1/CUL4A 2 BP GO:0045777 positive regulation of blood pressure 2/1096 37/18670 0.6476 0.7343 0.4981 ADORA1/HSD11B2 2 BP GO:0046006 regulation of activated T cell proliferation 2/1096 37/18670 0.6476 0.7343 0.4981 IGFBP2/IL2RA 2 BP GO:0046839 phospholipid dephosphorylation 2/1096 37/18670 0.6476 0.7343 0.4981 INPP5F/INPP5D 2 BP GO:0086010 membrane depolarization during action potential 2/1096 37/18670 0.6476 0.7343 0.4981 ANK3/CAV3 2 BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/1096 37/18670 0.6476 0.7343 0.4981 CCNB1/PLK1 2 BP GO:1904358 positive regulation of telomere maintenance via telomere lengthening 2/1096 37/18670 0.6476 0.7343 0.4981 MAPK3/MAP3K4 2 BP GO:0006353 DNA-templated transcription, termination 4/1096 75/18670 0.6489 0.7355 0.4989 POLR2E/SLBP/SCAF8/POLR1C 4 BP GO:0015914 phospholipid transport 4/1096 75/18670 0.6489 0.7355 0.4989 ATP9A/ABCG1/APOC1/APOE 4 CC GO:0044449 contractile fiber part 49/1118 221/19717 9.574e-17 6.223e-14 5.069e-14 PARVA/SYNM/TMOD1/CRYAB/TPM2/SORBS2/PDLIM1/MYL6B/ANK3/SVIL/FLNB/TIMP4/BIN1/DAG1/ACTN1/TPM4/PAK1/DES/HSPB1/DST/TNNT1/MYL2/LDB3/SPTBN1/MYH11/CASQ2/TNNC2/MYH2/CSRP1/MYL9/MYOM2/MYH7/TNNC1/CAV3/MYL3/ACTA2/ACTA1/PDLIM4/TNNI1/PECAM1/TPM3/MYL1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1/ALDOA 49 CC GO:0043292 contractile fiber 50/1118 234/19717 2.325e-16 7.556e-14 6.155e-14 PARVA/CALD1/SYNM/TMOD1/CRYAB/TPM2/SORBS2/PDLIM1/MYL6B/ANK3/SVIL/FLNB/TIMP4/BIN1/DAG1/ACTN1/TPM4/PAK1/DES/HSPB1/DST/TNNT1/MYL2/LDB3/SPTBN1/MYH11/CASQ2/TNNC2/MYH2/CSRP1/MYL9/MYOM2/MYH7/TNNC1/CAV3/MYL3/ACTA2/ACTA1/PDLIM4/TNNI1/PECAM1/TPM3/MYL1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1/ALDOA 50 CC GO:0030016 myofibril 46/1118 224/19717 1.772e-14 3.839e-12 3.127e-12 PARVA/CALD1/SYNM/TMOD1/CRYAB/TPM2/SORBS2/PDLIM1/ANK3/SVIL/FLNB/TIMP4/BIN1/DAG1/ACTN1/TPM4/PAK1/DES/HSPB1/DST/TNNT1/MYL2/LDB3/SPTBN1/CASQ2/TNNC2/MYH2/CSRP1/MYL9/MYOM2/MYH7/TNNC1/CAV3/MYL3/ACTA1/PDLIM4/TNNI1/TPM3/MYL1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1/ALDOA 46 CC GO:0062023 collagen-containing extracellular matrix 65/1118 406/19717 2.593e-14 4.213e-12 3.432e-12 FCN1/SERPINE2/CPA3/ADAM19/RARRES2/ADAMDEC1/MXRA7/LOXL2/TGFB2/CDON/ADIPOQ/PXDN/ICAM1/MFAP4/SLPI/SERPINA1/THBS2/DAG1/MXRA5/POSTN/SULF1/IGFBP7/CTSD/MGP/DST/KAZALD1/TGM2/S100A9/FBLN5/CTSC/ANXA11/ADAMTS2/ADAMTS3/CTSL/CFP/PLSCR1/SPARCL1/COL1A1/TIMP2/CTSH/CTSF/SERPINB8/LTBP4/EFNA5/EFEMP2/EFEMP1/TIMP3/PF4/GPC5/HTRA1/APOE/SERPINE1/GDF10/CXCL12/THBS4/LAMB2/APCS/CDH2/SFRP1/LOXL1/PRG4/COL3A1/ELANE/COL4A1/PCOLCE 65 CC GO:0009897 external side of plasma membrane 63/1118 393/19717 6.159e-14 8.006e-12 6.522e-12 TRBC1/CD3D/FCN1/TGFBR3/SERPINE2/CXCR4/IL2RG/IL7R/IL2RB/IL11RA/ITGAV/ICAM1/CD226/ADA/MS4A2/CD8A/GFRA2/CD40/FCGR2B/DAG1/CD2/CCR7/S1PR1/FCGRT/SDC1/IL27RA/CCR5/PTPRC/CDH5/CD14/CD83/ABCG1/INSR/CD3G/CD27/CX3CR1/CCR2/THY1/CXCR6/ITGA5/EFNA5/PECAM1/TNFRSF4/IGKC/CCR6/LAG3/CXCL10/BMPR1A/CD86/CXCL12/TFRC/IGLC1/ITGB2/IL2RA/IL3RA/PDGFRA/LIFR/KLRD1/SELP/CSF2RA/CD69/CRLF1/AMOT 63 CC GO:0030017 sarcomere 42/1118 204/19717 2.238e-13 2.424e-11 1.975e-11 PARVA/TMOD1/CRYAB/TPM2/SORBS2/PDLIM1/ANK3/FLNB/TIMP4/BIN1/ACTN1/TPM4/PAK1/DES/HSPB1/DST/TNNT1/MYL2/LDB3/SPTBN1/CASQ2/TNNC2/MYH2/CSRP1/MYL9/MYOM2/MYH7/TNNC1/CAV3/MYL3/ACTA1/PDLIM4/TNNI1/TPM3/MYL1/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1/ALDOA 42 CC GO:0005925 focal adhesion 57/1118 405/19717 2.004e-10 1.861e-08 1.516e-08 DDR2/PARVA/RAC2/ITGB7/ARL2/SORBS2/GSN/HMGA1/ITGAV/PDLIM1/EGFR/MAPRE2/ICAM1/MDC1/SVIL/FLNB/LCP1/EPB41L2/PTK2B/DAG1/ACTN1/TPM4/PAK1/MAPK3/HSPB1/DST/FZD2/TLN2/TGM2/RALA/HSPA5/CD44/PTPRC/CSRP1/ITGA4/ARHGAP26/RPS5/ITGBL1/CAV3/THY1/DLC1/ITGA5/PLAUR/RPL18/PCBP2/NCKAP1/RPLP0/G3BP1/CTTN/ARPC3/LPXN/CDH2/ITGB2/FGFR3/STARD8/FHL1/FLT1 57 CC GO:0005924 cell-substrate adherens junction 57/1118 408/19717 2.672e-10 2.171e-08 1.769e-08 DDR2/PARVA/RAC2/ITGB7/ARL2/SORBS2/GSN/HMGA1/ITGAV/PDLIM1/EGFR/MAPRE2/ICAM1/MDC1/SVIL/FLNB/LCP1/EPB41L2/PTK2B/DAG1/ACTN1/TPM4/PAK1/MAPK3/HSPB1/DST/FZD2/TLN2/TGM2/RALA/HSPA5/CD44/PTPRC/CSRP1/ITGA4/ARHGAP26/RPS5/ITGBL1/CAV3/THY1/DLC1/ITGA5/PLAUR/RPL18/PCBP2/NCKAP1/RPLP0/G3BP1/CTTN/ARPC3/LPXN/CDH2/ITGB2/FGFR3/STARD8/FHL1/FLT1 57 CC GO:0030055 cell-substrate junction 57/1118 412/19717 3.9e-10 2.817e-08 2.294e-08 DDR2/PARVA/RAC2/ITGB7/ARL2/SORBS2/GSN/HMGA1/ITGAV/PDLIM1/EGFR/MAPRE2/ICAM1/MDC1/SVIL/FLNB/LCP1/EPB41L2/PTK2B/DAG1/ACTN1/TPM4/PAK1/MAPK3/HSPB1/DST/FZD2/TLN2/TGM2/RALA/HSPA5/CD44/PTPRC/CSRP1/ITGA4/ARHGAP26/RPS5/ITGBL1/CAV3/THY1/DLC1/ITGA5/PLAUR/RPL18/PCBP2/NCKAP1/RPLP0/G3BP1/CTTN/ARPC3/LPXN/CDH2/ITGB2/FGFR3/STARD8/FHL1/FLT1 57 CC GO:0045121 membrane raft 47/1118 315/19717 1.154e-09 7.502e-08 6.111e-08 TNFRSF1B/ANGPT1/EGFR/LCK/ICAM1/CD226/SGCA/EMP2/CD8A/PTK2B/CD48/BIRC3/DAG1/EEF2/RFTN1/CD2/SULF1/FXYD1/S1PR1/CTSD/MAPK3/SELPLG/PTPRC/NPC1/PDPN/CD14/LCP2/PLSCR1/INSR/TFPI/SKAP1/CAV3/F2R/THY1/DLC1/EFNA5/PECAM1/STOML1/TLR2/OLR1/BMPR1A/CSK/INPP5D/CDH2/ITGB2/ADCY1/LAT 47 CC GO:0098857 membrane microdomain 47/1118 316/19717 1.283e-09 7.582e-08 6.176e-08 TNFRSF1B/ANGPT1/EGFR/LCK/ICAM1/CD226/SGCA/EMP2/CD8A/PTK2B/CD48/BIRC3/DAG1/EEF2/RFTN1/CD2/SULF1/FXYD1/S1PR1/CTSD/MAPK3/SELPLG/PTPRC/NPC1/PDPN/CD14/LCP2/PLSCR1/INSR/TFPI/SKAP1/CAV3/F2R/THY1/DLC1/EFNA5/PECAM1/STOML1/TLR2/OLR1/BMPR1A/CSK/INPP5D/CDH2/ITGB2/ADCY1/LAT 47 CC GO:0098589 membrane region 47/1118 328/19717 4.392e-09 2.314e-07 1.885e-07 TNFRSF1B/ANGPT1/EGFR/LCK/ICAM1/CD226/SGCA/EMP2/CD8A/PTK2B/CD48/BIRC3/DAG1/EEF2/RFTN1/CD2/SULF1/FXYD1/S1PR1/CTSD/MAPK3/SELPLG/PTPRC/NPC1/PDPN/CD14/LCP2/PLSCR1/INSR/TFPI/SKAP1/CAV3/F2R/THY1/DLC1/EFNA5/PECAM1/STOML1/TLR2/OLR1/BMPR1A/CSK/INPP5D/CDH2/ITGB2/ADCY1/LAT 47 CC GO:0005865 striated muscle thin filament 13/1118 31/19717 4.628e-09 2.314e-07 1.885e-07 TMOD1/TPM2/TPM4/TNNT1/TNNC2/MYOM2/TNNC1/ACTA1/TNNI1/TPM3/TTN/MYBPC2/MYOM1 13 CC GO:0031674 I band 28/1118 143/19717 7.209e-09 3.202e-07 2.608e-07 PARVA/CRYAB/SORBS2/PDLIM1/ANK3/FLNB/BIN1/ACTN1/PAK1/DES/HSPB1/DST/LDB3/CASQ2/CSRP1/MYL9/MYOM2/MYH7/CAV3/MYL3/PDLIM4/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1/ALDOA 28 CC GO:0036379 myofilament 13/1118 32/19717 7.39e-09 3.202e-07 2.608e-07 TMOD1/TPM2/TPM4/TNNT1/TNNC2/MYOM2/TNNC1/ACTA1/TNNI1/TPM3/TTN/MYBPC2/MYOM1 13 CC GO:0005884 actin filament 24/1118 111/19717 1.118e-08 4.542e-07 3.7e-07 RAC2/SH2B2/TMOD1/CORO1A/TPM2/PDLIM1/LCP1/ACTN1/TPM4/PAK1/LDB3/HCLS1/ACTA1/PDLIM4/TPM3/MYO1B/NCKAP1/CTTN/ARPC3/PDLIM5/PSTPIP1/COBL/GNG12/AMOT 24 CC GO:0030667 secretory granule membrane 43/1118 298/19717 1.618e-08 6.186e-07 5.039e-07 TNFRSF1B/ADAM8/ITGAV/LILRB2/SLC2A3/ITGAX/CPNE1/MLEC/CYB5R1/LILRA3/ABCA3/ITGAL/PAM/APLP2/RAB27A/PTAFR/CD38/CD44/PTPRC/ICA1/CD14/SLC27A2/CD53/STXBP2/SYNGR1/ALDH3B1/LAMP3/STK10/MOXD1/PECAM1/PLAUR/FCGR2A/SELL/NCKAP1L/SLC2A5/TLR2/OLR1/LILRB3/ITGB2/C3AR1/NRAS/SELP/VAPA 43 CC GO:0030018 Z disc 26/1118 132/19717 2.169e-08 7.833e-07 6.381e-07 PARVA/CRYAB/SORBS2/PDLIM1/ANK3/FLNB/BIN1/ACTN1/PAK1/DES/HSPB1/DST/LDB3/CASQ2/CSRP1/MYL9/MYOM2/MYH7/CAV3/PDLIM4/TTN/MYBPC2/NEB/HDAC4/PDLIM5/MYOM1 26 CC GO:0042581 specific granule 29/1118 160/19717 2.411e-08 8.249e-07 6.719e-07 TNFRSF1B/ADAM8/ITGAV/SLC2A3/SLPI/MLEC/LILRA3/CTSD/PTPN6/ITGAL/RAB27A/NFKB1/ANXA11/CHI3L1/CXCL1/CFP/SLC27A2/CD53/QPCT/TIMP2/STXBP2/ALDH3B1/STK10/PLAUR/SLC2A5/OLR1/ITGB2/C3AR1/ELANE 29 CC GO:0031983 vesicle lumen 46/1118 339/19717 3.532e-08 1.148e-06 9.351e-07 FCN1/SRGN/RARRES2/HUWE1/HBB/TGFB2/VEGFA/GSN/EGFR/ADA/SLPI/SERPINA1/ACTN1/EEF2/MAGED2/CTSD/PTPN6/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PYGB/CHI3L1/AMPD3/CXCL1/CFP/QPCT/CFD/GAS6/TIMP2/CTSH/GMFG/TIMP3/PF4/F8/APOE/SERPINE1/GNLY/GCA/IMPDH1/IMPDH2/ALOX5/PA2G4/ELANE/ALDOA 46 CC GO:0060205 cytoplasmic vesicle lumen 45/1118 338/19717 8.765e-08 2.713e-06 2.21e-06 FCN1/SRGN/RARRES2/HUWE1/HBB/TGFB2/VEGFA/GSN/ADA/SLPI/SERPINA1/ACTN1/EEF2/MAGED2/CTSD/PTPN6/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PYGB/CHI3L1/AMPD3/CXCL1/CFP/QPCT/CFD/GAS6/TIMP2/CTSH/GMFG/TIMP3/PF4/F8/APOE/SERPINE1/GNLY/GCA/IMPDH1/IMPDH2/ALOX5/PA2G4/ELANE/ALDOA 45 CC GO:0031252 cell leading edge 50/1118 403/19717 1.623e-07 4.794e-06 3.905e-06 CXCR4/PARVA/RAC2/SH2B2/CORO1A/SORBS2/GSN/ITGAV/PTPN13/LCP1/CDC42BPA/PTK2B/DAG1/ACTN1/PSD3/PLEK/PAK1/ADORA1/DST/TLN2/SPTBN1/MYH10/CD44/PDPN/ABLIM1/INSR/GABARAPL1/CAPG/SH3YL1/SKAP1/KANK1/ACTA2/UNC5C/THY1/ACTA1/PDLIM4/DLC1/ITGA5/SLC39A14/NCKAP1/RAB22A/PDE9A/STMN2/CTTN/ARPC3/CDH2/PSTPIP1/COBL/PSD4/AMOT 50 CC GO:0031091 platelet alpha granule 19/1118 91/19717 6.581e-07 1.86e-05 1.515e-05 SERPINE2/SRGN/TGFB2/STXBP1/VEGFA/SERPINA1/THBS2/ACTN1/CYB5R1/MAGED2/APLP2/CFD/GAS6/PECAM1/PF4/F8/SERPINE1/SELP/ALDOA 19 CC GO:0034774 secretory granule lumen 41/1118 321/19717 9.819e-07 2.659e-05 2.166e-05 FCN1/SRGN/RARRES2/HUWE1/TGFB2/VEGFA/GSN/SLPI/SERPINA1/ACTN1/EEF2/MAGED2/CTSD/PTPN6/CYB5R3/S100A9/RAB27A/NFKB1/CTSC/PYGB/CHI3L1/AMPD3/CXCL1/CFP/QPCT/CFD/GAS6/TIMP2/CTSH/GMFG/TIMP3/PF4/F8/SERPINE1/GCA/IMPDH1/IMPDH2/ALOX5/PA2G4/ELANE/ALDOA 41 CC GO:0016460 myosin II complex 9/1118 22/19717 1.491e-06 3.876e-05 3.157e-05 MYL6B/MYH11/MYH10/MYH2/MYL9/MYH7/MYL3/MYL1/MYOM1 9 CC GO:0042641 actomyosin 17/1118 79/19717 1.623e-06 4.057e-05 3.305e-05 SH2B2/PDLIM1/FLNB/LCP1/CDC42BPA/ACTN1/TPM4/LDB3/MYH10/ABLIM1/MYL9/MYH7/ACTA1/PDLIM4/TPM3/HDAC4/PDLIM5 17 CC GO:0005859 muscle myosin complex 8/1118 18/19717 2.736e-06 6.588e-05 5.366e-05 MYL6B/MYH11/MYH2/MYL9/MYH7/MYL3/MYL1/MYOM1 8 CC GO:0001772 immunological synapse 11/1118 36/19717 2.997e-06 6.956e-05 5.667e-05 CORO1A/RHOH/GZMB/LCK/ICAM1/GZMA/CD53/CD37/SKAP1/DUSP3/LAT 11 CC GO:0032432 actin filament bundle 16/1118 75/19717 3.686e-06 8.21e-05 6.688e-05 SH2B2/CRYAB/PDLIM1/FLNB/LCP1/ACTN1/TPM4/LDB3/MYH10/ABLIM1/MYL9/MYH7/ACTA1/PDLIM4/TPM3/PDLIM5 16 CC GO:0001725 stress fiber 15/1118 67/19717 3.916e-06 8.21e-05 6.688e-05 SH2B2/PDLIM1/FLNB/LCP1/ACTN1/TPM4/LDB3/MYH10/ABLIM1/MYL9/MYH7/ACTA1/PDLIM4/TPM3/PDLIM5 15 CC GO:0097517 contractile actin filament bundle 15/1118 67/19717 3.916e-06 8.21e-05 6.688e-05 SH2B2/PDLIM1/FLNB/LCP1/ACTN1/TPM4/LDB3/MYH10/ABLIM1/MYL9/MYH7/ACTA1/PDLIM4/TPM3/PDLIM5 15 CC GO:0030027 lamellipodium 28/1118 193/19717 4.505e-06 9.151e-05 7.454e-05 PARVA/RAC2/CORO1A/SORBS2/GSN/ITGAV/PTPN13/CDC42BPA/PTK2B/DAG1/PAK1/MYH10/CD44/PDPN/ABLIM1/CAPG/ACTA2/UNC5C/ACTA1/PDLIM4/SLC39A14/NCKAP1/STMN2/CTTN/ARPC3/CDH2/PSTPIP1/AMOT 28 CC GO:0031672 A band 11/1118 39/19717 7.145e-06 0.0001407 0.0001146 CRYAB/DST/MYL2/SPTBN1/MYOM2/MYL3/TTN/MYBPC2/HDAC4/MYOM1/ALDOA 11 CC GO:0031594 neuromuscular junction 15/1118 76/19717 1.992e-05 0.0003808 0.0003102 SERPINE2/ANK3/SYNGR2/POSTN/DES/PDZRN3/MYH10/TRIP4/CAV3/SYNGR1/F2R/UNC13B/SNTA1/HDAC4/LAMB2 15 CC GO:0035579 specific granule membrane 16/1118 91/19717 4.78e-05 0.0008784 0.0007156 TNFRSF1B/ADAM8/ITGAV/SLC2A3/MLEC/LILRA3/ITGAL/SLC27A2/CD53/ALDH3B1/STK10/PLAUR/SLC2A5/OLR1/ITGB2/C3AR1 16 CC GO:0101002 ficolin-1-rich granule 25/1118 185/19717 4.865e-05 0.0008784 0.0007156 FCN1/ADAM8/HUWE1/TNFAIP6/HBB/GSN/LILRB2/SLC2A3/SERPINA1/ITGAX/EEF2/LILRA3/CTSD/AMPD3/QPCT/CFD/TIMP2/CTSH/GMFG/NCKAP1L/ITGB2/IMPDH1/IMPDH2/ALOX5/ALDOA 25 CC GO:0070820 tertiary granule 23/1118 164/19717 5.374e-05 0.0009441 0.000769 ADAM8/TNFAIP6/HBB/LILRB2/SLC2A3/ITGAX/LILRA3/CTSD/PTPN6/PTAFR/CXCL1/CFP/CD53/QPCT/TIMP2/METTL7A/STXBP2/CTSH/NCKAP1L/OLR1/ITGB2/NRAS/ALDOA 23 CC GO:0016459 myosin complex 13/1118 65/19717 6.085e-05 0.001041 0.0008479 MYL6B/MYL2/MYH11/MYH10/MYH2/MYL9/MYOM2/MYH7/MYL3/MYL1/MYO1B/MYBPC2/MYOM1 13 CC GO:0001726 ruffle 23/1118 172/19717 0.0001129 0.001881 0.001533 SH2B2/GSN/ITGAV/LCP1/ACTN1/PSD3/PLEK/PAK1/TLN2/PDPN/CAPG/SH3YL1/SKAP1/KANK1/DLC1/ITGA5/NCKAP1/RAB22A/PDE9A/CTTN/COBL/PSD4/AMOT 23 CC GO:0043025 neuronal cell body 49/1118 497/19717 0.0001191 0.001936 0.001577 TNFRSF1B/CRYAB/TGFB2/CD200/PDE1A/SLC2A3/FLNB/ADA/PTK2B/SHANK2/ADORA1/SLC1A4/PAM/ASS1/CBX6/GOT2/MYH10/KCNAB1/ITGA4/INSR/CX3CR1/TIMP2/OLFM1/CCR2/INPP5F/AKAP9/UNC5C/THY1/NRGN/SEMA4F/UCHL1/NQO1/EEF1A2/HDAC1/PURA/MAPK10/SNCG/APOE/KCNB2/PDE9A/STMN2/G3BP1/BMPR1A/PTPRF/KCNN3/TPX2/COBL/PVALB/NPTX2 49 CC GO:0033267 axon part 40/1118 382/19717 0.0001403 0.002225 0.001812 TNFRSF1B/ANK3/PRKCB/BIN1/PTK2B/KIF3B/DAG1/SHANK2/AUTS2/ADORA1/HSPB1/DST/CBX6/SPTBN1/MYH10/KCNAB1/ITGA4/DNM1/TIMP2/OLFM1/HIF1A/UNC5C/THY1/PINK1/UCHL1/GOT1/UNC13B/PCDH9/BASP1/STMN2/CTTN/ARPC3/TPX2/DCTN2/COBL/ATP6V0D1/NPTX2/CHRM3/SLC18A2/GAP43 40 CC GO:0032982 myosin filament 7/1118 22/19717 0.0001485 0.002298 0.001872 MYH11/MYH10/MYH2/MYOM2/MYH7/MYBPC2/MYOM1 7 CC GO:0045335 phagocytic vesicle 19/1118 132/19717 0.0001647 0.00249 0.002028 ADAM8/RAC2/CORO1A/STXBP1/GSN/ITGAV/TAP1/FLNB/ANXA11/STXBP2/RAPGEF1/UNC13B/TLR2/GNLY/RAB22A/TAPBP/NCF2/ELANE/ATP6V0D1 19 CC GO:0002102 podosome 8/1118 30/19717 0.0001989 0.002938 0.002394 ADAM8/GSN/SVIL/LCP1/TPM4/CTTN/ARHGEF5/LPXN 8 CC GO:1904813 ficolin-1-rich granule lumen 18/1118 124/19717 0.0002176 0.00313 0.00255 FCN1/HUWE1/TNFAIP6/HBB/GSN/SERPINA1/EEF2/CTSD/AMPD3/QPCT/CFD/TIMP2/CTSH/GMFG/IMPDH1/IMPDH2/ALOX5/ALDOA 18 CC GO:1904724 tertiary granule lumen 11/1118 55/19717 0.0002215 0.00313 0.00255 TNFAIP6/HBB/CTSD/PTPN6/CXCL1/CFP/QPCT/TIMP2/METTL7A/CTSH/ALDOA 11 CC GO:0005911 cell-cell junction 45/1118 459/19717 0.0002519 0.003451 0.002811 MAGI2/CORO1A/VEGFA/PDLIM1/ANK3/ITK/NDRG1/TMEM47/SGCA/CDC42BPA/CALB2/PPL/DAG1/CLDN7/ACTN1/AKR1B1/CD2/FXYD1/PAK1/STEAP1/DES/DNMBP/PTPN6/LDB3/CCND1/MXRA8/CDH5/LCP2/CD53/DLG5/SKAP1/CAV3/PDLIM4/ITGA5/PECAM1/CDK4/PCDH9/PDLIM5/CSK/AMOTL2/VAV1/CDH2/VAPA/LAT/AMOT 45 CC GO:0008305 integrin complex 8/1118 31/19717 0.0002549 0.003451 0.002811 ITGB7/ITGAV/ITGAX/ITGAL/ITGA4/ITGBL1/ITGA5/ITGB2 8 CC GO:0032994 protein-lipid complex 9/1118 39/19717 0.0002652 0.003518 0.002866 LPL/BIN1/HDLBP/LIPC/APOC1/PLA2G7/APOE/APOF/SAA4 9 CC GO:0031093 platelet alpha granule lumen 12/1118 67/19717 0.0003447 0.004481 0.00365 SRGN/TGFB2/VEGFA/SERPINA1/ACTN1/MAGED2/CFD/GAS6/PF4/F8/SERPINE1/ALDOA 12 CC GO:0000792 heterochromatin 13/1118 78/19717 0.0004127 0.005257 0.004282 MECP2/HMGA1/PCGF2/ATRX/CBX6/CBX1/HDAC1/IKZF1/CENPB/SATB1/FOXC1/RING1/MBD2 13 CC GO:0044853 plasma membrane raft 16/1118 109/19717 0.0004206 0.005257 0.004282 CD8A/DAG1/FXYD1/MAPK3/SELPLG/LCP2/INSR/TFPI/SKAP1/CAV3/F2R/DLC1/EFNA5/BMPR1A/CDH2/ITGB2 16 CC GO:0098636 protein complex involved in cell adhesion 8/1118 34/19717 0.0005041 0.006183 0.005036 ITGB7/ITGAV/ITGAX/ITGAL/ITGA4/ITGBL1/ITGA5/ITGB2 8 CC GO:0005720 nuclear heterochromatin 8/1118 35/19717 0.0006214 0.00748 0.006093 PCGF2/ATRX/CBX1/IKZF1/CENPB/SATB1/FOXC1/RING1 8 CC GO:0035580 specific granule lumen 11/1118 62/19717 0.0006547 0.007737 0.006303 SLPI/CTSD/PTPN6/RAB27A/NFKB1/CHI3L1/CXCL1/CFP/QPCT/TIMP2/ELANE 11 CC GO:0005788 endoplasmic reticulum lumen 32/1118 309/19717 0.0007553 0.00872 0.007103 SPP1/TSPAN5/SERPINA1/DAG1/IGFBP7/APLP2/CTSC/HSPA5/MXRA8/CASQ2/LIPC/CFP/SLC27A2/SPARCL1/COL1A1/GAS6/CRTAP/BMP4/CP/MINPP1/PLAUR/IGFBP5/F8/APOE/KTN1/LAMB2/GANAB/CDH2/WFS1/COL3A1/STS/COL4A1 32 CC GO:0031430 M band 7/1118 28/19717 0.0007647 0.00872 0.007103 CRYAB/SPTBN1/MYOM2/TTN/MYBPC2/MYOM1/ALDOA 7 CC GO:0030863 cortical cytoskeleton 16/1118 116/19717 0.0008456 0.009477 0.00772 CALD1/TMOD1/CORO1A/GSN/EPB41L2/CALB2/TPM4/SPTBN1/HCLS1/DLC1/GMFG/HIP1/RIMS3/CTTN/CDH2/PVALB 16 CC GO:0034358 plasma lipoprotein particle 8/1118 37/19717 0.0009217 0.009733 0.007929 LPL/HDLBP/LIPC/APOC1/PLA2G7/APOE/APOF/SAA4 8 CC GO:1990777 lipoprotein particle 8/1118 37/19717 0.0009217 0.009733 0.007929 LPL/HDLBP/LIPC/APOC1/PLA2G7/APOE/APOF/SAA4 8 CC GO:0042470 melanosome 15/1118 106/19717 0.0009284 0.009733 0.007929 GCHFR/CTSD/SLC1A4/RAB27A/ANXA11/MYH11/HSPA5/RAB29/CAPG/SYNGR1/AHCY/SND1/SGSM2/TFRC/GANAB 15 CC GO:0048770 pigment granule 15/1118 106/19717 0.0009284 0.009733 0.007929 GCHFR/CTSD/SLC1A4/RAB27A/ANXA11/MYH11/HSPA5/RAB29/CAPG/SYNGR1/AHCY/SND1/SGSM2/TFRC/GANAB 15 CC GO:1990752 microtubule end 7/1118 29/19717 0.0009592 0.009896 0.008061 MAPRE2/SVIL/DST/MAPRE3/SKAP1/CAMSAP2/SPAG5 7 CC GO:0030427 site of polarized growth 21/1118 176/19717 0.001021 0.01036 0.008443 PTK2B/SHANK2/AUTS2/CBX6/MYH10/ITGA4/HCLS1/TIMP2/OLFM1/UNC5C/THY1/PINK1/PCDH9/BASP1/STMN2/CTTN/ARPC3/DCTN2/COBL/NPTX2/GAP43 21 CC GO:0033643 host cell part 5/1118 16/19717 0.0015 0.015 0.01222 AXL/RAB29/GBP2/AQP1/PF4 5 CC GO:0033655 host cell cytoplasm part 4/1118 10/19717 0.001639 0.01594 0.01298 RAB29/GBP2/AQP1/PF4 4 CC GO:0030864 cortical actin cytoskeleton 13/1118 90/19717 0.001643 0.01594 0.01298 CALD1/CORO1A/GSN/EPB41L2/CALB2/SPTBN1/HCLS1/DLC1/GMFG/HIP1/CTTN/CDH2/PVALB 13 CC GO:0030426 growth cone 20/1118 171/19717 0.001695 0.0162 0.0132 PTK2B/SHANK2/AUTS2/CBX6/MYH10/ITGA4/TIMP2/OLFM1/UNC5C/THY1/PINK1/PCDH9/BASP1/STMN2/CTTN/ARPC3/DCTN2/COBL/NPTX2/GAP43 20 CC GO:0030665 clathrin-coated vesicle membrane 15/1118 115/19717 0.002138 0.02014 0.0164 CD3D/IL7R/TGFA/EGFR/NCALD/HBEGF/BTC/FZD2/CD3G/NRGN/AP1B1/HIP1/APOE/TFRC/SLC18A2 15 CC GO:0000307 cyclin-dependent protein kinase holoenzyme complex 8/1118 42/19717 0.002192 0.02036 0.01658 CDK14/CCND2/CKS1B/CCND1/CCNA2/CDK4/CCNB1/CCNB2 8 CC GO:0030430 host cell cytoplasm 4/1118 11/19717 0.00246 0.02252 0.01834 RAB29/GBP2/AQP1/PF4 4 CC GO:0034364 high-density lipoprotein particle 6/1118 26/19717 0.002833 0.02558 0.02083 HDLBP/LIPC/APOC1/APOE/APOF/SAA4 6 CC GO:0005635 nuclear envelope 41/1118 464/19717 0.00333 0.02965 0.02415 PLCB1/IL15RA/GRK5/GABRB1/RAC2/LTC4S/GCHFR/EGFR/PHLPP1/BIN1/PGRMC2/CPNE1/GPX4/SMAD3/PAK1/MAPK3/DST/CCND2/GCH1/NELL1/ANXA11/NPC1/SMAD1/INSR/ATF6/CDK4/AQP1/LBR/MX2/CETN2/LMNB1/DUSP2/CASC3/NXF1/UTP18/NUP210/BNIP3/PTGDS/ALOX5/TYRO3/VAPA 41 CC GO:0016010 dystrophin-associated glycoprotein complex 5/1118 19/19717 0.003464 0.03002 0.02446 SSPN/SGCA/DAG1/CAV3/SNTA1 5 CC GO:0090665 glycoprotein complex 5/1118 19/19717 0.003464 0.03002 0.02446 SSPN/SGCA/DAG1/CAV3/SNTA1 5 CC GO:0031256 leading edge membrane 19/1118 170/19717 0.003647 0.03119 0.02541 ITGAV/LCP1/PSD3/PLEK/PAK1/ADORA1/SPTBN1/CD44/PDPN/INSR/GABARAPL1/SH3YL1/KANK1/THY1/DLC1/ITGA5/NCKAP1/PDE9A/PSD4 19 CC GO:0035371 microtubule plus-end 5/1118 20/19717 0.004406 0.03719 0.0303 MAPRE2/DST/MAPRE3/SKAP1/SPAG5 5 CC GO:0005938 cell cortex 29/1118 308/19717 0.005244 0.0437 0.0356 CALD1/TMOD1/CORO1A/RHOH/GSN/FNBP1L/FLNB/EPB41L2/PTK2B/CALB2/RHOBTB3/CLIC5/GPSM2/TPM4/DST/SPTBN1/MYH10/ASPH/HCLS1/DLC1/UNC13B/GMFG/HIP1/RIMS3/FNBP1/CTTN/CDH2/COBL/PVALB 29 CC GO:0016323 basolateral plasma membrane 22/1118 217/19717 0.006046 0.04974 0.04052 P2RY6/TGFA/EGFR/ANK3/ENPP1/DAG1/CLDN7/ADORA1/DST/SLC23A2/CD38/CD44/SLC29A1/PDPN/AQP9/SLC7A8/AQP1/LPO/TFRC/CDH2/ST14/CHRM3 22 CC GO:0150034 distal axon 27/1118 285/19717 0.006367 0.05103 0.04157 PRKCB/PTK2B/SHANK2/AUTS2/ADORA1/CBX6/MYH10/ITGA4/TIMP2/OLFM1/UNC5C/THY1/PINK1/GOT1/UNC13B/PCDH9/BASP1/STMN2/CTTN/ARPC3/DCTN2/COBL/ATP6V0D1/NPTX2/CHRM3/SLC18A2/GAP43 27 CC GO:0033646 host intracellular part 4/1118 14/19717 0.00651 0.05103 0.04157 RAB29/GBP2/AQP1/PF4 4 CC GO:0043656 intracellular region of host 4/1118 14/19717 0.00651 0.05103 0.04157 RAB29/GBP2/AQP1/PF4 4 CC GO:0009898 cytoplasmic side of plasma membrane 17/1118 154/19717 0.006516 0.05103 0.04157 LITAF/RGS1/LCK/PTK2B/PTPN7/CD2/CBX6/GNA11/RGS2/PTPRC/ESYT1/KCNAB1/PTPN22/HIP1/TRAF3/GNG12/NPTX2 17 CC GO:0032587 ruffle membrane 12/1118 94/19717 0.006775 0.05209 0.04243 ITGAV/LCP1/PSD3/PLEK/PAK1/PDPN/SH3YL1/KANK1/DLC1/ITGA5/PDE9A/PSD4 12 CC GO:0042629 mast cell granule 5/1118 22/19717 0.006811 0.05209 0.04243 SRGN/RASGRP1/AKR1B1/S100A13/LAT 5 CC GO:0030139 endocytic vesicle 28/1118 303/19717 0.007699 0.05819 0.0474 ADAM8/RAC2/CORO1A/HBB/STXBP1/GSN/ITGAV/EGFR/TAP1/FLNB/HBEGF/FZD2/ANXA11/RALA/STXBP2/INPP5F/RAPGEF1/UNC13B/HIP1/TLR2/APOE/GNLY/RAB22A/TAPBP/NCF2/ELANE/ATP6V0D1/AMOT 28 CC GO:0070821 tertiary granule membrane 10/1118 73/19717 0.007932 0.05926 0.04827 ADAM8/LILRB2/SLC2A3/ITGAX/LILRA3/PTAFR/CD53/OLR1/ITGB2/NRAS 10 CC GO:0031941 filamentous actin 6/1118 32/19717 0.008347 0.06166 0.05022 PDLIM1/LDB3/PDLIM4/NCKAP1/ARPC3/PDLIM5 6 CC GO:0044448 cell cortex part 19/1118 184/19717 0.00849 0.06201 0.05051 CALD1/TMOD1/CORO1A/GSN/EPB41L2/CALB2/GPSM2/TPM4/SPTBN1/ASPH/HCLS1/DLC1/UNC13B/GMFG/HIP1/RIMS3/CTTN/CDH2/PVALB 19 CC GO:0098978 glutamatergic synapse 31/1118 349/19717 0.009119 0.06586 0.05365 PLCB1/CORO1A/STXBP1/CLSTN1/NDRG1/NTRK3/PTK2B/DAG1/ACTN1/SPTBN1/MYH10/PAK2/SPARCL1/DNM1/AKAP9/PIN1/NRGN/UNC13B/PURA/HIP1/MAPK10/USP46/APOE/PCDH17/ABR/NRP2/PFN2/PPP3CC/NPTX2/CHRM3/ADCY1 31 CC GO:0042383 sarcolemma 15/1118 136/19717 0.01028 0.07344 0.05982 SYNM/SSPN/ANK3/SGCA/BIN1/DAG1/FXYD1/DES/GOT2/CAV3/SNTA1/AQP1/SLC2A5/PDE9A/CDH2 15 CC GO:0071437 invadopodium 4/1118 16/19717 0.01081 0.07639 0.06222 SVIL/PAK1/PDPN/PLAUR 4 CC GO:0051233 spindle midzone 6/1118 34/19717 0.01125 0.07866 0.06407 MAPRE2/EML1/MAPRE3/CTTN/PLK1/CDC6 6 CC GO:0098562 cytoplasmic side of membrane 18/1118 178/19717 0.01252 0.08659 0.07053 LITAF/RGS1/LCK/PTK2B/PTPN7/CD2/CBX6/GNA11/RGS2/PTPRC/ESYT1/KCNAB1/PTPN22/EEF1A2/HIP1/TRAF3/GNG12/NPTX2 18 CC GO:0031092 platelet alpha granule membrane 4/1118 17/19717 0.01351 0.09247 0.07532 CYB5R1/APLP2/PECAM1/SELP 4 CC GO:0044304 main axon 9/1118 68/19717 0.01424 0.0964 0.07853 TNFRSF1B/ANK3/BIN1/DAG1/ADORA1/SPTBN1/KCNAB1/DNM1/THY1 9 CC GO:0030175 filopodium 12/1118 104/19717 0.01468 0.09724 0.07921 ARL4C/ITGAV/LCP1/DAG1/CBX6/PDPN/ACTA2/UNC5C/ACTA1/MYO1B/NPTX2/GAP43 12 CC GO:0098858 actin-based cell projection 20/1118 208/19717 0.0148 0.09724 0.07921 ARL4C/ANGPT1/ITGAV/AOC3/LCP1/CALB2/DAG1/AKR1B1/CBX6/CD44/PDPN/ADCY6/ACTA2/UNC5C/ACTA1/MYO1B/PDGFRA/PVALB/NPTX2/GAP43 20 CC GO:0008180 COP9 signalosome 6/1118 36/19717 0.01481 0.09724 0.07921 TMOD1/EPB41L2/HSPA5/BASP1/LAT/AMOT 6 CC GO:0000790 nuclear chromatin 32/1118 377/19717 0.01512 0.0983 0.08008 RUNX3/PLCB1/CBX7/KAT6B/IRF1/GATA3/PCGF2/ATRX/TCF7/TCF7L2/SMARCA1/SMAD3/BRD8/NACC2/AR/SMARCD3/HIF1A/CBX1/HDAC1/ZNHIT1/EHMT2/IKZF1/STAT1/CENPB/KAT5/SATB1/FOXC1/RING1/RXRA/TNP2/JUN/MBD2 32 CC GO:0030662 coated vesicle membrane 18/1118 182/19717 0.01545 0.09945 0.08101 CD3D/IL7R/TGFA/EGFR/NCALD/HBEGF/BTC/FZD2/TMED3/CD3G/NRGN/AP1B1/KDELR3/HIP1/KDELR1/APOE/TFRC/SLC18A2 18 CC GO:0005916 fascia adherens 3/1118 10/19717 0.01616 0.1029 0.08386 ACTN1/DES/CDH2 3 CC GO:0098802 plasma membrane receptor complex 26/1118 295/19717 0.01743 0.11 0.0896 CD247/TRBC1/CD3D/ITGB7/IL2RB/ITGAV/CD8A/PTK2B/ITGAX/CD40/SHANK2/CSF2RB/PTPN6/ITGAL/ITGA4/INSR/CD3G/ITGBL1/SKAP1/ITGA5/TLR2/BMPR1A/TRAF3/TFRC/ITGB2/IL2RA 26 CC GO:0044291 cell-cell contact zone 9/1118 71/19717 0.01852 0.1148 0.09349 ANK3/ACTN1/FXYD1/PAK1/DES/CAV3/PECAM1/PCDH9/CDH2 9 CC GO:0005604 basement membrane 11/1118 95/19717 0.01854 0.1148 0.09349 LOXL2/THBS2/DAG1/DST/EFNA5/EFEMP2/TIMP3/THBS4/LAMB2/LOXL1/COL4A1 11 CC GO:0043034 costamere 4/1118 19/19717 0.02012 0.1229 0.1001 SYNM/ANK3/SVIL/DAG1 4 CC GO:0017053 transcriptional repressor complex 10/1118 84/19717 0.02023 0.1229 0.1001 ZBTB16/RELB/CCND1/HDAC1/HDAC4/SPEN/LIN37/TFAP4/ELANE/JUN 10 CC GO:1902911 protein kinase complex 12/1118 109/19717 0.02062 0.1241 0.1011 CDK14/SIK1/CCND2/CKS1B/CCND1/INSR/CCNA2/CDK4/ERC1/CCNB1/IKBKG/CCNB2 12 CC GO:0030136 clathrin-coated vesicle 18/1118 188/19717 0.02082 0.1242 0.1011 CD3D/IL7R/TGFA/EGFR/NCALD/HBEGF/BTC/FZD2/RAB27A/CD3G/INPP5F/NRGN/AP1B1/HIP1/APOE/SNAP91/TFRC/SLC18A2 18 CC GO:0002116 semaphorin receptor complex 3/1118 11/19717 0.02129 0.1258 0.1025 PLXNC1/PLXNA2/NRP2 3 CC GO:0014704 intercalated disc 7/1118 50/19717 0.02191 0.1283 0.1045 ANK3/ACTN1/FXYD1/PAK1/DES/CAV3/CDH2 7 CC GO:0030135 coated vesicle 25/1118 289/19717 0.02383 0.1359 0.1107 CD3D/IL7R/TGFA/EGFR/NCALD/SERPINA1/HBEGF/BTC/FZD2/RAB27A/CTSC/TMED3/CD3G/INPP5F/NRGN/AP1B1/TEX261/KDELR3/F8/HIP1/KDELR1/APOE/SNAP91/TFRC/SLC18A2 25 CC GO:0005819 spindle 29/1118 347/19717 0.02403 0.1359 0.1107 MAPRE2/EML1/TTC28/KIF3B/DCTN3/GPSM2/HSPB1/CDC25B/MAPRE3/ANXA11/MYH10/PLK2/CAPG/CBX1/CCNB1/SNCG/TADA3/MTUS1/MAP4/CTTN/SPAG5/TPX2/PIN4/PLK1/JTB/SPICE1/TUBGCP4/IKBKG/CDC6 29 CC GO:0005721 pericentric heterochromatin 4/1118 20/19717 0.02405 0.1359 0.1107 ATRX/CBX1/IKZF1/CENPB 4 CC GO:0035145 exon-exon junction complex 4/1118 20/19717 0.02405 0.1359 0.1107 SAP18/UPF3A/CASC3/R3HCC1 4 CC GO:1902554 serine/threonine protein kinase complex 10/1118 88/19717 0.02706 0.1486 0.1211 CDK14/CCND2/CKS1B/CCND1/CCNA2/CDK4/ERC1/CCNB1/IKBKG/CCNB2 10 CC GO:0000109 nucleotide-excision repair complex 3/1118 12/19717 0.02721 0.1486 0.1211 ERCC1/CETN2/RAD23B 3 CC GO:0000812 Swr1 complex 3/1118 12/19717 0.02721 0.1486 0.1211 BRD8/ZNHIT1/KAT5 3 CC GO:0005833 hemoglobin complex 3/1118 12/19717 0.02721 0.1486 0.1211 HBB/CYB5R3/HBE1 3 CC GO:0014069 postsynaptic density 27/1118 324/19717 0.02956 0.1601 0.1304 MAGI2/SIPA1L1/CRYAB/CLSTN1/DCLK1/PTK2B/SHANK2/PSD3/ADORA1/SPTBN1/PAK2/DNM1/DLG5/AKAP9/HOMER3/NRGN/SEMA4F/PCBP2/RPLP0/MAP4/PDLIM5/ABR/CDH2/BNIP3/CHRM3/ADCY1/GAP43 27 CC GO:0031258 lamellipodium membrane 4/1118 22/19717 0.0332 0.175 0.1425 ITGAV/CD44/PDPN/NCKAP1 4 CC GO:0005913 cell-cell adherens junction 12/1118 117/19717 0.03357 0.175 0.1425 VEGFA/PDLIM1/NDRG1/DAG1/ACTN1/DES/LDB3/CDH5/DLG5/PDLIM4/PDLIM5/CDH2 12 CC GO:0097060 synaptic membrane 34/1118 432/19717 0.03367 0.175 0.1425 GABRB1/SIPA1L1/CRYAB/STXBP1/SSPN/STX11/ANK3/CLSTN1/NTRK3/CALB2/DAG1/SHANK2/PSD3/ADORA1/DNM1/DLG5/AKAP9/F2R/HOMER3/NRGN/SEMA4F/PDLIM4/UNC13B/ERC1/HIP1/GLRB/PCDH17/RIMS3/SNAP91/PDLIM5/CDH2/NRP2/CHRM3/ADCY1 34 CC GO:0032279 asymmetric synapse 27/1118 328/19717 0.03375 0.175 0.1425 MAGI2/SIPA1L1/CRYAB/CLSTN1/DCLK1/PTK2B/SHANK2/PSD3/ADORA1/SPTBN1/PAK2/DNM1/DLG5/AKAP9/HOMER3/NRGN/SEMA4F/PCBP2/RPLP0/MAP4/PDLIM5/ABR/CDH2/BNIP3/CHRM3/ADCY1/GAP43 27 CC GO:0042627 chylomicron 3/1118 13/19717 0.03392 0.175 0.1425 LPL/APOC1/APOE 3 CC GO:0099243 extrinsic component of synaptic membrane 3/1118 13/19717 0.03392 0.175 0.1425 AKAP9/HIP1/SNAP91 3 CC GO:0005775 vacuolar lumen 16/1118 172/19717 0.03545 0.1814 0.1478 SDC1/CTSD/CYB5R3/MAN2B2/CTSC/PYGB/CTSL/CTSF/GPC5/HEXA/GCA/LGMN/IMPDH1/PA2G4/ELANE/HYAL1 16 CC GO:0005901 caveola 9/1118 80/19717 0.0369 0.1859 0.1515 FXYD1/MAPK3/INSR/TFPI/CAV3/F2R/DLC1/EFNA5/BMPR1A 9 CC GO:0016528 sarcoplasm 9/1118 80/19717 0.0369 0.1859 0.1515 GSN/ANK3/HK2/PLN/NOL3/CASQ2/ASPH/ATP2A1/THBS4 9 CC GO:0043204 perikaryon 13/1118 134/19717 0.04092 0.2008 0.1635 CRYAB/SLC2A3/PAM/ASS1/GOT2/KCNAB1/OLFM1/CCR2/SEMA4F/MAPK10/KCNB2/PDE9A/G3BP1 13 CC GO:0009925 basal plasma membrane 5/1118 34/19717 0.04119 0.2008 0.1635 EGFR/ANK3/DST/SLC23A2/AQP1 5 CC GO:0030673 axolemma 3/1118 14/19717 0.04139 0.2008 0.1635 ADORA1/SPTBN1/THY1 3 CC GO:0034362 low-density lipoprotein particle 3/1118 14/19717 0.04139 0.2008 0.1635 PLA2G7/APOE/APOF 3 CC GO:0061702 inflammasome complex 3/1118 14/19717 0.04139 0.2008 0.1635 AIM2/CASP4/NLRP3 3 CC GO:0098984 neuron to neuron synapse 28/1118 350/19717 0.04229 0.2036 0.1659 MAGI2/SIPA1L1/CRYAB/CLSTN1/DCLK1/PTK2B/SHANK2/PSD3/ADORA1/SPTBN1/PAK2/DNM1/DLG5/AKAP9/HOMER3/NRGN/SEMA4F/UNC13B/PCBP2/RPLP0/MAP4/PDLIM5/ABR/CDH2/BNIP3/CHRM3/ADCY1/GAP43 28 CC GO:0099522 region of cytosol 4/1118 24/19717 0.04413 0.2109 0.1718 PRKCB/DAG1/PIN1/PPP3CC 4 CC GO:0072686 mitotic spindle 11/1118 109/19717 0.04497 0.2133 0.1738 EML1/TTC28/GPSM2/MAPRE3/CAPG/TADA3/MAP4/CTTN/SPAG5/TPX2/IKBKG 11 CC GO:0045211 postsynaptic membrane 26/1118 323/19717 0.04602 0.2168 0.1766 GABRB1/SIPA1L1/SSPN/ANK3/CLSTN1/NTRK3/DAG1/SHANK2/PSD3/ADORA1/DNM1/DLG5/AKAP9/F2R/HOMER3/NRGN/SEMA4F/PDLIM4/HIP1/GLRB/PCDH17/PDLIM5/CDH2/NRP2/CHRM3/ADCY1 26 CC GO:0016529 sarcoplasmic reticulum 8/1118 71/19717 0.04716 0.2174 0.1771 ANK3/HK2/PLN/NOL3/CASQ2/ASPH/ATP2A1/THBS4 8 CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 8/1118 71/19717 0.04716 0.2174 0.1771 TGFA/TAP1/SERPINA1/CTSC/TMED3/F8/KDELR1/TAPBP 8 CC GO:0098982 GABA-ergic synapse 8/1118 71/19717 0.04716 0.2174 0.1771 PLCB1/GABRB1/CLSTN1/DAG1/EFNA5/GLRB/PCDH17/GAP43 8 CC GO:0120111 neuron projection cytoplasm 9/1118 84/19717 0.0481 0.2187 0.1782 ADA/KIF3B/HSPB1/DST/KCNAB1/GABARAPL1/HIF1A/UCHL1/PURA 9 CC GO:0019897 extrinsic component of plasma membrane 15/1118 165/19717 0.04822 0.2187 0.1782 FCN1/SERPINE2/RGS1/LCK/PTK2B/GNA11/CDH5/ESYT1/KCNAB1/AKAP9/HIP1/SNAP91/CDH2/GNG12/ST14 15 CC GO:0031519 PcG protein complex 6/1118 47/19717 0.04846 0.2187 0.1782 EZH1/CBX7/PCGF2/CBX6/JARID2/RING1 6 CC GO:0033268 node of Ranvier 3/1118 15/19717 0.04962 0.2194 0.1787 ANK3/BIN1/DAG1 3 CC GO:0035102 PRC1 complex 3/1118 15/19717 0.04962 0.2194 0.1787 CBX7/PCGF2/RING1 3 CC GO:0090533 cation-transporting ATPase complex 3/1118 15/19717 0.04962 0.2194 0.1787 FXYD1/PLN/ATP4B 3 CC GO:0031965 nuclear membrane 24/1118 296/19717 0.05004 0.2198 0.179 PLCB1/IL15RA/GRK5/LTC4S/GCHFR/EGFR/PHLPP1/CPNE1/SMAD3/PAK1/CCND2/GCH1/SMAD1/CDK4/AQP1/LBR/LMNB1/DUSP2/CASC3/UTP18/NUP210/PTGDS/ALOX5/VAPA 24 CC GO:0016605 PML body 10/1118 99/19717 0.05397 0.2354 0.1918 ZBTB16/ATRX/TCF7L2/DAXX/ISG20/ELF4/MAPK7/USP7/SATB1/IKBKE 10 CC GO:0101003 ficolin-1-rich granule membrane 7/1118 61/19717 0.05634 0.2414 0.1966 ADAM8/LILRB2/SLC2A3/ITGAX/LILRA3/NCKAP1L/ITGB2 7 CC GO:0031253 cell projection membrane 27/1118 345/19717 0.05668 0.2414 0.1966 ITGAV/PHLPP1/LCP1/SHANK2/PSD3/PLEK/PAK1/ADORA1/SPTBN1/CD44/MXRA8/PDPN/PEX19/INSR/GABARAPL1/SH3YL1/KANK1/THY1/DLC1/ITGA5/PLAUR/NCKAP1/AQP1/DHRS3/PDE9A/PSD4/GAP43 27 CC GO:0000780 condensed nuclear chromosome, centromeric region 4/1118 26/19717 0.05684 0.2414 0.1966 ATRX/CCNB1/CENPB/PLK1 4 CC GO:0005766 primary lysosome 14/1118 155/19717 0.05742 0.2414 0.1966 CPNE1/CYB5R3/CTSC/PYGB/ANXA11/STXBP2/SYNGR1/HEXA/GCA/C3AR1/IMPDH1/PA2G4/VAPA/ELANE 14 CC GO:0042582 azurophil granule 14/1118 155/19717 0.05742 0.2414 0.1966 CPNE1/CYB5R3/CTSC/PYGB/ANXA11/STXBP2/SYNGR1/HEXA/GCA/C3AR1/IMPDH1/PA2G4/VAPA/ELANE 14 CC GO:0005770 late endosome 21/1118 256/19717 0.05756 0.2414 0.1966 CXCR4/MAGI2/LITAF/EGFR/PARM1/MAPK3/NEDD4L/RAB27A/NPC1/CTSL/CST7/CTSH/YIPF1/F2R/LAMP3/STOML1/MMD/HLA-DMA/RAB22A/HLA-DMB/LGMN 21 CC GO:0042613 MHC class II protein complex 3/1118 16/19717 0.05857 0.2441 0.1988 HLA-DOB/HLA-DMA/HLA-DMB 3 CC GO:0099572 postsynaptic specialization 27/1118 348/19717 0.06166 0.2553 0.208 MAGI2/SIPA1L1/CRYAB/CLSTN1/DCLK1/PTK2B/SHANK2/PSD3/ADORA1/SPTBN1/PAK2/DNM1/DLG5/AKAP9/HOMER3/NRGN/SEMA4F/PCBP2/RPLP0/MAP4/PDLIM5/ABR/CDH2/BNIP3/CHRM3/ADCY1/GAP43 27 CC GO:0061695 transferase complex, transferring phosphorus-containing groups 21/1118 259/19717 0.06349 0.261 0.2126 CDK14/REV3L/PFKM/SIK1/CCND2/CKS1B/CCND1/INSR/PAF1/ERCC1/CCNA2/CDK4/ERC1/CCNB1/POLR2E/TADA3/POLR2I/POLR1C/PRIM2/IKBKG/CCNB2 21 CC GO:0032809 neuronal cell body membrane 4/1118 27/19717 0.06385 0.261 0.2126 INSR/CX3CR1/THY1/KCNB2 4 CC GO:0030670 phagocytic vesicle membrane 8/1118 76/19717 0.06557 0.2664 0.217 RAC2/CORO1A/TAP1/RAPGEF1/TLR2/RAB22A/TAPBP/ATP6V0D1 8 CC GO:0016607 nuclear speck 30/1118 397/19717 0.06719 0.2687 0.2189 PLCB1/ZBTB16/GRK5/FTO/PNISR/NAMPT/DOCK1/AKAP17A/DDX39A/SAP18/AR/PIN1/HIF1A/BASP1/ZMIZ1/EHMT2/SRSF8/PRPF8/LPXN/CDC40/CASC3/SART1/NXF1/TENM1/CBY1/SREK1/RING1/TFIP11/POLDIP3/IL15 30 CC GO:0005771 multivesicular body 6/1118 51/19717 0.06738 0.2687 0.2189 EGFR/NEDD4L/RAB27A/CTSL/CST7/CTSH 6 CC GO:0044420 extracellular matrix component 6/1118 51/19717 0.06738 0.2687 0.2189 MFAP4/FBLN5/COL1A1/LAMB2/COL3A1/COL4A1 6 CC GO:0031143 pseudopodium 3/1118 17/19717 0.06823 0.2688 0.2189 ACTN1/MAPK3/LDB3 3 CC GO:0042599 lamellar body 3/1118 17/19717 0.06823 0.2688 0.2189 ABCA3/CTSH/LAMP3 3 CC GO:0044298 cell body membrane 4/1118 28/19717 0.07129 0.2792 0.2274 INSR/CX3CR1/THY1/KCNB2 4 CC GO:0010008 endosome membrane 35/1118 479/19717 0.07489 0.2915 0.2374 LITAF/ATP9A/EGFR/NDRG1/PARM1/STEAP1/CTSD/PRAF2/RAB27A/RNF144A/ARHGAP1/LY96/NPC1/CD14/MYD88/INSR/INPP5F/YIPF1/LAMP3/LDLRAD4/PDLIM4/ACAP1/STOML1/FZD7/DIO3/MMD/MYO1B/HLA-DOB/HLA-DMA/RAB22A/HLA-DMB/IRF7/TFRC/IKBKE/ATP6V0D1 35 CC GO:0031527 filopodium membrane 3/1118 18/19717 0.07855 0.3039 0.2476 ITGAV/PDPN/GAP43 3 CC GO:0031362 anchored component of external side of plasma membrane 3/1118 19/19717 0.08951 0.3406 0.2775 CD14/THY1/EFNA5 3 CC GO:0098644 complex of collagen trimers 3/1118 19/19717 0.08951 0.3406 0.2775 COL1A1/COL3A1/COL4A1 3 CC GO:0043202 lysosomal lumen 9/1118 95/19717 0.08961 0.3406 0.2775 SDC1/CTSD/MAN2B2/CTSL/CTSF/GPC5/HEXA/LGMN/HYAL1 9 CC GO:0016324 apical plasma membrane 24/1118 318/19717 0.09433 0.3565 0.2904 DDR2/P2RY6/SORBS2/EGFR/EMP2/STC1/SHANK2/PFKM/CLIC5/FXYD1/SLC23A2/RAB27A/CD44/SLC29A1/PDPN/SLC7A5/STXBP2/THY1/IGFBP2/AQP1/SLC2A5/AMOTL2/CDH2/ATP6V0D1 24 CC GO:0030663 COPI-coated vesicle membrane 3/1118 20/19717 0.1011 0.369 0.3006 TMED3/KDELR3/KDELR1 3 CC GO:0034361 very-low-density lipoprotein particle 3/1118 20/19717 0.1011 0.369 0.3006 LPL/APOC1/APOE 3 CC GO:0034385 triglyceride-rich plasma lipoprotein particle 3/1118 20/19717 0.1011 0.369 0.3006 LPL/APOC1/APOE 3 CC GO:0035267 NuA4 histone acetyltransferase complex 3/1118 20/19717 0.1011 0.369 0.3006 BRD8/MSL3/KAT5 3 CC GO:0043189 H4/H2A histone acetyltransferase complex 3/1118 20/19717 0.1011 0.369 0.3006 BRD8/MSL3/KAT5 3 CC GO:0071682 endocytic vesicle lumen 3/1118 20/19717 0.1011 0.369 0.3006 HBB/APOE/GNLY 3 CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 11/1118 126/19717 0.1021 0.3707 0.302 TGFA/TAP1/SERPINA1/CTSC/HSPA5/STK17B/TMED3/F8/KDELR1/TAPBP/PTPN2 11 CC GO:0032839 dendrite cytoplasm 4/1118 32/19717 0.1052 0.3797 0.3093 ADA/KCNAB1/GABARAPL1/PURA 4 CC GO:0097470 ribbon synapse 2/1118 10/19717 0.1068 0.3817 0.3109 DNM1/UNC13B 2 CC GO:0048786 presynaptic active zone 7/1118 71/19717 0.1069 0.3817 0.3109 STXBP1/STX11/PNISR/ADORA1/UNC13B/RIMS3/CDH2 7 CC GO:0042827 platelet dense granule 3/1118 21/19717 0.1132 0.3978 0.324 RARRES2/TIMP3/SELP 3 CC GO:0098533 ATPase dependent transmembrane transport complex 3/1118 21/19717 0.1132 0.3978 0.324 FXYD1/PLN/ATP4B 3 CC GO:0044438 microbody part 9/1118 100/19717 0.1138 0.3978 0.324 ECH1/GRHPR/CRAT/PEX19/SLC27A2/ACOX2/CRYM/ALDH3A2/IMPDH2 9 CC GO:0044439 peroxisomal part 9/1118 100/19717 0.1138 0.3978 0.324 ECH1/GRHPR/CRAT/PEX19/SLC27A2/ACOX2/CRYM/ALDH3A2/IMPDH2 9 CC GO:0030496 midbody 14/1118 173/19717 0.1146 0.3985 0.3246 SVIL/TTC28/KIF3B/DCTN3/MAPRE3/ANXA11/RALA/MYH10/HSPA5/CAPG/PIN1/SPAG5/PLK1/JTB 14 CC GO:0046658 anchored component of plasma membrane 6/1118 59/19717 0.1163 0.4022 0.3276 CD2/CD14/THY1/EFNA5/GAS1/GPC5 6 CC GO:1904949 ATPase complex 9/1118 101/19717 0.1191 0.4095 0.3336 SMARCA1/FXYD1/PLN/BRD8/ATP4B/SMARCD3/HDAC1/ZNHIT1/KAT5 9 CC GO:0031904 endosome lumen 4/1118 34/19717 0.1244 0.4195 0.3417 CTSL/CTSH/PDLIM4/LGMN 4 CC GO:0005583 fibrillar collagen trimer 2/1118 11/19717 0.1259 0.4195 0.3417 COL1A1/COL3A1 2 CC GO:0031094 platelet dense tubular network 2/1118 11/19717 0.1259 0.4195 0.3417 F2R/ATP2A1 2 CC GO:0031838 haptoglobin-hemoglobin complex 2/1118 11/19717 0.1259 0.4195 0.3417 HBB/HBE1 2 CC GO:0035631 CD40 receptor complex 2/1118 11/19717 0.1259 0.4195 0.3417 CD40/TRAF3 2 CC GO:0098643 banded collagen fibril 2/1118 11/19717 0.1259 0.4195 0.3417 COL1A1/COL3A1 2 CC GO:0070382 exocytic vesicle 16/1118 207/19717 0.1296 0.4297 0.35 SV2B/STX11/SYNGR2/BIN1/RAB27A/ICA1/DNM1/SYT17/SYNGR1/UNC13B/NTF3/NGF/SNAP91/WFS1/ATP6V0D1/SLC18A2 16 CC GO:0005667 transcription factor complex 26/1118 365/19717 0.1372 0.4527 0.3688 RUNX3/HOXA10/WWTR1/HMGA1/PDLIM1/SIX1/THRA/TCF7/TCF7L2/SMAD3/PITX1/SMAD1/HCLS1/ERCC1/HIF1A/CDK4/HDAC1/TADA3/KAT5/CARM1/HOXA11/SMAD6/RXRA/TCF15/ATF5/JUN 26 CC GO:0005777 peroxisome 11/1118 134/19717 0.1393 0.454 0.3698 ECH1/GRHPR/CRAT/PEX19/SLC27A2/ACOX2/PMVK/AKAP11/CRYM/ALDH3A2/IMPDH2 11 CC GO:0042579 microbody 11/1118 134/19717 0.1393 0.454 0.3698 ECH1/GRHPR/CRAT/PEX19/SLC27A2/ACOX2/PMVK/AKAP11/CRYM/ALDH3A2/IMPDH2 11 CC GO:0005769 early endosome 25/1118 350/19717 0.1397 0.454 0.3698 CXCR4/LITAF/ATP9A/CORO1A/EPHA3/EGFR/AOC3/PARM1/RFTN1/MAPK3/RAB29/TM9SF4/INPP5F/RAPGEF1/F2R/LAMP3/LDLRAD4/PDLIM4/PHB/MYO1B/APOE/RAB22A/PTP4A3/TFRC/ATP6V0D1 25 CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 8/1118 91/19717 0.1441 0.4606 0.3752 RGS1/LCK/PTK2B/GNA11/ESYT1/KCNAB1/HIP1/GNG12 8 CC GO:0005890 sodium:potassium-exchanging ATPase complex 2/1118 12/19717 0.1456 0.4606 0.3752 FXYD1/ATP4B 2 CC GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 2/1118 12/19717 0.1456 0.4606 0.3752 CUL4A/GLMN 2 CC GO:0071006 U2-type catalytic step 1 spliceosome 2/1118 12/19717 0.1456 0.4606 0.3752 PRPF8/CASC3 2 CC GO:0071012 catalytic step 1 spliceosome 2/1118 12/19717 0.1456 0.4606 0.3752 PRPF8/CASC3 2 CC GO:0032155 cell division site part 6/1118 63/19717 0.146 0.4606 0.3752 SVIL/DCTN3/RALA/MYH10/PSTPIP1/TUBGCP4 6 CC GO:0031233 intrinsic component of external side of plasma membrane 3/1118 24/19717 0.1524 0.4764 0.388 CD14/THY1/EFNA5 3 CC GO:0044305 calyx of Held 3/1118 24/19717 0.1524 0.4764 0.388 PRKCB/ADORA1/UNC13B 3 CC GO:0005923 bicellular tight junction 10/1118 123/19717 0.1602 0.4938 0.4022 MAGI2/ANK3/CLDN7/CCND1/MXRA8/CDH5/CDK4/AMOTL2/VAPA/AMOT 10 CC GO:0005782 peroxisomal matrix 5/1118 51/19717 0.1613 0.4938 0.4022 ECH1/GRHPR/CRAT/ACOX2/CRYM 5 CC GO:0031907 microbody lumen 5/1118 51/19717 0.1613 0.4938 0.4022 ECH1/GRHPR/CRAT/ACOX2/CRYM 5 CC GO:0045178 basal part of cell 5/1118 51/19717 0.1613 0.4938 0.4022 EGFR/ANK3/DST/SLC23A2/AQP1 5 CC GO:0001931 uropod 2/1118 13/19717 0.1659 0.4938 0.4022 SELPLG/PSTPIP1 2 CC GO:0005736 RNA polymerase I complex 2/1118 13/19717 0.1659 0.4938 0.4022 POLR2E/POLR1C 2 CC GO:0005952 cAMP-dependent protein kinase complex 2/1118 13/19717 0.1659 0.4938 0.4022 PRKG1/PRKY 2 CC GO:0031254 cell trailing edge 2/1118 13/19717 0.1659 0.4938 0.4022 SELPLG/PSTPIP1 2 CC GO:1990023 mitotic spindle midzone 2/1118 13/19717 0.1659 0.4938 0.4022 EML1/CTTN 2 CC GO:0042611 MHC protein complex 3/1118 25/19717 0.1664 0.4938 0.4022 HLA-DOB/HLA-DMA/HLA-DMB 3 CC GO:0097346 INO80-type complex 3/1118 25/19717 0.1664 0.4938 0.4022 BRD8/ZNHIT1/KAT5 3 CC GO:0030315 T-tubule 5/1118 52/19717 0.1707 0.5044 0.4109 ANK3/BIN1/FXYD1/GOT2/CAV3 5 CC GO:0030133 transport vesicle 27/1118 392/19717 0.1718 0.5053 0.4116 CPA3/SV2B/TGFA/SSPN/STX11/NCALD/SYNGR2/BIN1/PAM/RAB27A/ICA1/TMED3/DNM1/SYT17/YIPF1/SYNGR1/NRGN/UNC13B/NTF3/KDELR3/KDELR1/NGF/SNAP91/FGFR3/WFS1/ATP6V0D1/SLC18A2 27 CC GO:0005811 lipid droplet 7/1118 81/19717 0.1751 0.5127 0.4176 FABP4/PLIN1/SYNGR2/CYB5R3/METTL7A/G0S2/DHRS3 7 CC GO:0033017 sarcoplasmic reticulum membrane 4/1118 39/19717 0.178 0.519 0.4227 PLN/CASQ2/ASPH/ATP2A1 4 CC GO:0000346 transcription export complex 2/1118 14/19717 0.1866 0.5293 0.4312 DDX39A/NXF1 2 CC GO:0000940 condensed chromosome outer kinetochore 2/1118 14/19717 0.1866 0.5293 0.4312 CCNB1/PLK1 2 CC GO:0005767 secondary lysosome 2/1118 14/19717 0.1866 0.5293 0.4312 ADAM8/NCF2 2 CC GO:0031089 platelet dense granule lumen 2/1118 14/19717 0.1866 0.5293 0.4312 RARRES2/TIMP3 2 CC GO:0043083 synaptic cleft 2/1118 14/19717 0.1866 0.5293 0.4312 APOE/LAMB2 2 CC GO:0099523 presynaptic cytosol 2/1118 14/19717 0.1866 0.5293 0.4312 PRKCB/PPP3CC 2 CC GO:0032153 cell division site 6/1118 68/19717 0.1873 0.5293 0.4312 SVIL/DCTN3/RALA/MYH10/PSTPIP1/TUBGCP4 6 CC GO:0070160 tight junction 10/1118 128/19717 0.1903 0.534 0.435 MAGI2/ANK3/CLDN7/CCND1/MXRA8/CDH5/CDK4/AMOTL2/VAPA/AMOT 10 CC GO:0005902 microvillus 7/1118 83/19717 0.1906 0.534 0.435 ANGPT1/ITGAV/AOC3/AKR1B1/CD44/PDPN/PDGFRA 7 CC GO:0001891 phagocytic cup 3/1118 27/19717 0.1953 0.5389 0.439 ARHGAP12/CORO1A/LCP1 3 CC GO:0030137 COPI-coated vesicle 3/1118 27/19717 0.1953 0.5389 0.439 TMED3/KDELR3/KDELR1 3 CC GO:0097431 mitotic spindle pole 3/1118 27/19717 0.1953 0.5389 0.439 EML1/GPSM2/SPAG5 3 CC GO:0005905 clathrin-coated pit 6/1118 69/19717 0.1961 0.5389 0.439 INPP5F/HIP1/FNBP1/CTTN/SNAP91/TFRC 6 CC GO:0008021 synaptic vesicle 14/1118 191/19717 0.1965 0.5389 0.439 SV2B/STX11/SYNGR2/BIN1/ICA1/DNM1/SYNGR1/UNC13B/NTF3/NGF/SNAP91/WFS1/ATP6V0D1/SLC18A2 14 CC GO:0032154 cleavage furrow 5/1118 55/19717 0.2002 0.5446 0.4436 SVIL/DCTN3/RALA/MYH10/PSTPIP1 5 CC GO:0045177 apical part of cell 26/1118 384/19717 0.2002 0.5446 0.4436 DDR2/P2RY6/SORBS2/EGFR/EMP2/STC1/SHANK2/PFKM/CLIC5/FXYD1/SLC23A2/RAB27A/CD44/SLC29A1/PDPN/SLC7A5/STXBP2/THY1/IGFBP2/MYO1B/AQP1/SLC2A5/AMOTL2/LGMN/CDH2/ATP6V0D1 26 CC GO:0042734 presynaptic membrane 12/1118 161/19717 0.2034 0.5508 0.4486 STXBP1/STX11/ADORA1/DNM1/UNC13B/ERC1/HIP1/PCDH17/RIMS3/SNAP91/CDH2/CHRM3 12 CC GO:0000778 condensed nuclear chromosome kinetochore 2/1118 15/19717 0.2077 0.5533 0.4507 CCNB1/PLK1 2 CC GO:0005665 RNA polymerase II, core complex 2/1118 15/19717 0.2077 0.5533 0.4507 POLR2E/POLR2I 2 CC GO:0012510 trans-Golgi network transport vesicle membrane 2/1118 15/19717 0.2077 0.5533 0.4507 NCALD/NRGN 2 CC GO:0045120 pronucleus 2/1118 15/19717 0.2077 0.5533 0.4507 CCNA2/CBX1 2 CC GO:0072562 blood microparticle 11/1118 147/19717 0.2127 0.5615 0.4574 HBB/GSN/CFB/ACTA1/CP/IGKC/APOE/APCS/TFRC/IGLC1/HBE1 11 CC GO:0099738 cell cortex region 4/1118 42/19717 0.2134 0.5615 0.4574 EPB41L2/GPSM2/UNC13B/RIMS3 4 CC GO:1990391 DNA repair complex 4/1118 42/19717 0.2134 0.5615 0.4574 TP53BP1/ERCC1/CETN2/RAD23B 4 CC GO:0090575 RNA polymerase II transcription factor complex 12/1118 163/19717 0.215 0.5636 0.4591 RUNX3/HMGA1/THRA/TCF7L2/SMAD3/ERCC1/HIF1A/TADA3/CARM1/RXRA/TCF15/JUN 12 CC GO:0032589 neuron projection membrane 5/1118 57/19717 0.2208 0.5722 0.4661 ADORA1/SPTBN1/INSR/GABARAPL1/THY1 5 CC GO:1904115 axon cytoplasm 5/1118 57/19717 0.2208 0.5722 0.4661 KIF3B/HSPB1/DST/HIF1A/UCHL1 5 CC GO:0000922 spindle pole 12/1118 164/19717 0.221 0.5722 0.4661 EML1/TTC28/GPSM2/CDC25B/PLK2/CCNB1/SPAG5/TPX2/PLK1/TUBGCP4/IKBKG/CDC6 12 CC GO:1902562 H4 histone acetyltransferase complex 4/1118 43/19717 0.2256 0.5792 0.4718 BRD8/TADA3/MSL3/KAT5 4 CC GO:0030479 actin cortical patch 2/1118 16/19717 0.229 0.5792 0.4718 GMFG/HIP1 2 CC GO:0035098 ESC/E(Z) complex 2/1118 16/19717 0.229 0.5792 0.4718 EZH1/JARID2 2 CC GO:0061645 endocytic patch 2/1118 16/19717 0.229 0.5792 0.4718 GMFG/HIP1 2 CC GO:0098831 presynaptic active zone cytoplasmic component 2/1118 16/19717 0.229 0.5792 0.4718 UNC13B/RIMS3 2 CC GO:0098793 presynapse 32/1118 491/19717 0.2307 0.5792 0.4718 SV2B/STXBP1/STX11/PNISR/SYNGR2/PRKCB/BIN1/CALB2/DNMBP/ADORA1/SLC29A1/ICA1/DNM1/SYT17/SYNGR1/GOT1/UNC13B/NTF3/ERC1/HIP1/NGF/PCDH17/RIMS3/SNAP91/KIAA1109/CDH2/PFN2/WFS1/PPP3CC/ATP6V0D1/CHRM3/SLC18A2 32 CC GO:0000118 histone deacetylase complex 5/1118 58/19717 0.2313 0.5792 0.4718 SAP18/HDAC1/RERE/HDAC4/MBD2 5 CC GO:0030176 integral component of endoplasmic reticulum membrane 11/1118 150/19717 0.2316 0.5792 0.4718 TAP1/XBP1/TECR/HSPA5/ESYT1/SLC27A2/GPAA1/ATF6/TEX261/TAPBP/WFS1 11 CC GO:0018995 host 6/1118 73/19717 0.2326 0.5792 0.4718 AXL/RAB29/GBP2/AQP1/PF4/NUP210 6 CC GO:0043657 host cell 6/1118 73/19717 0.2326 0.5792 0.4718 AXL/RAB29/GBP2/AQP1/PF4/NUP210 6 CC GO:0030669 clathrin-coated endocytic vesicle membrane 4/1118 44/19717 0.2379 0.5878 0.4788 HBEGF/FZD2/HIP1/APOE 4 CC GO:0044445 cytosolic part 17/1118 247/19717 0.2383 0.5878 0.4788 HBB/PRKCB/AIM2/DAG1/PFKM/CYB5R3/RPS5/CASP4/PIN1/RPL18/ERC1/RPLP0/NLRP3/RPL13/IKBKG/PPP3CC/HBE1 17 CC GO:0030666 endocytic vesicle membrane 12/1118 167/19717 0.2392 0.5878 0.4788 RAC2/CORO1A/TAP1/HBEGF/FZD2/RAPGEF1/HIP1/TLR2/APOE/RAB22A/TAPBP/ATP6V0D1 12 CC GO:0048787 presynaptic active zone membrane 3/1118 30/19717 0.2406 0.5878 0.4788 STXBP1/STX11/CDH2 3 CC GO:0071007 U2-type catalytic step 2 spliceosome 3/1118 30/19717 0.2406 0.5878 0.4788 PRPF8/CDC40/SNRPD2 3 CC GO:0005684 U2-type spliceosomal complex 7/1118 90/19717 0.2487 0.5991 0.488 HTATSF1/PRPF8/CDC40/CASC3/SART1/TFIP11/SNRPD2 7 CC GO:0005666 RNA polymerase III complex 2/1118 17/19717 0.2505 0.5991 0.488 POLR2E/POLR1C 2 CC GO:0030014 CCR4-NOT complex 2/1118 17/19717 0.2505 0.5991 0.488 CNOT1/CNOT4 2 CC GO:0042622 photoreceptor outer segment membrane 2/1118 17/19717 0.2505 0.5991 0.488 PHLPP1/DHRS3 2 CC GO:0099524 postsynaptic cytosol 2/1118 17/19717 0.2505 0.5991 0.488 DAG1/PIN1 2 CC GO:0044450 microtubule organizing center part 13/1118 185/19717 0.2516 0.5991 0.488 DZIP1/LCK/PLK2/CAPG/NEK1/PARP3/CETN2/SPAG5/PLK1/CBY1/SPICE1/TUBGCP4/STIL 13 CC GO:0043197 dendritic spine 12/1118 169/19717 0.2516 0.5991 0.488 SIPA1L1/CRYAB/CLSTN1/PTK2B/FCGR2B/SHANK2/ADORA1/MYH10/DNM1/NRGN/PDLIM4/CTTN 12 CC GO:0044306 neuron projection terminus 10/1118 138/19717 0.2571 0.6075 0.4948 PRKCB/ADORA1/GCH1/UCHL1/GOT1/UNC13B/SCRG1/ATP6V0D1/CHRM3/SLC18A2 10 CC GO:0035578 azurophil granule lumen 7/1118 91/19717 0.2574 0.6075 0.4948 CYB5R3/CTSC/PYGB/GCA/IMPDH1/PA2G4/ELANE 7 CC GO:0031225 anchored component of membrane 12/1118 170/19717 0.2579 0.6075 0.4948 GFRA2/CD48/CD2/ALPL/CD14/TFPI/THY1/EFNA5/GAS1/PLAUR/GPC5/CD52 12 CC GO:0070603 SWI/SNF superfamily-type complex 6/1118 76/19717 0.2612 0.6129 0.4993 SMARCA1/BRD8/SMARCD3/HDAC1/ZNHIT1/KAT5 6 MF GO:0008307 structural constituent of muscle 18/1104 46/17697 9.479e-11 9.062e-08 7.683e-08 SYNM/TPM2/SORBS2/MYL6B/DAG1/TPM4/MYL2/MYH11/CSRP1/ASPH/MYL9/MYOM2/MYL3/MYL1/TTN/MYBPC2/NEB/MYOM1 18 MF GO:0004896 cytokine receptor activity 25/1104 96/17697 6.011e-10 2.873e-07 2.436e-07 IL4R/CXCR4/IL15RA/IL2RG/IFNAR2/IL7R/IL2RB/IL11RA/GFRA2/CCR7/CSF2RB/IL27RA/CCR5/CD44/CX3CR1/CCR2/CXCR6/CCR6/IL17RA/IL2RA/IL3RA/LIFR/IL9R/CSF2RA/CRLF1 25 MF GO:0019838 growth factor binding 30/1104 137/17697 1.157e-09 3.688e-07 3.127e-07 TGFBR3/IL2RG/CXCL13/IL2RB/IL11RA/ITGAV/EGFR/PXDN/IL1RN/NTRK3/IGFBP7/KAZALD1/INSR/COL1A1/FGFR1/S100A13/IGFBP6/LTBP4/IGFBP2/IGFBP5/HTRA1/BMPR1A/NRP2/FGFR3/IL2RA/PDGFRA/LIFR/COL3A1/COL4A1/FLT1 30 MF GO:0019955 cytokine binding 27/1104 128/17697 1.818e-08 4.344e-06 3.683e-06 TNFRSF1B/TGFBR3/CXCR4/IL2RG/IL2RB/IL11RA/ITGAV/PXDN/IL1RN/CCR7/IL27RA/CCR5/PDPN/ITGA4/CX3CR1/CCR2/LTBP4/CXCR6/CCR6/GBP1/NRP2/IL2RA/IL3RA/LIFR/CSF2RA/ELANE/CRLF1 27 MF GO:0003779 actin binding 58/1104 431/17697 2.442e-08 4.623e-06 3.92e-06 CXCR4/PARVA/CALD1/TMOD1/CORO1A/TPM2/GSN/PDLIM1/EGFR/NCALD/SVIL/EPB41L1/FLNB/LCP1/EPB41L2/BIN1/DAG1/ACTN1/EEF2/TPM4/DST/TLN2/MYL2/LDB3/CCR5/SPTBN1/MYH11/MYH10/ABLIM1/TNNC2/MYH2/HCLS1/MYOM2/MYH7/CAPG/TNNC1/MYL3/TAGLN/PDLIM4/TNNI1/SNTA1/GMFG/TPM3/MYO1B/TTN/MYBPC2/HIP1/GBP1/NEB/CTTN/ARPC3/PDLIM5/PSTPIP1/COBL/PFN2/MYOM1/ALDOA/MARCKSL1 58 MF GO:0005539 glycosaminoglycan binding 38/1104 229/17697 2.902e-08 4.623e-06 3.92e-06 TGFBR3/SERPINE2/LPL/CXCL13/SEMA5A/TNFAIP6/VEGFA/SPOCK2/HBEGF/THBS2/POSTN/SULF1/NELL1/APLP2/CD44/PTPRC/LIPC/ADAMTS3/FGFR1/CXCL6/LTBP4/BMP4/SELL/PF4/TLR2/APOE/CXCL10/SUSD5/THBS4/NLRP3/PTPRF/SFRP1/NRP2/TENM1/SELP/ELANE/CCL7/PCOLCE 38 MF GO:0005126 cytokine receptor binding 43/1104 286/17697 7.074e-08 9.324e-06 7.905e-06 TGFBR3/CCL5/CXCL13/CCL13/TGFB2/VEGFA/PXDN/IL1RN/GATA3/IL1B/CCL18/SMAD3/CXCL8/NOL3/TNFSF10/CDH5/TRAF1/CXCL1/MYD88/TRAP1/CCR2/CXCL6/BMP4/ITGA5/EFNA5/NTF3/PF4/CXCL3/STAT1/NGF/CXCL10/GDF10/CXCL12/TRAF3/TNFSF14/CCL2/LIFR/SMAD6/SIVA1/INHBB/CCL7/CRLF1/IL15 43 MF GO:0001618 virus receptor activity 19/1104 74/17697 8.778e-08 9.324e-06 7.905e-06 CXCR4/ITGB7/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CCR5/NPC1/HAVCR1/SLC20A2/ITGA5/TNFRSF4/CD86/TFRC/TYRO3/SIVA1 19 MF GO:0104005 hijacked molecular function 19/1104 74/17697 8.778e-08 9.324e-06 7.905e-06 CXCR4/ITGB7/ITGAV/EGFR/AXL/ICAM1/DAG1/SLAMF1/SELPLG/CCR5/NPC1/HAVCR1/SLC20A2/ITGA5/TNFRSF4/CD86/TFRC/TYRO3/SIVA1 19 MF GO:0051015 actin filament binding 33/1104 198/17697 2.103e-07 2.011e-05 1.705e-05 TMOD1/CORO1A/TPM2/GSN/EGFR/SVIL/LCP1/BIN1/ACTN1/EEF2/TPM4/TLN2/MYH11/MYH10/ABLIM1/TNNC2/MYH2/HCLS1/MYOM2/MYH7/CAPG/TNNC1/TAGLN/TPM3/MYO1B/TTN/MYBPC2/HIP1/NEB/CTTN/ARPC3/PSTPIP1/MYOM1 33 MF GO:0008201 heparin binding 29/1104 169/17697 6.068e-07 5.274e-05 4.471e-05 TGFBR3/SERPINE2/LPL/CXCL13/VEGFA/HBEGF/THBS2/POSTN/NELL1/APLP2/PTPRC/LIPC/ADAMTS3/FGFR1/CXCL6/BMP4/SELL/PF4/APOE/CXCL10/THBS4/PTPRF/SFRP1/NRP2/TENM1/SELP/ELANE/CCL7/PCOLCE 29 MF GO:0050839 cell adhesion molecule binding 60/1104 499/17697 7.58e-07 6.038e-05 5.119e-05 SPP1/PARVA/CALD1/ADAM8/ITGB7/ITGAV/PDLIM1/EGFR/ANK3/LILRB2/FNBP1L/NDRG1/ICAM1/CD226/EMP2/FLNB/LCP1/PPL/IL1B/ACTN1/EEF2/POSTN/DST/PTPN6/ITGAL/HDLBP/FBLN5/ARHGAP1/SPTBN1/HSPA5/CDH5/ITGA4/PAK2/TIMP2/ITGBL1/CAPG/LTBP4/THY1/ITGA5/ERC1/MYO1B/CAMLG/SND1/STAT1/CTTN/KTN1/PDLIM5/CXCL12/THBS4/PTPRF/LAMB2/CDH2/ITGB2/PTPN2/TENM1/EEF1D/COL3A1/VAPA/ALDOA/CCNB2 60 MF GO:0008009 chemokine activity 13/1104 49/17697 6.438e-06 0.0004532 0.0003842 CCL5/CXCL13/CCL13/CCL18/CXCL8/CXCL1/CXCL6/PF4/CXCL3/CXCL10/CXCL12/CCL2/CCL7 13 MF GO:0005178 integrin binding 23/1104 132/17697 6.637e-06 0.0004532 0.0003842 SPP1/ITGB7/ITGAV/EGFR/ICAM1/CD226/EMP2/LCP1/IL1B/ACTN1/DST/FBLN5/TIMP2/ITGBL1/LTBP4/THY1/ITGA5/CXCL12/THBS4/LAMB2/ITGB2/PTPN2/COL3A1 23 MF GO:0044389 ubiquitin-like protein ligase binding 40/1104 308/17697 8.624e-06 0.0005496 0.000466 FOXO1/TNFRSF1B/CXCR4/EGR2/EGFR/PTK2B/CD40/SMAD3/DAXX/BAG1/NFKBIA/RALA/HSPA5/TRIB2/TRAF1/MFHAS1/TRIP4/GABARAPL1/PTPN22/HIF1A/PINK1/ATF6/UCHL1/CCNB1/PCBP2/CAMLG/UBE2J1/USP7/STAT1/TRAF3/CASC3/WFS1/CUL4A/IKBKG/SMAD6/PA2G4/IKBKE/UQCRC1/JUN/GLMN 40 MF GO:0042379 chemokine receptor binding 15/1104 66/17697 1.014e-05 0.0006057 0.0005135 CCL5/CXCL13/CCL13/CCL18/CXCL8/CXCL1/CCR2/CXCL6/PF4/CXCL3/STAT1/CXCL10/CXCL12/CCL2/CCL7 15 MF GO:0019956 chemokine binding 10/1104 32/17697 1.562e-05 0.0008782 0.0007445 CXCR4/ITGAV/CCR7/CCR5/PDPN/ITGA4/CX3CR1/CCR2/CXCR6/CCR6 10 MF GO:0019199 transmembrane receptor protein kinase activity 16/1104 79/17697 2.444e-05 0.001298 0.0011 TGFBR3/DDR2/EPHA3/EGFR/AXL/NTRK3/INSR/FGFR1/LTBP4/EFEMP1/BMPR1A/NRP2/FGFR3/PDGFRA/TYRO3/FLT1 16 MF GO:0031625 ubiquitin protein ligase binding 37/1104 290/17697 2.749e-05 0.001314 0.001114 FOXO1/TNFRSF1B/CXCR4/EGR2/EGFR/PTK2B/CD40/SMAD3/DAXX/BAG1/NFKBIA/RALA/HSPA5/TRIB2/TRAF1/MFHAS1/GABARAPL1/PTPN22/HIF1A/PINK1/ATF6/UCHL1/PCBP2/CAMLG/UBE2J1/USP7/TRAF3/CASC3/WFS1/CUL4A/IKBKG/SMAD6/PA2G4/IKBKE/UQCRC1/JUN/GLMN 37 MF GO:0004713 protein tyrosine kinase activity 22/1104 134/17697 2.749e-05 0.001314 0.001114 DDR2/EPHA3/EGFR/AXL/ITK/LCK/NTRK3/PTK2B/CLK1/INSR/FGFR1/NEK1/DYRK2/EFEMP1/TTN/SLA/CSK/NRP2/FGFR3/PDGFRA/TYRO3/FLT1 22 MF GO:1901681 sulfur compound binding 33/1104 250/17697 3.713e-05 0.00169 0.001433 ALDH6A1/TGFBR3/SERPINE2/LPL/CXCL13/SEMA5A/VEGFA/ENPP1/HBEGF/THBS2/POSTN/NELL1/APLP2/PTPRC/LIPC/ADAMTS3/PC/FGFR1/CXCL6/BMP4/SELL/PF4/APOE/CXCL10/THBS4/PTPRF/SFRP1/NRP2/TENM1/SELP/ELANE/CCL7/PCOLCE 33 MF GO:0051371 muscle alpha-actinin binding 8/1104 23/17697 4.715e-05 0.002049 0.001737 PDLIM1/LDB3/MYOM2/PDLIM4/TTN/MYBPC2/PDLIM5/MYOM1 8 MF GO:0042805 actinin binding 11/1104 46/17697 9.343e-05 0.003807 0.003228 PDLIM1/DAG1/LDB3/NFKB1/CSRP1/MYOM2/PDLIM4/TTN/MYBPC2/PDLIM5/MYOM1 11 MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/1104 62/17697 9.558e-05 0.003807 0.003228 DDR2/EPHA3/EGFR/AXL/NTRK3/INSR/FGFR1/EFEMP1/NRP2/FGFR3/PDGFRA/TYRO3/FLT1 13 MF GO:0005125 cytokine activity 29/1104 220/17697 0.0001101 0.004211 0.00357 SPP1/CCL5/CXCL13/CCL13/TGFB2/VEGFA/IL32/ADIPOQ/IL1RN/IL1B/CCL18/NAMPT/CXCL8/TNFSF10/SECTM1/CXCL1/CXCL6/BMP4/PF4/CXCL3/CXCL10/GDF10/CXCL12/TNFSF14/CCL2/INHBB/CCL7/CRLF1/IL15 29 MF GO:0005520 insulin-like growth factor binding 8/1104 28/17697 0.000226 0.00831 0.007045 ITGAV/IGFBP7/KAZALD1/INSR/IGFBP6/IGFBP2/IGFBP5/HTRA1 8 MF GO:0008191 metalloendopeptidase inhibitor activity 6/1104 16/17697 0.0002706 0.00958 0.008122 SPOCK2/TIMP4/RARRES1/TIMP2/TIMP3/NGF 6 MF GO:0004601 peroxidase activity 11/1104 52/17697 0.0002999 0.009986 0.008466 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/GPX1/LPO/GSTT1/PRDX2/HBE1 11 MF GO:0015026 coreceptor activity 10/1104 44/17697 0.0003029 0.009986 0.008466 TGFBR3/CXCR4/ITGAV/CD8A/CCR5/LY96/ITGA4/CXCR6/LRP5/CD86 10 MF GO:0045236 CXCR chemokine receptor binding 5/1104 11/17697 0.000315 0.01004 0.008511 CXCL13/CXCL8/PF4/CXCL10/CXCL12 5 MF GO:0051393 alpha-actinin binding 9/1104 37/17697 0.0003514 0.01084 0.009187 PDLIM1/DAG1/LDB3/MYOM2/PDLIM4/TTN/MYBPC2/PDLIM5/MYOM1 9 MF GO:0016493 C-C chemokine receptor activity 7/1104 23/17697 0.0003649 0.0109 0.009243 CXCR4/CCR7/CCR5/CX3CR1/CCR2/CXCR6/CCR6 7 MF GO:0032813 tumor necrosis factor receptor superfamily binding 10/1104 46/17697 0.0004442 0.01287 0.01091 NOL3/TNFSF10/TRAF1/MYD88/TRAP1/STAT1/NGF/TRAF3/TNFSF14/SIVA1 10 MF GO:0019957 C-C chemokine binding 7/1104 24/17697 0.0004877 0.01334 0.01131 CXCR4/CCR7/CCR5/CX3CR1/CCR2/CXCR6/CCR6 7 MF GO:0031994 insulin-like growth factor I binding 5/1104 12/17697 0.0005123 0.01334 0.01131 ITGAV/INSR/IGFBP6/IGFBP2/IGFBP5 5 MF GO:0032036 myosin heavy chain binding 5/1104 12/17697 0.0005123 0.01334 0.01131 CORO1A/AXL/MYL2/MYL9/MYL3 5 MF GO:0048018 receptor ligand activity 49/1104 482/17697 0.0005164 0.01334 0.01131 SPP1/CCL5/CXCL13/CCL13/SEMA5A/TGFA/TGFB2/VEGFA/IL32/SEMA3E/ADIPOQ/SEMA3A/IL1RN/HBEGF/STC1/IL1B/CCL18/NAMPT/BTC/CXCL8/NMB/TNFSF10/SECTM1/CXCL1/PTHLH/GAS6/SEMA3C/CXCL6/SEMA4F/BMP4/EFNA5/NTF3/GMFG/EFEMP1/PF4/CXCL3/NGF/CXCL10/GDF10/CXCL12/THBS4/SAA4/TNFSF14/CCL2/TYMP/INHBB/CCL7/CRLF1/IL15 49 MF GO:0061134 peptidase regulator activity 27/1104 219/17697 0.0005518 0.01388 0.01177 SERPINE2/SPOCK2/SLPI/SERPINA1/TIMP4/BIRC3/RARRES1/APLP2/CTSC/NOL3/CST7/CD27/GAS6/TIMP2/PTTG1/TFPI/CTSH/SERPINB8/PINK1/TIMP3/BAD/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2/PCOLCE 27 MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/1104 56/17697 0.0005881 0.01442 0.01222 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/GPX1/LPO/GSTT1/PRDX2/HBE1 11 MF GO:0023023 MHC protein complex binding 7/1104 25/17697 0.0006411 0.01532 0.01299 LILRB2/CD8A/ANXA11/HLA-DOB/HLA-DMA/HLA-DMB/KLRD1 7 MF GO:0001637 G protein-coupled chemoattractant receptor activity 7/1104 26/17697 0.0008306 0.01848 0.01567 CXCR4/CCR7/CCR5/CX3CR1/CCR2/CXCR6/CCR6 7 MF GO:0004950 chemokine receptor activity 7/1104 26/17697 0.0008306 0.01848 0.01567 CXCR4/CCR7/CCR5/CX3CR1/CCR2/CXCR6/CCR6 7 MF GO:0016209 antioxidant activity 14/1104 86/17697 0.0008313 0.01848 0.01567 LTC4S/HBB/PTGS1/PXDN/GPX3/GPX4/S100A9/GPX1/NQO1/APOE/LPO/GSTT1/PRDX2/HBE1 14 MF GO:0017124 SH3 domain binding 18/1104 130/17697 0.001187 0.02578 0.02186 ADAM19/KHDRBS3/SH3BGR/SHANK2/SH2D2A/PTPN6/DOCK1/ARHGAP1/PLSCR1/HCLS1/DNM1/PTTG1/SKAP1/PTPN22/RAPGEF1/GPX1/ADAM12/INPP5D 18 MF GO:0004725 protein tyrosine phosphatase activity 15/1104 100/17697 0.001313 0.02781 0.02358 DUSP5/PTPN13/PTPN7/PTPN21/CDC25B/PTPN6/PTPRC/DUSP14/PTPN22/DUSP2/PTPRF/PTP4A3/DUSP3/PTPN2/PTPRE 15 MF GO:0004866 endopeptidase inhibitor activity 22/1104 175/17697 0.001338 0.02781 0.02358 SERPINE2/SPOCK2/SLPI/SERPINA1/TIMP4/BIRC3/RARRES1/APLP2/NOL3/CST7/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/TIMP3/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2 22 MF GO:0008013 beta-catenin binding 13/1104 82/17697 0.001616 0.03286 0.02786 FOXO1/TCF7/TCF7L2/SMAD3/CDH5/AR/DLG5/KANK1/PIN1/CTNNBIP1/CARM1/CDH2/CBY1 13 MF GO:0017147 Wnt-protein binding 8/1104 37/17697 0.001702 0.03391 0.02875 WIF1/AXL/SFRP4/FZD2/FZD7/LRP5/SFRP1/TYRO3 8 MF GO:0043177 organic acid binding 24/1104 205/17697 0.002212 0.04155 0.03523 FCN1/TNFAIP6/HBB/FABP4/GCHFR/ADIPOQ/GRHPR/PCK1/ID3/PAM/ASS1/S100A9/GOT2/CD44/PC/APOC1/ACOX2/GOT1/GLRB/SUSD5/PTGDS/RXRA/SELP/HBE1 24 MF GO:0030414 peptidase inhibitor activity 22/1104 182/17697 0.002217 0.04155 0.03523 SERPINE2/SPOCK2/SLPI/SERPINA1/TIMP4/BIRC3/RARRES1/APLP2/NOL3/CST7/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/TIMP3/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2 22 MF GO:0061135 endopeptidase regulator activity 22/1104 182/17697 0.002217 0.04155 0.03523 SERPINE2/SPOCK2/SLPI/SERPINA1/TIMP4/BIRC3/RARRES1/APLP2/NOL3/CST7/CD27/GAS6/TIMP2/PTTG1/TFPI/SERPINB8/TIMP3/NGF/SERPINE1/TNFSF14/SPINT2/TFPI2 22 MF GO:0017134 fibroblast growth factor binding 6/1104 23/17697 0.00234 0.04303 0.03648 TGFBR3/CXCL13/ITGAV/FGFR1/S100A13/FGFR3 6 MF GO:0005164 tumor necrosis factor receptor binding 7/1104 31/17697 0.002527 0.04557 0.03864 TNFSF10/TRAF1/TRAP1/STAT1/TRAF3/TNFSF14/SIVA1 7 MF GO:0005201 extracellular matrix structural constituent 20/1104 163/17697 0.002885 0.05108 0.04331 ADIPOQ/PXDN/MFAP4/THBS2/MXRA5/POSTN/IGFBP7/MGP/FBLN5/CHI3L1/COL1A1/LTBP4/EFEMP2/EFEMP1/LAMB2/TFPI2/PRG4/COL3A1/COL4A1/PCOLCE 20 MF GO:0005516 calmodulin binding 23/1104 200/17697 0.003388 0.05889 0.04993 PLCB1/CALD1/RGS1/PDE1A/EGFR/SPTBN1/MYH11/RGS2/MYH10/MYH2/MYH7/NRGN/CAMSAP2/UNC13B/SNTA1/MYO1B/TTN/KCNN3/WFS1/PPP3CC/MARCKSL1/ADCY1/GAP43 23 MF GO:0048407 platelet-derived growth factor binding 4/1104 11/17697 0.003488 0.05954 0.05048 COL1A1/PDGFRA/COL3A1/COL4A1 4 MF GO:0005154 epidermal growth factor receptor binding 7/1104 33/17697 0.003681 0.06174 0.05235 TGFA/HBEGF/BTC/PLSCR1/ITGA5/EFEMP1/HIP1 7 MF GO:0017022 myosin binding 11/1104 71/17697 0.004311 0.07105 0.06024 CXCR4/CALD1/CORO1A/GSN/AXL/MYL2/RAB27A/RALA/MYL9/MYL3/ACTA1 11 MF GO:0005070 SH3/SH2 adaptor activity 9/1104 52/17697 0.004487 0.07196 0.06101 SH2B2/CHN1/SH2D1A/SH3BGR/SH2D2A/ARHGAP1/SKAP1/SLA/LAT 9 MF GO:0031406 carboxylic acid binding 22/1104 193/17697 0.004559 0.07196 0.06101 FCN1/TNFAIP6/FABP4/GCHFR/ADIPOQ/GRHPR/PCK1/ID3/PAM/ASS1/S100A9/GOT2/CD44/PC/APOC1/ACOX2/GOT1/GLRB/SUSD5/PTGDS/RXRA/SELP 22 MF GO:0048020 CCR chemokine receptor binding 8/1104 43/17697 0.004591 0.07196 0.06101 CCL5/CXCL13/CCL13/CCL18/CCR2/STAT1/CCL2/CCL7 8 MF GO:0004721 phosphoprotein phosphatase activity 21/1104 182/17697 0.00478 0.07314 0.06201 PHLPP1/LCK/DUSP5/PPP1R3C/PTPN13/PTPN7/PTPN21/CDC25B/PTPN6/PTPRC/DUSP14/PTPN22/MINPP1/DUSP2/PTPRF/PTP4A3/DUSP3/PPM1A/PTPN2/PPP3CC/PTPRE 21 MF GO:0042578 phosphoric ester hydrolase activity 36/1104 367/17697 0.00482 0.07314 0.06201 PLCB1/CCL5/PDE1A/PHLPP1/LCK/DUSP5/PPP1R3C/ENPP1/PTPN13/PTPN7/PTPN21/HDDC2/CDC25B/PTPN6/CCR5/ALPL/PTPRC/PLD3/PLCG2/DUSP14/PTPN22/INPP5F/MINPP1/DUSP2/CA3/PDE9A/PTPRF/INPP5D/PTP4A3/DUSP3/PPM1A/PTPN2/MPPED2/PPP3CC/PTPRE/CHRM3 36 MF GO:0035325 Toll-like receptor binding 4/1104 12/17697 0.004975 0.07416 0.06288 S100A9/LY96/MYD88/TLR2 4 MF GO:0005080 protein kinase C binding 9/1104 53/17697 0.005112 0.07416 0.06288 GRK5/ITGAV/PRKCB/PLEK/HSPB1/NELL1/LDB3/ADCY6/PDLIM5 9 MF GO:0001664 G protein-coupled receptor binding 29/1104 280/17697 0.00512 0.07416 0.06288 FCN1/MAGI2/CCL5/CXCL13/CCL13/CCL18/S1PR1/ADORA1/CXCL8/GNA11/NMB/RALA/CXCL1/DNM1/CCR2/CXCL6/HOMER3/UCHL1/FZD7/PHB/PF4/CXCL3/STAT1/CXCL10/CXCL12/AGTR1/SFRP1/CCL2/CCL7 29 MF GO:0001530 lipopolysaccharide binding 7/1104 35/17697 0.005199 0.07418 0.06289 TRIL/PTAFR/LY96/CD14/TLR2/LBP/SELP 7 MF GO:0001968 fibronectin binding 6/1104 27/17697 0.005543 0.0768 0.06512 VEGFA/ITGAV/CTSL/ITGA4/IGFBP6/IGFBP5 6 MF GO:0045499 chemorepellent activity 6/1104 27/17697 0.005543 0.0768 0.06512 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F/EFNA5 6 MF GO:0019902 phosphatase binding 21/1104 185/17697 0.005766 0.07875 0.06677 FOXO1/MAGI2/EGFR/LILRB2/LCK/PPP1R3C/SMAD3/MAPK3/CTSC/CDH5/MFHAS1/SH3YL1/SKAP1/PDLIM4/BAD/STAT1/CSK/AKAP11/TRAF3/CDH2/IKBKE 21 MF GO:0002020 protease binding 16/1104 128/17697 0.006051 0.07897 0.06696 TNFAIP3/ITGAV/SERPINA1/TIMP4/BIN1/NOL3/TRIP4/COL1A1/TIMP2/PINK1/SELL/TTN/TIMP3/SERPINE1/COL3A1/ELANE 16 MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 16/1104 128/17697 0.006051 0.07897 0.06696 ADH1B/GRHPR/AKR1B1/ADH1A/ADH1C/KCNAB1/HADH/AKR7A2/AKR1B10/DHRS3/HSD11B2/PGD/ALDH3A2/IMPDH1/IMPDH2/UGDH 16 MF GO:0030246 carbohydrate binding 28/1104 271/17697 0.006069 0.07897 0.06696 FCN1/GALNT10/LOXL2/CLEC10A/SLC2A3/ENPP1/CHI3L2/MLEC/PFKM/LGALS2/HK2/MAN2B2/PAM/CHI3L1/KLRB1/SIGLEC6/SELL/SLC2A5/OLR1/APCS/GANAB/CD72/PRG4/KLRD1/SELP/CD69/ALDOA/NPTX2 28 MF GO:0042169 SH2 domain binding 7/1104 36/17697 0.006113 0.07897 0.06696 LCK/DAG1/PTPN6/FGFR1/SKAP1/DLC1/ARHGAP5 7 MF GO:0004674 protein serine/threonine kinase activity 41/1104 439/17697 0.006444 0.08171 0.06928 TGFBR3/GRK5/CDK14/EGFR/CDK10/AKT3/PRKCB/CDC42BPA/DCLK1/PTK2B/PAK1/MAPK3/SIK1/MAP3K4/SRPK3/STK17B/CLK1/PAK2/PLK2/NEK1/DYRK2/LTBP4/PINK1/STK10/PIM1/MAP4K1/CDK4/MAPK7/TTN/MAPK10/PRKG1/PIM2/PRKCH/BMPR1A/MAPK13/CDK8/PLK1/FASTK/ICK/IKBKE/PRKY 41 MF GO:0008329 signaling pattern recognition receptor activity 5/1104 20/17697 0.006604 0.08171 0.06928 FCN1/PTAFR/LY96/CD14/TLR2 5 MF GO:0015631 tubulin binding 33/1104 336/17697 0.006634 0.08171 0.06928 ARL4C/CRYAB/MTUS2/MAPRE2/NDRG1/NCALD/EML1/KIF3B/DAG1/DST/MAPRE3/S100A9/RGS2/MID2/DNM1/GABARAPL1/SKAP1/GPAA1/CAV3/UNC5C/CAMSAP2/MX2/CETN2/STMN2/MTUS1/MAP4/SPAG5/PLK1/TUBGCP4/DPYSL2/VAPA/ALDOA/ATF5 33 MF GO:0030507 spectrin binding 6/1104 28/17697 0.00669 0.08171 0.06928 ANK3/EPB41L2/PTPRC/CAMSAP2/GBP1/DCTN2 6 MF GO:0004857 enzyme inhibitor activity 36/1104 375/17697 0.006752 0.08171 0.06928 SERPINE2/ARL2/RHOH/GCHFR/SPOCK2/SLPI/SERPINA1/TIMP4/BIRC3/RARRES1/PLN/HSPB1/APLP2/NOL3/CDKN2C/TRIB2/CST7/PKIG/CD27/GAS6/TIMP2/PTTG1/TFPI/APOC1/MGAT5/SERPINB8/PPP1R2/GMFG/TIMP3/NGF/SERPINE1/PPP1R1A/TNFSF14/SPINT2/TFPI2/GLMN 36 MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 15/1104 119/17697 0.007149 0.08543 0.07243 ADH1B/GRHPR/AKR1B1/ADH1A/ADH1C/KCNAB1/HADH/AKR7A2/AKR1B10/DHRS3/HSD11B2/PGD/IMPDH1/IMPDH2/UGDH 15 MF GO:0043621 protein self-association 9/1104 56/17697 0.007399 0.08732 0.07403 TNFAIP3/CCL5/ADAM8/CD2/GPSM2/CTSC/MYD88/ID1/TTN 9 MF GO:0001085 RNA polymerase II transcription factor binding 18/1104 155/17697 0.008042 0.09366 0.07941 EGR2/TCF7L2/TP53BP1/SMAD3/ID3/PITX1/ID1/HCLS1/AR/ERCC1/ID4/HDAC1/RERE/ZMIZ1/FBL/HDAC4/SPEN/JUN 18 MF GO:0004602 glutathione peroxidase activity 5/1104 21/17697 0.00823 0.09366 0.07941 LTC4S/GPX3/GPX4/GPX1/GSTT1 5 MF GO:0038187 pattern recognition receptor activity 5/1104 21/17697 0.00823 0.09366 0.07941 FCN1/PTAFR/LY96/CD14/TLR2 5 MF GO:0019887 protein kinase regulator activity 20/1104 180/17697 0.008737 0.09826 0.08331 CCL5/RAC2/DAXX/HSPB1/CCND2/CKS1B/CCND1/CDKN2C/TRIB2/PAK2/PKIG/GAS6/CCNA2/EFNA5/CDK4/CCNB1/GMFG/NCKAP1L/CXCL10/CCNB2 20 MF GO:0004707 MAP kinase activity 4/1104 14/17697 0.009103 0.1012 0.08579 MAPK3/MAPK7/MAPK10/MAPK13 4 MF GO:0043548 phosphatidylinositol 3-kinase binding 6/1104 30/17697 0.009482 0.1042 0.08834 CORO1A/AXL/LCK/PTPN13/INSR/TYRO3 6 MF GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/1104 49/17697 0.01027 0.1116 0.09463 CCND2/CKS1B/CCND1/CDKN2C/CCNA2/CDK4/CCNB1/CCNB2 8 MF GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 40/1104 439/17697 0.01048 0.1125 0.0954 CREB3L2/LITAF/EGR2/HOXA10/HLF/SIX1/NFIB/IRF1/GATA3/NFKB2/MEOX1/SMAD3/ZIC1/BATF/PITX1/NFKB1/STAT4/KLF6/CRX/RFX5/PLSCR1/SMAD1/AR/GATA2/HOXA5/HIF1A/NFIC/ATF6/NFIA/ELF4/NFE2L1/STAT1/MAFF/FOXC1/FOSL2/TFAP4/IER2/TCF15/ATF5/JUN 40 MF GO:0046332 SMAD binding 11/1104 80/17697 0.01062 0.1128 0.09562 TGFBR3/MAGI2/SMAD3/SMAD1/LDLRAD4/PURA/BMPR1A/PPM1A/COL3A1/SMAD6/JUN 11 MF GO:0001846 opsonin binding 4/1104 15/17697 0.01181 0.1227 0.104 ITGAV/PHB/APCS/ITGB2 4 MF GO:0033549 MAP kinase phosphatase activity 4/1104 15/17697 0.01181 0.1227 0.104 DUSP5/DUSP14/DUSP2/DUSP3 4 MF GO:0030215 semaphorin receptor binding 5/1104 23/17697 0.01227 0.1248 0.1058 SEMA5A/SEMA3E/SEMA3A/SEMA3C/SEMA4F 5 MF GO:0070412 R-SMAD binding 5/1104 23/17697 0.01227 0.1248 0.1058 SMAD3/LDLRAD4/PPM1A/SMAD6/JUN 5 MF GO:0008022 protein C-terminus binding 20/1104 187/17697 0.013 0.1308 0.1109 ZBTB16/CORO1A/LCK/MDC1/PTK2B/PFKM/GPSM2/SDC1/DST/MAPRE3/FBLN5/ID1/DNM1/SASH1/ERCC1/CAV3/PHB/USP7/CSK/NCF2 20 MF GO:0004197 cysteine-type endopeptidase activity 14/1104 116/17697 0.0132 0.1314 0.1114 CTSC/USP11/CTSL/CTSH/CASP4/CTSF/UCHL1/USP7/USP46/CAPNS1/CASP7/LGMN/SFRP1/USP5 14 MF GO:0019903 protein phosphatase binding 16/1104 140/17697 0.01386 0.1363 0.1155 FOXO1/EGFR/LILRB2/LCK/PPP1R3C/CDH5/MFHAS1/SKAP1/PDLIM4/BAD/STAT1/CSK/AKAP11/TRAF3/CDH2/IKBKE 16 MF GO:0035257 nuclear hormone receptor binding 17/1104 152/17697 0.01397 0.1363 0.1155 HMGA1/PRKCB/TCF7L2/SMAD3/DAXX/CNOT1/CRX/TRIP4/SMARCD3/HIF1A/ETS2/TACC2/TADA3/STAT1/KAT5/RXRA/UBA3 17 MF GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/1104 42/17697 0.01429 0.1364 0.1157 BIRC3/NOL3/CD27/GAS6/CTSH/BAD/TNFSF14 7 MF GO:0019865 immunoglobulin binding 5/1104 24/17697 0.01472 0.1364 0.1157 MS4A2/FCGR2B/FCGRT/LILRA2/FCGR2A 5 MF GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/1104 16/17697 0.01498 0.1364 0.1157 MAOA/LOXL2/AOC3/LOXL1 4 MF GO:0023026 MHC class II protein complex binding 4/1104 16/17697 0.01498 0.1364 0.1157 ANXA11/HLA-DOB/HLA-DMA/HLA-DMB 4 MF GO:0043395 heparan sulfate proteoglycan binding 4/1104 16/17697 0.01498 0.1364 0.1157 LPL/SEMA5A/PTPRC/APOE 4 MF GO:0070402 NADPH binding 4/1104 16/17697 0.01498 0.1364 0.1157 GRHPR/KCNAB1/LBR/QDPR 4 MF GO:0071837 HMG box domain binding 4/1104 16/17697 0.01498 0.1364 0.1157 EGR2/GATA3/MEOX1/JUN 4 MF GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/1104 43/17697 0.01618 0.1459 0.1237 ALDH6A1/AKR1B1/BCKDHA/ALDH5A1/ALDH3B1/AKR1B10/ALDH3A2 7 MF GO:0005504 fatty acid binding 6/1104 34/17697 0.01739 0.1533 0.13 FABP4/ID3/S100A9/APOC1/ACOX2/PTGDS 6 MF GO:0005543 phospholipid binding 38/1104 427/17697 0.01744 0.1533 0.13 PLCB1/GRK5/AGAP1/AXL/RASGRP1/BIN1/CPNE1/PLEK/GAB2/PTAFR/GOT2/ANXA11/SPTBN1/ESYT1/ZCCHC14/ABCG1/ARHGAP26/GAS6/SH3YL1/SYT17/APOC1/GPAA1/THY1/NRGN/UNC13B/FZD7/MYO1B/PLA2G7/HIP1/BAD/APOE/SNX7/SNAP91/WDR45/PFN2/PLA2G15/PSD4/GAP43 38 MF GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/1104 25/17697 0.01748 0.1533 0.13 BIRC3/NOL3/CD27/GAS6/TNFSF14 5 MF GO:1901618 organic hydroxy compound transmembrane transporter activity 7/1104 44/17697 0.01823 0.155 0.1314 ABCC3/SLC5A3/RBP4/AQP9/ABCG1/AQP1/SLC18A2 7 MF GO:0016791 phosphatase activity 26/1104 270/17697 0.01854 0.155 0.1314 PHLPP1/LCK/DUSP5/PPP1R3C/PTPN13/PTPN7/PTPN21/HDDC2/CDC25B/PTPN6/ALPL/PTPRC/DUSP14/PTPN22/INPP5F/MINPP1/DUSP2/CA3/PTPRF/INPP5D/PTP4A3/DUSP3/PPM1A/PTPN2/PPP3CC/PTPRE 26 MF GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1104 17/17697 0.01864 0.155 0.1314 PTPN6/PTPRC/PTPRF/PTPRE 4 MF GO:0019198 transmembrane receptor protein phosphatase activity 4/1104 17/17697 0.01864 0.155 0.1314 PTPN6/PTPRC/PTPRF/PTPRE 4 MF GO:0051010 microtubule plus-end binding 4/1104 17/17697 0.01864 0.155 0.1314 MAPRE2/DST/MAPRE3/SKAP1 4 MF GO:0070628 proteasome binding 4/1104 17/17697 0.01864 0.155 0.1314 SACS/ID1/RAD23B/WFS1 4 MF GO:0019207 kinase regulator activity 21/1104 207/17697 0.01921 0.1583 0.1342 CCL5/RAC2/RHOH/DAXX/HSPB1/CCND2/CKS1B/CCND1/CDKN2C/TRIB2/PAK2/PKIG/GAS6/CCNA2/EFNA5/CDK4/CCNB1/GMFG/NCKAP1L/CXCL10/CCNB2 21 MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/1104 35/17697 0.01991 0.1583 0.1342 ALDH6A1/AKR1B1/ALDH5A1/ALDH3B1/AKR1B10/ALDH3A2 6 MF GO:0016831 carboxy-lyase activity 6/1104 35/17697 0.01991 0.1583 0.1342 PCK1/BCKDHA/HDC/GOT1/UROD/PCK2 6 MF GO:0004033 aldo-keto reductase (NADP) activity 5/1104 26/17697 0.02056 0.1583 0.1342 AKR1B1/KCNAB1/AKR7A2/AKR1B10/DHRS3 5 MF GO:0004435 phosphatidylinositol phospholipase C activity 5/1104 26/17697 0.02056 0.1583 0.1342 PLCB1/CCL5/CCR5/PLCG2/CHRM3 5 MF GO:0002039 p53 binding 9/1104 66/17697 0.02082 0.1583 0.1342 NTRK3/EEF2/TP53BP1/DAXX/HIF1A/HDAC1/EHMT2/USP7/PTTG1IP 9 MF GO:0004016 adenylate cyclase activity 3/1104 10/17697 0.02087 0.1583 0.1342 ADCY9/ADCY6/ADCY1 3 MF GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity 3/1104 10/17697 0.02087 0.1583 0.1342 SMAD3/SMAD1/SMAD6 3 MF GO:0005165 neurotrophin receptor binding 3/1104 10/17697 0.02087 0.1583 0.1342 EFNA5/NTF3/NGF 3 MF GO:0070016 armadillo repeat domain binding 3/1104 10/17697 0.02087 0.1583 0.1342 TCF7L2/CNOT1/CTNNBIP1 3 MF GO:0071723 lipopeptide binding 3/1104 10/17697 0.02087 0.1583 0.1342 CD14/TLR2/LBP 3 MF GO:0051287 NAD binding 8/1104 56/17697 0.0221 0.1651 0.14 GRHPR/CYB5R3/HADH/AHCY/HSD11B2/QDPR/NDUFV1/UGDH 8 MF GO:0003823 antigen binding 17/1104 160/17697 0.02211 0.1651 0.14 TRBC1/IL7R/TAP1/CD48/SLAMF1/LILRA3/LILRB4/LILRA2/SLC7A8/ITGA4/SLC7A5/IGKC/LAG3/IGLV6-57/TAPBP/IGLC1/KLRD1 17 MF GO:0051427 hormone receptor binding 19/1104 185/17697 0.02236 0.1652 0.1401 FABP4/HMGA1/PRKCB/TCF7L2/SMAD3/DAXX/CNOT1/CRX/PTHLH/TRIP4/SMARCD3/HIF1A/ETS2/TACC2/TADA3/STAT1/KAT5/RXRA/UBA3 19 MF GO:0043394 proteoglycan binding 6/1104 36/17697 0.02267 0.1652 0.1401 LPL/SEMA5A/PTPRC/CTSL/APOE/PTPRF 6 MF GO:0001883 purine nucleoside binding 34/1104 381/17697 0.02271 0.1652 0.1401 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/ADA/RHOBTB3/EEF2/ADORA1/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 34 MF GO:0038191 neuropilin binding 4/1104 18/17697 0.02281 0.1652 0.1401 SEMA3E/SEMA3A/SEMA3C/SEMA4F 4 MF GO:0016829 lyase activity 19/1104 187/17697 0.02469 0.1774 0.1504 CA12/LTC4S/PCK1/ADCY9/ECI1/ECHS1/PAM/CD38/ADCY6/BCKDHA/HDC/PCBD1/GOT1/UROD/CA3/SDS/ALDOA/PCK2/ADCY1 19 MF GO:0004620 phospholipase activity 12/1104 102/17697 0.02489 0.1776 0.1505 PLCB1/LPL/CCL5/PNPLA6/CCR5/LIPC/PLD3/PLCG2/PLA2G7/PLA2G15/LYPLA1/CHRM3 12 MF GO:0015144 carbohydrate transmembrane transporter activity 6/1104 37/17697 0.02567 0.1818 0.1541 SLC2A3/SLC5A3/SLC23A2/AQP9/AQP1/SLC2A5 6 MF GO:0035591 signaling adaptor activity 10/1104 80/17697 0.02667 0.1828 0.155 SH2B2/CHN1/SH2D1A/SH3BGR/SH2D2A/GAB2/ARHGAP1/SKAP1/SLA/LAT 10 MF GO:0030971 receptor tyrosine kinase binding 9/1104 69/17697 0.02704 0.1828 0.155 SH2B2/ANGPT1/ITGAX/CD2/GAB2/GAS6/DUSP3/PTPN2/ANGPT2 9 MF GO:0017166 vinculin binding 3/1104 11/17697 0.02738 0.1828 0.155 SYNM/DAG1/ACTN1 3 MF GO:0019864 IgG binding 3/1104 11/17697 0.02738 0.1828 0.155 FCGR2B/FCGRT/FCGR2A 3 MF GO:0035197 siRNA binding 3/1104 11/17697 0.02738 0.1828 0.155 MECP2/FAM172A/MBD2 3 MF GO:0052650 NADP-retinol dehydrogenase activity 3/1104 11/17697 0.02738 0.1828 0.155 AKR1B1/AKR1B10/DHRS3 3 MF GO:0030296 protein tyrosine kinase activator activity 4/1104 19/17697 0.02751 0.1828 0.155 CCL5/PAK2/GAS6/EFNA5 4 MF GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/1104 19/17697 0.02751 0.1828 0.155 MAGI2/CDH5/BMP4/SMAD6 4 MF GO:0003785 actin monomer binding 5/1104 28/17697 0.02773 0.1828 0.155 CORO1A/MYL2/MYL3/COBL/PFN2 5 MF GO:0004629 phospholipase C activity 5/1104 28/17697 0.02773 0.1828 0.155 PLCB1/CCL5/CCR5/PLCG2/CHRM3 5 MF GO:1990841 promoter-specific chromatin binding 7/1104 48/17697 0.02829 0.1852 0.1571 PCGF2/NFE2L1/HDAC1/EHMT2/STAT1/HDAC4/FOXC1 7 MF GO:0042056 chemoattractant activity 6/1104 38/17697 0.02893 0.1881 0.1595 CCL5/VEGFA/BMP4/NTF3/CXCL10/SAA4 6 MF GO:0005507 copper ion binding 8/1104 59/17697 0.02933 0.1895 0.1606 LOXL2/AOC3/PAM/S100A13/MOXD1/CP/F8/LOXL1 8 MF GO:0001882 nucleoside binding 34/1104 389/17697 0.02958 0.1898 0.1609 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/ADA/RHOBTB3/EEF2/ADORA1/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 34 MF GO:1990782 protein tyrosine kinase binding 11/1104 93/17697 0.02985 0.1903 0.1613 CD247/SH2B2/ANGPT1/ITGAX/CD2/GAB2/CDH5/GAS6/DUSP3/PTPN2/ANGPT2 11 MF GO:0003924 GTPase activity 29/1104 324/17697 0.03224 0.2019 0.1712 RAC2/ARL4C/ARL2/RHOH/RGS1/AGAP1/RHOBTB3/EEF2/GCH1/RAB27A/GNA11/RALA/RGS2/RAB29/RGS13/DNM1/ARHGDIB/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/NRAS/GNG12 29 MF GO:0004745 retinol dehydrogenase activity 4/1104 20/17697 0.03273 0.2019 0.1712 ADH1B/ADH1A/ADH1C/DHRS3 4 MF GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/1104 20/17697 0.03273 0.2019 0.1712 MAOA/LOXL2/AOC3/LOXL1 4 MF GO:0016922 nuclear receptor binding 4/1104 20/17697 0.03273 0.2019 0.1712 TRIP4/TADA3/RXRA/UBA3 4 MF GO:0042288 MHC class I protein binding 4/1104 20/17697 0.03273 0.2019 0.1712 LILRB2/TAP1/CD8A/TAPBP 4 MF GO:0001158 enhancer sequence-specific DNA binding 13/1104 119/17697 0.03441 0.2082 0.1766 ZBTB16/RELB/HMGA1/GATA3/XBP1/NFKB1/GATA2/HOXA5/NFE2L1/HDAC1/IRF7/JUN/MBD2 13 MF GO:0017154 semaphorin receptor activity 3/1104 12/17697 0.03485 0.2082 0.1766 PLXNC1/PLXNA2/NRP2 3 MF GO:0030898 actin-dependent ATPase activity 3/1104 12/17697 0.03485 0.2082 0.1766 MYH10/MYH7/MYO1B 3 MF GO:0033691 sialic acid binding 3/1104 12/17697 0.03485 0.2082 0.1766 FCN1/ADIPOQ/SELP 3 MF GO:0070410 co-SMAD binding 3/1104 12/17697 0.03485 0.2082 0.1766 SMAD3/SMAD1/SMAD6 3 MF GO:0042287 MHC protein binding 6/1104 40/17697 0.03623 0.2143 0.1817 LILRB2/TAP1/CD8A/LAG3/TAPBP/KLRD1 6 MF GO:0097472 cyclin-dependent protein kinase activity 5/1104 30/17697 0.03632 0.2143 0.1817 CDK14/CDK10/CCNA2/CDK4/CDK8 5 MF GO:0030674 protein binding, bridging 17/1104 170/17697 0.03683 0.2152 0.1825 SH2B2/SORBS2/ANK3/CHN1/SH2D1A/SH3BGR/CUX1/SH2D2A/GAB2/ARHGAP1/GAS6/SKAP1/TEX261/HIP1/SLA/HERPUD1/LAT 17 MF GO:0005160 transforming growth factor beta receptor binding 7/1104 51/17697 0.03792 0.2152 0.1825 TGFBR3/TGFB2/SMAD3/BMP4/GDF10/SMAD6/INHBB 7 MF GO:0016830 carbon-carbon lyase activity 7/1104 51/17697 0.03792 0.2152 0.1825 PCK1/BCKDHA/HDC/GOT1/UROD/ALDOA/PCK2 7 MF GO:0045309 protein phosphorylated amino acid binding 7/1104 51/17697 0.03792 0.2152 0.1825 LCK/MAPK3/PTPN6/PLCG2/PIN1/SCAF8/VAV1 7 MF GO:0035326 enhancer binding 14/1104 133/17697 0.03799 0.2152 0.1825 ZBTB16/RELB/HMGA1/GATA3/SMAD3/XBP1/NFKB1/GATA2/HOXA5/NFE2L1/HDAC1/IRF7/JUN/MBD2 14 MF GO:0001848 complement binding 4/1104 21/17697 0.0385 0.2152 0.1825 CFB/PHB/APCS/ITGB2 4 MF GO:0008106 alcohol dehydrogenase (NADP+) activity 4/1104 21/17697 0.0385 0.2152 0.1825 AKR1B1/AKR7A2/AKR1B10/DHRS3 4 MF GO:0008483 transaminase activity 4/1104 21/17697 0.0385 0.2152 0.1825 GOT2/GFPT1/BCAT1/GOT1 4 MF GO:0051861 glycolipid binding 4/1104 21/17697 0.0385 0.2152 0.1825 GPAA1/THY1/SELL/SELP 4 MF GO:0070851 growth factor receptor binding 14/1104 134/17697 0.04009 0.2228 0.1889 TGFA/VEGFA/IL1RN/HBEGF/GATA3/IL1B/BTC/CDH5/PLSCR1/ITGA5/EFEMP1/HIP1/PDGFRA/GLMN 14 MF GO:0045296 cadherin binding 29/1104 331/17697 0.04084 0.2257 0.1913 PARVA/CALD1/PDLIM1/EGFR/ANK3/FNBP1L/NDRG1/FLNB/PPL/EEF2/HDLBP/ARHGAP1/SPTBN1/HSPA5/CDH5/PAK2/CAPG/ERC1/MYO1B/SND1/STAT1/CTTN/KTN1/PDLIM5/CDH2/EEF1D/VAPA/ALDOA/CCNB2 29 MF GO:0050662 coenzyme binding 26/1104 291/17697 0.04161 0.2286 0.1938 ALDH6A1/GRHPR/CYB5R1/GCH1/CYB5R3/PAM/PYGM/PYGB/GOT2/ACADS/KCNAB1/HADH/PC/HDC/ACOX2/GOT1/PPOX/LBR/AHCY/HSD11B2/PGD/QDPR/CRYM/NDUFV1/SDS/UGDH 26 MF GO:0004032 alditol:NADP+ 1-oxidoreductase activity 3/1104 13/17697 0.04326 0.231 0.1959 AKR1B1/AKR7A2/AKR1B10 3 MF GO:0005172 vascular endothelial growth factor receptor binding 3/1104 13/17697 0.04326 0.231 0.1959 VEGFA/CDH5/ITGA5 3 MF GO:0016208 AMP binding 3/1104 13/17697 0.04326 0.231 0.1959 PFKM/CYB5R3/MPPED2 3 MF GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/1104 13/17697 0.04326 0.231 0.1959 CYB5R1/CYB5R3/NQO1 3 MF GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/1104 13/17697 0.04326 0.231 0.1959 DUSP5/DUSP14/DUSP2 3 MF GO:0033293 monocarboxylic acid binding 8/1104 64/17697 0.04471 0.2341 0.1985 FABP4/ID3/S100A9/PC/APOC1/ACOX2/PTGDS/RXRA 8 MF GO:0000146 microfilament motor activity 4/1104 22/17697 0.04481 0.2341 0.1985 MYH10/MYH2/MYH7/MYO1B 4 MF GO:0015145 monosaccharide transmembrane transporter activity 4/1104 22/17697 0.04481 0.2341 0.1985 SLC2A3/SLC5A3/SLC23A2/SLC2A5 4 MF GO:0016849 phosphorus-oxygen lyase activity 4/1104 22/17697 0.04481 0.2341 0.1985 ADCY9/CD38/ADCY6/ADCY1 4 MF GO:0043130 ubiquitin binding 9/1104 76/17697 0.0464 0.2411 0.2044 TNFAIP3/CXCR4/SMAD3/HSPB1/CKS1B/UCHL1/RAD23B/USP5/IKBKG 9 MF GO:0008083 growth factor activity 16/1104 163/17697 0.04827 0.2494 0.2115 TGFA/TGFB2/VEGFA/HBEGF/BTC/CXCL1/BMP4/NTF3/GMFG/EFEMP1/NGF/GDF10/CXCL12/THBS4/TYMP/INHBB 16 MF GO:0032550 purine ribonucleoside binding 32/1104 378/17697 0.04903 0.252 0.2137 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/RHOBTB3/EEF2/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 32 MF GO:0016769 transferase activity, transferring nitrogenous groups 4/1104 23/17697 0.05166 0.2577 0.2185 GOT2/GFPT1/BCAT1/GOT1 4 MF GO:0030159 receptor signaling complex scaffold activity 4/1104 23/17697 0.05166 0.2577 0.2185 MAGI2/SHANK2/CD3G/DLG5 4 MF GO:0009055 electron transfer activity 12/1104 114/17697 0.05203 0.2577 0.2185 LOXL2/AKR1B1/COX7A1/ASPH/AKR7A2/NQO1/COX6A2/DHRS3/QDPR/NCF2/UQCRC1/ETFB 12 MF GO:0019001 guanyl nucleotide binding 33/1104 394/17697 0.05216 0.2577 0.2185 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/RHOBTB3/EEF2/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/PRKG1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 33 MF GO:0032561 guanyl ribonucleotide binding 33/1104 394/17697 0.05216 0.2577 0.2185 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/RHOBTB3/EEF2/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/PRKG1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 33 MF GO:0005344 oxygen carrier activity 3/1104 14/17697 0.05257 0.2577 0.2185 HBB/MB/HBE1 3 MF GO:0035497 cAMP response element binding 3/1104 14/17697 0.05257 0.2577 0.2185 CREB3L2/ATF6/JUN 3 MF GO:0050998 nitric-oxide synthase binding 3/1104 14/17697 0.05257 0.2577 0.2185 DNM1/CAV3/SNTA1 3 MF GO:0052745 inositol phosphate phosphatase activity 3/1104 14/17697 0.05257 0.2577 0.2185 INPP5F/MINPP1/INPP5D 3 MF GO:0005200 structural constituent of cytoskeleton 11/1104 102/17697 0.05297 0.2583 0.219 SYNM/SORBS2/ANK3/PPL/DES/TLN2/SPTBN1/ACTA1/HIP1/ARPC3/TUBGCP4 11 MF GO:0001540 amyloid-beta binding 9/1104 78/17697 0.05328 0.2583 0.219 CRYAB/TGFB2/LILRB2/CLSTN1/FCGR2B/INSR/TLR2/APOE/ITGB2 9 MF GO:0016298 lipase activity 13/1104 127/17697 0.05349 0.2583 0.219 PLCB1/LPL/CCL5/PNPLA6/CCR5/LIPC/PLD3/PLCG2/PNPLA4/PLA2G7/PLA2G15/LYPLA1/CHRM3 13 MF GO:0032549 ribonucleoside binding 32/1104 382/17697 0.05506 0.2645 0.2243 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/RHOBTB3/EEF2/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/MPPED2/NRAS/PCK2 32 MF GO:0005518 collagen binding 8/1104 67/17697 0.0561 0.2681 0.2273 DDR2/SPOCK2/SMAD3/PAK1/CD44/CTSL/SPARCL1/PCOLCE 8 MF GO:0008017 microtubule binding 22/1104 246/17697 0.05676 0.27 0.2289 CRYAB/MTUS2/MAPRE2/NDRG1/EML1/KIF3B/DST/MAPRE3/S100A9/MID2/DNM1/SKAP1/CAMSAP2/MX2/CETN2/MTUS1/MAP4/SPAG5/PLK1/TUBGCP4/DPYSL2/VAPA 22 MF GO:0001965 G-protein alpha-subunit binding 4/1104 24/17697 0.05904 0.2781 0.2357 RGS1/GPSM2/RGS2/F2R 4 MF GO:0051119 sugar transmembrane transporter activity 4/1104 24/17697 0.05904 0.2781 0.2357 SLC2A3/SLC5A3/SLC23A2/SLC2A5 4 MF GO:0051117 ATPase binding 9/1104 80/17697 0.0608 0.2844 0.2411 LCK/PLN/RALA/PEX19/AR/SNTA1/UBE4B/FBL/WFS1 9 MF GO:0060589 nucleoside-triphosphatase regulator activity 29/1104 344/17697 0.06118 0.2844 0.2411 PLCB1/GPSM3/ARHGAP12/SIPA1L1/ARL2/RHOH/RGS1/AGAP1/CHN1/GPSM2/PLN/BAG1/DOCK1/ARHGAP1/RGS2/ARHGAP26/ATP4B/ARHGDIB/THY1/DLC1/ACAP1/NCKAP1L/TBC1D4/SGSM2/ABR/ARHGAP5/STARD8/NPRL3/JUN 29 MF GO:0005024 transforming growth factor beta-activated receptor activity 3/1104 15/17697 0.06277 0.2844 0.2411 TGFBR3/LTBP4/BMPR1A 3 MF GO:0005161 platelet-derived growth factor receptor binding 3/1104 15/17697 0.06277 0.2844 0.2411 VEGFA/ITGA5/PDGFRA 3 MF GO:0005523 tropomyosin binding 3/1104 15/17697 0.06277 0.2844 0.2411 CALD1/TMOD1/TNNT1 3 MF GO:0015929 hexosaminidase activity 3/1104 15/17697 0.06277 0.2844 0.2411 HEXA/HYAL1/NAGA 3 MF GO:0070492 oligosaccharide binding 3/1104 15/17697 0.06277 0.2844 0.2411 LOXL2/SELL/SELP 3 MF GO:0070742 C2H2 zinc finger domain binding 3/1104 15/17697 0.06277 0.2844 0.2411 GATA2/EHMT2/MBD2 3 MF GO:0030695 GTPase regulator activity 26/1104 304/17697 0.06388 0.288 0.2442 PLCB1/GPSM3/ARHGAP12/SIPA1L1/ARL2/RHOH/RGS1/AGAP1/CHN1/GPSM2/DOCK1/ARHGAP1/RGS2/ARHGAP26/ARHGDIB/THY1/DLC1/ACAP1/NCKAP1L/TBC1D4/SGSM2/ABR/ARHGAP5/STARD8/NPRL3/JUN 26 MF GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1104 46/17697 0.06477 0.2907 0.2465 ITK/LCK/PTK2B/CLK1/SLA/CSK 6 MF GO:0005525 GTP binding 31/1104 374/17697 0.06508 0.2907 0.2465 RAC2/ARL4C/ARL2/RHOH/AGAP1/PCK1/RHOBTB3/EEF2/GCH1/TGM2/RAB27A/GNA11/RALA/ARL4A/MFHAS1/RAB29/INSR/DNM1/EEF1A2/GBP2/MX2/RHOBTB1/GBP1/RAB22A/GSPT1/DRG2/ARF3/ARHGAP5/ARHGEF5/NRAS/PCK2 31 MF GO:0060090 molecular adaptor activity 21/1104 237/17697 0.06651 0.295 0.2501 SH2B2/SORBS2/ANK3/CHN1/SH2D1A/SH3BGR/CUX1/SH2D2A/GAB2/ARHGAP1/CNOT1/GAS6/SASH1/SKAP1/CAV3/AKAP9/TEX261/HIP1/SLA/HERPUD1/LAT 21 MF GO:0033612 receptor serine/threonine kinase binding 4/1104 25/17697 0.06696 0.295 0.2501 MAGI2/CDH5/BMP4/SMAD6 4 MF GO:0035586 purinergic receptor activity 4/1104 25/17697 0.06696 0.295 0.2501 P2RY6/ADORA3/ADORA1/PTAFR 4 MF GO:0008081 phosphoric diester hydrolase activity 10/1104 94/17697 0.0679 0.297 0.2518 PLCB1/CCL5/PDE1A/ENPP1/CCR5/PLD3/PLCG2/PDE9A/MPPED2/CHRM3 10 MF GO:0004869 cysteine-type endopeptidase inhibitor activity 7/1104 58/17697 0.06805 0.297 0.2518 BIRC3/NOL3/CST7/CD27/GAS6/PTTG1/TNFSF14 7 MF GO:0005496 steroid binding 10/1104 95/17697 0.07187 0.3123 0.2648 PGRMC2/NR3C2/GPR183/NPC1/ABCG1/AR/NFE2L1/HSD11B2/APOE/APOF 10 MF GO:0051219 phosphoprotein binding 9/1104 83/17697 0.07329 0.317 0.2688 TOX3/LCK/MAPK3/PTPN6/MID2/PLCG2/PIN1/SCAF8/VAV1 9 MF GO:0051019 mitogen-activated protein kinase binding 4/1104 26/17697 0.0754 0.3247 0.2753 GCH1/PTAFR/MAPK7/DUSP2 4 MF GO:0032182 ubiquitin-like protein binding 10/1104 96/17697 0.07597 0.3257 0.2761 TNFAIP3/CXCR4/SMAD3/DAXX/HSPB1/CKS1B/UCHL1/RAD23B/USP5/IKBKG 10 MF GO:0004364 glutathione transferase activity 4/1104 27/17697 0.08434 0.3516 0.2981 LTC4S/HPGDS/GSTA4/GSTT1 4 MF GO:0048306 calcium-dependent protein binding 7/1104 61/17697 0.08437 0.3516 0.2981 ANXA11/CASQ2/TNNC2/TNNC1/STMN2/WFS1/SELP 7 MF GO:0016504 peptidase activator activity 5/1104 38/17697 0.08547 0.3516 0.2981 CTSC/CTSH/PINK1/BAD/PCOLCE 5 MF GO:0043531 ADP binding 5/1104 38/17697 0.08547 0.3516 0.2981 TAP1/CYB5R3/MYH10/ABCG1/ACTA1 5 MF GO:0004551 nucleotide diphosphatase activity 3/1104 17/17697 0.08561 0.3516 0.2981 ENPP1/ASMTL/NUDT3 3 MF GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1104 17/17697 0.08561 0.3516 0.2981 TGFBR3/LTBP4/BMPR1A 3 MF GO:0005123 death receptor binding 3/1104 17/17697 0.08561 0.3516 0.2981 NOL3/MYD88/NGF 3 MF GO:0042813 Wnt-activated receptor activity 3/1104 17/17697 0.08561 0.3516 0.2981 FZD2/FZD7/LRP5 3 MF GO:0055106 ubiquitin-protein transferase regulator activity 3/1104 17/17697 0.08561 0.3516 0.2981 TRIB2/RING1/GLMN 3 MF GO:0004175 endopeptidase activity 34/1104 427/17697 0.08569 0.3516 0.2981 ADAM19/ADAM8/ADAMDEC1/GZMK/GZMB/CFB/CPNE1/CTSD/GZMA/CTSC/ADAMTS2/USP11/ADAMTS3/CTSL/CFD/CTSH/CASP4/CTSF/UCHL1/CFI/HTRA1/USP7/USP46/ADAM12/CAPNS1/ADAM28/CASP7/LGMN/SFRP1/USP5/ST14/GZMH/MMP15/ELANE 34 MF GO:0044325 ion channel binding 12/1104 124/17697 0.08621 0.3522 0.2986 ANK3/ACTN1/FXYD1/NEDD4L/CDH5/KCNAB1/CAV3/AKAP9/SNTA1/RIMS3/FHL1/HERPUD1 12 MF GO:0019003 GDP binding 8/1104 74/17697 0.08928 0.3632 0.3079 ARL2/PCK1/RAB27A/RALA/RAB29/GBP1/RAB22A/NRAS 8 MF GO:0030145 manganese ion binding 7/1104 62/17697 0.09027 0.3657 0.31 PCK1/MGAT5/DYRK2/PIM1/PPM1A/MPPED2/PCK2 7 MF GO:0003713 transcription coactivator activity 26/1104 319/17697 0.09867 0.398 0.3374 CD3D/WWTR1/HMGA1/PDLIM1/THRA/GATA3/PRKCB/NUPR1/NFKB2/ACTN1/DAXX/MAGED1/TRIP4/SMARCD3/PCBD1/ATF6/RERE/NFE2L3/JMJD6/ZMIZ1/TADA3/KAT5/FOXC1/CARM1/RXRA/JUN 26 MF GO:0001784 phosphotyrosine residue binding 5/1104 40/17697 0.1014 0.4073 0.3454 LCK/MAPK3/PTPN6/PLCG2/VAV1 5 MF GO:0050661 NADP binding 6/1104 52/17697 0.1035 0.4096 0.3473 GRHPR/KCNAB1/LBR/PGD/QDPR/CRYM 6 MF GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/1104 29/17697 0.1037 0.4096 0.3473 CDK14/CDK10/CDK4/CDK8 4 MF GO:0032947 protein-containing complex scaffold activity 4/1104 29/17697 0.1037 0.4096 0.3473 MAGI2/SHANK2/CD3G/DLG5 4 MF GO:0071889 14-3-3 protein binding 4/1104 29/17697 0.1037 0.4096 0.3473 SIK1/NEK1/BAD/DDIT4 4 MF GO:0003714 transcription corepressor activity 20/1104 238/17697 0.1078 0.424 0.3595 EZH1/MECP2/RELB/WWTR1/ZHX3/DAXX/ID3/CCND1/NACC2/SAP18/ZNF85/ID4/HDAC1/RERE/BASP1/HDAC4/SPEN/CRYM/ELANE/ATF5 20 MF GO:0004622 lysophospholipase activity 3/1104 19/17697 0.1114 0.433 0.3671 PNPLA6/PLA2G15/LYPLA1 3 MF GO:0016505 peptidase activator activity involved in apoptotic process 3/1104 19/17697 0.1114 0.433 0.3671 CTSC/CTSH/BAD 3 MF GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1104 19/17697 0.1114 0.433 0.3671 QDPR/CRYM/MTHFD2 3 MF GO:0008234 cysteine-type peptidase activity 16/1104 184/17697 0.1121 0.4338 0.3678 TNFAIP3/CTSC/USP11/CTSL/CTSH/CASP4/CTSF/UCHL1/USP7/USP46/EIF3F/CAPNS1/CASP7/LGMN/SFRP1/USP5 16 MF GO:0030170 pyridoxal phosphate binding 6/1104 54/17697 0.1186 0.4543 0.3852 PYGM/PYGB/GOT2/HDC/GOT1/SDS 6 MF GO:0070279 vitamin B6 binding 6/1104 54/17697 0.1186 0.4543 0.3852 PYGM/PYGB/GOT2/HDC/GOT1/SDS 6 MF GO:0030374 nuclear receptor transcription coactivator activity 7/1104 67/17697 0.1231 0.4543 0.3852 HMGA1/THRA/PRKCB/ACTN1/ZMIZ1/TADA3/CARM1 7 MF GO:0042605 peptide antigen binding 4/1104 31/17697 0.1248 0.4543 0.3852 TAP1/SLC7A8/SLC7A5/TAPBP 4 MF GO:0030295 protein kinase activator activity 8/1104 80/17697 0.1251 0.4543 0.3852 CCL5/DAXX/CKS1B/PAK2/GAS6/EFNA5/CCNB1/NCKAP1L 8 MF GO:0001091 RNA polymerase II basal transcription factor binding 3/1104 20/17697 0.1253 0.4543 0.3852 AR/ERCC1/FBL 3 MF GO:0003746 translation elongation factor activity 3/1104 20/17697 0.1253 0.4543 0.3852 EEF2/EEF1A2/EEF1D 3 MF GO:0005355 glucose transmembrane transporter activity 3/1104 20/17697 0.1253 0.4543 0.3852 SLC2A3/SLC5A3/SLC2A5 3 MF GO:0005385 zinc ion transmembrane transporter activity 3/1104 20/17697 0.1253 0.4543 0.3852 SLC39A8/SLC39A14/SLC39A7 3 MF GO:0015149 hexose transmembrane transporter activity 3/1104 20/17697 0.1253 0.4543 0.3852 SLC2A3/SLC5A3/SLC2A5 3 MF GO:0031683 G-protein beta/gamma-subunit complex binding 3/1104 20/17697 0.1253 0.4543 0.3852 ADORA1/GNA11/CETN2 3 MF GO:0004690 cyclic nucleotide-dependent protein kinase activity 2/1104 10/17697 0.1255 0.4543 0.3852 PRKG1/PRKY 2 MF GO:0004691 cAMP-dependent protein kinase activity 2/1104 10/17697 0.1255 0.4543 0.3852 PRKG1/PRKY 2 MF GO:0031078 histone deacetylase activity (H3-K14 specific) 2/1104 10/17697 0.1255 0.4543 0.3852 HDAC1/HDAC4 2 MF GO:0031720 haptoglobin binding 2/1104 10/17697 0.1255 0.4543 0.3852 HBB/HBE1 2 MF GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) 2/1104 10/17697 0.1255 0.4543 0.3852 HDAC1/HDAC4 2 MF GO:0051400 BH domain binding 2/1104 10/17697 0.1255 0.4543 0.3852 BCL2L2/BCL2A1 2 MF GO:0005096 GTPase activator activity 22/1104 273/17697 0.1313 0.473 0.401 PLCB1/ARHGAP12/SIPA1L1/RGS1/AGAP1/CHN1/DOCK1/ARHGAP1/RGS2/ARHGAP26/ARHGDIB/THY1/DLC1/ACAP1/NCKAP1L/TBC1D4/SGSM2/ABR/ARHGAP5/STARD8/NPRL3/JUN 22 MF GO:0004867 serine-type endopeptidase inhibitor activity 9/1104 94/17697 0.1316 0.473 0.401 SERPINE2/SLPI/SERPINA1/APLP2/TFPI/SERPINB8/SERPINE1/SPINT2/TFPI2 9 MF GO:0032934 sterol binding 6/1104 56/17697 0.1347 0.4769 0.4043 GPR183/NPC1/ABCG1/NFE2L1/APOE/APOF 6 MF GO:0019205 nucleobase-containing compound kinase activity 5/1104 44/17697 0.1373 0.4769 0.4043 DCK/AK1/NME3/GUK1/TK2 5 MF GO:0048365 Rac GTPase binding 7/1104 69/17697 0.1377 0.4769 0.4043 PAK1/PAK2/ARHGDIB/NCKAP1/NCKAP1L/VAV1/NCF2 7 MF GO:0004806 triglyceride lipase activity 3/1104 21/17697 0.1398 0.4769 0.4043 LPL/LIPC/PNPLA4 3 MF GO:0005540 hyaluronic acid binding 3/1104 21/17697 0.1398 0.4769 0.4043 TNFAIP6/CD44/SUSD5 3 MF GO:0019789 SUMO transferase activity 3/1104 21/17697 0.1398 0.4769 0.4043 EGR2/ZMIZ1/HDAC4 3 MF GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/1104 21/17697 0.1398 0.4769 0.4043 TNFAIP3/PRPF8/IKBKG 3 MF GO:0017048 Rho GTPase binding 15/1104 177/17697 0.1408 0.4769 0.4043 RHOH/ARHGEF10/KIF3B/PAK1/DNMBP/DOCK1/PAK2/ARHGDIB/TNFAIP1/NCKAP1/NCKAP1L/ABR/ARHGEF5/VAV1/NCF2 15 MF GO:0030276 clathrin binding 6/1104 57/17697 0.1431 0.4769 0.4043 NCALD/BIN1/SYT17/AP1B1/HIP1/SNAP91 6 MF GO:0050840 extracellular matrix binding 6/1104 57/17697 0.1431 0.4769 0.4043 SPP1/VEGFA/SPOCK2/ITGAV/DAG1/SPARCL1 6 MF GO:0008138 protein tyrosine/serine/threonine phosphatase activity 5/1104 45/17697 0.1471 0.4769 0.4043 DUSP5/DUSP14/DUSP2/PTP4A3/DUSP3 5 MF GO:0001094 TFIID-class transcription factor complex binding 2/1104 11/17697 0.1473 0.4769 0.4043 ERCC1/FBL 2 MF GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1104 11/17697 0.1473 0.4769 0.4043 PPP1R2/PPP1R1A 2 MF GO:0005035 death receptor activity 2/1104 11/17697 0.1473 0.4769 0.4043 TNFRSF1B/TNFRSF4 2 MF GO:0005324 long-chain fatty acid transporter activity 2/1104 11/17697 0.1473 0.4769 0.4043 FABP4/SLC27A2 2 MF GO:0005536 glucose binding 2/1104 11/17697 0.1473 0.4769 0.4043 SLC2A3/HK2 2 MF GO:0008097 5S rRNA binding 2/1104 11/17697 0.1473 0.4769 0.4043 EEF2/TST 2 MF GO:0008429 phosphatidylethanolamine binding 2/1104 11/17697 0.1473 0.4769 0.4043 ANXA11/ESYT1 2 MF GO:0015250 water channel activity 2/1104 11/17697 0.1473 0.4769 0.4043 AQP9/AQP1 2 MF GO:0016801 hydrolase activity, acting on ether bonds 2/1104 11/17697 0.1473 0.4769 0.4043 AKR7A2/AHCY 2 MF GO:0031996 thioesterase binding 2/1104 11/17697 0.1473 0.4769 0.4043 TRAF1/TRAF3 2 MF GO:0043422 protein kinase B binding 2/1104 11/17697 0.1473 0.4769 0.4043 PINK1/BAD 2 MF GO:0043522 leucine zipper domain binding 2/1104 11/17697 0.1473 0.4769 0.4043 CRX/ERC1 2 MF GO:0047429 nucleoside-triphosphate diphosphatase activity 2/1104 11/17697 0.1473 0.4769 0.4043 ENPP1/ASMTL 2 MF GO:0050786 RAGE receptor binding 2/1104 11/17697 0.1473 0.4769 0.4043 S100A9/S100A13 2 MF GO:0070411 I-SMAD binding 2/1104 11/17697 0.1473 0.4769 0.4043 SMAD1/SMAD6 2 MF GO:0070700 BMP receptor binding 2/1104 11/17697 0.1473 0.4769 0.4043 CDH5/BMP4 2 MF GO:0097493 structural molecule activity conferring elasticity 2/1104 11/17697 0.1473 0.4769 0.4043 FBLN5/TTN 2 MF GO:0071813 lipoprotein particle binding 4/1104 33/17697 0.1477 0.4769 0.4043 LPL/LIPC/APOE/APCS 4 MF GO:0071814 protein-lipid complex binding 4/1104 33/17697 0.1477 0.4769 0.4043 LPL/LIPC/APOE/APCS 4 MF GO:0001786 phosphatidylserine binding 6/1104 58/17697 0.1518 0.4869 0.4128 AXL/RASGRP1/CPNE1/GAS6/SYT17/GAP43 6 MF GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/1104 58/17697 0.1518 0.4869 0.4128 BLVRA/TECR/ACADS/ACOX2/PPOX/LBR 6 MF GO:0042826 histone deacetylase binding 10/1104 111/17697 0.1545 0.4899 0.4154 HOXA10/CCND1/NACC2/HIF1A/HDAC1/ZNHIT1/PHB/HDAC4/CAMTA2/TFAP4 10 MF GO:0009975 cyclase activity 3/1104 22/17697 0.1548 0.4899 0.4154 ADCY9/ADCY6/ADCY1 3 MF GO:0030742 GTP-dependent protein binding 3/1104 22/17697 0.1548 0.4899 0.4154 GCHFR/GCH1/UNC13B 3 MF GO:0050431 transforming growth factor beta binding 3/1104 22/17697 0.1548 0.4899 0.4154 TGFBR3/ITGAV/LTBP4 3 MF GO:0042277 peptide binding 23/1104 295/17697 0.1595 0.5011 0.4248 GPR1/CRYAB/TGFB2/LILRB2/CLSTN1/TAP1/FCGR2B/NFKBIA/PEX19/CD14/SLC7A8/INSR/SLC7A5/VIPR1/KDELR3/TLR2/KDELR1/APOE/LBP/TAPBP/TMEM158/ITGB2/RXRA 23 MF GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1104 34/17697 0.1596 0.5011 0.4248 ADA/GCH1/AMPD3/MTHFD2 4 MF GO:0038024 cargo receptor activity 8/1104 85/17697 0.1599 0.5011 0.4248 LOXL2/ENPP1/INSR/CFI/HIP1/TFRC/ITGB2/PRG4 8 MF GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 9/1104 99/17697 0.1644 0.5102 0.4325 ZBTB16/RELB/NFKB1/GATA2/HOXA5/NFE2L1/HDAC1/JUN/MBD2 9 MF GO:0019209 kinase activator activity 8/1104 86/17697 0.1673 0.5102 0.4325 CCL5/DAXX/CKS1B/PAK2/GAS6/EFNA5/CCNB1/NCKAP1L 8 MF GO:0016763 transferase activity, transferring pentosyl groups 5/1104 47/17697 0.1674 0.5102 0.4325 XYLT1/NAMPT/HPRT1/PARP3/TYMP 5 MF GO:0016860 intramolecular oxidoreductase activity 5/1104 47/17697 0.1674 0.5102 0.4325 ECH1/HPGDS/ECI1/MPI/PTGDS 5 MF GO:0001054 RNA polymerase I activity 2/1104 12/17697 0.1697 0.5102 0.4325 POLR2E/POLR1C 2 MF GO:0005372 water transmembrane transporter activity 2/1104 12/17697 0.1697 0.5102 0.4325 AQP9/AQP1 2 MF GO:0019992 diacylglycerol binding 2/1104 12/17697 0.1697 0.5102 0.4325 RASGRP1/UNC13B 2 MF GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1104 12/17697 0.1697 0.5102 0.4325 INPP5F/INPP5D 2 MF GO:0042301 phosphate ion binding 2/1104 12/17697 0.1697 0.5102 0.4325 MTHFD2/GNG12 2 MF GO:0042975 peroxisome proliferator activated receptor binding 2/1104 12/17697 0.1697 0.5102 0.4325 HMGA1/IKBKG 2 MF GO:0045295 gamma-catenin binding 2/1104 12/17697 0.1697 0.5102 0.4325 TCF7L2/CDH2 2 MF GO:0051011 microtubule minus-end binding 2/1104 12/17697 0.1697 0.5102 0.4325 CAMSAP2/TUBGCP4 2 MF GO:0001223 transcription coactivator binding 3/1104 23/17697 0.1702 0.5102 0.4325 FOXO1/SIX1/FOXC1 3 MF GO:0046625 sphingolipid binding 3/1104 23/17697 0.1702 0.5102 0.4325 S1PR1/SELL/SELP 3 MF GO:0042626 ATPase activity, coupled to transmembrane movement of substances 10/1104 115/17697 0.1806 0.5378 0.4559 ABCC3/ABCA8/TAP1/ABCA3/ABCG1/ATP4B/ATP2A1/ABCC5/TAPBP/ATP6V0D1 10 MF GO:0043492 ATPase activity, coupled to movement of substances 10/1104 115/17697 0.1806 0.5378 0.4559 ABCC3/ABCA8/TAP1/ABCA3/ABCG1/ATP4B/ATP2A1/ABCC5/TAPBP/ATP6V0D1 10 MF GO:0017080 sodium channel regulator activity 4/1104 36/17697 0.1845 0.5461 0.463 FXYD1/NEDD4L/CAV3/SNTA1 4 MF GO:0042562 hormone binding 9/1104 102/17697 0.1857 0.5461 0.463 EGFR/THRA/ADIPOR2/INSR/VIPR1/AR/CTSH/CRYM/CHRM3 9 MF GO:0051087 chaperone binding 9/1104 102/17697 0.1857 0.5461 0.463 SACS/BIN1/DNAJB5/BAG1/CTSC/HSPA5/PDPN/CP/HSPB6 9 MF GO:0072509 divalent inorganic cation transmembrane transporter activity 3/1104 24/17697 0.1861 0.5461 0.463 SLC39A8/SLC39A14/SLC39A7 3 MF GO:0048029 monosaccharide binding 7/1104 75/17697 0.1862 0.5461 0.463 SLC2A3/PFKM/HK2/PAM/SLC2A5/SELP/ALDOA 7 MF GO:0015485 cholesterol binding 5/1104 49/17697 0.1888 0.5517 0.4677 NPC1/ABCG1/NFE2L1/APOE/APOF 5 MF GO:0001608 G protein-coupled nucleotide receptor activity 2/1104 13/17697 0.1927 0.5517 0.4677 P2RY6/PTAFR 2 MF GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1104 13/17697 0.1927 0.5517 0.4677 SH2B2/GAB2 2 MF GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism 2/1104 13/17697 0.1927 0.5517 0.4677 ATP2A1/ATP6V0D1 2 MF GO:0016840 carbon-nitrogen lyase activity 2/1104 13/17697 0.1927 0.5517 0.4677 PAM/SDS 2 MF GO:0031434 mitogen-activated protein kinase kinase binding 2/1104 13/17697 0.1927 0.5517 0.4677 TRIB2/PIN1 2 MF GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/1104 13/17697 0.1927 0.5517 0.4677 P2RY6/PTAFR 2 MF GO:0045159 myosin II binding 2/1104 13/17697 0.1927 0.5517 0.4677 GSN/MYL3 2 MF GO:0005319 lipid transporter activity 11/1104 131/17697 0.1946 0.5554 0.4709 ABCC3/FABP4/ABCA8/RBP4/ABCA3/NPC1/PLSCR1/ABCG1/SLC27A2/APOE/APOF 11 MF GO:0004252 serine-type endopeptidase activity 13/1104 160/17697 0.1995 0.5668 0.4806 ADAM8/GZMK/GZMB/CFB/GZMA/CTSC/CFD/CTSH/CFI/HTRA1/ST14/GZMH/ELANE 13 MF GO:0070888 E-box binding 5/1104 50/17697 0.1998 0.5668 0.4806 GATA3/HIF1A/HDAC1/TWIST1/TFAP4 5 MF GO:0051213 dioxygenase activity 8/1104 91/17697 0.2068 0.5848 0.4958 FTO/PTGS1/HPD/ASPH/CDO1/JMJD6/ALOX5/ASPHD1 8