ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04010	MAPK signaling pathway	94/1853	294/8135	0.0001427	0.0272	0.02169	HGF/MAPK8IP1/FGF16/NTF3/FGF18/RPS6KA5/FGFR2/CSF1R/MRAS/MAP2K6/PDGFA/DUSP16/MAPK3/PAK1/MAP2K5/PLA2G4F/RPS6KA6/EGFR/IL1R1/MAPK1/MAPK10/FGF1/FLT3LG/CACNA1H/PAK2/FGF7/ELK1/DUSP5/FGF10/MAP4K4/SRF/MAP3K8/FGF2/CACNB2/KRAS/PLA2G4A/GNG12/CACNG4/DUSP4/JUN/DUSP8/TGFB3/KITLG/MAP3K12/RAP1A/CDC25B/BDNF/PRKACB/RASGRP1/PDGFB/JMJD7-PLA2G4B/PPP3CB/HSPA6/FGF17/TGFBR2/FLNC/ARAF/ARRB1/FGF8/CSF1/MAPKAPK3/FGFR4/TGFBR1/FGFR1/ERBB4/CACNA2D3/ERBB2/AREG/IL1B/PTPN7/MAP2K1/RASGRF1/MKNK2/CACNA2D1/FGF6/RPS6KA3/CACNG5/GADD45G/MYD88/ARRB2/CRKL/PPP3R2/RASGRP2/CASP3/KIT/MAP3K4/PGF/RRAS2/MAP4K1/GADD45B/MAX/MAPK9/EPHA2/MAPK8	94
KEGG	hsa04921	Oxytocin signaling pathway	55/1853	154/8135	0.0001629	0.0272	0.02169	ADCY8/GUCY1A2/PPP1R12B/PLCB4/RGS2/PLCB1/NPR1/MAPK3/MAP2K5/PLA2G4F/EGFR/MAPK1/KCNJ5/CAMK1/KCNJ2/ELK1/PIK3R6/PRKAA2/CACNB2/CAMK1G/KRAS/PLA2G4A/CACNG4/JUN/ROCK1/CAMKK2/ADCY4/PRKACB/NFATC4/JMJD7-PLA2G4B/PPP3CB/GNAI1/RCAN1/KCNJ6/PPP1CB/GNAQ/MYL6B/PPP1CC/OXTR/PRKAB1/CACNA2D3/EEF2K/PIK3R5/PLCB2/CAMK4/MAP2K1/SRC/CACNA2D1/ADCY3/NOS3/CACNG5/PRKAG1/PPP3R2/PRKAB2/CD38	55
KEGG	hsa05226	Gastric cancer	52/1853	149/8135	0.0004616	0.04019	0.03205	HGF/FGF16/SHC2/WNT9A/FGF18/FGFR2/WNT16/WNT11/SHC3/MAPK3/DVL2/WNT10B/WNT2/EGFR/MAPK1/PIK3CB/CDK2/APC/FGF1/FGF7/FGF10/TCF7/FGF2/KRAS/TGFB3/CCNE1/AXIN1/JUP/SMAD2/ABCB1/FGF17/TGFBR2/CCNE2/ARAF/WNT4/FGF8/FRAT1/FZD1/FZD8/TGFBR1/ERBB2/CTNNA3/MAP2K1/FGF6/BCL2/BAK1/GADD45G/GAB1/APC2/WNT1/GADD45B/SMAD4	52
KEGG	hsa04022	cGMP-PKG signaling pathway	57/1853	167/8135	0.0004813	0.04019	0.03205	ADCY8/GUCY1A2/PDE3B/PLCB4/ADORA1/RGS2/PLCB1/AGTR1/ATP1A2/SLC8A1/ADRA2A/NPR1/MAPK3/ADRB2/MAPK1/KCNMB1/PIK3R6/SRF/PRKCE/KNG1/VASP/ATP1A3/ROCK1/EDNRB/ADCY4/CREB1/EDNRA/NFATC4/PPP3CB/ATP1B1/GNAI1/PPP1CB/NPPB/GNAQ/PPP1CC/ADRA2B/PIK3R5/PLCB2/ATP2B3/PPIF/MAP2K1/ADCY3/PRKG2/NOS3/ADRA1B/ATP2B2/MYH7/PPP3R2/CREB3L4/GTF2IRD1/PRKG1/VDAC3/FXYD2/CREB3L3/PDE3A/PDE2A/KCNJ8	57
KEGG	hsa04015	Rap1 signaling pathway	67/1853	210/8135	0.001314	0.07704	0.06143	ADCY8/HGF/PARD6B/THBS1/FGF16/GRIN2A/ITGB2/FGF18/PLCB4/FGFR2/PLCB1/CSF1R/RASSF5/MRAS/MAP2K6/PDGFA/PARD6A/MAPK3/MAGI3/EGFR/MAPK1/PIK3CB/FGF1/FGF7/EVL/FGF10/FGF2/SIPA1L2/ADORA2B/VASP/KRAS/LPAR4/KITLG/PLCE1/RAP1A/RAP1GAP/ADCY4/PDGFB/GNAI1/FGF17/DRD2/GNAQ/FGF8/CSF1/LPAR1/FGFR4/FGFR1/PLCB2/MAP2K1/RAPGEF1/TLN2/SRC/PRKD1/ADCY3/PFN2/FGF6/ADORA2A/RAPGEF5/MAGI1/RALB/CRKL/RASGRP2/KIT/PGF/ITGB3/PARD6G/EPHA2	67
KEGG	hsa00071	Fatty acid degradation	19/1853	43/8135	0.001478	0.07704	0.06143	ADH1A/ACSL5/ALDH3A2/HADH/ADH1C/ALDH1B1/ACADS/ADH5/HADHA/CPT1C/ACADSB/ALDH9A1/CYP2U1/ACOX3/ALDH2/ADH4/CPT2/ACAT2/ACSL1	19
KEGG	hsa04924	Renin secretion	27/1853	69/8135	0.001615	0.07704	0.06143	GUCY1A2/PDE3B/PLCB4/ADORA1/PLCB1/AGTR1/CLCA2/NPR1/ADRB2/ACE/PTGER2/CLCA1/PDE1B/KCNJ2/REN/AQP1/PRKACB/CREB1/EDNRA/PPP3CB/GNAI1/EDN1/GNAQ/PLCB2/PRKG2/PPP3R2/PDE3A	27
KEGG	hsa04020	Calcium signaling pathway	74/1853	240/8135	0.002146	0.08584	0.06844	ADCY8/HGF/FGF16/GRIN2A/HTR2A/FGF18/PLCB4/FGFR2/PLCB1/AGTR1/SLC8A1/PDGFA/ADRB2/P2RX7/STIM2/EGFR/CAMK1/CHRM1/PDE1B/FGF1/CACNA1H/FGF7/CHRM2/GRM1/FGF10/TNNC2/FGF2/PHKA1/PTGFR/ADORA2B/CAMK1G/MST1R/GRIN2C/GNA14/SPHK2/EDNRB/PLCE1/ADCY4/HTR2B/PRKACB/EDNRA/PDGFB/PPP3CB/PLCD3/FGF17/GNAQ/FGF8/OXTR/FGFR4/FGFR1/ERBB4/ERBB2/P2RX2/PLCB2/CAMK4/GRM5/ATP2B3/PPIF/ADCY3/FGF6/ADORA2A/NTRK3/NOS3/ADRA1B/MCOLN3/ATP2B2/P2RX4/PPP3R2/ITPKB/HRC/TRHR/CD38/VDAC3/CHRNA7	74
KEGG	hsa04810	Regulation of actin cytoskeleton	68/1853	218/8135	0.002313	0.08584	0.06844	FGF16/PPP1R12B/ITGB2/FGF18/ARHGEF4/FGFR2/ITGB8/MRAS/PDGFA/MAPK3/PAK1/ARHGEF7/MYH10/EGFR/MAPK1/PIK3CB/ITGA2/CHRM1/APC/FGF1/CYFIP2/PAK2/FGF7/CHRM2/FGF10/FGF2/MSN/KNG1/KRAS/GNG12/MYLPF/LPAR4/MYL7/ROCK1/ACTN1/PDGFB/SSH3/FGF17/PPP1CB/ABI2/ARAF/FGF8/SPATA13/MYH11/PPP1CC/CHRM4/LPAR1/FGFR4/NCKAP1L/FGFR1/ITGA9/TMSB4Y/SSH1/MAP2K1/SRC/PFN2/FGF6/CRKL/APC2/ITGA8/LIMK2/FGD3/DIAPH2/RRAS2/ITGA10/ITGB3/BAIAP2/LIMK1	68
KEGG	hsa04514	Cell adhesion molecules	49/1853	149/8135	0.002812	0.08802	0.07018	NLGN3/CD34/CLDN4/ITGB2/ITGB8/ICAM2/PTPRC/CDH4/NEGR1/SELL/CLDN9/HLA-DQA1/SPN/CDH15/ICAM3/LRRC4B/CDH5/CLDN23/CD274/NRCAM/CTLA4/PDCD1/CD99L2/CD276/HLA-DQA2/SELPLG/MPZL1/NRXN2/OCLN/ITGA9/CDH3/HLA-DOA/CD40/CLDN17/CLDN19/CD226/CLDN7/NRXN3/CLDN22/CLDN6/NLGN2/TIGIT/CLDN11/JAM2/ITGA8/ALCAM/NTNG2/CD40LG/NEO1	49
KEGG	hsa04977	Vitamin digestion and absorption	12/1853	24/8135	0.003159	0.08802	0.07018	PLB1/SLC19A3/BTD/APOA4/APOA1/TCN2/CUBN/ABCC1/SLC46A1/PNLIP/LMBRD1/SCARB1	12
KEGG	hsa05218	Melanoma	27/1853	72/8135	0.003307	0.08802	0.07018	HGF/FGF16/FGF18/PDGFA/MAPK3/EGFR/MAPK1/PIK3CB/MITF/FGF1/FGF7/FGF10/FGF2/KRAS/PDGFB/CDK6/FGF17/ARAF/FGF8/PTEN/FGFR1/MAP2K1/FGF6/BAK1/GADD45G/GADD45B/CDK4	27
KEGG	hsa04926	Relaxin signaling pathway	43/1853	129/8135	0.003738	0.08802	0.07018	ADCY8/SHC2/PLCB4/PLCB1/SHC3/MAPK3/EGFR/RXFP1/MAPK1/PIK3CB/MAPK10/KRAS/GNG12/JUN/EDNRB/COL4A1/ADCY4/PRKACB/RXFP3/CREB1/COL4A5/GNAI1/SMAD2/TGFBR2/ARRB1/MMP9/EDN1/TGFBR1/PLCB2/RXFP4/MAP2K1/SRC/ADCY3/NOS3/MMP1/ARRB2/GNG2/CREB3L4/GNB4/CREB3L3/INSL3/MAPK9/MAPK8	43
KEGG	hsa04115	p53 signaling pathway	27/1853	73/8135	0.004131	0.08802	0.07018	THBS1/RPRM/CYCS/CDK2/STEAP3/CCNG1/SESN3/CCNE1/ATR/CDK6/CCNE2/EI24/PTEN/CCNB1/CHEK2/BCL2/GADD45G/CASP9/CCNG2/CASP3/SFN/CD82/RRM2/GADD45B/CCND2/CDK4/PMAIP1	27
KEGG	hsa04668	TNF signaling pathway	38/1853	112/8135	0.00443	0.08802	0.07018	IL6/RPS6KA5/IRF1/MAP2K6/CXCL6/TNFRSF1B/IL18R1/MAPK3/MAPK1/PIK3CB/MAPK10/MLKL/CXCL2/MAP3K8/JUN/NOD2/CXCL1/CREB1/CSF2/MMP9/EDN1/CSF1/CASP10/IL1B/RIPK3/MAP2K1/CASP3/CREB3L4/CXCL5/MMP3/CXCL10/BCL3/CREB3L3/FADD/BAG4/DNM1L/MAPK9/MAPK8	38
KEGG	hsa04720	Long-term potentiation	25/1853	67/8135	0.004967	0.08802	0.07018	ADCY8/GRIN2A/PLCB4/PLCB1/MAPK3/RPS6KA6/MAPK1/GRIA1/GRM1/KRAS/GRIN2C/RAP1A/PRKACB/PPP3CB/PPP1R1A/PPP1CB/ARAF/GNAQ/PPP1CC/PLCB2/CAMK4/GRM5/MAP2K1/RPS6KA3/PPP3R2	25
KEGG	hsa05142	Chagas disease	35/1853	102/8135	0.005029	0.08802	0.07018	IL6/PLCB4/PPP2R2B/PLCB1/IL12A/MAPK3/ACE/IL10/MAPK1/PPP2R2A/PIK3CB/MAPK10/KNG1/JUN/TGFB3/GNA14/PPP2CB/GNAI1/TLR6/SMAD2/TGFBR2/GNAQ/TGFBR1/CD247/IL12B/IL1B/PLCB2/C1QC/MYD88/PPP2R1A/C1QB/FADD/TLR2/MAPK9/MAPK8	35
KEGG	hsa04068	FoxO signaling pathway	43/1853	131/8135	0.005118	0.08802	0.07018	S1PR1/IL6/IL7R/MAPK3/EGFR/IL10/MAPK1/TNFSF10/PIK3CB/CDK2/MAPK10/G6PC3/GRM1/PRKAA2/CAT/KRAS/TGFB3/PLK4/PLK1/CCNB3/TGFBR2/ARAF/PTEN/CCNB1/SKP2/TGFBR1/PRKAB1/MAP2K1/STK11/HOMER1/S1PR4/PRKAG1/GADD45G/CCNG2/SOD2/PRKAB2/PLK3/FOXO3/GADD45B/SMAD4/CCND2/MAPK9/MAPK8	43
KEGG	hsa05225	Hepatocellular carcinoma	53/1853	168/8135	0.005162	0.08802	0.07018	HGF/SHC2/WNT9A/SMARCD2/WNT16/WNT11/SHC3/MAPK3/DVL2/WNT10B/GSTT1/WNT2/EGFR/MAPK1/PIK3CB/GSTA4/APC/ELK1/TCF7/DPF1/KRAS/SMARCE1/TGFB3/GSTM4/AXIN1/KEAP1/CDK6/SMAD2/DPF3/TGFBR2/ARAF/WNT4/FRAT1/PTEN/FZD1/GSTM5/GSTM3/FZD8/TXNRD3/TGFBR1/GSTA2/MAP2K1/SMARCD3/BAK1/GSTT2/GADD45G/GAB1/APC2/PHF10/WNT1/GADD45B/SMAD4/CDK4	53
KEGG	hsa04024	cAMP signaling pathway	67/1853	221/8135	0.00527	0.08802	0.07018	ADCY8/PDE3B/GRIN2A/PLD1/ADORA1/ATP1A2/CNGA3/NPR1/MAPK3/ADRB2/PAK1/GRIA3/PTGER2/MAPK1/SSTR1/PIK3CB/GRIN3A/GRIA1/CHRM1/MAPK10/CHRM2/MC2R/GIP/GRIN2C/JUN/ATP1A3/ROCK1/PLCE1/RAP1A/BDNF/ADCY4/PRKACB/CREB1/EDNRA/ATP1B1/FXYD1/GNAI1/PPP1CB/PDE4D/DRD2/EDN1/PPP1CC/GABBR2/OXTR/FFAR2/CAMK4/ATP2B3/MAP2K1/ADCY3/ACOX3/ADORA2A/HTR1A/CRHR2/HTR1B/ATP2B2/NPY1R/PDE4C/CREB3L4/GPR119/FXYD2/CREB3L3/GPHA2/SST/RRAS2/PDE3A/MAPK9/MAPK8	67
KEGG	hsa04380	Osteoclast differentiation	42/1853	128/8135	0.005658	0.08949	0.07136	CSF1R/MAP2K6/TNFRSF11A/MAPK3/IL1R1/MAPK1/PIK3CB/MITF/MAPK10/TEC/TREM2/PPARG/JUN/NCF2/CREB1/PPP3CB/TGFBR2/NOX1/FOSL1/LCK/GAB2/CSF1/LILRB3/TGFBR1/FCGR2B/OSCAR/IL1B/CAMK4/MAP2K1/LILRA1/SIRPA/TYROBP/PPP3R2/FCGR2A/SIRPG/TNFRSF11B/ITGB3/NCF4/ACP5/MAPK9/SPI1/MAPK8	42
KEGG	hsa04530	Tight junction	53/1853	169/8135	0.005895	0.08949	0.07136	PARD6B/CLDN4/PPP2R2B/RAB8A/PARD6A/MYH10/PPP2R2A/ARHGEF18/MARVELD2/MAPK10/TJP1/CLDN9/TJP2/LLGL2/CGNL1/PRKAA2/PRKCE/MSN/CRB3/CLDN23/VASP/JUN/MPP4/ROCK1/ACTN1/RAP1A/PRKACB/PPP2CB/OCLN/MYH11/MYL6B/PRKAB1/ERBB2/CGN/CLDN17/SRC/CLDN19/CLDN7/STK11/PRKAG1/CLDN22/MAGI1/PRKAB2/CLDN6/SYNPO/CLDN11/JAM2/PPP2R1A/CDK4/PARD6G/MAPK9/MICALL2/MAPK8	53
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	34/1853	100/8135	0.006621	0.09615	0.07667	IL6/PLCB4/PLCB1/AGTR1/MAPK3/MAPK1/F3/PIK3CB/MAPK10/PRKCE/AGER/KRAS/JUN/TGFB3/PLCE1/COL4A1/STAT5A/COL4A5/PLCD3/SMAD2/TGFBR2/NOX1/EDN1/PRKCD/TGFBR1/IL1B/PLCB2/NOS3/BCL2/CASP3/SMAD4/CDK4/MAPK9/MAPK8	34
KEGG	hsa05210	Colorectal cancer	30/1853	86/8135	0.006919	0.09629	0.07678	MAPK3/CYCS/EGFR/MAPK1/PIK3CB/APC/MAPK10/TCF7/KRAS/JUN/TGFB3/AXIN1/SMAD2/TGFBR2/ARAF/TGFBR1/AREG/MAP2K1/BCL2/BAK1/GADD45G/CASP9/RALB/CASP3/APC2/GADD45B/SMAD4/MAPK9/PMAIP1/MAPK8	30
KEGG	hsa04916	Melanogenesis	34/1853	101/8135	0.007848	0.09667	0.07708	ADCY8/WNT9A/PLCB4/PLCB1/WNT16/WNT11/MAPK3/DVL2/WNT10B/WNT2/MAPK1/MITF/TCF7/KRAS/MC1R/KITLG/EDNRB/ADCY4/PRKACB/CREB1/GNAI1/WNT4/EDN1/GNAQ/FZD1/FZD8/PLCB2/MAP2K1/ADCY3/CREB3L4/KIT/WNT1/CREB3L3/ASIP	34
KEGG	hsa04270	Vascular smooth muscle contraction	43/1853	134/8135	0.007985	0.09667	0.07708	ADCY8/GUCY1A2/RAMP2/PPP1R12B/PLCB4/PLCB1/AGTR1/NPR1/MAPK3/PLA2G4F/MYH10/MAPK1/PTGIR/KCNMB1/PPP1R14A/PRKCE/ADORA2B/CALD1/PLA2G4A/ROCK1/ADCY4/PRKACB/EDNRA/JMJD7-PLA2G4B/PPP1CB/ARAF/NPPB/EDN1/GNAQ/MYH11/MYL6B/PPP1CC/PRKCD/PLCB2/MAP2K1/ADCY3/ADORA2A/ADRA1B/CALCRL/CALCA/PRKG1/PLA2G2D/ACTG2	43
KEGG	hsa04350	TGF-beta signaling pathway	32/1853	94/8135	0.008104	0.09667	0.07708	THBS1/BMP7/MAPK3/MAPK1/INHBA/TFDP1/SMAD9/ACVR1C/RGMA/SMAD6/RBL1/LEFTY1/TGFB3/ROCK1/GDF6/GREM1/PPP2CB/TGIF1/BMP4/SMAD2/TGFBR2/NOG/FST/TGFBR1/PPP2R1A/ACVR1B/SMAD4/BMP6/ID4/E2F4/AMHR2/NEO1	32
KEGG	hsa04657	IL-17 signaling pathway	32/1853	94/8135	0.008104	0.09667	0.07708	IL6/CXCL6/MAPK3/TRAF3IP2/MAPK1/IL17RA/MAPK10/CXCL2/USP25/IL17F/JUN/CXCL1/IL4/IL17D/IKBKE/CSF2/FOSL1/MMP9/IL17A/IL1B/MMP1/CSF3/CASP3/CXCL5/MMP3/CXCL10/IL17RB/IL17B/FADD/S100A7/MAPK9/MAPK8	32
KEGG	hsa00562	Inositol phosphate metabolism	26/1853	73/8135	0.008502	0.09792	0.07808	PLCB4/PLCB1/INPP5J/PIK3CB/PLCH2/SYNJ2/MTMR4/INPP5E/IMPA2/MTMR14/CDIPT/INPP1/FIG4/PLCE1/PLCD3/PI4KB/PTEN/PI4KA/PLCB2/ALDH6A1/IPMK/OCRL/MTMR8/ITPKB/PIP5KL1/PLCH1	26
KEGG	hsa04730	Long-term depression	22/1853	60/8135	0.01023	0.1138	0.09078	GUCY1A2/PLCB4/PLCB1/MAPK3/PLA2G4F/GRIA3/MAPK1/GRIA1/GRM1/KRAS/PLA2G4A/PPP2CB/JMJD7-PLA2G4B/GNAI1/GRID2/ARAF/GNAQ/PLCB2/MAP2K1/PRKG2/PRKG1/PPP2R1A	22
KEGG	hsa01232	Nucleotide metabolism	29/1853	85/8135	0.01099	0.1169	0.09322	UPP1/AK7/NME7/NT5E/AK3/CTPS2/ENPP3/AK5/CANT1/ENPP1/ADK/NUDT16/TYMP/AMPD3/ENTPD6/GMPR/GMPS/UCK1/XDH/DGUOK/NT5C/ASMTL/UCKL1/HPRT1/UPP2/RRM2/ADSL/IMPDH2/GMPR2	29
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	15/1853	37/8135	0.01169	0.1169	0.09322	CPS1/ABAT/ASPA/GLUL/GLUD2/PPAT/GLS/DDO/GAD1/GFPT1/GLUD1/ADSL/GFPT2/ASNS/ASRGL1	15
KEGG	hsa05143	African trypanosomiasis	15/1853	37/8135	0.01169	0.1169	0.09322	IL6/PLCB4/PLCB1/IDO1/IL12A/IL10/APOA1/KNG1/F2RL1/GNAQ/IL12B/IL1B/PLCB2/MYD88/IDO2	15
KEGG	hsa04060	Cytokine-cytokine receptor interaction	84/1853	295/8135	0.0119	0.1169	0.09322	IL6/IL7R/PF4V1/TNFSF15/BMP7/TNFRSF21/CSF1R/CXCL6/TNFRSF1B/IL18R1/IL12RB1/TNFRSF11A/IL12A/IL33/TNFSF13B/IL1R1/IL10/IL17RA/TNFSF10/CSF2RB/IL27RA/IL7/BMP10/CCL21/CNTFR/INHBA/ACVR1C/CXCL2/TNFSF8/CX3CR1/CCR1/MPL/IL3RA/IL17F/TNFRSF17/TGFB3/CTF1/IL11RA/CXCL1/GDF6/IL6R/IL4/IL17D/IL21/BMP15/CSF2/EPOR/BMP4/CD70/TGFBR2/ACVRL1/CSF1/IL17A/IL19/TGFBR1/CCL18/IL12B/IL1B/CD40/CRLF2/CCL15/TSLP/IL16/XCR1/CSF3/CSF3R/IL26/CXCL5/IFNW1/CXCL10/TNFRSF11B/IL17RB/CCL4/ACVR1B/LEPR/TNFRSF10C/BMP6/IL17B/IL32/IL20RA/GDF10/CD40LG/AMHR2/TNFRSF14	84
KEGG	hsa05323	Rheumatoid arthritis	31/1853	93/8135	0.01257	0.12	0.09567	ATP6V0E2/IL6/ITGB2/CXCL6/TNFRSF11A/TNFSF13B/TCIRG1/HLA-DQA1/ATP6V1E2/CXCL2/ATP6V1G3/JUN/TGFB3/CXCL1/CTLA4/HLA-DQA2/CSF2/CSF1/IL17A/ATP6AP1/HLA-DOA/IL1B/MMP1/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1/CXCL5/MMP3/TLR2/ACP5	31
KEGG	hsa05133	Pertussis	26/1853	76/8135	0.01495	0.1318	0.1051	IL6/ITGB2/C5/IRF1/CXCL6/IL12A/MAPK3/IL10/MAPK1/PYCARD/MAPK10/SERPING1/JUN/C2/GNAI1/IL12B/IL1B/NLRP3/C1QC/MYD88/CASP3/CXCL5/C4BPB/C1QB/MAPK9/MAPK8	26
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	46/1853	150/8135	0.01502	0.1318	0.1051	ADCY8/RPS6KA5/PLCB4/PPP2R2B/PLCB1/AGTR1/ATP1A2/SLC8A1/MAPK3/ADRB2/MAPK1/PPP2R2A/PIK3R6/CACNB2/CACNG4/ATP1A3/ADCY4/PRKACB/PPP2CB/CREB1/ATP1B1/GNAI1/PPP1R1A/SCN5A/PPP1CB/GNAQ/PPP1CC/CACNA2D3/PIK3R5/PLCB2/ATP2B3/TPM3/CACNA2D1/ADCY3/ADRA1B/BCL2/TNNT2/ACTC1/CACNG5/ATP2B2/MYH7/PPP2R5D/CREB3L4/FXYD2/CREB3L3/PPP2R1A	46
KEGG	hsa04925	Aldosterone synthesis and secretion	32/1853	98/8135	0.01558	0.1318	0.1051	ADCY8/PLCB4/PLCB1/AGTR1/ATP1A2/NPR1/KCNJ5/CAMK1/CACNA1H/MC2R/LDLR/PRKCE/CAMK1G/ATP1A3/ATF1/ADCY4/PRKACB/CREB1/ATP1B1/GNAQ/PLCB2/CAMK4/ATP2B3/PRKD1/ADCY3/STAR/ATP2B2/CREB3L4/CREB3L3/PDE2A/SCARB1/NR4A2	32
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/1853	143/8135	0.01613	0.1318	0.1051	WNT9A/FGFR2/WNT16/WNT11/MAPK3/DVL2/WNT10B/SOX2/WNT2/KLF4/MAPK1/HESX1/PIK3CB/INHBA/APC/SMAD9/ACVR1C/LEFTY1/HAND1/TCF7/FGF2/SETDB1/KRAS/MEIS1/AXIN1/ONECUT1/BMP4/SMAD2/TBX3/WNT4/FZD1/FZD8/HOXA1/FGFR4/FGFR1/HOXD1/ESRRB/MAP2K1/POU5F1/APC2/WNT1/ACVR1B/SMAD4/ID4	44
KEGG	hsa00230	Purine metabolism	40/1853	128/8135	0.01627	0.1318	0.1051	ADCY8/GUCY1A2/PDE3B/PDE7B/AK7/NME7/NPR1/PDE1B/NT5E/AK3/NUDT2/ENPP3/PPAT/AK5/CANT1/ENPP1/ADK/NUDT16/ADCY4/AMPD3/PAICS/PDE4D/PDE6G/ENTPD6/GMPR/GMPS/ADCY3/XDH/DGUOK/NT5C/HPRT1/PDE4C/PFAS/RRM2/PDE7A/ADSL/PDE3A/PDE2A/IMPDH2/GMPR2	40
KEGG	hsa05224	Breast cancer	45/1853	147/8135	0.01655	0.1318	0.1051	FGF16/SHC2/WNT9A/FGF18/WNT16/WNT11/SHC3/MAPK3/DVL2/WNT10B/WNT2/EGFR/MAPK1/PIK3CB/APC/FGF1/FGF7/FGF10/TCF7/PGR/FGF2/KRAS/JUN/AXIN1/CDK6/FGF17/ARAF/WNT4/FGF8/FRAT1/PTEN/FZD1/FZD8/FGFR1/ERBB2/BRCA1/MAP2K1/FGF6/BAK1/GADD45G/KIT/APC2/WNT1/GADD45B/CDK4	45
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	34/1853	106/8135	0.01712	0.1318	0.1051	ADCY8/PLD1/PLCB4/PLCB1/MAPK3/EGFR/MAPK1/GCM1/KL/MAFB/ADCY4/PRKACB/CREB1/GNAI1/SOST/ARAF/PDE4D/ARRB1/GNAQ/FGFR1/PLCB2/MAP2K1/ADCY3/SLC34A1/BCL2/ARRB2/PDE4C/CREB3L4/PTHLH/CREB3L3/VDR/TRPV5/SLC34A2/NR4A2	34
KEGG	hsa04934	Cushing syndrome	47/1853	155/8135	0.01736	0.1318	0.1051	ADCY8/PBX1/WNT9A/PLCB4/PLCB1/AGTR1/WNT16/WNT11/MAPK3/DVL2/WNT10B/WNT2/EGFR/MAPK1/CDK2/APC/CACNA1H/MC2R/LDLR/TCF7/CCNE1/RAP1A/AXIN1/ADCY4/PRKACB/CREB1/GNAI1/CDK6/CCNE2/WNT4/GNAQ/FZD1/FZD8/ASH2L/PLCB2/MAP2K1/CYP17A1/ADCY3/CRHR2/STAR/CREB3L4/APC2/MRAP/WNT1/CREB3L3/CDK4/SCARB1	47
KEGG	hsa00380	Tryptophan metabolism	16/1853	42/8135	0.01807	0.1318	0.1051	IDO1/ALDH3A2/HADH/ALDH1B1/AOX1/CAT/ASMT/CYP1A2/HADHA/ALDH9A1/MAOB/ALDH8A1/ALDH2/INMT/IDO2/ACAT2	16
KEGG	hsa04640	Hematopoietic cell lineage	32/1853	99/8135	0.01813	0.1318	0.1051	CD34/IL6/IL7R/CD55/CSF1R/IL1R1/ITGA2/IL7/FLT3LG/HLA-DQA1/IL3RA/KITLG/IL11RA/IL6R/ANPEP/IL4/FCER2/HLA-DQA2/CSF2/MME/EPOR/CSF1/HLA-DOA/IL1B/CD7/CSF3/CSF3R/KIT/CD38/CD5/ITGB3/CD37	32
KEGG	hsa04540	Gap junction	29/1853	88/8135	0.01816	0.1318	0.1051	ADCY8/GUCY1A2/HTR2A/PLCB4/PLCB1/PDGFA/MAPK3/MAP2K5/EGFR/MAPK1/TJP1/GRM1/KRAS/ADCY4/HTR2B/PRKACB/PDGFB/GNAI1/DRD2/GNAQ/LPAR1/TUBB1/PLCB2/GRM5/MAP2K1/SRC/ADCY3/PRKG2/PRKG1	29
KEGG	hsa04218	Cellular senescence	47/1853	156/8135	0.01951	0.1385	0.1105	IL6/CCNA1/RASSF5/MRAS/MAP2K6/MAPK3/TRAF3IP2/MAPK1/HIPK4/PIK3CB/RAD9B/CDK2/RBBP4/RBL1/ETS1/KRAS/CCNA2/FOXM1/TGFB3/CCNE1/NFATC4/CCNB3/PPP3CB/ATR/CDK6/SMAD2/TGFBR2/CCNE2/PPP1CB/PTEN/PPP1CC/CCNB1/TGFBR1/CHEK2/MAP2K1/HIPK3/GADD45G/PPP3R2/VDAC3/LIN54/RRAS2/FOXO3/GADD45B/E2F4/CCND2/KIR2DL4/CDK4	47
KEGG	hsa04080	Neuroactive ligand-receptor interaction	97/1853	353/8135	0.01991	0.1385	0.1105	S1PR1/GRIN2A/C5/HTR2A/ADORA1/AGTR1/ADRA2A/ADRB2/P2RX7/GRIA3/THRB/LYPD6B/RXFP1/PTGER2/PTGIR/SSTR1/GRIN3A/GRIA1/CHRM1/PATE1/NMB/GLP2R/PENK/CHRM2/MC2R/HRH3/GRM1/GABRR3/PTGFR/ADORA2B/KNG1/GLRB/GIP/LPAR4/MC1R/GRIN2C/EDNRB/F2RL2/NTSR2/CHRNG/SCT/HRH4/HTR2B/GABRR1/MLNR/RXFP3/PMCH/GHRHR/EDNRA/GRID2/F2RL1/PRSS3/DRD2/PRSS2/OPRM1/EDN1/CHRM4/GABBR2/ADRA2B/UTS2/CTSG/LPAR1/OXTR/DRD4/MC3R/P2RX2/UCN3/C5AR1/GRM5/RXFP4/MLN/GCGR/GABRQ/NMUR2/CHRNA2/ADORA2A/HTR1A/ADRA1B/CALCRL/CRHR2/HTR1B/S1PR4/P2RX4/NPY1R/GHRH/TRHR/CALCA/P2RY2/GPHA2/SST/GALR2/INSL3/CHRNB2/LEPR/CHRNA7/CCK/TAAR2	97
KEGG	hsa04625	C-type lectin receptor signaling pathway	33/1853	104/8135	0.02187	0.1422	0.1134	IL6/IRF1/MRAS/CARD9/IL12A/MAPK3/PAK1/IL10/MAPK1/PIK3CB/EGR3/PYCARD/MAPK10/KRAS/JUN/IL17D/IKBKE/NFATC4/PPP3CB/PRKCD/IL12B/IL1B/SRC/NLRP3/CLEC4M/PPP3R2/PLK3/BCL3/CLEC4D/LSP1/RRAS2/MAPK9/MAPK8	33
KEGG	hsa04071	Sphingolipid signaling pathway	37/1853	119/8135	0.02194	0.1422	0.1134	S1PR1/SPTLC3/PLD1/PLCB4/PPP2R2B/ADORA1/PLCB1/MAPK3/MAPK1/PPP2R2A/PIK3CB/MAPK10/PRKCE/SGPL1/KNG1/KRAS/ROCK1/SPHK2/SMPD1/PPP2CB/ABCC1/GNAI1/ACER1/GNAQ/GAB2/PTEN/PLCB2/MAP2K1/NOS3/BCL2/S1PR4/PPP2R5D/DEGS1/SGMS2/PPP2R1A/MAPK9/MAPK8	37
KEGG	hsa04614	Renin-angiotensin system	10/1853	23/8135	0.022	0.1422	0.1134	AGTR1/ACE/REN/ANPEP/MME/CMA1/CTSG/PREP/ENPEP/KLK2	10
KEGG	hsa04915	Estrogen signaling pathway	42/1853	138/8135	0.02215	0.1422	0.1134	ADCY8/SHC2/PLCB4/PLCB1/KRT24/SHC3/MAPK3/EGFR/MAPK1/PIK3CB/KCNJ5/NCOA2/KRT34/GRM1/PGR/KRAS/JUN/ADCY4/PRKACB/CREB1/KRT31/GNAI1/KCNJ6/HSPA6/KRT23/KRT18/MMP9/OPRM1/GNAQ/GABBR2/PRKCD/PLCB2/KRT13/MAP2K1/SRC/ADCY3/NOS3/BCL2/KRT33B/KRT33A/CREB3L4/CREB3L3	42
KEGG	hsa04936	Alcoholic liver disease	43/1853	142/8135	0.02265	0.1428	0.1138	IL6/C5/ADH1A/PPARGC1A/MAP2K6/ALDH3A2/IL12A/ADH1C/IL17RA/ALDH1B1/LPIN1/MAPK10/PRKAA2/TCF7/CXCL2/ADH5/CXCL1/CAMKK2/ADIPOQ/C2/CPT1C/IKBKE/ALDH9A1/IL17A/ACACB/PRKAB1/IL12B/IL1B/C5AR1/ACOX3/C1QC/ALDH2/ADH4/PRKAG1/MYD88/PRKAB2/CASP3/TRA2A/FOXO3/C1QB/FADD/MAPK9/MAPK8	43
KEGG	hsa04911	Insulin secretion	28/1853	86/8135	0.02355	0.1457	0.1162	ADCY8/PLCB4/PLCB1/ATP1A2/KCNMB1/STX1A/PCLO/GIP/ATP1A3/KCNN2/ADCY4/PRKACB/CREB1/ATP1B1/GNAQ/PLCB2/PDX1/ADCY3/KCNN1/SNAP25/ABCC8/CREB3L4/KCNN3/GPR119/FXYD2/CREB3L3/KCNN4/CCK	28
KEGG	hsa04014	Ras signaling pathway	66/1853	232/8135	0.02422	0.1471	0.1173	HGF/FGF16/GRIN2A/NTF3/SHC2/PLD1/FGF18/FGFR2/RASA3/CSF1R/RASSF5/MRAS/PDGFA/SHC3/MAPK3/PAK1/PLA2G4F/EGFR/MAPK1/RASAL2/PIK3CB/MAPK10/FGF1/FLT3LG/PAK2/FGF7/ELK1/FGF10/FGF2/ETS1/KRAS/PLA2G4A/GNG12/KITLG/PLCE1/RAP1A/RASA4/BDNF/PRKACB/RASGRP1/PDGFB/JMJD7-PLA2G4B/FGF17/GAB2/FGF8/CSF1/FGFR4/FGFR1/MAP2K1/RASGRF1/ABL2/RAB5C/FGF6/RAPGEF5/GAB1/RALB/GNG2/RASGRP2/KIT/GNB4/PGF/RRAS2/PLA2G2D/MAPK9/EPHA2/MAPK8	66
KEGG	hsa05321	Inflammatory bowel disease	22/1853	65/8135	0.02708	0.1615	0.1288	TLR5/IL6/IL18R1/IL12RB1/IL12A/IL10/HLA-DQA1/IL17F/JUN/NOD2/TGFB3/IL4/IL21/HLA-DQA2/SMAD2/FOXP3/IL17A/HLA-DOA/IL12B/IL1B/STAT4/TLR2	22
KEGG	hsa05213	Endometrial cancer	20/1853	58/8135	0.02795	0.1638	0.1306	MAPK3/EGFR/MAPK1/PIK3CB/APC/ELK1/TCF7/KRAS/AXIN1/ARAF/PTEN/ERBB2/CTNNA3/MAP2K1/BAK1/GADD45G/CASP9/APC2/FOXO3/GADD45B	20
KEGG	hsa04724	Glutamatergic synapse	35/1853	114/8135	0.03044	0.1733	0.1382	ADCY8/GRIN2A/PLD1/PLCB4/PLCB1/MAPK3/PLA2G4F/GRIA3/GLUL/MAPK1/GRIN3A/GRIA1/GRM1/SLC1A3/GLS/PLA2G4A/GNG12/DLGAP1/GRIN2C/SLC1A1/ADCY4/PRKACB/JMJD7-PLA2G4B/PPP3CB/GNAI1/DLG4/GNAQ/PLCB2/GRM5/ADCY3/HOMER1/GNG2/PPP3R2/SLC1A2/GNB4	35
KEGG	hsa01524	Platinum drug resistance	24/1853	73/8135	0.03062	0.1733	0.1382	MAPK3/GSTT1/CYCS/MAPK1/ATP7B/PIK3CB/GSTA4/TOP2A/REV3L/GSTM4/GSTM5/GSTM3/ERBB2/GSTA2/BRCA1/XPA/BCL2/BAK1/GSTT2/CASP9/CASP3/FADD/PMAIP1/ABCC2	24
KEGG	hsa04974	Protein digestion and absorption	32/1853	103/8135	0.03179	0.1769	0.1411	DPP4/COL9A3/KCNK5/COL8A1/COL10A1/ATP1A2/SLC8A1/COL17A1/COL11A1/SLC36A1/ATP1A3/SLC1A1/CTRL/KCNE3/COL4A1/COL4A5/ATP1B1/MME/SLC7A7/MEP1A/PRSS3/PRSS2/SLC36A3/COL20A1/ELN/COL5A2/CPB1/COL5A3/KCNJ13/FXYD2/KCNN4/COL22A1	32
KEGG	hsa04110	Cell cycle	38/1853	126/8135	0.03266	0.1769	0.1411	CCNA1/TFDP2/CDK2/TFDP1/WEE1/RBL1/CCNA2/TGFB3/CCNE1/CDC25B/PLK1/CCNB3/TTK/ATR/SMC1B/CDK6/SMAD2/CCNE2/CCNB1/SKP2/CHEK2/PTTG2/DBF4/YWHAG/CDC14B/CDC25C/HDAC1/BUB1B/GADD45G/SFN/GADD45B/SMAD4/CDC6/MAD2L1/E2F4/CCND2/CDK4/BUB1	38
KEGG	hsa04390	Hippo signaling pathway	46/1853	157/8135	0.03325	0.1769	0.1411	PARD6B/ITGB2/WNT9A/PPP2R2B/BMP7/WNT16/PARD6A/WNT11/DVL2/WNT10B/SOX2/WNT2/PPP2R2A/TEAD1/APC/FGF1/CRB1/LLGL2/TCF7/TGFB3/GDF6/AXIN1/PPP2CB/DLG4/BMP4/SMAD2/TGFBR2/PPP1CB/WNT4/FZD1/PPP1CC/FZD8/TGFBR1/YWHAG/AREG/CTNNA3/WWTR1/YAP1/APC2/LATS2/WNT1/PPP2R1A/SMAD4/BMP6/CCND2/PARD6G	46
KEGG	hsa00410	beta-Alanine metabolism	12/1853	31/8135	0.03359	0.1769	0.1411	ABAT/ALDH3A2/ALDH1B1/ACADS/HADHA/ALDH9A1/GAD1/ALDH6A1/ACOX3/ALDH2/ALDH3A1/CNDP1	12
KEGG	hsa04012	ErbB signaling pathway	27/1853	85/8135	0.03519	0.1769	0.1411	SHC2/BTC/SHC3/MAPK3/PAK1/EGFR/MAPK1/PIK3CB/MAPK10/PAK2/ELK1/NCK1/KRAS/JUN/STAT5A/ARAF/ERBB4/ERBB2/AREG/MAP2K1/ABL2/SRC/GAB1/CRKL/NRG1/MAPK9/MAPK8	27
KEGG	hsa04610	Complement and coagulation cascades	27/1853	85/8135	0.03519	0.1769	0.1411	MASP1/ITGB2/C5/CD55/CFB/F3/F10/F13A1/C9/SERPING1/KNG1/F2RL2/C2/F5/F8/F12/SERPIND1/CFD/SERPINB2/CFHR1/C5AR1/C1QC/CD46/C4BPB/CFH/C1QB/CFHR3	27
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/1853	15/8135	0.03549	0.1769	0.1411	B3GALT5/A4GALT/NAGA/B3GALNT1/FUT1/ST8SIA1/HEXA	7
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/1853	15/8135	0.03549	0.1769	0.1411	ST6GALNAC5/ST3GAL5/B4GALNT1/ST6GALNAC4/ST6GALNAC6/ST8SIA1/HEXA	7
KEGG	hsa05030	Cocaine addiction	17/1853	49/8135	0.03849	0.189	0.1507	GRIN2A/RGS9/GRIN3A/GRIN2C/JUN/BDNF/PRKACB/CREB1/GNAI1/DLG4/DRD2/MAOB/CDK5R1/SLC18A2/GPSM1/CREB3L4/CREB3L3	17
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	18/1853	53/8135	0.04156	0.1984	0.1582	DNM1/PLCB4/PLCB1/ATP1A2/SLC8A1/KL/CLTCL1/ATP1A3/PRKACB/ATP1B1/GNAQ/PLCB2/ATP2B3/ATP2B2/FXYD2/VDR/TRPV5/KLK2	18
KEGG	hsa05410	Hypertrophic cardiomyopathy	28/1853	90/8135	0.04187	0.1984	0.1582	IL6/ITGB8/SLC8A1/ACE/ITGA2/TTN/PRKAA2/SGCD/CACNB2/CACNG4/TGFB3/EDN1/DMD/ITGA9/PRKAB1/EMD/CACNA2D3/TPM3/CACNA2D1/TNNT2/ACTC1/CACNG5/MYH7/PRKAG1/PRKAB2/ITGA8/ITGA10/ITGB3	28
KEGG	hsa04929	GnRH secretion	21/1853	64/8135	0.04217	0.1984	0.1582	PLCB4/PLCB1/MAPK3/MAPK1/PIK3CB/KCNJ5/CACNA1H/KRAS/KCNN2/SPP1/KCNJ6/ARRB1/GNAQ/GABBR2/PLCB2/MAP2K1/ARRB2/KCNN1/KCNN3/HCN1/KCNN4	21
KEGG	hsa04725	Cholinergic synapse	34/1853	113/8135	0.0429	0.199	0.1587	ADCY8/PLCB4/PLCB1/MAPK3/CHAT/MAPK1/PIK3CB/CHRM1/KCNJ2/CHRM2/PIK3R6/KRAS/GNG12/ADCY4/PRKACB/CREB1/GNAI1/KCNQ4/KCNJ6/KCNQ3/GNAQ/CHRM4/PIK3R5/PLCB2/CAMK4/MAP2K1/ADCY3/BCL2/GNG2/CREB3L4/GNB4/CREB3L3/CHRNB2/CHRNA7	34
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	30/1853	98/8135	0.0443	0.201	0.1603	ADCY8/HTR2A/PLCB4/PLCB1/CYP2J2/MAP2K6/PLA2G4F/IL1R1/PTGER2/PIK3CB/MAPK10/PRKCE/KNG1/PLA2G4A/ADCY4/HTR2B/PRKACB/JMJD7-PLA2G4B/PPP1CB/F2RL1/GNAQ/PPP1CC/PRKCD/IL1B/PLCB2/SRC/ADCY3/P2RY2/MAPK9/MAPK8	30
KEGG	hsa04914	Progesterone-mediated oocyte maturation	31/1853	102/8135	0.04539	0.201	0.1603	ADCY8/PDE3B/CCNA1/MAPK3/RPS6KA6/MAPK1/PIK3CB/CDK2/CPEB1/MAPK10/PGR/KRAS/CCNA2/CDC25B/ADCY4/PRKACB/AURKA/PLK1/CCNB3/GNAI1/ARAF/CCNB1/CPEB2/CDC25C/MAP2K1/ADCY3/RPS6KA3/MAD2L1/MAPK9/MAPK8/BUB1	31
KEGG	hsa05146	Amoebiasis	31/1853	102/8135	0.04539	0.201	0.1603	LAMA3/IL6/ITGB2/PLCB4/PLCB1/IL12A/IL1R1/IL10/PIK3CB/LAMC2/CXCL2/C9/RAB7B/TGFB3/GNA14/CXCL1/ACTN1/COL4A1/PRKACB/COL4A5/CSF2/GNAQ/CTSG/SERPINB6/IL12B/IL1B/PLCB2/RAB5C/LAMB3/CASP3/TLR2	31
KEGG	hsa04979	Cholesterol metabolism	17/1853	50/8135	0.04634	0.201	0.1603	CYP27A1/SOAT2/APOA4/LPA/CYP7A1/LIPC/APOA1/LDLR/APOE/SOAT1/LIPG/STAR/STARD3/MYLIP/VDAC3/ABCA1/SCARB1	17
KEGG	hsa00982	Drug metabolism - cytochrome P450	23/1853	72/8135	0.04635	0.201	0.1603	CYP3A5/ADH1A/ADH1C/CYP3A4/GSTT1/GSTA4/AOX1/FMO3/ADH5/FMO5/CYP1A2/GSTM4/CYP2A7/GSTM5/GSTM3/FMO4/CYP2D6/MAOB/GSTA2/CYP2C8/ALDH3A1/GSTT2/ADH4	23
KEGG	hsa05212	Pancreatic cancer	24/1853	76/8135	0.0482	0.2041	0.1628	PLD1/MAPK3/EGFR/MAPK1/PIK3CB/MAPK10/KRAS/TGFB3/CDK6/SMAD2/TGFBR2/ARAF/TGFBR1/ERBB2/MAP2K1/BAK1/GADD45G/CASP9/RALB/GADD45B/SMAD4/CDK4/MAPK9/MAPK8	24
KEGG	hsa05160	Hepatitis C	45/1853	157/8135	0.04921	0.2041	0.1628	CLDN4/PPP2R2B/MAPK3/RSAD2/CYCS/EGFR/MAPK1/PPP2R2A/OAS2/PIK3CB/CDK2/CLDN9/OAS1/LDLR/CLDN23/KRAS/PPP2CB/MX1/IKBKE/CDK6/OCLN/ARAF/TLR3/EIF2AK1/YWHAG/CLDN17/MAP2K1/EIF2AK2/CLDN19/RNASEL/OAS3/CLDN7/BAK1/CASP9/CLDN22/CASP3/CLDN6/CXCL10/CLDN11/IFIT1/PPP2R1A/FADD/MX2/CDK4/SCARB1	45
KEGG	hsa04927	Cortisol synthesis and secretion	21/1853	65/8135	0.04937	0.2041	0.1628	ADCY8/PBX1/NR0B1/PLCB4/PLCB1/AGTR1/CACNA1H/MC2R/LDLR/ADCY4/PRKACB/CREB1/GNAQ/PLCB2/CYP17A1/ADCY3/STAR/CREB3L4/MRAP/CREB3L3/SCARB1	21
KEGG	hsa04151	PI3K-Akt signaling pathway	94/1853	354/8135	0.04951	0.2041	0.1628	HGF/THBS1/FGF16/LAMA3/IL6/NTF3/IL7R/COL9A3/FGF18/PPP2R2B/FGFR2/CSF1R/ITGB8/PDGFA/MAPK3/EGFR/MAPK1/PPP2R2A/PIK3CB/ITGA2/IL7/CHRM1/CDK2/LAMC2/FGF1/FLT3LG/FGF7/G6PC3/CHRM2/FGF10/PIK3R6/PRKAA2/FGF2/IL3RA/KRAS/GNG12/LPAR4/TCL1B/KITLG/CCNE1/IL6R/EIF4B/BDNF/COL4A1/IL4/PPP2CB/CREB1/PDGFB/SPP1/COL4A5/EPOR/CDK6/FGF17/CCNE2/FGF8/CSF1/PTEN/LPAR1/FGFR4/FGFR1/ITGA9/YWHAG/ERBB4/ERBB2/AREG/PIK3R5/BRCA1/MAP2K1/FGF6/NOS3/BCL2/STK11/LAMB3/CASP9/PPP2R5D/CSF3/CSF3R/MAGI1/GNG2/MTCP1/CREB3L4/KIT/GNB4/PGF/ITGA8/CREB3L3/FOXO3/PPP2R1A/ITGA10/ITGB3/CCND2/TLR2/CDK4/EPHA2	94
KEGG	hsa00430	Taurine and hypotaurine metabolism	7/1853	16/8135	0.05101	0.2078	0.1657	FMO3/FMO5/GGT1/GAD1/FMO4/BAAT/GGT7	7
KEGG	hsa04360	Axon guidance	51/1853	182/8135	0.0554	0.2229	0.1778	PARD6B/SEMA3E/EPHB6/BMP7/EPHA4/PARD6A/MAPK3/PAK1/MAPK1/PIK3CB/SEMA3A/SEMA4D/EFNB2/PAK2/RGMA/SRGAP3/NCK1/SLIT2/KRAS/ROCK1/SEMA6C/FES/BOC/NFATC4/PPP3CB/GNAI1/SSH3/TRPC3/PLXNA4/SEMA3G/WNT4/SSH1/SRC/SEMA4G/RND1/NTN1/PLXNB1/EPHA3/SEMA3B/PPP3R2/PLXNC1/EPHB3/LIMK2/ROBO3/NTNG2/PARD6G/SLIT3/EPHA2/NEO1/ABLIM1/LIMK1	51
KEGG	hsa05162	Measles	40/1853	139/8135	0.05764	0.225	0.1794	IL6/IL12A/IFIH1/CYCS/OAS2/PIK3CB/CDK2/MAPK10/OAS1/RAB9B/MSN/JUN/CCNE1/MX1/STAT5A/IKBKE/CDK6/HSPA6/CCNE2/EIF2AK1/FCGR2B/IL12B/IL1B/EIF2AK2/CSNK2A2/OAS3/BCL2/BAK1/CLEC4M/CD46/MYD88/CASP9/CASP3/FADD/MX2/CCND2/TLR2/CDK4/MAPK9/MAPK8	40
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	9/1853	23/8135	0.05807	0.225	0.1794	ATP1A2/GLUD2/GLS/ATP1A3/AQP1/ATP1B1/SLC4A4/GLUD1/FXYD2	9
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1853	70/8135	0.0596	0.225	0.1794	ATP6V0E2/PAK1/PTPRZ1/EGFR/TCIRG1/MAPK10/TJP1/ATP6V1E2/CXCL2/ATP6V1G3/JUN/CXCL1/ATP6AP1/SRC/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1/CASP3/JAM2/MAPK9/MAPK8	22
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1853	30/8135	0.06012	0.225	0.1794	SHMT1/GLUL/GLDC/CAT/PGP/ACSS1/GLYCTK/MCEE/CS/HYI/ACAT2	11
KEGG	hsa04970	Salivary secretion	28/1853	93/8135	0.06135	0.225	0.1794	ADCY8/GUCY1A2/PLCB4/PLCB1/ATP1A2/ADRB2/BST1/LYZL1/CST1/ATP1A3/ADCY4/PRKACB/ATP1B1/TRPV6/GNAQ/PLCB2/ATP2B3/ADCY3/PRKG2/LPO/ADRA1B/ATP2B2/CST2/CD38/PRKG1/FXYD2/MUC7/KCNN4	28
KEGG	hsa04611	Platelet activation	36/1853	124/8135	0.06156	0.225	0.1794	ADCY8/GUCY1A2/PLCB4/PLCB1/MAPK3/PLA2G4F/MAPK1/PTGIR/PIK3CB/ITGA2/FERMT3/PIK3R6/VASP/PLA2G4A/ROCK1/RAP1A/ADCY4/PRKACB/RASGRP1/JMJD7-PLA2G4B/GNAI1/VAMP8/PPP1CB/GNAQ/PPP1CC/PIK3R5/PLCB2/TLN2/SRC/ADCY3/PRKG2/NOS3/RASGRP2/FCGR2A/PRKG1/ITGB3	36
KEGG	hsa00280	Valine, leucine and isoleucine degradation	16/1853	48/8135	0.06177	0.225	0.1794	ABAT/ALDH3A2/HADH/HMGCLL1/ALDH1B1/AOX1/ACADS/HADHA/ACADSB/ALDH9A1/HMGCL/ALDH6A1/MCEE/ALDH2/ACAT2/HIBADH	16
KEGG	hsa04713	Circadian entrainment	29/1853	97/8135	0.06252	0.225	0.1794	ADCY8/GUCY1A2/GRIN2A/RPS6KA5/PLCB4/PER3/PLCB1/MAPK3/GRIA3/MAPK1/KCNJ5/GRIA1/CACNA1H/GNG12/GRIN2C/PER1/PER2/ADCY4/PRKACB/CREB1/GNAI1/KCNJ6/GNAQ/PLCB2/ADCY3/PRKG2/GNG2/GNB4/PRKG1	29
KEGG	hsa05215	Prostate cancer	29/1853	97/8135	0.06252	0.225	0.1794	FGFR2/PDGFA/MAPK3/NKX3-1/EGFR/MAPK1/PIK3CB/CDK2/TCF7/TMPRSS2/KLK3/KRAS/CCNE1/SPINT1/CREB1/AR/PDGFB/CCNE2/ARAF/MMP9/PTEN/FGFR1/ERBB2/MAP2K1/BCL2/CASP9/CREB3L4/MMP3/CREB3L3	29
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	24/1853	78/8135	0.06339	0.225	0.1794	CYP3A5/ADH1A/DHDH/ADH1C/AKR1C1/CYP3A4/GSTT1/GSTA4/CYP2A13/ADH5/CYP1A2/CYP2F1/GSTM4/CYP2A7/GSTM5/GSTM3/CYP2D6/HSD11B1L/GSTA2/HSD11B1/ALDH3A1/GSTT2/ADH4/CBR3	24
KEGG	hsa05217	Basal cell carcinoma	20/1853	63/8135	0.06398	0.225	0.1794	WNT9A/WNT16/WNT11/DVL2/WNT10B/WNT2/APC/SUFU/TCF7/AXIN1/PTCH2/BMP4/WNT4/FZD1/FZD8/BAK1/GADD45G/APC2/WNT1/GADD45B	20
KEGG	hsa04072	Phospholipase D signaling pathway	42/1853	148/8135	0.06427	0.225	0.1794	ADCY8/SHC2/PLD1/DNM1/PLCB4/PLCB1/AGTR1/MRAS/PDGFA/SHC3/MAPK3/PLA2G4F/EGFR/CYTH3/MAPK1/PIK3CB/GRM1/PIK3R6/PTGFR/KRAS/PLA2G4A/LPAR4/KITLG/DGKI/SPHK2/ADCY4/PDGFB/JMJD7-PLA2G4B/DGKZ/GAB2/LPAR1/PIK3R5/PLCB2/GRM5/MAP2K1/ADCY3/GAB1/RALB/KIT/DGKG/RRAS2/CYTH1	42
KEGG	hsa05219	Bladder cancer	14/1853	41/8135	0.06466	0.225	0.1794	THBS1/RPS6KA5/MAPK3/EGFR/MAPK1/KRAS/TYMP/ARAF/MMP9/ERBB2/MAP2K1/SRC/MMP1/CDK4	14
KEGG	hsa04621	NOD-like receptor signaling pathway	51/1853	184/8135	0.06566	0.2261	0.1803	IL6/PLCB4/PLCB1/CARD9/MAPK3/P2RX7/NEK7/CARD8/MAPK1/OAS2/DEFB103A/PYCARD/GBP1/MAPK10/OAS1/TANK/CXCL2/AIM2/PYDC1/GBP2/JUN/NOD2/ANTXR2/CXCL1/IKBKE/CARD6/MEFV/PRKCD/SUGT1/CARD16/GBP5/ATG16L1/IL1B/PLCB2/RIPK3/NLRP3/RNASEL/OAS3/ANTXR1/CASP12/BCL2/GBP3/MYD88/MAP1LC3C/NLRP1/VDAC3/RBCK1/FADD/DNM1L/MAPK9/MAPK8	51
KEGG	hsa02010	ABC transporters	15/1853	45/8135	0.06912	0.2354	0.1877	ABCC9/ABCG1/DEFB1/ABCA9/ABCC6/ABCA7/ABCA8/ABCB4/ABCC1/ABCB1/ABCC8/ABCB9/ABCC10/ABCA1/ABCC2	15
KEGG	hsa00910	Nitrogen metabolism	7/1853	17/8135	0.07018	0.2354	0.1877	CPS1/GLUL/GLUD2/CA7/CA14/GLUD1/CA12	7
KEGG	hsa05130	Pathogenic Escherichia coli infection	54/1853	197/8135	0.07108	0.2354	0.1877	TLR5/IL6/CLDN4/MYO5C/MAPK3/PAK1/MYH10/CYCS/IL1R1/CYTH3/MAPK1/MYO1G/TNFSF10/NLRP4/PYCARD/MYO1B/MAPK10/TJP1/CYFIP2/PAK2/CLDN9/MYO1D/NCK1/CLDN23/LPAR4/JUN/ROCK1/OCLN/MYH11/WIPF1/LPAR1/NCKAP1L/TUBB1/IL1B/CLDN17/ABI1/SRC/NLRP3/CLDN19/CLDN7/BAK1/MYO1A/MYD88/CASP9/CLDN22/CASP3/CLDN6/FCGR2A/CLDN11/FADD/BAIAP2/MAPK9/CYTH1/MAPK8	54
KEGG	hsa04972	Pancreatic secretion	30/1853	102/8135	0.07117	0.2354	0.1877	ADCY8/PLCB4/RAB8A/PLCB1/ATP1A2/CLCA2/BST1/RAB27B/CLCA1/ATP1A3/SCT/CTRL/RAP1A/ADCY4/ATP1B1/RAB3D/PRSS3/PRSS2/GNAQ/SLC4A4/PLCB2/ATP2B3/ADCY3/ATP2B2/CPB1/CD38/FXYD2/PNLIP/PLA2G2D/CCK	30
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1853	79/8135	0.07212	0.2362	0.1883	HGF/IL6/SHC2/FGFR2/PDGFA/SHC3/MAPK3/EGFR/MAPK1/PIK3CB/FGF2/KRAS/IL6R/PDGFB/ARAF/PTEN/ERBB2/MAP2K1/SRC/BCL2/GAB1/FOXO3/NRG1/GAS6	24
KEGG	hsa04710	Circadian rhythm	11/1853	31/8135	0.07471	0.2423	0.1932	PER3/PRKAA2/CRY2/RORB/PER1/PER2/CREB1/PRKAB1/PRKAG1/PRKAB2/NPAS2	11
KEGG	hsa05032	Morphine addiction	27/1853	91/8135	0.07633	0.2452	0.1955	ADCY8/PDE3B/PDE7B/GRK5/ADORA1/KCNJ5/PDE1B/GABRR3/GNG12/ADCY4/PRKACB/GABRR1/GNAI1/KCNJ6/PDE4D/ARRB1/OPRM1/GABBR2/GABRQ/ADCY3/ARRB2/GNG2/PDE4C/GNB4/PDE7A/PDE3A/PDE2A	27
KEGG	hsa05161	Hepatitis B	45/1853	162/8135	0.07743	0.2463	0.1964	IL6/CCNA1/MAP2K6/MAPK3/IFIH1/CYCS/MAPK1/PIK3CB/EGR3/CDK2/MAPK10/ELK1/KRAS/CCNA2/JUN/TGFB3/CCNE1/CREB1/STAT5A/IKBKE/NFATC4/TGFBR2/CCNE2/ARAF/TLR3/MMP9/CASP10/TGFBR1/ATP6AP1/MAP2K1/SRC/CASP12/BCL2/MYD88/CASP9/CASP3/CREB3L4/VDAC3/CREB3L3/SMAD4/FADD/STAT4/TLR2/MAPK9/MAPK8	45
KEGG	hsa01212	Fatty acid metabolism	18/1853	57/8135	0.07963	0.2509	0.2001	ACSL5/HADH/HSD17B8/SCP2/FADS1/ELOVL4/ACADS/ELOVL7/HSD17B12/HADHA/CPT1C/ACADSB/PPT1/FADS2/ACOX3/CPT2/ACAT2/ACSL1	18
KEGG	hsa04726	Serotonergic synapse	33/1853	115/8135	0.08148	0.253	0.2017	HTR2A/PLCB4/PLCB1/CYP2J2/MAPK3/PLA2G4F/MAPK1/KCNJ5/CYP2C18/KRAS/PLA2G4A/GNG12/KCNN2/HTR2B/PRKACB/JMJD7-PLA2G4B/GNAI1/KCNJ6/ARAF/GNAQ/HTR3E/CYP2D6/MAOB/SLC18A2/PLCB2/MAP2K1/CYP2C8/HTR1A/HTR1B/GNG2/CASP3/GNB4/HTR3B	33
KEGG	hsa05417	Lipid and atherosclerosis	58/1853	215/8135	0.08181	0.253	0.2017	IL6/PLCB4/PLCB1/CYP2J2/MAP2K6/IL12A/MAPK3/CYCS/APOA4/MAPK1/TNFSF10/PIK3CB/ABCG1/PYCARD/MAPK10/APOA1/TANK/LDLR/CXCL2/PPARG/ATF6/AGER/KRAS/JUN/CXCL1/CYP2A7/RAP1A/NCF2/IKBKE/PPP3CB/TLR6/HSPA6/NOX1/MMP9/HSPA5/IL12B/IL1B/CD40/PLCB2/ERN1/SRC/NLRP3/CYP2C8/NOS3/BCL2/MMP1/MYD88/CASP9/SOD2/PPP3R2/CASP3/MMP3/NCF4/TLR2/ABCA1/CD40LG/MAPK9/MAPK8	58
KEGG	hsa00650	Butanoate metabolism	10/1853	28/8135	0.08381	0.2568	0.2048	ACSM5/ABAT/HADH/HMGCLL1/ACADS/HADHA/GAD1/HMGCL/ACAT2/ACSM1	10
KEGG	hsa05150	Staphylococcus aureus infection	28/1853	96/8135	0.08651	0.2627	0.2095	MASP1/ITGB2/C5/KRT24/CFB/IL10/DEFB103A/KRT34/DEFB1/HLA-DQA1/C2/KRT31/HLA-DQA2/SELPLG/KRT23/CFD/KRT18/FCGR2B/HLA-DOA/KRT13/C5AR1/FCAR/C1QC/KRT33B/KRT33A/FCGR2A/CFH/C1QB	28
KEGG	hsa04215	Apoptosis - multiple species	11/1853	32/8135	0.09136	0.2749	0.2192	CYCS/MAPK10/BCL2/BAK1/CASP9/BOK/CASP3/FADD/MAPK9/PMAIP1/MAPK8	11
KEGG	hsa00512	Mucin type O-glycan biosynthesis	12/1853	36/8135	0.0977	0.2888	0.2303	GALNT13/GALNT6/GALNT9/GALNT12/ST6GALNAC4/B3GNT6/GCNT3/GALNT1/GALNT10/GALNT4/GALNT2/GCNT1	12
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	12/1853	36/8135	0.0977	0.2888	0.2303	BST1/NMNAT3/SIRT5/NT5E/AOX1/ENPP3/ENPP1/SIRT7/NNT/NT5C/CD38/NMNAT2	12
KEGG	hsa04917	Prolactin signaling pathway	21/1853	70/8135	0.09864	0.289	0.2304	SHC2/IRF1/TNFRSF11A/SHC3/MAPK3/MAPK1/PIK3CB/MAPK10/SOCS7/KRAS/STAT5A/MAP2K1/CYP17A1/SRC/SOCS5/SOCS2/GALT/FOXO3/CCND2/MAPK9/MAPK8	21
KEGG	hsa04913	Ovarian steroidogenesis	16/1853	51/8135	0.0995	0.289	0.2304	ADCY8/CYP2J2/PLA2G4F/HSD17B7/LDLR/PLA2G4A/ADCY4/PRKACB/JMJD7-PLA2G4B/BMP15/CYP17A1/ADCY3/STAR/BMP6/HSD17B1/SCARB1	16
KEGG	hsa00260	Glycine, serine and threonine metabolism	13/1853	40/8135	0.1031	0.2967	0.2366	SHMT1/GLDC/GAMT/DMGDH/CHDH/GLYCTK/MAOB/SDSL/PGAM2/PIPOX/DAO/ALAS2/GNMT	13
KEGG	hsa00340	Histidine metabolism	8/1853	22/8135	0.106	0.3026	0.2413	ALDH3A2/ASPA/ALDH1B1/ALDH9A1/MAOB/ALDH2/ALDH3A1/CNDP1	8
KEGG	hsa03250	Viral life cycle - HIV-1	19/1853	63/8135	0.1076	0.3046	0.2428	SAMHD1/MLLT3/APOBEC3D/FEZ1/APOBEC3C/APOBEC3G/KAT2B/APOBEC3H/APOBEC3F/AFF4/MX1/ELL3/SERINC3/PSIP1/PDCD6IP/BST2/PIN1/CDK9/MX2	19
KEGG	hsa05165	Human papillomavirus infection	85/1853	331/8135	0.1125	0.3157	0.2518	ATP6V0E2/PARD6B/THBS1/LAMA3/COL9A3/CCNA1/WNT9A/PPP2R2B/IRF1/ITGB8/WNT16/PARD6A/WNT11/MAPK3/DVL2/WNT10B/WNT2/EGFR/MAPK1/PPP2R2A/PIK3CB/ITGA2/TCIRG1/CDK2/LAMC2/APC/RBPJL/ATP6V1E2/RBPJ/LLGL2/RBL1/MFNG/TCF7/CRB3/ATP6V1G3/KRAS/CCNA2/CCNE1/COL4A1/AXIN1/PRKACB/PPP2CB/CREB1/MX1/IKBKE/SPP1/COL4A5/ATR/CDK6/CCNE2/TLR3/WNT4/PTEN/FZD1/LFNG/FZD8/ITGA9/ATP6AP1/HDAC1/MAP2K1/EIF2AK2/HES4/BAK1/ATP6V1F/LAMB3/PPP2R5D/ATP6V1G2/MAGI1/ATP6V1C1/ATP6V0A1/CASP3/CREB3L4/APC2/ITGA8/WNT1/CREB3L3/PPP2R1A/ITGA10/ITGB3/FADD/TUBG1/MX2/CCND2/CDK4/PARD6G	85
KEGG	hsa04310	Wnt signaling pathway	45/1853	167/8135	0.1154	0.3213	0.2562	WNT9A/PLCB4/PLCB1/WNT16/WNT11/DVL2/CBY1/WNT10B/WNT2/APC/MAPK10/RSPO3/DKK4/TCF7/RSPO1/ROR2/JUN/PORCN/AXIN1/PRKACB/NFATC4/PPP3CB/SOST/SFRP1/FOSL1/WNT4/FRAT1/FZD1/FZD8/PLCB2/CSNK2A2/PPP3R2/RSPO2/APC2/CACYBP/WNT1/DAAM2/TLE3/SMAD4/SERPINF1/CTNNBIP1/CCND2/TLE4/MAPK9/MAPK8	45
KEGG	hsa04340	Hedgehog signaling pathway	17/1853	56/8135	0.1175	0.3243	0.2586	GAS1/CDON/SUFU/CUL3/PRKACB/BOC/EFCAB7/PTCH2/ARRB1/CSNK1G2/BCL2/ARRB2/SPOPL/SCUBE2/CSNK1G1/CCND2/EVC2	17
KEGG	hsa04978	Mineral absorption	18/1853	60/8135	0.1198	0.3281	0.2616	ATP1A2/SLC8A1/SLC40A1/ATP7B/HEPH/MT1F/ATP1A3/SLC30A1/ATP1B1/TRPV6/SLC5A1/ATP2B3/SLC34A1/SLC46A1/ATP2B2/FXYD2/VDR/SLC34A2	18
KEGG	hsa01523	Antifolate resistance	10/1853	30/8135	0.1243	0.3375	0.2691	IL6/SHMT1/FOLR3/FOLR1/ABCC1/IL1B/FOLR2/SLC46A1/MTHFR/ABCC2	10
KEGG	hsa05202	Transcriptional misregulation in cancer	51/1853	193/8135	0.1288	0.3434	0.2738	IL6/PBX1/CCNA1/MLLT3/CSF1R/WNT16/PDGFA/BCL2A1/ETV1/GRIA3/MITF/KLF3/SLC45A3/PPARG/TMPRSS2/CEBPA/CCNA2/FLI1/MEIS1/PER2/ATF1/JUP/SPINT1/LYL1/CSF2/HPGD/TGFBR2/ETV4/MMP9/CD40/HDAC1/SSX2/ARNT2/EWSR1/TAF15/FUT8/NR4A3/BAK1/PRCC/GADD45G/MMP3/MLF1/CDK9/GADD45B/MAX/LDB1/NFKBIZ/CCND2/JMJD1C/AFF1/SPI1	51
KEGG	hsa04660	T cell receptor signaling pathway	29/1853	104/8135	0.1298	0.3434	0.2738	MAPK3/PAK1/IL10/MAPK1/PIK3CB/PTPRC/MAPK10/PAK2/TEC/MAP3K8/NCK1/KRAS/JUN/CTLA4/PDCD1/IL4/RASGRP1/PPP3CB/CSF2/LCK/CARD11/CD247/GRAP2/MAP2K1/PPP3R2/CD40LG/CDK4/MAPK9/MAPK8	29
KEGG	hsa03020	RNA polymerase	11/1853	34/8135	0.1308	0.3434	0.2738	POLR3E/POLR2E/TWISTNB/POLR3C/POLR1E/CD3EAP/POLR2J/POLR3GL/POLR2K/ZNRD1/POLR3G	11
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	58/1853	222/8135	0.131	0.3434	0.2738	ADCY8/IL6/ITGB2/CCNA1/MAPK3/IL1R1/MAPK1/PIK3CB/KAT2B/CDK2/MSX2/MAPK10/HLA-DQA1/ELK1/SRF/ETS1/KRAS/CCNA2/JUN/TGFB3/CCNE1/ADCY4/PRKACB/CREB1/STAT5A/NFATC4/PPP3CB/ZFP36/HLA-DQA2/CSF2/ATR/SMAD2/TGFBR2/CCNE2/FOSL1/LCK/PTEN/TGFBR1/CHEK2/PTTG2/HLA-DOA/CD40/BUB1B/MAP2K1/TLN2/ADCY3/PPP3R2/CREB3L4/GPS2/VDAC3/CREB3L3/SMAD4/MAD2L1/CCND2/CDK4/MAPK9/SPI1/MAPK8	58
KEGG	hsa03060	Protein export	8/1853	23/8135	0.1316	0.3434	0.2738	SRP68/SEC61A2/IMMP2L/IMMP1L/HSPA5/SPCS3/SRP9/SEC11C	8
KEGG	hsa05211	Renal cell carcinoma	20/1853	69/8135	0.1385	0.3541	0.2823	HGF/MAPK3/PAK1/MAPK1/PIK3CB/PAK2/ETS1/KRAS/JUN/TGFB3/RAP1A/PDGFB/ARAF/ARNT2/MAP2K1/RAPGEF1/PRCC/GAB1/CRKL/FLCN	20
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/1853	27/8135	0.1408	0.3541	0.2823	B3GALT5/B3GALT2/B3GNT5/A4GALT/B3GALNT1/FUT1/ST8SIA1/FUT6/B3GALT1	9
KEGG	hsa04966	Collecting duct acid secretion	9/1853	27/8135	0.1408	0.3541	0.2823	ATP6V0E2/SLC12A7/TCIRG1/ATP6V1E2/ATP6V1G3/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1	9
KEGG	hsa04919	Thyroid hormone signaling pathway	33/1853	121/8135	0.1409	0.3541	0.2823	PLCB4/PLCB1/ATP1A2/RCAN2/MAPK3/MED12L/MED30/THRB/MAPK1/PIK3CB/NCOA2/KAT2B/DIO1/SLC16A2/KRAS/HDAC3/ATP1A3/PLCE1/PRKACB/ATP1B1/RCAN1/BMP4/PLCD3/WNT4/PLCB2/HDAC1/MAP2K1/SRC/MYH7/CASP9/MED12/FXYD2/ITGB3	33
KEGG	hsa04211	Longevity regulating pathway	25/1853	89/8135	0.1419	0.3541	0.2823	ADCY8/PPARGC1A/PIK3CB/EHMT2/KL/PRKAA2/CAT/PPARG/SESN3/KRAS/CAMKK2/ADIPOQ/ADCY4/PRKACB/CREB1/PRKAB1/CAMK4/ADCY3/STK11/PRKAG1/SOD2/PRKAB2/CREB3L4/CREB3L3/FOXO3	25
KEGG	hsa04912	GnRH signaling pathway	26/1853	93/8135	0.1421	0.3541	0.2823	ADCY8/PLD1/PLCB4/PLCB1/MAP2K6/MAPK3/PLA2G4F/EGFR/MAPK1/MAPK10/ELK1/KRAS/PLA2G4A/JUN/ADCY4/PRKACB/JMJD7-PLA2G4B/GNAQ/PRKCD/PLCB2/MAP2K1/SRC/ADCY3/MAP3K4/MAPK9/MAPK8	26
KEGG	hsa00240	Pyrimidine metabolism	17/1853	58/8135	0.1508	0.3732	0.2976	UPP1/NME7/NT5E/CTPS2/NUDT2/ENPP3/CANT1/ENPP1/TYMP/DHODH/ENTPD6/UCK1/NT5C/ASMTL/UCKL1/UPP2/RRM2	17
KEGG	hsa04721	Synaptic vesicle cycle	22/1853	78/8135	0.1555	0.3819	0.3045	ATP6V0E2/DNM1/TCIRG1/RIMS1/STX1A/ATP6V1E2/SLC1A3/ATP6V1G3/UNC13B/CLTCL1/SLC1A1/CPLX1/STX2/SLC18A2/CPLX3/ATP6V1F/ATP6V1G2/ATP6V1C1/SNAP25/ATP6V0A1/SLC1A2/UNC13A	22
KEGG	hsa04371	Apelin signaling pathway	37/1853	139/8135	0.1616	0.3934	0.3137	ADCY8/PDE3B/PLCB4/PLCB1/PPARGC1A/AGTR1/MRAS/SLC8A1/MAPK3/MAPK1/PIK3R6/PRKAA2/PRKCE/KRAS/GNG12/SPHK2/ADCY4/PRKACB/SPP1/GNAI1/SMAD2/GNAQ/TGFBR1/PRKAB1/PIK3R5/PLCB2/CAMK4/MAP2K1/ADCY3/NOS3/PRKAG1/MAP1LC3C/GNG2/PRKAB2/GNB4/RRAS2/SMAD4	37
KEGG	hsa00620	Pyruvate metabolism	14/1853	47/8135	0.1642	0.3934	0.3137	ADH1A/ALDH3A2/ADH1C/ALDH1B1/PC/ADH5/ACSS1/ALDH9A1/ACACB/ME2/ACYP1/ALDH2/ADH4/ACAT2	14
KEGG	hsa04973	Carbohydrate digestion and absorption	14/1853	47/8135	0.1642	0.3934	0.3137	PLCB4/PLCB1/ATP1A2/MGAM/PIK3CB/G6PC3/SLC2A5/ATP1A3/ATP1B1/SLC37A4/SLC5A1/PLCB2/TAS1R2/FXYD2	14
KEGG	hsa04510	Focal adhesion	52/1853	201/8135	0.1649	0.3934	0.3137	HGF/THBS1/LAMA3/SHC2/PPP1R12B/COL9A3/ITGB8/PDGFA/SHC3/MAPK3/PAK1/EGFR/MAPK1/PIK3CB/ITGA2/LAMC2/MAPK10/PAK2/ELK1/VASP/MYLPF/MYL7/JUN/ROCK1/ACTN1/RAP1A/COL4A1/PDGFB/SPP1/COL4A5/PPP1CB/FLNC/PTEN/PPP1CC/ITGA9/ERBB2/MAP2K1/RASGRF1/RAPGEF1/TLN2/SRC/BCL2/PARVG/LAMB3/CRKL/PGF/ITGA8/ITGA10/ITGB3/CCND2/MAPK9/MAPK8	52
KEGG	hsa04370	VEGF signaling pathway	17/1853	59/8135	0.1693	0.401	0.3197	SHC2/MAPK3/PLA2G4F/MAPK1/PIK3CB/KRAS/PLA2G4A/SPHK2/JMJD7-PLA2G4B/PPP3CB/SH2D2A/MAPKAPK3/MAP2K1/SRC/NOS3/CASP9/PPP3R2	17
KEGG	hsa00640	Propanoate metabolism	10/1853	32/8135	0.1736	0.4083	0.3256	ABAT/ACADS/SUCLG2/HADHA/ACSS1/ACACB/ALDH6A1/MCEE/ACOX3/ACSS3	10
KEGG	hsa04728	Dopaminergic synapse	35/1853	132/8135	0.1761	0.4113	0.3279	GRIN2A/PLCB4/PPP2R2B/PLCB1/GRIA3/PPP2R2A/KCNJ5/GRIA1/MAPK10/KIF5C/GNG12/PRKACB/PPP2CB/CREB1/PPP3CB/GNAI1/KCNJ6/PPP1CB/ARRB1/DRD2/GNAQ/PPP1CC/MAOB/DRD4/SLC18A2/PLCB2/ARRB2/PPP2R5D/GNG2/CREB3L4/GNB4/CREB3L3/PPP2R1A/MAPK9/MAPK8	35
KEGG	hsa05145	Toxoplasmosis	30/1853	112/8135	0.1817	0.4181	0.3334	LAMA3/MAP2K6/IL12A/MAPK3/CYCS/IL10/MAPK1/LAMC2/MAPK10/HLA-DQA1/PIK3R6/LDLR/TGFB3/GNAI1/HLA-DQA2/HSPA6/HLA-DOA/IL12B/CD40/PIK3R5/PPIF/BCL2/LAMB3/MYD88/CASP9/CASP3/TLR2/CD40LG/MAPK9/MAPK8	30
KEGG	hsa04659	Th17 cell differentiation	29/1853	108/8135	0.1828	0.4181	0.3334	IL6/IL12RB1/MAPK3/IL1R1/MAPK1/IL27RA/MAPK10/HLA-DQA1/IL17F/JUN/IL6R/IL4/STAT5A/PPP3CB/IL21/HLA-DQA2/SMAD2/TGFBR2/FOXP3/LCK/IL17A/TGFBR1/CD247/HLA-DOA/IL1B/PPP3R2/SMAD4/MAPK9/MAPK8	29
KEGG	hsa04931	Insulin resistance	29/1853	108/8135	0.1828	0.4181	0.3334	IL6/PPARGC1A/PYGB/RPS6KA6/PIK3CB/MAPK10/G6PC3/MLXIPL/PRKAA2/PRKCE/CREB1/OGT/PPP1CB/PTEN/PPP1CC/ACACB/PRKCD/GFPT1/PRKAB1/NOS3/RPS6KA3/PRKAG1/PRKAB2/PPP1R3C/CREB3L4/CREB3L3/GFPT2/MAPK9/MAPK8	29
KEGG	hsa04910	Insulin signaling pathway	36/1853	137/8135	0.1877	0.4261	0.3398	PDE3B/SHC2/PPARGC1A/PYGB/SHC3/MAPK3/MAPK1/PIK3CB/MAPK10/G6PC3/ELK1/PRKAA2/EXOC7/PHKA1/KRAS/PRKACB/PRKAR2B/TRIP10/PPP1CB/ARAF/PPP1CC/ACACB/PRKAB1/MAP2K1/RAPGEF1/MKNK2/PRKAG1/CRKL/PRKAB2/PPP1R3C/FLOT2/SORBS1/SOCS2/SH2B2/MAPK9/MAPK8	36
KEGG	hsa05220	Chronic myeloid leukemia	21/1853	76/8135	0.1888	0.4261	0.3398	SHC2/SHC3/MAPK3/MAPK1/PIK3CB/KRAS/TGFB3/STAT5A/CDK6/TGFBR2/ARAF/GAB2/TGFBR1/HDAC1/MAP2K1/BAK1/GADD45G/CRKL/GADD45B/SMAD4/CDK4	21
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	54/1853	212/8135	0.1926	0.4318	0.3443	ADCY8/FGF16/FGF18/MAPK3/ADRB2/CYP3A4/GSTT1/RPS6KA6/EGFR/KLF4/MAPK1/PIK3CB/GSTA4/PAQR7/FGF7/FGF10/EPHX2/PGR/FGF2/KRAS/JUN/CYP1A2/GSTM4/ADCY4/PRKACB/CREB1/AR/STAT5A/IKBKE/GNAI1/FGF17/ARRB1/FGF8/GSTM5/KLF5/GSTM3/PAQR8/GSTA2/MAP2K1/SRC/ADCY3/FGF6/BCL2/GSTT2/RPS6KA3/ARRB2/CREB3L4/PTGES3/WNT1/CREB3L3/VDR/CHRNB2/CDC6/CHRNA7	54
KEGG	hsa00591	Linoleic acid metabolism	9/1853	29/8135	0.1969	0.4356	0.3473	PLB1/CYP2J2/CYP3A4/PLA2G4F/PLA2G4A/CYP1A2/JMJD7-PLA2G4B/CYP2C8/PLA2G2D	9
KEGG	hsa04392	Hippo signaling pathway - multiple species	9/1853	29/8135	0.1969	0.4356	0.3473	RASSF2/PAK1/TEAD1/DCHS1/FAT4/WWTR1/YAP1/LATS2/RASSF4	9
KEGG	hsa04062	Chemokine signaling pathway	49/1853	192/8135	0.2019	0.4437	0.3538	ADCY8/SHC2/PF4V1/ELMO1/GRK5/PLCB4/PLCB1/CXCL6/SHC3/MAPK3/PAK1/MAPK1/HCK/PIK3CB/CCL21/PIK3R6/CXCL2/CX3CR1/CCR1/KRAS/GNG12/ROCK1/CXCL1/RAP1A/ADCY4/PRKACB/GNAI1/ARRB1/GNAQ/PRKCD/PREX1/CCL18/PIK3R5/PLCB2/CCL15/MAP2K1/SRC/ADCY3/XCR1/ARRB2/CRKL/GNG2/RASGRP2/CXCL5/GNB4/CXCL10/CCL4/FOXO3/GRK1	49
KEGG	hsa05216	Thyroid cancer	11/1853	37/8135	0.2043	0.4458	0.3554	MAPK3/MAPK1/TCF7/PPARG/KRAS/NCOA4/TPM3/MAP2K1/BAK1/GADD45G/GADD45B	11
KEGG	hsa04920	Adipocytokine signaling pathway	19/1853	69/8135	0.2085	0.4458	0.3554	ACSL5/PPARGC1A/TNFRSF1B/MAPK10/G6PC3/PRKAA2/CAMKK2/ADIPOQ/CPT1C/ACACB/PRKAB1/STK11/PRKAG1/PRKAB2/AGRP/LEPR/MAPK9/ACSL1/MAPK8	19
KEGG	hsa05031	Amphetamine addiction	19/1853	69/8135	0.2085	0.4458	0.3554	GRIN2A/GRIA3/GRIN3A/GRIA1/STX1A/GRIN2C/JUN/PRKACB/CREB1/PPP3CB/PPP1CB/PPP1CC/MAOB/SLC18A2/CAMK4/HDAC1/PPP3R2/CREB3L4/CREB3L3	19
KEGG	hsa00561	Glycerolipid metabolism	17/1853	61/8135	0.2094	0.4458	0.3554	DGAT2/MBOAT1/ALDH3A2/ALDH1B1/LPIN1/LCLAT1/LIPC/DGKI/MOGAT2/DGKZ/ALDH9A1/GLYCTK/AKR1B10/LIPG/ALDH2/PNLIP/DGKG	17
KEGG	hsa05134	Legionellosis	16/1853	57/8135	0.2095	0.4458	0.3554	TLR5/IL6/ITGB2/IL12A/CYCS/PYCARD/CXCL2/CXCL1/HSPA6/IL12B/IL1B/MYD88/CASP9/CASP3/BCL2L13/TLR2	16
KEGG	hsa04742	Taste transduction	23/1853	86/8135	0.2229	0.4686	0.3736	ADCY8/SCN2A/KCNK5/PLCB4/PLCB1/PKD1L3/TAS2R13/PDE1B/GRM1/ADCY4/PRKACB/CALHM1/TAS2R10/SCN3A/GABBR2/HTR3E/P2RX2/PLCB2/TRPM5/TAS1R2/HTR1A/HTR1B/HTR3B	23
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1853	26/8135	0.2242	0.4686	0.3736	PIGU/GPLD1/PIGX/PIGS/PIGF/PIGC/PIGV/PIGN	8
KEGG	hsa04146	Peroxisome	22/1853	82/8135	0.2245	0.4686	0.3736	ACSL5/MPV17L/HMGCLL1/FAR2/SCP2/CAT/EPHX2/PECR/CRAT/DDO/HMGCL/PEX7/ACOX3/XDH/PIPOX/SOD2/DAO/PEX5/BAAT/NUDT7/MPV17/ACSL1	22
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1853	11/8135	0.2275	0.4719	0.3763	HPD/COQ7/COQ5/VKORC1L1	4
KEGG	hsa00480	Glutathione metabolism	16/1853	58/8135	0.2319	0.4747	0.3785	GSTT1/GSTA4/LAP3/GGT1/PGD/GCLM/GSTM4/ANPEP/CHAC1/GSTM5/GSTM3/GSTA2/SMS/GSTT2/RRM2/GGT7	16
KEGG	hsa05110	Vibrio cholerae infection	14/1853	50/8135	0.2331	0.4747	0.3785	ATP6V0E2/TCIRG1/SEC61A2/TJP1/ATP6V1E2/TJP2/ATP6V1G3/PRKACB/ATP6AP1/ADCY3/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1	14
KEGG	hsa05144	Malaria	14/1853	50/8135	0.2331	0.4747	0.3785	HGF/THBS1/IL6/ITGB2/IL12A/IL10/TGFB3/IL1B/CD40/MYD88/CSF3/KLRB1/TLR2/CD40LG	14
KEGG	hsa04630	JAK-STAT signaling pathway	41/1853	162/8135	0.2451	0.4962	0.3957	IL6/IL7R/PDGFA/IL12RB1/IL12A/EGFR/IL10/CSF2RB/PIK3CB/IL27RA/IL7/CNTFR/AOX1/PIAS3/SOCS7/MPL/IL3RA/CTF1/IL11RA/IL6R/IL4/IL17D/PDGFB/STAT5A/IL21/CSF2/EPOR/IL19/IL12B/CRLF2/TSLP/BCL2/SOCS5/CSF3/CSF3R/IFNW1/SOCS2/LEPR/STAT4/IL20RA/CCND2	41
KEGG	hsa05214	Glioma	20/1853	75/8135	0.2477	0.4983	0.3974	SHC2/PDGFA/SHC3/MAPK3/EGFR/MAPK1/PIK3CB/CAMK1/CAMK1G/KRAS/PDGFB/CDK6/ARAF/PTEN/CAMK4/MAP2K1/BAK1/GADD45G/GADD45B/CDK4	20
KEGG	hsa04520	Adherens junction	19/1853	71/8135	0.2497	0.4983	0.3974	MAPK3/EGFR/MAPK1/SNAI1/SSX2IP/PTPRB/TJP1/TCF7/ACTN1/TGFBR2/TGFBR1/FGFR1/ERBB2/CTNNA3/SRC/CSNK2A2/SORBS1/SMAD4/BAIAP2	19
KEGG	hsa05221	Acute myeloid leukemia	18/1853	67/8135	0.2516	0.4983	0.3974	CCNA1/CSF1R/MAPK3/BCL2A1/MAPK1/PIK3CB/TCF7/CEBPA/KRAS/CCNA2/PER2/JUP/STAT5A/CSF2/ARAF/MAP2K1/KIT/SPI1	18
KEGG	hsa00310	Lysine degradation	17/1853	63/8135	0.2534	0.4983	0.3974	ALDH3A2/HADH/PRDM16/EHMT2/ALDH1B1/PLOD2/SETDB1/HADHA/SMYD3/ALDH9A1/SUV39H1/TMLHE/ALDH2/PIPOX/SMYD2/ACAT2/SUV39H2	17
KEGG	hsa05414	Dilated cardiomyopathy	25/1853	96/8135	0.2556	0.4983	0.3974	ADCY8/ITGB8/SLC8A1/ITGA2/TTN/SGCD/CACNB2/CACNG4/TGFB3/ADCY4/PRKACB/DMD/ITGA9/EMD/CACNA2D3/TPM3/CACNA2D1/ADCY3/TNNT2/ACTC1/CACNG5/MYH7/ITGA8/ITGA10/ITGB3	25
KEGG	hsa05205	Proteoglycans in cancer	51/1853	205/8135	0.2578	0.4983	0.3974	HGF/HPSE/THBS1/PPP1R12B/WNT9A/ANK1/MRAS/WNT16/WNT11/MAPK3/PAK1/WNT10B/WNT2/EGFR/MAPK1/PIK3CB/ITGA2/ANK3/ELK1/FGF2/MSN/KRAS/TFAP4/ROCK1/PLCE1/EIF4B/PRKACB/TWIST2/SMAD2/PPP1CB/FLNC/ARAF/WNT4/MMP9/FZD1/PPP1CC/FZD8/PDCD4/FGFR1/ERBB4/ERBB2/IL12B/MAP2K1/SRC/GAB1/HOXD10/CASP3/WNT1/RRAS2/ITGB3/TLR2	51
KEGG	hsa00330	Arginine and proline metabolism	14/1853	51/8135	0.2583	0.4983	0.3974	ALDH3A2/ALDH1B1/LAP3/GAMT/ALDH9A1/AGMAT/PYCR1/MAOB/P4HA3/SMS/NOS3/ALDH2/CNDP1/DAO	14
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	8/1853	27/8135	0.2593	0.4983	0.3974	SCP2/FADS1/ELOVL4/ELOVL7/HSD17B12/FADS2/ACOX3/BAAT	8
KEGG	hsa00514	Other types of O-glycan biosynthesis	13/1853	47/8135	0.2596	0.4983	0.3974	GALNT13/GALNT6/GALNT9/GALNT12/MFNG/OGT/POFUT2/LFNG/GALNT1/GALNT10/GALNT4/GALNT2/POFUT1	13
KEGG	hsa05152	Tuberculosis	45/1853	180/8135	0.2617	0.4994	0.3982	IL6/ITGB2/CARD9/IL12A/MAPK3/CYCS/IL10/MAPK1/TCIRG1/MAPK10/HLA-DQA1/NOD2/TGFB3/SPHK2/TLR1/CTSS/CREB1/PPP3CB/HLA-DQA2/TLR6/CORO1A/CASP10/ATP6AP1/FCGR2B/HLA-DOA/IL12B/IL1B/RAB5C/SRC/RFXAP/BCL2/CLEC4M/MYD88/CASP9/PPP3R2/ATP6V0A1/CASP3/PLK3/FCGR2A/LSP1/VDR/FADD/TLR2/MAPK9/MAPK8	45
KEGG	hsa00983	Drug metabolism - other enzymes	21/1853	80/8135	0.266	0.5049	0.4026	UPP1/NME7/CYP3A4/GSTT1/CES2/GSTA4/TYMP/GSTM4/CYP2A7/GSTM5/GSTM3/GSTA2/GMPS/UCK1/XDH/GSTT2/UCKL1/HPRT1/UPP2/RRM2/IMPDH2	21
KEGG	hsa05223	Non-small cell lung cancer	19/1853	72/8135	0.2714	0.5091	0.4059	HGF/RASSF5/MAPK3/EGFR/MAPK1/PIK3CB/KIF5C/KRAS/STAT5A/CDK6/ARAF/ERBB2/MAP2K1/BAK1/GADD45G/CASP9/FOXO3/GADD45B/CDK4	19
KEGG	hsa00830	Retinol metabolism	18/1853	68/8135	0.274	0.5091	0.4059	CYP3A5/ADH1A/ADH1C/CYP3A4/CYP3A7/CYP26B1/RDH5/ALDH1A1/CYP2C18/ALDH1A3/AOX1/ADH5/DHRS3/CYP1A2/CYP2A7/RDH13/CYP2C8/ADH4	18
KEGG	hsa03015	mRNA surveillance pathway	25/1853	97/8135	0.2743	0.5091	0.4059	PPP2R2B/GLE1/PPP2R2A/PABPC4L/WDR33/UPF3A/PABPC4/PPP2CB/SRRM1/MAGOHB/PPP1CB/CSTF1/PPP1CC/PELO/RNGTT/SMG1/PCF11/FIP1L1/ETF1/NCBP2/PPP2R5D/GSPT1/DDX19B/MSI1/PPP2R1A	25
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	25/1853	97/8135	0.2743	0.5091	0.4059	PLD1/MAPK3/PAK1/PLA2G4F/BIN1/MAPK1/HCK/PIK3CB/PTPRC/PRKCE/MARCKSL1/VASP/PLA2G4A/SPHK2/AMPH/JMJD7-PLA2G4B/GAB2/PRKCD/FCGR2B/MAP2K1/CRKL/FCGR2A/LIMK2/ASAP1/LIMK1	25
KEGG	hsa04976	Bile secretion	23/1853	89/8135	0.2806	0.5169	0.4122	ADCY8/ATP1A2/CYP3A4/SLC4A5/CYP7A1/LDLR/ATP1A3/KCNN2/SCT/AQP1/ADCY4/PRKACB/ABCB4/ATP1B1/ABCB1/SLC4A4/SLC5A1/ADCY3/NR0B2/FXYD2/BAAT/SCARB1/ABCC2	23
KEGG	hsa04114	Oocyte meiosis	33/1853	131/8135	0.2839	0.5169	0.4122	ADCY8/MAPK3/RPS6KA6/MAPK1/CDK2/CPEB1/PGR/CCNE1/ADCY4/PRKACB/PPP2CB/AR/AURKA/PLK1/PPP3CB/FBXO5/SMC1B/CCNE2/PPP1CB/PPP1CC/CCNB1/PTTG2/YWHAG/CPEB2/CDC25C/MAP2K1/ADCY3/RPS6KA3/PPP2R5D/PPP3R2/PPP2R1A/MAD2L1/BUB1	33
KEGG	hsa00600	Sphingolipid metabolism	14/1853	52/8135	0.2845	0.5169	0.4122	SPTLC3/B4GALT6/CERK/B4GALNT1/SGPL1/SPHK2/SMPD1/ACER1/HEXA/ARSA/UGCG/DEGS1/SGMS2/NEU1	14
KEGG	hsa04723	Retrograde endocannabinoid signaling	37/1853	148/8135	0.2866	0.5169	0.4122	ADCY8/PLCB4/PLCB1/MAPK3/GRIA3/MAPK1/KCNJ5/GRIA1/RIMS1/NDUFA10/MAPK10/GRM1/GABRR3/NDUFS6/GNG12/ADCY4/PRKACB/GABRR1/FAAH/GNAI1/KCNJ6/ND3/GNAQ/PLCB2/GRM5/NAPEPLD/NDUFS3/GABRQ/ADCY3/GNG2/GNB4/NDUFS2/ND2/NDUFA13/NDUFB11/MAPK9/MAPK8	37
KEGG	hsa05140	Leishmaniasis	20/1853	77/8135	0.2903	0.5169	0.4122	ITGB2/IL12A/MAPK3/IL10/MAPK1/HLA-DQA1/ELK1/MARCKSL1/JUN/TGFB3/NCF2/IL4/HLA-DQA2/HLA-DOA/IL12B/IL1B/MYD88/FCGR2A/NCF4/TLR2	20
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1853	77/8135	0.2903	0.5169	0.4122	ITGB8/SLC8A1/ITGA2/TCF7/SGCD/CACNB2/CACNG4/PKP2/JUP/DSP/DMD/ITGA9/EMD/CACNA2D3/CTNNA3/CACNA2D1/CACNG5/ITGA8/ITGA10/ITGB3	20
KEGG	hsa00350	Tyrosine metabolism	10/1853	36/8135	0.2934	0.5169	0.4122	ADH1A/HGD/HPD/ADH1C/AOX1/ADH5/MAOB/FAH/ALDH3A1/ADH4	10
KEGG	hsa04722	Neurotrophin signaling pathway	30/1853	119/8135	0.2943	0.5169	0.4122	NTF3/SHC2/RPS6KA5/SHC3/MAPK3/MAP2K5/RPS6KA6/MAPK1/PIK3CB/MAPK10/KRAS/JUN/RAP1A/BDNF/PRKCD/ARHGDIB/CAMK4/MAP2K1/RAPGEF1/NTRK3/BCL2/RPS6KA3/GAB1/CRKL/MATK/SH2B2/FOXO3/PSEN2/MAPK9/MAPK8	30
KEGG	hsa04935	Growth hormone synthesis, secretion and action	30/1853	119/8135	0.2943	0.5169	0.4122	ADCY8/SHC2/PLCB4/PLCB1/MAP2K6/SHC3/MAPK3/MAPK1/SSTR1/PIK3CB/MAPK10/KRAS/ADCY4/PRKACB/CREB1/GHRHR/STAT5A/GNAI1/GNAQ/PLCB2/MAP2K1/ADCY3/GHRH/CRKL/CREB3L4/SOCS2/CREB3L3/SST/MAPK9/MAPK8	30
KEGG	hsa00100	Steroid biosynthesis	6/1853	20/8135	0.2949	0.5169	0.4122	SOAT2/HSD17B7/TM7SF2/SOAT1/DHCR7/FDFT1	6
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1853	24/8135	0.2961	0.5169	0.4122	HS3ST1/HS3ST2/HS3ST3B1/EXTL1/HS6ST3/HS3ST5/HS3ST3A1	7
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	18/1853	69/8135	0.2972	0.5169	0.4122	CYP3A5/CYP3A4/CYP3A7/GSTT1/GSTA4/CYP2C18/CYP2A13/CYP1A2/GSTM4/CYP2A7/CYP3A43/GSTM5/GSTM3/HSD11B1L/GSTA2/HSD11B1/CYP2C8/GSTT2	18
KEGG	hsa05164	Influenza A	42/1853	171/8135	0.3149	0.5427	0.4327	IL6/RAE1/IL12A/MAPK3/IFIH1/RSAD2/IL33/CYCS/CALCOCO2/MAPK1/TNFSF10/OAS2/PIK3CB/PYCARD/HLA-DQA1/OAS1/TMPRSS2/MX1/IKBKE/HLA-DQA2/CDK6/TLR3/PRSS3/PRSS2/HLA-DOA/IL12B/IL1B/MAP2K1/NLRP3/EIF2AK2/RNASEL/OAS3/TRIM25/DNAJB1/BAK1/MYD88/CASP9/CASP3/CXCL10/FADD/MX2/CDK4	42
KEGG	hsa00565	Ether lipid metabolism	13/1853	49/8135	0.3152	0.5427	0.4327	GDPD3/PLB1/PLD1/PLA2G7/PLA2G4F/PLA2G4A/JMJD7-PLA2G4B/PAFAH1B2/GDPD1/CHPT1/PLA2G2D/PAFAH2/PLD4	13
KEGG	hsa04216	Ferroptosis	11/1853	41/8135	0.3227	0.5527	0.4407	ACSL5/SLC40A1/STEAP3/GCLM/SLC39A8/CP/SLC39A14/NCOA4/MAP1LC3C/VDAC3/ACSL1	11
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	10/1853	37/8135	0.3265	0.5541	0.4418	ATP1A2/MAPK3/MAPK1/PIK3CB/KRAS/ATP1A3/ATP1B1/SLC9A3R2/SFN/FXYD2	10
KEGG	hsa04620	Toll-like receptor signaling pathway	26/1853	104/8135	0.3289	0.5541	0.4418	TLR5/IL6/MAP2K6/IL12A/MAPK3/MAPK1/PIK3CB/MAPK10/MAP3K8/JUN/TLR1/IKBKE/SPP1/TLR6/TLR3/IL12B/IL1B/CD40/MAP2K1/MYD88/CXCL10/CCL4/FADD/TLR2/MAPK9/MAPK8	26
KEGG	hsa03410	Base excision repair	9/1853	33/8135	0.3301	0.5541	0.4418	UNG/OGG1/POLD2/POLL/APEX1/PARP1/NEIL3/NEIL2/POLE	9
KEGG	hsa04130	SNARE interactions in vesicular transport	9/1853	33/8135	0.3301	0.5541	0.4418	VAMP1/VAMP4/STX6/STX11/VTI1A/STX1A/YKT6/VAMP8/STX2	9
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	25/1853	100/8135	0.3334	0.5568	0.444	IL6/PF4V1/CSF1R/CXCL6/TNFRSF1B/IL18R1/IL10/TNFSF10/CCL21/CXCL2/CX3CR1/CCR1/CXCL1/IL6R/CSF1/IL19/CCL18/CCL15/XCR1/CXCL5/CXCL10/CCL4/TNFRSF10C/IL20RA/TNFRSF14	25
KEGG	hsa00592	alpha-Linolenic acid metabolism	7/1853	25/8135	0.337	0.5599	0.4465	PLB1/PLA2G4F/PLA2G4A/JMJD7-PLA2G4B/FADS2/ACOX3/PLA2G2D	7
KEGG	hsa00120	Primary bile acid biosynthesis	5/1853	17/8135	0.3416	0.5648	0.4503	CYP39A1/CYP27A1/SCP2/CYP7A1/BAAT	5
KEGG	hsa04150	mTOR signaling pathway	38/1853	156/8135	0.3471	0.5711	0.4553	CAB39L/WNT9A/WNT16/WNT11/PRR5/MAPK3/DVL2/WNT10B/FNIP1/RPS6KA6/WNT2/MAPK1/PIK3CB/LPIN1/ATP6V1E2/PRKAA2/ATP6V1G3/KRAS/TBC1D7/EIF4B/GRB10/WNT4/PTEN/FZD1/FZD8/SKP2/STRADB/RNF152/RRAGB/MAP2K1/STK11/RPS6KA3/ATP6V1F/ATP6V1G2/ATP6V1C1/CLIP1/WNT1/FLCN	38
KEGG	hsa04930	Type II diabetes mellitus	12/1853	46/8135	0.3492	0.5718	0.4559	MAPK3/MAPK1/PIK3CB/MAPK10/PRKCE/ADIPOQ/PRKCD/PDX1/ABCC8/SOCS2/MAPK9/MAPK8	12
KEGG	hsa04623	Cytosolic DNA-sensing pathway	16/1853	63/8135	0.3556	0.5793	0.4619	IL6/IL33/PYCARD/POLR3E/POLR2E/AIM2/POLR3C/IKBKE/IL1B/POLR3GL/RIPK3/POLR2K/CXCL10/ZBP1/CCL4/POLR3G	16
KEGG	hsa04670	Leukocyte transendothelial migration	28/1853	114/8135	0.3587	0.5793	0.4619	CLDN4/ITGB2/RASSF5/PIK3CB/CLDN9/MSN/CDH5/CLDN23/VASP/MYLPF/MYL7/ROCK1/ACTN1/RAP1A/CD99L2/NCF2/GNAI1/OCLN/MMP9/CTNNA3/CLDN17/CLDN19/CLDN7/CLDN22/CLDN6/CLDN11/JAM2/NCF4	28
KEGG	hsa04070	Phosphatidylinositol signaling system	24/1853	97/8135	0.359	0.5793	0.4619	PLCB4/PLCB1/PIK3CB/CDS1/SYNJ2/MTMR4/INPP5E/IMPA2/MTMR14/CDIPT/INPP1/DGKI/PLCE1/DGKZ/PLCD3/PI4KB/PTEN/PI4KA/PLCB2/IPMK/OCRL/MTMR8/ITPKB/DGKG	24
KEGG	hsa04330	Notch signaling pathway	15/1853	59/8135	0.3613	0.5801	0.4626	DVL2/KAT2B/RBPJL/DTX3L/RBPJ/MFNG/DTX4/DTX2/DTX1/DTX3/LFNG/HDAC1/TLE3/PSEN2/TLE4	15
KEGG	hsa04210	Apoptosis	33/1853	136/8135	0.3707	0.5925	0.4724	MAPK3/BCL2A1/CYCS/MAPK1/TNFSF10/CSF2RB/PIK3CB/MAPK10/SPTA1/CTSO/IL3RA/KRAS/JUN/CTSS/PARP1/CTSH/CASP10/ENDOG/ERN1/MAP2K1/CASP12/BCL2/BAK1/GADD45G/CASP9/CASP3/GADD45B/PTPN13/FADD/MAPK9/PMAIP1/DFFB/MAPK8	33
KEGG	hsa01522	Endocrine resistance	24/1853	98/8135	0.3802	0.6048	0.4822	ADCY8/SHC2/SHC3/MAPK3/EGFR/MAPK1/PIK3CB/MAPK10/BIK/KRAS/JUN/ADCY4/PRKACB/ARAF/MMP9/CYP2D6/ERBB2/MAP2K1/SRC/ADCY3/BCL2/CDK4/MAPK9/MAPK8	24
KEGG	hsa04140	Autophagy - animal	34/1853	141/8135	0.3835	0.6069	0.4839	RAB8A/MRAS/MAPK3/MAPK1/PIK3CB/MAPK10/MTMR4/TANK/PRKAA2/MTMR14/KRAS/RAB7B/CAMKK2/PRKACB/PPP2CB/VAMP8/PRAP1/PTEN/PRKCD/ATG16L1/ERN1/RRAGB/MAP2K1/RAB39B/BCL2/STK11/IGBP1/MAP1LC3C/ATG4C/RAB33B/RRAS2/UVRAG/MAPK9/MAPK8	34
KEGG	hsa00220	Arginine biosynthesis	6/1853	22/8135	0.3852	0.6069	0.4839	CPS1/GLUL/GLUD2/GLS/NOS3/GLUD1	6
KEGG	hsa04152	AMPK signaling pathway	29/1853	120/8135	0.3922	0.615	0.4903	CAB39L/CCNA1/PPP2R2B/RAB8A/PPARGC1A/PPP2R2A/PIK3CB/G6PC3/PRKAA2/PPARG/CCNA2/CAMKK2/ADIPOQ/PPP2CB/CPT1C/CREB1/ACACB/STRADB/PRKAB1/EEF2K/STK11/PRKAG1/PPP2R5D/PRKAB2/CREB3L4/CREB3L3/FOXO3/PPP2R1A/LEPR	29
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1853	14/8135	0.3996	0.6237	0.4973	CHST6/CHST4/FUT8/CHST2	4
KEGG	hsa00920	Sulfur metabolism	3/1853	10/8135	0.4069	0.6322	0.5041	SELENBP1/BPNT1/TST	3
KEGG	hsa00590	Arachidonic acid metabolism	15/1853	61/8135	0.4161	0.6434	0.513	PLB1/CYP2J2/PLA2G4F/EPHX2/PTGIS/PLA2G4A/LTC4S/GGT1/JMJD7-PLA2G4B/CYP2U1/CYP2C8/PTGES3/PLA2G2D/CBR3/LTA4H	15
KEGG	hsa04962	Vasopressin-regulated water reabsorption	11/1853	44/8135	0.4194	0.6455	0.5147	AQP3/DYNC2LI1/PRKACB/CREB1/DYNLL2/ARHGDIB/RAB5C/ADCY3/CREB3L4/CREB3L3/DCTN5	11
KEGG	hsa05033	Nicotine addiction	10/1853	40/8135	0.4285	0.6565	0.5235	GRIN2A/GRIA3/GRIN3A/GRIA1/GABRR3/GRIN2C/GABRR1/GABRQ/CHRNB2/CHRNA7	10
KEGG	hsa05222	Small cell lung cancer	22/1853	92/8135	0.4373	0.667	0.5318	LAMA3/CYCS/PIK3CB/ITGA2/CDK2/LAMC2/CCNE1/COL4A1/COL4A5/CDK6/CCNE2/PTEN/SKP2/BCL2/BAK1/LAMB3/GADD45G/CASP9/CASP3/GADD45B/MAX/CDK4	22
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	12/1853	49/8135	0.4419	0.6706	0.5347	CMAS/AMDHD2/CHIA/GALK2/GNE/CYB5RL/HEXA/PMM1/GFPT1/GNPDA1/GALT/GFPT2	12
KEGG	hsa04213	Longevity regulating pathway - multiple species	15/1853	62/8135	0.4437	0.6706	0.5347	ADCY8/PIK3CB/PRKAA2/CAT/KRAS/ADCY4/PRKACB/HSPA6/PRKAB1/HDAC1/ADCY3/PRKAG1/SOD2/PRKAB2/FOXO3	15
KEGG	hsa04141	Protein processing in endoplasmic reticulum	40/1853	171/8135	0.4534	0.6821	0.5439	MAN1C1/GANAB/TUSC3/SEC61A2/MAPK10/MAN1A1/UBE2G1/NGLY1/ATF6/SSR3/UBXN2A/HSPA4L/YOD1/AMFR/HSPA6/HSPA5/EIF2AK1/SVIP/DNAJC5B/SEC23B/ERN1/ATXN3/EIF2AK2/PDIA6/CASP12/BCL2/DNAJB1/BAK1/SSR1/UBE2D4/UBQLN4/UBE2D1/SSR4/LMAN1L/UBE2G2/DERL3/MBTPS2/MAPK9/UBE2J2/MAPK8	40
KEGG	hsa00730	Thiamine metabolism	4/1853	15/8135	0.4568	0.6841	0.5455	AK7/AK5/ALPI/TPK1	4
KEGG	hsa01200	Carbon metabolism	27/1853	115/8135	0.4649	0.6932	0.5528	CPS1/SHMT1/SDHA/PC/GLDC/GLUD2/CAT/ACADS/ADH5/SUCLG2/PGD/PGP/ACSS1/PGLS/GLYCTK/ME2/SDSL/ALDH6A1/MCEE/PGAM2/ACOX3/CS/ADPGK/ENO3/GLUD1/ACAT2/SDHD	27
KEGG	hsa04727	GABAergic synapse	21/1853	89/8135	0.468	0.6947	0.5539	ADCY8/ABAT/GLUL/GABRR3/GLS/GNG12/ADCY4/PRKACB/GABRR1/GNAI1/KCNJ6/SLC12A5/GAD1/GABBR2/SRC/GABRQ/ADCY3/HAP1/GNG2/GNB4/GPHN	21
KEGG	hsa00564	Glycerophospholipid metabolism	23/1853	98/8135	0.4743	0.6978	0.5564	ETNK2/PLB1/MBOAT1/PLD1/PLA2G4F/GPD1L/CHAT/LPIN1/LCLAT1/CDS1/PLA2G4A/CDIPT/DGKI/JMJD7-PLA2G4B/DGKZ/PNPLA7/PCYT1B/LPGAT1/DGKG/PISD/CHPT1/PLA2G2D/PLD4	23
KEGG	hsa05231	Choline metabolism in cancer	23/1853	98/8135	0.4743	0.6978	0.5564	PLD1/PDGFA/SLC44A1/MAPK3/PLA2G4F/EGFR/MAPK1/PIK3CB/MAPK10/KRAS/PLA2G4A/JUN/DGKI/PDGFB/JMJD7-PLA2G4B/DGKZ/SLC22A2/MAP2K1/PCYT1B/DGKG/CHPT1/MAPK9/MAPK8	23
KEGG	hsa04922	Glucagon signaling pathway	25/1853	107/8135	0.48	0.7032	0.5607	PDE3B/PLCB4/PLCB1/PPARGC1A/PYGB/G6PC3/SIK2/PRKAA2/PHKA1/PRKACB/CPT1C/CREB1/PPP3CB/GNAQ/ACACB/PRKAB1/PLCB2/PGAM2/GCGR/PRKAG1/SIK1/PPP3R2/PRKAB2/CREB3L4/CREB3L3	25
KEGG	hsa05132	Salmonella infection	57/1853	249/8135	0.5081	0.7373	0.5879	TLR5/IL6/DYNC2LI1/ELMO1/MAP2K6/SNX9/MAPK3/PAK1/CYCS/CYTH3/MAPK1/TNFSF10/PIK3CB/PTPRC/PYCARD/MAPK10/CYFIP2/KIF5C/MLKL/TCF7/RAB9B/EXOC7/MYLPF/MYL7/RAB7B/JUN/DYNLL2/AHNAK/TLR6/AHNAK2/PLEKHM2/FLNC/DYNLT3/VPS33A/NCKAP1L/TUBB1/IL1B/RIPK3/FYCO1/MAP2K1/RAB5C/ABI1/NLRP3/PFN2/BCL2/BAK1/VPS41/SNX33/MYD88/CASP3/DCTN5/FADD/TLR2/ELMO2/MAPK9/CYTH1/MAPK8	57
KEGG	hsa05416	Viral myocarditis	14/1853	60/8135	0.5094	0.7373	0.5879	ITGB2/CD55/CYCS/HLA-DQA1/SGCD/HLA-DQA2/DMD/HLA-DOA/CD40/ABL2/MYH7/CASP9/CASP3/CD40LG	14
KEGG	hsa05330	Allograft rejection	9/1853	38/8135	0.5099	0.7373	0.5879	IL12A/IL10/HLA-DQA1/IL4/HLA-DQA2/HLA-DOA/IL12B/CD40/CD40LG	9
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	30/1853	131/8135	0.521	0.7469	0.5956	SHC2/ITGB2/ICAM2/SHC3/MAPK3/PAK1/MAPK1/TNFSF10/PIK3CB/ULBP3/KLRC1/CD244/KLRC2/KLRD1/SH2D1B/SH2D1A/KRAS/KLRC3/PPP3CB/CSF2/ARAF/LCK/RAET1E/CD247/MAP2K1/SH3BP2/TYROBP/PPP3R2/CASP3/KIR2DS4	30
KEGG	hsa04923	Regulation of lipolysis in adipocytes	13/1853	56/8135	0.5211	0.7469	0.5956	ADCY8/PDE3B/ADORA1/NPR1/ADRB2/PIK3CB/ADCY4/PRKACB/GNAI1/ADCY3/PRKG2/NPY1R/PRKG1	13
KEGG	hsa04975	Fat digestion and absorption	10/1853	43/8135	0.5296	0.7559	0.6027	DGAT2/APOA4/APOA1/NPC1L1/MOGAT2/PNLIP/PLA2G2D/ACAT2/ABCA1/SCARB1	10
KEGG	hsa04658	Th1 and Th2 cell differentiation	21/1853	92/8135	0.5366	0.7626	0.6081	IL12RB1/IL12A/MAPK3/MAPK1/RBPJL/MAPK10/HLA-DQA1/RBPJ/JUN/IL4/STAT5A/PPP3CB/HLA-DQA2/LCK/CD247/HLA-DOA/IL12B/PPP3R2/STAT4/MAPK9/MAPK8	21
KEGG	hsa00770	Pantothenate and CoA biosynthesis	5/1853	21/8135	0.5395	0.7633	0.6086	ALDH3A2/ALDH1B1/ENPP3/ENPP1/ALDH2	5
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	44/1853	194/8135	0.5416	0.7633	0.6086	IL6/MAP2K6/MAPK3/CYCS/MAPK1/HCK/PIK3CB/MAPK10/PIK3R6/TCF7/CXCL2/FGF2/CCR1/KRAS/GNG12/JUN/CXCL1/CREB1/PDGFB/IKBKE/NFATC4/PPP3CB/ZFP36/CSF2/RCAN1/CDK6/TLR3/PREX1/PIK3R5/MAP2K1/SRC/EIF2AK2/BAK1/CD200R1/CASP9/MAP1LC3C/GNG2/PPP3R2/CASP3/GNB4/FADD/CDK4/MAPK9/MAPK8	44
KEGG	hsa00513	Various types of N-glycan biosynthesis	9/1853	39/8135	0.5446	0.7643	0.6094	MAN1C1/TUSC3/MAN1A1/HEXA/ALG13/ALG14/B4GALNT3/ALG11/FUT8	9
KEGG	hsa05135	Yersinia infection	31/1853	137/8135	0.5506	0.7695	0.6135	IL6/ELMO1/MAP2K6/MAPK3/ARHGEF7/RPS6KA6/IL10/MAPK1/PIK3CB/PYCARD/MAPK10/JUN/ROCK1/MEFV/LCK/GNAQ/WIPF1/IL1B/MAP2K1/SRC/NLRP3/GIT2/RPS6KA3/MYD88/CRKL/FCGR2A/BAIAP2/ELMO2/MAPK9/MAPK8/LIMK1	31
KEGG	hsa04918	Thyroid hormone synthesis	17/1853	75/8135	0.5545	0.7716	0.6153	ADCY8/PLCB4/PLCB1/ATP1A2/ATP1A3/ADCY4/PRKACB/CREB1/SLC5A5/ATP1B1/GNAQ/HSPA5/PLCB2/ADCY3/CREB3L4/FXYD2/CREB3L3	17
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1853	89/8135	0.5691	0.7888	0.6289	MAP2K6/MAPK3/EGFR/MAPK1/PIK3CB/BATF/KRAS/CD274/JUN/PDCD1/RASGRP1/PPP3CB/LCK/PTEN/CD247/MAP2K1/CSNK2A2/MYD88/PPP3R2/TLR2	20
KEGG	hsa04672	Intestinal immune network for IgA production	11/1853	49/8135	0.5776	0.7943	0.6333	IL6/TNFSF13B/IL10/HLA-DQA1/AICDA/TNFRSF17/IL4/HLA-DQA2/HLA-DOA/CD40/CD40LG	11
KEGG	hsa00010	Glycolysis / Gluconeogenesis	15/1853	67/8135	0.5782	0.7943	0.6333	GALM/ADH1A/ALDH3A2/ADH1C/ALDH1B1/G6PC3/ADH5/ACSS1/ALDH9A1/PGAM2/ALDH2/ALDH3A1/ADH4/ADPGK/ENO3	15
KEGG	hsa05310	Asthma	7/1853	31/8135	0.5803	0.7943	0.6333	IL10/HLA-DQA1/IL4/HLA-DQA2/HLA-DOA/CD40/CD40LG	7
KEGG	hsa04137	Mitophagy - animal	16/1853	72/8135	0.5909	0.8056	0.6423	MRAS/CALCOCO2/MITF/MAPK10/KRAS/RAB7B/JUN/SRC/CSNK2A2/TAX1BP1/MAP1LC3C/BCL2L13/RRAS2/FOXO3/MAPK9/MAPK8	16
KEGG	hsa03022	Basal transcription factors	10/1853	45/8135	0.5935	0.8058	0.6425	TAF3/TAF5L/TAF5/GTF2A1L/TAF1L/GTF2E2/GTF2A1/TAF15/GTF2IRD1/GTF2H4	10
KEGG	hsa01240	Biosynthesis of cofactors	34/1853	153/8135	0.5974	0.8079	0.6442	IDO1/LIAS/AK7/ALDH3A2/NME7/HPD/SHMT1/COX15/NMNAT3/ALDH1B1/AK3/CTPS2/CPOX/COQ7/AK5/COQ5/DHRS3/GCLM/VKORC1L1/RDH13/DHODH/PMM1/COX10/ALAD/ALDH2/LIPT1/ALAS2/IDO2/FECH/ADSL/NMNAT2/ALPI/TPK1/GPHN	34
KEGG	hsa00062	Fatty acid elongation	6/1853	27/8135	0.602	0.8096	0.6456	HADH/ELOVL4/ELOVL7/HSD17B12/HADHA/PPT1	6
KEGG	hsa04664	Fc epsilon RI signaling pathway	15/1853	68/8135	0.6036	0.8096	0.6456	MAP2K6/MAPK3/PLA2G4F/MAPK1/PIK3CB/MAPK10/KRAS/PLA2G4A/IL4/JMJD7-PLA2G4B/CSF2/GAB2/MAP2K1/MAPK9/MAPK8	15
KEGG	hsa00061	Fatty acid biosynthesis	4/1853	18/8135	0.6134	0.8195	0.6535	ACSL5/HSD17B8/ACACB/ACSL1	4
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/1853	223/8135	0.6404	0.8521	0.6794	HGF/PLD1/AS3MT/MAPK3/AKR1C1/GSTT1/EGFR/SDHA/MAPK1/PIK3CB/GSTA4/NDUFA10/MAPK10/CAT/EPHX2/NDUFS6/KRAS/JUN/CYP1A2/CYP2F1/GSTM4/NCF2/KEAP1/NOX1/ARAF/ND3/PTEN/GSTM5/GSTM3/PRKCD/GSTA2/NDUFS3/PPIF/MAP2K1/ABL2/SRC/PRKD1/LPO/GSTT2/SOD2/VDAC3/NDUFS2/ND2/FOXO3/NDUFA13/NDUFB11/SDHD/MAPK9/MAPK8	49
KEGG	hsa04145	Phagosome	33/1853	152/8135	0.6554	0.8672	0.6915	ATP6V0E2/THBS1/ITGB2/ITGA2/TCIRG1/SEC61A2/HLA-DQA1/ATP6V1E2/COLEC12/ATP6V1G3/RAB7B/NCF2/CTSS/SFTPD/HLA-DQA2/TLR6/CORO1A/ATP6AP1/FCGR2B/HLA-DOA/TUBB1/RAB5C/FCAR/CLEC4M/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1/FCGR2A/ITGB3/NCF4/TLR2/SCARB1	33
KEGG	hsa00140	Steroid hormone biosynthesis	13/1853	61/8135	0.6569	0.8672	0.6915	CYP3A5/AKR1C1/CYP3A4/CYP3A7/HSD17B8/CYP7A1/HSD17B7/HSD17B12/CYP1A2/HSD11B1L/CYP17A1/HSD11B1/HSD17B1	13
KEGG	hsa05340	Primary immunodeficiency	8/1853	38/8135	0.6622	0.8707	0.6943	IL7R/UNG/PTPRC/AICDA/LCK/CD40/RFXAP/CD40LG	8
KEGG	hsa05418	Fluid shear stress and atherosclerosis	30/1853	139/8135	0.665	0.871	0.6945	MAP2K6/PDGFA/GSTT1/MAP2K5/IL1R1/PIK3CB/GSTA4/MAPK10/PRKAA2/CDH5/JUN/GSTM4/NCF2/KEAP1/PDGFB/BMP4/NOX1/MMP9/EDN1/GSTM5/GSTM3/IL1B/GSTA2/SRC/NOS3/BCL2/GSTT2/ITGB3/MAPK9/MAPK8	30
KEGG	hsa00860	Porphyrin metabolism	9/1853	43/8135	0.6718	0.8762	0.6986	HEPH/COX15/CPOX/CP/COX10/ALAD/BLVRB/ALAS2/FECH	9
KEGG	hsa05170	Human immunodeficiency virus 1 infection	46/1853	212/8135	0.6742	0.8762	0.6986	SAMHD1/MAP2K6/TNFRSF1B/APOBEC3D/MAPK3/PAK1/CYCS/APOBEC3C/MAPK1/PIK3CB/APOBEC3G/APOBEC3H/MAPK10/PAK2/APOBEC3F/WEE1/KRAS/GNG12/JUN/NFATC4/CCNB3/PPP3CB/GNAI1/ATR/AP1M1/GNAQ/CCNB1/CD247/CDC25C/MAP2K1/BCL2/BAK1/BST2/MYD88/CASP9/CRKL/GNG2/PPP3R2/CASP3/GNB4/LIMK2/FADD/TLR2/MAPK9/MAPK8/LIMK1	46
KEGG	hsa04971	Gastric acid secretion	16/1853	76/8135	0.6839	0.8853	0.7059	ADCY8/PLCB4/PLCB1/ATP1A2/KCNJ10/KCNJ2/ATP1A3/ADCY4/PRKACB/ATP1B1/GNAI1/SLC26A7/GNAQ/PLCB2/ADCY3/SST	16
KEGG	hsa04142	Lysosome	28/1853	132/8135	0.6997	0.9001	0.7177	NAGA/CLN3/TCIRG1/SLC11A1/CTSO/ARSG/CLTCL1/SMPD1/CTSS/IDS/AP1M1/CTSH/HEXA/CTSG/ATP6AP1/FUCA1/DMXL2/PPT1/ARSA/DMXL1/SLC17A5/NAPSA/ATP6V0A1/GGA2/ABCB9/CD68/ACP5/NEU1	28
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1853	20/8135	0.7007	0.9001	0.7177	CHSY3/CHST14/CSGALNACT2/CSGALNACT1	4
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	104/1853	476/8135	0.7082	0.9063	0.7227	IL6/GRIN2A/WNT9A/PLCB4/RAB8A/PLCB1/MAP2K6/WNT16/TNFRSF1B/WNT11/MAPK3/DVL2/WNT10B/WNT2/GRIA3/CYCS/SDHA/DNAI1/MAPK1/GRIA1/CHRM1/DNAL1/NEFL/UBE2L6/SPG11/NDUFA10/APC/MAPK10/STX1A/UBE2G1/KIF5C/GRM1/TANK/DKK4/CAT/ATF6/IFT57/AGER/NDUFS6/KRAS/GRIN2C/DNAL4/FIG4/BDNF/LRRK2/AXIN1/PPP3CB/DLG4/TRPC3/NOX1/ARAF/SNCA/WNT4/HIP1/ND3/GNAQ/FRAT1/CSF1/MAP3K10/FZD1/HSPA5/FZD8/CDK5R1/SPTBN2/TUBB1/IL1B/PLCB2/ERN1/GRM5/NDUFS3/PPIF/MAP2K1/ATXN3/CSNK2A2/CASP12/RAB39B/BCL2/BAK1/HAP1/UBA7/DNAI2/CASP9/MAP1LC3C/PPP3R2/CASP3/APC2/PSMC5/UBE2G2/VDAC3/NDUFS2/ND2/WNT1/DCTN5/NDUFA13/DNAH5/PSEN2/NDUFB11/FADD/CHRNA7/SDHD/DNAH3/MAPK9/UBE2J2/MAPK8	104
KEGG	hsa05169	Epstein-Barr virus infection	43/1853	202/8135	0.7214	0.9196	0.7333	IL6/CCNA1/MAP2K6/CYCS/OAS2/PIK3CB/CDK2/RBPJL/MAPK10/HLA-DQA1/RBPJ/OAS1/CCNA2/JUN/CCNE1/FCER2/IKBKE/HLA-DQA2/CDK6/CCNE2/SKP2/CD247/HLA-DOA/CD40/HDAC1/SAP30L/EIF2AK2/OAS3/BCL2/BAK1/GADD45G/MYD88/CASP9/CASP3/CXCL10/PSMC5/GADD45B/FADD/CCND2/TLR2/CDK4/MAPK9/MAPK8	43
KEGG	hsa00360	Phenylalanine metabolism	3/1853	16/8135	0.7419	0.9421	0.7512	HPD/MAOB/ALDH3A1	3
KEGG	hsa04622	RIG-I-like receptor signaling pathway	14/1853	70/8135	0.7537	0.9499	0.7574	IL12A/IFIH1/MAPK10/TANK/IKBKE/CASP10/IL12B/TRIM25/PIN1/IFNW1/CXCL10/FADD/MAPK9/MAPK8	14
KEGG	hsa05230	Central carbon metabolism in cancer	14/1853	70/8135	0.7537	0.9499	0.7574	FGFR2/MAPK3/EGFR/MAPK1/PIK3CB/GLS/KRAS/PTEN/FGFR1/ERBB2/PGAM2/MAP2K1/NTRK3/KIT	14
KEGG	hsa04064	NF-kappa B signaling pathway	21/1853	104/8135	0.7707	0.9631	0.768	TNFRSF11A/BCL2A1/TNFSF13B/IL1R1/CCL21/CXCL2/CXCL1/PARP1/CARD10/LCK/CARD11/IL1B/CD40/CSNK2A2/TRIM25/BCL2/GADD45G/MYD88/CCL4/GADD45B/CD40LG	21
KEGG	hsa01250	Biosynthesis of nucleotide sugars	7/1853	37/8135	0.7707	0.9631	0.768	CMAS/GALK2/GNE/PMM1/GFPT1/GALT/GFPT2	7
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/1853	22/8135	0.7728	0.9631	0.768	DHDDS/IDI1/ACAT2/FNTA	4
KEGG	hsa04940	Type I diabetes mellitus	8/1853	43/8135	0.7957	0.9875	0.7874	ICA1/IL12A/HLA-DQA1/HLA-DQA2/GAD1/HLA-DOA/IL12B/IL1B	8
KEGG	hsa05203	Viral carcinogenesis	42/1853	204/8135	0.7983	0.9875	0.7874	CCNA1/MAPK3/MAPK1/PIK3CB/EGR3/KAT2B/CDK2/RBPJL/RBPJ/RBL1/SRF/KRAS/CCNA2/JUN/CCNE1/HDAC3/ACTN1/PRKACB/CREB1/STAT5A/GTF2A1L/CDK6/CCNE2/GTF2E2/HDAC9/SKP2/YWHAG/HDAC11/HDAC1/SRC/GTF2A1/EIF2AK2/BAK1/CASP3/CREB3L4/GTF2H4/VDAC3/CREB3L3/CCND2/CDK4/PMAIP1/DNAJA3	42
KEGG	hsa03430	Mismatch repair	4/1853	23/8135	0.8034	0.9901	0.7895	POLD2/RFC1/RFC3/EXO1	4
KEGG	hsa04612	Antigen processing and presentation	15/1853	78/8135	0.8109	0.9932	0.792	KLRC1/HLA-DQA1/KLRC2/KLRD1/KLRC3/CTSS/CREB1/HLA-DQA2/HSPA6/PSME1/HSPA5/HLA-DOA/RFXAP/KIR2DS4/KIR2DL4	15
KEGG	hsa00511	Other glycan degradation	3/1853	18/8135	0.8132	0.9932	0.792	HEXA/FUCA1/NEU1	3
KEGG	hsa04512	ECM-receptor interaction	17/1853	88/8135	0.8165	0.9932	0.792	THBS1/LAMA3/COL9A3/ITGB8/ITGA2/LAMC2/FREM1/AGRN/COL4A1/SPP1/COL4A5/CD47/ITGA9/LAMB3/ITGA8/ITGA10/ITGB3	17
KEGG	hsa03460	Fanconi anemia pathway	10/1853	54/8135	0.8178	0.9932	0.792	REV3L/ERCC4/ATR/FANCC/FANCD2/BRCA1/EME1/MUS81/BRIP1/ATRIP	10
KEGG	hsa04744	Phototransduction	5/1853	29/8135	0.8237	0.9954	0.7937	RGS9/RHO/PDE6G/GUCA1B/GRK1	5
KEGG	hsa03450	Non-homologous end-joining	2/1853	13/8135	0.8323	0.9954	0.7937	POLL/NHEJ1	2
KEGG	hsa05415	Diabetic cardiomyopathy	41/1853	203/8135	0.8345	0.9954	0.7937	PLCB4/PLCB1/AGTR1/ACE/SDHA/PIK3CB/NDUFA10/MAPK10/AGER/NDUFS6/REN/TGFB3/NCF2/PARP1/SMAD2/TGFBR2/PPP1CB/CMA1/MMP9/ND3/PTEN/PPP1CC/PDK4/PRKCD/TGFBR1/GFPT1/PLCB2/NDUFS3/PPIF/NOS3/CPT2/VDAC3/NDUFS2/ND2/NDUFA13/NDUFB11/GFPT2/NCF4/SDHD/MAPK9/MAPK8	41
KEGG	hsa03320	PPAR signaling pathway	14/1853	75/8135	0.8393	0.9954	0.7937	CYP27A1/ACSL5/SCP2/CYP7A1/APOA1/PPARG/ADIPOQ/CPT1C/FADS2/ACOX3/MMP1/CPT2/SORBS1/ACSL1	14
KEGG	hsa00531	Glycosaminoglycan degradation	3/1853	19/8135	0.8421	0.9954	0.7937	HPSE/IDS/HEXA	3
KEGG	hsa05171	Coronavirus disease - COVID-19	47/1853	232/8135	0.8433	0.9954	0.7937	MASP1/IL6/C5/AGTR1/RPL28/IL12A/MAPK3/IFIH1/CFB/ACE/EGFR/MAPK1/OAS2/PIK3CB/MAPK10/RPL22/OAS1/TMPRSS2/F13A1/C9/JUN/IL6R/C2/MX1/IKBKE/CSF2/CFD/TLR3/RPL27A/IL12B/IL1B/C5AR1/NLRP3/EIF2AK2/C1QC/OAS3/MMP1/MYD88/CSF3/FCGR2A/MMP3/CXCL10/C1QB/MX2/TLR2/MAPK9/MAPK8	47
KEGG	hsa04144	Endocytosis	51/1853	251/8135	0.8464	0.9954	0.7937	PARD6B/PLD1/GRK5/DNM1/RAB8A/FGFR2/PARD6A/SH3GL2/EGFR/BIN1/CYTH3/PSD3/KIF5C/VTA1/FOLR3/RAB4A/FOLR1/ARAP2/LDLR/VPS26B/CHMP5/RAB31/CLTCL1/AMPH/ARAP1/HSPA6/SMAD2/TGFBR2/ARRB1/CHMP7/WIPF1/DAB2/FGFR4/TGFBR1/FOLR2/RAB5C/SRC/VPS37C/PDCD6IP/RAB11FIP1/GIT2/ARRB2/ARFGAP2/EHD1/SMAP2/PIP5KL1/SNX1/ASAP1/GRK1/PARD6G/CYTH1	51
KEGG	hsa00020	Citrate cycle (TCA cycle)	5/1853	30/8135	0.8464	0.9954	0.7937	SDHA/PC/SUCLG2/CS/SDHD	5
KEGG	hsa00053	Ascorbate and aldarate metabolism	5/1853	30/8135	0.8464	0.9954	0.7937	ALDH3A2/ALDH1B1/KL/ALDH9A1/ALDH2	5
KEGG	hsa03440	Homologous recombination	7/1853	41/8135	0.8568	0.9979	0.7957	POLD2/BARD1/BRCA1/XRCC3/EME1/MUS81/BRIP1	7
KEGG	hsa00500	Starch and sucrose metabolism	6/1853	36/8135	0.8608	0.9979	0.7957	PYGB/MGAM/G6PC3/ENPP3/ENPP1/PGM2L1	6
KEGG	hsa04217	Necroptosis	31/1853	159/8135	0.8634	0.9979	0.7957	PYGB/PLA2G4F/IL33/GLUL/TNFSF10/PYCARD/MAPK10/GLUD2/MLKL/CHMP5/PLA2G4A/SMPD1/STAT5A/JMJD7-PLA2G4B/PARP1/TLR3/CHMP7/IL1B/RIPK3/NLRP3/EIF2AK2/BCL2/GLUD1/VDAC3/ZBP1/RBCK1/FADD/STAT4/DNM1L/MAPK9/MAPK8	31
KEGG	hsa00052	Galactose metabolism	5/1853	31/8135	0.8667	0.9979	0.7957	GALM/MGAM/G6PC3/AKR1B10/GALT	5
KEGG	hsa00670	One carbon pool by folate	3/1853	20/8135	0.8671	0.9979	0.7957	SHMT1/ALDH1L2/MTHFR	3
KEGG	hsa03420	Nucleotide excision repair	8/1853	47/8135	0.8705	0.9979	0.7957	POLD2/ERCC4/RFC1/RFC3/POLE/XPA/GTF2H4/XPC	8
KEGG	hsa05332	Graft-versus-host disease	7/1853	42/8135	0.8737	0.9979	0.7957	IL6/KLRC1/HLA-DQA1/KLRD1/HLA-DQA2/HLA-DOA/IL1B	7
KEGG	hsa00790	Folate biosynthesis	4/1853	26/8135	0.8754	0.9979	0.7957	AKR1B10/MOCOS/ALPI/GPHN	4
KEGG	hsa04950	Maturity onset diabetes of the young	4/1853	26/8135	0.8754	0.9979	0.7957	NR5A2/ONECUT1/MNX1/PDX1	4
KEGG	hsa04714	Thermogenesis	46/1853	232/8135	0.8794	0.9991	0.7966	ADCY8/SLC25A29/ACSL5/PPARGC1A/SMARCD2/NPR1/ZNF516/RPS6KA6/SDHA/PRDM16/COX15/NDUFA10/PRKAA2/PPARG/DPF1/NDUFS6/KRAS/SMARCE1/ADCY4/PRKACB/CPT1C/CREB1/DPF3/NPPB/ND3/FGFR1/PRKAB1/COX10/NDUFS3/COX11/ADCY3/PRKG2/SMARCD3/RPS6KA3/PRKAG1/PRKAB2/CREB3L4/CPT2/PRKG1/NDUFS2/ND2/CREB3L3/NDUFA13/NDUFB11/SDHD/ACSL1	46
KEGG	hsa05131	Shigellosis	49/1853	247/8135	0.8854	1	0.7974	TLR5/ELMO1/RPS6KA5/PLCB4/PLCB1/MAPK3/CYCS/CALCOCO2/EGFR/IL1R1/CYTH3/MAPK1/PIK3CB/PYCARD/MAPK10/PRKCE/MYLPF/MYL7/JUN/ROCK1/PLCE1/ACTN1/TIFA/CSF2/PLCD3/PRKCD/ATG16L1/IL1B/PLCB2/RRAGB/TLN2/SRC/NLRP3/PFN2/BCL2/FNBP1L/FNBP1/UBE2D4/MYD88/UBE2D1/MAP1LC3C/CRKL/RBCK1/FOXO3/UBE2V1/ELMO2/MAPK9/CYTH1/MAPK8	49
KEGG	hsa05163	Human cytomegalovirus infection	44/1853	225/8135	0.8958	1	0.7974	ADCY8/IL6/PLCB4/PLCB1/MAP2K6/MAPK3/CYCS/EGFR/IL1R1/PTGER2/MAPK1/PIK3CB/ELK1/CCR1/KRAS/GNG12/ROCK1/IL6R/ADCY4/PRKACB/CREB1/NFATC4/PPP3CB/GNAI1/CDK6/GNAQ/IL1B/PLCB2/MAP2K1/SRC/ADCY3/BAK1/CASP9/CRKL/GNG2/PPP3R2/CASP3/CREB3L4/GNB4/CREB3L3/CCL4/ITGB3/FADD/CDK4	44
KEGG	hsa05034	Alcoholism	36/1853	187/8135	0.8964	1	0.7974	CAMKK1/GRIN2A/SHC2/SHC3/MAPK3/MAPK1/GRIN3A/ADORA2B/KRAS/GNG12/GRIN2C/HDAC3/CAMKK2/BDNF/PRKACB/CREB1/SLC29A3/GNAI1/PKIA/PPP1CB/ARAF/HDAC9/DRD2/PPP1CC/MAOB/SLC18A2/HDAC11/CAMK4/HDAC1/MAP2K1/ADORA2A/GNG2/CREB3L4/GNB4/CREB3L3/SLC29A2	36
KEGG	hsa00510	N-Glycan biosynthesis	8/1853	50/8135	0.9105	1	0.7974	MAN1C1/GANAB/TUSC3/MAN1A1/ALG13/ALG14/ALG11/FUT8	8
KEGG	hsa00040	Pentose and glucuronate interconversions	5/1853	34/8135	0.9144	1	0.7974	DHDH/KL/DCXR/AKR1B10/CRYL1	5
KEGG	hsa04260	Cardiac muscle contraction	15/1853	87/8135	0.9178	1	0.7974	ATP1A2/SLC8A1/CACNB2/CACNG4/ATP1A3/ATP1B1/CACNA2D3/TPM3/CACNA2D1/TNNT2/ACTC1/CACNG5/MYH7/HRC/FXYD2	15
KEGG	hsa00450	Selenocompound metabolism	2/1853	17/8135	0.9259	1	0.7974	TXNRD3/INMT	2
KEGG	hsa05010	Alzheimer disease	76/1853	384/8135	0.9339	1	0.7974	IL6/GRIN2A/WNT9A/PLCB4/PLCB1/WNT16/WNT11/MAPK3/DVL2/WNT10B/WNT2/CYCS/SDHA/MAPK1/PIK3CB/CHRM1/NDUFA10/APC/MAPK10/KIF5C/DKK4/ATF6/AGER/APOE/NDUFS6/KRAS/RTN3/GRIN2C/SLC39A8/AXIN1/PPP3CB/MME/NOX1/ARAF/SNCA/WNT4/ND3/GNAQ/FRAT1/CSF1/FZD1/SLC39A14/FZD8/CDK5R1/TUBB1/IL1B/PLCB2/ERN1/SLC39A1/GRM5/NDUFS3/PPIF/MAP2K1/EIF2AK2/CSNK2A2/CASP12/CASP9/SLC39A10/PPP3R2/CASP3/APBB1/APC2/PSMC5/VDAC3/NDUFS2/ND2/WNT1/NDUFA13/PSEN2/NDUFB11/FADD/CHRNA7/SDHD/MAPK9/BACE2/MAPK8	76
KEGG	hsa03030	DNA replication	5/1853	36/8135	0.9372	1	0.7974	POLD2/RFC1/RFC3/RNASEH2B/POLE	5
KEGG	hsa04932	Non-alcoholic fatty liver disease	28/1853	155/8135	0.9375	1	0.7974	IL6/CYCS/SDHA/PIK3CB/NDUFA10/MAPK10/MLXIPL/PRKAA2/PPARG/CEBPA/NDUFS6/JUN/IL6R/ADIPOQ/PRKAB1/IL1B/ERN1/NDUFS3/PRKAG1/PRKAB2/CASP3/NDUFS2/NDUFA13/LEPR/NDUFB11/SDHD/MAPK9/MAPK8	28
KEGG	hsa05320	Autoimmune thyroid disease	8/1853	53/8135	0.9395	1	0.7974	IL10/HLA-DQA1/CTLA4/IL4/HLA-DQA2/HLA-DOA/CD40/CD40LG	8
KEGG	hsa05017	Spinocerebellar ataxia	25/1853	143/8135	0.9513	1	0.7974	GRIN2A/PLCB4/PLCB1/GRIA3/CYCS/PIK3CB/GRIN3A/GRIA1/RBPJL/MAPK10/RBPJ/GRM1/GRIN2C/TRPC3/GNAQ/SPTBN2/PLCB2/ERN1/PPIF/ATXN3/PSMC5/VDAC3/KCND3/MAPK9/MAPK8	25
KEGG	hsa04662	B cell receptor signaling pathway	13/1853	82/8135	0.9539	1	0.7974	MAPK3/MAPK1/PIK3CB/CD79B/KRAS/JUN/PPP3CB/LILRB3/CARD11/FCGR2B/MAP2K1/LILRA1/PPP3R2	13
KEGG	hsa04136	Autophagy - other	4/1853	32/8135	0.9541	1	0.7974	PPP2CB/ATG16L1/IGBP1/ATG4C	4
KEGG	hsa00190	Oxidative phosphorylation	23/1853	134/8135	0.9559	1	0.7974	ATP6V0E2/CYCS/SDHA/COX15/TCIRG1/NDUFA10/ATP6V1E2/NDUFS6/ATP6V1G3/ND3/ATP6AP1/COX10/NDUFS3/COX11/ATP6V1F/ATP6V1G2/ATP6V1C1/ATP6V0A1/NDUFS2/ND2/NDUFA13/NDUFB11/SDHD	23
KEGG	hsa05016	Huntington disease	58/1853	306/8135	0.9572	1	0.7974	PLCB4/PLCB1/PPARGC1A/GRIA3/CYCS/SDHA/DNAI1/GRIA1/DNAL1/TGM2/NDUFA10/KCNJ10/MAPK10/STX1A/KIF5C/SLC1A3/POLR2E/PPARG/IFT57/NDUFS6/DNAL4/CLTCL1/BDNF/CREB1/DLG4/HIP1/ND3/GNAQ/MAP3K10/POLR2J/TUBB1/PLCB2/HDAC1/ERN1/GRM5/NDUFS3/PPIF/POLR2K/HAP1/DNAI2/CASP9/SOD2/CASP3/CREB3L4/SLC1A2/PSMC5/VDAC3/NDUFS2/ND2/CREB3L3/DCTN5/NDUFA13/DNAH5/NDUFB11/SDHD/DNAH3/MAPK9/MAPK8	58
KEGG	hsa03018	RNA degradation	12/1853	79/8135	0.9651	1	0.7974	BTG4/PABPC4L/NUDT16/PABPC4/DIS3/XRN2/CNOT6L/BTG3/PNLDC1/ENO3/BTG1/TTC37	12
KEGG	hsa04120	Ubiquitin mediated proteolysis	24/1853	142/8135	0.9665	1	0.7974	RHOBTB1/FBXO4/UBE2L6/UBE2G1/CUL3/MID1/PIAS3/HERC4/KEAP1/UBE2O/UBE2E2/UBE2U/SKP2/UBE2S/BRCA1/UBE2E3/UBA7/UBE2D4/UBE2R2/UBE2D1/UBE2G2/UBA2/UBE2J2/HERC2	24
KEGG	hsa03013	Nucleocytoplasmic transport	17/1853	108/8135	0.9734	1	0.7974	RAE1/SNUPN/IPO5/GLE1/RANBP17/THOC1/IPO8/UPF3A/SRRM1/MAGOHB/THOC6/IPO7/NCBP2/DDX19B/NUP160/RANGAP1/IPO11	17
KEGG	hsa05100	Bacterial invasion of epithelial cells	11/1853	77/8135	0.9776	1	0.7974	SHC2/ELMO1/DNM1/SHC3/PIK3CB/CLTCL1/CTNNA3/SRC/GAB1/CRKL/ELMO2	11
KEGG	hsa00030	Pentose phosphate pathway	3/1853	30/8135	0.9797	1	0.7974	PGD/PGLS/GLYCTK	3
KEGG	hsa00270	Cysteine and methionine metabolism	6/1853	51/8135	0.9855	1	0.7974	APIP/GCLM/AHCYL1/SDSL/SMS/TST	6
KEGG	hsa01230	Biosynthesis of amino acids	10/1853	75/8135	0.9864	1	0.7974	CPS1/SHMT1/GLUL/PC/PYCR1/SDSL/PGAM2/CS/ENO3/ASNS	10
KEGG	hsa00051	Fructose and mannose metabolism	3/1853	33/8135	0.9889	1	0.7974	KHK/PMM1/AKR1B10	3
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/1853	19/8135	0.9927	1	0.7974	CS	1
KEGG	hsa05020	Prion disease	46/1853	273/8135	0.9942	1	0.7974	IL6/GRIN2A/C5/MAPK3/CYCS/SDHA/MAPK1/PIK3CB/GRIN3A/NDUFA10/MAPK10/KIF5C/C9/NDUFS6/GRIN2C/NCF2/PRKACB/CREB1/PPP3CB/HSPA6/ND3/HSPA5/PRKCD/TUBB1/IL1B/NDUFS3/PPIF/CSNK2A2/C1QC/CASP12/CASP9/PPP3R2/CASP3/CREB3L4/PSMC5/VDAC3/NDUFS2/ND2/CREB3L3/NDUFA13/C1QB/NDUFB11/NCF4/SDHD/MAPK9/MAPK8	46
KEGG	hsa03050	Proteasome	4/1853	46/8135	0.9967	1	0.7974	PSME1/PSMB8/PSMB9/PSMC5	4
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/1853	23/8135	0.9974	1	0.7974	FKTN	1
KEGG	hsa05012	Parkinson disease	42/1853	266/8135	0.9984	1	0.7974	CYCS/SDHA/UBE2L6/NDUFA10/MAPK10/UBE2G1/KIF5C/ATF6/NDUFS6/SLC39A8/LRRK2/PRKACB/KEAP1/GNAI1/SNCA/DRD2/ND3/SLC39A14/HSPA5/MAOB/SLC18A2/TUBB1/ERN1/SLC39A1/NDUFS3/PPIF/ADORA2A/UBA7/CASP9/SLC39A10/CASP3/PSMC5/UBE2G2/VDAC3/NDUFS2/ND2/NDUFA13/NDUFB11/SDHD/MAPK9/UBE2J2/MAPK8	42
KEGG	hsa04066	HIF-1 signaling pathway	13/1853	109/8135	0.9988	1	0.7974	IL6/MAPK3/EGFR/MAPK1/PIK3CB/IL6R/EDN1/ERBB2/MAP2K1/MKNK2/NOS3/BCL2/ENO3	13
KEGG	hsa04613	Neutrophil extracellular trap formation	27/1853	190/8135	0.999	1	0.7974	ITGB2/C5/PLCB4/PLCB1/MAPK3/MAPK1/PIK3CB/AGER/HDAC3/PADI4/NCF2/AZU1/SELPLG/HDAC9/CTSG/HDAC11/PLCB2/HDAC1/C5AR1/PPIF/MAP2K1/SRC/FCGR2A/VDAC3/ITGB3/NCF4/TLR2	27
KEGG	hsa05168	Herpes simplex virus 1 infection	82/1853	495/8135	0.9998	1	0.7974	IL6/C5/CARD9/IL12A/IFIH1/CYCS/ZNF221/OAS2/PIK3CB/ZNF282/ZNF230/ZNF257/ZNF19/HLA-DQA1/OAS1/ZFP57/ZNF546/ZNF670/ZNF227/ZNF780A/ZNF440/HCFC1/ZNF519/ZNF454/IKBKE/ZNF790/HLA-DQA2/ZNF2/ZNF114/ZNF234/ZNF311/ZNF766/PPP1CB/TLR3/ZNF562/PPP1CC/ZNF599/EIF2AK1/ZNF853/ZNF559/ZNF415/ZNF17/ZNF610/HLA-DOA/IL12B/IL1B/ZNF443/SRC/ZFP1/EIF2AK2/ZNF773/RNASEL/ZNF436/OAS3/ZNF552/BCL2/BAK1/ZNF34/ZNF33A/BST2/ZNF792/ZNF765/ZNF473/ZNF543/ZNF630/MYD88/CASP9/ZNF214/ZNF286A/CASP3/ZNF382/ZNF540/ZNF160/ZNF669/ITGB3/ZNF157/FADD/ZNF267/ZNF101/TLR2/TNFRSF14/ZNF589	82
KEGG	hsa05322	Systemic lupus erythematosus	15/1853	136/8135	0.9999	1	0.7974	GRIN2A/C5/IL10/HLA-DQA1/C9/C2/ACTN1/HLA-DQA2/CTSG/HLA-DOA/CD40/C1QC/FCGR2A/C1QB/CD40LG	15
KEGG	hsa03040	Spliceosome	16/1853	147/8135	0.9999	1	0.7974	RBMX/THOC1/PRPF31/DHX15/MAGOHB/HSPA6/RBM22/SMNDC1/DHX16/CRNKL1/CHERP/NCBP2/PPIL1/TRA2A/SLU7/CDC5L	16
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	10/1853	109/8135	0.9999	1	0.7974	MDN1/UTP6/XRN2/NOB1/GNL3L/RBM28/CSNK2A2/RPP38/RPP30/RIOK2	10
KEGG	hsa05014	Amyotrophic lateral sclerosis	54/1853	364/8135	1	1	0.7974	GRIN2A/CHCHD10/RAE1/RAB8A/MAP2K6/TNFRSF1B/GLE1/CYCS/SDHA/DNAI1/GRIA1/DNAL1/NEFL/SPG11/NDUFA10/KIF5C/TANK/CAT/ATF6/NDUFS6/GRIN2C/DNAL4/FIG4/PPP3CB/ND3/HSPA5/ERBB4/TUBB1/ERN1/NDUFS3/PFN2/CASP12/RAB39B/BCL2/HAP1/UBQLN4/DNAI2/CASP9/MAP1LC3C/PPP3R2/NUP160/CASP3/SLC1A2/PSMC5/NDUFS2/ND2/DCTN5/NDUFA13/DNAH5/ANXA11/NDUFB11/NRG1/SDHD/DNAH3	54
KEGG	hsa05206	MicroRNAs in cancer	42/1853	310/8135	1	1	0.7974	THBS1/RPS6KA5/PDGFA/MAPK3/EGFR/MAPK1/PIK3CB/APC/CCNG1/BMF/SLC45A3/PRKCE/GLS/KRAS/CCNE1/ROCK1/CDC25B/PDGFB/ABCC1/CDK6/ABCB1/CCNE2/ZFPM2/MMP9/PTEN/PDCD4/ERBB2/CDC25C/HDAC1/BRCA1/MAP2K1/DICER1/BCL2/BAK1/BCL2L2/HOXD10/CRKL/ST14/CASP3/APC2/ITGB3/CCND2	42
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	2/1853	66/8135	1	1	0.7974	CARS2/WARS2	2
KEGG	hsa03010	Ribosome	10/1853	158/8135	1	1	0.7974	RPL28/RPL22/MRPS16/MRPL24/RPL27A/MRPL9/MRPS6/MRPS5/MRPL28/MRPL11	10
KEGG	hsa04740	Olfactory transduction	35/1853	440/8135	1	1	0.7974	RGS2/CNGA3/SLC8A1/OR6M1/OR2C1/OR10J5/PDE1B/OR10P1/OR6K2/OR1C1/OR5F1/OR3A2/OR10H4/PRKACB/OR56B1/ANO2/SLC24A4/OR51G1/OR10C1/OR7A5/ARRB1/OR12D3/OR10T2/OR6Y1/ADCY3/PRKG2/OR52B2/NCALD/ARRB2/OR4X2/OR2A7/PRKG1/OR7A10/PDE2A/OR5V1	35