ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count BP GO:0002683 negative regulation of immune system process 38/689 463/18670 3.867e-06 0.007085 0.006574 DUSP1/GBP1/IRF1/TNFAIP3/ZFP36/MUL1/PARP14/TRAFD1/PRDX2/LAX1/RIOK3/ARG2/SERPING1/PHPT1/C5/GPATCH3/GCSAM/FBXW7/TSC22D3/PELI1/HES1/CEACAM1/PDCD1LG2/THBS1/TLR9/CNR2/NR1D1/PDE5A/TWSG1/FCRLB/H4C8/TRIM38/IHH/TRIB1/LOXL3/CCL28/BTN2A2/N4BP2L2 38 BP GO:0002832 negative regulation of response to biotic stimulus 10/689 47/18670 6.598e-06 0.007085 0.006574 TNFAIP3/MUL1/PRDX2/RIOK3/ARG2/GPATCH3/CEACAM1/TRIM38/TRIB1/SIGIRR 10 BP GO:0043900 regulation of multi-organism process 34/689 405/18670 7.708e-06 0.007085 0.006574 PDE3A/STAT1/CXCL8/GTF2F2/TRAF3/TRIM26/TNFAIP3/ZFP36/MUL1/ZNF502/DDX58/PRDX2/RIOK3/RIPK2/ARG2/RAD23A/GPATCH3/TBK1/LAMP3/STAU1/FAM111A/ZC3HAV1/CLEC7A/CAV2/AGO2/PDE5A/ISG20/PABPC1/STOM/TRIM38/TRIB1/IL15/SIGIRR/DDX60 34 BP GO:0032648 regulation of interferon-beta production 10/689 48/18670 8.062e-06 0.007085 0.006574 TRAF3/IRF1/IFIH1/DDX58/RIOK3/RIPK2/TBK1/TLR9/POLR3G/TRIM38 10 BP GO:0051607 defense response to virus 24/689 238/18670 8.573e-06 0.007085 0.006574 PMAIP1/GBP1/STAT1/NT5C3A/TRAF3/IRF1/STAT2/TNFAIP3/IFIH1/MUL1/DDX58/RIOK3/GPATCH3/TBK1/FAM111A/SPON2/TLR9/ZC3HAV1/POLR3G/ISG20/TRIM38/IFIT3/IL15/DDX60 24 BP GO:0032728 positive regulation of interferon-beta production 8/689 30/18670 9.401e-06 0.007085 0.006574 IRF1/IFIH1/DDX58/RIOK3/RIPK2/TBK1/TLR9/POLR3G 8 BP GO:1903034 regulation of response to wounding 20/689 179/18670 1.061e-05 0.007085 0.006574 PHLDB2/TNFAIP3/PLG/PRDX2/SERPING1/RTN4RL1/KLF4/SERPINC1/CEACAM1/GP1BA/MYLK/THBS1/HRAS/CLEC7A/SELP/SYTL4/VIL1/RTN4R/PRKCE/NOS3 20 BP GO:0032608 interferon-beta production 10/689 50/18670 1.185e-05 0.007085 0.006574 TRAF3/IRF1/IFIH1/DDX58/RIOK3/RIPK2/TBK1/TLR9/POLR3G/TRIM38 10 BP GO:0002831 regulation of response to biotic stimulus 17/689 139/18670 1.475e-05 0.007843 0.007278 STAT1/TRAF3/TNFAIP3/MUL1/DDX58/PRDX2/RIOK3/RIPK2/ARG2/GPATCH3/TBK1/CEACAM1/TRIM38/TRIB1/IL15/SIGIRR/DDX60 17 BP GO:0006809 nitric oxide biosynthetic process 12/689 77/18670 2.364e-05 0.01131 0.0105 PTGS2/GCH1/ICAM1/PKD2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 12 BP GO:0009615 response to virus 28/689 326/18670 3.215e-05 0.0134 0.01243 PMAIP1/GBP1/STAT1/NT5C3A/TRAF3/IRF1/STAT2/TNFAIP3/IFIH1/MUL1/DDX58/RIOK3/CLU/GPATCH3/TBK1/FAM111A/SPON2/PIM2/TLR9/ODC1/ZC3HAV1/HMGA1/POLR3G/ISG20/TRIM38/IFIT3/IL15/DDX60 28 BP GO:0061041 regulation of wound healing 17/689 148/18670 3.36e-05 0.0134 0.01243 PHLDB2/TNFAIP3/PLG/PRDX2/SERPING1/SERPINC1/CEACAM1/GP1BA/MYLK/THBS1/HRAS/CLEC7A/SELP/SYTL4/VIL1/PRKCE/NOS3 17 BP GO:0032102 negative regulation of response to external stimulus 30/689 365/18670 3.892e-05 0.01433 0.01329 PHLDB2/DUSP1/SOCS3/METRNL/TNFAIP3/MUL1/MVK/PLG/PRDX2/RIOK3/ARG2/SERPING1/RTN4RL1/KLF4/C5/GPATCH3/CEACAM1/MIR26A1/GP1BA/THBS1/SPX/CNR2/LEP/NR1D1/RTN4R/AIF1/TRIM38/NOS3/TRIB1/SIGIRR 30 BP GO:0046209 nitric oxide metabolic process 12/689 82/18670 4.506e-05 0.0154 0.01429 PTGS2/GCH1/ICAM1/PKD2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 12 BP GO:2001057 reactive nitrogen species metabolic process 12/689 85/18670 6.469e-05 0.01956 0.01815 PTGS2/GCH1/ICAM1/PKD2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 12 BP GO:1903037 regulation of leukocyte cell-cell adhesion 26/689 304/18670 6.541e-05 0.01956 0.01815 EGR3/NFKBIZ/ICAM1/IRF1/SIRPB1/PRDX2/LAX1/RIPK2/ARG2/NCK2/KLF4/PELI1/HES1/CEACAM1/PDCD1LG2/LEP/CD83/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/CCL28/BTN2A2 26 BP GO:0032727 positive regulation of interferon-alpha production 6/689 22/18670 0.0001111 0.03128 0.02902 STAT1/IFIH1/DDX58/RIPK2/TBK1/TLR9 6 BP GO:0001819 positive regulation of cytokine production 34/689 464/18670 0.0001213 0.03225 0.02992 PTGS2/STAT1/OSM/PDE4B/APP/IRF1/GBP5/EGR1/IFIH1/DDX58/RIOK3/RIPK2/CLU/PANX1/LRRFIP1/C5/GPATCH3/TBK1/PELI1/SPON2/THBS1/TLR9/ROCK2/C1QTNF4/HRAS/CLEC7A/LEP/AGPAT1/CD83/POLR3G/AIF1/IL15/DDX60/ZNF580 34 BP GO:0007159 leukocyte cell-cell adhesion 27/689 337/18670 0.000143 0.03602 0.03342 EGR3/NFKBIZ/ICAM1/IRF1/SIRPB1/PRDX2/LAX1/RIPK2/ARG2/NCK2/KLF4/PELI1/HES1/CEACAM1/PDCD1LG2/LEP/SELP/CD83/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/CCL28/BTN2A2 27 BP GO:0007292 female gamete generation 15/689 136/18670 0.0001521 0.03633 0.03371 PTGS2/PDE3A/ADAMTS1/H3-3B/GDF9/DMC1/REC8/LEP/NRIP1/MASTL/PDE5A/ETV6/IHH/PLK1/NOS3 15 BP GO:0042098 T cell proliferation 18/689 184/18670 0.0001643 0.03633 0.03371 IRF1/PRDX2/RIPK2/ARG2/NCK2/PELI1/HES1/PDCD1LG2/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2/ELF4 18 BP GO:0046633 alpha-beta T cell proliferation 7/689 33/18670 0.000167 0.03633 0.03371 IRF1/RIPK2/ARG2/TWSG1/ZAP70/IL15/ELF4 7 BP GO:0042832 defense response to protozoan 6/689 24/18670 0.0001882 0.03915 0.03633 GBP2/GBP7/GBP4/HRAS/CLEC7A/BATF 6 BP GO:0032642 regulation of chemokine production 11/689 82/18670 0.0002061 0.04109 0.03813 APP/EGR1/MUL1/RIPK2/ARG2/KLF4/C5/TLR9/CLEC7A/AIF1/SIGIRR 11 BP GO:0022407 regulation of cell-cell adhesion 30/689 403/18670 0.0002286 0.04253 0.03946 EGR3/NFKBIZ/ICAM1/IRF1/GCNT2/SIRPB1/PLG/PRDX2/LAX1/RIPK2/ARG2/NCK2/KLF4/PTK2/PELI1/HES1/CEACAM1/PDCD1LG2/LEP/CD83/SPINT2/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/CCL28/BTN2A2 30 BP GO:0032479 regulation of type I interferon production 14/689 126/18670 0.0002314 0.04253 0.03946 STAT1/TRAF3/IRF1/TNFAIP3/IFIH1/DDX58/RIOK3/RIPK2/LRRFIP1/GPATCH3/TBK1/TLR9/POLR3G/TRIM38 14 BP GO:0001562 response to protozoan 6/689 25/18670 0.00024 0.04253 0.03946 GBP2/GBP7/GBP4/HRAS/CLEC7A/BATF 6 BP GO:0090257 regulation of muscle system process 22/689 259/18670 0.0002567 0.04387 0.04071 PTGS2/TPM1/PDE4B/ADRA1B/CTTN/KLF4/PTK2/ATP2B4/CCN2/ROCK2/LMCD1/SPX/BMP10/MYL9/MTPN/GUCY1A1/PDE5A/AIF1/BIN1/EHD3/NOS3/DDX39B 22 BP GO:0032606 type I interferon production 14/689 128/18670 0.0002729 0.04503 0.04178 STAT1/TRAF3/IRF1/TNFAIP3/IFIH1/DDX58/RIOK3/RIPK2/LRRFIP1/GPATCH3/TBK1/TLR9/POLR3G/TRIM38 14 BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 14/689 129/18670 0.000296 0.0472 0.0438 IRF1/PRDX2/LAX1/ARG2/KLF4/PELI1/CEACAM1/PDCD1LG2/PDE5A/TWSG1/IHH/LOXL3/CCL28/BTN2A2 14 BP GO:0032760 positive regulation of tumor necrosis factor production 11/689 86/18670 0.0003152 0.04833 0.04484 APP/IFIH1/DDX58/RIPK2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 11 BP GO:0010749 regulation of nitric oxide mediated signal transduction 4/689 10/18670 0.0003232 0.04833 0.04484 ATP2B4/THBS1/GUCY1A1/PDE5A 4 BP GO:0050688 regulation of defense response to virus 10/689 73/18670 0.0003342 0.04846 0.04496 STAT1/TRAF3/TNFAIP3/MUL1/DDX58/RIOK3/GPATCH3/TRIM38/IL15/DDX60 10 BP GO:0002221 pattern recognition receptor signaling pathway 18/689 197/18670 0.0003818 0.05275 0.04895 TRAF3/IRF1/TNFAIP3/IFIH1/CTSK/DDX58/RIOK3/RIPK2/WDFY1/GPATCH3/TBK1/PELI1/TLR9/CLEC7A/NR1D1/TAB1/PRKCE/DDX60 18 BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 11/689 88/18670 0.0003859 0.05275 0.04895 APP/IFIH1/DDX58/RIPK2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 11 BP GO:0022408 negative regulation of cell-cell adhesion 17/689 181/18670 0.0003993 0.05291 0.04909 IRF1/PLG/PRDX2/LAX1/ARG2/KLF4/PTK2/PELI1/CEACAM1/PDCD1LG2/SPINT2/PDE5A/TWSG1/IHH/LOXL3/CCL28/BTN2A2 17 BP GO:0032602 chemokine production 11/689 89/18670 0.0004259 0.05291 0.04909 APP/EGR1/MUL1/RIPK2/ARG2/KLF4/C5/TLR9/CLEC7A/AIF1/SIGIRR 11 BP GO:0031331 positive regulation of cellular catabolic process 27/689 361/18670 0.0004297 0.05291 0.04909 UVRAG/BTG2/EGF/NUB1/APP/PLK3/NPRL2/TNFAIP3/ZFP36/MUL1/RIPK2/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/TBK1/PIM2/ROCK2/ZC3HAV1/AGO2/RNF19B/PABPC1/CALCOCO2/PLK1/TRIB1/MOV10 27 BP GO:0034341 response to interferon-gamma 18/689 199/18670 0.0004312 0.05291 0.04909 GBP2/GCH1/GBP1/GBP7/STAT1/NUB1/ICAM1/SOCS3/IRF1/GBP5/TRIM26/PARP14/GBP4/CCL7/TRIM68/AIF1/CALCOCO2/TRIM38 18 BP GO:0032647 regulation of interferon-alpha production 6/689 28/18670 0.0004645 0.05557 0.05156 STAT1/IFIH1/DDX58/RIPK2/TBK1/TLR9 6 BP GO:0019371 cyclooxygenase pathway 4/689 11/18670 0.0004931 0.05755 0.0534 PTGS2/PTGDS/AKR1C3/PTGS1 4 BP GO:0032481 positive regulation of type I interferon production 10/689 77/18670 0.0005171 0.05883 0.05459 STAT1/IRF1/IFIH1/DDX58/RIOK3/RIPK2/LRRFIP1/TBK1/TLR9/POLR3G 10 BP GO:0042136 neurotransmitter biosynthetic process 12/689 106/18670 0.0005356 0.05883 0.05459 PTGS2/GCH1/ICAM1/PKD2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 12 BP GO:0007263 nitric oxide mediated signal transduction 6/689 29/18670 0.0005676 0.05883 0.05459 GUCY1B1/ATP2B4/THBS1/GUCY1A1/PDE5A/NOS3 6 BP GO:0003012 muscle system process 32/689 465/18670 0.0005718 0.05883 0.05459 PTGS2/TPM1/TMOD2/PDE4B/MYOM1/ADRA1B/CTTN/ARG2/KLF4/CALD1/PTK2/ATP2B4/MYLK/CCN2/ROCK2/LMCD1/SPX/BMP10/MYL9/LEP/ITGB5/PDLIM5/MTPN/GUCY1A1/PDE5A/AIF1/BIN1/MYOF/EHD3/NOS3/IL15/DDX39B 32 BP GO:1903409 reactive oxygen species biosynthetic process 13/689 122/18670 0.0005744 0.05883 0.05459 PTGS2/GCH1/ICAM1/PKD2/SLC18A2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 13 BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 26/689 349/18670 0.0005779 0.05883 0.05459 FOS/PCSK6/VEPH1/GCNT2/BMP8A/EGR1/NLK/PARD3/ACVR1/RBPMS2/PTK2/GDF9/ONECUT2/RASL11B/HES1/MIR26A1/THBS1/BMP8B/BMP10/ITGB5/CAV2/MSX1/ING2/TWSG1/TAB1/TGIF2 26 BP GO:0070663 regulation of leukocyte proliferation 19/689 222/18670 0.0006017 0.05998 0.05566 IRF1/TNFAIP3/RIPK2/ARG2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 19 BP GO:0042129 regulation of T cell proliferation 15/689 156/18670 0.0006729 0.06051 0.05615 IRF1/RIPK2/ARG2/NCK2/PELI1/HES1/PDCD1LG2/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/BTN2A2 15 BP GO:0045428 regulation of nitric oxide biosynthetic process 9/689 66/18670 0.0006798 0.06051 0.05615 PTGS2/ICAM1/PKD2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1 9 BP GO:0032607 interferon-alpha production 6/689 30/18670 0.0006876 0.06051 0.05615 STAT1/IFIH1/DDX58/RIPK2/TBK1/TLR9 6 BP GO:0038003 opioid receptor signaling pathway 4/689 12/18670 0.0007181 0.06051 0.05615 OGFR/OPRD1/NPBWR2/NPBWR1 4 BP GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 4/689 12/18670 0.0007181 0.06051 0.05615 BTG2/ZFP36/AGO2/PABPC1 4 BP GO:0051090 regulation of DNA-binding transcription factor activity 30/689 432/18670 0.0007261 0.06051 0.05615 FOS/ICAM1/APP/TRAF3/PKD2/TRIM26/TNFAIP3/DDX58/PRDX2/RIPK2/CLU/LRRFIP1/KLF4/ID3/PELI1/C3orf33/OPRD1/MIR26A1/RNF31/TLR9/ROR1/SGK1/MTPN/TAB1/TRAPPC9/TRIM38/TRIB1/SIGIRR/TNFRSF4/SAV1 30 BP GO:0070661 leukocyte proliferation 23/689 298/18670 0.0007282 0.06051 0.05615 IRF1/TNFAIP3/PRDX2/RIPK2/ARG2/CLU/NCK2/TBK1/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2/ELF4 23 BP GO:0050670 regulation of lymphocyte proliferation 18/689 208/18670 0.0007287 0.06051 0.05615 IRF1/RIPK2/ARG2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 18 BP GO:0045088 regulation of innate immune response 31/689 452/18670 0.0007327 0.06051 0.05615 STAT1/TRAF3/SOCS3/IRF1/GBP5/TNFAIP3/IFIH1/MUL1/PARP14/TRAFD1/CTSK/DDX58/RIOK3/RIPK2/SERPING1/WDFY1/NCR1/GPATCH3/TBK1/PELI1/CEACAM1/TLR9/HRAS/CLEC7A/LEP/POLR3G/NR1D1/TAB1/PRKCE/SH2D1B/DDX60 31 BP GO:0007596 blood coagulation 25/689 336/18670 0.0007447 0.06051 0.05615 ITPK1/IRF1/F13A1/PLG/PRDX2/SERPING1/GP6/H3-3B/SERPINC1/CEACAM1/GP1BA/THBS1/P2RY12/GNA13/MMRN1/MPL/ITPR2/MYL9/DTNBP1/SELP/PRKCE/ITGB3/EHD3/NOS3/CLEC1B 25 BP GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 11/689 95/18670 0.0007462 0.06051 0.05615 EGF/NUB1/PLK3/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/RNF19B/PLK1/TRIB1 11 BP GO:0032944 regulation of mononuclear cell proliferation 18/689 209/18670 0.0007707 0.06146 0.05703 IRF1/RIPK2/ARG2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 18 BP GO:1903706 regulation of hemopoiesis 32/689 475/18670 0.0008177 0.06414 0.05952 EGR3/FOS/STAT1/OSM/NFKBIZ/IRF1/ZFP36/PRDX2/KLF10/RIPK2/H3-3B/FBXW7/SMAP1/HES1/CEACAM1/GP1BA/THBS1/TLR9/MPL/MYL9/CD83/ATP11C/H4C8/IHH/TRIB1/ZAP70/MOV10/LOXL3/IL15/RBFOX2/BTN2A2/N4BP2L2 32 BP GO:0030728 ovulation 5/689 21/18670 0.000839 0.06475 0.06008 PTGS2/ADAMTS1/LEP/NRIP1/NOS3 5 BP GO:0097581 lamellipodium organization 10/689 82/18670 0.0008552 0.06495 0.06027 FSCN1/CTTN/AUTS2/ABLIM3/PLEKHO1/NCK2/NCKAP1/P2RY12/VIL1/WASF3 10 BP GO:0050868 negative regulation of T cell activation 12/689 112/18670 0.0008799 0.0656 0.06087 IRF1/PRDX2/LAX1/ARG2/PELI1/CEACAM1/PDCD1LG2/PDE5A/TWSG1/IHH/LOXL3/BTN2A2 12 BP GO:0002576 platelet degranulation 13/689 128/18670 0.0009054 0.0656 0.06087 GTPBP2/EGF/APP/F13A1/PLG/VTI1B/SERPING1/CLU/THBS1/MMRN1/SELP/SYTL4/ITGB3 13 BP GO:0045429 positive regulation of nitric oxide biosynthetic process 7/689 43/18670 0.0009151 0.0656 0.06087 PTGS2/ICAM1/PKD2/CLU/KLF4/CLEC7A/AIF1 7 BP GO:0007599 hemostasis 25/689 341/18670 0.0009193 0.0656 0.06087 ITPK1/IRF1/F13A1/PLG/PRDX2/SERPING1/GP6/H3-3B/SERPINC1/CEACAM1/GP1BA/THBS1/P2RY12/GNA13/MMRN1/MPL/ITPR2/MYL9/DTNBP1/SELP/PRKCE/ITGB3/EHD3/NOS3/CLEC1B 25 BP GO:2000377 regulation of reactive oxygen species metabolic process 17/689 195/18670 0.0009323 0.0656 0.06087 PTGS2/GCH1/ICAM1/PKD2/SLC18A2/PRDX2/ARG2/CLU/AKR1C3/KLF4/ATP2B4/THBS1/ROCK2/CLEC7A/LEP/AIF1/SIRT3 17 BP GO:0050817 coagulation 25/689 342/18670 0.0009583 0.06645 0.06166 ITPK1/IRF1/F13A1/PLG/PRDX2/SERPING1/GP6/H3-3B/SERPINC1/CEACAM1/GP1BA/THBS1/P2RY12/GNA13/MMRN1/MPL/ITPR2/MYL9/DTNBP1/SELP/PRKCE/ITGB3/EHD3/NOS3/CLEC1B 25 BP GO:0010454 negative regulation of cell fate commitment 4/689 13/18670 0.001007 0.06787 0.06298 NKX6-2/GLIS1/HES1/LOXL3 4 BP GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 4/689 13/18670 0.001007 0.06787 0.06298 TNFAIP3/PRDX2/TRIB1/SIGIRR 4 BP GO:1904407 positive regulation of nitric oxide metabolic process 7/689 44/18670 0.001054 0.07005 0.065 PTGS2/ICAM1/PKD2/CLU/KLF4/CLEC7A/AIF1 7 BP GO:0042110 T cell activation 31/689 464/18670 0.00112 0.0728 0.06755 EGR3/NFKBIZ/ICAM1/IRF1/EGR1/SIRPB1/PRDX2/JMJD6/LAX1/RIPK2/ARG2/LEPR/NCK2/PELI1/HES1/CEACAM1/PDCD1LG2/CLEC7A/LEP/CD83/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/TNFRSF4/BTN2A2/ELF4/BATF 31 BP GO:0007162 negative regulation of cell adhesion 22/689 289/18670 0.001126 0.0728 0.06755 PHLDB2/DUSP1/GBP1/IRF1/GCNT2/PLG/PRDX2/LAX1/ARG2/KLF4/PTK2/PELI1/CEACAM1/PDCD1LG2/THBS1/SPINT2/PDE5A/TWSG1/IHH/LOXL3/CCL28/BTN2A2 22 BP GO:0007179 transforming growth factor beta receptor signaling pathway 17/689 199/18670 0.001167 0.07443 0.06906 FOS/VEPH1/GCNT2/NLK/PARD3/ACVR1/PTK2/GDF9/ONECUT2/RASL11B/MIR26A1/THBS1/ITGB5/CAV2/ING2/TWSG1/TAB1 17 BP GO:0030041 actin filament polymerization 16/689 182/18670 0.001192 0.07505 0.06964 TMOD2/PSTPIP2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/WASF3/RHOBTB2/AIF1/BIN1/PRKCE 16 BP GO:0046651 lymphocyte proliferation 21/689 272/18670 0.001212 0.0753 0.06988 IRF1/PRDX2/RIPK2/ARG2/NCK2/TBK1/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2/ELF4 21 BP GO:1903426 regulation of reactive oxygen species biosynthetic process 11/689 101/18670 0.001245 0.07609 0.0706 PTGS2/ICAM1/PKD2/SLC18A2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1 11 BP GO:0014074 response to purine-containing compound 14/689 149/18670 0.001256 0.07609 0.0706 PTGS2/DUSP1/PDE3A/FOS/XRN1/STAT1/APP/JUNB/PKD2/JUND/PANX1/FOSB/P2RY12/ITPR2 14 BP GO:0071559 response to transforming growth factor beta 20/689 255/18670 0.001298 0.07762 0.07202 PDE3A/FOS/VEPH1/GCNT2/NLK/PARD3/ACVR1/PTK2/GDF9/ONECUT2/RASL11B/MIR26A1/PDCD5/THBS1/ROCK2/ITGB5/CAV2/ING2/TWSG1/TAB1 20 BP GO:0032943 mononuclear cell proliferation 21/689 274/18670 0.001328 0.07843 0.07278 IRF1/PRDX2/RIPK2/ARG2/NCK2/TBK1/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/PDE5A/AIF1/TWSG1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2/ELF4 21 BP GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 4/689 14/18670 0.001369 0.07975 0.074 BTG2/ZFP36/AGO2/PABPC1 4 BP GO:0046683 response to organophosphorus 13/689 134/18670 0.001383 0.07975 0.074 PTGS2/DUSP1/PDE3A/FOS/STAT1/APP/JUNB/PKD2/JUND/PANX1/FOSB/P2RY12/ITPR2 13 BP GO:1903708 positive regulation of hemopoiesis 16/689 185/18670 0.001415 0.0806 0.07479 EGR3/FOS/STAT1/NFKBIZ/KLF10/RIPK2/SMAP1/MPL/CD83/ATP11C/IHH/TRIB1/ZAP70/IL15/BTN2A2/N4BP2L2 16 BP GO:0050863 regulation of T cell activation 23/689 314/18670 0.001465 0.08152 0.07564 EGR3/NFKBIZ/IRF1/SIRPB1/PRDX2/LAX1/RIPK2/ARG2/NCK2/PELI1/HES1/CEACAM1/PDCD1LG2/LEP/CD83/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/BTN2A2 23 BP GO:0048511 rhythmic process 22/689 295/18670 0.001465 0.08152 0.07564 EGR3/EGR2/HEBP1/PTGDS/ADAMTS1/EGR1/JUND/NFIL3/ATOH7/KLF10/TEF/GDF9/FBXW7/ID3/ROCK2/LEP/NRIP1/PER3/NR1D1/PROKR2/NOS3/SETX 22 BP GO:0034142 toll-like receptor 4 signaling pathway 6/689 35/18670 0.001607 0.0884 0.08203 TNFAIP3/RIPK2/WDFY1/PELI1/NR1D1/PRKCE 6 BP GO:0043901 negative regulation of multi-organism process 15/689 171/18670 0.001712 0.09298 0.08628 STAT1/TRIM26/TNFAIP3/ZFP36/MUL1/PRDX2/RIOK3/ARG2/GPATCH3/FAM111A/ZC3HAV1/ISG20/TRIM38/TRIB1/SIGIRR 15 BP GO:0090303 positive regulation of wound healing 8/689 61/18670 0.001729 0.09298 0.08628 PLG/PRDX2/MYLK/THBS1/HRAS/CLEC7A/SELP/PRKCE 8 BP GO:0061014 positive regulation of mRNA catabolic process 7/689 48/18670 0.001783 0.09482 0.08798 BTG2/ZFP36/ROCK2/ZC3HAV1/AGO2/PABPC1/MOV10 7 BP GO:0043500 muscle adaptation 12/689 122/18670 0.001854 0.09685 0.08986 KLF4/PTK2/ATP2B4/ROCK2/LMCD1/BMP10/MTPN/PDE5A/AIF1/NOS3/IL15/DDX39B 12 BP GO:0007623 circadian rhythm 17/689 208/18670 0.001882 0.09685 0.08986 EGR3/HEBP1/PTGDS/EGR1/JUND/NFIL3/ATOH7/KLF10/FBXW7/ID3/ROCK2/LEP/NRIP1/PER3/NR1D1/PROKR2/SETX 17 BP GO:0060333 interferon-gamma-mediated signaling pathway 10/689 91/18670 0.001911 0.09685 0.08986 GBP2/GBP1/STAT1/ICAM1/SOCS3/IRF1/TRIM26/PARP14/TRIM68/TRIM38 10 BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 8/689 62/18670 0.001923 0.09685 0.08986 TNFAIP3/IFIH1/DDX58/RIOK3/RIPK2/GPATCH3/TAB1/DDX60 8 BP GO:0032623 interleukin-2 production 8/689 62/18670 0.001923 0.09685 0.08986 GBP1/PDE4B/TNFAIP3/ZFP36/RIPK2/CLEC7A/CD83/CD247 8 BP GO:0043502 regulation of muscle adaptation 11/689 107/18670 0.00199 0.0992 0.09205 KLF4/PTK2/ATP2B4/ROCK2/LMCD1/BMP10/MTPN/PDE5A/AIF1/NOS3/DDX39B 11 BP GO:0002695 negative regulation of leukocyte activation 15/689 175/18670 0.002148 0.105 0.09741 IRF1/TNFAIP3/PRDX2/LAX1/ARG2/PELI1/CEACAM1/PDCD1LG2/CNR2/NR1D1/PDE5A/TWSG1/IHH/LOXL3/BTN2A2 15 BP GO:0002237 response to molecule of bacterial origin 24/689 343/18670 0.002151 0.105 0.09741 PTGS2/FOS/GCH1/CXCL8/PDE4B/ICAM1/JUNB/JUND/TNFAIP3/ZFP36/PRDX2/RIPK2/PELI1/PDCD1LG2/SPON2/TLR9/CNR2/SELP/NR1D1/GNG12/PRKCE/NOS3/TRIB1/SIGIRR 24 BP GO:0009896 positive regulation of catabolic process 28/689 423/18670 0.002178 0.105 0.09741 UVRAG/BTG2/EGF/NUB1/APP/PLK3/NPRL2/TNFAIP3/ZFP36/MUL1/RIPK2/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/TBK1/PIM2/ROCK2/ZC3HAV1/AGO2/RNF19B/PABPC1/CALCOCO2/PRKCE/PLK1/TRIB1/MOV10 28 BP GO:1903829 positive regulation of cellular protein localization 23/689 324/18670 0.002194 0.105 0.09741 PTGS2/PMAIP1/RAMP3/EGF/VAMP2/PLK3/YWHAH/MAP1A/LEPROT/ABLIM3/FBXW7/RNF31/PDCD5/ROCK2/HRAS/CNPY4/LEP/VIL1/STOM/CD247/PRKCE/RAB11A/PLK1 23 BP GO:0071560 cellular response to transforming growth factor beta stimulus 19/689 249/18670 0.002317 0.1098 0.1019 PDE3A/FOS/VEPH1/GCNT2/NLK/PARD3/ACVR1/PTK2/GDF9/ONECUT2/RASL11B/MIR26A1/PDCD5/THBS1/ITGB5/CAV2/ING2/TWSG1/TAB1 19 BP GO:0043254 regulation of protein complex assembly 30/689 467/18670 0.002424 0.1124 0.1043 PMAIP1/TMOD2/RNF4/ICAM1/GBP5/NAPA/FSCN1/RHOBTB1/ARHGAP18/RIOK3/CTTN/MPP7/CLU/NCK2/H3-3B/PREB/OPRD1/RASIP1/NCKAP1/P2RY12/ACTR3B/CLEC7A/SELP/VIL1/MTPN/RHOBTB2/BIN1/PRKCE/SETX/THRA 30 BP GO:0018107 peptidyl-threonine phosphorylation 12/689 126/18670 0.002435 0.1124 0.1043 EGF/APP/PRKAG2/NLK/PARD3/ACVR1/RIPK2/TBK1/ROCK2/HASPIN/TTBK2/PLK1 12 BP GO:0032680 regulation of tumor necrosis factor production 14/689 160/18670 0.002461 0.1124 0.1043 APP/TNFAIP3/IFIH1/ZFP36/DDX58/RIPK2/ARG2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 14 BP GO:0030193 regulation of blood coagulation 9/689 79/18670 0.002475 0.1124 0.1043 PLG/PRDX2/SERPING1/SERPINC1/CEACAM1/GP1BA/THBS1/SELP/NOS3 9 BP GO:1903523 negative regulation of blood circulation 6/689 38/18670 0.00249 0.1124 0.1043 MIR26A1/SPX/RNLS/LEP/PDE5A/BIN1 6 BP GO:1900046 regulation of hemostasis 9/689 80/18670 0.002699 0.1207 0.112 PLG/PRDX2/SERPING1/SERPINC1/CEACAM1/GP1BA/THBS1/SELP/NOS3 9 BP GO:0032496 response to lipopolysaccharide 23/689 330/18670 0.002765 0.1217 0.1129 PTGS2/FOS/GCH1/CXCL8/PDE4B/ICAM1/JUNB/JUND/TNFAIP3/ZFP36/PRDX2/RIPK2/PELI1/PDCD1LG2/SPON2/CNR2/SELP/NR1D1/GNG12/PRKCE/NOS3/TRIB1/SIGIRR 23 BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 5/689 27/18670 0.002772 0.1217 0.1129 IFIH1/DDX58/RIOK3/GPATCH3/DDX60 5 BP GO:0071346 cellular response to interferon-gamma 15/689 180/18670 0.00282 0.1227 0.1138 GBP2/GBP1/GBP7/STAT1/ICAM1/SOCS3/IRF1/GBP5/TRIM26/PARP14/GBP4/CCL7/TRIM68/AIF1/TRIM38 15 BP GO:0032640 tumor necrosis factor production 14/689 163/18670 0.00292 0.1247 0.1157 APP/TNFAIP3/IFIH1/ZFP36/DDX58/RIPK2/ARG2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 14 BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 14/689 163/18670 0.00292 0.1247 0.1157 APP/TNFAIP3/IFIH1/ZFP36/DDX58/RIPK2/ARG2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 14 BP GO:0051250 negative regulation of lymphocyte activation 13/689 146/18670 0.002973 0.1248 0.1158 IRF1/TNFAIP3/PRDX2/LAX1/ARG2/PELI1/CEACAM1/PDCD1LG2/PDE5A/TWSG1/IHH/LOXL3/BTN2A2 13 BP GO:0050866 negative regulation of cell activation 16/689 199/18670 0.002973 0.1248 0.1158 IRF1/TNFAIP3/PRDX2/LAX1/ARG2/PELI1/CEACAM1/PDCD1LG2/CNR2/NR1D1/PDE5A/TWSG1/IHH/NOS3/LOXL3/BTN2A2 16 BP GO:0050671 positive regulation of lymphocyte proliferation 12/689 130/18670 0.003156 0.1313 0.1218 RIPK2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/AIF1/ZAP70/IL15/TNFRSF4 12 BP GO:0043331 response to dsRNA 7/689 53/18670 0.003186 0.1314 0.1219 PMAIP1/IFIH1/MUL1/DDX58/RIOK3/RIPK2/PELI1 7 BP GO:0042035 regulation of cytokine biosynthetic process 11/689 114/18670 0.003281 0.1342 0.1245 APP/IRF1/EGR1/ZFP36/KLF4/TBK1/MIR26A1/THBS1/TLR9/CLEC7A/SIGIRR 11 BP GO:0032946 positive regulation of mononuclear cell proliferation 12/689 131/18670 0.003361 0.1353 0.1255 RIPK2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/AIF1/ZAP70/IL15/TNFRSF4 12 BP GO:0001818 negative regulation of cytokine production 21/689 296/18670 0.003365 0.1353 0.1255 GBP1/TNFAIP3/IFIH1/ZFP36/MUL1/DDX58/ARG2/KLF4/GPATCH3/TBK1/CEACAM1/MIR26A1/PDCD1LG2/THBS1/TLR9/CD83/TWSG1/SIGIRR/TNFRSF4/BTN2A2/LAPTM4B 21 BP GO:1903900 regulation of viral life cycle 13/689 149/18670 0.003545 0.1398 0.1297 CXCL8/TRIM26/ZNF502/RAD23A/LAMP3/STAU1/FAM111A/ZC3HAV1/CAV2/ISG20/PABPC1/STOM/TRIM38 13 BP GO:0032663 regulation of interleukin-2 production 7/689 54/18670 0.003546 0.1398 0.1297 GBP1/PDE4B/TNFAIP3/ZFP36/RIPK2/CLEC7A/CD83 7 BP GO:0030838 positive regulation of actin filament polymerization 10/689 99/18670 0.003565 0.1398 0.1297 ICAM1/RHOBTB1/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/RHOBTB2/BIN1/PRKCE 10 BP GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/689 18/18670 0.003721 0.1418 0.1316 BTG2/ZFP36/AGO2/PABPC1 4 BP GO:0050818 regulation of coagulation 9/689 84/18670 0.003764 0.1418 0.1316 PLG/PRDX2/SERPING1/SERPINC1/CEACAM1/GP1BA/THBS1/SELP/NOS3 9 BP GO:1902905 positive regulation of supramolecular fiber organization 16/689 204/18670 0.003795 0.1418 0.1316 TPM1/ICAM1/APP/RHOBTB1/CTTN/CLU/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/BMP10/VIL1/RHOBTB2/BIN1/PRKCE 16 BP GO:0090174 organelle membrane fusion 10/689 100/18670 0.003834 0.1418 0.1316 TAP2/UVRAG/SAMD9L/VTI1B/ANKFY1/STX17/CAV2/VCPIP1/TAP1/SAMD9 10 BP GO:0071706 tumor necrosis factor superfamily cytokine production 14/689 168/18670 0.003837 0.1418 0.1316 APP/TNFAIP3/IFIH1/ZFP36/DDX58/RIPK2/ARG2/CLU/SPON2/THBS1/TLR9/C1QTNF4/CLEC7A/LEP 14 BP GO:0010800 positive regulation of peptidyl-threonine phosphorylation 5/689 29/18670 0.003838 0.1418 0.1316 EGF/APP/PRKAG2/RIPK2/PLK1 5 BP GO:0045822 negative regulation of heart contraction 5/689 29/18670 0.003838 0.1418 0.1316 MIR26A1/SPX/RNLS/PDE5A/BIN1 5 BP GO:0030522 intracellular receptor signaling pathway 20/689 280/18670 0.003852 0.1418 0.1316 NR4A2/RNF4/TNFAIP3/IFIH1/YWHAH/DDX58/CYP7B1/RIOK3/RIPK2/AKR1C3/GPATCH3/GPAM/TRIM68/LEP/NRIP1/NR1D1/TAB1/THRA/RBFOX2/DDX60 20 BP GO:0018210 peptidyl-threonine modification 12/689 134/18670 0.004041 0.1476 0.137 EGF/APP/PRKAG2/NLK/PARD3/ACVR1/RIPK2/TBK1/ROCK2/HASPIN/TTBK2/PLK1 12 BP GO:0010613 positive regulation of cardiac muscle hypertrophy 6/689 42/18670 0.004177 0.1514 0.1405 PTK2/ROCK2/BMP10/MTPN/PDE5A/DDX39B 6 BP GO:0043902 positive regulation of multi-organism process 15/689 188/18670 0.004248 0.1528 0.1418 PDE3A/GTF2F2/ZNF502/RIPK2/RAD23A/TBK1/STAU1/CLEC7A/CAV2/AGO2/PDE5A/PABPC1/STOM/TRIM38/DDX60 15 BP GO:2000379 positive regulation of reactive oxygen species metabolic process 10/689 102/18670 0.004419 0.1572 0.1459 PTGS2/ICAM1/PKD2/CLU/AKR1C3/KLF4/THBS1/CLEC7A/LEP/AIF1 10 BP GO:0030168 platelet activation 13/689 153/18670 0.004443 0.1572 0.1459 GP6/CEACAM1/GP1BA/P2RY12/GNA13/MPL/ITPR2/MYL9/SELP/PRKCE/ITGB3/NOS3/CLEC1B 13 BP GO:0046640 regulation of alpha-beta T cell proliferation 5/689 30/18670 0.004468 0.1572 0.1459 IRF1/RIPK2/ARG2/TWSG1/ZAP70 5 BP GO:0072593 reactive oxygen species metabolic process 20/689 284/18670 0.004509 0.1575 0.1461 PTGS2/PMAIP1/GCH1/ICAM1/PKD2/SLC18A2/PRDX2/ARG2/CLU/AKR1C3/KLF4/ATP2B4/THBS1/CCN2/ROCK2/CLEC7A/LEP/AIF1/SIRT3/NOS3 20 BP GO:0050792 regulation of viral process 16/689 208/18670 0.00458 0.1588 0.1474 STAT1/CXCL8/GTF2F2/TRIM26/ZFP36/ZNF502/RAD23A/LAMP3/STAU1/FAM111A/ZC3HAV1/CAV2/ISG20/PABPC1/STOM/TRIM38 16 BP GO:0060759 regulation of response to cytokine stimulus 15/689 190/18670 0.004684 0.1597 0.1482 STAT1/SOCS3/TNFAIP3/IFIH1/MUL1/PARP14/DDX58/RIPK2/KLF4/TBK1/MIR26A1/RNF31/C1QTNF4/AGPAT1/SIGIRR 15 BP GO:0061025 membrane fusion 13/689 154/18670 0.004694 0.1597 0.1482 TAP2/UVRAG/VAMP2/NAPA/SAMD9L/VTI1B/ANKFY1/RABIF/STX17/CAV2/VCPIP1/TAP1/SAMD9 13 BP GO:0014742 positive regulation of muscle hypertrophy 6/689 43/18670 0.004706 0.1597 0.1482 PTK2/ROCK2/BMP10/MTPN/PDE5A/DDX39B 6 BP GO:0008154 actin polymerization or depolymerization 16/689 209/18670 0.004796 0.1598 0.1483 TMOD2/PSTPIP2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/WASF3/RHOBTB2/AIF1/BIN1/PRKCE 16 BP GO:0060760 positive regulation of response to cytokine stimulus 7/689 57/18670 0.004815 0.1598 0.1483 IFIH1/PARP14/DDX58/RIPK2/TBK1/C1QTNF4/AGPAT1 7 BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 7/689 57/18670 0.004815 0.1598 0.1483 PTGS2/ICAM1/PKD2/CLU/KLF4/CLEC7A/AIF1 7 BP GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 11/689 120/18670 0.004857 0.1598 0.1483 EGF/NUB1/PLK3/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/RNF19B/PLK1/TRIB1 11 BP GO:0001787 natural killer cell proliferation 3/689 10/18670 0.004944 0.1598 0.1483 LEP/IL15/ELF4 3 BP GO:0034058 endosomal vesicle fusion 3/689 10/18670 0.004944 0.1598 0.1483 SAMD9L/ANKFY1/SAMD9 3 BP GO:0039530 MDA-5 signaling pathway 3/689 10/18670 0.004944 0.1598 0.1483 IFIH1/RIOK3/DDX60 3 BP GO:0003018 vascular process in circulatory system 14/689 173/18670 0.004976 0.1598 0.1483 PTGS2/PDE3A/GCH1/ICAM1/ADRA1B/FGFBP3/CEACAM1/ROCK2/UTS2B/ADRB3/LEP/GUCY1A1/C2CD4A/NOS3 14 BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 10/689 104/18670 0.005073 0.1612 0.1496 BMP8A/ACVR1/GDF9/HES1/THBS1/BMP8B/BMP10/MSX1/ING2/TWSG1 10 BP GO:0046631 alpha-beta T cell activation 12/689 138/18670 0.005115 0.1612 0.1496 NFKBIZ/IRF1/RIPK2/ARG2/CD83/TWSG1/IHH/ZAP70/LOXL3/IL15/ELF4/BATF 12 BP GO:0010506 regulation of autophagy 22/689 327/18670 0.005122 0.1612 0.1496 ATP6V0A2/UVRAG/PLK3/NPRL2/PRKAG2/ATP6V0E2/MUL1/CTTN/RIPK2/LEPR/LAMTOR1/PTK2/FBXW7/TBK1/LAMP3/RASIP1/PIM2/MCL1/RUBCN/LEP/CALCOCO2/ATP6V1G2 22 BP GO:0031334 positive regulation of protein complex assembly 19/689 268/18670 0.005171 0.1617 0.1501 PMAIP1/ICAM1/GBP5/FSCN1/RHOBTB1/CTTN/MPP7/CLU/NCK2/RASIP1/NCKAP1/P2RY12/ACTR3B/CLEC7A/VIL1/RHOBTB2/BIN1/PRKCE/SETX 19 BP GO:0031663 lipopolysaccharide-mediated signaling pathway 7/689 58/18670 0.005306 0.1617 0.1501 TNFAIP3/PRDX2/RIPK2/PRKCE/NOS3/TRIB1/SIGIRR 7 BP GO:0032722 positive regulation of chemokine production 7/689 58/18670 0.005306 0.1617 0.1501 APP/EGR1/RIPK2/C5/TLR9/CLEC7A/AIF1 7 BP GO:0035904 aorta development 7/689 58/18670 0.005306 0.1617 0.1501 PKD2/HES1/SNX17/MYLK/LEP/TAB1/DCTN5 7 BP GO:1903749 positive regulation of establishment of protein localization to mitochondrion 7/689 58/18670 0.005306 0.1617 0.1501 PMAIP1/YWHAH/LEPROT/ABLIM3/FBXW7/RNF31/PDCD5 7 BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 19/689 269/18670 0.005378 0.1629 0.1511 STAT1/TNFAIP3/MUL1/RIOK3/RIPK2/TLE1/TBK1/PELI1/RNF31/FAIM/PIM2/TLR9/ROCK2/ROR1/NR1D1/TAB1/PRKCE/TRIM38/PLEKHG5 19 BP GO:0070665 positive regulation of leukocyte proliferation 12/689 139/18670 0.005416 0.163 0.1512 RIPK2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/LEP/AIF1/ZAP70/IL15/TNFRSF4 12 BP GO:0034143 regulation of toll-like receptor 4 signaling pathway 4/689 20/18670 0.005557 0.1631 0.1514 TNFAIP3/WDFY1/PELI1/NR1D1 4 BP GO:0050860 negative regulation of T cell receptor signaling pathway 4/689 20/18670 0.005557 0.1631 0.1514 GBP1/PHPT1/CEACAM1/BTN2A2 4 BP GO:0070262 peptidyl-serine dephosphorylation 4/689 20/18670 0.005557 0.1631 0.1514 PPP1R15A/DUSP1/PPTC7/PPP2R2D 4 BP GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/689 20/18670 0.005557 0.1631 0.1514 BTG2/ZFP36/AGO2/PABPC1 4 BP GO:1903364 positive regulation of cellular protein catabolic process 12/689 140/18670 0.005731 0.1665 0.1545 EGF/NUB1/PLK3/TNFAIP3/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/RNF19B/PLK1/TRIB1 12 BP GO:0003300 cardiac muscle hypertrophy 10/689 106/18670 0.0058 0.1665 0.1545 PTK2/ATP2B4/ROCK2/LMCD1/BMP10/LEP/PDLIM5/MTPN/PDE5A/DDX39B 10 BP GO:1903036 positive regulation of response to wounding 8/689 74/18670 0.005832 0.1665 0.1545 PLG/PRDX2/MYLK/THBS1/HRAS/CLEC7A/SELP/PRKCE 8 BP GO:0042130 negative regulation of T cell proliferation 7/689 59/18670 0.005833 0.1665 0.1545 ARG2/PELI1/PDCD1LG2/PDE5A/TWSG1/IHH/BTN2A2 7 BP GO:0042089 cytokine biosynthetic process 11/689 123/18670 0.005844 0.1665 0.1545 APP/IRF1/EGR1/ZFP36/KLF4/TBK1/MIR26A1/THBS1/TLR9/CLEC7A/SIGIRR 11 BP GO:1903955 positive regulation of protein targeting to mitochondrion 5/689 32/18670 0.005942 0.1674 0.1553 LEPROT/ABLIM3/FBXW7/RNF31/PDCD5 5 BP GO:1903035 negative regulation of response to wounding 9/689 90/18670 0.005946 0.1674 0.1553 PHLDB2/PLG/SERPING1/RTN4RL1/CEACAM1/GP1BA/THBS1/RTN4R/NOS3 9 BP GO:1902903 regulation of supramolecular fiber organization 23/689 352/18670 0.006043 0.1691 0.1569 PHLDB2/TPM1/TMOD2/ICAM1/APP/RHOBTB1/ARHGAP18/CTTN/MAP1A/CLU/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/BMP10/TAOK1/VIL1/MTPN/RHOBTB2/BIN1/PRKCE/TTBK2 23 BP GO:1904951 positive regulation of establishment of protein localization 28/689 456/18670 0.006127 0.1705 0.1582 PTGS2/PMAIP1/OSM/VAMP2/PLK3/MYOM1/IFIH1/YWHAH/DDX58/GLUL/RIPK2/LEPROT/ABLIM3/PANX1/PHPT1/C5/FBXW7/RNF31/PDCD5/C1QTNF4/HRAS/LEP/SYTL4/AIF1/SIRT3/STOM/PRKCE/TNFRSF4 28 BP GO:0042107 cytokine metabolic process 11/689 124/18670 0.006206 0.1707 0.1584 APP/IRF1/EGR1/ZFP36/KLF4/TBK1/MIR26A1/THBS1/TLR9/CLEC7A/SIGIRR 11 BP GO:0048284 organelle fusion 11/689 124/18670 0.006206 0.1707 0.1584 TAP2/UVRAG/SAMD9L/MUL1/VTI1B/ANKFY1/STX17/CAV2/VCPIP1/TAP1/SAMD9 11 BP GO:0010611 regulation of cardiac muscle hypertrophy 8/689 75/18670 0.006323 0.1729 0.1604 PTK2/ATP2B4/ROCK2/LMCD1/BMP10/MTPN/PDE5A/DDX39B 8 BP GO:1901096 regulation of autophagosome maturation 3/689 11/18670 0.006613 0.1798 0.1668 UVRAG/RUBCN/CALCOCO2 3 BP GO:0032682 negative regulation of chemokine production 4/689 21/18670 0.006668 0.1802 0.1673 MUL1/ARG2/KLF4/SIGIRR 4 BP GO:0071985 multivesicular body sorting pathway 5/689 33/18670 0.006795 0.1827 0.1695 UVRAG/LEPROT/RUBCN/SYTL4/LAPTM4B 5 BP GO:0051222 positive regulation of protein transport 26/689 418/18670 0.006879 0.1839 0.1706 PTGS2/OSM/VAMP2/PLK3/MYOM1/IFIH1/DDX58/GLUL/RIPK2/LEPROT/ABLIM3/PANX1/PHPT1/C5/FBXW7/RNF31/PDCD5/C1QTNF4/HRAS/LEP/SYTL4/AIF1/SIRT3/STOM/PRKCE/TNFRSF4 26 BP GO:1903902 positive regulation of viral life cycle 7/689 61/18670 0.007004 0.1857 0.1723 ZNF502/RAD23A/STAU1/CAV2/PABPC1/STOM/TRIM38 7 BP GO:0014897 striated muscle hypertrophy 10/689 109/18670 0.00704 0.1857 0.1723 PTK2/ATP2B4/ROCK2/LMCD1/BMP10/LEP/PDLIM5/MTPN/PDE5A/DDX39B 10 BP GO:0007050 cell cycle arrest 17/689 237/18670 0.007066 0.1857 0.1723 PPP1R15A/DUSP1/BTG2/CXCL8/NBN/IRF1/PLK3/PLAGL1/PKD2/PRKAG2/CDC14B/LAMTOR1/GADD45GIP1/HMGN5/THBS1/HRAS/BIN1 17 BP GO:0030833 regulation of actin filament polymerization 13/689 162/18670 0.007137 0.1857 0.1723 TMOD2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 13 BP GO:1902107 positive regulation of leukocyte differentiation 12/689 144/18670 0.00714 0.1857 0.1723 EGR3/FOS/NFKBIZ/KLF10/RIPK2/CD83/ATP11C/IHH/TRIB1/ZAP70/IL15/BTN2A2 12 BP GO:1903522 regulation of blood circulation 20/689 297/18670 0.007317 0.1871 0.1736 PTGS2/TPM1/GCH1/PDE4B/ICAM1/ADRA1B/MIR26A1/ATP2B4/CCN2/SPX/ITPR2/BMP10/RNLS/LEP/TMEM65/PDE5A/BIN1/EHD3/NOS3/THRA 20 BP GO:0010799 regulation of peptidyl-threonine phosphorylation 6/689 47/18670 0.007323 0.1871 0.1736 EGF/APP/PRKAG2/PARD3/RIPK2/PLK1 6 BP GO:1901659 glycosyl compound biosynthetic process 6/689 47/18670 0.007323 0.1871 0.1736 NME4/PRTFDC1/LCMT2/APRT/NME7/UCK2 6 BP GO:0046634 regulation of alpha-beta T cell activation 9/689 93/18670 0.00735 0.1871 0.1736 NFKBIZ/IRF1/RIPK2/ARG2/CD83/TWSG1/IHH/ZAP70/LOXL3 9 BP GO:0051249 regulation of lymphocyte activation 29/689 485/18670 0.007626 0.1919 0.178 EGR3/NFKBIZ/IRF1/SIRPB1/TNFAIP3/PRDX2/LAX1/RIPK2/ARG2/NCK2/PELI1/HES1/CEACAM1/PDCD1LG2/TLR9/MPL/CLEC7A/LEP/CD83/ATP11C/PDE5A/AIF1/TWSG1/IHH/ZAP70/LOXL3/IL15/TNFRSF4/BTN2A2 29 BP GO:0006220 pyrimidine nucleotide metabolic process 7/689 62/18670 0.007651 0.1919 0.178 OGG1/DCTPP1/NME4/GPAM/AGPAT1/NME7/UCK2 7 BP GO:0031348 negative regulation of defense response 17/689 239/18670 0.007659 0.1919 0.178 SOCS3/METRNL/TNFAIP3/MUL1/PARP14/MVK/TRAFD1/RIOK3/ARG2/SERPING1/KLF4/GPATCH3/CEACAM1/MIR26A1/CNR2/NR1D1/TRIM38 17 BP GO:0006906 vesicle fusion 9/689 94/18670 0.007871 0.193 0.1791 TAP2/UVRAG/SAMD9L/VTI1B/ANKFY1/STX17/CAV2/TAP1/SAMD9 9 BP GO:0045621 positive regulation of lymphocyte differentiation 9/689 94/18670 0.007871 0.193 0.1791 EGR3/NFKBIZ/RIPK2/CD83/ATP11C/IHH/ZAP70/IL15/BTN2A2 9 BP GO:0071359 cellular response to dsRNA 4/689 22/18670 0.007915 0.193 0.1791 IFIH1/MUL1/DDX58/RIOK3 4 BP GO:0002224 toll-like receptor signaling pathway 12/689 146/18670 0.00794 0.193 0.1791 TRAF3/IRF1/TNFAIP3/CTSK/RIPK2/WDFY1/TBK1/PELI1/TLR9/NR1D1/TAB1/PRKCE 12 BP GO:0014896 muscle hypertrophy 10/689 111/18670 0.007974 0.193 0.1791 PTK2/ATP2B4/ROCK2/LMCD1/BMP10/LEP/PDLIM5/MTPN/PDE5A/DDX39B 10 BP GO:0014743 regulation of muscle hypertrophy 8/689 78/18670 0.007985 0.193 0.1791 PTK2/ATP2B4/ROCK2/LMCD1/BMP10/MTPN/PDE5A/DDX39B 8 BP GO:0070664 negative regulation of leukocyte proliferation 8/689 78/18670 0.007985 0.193 0.1791 TNFAIP3/ARG2/PELI1/PDCD1LG2/PDE5A/TWSG1/IHH/BTN2A2 8 BP GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 6/689 48/18670 0.008114 0.1951 0.181 BMP8A/ACVR1/GDF9/BMP8B/BMP10/TWSG1 6 BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 17/689 241/18670 0.00829 0.1977 0.1835 PCSK6/VEPH1/BMP8A/ACVR1/RBPMS2/GDF9/ONECUT2/RASL11B/HES1/MIR26A1/THBS1/BMP8B/BMP10/CAV2/MSX1/ING2/TWSG1 17 BP GO:0045069 regulation of viral genome replication 9/689 95/18670 0.008418 0.1977 0.1835 CXCL8/RAD23A/STAU1/FAM111A/ZC3HAV1/ISG20/PABPC1/STOM/TRIM38 9 BP GO:0060337 type I interferon signaling pathway 9/689 95/18670 0.008418 0.1977 0.1835 GBP2/STAT1/IRF1/STAT2/EGR1/MUL1/TBK1/ISG20/IFIT3 9 BP GO:0071357 cellular response to type I interferon 9/689 95/18670 0.008418 0.1977 0.1835 GBP2/STAT1/IRF1/STAT2/EGR1/MUL1/TBK1/ISG20/IFIT3 9 BP GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 16/689 222/18670 0.008429 0.1977 0.1835 STAT1/CXCL8/GTF2F2/TRIM26/ZFP36/ZNF502/RAD23A/LAMP3/STAU1/FAM111A/ZC3HAV1/CAV2/ISG20/PABPC1/STOM/TRIM38 16 BP GO:0006527 arginine catabolic process 3/689 12/18670 0.008579 0.1983 0.184 ARG2/ATP2B4/NOS3 3 BP GO:0031507 heterochromatin assembly 3/689 12/18670 0.008579 0.1983 0.184 H3-3B/HMGA1/SMCHD1 3 BP GO:1904668 positive regulation of ubiquitin protein ligase activity 3/689 12/18670 0.008579 0.1983 0.184 CDC14B/MASTL/PLK1 3 BP GO:0042455 ribonucleoside biosynthetic process 5/689 35/18670 0.00875 0.2003 0.1858 NME4/PRTFDC1/APRT/NME7/UCK2 5 BP GO:0045070 positive regulation of viral genome replication 5/689 35/18670 0.00875 0.2003 0.1858 RAD23A/STAU1/PABPC1/STOM/TRIM38 5 BP GO:0032956 regulation of actin cytoskeleton organization 22/689 343/18670 0.008789 0.2003 0.1858 PHLDB2/TPM1/TMOD2/ICAM1/FSCN1/RHOBTB1/ARHGAP18/CTTN/PHPT1/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/HRAS/BMP10/TAOK1/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 22 BP GO:1901653 cellular response to peptide 24/689 385/18670 0.008946 0.2022 0.1876 ATP6V0A2/NR4A2/STAT1/ICAM1/APP/VAMP2/SOCS3/GPR21/ATP6V0E2/MAX/KLF10/RIPK2/LEPROT/KLF4/PTK2/CEACAM1/RAB31/ROCK2/APRT/LEP/CAV2/BCL2L2/KLF5/ATP6V1G2 24 BP GO:0032755 positive regulation of interleukin-6 production 9/689 96/18670 0.008995 0.2022 0.1876 APP/IFIH1/DDX58/RIPK2/SPON2/TLR9/C1QTNF4/CLEC7A/AIF1 9 BP GO:0043244 regulation of protein complex disassembly 10/689 113/18670 0.009001 0.2022 0.1876 TMOD2/UVRAG/MAP1A/RUBCN/TAOK1/VIL1/MTPN/CALCOCO2/TTBK2/SETX 10 BP GO:0030032 lamellipodium assembly 7/689 64/18670 0.009075 0.2029 0.1883 FSCN1/AUTS2/ABLIM3/NCK2/NCKAP1/P2RY12/WASF3 7 BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 12/689 149/18670 0.00927 0.2033 0.1887 ICAM1/APP/RIPK2/CLU/LRRFIP1/RNF31/TLR9/ROR1/MTPN/TAB1/TRAPPC9/TRIM38 12 BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 12/689 149/18670 0.00927 0.2033 0.1887 EGF/NUB1/PLK3/MAP1A/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/RNF19B/PLK1/TRIB1 12 BP GO:0009147 pyrimidine nucleoside triphosphate metabolic process 4/689 23/18670 0.009307 0.2033 0.1887 DCTPP1/NME4/NME7/UCK2 4 BP GO:0042451 purine nucleoside biosynthetic process 4/689 23/18670 0.009307 0.2033 0.1887 NME4/PRTFDC1/APRT/NME7 4 BP GO:0046129 purine ribonucleoside biosynthetic process 4/689 23/18670 0.009307 0.2033 0.1887 NME4/PRTFDC1/APRT/NME7 4 BP GO:0051591 response to cAMP 9/689 97/18670 0.0096 0.2088 0.1938 DUSP1/FOS/STAT1/APP/JUNB/PKD2/JUND/FOSB/ITPR2 9 BP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 8/689 81/18670 0.009955 0.2149 0.1994 NUB1/PLK3/CLU/ZFAND2A/RAD23A/RNF19B/PLK1/TRIB1 8 BP GO:0045619 regulation of lymphocyte differentiation 13/689 169/18670 0.01002 0.2149 0.1994 EGR3/NFKBIZ/IRF1/PRDX2/RIPK2/TLR9/CD83/ATP11C/IHH/ZAP70/LOXL3/IL15/BTN2A2 13 BP GO:0048660 regulation of smooth muscle cell proliferation 13/689 169/18670 0.01002 0.2149 0.1994 PTGS2/TPM1/STAT1/ADAMTS1/TNFAIP3/RBPMS2/KLF4/MIR26A1/THBS1/AIF1/TRIB1/IL15/DDX39B 13 BP GO:1904375 regulation of protein localization to cell periphery 10/689 115/18670 0.01013 0.2163 0.2007 RAMP3/GBP1/VTI1B/HRAS/CNPY4/VIL1/PRKCE/RAB11A/PLK1/SAPCD2 10 BP GO:0097237 cellular response to toxic substance 17/689 247/18670 0.01044 0.219 0.2032 PTGS2/GCH1/XRN1/EGR1/TNFAIP3/PRDX2/KLF4/CCL7/OPRD1/ITPR2/PTGS1/MSX1/PRKCE/NOS3/SETX/ZNF580/UBIAD1 17 BP GO:0071772 response to BMP 13/689 170/18670 0.01049 0.219 0.2032 PCSK6/BMP8A/EGR1/ACVR1/RBPMS2/GDF9/HES1/MIR26A1/BMP8B/BMP10/MSX1/SPINT2/TWSG1 13 BP GO:0071773 cellular response to BMP stimulus 13/689 170/18670 0.01049 0.219 0.2032 PCSK6/BMP8A/EGR1/ACVR1/RBPMS2/GDF9/HES1/MIR26A1/BMP8B/BMP10/MSX1/SPINT2/TWSG1 13 BP GO:0019058 viral life cycle 21/689 328/18670 0.01051 0.219 0.2032 UVRAG/CXCL8/ICAM1/TRIM26/NUP188/ZNF502/RAD23A/LAMP3/STAU1/FAM111A/ROCK2/ZC3HAV1/ITGB5/CAV2/USP6NL/ISG20/PABPC1/STOM/ITGB3/TRIM38/TNFRSF4 21 BP GO:0051926 negative regulation of calcium ion transport 7/689 66/18670 0.01068 0.219 0.2032 PTGS2/SESTD1/ICAM1/PKD2/TLR9/BIN1/NOS3 7 BP GO:0050687 negative regulation of defense response to virus 4/689 24/18670 0.01085 0.219 0.2032 MUL1/RIOK3/GPATCH3/TRIM38 4 BP GO:0006596 polyamine biosynthetic process 3/689 13/18670 0.01085 0.219 0.2032 SAT1/ODC1/SMOX 3 BP GO:0010459 negative regulation of heart rate 3/689 13/18670 0.01085 0.219 0.2032 MIR26A1/SPX/RNLS 3 BP GO:0014745 negative regulation of muscle adaptation 3/689 13/18670 0.01085 0.219 0.2032 KLF4/ATP2B4/NOS3 3 BP GO:0032530 regulation of microvillus organization 3/689 13/18670 0.01085 0.219 0.2032 FSCN1/VIL1/KLF5 3 BP GO:0033623 regulation of integrin activation 3/689 13/18670 0.01085 0.219 0.2032 RASIP1/P2RY12/SELP 3 BP GO:0051001 negative regulation of nitric-oxide synthase activity 3/689 13/18670 0.01085 0.219 0.2032 MIR26A1/ATP2B4/CNR2 3 BP GO:0050999 regulation of nitric-oxide synthase activity 6/689 51/18670 0.01085 0.219 0.2032 GCH1/MIR26A1/ATP2B4/CNR2/LEP/NOS3 6 BP GO:0034340 response to type I interferon 9/689 99/18670 0.0109 0.219 0.2032 GBP2/STAT1/IRF1/STAT2/EGR1/MUL1/TBK1/ISG20/IFIT3 9 BP GO:0006937 regulation of muscle contraction 13/689 171/18670 0.01099 0.219 0.2032 PTGS2/TPM1/PDE4B/ADRA1B/CTTN/CCN2/SPX/BMP10/MYL9/GUCY1A1/PDE5A/BIN1/EHD3 13 BP GO:0048659 smooth muscle cell proliferation 13/689 171/18670 0.01099 0.219 0.2032 PTGS2/TPM1/STAT1/ADAMTS1/TNFAIP3/RBPMS2/KLF4/MIR26A1/THBS1/AIF1/TRIB1/IL15/DDX39B 13 BP GO:0050691 regulation of defense response to virus by host 5/689 37/18670 0.01106 0.2196 0.2038 STAT1/TNFAIP3/MUL1/DDX58/IL15 5 BP GO:0042133 neurotransmitter metabolic process 12/689 153/18670 0.0113 0.2235 0.2074 PTGS2/GCH1/ICAM1/PKD2/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/AIF1/NOS3 12 BP GO:0006970 response to osmotic stress 8/689 83/18670 0.01146 0.2253 0.2091 PTGS2/SLC2A1/PLK3/PKD2/TSC22D2/TSC22D3/MYLK/LRRC8E 8 BP GO:0043434 response to peptide hormone 26/689 436/18670 0.01149 0.2253 0.2091 PTGS2/EGR2/ATP6V0A2/NR4A2/STAT1/BTG2/SLC2A1/ICAM1/VAMP2/SOCS3/STAT2/EGR1/JUND/GPR21/ATP6V0E2/MAX/LEPROT/PTK2/CEACAM1/RAB31/CCN2/ROCK2/APRT/LEP/CAV2/ATP6V1G2 26 BP GO:0042108 positive regulation of cytokine biosynthetic process 7/689 67/18670 0.01156 0.2258 0.2095 APP/IRF1/EGR1/TBK1/THBS1/TLR9/CLEC7A 7 BP GO:0050885 neuromuscular process controlling balance 6/689 52/18670 0.0119 0.2314 0.2147 NBN/APP/NKX6-2/CAMTA1/RBFOX2/CDH23 6 BP GO:0008016 regulation of heart contraction 17/689 251/18670 0.0121 0.2345 0.2176 TPM1/GCH1/PDE4B/ADRA1B/MIR26A1/ATP2B4/CCN2/SPX/ITPR2/BMP10/RNLS/TMEM65/PDE5A/BIN1/EHD3/NOS3/THRA 17 BP GO:1902105 regulation of leukocyte differentiation 18/689 272/18670 0.0125 0.2411 0.2237 EGR3/FOS/NFKBIZ/IRF1/PRDX2/KLF10/RIPK2/FBXW7/CEACAM1/TLR9/CD83/ATP11C/IHH/TRIB1/ZAP70/LOXL3/IL15/BTN2A2 18 BP GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 4/689 25/18670 0.01255 0.2411 0.2237 TNFAIP3/PRDX2/TRIB1/SIGIRR 4 BP GO:0030195 negative regulation of blood coagulation 6/689 53/18670 0.01301 0.249 0.2311 PLG/SERPING1/CEACAM1/GP1BA/THBS1/NOS3 6 BP GO:0006241 CTP biosynthetic process 3/689 14/18670 0.01344 0.2521 0.2339 NME4/NME7/UCK2 3 BP GO:0006896 Golgi to vacuole transport 3/689 14/18670 0.01344 0.2521 0.2339 VTI1B/ANKFY1/EHD3 3 BP GO:0046036 CTP metabolic process 3/689 14/18670 0.01344 0.2521 0.2339 NME4/NME7/UCK2 3 BP GO:0071361 cellular response to ethanol 3/689 14/18670 0.01344 0.2521 0.2339 CCL7/ITPR2/PRKCE 3 BP GO:2000345 regulation of hepatocyte proliferation 3/689 14/18670 0.01344 0.2521 0.2339 TNFAIP3/FBXW7/CEACAM1 3 BP GO:0030509 BMP signaling pathway 12/689 157/18670 0.01367 0.2554 0.237 PCSK6/BMP8A/EGR1/ACVR1/RBPMS2/GDF9/HES1/MIR26A1/BMP8B/BMP10/MSX1/TWSG1 12 BP GO:0045580 regulation of T cell differentiation 11/689 139/18670 0.01403 0.2612 0.2424 EGR3/NFKBIZ/IRF1/PRDX2/RIPK2/CD83/IHH/ZAP70/LOXL3/IL15/BTN2A2 11 BP GO:0006636 unsaturated fatty acid biosynthetic process 6/689 54/18670 0.01419 0.2622 0.2433 PTGS2/PTGDS/ELOVL4/SCD5/AKR1C3/PTGS1 6 BP GO:1900047 negative regulation of hemostasis 6/689 54/18670 0.01419 0.2622 0.2433 PLG/SERPING1/CEACAM1/GP1BA/THBS1/NOS3 6 BP GO:0030194 positive regulation of blood coagulation 4/689 26/18670 0.0144 0.2641 0.245 PLG/PRDX2/THBS1/SELP 4 BP GO:1900048 positive regulation of hemostasis 4/689 26/18670 0.0144 0.2641 0.245 PLG/PRDX2/THBS1/SELP 4 BP GO:1901800 positive regulation of proteasomal protein catabolic process 9/689 104/18670 0.01474 0.2678 0.2485 NUB1/PLK3/CLU/ZFAND2A/RAD23A/FBXW7/RNF19B/PLK1/TRIB1 9 BP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 9/689 104/18670 0.01474 0.2678 0.2485 ICAM1/TNFAIP3/PRDX2/ACVR1/CTTN/FAIM/THBS1/MCL1/NOS3 9 BP GO:0006936 muscle contraction 22/689 360/18670 0.01477 0.2678 0.2485 PTGS2/TPM1/TMOD2/PDE4B/MYOM1/ADRA1B/CTTN/ARG2/CALD1/ATP2B4/MYLK/CCN2/ROCK2/SPX/BMP10/MYL9/ITGB5/GUCY1A1/PDE5A/BIN1/MYOF/EHD3 22 BP GO:0019079 viral genome replication 10/689 122/18670 0.01492 0.2684 0.2491 CXCL8/RAD23A/STAU1/FAM111A/ROCK2/ZC3HAV1/ISG20/PABPC1/STOM/TRIM38 10 BP GO:1905477 positive regulation of protein localization to membrane 10/689 122/18670 0.01492 0.2684 0.2491 PMAIP1/RAMP3/YWHAH/PDCD5/HRAS/CNPY4/VIL1/STOM/PRKCE/RAB11A 10 BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 16/689 237/18670 0.01505 0.2687 0.2494 STAT1/TNFAIP3/MUL1/RIOK3/RIPK2/TLE1/TBK1/PELI1/RNF31/PIM2/TLR9/ROR1/NR1D1/PRKCE/TRIM38/PLEKHG5 16 BP GO:0002758 innate immune response-activating signal transduction 19/689 298/18670 0.01505 0.2687 0.2494 TRAF3/IRF1/TNFAIP3/IFIH1/CTSK/DDX58/RIOK3/RIPK2/WDFY1/GPATCH3/TBK1/PELI1/TLR9/HRAS/CLEC7A/NR1D1/TAB1/PRKCE/DDX60 19 BP GO:0071470 cellular response to osmotic stress 5/689 40/18670 0.01526 0.2715 0.2519 PTGS2/SLC2A1/PKD2/MYLK/LRRC8E 5 BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 15/689 218/18670 0.01557 0.2757 0.2558 EGR3/NFKBIZ/ICAM1/SIRPB1/RIPK2/NCK2/HES1/PDCD1LG2/LEP/CD83/AIF1/IHH/ZAP70/IL15/BTN2A2 15 BP GO:0008064 regulation of actin polymerization or depolymerization 13/689 179/18670 0.01561 0.2757 0.2558 TMOD2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 13 BP GO:0007519 skeletal muscle tissue development 12/689 160/18670 0.01567 0.2757 0.2558 EGR2/FOS/BTG2/EGR1/MYOM1/PITX1/SELENON/SMYD1/HOXD9/XK/CAV2/KLF5 12 BP GO:2001233 regulation of apoptotic signaling pathway 24/689 406/18670 0.01625 0.2777 0.2577 G0S2/PTGS2/PMAIP1/NR4A2/ICAM1/TNFAIP3/YWHAH/MUL1/PRDX2/ACVR1/CTTN/CLU/NCK2/CHCHD10/FBXW7/FAIM/PDCD5/THBS1/MCL1/TAF9B/MSX1/ING2/NOS3/BCL2L2 24 BP GO:0030832 regulation of actin filament length 13/689 180/18670 0.01628 0.2777 0.2577 TMOD2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 13 BP GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 3/689 15/18670 0.01634 0.2777 0.2577 NME4/NME7/UCK2 3 BP GO:0043101 purine-containing compound salvage 3/689 15/18670 0.01634 0.2777 0.2577 GMPR/PRTFDC1/APRT 3 BP GO:0043652 engulfment of apoptotic cell 3/689 15/18670 0.01634 0.2777 0.2577 RHOBTB1/THBS1/RHOBTB2 3 BP GO:0045073 regulation of chemokine biosynthetic process 3/689 15/18670 0.01634 0.2777 0.2577 APP/EGR1/SIGIRR 3 BP GO:0032635 interleukin-6 production 12/689 161/18670 0.01639 0.2777 0.2577 APP/TNFAIP3/IFIH1/DDX58/RIPK2/MIR26A1/SPON2/TLR9/C1QTNF4/CLEC7A/LEP/AIF1 12 BP GO:0007176 regulation of epidermal growth factor-activated receptor activity 4/689 27/18670 0.01643 0.2777 0.2577 EGF/APP/NCK2/FBXW7 4 BP GO:0045932 negative regulation of muscle contraction 4/689 27/18670 0.01643 0.2777 0.2577 PTGS2/GUCY1A1/PDE5A/BIN1 4 BP GO:0050820 positive regulation of coagulation 4/689 27/18670 0.01643 0.2777 0.2577 PLG/PRDX2/THBS1/SELP 4 BP GO:0072378 blood coagulation, fibrin clot formation 4/689 27/18670 0.01643 0.2777 0.2577 F13A1/SERPING1/SERPINC1/GP1BA 4 BP GO:0050708 regulation of protein secretion 27/689 472/18670 0.01667 0.2788 0.2587 GBP1/SLC2A1/OSM/BMP8A/TNFAIP3/MYOM1/IFIH1/DDX58/GLUL/RIPK2/ARG2/PANX1/PHPT1/C5/RHBDF2/CDK16/TLR9/C1QTNF4/ITPR2/LEP/SYTL4/NR1D1/AIF1/SIRT3/PRKCE/TNFRSF4/BTN2A2 27 BP GO:1903747 regulation of establishment of protein localization to mitochondrion 7/689 72/18670 0.01675 0.2788 0.2587 PMAIP1/YWHAH/LEPROT/ABLIM3/FBXW7/RNF31/PDCD5 7 BP GO:0030217 T cell differentiation 16/689 240/18670 0.01676 0.2788 0.2587 EGR3/NFKBIZ/IRF1/EGR1/PRDX2/JMJD6/RIPK2/LEPR/LEP/CD83/IHH/ZAP70/LOXL3/IL15/BTN2A2/BATF 16 BP GO:0050663 cytokine secretion 16/689 240/18670 0.01676 0.2788 0.2587 GBP1/OSM/GBP5/TNFAIP3/IFIH1/DDX58/RIPK2/ARG2/PANX1/C5/TLR9/C1QTNF4/LEP/AIF1/TNFRSF4/BTN2A2 16 BP GO:0032615 interleukin-12 production 6/689 56/18670 0.01678 0.2788 0.2587 IRF1/RIPK2/THBS1/TLR9/CLEC7A/LEP 6 BP GO:0032465 regulation of cytokinesis 8/689 89/18670 0.01695 0.2807 0.2604 UVRAG/PLK3/CDC14B/PRPF40A/PRKCE/RXFP3/RAB11A/PLK1 8 BP GO:0006979 response to oxidative stress 26/689 451/18670 0.01701 0.2807 0.2604 PTGS2/TPM1/DUSP1/NR4A2/FOS/GCH1/STAT1/APP/PLK3/PKD2/GUCY1B1/TNFAIP3/OGG1/PRDX2/PDLIM1/AKR1C3/KLF4/FBXW7/SELENON/STAU1/MCL1/PTGS1/AIF1/NOS3/SETX/ZNF580 26 BP GO:0110053 regulation of actin filament organization 17/689 261/18670 0.01718 0.2826 0.2622 PHLDB2/TPM1/TMOD2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 17 BP GO:0008217 regulation of blood pressure 13/689 182/18670 0.01769 0.2898 0.2689 PTGS2/TPM1/GCH1/ADRA1B/UTS2B/SPX/ADRB3/RNLS/LEP/PTGS1/SGK1/GUCY1A1/NOS3 13 BP GO:0032970 regulation of actin filament-based process 23/689 388/18670 0.01784 0.2907 0.2697 PHLDB2/TPM1/TMOD2/PDE4B/ICAM1/FSCN1/RHOBTB1/ARHGAP18/CTTN/PHPT1/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/HRAS/BMP10/TAOK1/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 23 BP GO:0032945 negative regulation of mononuclear cell proliferation 7/689 73/18670 0.01795 0.2907 0.2697 ARG2/PELI1/PDCD1LG2/PDE5A/TWSG1/IHH/BTN2A2 7 BP GO:0050672 negative regulation of lymphocyte proliferation 7/689 73/18670 0.01795 0.2907 0.2697 ARG2/PELI1/PDCD1LG2/PDE5A/TWSG1/IHH/BTN2A2 7 BP GO:0050870 positive regulation of T cell activation 14/689 202/18670 0.01798 0.2907 0.2697 EGR3/NFKBIZ/SIRPB1/RIPK2/NCK2/HES1/PDCD1LG2/LEP/CD83/AIF1/IHH/ZAP70/IL15/BTN2A2 14 BP GO:0050819 negative regulation of coagulation 6/689 57/18670 0.01819 0.2921 0.271 PLG/SERPING1/CEACAM1/GP1BA/THBS1/NOS3 6 BP GO:0042181 ketone biosynthetic process 5/689 42/18670 0.01858 0.2921 0.271 EGR1/AKR1C3/PPTC7/COQ4/UBIAD1 5 BP GO:0001516 prostaglandin biosynthetic process 4/689 28/18670 0.01862 0.2921 0.271 PTGS2/PTGDS/AKR1C3/PTGS1 4 BP GO:0009065 glutamine family amino acid catabolic process 4/689 28/18670 0.01862 0.2921 0.271 GLUL/ARG2/ATP2B4/NOS3 4 BP GO:0042730 fibrinolysis 4/689 28/18670 0.01862 0.2921 0.271 PLG/SERPING1/GP1BA/THBS1 4 BP GO:0046457 prostanoid biosynthetic process 4/689 28/18670 0.01862 0.2921 0.271 PTGS2/PTGDS/AKR1C3/PTGS1 4 BP GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 4/689 28/18670 0.01862 0.2921 0.271 GBP1/PHPT1/CEACAM1/BTN2A2 4 BP GO:1902003 regulation of amyloid-beta formation 4/689 28/18670 0.01862 0.2921 0.271 APP/CLU/ROCK2/BIN1 4 BP GO:1902745 positive regulation of lamellipodium organization 4/689 28/18670 0.01862 0.2921 0.271 FSCN1/AUTS2/NCKAP1/VIL1 4 BP GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 3/689 16/18670 0.01957 0.2954 0.2741 NME4/NME7/UCK2 3 BP GO:0010566 regulation of ketone biosynthetic process 3/689 16/18670 0.01957 0.2954 0.2741 EGR1/AKR1C3/PPTC7 3 BP GO:0042033 chemokine biosynthetic process 3/689 16/18670 0.01957 0.2954 0.2741 APP/EGR1/SIGIRR 3 BP GO:0043174 nucleoside salvage 3/689 16/18670 0.01957 0.2954 0.2741 PRTFDC1/APRT/UCK2 3 BP GO:0044794 positive regulation by host of viral process 3/689 16/18670 0.01957 0.2954 0.2741 ZNF502/CAV2/STOM 3 BP GO:0050755 chemokine metabolic process 3/689 16/18670 0.01957 0.2954 0.2741 APP/EGR1/SIGIRR 3 BP GO:0051382 kinetochore assembly 3/689 16/18670 0.01957 0.2954 0.2741 RNF4/CENPC/CENPS 3 BP GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 3/689 16/18670 0.01957 0.2954 0.2741 SPPL3/LMCD1/CAMTA1 3 BP GO:0071871 response to epinephrine 3/689 16/18670 0.01957 0.2954 0.2741 PDE4B/ATP2B4/RNLS 3 BP GO:0090335 regulation of brown fat cell differentiation 3/689 16/18670 0.01957 0.2954 0.2741 PTGS2/METRNL/LEP 3 BP GO:0106058 positive regulation of calcineurin-mediated signaling 3/689 16/18670 0.01957 0.2954 0.2741 SPPL3/LMCD1/CAMTA1 3 BP GO:1902004 positive regulation of amyloid-beta formation 3/689 16/18670 0.01957 0.2954 0.2741 APP/CLU/ROCK2 3 BP GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/689 58/18670 0.01967 0.296 0.2747 PMAIP1/ICAM1/TNFAIP3/FAIM/THBS1/NOS3 6 BP GO:0071222 cellular response to lipopolysaccharide 14/689 205/18670 0.02015 0.3023 0.2805 CXCL8/PDE4B/ICAM1/TNFAIP3/ZFP36/PRDX2/RIPK2/PDCD1LG2/SPON2/NR1D1/PRKCE/NOS3/TRIB1/SIGIRR 14 BP GO:0009163 nucleoside biosynthetic process 5/689 43/18670 0.02041 0.3042 0.2822 NME4/PRTFDC1/APRT/NME7/UCK2 5 BP GO:0050850 positive regulation of calcium-mediated signaling 5/689 43/18670 0.02041 0.3042 0.2822 PKD2/SPPL3/LMCD1/CAMTA1/ZAP70 5 BP GO:0071236 cellular response to antibiotic 11/689 147/18670 0.02047 0.3042 0.2822 XRN1/EGR1/TNFAIP3/CLU/KLF4/CCL7/ID3/ITPR2/PRKCE/SETX/ZNF580 11 BP GO:0051495 positive regulation of cytoskeleton organization 15/689 226/18670 0.02085 0.3089 0.2867 TPM1/ICAM1/RHOBTB1/CTTN/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/HRAS/BMP10/VIL1/RHOBTB2/BIN1/PRKCE 15 BP GO:0050867 positive regulation of cell activation 23/689 394/18670 0.02092 0.3089 0.2867 EGR3/NFKBIZ/SIRPB1/RIPK2/NCK2/PELI1/HES1/PDCD1LG2/THBS1/TLR9/CCN2/MPL/CLEC7A/LEP/SELP/CD83/ATP11C/AIF1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 23 BP GO:0070102 interleukin-6-mediated signaling pathway 4/689 29/18670 0.02098 0.3089 0.2867 STAT1/SOCS3/MIR26A1/C1QTNF4 4 BP GO:0030099 myeloid cell differentiation 24/689 416/18670 0.02109 0.3095 0.2872 FOS/STAT1/APP/JUNB/MT1G/ZFP36/JMJD6/KLF10/H3-3B/FBXW7/SMAP1/CEACAM1/GP1BA/THBS1/MPL/MYL9/H4C8/TRIB1/MOV10/IL15/THRA/RBFOX2/BATF/CLEC1B 24 BP GO:0045824 negative regulation of innate immune response 6/689 59/18670 0.02124 0.3099 0.2875 TNFAIP3/MUL1/PARP14/TRAFD1/SERPING1/CEACAM1 6 BP GO:0070527 platelet aggregation 6/689 59/18670 0.02124 0.3099 0.2875 CEACAM1/GP1BA/P2RY12/MPL/MYL9/ITGB3 6 BP GO:1903362 regulation of cellular protein catabolic process 16/689 247/18670 0.02133 0.3103 0.2879 EGF/NUB1/PLK3/TNFAIP3/MAP1A/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/LAMP3/USP25/RNF19B/PLK1/TRIB1/LAPTM4B 16 BP GO:0031668 cellular response to extracellular stimulus 17/689 268/18670 0.02162 0.3135 0.2909 PTGS2/PMAIP1/NR4A2/FOS/SLC2A1/ICAM1/NPRL2/DCTPP1/MAX/KLF10/GLUL/AKR1C3/CASTOR1/P2RY12/LEP/AIF1/IL15 17 BP GO:0061045 negative regulation of wound healing 7/689 76/18670 0.02194 0.3171 0.2943 PHLDB2/PLG/SERPING1/CEACAM1/GP1BA/THBS1/NOS3 7 BP GO:0034614 cellular response to reactive oxygen species 12/689 168/18670 0.02211 0.3186 0.2957 TPM1/FOS/GCH1/PKD2/GUCY1B1/TNFAIP3/PRDX2/AKR1C3/KLF4/NOS3/SETX/ZNF580 12 BP GO:0061756 leukocyte adhesion to vascular endothelial cell 5/689 44/18670 0.02235 0.3202 0.2971 ICAM1/KLF4/LEP/SELP/CCL28 5 BP GO:1903214 regulation of protein targeting to mitochondrion 5/689 44/18670 0.02235 0.3202 0.2971 LEPROT/ABLIM3/FBXW7/RNF31/PDCD5 5 BP GO:0003015 heart process 18/689 290/18670 0.02244 0.3202 0.2971 TPM1/RAMP3/GCH1/PDE4B/ADRA1B/MIR26A1/ATP2B4/CCN2/SPX/ITPR2/BMP10/RNLS/TMEM65/PDE5A/BIN1/EHD3/NOS3/THRA 18 BP GO:0060538 skeletal muscle organ development 12/689 169/18670 0.02303 0.3202 0.2971 EGR2/FOS/BTG2/EGR1/MYOM1/PITX1/SELENON/SMYD1/HOXD9/XK/CAV2/KLF5 12 BP GO:0006595 polyamine metabolic process 3/689 17/18670 0.02313 0.3202 0.2971 SAT1/ODC1/SMOX 3 BP GO:0006744 ubiquinone biosynthetic process 3/689 17/18670 0.02313 0.3202 0.2971 PPTC7/COQ4/UBIAD1 3 BP GO:0032460 negative regulation of protein oligomerization 3/689 17/18670 0.02313 0.3202 0.2971 RIOK3/CLU/OPRD1 3 BP GO:0046068 cGMP metabolic process 3/689 17/18670 0.02313 0.3202 0.2971 GUCY1B1/GUCY1A1/PDE5A 3 BP GO:0071360 cellular response to exogenous dsRNA 3/689 17/18670 0.02313 0.3202 0.2971 IFIH1/MUL1/DDX58 3 BP GO:0071850 mitotic cell cycle arrest 3/689 17/18670 0.02313 0.3202 0.2971 DUSP1/CDC14B/GADD45GIP1 3 BP GO:1901663 quinone biosynthetic process 3/689 17/18670 0.02313 0.3202 0.2971 PPTC7/COQ4/UBIAD1 3 BP GO:2000811 negative regulation of anoikis 3/689 17/18670 0.02313 0.3202 0.2971 TLE1/PTK2/MCL1 3 BP GO:0010632 regulation of epithelial cell migration 18/689 291/18670 0.02313 0.3202 0.2971 PTGS2/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/VIL1/PRKCE/ITGB3/RAB11A/NOS3/MIR22/ZNF580 18 BP GO:0010594 regulation of endothelial cell migration 15/689 229/18670 0.02315 0.3202 0.2971 PTGS2/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/ITGB3/NOS3/MIR22/ZNF580 15 BP GO:0032743 positive regulation of interleukin-2 production 4/689 30/18670 0.02352 0.3243 0.301 PDE4B/RIPK2/CLEC7A/CD83 4 BP GO:0051251 positive regulation of lymphocyte activation 20/689 334/18670 0.02359 0.3243 0.301 EGR3/NFKBIZ/SIRPB1/RIPK2/NCK2/PELI1/HES1/PDCD1LG2/TLR9/MPL/CLEC7A/LEP/CD83/ATP11C/AIF1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 20 BP GO:2001234 negative regulation of apoptotic signaling pathway 15/689 230/18670 0.02396 0.3279 0.3043 PTGS2/NR4A2/ICAM1/TNFAIP3/PRDX2/ACVR1/CTTN/CLU/FAIM/THBS1/MCL1/TAF9B/ING2/NOS3/BCL2L2 15 BP GO:0043433 negative regulation of DNA-binding transcription factor activity 12/689 170/18670 0.02398 0.3279 0.3043 TRAF3/PKD2/TNFAIP3/PRDX2/KLF4/ID3/PELI1/MIR26A1/TLR9/TRIB1/SIGIRR/TNFRSF4 12 BP GO:0042102 positive regulation of T cell proliferation 8/689 95/18670 0.02414 0.3285 0.3048 RIPK2/NCK2/HES1/PDCD1LG2/LEP/AIF1/ZAP70/IL15 8 BP GO:0050707 regulation of cytokine secretion 14/689 210/18670 0.0242 0.3285 0.3048 GBP1/OSM/TNFAIP3/IFIH1/DDX58/RIPK2/ARG2/PANX1/C5/TLR9/C1QTNF4/AIF1/TNFRSF4/BTN2A2 14 BP GO:0050678 regulation of epithelial cell proliferation 22/689 378/18670 0.02423 0.3285 0.3048 EGR3/STAT1/TNFAIP3/ZFP36/GLUL/CYP7B1/FBXW7/HES1/CEACAM1/MIR26A1/THBS1/HRAS/DLX6/LEP/MIR129-1/CAV2/NR1D1/ITGB3/IHH/MIR22/SAV1/ZNF580 22 BP GO:0045637 regulation of myeloid cell differentiation 16/689 251/18670 0.02434 0.3289 0.3052 FOS/STAT1/ZFP36/KLF10/H3-3B/FBXW7/SMAP1/CEACAM1/GP1BA/THBS1/MPL/MYL9/H4C8/TRIB1/MOV10/RBFOX2 16 BP GO:0007015 actin filament organization 23/689 400/18670 0.0244 0.3289 0.3052 PHLDB2/TPM1/TMOD2/PSTPIP2/ICAM1/FSCN1/MYOM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/CCN2/ACTR3B/ROCK2/ITGB5/VIL1/MTPN/WASF3/RHOBTB2/AIF1/BIN1/PRKCE 23 BP GO:0032868 response to insulin 17/689 272/18670 0.02453 0.3297 0.3059 EGR2/ATP6V0A2/STAT1/SLC2A1/ICAM1/VAMP2/SOCS3/EGR1/GPR21/ATP6V0E2/MAX/CEACAM1/RAB31/APRT/LEP/CAV2/ATP6V1G2 17 BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 6/689 61/18670 0.02462 0.33 0.3062 NFKBIZ/RIPK2/ARG2/CD83/TWSG1/LOXL3 6 BP GO:1903313 positive regulation of mRNA metabolic process 7/689 78/18670 0.02491 0.3328 0.3088 BTG2/ZFP36/ROCK2/ZC3HAV1/AGO2/PABPC1/MOV10 7 BP GO:0016241 regulation of macroautophagy 12/689 171/18670 0.02497 0.3328 0.3088 ATP6V0A2/UVRAG/NPRL2/PRKAG2/ATP6V0E2/RIPK2/LAMTOR1/TBK1/PIM2/RUBCN/CALCOCO2/ATP6V1G2 12 BP GO:0043542 endothelial cell migration 17/689 273/18670 0.0253 0.3362 0.312 PTGS2/EGR3/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/ITGB3/NOS3/PLEKHG5/MIR22/ZNF580 17 BP GO:0032675 regulation of interleukin-6 production 11/689 152/18670 0.02546 0.3364 0.3122 APP/TNFAIP3/IFIH1/DDX58/RIPK2/MIR26A1/SPON2/TLR9/C1QTNF4/CLEC7A/AIF1 11 BP GO:0000302 response to reactive oxygen species 15/689 232/18670 0.02564 0.3364 0.3122 TPM1/DUSP1/FOS/GCH1/STAT1/PLK3/PKD2/GUCY1B1/TNFAIP3/PRDX2/AKR1C3/KLF4/NOS3/SETX/ZNF580 15 BP GO:0140013 meiotic nuclear division 12/689 172/18670 0.02598 0.3364 0.3122 PDE3A/MOS/TDRKH/CENPC/CENPS/DMC1/REC8/MSX1/RAD54B/MASTL/ING2/PLK1 12 BP GO:0071219 cellular response to molecule of bacterial origin 14/689 212/18670 0.02598 0.3364 0.3122 CXCL8/PDE4B/ICAM1/TNFAIP3/ZFP36/PRDX2/RIPK2/PDCD1LG2/SPON2/NR1D1/PRKCE/NOS3/TRIB1/SIGIRR 14 BP GO:0045089 positive regulation of innate immune response 22/689 381/18670 0.02618 0.3364 0.3122 TRAF3/IRF1/GBP5/TNFAIP3/IFIH1/CTSK/DDX58/RIOK3/RIPK2/WDFY1/GPATCH3/TBK1/PELI1/TLR9/HRAS/CLEC7A/POLR3G/NR1D1/TAB1/PRKCE/SH2D1B/DDX60 22 BP GO:0031572 G2 DNA damage checkpoint 4/689 31/18670 0.02624 0.3364 0.3122 NBN/CDC14B/TAOK1/PLK1 4 BP GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 4/689 31/18670 0.02624 0.3364 0.3122 ADRA1B/ATP2B4/ADRB3/OR56A1 4 BP GO:0045785 positive regulation of cell adhesion 23/689 403/18670 0.02631 0.3364 0.3122 TPM1/EGR3/NFKBIZ/ICAM1/FBLN2/GCNT2/SIRPB1/EMILIN2/RIPK2/NCK2/HES1/PDCD1LG2/P2RY12/MMRN1/LEP/CD83/AIF1/PRKCE/IHH/ZAP70/IL15/CCL28/BTN2A2 23 BP GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 6/689 62/18670 0.02644 0.3364 0.3122 BMP8A/ACVR1/GDF9/BMP8B/BMP10/TWSG1 6 BP GO:0032612 interleukin-1 production 9/689 115/18670 0.02653 0.3364 0.3122 APP/GBP5/EGR1/TNFAIP3/RIPK2/ARG2/PANX1/CEACAM1/CLEC7A 9 BP GO:0090316 positive regulation of intracellular protein transport 11/689 153/18670 0.02656 0.3364 0.3122 PTGS2/VAMP2/PLK3/LEPROT/ABLIM3/FBXW7/RNF31/PDCD5/HRAS/LEP/STOM 11 BP GO:0006221 pyrimidine nucleotide biosynthetic process 5/689 46/18670 0.02658 0.3364 0.3122 NME4/GPAM/AGPAT1/NME7/UCK2 5 BP GO:0022602 ovulation cycle process 5/689 46/18670 0.02658 0.3364 0.3122 ADAMTS1/GDF9/LEP/NRIP1/NOS3 5 BP GO:0031648 protein destabilization 5/689 46/18670 0.02658 0.3364 0.3122 MUL1/RAD23A/FBXW7/NR1D1/PLK1 5 BP GO:0032480 negative regulation of type I interferon production 5/689 46/18670 0.02658 0.3364 0.3122 TNFAIP3/IFIH1/DDX58/GPATCH3/TBK1 5 BP GO:0043277 apoptotic cell clearance 5/689 46/18670 0.02658 0.3364 0.3122 RHOBTB1/JMJD6/THBS1/RHOBTB2/ITGB3 5 BP GO:0048599 oocyte development 5/689 46/18670 0.02658 0.3364 0.3122 PDE3A/GDF9/DMC1/REC8/PDE5A 5 BP GO:0071354 cellular response to interleukin-6 5/689 46/18670 0.02658 0.3364 0.3122 STAT1/ICAM1/SOCS3/MIR26A1/C1QTNF4 5 BP GO:0051924 regulation of calcium ion transport 16/689 254/18670 0.02679 0.3365 0.3123 PTGS2/SESTD1/RAMP3/EGF/PDE4B/ICAM1/PKD2/SELENON/OPRD1/MYLK/P2RY12/TLR9/BIN1/PRKCE/EHD3/NOS3 16 BP GO:0032273 positive regulation of protein polymerization 10/689 134/18670 0.0268 0.3365 0.3123 ICAM1/RHOBTB1/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/RHOBTB2/BIN1/PRKCE 10 BP GO:0006743 ubiquinone metabolic process 3/689 18/18670 0.02701 0.3365 0.3123 PPTC7/COQ4/UBIAD1 3 BP GO:0007597 blood coagulation, intrinsic pathway 3/689 18/18670 0.02701 0.3365 0.3123 SERPING1/SERPINC1/GP1BA 3 BP GO:0072574 hepatocyte proliferation 3/689 18/18670 0.02701 0.3365 0.3123 TNFAIP3/FBXW7/CEACAM1 3 BP GO:0072575 epithelial cell proliferation involved in liver morphogenesis 3/689 18/18670 0.02701 0.3365 0.3123 TNFAIP3/FBXW7/CEACAM1 3 BP GO:0022409 positive regulation of cell-cell adhesion 16/689 255/18670 0.02765 0.3437 0.3189 EGR3/NFKBIZ/ICAM1/GCNT2/SIRPB1/RIPK2/NCK2/HES1/PDCD1LG2/LEP/CD83/AIF1/IHH/ZAP70/IL15/BTN2A2 16 BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 14/689 214/18670 0.02785 0.3439 0.3191 EGF/NUB1/PLK3/MAP1A/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/LAMP3/USP25/RNF19B/PLK1/TRIB1 14 BP GO:0002218 activation of innate immune response 19/689 319/18670 0.02816 0.3439 0.3191 TRAF3/IRF1/TNFAIP3/IFIH1/CTSK/DDX58/RIOK3/RIPK2/WDFY1/GPATCH3/TBK1/PELI1/TLR9/HRAS/CLEC7A/NR1D1/TAB1/PRKCE/DDX60 19 BP GO:0046637 regulation of alpha-beta T cell differentiation 6/689 63/18670 0.02835 0.3439 0.3191 NFKBIZ/RIPK2/CD83/IHH/ZAP70/LOXL3 6 BP GO:0044843 cell cycle G1/S phase transition 18/689 298/18670 0.02842 0.3439 0.3191 BTG2/ADAMTS1/PLK3/PLAGL1/PKD2/MAX/ACVR1/FHL1/KLF4/FBXW7/RCC1/CTDSPL/MIR26A1/ATP2B4/PIM2/TFDP3/AIF1/BTN2A2 18 BP GO:0050848 regulation of calcium-mediated signaling 8/689 98/18670 0.02843 0.3439 0.3191 GBP1/PKD2/SELENON/ATP2B4/SPPL3/LMCD1/CAMTA1/ZAP70 8 BP GO:0010810 regulation of cell-substrate adhesion 14/689 215/18670 0.02883 0.3439 0.3191 PHLDB2/SLK/GBP1/FBLN2/GCNT2/EMILIN2/PLG/PTK2/ONECUT2/THBS1/ROCK2/MMRN1/PRKCE/CCL28 14 BP GO:1903707 negative regulation of hemopoiesis 11/689 155/18670 0.02886 0.3439 0.3191 IRF1/ZFP36/PRDX2/FBXW7/HES1/CEACAM1/H4C8/IHH/TRIB1/LOXL3/N4BP2L2 11 BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 11/689 155/18670 0.02886 0.3439 0.3191 G0S2/PMAIP1/ICAM1/TNFAIP3/PRDX2/ACVR1/CTTN/FAIM/THBS1/MCL1/NOS3 11 BP GO:0007622 rhythmic behavior 5/689 47/18670 0.02887 0.3439 0.3191 EGR2/PTGDS/EGR1/PER3/NR1D1 5 BP GO:0046638 positive regulation of alpha-beta T cell differentiation 5/689 47/18670 0.02887 0.3439 0.3191 NFKBIZ/RIPK2/CD83/IHH/ZAP70 5 BP GO:0042692 muscle cell differentiation 22/689 385/18670 0.02897 0.3439 0.3191 TPM1/TMOD2/MYOM1/ACVR1/RBPMS2/PLEKHO1/H3-3B/SELENON/SMYD1/HES1/MIR26A1/XK/BMP10/CAV2/MSX1/PDLIM5/MTPN/BIN1/MYOF/KLF5/MIR22/DDX39B 22 BP GO:0006914 autophagy 27/689 496/18670 0.02909 0.3439 0.3191 ATP6V0A2/UVRAG/PLK3/NPRL2/PRKAG2/TOMM5/ATP6V0E2/TOMM6/MUL1/CTSK/CTTN/RIPK2/LEPR/CLU/LAMTOR1/PTK2/FBXW7/TBK1/LAMP3/RASIP1/PIM2/MCL1/RUBCN/LEP/STX17/CALCOCO2/ATP6V1G2 27 BP GO:0061919 process utilizing autophagic mechanism 27/689 496/18670 0.02909 0.3439 0.3191 ATP6V0A2/UVRAG/PLK3/NPRL2/PRKAG2/TOMM5/ATP6V0E2/TOMM6/MUL1/CTSK/CTTN/RIPK2/LEPR/CLU/LAMTOR1/PTK2/FBXW7/TBK1/LAMP3/RASIP1/PIM2/MCL1/RUBCN/LEP/STX17/CALCOCO2/ATP6V1G2 27 BP GO:0001975 response to amphetamine 4/689 32/18670 0.02914 0.3439 0.3191 NR4A2/ICAM1/SLC18A2/CNR2 4 BP GO:0042311 vasodilation 4/689 32/18670 0.02914 0.3439 0.3191 GCH1/ADRB3/GUCY1A1/NOS3 4 BP GO:0045987 positive regulation of smooth muscle contraction 4/689 32/18670 0.02914 0.3439 0.3191 PTGS2/ADRA1B/CTTN/SPX 4 BP GO:0060674 placenta blood vessel development 4/689 32/18670 0.02914 0.3439 0.3191 SOCS3/JUNB/PKD2/HES1 4 BP GO:1901661 quinone metabolic process 4/689 32/18670 0.02914 0.3439 0.3191 AKR1C3/PPTC7/COQ4/UBIAD1 4 BP GO:1904467 regulation of tumor necrosis factor secretion 4/689 32/18670 0.02914 0.3439 0.3191 IFIH1/DDX58/ARG2/C1QTNF4 4 BP GO:2000778 positive regulation of interleukin-6 secretion 4/689 32/18670 0.02914 0.3439 0.3191 IFIH1/DDX58/C1QTNF4/AIF1 4 BP GO:0010822 positive regulation of mitochondrion organization 9/689 117/18670 0.02924 0.3439 0.3191 PMAIP1/YWHAH/MUL1/LEPROT/ABLIM3/CHCHD10/FBXW7/RNF31/PDCD5 9 BP GO:0071216 cellular response to biotic stimulus 15/689 236/18670 0.02925 0.3439 0.3191 CXCL8/PDE4B/ICAM1/TNFAIP3/ZFP36/PRDX2/RIPK2/PDCD1LG2/SPON2/CLEC7A/NR1D1/PRKCE/NOS3/TRIB1/SIGIRR 15 BP GO:1904062 regulation of cation transmembrane transport 20/689 342/18670 0.02933 0.344 0.3192 SESTD1/RAMP3/PDE4B/APP/VAMP2/DNAJC30/PKD2/CNIH3/YWHAH/FHL1/PM20D1/CHCHD10/SELENON/MIR26A1/ATP2B4/TLR9/STOM/BIN1/PRKCE/EHD3 20 BP GO:0007568 aging 19/689 321/18670 0.02976 0.3456 0.3206 PTGS2/FOS/AMFR/TPRA1/ICAM1/APP/JUND/POLB/OGG1/ARG2/SERPING1/CCN2/HRAS/LEP/HMGA1/ING2/SIRT3/IL15/MIR22 19 BP GO:0007045 cell-substrate adherens junction assembly 7/689 81/18670 0.02987 0.3456 0.3206 PHLDB2/SLK/TESK2/CTTN/PTK2/THBS1/ROCK2 7 BP GO:0048041 focal adhesion assembly 7/689 81/18670 0.02987 0.3456 0.3206 PHLDB2/SLK/TESK2/CTTN/PTK2/THBS1/ROCK2 7 BP GO:1903533 regulation of protein targeting 7/689 81/18670 0.02987 0.3456 0.3206 LEPROT/ABLIM3/FBXW7/RNF31/PDCD5/HRAS/STOM 7 BP GO:2001021 negative regulation of response to DNA damage stimulus 7/689 81/18670 0.02987 0.3456 0.3206 OGG1/CLU/RNF169/TAF9B/ING2/SMCHD1/DDX39B 7 BP GO:0072527 pyrimidine-containing compound metabolic process 8/689 99/18670 0.02997 0.3456 0.3206 NT5C3A/OGG1/DCTPP1/NME4/GPAM/AGPAT1/NME7/UCK2 8 BP GO:1901570 fatty acid derivative biosynthetic process 8/689 99/18670 0.02997 0.3456 0.3206 PTGS2/PTGDS/ELOVL4/GGTA1P/SCD5/AKR1C3/FAR2/PTGS1 8 BP GO:0007259 JAK-STAT cascade 11/689 156/18670 0.03006 0.3457 0.3208 STAT1/EGF/OSM/SOCS3/STAT2/PKD2/PARP14/LEPROT/HES1/LEP/IL15 11 BP GO:0002685 regulation of leukocyte migration 13/689 196/18670 0.03021 0.3465 0.3215 DUSP1/CXCL8/ICAM1/APP/C5/GCSAM/CCL7/THBS1/P2RY12/SELP/AIF1/CCL28/ZNF580 13 BP GO:0006826 iron ion transport 6/689 64/18670 0.03034 0.3465 0.3215 ATP6V0A2/ATP6V0E2/SLC25A28/SLC39A14/FTL/ATP6V1G2 6 BP GO:0032768 regulation of monooxygenase activity 6/689 64/18670 0.03034 0.3465 0.3215 GCH1/MIR26A1/ATP2B4/CNR2/LEP/NOS3 6 BP GO:0060047 heart contraction 17/689 280/18670 0.0312 0.349 0.3239 TPM1/GCH1/PDE4B/ADRA1B/MIR26A1/ATP2B4/CCN2/SPX/ITPR2/BMP10/RNLS/TMEM65/PDE5A/BIN1/EHD3/NOS3/THRA 17 BP GO:0006488 dolichol-linked oligosaccharide biosynthetic process 3/689 19/18670 0.03121 0.349 0.3239 DOLK/DOLPP1/ALG3 3 BP GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 3/689 19/18670 0.03121 0.349 0.3239 NME4/NME7/UCK2 3 BP GO:0034138 toll-like receptor 3 signaling pathway 3/689 19/18670 0.03121 0.349 0.3239 TNFAIP3/WDFY1/PELI1 3 BP GO:0045414 regulation of interleukin-8 biosynthetic process 3/689 19/18670 0.03121 0.349 0.3239 KLF4/TLR9/CLEC7A 3 BP GO:0072576 liver morphogenesis 3/689 19/18670 0.03121 0.349 0.3239 TNFAIP3/FBXW7/CEACAM1 3 BP GO:0044764 multi-organism cellular process 5/689 48/18670 0.03128 0.349 0.3239 IFIH1/DDX58/RIOK3/GPATCH3/DDX60 5 BP GO:0045933 positive regulation of muscle contraction 5/689 48/18670 0.03128 0.349 0.3239 PTGS2/ADRA1B/CTTN/CCN2/SPX 5 BP GO:0072604 interleukin-6 secretion 5/689 48/18670 0.03128 0.349 0.3239 IFIH1/DDX58/C1QTNF4/LEP/AIF1 5 BP GO:0043271 negative regulation of ion transport 11/689 157/18670 0.03129 0.349 0.3239 PTGS2/SESTD1/ICAM1/PKD2/MIR26A1/THBS1/TLR9/LEP/BIN1/PRKCE/NOS3 11 BP GO:0032103 positive regulation of response to external stimulus 19/689 323/18670 0.03142 0.3495 0.3243 PTGS2/CXCL8/OSM/NFKBIZ/GBP5/PLG/RIPK2/CCL7/TBK1/THBS1/P2RY12/TLR9/CLEC7A/C2CD4A/AIF1/IL15/MIR22/DDX60/ZNF580 19 BP GO:0001959 regulation of cytokine-mediated signaling pathway 12/689 177/18670 0.03148 0.3495 0.3243 STAT1/SOCS3/TNFAIP3/MUL1/PARP14/RIPK2/TBK1/MIR26A1/RNF31/C1QTNF4/AGPAT1/SIGIRR 12 BP GO:0060840 artery development 8/689 100/18670 0.03157 0.3497 0.3244 PKD2/HES1/SNX17/MYLK/LEP/TAB1/DCTN5/HOXA1 8 BP GO:0055117 regulation of cardiac muscle contraction 7/689 82/18670 0.03166 0.3497 0.3245 PDE4B/ADRA1B/CCN2/BMP10/PDE5A/BIN1/EHD3 7 BP GO:0002791 regulation of peptide secretion 27/689 500/18670 0.03172 0.3497 0.3245 GBP1/SLC2A1/OSM/BMP8A/TNFAIP3/MYOM1/IFIH1/DDX58/GLUL/RIPK2/ARG2/PANX1/PHPT1/C5/RHBDF2/CDK16/TLR9/C1QTNF4/ITPR2/LEP/SYTL4/NR1D1/AIF1/SIRT3/PRKCE/TNFRSF4/BTN2A2 27 BP GO:0033002 muscle cell proliferation 15/689 239/18670 0.0322 0.3537 0.3282 PTGS2/TPM1/STAT1/ADAMTS1/TNFAIP3/RBPMS2/KLF4/MIR26A1/THBS1/BMP10/AIF1/TRIB1/IL15/SAV1/DDX39B 15 BP GO:0051443 positive regulation of ubiquitin-protein transferase activity 4/689 33/18670 0.03222 0.3537 0.3282 CDC14B/FBXW7/MASTL/PLK1 4 BP GO:0060389 pathway-restricted SMAD protein phosphorylation 6/689 65/18670 0.03242 0.355 0.3294 BMP8A/ACVR1/GDF9/BMP8B/BMP10/TWSG1 6 BP GO:0022406 membrane docking 12/689 178/18670 0.03267 0.3566 0.3309 ICAM1/TCTN2/VTI1B/SCLT1/MOSPD3/CNTRL/STX17/CAV2/IQCB1/TTBK2/RAB11A/PLK1 12 BP GO:0030198 extracellular matrix organization 21/689 368/18670 0.03272 0.3566 0.3309 PHLDB2/ICAM1/APP/FBLN2/FSCN1/CAPNS2/CTSK/PLG/PLOD2/PTK2/ICAM4/THBS1/CCN2/POMT1/ITGB5/ADAMTSL4/SPINT2/ITGB3/IHH/MATN1/LOXL3 21 BP GO:0031532 actin cytoskeleton reorganization 8/689 101/18670 0.03322 0.3574 0.3317 RHOBTB1/CTTN/AUTS2/PHPT1/SIPA1L1/HRAS/DTNBP1/RHOBTB2 8 BP GO:0032611 interleukin-1 beta production 8/689 101/18670 0.03322 0.3574 0.3317 APP/GBP5/EGR1/TNFAIP3/RIPK2/ARG2/PANX1/CLEC7A 8 BP GO:0046632 alpha-beta T cell differentiation 8/689 101/18670 0.03322 0.3574 0.3317 NFKBIZ/IRF1/RIPK2/CD83/IHH/ZAP70/LOXL3/BATF 8 BP GO:0048661 positive regulation of smooth muscle cell proliferation 8/689 101/18670 0.03322 0.3574 0.3317 PTGS2/STAT1/ADAMTS1/RBPMS2/MIR26A1/THBS1/AIF1/DDX39B 8 BP GO:0050830 defense response to Gram-positive bacterium 8/689 101/18670 0.03322 0.3574 0.3317 GBP2/GBP7/LCE3B/GBP4/RIPK2/TBK1/SPACA5/SPACA5B 8 BP GO:0051091 positive regulation of DNA-binding transcription factor activity 16/689 261/18670 0.03324 0.3574 0.3317 ICAM1/APP/TRIM26/DDX58/RIPK2/CLU/LRRFIP1/OPRD1/RNF31/TLR9/ROR1/MTPN/TAB1/TRAPPC9/TRIM38/SAV1 16 BP GO:1901987 regulation of cell cycle phase transition 26/689 480/18670 0.03348 0.3575 0.3317 DUSP1/TPRA1/BTG2/NBN/APP/ADAMTS1/PLK3/PLAGL1/PKD2/MOS/FHL1/CDC14B/KLF4/FBXW7/CNTRL/CTDSPL/MIR26A1/ATP2B4/RNASEH2B/TAOK1/AIF1/RAB11A/PLK1/PBX1/ANAPC1/BTN2A2 26 BP GO:0045582 positive regulation of T cell differentiation 7/689 83/18670 0.03352 0.3575 0.3317 EGR3/NFKBIZ/RIPK2/CD83/IHH/ZAP70/BTN2A2 7 BP GO:0071277 cellular response to calcium ion 7/689 83/18670 0.03352 0.3575 0.3317 FOS/JUNB/PKD2/JUND/AKR1C3/CLIC4/FOSB 7 BP GO:0035690 cellular response to drug 21/689 369/18670 0.03355 0.3575 0.3317 PTGS2/XRN1/PDE4B/ICAM1/GUCY1B1/EGR1/TNFAIP3/RIPK2/KLF4/CCL7/CASTOR1/ATP2B4/P2RY12/ROCK2/ITPR2/MSX1/AIF1/PRKCE/CHRM5/SETX/ZNF580 21 BP GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 5/689 49/18670 0.03382 0.3596 0.3337 STAT1/TNFAIP3/RIOK3/TLE1/NR1D1 5 BP GO:0051258 protein polymerization 17/689 283/18670 0.03402 0.361 0.3349 TMOD2/PSTPIP2/ARL6/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/WASF3/RHOBTB2/AIF1/BIN1/PRKCE 17 BP GO:0032660 regulation of interleukin-17 production 4/689 34/18670 0.03549 0.3623 0.3362 OSM/ARG2/MIR26A1/IL15 4 BP GO:0034205 amyloid-beta formation 4/689 34/18670 0.03549 0.3623 0.3362 APP/CLU/ROCK2/BIN1 4 BP GO:0043094 cellular metabolic compound salvage 4/689 34/18670 0.03549 0.3623 0.3362 GMPR/PRTFDC1/APRT/UCK2 4 BP GO:0070884 regulation of calcineurin-NFAT signaling cascade 4/689 34/18670 0.03549 0.3623 0.3362 ATP2B4/SPPL3/LMCD1/CAMTA1 4 BP GO:0071875 adrenergic receptor signaling pathway 4/689 34/18670 0.03549 0.3623 0.3362 ADRA1B/ATP2B4/ADRB3/OR56A1 4 BP GO:0097009 energy homeostasis 4/689 34/18670 0.03549 0.3623 0.3362 BMP8A/METRNL/LEPR/PM20D1 4 BP GO:0106056 regulation of calcineurin-mediated signaling 4/689 34/18670 0.03549 0.3623 0.3362 ATP2B4/SPPL3/LMCD1/CAMTA1 4 BP GO:0006071 glycerol metabolic process 3/689 20/18670 0.03574 0.3623 0.3362 GPD2/LEP/MYOF 3 BP GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 3/689 20/18670 0.03574 0.3623 0.3362 DOLK/DOLPP1/ALG3 3 BP GO:0006525 arginine metabolic process 3/689 20/18670 0.03574 0.3623 0.3362 ARG2/ATP2B4/NOS3 3 BP GO:0010592 positive regulation of lamellipodium assembly 3/689 20/18670 0.03574 0.3623 0.3362 FSCN1/AUTS2/NCKAP1 3 BP GO:0030903 notochord development 3/689 20/18670 0.03574 0.3623 0.3362 ID3/NOTO/KDM6A 3 BP GO:0032769 negative regulation of monooxygenase activity 3/689 20/18670 0.03574 0.3623 0.3362 MIR26A1/ATP2B4/CNR2 3 BP GO:0039529 RIG-I signaling pathway 3/689 20/18670 0.03574 0.3623 0.3362 DDX58/GPATCH3/DDX60 3 BP GO:0042228 interleukin-8 biosynthetic process 3/689 20/18670 0.03574 0.3623 0.3362 KLF4/TLR9/CLEC7A 3 BP GO:0042535 positive regulation of tumor necrosis factor biosynthetic process 3/689 20/18670 0.03574 0.3623 0.3362 APP/THBS1/CLEC7A 3 BP GO:0048745 smooth muscle tissue development 3/689 20/18670 0.03574 0.3623 0.3362 PKD2/MYLK/IHH 3 BP GO:0070828 heterochromatin organization 3/689 20/18670 0.03574 0.3623 0.3362 H3-3B/HMGA1/SMCHD1 3 BP GO:0072234 metanephric nephron tubule development 3/689 20/18670 0.03574 0.3623 0.3362 STAT1/PKD2/HES1 3 BP GO:1902993 positive regulation of amyloid precursor protein catabolic process 3/689 20/18670 0.03574 0.3623 0.3362 APP/CLU/ROCK2 3 BP GO:2000774 positive regulation of cellular senescence 3/689 20/18670 0.03574 0.3623 0.3362 ARG2/HMGA1/MIR22 3 BP GO:0010959 regulation of metal ion transport 22/689 394/18670 0.03605 0.3647 0.3384 PTGS2/SESTD1/RAMP3/EGF/PDE4B/ICAM1/VAMP2/PKD2/YWHAH/FHL1/SELENON/OPRD1/MIR26A1/ATP2B4/MYLK/P2RY12/TLR9/STOM/BIN1/PRKCE/EHD3/NOS3 22 BP GO:0019932 second-messenger-mediated signaling 24/689 439/18670 0.03644 0.3667 0.3402 PDE3A/RAMP3/GBP1/ADGRE5/CXCL8/PKD2/GUCY1B1/ADRA1B/SELENON/ATP2B4/THBS1/P2RY12/GNA13/SPPL3/LMCD1/ITPR2/ADRB3/SELP/GUCY1A1/PDE5A/CAMTA1/NOS3/ZAP70/OR56A1 24 BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 5/689 50/18670 0.03648 0.3667 0.3402 PARP14/RIPK2/TBK1/C1QTNF4/AGPAT1 5 BP GO:0070741 response to interleukin-6 5/689 50/18670 0.03648 0.3667 0.3402 STAT1/ICAM1/SOCS3/MIR26A1/C1QTNF4 5 BP GO:0032652 regulation of interleukin-1 production 8/689 103/18670 0.03671 0.3675 0.341 APP/EGR1/TNFAIP3/RIPK2/ARG2/PANX1/CEACAM1/CLEC7A 8 BP GO:0032984 protein-containing complex disassembly 19/689 329/18670 0.03682 0.3675 0.341 TMOD2/UVRAG/NAPA/MAP1A/GADD45GIP1/CHCHD10/MRPL4/MRPS2/RUBCN/HMGA1/STX17/TAOK1/MRPL46/VIL1/MTPN/CALCOCO2/TTBK2/SETX/H2AW 19 BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 9/689 122/18670 0.03683 0.3675 0.341 NUB1/PLK3/MAP1A/CLU/ZFAND2A/RAD23A/RNF19B/PLK1/TRIB1 9 BP GO:0048662 negative regulation of smooth muscle cell proliferation 6/689 67/18670 0.03686 0.3675 0.341 TPM1/TNFAIP3/KLF4/AIF1/TRIB1/IL15 6 BP GO:0010631 epithelial cell migration 20/689 351/18670 0.03698 0.3679 0.3414 PTGS2/EGR3/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/VIL1/PRKCE/ITGB3/RAB11A/NOS3/PLEKHG5/MIR22/ZNF580 20 BP GO:1902806 regulation of cell cycle G1/S phase transition 13/689 202/18670 0.03718 0.3691 0.3425 BTG2/ADAMTS1/PLK3/PLAGL1/PKD2/FHL1/KLF4/FBXW7/CTDSPL/MIR26A1/ATP2B4/AIF1/BTN2A2 13 BP GO:0045444 fat cell differentiation 14/689 223/18670 0.03754 0.3719 0.3451 PTGS2/EGR2/NR4A2/ARL6/METRNL/ZFP36/GLIS1/KLF4/HES1/LEP/NR1D1/SDF4/KLF5/SAV1 14 BP GO:0010821 regulation of mitochondrion organization 12/689 182/18670 0.03777 0.3734 0.3465 PMAIP1/STAT2/YWHAH/MUL1/CTTN/LEPROT/ABLIM3/CLU/CHCHD10/FBXW7/RNF31/PDCD5 12 BP GO:0008202 steroid metabolic process 19/689 331/18670 0.03877 0.3786 0.3513 APP/APOL1/PRKAG2/EGR1/YWHAH/MVK/CYP7B1/LEPR/AKR1C3/LAMTOR1/GPAM/SNX17/FAXDC2/DHRS11/SMPD1/UGT2B7/LEP/NR1D1/PBX1 19 BP GO:0032735 positive regulation of interleukin-12 production 4/689 35/18670 0.03894 0.3786 0.3513 IRF1/RIPK2/TLR9/CLEC7A 4 BP GO:1902991 regulation of amyloid precursor protein catabolic process 4/689 35/18670 0.03894 0.3786 0.3513 APP/CLU/ROCK2/BIN1 4 BP GO:1990774 tumor necrosis factor secretion 4/689 35/18670 0.03894 0.3786 0.3513 IFIH1/DDX58/ARG2/C1QTNF4 4 BP GO:0061136 regulation of proteasomal protein catabolic process 12/689 183/18670 0.03913 0.3786 0.3513 NUB1/PLK3/MAP1A/CLU/ZFAND2A/RAD23A/FBXW7/LAMP3/USP25/RNF19B/PLK1/TRIB1 12 BP GO:0035914 skeletal muscle cell differentiation 6/689 68/18670 0.03922 0.3786 0.3513 EGR2/FOS/BTG2/EGR1/SMYD1/KLF5 6 BP GO:0009994 oocyte differentiation 5/689 51/18670 0.03926 0.3786 0.3513 PDE3A/GDF9/DMC1/REC8/PDE5A 5 BP GO:0019369 arachidonic acid metabolic process 5/689 51/18670 0.03926 0.3786 0.3513 PTGS2/PTGDS/MGLL/AKR1C3/PTGS1 5 BP GO:0021545 cranial nerve development 5/689 51/18670 0.03926 0.3786 0.3513 EGR2/ATOH7/HOXB3/HES1/HOXA1 5 BP GO:0097366 response to bronchodilator 5/689 51/18670 0.03926 0.3786 0.3513 NR4A2/ICAM1/SLC18A2/GUCY1B1/CNR2 5 BP GO:0035296 regulation of tube diameter 10/689 143/18670 0.03932 0.3786 0.3513 PTGS2/GCH1/ICAM1/ADRA1B/ROCK2/UTS2B/ADRB3/LEP/GUCY1A1/NOS3 10 BP GO:0050880 regulation of blood vessel size 10/689 143/18670 0.03932 0.3786 0.3513 PTGS2/GCH1/ICAM1/ADRA1B/ROCK2/UTS2B/ADRB3/LEP/GUCY1A1/NOS3 10 BP GO:0097746 regulation of blood vessel diameter 10/689 143/18670 0.03932 0.3786 0.3513 PTGS2/GCH1/ICAM1/ADRA1B/ROCK2/UTS2B/ADRB3/LEP/GUCY1A1/NOS3 10 BP GO:0090559 regulation of membrane permeability 7/689 86/18670 0.03954 0.3799 0.3525 PMAIP1/YWHAH/MUL1/CHCHD10/TJP2/RASIP1/LAPTM4B 7 BP GO:1901988 negative regulation of cell cycle phase transition 16/689 267/18670 0.03961 0.3799 0.3525 DUSP1/TPRA1/BTG2/NBN/PLK3/PLAGL1/PKD2/MOS/FHL1/CDC14B/KLF4/CTDSPL/MIR26A1/TAOK1/PLK1/BTN2A2 16 BP GO:0090132 epithelium migration 20/689 354/18670 0.03983 0.38 0.3526 PTGS2/EGR3/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/VIL1/PRKCE/ITGB3/RAB11A/NOS3/PLEKHG5/MIR22/ZNF580 20 BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 8/689 105/18670 0.04043 0.38 0.3526 PTGS2/RAMP3/OSM/APP/RIPK2/TBK1/OPRD1/ATP2B4 8 BP GO:0036499 PERK-mediated unfolded protein response 3/689 21/18670 0.04059 0.38 0.3526 PPP1R15A/CXCL8/NCK2 3 BP GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 3/689 21/18670 0.04059 0.38 0.3526 RIOK3/GPATCH3/DDX60 3 BP GO:0042749 regulation of circadian sleep/wake cycle 3/689 21/18670 0.04059 0.38 0.3526 PTGDS/PER3/NR1D1 3 BP GO:0046132 pyrimidine ribonucleoside biosynthetic process 3/689 21/18670 0.04059 0.38 0.3526 NME4/NME7/UCK2 3 BP GO:0051383 kinetochore organization 3/689 21/18670 0.04059 0.38 0.3526 RNF4/CENPC/CENPS 3 BP GO:0071498 cellular response to fluid shear stress 3/689 21/18670 0.04059 0.38 0.3526 PTGS2/PKD2/KLF4 3 BP GO:1900273 positive regulation of long-term synaptic potentiation 3/689 21/18670 0.04059 0.38 0.3526 APP/NRGN/STAU1 3 BP GO:1902884 positive regulation of response to oxidative stress 3/689 21/18670 0.04059 0.38 0.3526 FBXW7/SELENON/MCL1 3 BP GO:1904469 positive regulation of tumor necrosis factor secretion 3/689 21/18670 0.04059 0.38 0.3526 IFIH1/DDX58/C1QTNF4 3 BP GO:2000678 negative regulation of transcription regulatory region DNA binding 3/689 21/18670 0.04059 0.38 0.3526 FBXW7/ZNF593/MSX1 3 BP GO:0035150 regulation of tube size 10/689 144/18670 0.04093 0.3825 0.3549 PTGS2/GCH1/ICAM1/ADRA1B/ROCK2/UTS2B/ADRB3/LEP/GUCY1A1/NOS3 10 BP GO:0034404 nucleobase-containing small molecule biosynthetic process 14/689 226/18670 0.04124 0.3847 0.3569 PDE4B/APP/PRKAG2/NUP188/OGG1/DCTPP1/NME4/PRTFDC1/PGK1/APRT/ADPGK/PDE5A/NME7/UCK2 14 BP GO:0042698 ovulation cycle 6/689 69/18670 0.04168 0.3866 0.3587 ADAMTS1/EGR1/GDF9/LEP/NRIP1/NOS3 6 BP GO:0051865 protein autoubiquitination 6/689 69/18670 0.04168 0.3866 0.3587 RNF11/AMFR/RNF4/TRIM68/RNF19B/RNF213 6 BP GO:0048477 oogenesis 7/689 87/18670 0.04169 0.3866 0.3587 PDE3A/H3-3B/GDF9/DMC1/REC8/PDE5A/IHH 7 BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 9/689 125/18670 0.04199 0.3886 0.3606 BTG2/PLK3/PLAGL1/PKD2/FHL1/KLF4/CTDSPL/MIR26A1/BTN2A2 9 BP GO:0031529 ruffle organization 5/689 52/18670 0.04217 0.3888 0.3608 TPM1/ICAM1/P2RY12/HRAS/AIF1 5 BP GO:0032731 positive regulation of interleukin-1 beta production 5/689 52/18670 0.04217 0.3888 0.3608 APP/EGR1/RIPK2/PANX1/CLEC7A 5 BP GO:0000077 DNA damage checkpoint 10/689 145/18670 0.04258 0.391 0.3628 BTG2/NBN/PLK3/PLAGL1/CDC14B/MDC1/RNASEH2B/TAOK1/PLK1/DDX39B 10 BP GO:0010453 regulation of cell fate commitment 4/689 36/18670 0.04258 0.391 0.3628 NKX6-2/GLIS1/HES1/LOXL3 4 BP GO:0072522 purine-containing compound biosynthetic process 18/689 313/18670 0.04276 0.392 0.3637 PPCDC/ELOVL4/GMPR/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/PRTFDC1/PGK1/APRT/ADPGK/GUCY1A1/NME7/NOS3/AK9 18 BP GO:0022412 cellular process involved in reproduction in multicellular organism 20/689 357/18670 0.04284 0.392 0.3637 PDE3A/DND1/PRMT7/TDRKH/ACVR1/H3-3B/GDF9/TTLL1/DMC1/CATSPER3/REC8/TSSK6/TPGS1/MASTL/PDE5A/ING2/BOLL/ETV6/IHH/PLK1 20 BP GO:0055001 muscle cell development 12/689 186/18670 0.04341 0.3964 0.3678 TPM1/TMOD2/MYOM1/SELENON/HES1/XK/BMP10/CAV2/PDLIM5/BIN1/MYOF/DDX39B 12 BP GO:0051321 meiotic cell cycle 15/689 249/18670 0.04359 0.3973 0.3686 DUSP1/PDE3A/NBN/MOS/TDRKH/CENPC/CENPS/DMC1/REC8/MSX1/RAD54B/MASTL/ING2/BOLL/PLK1 15 BP GO:0002696 positive regulation of leukocyte activation 21/689 380/18670 0.04367 0.3973 0.3686 EGR3/NFKBIZ/SIRPB1/RIPK2/NCK2/PELI1/HES1/PDCD1LG2/THBS1/TLR9/MPL/CLEC7A/LEP/CD83/ATP11C/AIF1/IHH/ZAP70/IL15/TNFRSF4/BTN2A2 21 BP GO:0034103 regulation of tissue remodeling 7/689 88/18670 0.04391 0.3985 0.3698 TNFAIP3/LEPR/CEACAM1/ROCK2/LEP/ITGB3/IL15 7 BP GO:0016125 sterol metabolic process 11/689 166/18670 0.04407 0.3985 0.3698 APP/APOL1/PRKAG2/MVK/CYP7B1/LEPR/GPAM/SNX17/FAXDC2/SMPD1/LEP 11 BP GO:0097696 STAT cascade 11/689 166/18670 0.04407 0.3985 0.3698 STAT1/EGF/OSM/SOCS3/STAT2/PKD2/PARP14/LEPROT/HES1/LEP/IL15 11 BP GO:0034121 regulation of toll-like receptor signaling pathway 6/689 70/18670 0.04422 0.3985 0.3698 IRF1/TNFAIP3/WDFY1/PELI1/TLR9/NR1D1 6 BP GO:0060395 SMAD protein signal transduction 6/689 70/18670 0.04422 0.3985 0.3698 FOS/VEPH1/BMP8A/GDF9/BMP8B/BMP10 6 BP GO:0048524 positive regulation of viral process 8/689 107/18670 0.04439 0.3985 0.3698 GTF2F2/ZNF502/RAD23A/STAU1/CAV2/PABPC1/STOM/TRIM38 8 BP GO:0050905 neuromuscular process 8/689 107/18670 0.04439 0.3985 0.3698 GCH1/NBN/APP/NKX6-2/CAMTA1/HOXA1/RBFOX2/CDH23 8 BP GO:1905475 regulation of protein localization to membrane 12/689 187/18670 0.0449 0.4016 0.3727 PMAIP1/RAMP3/GBP1/YWHAH/VTI1B/PDCD5/HRAS/CNPY4/VIL1/STOM/PRKCE/RAB11A 12 BP GO:0050702 interleukin-1 beta secretion 5/689 53/18670 0.04521 0.4016 0.3727 GBP5/TNFAIP3/RIPK2/ARG2/PANX1 5 BP GO:0048285 organelle fission 24/689 449/18670 0.04526 0.4016 0.3727 DUSP1/PDE3A/EGF/STAT2/KLHDC8B/MOS/MUL1/TDRKH/CENPC/CDC14B/RCC1/CENPS/DMC1/HASPIN/REC8/CAV2/MSX1/RAD54B/MASTL/ING2/PPP2R2D/RAB11A/PLK1/ANAPC1 24 BP GO:0035270 endocrine system development 9/689 127/18670 0.04568 0.4016 0.3727 NKX6-2/GSX1/PITX1/ONECUT2/HOXB3/HES1/MSX1/THRA/PBX1 9 BP GO:0006379 mRNA cleavage 3/689 22/18670 0.04574 0.4016 0.3727 PCF11/AGO2/MOV10 3 BP GO:0009220 pyrimidine ribonucleotide biosynthetic process 3/689 22/18670 0.04574 0.4016 0.3727 NME4/NME7/UCK2 3 BP GO:0010155 regulation of proton transport 3/689 22/18670 0.04574 0.4016 0.3727 DNAJC30/PM20D1/CHCHD10 3 BP GO:0022010 central nervous system myelination 3/689 22/18670 0.04574 0.4016 0.3727 NKX6-2/CLU/MIR26A1 3 BP GO:0032291 axon ensheathment in central nervous system 3/689 22/18670 0.04574 0.4016 0.3727 NKX6-2/CLU/MIR26A1 3 BP GO:0033622 integrin activation 3/689 22/18670 0.04574 0.4016 0.3727 RASIP1/P2RY12/SELP 3 BP GO:0044321 response to leptin 3/689 22/18670 0.04574 0.4016 0.3727 LEPR/LEP/NR1D1 3 BP GO:1904666 regulation of ubiquitin protein ligase activity 3/689 22/18670 0.04574 0.4016 0.3727 CDC14B/MASTL/PLK1 3 BP GO:0090130 tissue migration 20/689 360/18670 0.04601 0.4018 0.3728 PTGS2/EGR3/GLUL/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/ROCK2/BMP10/MIR129-1/VIL1/PRKCE/ITGB3/RAB11A/NOS3/PLEKHG5/MIR22/ZNF580 20 BP GO:0097306 cellular response to alcohol 7/689 89/18670 0.04622 0.4018 0.3728 GRAMD1B/XRN1/AKR1C3/KLF4/CCL7/ITPR2/PRKCE 7 BP GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 4/689 37/18670 0.0464 0.4018 0.3728 BTG2/ZFP36/AGO2/PABPC1 4 BP GO:0034405 response to fluid shear stress 4/689 37/18670 0.0464 0.4018 0.3728 PTGS2/PKD2/KLF4/NOS3 4 BP GO:0043114 regulation of vascular permeability 4/689 37/18670 0.0464 0.4018 0.3728 PDE3A/FGFBP3/CEACAM1/C2CD4A 4 BP GO:0043243 positive regulation of protein complex disassembly 4/689 37/18670 0.0464 0.4018 0.3728 UVRAG/VIL1/CALCOCO2/SETX 4 BP GO:0071276 cellular response to cadmium ion 4/689 37/18670 0.0464 0.4018 0.3728 FOS/MT1G/OGG1/AKR1C3 4 BP GO:1903046 meiotic cell cycle process 12/689 188/18670 0.04643 0.4018 0.3728 PDE3A/MOS/TDRKH/CENPC/CENPS/DMC1/REC8/MSX1/RAD54B/MASTL/ING2/PLK1 12 BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 6/689 71/18670 0.04686 0.4042 0.375 OSM/SOCS3/PARP14/HES1/LEP/IL15 6 BP GO:0010948 negative regulation of cell cycle process 20/689 361/18670 0.04711 0.4042 0.375 DUSP1/TPRA1/BTG2/NBN/PLK3/PLAGL1/PKD2/MOS/MAX/FHL1/CDC14B/KLF4/FBXW7/CTDSPL/MIR26A1/HMGN5/MDM1/TAOK1/PLK1/BTN2A2 20 BP GO:0071496 cellular response to external stimulus 19/689 339/18670 0.0473 0.4042 0.375 PTGS2/PMAIP1/NR4A2/FOS/SLC2A1/ICAM1/IRF1/NPRL2/DCTPP1/MAX/KLF10/GLUL/AKR1C3/CASTOR1/P2RY12/LEP/MTPN/AIF1/IL15 19 BP GO:0002687 positive regulation of leukocyte migration 9/689 128/18670 0.0476 0.4042 0.375 CXCL8/ICAM1/APP/CCL7/THBS1/P2RY12/SELP/AIF1/ZNF580 9 BP GO:0051592 response to calcium ion 10/689 148/18670 0.04779 0.4042 0.375 DUSP1/FOS/JUNB/PKD2/JUND/AKR1C3/CLIC4/FOSB/THBS1/TSHB 10 BP GO:0009612 response to mechanical stimulus 13/689 210/18670 0.04818 0.4042 0.375 PTGS2/FOS/STAT1/BTG2/SLC2A1/JUNB/IRF1/PKD2/JUND/FOSB/THBS1/MTPN/IHH 13 BP GO:0032655 regulation of interleukin-12 production 5/689 54/18670 0.04837 0.4042 0.375 IRF1/RIPK2/THBS1/TLR9/CLEC7A 5 BP GO:0000280 nuclear division 22/689 407/18670 0.04844 0.4042 0.375 DUSP1/PDE3A/EGF/KLHDC8B/MOS/TDRKH/CENPC/CDC14B/RCC1/CENPS/DMC1/HASPIN/REC8/CAV2/MSX1/RAD54B/MASTL/ING2/PPP2R2D/RAB11A/PLK1/ANAPC1 22 BP GO:0030901 midbrain development 7/689 90/18670 0.04859 0.4042 0.375 NR4A2/YWHAH/GNB4/HES1/MSX1/OTX1/BARHL1 7 BP GO:0032651 regulation of interleukin-1 beta production 7/689 90/18670 0.04859 0.4042 0.375 APP/EGR1/TNFAIP3/RIPK2/ARG2/PANX1/CLEC7A 7 BP GO:0034333 adherens junction assembly 7/689 90/18670 0.04859 0.4042 0.375 PHLDB2/SLK/TESK2/CTTN/PTK2/THBS1/ROCK2 7 BP GO:0048545 response to steroid hormone 21/689 385/18670 0.04895 0.4042 0.375 PTGS2/DUSP1/NR4A2/FOS/RNF4/ICAM1/YWHAH/ZFP36/CYP7B1/AKR1C3/FOSB/GPAM/THBS1/CCN2/CATSPER3/TRIM68/NRIP1/NR1D1/AIF1/THRA/RBFOX2 21 BP GO:0140056 organelle localization by membrane tethering 11/689 169/18670 0.04902 0.4042 0.375 TCTN2/VTI1B/SCLT1/MOSPD3/CNTRL/STX17/CAV2/IQCB1/TTBK2/RAB11A/PLK1 11 BP GO:0060537 muscle tissue development 22/689 408/18670 0.04951 0.4042 0.375 TPM1/EGR2/FOS/BTG2/PKD2/EGR1/MYOM1/PITX1/ACVR1/SELENON/SMYD1/HOXD9/XK/MYLK/BMP10/CAV2/PDLIM5/MTPN/IHH/KLF5/SAV1/DDX39B 22 BP GO:0009165 nucleotide biosynthetic process 21/689 386/18670 0.05005 0.4042 0.375 PTGS2/PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/GPAM/PGK1/APRT/ADPGK/RNLS/AGPAT1/GUCY1A1/NME7/NOS3/AK9/UCK2 21 BP GO:0006228 UTP biosynthetic process 2/689 10/18670 0.05028 0.4042 0.375 NME4/NME7 2 BP GO:0006285 base-excision repair, AP site formation 2/689 10/18670 0.05028 0.4042 0.375 MUTYH/OGG1 2 BP GO:0006930 substrate-dependent cell migration, cell extension 2/689 10/18670 0.05028 0.4042 0.375 CTTN/P2RY12 2 BP GO:0032463 negative regulation of protein homooligomerization 2/689 10/18670 0.05028 0.4042 0.375 RIOK3/CLU 2 BP GO:0032621 interleukin-18 production 2/689 10/18670 0.05028 0.4042 0.375 GBP5/TLR9 2 BP GO:0033210 leptin-mediated signaling pathway 2/689 10/18670 0.05028 0.4042 0.375 LEPR/LEP 2 BP GO:0035871 protein K11-linked deubiquitination 2/689 10/18670 0.05028 0.4042 0.375 TNFAIP3/VCPIP1 2 BP GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 2/689 10/18670 0.05028 0.4042 0.375 EGF/FBXW7 2 BP GO:0045988 negative regulation of striated muscle contraction 2/689 10/18670 0.05028 0.4042 0.375 PDE5A/BIN1 2 BP GO:0046642 negative regulation of alpha-beta T cell proliferation 2/689 10/18670 0.05028 0.4042 0.375 ARG2/TWSG1 2 BP GO:0051918 negative regulation of fibrinolysis 2/689 10/18670 0.05028 0.4042 0.375 PLG/THBS1 2 BP GO:0052646 alditol phosphate metabolic process 2/689 10/18670 0.05028 0.4042 0.375 GPD2/GPAM 2 BP GO:0060281 regulation of oocyte development 2/689 10/18670 0.05028 0.4042 0.375 PDE3A/PDE5A 2 BP GO:0071609 chemokine (C-C motif) ligand 5 production 2/689 10/18670 0.05028 0.4042 0.375 MUL1/ARG2 2 BP GO:0072203 cell proliferation involved in metanephros development 2/689 10/18670 0.05028 0.4042 0.375 STAT1/EGR1 2 BP GO:0072641 type I interferon secretion 2/689 10/18670 0.05028 0.4042 0.375 IFIH1/DDX58 2 BP GO:0090336 positive regulation of brown fat cell differentiation 2/689 10/18670 0.05028 0.4042 0.375 PTGS2/METRNL 2 BP GO:0090557 establishment of endothelial intestinal barrier 2/689 10/18670 0.05028 0.4042 0.375 ICAM1/TJP2 2 BP GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/689 10/18670 0.05028 0.4042 0.375 PMAIP1/NCK2 2 BP GO:1903897 regulation of PERK-mediated unfolded protein response 2/689 10/18670 0.05028 0.4042 0.375 PPP1R15A/NCK2 2 BP GO:1905879 regulation of oogenesis 2/689 10/18670 0.05028 0.4042 0.375 PDE3A/PDE5A 2 BP GO:1990535 neuron projection maintenance 2/689 10/18670 0.05028 0.4042 0.375 APP/MAP1A 2 BP GO:0032620 interleukin-17 production 4/689 38/18670 0.0504 0.4042 0.375 OSM/ARG2/MIR26A1/IL15 4 BP GO:0046636 negative regulation of alpha-beta T cell activation 4/689 38/18670 0.0504 0.4042 0.375 ARG2/TWSG1/IHH/LOXL3 4 BP GO:0071867 response to monoamine 4/689 38/18670 0.0504 0.4042 0.375 PDE4B/APP/ATP2B4/RNLS 4 BP GO:0071869 response to catecholamine 4/689 38/18670 0.0504 0.4042 0.375 PDE4B/APP/ATP2B4/RNLS 4 BP GO:0097352 autophagosome maturation 4/689 38/18670 0.0504 0.4042 0.375 UVRAG/RUBCN/STX17/CALCOCO2 4 BP GO:0006939 smooth muscle contraction 8/689 110/18670 0.0508 0.4042 0.375 PTGS2/ADRA1B/CTTN/ATP2B4/MYLK/ROCK2/SPX/GUCY1A1 8 BP GO:0097305 response to alcohol 14/689 233/18670 0.05088 0.4042 0.375 GRAMD1B/FOS/XRN1/ICAM1/POLB/OGG1/AKR1C3/KLF4/CCL7/FOSB/ITPR2/LEP/PRKCE/SDF4 14 BP GO:0009310 amine catabolic process 3/689 23/18670 0.05121 0.4042 0.375 SAT1/ATP2B4/SMOX 3 BP GO:0019400 alditol metabolic process 3/689 23/18670 0.05121 0.4042 0.375 GPD2/LEP/MYOF 3 BP GO:0032703 negative regulation of interleukin-2 production 3/689 23/18670 0.05121 0.4042 0.375 GBP1/TNFAIP3/ZFP36 3 BP GO:0034123 positive regulation of toll-like receptor signaling pathway 3/689 23/18670 0.05121 0.4042 0.375 WDFY1/PELI1/TLR9 3 BP GO:0042401 cellular biogenic amine biosynthetic process 3/689 23/18670 0.05121 0.4042 0.375 SAT1/ODC1/SMOX 3 BP GO:0072170 metanephric tubule development 3/689 23/18670 0.05121 0.4042 0.375 STAT1/PKD2/HES1 3 BP GO:0072243 metanephric nephron epithelium development 3/689 23/18670 0.05121 0.4042 0.375 STAT1/PKD2/HES1 3 BP GO:0090343 positive regulation of cell aging 3/689 23/18670 0.05121 0.4042 0.375 ARG2/HMGA1/MIR22 3 BP GO:1901889 negative regulation of cell junction assembly 3/689 23/18670 0.05121 0.4042 0.375 PHLDB2/THBS1/ROCK2 3 BP GO:0008360 regulation of cell shape 10/689 150/18670 0.05149 0.4042 0.375 TPM1/ICAM1/ARHGAP18/PLEKHO1/PTK2/CCL7/GNA13/PRPF40A/VIL1/WASF3 10 BP GO:0043551 regulation of phosphatidylinositol 3-kinase activity 5/689 55/18670 0.05167 0.4042 0.375 SOCS3/KLF4/PTK2/P2RY12/RUBCN 5 BP GO:0046456 icosanoid biosynthetic process 5/689 55/18670 0.05167 0.4042 0.375 PTGS2/PTGDS/GGTA1P/AKR1C3/PTGS1 5 BP GO:0048016 inositol phosphate-mediated signaling 5/689 55/18670 0.05167 0.4042 0.375 ATP2B4/SPPL3/LMCD1/ITPR2/CAMTA1 5 BP GO:0007517 muscle organ development 22/689 410/18670 0.05169 0.4042 0.375 TPM1/EGR3/EGR2/FOS/BTG2/EGR1/MYOM1/PITX1/FHL1/ID3/SELENON/SMYD1/HOXD9/XK/MYLK/BMP10/CAV2/MSX1/MTPN/KLF5/SAV1/DDX39B 22 BP GO:0019216 regulation of lipid metabolic process 22/689 410/18670 0.05169 0.4042 0.375 G0S2/PTGS2/SOCS3/PRKAG2/EGR1/MVK/LACTB/AKR1C3/KLF4/LAMTOR1/PTK2/FBXW7/CEACAM1/GPAM/P2RY12/RUBCN/LEP/HELZ2/NR1D1/PRKCE/CHRM5/THRA 22 BP GO:0018105 peptidyl-serine phosphorylation 17/689 299/18670 0.0523 0.4082 0.3788 PTGS2/RAMP3/OSM/APP/NLK/RIPK2/NCK2/TBK1/OPRD1/ATP2B4/ROCK2/TSSK6/SGK1/MASTL/PRKCE/TTBK2/PLK1 17 BP GO:1903524 positive regulation of blood circulation 6/689 73/18670 0.05244 0.4086 0.3792 PTGS2/TPM1/GCH1/ICAM1/ADRA1B/CCN2 6 BP GO:0003205 cardiac chamber development 11/689 171/18670 0.05252 0.4087 0.3792 TPM1/ADAMTS1/ACVR1/HES1/SNX17/BMP10/TMEM65/TAB1/DCTN5/NOS3/SAV1 11 BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 12/689 192/18670 0.05291 0.4109 0.3812 EGF/OSM/ICAM1/SOCS3/PARP14/ACVR1/RIPK2/FBXW7/HES1/LEP/ITGB3/IL15 12 BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 15/689 256/18670 0.0531 0.4109 0.3812 EGF/OSM/ICAM1/APP/SOCS3/PARP14/ACVR1/RIPK2/NCK2/FBXW7/HES1/LEP/PRKCE/ITGB3/IL15 15 BP GO:0006816 calcium ion transport 23/689 434/18670 0.05315 0.4109 0.3812 PTGS2/SESTD1/RAMP3/EGF/PDE4B/ICAM1/PKD2/PANX1/SELENON/OPRD1/ATP2B4/MYLK/P2RY12/TLR9/CCN2/CATSPER3/ITPR2/BIN1/PRKCE/EHD3/NOS3/CDH23/YME1L1 23 BP GO:0050673 epithelial cell proliferation 23/689 434/18670 0.05315 0.4109 0.3812 EGR3/STAT1/TNFAIP3/ZFP36/GLUL/CYP7B1/FBXW7/HES1/CEACAM1/MIR26A1/THBS1/HRAS/DLX6/LEP/MIR129-1/CAV2/NR1D1/ITGB3/IHH/BCL2L2/MIR22/SAV1/ZNF580 23 BP GO:0035710 CD4-positive, alpha-beta T cell activation 7/689 92/18670 0.05358 0.4135 0.3837 NFKBIZ/RIPK2/ARG2/CD83/TWSG1/LOXL3/BATF 7 BP GO:1902807 negative regulation of cell cycle G1/S phase transition 9/689 131/18670 0.0537 0.4137 0.3839 BTG2/PLK3/PLAGL1/PKD2/FHL1/KLF4/CTDSPL/MIR26A1/BTN2A2 9 BP GO:0002697 regulation of immune effector process 24/689 458/18670 0.05444 0.4151 0.3852 STAT1/NFKBIZ/TRAF3/TNFAIP3/MUL1/DDX58/RIOK3/RIPK2/SERPING1/CLU/C5/NCR1/GPATCH3/CEACAM1/SPON2/TLR9/LEP/TRIM38/LOXL3/SH2D1B/IL15/TNFRSF4/DDX60/CPN2 24 BP GO:0007257 activation of JUN kinase activity 4/689 39/18670 0.05459 0.4151 0.3852 MAP4K2/MUL1/RIPK2/TAOK1 4 BP GO:0030488 tRNA methylation 4/689 39/18670 0.05459 0.4151 0.3852 METTL2A/METTL2B/FTSJ1/LCMT2 4 BP GO:0033574 response to testosterone 4/689 39/18670 0.05459 0.4151 0.3852 DUSP1/XRN1/THBS1/ROCK2 4 BP GO:0050856 regulation of T cell receptor signaling pathway 4/689 39/18670 0.05459 0.4151 0.3852 GBP1/PHPT1/CEACAM1/BTN2A2 4 BP GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/689 39/18670 0.05459 0.4151 0.3852 ICAM1/TNFAIP3/FAIM/NOS3 4 BP GO:1901293 nucleoside phosphate biosynthetic process 21/689 390/18670 0.05466 0.4151 0.3852 PTGS2/PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/GPAM/PGK1/APRT/ADPGK/RNLS/AGPAT1/GUCY1A1/NME7/NOS3/AK9/UCK2 21 BP GO:0000082 G1/S transition of mitotic cell cycle 16/689 279/18670 0.05491 0.4151 0.3852 BTG2/ADAMTS1/PLK3/PLAGL1/PKD2/MAX/ACVR1/FHL1/KLF4/RCC1/CTDSPL/MIR26A1/PIM2/TFDP3/AIF1/BTN2A2 16 BP GO:0010332 response to gamma radiation 5/689 56/18670 0.05509 0.4151 0.3852 EGR1/POLB/TSPYL5/CCL7/HRAS 5 BP GO:0034508 centromere complex assembly 5/689 56/18670 0.05509 0.4151 0.3852 RNF4/CENPC/H3-3B/CENPS/H4C8 5 BP GO:0070936 protein K48-linked ubiquitination 5/689 56/18670 0.05509 0.4151 0.3852 AMFR/RNF4/TNFAIP3/PELI1/TRIM38 5 BP GO:0072528 pyrimidine-containing compound biosynthetic process 5/689 56/18670 0.05509 0.4151 0.3852 NME4/GPAM/AGPAT1/NME7/UCK2 5 BP GO:0098586 cellular response to virus 5/689 56/18670 0.05509 0.4151 0.3852 IFIH1/DDX58/RIOK3/GPATCH3/DDX60 5 BP GO:1903078 positive regulation of protein localization to plasma membrane 5/689 56/18670 0.05509 0.4151 0.3852 RAMP3/CNPY4/VIL1/PRKCE/RAB11A 5 BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 6/689 74/18670 0.05537 0.4151 0.3852 DUSP1/GBP1/KLF4/C3orf33/SIRT3/BTN2A2 6 BP GO:0000187 activation of MAPK activity 10/689 152/18670 0.05538 0.4151 0.3852 EGF/MAP4K2/MOS/MUL1/PRDX2/RIPK2/C5/THBS1/TAOK1/TAB1 10 BP GO:0030902 hindbrain development 10/689 152/18670 0.05538 0.4151 0.3852 EGR2/EGF/HOXB3/HES1/MTPN/OTX1/AIF1/SDF4/TTBK2/RBFOX2 10 BP GO:0034599 cellular response to oxidative stress 17/689 302/18670 0.05637 0.4151 0.3852 TPM1/NR4A2/FOS/GCH1/PKD2/GUCY1B1/TNFAIP3/PRDX2/AKR1C3/KLF4/FBXW7/STAU1/MCL1/AIF1/NOS3/SETX/ZNF580 17 BP GO:0034765 regulation of ion transmembrane transport 25/689 483/18670 0.05667 0.4151 0.3852 CLIC3/SESTD1/RAMP3/PDE4B/APP/VAMP2/DNAJC30/PKD2/CNIH3/YWHAH/FHL1/KCNJ13/PM20D1/CLIC4/CHCHD10/SELENON/MIR26A1/ATP2B4/THBS1/TLR9/CATSPER3/STOM/BIN1/PRKCE/EHD3 25 BP GO:0070838 divalent metal ion transport 25/689 483/18670 0.05667 0.4151 0.3852 PTGS2/SESTD1/RAMP3/EGF/PDE4B/ICAM1/PKD2/PANX1/SLC39A14/SELENON/OPRD1/ATP2B4/NIPAL1/MYLK/P2RY12/TLR9/CCN2/CATSPER3/ITPR2/BIN1/PRKCE/EHD3/NOS3/CDH23/YME1L1 25 BP GO:0007141 male meiosis I 3/689 24/18670 0.05697 0.4151 0.3852 DMC1/REC8/ING2 3 BP GO:0009110 vitamin biosynthetic process 3/689 24/18670 0.05697 0.4151 0.3852 MMACHC/PSAT1/UBIAD1 3 BP GO:0009218 pyrimidine ribonucleotide metabolic process 3/689 24/18670 0.05697 0.4151 0.3852 NME4/NME7/UCK2 3 BP GO:0009309 amine biosynthetic process 3/689 24/18670 0.05697 0.4151 0.3852 SAT1/ODC1/SMOX 3 BP GO:0032528 microvillus organization 3/689 24/18670 0.05697 0.4151 0.3852 FSCN1/VIL1/KLF5 3 BP GO:0046426 negative regulation of JAK-STAT cascade 3/689 24/18670 0.05697 0.4151 0.3852 SOCS3/PARP14/LEPROT 3 BP GO:2000209 regulation of anoikis 3/689 24/18670 0.05697 0.4151 0.3852 TLE1/PTK2/MCL1 3 BP GO:0034250 positive regulation of cellular amide metabolic process 10/689 153/18670 0.0574 0.4151 0.3852 PPP1R15A/APP/PLK3/CLU/NCK2/THBS1/ROCK2/PABPC1/BOLL/DDX39B 10 BP GO:0016050 vesicle organization 18/689 325/18670 0.05752 0.4151 0.3852 TAP2/UVRAG/NAPA/CNIH3/SAMD9L/TRAPPC2L/VTI1B/LAMTOR1/PREB/ANKFY1/STX17/DTNBP1/CAV2/TAP1/TRAPPC9/RAB11A/SAMD9/LAPTM4B 18 BP GO:0003007 heart morphogenesis 15/689 259/18670 0.05759 0.4151 0.3852 TPM1/ADAMTS1/PKD2/MYOM1/ACVR1/PTK2/HES1/NOTO/BMP10/MSX1/KDM6A/TAB1/IHH/NOS3/SAV1 15 BP GO:0042770 signal transduction in response to DNA damage 9/689 133/18670 0.05803 0.4151 0.3852 PMAIP1/BTG2/NBN/PLK3/PLAGL1/CDC14B/MSX1/PLK1/BATF 9 BP GO:0021536 diencephalon development 6/689 75/18670 0.0584 0.4151 0.3852 NR4A2/GSX1/PITX1/HES1/MSX1/OTX1 6 BP GO:0043242 negative regulation of protein complex disassembly 6/689 75/18670 0.0584 0.4151 0.3852 TMOD2/RUBCN/TAOK1/VIL1/MTPN/TTBK2 6 BP GO:0150076 neuroinflammatory response 6/689 75/18670 0.0584 0.4151 0.3852 PTGS2/APP/CLU/MIR26A1/NR1D1/AIF1 6 BP GO:0051048 negative regulation of secretion 14/689 238/18670 0.05866 0.4151 0.3852 GBP1/EGF/OSM/BMP8A/TNFAIP3/ARG2/RHBDF2/CEACAM1/P2RY12/SPX/LEP/SYTL4/TNFRSF4/BTN2A2 14 BP GO:0000726 non-recombinational repair 7/689 94/18670 0.05887 0.4151 0.3852 UVRAG/NBN/POLB/OGG1/MDC1/H4C8/SMCHD1 7 BP GO:0051188 cofactor biosynthetic process 18/689 326/18670 0.05889 0.4151 0.3852 PTGS2/PPCDC/GCH1/MMACHC/ELOVL4/APP/PRKAG2/SCD5/NUP188/PTS/PSAT1/PPTC7/PGK1/ADPGK/RNLS/PPOX/COQ4/UBIAD1 18 BP GO:0046394 carboxylic acid biosynthetic process 24/689 462/18670 0.05893 0.4151 0.3852 PTGS2/GCH1/PTGDS/MGLL/EGF/ELOVL4/GGTA1P/APP/PRKAG2/SCD5/NUP188/GLUL/CYP7B1/PSAT1/PLOD2/AKR1C3/CEACAM1/ATP2B4/PGK1/ACOT4/ADPGK/PTGS1/NR1D1/SEPHS1 24 BP GO:0009187 cyclic nucleotide metabolic process 4/689 40/18670 0.05896 0.4151 0.3852 PDE4B/GUCY1B1/GUCY1A1/PDE5A 4 BP GO:0042036 negative regulation of cytokine biosynthetic process 4/689 40/18670 0.05896 0.4151 0.3852 ZFP36/KLF4/MIR26A1/SIGIRR 4 BP GO:0072210 metanephric nephron development 4/689 40/18670 0.05896 0.4151 0.3852 STAT1/PKD2/EGR1/HES1 4 BP GO:2000008 regulation of protein localization to cell surface 4/689 40/18670 0.05896 0.4151 0.3852 EGF/MAP1A/LEPROT/CD247 4 BP GO:0090501 RNA phosphodiester bond hydrolysis 10/689 154/18670 0.05946 0.4151 0.3852 XRN1/EDC3/PCF11/RNASEH2B/TOE1/HELZ2/AGO2/ISG20/MOV10/TSEN54 10 BP GO:0070482 response to oxygen levels 21/689 394/18670 0.05957 0.4151 0.3852 PTGS2/PMAIP1/ATP6V0A2/NR4A2/SLC2A1/ICAM1/PLK3/EGR1/POLB/PDLIM1/PLOD2/CHCHD2/OPRD1/PGK1/THBS1/CCN2/ROCK2/MPL/ITPR2/LEP/PRKCE 21 BP GO:0000185 activation of MAPKKK activity 2/689 11/18670 0.05999 0.4151 0.3852 MAP4K2/TAB1 2 BP GO:0001778 plasma membrane repair 2/689 11/18670 0.05999 0.4151 0.3852 SYTL4/MYOF 2 BP GO:0006182 cGMP biosynthetic process 2/689 11/18670 0.05999 0.4151 0.3852 GUCY1B1/GUCY1A1 2 BP GO:0006183 GTP biosynthetic process 2/689 11/18670 0.05999 0.4151 0.3852 NME4/NME7 2 BP GO:0018095 protein polyglutamylation 2/689 11/18670 0.05999 0.4151 0.3852 TTLL1/TPGS1 2 BP GO:0021521 ventral spinal cord interneuron specification 2/689 11/18670 0.05999 0.4151 0.3852 NKX6-2/EVX1 2 BP GO:0032908 regulation of transforming growth factor beta1 production 2/689 11/18670 0.05999 0.4151 0.3852 THBS1/LAPTM4B 2 BP GO:0033089 positive regulation of T cell differentiation in thymus 2/689 11/18670 0.05999 0.4151 0.3852 EGR3/IHH 2 BP GO:0035739 CD4-positive, alpha-beta T cell proliferation 2/689 11/18670 0.05999 0.4151 0.3852 ARG2/TWSG1 2 BP GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 2/689 11/18670 0.05999 0.4151 0.3852 RIOK3/GPATCH3 2 BP GO:0043117 positive regulation of vascular permeability 2/689 11/18670 0.05999 0.4151 0.3852 PDE3A/FGFBP3 2 BP GO:0045351 type I interferon biosynthetic process 2/689 11/18670 0.05999 0.4151 0.3852 TBK1/TLR9 2 BP GO:0046007 negative regulation of activated T cell proliferation 2/689 11/18670 0.05999 0.4151 0.3852 PDCD1LG2/BTN2A2 2 BP GO:0046051 UTP metabolic process 2/689 11/18670 0.05999 0.4151 0.3852 NME4/NME7 2 BP GO:0060159 regulation of dopamine receptor signaling pathway 2/689 11/18670 0.05999 0.4151 0.3852 DTNBP1/CAV2 2 BP GO:0060573 cell fate specification involved in pattern specification 2/689 11/18670 0.05999 0.4151 0.3852 NKX6-2/EVX1 2 BP GO:0060992 response to fungicide 2/689 11/18670 0.05999 0.4151 0.3852 XRN1/KLF4 2 BP GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/689 11/18670 0.05999 0.4151 0.3852 PPP1R15A/NCK2 2 BP GO:1902946 protein localization to early endosome 2/689 11/18670 0.05999 0.4151 0.3852 EGF/ROCK2 2 BP GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 2/689 11/18670 0.05999 0.4151 0.3852 KLF4/CCL28 2 BP GO:1905245 regulation of aspartic-type peptidase activity 2/689 11/18670 0.05999 0.4151 0.3852 ROCK2/BIN1 2 BP GO:1905668 positive regulation of protein localization to endosome 2/689 11/18670 0.05999 0.4151 0.3852 EGF/ROCK2 2 BP GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 2/689 11/18670 0.05999 0.4151 0.3852 ARG2/TWSG1 2 BP GO:0016053 organic acid biosynthetic process 24/689 463/18670 0.06009 0.4151 0.3852 PTGS2/GCH1/PTGDS/MGLL/EGF/ELOVL4/GGTA1P/APP/PRKAG2/SCD5/NUP188/GLUL/CYP7B1/PSAT1/PLOD2/AKR1C3/CEACAM1/ATP2B4/PGK1/ACOT4/ADPGK/PTGS1/NR1D1/SEPHS1 24 BP GO:0030260 entry into host cell 9/689 134/18670 0.06028 0.4151 0.3852 UVRAG/CXCL8/ICAM1/TRIM26/ITGB5/CAV2/ITGB3/TRIM38/TNFRSF4 9 BP GO:0032355 response to estradiol 9/689 134/18670 0.06028 0.4151 0.3852 PTGS2/DUSP1/RAMP3/OGG1/CCN2/LEP/NRIP1/IHH/BCL2L2 9 BP GO:0044409 entry into host 9/689 134/18670 0.06028 0.4151 0.3852 UVRAG/CXCL8/ICAM1/TRIM26/ITGB5/CAV2/ITGB3/TRIM38/TNFRSF4 9 BP GO:0051806 entry into cell of other organism involved in symbiotic interaction 9/689 134/18670 0.06028 0.4151 0.3852 UVRAG/CXCL8/ICAM1/TRIM26/ITGB5/CAV2/ITGB3/TRIM38/TNFRSF4 9 BP GO:0051828 entry into other organism involved in symbiotic interaction 9/689 134/18670 0.06028 0.4151 0.3852 UVRAG/CXCL8/ICAM1/TRIM26/ITGB5/CAV2/ITGB3/TRIM38/TNFRSF4 9 BP GO:0046677 response to antibiotic 18/689 327/18670 0.06029 0.4151 0.3852 DUSP1/XRN1/STAT1/ICAM1/EGR1/TNFAIP3/POLB/OGG1/CLU/KLF4/CCL7/ID3/ITPR2/LEP/PRKCE/SDF4/SETX/ZNF580 18 BP GO:0009108 coenzyme biosynthetic process 15/689 261/18670 0.06072 0.4174 0.3874 PTGS2/PPCDC/GCH1/ELOVL4/APP/PRKAG2/SCD5/NUP188/PTS/PPTC7/PGK1/ADPGK/RNLS/COQ4/UBIAD1 15 BP GO:0032409 regulation of transporter activity 16/689 283/18670 0.06082 0.4175 0.3874 PDE4B/APP/VAMP2/PKD2/CNIH3/YWHAH/FHL1/PM20D1/CHCHD10/SELENON/MIR26A1/TLR9/SGK1/STOM/PRKCE/EHD3 16 BP GO:0032271 regulation of protein polymerization 13/689 218/18670 0.06123 0.4198 0.3895 TMOD2/ICAM1/RHOBTB1/ARHGAP18/CTTN/NCK2/NCKAP1/ACTR3B/VIL1/MTPN/RHOBTB2/BIN1/PRKCE 13 BP GO:0001937 negative regulation of endothelial cell proliferation 6/689 76/18670 0.06152 0.4201 0.3898 STAT1/MIR26A1/THBS1/MIR129-1/CAV2/MIR22 6 BP GO:0042116 macrophage activation 7/689 95/18670 0.06163 0.4201 0.3898 APP/JMJD6/CLU/THBS1/NR1D1/AIF1/PRKCE 7 BP GO:0097711 ciliary basal body-plasma membrane docking 7/689 95/18670 0.06163 0.4201 0.3898 TCTN2/SCLT1/CNTRL/IQCB1/TTBK2/RAB11A/PLK1 7 BP GO:1903076 regulation of protein localization to plasma membrane 7/689 95/18670 0.06163 0.4201 0.3898 RAMP3/GBP1/VTI1B/CNPY4/VIL1/PRKCE/RAB11A 7 BP GO:0001701 in utero embryonic development 20/689 373/18670 0.06172 0.4201 0.3898 TPM1/CMIP/HOPX/NBN/SOCS3/JUNB/BTF3/PKD2/EIF4E2/POLB/ACVR1/HES1/RNASEH2B/GNA13/MSX1/SPINT2/KDM6A/TAB1/IHH/NOS3 20 BP GO:0050796 regulation of insulin secretion 11/689 176/18670 0.06201 0.4215 0.3911 SLC2A1/BMP8A/GLUL/PHPT1/CDK16/ITPR2/LEP/SYTL4/NR1D1/SIRT3/PRKCE 11 BP GO:0061951 establishment of protein localization to plasma membrane 5/689 58/18670 0.06231 0.4224 0.392 ARL6/VAMP2/RAB31/BLZF1/RAB11A 5 BP GO:0007281 germ cell development 15/689 262/18670 0.06233 0.4224 0.392 PDE3A/DND1/ACVR1/H3-3B/GDF9/TTLL1/DMC1/CATSPER3/REC8/TSSK6/TPGS1/PDE5A/ING2/BOLL/IHH 15 BP GO:0030010 establishment of cell polarity 9/689 135/18670 0.06258 0.4229 0.3924 FSCN1/MOS/PARD3/MPP7/PTK2/HES1/ROCK2/PLK1/SAPCD2 9 BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 9/689 135/18670 0.06258 0.4229 0.3924 MUL1/RIPK2/TSPYL5/CDC14B/FBXW7/PELI1/CENPS/MASTL/PLK1 9 BP GO:0019430 removal of superoxide radicals 3/689 25/18670 0.06303 0.423 0.3925 GCH1/PRDX2/NOS3 3 BP GO:0050901 leukocyte tethering or rolling 3/689 25/18670 0.06303 0.423 0.3925 LEP/SELP/CCL28 3 BP GO:0060330 regulation of response to interferon-gamma 3/689 25/18670 0.06303 0.423 0.3925 STAT1/SOCS3/PARP14 3 BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 3/689 25/18670 0.06303 0.423 0.3925 STAT1/SOCS3/PARP14 3 BP GO:0072273 metanephric nephron morphogenesis 3/689 25/18670 0.06303 0.423 0.3925 STAT1/PKD2/HES1 3 BP GO:0097178 ruffle assembly 4/689 41/18670 0.06351 0.4244 0.3938 ICAM1/P2RY12/HRAS/AIF1 4 BP GO:1903170 negative regulation of calcium ion transmembrane transport 4/689 41/18670 0.06351 0.4244 0.3938 SESTD1/PKD2/TLR9/BIN1 4 BP GO:0072511 divalent inorganic cation transport 25/689 489/18670 0.06351 0.4244 0.3938 PTGS2/SESTD1/RAMP3/EGF/PDE4B/ICAM1/PKD2/PANX1/SLC39A14/SELENON/OPRD1/ATP2B4/NIPAL1/MYLK/P2RY12/TLR9/CCN2/CATSPER3/ITPR2/BIN1/PRKCE/EHD3/NOS3/CDH23/YME1L1 25 BP GO:0048469 cell maturation 11/689 177/18670 0.06403 0.4273 0.3965 PDE3A/NR4A2/APP/SCLT1/HES1/DMC1/CATSPER3/REC8/CLEC7A/IHH/IL15 11 BP GO:0008585 female gonad development 7/689 96/18670 0.06447 0.4291 0.3981 ICAM1/ADAMTS1/GDF9/DMC1/LEP/NRIP1/NOS3 7 BP GO:0048010 vascular endothelial growth factor receptor signaling pathway 7/689 96/18670 0.06447 0.4291 0.3981 SH2D2A/NCK2/PTK2/NCKAP1/ROCK2/ITGB3/MYOF 7 BP GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 6/689 77/18670 0.06474 0.4293 0.3983 BTG2/EDC3/PATL1/ZFP36/AGO2/PABPC1 6 BP GO:0048678 response to axon injury 6/689 77/18670 0.06474 0.4293 0.3983 MAX/RTN4RL1/KLF4/P2RY12/RTN4R/AIF1 6 BP GO:0001503 ossification 21/689 398/18670 0.06477 0.4293 0.3983 PTGS2/EGR2/JUNB/BMP8A/JUND/CTSK/KLF10/ACVR1/GLIS1/H3-3B/PTK2/ID3/RRAS2/CCN2/BMP8B/LEP/TWSG1/IHH/MATN1/THRA/PBX1 21 BP GO:1901990 regulation of mitotic cell cycle phase transition 23/689 444/18670 0.06498 0.4301 0.3991 DUSP1/TPRA1/BTG2/NBN/APP/ADAMTS1/PLK3/PLAGL1/PKD2/FHL1/CDC14B/KLF4/CNTRL/CTDSPL/MIR26A1/RNASEH2B/TAOK1/AIF1/RAB11A/PLK1/PBX1/ANAPC1/BTN2A2 23 BP GO:0030098 lymphocyte differentiation 19/689 353/18670 0.06532 0.4313 0.4002 EGR3/NFKBIZ/IRF1/EGR1/PRDX2/JMJD6/RIPK2/LEPR/KLF6/TLR9/LEP/CD83/ATP11C/IHH/ZAP70/LOXL3/IL15/BTN2A2/BATF 19 BP GO:0021782 glial cell development 8/689 116/18670 0.06535 0.4313 0.4002 APP/NKX6-2/PARD3/CLU/MIR26A1/ROR1/NR1D1/WASF3 8 BP GO:0031330 negative regulation of cellular catabolic process 15/689 264/18670 0.06563 0.4326 0.4014 DND1/ZFP36/MAP1A/LEPR/PTK2/LAMP3/ATP2B4/RASIP1/USP25/MCL1/RUBCN/LEP/PABPC1/BOLL/LAPTM4B 15 BP GO:0031570 DNA integrity checkpoint 10/689 157/18670 0.06593 0.4334 0.4021 BTG2/NBN/PLK3/PLAGL1/CDC14B/MDC1/RNASEH2B/TAOK1/PLK1/DDX39B 10 BP GO:0050821 protein stabilization 11/689 178/18670 0.0661 0.4334 0.4021 NLK/MUL1/CLU/HYPK/FBXW7/PIM2/TAF9B/MSX1/PER3/SAV1/CPN2 11 BP GO:0032732 positive regulation of interleukin-1 production 5/689 59/18670 0.06611 0.4334 0.4021 APP/EGR1/RIPK2/PANX1/CLEC7A 5 BP GO:0097755 positive regulation of blood vessel diameter 5/689 59/18670 0.06611 0.4334 0.4021 GCH1/ADRB3/LEP/GUCY1A1/NOS3 5 BP GO:0031589 cell-substrate adhesion 19/689 354/18670 0.06677 0.4371 0.4055 PHLDB2/SLK/GBP1/FBLN2/GCNT2/TESK2/EMILIN2/PLG/CTTN/PTK2/ONECUT2/THBS1/CCN2/ROCK2/MMRN1/ITGB5/PRKCE/ITGB3/CCL28 19 BP GO:0031644 regulation of neurological system process 9/689 137/18670 0.06735 0.4387 0.4071 MGLL/APP/PARD3/OPRD1/ROCK2/SPX/WASF3/NOS3/NPTX2 9 BP GO:0046425 regulation of JAK-STAT cascade 9/689 137/18670 0.06735 0.4387 0.4071 EGF/OSM/SOCS3/NLK/PARP14/LEPROT/HES1/LEP/IL15 9 BP GO:0006942 regulation of striated muscle contraction 7/689 97/18670 0.06739 0.4387 0.4071 PDE4B/ADRA1B/CCN2/BMP10/PDE5A/BIN1/EHD3 7 BP GO:0007044 cell-substrate junction assembly 7/689 97/18670 0.06739 0.4387 0.4071 PHLDB2/SLK/TESK2/CTTN/PTK2/THBS1/ROCK2 7 BP GO:0010508 positive regulation of autophagy 8/689 117/18670 0.068 0.4406 0.4089 UVRAG/PLK3/NPRL2/MUL1/RIPK2/TBK1/PIM2/CALCOCO2 8 BP GO:0031398 positive regulation of protein ubiquitination 8/689 117/18670 0.068 0.4406 0.4089 RIPK2/TSPYL5/CDC14B/FBXW7/PELI1/CENPS/MASTL/PLK1 8 BP GO:0008306 associative learning 6/689 78/18670 0.06806 0.4406 0.4089 FOS/BTG2/APP/MAP1A/NRGN/NPTX2 6 BP GO:0048771 tissue remodeling 11/689 179/18670 0.06821 0.4406 0.4089 TNFAIP3/CTSK/PLG/LEPR/CEACAM1/ROCK2/LEP/ITGB3/IHH/NOS3/IL15 11 BP GO:0006284 base-excision repair 4/689 42/18670 0.06824 0.4406 0.4089 MUTYH/POLB/OGG1/HMGA1 4 BP GO:0021983 pituitary gland development 4/689 42/18670 0.06824 0.4406 0.4089 GSX1/PITX1/HES1/MSX1 4 BP GO:0001556 oocyte maturation 3/689 26/18670 0.06938 0.4407 0.4089 PDE3A/DMC1/REC8 3 BP GO:0042745 circadian sleep/wake cycle 3/689 26/18670 0.06938 0.4407 0.4089 PTGDS/PER3/NR1D1 3 BP GO:0048169 regulation of long-term neuronal synaptic plasticity 3/689 26/18670 0.06938 0.4407 0.4089 APP/HRAS/RAB11A 3 BP GO:0072539 T-helper 17 cell differentiation 3/689 26/18670 0.06938 0.4407 0.4089 NFKBIZ/LOXL3/BATF 3 BP GO:1990778 protein localization to cell periphery 17/689 311/18670 0.06989 0.4407 0.4089 RAMP3/GBP1/ARL6/VAMP2/TSPAN33/VTI1B/RAB31/ROCK2/HRAS/CNPY4/VIL1/BLZF1/PRKCE/EHD3/RAB11A/PLK1/SAPCD2 17 BP GO:0051893 regulation of focal adhesion assembly 5/689 60/18670 0.07004 0.4407 0.4089 PHLDB2/SLK/PTK2/THBS1/ROCK2 5 BP GO:0090109 regulation of cell-substrate junction assembly 5/689 60/18670 0.07004 0.4407 0.4089 PHLDB2/SLK/PTK2/THBS1/ROCK2 5 BP GO:0007288 sperm axoneme assembly 2/689 12/18670 0.07027 0.4407 0.4089 TTLL1/TPGS1 2 BP GO:0032905 transforming growth factor beta1 production 2/689 12/18670 0.07027 0.4407 0.4089 THBS1/LAPTM4B 2 BP GO:0042416 dopamine biosynthetic process 2/689 12/18670 0.07027 0.4407 0.4089 NR4A2/GCH1 2 BP GO:0045080 positive regulation of chemokine biosynthetic process 2/689 12/18670 0.07027 0.4407 0.4089 APP/EGR1 2 BP GO:0045416 positive regulation of interleukin-8 biosynthetic process 2/689 12/18670 0.07027 0.4407 0.4089 TLR9/CLEC7A 2 BP GO:0048934 peripheral nervous system neuron differentiation 2/689 12/18670 0.07027 0.4407 0.4089 ONECUT2/HOXD9 2 BP GO:0048935 peripheral nervous system neuron development 2/689 12/18670 0.07027 0.4407 0.4089 ONECUT2/HOXD9 2 BP GO:0051132 NK T cell activation 2/689 12/18670 0.07027 0.4407 0.4089 IL15/ELF4 2 BP GO:0051657 maintenance of organelle location 2/689 12/18670 0.07027 0.4407 0.4089 UVRAG/ARHGAP21 2 BP GO:0060670 branching involved in labyrinthine layer morphogenesis 2/689 12/18670 0.07027 0.4407 0.4089 SOCS3/SPINT2 2 BP GO:0072520 seminiferous tubule development 2/689 12/18670 0.07027 0.4407 0.4089 REC8/ING2 2 BP GO:0072540 T-helper 17 cell lineage commitment 2/689 12/18670 0.07027 0.4407 0.4089 LOXL3/BATF 2 BP GO:0072697 protein localization to cell cortex 2/689 12/18670 0.07027 0.4407 0.4089 PLK1/SAPCD2 2 BP GO:0099550 trans-synaptic signaling, modulating synaptic transmission 2/689 12/18670 0.07027 0.4407 0.4089 GUCY1B1/GUCY1A1 2 BP GO:1905666 regulation of protein localization to endosome 2/689 12/18670 0.07027 0.4407 0.4089 EGF/ROCK2 2 BP GO:0002042 cell migration involved in sprouting angiogenesis 7/689 98/18670 0.07039 0.4408 0.4091 PTGS2/EGR3/KLF4/FBXW7/MIR26A1/THBS1/MIR22 7 BP GO:0045652 regulation of megakaryocyte differentiation 6/689 79/18670 0.07148 0.4471 0.4149 H3-3B/GP1BA/THBS1/MYL9/H4C8/MOV10 6 BP GO:0006732 coenzyme metabolic process 21/689 403/18670 0.07171 0.4474 0.4152 PTGS2/GPD2/PPCDC/GCH1/SLC2A1/ELOVL4/APP/PRKAG2/SCD5/NUP188/MVK/PTS/PPTC7/PGK1/ACOT4/ADPGK/FAR2/RNLS/COQ4/VNN3/UBIAD1 21 BP GO:0050852 T cell receptor signaling pathway 12/689 202/18670 0.07172 0.4474 0.4152 GBP1/PDE4B/NFKBIZ/RIPK2/PHPT1/CEACAM1/RNF31/SPPL3/HRAS/CD247/ZAP70/BTN2A2 12 BP GO:0033135 regulation of peptidyl-serine phosphorylation 9/689 139/18670 0.07235 0.4508 0.4183 PTGS2/RAMP3/OSM/APP/RIPK2/NCK2/TBK1/OPRD1/ATP2B4 9 BP GO:0022898 regulation of transmembrane transporter activity 15/689 268/18670 0.07258 0.451 0.4185 PDE4B/APP/VAMP2/PKD2/CNIH3/YWHAH/FHL1/PM20D1/CHCHD10/SELENON/MIR26A1/TLR9/STOM/PRKCE/EHD3 15 BP GO:0050714 positive regulation of protein secretion 15/689 268/18670 0.07258 0.451 0.4185 OSM/MYOM1/IFIH1/DDX58/GLUL/RIPK2/PANX1/PHPT1/C5/C1QTNF4/SYTL4/AIF1/SIRT3/PRKCE/TNFRSF4 15 BP GO:0048872 homeostasis of number of cells 14/689 246/18670 0.0727 0.4512 0.4187 PMAIP1/STAT1/PDE4B/TNFAIP3/POLB/ZFP36/PRDX2/JMJD6/TSC22D3/SMAP1/MPL/NOS3/THRA/RBFOX2 14 BP GO:0006692 prostanoid metabolic process 4/689 43/18670 0.07314 0.4516 0.419 PTGS2/PTGDS/AKR1C3/PTGS1 4 BP GO:0006693 prostaglandin metabolic process 4/689 43/18670 0.07314 0.4516 0.419 PTGS2/PTGDS/AKR1C3/PTGS1 4 BP GO:0032459 regulation of protein oligomerization 4/689 43/18670 0.07314 0.4516 0.419 PMAIP1/RIOK3/CLU/OPRD1 4 BP GO:0033173 calcineurin-NFAT signaling cascade 4/689 43/18670 0.07314 0.4516 0.419 ATP2B4/SPPL3/LMCD1/CAMTA1 4 BP GO:0007173 epidermal growth factor receptor signaling pathway 8/689 119/18670 0.07349 0.4532 0.4205 EGF/APP/NCK2/PTK2/RHBDF2/FBXW7/CEACAM1/VIL1 8 BP GO:0050701 interleukin-1 secretion 5/689 61/18670 0.0741 0.4551 0.4223 GBP5/TNFAIP3/RIPK2/ARG2/PANX1 5 BP GO:1905953 negative regulation of lipid localization 5/689 61/18670 0.0741 0.4551 0.4223 EGF/MIR26A1/THBS1/LEP/ITGB3 5 BP GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 5/689 61/18670 0.0741 0.4551 0.4223 PMAIP1/NCK2/FBXW7/MCL1/MSX1 5 BP GO:0043491 protein kinase B signaling 15/689 269/18670 0.07439 0.4563 0.4234 RAMP3/EGF/OSM/PLK3/GCNT2/MUL1/TSPYL5/AKR1C3/KLF4/PTK2/THBS1/P2RY12/LEP/SETX/BTN2A2 15 BP GO:0043405 regulation of MAP kinase activity 18/689 337/18670 0.0755 0.4621 0.4287 DUSP1/EGF/MAP4K2/MOS/MUL1/PRDX2/LAX1/RIPK2/C5/THBS1/TLR9/SMPD1/HRAS/TAOK1/DTNBP1/PDE5A/TAB1/TRIB1 18 BP GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 3/689 27/18670 0.076 0.4621 0.4287 APP/RAB11A/PBX1 3 BP GO:0061437 renal system vasculature development 3/689 27/18670 0.076 0.4621 0.4287 PKD2/EGR1/HES1 3 BP GO:0061440 kidney vasculature development 3/689 27/18670 0.076 0.4621 0.4287 PKD2/EGR1/HES1 3 BP GO:0071450 cellular response to oxygen radical 3/689 27/18670 0.076 0.4621 0.4287 GCH1/PRDX2/NOS3 3 BP GO:0071451 cellular response to superoxide 3/689 27/18670 0.076 0.4621 0.4287 GCH1/PRDX2/NOS3 3 BP GO:0072207 metanephric epithelium development 3/689 27/18670 0.076 0.4621 0.4287 STAT1/PKD2/HES1 3 BP GO:1901991 negative regulation of mitotic cell cycle phase transition 14/689 248/18670 0.07653 0.4629 0.4295 DUSP1/TPRA1/BTG2/NBN/PLK3/PLAGL1/PKD2/FHL1/KLF4/CTDSPL/MIR26A1/TAOK1/PLK1/BTN2A2 14 BP GO:0002040 sprouting angiogenesis 11/689 183/18670 0.07707 0.4629 0.4295 PTGS2/EGR3/JMJD6/GLUL/KLF4/FBXW7/CEACAM1/MIR26A1/THBS1/RNF213/MIR22 11 BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 11/689 183/18670 0.07707 0.4629 0.4295 MUL1/RIPK2/TBK1/PELI1/RNF31/PIM2/TLR9/ROR1/PRKCE/TRIM38/PLEKHG5 11 BP GO:0045930 negative regulation of mitotic cell cycle 18/689 338/18670 0.07715 0.4629 0.4295 DUSP1/TPRA1/BTG2/NBN/PLK3/PLAGL1/PKD2/FHL1/CDC14B/KLF4/MDC1/GADD45GIP1/CTDSPL/MIR26A1/HRAS/TAOK1/PLK1/BTN2A2 18 BP GO:0009260 ribonucleotide biosynthetic process 16/689 293/18670 0.07743 0.4629 0.4295 PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/PGK1/APRT/ADPGK/GUCY1A1/NME7/AK9/UCK2 16 BP GO:0051146 striated muscle cell differentiation 16/689 293/18670 0.07743 0.4629 0.4295 TPM1/TMOD2/MYOM1/ACVR1/PLEKHO1/SELENON/SMYD1/XK/BMP10/CAV2/MSX1/PDLIM5/MTPN/MYOF/KLF5/DDX39B 16 BP GO:0014003 oligodendrocyte development 4/689 44/18670 0.07822 0.4629 0.4295 NKX6-2/CLU/MIR26A1/WASF3 4 BP GO:0035307 positive regulation of protein dephosphorylation 4/689 44/18670 0.07822 0.4629 0.4295 PPP1R15A/SPPL3/SMPD1/CAMTA1 4 BP GO:0042987 amyloid precursor protein catabolic process 4/689 44/18670 0.07822 0.4629 0.4295 APP/CLU/ROCK2/BIN1 4 BP GO:0060412 ventricular septum morphogenesis 4/689 44/18670 0.07822 0.4629 0.4295 ACVR1/HES1/NOS3/SAV1 4 BP GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 4/689 44/18670 0.07822 0.4629 0.4295 KLF4/MIR26A1/THBS1/MIR22 4 BP GO:0090382 phagosome maturation 4/689 44/18670 0.07822 0.4629 0.4295 ATP6V0A2/ATP6V0E2/RAB31/ATP6V1G2 4 BP GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4/689 44/18670 0.07822 0.4629 0.4295 PMAIP1/YWHAH/MUL1/CHCHD10 4 BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/689 44/18670 0.07822 0.4629 0.4295 PPP1R15A/CLU/NCK2/USP25 4 BP GO:0003407 neural retina development 5/689 62/18670 0.07828 0.4629 0.4295 ARL6/ATOH7/ATP2B4/CABP4/IHH 5 BP GO:0046635 positive regulation of alpha-beta T cell activation 5/689 62/18670 0.07828 0.4629 0.4295 NFKBIZ/RIPK2/CD83/IHH/ZAP70 5 BP GO:0034109 homotypic cell-cell adhesion 6/689 81/18670 0.0786 0.4629 0.4295 CEACAM1/GP1BA/P2RY12/MPL/MYL9/ITGB3 6 BP GO:0046718 viral entry into host cell 8/689 121/18670 0.07925 0.4629 0.4295 UVRAG/ICAM1/TRIM26/ITGB5/CAV2/ITGB3/TRIM38/TNFRSF4 8 BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 11/689 184/18670 0.0794 0.4629 0.4295 BTG2/ADAMTS1/PLK3/PLAGL1/PKD2/FHL1/KLF4/CTDSPL/MIR26A1/AIF1/BTN2A2 11 BP GO:0046545 development of primary female sexual characteristics 7/689 101/18670 0.07985 0.4629 0.4295 ICAM1/ADAMTS1/GDF9/DMC1/LEP/NRIP1/NOS3 7 BP GO:0070371 ERK1 and ERK2 cascade 17/689 317/18670 0.08003 0.4629 0.4295 DUSP1/RAMP3/GBP1/EGF/ICAM1/APP/GCNT2/RIPK2/KLF4/CCL7/FBXW7/CEACAM1/C3orf33/CCN2/HRAS/SIRT3/BTN2A2 17 BP GO:0018108 peptidyl-tyrosine phosphorylation 19/689 363/18670 0.08077 0.4629 0.4295 EGF/OSM/ICAM1/APP/SOCS3/TESK2/PARP14/ACVR1/RIPK2/NCK2/PTK2/FBXW7/HES1/LEP/ROR1/PRKCE/ITGB3/ZAP70/IL15 19 BP GO:0045862 positive regulation of proteolysis 19/689 363/18670 0.08077 0.4629 0.4295 PMAIP1/EGF/NUB1/APP/PLK3/MUL1/RIPK2/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/PDCD5/CCN2/ROCK2/CLEC7A/RNF19B/PLK1/TRIB1 19 BP GO:0009223 pyrimidine deoxyribonucleotide catabolic process 2/689 13/18670 0.08107 0.4629 0.4295 OGG1/DCTPP1 2 BP GO:0010763 positive regulation of fibroblast migration 2/689 13/18670 0.08107 0.4629 0.4295 THBS1/PRKCE 2 BP GO:0016024 CDP-diacylglycerol biosynthetic process 2/689 13/18670 0.08107 0.4629 0.4295 GPAM/AGPAT1 2 BP GO:0021681 cerebellar granular layer development 2/689 13/18670 0.08107 0.4629 0.4295 MTPN/TTBK2 2 BP GO:0021984 adenohypophysis development 2/689 13/18670 0.08107 0.4629 0.4295 GSX1/HES1 2 BP GO:0032096 negative regulation of response to food 2/689 13/18670 0.08107 0.4629 0.4295 SPX/LEP 2 BP GO:0032099 negative regulation of appetite 2/689 13/18670 0.08107 0.4629 0.4295 SPX/LEP 2 BP GO:0032536 regulation of cell projection size 2/689 13/18670 0.08107 0.4629 0.4295 XK/VIL1 2 BP GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 2/689 13/18670 0.08107 0.4629 0.4295 DDX58/TLR9 2 BP GO:0034214 protein hexamerization 2/689 13/18670 0.08107 0.4629 0.4295 PANX1/YME1L1 2 BP GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/689 13/18670 0.08107 0.4629 0.4295 SOCS3/PARP14 2 BP GO:0043116 negative regulation of vascular permeability 2/689 13/18670 0.08107 0.4629 0.4295 PDE3A/CEACAM1 2 BP GO:0045078 positive regulation of interferon-gamma biosynthetic process 2/689 13/18670 0.08107 0.4629 0.4295 TLR9/CLEC7A 2 BP GO:0045759 negative regulation of action potential 2/689 13/18670 0.08107 0.4629 0.4295 CNR2/BIN1 2 BP GO:0048681 negative regulation of axon regeneration 2/689 13/18670 0.08107 0.4629 0.4295 RTN4RL1/RTN4R 2 BP GO:0048711 positive regulation of astrocyte differentiation 2/689 13/18670 0.08107 0.4629 0.4295 HES1/BIN1 2 BP GO:0050722 regulation of interleukin-1 beta biosynthetic process 2/689 13/18670 0.08107 0.4629 0.4295 APP/EGR1 2 BP GO:0050746 regulation of lipoprotein metabolic process 2/689 13/18670 0.08107 0.4629 0.4295 LEP/ITGB3 2 BP GO:0060347 heart trabecula formation 2/689 13/18670 0.08107 0.4629 0.4295 ADAMTS1/BMP10 2 BP GO:0070103 regulation of interleukin-6-mediated signaling pathway 2/689 13/18670 0.08107 0.4629 0.4295 MIR26A1/C1QTNF4 2 BP GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 2/689 13/18670 0.08107 0.4629 0.4295 TNFAIP3/RIPK2 2 BP GO:0071872 cellular response to epinephrine stimulus 2/689 13/18670 0.08107 0.4629 0.4295 PDE4B/ATP2B4 2 BP GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 2/689 13/18670 0.08107 0.4629 0.4295 SLC35D2/SLC35E2A 2 BP GO:0097152 mesenchymal cell apoptotic process 2/689 13/18670 0.08107 0.4629 0.4295 MSX1/ETV6 2 BP GO:0098703 calcium ion import across plasma membrane 2/689 13/18670 0.08107 0.4629 0.4295 RAMP3/ATP2B4 2 BP GO:1902430 negative regulation of amyloid-beta formation 2/689 13/18670 0.08107 0.4629 0.4295 CLU/BIN1 2 BP GO:1902947 regulation of tau-protein kinase activity 2/689 13/18670 0.08107 0.4629 0.4295 EGR1/CLU 2 BP GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 2/689 13/18670 0.08107 0.4629 0.4295 FBXW7/ZNF593 2 BP GO:0032637 interleukin-8 production 6/689 82/18670 0.08231 0.4671 0.4334 DDX58/KLF4/TLR9/CLEC7A/LEP/ZNF580 6 BP GO:0090049 regulation of cell migration involved in sprouting angiogenesis 6/689 82/18670 0.08231 0.4671 0.4334 PTGS2/KLF4/FBXW7/MIR26A1/THBS1/MIR22 6 BP GO:0034284 response to monosaccharide 12/689 207/18670 0.08255 0.4671 0.4334 PTGS2/ICAM1/VAMP2/EGR1/GLUL/PHPT1/CDK16/THBS1/CCN2/LEP/NR1D1/PRKCE 12 BP GO:0042982 amyloid precursor protein metabolic process 5/689 63/18670 0.08258 0.4671 0.4334 APP/CLU/ROCK2/AGO2/BIN1 5 BP GO:1904377 positive regulation of protein localization to cell periphery 5/689 63/18670 0.08258 0.4671 0.4334 RAMP3/CNPY4/VIL1/PRKCE/RAB11A 5 BP GO:0006633 fatty acid biosynthetic process 10/689 164/18670 0.08274 0.4671 0.4334 PTGS2/PTGDS/MGLL/ELOVL4/PRKAG2/SCD5/AKR1C3/CEACAM1/ACOT4/PTGS1 10 BP GO:0045408 regulation of interleukin-6 biosynthetic process 3/689 28/18670 0.08288 0.4671 0.4334 APP/MIR26A1/CLEC7A 3 BP GO:0045686 negative regulation of glial cell differentiation 3/689 28/18670 0.08288 0.4671 0.4334 NKX6-2/HES1/NR1D1 3 BP GO:0048679 regulation of axon regeneration 3/689 28/18670 0.08288 0.4671 0.4334 RTN4RL1/KLF4/RTN4R 3 BP GO:0090383 phagosome acidification 3/689 28/18670 0.08288 0.4671 0.4334 ATP6V0A2/ATP6V0E2/ATP6V1G2 3 BP GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 3/689 28/18670 0.08288 0.4671 0.4334 ICAM1/KLF4/CCL28 3 BP GO:0044344 cellular response to fibroblast growth factor stimulus 9/689 143/18670 0.08301 0.4671 0.4335 EGR3/CXCL8/GTF2F2/ZFP36/FGFBP3/THBS1/CCN2/SETX/RBFOX2 9 BP GO:0048732 gland development 22/689 434/18670 0.08345 0.4671 0.4335 EGF/PKD2/GSX1/TNFAIP3/POLB/PITX1/PRDX2/CYP7B1/FBXW7/ONECUT2/SERPINC1/HOXB3/HES1/CEACAM1/HOXD9/APRT/MSX1/TWSG1/IHH/THRA/PBX1/DDX39B 22 BP GO:0032570 response to progesterone 4/689 45/18670 0.08347 0.4671 0.4335 FOS/FOSB/THBS1/CATSPER3 4 BP GO:0045581 negative regulation of T cell differentiation 4/689 45/18670 0.08347 0.4671 0.4335 IRF1/PRDX2/IHH/LOXL3 4 BP GO:0048255 mRNA stabilization 4/689 45/18670 0.08347 0.4671 0.4335 DND1/ZFP36/PABPC1/BOLL 4 BP GO:1902743 regulation of lamellipodium organization 4/689 45/18670 0.08347 0.4671 0.4335 FSCN1/AUTS2/NCKAP1/VIL1 4 BP GO:0009743 response to carbohydrate 13/689 230/18670 0.08492 0.4736 0.4394 PTGS2/ICAM1/VAMP2/EGR1/GLUL/PHPT1/CDK16/THBS1/CCN2/CLEC7A/LEP/NR1D1/PRKCE 13 BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 10/689 165/18670 0.08534 0.4736 0.4394 PTGS2/PMAIP1/CLU/NCK2/FBXW7/MCL1/TAF9B/MSX1/ING2/BCL2L2 10 BP GO:0045787 positive regulation of cell cycle 20/689 389/18670 0.08572 0.4736 0.4394 BTG2/EGF/APP/ADAMTS1/PLK3/PLAGL1/PKD2/CDC14B/RAD23A/HES1/HMGN5/CCN2/ROCK2/MSX1/AIF1/PRKCE/RXFP3/RAB11A/PBX1/DDX39B 20 BP GO:0060041 retina development in camera-type eye 9/689 144/18670 0.08581 0.4736 0.4394 ARL6/ATOH7/MAX/JMJD6/ATP2B4/MDM1/CABP4/TGIF2/IHH 9 BP GO:0018212 peptidyl-tyrosine modification 19/689 366/18670 0.08584 0.4736 0.4394 EGF/OSM/ICAM1/APP/SOCS3/TESK2/PARP14/ACVR1/RIPK2/NCK2/PTK2/FBXW7/HES1/LEP/ROR1/PRKCE/ITGB3/ZAP70/IL15 19 BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 6/689 83/18670 0.08611 0.4736 0.4394 OSM/SOCS3/PARP14/HES1/LEP/IL15 6 BP GO:1901879 regulation of protein depolymerization 6/689 83/18670 0.08611 0.4736 0.4394 TMOD2/MAP1A/TAOK1/VIL1/MTPN/TTBK2 6 BP GO:0007229 integrin-mediated signaling pathway 7/689 103/18670 0.08654 0.4736 0.4394 ADAMTS1/PTK2/CEACAM1/CCN2/ITGB5/ITGB3/LOXL3 7 BP GO:0034766 negative regulation of ion transmembrane transport 7/689 103/18670 0.08654 0.4736 0.4394 SESTD1/PKD2/MIR26A1/THBS1/TLR9/BIN1/PRKCE 7 BP GO:1902106 negative regulation of leukocyte differentiation 7/689 103/18670 0.08654 0.4736 0.4394 IRF1/PRDX2/FBXW7/CEACAM1/IHH/TRIB1/LOXL3 7 BP GO:0048167 regulation of synaptic plasticity 11/689 187/18670 0.08663 0.4736 0.4394 PTGS2/EGR2/APP/VAMP2/YWHAH/MAP1A/NRGN/STAU1/SIPA1L1/HRAS/RAB11A 11 BP GO:0090068 positive regulation of cell cycle process 16/689 298/18670 0.08676 0.4736 0.4394 BTG2/EGF/APP/ADAMTS1/PLK3/PLAGL1/PKD2/CDC14B/CCN2/ROCK2/MSX1/AIF1/PRKCE/RXFP3/RAB11A/PBX1 16 BP GO:0002228 natural killer cell mediated immunity 5/689 64/18670 0.08701 0.4736 0.4394 NCR1/CEACAM1/LEP/KLRC2/SH2D1B 5 BP GO:0043550 regulation of lipid kinase activity 5/689 64/18670 0.08701 0.4736 0.4394 SOCS3/KLF4/PTK2/P2RY12/RUBCN 5 BP GO:0045600 positive regulation of fat cell differentiation 5/689 64/18670 0.08701 0.4736 0.4394 PTGS2/METRNL/ZFP36/KLF5/SAV1 5 BP GO:0051216 cartilage development 12/689 209/18670 0.08716 0.4736 0.4394 BMP8A/CTSK/PITX1/HOXB3/CCN2/BMP8B/BMP10/LEP/MSX1/IHH/MATN1/THRA 12 BP GO:0051701 interaction with host 12/689 209/18670 0.08716 0.4736 0.4394 UVRAG/CXCL8/ICAM1/TRIM26/ZNF502/ITGB5/CAV2/GUCY1A1/ITGB3/TRIM38/TNFRSF4/DDX39B 12 BP GO:0006470 protein dephosphorylation 17/689 321/18670 0.0873 0.4736 0.4394 PPP1R15A/DUSP1/PTPN7/PALD1/CDC14B/PHPT1/PPTC7/CTDSPL/SPPL3/ROCK2/PTP4A1/SMPD1/DAPP1/MASTL/CAMTA1/TAB1/PPP2R2D 17 BP GO:0071375 cellular response to peptide hormone stimulus 17/689 321/18670 0.0873 0.4736 0.4394 ATP6V0A2/NR4A2/STAT1/VAMP2/SOCS3/GPR21/ATP6V0E2/MAX/LEPROT/PTK2/CEACAM1/RAB31/ROCK2/APRT/LEP/CAV2/ATP6V1G2 17 BP GO:0016049 cell growth 24/689 484/18670 0.08829 0.4736 0.4394 SERTAD3/APP/OGFR/MUL1/GNG4/CTTN/AUTS2/FHL1/H3-3B/H3-5/LAMTOR1/GDF9/CEACAM1/BMP10/TAF9B/SGK1/MSX1/PDLIM5/MTPN/RTN4R/BLZF1/RAB11A/KIAA1109/DDX39B 24 BP GO:0002715 regulation of natural killer cell mediated immunity 4/689 46/18670 0.08889 0.4736 0.4394 NCR1/CEACAM1/LEP/SH2D1B 4 BP GO:0006984 ER-nucleus signaling pathway 4/689 46/18670 0.08889 0.4736 0.4394 PPP1R15A/CXCL8/NCK2/FBXW7 4 BP GO:0014075 response to amine 4/689 46/18670 0.08889 0.4736 0.4394 NR4A2/ICAM1/SLC18A2/CNR2 4 BP GO:0032369 negative regulation of lipid transport 4/689 46/18670 0.08889 0.4736 0.4394 EGF/MIR26A1/THBS1/ITGB3 4 BP GO:0043330 response to exogenous dsRNA 4/689 46/18670 0.08889 0.4736 0.4394 IFIH1/MUL1/DDX58/RIPK2 4 BP GO:0045776 negative regulation of blood pressure 4/689 46/18670 0.08889 0.4736 0.4394 GCH1/ADRB3/RNLS/NOS3 4 BP GO:0048512 circadian behavior 4/689 46/18670 0.08889 0.4736 0.4394 PTGDS/EGR1/PER3/NR1D1 4 BP GO:0050706 regulation of interleukin-1 beta secretion 4/689 46/18670 0.08889 0.4736 0.4394 TNFAIP3/RIPK2/ARG2/PANX1 4 BP GO:0060711 labyrinthine layer development 4/689 46/18670 0.08889 0.4736 0.4394 SOCS3/JUNB/HES1/SPINT2 4 BP GO:0097720 calcineurin-mediated signaling 4/689 46/18670 0.08889 0.4736 0.4394 ATP2B4/SPPL3/LMCD1/CAMTA1 4 BP GO:0001667 ameboidal-type cell migration 23/689 461/18670 0.08908 0.4736 0.4394 PTGS2/EGR3/GLUL/ACVR1/KLF4/PTK2/FBXW7/CEACAM1/MIR26A1/THBS1/P2RY12/ROCK2/BMP10/MIR129-1/VIL1/AGO2/PRKCE/ITGB3/RAB11A/NOS3/PLEKHG5/MIR22/ZNF580 23 BP GO:0018209 peptidyl-serine modification 17/689 322/18670 0.08918 0.4736 0.4394 PTGS2/RAMP3/OSM/APP/NLK/RIPK2/NCK2/TBK1/OPRD1/ATP2B4/ROCK2/TSSK6/SGK1/MASTL/PRKCE/TTBK2/PLK1 17 BP GO:0007163 establishment or maintenance of cell polarity 12/689 210/18670 0.08953 0.4736 0.4394 FSCN1/MOS/PARD3/MPP7/PTK2/CLIC4/HES1/ROCK2/SPINT2/PLK1/PARD6B/SAPCD2 12 BP GO:0048871 multicellular organismal homeostasis 24/689 485/18670 0.08982 0.4736 0.4394 G0S2/PTGS2/GCNT2/BMP8A/EGR1/METRNL/TNFAIP3/CTSK/LEPR/PM20D1/TLR9/CCN2/MDM1/ADRB3/LEP/NR1D1/IQCB1/ITGB3/IHH/RAB11A/NOS3/IL15/THRA/CDH23 24 BP GO:0010507 negative regulation of autophagy 6/689 84/18670 0.09001 0.4736 0.4394 LEPR/PTK2/RASIP1/MCL1/RUBCN/LEP 6 BP GO:0006892 post-Golgi vesicle-mediated transport 7/689 104/18670 0.09001 0.4736 0.4394 VAMP2/VTI1B/ANKFY1/RABIF/RAB31/BLZF1/EHD3 7 BP GO:0014812 muscle cell migration 7/689 104/18670 0.09001 0.4736 0.4394 TPM1/ADAMTS1/PLEKHO1/MIR26A1/AIF1/ITGB3/TRIB1 7 BP GO:0000303 response to superoxide 3/689 29/18670 0.09002 0.4736 0.4394 GCH1/PRDX2/NOS3 3 BP GO:0015949 nucleobase-containing small molecule interconversion 3/689 29/18670 0.09002 0.4736 0.4394 GMPR/NME4/AK9 3 BP GO:0021602 cranial nerve morphogenesis 3/689 29/18670 0.09002 0.4736 0.4394 EGR2/HOXB3/HOXA1 3 BP GO:0031114 regulation of microtubule depolymerization 3/689 29/18670 0.09002 0.4736 0.4394 MAP1A/TAOK1/TTBK2 3 BP GO:0042226 interleukin-6 biosynthetic process 3/689 29/18670 0.09002 0.4736 0.4394 APP/MIR26A1/CLEC7A 3 BP GO:0044788 modulation by host of viral process 3/689 29/18670 0.09002 0.4736 0.4394 ZNF502/CAV2/STOM 3 BP GO:0046134 pyrimidine nucleoside biosynthetic process 3/689 29/18670 0.09002 0.4736 0.4394 NME4/NME7/UCK2 3 BP GO:0072538 T-helper 17 type immune response 3/689 29/18670 0.09002 0.4736 0.4394 NFKBIZ/LOXL3/BATF 3 BP GO:1900027 regulation of ruffle assembly 3/689 29/18670 0.09002 0.4736 0.4394 ICAM1/P2RY12/HRAS 3 BP GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3/689 29/18670 0.09002 0.4736 0.4394 ARG2/TWSG1/LOXL3 3 BP GO:0006164 purine nucleotide biosynthetic process 16/689 300/18670 0.09068 0.4736 0.4394 PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/PGK1/APRT/ADPGK/GUCY1A1/NME7/NOS3/AK9 16 BP GO:0046390 ribose phosphate biosynthetic process 16/689 300/18670 0.09068 0.4736 0.4394 PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/PGK1/APRT/ADPGK/GUCY1A1/NME7/AK9/UCK2 16 BP GO:0070372 regulation of ERK1 and ERK2 cascade 16/689 300/18670 0.09068 0.4736 0.4394 DUSP1/RAMP3/GBP1/ICAM1/APP/GCNT2/RIPK2/KLF4/CCL7/FBXW7/CEACAM1/C3orf33/CCN2/HRAS/SIRT3/BTN2A2 16 BP GO:0045471 response to ethanol 8/689 125/18670 0.09154 0.4736 0.4394 ICAM1/POLB/OGG1/CCL7/ITPR2/LEP/PRKCE/SDF4 8 BP GO:0006940 regulation of smooth muscle contraction 5/689 65/18670 0.09156 0.4736 0.4394 PTGS2/ADRA1B/CTTN/SPX/GUCY1A1 5 BP GO:0032729 positive regulation of interferon-gamma production 5/689 65/18670 0.09156 0.4736 0.4394 PDE4B/RIPK2/TLR9/HRAS/CLEC7A 5 BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 5/689 65/18670 0.09156 0.4736 0.4394 GBP1/PHPT1/GCSAM/CEACAM1/BTN2A2 5 BP GO:0072665 protein localization to vacuole 5/689 65/18670 0.09156 0.4736 0.4394 GBP1/TNFAIP3/VTI1B/CLU/ROCK2 5 BP GO:1904892 regulation of STAT cascade 9/689 146/18670 0.09159 0.4736 0.4394 EGF/OSM/SOCS3/NLK/PARP14/LEPROT/HES1/LEP/IL15 9 BP GO:1903531 negative regulation of secretion by cell 12/689 211/18670 0.09193 0.4736 0.4394 GBP1/OSM/BMP8A/TNFAIP3/ARG2/RHBDF2/CEACAM1/P2RY12/LEP/SYTL4/TNFRSF4/BTN2A2 12 BP GO:0001558 regulation of cell growth 21/689 416/18670 0.09205 0.4736 0.4394 SERTAD3/OGFR/MUL1/GNG4/CTTN/FHL1/H3-3B/H3-5/LAMTOR1/GDF9/CEACAM1/BMP10/TAF9B/SGK1/MSX1/MTPN/RTN4R/BLZF1/RAB11A/KIAA1109/DDX39B 21 BP GO:0006244 pyrimidine nucleotide catabolic process 2/689 14/18670 0.09234 0.4736 0.4394 OGG1/DCTPP1 2 BP GO:0009214 cyclic nucleotide catabolic process 2/689 14/18670 0.09234 0.4736 0.4394 PDE4B/PDE5A 2 BP GO:0015780 nucleotide-sugar transmembrane transport 2/689 14/18670 0.09234 0.4736 0.4394 SLC35D2/SLC35E2A 2 BP GO:0021535 cell migration in hindbrain 2/689 14/18670 0.09234 0.4736 0.4394 TTBK2/RBFOX2 2 BP GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 2/689 14/18670 0.09234 0.4736 0.4394 PTGS2/RNLS 2 BP GO:0043173 nucleotide salvage 2/689 14/18670 0.09234 0.4736 0.4394 APRT/UCK2 2 BP GO:0043558 regulation of translational initiation in response to stress 2/689 14/18670 0.09234 0.4736 0.4394 PPP1R15A/NCK2 2 BP GO:0046033 AMP metabolic process 2/689 14/18670 0.09234 0.4736 0.4394 APRT/AK9 2 BP GO:0046341 CDP-diacylglycerol metabolic process 2/689 14/18670 0.09234 0.4736 0.4394 GPAM/AGPAT1 2 BP GO:0048308 organelle inheritance 2/689 14/18670 0.09234 0.4736 0.4394 PLK3/VCPIP1 2 BP GO:0048313 Golgi inheritance 2/689 14/18670 0.09234 0.4736 0.4394 PLK3/VCPIP1 2 BP GO:0050720 interleukin-1 beta biosynthetic process 2/689 14/18670 0.09234 0.4736 0.4394 APP/EGR1 2 BP GO:0051645 Golgi localization 2/689 14/18670 0.09234 0.4736 0.4394 UVRAG/ARHGAP21 2 BP GO:0051917 regulation of fibrinolysis 2/689 14/18670 0.09234 0.4736 0.4394 PLG/THBS1 2 BP GO:0060049 regulation of protein glycosylation 2/689 14/18670 0.09234 0.4736 0.4394 POMT1/IL15 2 BP GO:0072425 signal transduction involved in G2 DNA damage checkpoint 2/689 14/18670 0.09234 0.4736 0.4394 CDC14B/PLK1 2 BP GO:1901070 guanosine-containing compound biosynthetic process 2/689 14/18670 0.09234 0.4736 0.4394 NME4/NME7 2 BP GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 2/689 14/18670 0.09234 0.4736 0.4394 ACVR1/MSX1 2 BP GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/689 14/18670 0.09234 0.4736 0.4394 PMAIP1/THBS1 2 BP GO:1902656 calcium ion import into cytosol 2/689 14/18670 0.09234 0.4736 0.4394 RAMP3/ATP2B4 2 BP GO:0036293 response to decreased oxygen levels 19/689 370/18670 0.09292 0.476 0.4417 PTGS2/PMAIP1/NR4A2/SLC2A1/ICAM1/PLK3/EGR1/PDLIM1/PLOD2/CHCHD2/OPRD1/PGK1/THBS1/CCN2/ROCK2/MPL/ITPR2/LEP/PRKCE 19 BP GO:0071248 cellular response to metal ion 11/689 190/18670 0.09426 0.4814 0.4467 PTGS2/FOS/APP/JUNB/PKD2/JUND/MT1G/OGG1/AKR1C3/CLIC4/FOSB 11 BP GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 4/689 47/18670 0.09447 0.4814 0.4467 NFKBIZ/RIPK2/CD83/LOXL3 4 BP GO:0045058 T cell selection 4/689 47/18670 0.09447 0.4814 0.4467 ZAP70/LOXL3/IL15/BATF 4 BP GO:0045646 regulation of erythrocyte differentiation 4/689 47/18670 0.09447 0.4814 0.4467 STAT1/ZFP36/SMAP1/RBFOX2 4 BP GO:0050435 amyloid-beta metabolic process 4/689 47/18670 0.09447 0.4814 0.4467 APP/CLU/ROCK2/BIN1 4 BP GO:1901657 glycosyl compound metabolic process 9/689 147/18670 0.09457 0.4814 0.4467 NT5C3A/AKR1C3/NME4/TJP2/PRTFDC1/LCMT2/APRT/NME7/UCK2 9 BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/689 126/18670 0.09478 0.482 0.4472 VEPH1/ACVR1/RBPMS2/ONECUT2/RASL11B/MIR26A1/CAV2/TWSG1 8 BP GO:0048207 vesicle targeting, rough ER to cis-Golgi 5/689 66/18670 0.09623 0.4869 0.4518 NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 5 BP GO:0048208 COPII vesicle coating 5/689 66/18670 0.09623 0.4869 0.4518 NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 5 BP GO:1901607 alpha-amino acid biosynthetic process 5/689 66/18670 0.09623 0.4869 0.4518 GLUL/PSAT1/PLOD2/ATP2B4/SEPHS1 5 BP GO:1901880 negative regulation of protein depolymerization 5/689 66/18670 0.09623 0.4869 0.4518 TMOD2/TAOK1/VIL1/MTPN/TTBK2 5 BP GO:0009152 purine ribonucleotide biosynthetic process 15/689 280/18670 0.09627 0.4869 0.4518 PPCDC/ELOVL4/APP/DNAJC30/GUCY1B1/PRKAG2/SCD5/NUP188/NME4/PGK1/APRT/ADPGK/GUCY1A1/NME7/AK9 15 BP GO:0006333 chromatin assembly or disassembly 11/689 191/18670 0.09689 0.4876 0.4524 HIRIP3/NAP1L5/CENPC/TSPYL5/H3-3B/CENPS/H2BU1/HMGA1/H4C8/H2AW/SMCHD1 11 BP GO:0000305 response to oxygen radical 3/689 30/18670 0.09741 0.4876 0.4524 GCH1/PRDX2/NOS3 3 BP GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 3/689 30/18670 0.09741 0.4876 0.4524 NFKBIZ/RIPK2/CD83 3 BP GO:0061157 mRNA destabilization 3/689 30/18670 0.09741 0.4876 0.4524 ZFP36/ROCK2/MOV10 3 BP GO:0071480 cellular response to gamma radiation 3/689 30/18670 0.09741 0.4876 0.4524 EGR1/TSPYL5/HRAS 3 BP GO:0090200 positive regulation of release of cytochrome c from mitochondria 3/689 30/18670 0.09741 0.4876 0.4524 PMAIP1/CHCHD10/PDCD5 3 BP GO:1902751 positive regulation of cell cycle G2/M phase transition 3/689 30/18670 0.09741 0.4876 0.4524 APP/RAB11A/PBX1 3 BP GO:1904893 negative regulation of STAT cascade 3/689 30/18670 0.09741 0.4876 0.4524 SOCS3/PARP14/LEPROT 3 BP GO:1905144 response to acetylcholine 3/689 30/18670 0.09741 0.4876 0.4524 ATP2B4/ROCK2/CHRM5 3 BP GO:1905145 cellular response to acetylcholine 3/689 30/18670 0.09741 0.4876 0.4524 ATP2B4/ROCK2/CHRM5 3 BP GO:0002792 negative regulation of peptide secretion 9/689 148/18670 0.09759 0.488 0.4528 GBP1/BMP8A/TNFAIP3/ARG2/RHBDF2/LEP/SYTL4/TNFRSF4/BTN2A2 9 BP GO:0006303 double-strand break repair via nonhomologous end joining 6/689 86/18670 0.09808 0.4884 0.4532 UVRAG/NBN/POLB/MDC1/H4C8/SMCHD1 6 BP GO:0007260 tyrosine phosphorylation of STAT protein 6/689 86/18670 0.09808 0.4884 0.4532 OSM/SOCS3/PARP14/HES1/LEP/IL15 6 BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 6/689 86/18670 0.09808 0.4884 0.4532 PMAIP1/ICAM1/TNFAIP3/FAIM/THBS1/NOS3 6 BP GO:0042058 regulation of epidermal growth factor receptor signaling pathway 6/689 86/18670 0.09808 0.4884 0.4532 EGF/APP/NCK2/RHBDF2/FBXW7/CEACAM1 6 BP GO:0045732 positive regulation of protein catabolic process 12/689 214/18670 0.09937 0.4898 0.4545 EGF/NUB1/PLK3/TNFAIP3/CLU/ZFAND2A/RAD23A/PTK2/FBXW7/RNF19B/PLK1/TRIB1 12 BP GO:0043112 receptor metabolic process 11/689 192/18670 0.09956 0.4898 0.4545 RAMP3/UVRAG/CXCL8/EGF/LAMTOR1/CEACAM1/RAB31/ANKRD13B/NR1D1/ITGB3/EHD3 11 BP GO:0001774 microglial cell activation 4/689 48/18670 0.1002 0.4898 0.4545 APP/CLU/NR1D1/AIF1 4 BP GO:0002269 leukocyte activation involved in inflammatory response 4/689 48/18670 0.1002 0.4898 0.4545 APP/CLU/NR1D1/AIF1 4 BP GO:0007140 male meiotic nuclear division 4/689 48/18670 0.1002 0.4898 0.4545 TDRKH/DMC1/REC8/ING2 4 BP GO:0031055 chromatin remodeling at centromere 4/689 48/18670 0.1002 0.4898 0.4545 CENPC/H3-3B/CENPS/H4C8 4 BP GO:0046850 regulation of bone remodeling 4/689 48/18670 0.1002 0.4898 0.4545 TNFAIP3/LEPR/LEP/ITGB3 4 BP GO:0090199 regulation of release of cytochrome c from mitochondria 4/689 48/18670 0.1002 0.4898 0.4545 PMAIP1/CLU/CHCHD10/PDCD5 4 BP GO:0042326 negative regulation of phosphorylation 23/689 468/18670 0.1005 0.4898 0.4545 DUSP1/GBP1/SOCS3/NPRL2/PRKAG2/TNFAIP3/PARP14/PARD3/LAX1/NCK2/KLF4/CEACAM1/C3orf33/CTDSPL/MIR26A1/RASIP1/SMPD1/RUBCN/DTNBP1/SIRT3/PLK1/TRIB1/BTN2A2 23 BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 9/689 149/18670 0.1007 0.4898 0.4545 TMOD2/RAMP3/MGLL/CXCL8/GNG4/ATP2B4/ROCK2/DTNBP1/CAV2 9 BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 7/689 107/18670 0.1009 0.4898 0.4545 PMAIP1/BTG2/NBN/PLK3/PLAGL1/MSX1/BATF 7 BP GO:0051341 regulation of oxidoreductase activity 7/689 107/18670 0.1009 0.4898 0.4545 GCH1/CHCHD10/MIR26A1/ATP2B4/CNR2/LEP/NOS3 7 BP GO:0003143 embryonic heart tube morphogenesis 5/689 67/18670 0.101 0.4898 0.4545 PKD2/ACVR1/HES1/NOTO/IHH 5 BP GO:0048747 muscle fiber development 5/689 67/18670 0.101 0.4898 0.4545 MYOM1/SELENON/XK/CAV2/MYOF 5 BP GO:1903391 regulation of adherens junction organization 5/689 67/18670 0.101 0.4898 0.4545 PHLDB2/SLK/PTK2/THBS1/ROCK2 5 BP GO:0031669 cellular response to nutrient levels 13/689 237/18670 0.1011 0.4898 0.4545 PTGS2/PMAIP1/SLC2A1/ICAM1/NPRL2/MAX/KLF10/GLUL/AKR1C3/CASTOR1/P2RY12/LEP/IL15 13 BP GO:0034763 negative regulation of transmembrane transport 8/689 128/18670 0.1014 0.4898 0.4545 SESTD1/PKD2/MIR26A1/THBS1/TLR9/LEP/BIN1/PRKCE 8 BP GO:0000910 cytokinesis 10/689 171/18670 0.1019 0.4898 0.4545 UVRAG/PLK3/KLHDC8B/CDC14B/ROCK2/PRPF40A/PRKCE/RXFP3/RAB11A/PLK1 10 BP GO:0032412 regulation of ion transmembrane transporter activity 14/689 260/18670 0.1022 0.4898 0.4545 PDE4B/APP/VAMP2/PKD2/CNIH3/YWHAH/FHL1/CHCHD10/SELENON/MIR26A1/TLR9/STOM/PRKCE/EHD3 14 BP GO:0072659 protein localization to plasma membrane 14/689 260/18670 0.1022 0.4898 0.4545 RAMP3/GBP1/ARL6/VAMP2/TSPAN33/VTI1B/RAB31/ROCK2/CNPY4/VIL1/BLZF1/PRKCE/EHD3/RAB11A 14 BP GO:1901654 response to ketone 11/689 193/18670 0.1023 0.4898 0.4545 DUSP1/FOS/XRN1/ICAM1/AKR1C3/KLF4/FOSB/THBS1/ROCK2/CATSPER3/PRKCE 11 BP GO:0043062 extracellular structure organization 21/689 422/18670 0.1026 0.4898 0.4545 PHLDB2/ICAM1/APP/FBLN2/FSCN1/CAPNS2/CTSK/PLG/PLOD2/PTK2/ICAM4/THBS1/CCN2/POMT1/ITGB5/ADAMTSL4/SPINT2/ITGB3/IHH/MATN1/LOXL3 21 BP GO:0008203 cholesterol metabolic process 9/689 150/18670 0.1038 0.4898 0.4545 APP/APOL1/MVK/CYP7B1/LEPR/GPAM/SNX17/SMPD1/LEP 9 BP GO:0050777 negative regulation of immune response 9/689 150/18670 0.1038 0.4898 0.4545 TNFAIP3/MUL1/PARP14/TRAFD1/ARG2/SERPING1/CEACAM1/FCRLB/LOXL3 9 BP GO:0071774 response to fibroblast growth factor 9/689 150/18670 0.1038 0.4898 0.4545 EGR3/CXCL8/GTF2F2/ZFP36/FGFBP3/THBS1/CCN2/SETX/RBFOX2 9 BP GO:0001829 trophectodermal cell differentiation 2/689 15/18670 0.104 0.4898 0.4545 HOPX/JUNB 2 BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 2/689 15/18670 0.104 0.4898 0.4545 TAP2/TAP1 2 BP GO:0009415 response to water 2/689 15/18670 0.104 0.4898 0.4545 PKD2/ATP2B4 2 BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 2/689 15/18670 0.104 0.4898 0.4545 TAP2/TAP1 2 BP GO:0030852 regulation of granulocyte differentiation 2/689 15/18670 0.104 0.4898 0.4545 CEACAM1/TRIB1 2 BP GO:0032105 negative regulation of response to extracellular stimulus 2/689 15/18670 0.104 0.4898 0.4545 SPX/LEP 2 BP GO:0032108 negative regulation of response to nutrient levels 2/689 15/18670 0.104 0.4898 0.4545 SPX/LEP 2 BP GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 2/689 15/18670 0.104 0.4898 0.4545 DDX58/TLR9 2 BP GO:0034134 toll-like receptor 2 signaling pathway 2/689 15/18670 0.104 0.4898 0.4545 TNFAIP3/RIPK2 2 BP GO:0042559 pteridine-containing compound biosynthetic process 2/689 15/18670 0.104 0.4898 0.4545 GCH1/PTS 2 BP GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 2/689 15/18670 0.104 0.4898 0.4545 PMAIP1/MSX1 2 BP GO:0043584 nose development 2/689 15/18670 0.104 0.4898 0.4545 GNG8/SMCHD1 2 BP GO:0045360 regulation of interleukin-1 biosynthetic process 2/689 15/18670 0.104 0.4898 0.4545 APP/EGR1 2 BP GO:0045410 positive regulation of interleukin-6 biosynthetic process 2/689 15/18670 0.104 0.4898 0.4545 APP/CLEC7A 2 BP GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 2/689 15/18670 0.104 0.4898 0.4545 STAT1/TLR9 2 BP GO:0060579 ventral spinal cord interneuron fate commitment 2/689 15/18670 0.104 0.4898 0.4545 NKX6-2/EVX1 2 BP GO:0060581 cell fate commitment involved in pattern specification 2/689 15/18670 0.104 0.4898 0.4545 NKX6-2/EVX1 2 BP GO:0070571 negative regulation of neuron projection regeneration 2/689 15/18670 0.104 0.4898 0.4545 RTN4RL1/RTN4R 2 BP GO:0072075 metanephric mesenchyme development 2/689 15/18670 0.104 0.4898 0.4545 STAT1/PKD2 2 BP GO:0090136 epithelial cell-cell adhesion 2/689 15/18670 0.104 0.4898 0.4545 ITGB5/IHH 2 BP GO:0090197 positive regulation of chemokine secretion 2/689 15/18670 0.104 0.4898 0.4545 C5/AIF1 2 BP GO:1900029 positive regulation of ruffle assembly 2/689 15/18670 0.104 0.4898 0.4545 P2RY12/HRAS 2 BP GO:1900037 regulation of cellular response to hypoxia 2/689 15/18670 0.104 0.4898 0.4545 CHCHD2/ROCK2 2 BP GO:1902188 positive regulation of viral release from host cell 2/689 15/18670 0.104 0.4898 0.4545 ZNF502/CAV2 2 BP GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 2/689 15/18670 0.104 0.4898 0.4545 SESTD1/BIN1 2 BP GO:1903358 regulation of Golgi organization 2/689 15/18670 0.104 0.4898 0.4545 USP6NL/EHD3 2 BP GO:0000075 cell cycle checkpoint 12/689 216/18670 0.1045 0.4898 0.4545 DUSP1/BTG2/NBN/PLK3/PLAGL1/CDC14B/MDC1/RNASEH2B/HRAS/TAOK1/PLK1/DDX39B 12 BP GO:0032869 cellular response to insulin stimulus 12/689 216/18670 0.1045 0.4898 0.4545 ATP6V0A2/STAT1/VAMP2/SOCS3/GPR21/ATP6V0E2/CEACAM1/RAB31/APRT/LEP/CAV2/ATP6V1G2 12 BP GO:0002675 positive regulation of acute inflammatory response 3/689 31/18670 0.105 0.4898 0.4545 PTGS2/OSM/C2CD4A 3 BP GO:0009394 2'-deoxyribonucleotide metabolic process 3/689 31/18670 0.105 0.4898 0.4545 OGG1/DCTPP1/AK9 3 BP GO:0010543 regulation of platelet activation 3/689 31/18670 0.105 0.4898 0.4545 CEACAM1/SELP/NOS3 3 BP GO:0030431 sleep 3/689 31/18670 0.105 0.4898 0.4545 FOS/PTGDS/PER3 3 BP GO:0033198 response to ATP 3/689 31/18670 0.105 0.4898 0.4545 PTGS2/PANX1/P2RY12 3 BP GO:0035767 endothelial cell chemotaxis 3/689 31/18670 0.105 0.4898 0.4545 EGR3/THBS1/PLEKHG5 3 BP GO:0040020 regulation of meiotic nuclear division 3/689 31/18670 0.105 0.4898 0.4545 PDE3A/MOS/MSX1 3 BP GO:0048710 regulation of astrocyte differentiation 3/689 31/18670 0.105 0.4898 0.4545 HES1/NR1D1/BIN1 3 BP GO:0090075 relaxation of muscle 3/689 31/18670 0.105 0.4898 0.4545 PDE4B/GUCY1A1/PDE5A 3 BP GO:1902186 regulation of viral release from host cell 3/689 31/18670 0.105 0.4898 0.4545 TRIM26/ZNF502/CAV2 3 BP GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/689 31/18670 0.105 0.4898 0.4545 CLU/TAF9B/ING2 3 BP GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/689 31/18670 0.105 0.4898 0.4545 TAF9B/MSX1/ING2 3 BP GO:0031647 regulation of protein stability 15/689 284/18670 0.1051 0.4898 0.4545 NLK/MUL1/CLU/RAD23A/HYPK/FBXW7/USP25/PIM2/TAF9B/MSX1/PER3/NR1D1/PLK1/SAV1/CPN2 15 BP GO:0010812 negative regulation of cell-substrate adhesion 5/689 68/18670 0.1059 0.4911 0.4557 PHLDB2/GBP1/GCNT2/PLG/THBS1 5 BP GO:0016239 positive regulation of macroautophagy 5/689 68/18670 0.1059 0.4911 0.4557 UVRAG/RIPK2/TBK1/PIM2/CALCOCO2 5 BP GO:0033627 cell adhesion mediated by integrin 5/689 68/18670 0.1059 0.4911 0.4557 ICAM1/PTK2/P2RY12/ITGB5/ITGB3 5 BP GO:0002686 negative regulation of leukocyte migration 4/689 49/18670 0.1061 0.4911 0.4557 DUSP1/C5/GCSAM/CCL28 4 BP GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 4/689 49/18670 0.1061 0.4911 0.4557 TPM1/ADRA1B/ADRB3/NOS3 4 BP GO:0032757 positive regulation of interleukin-8 production 4/689 49/18670 0.1061 0.4911 0.4557 DDX58/TLR9/CLEC7A/ZNF580 4 BP GO:0051445 regulation of meiotic cell cycle 4/689 49/18670 0.1061 0.4911 0.4557 DUSP1/PDE3A/MOS/MSX1 4 BP GO:0032088 negative regulation of NF-kappaB transcription factor activity 6/689 88/18670 0.1065 0.4915 0.4561 TRAF3/TNFAIP3/PRDX2/KLF4/PELI1/TLR9 6 BP GO:0043506 regulation of JUN kinase activity 6/689 88/18670 0.1065 0.4915 0.4561 MAP4K2/MUL1/RIPK2/TLR9/TAOK1/DTNBP1 6 BP GO:1903725 regulation of phospholipid metabolic process 6/689 88/18670 0.1065 0.4915 0.4561 SOCS3/KLF4/PTK2/P2RY12/RUBCN/CHRM5 6 BP GO:0001505 regulation of neurotransmitter levels 18/689 354/18670 0.1068 0.4921 0.4566 PTGS2/GCH1/ICAM1/VAMP2/NAPA/PKD2/SLC18A2/GLUL/ARG2/CLU/KLF4/ATP2B4/ROCK2/CLEC7A/DTNBP1/AIF1/ITGB3/NOS3 18 BP GO:0009314 response to radiation 22/689 448/18670 0.107 0.4921 0.4566 PTGS2/DUSP1/FOS/ELOVL4/ICAM1/APP/JUNB/PLK3/EGR1/JUND/POLB/OGG1/C9orf116/TSPYL5/XRRA1/CCL7/CABP4/HRAS/PER3/SDF4/HOXA1/H2AW 22 BP GO:1903169 regulation of calcium ion transmembrane transport 9/689 151/18670 0.107 0.4921 0.4566 SESTD1/RAMP3/PDE4B/PKD2/SELENON/TLR9/BIN1/PRKCE/EHD3 9 BP GO:0008406 gonad development 12/689 217/18670 0.1072 0.4921 0.4566 ICAM1/ADAMTS1/AKR1C3/H3-3B/GDF9/DMC1/REC8/LEP/NRIP1/ING2/NOS3/BCL2L2 12 BP GO:0071241 cellular response to inorganic substance 12/689 217/18670 0.1072 0.4921 0.4566 PTGS2/FOS/APP/JUNB/PKD2/GUCY1B1/JUND/MT1G/OGG1/AKR1C3/CLIC4/FOSB 12 BP GO:0051348 negative regulation of transferase activity 15/689 285/18670 0.1074 0.4928 0.4572 DUSP1/SOCS3/NPRL2/PRKAG2/TNFAIP3/ZFP36/LAX1/PHPT1/CEACAM1/RASIP1/SMPD1/RUBCN/DTNBP1/PLK1/TRIB1 15 BP GO:0055002 striated muscle cell development 10/689 173/18670 0.1079 0.4944 0.4588 TPM1/TMOD2/MYOM1/SELENON/XK/BMP10/CAV2/PDLIM5/MYOF/DDX39B 10 BP GO:0003231 cardiac ventricle development 8/689 130/18670 0.1084 0.4957 0.46 TPM1/ACVR1/HES1/BMP10/TMEM65/DCTN5/NOS3/SAV1 8 BP GO:0008033 tRNA processing 8/689 130/18670 0.1084 0.4957 0.46 METTL2A/METTL2B/FTSJ1/ADAT1/LCMT2/TP53RK/SEPHS1/TSEN54 8 BP GO:0010001 glial cell differentiation 12/689 218/18670 0.1098 0.502 0.4658 EGR2/APP/NKX6-2/METRN/PARD3/CLU/HES1/MIR26A1/ROR1/NR1D1/WASF3/BIN1 12 BP GO:0006694 steroid biosynthetic process 11/689 196/18670 0.1107 0.5053 0.4689 PRKAG2/EGR1/MVK/CYP7B1/AKR1C3/GPAM/FAXDC2/DHRS11/LEP/NR1D1/PBX1 11 BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 6/689 89/18670 0.1109 0.5053 0.4689 GNAZ/CORT/OPRD1/P2RY12/CHRM5/OR56A1 6 BP GO:0046427 positive regulation of JAK-STAT cascade 6/689 89/18670 0.1109 0.5053 0.4689 OSM/SOCS3/PARP14/HES1/LEP/IL15 6 BP GO:0002931 response to ischemia 4/689 50/18670 0.1122 0.5064 0.4699 EGR1/PANX1/ROCK2/RNLS 4 BP GO:0009409 response to cold 4/689 50/18670 0.1122 0.5064 0.4699 FOS/GMPR/METRNL/THRA 4 BP GO:0010171 body morphogenesis 4/689 50/18670 0.1122 0.5064 0.4699 PHLDB2/CSRNP1/MSX1/IHH 4 BP GO:0043489 RNA stabilization 4/689 50/18670 0.1122 0.5064 0.4699 DND1/ZFP36/PABPC1/BOLL 4 BP GO:0033559 unsaturated fatty acid metabolic process 7/689 110/18670 0.1124 0.5064 0.4699 PTGS2/PTGDS/MGLL/ELOVL4/SCD5/AKR1C3/PTGS1 7 BP GO:0007584 response to nutrient 12/689 219/18670 0.1126 0.5064 0.4699 PTGS2/STAT1/OGG1/PANX1/AKR1C3/CASTOR1/SERPINC1/P2RY12/LEP/TSHB/IL15/CCL28 12 BP GO:0001569 branching involved in blood vessel morphogenesis 3/689 32/18670 0.1129 0.5064 0.4699 ACVR1/GNA13/IHH 3 BP GO:0003338 metanephros morphogenesis 3/689 32/18670 0.1129 0.5064 0.4699 STAT1/PKD2/HES1 3 BP GO:0045907 positive regulation of vasoconstriction 3/689 32/18670 0.1129 0.5064 0.4699 PTGS2/ICAM1/ADRA1B 3 BP GO:0048741 skeletal muscle fiber development 3/689 32/18670 0.1129 0.5064 0.4699 SELENON/XK/CAV2 3 BP GO:0050779 RNA destabilization 3/689 32/18670 0.1129 0.5064 0.4699 ZFP36/ROCK2/MOV10 3 BP GO:0051385 response to mineralocorticoid 3/689 32/18670 0.1129 0.5064 0.4699 FOS/FOSB/CCN2 3 BP GO:0070570 regulation of neuron projection regeneration 3/689 32/18670 0.1129 0.5064 0.4699 RTN4RL1/KLF4/RTN4R 3 BP GO:1901976 regulation of cell cycle checkpoint 3/689 32/18670 0.1129 0.5064 0.4699 DUSP1/RNASEH2B/DDX39B 3 BP GO:2000780 negative regulation of double-strand break repair 3/689 32/18670 0.1129 0.5064 0.4699 OGG1/RNF169/SMCHD1 3 BP GO:0050729 positive regulation of inflammatory response 9/689 153/18670 0.1136 0.5064 0.4699 PTGS2/OSM/NFKBIZ/GBP5/TLR9/CLEC7A/C2CD4A/IL15/MIR22 9 BP GO:0002793 positive regulation of peptide secretion 15/689 288/18670 0.1145 0.5064 0.4699 OSM/MYOM1/IFIH1/DDX58/GLUL/RIPK2/PANX1/PHPT1/C5/C1QTNF4/SYTL4/AIF1/SIRT3/PRKCE/TNFRSF4 15 BP GO:0002526 acute inflammatory response 12/689 220/18670 0.1153 0.5064 0.4699 PTGS2/OSM/ICAM1/OGG1/ACVR1/SERPING1/CLU/C5/SERPINC1/C2CD4A/SIGIRR/CPN2 12 BP GO:0015844 monoamine transport 6/689 90/18670 0.1153 0.5064 0.4699 SLC18A2/P2RY12/DTNBP1/ITGB3/CHRM5/OR56A1 6 BP GO:0045132 meiotic chromosome segregation 6/689 90/18670 0.1153 0.5064 0.4699 MOS/CENPC/CENPS/DMC1/REC8/PLK1 6 BP GO:0046849 bone remodeling 6/689 90/18670 0.1153 0.5064 0.4699 TNFAIP3/CTSK/LEPR/LEP/ITGB3/IHH 6 BP GO:0042552 myelination 8/689 132/18670 0.1155 0.5064 0.4699 EGR2/NKX6-2/PARD3/CLU/MIR26A1/GJC3/XK/WASF3 8 BP GO:0045598 regulation of fat cell differentiation 8/689 132/18670 0.1155 0.5064 0.4699 PTGS2/METRNL/ZFP36/HES1/LEP/NR1D1/KLF5/SAV1 8 BP GO:0001933 negative regulation of protein phosphorylation 21/689 429/18670 0.1158 0.5064 0.4699 DUSP1/GBP1/SOCS3/PRKAG2/TNFAIP3/PARP14/PARD3/LAX1/NCK2/KLF4/CEACAM1/C3orf33/CTDSPL/MIR26A1/RASIP1/SMPD1/DTNBP1/SIRT3/PLK1/TRIB1/BTN2A2 21 BP GO:0006901 vesicle coating 5/689 70/18670 0.1161 0.5064 0.4699 NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 5 BP GO:0001780 neutrophil homeostasis 2/689 16/18670 0.1161 0.5064 0.4699 PDE4B/MPL 2 BP GO:0002295 T-helper cell lineage commitment 2/689 16/18670 0.1161 0.5064 0.4699 LOXL3/BATF 2 BP GO:0006837 serotonin transport 2/689 16/18670 0.1161 0.5064 0.4699 SLC18A2/ITGB3 2 BP GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 2/689 16/18670 0.1161 0.5064 0.4699 KLF4/BTN2A2 2 BP GO:0022038 corpus callosum development 2/689 16/18670 0.1161 0.5064 0.4699 RTN4RL1/RTN4R 2 BP GO:0030033 microvillus assembly 2/689 16/18670 0.1161 0.5064 0.4699 FSCN1/KLF5 2 BP GO:0032604 granulocyte macrophage colony-stimulating factor production 2/689 16/18670 0.1161 0.5064 0.4699 DDX58/TLR9 2 BP GO:0035372 protein localization to microtubule 2/689 16/18670 0.1161 0.5064 0.4699 MAP1A/TTBK2 2 BP GO:0042222 interleukin-1 biosynthetic process 2/689 16/18670 0.1161 0.5064 0.4699 APP/EGR1 2 BP GO:0042448 progesterone metabolic process 2/689 16/18670 0.1161 0.5064 0.4699 EGR1/AKR1C3 2 BP GO:0043217 myelin maintenance 2/689 16/18670 0.1161 0.5064 0.4699 CLU/MIR26A1 2 BP GO:0045986 negative regulation of smooth muscle contraction 2/689 16/18670 0.1161 0.5064 0.4699 PTGS2/GUCY1A1 2 BP GO:0051447 negative regulation of meiotic cell cycle 2/689 16/18670 0.1161 0.5064 0.4699 DUSP1/MOS 2 BP GO:0055119 relaxation of cardiac muscle 2/689 16/18670 0.1161 0.5064 0.4699 PDE4B/PDE5A 2 BP GO:0061158 3'-UTR-mediated mRNA destabilization 2/689 16/18670 0.1161 0.5064 0.4699 ZFP36/MOV10 2 BP GO:0061684 chaperone-mediated autophagy 2/689 16/18670 0.1161 0.5064 0.4699 PLK3/CLU 2 BP GO:0070293 renal absorption 2/689 16/18670 0.1161 0.5064 0.4699 AKR1C3/SGK1 2 BP GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 2/689 16/18670 0.1161 0.5064 0.4699 RAMP3/ATP2B4 2 BP GO:1902001 fatty acid transmembrane transport 2/689 16/18670 0.1161 0.5064 0.4699 PRKAG2/THBS1 2 BP GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/689 16/18670 0.1161 0.5064 0.4699 TAF9B/ING2 2 BP GO:1902992 negative regulation of amyloid precursor protein catabolic process 2/689 16/18670 0.1161 0.5064 0.4699 CLU/BIN1 2 BP GO:1990000 amyloid fibril formation 2/689 16/18670 0.1161 0.5064 0.4699 APP/CLU 2 BP GO:0031623 receptor internalization 7/689 111/18670 0.1164 0.5066 0.4701 RAMP3/CXCL8/EGF/CEACAM1/RAB31/ANKRD13B/ITGB3 7 BP GO:0072676 lymphocyte migration 7/689 111/18670 0.1164 0.5066 0.4701 ICAM1/APP/CYP7B1/GCSAM/CCL7/AIF1/ZAP70 7 BP GO:0060541 respiratory system development 11/689 198/18670 0.1165 0.5066 0.4701 JMJD6/GNG8/FBXW7/HES1/CCN2/TAB1/NOS3/LOXL3/THRA/SAV1/SMCHD1 11 BP GO:0034612 response to tumor necrosis factor 16/689 312/18670 0.1166 0.5066 0.4701 PTGS2/GBP2/GCH1/GBP1/STAT1/CXCL8/NUB1/ICAM1/TRAF3/TNFAIP3/ZFP36/CCL7/RNF31/THBS1/NR1D1/TNFRSF4 16 BP GO:1990845 adaptive thermogenesis 9/689 154/18670 0.1169 0.5076 0.471 G0S2/BMP8A/LEPR/PM20D1/ADRB3/LEP/NR1D1/IL15/THRA 9 BP GO:0001936 regulation of endothelial cell proliferation 10/689 176/18670 0.1171 0.5076 0.471 EGR3/STAT1/MIR26A1/THBS1/LEP/MIR129-1/CAV2/ITGB3/MIR22/ZNF580 10 BP GO:0051897 positive regulation of protein kinase B signaling 10/689 176/18670 0.1171 0.5076 0.471 RAMP3/EGF/OSM/GCNT2/TSPYL5/AKR1C3/PTK2/THBS1/P2RY12/LEP 10 BP GO:0001666 response to hypoxia 18/689 359/18670 0.1174 0.5083 0.4716 PTGS2/PMAIP1/NR4A2/SLC2A1/ICAM1/PLK3/EGR1/PDLIM1/PLOD2/CHCHD2/OPRD1/PGK1/THBS1/ROCK2/MPL/ITPR2/LEP/PRKCE 18 BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 12/689 221/18670 0.1181 0.5109 0.4741 RAMP3/ADGRE5/ADRA1B/GNAZ/CORT/OPRD1/ATP2B4/P2RY12/GNA13/ADRB3/CHRM5/OR56A1 12 BP GO:0006213 pyrimidine nucleoside metabolic process 4/689 51/18670 0.1184 0.5117 0.4748 NT5C3A/NME4/NME7/UCK2 4 BP GO:0051896 regulation of protein kinase B signaling 13/689 244/18670 0.119 0.5139 0.4768 RAMP3/EGF/OSM/GCNT2/MUL1/TSPYL5/AKR1C3/KLF4/PTK2/THBS1/P2RY12/LEP/BTN2A2 13 BP GO:0014909 smooth muscle cell migration 6/689 91/18670 0.1199 0.5145 0.4774 TPM1/ADAMTS1/MIR26A1/AIF1/ITGB3/TRIB1 6 BP GO:0030510 regulation of BMP signaling pathway 6/689 91/18670 0.1199 0.5145 0.4774 PCSK6/RBPMS2/HES1/MIR26A1/MSX1/TWSG1 6 BP GO:0045639 positive regulation of myeloid cell differentiation 6/689 91/18670 0.1199 0.5145 0.4774 FOS/STAT1/KLF10/SMAP1/MPL/TRIB1 6 BP GO:1904063 negative regulation of cation transmembrane transport 6/689 91/18670 0.1199 0.5145 0.4774 SESTD1/PKD2/MIR26A1/TLR9/BIN1/PRKCE 6 BP GO:0009201 ribonucleoside triphosphate biosynthetic process 10/689 177/18670 0.1203 0.5145 0.4774 APP/DNAJC30/PRKAG2/NUP188/NME4/PGK1/ADPGK/NME7/AK9/UCK2 10 BP GO:1902652 secondary alcohol metabolic process 9/689 155/18670 0.1203 0.5145 0.4774 APP/APOL1/MVK/CYP7B1/LEPR/GPAM/SNX17/SMPD1/LEP 9 BP GO:0003279 cardiac septum development 7/689 112/18670 0.1205 0.5145 0.4774 ACVR1/HES1/SNX17/TAB1/DCTN5/NOS3/SAV1 7 BP GO:0014902 myotube differentiation 7/689 112/18670 0.1205 0.5145 0.4774 PLEKHO1/SELENON/SMYD1/XK/CAV2/MYOF/KLF5 7 BP GO:0044782 cilium organization 19/689 384/18670 0.1206 0.5145 0.4774 ARL6/PKD2/TCTN2/ABLIM3/CDC14B/TMEM107/SCLT1/CCNO/ONECUT2/NOTO/TTLL1/CNTRL/TPGS1/IFT22/IQCB1/EHD3/TTBK2/RAB11A/PLK1 19 BP GO:0002756 MyD88-independent toll-like receptor signaling pathway 3/689 33/18670 0.121 0.5145 0.4774 TRAF3/TBK1/PRKCE 3 BP GO:0006891 intra-Golgi vesicle-mediated transport 3/689 33/18670 0.121 0.5145 0.4774 NAPA/VTI1B/RAB6B 3 BP GO:0010591 regulation of lamellipodium assembly 3/689 33/18670 0.121 0.5145 0.4774 FSCN1/AUTS2/NCKAP1 3 BP GO:0014072 response to isoquinoline alkaloid 3/689 33/18670 0.121 0.5145 0.4774 FOSB/AIF1/PRKCE 3 BP GO:0019692 deoxyribose phosphate metabolic process 3/689 33/18670 0.121 0.5145 0.4774 OGG1/DCTPP1/AK9 3 BP GO:0019934 cGMP-mediated signaling 3/689 33/18670 0.121 0.5145 0.4774 PDE3A/GUCY1B1/THBS1 3 BP GO:0030513 positive regulation of BMP signaling pathway 3/689 33/18670 0.121 0.5145 0.4774 HES1/MSX1/TWSG1 3 BP GO:0043278 response to morphine 3/689 33/18670 0.121 0.5145 0.4774 FOSB/AIF1/PRKCE 3 BP GO:0050795 regulation of behavior 5/689 71/18670 0.1213 0.5155 0.4784 PTGDS/LEPR/PER3/NR1D1/HOXA1 5 BP GO:0006165 nucleoside diphosphate phosphorylation 8/689 134/18670 0.123 0.5212 0.4836 APP/PRKAG2/NUP188/NME4/PGK1/ADPGK/NME7/AK9 8 BP GO:0007272 ensheathment of neurons 8/689 134/18670 0.123 0.5212 0.4836 EGR2/NKX6-2/PARD3/CLU/MIR26A1/GJC3/XK/WASF3 8 BP GO:0008366 axon ensheathment 8/689 134/18670 0.123 0.5212 0.4836 EGR2/NKX6-2/PARD3/CLU/MIR26A1/GJC3/XK/WASF3 8 BP GO:0045137 development of primary sexual characteristics 12/689 223/18670 0.1238 0.5231 0.4854 ICAM1/ADAMTS1/AKR1C3/H3-3B/GDF9/DMC1/REC8/LEP/NRIP1/ING2/NOS3/BCL2L2 12 BP GO:0090287 regulation of cellular response to growth factor stimulus 15/689 292/18670 0.1243 0.5231 0.4854 PCSK6/VEPH1/FGFBP3/RBPMS2/ONECUT2/RASL11B/HES1/MIR26A1/THBS1/CAV2/MSX1/ING2/TWSG1/ITGB3/MYOF 15 BP GO:1904894 positive regulation of STAT cascade 6/689 92/18670 0.1245 0.5231 0.4854 OSM/SOCS3/PARP14/HES1/LEP/IL15 6 BP GO:0015872 dopamine transport 4/689 52/18670 0.1247 0.5231 0.4854 SLC18A2/DTNBP1/CHRM5/OR56A1 4 BP GO:0032653 regulation of interleukin-10 production 4/689 52/18670 0.1247 0.5231 0.4854 PDCD1LG2/TLR9/CLEC7A/CD83 4 BP GO:0048168 regulation of neuronal synaptic plasticity 4/689 52/18670 0.1247 0.5231 0.4854 EGR2/APP/HRAS/RAB11A 4 BP GO:0051438 regulation of ubiquitin-protein transferase activity 4/689 52/18670 0.1247 0.5231 0.4854 CDC14B/FBXW7/MASTL/PLK1 4 BP GO:1902373 negative regulation of mRNA catabolic process 4/689 52/18670 0.1247 0.5231 0.4854 DND1/ZFP36/PABPC1/BOLL 4 BP GO:2000677 regulation of transcription regulatory region DNA binding 4/689 52/18670 0.1247 0.5231 0.4854 KLF4/FBXW7/ZNF593/MSX1 4 BP GO:2000772 regulation of cellular senescence 4/689 52/18670 0.1247 0.5231 0.4854 ARG2/HMGA1/ING2/MIR22 4 BP GO:0090114 COPII-coated vesicle budding 5/689 72/18670 0.1267 0.5231 0.4854 NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 5 BP GO:0097191 extrinsic apoptotic signaling pathway 12/689 224/18670 0.1267 0.5231 0.4854 G0S2/PMAIP1/ICAM1/TNFAIP3/PRDX2/ACVR1/CTTN/FAIM/THBS1/MCL1/NOS3/BCL2L2 12 BP GO:0001889 liver development 8/689 135/18670 0.1268 0.5231 0.4854 PKD2/TNFAIP3/FBXW7/ONECUT2/HES1/CEACAM1/IHH/DDX39B 8 BP GO:0060359 response to ammonium ion 8/689 135/18670 0.1268 0.5231 0.4854 FOSB/ATP2B4/ROCK2/SMPD1/AIF1/PRKCE/CHRM5/OR56A1 8 BP GO:0071347 cellular response to interleukin-1 10/689 179/18670 0.1268 0.5231 0.4854 GBP2/GBP1/CXCL8/ICAM1/EGR1/RIPK2/CCL7/PELI1/NR1D1/TAB1 10 BP GO:2001235 positive regulation of apoptotic signaling pathway 10/689 179/18670 0.1268 0.5231 0.4854 G0S2/PMAIP1/YWHAH/NCK2/CHCHD10/FBXW7/PDCD5/THBS1/MCL1/MSX1 10 BP GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 2/689 17/18670 0.1285 0.5231 0.4854 ACVR1/MSX1 2 BP GO:0009070 serine family amino acid biosynthetic process 2/689 17/18670 0.1285 0.5231 0.4854 PSAT1/SEPHS1 2 BP GO:0021514 ventral spinal cord interneuron differentiation 2/689 17/18670 0.1285 0.5231 0.4854 NKX6-2/EVX1 2 BP GO:0021783 preganglionic parasympathetic fiber development 2/689 17/18670 0.1285 0.5231 0.4854 EGR2/HES1 2 BP GO:0031643 positive regulation of myelination 2/689 17/18670 0.1285 0.5231 0.4854 PARD3/WASF3 2 BP GO:0032740 positive regulation of interleukin-17 production 2/689 17/18670 0.1285 0.5231 0.4854 OSM/IL15 2 BP GO:0035988 chondrocyte proliferation 2/689 17/18670 0.1285 0.5231 0.4854 CCN2/IHH 2 BP GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 2/689 17/18670 0.1285 0.5231 0.4854 LOXL3/BATF 2 BP GO:0043649 dicarboxylic acid catabolic process 2/689 17/18670 0.1285 0.5231 0.4854 GLUL/ACOT4 2 BP GO:0045072 regulation of interferon-gamma biosynthetic process 2/689 17/18670 0.1285 0.5231 0.4854 TLR9/CLEC7A 2 BP GO:0045187 regulation of circadian sleep/wake cycle, sleep 2/689 17/18670 0.1285 0.5231 0.4854 PTGDS/PER3 2 BP GO:0048535 lymph node development 2/689 17/18670 0.1285 0.5231 0.4854 POLB/IL15 2 BP GO:0060850 regulation of transcription involved in cell fate commitment 2/689 17/18670 0.1285 0.5231 0.4854 NKX6-2/EVX1 2 BP GO:0061323 cell proliferation involved in heart morphogenesis 2/689 17/18670 0.1285 0.5231 0.4854 HES1/BMP10 2 BP GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 2/689 17/18670 0.1285 0.5231 0.4854 SESTD1/BIN1 2 BP GO:0072673 lamellipodium morphogenesis 2/689 17/18670 0.1285 0.5231 0.4854 PLEKHO1/VIL1 2 BP GO:0099010 modification of postsynaptic structure 2/689 17/18670 0.1285 0.5231 0.4854 STAU1/WASF3 2 BP GO:1903209 positive regulation of oxidative stress-induced cell death 2/689 17/18670 0.1285 0.5231 0.4854 FBXW7/MCL1 2 BP GO:1905331 negative regulation of morphogenesis of an epithelium 2/689 17/18670 0.1285 0.5231 0.4854 PHLDB2/STAT1 2 BP GO:2000001 regulation of DNA damage checkpoint 2/689 17/18670 0.1285 0.5231 0.4854 RNASEH2B/DDX39B 2 BP GO:2000136 regulation of cell proliferation involved in heart morphogenesis 2/689 17/18670 0.1285 0.5231 0.4854 HES1/BMP10 2 BP GO:0009746 response to hexose 11/689 202/18670 0.1286 0.5231 0.4854 PTGS2/ICAM1/VAMP2/EGR1/GLUL/PHPT1/CDK16/THBS1/CCN2/NR1D1/PRKCE 11 BP GO:0002688 regulation of leukocyte chemotaxis 7/689 114/18670 0.1288 0.5231 0.4854 DUSP1/CXCL8/C5/CCL7/THBS1/AIF1/ZNF580 7 BP GO:0007127 meiosis I 7/689 114/18670 0.1288 0.5231 0.4854 CENPC/CENPS/DMC1/REC8/RAD54B/ING2/PLK1 7 BP GO:0042752 regulation of circadian rhythm 7/689 114/18670 0.1288 0.5231 0.4854 PTGDS/ATOH7/KLF10/FBXW7/ROCK2/PER3/NR1D1 7 BP GO:0006903 vesicle targeting 6/689 93/18670 0.1292 0.5231 0.4854 MAP4K2/NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 6 BP GO:1901184 regulation of ERBB signaling pathway 6/689 93/18670 0.1292 0.5231 0.4854 EGF/APP/NCK2/RHBDF2/FBXW7/CEACAM1 6 BP GO:1901655 cellular response to ketone 6/689 93/18670 0.1292 0.5231 0.4854 XRN1/ICAM1/AKR1C3/KLF4/ROCK2/PRKCE 6 BP GO:0016601 Rac protein signal transduction 3/689 34/18670 0.1292 0.5231 0.4854 AUTS2/NCKAP1/AIF1 3 BP GO:0042533 tumor necrosis factor biosynthetic process 3/689 34/18670 0.1292 0.5231 0.4854 APP/THBS1/CLEC7A 3 BP GO:0042534 regulation of tumor necrosis factor biosynthetic process 3/689 34/18670 0.1292 0.5231 0.4854 APP/THBS1/CLEC7A 3 BP GO:0043276 anoikis 3/689 34/18670 0.1292 0.5231 0.4854 TLE1/PTK2/MCL1 3 BP GO:0043368 positive T cell selection 3/689 34/18670 0.1292 0.5231 0.4854 ZAP70/LOXL3/BATF 3 BP GO:0045738 negative regulation of DNA repair 3/689 34/18670 0.1292 0.5231 0.4854 OGG1/RNF169/SMCHD1 3 BP GO:0048566 embryonic digestive tract development 3/689 34/18670 0.1292 0.5231 0.4854 CXCL8/RBPMS2/IHH 3 BP GO:0071868 cellular response to monoamine stimulus 3/689 34/18670 0.1292 0.5231 0.4854 PDE4B/APP/ATP2B4 3 BP GO:0071870 cellular response to catecholamine stimulus 3/689 34/18670 0.1292 0.5231 0.4854 PDE4B/APP/ATP2B4 3 BP GO:0007160 cell-matrix adhesion 12/689 225/18670 0.1296 0.5244 0.4866 PHLDB2/SLK/TESK2/CTTN/PTK2/ONECUT2/THBS1/CCN2/ROCK2/ITGB5/ITGB3/CCL28 12 BP GO:0006302 double-strand break repair 13/689 248/18670 0.13 0.5248 0.487 UVRAG/NBN/MORF4L1/POLB/OGG1/MDC1/RNF169/DMC1/REC8/RAD54B/H4C8/SETX/SMCHD1 13 BP GO:0042180 cellular ketone metabolic process 13/689 248/18670 0.13 0.5248 0.487 PTGS2/GPD2/PRKAG2/EGR1/AKR1C3/CEACAM1/PPTC7/ATP2B4/ODC1/NR1D1/COQ4/PRKCE/UBIAD1 13 BP GO:0022604 regulation of cell morphogenesis 23/689 484/18670 0.1301 0.5248 0.487 TPM1/GBP1/ICAM1/YWHAH/MUL1/METRN/ARHGAP18/CTTN/PLEKHO1/PTK2/CCL7/XK/GNA13/SIPA1L1/PRPF40A/MPL/PDLIM5/VIL1/WASF3/RTN4R/TRAK1/RAB11A/MOV10 23 BP GO:0046939 nucleotide phosphorylation 8/689 136/18670 0.1306 0.5266 0.4886 APP/PRKAG2/NUP188/NME4/PGK1/ADPGK/NME7/AK9 8 BP GO:0009132 nucleoside diphosphate metabolic process 9/689 158/18670 0.1309 0.5272 0.4892 APP/PRKAG2/NUP188/NME4/TJP2/PGK1/ADPGK/NME7/AK9 9 BP GO:0000186 activation of MAPKK activity 4/689 53/18670 0.1312 0.5272 0.4892 EGF/MOS/RIPK2/TAOK1 4 BP GO:0007131 reciprocal meiotic recombination 4/689 53/18670 0.1312 0.5272 0.4892 CENPS/DMC1/REC8/RAD54B 4 BP GO:0050704 regulation of interleukin-1 secretion 4/689 53/18670 0.1312 0.5272 0.4892 TNFAIP3/RIPK2/ARG2/PANX1 4 BP GO:0016236 macroautophagy 15/689 295/18670 0.1319 0.5286 0.4905 ATP6V0A2/UVRAG/NPRL2/PRKAG2/TOMM5/ATP6V0E2/TOMM6/RIPK2/LAMTOR1/TBK1/PIM2/RUBCN/STX17/CALCOCO2/ATP6V1G2 15 BP GO:0050727 regulation of inflammatory response 23/689 485/18670 0.1321 0.5286 0.4905 PTGS2/MGLL/OSM/NFKBIZ/SOCS3/GBP5/METRNL/TNFAIP3/MVK/SERPING1/CLU/KLF4/C5/MIR26A1/TLR9/CLEC7A/CNR2/LEP/NR1D1/C2CD4A/IL15/MIR22/CPN2 23 BP GO:0046128 purine ribonucleoside metabolic process 5/689 73/18670 0.1321 0.5286 0.4905 NME4/TJP2/PRTFDC1/APRT/NME7 5 BP GO:0072401 signal transduction involved in DNA integrity checkpoint 5/689 73/18670 0.1321 0.5286 0.4905 BTG2/PLK3/PLAGL1/CDC14B/PLK1 5 BP GO:0072422 signal transduction involved in DNA damage checkpoint 5/689 73/18670 0.1321 0.5286 0.4905 BTG2/PLK3/PLAGL1/CDC14B/PLK1 5 BP GO:0046660 female sex differentiation 7/689 115/18670 0.1331 0.5319 0.4935 ICAM1/ADAMTS1/GDF9/DMC1/LEP/NRIP1/NOS3 7 BP GO:0060271 cilium assembly 18/689 366/18670 0.1332 0.5319 0.4935 ARL6/TCTN2/ABLIM3/CDC14B/TMEM107/SCLT1/CCNO/ONECUT2/NOTO/TTLL1/CNTRL/TPGS1/IFT22/IQCB1/EHD3/TTBK2/RAB11A/PLK1 18 BP GO:0010565 regulation of cellular ketone metabolic process 10/689 181/18670 0.1335 0.5327 0.4943 PTGS2/PRKAG2/EGR1/AKR1C3/CEACAM1/PPTC7/ATP2B4/ODC1/NR1D1/PRKCE 10 BP GO:0014706 striated muscle tissue development 19/689 390/18670 0.1338 0.5333 0.4948 TPM1/EGR2/FOS/BTG2/EGR1/MYOM1/PITX1/ACVR1/SELENON/SMYD1/HOXD9/XK/BMP10/CAV2/PDLIM5/MTPN/KLF5/SAV1/DDX39B 19 BP GO:0060048 cardiac muscle contraction 8/689 137/18670 0.1346 0.5333 0.4948 TPM1/PDE4B/ADRA1B/CCN2/BMP10/PDE5A/BIN1/EHD3 8 BP GO:0072655 establishment of protein localization to mitochondrion 8/689 137/18670 0.1346 0.5333 0.4948 PMAIP1/TOMM5/YWHAH/LEPROT/ABLIM3/FBXW7/RNF31/PDCD5 8 BP GO:1903670 regulation of sprouting angiogenesis 8/689 137/18670 0.1346 0.5333 0.4948 PTGS2/GLUL/KLF4/FBXW7/CEACAM1/MIR26A1/THBS1/MIR22 8 BP GO:0071383 cellular response to steroid hormone stimulus 13/689 250/18670 0.1357 0.5333 0.4948 NR4A2/RNF4/ICAM1/YWHAH/ZFP36/CYP7B1/AKR1C3/GPAM/TRIM68/NRIP1/NR1D1/THRA/RBFOX2 13 BP GO:0009064 glutamine family amino acid metabolic process 5/689 74/18670 0.1377 0.5333 0.4948 GLUL/ARG2/GLYATL1/ATP2B4/NOS3 5 BP GO:0031670 cellular response to nutrient 5/689 74/18670 0.1377 0.5333 0.4948 PTGS2/CASTOR1/P2RY12/LEP/IL15 5 BP GO:0032677 regulation of interleukin-8 production 5/689 74/18670 0.1377 0.5333 0.4948 DDX58/KLF4/TLR9/CLEC7A/ZNF580 5 BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 5/689 74/18670 0.1377 0.5333 0.4948 NFKBIZ/RIPK2/CD83/LOXL3/BATF 5 BP GO:0043507 positive regulation of JUN kinase activity 5/689 74/18670 0.1377 0.5333 0.4948 MAP4K2/MUL1/RIPK2/TLR9/TAOK1 5 BP GO:0048199 vesicle targeting, to, from or within Golgi 5/689 74/18670 0.1377 0.5333 0.4948 NAPA/CNIH3/TRAPPC2L/PREB/TRAPPC9 5 BP GO:0050710 negative regulation of cytokine secretion 5/689 74/18670 0.1377 0.5333 0.4948 GBP1/TNFAIP3/ARG2/TNFRSF4/BTN2A2 5 BP GO:0051145 smooth muscle cell differentiation 5/689 74/18670 0.1377 0.5333 0.4948 ACVR1/RBPMS2/HES1/MIR26A1/MIR22 5 BP GO:0072395 signal transduction involved in cell cycle checkpoint 5/689 74/18670 0.1377 0.5333 0.4948 BTG2/PLK3/PLAGL1/CDC14B/PLK1 5 BP GO:0001881 receptor recycling 3/689 35/18670 0.1377 0.5333 0.4948 RAMP3/LAMTOR1/EHD3 3 BP GO:0003203 endocardial cushion morphogenesis 3/689 35/18670 0.1377 0.5333 0.4948 ACVR1/MSX1/NOS3 3 BP GO:0009262 deoxyribonucleotide metabolic process 3/689 35/18670 0.1377 0.5333 0.4948 OGG1/DCTPP1/AK9 3 BP GO:0014904 myotube cell development 3/689 35/18670 0.1377 0.5333 0.4948 SELENON/XK/CAV2 3 BP GO:0019076 viral release from host cell 3/689 35/18670 0.1377 0.5333 0.4948 TRIM26/ZNF502/CAV2 3 BP GO:0035890 exit from host 3/689 35/18670 0.1377 0.5333 0.4948 TRIM26/ZNF502/CAV2 3 BP GO:0035891 exit from host cell 3/689 35/18670 0.1377 0.5333 0.4948 TRIM26/ZNF502/CAV2 3 BP GO:0045622 regulation of T-helper cell differentiation 3/689 35/18670 0.1377 0.5333 0.4948 NFKBIZ/RIPK2/LOXL3 3 BP GO:0046131 pyrimidine ribonucleoside metabolic process 3/689 35/18670 0.1377 0.5333 0.4948 NME4/NME7/UCK2 3 BP GO:0048333 mesodermal cell differentiation 3/689 35/18670 0.1377 0.5333 0.4948 KLF4/KDM6A/ITGB3 3 BP GO:0051294 establishment of spindle orientation 3/689 35/18670 0.1377 0.5333 0.4948 MOS/PLK1/SAPCD2 3 BP GO:0051354 negative regulation of oxidoreductase activity 3/689 35/18670 0.1377 0.5333 0.4948 MIR26A1/ATP2B4/CNR2 3 BP GO:0052126 movement in host environment 3/689 35/18670 0.1377 0.5333 0.4948 TRIM26/ZNF502/CAV2 3 BP GO:0052192 movement in environment of other organism involved in symbiotic interaction 3/689 35/18670 0.1377 0.5333 0.4948 TRIM26/ZNF502/CAV2 3 BP GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3/689 35/18670 0.1377 0.5333 0.4948 TNFAIP3/RIPK2/TAB1 3 BP GO:0071108 protein K48-linked deubiquitination 3/689 35/18670 0.1377 0.5333 0.4948 TNFAIP3/USP25/VCPIP1 3 BP GO:0110111 negative regulation of animal organ morphogenesis 3/689 35/18670 0.1377 0.5333 0.4948 STAT1/FBXW7/CEACAM1 3 BP GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3/689 35/18670 0.1377 0.5333 0.4948 PMAIP1/YWHAH/CHCHD10 3 BP GO:0006336 DNA replication-independent nucleosome assembly 4/689 54/18670 0.1379 0.5333 0.4948 CENPC/H3-3B/CENPS/H4C8 4 BP GO:0035825 homologous recombination 4/689 54/18670 0.1379 0.5333 0.4948 CENPS/DMC1/REC8/RAD54B 4 BP GO:0043392 negative regulation of DNA binding 4/689 54/18670 0.1379 0.5333 0.4948 FBXW7/ID3/ZNF593/MSX1 4 BP GO:0046164 alcohol catabolic process 4/689 54/18670 0.1379 0.5333 0.4948 GPD2/SYNJ2/AKR1C3/SNX17 4 BP GO:0097345 mitochondrial outer membrane permeabilization 4/689 54/18670 0.1379 0.5333 0.4948 PMAIP1/YWHAH/MUL1/CHCHD10 4 BP GO:1904645 response to amyloid-beta 4/689 54/18670 0.1379 0.5333 0.4948 RAMP3/ICAM1/APP/BCL2L2 4 BP GO:0061008 hepaticobiliary system development 8/689 138/18670 0.1385 0.5353 0.4967 PKD2/TNFAIP3/FBXW7/ONECUT2/HES1/CEACAM1/IHH/DDX39B 8 BP GO:0007059 chromosome segregation 16/689 321/18670 0.1386 0.5353 0.4967 DUSP1/UVRAG/KLHDC8B/MOS/RIOK3/CENPC/FBXW7/RCC1/CENPS/DMC1/HASPIN/REC8/RAB11A/PLK1/SKA1/ANAPC1 16 BP GO:0050810 regulation of steroid biosynthetic process 6/689 95/18670 0.1389 0.5357 0.4971 EGR1/MVK/AKR1C3/GPAM/LEP/NR1D1 6 BP GO:0006909 phagocytosis 18/689 369/18670 0.1403 0.5357 0.4971 SIRPB1/RHOBTB1/JMJD6/LEPR/PTK2/RAB31/SPON2/NCKAP1/THBS1/RUBCN/CLEC7A/LEP/RHOBTB2/AIF1/CD247/PRKCE/ITGB3/IL15 18 BP GO:0006349 regulation of gene expression by genetic imprinting 2/689 18/18670 0.1412 0.5357 0.4971 PCGF5/PRMT7 2 BP GO:0007221 positive regulation of transcription of Notch receptor target 2/689 18/18670 0.1412 0.5357 0.4971 STAT1/PBX1 2 BP GO:0009048 dosage compensation by inactivation of X chromosome 2/689 18/18670 0.1412 0.5357 0.4971 PCGF5/SMCHD1 2 BP GO:0009200 deoxyribonucleoside triphosphate metabolic process 2/689 18/18670 0.1412 0.5357 0.4971 DCTPP1/AK9 2 BP GO:0009312 oligosaccharide biosynthetic process 2/689 18/18670 0.1412 0.5357 0.4971 SLC2A1/B3GALT2 2 BP GO:0010612 regulation of cardiac muscle adaptation 2/689 18/18670 0.1412 0.5357 0.4971 ATP2B4/BMP10 2 BP GO:0039535 regulation of RIG-I signaling pathway 2/689 18/18670 0.1412 0.5357 0.4971 GPATCH3/DDX60 2 BP GO:0042095 interferon-gamma biosynthetic process 2/689 18/18670 0.1412 0.5357 0.4971 TLR9/CLEC7A 2 BP GO:0043555 regulation of translation in response to stress 2/689 18/18670 0.1412 0.5357 0.4971 PPP1R15A/NCK2 2 BP GO:0044320 cellular response to leptin stimulus 2/689 18/18670 0.1412 0.5357 0.4971 LEPR/LEP 2 BP GO:0048557 embryonic digestive tract morphogenesis 2/689 18/18670 0.1412 0.5357 0.4971 RBPMS2/IHH 2 BP GO:0051895 negative regulation of focal adhesion assembly 2/689 18/18670 0.1412 0.5357 0.4971 PHLDB2/THBS1 2 BP GO:0060546 negative regulation of necroptotic process 2/689 18/18670 0.1412 0.5357 0.4971 PELI1/MIR22 2 BP GO:0070233 negative regulation of T cell apoptotic process 2/689 18/18670 0.1412 0.5357 0.4971 ARG2/TSC22D3 2 BP GO:0071318 cellular response to ATP 2/689 18/18670 0.1412 0.5357 0.4971 PTGS2/P2RY12 2 BP GO:0090196 regulation of chemokine secretion 2/689 18/18670 0.1412 0.5357 0.4971 C5/AIF1 2 BP GO:0150079 negative regulation of neuroinflammatory response 2/689 18/18670 0.1412 0.5357 0.4971 MIR26A1/NR1D1 2 BP GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/689 18/18670 0.1412 0.5357 0.4971 TAF9B/ING2 2 BP GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 2/689 18/18670 0.1412 0.5357 0.4971 ATP2B4/BMP10 2 BP GO:2000319 regulation of T-helper 17 cell differentiation 2/689 18/18670 0.1412 0.5357 0.4971 NFKBIZ/LOXL3 2 CC GO:0032432 actin filament bundle 12/714 75/19717 1.495e-05 0.003683 0.003552 TPM1/FSCN1/PRICKLE4/ABLIM3/PDLIM1/PTK2/MYLK/MYL9/ROR1/PDLIM5/VIL1/DAAM1 12 CC GO:0031091 platelet alpha granule 13/714 91/19717 2.347e-05 0.003683 0.003552 GTPBP2/EGF/APP/F13A1/PLG/VTI1B/SERPING1/CLU/THBS1/MMRN1/SELP/SYTL4/ITGB3 13 CC GO:0001725 stress fiber 11/714 67/19717 2.631e-05 0.003683 0.003552 TPM1/FSCN1/PRICKLE4/ABLIM3/PDLIM1/PTK2/MYLK/MYL9/ROR1/PDLIM5/DAAM1 11 CC GO:0097517 contractile actin filament bundle 11/714 67/19717 2.631e-05 0.003683 0.003552 TPM1/FSCN1/PRICKLE4/ABLIM3/PDLIM1/PTK2/MYLK/MYL9/ROR1/PDLIM5/DAAM1 11 CC GO:0042641 actomyosin 11/714 79/19717 0.0001248 0.01304 0.01258 TPM1/FSCN1/PRICKLE4/ABLIM3/PDLIM1/PTK2/MYLK/MYL9/ROR1/PDLIM5/DAAM1 11 CC GO:0031093 platelet alpha granule lumen 10/714 67/19717 0.0001397 0.01304 0.01258 GTPBP2/EGF/APP/F13A1/PLG/VTI1B/SERPING1/CLU/THBS1/MMRN1 10 CC GO:0098562 cytoplasmic side of membrane 15/714 178/19717 0.002121 0.1697 0.1636 TRAF3/PTPN7/PKD2/GNG4/GNAZ/GNG8/CDK16/RNF31/GNA13/SPPL3/PTP4A1/CNR2/CAV2/GNG12/NPTX2 15 CC GO:0009898 cytoplasmic side of plasma membrane 13/714 154/19717 0.004019 0.2188 0.211 TRAF3/PTPN7/GNG4/GNAZ/GNG8/CDK16/RNF31/GNA13/PTP4A1/CNR2/CAV2/GNG12/NPTX2 13 CC GO:0005834 heterotrimeric G-protein complex 5/714 30/19717 0.004125 0.2188 0.211 GNG4/GNAZ/GNG8/GNA13/GNG12 5 CC GO:1905360 GTPase complex 5/714 30/19717 0.004125 0.2188 0.211 GNG4/GNAZ/GNG8/GNA13/GNG12 5 CC GO:0000805 X chromosome 3/714 10/19717 0.004689 0.2188 0.211 PCGF5/H3-3B/SMCHD1 3 CC GO:0033655 host cell cytoplasm part 3/714 10/19717 0.004689 0.2188 0.211 GBP2/GBP7/GBP4 3 CC GO:0031941 filamentous actin 5/714 32/19717 0.005492 0.2343 0.2259 PKD2/PRICKLE4/PDLIM1/NCKAP1/PDLIM5 5 CC GO:0030430 host cell cytoplasm 3/714 11/19717 0.006275 0.2343 0.2259 GBP2/GBP7/GBP4 3 CC GO:0031680 G-protein beta/gamma-subunit complex 3/714 11/19717 0.006275 0.2343 0.2259 GNG4/GNG8/GNG12 3 CC GO:0005884 actin filament 10/714 111/19717 0.007032 0.2461 0.2373 TPM1/PSTPIP2/PKD2/PRICKLE4/CTTN/PDLIM1/NCKAP1/PDLIM5/AIF1/GNG12 10 CC GO:0005845 mRNA cap binding complex 3/714 12/19717 0.008144 0.2525 0.2434 EIF4E2/ZFP36/AGO2 3 CC GO:0005901 caveola 8/714 80/19717 0.008322 0.2525 0.2434 PTGS2/SLC2A1/ADRA1B/ATP2B4/P2RY12/CAV2/MYOF/NOS3 8 CC GO:0030018 Z disc 11/714 132/19717 0.008565 0.2525 0.2434 SLC2A1/PDE4B/NEXN/MYOM1/PRICKLE4/PDLIM1/ATP2B4/BMP10/MYL9/PDLIM5/BIN1 11 CC GO:0030027 lamellipodium 14/714 193/19717 0.01077 0.2979 0.2873 APP/PKD2/FSCN1/CTTN/ABLIM3/SLC39A14/PTK2/NCKAP1/MYLK/VIL1/WASF3/AIF1/ITGB3/PLEKHG5 14 CC GO:0005791 rough endoplasmic reticulum 8/714 85/19717 0.01182 0.2979 0.2873 PTGDS/APP/GLUL/RPL4/PLOD2/STAU1/SPPL3/RPS23 8 CC GO:0033646 host intracellular part 3/714 14/19717 0.01277 0.2979 0.2873 GBP2/GBP7/GBP4 3 CC GO:0034518 RNA cap binding complex 3/714 14/19717 0.01277 0.2979 0.2873 EIF4E2/ZFP36/AGO2 3 CC GO:0043656 intracellular region of host 3/714 14/19717 0.01277 0.2979 0.2873 GBP2/GBP7/GBP4 3 CC GO:0031674 I band 11/714 143/19717 0.01502 0.3253 0.3137 SLC2A1/PDE4B/NEXN/MYOM1/PRICKLE4/PDLIM1/ATP2B4/BMP10/MYL9/PDLIM5/BIN1 11 CC GO:0000778 condensed nuclear chromosome kinetochore 3/714 15/19717 0.01554 0.3253 0.3137 CENPC/REC8/PLK1 3 CC GO:0090575 RNA polymerase II transcription factor complex 12/714 163/19717 0.01568 0.3253 0.3137 FOS/GTF2F2/JUNB/JUND/MAX/TLE1/TAF9B/HMGA1/NR1D1/ING2/THRA/PBX1 12 CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 8/714 91/19717 0.01731 0.3463 0.3339 GNG4/GNAZ/GNG8/CDK16/GNA13/CNR2/CAV2/GNG12 8 CC GO:0033643 host cell part 3/714 16/19717 0.01862 0.3595 0.3467 GBP2/GBP7/GBP4 3 CC GO:0030176 integral component of endoplasmic reticulum membrane 11/714 150/19717 0.0207 0.3852 0.3714 TAP2/AMFR/ELOVL4/PKD2/DOLK/SLC37A1/PREB/SPPL3/TAP1/DOLPP1/ALG3 11 CC GO:0030426 growth cone 12/714 171/19717 0.02198 0.3852 0.3714 TMOD2/AMFR/APP/FSCN1/PARD3/CTTN/AUTS2/DTNBP1/RTN4R/TRAK1/SETX/NPTX2 12 CC GO:0031092 platelet alpha granule membrane 3/714 17/19717 0.02201 0.3852 0.3714 SELP/SYTL4/ITGB3 3 CC GO:0030427 site of polarized growth 12/714 176/19717 0.02677 0.4543 0.4381 TMOD2/AMFR/APP/FSCN1/PARD3/CTTN/AUTS2/DTNBP1/RTN4R/TRAK1/SETX/NPTX2 12 CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 11/714 158/19717 0.02897 0.4772 0.4602 TAP2/AMFR/ELOVL4/PKD2/DOLK/SLC37A1/PREB/SPPL3/TAP1/DOLPP1/ALG3 11 CC GO:0150034 distal axon 17/714 285/19717 0.03098 0.4921 0.4745 TMOD2/AMFR/APP/SLC18A2/FSCN1/PARD3/GLUL/CTTN/AUTS2/OPRD1/CABP4/DTNBP1/ROR1/RTN4R/TRAK1/SETX/NPTX2 17 CC GO:0044798 nuclear transcription factor complex 13/714 201/19717 0.03163 0.4921 0.4745 FOS/GTF2F2/JUNB/JUND/MAX/KLF4/TLE1/TAF9B/HMGA1/NR1D1/ING2/THRA/PBX1 13 CC GO:0030016 myofibril 14/714 224/19717 0.03394 0.5137 0.4953 TPM1/TMOD2/SLC2A1/PDE4B/NEXN/MYOM1/PRICKLE4/PDLIM1/CALD1/ATP2B4/BMP10/MYL9/PDLIM5/BIN1 14 CC GO:0030017 sarcomere 13/714 204/19717 0.03504 0.5163 0.4979 TPM1/TMOD2/SLC2A1/PDE4B/NEXN/MYOM1/PRICKLE4/PDLIM1/ATP2B4/BMP10/MYL9/PDLIM5/BIN1 13 MF GO:0003779 actin binding 32/674 431/17697 0.0002608 0.1265 0.1251 TPM1/TMOD2/PSTPIP2/GBP1/FSCN1/NEXN/MYOM1/YWHAH/RUSC1/PRICKLE4/CTTN/MAP1A/ABLIM3/PDLIM1/PANX1/CALD1/PTK2/GCSAM/CEACAM1/CTNNAL1/MYLK/ACTR3B/PDLIM5/VIL1/WASF3/DAAM1/AIF1/ENC1/BIN1/KLHL5/PRKCE/NOS3 32 MF GO:0003924 GTPase activity 25/674 324/17697 0.0006867 0.1265 0.1251 GTPBP2/GBP2/GCH1/GBP1/GBP7/ARL6/GBP5/RHOBTB1/GBP4/GNG4/GPN2/GNAZ/GNG8/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/TUBA8/RHOBTB2/GNG12/RAB11A 25 MF GO:0005525 GTP binding 27/674 374/17697 0.001167 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 27 MF GO:0019001 guanyl nucleotide binding 28/674 394/17697 0.001209 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/PDE5A/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 28 MF GO:0032561 guanyl ribonucleotide binding 28/674 394/17697 0.001209 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/PDE5A/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 28 MF GO:0032550 purine ribonucleoside binding 27/674 378/17697 0.001363 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 27 MF GO:0051371 muscle alpha-actinin binding 5/674 23/17697 0.001501 0.1265 0.1251 PKD2/MYOM1/PRICKLE4/PDLIM1/PDLIM5 5 MF GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 30/674 439/17697 0.001519 0.1265 0.1251 EGR2/CSRNP1/NR4A2/FOS/STAT1/JUNB/IRF1/PLAGL1/STAT2/GSX1/EGR1/JUND/PITX1/KLF10/GLIS1/KLF4/ONECUT2/HOXB3/FOSB/KLF6/MSX1/OTX1/TLX1/ETV6/HOXA1/BARHL1/KLF5/PBX1/ELF4/BATF 30 MF GO:0001883 purine nucleoside binding 27/674 381/17697 0.001528 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 27 MF GO:0032549 ribonucleoside binding 27/674 382/17697 0.001587 0.1265 0.1251 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 27 MF GO:0001882 nucleoside binding 27/674 389/17697 0.002055 0.1489 0.1473 GTPBP2/GBP2/RANBP17/GCH1/GBP1/GBP7/ARL6/GBP5/GUCY1B1/RHOBTB1/GBP4/GPN2/GNAZ/RASL11B/RAB31/RRAS2/GNA13/RASL12/HRAS/RAB6B/IFT22/GUCY1A1/TUBA8/RHOBTB2/EHD3/RAB11A/SEPHS1 27 MF GO:0001968 fibronectin binding 5/674 27/17697 0.003175 0.2109 0.2086 CTSK/THBS1/CCN2/ITGB3/LOXL3 5 MF GO:0048156 tau protein binding 6/674 45/17697 0.006862 0.4108 0.4064 MAP1A/CLU/ROCK2/TAOK1/BIN1/TTBK2 6 MF GO:0030546 receptor activator activity 3/674 11/17697 0.007217 0.4108 0.4064 EGF/APP/PRKCE 3