ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04062	Chemokine signaling pathway	41/668	192/8135	7.922e-09	1.62e-06	1.036e-06	PLCB1/CXCR4/GRK5/CCL5/RAC2/CXCL13/CCL13/ITK/AKT3/PRKCB/PTK2B/CCL18/CCR7/PAK1/ADCY9/MAPK3/CXCL8/NFKBIA/NFKB1/CCR5/CXCL1/PLCG2/CX3CR1/ADCY6/CCR2/CXCL6/CXCR6/CCR6/PF4/BAD/CXCL3/STAT1/CXCL10/CXCL12/VAV1/CCL2/NRAS/GNG12/IKBKG/CCL7/ADCY1	41
KEGG	hsa04064	NF-kappa B signaling pathway	28/668	104/8135	1.025e-08	1.62e-06	1.036e-06	TNFAIP3/CCL13/RELB/LCK/ICAM1/PRKCB/BIRC3/CD40/NFKB2/IL1B/CXCL8/NFKBIA/NFKB1/LY96/TRAF1/CD14/CXCL1/MYD88/PLCG2/ERC1/CXCL3/BCL2A1/LBP/CXCL12/TRAF3/TNFSF14/IKBKG/LAT	28
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	27/668	100/8135	1.761e-08	1.62e-06	1.036e-06	FOXO1/PLCB1/TGFB2/VEGFA/ICAM1/AKT3/PRKCB/IL1B/SMAD3/MAPK3/CXCL8/NFKB1/CCND1/PLCG2/COL1A1/PIM1/CDK4/MAPK10/STAT1/SERPINE1/MAPK13/AGTR1/CCL2/NRAS/COL3A1/COL4A1/JUN	27
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	44/668	222/8135	2.435e-08	1.62e-06	1.036e-06	CREB3L2/CD3D/IL15RA/IL2RG/EGR2/RELB/TGFB2/IL2RB/LCK/ICAM1/AKT3/CD40/NFKB2/SMAD3/ADCY9/MAPK3/CCND2/TLN2/ITGAL/NFKBIA/NFKB1/CCND1/CDKN2C/CD3G/ADCY6/PTTG1/CCNA2/CDK4/ETS2/HLA-DOB/MAPK10/HLA-DMA/SLC25A4/KAT5/HLA-DMB/ITGB2/IL2RA/NRAS/IKBKG/PPP3CC/IL15/JUN/ADCY1/CCNB2	44
KEGG	hsa04659	Th17 cell differentiation	28/668	108/8135	2.529e-08	1.62e-06	1.036e-06	CD247/CD3D/IL4R/NFKBIE/IL2RG/IL2RB/LCK/GATA3/IL1B/SMAD3/MAPK3/IL27RA/NFKBIA/NFKB1/CD3G/HIF1A/HLA-DOB/MAPK10/STAT1/HLA-DMA/MAPK13/HLA-DMB/IL2RA/IKBKG/RXRA/PPP3CC/JUN/LAT	28
KEGG	hsa04060	Cytokine-cytokine receptor interaction	53/668	295/8135	3.028e-08	1.62e-06	1.036e-06	TNFRSF1B/IL4R/CXCR4/IL15RA/CCL5/IL2RG/CXCL13/IFNAR2/IL7R/CCL13/TGFB2/IL2RB/IL32/IL11RA/TNFRSF10B/IL1RN/CD40/IL1B/CCL18/CCR7/CSF2RB/IL27RA/CXCL8/CCR5/TNFSF10/CXCL1/CD27/CX3CR1/CCR2/CXCL6/CXCR6/BMP4/TNFRSF4/CCR6/IL17RA/PF4/CXCL3/TNFRSF17/NGF/CXCL10/GDF10/BMPR1A/CXCL12/TNFSF14/CCL2/IL2RA/IL3RA/LIFR/IL9R/CSF2RA/INHBB/CCL7/IL15	53
KEGG	hsa04658	Th1 and Th2 cell differentiation	25/668	92/8135	5.195e-08	2.382e-06	1.523e-06	CD247/RUNX3/CD3D/IL4R/NFKBIE/IL2RG/IL2RB/LCK/GATA3/MAPK3/NFKBIA/NFKB1/STAT4/CD3G/HLA-DOB/MAPK10/STAT1/HLA-DMA/MAPK13/HLA-DMB/IL2RA/IKBKG/PPP3CC/JUN/LAT	25
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/668	100/8135	7.513e-08	3.014e-06	1.928e-06	TNFRSF1B/CXCR4/CCL5/IL2RG/CXCL13/CCL13/IL2RB/TNFRSF10B/CCL18/CCR7/CXCL8/CCR5/TNFSF10/CXCL1/CX3CR1/CCR2/CXCL6/CCR6/PF4/CXCL3/CXCL10/CXCL12/TNFSF14/CCL2/IL2RA/CCL7	26
KEGG	hsa05169	Epstein-Barr virus infection	40/668	202/8135	1.098e-07	3.918e-06	2.505e-06	CD247/RUNX3/CD3D/TNFAIP3/NFKBIE/IFNAR2/RELB/TAP1/ICAM1/AKT3/CD40/NFKB2/CCND2/ITGAL/NFKBIA/NFKB1/CCND1/CD44/MYD88/PLCG2/CD3G/CCNA2/CDK4/HDAC1/HLA-DOB/MAPK10/TLR2/USP7/STAT1/HLA-DMA/CXCL10/MAPK13/HLA-DMB/IRF7/TAPBP/TRAF3/OAS2/IKBKG/IKBKE/JUN	40
KEGG	hsa04660	T cell receptor signaling pathway	26/668	104/8135	1.765e-07	5.664e-06	3.622e-06	CD247/CD3D/NFKBIE/RASGRP1/ITK/LCK/CD8A/AKT3/PAK1/MAPK3/PTPN6/NFKBIA/NFKB1/PTPRC/LCP2/PAK2/CD3G/CDK4/MAPK10/MAPK13/VAV1/NRAS/IKBKG/PPP3CC/JUN/LAT	26
KEGG	hsa05144	Malaria	17/668	50/8135	2.142e-07	5.996e-06	3.834e-06	HBB/TGFB2/ICAM1/CD40/THBS2/IL1B/SDC1/CXCL8/ITGAL/MYD88/KLRB1/PECAM1/TLR2/THBS4/ITGB2/CCL2/SELP	17
KEGG	hsa05417	Lipid and atherosclerosis	41/668	215/8135	2.241e-07	5.996e-06	3.834e-06	PLCB1/CCL5/TNFRSF10B/ICAM1/AKT3/CD40/IL1B/XBP1/MAPK3/CXCL8/NFKBIA/NFKB1/TNFSF10/HSPA5/LY96/CD14/CXCL1/MYD88/ABCG1/ATF6/BAD/CXCL3/MAPK10/TLR2/OLR1/MAPK13/IRF7/LBP/NLRP3/VAV1/TRAF3/CASP7/NCF2/CCL2/NRAS/IKBKG/RXRA/IKBKE/PPP3CC/SELP/JUN	41
KEGG	hsa05323	Rheumatoid arthritis	24/668	93/8135	2.777e-07	6.858e-06	4.385e-06	CCL5/ANGPT1/TGFB2/VEGFA/ICAM1/IL1B/CXCL8/ITGAL/CTSL/CXCL1/CXCL6/HLA-DOB/CXCL3/TLR2/HLA-DMA/HLA-DMB/CD86/CXCL12/ITGB2/CCL2/ATP6V0D1/FLT1/IL15/JUN	24
KEGG	hsa04662	B cell receptor signaling pathway	22/668	82/8135	4.202e-07	9.635e-06	6.161e-06	NFKBIE/RAC2/LILRB2/AKT3/PRKCB/FCGR2B/LILRA3/MAPK3/LILRB4/PTPN6/NFKBIA/NFKB1/LILRA2/PLCG2/LILRB3/INPP5D/VAV1/NRAS/CD72/IKBKG/PPP3CC/JUN	22
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	23/668	89/8135	4.787e-07	1.024e-05	6.55e-06	CD247/CD3D/NFKBIE/EGFR/RASGRP1/LCK/AKT3/MAPK3/PTPN6/NFKBIA/BATF/NFKB1/MYD88/CD3G/HIF1A/TLR2/STAT1/MAPK13/NRAS/IKBKG/PPP3CC/JUN/LAT	23
KEGG	hsa05140	Leishmaniasis	21/668	77/8135	5.711e-07	1.146e-05	7.326e-06	TGFB2/PRKCB/IL1B/MAPK3/PTPN6/NFKBIA/NFKB1/MYD88/ITGA4/FCGR2A/EEF1A2/HLA-DOB/TLR2/STAT1/HLA-DMA/MAPK13/HLA-DMB/ITGB2/NCF2/JUN/MARCKSL1	21
KEGG	hsa04620	Toll-like receptor signaling pathway	25/668	104/8135	6.79e-07	1.282e-05	8.198e-06	SPP1/CCL5/IFNAR2/AKT3/CD40/IL1B/MAPK3/CXCL8/NFKBIA/NFKB1/LY96/CD14/MYD88/MAPK10/TLR2/STAT1/CXCL10/MAPK13/IRF7/CD86/LBP/TRAF3/IKBKG/IKBKE/JUN	25
KEGG	hsa04380	Osteoclast differentiation	28/668	128/8135	1.158e-06	2.065e-05	1.321e-05	IFNAR2/RELB/TGFB2/LILRB2/LCK/AKT3/FCGR2B/NFKB2/IL1B/LILRA3/MAPK3/LILRB4/GAB2/NFKBIA/NFKB1/LILRA2/LCP2/PLCG2/FCGR2A/MAPK10/STAT1/LILRB3/MAPK13/FOSL2/NCF2/IKBKG/PPP3CC/JUN	28
KEGG	hsa04510	Focal adhesion	37/668	201/8135	2.143e-06	3.621e-05	2.315e-05	SPP1/PARVA/RAC2/ITGB7/VEGFA/ITGAV/EGFR/FLNB/AKT3/PRKCB/BIRC3/THBS2/ACTN1/PAK1/MAPK3/CCND2/DOCK1/TLN2/MYL2/CCND1/ITGA4/MYL9/PAK2/COL1A1/CAV3/RAPGEF1/ITGA5/BAD/MAPK10/THBS4/LAMB2/ARHGAP5/VAV1/PDGFRA/COL4A1/FLT1/JUN	37
KEGG	hsa04668	TNF signaling pathway	25/668	112/8135	2.937e-06	4.713e-05	3.014e-05	CREB3L2/TNFAIP3/TNFRSF1B/CCL5/ICAM1/IRF1/AKT3/BIRC3/IL1B/MAPK3/NFKBIA/NFKB1/TRAF1/CXCL1/CXCL6/CXCL3/MAPK10/CXCL10/MAPK13/TRAF3/CASP7/CCL2/IKBKG/IL15/JUN	25
KEGG	hsa04210	Apoptosis	28/668	136/8135	4.111e-06	6.283e-05	4.018e-05	GZMB/TNFRSF10B/PTPN13/AKT3/BIRC3/DAXX/CSF2RB/CTSD/MAPK3/NFKBIA/NFKB1/CTSC/TNFSF10/TRAF1/CTSL/CTSH/CTSF/PARP3/BAD/MAPK10/BCL2A1/NGF/LMNB1/CASP7/IL3RA/NRAS/IKBKG/JUN	28
KEGG	hsa05162	Measles	28/668	139/8135	6.402e-06	9.341e-05	5.973e-05	CD3D/TNFAIP3/IL2RG/IFNAR2/IL2RB/AKT3/FCGR2B/IL1B/SLAMF1/CCND2/NFKBIA/NFKB1/CCND1/MYD88/CD3G/CDK4/BAD/MX2/MAPK10/TLR2/STAT1/IRF7/TRAF3/IL2RA/OAS2/IKBKG/IKBKE/JUN	28
KEGG	hsa04936	Alcoholic liver disease	28/668	142/8135	9.811e-06	0.0001369	8.756e-05	FOXO1/ADIPOQ/ADH1B/AKT3/TCF7/TCF7L2/IL1B/ADIPOR2/ADH1A/CXCL8/NFKBIA/ADH1C/NFKB1/CCND1/LY96/CD14/CXCL1/MYD88/IL17RA/CXCL3/MAPK10/MAPK13/LBP/TRAF3/C3AR1/ALDH3A2/IKBKG/IKBKE	28
KEGG	hsa04640	Hematopoietic cell lineage	22/668	99/8135	1.24e-05	0.0001658	0.000106	CD3D/IL4R/IL7R/IL11RA/CD8A/IL1B/CD2/CD38/CD44/CD14/ITGA4/CD3G/CD37/ITGA5/HLA-DOB/HLA-DMA/HLA-DMB/TFRC/IL2RA/IL3RA/IL9R/CSF2RA	22
KEGG	hsa04010	MAPK signaling pathway	46/668	294/8135	1.31e-05	0.0001682	0.0001076	RAC2/ANGPT1/RELB/TGFA/TGFB2/VEGFA/EGFR/RASGRP1/DUSP5/FLNB/AKT3/PRKCB/PTPN7/NFKB2/IL1B/PAK1/DAXX/MAPK3/HSPB1/CDC25B/MAP3K4/NFKB1/CD14/MYD88/INSR/PAK2/FGFR1/EFNA5/MAP4K1/MAPK7/NTF3/MAPK10/NGF/DUSP2/MAPK13/DUSP3/PPM1A/ANGPT2/FGFR3/NRAS/GNG12/PDGFRA/IKBKG/PPP3CC/FLT1/JUN	46
KEGG	hsa04657	IL-17 signaling pathway	21/668	94/8135	1.787e-05	0.0002139	0.0001368	TNFAIP3/IL1B/MAPK3/CXCL8/NFKBIA/S100A9/NFKB1/CXCL1/CXCL6/MAPK7/IL17RA/CXCL3/MAPK10/CXCL10/MAPK13/TRAF3/CCL2/IKBKG/IKBKE/CCL7/JUN	21
KEGG	hsa04068	FoxO signaling pathway	26/668	131/8135	1.799e-05	0.0002139	0.0001368	FOXO1/IL7R/TGFB2/EGFR/PCK1/AKT3/SMAD3/S1PR1/MAPK3/CCND2/CCND1/TNFSF10/INSR/GABARAPL1/PLK2/HOMER3/CCNB1/MAPK10/USP7/MAPK13/PLK1/NRAS/BNIP3/S1PR4/PCK2/CCNB2	26
KEGG	hsa05142	Chagas disease	22/668	102/8135	2.046e-05	0.0002346	0.00015	CD247/CD3D/PLCB1/CCL5/TGFB2/AKT3/IL1B/MAPK3/CXCL8/NFKBIA/GNA11/NFKB1/MYD88/CD3G/MAPK10/TLR2/SERPINE1/MAPK13/CCL2/IKBKG/JUN/ADCY1	22
KEGG	hsa05205	Proteoglycans in cancer	35/668	205/8135	2.242e-05	0.0002482	0.0001587	TGFB2/VEGFA/ITGAV/EGFR/ANK3/FLNB/HBEGF/AKT3/PRKCB/HSPB2/PAK1/SDC1/MAPK3/PTPN6/FZD2/CCND1/CD44/CTSL/PLCG2/HCLS1/COL1A1/FGFR1/CAV3/HIF1A/ITGA5/PLAUR/FZD7/TIMP3/TLR2/CTTN/MAPK13/TWIST1/VAV1/TFAP4/NRAS	35
KEGG	hsa05414	Dilated cardiomyopathy	21/668	96/8135	2.51e-05	0.0002685	0.0001717	ITGB7/TPM2/TGFB2/ITGAV/SGCA/DAG1/TPM4/ADCY9/DES/PLN/MYL2/ITGA4/ADCY6/MYH7/TNNC1/MYL3/ITGA5/ATP2A1/TPM3/TTN/ADCY1	21
KEGG	hsa04621	NOD-like receptor signaling pathway	32/668	184/8135	3.443e-05	0.0003566	0.000228	PLCB1/TNFAIP3/CCL5/IFNAR2/AIM2/BIRC3/IL1B/NAMPT/TP53BP1/MAPK3/CXCL8/NFKBIA/NFKB1/CXCL1/MYD88/GABARAPL1/CASP4/GBP2/CXCL3/MAPK10/STAT1/GBP1/MAPK13/IRF7/NLRP3/TRAF3/PSTPIP1/CCL2/OAS2/IKBKG/IKBKE/JUN	32
KEGG	hsa05134	Legionellosis	15/668	57/8135	3.754e-05	0.0003686	0.0002357	NFKB2/IL1B/CXCL8/NFKBIA/NFKB1/CD14/CXCL1/MYD88/CLK1/EEF1A2/CXCL3/TLR2/CASP7/ITGB2/BNIP3	15
KEGG	hsa04015	Rap1 signaling pathway	35/668	210/8135	3.79e-05	0.0003686	0.0002357	PLCB1/MAGI2/SIPA1L1/RAC2/ANGPT1/VEGFA/EGFR/AKT3/PRKCB/ADCY9/MAPK3/TLN2/ITGAL/RALA/LCP2/INSR/ID1/ADCY6/FGFR1/SKAP1/RAPGEF1/F2R/EFNA5/NGF/MAPK13/VAV1/ITGB2/ANGPT2/FGFR3/NRAS/PDGFRA/PFN2/FLT1/ADCY1/LAT	35
KEGG	hsa04670	Leukocyte transendothelial migration	23/668	114/8135	4.142e-05	0.0003911	0.0002501	CXCR4/RAC2/RHOH/ITK/ICAM1/PRKCB/PTK2B/CLDN7/ACTN1/ITGAL/MYL2/CDH5/ITGA4/MYL9/PLCG2/THY1/PECAM1/MAPK13/CXCL12/ARHGAP5/VAV1/ITGB2/NCF2	23
KEGG	hsa04810	Regulation of actin cytoskeleton	35/668	218/8135	8.361e-05	0.0007668	0.0004904	CXCR4/RAC2/ITGB7/GSN/ITGAV/EGFR/PIP4K2B/ITGAX/ACTN1/PAK1/MAPK3/DOCK1/ITGAL/MYL2/MYH11/MYH10/ITGA4/MYL9/PAK2/FGFR1/F2R/ITGA5/NCKAP1/NCKAP1L/ARPC3/CXCL12/VAV1/ITGB2/FGFR3/NRAS/GNG12/PDGFRA/PFN2/CYFIP2/CHRM3	35
KEGG	hsa04625	C-type lectin receptor signaling pathway	21/668	104/8135	8.751e-05	0.0007803	0.000499	EGR2/RELB/IRF1/AKT3/NFKB2/IL1B/PAK1/MAPK3/NFKBIA/NFKB1/PLCG2/EGR3/MAPK10/STAT1/MAPK13/NLRP3/NRAS/IKBKG/IKBKE/PPP3CC/JUN	21
KEGG	hsa00350	Tyrosine metabolism	11/668	36/8135	9.403e-05	0.0008157	0.0005216	MAOA/ADH1B/AOC3/FAH/ADH1A/ADH1C/GOT2/HPD/PNMT/ALDH3B1/GOT1	11
KEGG	hsa05133	Pertussis	17/668	76/8135	0.0001093	0.0009122	0.0005833	IRF1/IL1B/MAPK3/CXCL8/NFKB1/LY96/CD14/MYD88/CXCL6/IRF8/ITGA5/MAPK10/MAPK13/NLRP3/CASP7/ITGB2/JUN	17
KEGG	hsa05135	Yersinia infection	25/668	137/8135	0.0001108	0.0009122	0.0005833	RAC2/LCK/CD8A/AKT3/PTK2B/IL1B/MAPK3/DOCK1/CXCL8/NFKBIA/NFKB1/MYD88/LCP2/ITGA4/ITGA5/FCGR2A/MAPK10/ARPC3/MAPK13/NLRP3/VAV1/CCL2/IKBKG/JUN/LAT	25
KEGG	hsa05164	Influenza A	29/668	171/8135	0.0001265	0.001015	0.000649	CCL5/IFNAR2/TNFRSF10B/ICAM1/AKT3/PRKCB/IL1B/MAPK3/CXCL8/NFKBIA/NFKB1/TNFSF10/MYD88/CDK4/MX2/HLA-DOB/STAT1/HLA-DMA/CXCL10/SLC25A4/HLA-DMB/IRF7/NLRP3/TRAF3/NXF1/CCL2/OAS2/IKBKG/IKBKE	29
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/668	70/8135	0.0001321	0.001034	0.0006613	CCL5/EGFR/HBEGF/PAK1/CXCL8/NFKBIA/NFKB1/CXCL1/PLCG2/CXCL3/MAPK10/MAPK13/CSK/IKBKG/ATP6V0D1/JUN	16
KEGG	hsa05171	Coronavirus disease - COVID-19	36/668	232/8135	0.0001358	0.001035	0.0006621	IFNAR2/EGFR/CFB/HBEGF/PRKCB/IL1B/MAPK3/CXCL8/NFKBIA/NFKB1/MYD88/PLCG2/RPS5/CFD/FCGR2A/RPL18/MX2/MAPK10/TLR2/STAT1/CXCL10/RPLP0/MAPK13/C6/NLRP3/AGTR1/TRAF3/C7/C3AR1/CCL2/RPL13/OAS2/IKBKG/IKBKE/SELP/JUN	36
KEGG	hsa05418	Fluid shear stress and atherosclerosis	25/668	139/8135	0.000141	0.001035	0.0006621	RAC2/VEGFA/ITGAV/ICAM1/AKT3/IL1B/SDC1/ASS1/NFKB1/CDH5/CTSL/CAV3/BMP4/GSTA4/PECAM1/NQO1/MAPK7/MAPK10/BMPR1A/MAPK13/GSTT1/NCF2/CCL2/IKBKG/JUN	25
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	24/668	131/8135	0.0001419	0.001035	0.0006621	CD247/RAC2/IFNAR2/GZMB/TNFRSF10B/LCK/ICAM1/PRKCB/PTK2B/CD48/SH2D1A/PAK1/MAPK3/PTPN6/ITGAL/TNFSF10/LCP2/PLCG2/VAV1/ITGB2/NRAS/KLRD1/PPP3CC/LAT	24
KEGG	hsa05340	Primary immunodeficiency	11/668	38/8135	0.0001618	0.001154	0.000738	CD3D/IL2RG/IL7R/LCK/TAP1/ADA/CD8A/CD40/PTPRC/RFX5/IKBKG	11
KEGG	hsa04151	PI3K-Akt signaling pathway	49/668	354/8135	0.0001745	0.001218	0.0007786	CREB3L2/SPP1/IL4R/MAGI2/ITGB7/IL2RG/IFNAR2/ANGPT1/IL7R/TGFA/IL2RB/VEGFA/ITGAV/EGFR/PHLPP1/PCK1/AKT3/THBS2/MAPK3/CCND2/NFKB1/CCND1/ITGA4/INSR/COL1A1/FGFR1/F2R/ITGA5/EFNA5/CDK4/NTF3/BAD/TLR2/NGF/DDIT4/THBS4/LAMB2/ANGPT2/FGFR3/IL2RA/IL3RA/NRAS/GNG12/PDGFRA/IKBKG/RXRA/COL4A1/PCK2/FLT1	49
KEGG	hsa05170	Human immunodeficiency virus 1 infection	33/668	212/8135	0.0002411	0.001647	0.001053	CD247/CD3D/TNFRSF1B/CXCR4/RAC2/TAP1/AKT3/PRKCB/PTK2B/PAK1/MAPK3/NFKBIA/GNA11/NFKB1/CCR5/MYD88/PLCG2/PAK2/CD3G/AP1B1/CCNB1/BAD/MAPK10/TLR2/MAPK13/TAPBP/NRAS/GNG12/CUL4A/IKBKG/PPP3CC/JUN/CCNB2	33
KEGG	hsa05145	Toxoplasmosis	21/668	112/8135	0.0002617	0.00175	0.001119	TGFB2/AKT3/BIRC3/CD40/MAPK3/NFKBIA/NFKB1/CCR5/LY96/MYD88/BAD/HLA-DOB/MAPK10/TLR2/STAT1/HLA-DMA/MAPK13/HLA-DMB/LAMB2/IKBKG/ALOX5	21
KEGG	hsa05221	Acute myeloid leukemia	15/668	67/8135	0.0002716	0.001779	0.001138	ZBTB16/AKT3/TCF7/TCF7L2/MAPK3/NFKB1/CCND1/CD14/CCNA2/PIM1/BAD/BCL2A1/PIM2/NRAS/IKBKG	15
KEGG	hsa04919	Thyroid hormone signaling pathway	22/668	121/8135	0.0002974	0.001909	0.001221	FOXO1/PLCB1/ITGAV/THRA/AKT3/PRKCB/PFKM/MAPK3/PLN/CCND1/PLCG2/MYH7/HIF1A/BMP4/ATP2A1/DIO3/HDAC1/BAD/TBC1D4/STAT1/NRAS/RXRA	22
KEGG	hsa05163	Human cytomegalovirus infection	34/668	225/8135	0.0003451	0.002172	0.001389	CREB3L2/PLCB1/CXCR4/CCL5/RAC2/VEGFA/ITGAV/EGFR/TAP1/AKT3/PRKCB/PTK2B/IL1B/ADCY9/MAPK3/CXCL8/NFKBIA/GNA11/NFKB1/CCR5/CCND1/ADCY6/CDK4/MAPK13/CXCL12/TAPBP/PTGER2/CCL2/NRAS/GNG12/PDGFRA/IKBKG/PPP3CC/ADCY1	34
KEGG	hsa05212	Pancreatic cancer	16/668	76/8135	0.0003625	0.002238	0.001431	RAC2/TGFA/TGFB2/VEGFA/EGFR/AKT3/SMAD3/MAPK3/NFKB1/CCND1/RALA/CDK4/BAD/MAPK10/STAT1/IKBKG	16
KEGG	hsa04672	Intestinal immune network for IgA production	12/668	49/8135	0.0004609	0.002791	0.001785	CXCR4/IL15RA/ITGB7/CD40/ITGA4/HLA-DOB/TNFRSF17/HLA-DMA/HLA-DMB/CD86/CXCL12/IL15	12
KEGG	hsa05131	Shigellosis	36/668	247/8135	0.0004743	0.00282	0.001803	FOXO1/PLCB1/CCL5/EGFR/FNBP1L/AKT3/IL1B/ACTN1/HK2/MAPK3/DOCK1/TLN2/CXCL8/NFKBIA/MYL2/NFKB1/CD44/CD14/MYD88/MYL9/PLCG2/HCLS1/CASP4/ITGA5/MAPK10/CAPNS1/FNBP1/CTTN/ARPC3/MAPK13/NLRP3/BNIP3/PFN2/IKBKG/JUN/GLMN	36
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	30/668	194/8135	0.0005116	0.002986	0.001909	IFNAR2/VEGFA/ICAM1/AKT3/TCF7/TCF7L2/MAPK3/CXCL8/NFKBIA/NFKB1/CCR5/CCND1/CXCL1/PLCG2/HIF1A/CDK4/CXCL3/MAPK10/STAT1/MAPK13/IRF7/CD86/TRAF3/ANGPT2/NRAS/GNG12/IKBKG/IKBKE/PPP3CC/JUN	30
KEGG	hsa05146	Amoebiasis	19/668	102/8135	0.0005519	0.003118	0.001994	PLCB1/TGFB2/PRKCB/IL1B/ACTN1/HSPB1/CXCL8/GNA11/NFKB1/CD14/CXCL1/COL1A1/CXCL3/TLR2/LAMB2/ITGB2/COL3A1/COL4A1/ADCY1	19
KEGG	hsa05132	Salmonella infection	36/668	249/8135	0.0005537	0.003118	0.001994	RHOH/TNFRSF10B/FLNB/AKT3/BIRC3/TCF7/TCF7L2/DCTN3/IL1B/PAK1/MAPK3/CXCL8/NFKBIA/MYL2/NFKB1/TNFSF10/RALA/PTPRC/LY96/CD14/MYD88/MYL9/CASP4/NCKAP1/NCKAP1L/MAPK10/TLR2/ARPC3/MAPK13/NLRP3/CASP7/DCTN2/PFN2/IKBKG/CYFIP2/JUN	36
KEGG	hsa05321	Inflammatory bowel disease	14/668	65/8135	0.0006544	0.003533	0.002259	IL4R/IL2RG/TGFB2/GATA3/IL1B/SMAD3/NFKB1/STAT4/HLA-DOB/TLR2/STAT1/HLA-DMA/HLA-DMB/JUN	14
KEGG	hsa05130	Pathogenic Escherichia coli infection	30/668	197/8135	0.0006646	0.003533	0.002259	TNFRSF10B/CLDN7/IL1B/PAK1/MAPK3/PTPN6/CXCL8/NFKBIA/NFKB1/MYH11/TNFSF10/MYH10/MYD88/PAK2/HCLS1/CASP4/F2R/FCGR2A/MYO1B/NCKAP1/NCKAP1L/MAPK10/CTTN/ARPC3/MAPK13/NLRP3/CASP7/IKBKG/CYFIP2/JUN	30
KEGG	hsa04630	JAK-STAT signaling pathway	26/668	162/8135	0.0006714	0.003533	0.002259	IL4R/IL15RA/IL2RG/IFNAR2/IL7R/IL2RB/IL11RA/EGFR/AKT3/CSF2RB/CCND2/PTPN6/IL27RA/STAT4/CCND1/PIM1/STAT1/PTPN2/IL2RA/IL3RA/PDGFRA/FHL1/LIFR/IL9R/CSF2RA/IL15	26
KEGG	hsa05161	Hepatitis B	26/668	162/8135	0.0006714	0.003533	0.002259	CREB3L2/EGR2/TGFB2/AKT3/PRKCB/PTK2B/SMAD3/MAPK3/CXCL8/NFKBIA/NFKB1/STAT4/MYD88/EGR3/CCNA2/BAD/MAPK10/TLR2/STAT1/MAPK13/IRF7/TRAF3/NRAS/IKBKG/IKBKE/JUN	26
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	18/668	97/8135	0.0008021	0.004153	0.002655	RAC2/GSN/AKT3/PRKCB/BIN1/FCGR2B/PAK1/MAPK3/DOCK1/GAB2/PTPRC/PLCG2/FCGR2A/ARPC3/INPP5D/VAV1/MARCKSL1/LAT	18
KEGG	hsa05410	Hypertrophic cardiomyopathy	17/668	90/8135	0.0009024	0.004598	0.00294	ITGB7/TPM2/TGFB2/ITGAV/SGCA/DAG1/TPM4/DES/MYL2/ITGA4/MYH7/TNNC1/MYL3/ITGA5/ATP2A1/TPM3/TTN	17
KEGG	hsa05416	Viral myocarditis	13/668	60/8135	0.0009531	0.00478	0.003057	RAC2/ICAM1/SGCA/CD40/DAG1/ITGAL/CCND1/MYH7/HLA-DOB/HLA-DMA/HLA-DMB/CD86/ITGB2	13
KEGG	hsa04514	Cell adhesion molecules	24/668	149/8135	0.001012	0.004999	0.003196	ITGB7/ITGAV/ICAM1/CD226/CD8A/CD40/CLDN7/CD2/SDC1/SELPLG/ITGAL/PTPRC/CDH5/ITGA4/PECAM1/SELL/HLA-DOB/HLA-DMA/HLA-DMB/CD86/PTPRF/CDH2/ITGB2/SELP	24
KEGG	hsa04664	Fc epsilon RI signaling pathway	14/668	68/8135	0.001051	0.00511	0.003267	RAC2/MS4A2/AKT3/MAPK3/GAB2/LCP2/PLCG2/MAPK10/MAPK13/INPP5D/VAV1/NRAS/ALOX5/LAT	14
KEGG	hsa00360	Phenylalanine metabolism	6/668	16/8135	0.001172	0.005616	0.003591	MAOA/AOC3/GOT2/HPD/ALDH3B1/GOT1	6
KEGG	hsa05219	Bladder cancer	10/668	41/8135	0.001404	0.006628	0.004238	VEGFA/EGFR/HBEGF/MAPK3/CXCL8/CCND1/CDK4/FGFR3/NRAS/TYMP	10
KEGG	hsa05215	Prostate cancer	17/668	97/8135	0.002125	0.009885	0.006321	CREB3L2/FOXO1/TGFA/EGFR/AKT3/TCF7/TCF7L2/MAPK3/NFKBIA/NFKB1/CCND1/AR/FGFR1/BAD/NRAS/PDGFRA/IKBKG	17
KEGG	hsa04014	Ras signaling pathway	32/668	232/8135	0.002408	0.01104	0.007061	RAC2/ANGPT1/TGFA/VEGFA/EGFR/RASGRP1/AKT3/PRKCB/PAK1/MAPK3/GAB2/NFKB1/RALA/INSR/PLCG2/PAK2/FGFR1/EFNA5/ETS2/NTF3/BAD/MAPK10/NGF/RGL1/ANGPT2/FGFR3/NRAS/GNG12/PDGFRA/IKBKG/FLT1/LAT	32
KEGG	hsa04370	VEGF signaling pathway	12/668	59/8135	0.002619	0.01184	0.007572	RAC2/VEGFA/AKT3/PRKCB/SH2D2A/MAPK3/HSPB1/PLCG2/BAD/MAPK13/NRAS/PPP3CC	12
KEGG	hsa04912	GnRH signaling pathway	16/668	93/8135	0.003439	0.01533	0.009805	PLCB1/EGFR/HBEGF/PRKCB/PTK2B/ADCY9/MAPK3/MAP3K4/GNA11/ADCY6/MAPK7/MAPK10/MAPK13/NRAS/JUN/ADCY1	16
KEGG	hsa04722	Neurotrophin signaling pathway	19/668	119/8135	0.003617	0.0159	0.01017	NFKBIE/SH2B2/AKT3/NTRK3/MAPK3/NFKBIA/NFKB1/MAGED1/PLCG2/ARHGDIB/RAPGEF1/MAPK7/NTF3/BAD/MAPK10/NGF/MAPK13/NRAS/JUN	19
KEGG	hsa05210	Colorectal cancer	15/668	86/8135	0.003976	0.01725	0.01103	RAC2/TGFA/TGFB2/EGFR/AKT3/TCF7/TCF7L2/SMAD3/MAPK3/CCND1/RALA/BAD/MAPK10/NRAS/JUN	15
KEGG	hsa04926	Relaxin signaling pathway	20/668	129/8135	0.004065	0.0174	0.01112	CREB3L2/PLCB1/VEGFA/EGFR/AKT3/ADCY9/MAPK3/NFKBIA/NFKB1/COL1A1/ADCY6/ACTA2/MAPK10/MAPK13/NRAS/GNG12/COL3A1/COL4A1/JUN/ADCY1	20
KEGG	hsa05202	Transcriptional misregulation in cancer	27/668	193/8135	0.004186	0.01768	0.0113	FOXO1/ZBTB16/ITGB7/HOXA10/GZMB/IL2RB/CDK14/SIX1/BIRC3/CD40/NUPR1/TSPAN7/CCND2/CXCL8/NFKB1/CDKN2C/TRAF1/CD14/SMAD1/CCNA2/HDAC1/BCL2A1/CD86/HOXA11/RXRA/ELANE/FLT1	27
KEGG	hsa01522	Endocrine resistance	16/668	98/8135	0.005834	0.02432	0.01555	EGFR/HBEGF/AKT3/ADCY9/MAPK3/CCND1/CDKN2C/ADCY6/CDK4/BAD/MAPK10/MAPK13/CARM1/NRAS/JUN/ADCY1	16
KEGG	hsa05152	Tuberculosis	25/668	180/8135	0.006289	0.02588	0.01655	CORO1A/TGFB2/AKT3/ITGAX/FCGR2B/IL1B/CTSD/MAPK3/NFKB1/CD14/MYD88/RFX5/FCGR2A/BAD/HLA-DOB/MAPK10/TLR2/STAT1/HLA-DMA/MAPK13/HLA-DMB/LBP/ITGB2/PPP3CC/ATP6V0D1	25
KEGG	hsa04931	Insulin resistance	17/668	108/8135	0.006644	0.027	0.01726	CREB3L2/FOXO1/PPP1R3C/PCK1/AKT3/PRKCB/NFKBIA/PYGM/NFKB1/PYGB/GFPT1/INSR/SLC27A2/MAPK10/TBC1D4/PTPRF/PCK2	17
KEGG	hsa04066	HIF-1 signaling pathway	17/668	109/8135	0.00729	0.02925	0.01871	ANGPT1/VEGFA/EGFR/AKT3/PRKCB/PFKM/HK2/MAPK3/NFKB1/INSR/PLCG2/HIF1A/SERPINE1/TFRC/ANGPT2/ALDOA/FLT1	17
KEGG	hsa05220	Chronic myeloid leukemia	13/668	76/8135	0.008364	0.03315	0.0212	TGFB2/AKT3/SMAD3/MAPK3/GAB2/NFKBIA/NFKB1/CCND1/CDK4/HDAC1/BAD/NRAS/IKBKG	13
KEGG	hsa05203	Viral carcinogenesis	27/668	204/8135	0.008807	0.03349	0.02141	CREB3L2/EGR2/GSN/NFKB2/ACTN1/MAPK3/CCND2/NFKBIA/NFKB1/CCR5/CCND1/TRAF1/EGR3/CCNA2/CDK4/HDAC1/BAD/MRPS18B/SND1/USP7/HDAC4/IRF7/TRAF3/NRAS/IKBKG/ATP6V0D1/JUN	27
KEGG	hsa01232	Nucleotide metabolism	14/668	85/8135	0.008868	0.03349	0.02141	ENPP1/ADA/HDDC2/AMPD3/HPRT1/DCK/AK1/NME3/GUK1/IMPDH1/IMPDH2/TYMP/TK2/ASMTL	14
KEGG	hsa04012	ErbB signaling pathway	14/668	85/8135	0.008868	0.03349	0.02141	TGFA/EGFR/HBEGF/AKT3/PRKCB/PAK1/MAPK3/BTC/PLCG2/PAK2/BAD/MAPK10/NRAS/JUN	14
KEGG	hsa04610	Complement and coagulation cascades	14/668	85/8135	0.008868	0.03349	0.02141	CFB/SERPINA1/ITGAX/CFD/TFPI/F2R/PLAUR/CFI/F8/SERPINE1/C6/C7/ITGB2/C3AR1	14
KEGG	hsa04920	Adipocytokine signaling pathway	12/668	69/8135	0.009713	0.03584	0.02292	TNFRSF1B/NFKBIE/ADIPOQ/PCK1/AKT3/ADIPOR2/NFKBIA/NFKB1/MAPK10/IKBKG/RXRA/PCK2	12
KEGG	hsa05211	Renal cell carcinoma	12/668	69/8135	0.009713	0.03584	0.02292	TGFA/TGFB2/VEGFA/AKT3/PAK1/MAPK3/PAK2/RAPGEF1/HIF1A/BAD/NRAS/JUN	12
KEGG	hsa05230	Central carbon metabolism in cancer	12/668	70/8135	0.01088	0.03967	0.02537	EGFR/AKT3/NTRK3/PFKM/HK2/MAPK3/SLC7A5/FGFR1/HIF1A/FGFR3/NRAS/PDGFRA	12
KEGG	hsa05150	Staphylococcus aureus infection	15/668	96/8135	0.01114	0.04018	0.02569	CFB/ICAM1/FCGR2B/SELPLG/ITGAL/PTAFR/CFD/FCGR2A/CFI/HLA-DOB/HLA-DMA/HLA-DMB/ITGB2/C3AR1/SELP	15
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/668	79/8135	0.01153	0.04112	0.02629	TGFA/VEGFA/EGFR/AXL/AKT3/PRKCB/MAPK3/PLCG2/GAS6/BAD/FGFR3/NRAS/PDGFRA	13
KEGG	hsa04512	ECM-receptor interaction	14/668	88/8135	0.01196	0.04219	0.02698	SPP1/SV2B/ITGB7/ITGAV/THBS2/DAG1/SDC1/CD44/ITGA4/COL1A1/ITGA5/THBS4/LAMB2/COL4A1	14
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	16/668	106/8135	0.01232	0.04298	0.02748	CREB3L2/PLCB1/EGFR/HBEGF/GATA3/PRKCB/ADCY9/MAPK3/GNA11/PTHLH/ADCY6/FGFR1/LRP5/RXRA/MMP15/ADCY1	16
KEGG	hsa04623	Cytosolic DNA-sensing pathway	11/668	63/8135	0.01264	0.04332	0.0277	CCL5/AIM2/IL1B/NFKBIA/NFKB1/POLR2E/CXCL10/IRF7/POLR1C/IKBKG/IKBKE	11
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/668	143/8135	0.01269	0.04332	0.0277	AKT3/PCGF2/TCF7/SMAD3/MAPK3/FZD2/ID3/SMAD1/ID1/FGFR1/ID4/BMP4/FZD7/BMPR1A/MAPK13/JARID2/FGFR3/NRAS/LIFR/INHBB	20
KEGG	hsa04020	Calcium signaling pathway	30/668	240/8135	0.01308	0.04419	0.02826	PLCB1/CXCR4/VEGFA/PDE1A/EGFR/NTRK3/PRKCB/PTK2B/ADCY9/PLN/GNA11/PTAFR/CD38/CASQ2/TNNC2/ASPH/PLCG2/FGFR1/TNNC1/F2R/ATP2A1/NGF/SLC25A4/AGTR1/FGFR3/PDGFRA/PPP3CC/CHRM3/FLT1/ADCY1	30
KEGG	hsa05165	Human papillomavirus infection	39/668	331/8135	0.01325	0.04431	0.02833	CREB3L2/SPP1/FOXO1/ITGB7/IFNAR2/VEGFA/ITGAV/EGFR/IRF1/AKT3/THBS2/TCF7/TCF7L2/MAPK3/CCND2/FZD2/NFKB1/CCND1/ITGA4/COL1A1/CCNA2/ITGA5/CDK4/FZD7/LFNG/NFX1/HDAC1/BAD/MX2/TADA3/STAT1/THBS4/LAMB2/TRAF3/NRAS/IKBKG/IKBKE/ATP6V0D1/COL4A1	39
KEGG	hsa04923	Regulation of lipolysis in adipocytes	10/668	56/8135	0.01463	0.04842	0.03096	FABP4/PTGS1/PLIN1/AKT3/ADCY9/ADORA1/INSR/ADCY6/PRKG1/ADCY1	10
KEGG	hsa05415	Diabetic cardiomyopathy	26/668	203/8135	0.01499	0.0491	0.0314	PLCB1/RAC2/TGFB2/AKT3/PRKCB/SMAD3/CTSD/PLN/NFKB1/PDK2/COX7A1/GFPT1/INSR/COL1A1/ATP2A1/COX6A2/MAPK10/TBC1D4/SLC25A4/MAPK13/AGTR1/NDUFB7/NDUFV1/NCF2/COL3A1/UQCRC1	26
KEGG	hsa00790	Folate biosynthesis	6/668	26/8135	0.01664	0.05395	0.0345	AKR1B1/GCH1/ALPL/PCBD1/AKR1B10/QDPR	6
KEGG	hsa05222	Small cell lung cancer	14/668	92/8135	0.01732	0.05559	0.03555	ITGAV/AKT3/BIRC3/NFKBIA/NFKB1/CKS1B/CCND1/TRAF1/CDK4/LAMB2/TRAF3/IKBKG/RXRA/COL4A1	14
KEGG	hsa04022	cGMP-PKG signaling pathway	22/668	167/8135	0.01785	0.05674	0.03628	CREB3L2/PLCB1/AKT3/ADCY9/MAPK3/ADORA3/ADORA1/PLN/GNA11/RGS2/KCNJ8/MYL9/INSR/ADCY6/MYH7/ATP2A1/BAD/PRKG1/SLC25A4/AGTR1/PPP3CC/ADCY1	22
KEGG	hsa04072	Phospholipase D signaling pathway	20/668	148/8135	0.01803	0.05675	0.03629	PLCB1/EGFR/MS4A2/AKT3/PTK2B/ADCY9/MAPK3/GAB2/CXCL8/RALA/INSR/PLCG2/DNM1/ADCY6/F2R/AGTR1/AGPAT1/NRAS/PDGFRA/ADCY1	20
KEGG	hsa00010	Glycolysis / Gluconeogenesis	11/668	67/8135	0.0196	0.06108	0.03906	ADH1B/PCK1/PFKM/HK2/ADH1A/ADH1C/ALDH3B1/MINPP1/ALDH3A2/ALDOA/PCK2	11
KEGG	hsa00071	Fatty acid degradation	8/668	43/8135	0.02195	0.06776	0.04333	ADH1B/ECI1/ADH1A/ECHS1/ADH1C/ACADS/HADH/ALDH3A2	8
KEGG	hsa04611	Platelet activation	17/668	124/8135	0.02451	0.07423	0.04747	PLCB1/PTGS1/RASGRP1/AKT3/ADCY9/MAPK3/TLN2/LCP2/PLCG2/COL1A1/ADCY6/F2R/FCGR2A/PRKG1/MAPK13/COL3A1/ADCY1	17
KEGG	hsa04260	Cardiac muscle contraction	13/668	87/8135	0.02451	0.07423	0.04747	TPM2/TPM4/MYL2/CASQ2/COX7A1/ASPH/MYH7/TNNC1/MYL3/ATP2A1/TPM3/COX6A2/UQCRC1	13
KEGG	hsa04622	RIG-I-like receptor signaling pathway	11/668	70/8135	0.02643	0.0793	0.05071	CXCL8/NFKBIA/NFKB1/PIN1/MAPK10/CXCL10/MAPK13/IRF7/TRAF3/IKBKG/IKBKE	11
KEGG	hsa05216	Thyroid cancer	7/668	37/8135	0.02869	0.08527	0.05452	TCF7/TCF7L2/MAPK3/CCND1/TPM3/NRAS/RXRA	7
KEGG	hsa04520	Adherens junction	11/668	71/8135	0.02905	0.08556	0.05471	RAC2/EGFR/TCF7/TCF7L2/ACTN1/SMAD3/MAPK3/PTPN6/INSR/FGFR1/PTPRF	11
KEGG	hsa00340	Histidine metabolism	5/668	22/8135	0.02994	0.08737	0.05587	MAOA/HDC/ALDH3B1/ASPA/ALDH3A2	5
KEGG	hsa05223	Non-small cell lung cancer	11/668	72/8135	0.03185	0.09144	0.05847	TGFA/EGFR/AKT3/PRKCB/MAPK3/CCND1/PLCG2/CDK4/BAD/NRAS/RXRA	11
KEGG	hsa05160	Hepatitis C	20/668	157/8135	0.0319	0.09144	0.05847	IFNAR2/EGFR/AKT3/CLDN7/MAPK3/NFKBIA/NFKB1/CCND1/CDK4/BAD/MX2/STAT1/CXCL10/IRF7/TRAF3/NRAS/OAS2/IKBKG/RXRA/IKBKE	20
KEGG	hsa00230	Purine metabolism	17/668	128/8135	0.03222	0.09152	0.05852	PDE1A/ENPP1/ADA/ADCY9/HDDC2/AMPD3/HPRT1/ADCY6/DCK/PAPSS2/AK1/PDE9A/NME3/GUK1/IMPDH1/IMPDH2/ADCY1	17
KEGG	hsa04071	Sphingolipid signaling pathway	16/668	119/8135	0.03349	0.09431	0.06031	PLCB1/RAC2/MS4A2/AKT3/PRKCB/S1PR1/CTSD/MAPK3/ADORA3/ADORA1/GAB2/NFKB1/MAPK10/MAPK13/NRAS/S1PR4	16
KEGG	hsa05225	Hepatocellular carcinoma	21/668	168/8135	0.03406	0.09507	0.06079	TGFA/TGFB2/EGFR/AKT3/PRKCB/TCF7/TCF7L2/SMAD3/MAPK3/FZD2/CCND1/PLCG2/SMARCD3/GSTA4/NQO1/CDK4/FZD7/LRP5/BAD/GSTT1/NRAS	21
KEGG	hsa04371	Apelin signaling pathway	18/668	139/8135	0.03507	0.09704	0.06205	SPP1/PLCB1/PLIN1/AKT3/SMAD3/ADCY9/MAPK3/MYL2/CCND1/ADCY6/MYL3/ACTA2/SERPINE1/HDAC4/AGTR1/NRAS/GNG12/ADCY1	18
KEGG	hsa00620	Pyruvate metabolism	8/668	47/8135	0.03573	0.09803	0.06268	ADH1B/GRHPR/PCK1/ADH1A/ADH1C/PC/ALDH3A2/PCK2	8
KEGG	hsa00410	beta-Alanine metabolism	6/668	31/8135	0.03758	0.1017	0.06504	ALDH6A1/AOC3/ECHS1/ACADS/ALDH3B1/ALDH3A2	6
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	19/668	150/8135	0.03771	0.1017	0.06504	CREB3L2/PLCB1/TPM2/AKT3/TPM4/ADCY9/MAPK3/PLN/MYL2/ADCY6/MYH7/TNNC1/MYL3/ATP2A1/TPM3/PPP1R1A/MAPK13/AGTR1/ADCY1	19
KEGG	hsa00280	Valine, leucine and isoleucine degradation	8/668	48/8135	0.03992	0.1068	0.06828	ALDH6A1/ECHS1/ACADS/HADH/OXCT1/BCAT1/BCKDHA/ALDH3A2	8
KEGG	hsa03320	PPAR signaling pathway	11/668	75/8135	0.0414	0.1098	0.07023	LPL/FABP4/ADIPOQ/PCK1/PLIN1/GK/SLC27A2/ACOX2/OLR1/RXRA/PCK2	11
KEGG	hsa04360	Axon guidance	22/668	182/8135	0.04226	0.1105	0.07064	CXCR4/RAC2/SEMA5A/EPHA3/SEMA3E/SEMA3A/PAK1/MAPK3/ABLIM1/MYL9/PLCG2/PAK2/SEMA3C/UNC5C/SEMA4F/EFNA5/PLXNC1/PLXNA2/CXCL12/NRAS/DPYSL2/PPP3CC	22
KEGG	hsa04145	Phagosome	19/668	152/8135	0.04233	0.1105	0.07064	CORO1A/ITGAV/TAP1/THBS2/FCGR2B/CD14/CTSL/ITGA5/FCGR2A/HLA-DOB/TLR2/OLR1/HLA-DMA/HLA-DMB/THBS4/TFRC/ITGB2/NCF2/ATP6V0D1	19
KEGG	hsa00920	Sulfur metabolism	3/668	10/8135	0.04274	0.1106	0.07075	SELENBP1/PAPSS2/TST	3
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/668	77/8135	0.04876	0.1252	0.08007	ITGB7/ITGAV/SGCA/DAG1/TCF7/TCF7L2/DES/ITGA4/ITGA5/ATP2A1/CDH2	11
KEGG	hsa00051	Fructose and mannose metabolism	6/668	33/8135	0.04925	0.1255	0.08022	AKR1B1/PFKM/HK2/MPI/AKR1B10/ALDOA	6
KEGG	hsa04612	Antigen processing and presentation	11/668	78/8135	0.05276	0.1316	0.08413	TAP1/CD8A/HSPA5/CTSL/RFX5/HLA-DOB/HLA-DMA/HLA-DMB/TAPBP/LGMN/KLRD1	11
KEGG	hsa04218	Cellular senescence	19/668	156/8135	0.05278	0.1316	0.08413	FOXO1/TGFB2/AKT3/SMAD3/MAPK3/CCND2/CXCL8/NFKB1/CCND1/CCNA2/CDK4/CCNB1/SERPINE1/SLC25A4/MAPK13/LIN37/NRAS/PPP3CC/CCNB2	19
KEGG	hsa05332	Graft-versus-host disease	7/668	42/8135	0.05287	0.1316	0.08413	GZMB/IL1B/HLA-DOB/HLA-DMA/HLA-DMB/CD86/KLRD1	7
KEGG	hsa00270	Cysteine and methionine metabolism	8/668	51/8135	0.0544	0.1343	0.0859	GOT2/BCAT1/CDO1/GOT1/AHCY/TST/SDS/AHCYL2	8
KEGG	hsa04540	Gap junction	12/668	88/8135	0.05507	0.135	0.0863	PLCB1/EGFR/PRKCB/ADCY9/MAPK3/GNA11/ADCY6/MAPK7/PRKG1/NRAS/PDGFRA/ADCY1	12
KEGG	hsa04917	Prolactin signaling pathway	10/668	70/8135	0.05854	0.1417	0.09059	IRF1/AKT3/MAPK3/CCND2/NFKB1/CCND1/MAPK10/STAT1/MAPK13/NRAS	10
KEGG	hsa04940	Type I diabetes mellitus	7/668	43/8135	0.05888	0.1417	0.09059	GZMB/IL1B/ICA1/HLA-DOB/HLA-DMA/HLA-DMB/CD86	7
KEGG	hsa04211	Longevity regulating pathway	12/668	89/8135	0.05914	0.1417	0.09059	CREB3L2/FOXO1/ADIPOQ/AKT3/ADIPOR2/ADCY9/NFKB1/INSR/ADCY6/EHMT2/NRAS/ADCY1	12
KEGG	hsa04213	Longevity regulating pathway - multiple species	9/668	62/8135	0.06491	0.1543	0.0987	FOXO1/CRYAB/AKT3/ADCY9/INSR/ADCY6/HDAC1/NRAS/ADCY1	9
KEGG	hsa04914	Progesterone-mediated oocyte maturation	13/668	102/8135	0.07346	0.1734	0.1109	AKT3/ADCY9/MAPK3/CDC25B/ADCY6/STK10/CCNA2/CCNB1/MAPK10/MAPK13/PLK1/ADCY1/CCNB2	13
KEGG	hsa00650	Butanoate metabolism	5/668	28/8135	0.07469	0.175	0.1119	ECHS1/ACADS/HADH/OXCT1/ALDH5A1	5
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/668	37/8135	0.07859	0.1802	0.1152	ASS1/GOT2/GFPT1/ALDH5A1/ASPA/GOT1	6
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	6/668	37/8135	0.07859	0.1802	0.1152	PRKCB/NR3C2/MAPK3/NEDD4L/INSR/HSD11B2	6
KEGG	hsa05143	African trypanosomiasis	6/668	37/8135	0.07859	0.1802	0.1152	PLCB1/HBB/ICAM1/PRKCB/IL1B/MYD88	6
KEGG	hsa04270	Vascular smooth muscle contraction	16/668	134/8135	0.08193	0.1865	0.1193	PLCB1/CALD1/MYL6B/PRKCB/ADCY9/MAPK3/GNA11/MYH11/MYH10/MYL9/ADCY6/ACTA2/PRKG1/PRKCH/AGTR1/ADCY1	16
KEGG	hsa04932	Non-alcoholic fatty liver disease	18/668	155/8135	0.08398	0.1898	0.1214	ADIPOQ/AKT3/IL1B/ADIPOR2/XBP1/CXCL8/NFKB1/COX7A1/INSR/COX6A2/MAPK10/MAPK13/CASP7/NDUFB7/NDUFV1/RXRA/UQCRC1/JUN	18
KEGG	hsa05214	Glioma	10/668	75/8135	0.08524	0.1913	0.1223	TGFA/EGFR/AKT3/PRKCB/MAPK3/CCND1/PLCG2/CDK4/NRAS/PDGFRA	10
KEGG	hsa05330	Allograft rejection	6/668	38/8135	0.08718	0.1943	0.1243	GZMB/CD40/HLA-DOB/HLA-DMA/HLA-DMB/CD86	6
KEGG	hsa04310	Wnt signaling pathway	19/668	167/8135	0.09054	0.2004	0.1282	PLCB1/RAC2/WIF1/PRKCB/TCF7/TCF7L2/SMAD3/CCND2/SFRP4/FZD2/CCND1/FZD7/LRP5/MAPK10/CTNNBIP1/SFRP1/CBY1/PPP3CC/JUN	19
KEGG	hsa04390	Hippo signaling pathway	18/668	157/8135	0.09225	0.2028	0.1297	WWTR1/TGFB2/BIRC3/TCF7/TCF7L2/SMAD3/CCND2/FZD2/CCND1/SMAD1/ID1/DLG5/BMP4/FZD7/SERPINE1/BMPR1A/ITGB2/AMOT	18
KEGG	hsa01523	Antifolate resistance	5/668	30/8135	0.09484	0.2068	0.1322	ABCC3/IL1B/NFKB1/ABCC5/IKBKG	5
KEGG	hsa04910	Insulin signaling pathway	16/668	137/8135	0.09533	0.2068	0.1322	FOXO1/SH2B2/PPP1R3C/PCK1/AKT3/HK2/MAPK3/PYGM/PYGB/INSR/RAPGEF1/BAD/MAPK10/PTPRF/NRAS/PCK2	16
KEGG	hsa04613	Neutrophil extracellular trap formation	21/668	190/8135	0.09861	0.2124	0.1358	PLCB1/RAC2/AKT3/PRKCB/MAPK3/SELPLG/ITGAL/NFKB1/AQP9/PLCG2/CASP4/FCGR2A/HDAC1/TLR2/SLC25A4/HDAC4/MAPK13/ITGB2/NCF2/SELP/ELANE	21
KEGG	hsa05213	Endometrial cancer	8/668	58/8135	0.09989	0.2138	0.1367	EGFR/AKT3/TCF7/TCF7L2/MAPK3/CCND1/BAD/NRAS	8
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	24/668	223/8135	0.1027	0.2183	0.1396	VEGFA/EGFR/AKT3/MAPK3/NFKBIA/NFKB1/COX7A1/HIF1A/GSTA4/NQO1/COX6A2/BAD/MAPK10/SLC25A4/MAPK13/LPO/GSTT1/NDUFB7/NDUFV1/NCF2/NRAS/IKBKG/UQCRC1/JUN	24
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	7/668	49/8135	0.1035	0.2185	0.1397	CYB5R1/HK2/CYB5R3/GFPT1/MPI/HEXA/UGDH	7
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	12/668	98/8135	0.1047	0.2192	0.1402	PLCB1/PRKCB/IL1B/ADCY9/PLCG2/ADCY6/MAPK10/NGF/PRKCH/MAPK13/PTGER2/ADCY1	12
KEGG	hsa00052	Galactose metabolism	5/668	31/8135	0.1059	0.2192	0.1402	AKR1B1/PFKM/HK2/B4GALT2/AKR1B10	5
KEGG	hsa05310	Asthma	5/668	31/8135	0.1059	0.2192	0.1402	MS4A2/CD40/HLA-DOB/HLA-DMA/HLA-DMB	5
KEGG	hsa04935	Growth hormone synthesis, secretion and action	14/668	119/8135	0.1084	0.223	0.1426	CREB3L2/PLCB1/AKT3/PRKCB/ADCY9/MAPK3/GNA11/PLCG2/ADCY6/MAPK10/STAT1/MAPK13/NRAS/ADCY1	14
KEGG	hsa04216	Ferroptosis	6/668	41/8135	0.1159	0.2369	0.1515	GPX4/SLC39A8/CP/SLC39A14/PCBP2/TFRC	6
KEGG	hsa04142	Lysosome	15/668	132/8135	0.1232	0.2494	0.1594	LITAF/CTSD/CTSC/NPC1/CTSL/CTSH/CTSF/AP1B1/LAMP3/HEXA/LGMN/PLA2G15/ATP6V0D1/HYAL1/NAGA	15
KEGG	hsa04916	Melanogenesis	12/668	101/8135	0.1235	0.2494	0.1594	CREB3L2/PLCB1/PRKCB/TCF7/TCF7L2/ADCY9/MAPK3/FZD2/ADCY6/FZD7/NRAS/ADCY1	12
KEGG	hsa04921	Oxytocin signaling pathway	17/668	154/8135	0.1284	0.2576	0.1647	PLCB1/EGFR/MYL6B/PRKCB/EEF2/ADCY9/MAPK3/CCND1/CD38/RGS2/MYL9/ADCY6/MAPK7/NRAS/PPP3CC/JUN/ADCY1	17
KEGG	hsa05218	Melanoma	9/668	72/8135	0.1338	0.2667	0.1705	EGFR/AKT3/MAPK3/CCND1/FGFR1/CDK4/BAD/NRAS/PDGFRA	9
KEGG	hsa04350	TGF-beta signaling pathway	11/668	94/8135	0.1468	0.2909	0.186	TGFB2/SMAD3/MAPK3/ID3/SMAD1/ID1/ID4/BMP4/BMPR1A/SMAD6/INHBB	11
KEGG	hsa04110	Cell cycle	14/668	126/8135	0.1511	0.2971	0.19	TGFB2/SMAD3/CCND2/CDC25B/CCND1/CDKN2C/PTTG1/CCNA2/CDK4/CCNB1/HDAC1/PLK1/CDC6/CCNB2	14
KEGG	hsa04929	GnRH secretion	8/668	64/8135	0.1518	0.2971	0.19	SPP1/PLCB1/AKT3/PRKCB/MAPK3/GNA11/KCNN3/NRAS	8
KEGG	hsa04918	Thyroid hormone synthesis	9/668	75/8135	0.1598	0.3103	0.1984	CREB3L2/PLCB1/PRKCB/GPX3/ADCY9/HSPA5/ADCY6/GPX1/ADCY1	9
KEGG	hsa02010	ABC transporters	6/668	45/8135	0.1605	0.3103	0.1984	ABCC3/ABCA8/TAP1/ABCA3/ABCG1/ABCC5	6
KEGG	hsa05231	Choline metabolism in cancer	11/668	98/8135	0.179	0.344	0.22	RAC2/EGFR/AKT3/PRKCB/MAPK3/HIF1A/MAPK10/NRAS/PDGFRA/LYPLA1/JUN	11
KEGG	hsa00240	Pyrimidine metabolism	7/668	58/8135	0.1958	0.3718	0.2378	ENPP1/HDDC2/DCK/NME3/TYMP/TK2/ASMTL	7
KEGG	hsa00480	Glutathione metabolism	7/668	58/8135	0.1958	0.3718	0.2378	HPGDS/GPX3/GPX4/GSTA4/GPX1/PGD/GSTT1	7
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	3/668	19/8135	0.2011	0.379	0.2423	GOT2/BCAT1/GOT1	3
KEGG	hsa04934	Cushing syndrome	16/668	155/8135	0.2025	0.379	0.2423	CREB3L2/PLCB1/EGFR/TCF7/TCF7L2/ADCY9/MAPK3/FZD2/GNA11/CCND1/CDKN2C/ADCY6/CDK4/FZD7/AGTR1/ADCY1	16
KEGG	hsa04924	Renin secretion	8/668	69/8135	0.2031	0.379	0.2423	PLCB1/PDE1A/ADORA1/ADCY6/AQP1/AGTR1/PTGER2/PPP3CC	8
KEGG	hsa04725	Cholinergic synapse	12/668	113/8135	0.2158	0.4004	0.256	CREB3L2/PLCB1/AKT3/PRKCB/ADCY9/MAPK3/GNA11/ADCY6/NRAS/GNG12/CHRM3/ADCY1	12
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/668	20/8135	0.2232	0.4099	0.2621	UST/XYLT1/CHST3	3
KEGG	hsa04530	Tight junction	17/668	169/8135	0.2236	0.4099	0.2621	MYL6B/CLDN7/ACTN1/NEDD4L/MYL2/CCND1/MYH11/MYH10/MYL9/HCLS1/CDK4/MAPK10/CTTN/ARPC3/AMOTL2/JUN/AMOT	17
KEGG	hsa04979	Cholesterol metabolism	6/668	50/8135	0.2247	0.4099	0.2621	LPL/LIPC/NPC1/APOC1/APOE/VAPA	6
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/668	11/8135	0.2269	0.4114	0.2631	HPD/NQO1	2
KEGG	hsa00030	Pentose phosphate pathway	4/668	30/8135	0.2292	0.4134	0.2644	PFKM/RGN/PGD/ALDOA	4
KEGG	hsa00561	Glycerolipid metabolism	7/668	61/8135	0.2321	0.4139	0.2647	LPL/AKR1B1/GK/LIPC/AKR1B10/AGPAT1/ALDH3A2	7
KEGG	hsa00590	Arachidonic acid metabolism	7/668	61/8135	0.2321	0.4139	0.2647	LTC4S/PTGS1/HPGDS/GPX3/GPX1/PTGDS/ALOX5	7
KEGG	hsa01200	Carbon metabolism	12/668	115/8135	0.2335	0.414	0.2648	ALDH6A1/PFKM/HK2/ECHS1/RGN/GOT2/ACADS/PC/GOT1/PGD/SDS/ALDOA	12
KEGG	hsa00982	Drug metabolism - cytochrome P450	8/668	72/8135	0.2368	0.4176	0.267	MAOA/HPGDS/ADH1B/ADH1A/ADH1C/ALDH3B1/GSTA4/GSTT1	8
KEGG	hsa00770	Pantothenate and CoA biosynthesis	3/668	21/8135	0.2457	0.431	0.2756	ENPP1/BCAT1/ALDH3A2	3
KEGG	hsa01524	Platinum drug resistance	8/668	73/8135	0.2484	0.431	0.2756	AKT3/BIRC3/REV3L/MAPK3/ERCC1/GSTA4/BAD/GSTT1	8
KEGG	hsa04115	p53 signaling pathway	8/668	73/8135	0.2484	0.431	0.2756	TNFRSF10B/CCND2/CCND1/CDK4/CCNB1/SERPINE1/SIVA1/CCNB2	8
KEGG	hsa04922	Glucagon signaling pathway	11/668	107/8135	0.2618	0.4518	0.2889	CREB3L2/FOXO1/PLCB1/PCK1/AKT3/PFKM/SIK1/PYGM/PYGB/PPP3CC/PCK2	11
KEGG	hsa00640	Propanoate metabolism	4/668	32/8135	0.2661	0.4549	0.2909	ALDH6A1/ECHS1/ACADS/BCKDHA	4
KEGG	hsa05320	Autoimmune thyroid disease	6/668	53/8135	0.2667	0.4549	0.2909	GZMB/CD40/HLA-DOB/HLA-DMA/HLA-DMB/CD86	6
KEGG	hsa00220	Arginine biosynthesis	3/668	22/8135	0.2686	0.4549	0.2909	ASS1/GOT2/GOT1	3
KEGG	hsa01230	Biosynthesis of amino acids	8/668	75/8135	0.2722	0.4549	0.2909	PFKM/ASS1/GOT2/PC/BCAT1/GOT1/SDS/ALDOA	8
KEGG	hsa04024	cAMP signaling pathway	21/668	221/8135	0.2723	0.4549	0.2909	CREB3L2/RAC2/AKT3/FXYD1/PAK1/ADCY9/MAPK3/ADORA1/PLN/NFKBIA/NFKB1/MYL9/ADCY6/F2R/ATP2A1/BAD/MAPK10/VAV1/PTGER2/JUN/ADCY1	21
KEGG	hsa04911	Insulin secretion	9/668	86/8135	0.2728	0.4549	0.2909	CREB3L2/PLCB1/PRKCB/ADCY9/GNA11/ADCY6/KCNN3/CHRM3/ADCY1	9
KEGG	hsa01240	Biosynthesis of cofactors	15/668	153/8135	0.2735	0.4549	0.2909	GCH1/RGN/ALPL/HPD/BCAT1/NQO1/MPI/PPOX/UROD/DHRS3/AK1/NME3/MTHFD2/ALDH3A2/UGDH	15
KEGG	hsa04152	AMPK signaling pathway	12/668	120/8135	0.28	0.4633	0.2962	CREB3L2/FOXO1/ADIPOQ/PCK1/AKT3/EEF2/PFKM/ADIPOR2/CCND1/INSR/CCNA2/PCK2	12
KEGG	hsa04927	Cortisol synthesis and secretion	7/668	65/8135	0.2836	0.4668	0.2985	CREB3L2/PLCB1/ADCY9/GNA11/ADCY6/AGTR1/ADCY1	7
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	20/668	212/8135	0.2897	0.4741	0.3032	CREB3L2/VEGFA/EGFR/AKT3/PRKCB/ADCY9/MAPK3/NFKB1/CCND1/AR/ADCY6/GSTA4/BAD/GSTT1/NRAS/RXRA/IKBKE/CDC6/JUN/ADCY1	20
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	3/668	23/8135	0.2916	0.4741	0.3032	PCK1/AQP1/PCK2	3
KEGG	hsa04962	Vasopressin-regulated water reabsorption	5/668	44/8135	0.2924	0.4741	0.3032	CREB3L2/ADCY9/ARHGDIB/ADCY6/DCTN2	5
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/668	78/8135	0.309	0.498	0.3185	HPGDS/ADH1B/ADH1A/ADH1C/ALDH3B1/AKR7A2/GSTA4/GSTT1	8
KEGG	hsa04720	Long-term potentiation	7/668	67/8135	0.3103	0.498	0.3185	PLCB1/PRKCB/MAPK3/PPP1R1A/NRAS/PPP3CC/ADCY1	7
KEGG	hsa05224	Breast cancer	14/668	147/8135	0.3206	0.5119	0.3274	EGFR/AKT3/TCF7/TCF7L2/NFKB2/MAPK3/FZD2/CCND1/FGFR1/CDK4/FZD7/LRP5/NRAS/JUN	14
KEGG	hsa04930	Type II diabetes mellitus	5/668	46/8135	0.3255	0.5167	0.3304	ADIPOQ/HK2/MAPK3/INSR/MAPK10	5
KEGG	hsa04972	Pancreatic secretion	10/668	102/8135	0.3267	0.5167	0.3304	PLCB1/CPA3/PRKCB/ADCY9/CD38/CPB1/ADCY6/ATP2A1/CHRM3/ADCY1	10
KEGG	hsa05032	Morphine addiction	9/668	91/8135	0.3305	0.5201	0.3325	GRK5/GABRB1/PDE1A/PRKCB/ADCY9/ADORA1/ADCY6/GNG12/ADCY1	9
KEGG	hsa00983	Drug metabolism - other enzymes	8/668	80/8135	0.3341	0.5232	0.3346	HPRT1/GSTA4/NME3/GSTT1/IMPDH1/IMPDH2/TYMP/TK2	8
KEGG	hsa05031	Amphetamine addiction	7/668	69/8135	0.3375	0.5259	0.3363	CREB3L2/MAOA/PRKCB/HDAC1/PPP3CC/SLC18A2/JUN	7
KEGG	hsa04973	Carbohydrate digestion and absorption	5/668	47/8135	0.3423	0.5283	0.3378	PLCB1/AKT3/PRKCB/HK2/SLC2A5	5
KEGG	hsa00500	Starch and sucrose metabolism	4/668	36/8135	0.3423	0.5283	0.3378	ENPP1/HK2/PYGM/PYGB	4
KEGG	hsa04915	Estrogen signaling pathway	13/668	138/8135	0.344	0.5283	0.3378	CREB3L2/PLCB1/TGFA/EGFR/HBEGF/AKT3/ADCY9/CTSD/MAPK3/ADCY6/NRAS/JUN/ADCY1	13
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/668	15/8135	0.3523	0.536	0.3427	HEXA/NAGA	2
KEGG	hsa00730	Thiamine metabolism	2/668	15/8135	0.3523	0.536	0.3427	ALPL/AK1	2
KEGG	hsa04970	Salivary secretion	9/668	93/8135	0.3542	0.5363	0.343	PLCB1/PRKCB/ADCY9/CD38/ADCY6/PRKG1/LPO/CHRM3/ADCY1	9
KEGG	hsa01250	Biosynthesis of nucleotide sugars	4/668	37/8135	0.3615	0.5449	0.3484	HK2/GFPT1/MPI/UGDH	4
KEGG	hsa04730	Long-term depression	6/668	60/8135	0.3704	0.5556	0.3553	PLCB1/PRKCB/MAPK3/GNA11/PRKG1/NRAS	6
KEGG	hsa05030	Cocaine addiction	5/668	49/8135	0.3758	0.5611	0.3588	CREB3L2/MAOA/NFKB1/SLC18A2/JUN	5
KEGG	hsa04137	Mitophagy - animal	7/668	72/8135	0.3788	0.5629	0.3599	GABARAPL1/HIF1A/PINK1/MAPK10/NRAS/BNIP3/JUN	7
KEGG	hsa00062	Fatty acid elongation	3/668	27/8135	0.3843	0.5685	0.3635	ECHS1/TECR/HADH	3
KEGG	hsa00562	Inositol phosphate metabolism	7/668	73/8135	0.3926	0.5755	0.368	PLCB1/ALDH6A1/PIP4K2B/PLCG2/INPP5F/MINPP1/INPP5D	7
KEGG	hsa05110	Vibrio cholerae infection	5/668	50/8135	0.3926	0.5755	0.368	ADCY9/PLCG2/KDELR3/KDELR1/ATP6V0D1	5
KEGG	hsa04144	Endocytosis	22/668	251/8135	0.4064	0.5914	0.3782	CXCR4/GRK5/IL2RG/AGAP1/IL2RB/EGFR/BIN1/PSD3/SMAD3/NEDD4L/CCR5/DNM1/CAV3/ACAP1/RAB22A/ARPC3/ARF3/TFRC/FGFR3/IL2RA/PDGFRA/PSD4	22
KEGG	hsa00330	Arginine and proline metabolism	5/668	51/8135	0.4094	0.5914	0.3782	MAOA/GOT2/GOT1/CKMT2/ALDH3A2	5
KEGG	hsa04913	Ovarian steroidogenesis	5/668	51/8135	0.4094	0.5914	0.3782	ADCY9/INSR/ADCY6/ALOX5/ADCY1	5
KEGG	hsa00120	Primary bile acid biosynthesis	2/668	17/8135	0.4127	0.5914	0.3782	CH25H/ACOX2	2
KEGG	hsa00910	Nitrogen metabolism	2/668	17/8135	0.4127	0.5914	0.3782	CA12/CA3	2
KEGG	hsa03250	Viral life cycle - HIV-1	6/668	63/8135	0.4157	0.593	0.3792	CXCR4/CCR5/PIN1/MX2/PSIP1/SUPT5H	6
KEGG	hsa00260	Glycine, serine and threonine metabolism	4/668	40/8135	0.419	0.5951	0.3806	MAOA/AOC3/GRHPR/SDS	4
KEGG	hsa04971	Gastric acid secretion	7/668	76/8135	0.434	0.6137	0.3925	PLCB1/PRKCB/ADCY9/ATP4B/ADCY6/CHRM3/ADCY1	7
KEGG	hsa00511	Other glycan degradation	2/668	18/8135	0.4418	0.6205	0.3968	MAN2B2/HEXA	2
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/668	53/8135	0.4426	0.6205	0.3968	PLCB1/PRKCB/ADCY9/DNM1/ADCY6	5
KEGG	hsa05100	Bacterial invasion of epithelial cells	7/668	77/8135	0.4477	0.6229	0.3983	DOCK1/HCLS1/DNM1/CAV3/ITGA5/CTTN/ARPC3	7
KEGG	hsa00020	Citrate cycle (TCA cycle)	3/668	30/8135	0.4521	0.6229	0.3983	PCK1/PC/PCK2	3
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/668	30/8135	0.4521	0.6229	0.3983	RGN/ALDH3A2/UGDH	3
KEGG	hsa05226	Gastric cancer	13/668	149/8135	0.4522	0.6229	0.3983	TGFB2/EGFR/AKT3/TCF7/TCF7L2/SMAD3/MAPK3/FZD2/CCND1/FZD7/LRP5/NRAS/RXRA	13
KEGG	hsa00380	Tryptophan metabolism	4/668	42/8135	0.4566	0.6264	0.4006	MAOA/ECHS1/HADH/ALDH3A2	4
KEGG	hsa04724	Glutamatergic synapse	10/668	114/8135	0.4623	0.6315	0.4038	PLCB1/PRKCB/SHANK2/ADCY9/MAPK3/ADCY6/HOMER3/GNG12/PPP3CC/ADCY1	10
KEGG	hsa00531	Glycosaminoglycan degradation	2/668	19/8135	0.4702	0.6395	0.4089	HEXA/HYAL1	2
KEGG	hsa04726	Serotonergic synapse	10/668	115/8135	0.4736	0.6409	0.4098	PLCB1/MAOA/GABRB1/PTGS1/PRKCB/MAPK3/NRAS/GNG12/ALOX5/SLC18A2	10
KEGG	hsa00860	Porphyrin metabolism	4/668	43/8135	0.4752	0.6409	0.4098	BLVRA/CP/PPOX/UROD	4
KEGG	hsa04215	Apoptosis - multiple species	3/668	32/8135	0.4955	0.6655	0.4255	BIRC3/MAPK10/CASP7	3
KEGG	hsa04114	Oocyte meiosis	11/668	131/8135	0.5155	0.6894	0.4409	ADCY9/MAPK3/AR/ADCY6/PTTG1/CCNB1/MAPK13/PLK1/PPP3CC/ADCY1/CCNB2	11
KEGG	hsa00040	Pentose and glucuronate interconversions	3/668	34/8135	0.5371	0.7124	0.4556	AKR1B1/AKR1B10/UGDH	3
KEGG	hsa03020	RNA polymerase	3/668	34/8135	0.5371	0.7124	0.4556	POLR2E/POLR2I/POLR1C	3
KEGG	hsa03420	Nucleotide excision repair	4/668	47/8135	0.5465	0.7195	0.4601	ERCC1/CETN2/RAD23B/CUL4A	4
KEGG	hsa04713	Circadian entrainment	8/668	97/8135	0.5488	0.7195	0.4601	PLCB1/PRKCB/ADCY9/MAPK3/ADCY6/PRKG1/GNG12/ADCY1	8
KEGG	hsa04217	Necroptosis	13/668	159/8135	0.5491	0.7195	0.4601	TNFAIP3/IFNAR2/TNFRSF10B/BIRC3/IL1B/PYGM/PYGB/STAT4/TNFSF10/MAPK10/STAT1/SLC25A4/NLRP3	13
KEGG	hsa04925	Aldosterone synthesis and secretion	8/668	98/8135	0.5607	0.7311	0.4675	CREB3L2/PLCB1/PRKCB/ADCY9/GNA11/ADCY6/AGTR1/ADCY1	8
KEGG	hsa04723	Retrograde endocannabinoid signaling	12/668	148/8135	0.5625	0.7311	0.4675	PLCB1/GABRB1/PRKCB/ADCY9/MAPK3/ADCY6/MAPK10/MAPK13/NDUFB7/NDUFV1/GNG12/ADCY1	12
KEGG	hsa03060	Protein export	2/668	23/8135	0.5742	0.7403	0.4734	HSPA5/SEC63	2
KEGG	hsa04614	Renin-angiotensin system	2/668	23/8135	0.5742	0.7403	0.4734	CPA3/AGTR1	2
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	3/668	36/8135	0.5767	0.7405	0.4735	ENPP1/NAMPT/CD38	3
KEGG	hsa00310	Lysine degradation	5/668	63/8135	0.5986	0.7626	0.4876	EZH1/ECHS1/HADH/EHMT2/ALDH3A2	5
KEGG	hsa05217	Basal cell carcinoma	5/668	63/8135	0.5986	0.7626	0.4876	TCF7/TCF7L2/FZD2/BMP4/FZD7	5
KEGG	hsa04727	GABAergic synapse	7/668	89/8135	0.6041	0.7635	0.4882	GABRB1/PRKCB/ADCY9/GABARAPL1/ADCY6/GNG12/ADCY1	7
KEGG	hsa04976	Bile secretion	7/668	89/8135	0.6041	0.7635	0.4882	ABCC3/ADCY9/AQP9/ADCY6/AQP1/RXRA/ADCY1	7
KEGG	hsa04140	Autophagy - animal	11/668	141/8135	0.6162	0.7757	0.496	AKT3/CTSD/MAPK3/CTSL/GABARAPL1/HIF1A/BAD/MAPK10/DDIT4/NRAS/BNIP3	11
KEGG	hsa05010	Alzheimer disease	30/668	384/8135	0.6429	0.8061	0.5155	PLCB1/LPL/AKT3/IL1B/XBP1/MAPK3/FZD2/NFKB1/COX7A1/SLC39A8/INSR/ATF6/SLC39A14/ATP2A1/FZD7/LRP5/COX6A2/BAD/MAPK10/APOE/SLC39A7/SLC25A4/CASP7/NDUFB7/NDUFV1/NRAS/IKBKG/PPP3CC/UQCRC1/CHRM3	30
KEGG	hsa05206	MicroRNAs in cancer	24/668	310/8135	0.6515	0.8116	0.519	TGFB2/VEGFA/EGFR/PRKCB/BCL2L2/MAPK3/CCND2/CDC25B/NFKB1/CCND1/CD44/PLCG2/ITGA5/PIM1/EFNA5/MAPK7/HDAC1/TIMP3/HDAC4/DDIT4/FGFR3/NRAS/PDGFRA/ST14	24
KEGG	hsa04728	Dopaminergic synapse	10/668	132/8135	0.6523	0.8116	0.519	CREB3L2/PLCB1/MAOA/AKT3/PRKCB/MAPK10/MAPK13/GNG12/PPP3CC/SLC18A2	10
KEGG	hsa04141	Protein processing in endoplasmic reticulum	13/668	171/8135	0.6564	0.8135	0.5202	CRYAB/XBP1/BAG1/HSPA5/ATF6/UBE4B/MAPK10/UBE2J1/SEC63/RAD23B/GANAB/WFS1/HERPUD1	13
KEGG	hsa04966	Collecting duct acid secretion	2/668	27/8135	0.6626	0.8181	0.5231	ATP4B/ATP6V0D1	2
KEGG	hsa00830	Retinol metabolism	5/668	68/8135	0.6667	0.82	0.5244	ADH1B/ADH1A/ADH1C/PNPLA4/DHRS3	5
KEGG	hsa04146	Peroxisome	6/668	82/8135	0.6754	0.8275	0.5291	ECH1/CRAT/PEX19/SLC27A2/ACOX2/PMVK	6
KEGG	hsa04340	Hedgehog signaling pathway	4/668	56/8135	0.6861	0.8374	0.5355	CDON/CCND2/CCND1/GAS1	4
KEGG	hsa05322	Systemic lupus erythematosus	10/668	136/8135	0.6891	0.8379	0.5358	CD40/ACTN1/FCGR2A/HLA-DOB/HLA-DMA/HLA-DMB/C6/CD86/C7/ELANE	10
KEGG	hsa05012	Parkinson disease	20/668	266/8135	0.695	0.8396	0.5369	MAOA/DAXX/XBP1/HSPA5/COX7A1/SLC39A8/TRAP1/PINK1/ATF6/UCHL1/SLC39A14/COX6A2/MAPK10/UBE2J1/SLC39A7/SLC25A4/NDUFB7/NDUFV1/UQCRC1/SLC18A2	20
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/668	14/8135	0.699	0.8396	0.5369	B4GALT2	1
KEGG	hsa01212	Fatty acid metabolism	4/668	57/8135	0.6996	0.8396	0.5369	ECHS1/TECR/ACADS/HADH	4
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/668	29/8135	0.701	0.8396	0.5369	WWTR1/PAK1	2
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/668	15/8135	0.7237	0.8636	0.5523	HEXA	1
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	36/668	476/8135	0.727	0.8643	0.5527	PLCB1/TNFRSF1B/PRKCB/GPX3/DCTN3/IL1B/DAXX/XBP1/MAPK3/FZD2/NFKB1/HSPA5/COX7A1/TRAP1/PINK1/ATF6/UCHL1/GPX1/ATP2A1/FZD7/LRP5/COX6A2/HIP1/BAD/MAPK10/UBE2J1/SLC25A4/MAPK13/CASP7/DCTN2/NDUFB7/NDUFV1/NRAS/PPP3CC/UQCRC1/CHRM3	36
KEGG	hsa05020	Prion disease	20/668	273/8135	0.738	0.8742	0.559	CREB3L2/CCL5/RAC2/IL1B/MAPK3/HSPA5/COX7A1/CAV3/COX6A2/BAD/MAPK10/SLC25A4/MAPK13/C6/C7/NDUFB7/NDUFV1/NCF2/PPP3CC/UQCRC1	20
KEGG	hsa04150	mTOR signaling pathway	11/668	156/8135	0.7449	0.8777	0.5612	AKT3/PRKCB/MAPK3/FZD2/INSR/SLC7A5/FZD7/LRP5/DDIT4/NRAS/NPRL3	11
KEGG	hsa00430	Taurine and hypotaurine metabolism	1/668	16/8135	0.7465	0.8777	0.5612	CDO1	1
KEGG	hsa00514	Other types of O-glycan biosynthesis	3/668	47/8135	0.7538	0.8831	0.5647	GALNT10/B4GALT2/LFNG	3
KEGG	hsa00450	Selenocompound metabolism	1/668	17/8135	0.7673	0.8957	0.5727	PAPSS2	1
KEGG	hsa04721	Synaptic vesicle cycle	5/668	78/8135	0.7787	0.9057	0.5791	STXBP1/DNM1/UNC13B/ATP6V0D1/SLC18A2	5
KEGG	hsa00510	N-Glycan biosynthesis	3/668	50/8135	0.7903	0.9158	0.5856	B4GALT2/MGAT5/GANAB	3
KEGG	hsa04070	Phosphatidylinositol signaling system	6/668	97/8135	0.8189	0.9403	0.6013	PLCB1/PRKCB/PIP4K2B/PLCG2/INPP5F/INPP5D	6
KEGG	hsa00100	Steroid biosynthesis	1/668	20/8135	0.8202	0.9403	0.6013	LBR	1
KEGG	hsa00670	One carbon pool by folate	1/668	20/8135	0.8202	0.9403	0.6013	MTHFD2	1
KEGG	hsa03460	Fanconi anemia pathway	3/668	54/8135	0.8318	0.9502	0.6076	REV3L/ERCC1/FANCC	3
KEGG	hsa00513	Various types of N-glycan biosynthesis	2/668	39/8135	0.8418	0.9583	0.6128	B4GALT2/HEXA	2
KEGG	hsa00900	Terpenoid backbone biosynthesis	1/668	22/8135	0.8486	0.9619	0.6151	PMVK	1
KEGG	hsa05168	Herpes simplex virus 1 infection	35/668	495/8135	0.851	0.9619	0.6151	CCL5/IFNAR2/TAP1/ZNF135/AKT3/BIRC3/IL1B/DAXX/NFKBIA/NFKB1/ZNF43/MYD88/CFP/ZNF248/ZNF85/ITGA5/ZNF205/ZNF101/BAD/HLA-DOB/TLR2/SRSF8/STAT1/HLA-DMA/HLA-DMB/IRF7/ZNF91/TAPBP/TRAF3/TNFSF14/NXF1/CCL2/OAS2/IKBKG/IKBKE	35
KEGG	hsa04974	Protein digestion and absorption	6/668	103/8135	0.86	0.9664	0.618	CPA3/CPB1/SLC7A8/COL1A1/COL3A1/COL4A1	6
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/668	23/8135	0.861	0.9664	0.618	B4GALT2	1
KEGG	hsa04714	Thermogenesis	15/668	232/8135	0.8673	0.97	0.6203	CREB3L2/PLIN1/ADCY9/COX7A1/ADCY6/FGFR1/SMARCD3/COX6A2/PRKG1/MAPK13/NDUFB7/NDUFV1/NRAS/UQCRC1/ADCY1	15
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/668	24/8135	0.8725	0.9724	0.6218	XYLT1	1
KEGG	hsa04975	Fat digestion and absorption	2/668	43/8135	0.8789	0.9763	0.6243	GOT2/AGPAT1	2
KEGG	hsa03013	Nucleocytoplasmic transport	6/668	108/8135	0.8881	0.9821	0.628	SAP18/UPF3A/EEF1A2/CASC3/NXF1/NUP210	6
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/668	26/8135	0.8926	0.9821	0.628	GPAA1	1
KEGG	hsa03018	RNA degradation	4/668	79/8135	0.8985	0.9821	0.628	PFKM/BTG2/CNOT1/CNOT4	4
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/668	27/8135	0.9015	0.9821	0.628	B4GALT2	1
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	1/668	27/8135	0.9015	0.9821	0.628	TECR	1
KEGG	hsa04120	Ubiquitin mediated proteolysis	8/668	142/8135	0.9063	0.9821	0.628	HUWE1/BIRC3/NEDD4L/UBE4B/UBE2J1/RHOBTB1/CUL4A/UBA3	8
KEGG	hsa03015	mRNA surveillance pathway	5/668	97/8135	0.9093	0.9821	0.628	SAP18/UPF3A/GSPT1/CASC3/NXF1	5
KEGG	hsa05017	Spinocerebellar ataxia	8/668	143/8135	0.9102	0.9821	0.628	PLCB1/AKT3/PRKCB/XBP1/ATP2A1/MAPK10/SLC25A4/KAT5	8
KEGG	hsa00564	Glycerophospholipid metabolism	5/668	98/8135	0.9138	0.9821	0.628	PNPLA6/PLD3/AGPAT1/PLA2G15/LYPLA1	5
KEGG	hsa00565	Ether lipid metabolism	2/668	49/8135	0.9198	0.9821	0.628	PLD3/PLA2G7	2
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	1/668	30/8135	0.9239	0.9821	0.628	GRHPR	1
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	3/668	69/8135	0.9306	0.9821	0.628	HPGDS/GSTA4/GSTT1	3
KEGG	hsa04742	Taste transduction	4/668	86/8135	0.9309	0.9821	0.628	PLCB1/PDE1A/ADCY6/CHRM3	4
KEGG	hsa00190	Oxidative phosphorylation	7/668	134/8135	0.9316	0.9821	0.628	COX7A1/ATP4B/COX6A2/NDUFB7/NDUFV1/ATP6V0D1/UQCRC1	7
KEGG	hsa00600	Sphingolipid metabolism	2/668	52/8135	0.9349	0.9821	0.628	UGCG/HEXA	2
KEGG	hsa04136	Autophagy - other	1/668	32/8135	0.9359	0.9821	0.628	GABARAPL1	1
KEGG	hsa03410	Base excision repair	1/668	33/8135	0.9412	0.9821	0.628	PARP3	1
KEGG	hsa04130	SNARE interactions in vesicular transport	1/668	33/8135	0.9412	0.9821	0.628	STX11	1
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	5/668	109/8135	0.9515	0.9821	0.628	RPP40/MDN1/FBL/NXF1/UTP18	5
KEGG	hsa05016	Huntington disease	18/668	306/8135	0.9528	0.9821	0.628	CREB3L2/PLCB1/GPX3/DCTN3/TGM2/COX7A1/GPX1/POLR2E/HDAC1/COX6A2/HIP1/MAPK10/SLC25A4/POLR2I/DCTN2/NDUFB7/NDUFV1/UQCRC1	18
KEGG	hsa05014	Amyotrophic lateral sclerosis	22/668	364/8135	0.9543	0.9821	0.628	TNFRSF1B/GPX3/DCTN3/DAXX/XBP1/ANXA11/HSPA5/COX7A1/PINK1/ATF6/GPX1/COX6A2/BAD/MAPK13/DCTN2/NDUFB7/NDUFV1/NXF1/NUP210/PFN2/PPP3CC/UQCRC1	22
KEGG	hsa00512	Mucin type O-glycan biosynthesis	1/668	36/8135	0.9546	0.9821	0.628	GALNT10	1
KEGG	hsa03030	DNA replication	1/668	36/8135	0.9546	0.9821	0.628	PRIM2	1
KEGG	hsa04330	Notch signaling pathway	2/668	59/8135	0.9605	0.9831	0.6287	LFNG/HDAC1	2
KEGG	hsa04978	Mineral absorption	2/668	60/8135	0.9632	0.9831	0.6287	STEAP1/MT1G	2
KEGG	hsa00140	Steroid hormone biosynthesis	2/668	61/8135	0.9658	0.9831	0.6287	HSD11B2/STS	2
KEGG	hsa05033	Nicotine addiction	1/668	40/8135	0.9678	0.9831	0.6287	GABRB1	1
KEGG	hsa05034	Alcoholism	9/668	187/8135	0.975	0.9873	0.6314	CREB3L2/MAOA/MAPK3/SLC29A1/HDAC1/HDAC4/NRAS/GNG12/SLC18A2	9
KEGG	hsa03040	Spliceosome	6/668	147/8135	0.9847	0.994	0.6356	SNRPA/SRSF8/PRPF8/CDC40/SART1/SNRPD2	6
KEGG	hsa04080	Neuroactive ligand-receptor interaction	17/668	353/8135	0.9958	1	0.6394	GABRB1/P2RY6/THRA/S1PR1/ADORA3/ADORA1/GZMA/PTAFR/NMB/VIPR1/F2R/GLRB/AGTR1/PTGER2/C3AR1/S1PR4/CHRM3	17
KEGG	hsa03010	Ribosome	4/668	158/8135	0.9993	1	0.6394	RPS5/RPL18/RPLP0/RPL13	4
KEGG	hsa04740	Olfactory transduction	5/668	440/8135	1	1	0.6394	PDE1A/NCALD/RGS2/PRKG1/OR2F1	5