ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05168	Herpes simplex virus 1 infection	273/2990	495/8135	6.845e-18	2.286e-15	2.147e-15	ZNF426/RNASEL/ZNF436/ZNF543/ZNF619/AKT2/ZNF597/ZNF550/ZNF764/ZNF235/IKBKB/ZNF155/TNF/SRSF5/ZNF565/ZNF333/ZNF749/EIF2B1/ZNF20/ZNF189/ZNF570/ZNF350/ZNF317/ZNF676/TNFRSF14/ZNF549/ZNF182/ZNF841/ZNF286A/ZNF490/NXF1/ZNF224/ZSCAN32/ZNF555/ZNF3/ZNF17/ZNF623/ZNF221/OAS2/ZNF766/ZNF2/IRF7/BAD/ZNF620/ZNF528/EIF2B4/ZNF416/ZNF398/ZNF823/IKBKE/FASLG/SRSF7/EIF4EBP1/ZNF140/ZNF420/ZNF564/ZNF791/STAT2/ZNF780A/ZFP30/TAB1/ZIK1/ZNF77/ZNF432/BAK1/ZNF571/ZNF473/ZNF222/OAS3/PILRB/ZNF44/ZNF559/ZNF57/ZNF792/MAVS/CHUK/ZNF589/ZNF611/ZNF563/ZNF417/ZNF614/OAS1/ZNF45/ZNF583/C3/PILRA/ZNF658/POU2F2/ZFP14/ZNF721/ZNF551/TSC1/ZNF793/ZNF585B/ZNF79/ZNF778/ZNF763/IFNA21/ZNF689/ZNF283/ZNF285/ZNF669/RBAK/ZNF600/ZNF780B/ZNF641/ZNF701/ZNF284/ZNF441/ZNF354B/ZNF200/ZNF30/ZNF616/ZNF136/ZNF529/ZNF205/ZNF132/ZNF607/PML/ZNF621/ZNF8/ZNF26/ZNF85/ZNF557/ZNF773/ZNF674/ZNF613/ZNF454/ZNF418/ZNF665/ZNF226/ZNF573/ZNF223/ZNF772/ZNF700/EIF2AK1/ZNF568/ZNF624/TICAM1/ZNF714/ZNF718/IRF3/EIF2B3/ZNF175/ZNF527/ZNF93/ZNF566/ZNF713/ZNF443/ZNF699/TP53/TRAF6/ZNF316/ZNF688/ZNF225/ZNF558/ZNF7/ZFP82/ZNF257/ZNF679/SRSF6/ZNF799/ITGA5/ZNF300/ZNF10/PPP1CB/IFIH1/CASP3/SRSF4/AKT1/ZNF615/ZNF184/ZNF786/ZNF304/ZNF540/ZNF567/LTA/ZNF707/ZNF34/ZNF492/ZNF546/ZNF627/IFNA2/ZNF547/ZNF14/ZNF135/EIF2AK4/SRSF9/IFNA5/DDX58/TRADD/ZFP69/ZNF662/ZNF584/ZNF425/CALR/RELA/ZNF677/EIF2S1/ZNF585A/BIRC2/TAP1/ZNF141/ZNF324/SRSF1/ZNF324B/ZNF439/ZNF596/B2M/ZNF442/ZNF160/EIF2B5/SRSF2/ZNF785/TNFRSF1A/HLA-DRA/ZNF90/BCL2/ZNF229/ZNF431/ZNF256/PIK3R3/ZNF606/HLA-DMB/HCFC2/ZNF112/TRAF5/IRF9/ZNF717/ZNF343/ZNF267/ZNF404/ZNF347/ZNF212/ZNF234/CASP8/ZNF836/ZNF671/TAP2/TRAF3/IFNA17/ZNF582/ZNF311/ZNF470/ZNF682/ZNF716/HLA-C/ZNF554/ZNF180/ZNF777/EIF2B2/ZNF468/FADD/ZNF808/ZNF230/ZNF879/ZNF208/ZNF43/ZNF302/ZNF630/ZNF429/ZNF846/ZNF354C/ZNF805/MTOR/APAF1/SRSF3/ZNF101/ZNF133/ZNF337/ZNF84/ZFP37/TSC2	273
KEGG	hsa05132	Salmonella infection	116/2990	249/8135	0.0007861	0.1088	0.1022	RAB7A/RIPK3/SNX18/AKT2/IKBKB/TNF/ACTR10/TUBA3C/DCTN1/MYL12B/ABI1/TIRAP/CTNNB1/EXOC5/DYNC2LI1/VPS39/DCTN6/TAB1/BAK1/CYTH2/KLC4/ARL8B/CHUK/PFN3/FHOD1/DYNLL1/FOS/RAB9B/AHNAK/CYTH1/TNFRSF10B/BRK1/TNFRSF10A/KPNA1/PLEKHM2/ARPC1B/MYL7/PIK3C2A/CYTH4/DYNC1H1/S100A10/DCTN5/TAB3/ELMO2/KIF5B/KLC3/TRAF6/HSP90AA1/DYNLT1/JUN/PLEKHM1/TUBA3E/CASP3/KPNA4/TCF7L2/DYNC1I1/AKT1/ARF1/TXN2/MYL2/RAB5C/KLC1/HSP90AB1/TNFSF10/SKP1/TRADD/RELA/RALA/CASP5/BIRC2/RILP/ACBD3/TUBB3/PIK3C2B/ARPC5L/KIF5A/TNFRSF1A/ACTB/MAPK12/BCL2/TCF7/DYNLRB1/TXN/ARF6/WASL/PFN4/MAP2K3/RRAS/HSP90B1/RHOB/EXOC7/DNM2/TUBB2A/DCTN2/ARPC1A/CASP8/NOD1/MAPK1/CASP7/ROCK2/WASF3/MAPK10/ACTR3B/CYTH3/FYCO1/FADD/MAPK11/MLKL/LY96/DCTN4/GSDMD/MAPK3/ARPC5/TUBB/RAB5A/PKN1	116
KEGG	hsa05213	Endometrial cancer	33/2990	58/8135	0.001367	0.1088	0.1022	AKT2/CTNNB1/BAD/BAK1/PDPK1/GSK3B/GRB2/POLK/GADD45A/KRAS/SOS2/APC2/TP53/ARAF/ERBB2/TCF7L2/AKT1/BRAF/CCND1/FOXO3/CDKN1A/CDH1/NRAS/TCF7/PIK3R3/SOS1/CTNNA2/MAPK1/CTNNA1/PTEN/CTNNA3/MAPK3/GADD45G	33
KEGG	hsa04141	Protein processing in endoplasmic reticulum	82/2990	171/8135	0.001597	0.1088	0.1022	UBE2G1/SAR1B/RNF185/FBXO2/BAK1/PDIA6/UBQLN1/ERP29/ATF6B/UBXN4/SAR1A/DNAJB11/RBX1/STUB1/HSPA1L/UBE2J1/STT3A/FBXO6/GANAB/PREB/EIF2AK1/AMFR/DNAJC1/LMAN2/TXNDC5/BCAP31/DERL1/HSP90AA1/TUSC3/HERPUD1/MOGS/OS9/SEC31A/LMAN1/MBTPS1/SVIP/UBXN2A/YOD1/SEC23A/TRAM1L1/MAP3K5/DNAJB12/MAN1C1/HSP90AB1/SSR1/SKP1/MBTPS2/EIF2AK4/TRAM1/UBE2D4/HSPA5/PPP1R15A/CALR/EIF2S1/PLAA/UBXN6/SEC23B/ATXN3/MAN1A1/SEC61A1/BCL2/SEC24B/HYOU1/HSP90B1/UBQLN4/DERL3/UBQLN2/RAD23B/CASP12/UBE2D3/SEC62/MAPK10/RAD23A/ATF6/SEC61G/DNAJC10/SEC24A/CRYAB/HSPA6/BAG1/SEC24C/ATF4	82
KEGG	hsa04137	Mitophagy - animal	39/2990	72/8135	0.001857	0.1088	0.1022	RAB7A/BECN1/NBR1/MRAS/TAX1BP1/SP1/RRAS2/USP15/AMBRA1/KRAS/TP53/GABARAPL2/FUNDC1/UBA52/JUN/HIF1A/FOXO3/TBC1D17/MAP1LC3B2/RELA/GABARAP/GABARAPL1/USP8/NRAS/RHOT2/RRAS/UBB/MAP1LC3C/RHOT1/CSNK2B/USP30/PINK1/MFN1/MAPK10/UBC/ATG9B/TOMM7/CITED2/ATF4	39
KEGG	hsa03015	mRNA surveillance pathway	50/2990	97/8135	0.001955	0.1088	0.1022	PAPOLA/PABPC3/NUDT21/EIF4A3/CPSF7/PPP2R2D/NXF1/FUS/WDR82/SMG7/DDX39B/UPF1/PABPN1/CLP1/RNGTT/WDR33/GSPT1/PELO/RBM8A/PABPC1/SMG6/HBS1L/DAZAP1/UPF2/GLE1/PCF11/PPP2R5D/PPP2R2A/PPP1CB/PABPC1L2A/PPP2R3B/ACIN1/PPP2R5A/PPP2R5E/SMG5/MAGOHB/GSPT2/CSTF2/SYMPK/PNN/NCBP2/CPSF3/SRRM1/CSTF3/NXT1/MAGOH/PPP2R2C/ETF1/RNPS1/PABPC1L	50
KEGG	hsa05223	Non-small cell lung cancer	38/2990	72/8135	0.003861	0.1842	0.173	AKT2/RB1/BAD/FHIT/BAK1/STAT5A/PLCG1/PDPK1/GRB2/POLK/GADD45A/KRAS/SOS2/TP53/KIF5B/ARAF/RASSF5/ERBB2/JAK3/AKT1/HGF/BRAF/CCND1/FOXO3/CDKN1A/E2F2/PRKCB/CDKN2A/PLCG2/KIF5A/NRAS/RXRB/PIK3R3/RASSF1/SOS1/MAPK1/MAPK3/GADD45G	38
KEGG	hsa04668	TNF signaling pathway	55/2990	112/8135	0.00474	0.1892	0.1776	RIPK3/AKT2/IKBKB/TNF/CSF1/CASP10/MAP3K14/TAB1/CHUK/FOS/NOD2/ATF6B/TRAF1/TAB3/JUN/MAP3K8/CASP3/AKT1/VEGFC/LTA/MAP3K5/CXCL10/JUNB/TNFRSF1B/TRADD/RELA/BIRC2/CREB3L1/DNM1L/TNFRSF1A/MAPK12/MAP2K3/PIK3R3/CREB1/TRAF5/IL18R1/CASP8/TRAF3/MAPK1/CASP7/MAPK10/LIF/MMP14/RPS6KA4/FADD/MAPK11/MLKL/IL15/TNFAIP3/BAG4/ITCH/MAPK3/ATF2/CREB3L4/ATF4	55
KEGG	hsa04210	Apoptosis	65/2990	136/8135	0.005097	0.1892	0.1776	AKT2/DFFA/IKBKB/TNF/TUBA3C/DIABLO/BAD/FASLG/CASP10/MAP3K14/AIFM1/BAK1/CHUK/BBC3/CTSC/FOS/PIDD1/TNFRSF10B/PDPK1/TNFRSF10A/CTSW/GADD45A/KRAS/TRAF1/TP53/JUN/TUBA3E/CASP3/DFFB/AKT1/CASP6/MAP3K5/TNFSF10/PRF1/TRADD/SPTA1/PARP4/RELA/EIF2S1/BIRC2/HRK/HTRA2/NGF/CSF2RB/SPTAN1/TNFRSF1A/ACTB/NRAS/BCL2/PIK3R3/CTSL/MCL1/CASP12/CASP8/MAPK1/CASP7/MAPK10/FADD/GZMB/IL3RA/APAF1/MAPK3/ITPR1/GADD45G/ATF4	65
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	27/2990	49/8135	0.006593	0.2202	0.2068	UGP2/GMDS/GNPDA1/GFPT1/MPI/GNE/UAP1/GALT/PGM3/NAGK/GNPDA2/PMM1/GMPPA/GALE/TSTA3/CYB5R4/CHIT1/GNPNAT1/PMM2/PGM1/PGM2/CYB5RL/GPI/AMDHD2/HK1/CMAS/UAP1L1	27
KEGG	hsa05160	Hepatitis C	73/2990	157/8135	0.007257	0.2204	0.207	RNASEL/EIF3E/AKT2/IKBKB/TNF/YWHAZ/PPP2R2D/RB1/CTNNB1/OAS2/IRF7/BAD/IFIT1/IKBKE/FASLG/MX1/STAT2/BAK1/OAS3/MAVS/CHUK/OAS1/RSAD2/IFNA21/CD81/GSK3B/EIF2AK1/GRB2/TICAM1/CLDN15/IRF3/KRAS/SOS2/TP53/MX2/TRAF6/ARAF/YWHAE/PPP2R2A/CASP3/AKT1/BRAF/CXCL10/IFNA2/CCND1/CDKN1A/EIF2AK4/IFNA5/DDX58/TRADD/E2F2/RELA/EIF2S1/CLDN10/YWHAB/PSME3/CLDN14/TNFRSF1A/NRAS/PIK3R3/SOS1/IRF9/CASP8/TRAF3/IFNA17/MAPK1/FADD/PPP2R2C/APAF1/MAPK3/SCARB1/YWHAQ/CLDN16	73
KEGG	hsa01524	Platinum drug resistance	37/2990	73/8135	0.01008	0.2431	0.2283	AKT2/MDM2/BAD/FASLG/BAK1/BBC3/ABCC2/PDPK1/MGST3/GSTA4/TP53/ERBB2/CASP3/AKT1/TOP2A/ATP7A/MAP3K5/CDKN1A/MGST1/MSH2/GSTA2/BIRC2/CDKN2A/ERCC1/BCL2/XPA/POLH/PIK3R3/CASP8/MAPK1/GSTA5/FADD/MSH6/APAF1/MAPK3/MSH3/GSTM1	37
KEGG	hsa04115	p53 signaling pathway	37/2990	73/8135	0.01008	0.2431	0.2283	MDM2/CCNG2/CCND2/GORAB/BBC3/IGF1/PIDD1/TNFRSF10B/TNFRSF10A/GADD45A/SIAH1/CHEK1/THBS1/TP53/SHISA5/CASP3/GTSE1/CCNE2/CCND1/CDKN1A/SERPINB5/SESN2/CCNE1/CDKN2A/BCL2/MDM4/RRM2/CASP8/CDK1/IGFBP3/PTEN/CCNB2/APAF1/RPRM/ATR/TSC2/GADD45G	37
KEGG	hsa01250	Biosynthesis of nucleotide sugars	21/2990	37/8135	0.01027	0.2431	0.2283	UGP2/GMDS/GFPT1/MPI/GNE/UAP1/GALT/PGM3/NAGK/PMM1/GMPPA/GALE/TSTA3/GNPNAT1/PMM2/PGM1/PGM2/GPI/HK1/CMAS/UAP1L1	21
KEGG	hsa05161	Hepatitis B	74/2990	162/8135	0.0115	0.2431	0.2283	AKT2/IKBKB/TNF/YWHAZ/SMAD4/RB1/TIRAP/IRF7/BAD/IKBKE/FASLG/STAT2/CASP10/TAB1/MAVS/CHUK/STAT5A/FOS/ATF6B/DDX3X/IFNA21/NFATC1/GRB2/TICAM1/IRF3/KRAS/SOS2/TP53/MAP3K1/TRAF6/ARAF/SLC10A1/JUN/JAK3/IFIH1/CASP3/AKT1/BRAF/CCNE2/IFNA2/STAT6/CDKN1A/IFNA5/DDX58/E2F2/RELA/CREB3L1/YWHAB/PRKCB/CCNE1/ATP6AP1/NRAS/MAPK12/BCL2/MAP2K3/PIK3R3/CREB1/SOS1/EGR2/CASP12/CASP8/TRAF3/IFNA17/MAPK1/MAPK10/FADD/MAPK11/CCNA1/APAF1/MAPK3/ATF2/CREB3L4/YWHAQ/ATF4	74
KEGG	hsa05215	Prostate cancer	47/2990	97/8135	0.01164	0.2431	0.2283	AKT2/IKBKB/RB1/CTNNB1/MDM2/BAD/CHUK/IGF1/FGFR2/PDPK1/GSK3B/GRB2/KRAS/SOS2/TP53/ARAF/HSP90AA1/ERBB2/INS/TCF7L2/AKT1/BRAF/CCNE2/HSP90AB1/CCND1/CDKN1A/PDGFC/E2F2/RELA/CREB3L1/CCNE1/NRAS/BCL2/TCF7/PLAU/PIK3R3/HSP90B1/CREB1/SOS1/MAPK1/PDGFB/PTEN/MTOR/MAPK3/NKX3-1/CREB3L4/ATF4	47
KEGG	hsa05221	Acute myeloid leukemia	34/2990	67/8135	0.01302	0.2558	0.2403	AKT2/IKBKB/BAD/EIF4EBP1/CHUK/STAT5A/PML/DUSP6/RARA/GRB2/PIM2/KRAS/SOS2/ARAF/CSF1R/RPS6KB1/TCF7L2/AKT1/BRAF/PPARD/CCND1/RELA/FLT3/NRAS/TCF7/JUP/PIK3R3/SOS1/PER2/MAPK1/CCNA1/MTOR/MAPK3/CEBPA	34
KEGG	hsa03250	Viral life cycle - HIV-1	32/2990	63/8135	0.01546	0.2662	0.25	CHMP4A/NELFA/CPSF7/HGS/CDK9/SMARCB1/MX1/ELL2/SUPT5H/BICD1/FEZ1/NELFCD/MAP1B/NELFB/MX2/SERINC5/CCNT2/PIN1/MAP1S/NUP153/SUPT4H1/PPIA/BICD2/APOBEC3F/SERINC3/FURIN/NELFE/APOBEC3D/APOBEC3B/KAT2B/APOBEC3H/VPS4A	32
KEGG	hsa04622	RIG-I-like receptor signaling pathway	35/2990	70/8135	0.01561	0.2662	0.25	IKBKB/TNF/DHX58/IRF7/IKBKE/CASP10/MAVS/CHUK/DDX3X/IFNA21/NFKBIB/TANK/IRF3/MAP3K1/TRAF6/PIN1/IFIH1/RNF125/CXCL10/IFNA2/IFNA5/DDX58/TRADD/RELA/SIKE1/MAPK12/CASP8/TRAF3/IFNA17/AZI2/MAPK10/FADD/MAPK11/OTUD5/TRIM25	35
KEGG	hsa03013	Nucleocytoplasmic transport	51/2990	108/8135	0.01594	0.2662	0.25	RANGAP1/EIF4A3/SUMO1/UBE2I/NXF1/SUMO2/EEF1A2/EEF1A1/NUP160/DDX39B/UPF1/IPO4/XPO7/KPNA1/NUP85/SUMO4/NUP93/RAE1/PHAX/SNUPN/RBM8A/IPO13/NUP107/NUP188/UPF2/GLE1/THOC3/THOC7/KPNA4/ACIN1/XPOT/NUP153/IPO8/NUP50/MAGOHB/KPNA7/NUP133/PNN/THOC2/THOC6/NCBP2/SUMO3/THOC5/IPO9/SRRM1/NXT1/MAGOH/POM121C/TMEM33/NUP98/RNPS1	51
KEGG	hsa04070	Phosphatidylinositol signaling system	46/2990	97/8135	0.01957	0.3113	0.2924	IP6K2/MTMR7/PIP4K2B/INPP5E/IPPK/IMPA1/DGKZ/MTMR4/PLCG1/PLCB2/PLCD4/MTMR1/DGKK/IP6K1/CALML5/PIK3C2A/PPIP5K2/PIP5K1B/PIP4K2C/INPP4A/DGKA/PIP5K1A/INPP5B/ITPKB/ITPKA/DGKH/PRKCB/INPP5F/PLCG2/PIK3C2B/PIK3R3/MTMR2/PLCE1/CDS1/CALM1/SYNJ2/MTMR8/PI4K2B/IMPAD1/PTEN/PLCD3/PIP4K2A/PLCD1/MTMR6/PI4KB/ITPR1	46
KEGG	hsa00020	Citrate cycle (TCA cycle)	17/2990	30/8135	0.02056	0.3121	0.2931	DLST/ACLY/SUCLG1/CS/IDH3B/DLAT/PDHA2/OGDH/ACO1/PDHB/FH/PCK2/IDH1/PDHA1/DLD/SDHC/PC	17
KEGG	hsa05216	Thyroid cancer	20/2990	37/8135	0.0235	0.3311	0.311	CTNNB1/BAK1/POLK/CCDC6/GADD45A/KRAS/TPM3/TP53/TCF7L2/BRAF/CCND1/CDKN1A/CDH1/NCOA4/NRAS/RXRB/TCF7/MAPK1/MAPK3/GADD45G	20
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/2990	26/8135	0.02379	0.3311	0.311	PIGV/PIGG/PIGM/GPAA1/PGAP1/PIGO/PIGX/PIGC/PIGA/PIGT/PIGH/MPPE1/GPLD1/PIGW/PIGS	15
KEGG	hsa05214	Glioma	36/2990	75/8135	0.02952	0.3711	0.3485	AKT2/RB1/MDM2/BAK1/IGF1/PLCG1/SHC1/CALML5/GRB2/POLK/GADD45A/KRAS/SOS2/TP53/ARAF/AKT1/BRAF/CCND1/CDKN1A/E2F2/PRKCB/CDKN2A/PLCG2/NRAS/CAMK2A/PIK3R3/SOS1/CALM1/MAPK1/CAMK2D/PDGFB/CAMK1/PTEN/MTOR/MAPK3/GADD45G	36
KEGG	hsa04144	Endocytosis	107/2990	251/8135	0.02991	0.3711	0.3485	RAB7A/STAMBP/CHMP4A/ZFYVE27/HGS/CHMP2A/IL2RB/MDM2/CHMP3/WIPF1/CAV1/RAB11B/CYTH2/SNX3/SH3GL2/TFRC/FGFR2/AP2B1/MVB12A/CYTH1/PSD4/NEDD4L/PLD2/PML/VPS37D/HSPA1L/GIT1/WIPF2/ACAP2/ARPC1B/CYTH4/RAB11FIP2/VPS35/IQSEC2/ASAP1/KIF5B/VPS26A/TRAF6/AMPH/FGFR4/NEDD4/DNM1/SPG21/AP2A2/RAB35/CHMP7/RNF41/ARRB1/ARF1/PIP5K1B/AGAP3/RAB5C/AGAP5/SNX6/PIP5K1A/SNF8/CLTB/VPS37A/VPS37C/VPS45/CAPZB/ARAP1/EPS15L1/SNX32/IQSEC1/SMURF2/GBF1/CHMP2B/USP8/ARPC5L/KIF5A/SNX4/CLTA/RABEP1/VPS28/ARF6/WASL/SNX1/CHMP1A/RAB4A/DNAJC6/RAB11FIP5/FOLR2/ARFGAP3/DNM2/ARRB2/FOLR3/VPS36/ARPC1A/LDLRAP1/ACTR3B/HLA-C/AP2M1/CYTH3/GRK5/IST1/VPS4A/ARF4/GIT2/STAM/ITCH/ARPC5/ARAP3/HSPA6/RAB5A/RAB11A/PSD	107
KEGG	hsa04722	Neurotrophin signaling pathway	54/2990	119/8135	0.03193	0.3711	0.3485	AKT2/RAP1A/IKBKB/PRDM4/SH2B1/BAD/FASLG/ZNF274/PLCG1/SHC1/PDPK1/NFKBIB/CALML5/RAP1B/GSK3B/GRB2/MAPKAPK2/KRAS/SOS2/TP53/MAP3K1/TRAF6/YWHAE/JUN/AKT1/BRAF/SH2B3/MAP3K5/MAP2K5/FOXO3/RELA/NGF/GAB1/PLCG2/NRAS/MAPK12/BCL2/CAMK2A/IRAK3/PIK3R3/ARHGDIG/SOS1/FRS2/CALM1/MAPK1/CAMK2D/MAPK10/IRS1/RPS6KA3/MAPK11/NTRK2/NGFR/MAPK3/ATF4	54
KEGG	hsa00562	Inositol phosphate metabolism	35/2990	73/8135	0.03217	0.3711	0.3485	MTMR7/PIP4K2B/INPP5E/IPPK/IMPA1/MTMR4/PLCG1/PLCB2/PLCD4/MTMR1/FIG4/ISYNA1/PIK3C2A/PIP5K1B/PIP4K2C/INPP4A/PIP5K1A/INPP5B/ITPKB/ITPKA/INPP5F/PLCG2/PIK3C2B/PLCH1/MTMR2/PLCE1/SYNJ2/MTMR8/PI4K2B/PTEN/PLCD3/PIP4K2A/PLCD1/MTMR6/PI4KB	35
KEGG	hsa05014	Amyotrophic lateral sclerosis	151/2990	364/8135	0.03222	0.3711	0.3485	ND6/ATG101/BECN1/ANXA7/COX5B/TNF/ACTR10/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/DCTN1/NXF1/FUS/BAD/ND5/NDUFB3/SRSF7/NDUFB10/DCTN6/COX2/NDUFB6/NUP160/PSMA1/KLC4/NDUFV2/PFN3/UBQLN1/PSMA2/ULK2/NDUFA12/NDUFA2/ND2/ND4/ALS2/GPX6/ND1/PSMA6/HNRNPA2B1/NDUFC2/NUP85/PSMA5/SETX/FIG4/AMBRA1/NUP93/TANK/RAB39B/RAE1/UQCRFS1/PSMD1/COX4I1/CYTB/NUP107/NUP188/DNAH1/NDUFS4/ATXN2L/DCTN5/PSMB6/GLE1/PPP3CB/NDUFA6/DERL1/TP53/KIF5B/KLC3/UQCRC2/PPP3R1/NDUFS1/DNAL4/COX6A2/TUBA3E/CASP3/NDUFB5/SIGMAR1/COX5A/PSMD9/NDUFB1/PSMA4/NUP153/KLC1/MAP3K5/DNAH6/TNFRSF1B/MAP1LC3B2/PPP3CA/HSPA5/NUP50/PSMC1/EIF2S1/DNAI1/SLC1A2/PSMC4/NDUFB11/TUBB3/CHMP2B/NDUFAB1/KIF5A/UQCRQ/TNFRSF1A/ACTB/MAPK12/BCL2/PSMB5/PSMD7/PFN4/MAP2K3/NDUFV1/NUP133/NDUFA10/MAP1LC3C/SMCR8/COX7B/UBQLN4/ND3/UBQLN2/MATR3/TUBB2A/VAPB/CASP12/NRG2/DCTN2/PINK1/GPX2/RB1CC1/WIPI1/ATF6/MAPK11/PSMB7/NXT1/DNAH12/NOS1/POM121C/ADRM1/NUP98/MTOR/DCTN4/GPX7/APAF1/NEFH/UQCRC1/DNAH8/SDHC/SRSF3/TUBB/RAB5A/CHCHD10/ATF4	151
KEGG	hsa04120	Ubiquitin mediated proteolysis	63/2990	142/8135	0.03626	0.4037	0.3791	UBE2G1/PPIL2/UBE2Z/UBE2I/MDM2/FBXO2/KLHL9/PIAS3/UBA7/UBE2R2/DET1/UBE2M/UBA1/UBE2Q1/RBX1/NEDD4L/STUB1/PML/UBE2K/CUL2/UBE2J1/UBE3A/UBE2E3/CUL7/ANAPC7/SIAH1/BTRC/MAP3K1/TRAF6/NEDD4/CUL5/UBE2NL/CDC26/UBA52/FBXW11/UBE2H/CDC23/UBE2B/FANCL/SKP1/SAE1/UBE2D4/BIRC2/SMURF2/UBA2/UBE2L6/TRIM37/WWP2/CDC20/UBB/UBE2L3/UBE2A/HERC2/HERC1/UBE2D3/UBE2O/UBC/PIAS2/UBE3C/CUL3/FBXW8/UBE2E1/ITCH	63
KEGG	hsa04932	Non-alcoholic fatty liver disease	68/2990	155/8135	0.03934	0.4112	0.3862	PRKAB1/AKT2/IKBKB/COX5B/TNF/COX1/NDUFS3/COX6C/COX6B1/NDUFA9/NDUFB3/FASLG/NDUFB10/COX2/NDUFB6/NDUFV2/FOS/NDUFA12/NDUFA2/MAP3K11/IL6R/NDUFC2/GSK3B/PRKAB2/UQCRFS1/LEP/COX4I1/CYTB/NDUFS4/NDUFA6/PRKAG1/ADIPOR1/UQCRC2/SREBF1/NDUFS1/INS/JUN/COX6A2/CASP3/NDUFB5/AKT1/COX5A/NDUFB1/MAP3K5/RELA/EIF2S1/NDUFB11/NDUFAB1/UQCRQ/TNFRSF1A/MAPK12/PIK3R3/NDUFV1/NDUFA10/COX7B/MLXIPL/ADIPOR2/CASP8/CASP7/CYP2E1/MAPK10/IRS1/MAPK11/ITCH/UQCRC1/SDHC/CEBPA/ATF4	68
KEGG	hsa05210	Colorectal cancer	40/2990	86/8135	0.0394	0.4112	0.3862	AKT2/SMAD4/CTNNB1/BAD/BAK1/BBC3/FOS/GSK3B/GRB2/POLK/GADD45A/KRAS/SOS2/APC2/TP53/ARAF/JUN/RPS6KB1/CASP3/TCF7L2/AKT1/BRAF/CCND1/APPL1/CDKN1A/AREG/MSH2/RALA/NRAS/BCL2/TCF7/PIK3R3/SOS1/MAPK1/MAPK10/MSH6/MTOR/MAPK3/MSH3/GADD45G	40
KEGG	hsa04110	Cell cycle	56/2990	126/8135	0.04471	0.4447	0.4177	SMC1A/YWHAZ/SMAD4/RB1/MDM2/TFDP1/CCND2/STAG2/RBX1/CDC25B/GSK3B/MAD2L1/GADD45A/ANAPC7/WEE1/CHEK1/TP53/SMC3/YWHAE/CDC26/BUB1/MCM2/HDAC1/CDKN2C/CDC23/CCNE2/CDC45/CCND1/CDKN1A/SKP1/E2F2/CDKN2D/ORC1/YWHAB/CCNE1/CDKN2A/ORC3/TTK/MCM5/CDC20/CDC6/MCM4/TFDP2/CCNB3/CDK1/PLK1/ZBTB17/CDK7/MAD1L1/CCNA1/ORC6/CCNB2/MCM7/ATR/YWHAQ/GADD45G	56
KEGG	hsa04218	Cellular senescence	68/2990	156/8135	0.04527	0.4447	0.4177	AKT2/RB1/SLC25A4/LIN37/MDM2/MRAS/ZFP36L1/PPID/EIF4EBP1/CCND2/SIRT1/RAD9A/MYBL2/RRAS2/TSC1/NFATC1/CALML5/MAPKAPK2/FOXM1/GADD45A/KRAS/CHEK1/PPP3CB/BTRC/TP53/RASSF5/PPP3R1/FBXW11/PPP1CB/AKT1/HIPK1/HUS1/CCNE2/CCND1/FOXO3/CDKN1A/ZFP36L2/PPP3CA/E2F2/RELA/CCNE1/CDKN2A/RAD50/NRAS/MAPK12/VDAC2/MAP2K3/PIK3R3/RRAS/TRPV4/CALM1/CCNB3/MAPK1/RAD1/HIPK3/CDK1/HLA-C/MAPK11/IGFBP3/PTEN/CCNA1/CCNB2/MTOR/MAPK3/ATR/TSC2/ITPR1/GADD45G	68
KEGG	hsa01523	Antifolate resistance	16/2990	30/8135	0.04687	0.4473	0.4201	IKBKB/TNF/SLC46A1/CHUK/ABCC2/TYMS/MTHFR/FPGS/SHMT1/ABCC5/RELA/FOLR2/ABCC4/ATIC/ABCG2/FOLR3	16
KEGG	hsa05162	Measles	61/2990	139/8135	0.04861	0.4509	0.4235	AKT2/IKBKB/IL2RB/OAS2/IRF7/BAD/IKBKE/FASLG/MX1/STAT2/CCND2/BAK1/OAS3/MAVS/CHUK/STAT5A/OAS1/BBC3/FOS/RAB9B/IFNA21/NFKBIB/HSPA1L/GSK3B/EIF2AK1/IRF3/TP53/MX2/TRAF6/JUN/JAK3/IFIH1/CASP3/AKT1/CD28/CCNE2/IFNA2/CCND1/EIF2AK4/IFNA5/DDX58/TRADD/RELA/EIF2S1/CCNE1/SLAMF1/BCL2/PIK3R3/MSN/IRF9/CD3D/CSNK2B/CASP8/TRAF3/IFNA17/MAPK10/FADD/TNFAIP3/APAF1/HSPA6/IL2	61
KEGG	hsa05205	Proteoglycans in cancer	87/2990	205/8135	0.05183	0.4679	0.4394	AKT2/TNF/CTNNB1/MDM2/MRAS/FASLG/CAV1/VAV1/IGF1/RRAS2/PPP1R12C/PLCG1/ARHGEF1/PDPK1/PPP1R12A/GRB2/IHH/TIAM1/KRAS/TWIST1/SOS2/FZD9/ITGAV/TFAP4/THBS1/TP53/ARAF/PTPN6/ERBB2/ITGA5/RPS6KB1/PPP1CB/PDCD4/CASP3/HIF1A/AKT1/HGF/BRAF/LUM/WNT4/FZD6/FZD7/SDC1/CCND1/ANK1/CDKN1A/DDX5/SLC9A1/ESR1/PRKCB/RDX/GAB1/PLCG2/ANK3/ACTB/DCN/NRAS/MAPK12/CAMK2A/PLAU/PIK3R3/CTSL/COL1A2/RRAS/PXN/FN1/WNT10A/HCLS1/MSN/GPC1/SOS1/MIR10A/PLCE1/PTK2/FRS2/PRKACG/MAPK1/CAMK2D/ROCK2/MAPK11/COL1A1/WNT2/ARHGEF12/MTOR/MAPK3/WNT9B/ITPR1	87
KEGG	hsa03420	Nucleotide excision repair	23/2990	47/8135	0.05816	0.4902	0.4604	POLE4/GTF2H4/RFC1/RPA2/RBX1/CETN2/POLD3/XPC/ERCC2/POLE2/POLD2/ERCC1/RFC4/POLD4/ERCC3/XPA/RFC3/GTF2H5/RAD23B/ERCC4/RAD23A/CDK7/GTF2H1	23
KEGG	hsa01522	Endocrine resistance	44/2990	98/8135	0.05871	0.4902	0.4604	AKT2/RB1/MDM2/BAD/SP1/ADCY7/FOS/IGF1/SHC1/GRB2/KRAS/SOS2/TP53/ARAF/ERBB2/JUN/RPS6KB1/CARM1/AKT1/BRAF/CDKN2C/CCND1/CDKN1A/E2F2/ESR1/CDKN2A/GPER1/NRAS/MAPK12/BCL2/BIK/PIK3R3/ADCY4/SOS1/PTK2/PRKACG/NOTCH2/MAPK1/MAPK10/MAPK11/NOTCH1/MTOR/MAPK3/MED1	44
KEGG	hsa05231	Choline metabolism in cancer	44/2990	98/8135	0.05871	0.4902	0.4604	AKT2/SLC22A5/PCYT1A/SP1/EIF4EBP1/DGKZ/FOS/TSC1/PLCG1/PDPK1/PLD2/GPCPD1/DGKK/GRB2/KRAS/SOS2/WASF2/SLC44A1/JUN/RPS6KB1/HIF1A/AKT1/PIP5K1B/DGKA/PLA2G4C/PLA2G4D/PIP5K1A/SLC22A4/PDGFC/DGKH/PRKCB/LYPLA1/CHKA/NRAS/PIK3R3/SLC44A5/SOS1/MAPK1/WASF3/PDGFB/MAPK10/MTOR/MAPK3/TSC2	44
KEGG	hsa00600	Sphingolipid metabolism	25/2990	52/8135	0.06166	0.4966	0.4664	CERS5/ARSA/SGMS1/SPTLC1/PSAP/SMPD2/CERS4/KDSR/SPTLC3/SMPD4/DEGS1/GLA/GBA2/SGPP1/NEU1/CERS3/SGPP2/NEU4/B4GALT6/SGPL1/ACER1/SMPD1/NEU2/NEU3/SMPD3	25
KEGG	hsa04621	NOD-like receptor signaling pathway	78/2990	184/8135	0.06436	0.4966	0.4664	RIPK3/RNASEL/NLRP1/IKBKB/TNF/RNF31/P2RX7/OAS2/IRF7/IKBKE/RBCK1/STAT2/TAB1/OAS3/TP53BP1/MAVS/CHUK/OAS1/NOD2/PLCB2/IFNA21/DEFA6/GBP3/NFKBIB/TANK/TICAM1/IRF3/PSTPIP1/TAB3/TRAF6/GABARAPL2/HSP90AA1/YWHAE/DEFA5/JUN/PKN2/TXN2/TRIP6/HSP90AB1/IFNA2/IFNA5/MAP1LC3B2/ATG16L1/RELA/CASP5/BIRC2/GABARAP/NEK7/DNM1L/GABARAPL1/MAPK12/BCL2/VDAC2/TXN/MAP1LC3C/TRAF5/IRF9/CASP12/MFN1/CASP8/TRAF3/IFNA17/NOD1/MAPK1/MAPK10/FADD/MAPK11/CYBB/SUGT1/GBP1/CARD18/TNFAIP3/TRPV2/GSDMD/MAPK3/IFI16/ITPR1/PKN1	78
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/2990	11/8135	0.06464	0.4966	0.4664	COQ3/GGCX/COQ6/COQ2/COQ7/COQ5/VKORC1L1	7
KEGG	hsa05012	Parkinson disease	110/2990	266/8135	0.06542	0.4966	0.4664	ND6/UBE2G1/COX5B/SLC39A13/GNAI2/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/SLC25A4/ND5/UBA7/NDUFB3/NDUFB10/COX2/NDUFB6/PSMA1/KLC4/NDUFV2/UBA1/PSMA2/SLC39A1/PLCG1/NDUFA12/NDUFA2/ND2/SLC39A7/ND4/ND1/PSMA6/NDUFC2/UBE2J1/CALML5/PSMA5/UQCRFS1/PSMD1/COX4I1/SLC39A6/CYTB/NDUFS4/PSMB6/NDUFA6/TP53/KIF5B/KLC3/GNAL/UQCRC2/UBA52/NDUFS1/SLC39A2/COX6A2/TUBA3E/CASP3/NDUFB5/COX5A/PSMD9/TXN2/NDUFB1/PSMA4/KLC1/MAP3K5/HSPA5/PSMC1/EIF2S1/HTRA2/PSMC4/NDUFB11/DUSP1/MAOA/UBE2L6/TUBB3/NDUFAB1/KIF5A/UQCRQ/CAMK2A/VDAC2/TXN/PSMB5/SLC39A8/PSMD7/NDUFV1/UBB/NDUFA10/UBE2L3/COX7B/ND3/ADORA2A/SLC18A1/TUBB2A/PRKACG/CALM1/PINK1/MFN1/CAMK2D/MAPK10/UBC/SNCA/ATF6/PSMB7/SLC39A3/ADRM1/APAF1/UQCRC1/SDHC/TUBB/PARK7/ITPR1/ATF4	110
KEGG	hsa05165	Human papillomavirus infection	135/2990	331/8135	0.06818	0.5058	0.475	AKT2/TADA3/IKBKB/TNF/PPP2R2D/RB1/CHAD/CTNNB1/MDM2/LFNG/BAD/TCIRG1/DVL2/IKBKE/FASLG/EIF4EBP1/MX1/PTGER4/STAT2/CCND2/BAK1/DVL3/CHUK/COL4A4/TSC1/ITGA10/ITGB8/RBPJ/LLGL1/COL4A3/IFNA21/ATP6V1C2/MFNG/OASL/UBE3A/GSK3B/COL9A3/CHD4/GRB2/TICAM1/IRF3/KRAS/SOS2/FZD9/APC2/HES1/ITGAV/BCAP31/THBS1/TP53/DLG1/MX2/PPP2R5D/COL9A2/PPP2R2A/HES7/ATP6V1B1/ITGA5/RPS6KB1/PPP2R3B/CASP3/TCF7L2/AKT1/HDAC1/LAMB1/WNT4/PPP2R5A/COL6A1/FZD6/CCNE2/FZD7/IFNA2/CCND1/PPP2R5E/CDKN1A/ATP6V0E2/IFNA5/TRADD/HES3/RELA/PSMC1/CREB3L1/COL6A2/CCNE1/ATP6V1G3/CSNK1A1L/COL4A1/ATP6AP1/TNFRSF1A/NRAS/TCF7/ATP6V0B/PIK3R3/COL1A2/HES6/PXN/FN1/IBSP/TERT/WNT10A/CREB1/COL2A1/SOS1/IRF9/PTK2/COL9A1/PRKACG/COL4A5/NOTCH2/SLC9A3R1/ATP6V1A/CASP8/TRAF3/IFNA17/DLG2/MAPK1/HLA-C/TBPL1/FADD/NOTCH1/PTEN/ITGB7/LAMA3/COL1A1/PPP2R2C/CCNA1/CRB3/WNT2/MTOR/MAML3/MAPK3/WNT9B/CREB3L4/ATR/TSC2	135
KEGG	hsa04071	Sphingolipid signaling pathway	52/2990	119/8135	0.06966	0.5058	0.475	AKT2/CERS5/TNF/GNAI2/PPP2R2D/SGMS1/SPTLC1/PLCB2/SMPD2/CERS4/MS4A2/PDPK1/SPTLC3/PLD2/NOS3/FYN/KRAS/GNAQ/TP53/PPP2R5D/S1PR1/PPP2R2A/PPP2R3B/AKT1/DEGS1/S1PR5/PPP2R5A/MAP3K5/PPP2R5E/TRADD/SGPP1/CERS3/SGPP2/RELA/PRKCB/SGPL1/ACER1/TNFRSF1A/NRAS/MAPK12/FCER1A/BCL2/SMPD1/BDKRB2/PIK3R3/MAPK1/ROCK2/MAPK10/MAPK11/PTEN/PPP2R2C/MAPK3	52
KEGG	hsa03030	DNA replication	18/2990	36/8135	0.07137	0.5072	0.4764	POLE4/RFC1/RNASEH2C/RPA2/POLD3/PRIM1/POLE2/MCM2/POLA2/PRIM2/POLD2/DNA2/RFC4/POLD4/MCM5/RFC3/MCM4/MCM7	18
KEGG	hsa05135	Yersinia infection	59/2990	137/8135	0.07374	0.5131	0.4819	AKT2/IKBKB/TNF/WIPF1/TAB1/VAV1/CHUK/FOS/PLCG1/IL10/ARHGEF1/NFATC1/WIPF2/ARPC1B/GSK3B/TICAM1/IRF3/GNAQ/WASF2/ELMO2/BCAR1/TRAF6/DOCK1/ITGA5/JUN/AKT1/ARHGEF7/PKN2/PIP5K1B/PIP5K1A/RELA/LAT/ARPC5L/LCP2/ACTB/MAPK12/ARF6/WASL/MAP2K3/PIK3R3/PXN/FN1/CD8B/PTK2/ARPC1A/MAPK1/ROCK2/MAPK10/ACTR3B/ZAP70/RPS6KA3/SKAP2/MAPK11/ARHGEF12/GIT2/MAPK3/ARPC5/IL2/PKN1	59
KEGG	hsa00480	Glutathione metabolism	27/2990	58/8135	0.07971	0.5434	0.5103	GGT7/GPX6/MGST3/GSTA4/CHAC1/GSTK1/GGT5/CHAC2/GCLM/SMS/MGST1/TXNDC12/GSTA2/IDH1/PRDX6/LAP3/RRM2/ODC1/GPX2/GPX4/GSS/GSTA5/LANCL1/NAT8/GPX7/GSR/GSTM1	27
KEGG	hsa04962	Vasopressin-regulated water reabsorption	21/2990	44/8135	0.0888	0.5849	0.5493	DCTN1/DYNC2LI1/RAB11B/DCTN6/DYNLL1/DYNC1H1/DCTN5/DYNC1I1/RAB5C/STX4/CREB3L1/AQP3/CREB1/ARHGDIG/PRKACG/DCTN2/DCTN4/AVP/CREB3L4/RAB5A/RAB11A	21
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	189/2990	476/8135	0.09265	0.5849	0.5493	ND6/UBE2G1/ATG101/BECN1/COX5B/TNF/ACTR10/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/DCTN1/CSF1/FUS/SLC25A4/CTNNB1/BAD/PPID/ND5/DVL2/UBA7/NDUFB3/FASLG/NDUFB10/DCTN6/COX2/NDUFB6/BAK1/PSMA1/KLC4/DVL3/NDUFV2/UBA1/PSMA2/ULK2/PLCG1/PLCB2/NDUFA12/NDUFA2/ND2/ND4/ALS2/GPX6/ND1/PSMA6/CHRM3/NDUFC2/UBE2J1/CALML5/PSMA5/FIG4/GSK3B/AMBRA1/TANK/RAB39B/UQCRFS1/PSMD1/COX4I1/KRAS/FZD9/APC2/GNAQ/CYTB/DNAH1/NDUFS4/ATXN2L/DCTN5/AGER/PSMB6/PPP3CB/NDUFA6/DERL1/KIF5B/KLC3/ARAF/UQCRC2/PPP3R1/UBA52/NDUFS1/DNAL4/CHRNA7/COX6A2/TUBA3E/CASP3/NDUFB5/SIGMAR1/COX5A/PSMD9/BRAF/NDUFB1/WNT4/PSMA4/SPTBN2/KLC1/FZD6/MAP3K5/FZD7/DNAH6/DKK2/TNFRSF1B/MAP1LC3B2/PPP3CA/HSPA5/HIP1/RELA/PSMC1/EIF2S1/DNAI1/HTRA2/PRKCB/PSMC4/NDUFB11/UBE2L6/ATXN3/TUBB3/CSNK1A1L/CHMP2B/NDUFAB1/KIF5A/UQCRQ/TNFRSF1A/NRAS/MAPK12/BCL2/CAMK2A/VDAC2/LRP6/PSMB5/PSMD7/TRPC3/MAP2K3/NDUFV1/UBB/NDUFA10/MAP1LC3C/UBE2L3/SMCR8/WNT10A/COX7B/ND3/CHRM5/TUBB2A/VAPB/CSNK2B/CASP12/DCTN2/CALM1/PINK1/MFN1/CASP8/MAPK1/GPX2/CAMK2D/CACNA1F/RB1CC1/CASP7/WIPI1/MAPK10/UBC/SNCA/ATF6/FADD/MAPK11/PSMB7/PRNP/DNAH12/CYBB/NOS1/STX1A/ADRM1/WNT2/MTOR/DCTN4/GPX7/APAF1/NEFH/CACNA1C/MAPK3/UQCRC1/DNAH8/SDHC/WNT9B/TUBB/PARK7/RAB5A/ITPR1/ATF4	189
KEGG	hsa03060	Protein export	12/2990	23/8135	0.09515	0.5849	0.5493	SRP72/SRPRB/SEC11C/SEC11A/SRP68/SPCS2/SRP54/SRP19/HSPA5/SEC61A1/SEC62/SEC61G	12
KEGG	hsa03430	Mismatch repair	12/2990	23/8135	0.09515	0.5849	0.5493	MLH3/RFC1/RPA2/POLD3/EXO1/MSH2/POLD2/RFC4/POLD4/RFC3/MSH6/MSH3	12
KEGG	hsa04064	NF-kappa B signaling pathway	45/2990	104/8135	0.1003	0.5849	0.5493	IKBKB/TNF/UBE2I/EDA/TIRAP/CARD10/MAP3K14/TAB1/CHUK/PLCG1/PIDD1/TICAM1/GADD45A/TRAF1/TAB3/ERC1/TRAF6/NFKB2/EDAR/LTA/EDA2R/DDX58/TRADD/RELA/BIRC2/CD40/PRKCB/LAT/PLCG2/TNFRSF1A/BCL2/PLAU/LTBR/TRAF5/CSNK2B/TRAF3/ZAP70/LY96/BTK/TNFAIP3/CARD14/LYN/CARD11/TRIM25/GADD45G	45
KEGG	hsa04625	C-type lectin receptor signaling pathway	45/2990	104/8135	0.1003	0.5849	0.5493	AKT2/IL23A/IKBKB/TNF/MDM2/MRAS/IKBKE/STAT2/MAP3K14/CHUK/RRAS2/IL10/NFATC1/CALML5/MAPKAPK2/KRAS/KSR1/PPP3CB/NFKB2/LSP1/PPP3R1/JUN/CCL17/CLEC6A/AKT1/PPP3CA/RELA/PLCG2/NRAS/MAPK12/IL17D/PIK3R3/RRAS/IRF9/EGR2/CALM1/CASP8/MAPK1/MAPK10/MAPK11/ARHGEF12/MAPK3/CCL22/IL2/ITPR1	45
KEGG	hsa04660	T cell receptor signaling pathway	45/2990	104/8135	0.1003	0.5849	0.5493	AKT2/IKBKB/TNF/MAP3K14/VAV1/CHUK/FOS/PLCG1/IL10/NFATC1/PDPK1/NFKBIB/GSK3B/FYN/GRB2/KRAS/SOS2/PPP3CB/GRAP2/DLG1/PTPN6/PPP3R1/JUN/MAP3K8/IL4/AKT1/NCK2/CD28/PPP3CA/RELA/LAT/LCP2/NRAS/MAPK12/PIK3R3/SOS1/CD8B/CD3D/MAPK1/MAPK10/ZAP70/MAPK11/MAPK3/CARD11/IL2	45
KEGG	hsa04936	Alcoholic liver disease	60/2990	142/8135	0.1004	0.5849	0.5493	PRKAB1/AKT2/TRA2A/IKBKB/TNF/TIRAP/CTNNB1/IKBKE/FASLG/MAP3K14/TAB1/SIRT1/CHUK/C3/ACOX3/IFNA21/MLYCD/GSK3B/PRKAB2/TICAM1/IRF3/LPIN3/TAB3/TRAF6/PRKAG1/ADIPOR1/SREBF1/CASP3/TCF7L2/AKT1/MAP3K5/IFNA2/CCND1/ACADVL/FOXO3/IFNA5/TRADD/RELA/CPT1C/CPT1A/ADH1A/TNFRSF1A/MAPK12/TCF7/MAP2K3/LPIN1/ADIPOR2/CASP8/TRAF3/IFNA17/CYP2E1/MAPK10/FADD/MAPK11/LY96/FABP1/IL17A/C1QC/C1QA/ADH4	60
KEGG	hsa04714	Thermogenesis	95/2990	232/8135	0.1017	0.5849	0.5493	ND6/PRKAB1/COX15/COX5B/COX1/NDUFS3/COX6C/COX6B1/NDUFA9/COA1/ND5/SMARCB1/NDUFB3/NDUFB10/COX2/NDUFB6/COX17/NDUFV2/NDUFAF1/ADCY7/TSC1/NDUFA12/NDUFA2/ND2/ND4/NDUFAF4/SLC25A20/NDUFAF3/ND1/COA5/NDUFC2/PRKAB2/GRB2/UQCRFS1/COX4I1/KRAS/SOS2/CYTB/NDUFS4/NDUFA6/PRKAG1/UQCRC2/NDUFS1/RPS6KB1/COX6A2/NDUFB5/COX5A/NDUFB1/MAP3K5/SMARCD2/CREB3L1/NDUFB11/CPT1C/CPT1A/COX18/NDUFAB1/COX10/COX14/UQCRQ/ACTB/PRDM16/NRAS/MAPK12/SMARCA2/CPT2/ARID1A/MAP2K3/NDUFV1/NDUFA10/COX7B/ND3/ADCY4/CREB1/SOS1/PNPLA2/FRS2/SIRT6/PRKACG/NPPB/NDUFAF6/ADRB3/RPS6KA3/COX20/MAPK11/NDUFAF5/ACSL3/FGF21/MTOR/ATF2/SMARCD1/UQCRC1/SDHC/ARID1B/CREB3L4/TSC2	95
KEGG	hsa04934	Cushing syndrome	65/2990	155/8135	0.1033	0.5849	0.5493	RBBP5/RAP1A/GNAI2/RB1/MEN1/CTNNB1/DVL2/SP1/DVL3/ADCY7/ORAI1/AGTR1/PLCB2/ATF6B/KMT2D/PDE8B/RAP1B/GSK3B/AHR/FZD9/APC2/GNAQ/WDR5B/TCF7L2/BRAF/CDKN2C/WNT4/FZD6/PDE8A/CCNE2/FZD7/CCND1/CDKN1A/CACNA1I/FH/E2F2/CREB3L1/CCNE1/CDKN2A/USP8/CAMK2A/TCF7/WNT10A/ADCY4/CREB1/CACNA1G/PRKACG/MAPK1/CAMK2D/CACNA1F/POMC/ASH2L/WNT2/CACNA1C/MAPK3/ATF2/WNT9B/NR4A1/CREB3L4/AGT/SCARB1/CYP21A2/ITPR1/MC2R/ATF4	65
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	80/2990	194/8135	0.1089	0.5877	0.5519	AKT2/BECN1/IKBKB/RB1/CTNNB1/IRF7/IKBKE/STAT2/BAK1/CHUK/C3/FOS/PLCG1/IFNA21/ATG3/NFATC1/CD200R1L/CALML5/GSK3B/CCR3/CCR4/TICAM1/MAPKAPK2/IRF3/KRAS/PPP3CB/GNG7/TP53/GNG5/PIK3R6/PPP3R1/UBA52/JUN/CASP3/TCF7L2/HIF1A/AKT1/IFNA2/CCND1/CDKN1A/GNB1/IFNA5/MAP1LC3B2/TRADD/PPP3CA/E2F2/RELA/PIK3R5/PLCG2/CCR8/TNFRSF1A/NRAS/MAPK12/TCF7/GNG11/PIK3R3/UBB/MAP1LC3C/CLEC2B/CREB1/IRF9/CALM1/CASP8/TRAF3/IFNA17/MAPK1/PDGFB/MAPK10/HLA-C/UBC/FADD/CD200R1/MAPK11/GNGT1/MTOR/MAPK3/CCR1/LYN/ANGPT2/ITPR1	80
KEGG	hsa05218	Melanoma	32/2990	72/8135	0.109	0.5877	0.5519	AKT2/RB1/MDM2/BAD/BAK1/IGF1/FGF3/POLK/GADD45A/KRAS/TP53/ARAF/AKT1/HGF/BRAF/CCND1/CDKN1A/CDH1/FGF6/PDGFC/E2F2/FGF20/CDKN2A/NRAS/PIK3R3/MAPK1/PDGFB/FGF23/PTEN/FGF21/MAPK3/GADD45G	32
KEGG	hsa05169	Epstein-Barr virus infection	83/2990	202/8135	0.1117	0.5877	0.5519	AKT2/IKBKB/TNF/RB1/MDM2/OAS2/IRF7/IKBKE/STAT2/MAP3K14/TAB1/CCND2/BAK1/OAS3/MAVS/CHUK/OAS1/RBPJ/IFNA21/NFKBIB/PSMD1/POLK/IRF3/GADD45A/HES1/FCER2/TP53/TRAF6/NFKB2/NEDD4/JUN/JAK3/CASP3/AKT1/HDAC1/CCNE2/CXCL10/IFNA2/CCND1/CDKN1A/IFNA5/DDX58/TRADD/E2F2/CALR/RELA/PSMC1/TAP1/CD40/CCNE1/PSMC4/PLCG2/B2M/HLA-DRA/MAPK12/BCL2/PSMD7/MAP2K3/PIK3R3/HLA-DMB/CIR1/TRAF5/IRF9/ENTPD1/CD3D/CASP8/NCOR2/TAP2/TRAF3/IFNA17/MAPK10/HLA-C/FADD/MAPK11/BTK/ITGAL/ADRM1/CCNA1/TNFAIP3/APAF1/LYN/CR2/GADD45G	83
KEGG	hsa04130	SNARE interactions in vesicular transport	16/2990	33/8135	0.1124	0.5877	0.5519	BET1/VAMP7/STX5/STX17/YKT6/VAMP1/STX1B/STX4/STX6/GOSR2/BET1L/GOSR1/SNAP23/STX11/STX16/STX1A	16
KEGG	hsa05417	Lipid and atherosclerosis	88/2990	215/8135	0.1126	0.5877	0.5519	AKT2/RAP1A/IKBKB/TNF/TIRAP/IRF7/BAD/IKBKE/FASLG/TAB1/VAV1/CHUK/FOS/POU2F2/PLCG1/PLCB2/IFNA21/TNFRSF10B/ARHGEF1/NFATC1/PDPK1/TNFRSF10A/HSPA1L/CALML5/RAP1B/GSK3B/NOS3/TANK/TICAM1/IRF3/KRAS/CYP2C9/AGER/PPP3CB/TP53/TRAF6/MIB2/HSPD1/HSP90AA1/PPP3R1/JUN/CASP3/AKT1/APOA1/CASP6/MAP3K5/HSP90AB1/IFNA2/TNFSF10/IFNA5/PPP3CA/HSPA5/RELA/EIF2S1/CD40/TNFRSF1A/NRAS/MAPK12/RXRB/BCL2/CAMK2A/MAP2K3/PIK3R3/HSP90B1/PTK2/CALM1/CASP8/TRAF3/IFNA17/CYP2C8/MAPK1/CAMK2D/CASP7/ROCK2/MAPK10/ATF6/MAPK11/LY96/CYBB/MIB1/APAF1/MAPK3/ABCA1/ABCG1/HSPA6/LYN/ITPR1/ATF4	88
KEGG	hsa04010	MAPK signaling pathway	118/2990	294/8135	0.1227	0.6246	0.5866	AKT2/RAP1A/IKBKB/TNF/CSF1/TAOK2/MAP3K2/MRAS/EPHA2/FASLG/CACNB1/MAP3K14/TAB1/CHUK/FOS/IGF1/RRAS2/FGFR2/MAP3K11/FGF3/NFATC1/PPM1A/DUSP6/CDC25B/HSPA1L/FLT3LG/RAP1B/MAPK8IP3/GRB2/MAPKAPK2/MAPKAPK3/GADD45A/KRAS/EFNA3/SOS2/PPP3CB/TP53/MAP3K1/TRAF6/ARAF/FGFR4/NFKB2/CSF1R/DUSP7/PPP3R1/ERBB2/INS/JUN/MAP3K8/CASP3/RAPGEF2/AKT1/HGF/ARRB1/BRAF/MAP4K3/VEGFC/STMN1/MAP3K5/PLA2G4C/MAP2K5/PLA2G4D/AREG/CACNA1I/FGF6/TRADD/PPP3CA/PDGFC/RELA/FGF20/NGF/PRKCB/TAOK1/DUSP1/FLT3/CACNG4/CACNG6/MAP3K13/TNFRSF1A/NRAS/MAP3K12/MAPK12/EFNA2/RASGRF2/MAP2K3/CACNB3/RRAS/MAPKAPK5/SRF/CACNA2D2/SOS1/ARRB2/CACNA1G/PRKACG/DUSP4/MAPK1/CACNA1F/DUSP10/MAP3K6/PDGFB/MAPK10/RPS6KA3/MAP4K2/PGF/FGF23/RPS6KA4/MAPK11/NTRK2/FGF21/CACNA1C/NGFR/MAPK3/ATF2/NR4A1/HSPA6/ANGPT2/GADD45G/ATF4	118
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	55/2990	131/8135	0.1234	0.6246	0.5866	SH2D1B/TNF/CD48/FASLG/VAV1/SH3BP2/NCR1/PLCG1/SHC1/ULBP2/IFNA21/TNFRSF10B/CD244/NFATC1/TNFRSF10A/NCR3/FYN/GRB2/FCGR3A/KRAS/SOS2/PPP3CB/ARAF/PTPN6/PPP3R1/CASP3/KIR2DS4/BRAF/KLRD1/IFNA2/TNFSF10/PRF1/IFNA5/PPP3CA/KIR2DS1/PRKCB/KIR2DS2/LAT/PLCG2/LCP2/NRAS/PIK3R3/KIR3DL2/SOS1/ITGB2/KIR3DL3/IFNA17/MAPK1/ZAP70/HLA-C/GZMB/ITGAL/ICAM2/KIR2DL1/MAPK3	55
KEGG	hsa03040	Spliceosome	61/2990	147/8135	0.1323	0.6389	0.6	PHF5A/TRA2A/SRSF5/RNU5A-1/SMNDC1/EIF4A3/CHERP/LSM5/DHX16/FUS/LSM3/DDX23/SRSF7/U2AF2/DDX39B/PRPF38A/TXNL4A/PRPF4/SF3B3/SF3B6/USP39/DDX42/SF3B2/HSPA1L/RBM8A/SNRPD3/SF3B1/PRPF18/SRSF6/THOC3/PRPF31/PRPF38B/SRSF4/SART1/ACIN1/DHX15/PQBP1/BUD31/CDC5L/SRSF9/DHX8/DDX5/RBM17/SRSF1/SRSF2/MAGOHB/PPIH/SF3A3/SNRNP70/SF3B4/SNRPB/THOC2/NCBP2/SLU7/DHX38/WBP11/MAGOH/SNRPD1/SRSF3/PPIE/HSPA6	61
KEGG	hsa05163	Human cytomegalovirus infection	91/2990	225/8135	0.1372	0.6389	0.6	AKT2/IKBKB/TNF/GNAI2/RB1/CTNNB1/PTGER2/MDM2/FASLG/SP1/EIF4EBP1/PTGER4/BAK1/CHUK/ADCY7/TSC1/PLCB2/ATF6B/IL6R/IFNA21/ARHGEF1/NFATC1/CALML5/GSK3B/CCR3/GRB2/IRF3/KRAS/SOS2/GNAQ/ITGAV/PPP3CB/GNG7/TP53/GNG5/BCAR1/PPP3R1/RPS6KB1/CASP3/IL10RB/AKT1/IFNA2/CCND1/CDKN1A/GNB1/IFNA5/TRADD/PPP3CA/AKAP13/E2F2/CALR/RELA/IL10RA/TAP1/CREB3L1/PRKCB/CDKN2A/B2M/PTGER1/TNFRSF1A/NRAS/MAPK12/ARHGEF11/GNG11/PIK3R3/PXN/ADCY4/CREB1/TRAF5/SOS1/PTK2/PRKACG/CALM1/CASP8/TAP2/IFNA17/MAPK1/ROCK2/HLA-C/FADD/MAPK11/GNGT1/ARHGEF12/MTOR/MAPK3/ATF2/CCR1/CREB3L4/TSC2/ITPR1/ATF4	91
KEGG	hsa04340	Hedgehog signaling pathway	25/2990	56/8135	0.1383	0.6389	0.6	CSNK1G2/SUFU/CCND2/EFCAB7/KIF7/CSNK1D/GSK3B/IHH/BTRC/FBXW11/ARRB1/CSNK1G3/DISP1/GAS1/CCND1/GLI2/SMURF2/CSNK1A1L/BCL2/ARRB2/PTCH2/PRKACG/KIF3A/CUL3/IQCE	25
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	62/2990	150/8135	0.1384	0.6389	0.6	AKT2/GNAI2/PPP2R2D/CACNB1/PLN/ADCY7/AGTR1/PLCB2/ATF6B/TNNI3/CALML5/MYH6/GNAQ/TPM3/PPP2R5D/MYL4/ATP1A4/PIK3R6/PPP2R2A/PPP1CB/PPP2R3B/AKT1/PPP2R5A/AGTR2/MYL2/TPM1/ADRB2/PPP2R5E/ADRA1D/ATP2B3/SLC9A1/CREB3L1/PIK3R5/ATP1B2/CACNG4/CACNG6/ATP2B2/MAPK12/BCL2/CAMK2A/ATP1A1/CACNB3/ADCY4/CREB1/CACNA2D2/PRKACG/CALM1/SCN5A/MAPK1/CAMK2D/CACNA1F/TNNT2/SCN4B/MAPK11/PPP2R2C/CACNA1C/MAPK3/ATF2/CREB3L4/AGT/TPM4/ATF4	62
KEGG	hsa03020	RNA polymerase	16/2990	34/8135	0.1425	0.6389	0.6	POLR2H/POLR2K/POLR1A/POLR1D/POLR2G/POLR1C/POLR3A/POLR3K/CRCP/CD3EAP/POLR3GL/POLR3H/POLR1E/POLR1B/POLR2B/POLR2J	16
KEGG	hsa00900	Terpenoid backbone biosynthesis	11/2990	22/8135	0.1429	0.6389	0.6	FNTA/PCYOX1/HMGCR/RCE1/ICMT/NUS1/PMVK/DHDDS/HMGCS1/GGPS1/ACAT1	11
KEGG	hsa04151	PI3K-Akt signaling pathway	140/2990	354/8135	0.1451	0.6389	0.6	AKT2/IKBKB/YWHAZ/PPP2R2D/CSF1/CHAD/EIF4E2/IL2RB/MDM2/BAD/EPHA2/FASLG/EIF4EBP1/CCND2/CHUK/COL4A4/IGF1/FGFR2/TSC1/IL4R/ITGA10/ATF6B/ITGB8/IL6R/FGF3/COL4A3/IFNA21/PDPK1/FLT3LG/GSK3B/COL9A3/NOS3/GRB2/KRAS/EFNA3/SOS2/ITGAV/THBS1/GNG7/TP53/GNG5/PPP2R5D/PIK3R6/FGFR4/COL9A2/HSP90AA1/CSF1R/YWHAE/SGK1/PPP2R2A/ERBB2/IL7/ITGA5/INS/RPS6KB1/JAK3/PPP2R3B/IL4/AKT1/PKN2/HGF/LAMB1/VEGFC/PPP2R5A/COL6A1/CCNE2/HSP90AB1/IFNA2/CCND1/PPP2R5E/FOXO3/CDKN1A/GNB1/AREG/IFNA5/FGF6/LPAR2/PDGFC/RELA/PCK2/EPOR/FGF20/CREB3L1/NGF/COL6A2/YWHAB/CCNE1/PIK3R5/FLT3/COL4A1/TCL1A/NRAS/EFNA2/BCL2/GNG11/PIK3R3/LPAR5/COL1A2/FN1/IBSP/HSP90B1/CREB1/COL2A1/SOS1/MCL1/PTK2/COL9A1/COL4A5/IFNA17/MAPK1/PIK3AP1/PDGFB/IRS1/PGF/FGF23/NTRK2/CDC37/IL3RA/PTEN/ITGB7/LAMA3/COL1A1/PPP2R2C/GNGT1/FGF21/MTOR/PRLR/NGFR/MAPK3/ATF2/NR4A1/OSM/CREB3L4/G6PC3/ANGPT2/IL2/YWHAQ/TSC2/PKN1/ATF4	140
KEGG	hsa04211	Longevity regulating pathway	38/2990	89/8135	0.1451	0.6389	0.6	ATG101/PRKAB1/AKT2/EIF4E2/EIF4EBP1/SIRT1/ADCY7/IGF1/TSC1/ATF6B/EHMT2/PRKAB2/KRAS/TP53/PRKAG1/ADIPOR1/INS/RPS6KB1/AKT1/APPL1/FOXO3/RELA/CREB3L1/SESN2/NRAS/PIK3R3/ADCY4/CREB1/ADIPOR2/PRKACG/RB1CC1/IRS1/KL/MTOR/ATF2/CREB3L4/TSC2/ATF4	38
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	34/2990	79/8135	0.1478	0.6389	0.6	AKT2/EIF4E2/BAD/EIF4EBP1/IGF1/FGFR2/PLCG1/IL6R/SHC1/GSK3B/GRB2/KRAS/SOS2/ARAF/ERBB2/RPS6KB1/AKT1/HGF/BRAF/FOXO3/PDGFC/PRKCB/GAB1/PLCG2/NRAS/BCL2/PIK3R3/SOS1/NRG2/MAPK1/PDGFB/PTEN/MTOR/MAPK3	34
KEGG	hsa03460	Fanconi anemia pathway	24/2990	54/8135	0.1506	0.6389	0.6	PALB2/FANCE/TOP3B/RPA2/TOP3A/ATRIP/BRIP1/POLK/RMI1/HES1/RAD51C/REV1/FANCL/SLX4/POLI/ERCC1/RMI2/POLH/ERCC4/FANCA/BRCA2/EME1/FANCB/ATR	24
KEGG	hsa05222	Small cell lung cancer	39/2990	92/8135	0.1541	0.6389	0.6	AKT2/IKBKB/RB1/FHIT/BAK1/CHUK/COL4A4/COL4A3/POLK/GADD45A/TRAF1/ITGAV/TP53/TRAF6/CASP3/AKT1/LAMB1/CKS1B/CCNE2/CCND1/CDKN1A/E2F2/RELA/BIRC2/CCNE1/COL4A1/RXRB/BCL2/PIK3R3/FN1/TRAF5/PTK2/COL4A5/TRAF3/ZBTB17/PTEN/LAMA3/APAF1/GADD45G	39
KEGG	hsa04215	Apoptosis - multiple species	15/2990	32/8135	0.1571	0.6389	0.6	BECN1/DIABLO/BAK1/BBC3/CASP3/BIRC2/HTRA2/TNFRSF1A/BCL2/CASP8/CASP7/MAPK10/FADD/APAF1/NGFR	15
KEGG	hsa04146	Peroxisome	35/2990	82/8135	0.1577	0.6389	0.6	PEX12/PRDX1/PEX11B/PEX26/PEX19/PEX14/SCP2/PEX5/HMGCL/ACOX3/MLYCD/NUDT7/PEX11G/SLC25A17/ABCD4/PEX13/PMVK/GSTK1/PRDX5/EHHADH/PEX11A/PXMP4/IDH1/ACAA1/PHYH/PEX16/PEX1/PEX7/ECI2/PEX2/ABCD1/ACSL3/CRAT/PECR/AGXT	35
KEGG	hsa04140	Autophagy - animal	58/2990	141/8135	0.1586	0.6389	0.6	RAB7A/ATG101/AKT2/BECN1/RAB33B/STX17/BAD/MRAS/RRAGB/MTMR4/HMGB1/ULK2/RRAS2/TSC1/ATG3/PDPK1/AMBRA1/TANK/RAB39B/KRAS/ATG4C/TRAF6/GABARAPL2/VMP1/INS/RPS6KB1/HIF1A/AKT1/EIF2AK4/MAP1LC3B2/ATG16L1/EIF2S1/ATG4A/GABARAP/ATG16L2/PRAP1/GABARAPL1/ATG4B/NRAS/BCL2/PIK3R3/CTSL/RRAS/MAP1LC3C/SMCR8/PRKACG/MAPK1/RB1CC1/WIPI1/MAPK10/IRS1/ATG9B/PTEN/RRAGD/MTOR/MAPK3/TSC2/ITPR1	58
KEGG	hsa05171	Coronavirus disease - COVID-19	93/2990	232/8135	0.1589	0.6389	0.6	RPL26/RPL19/RPL21/RPL30/IKBKB/TNF/RPL36AL/RPL36A-HNRNPH2/OAS2/RSL24D1/IKBKE/MX1/STAT2/RPL23A/RPS15A/OAS3/RPLP0/MAVS/CHUK/OAS1/RPS8/RPS24/C3/FOS/RPS27/AGTR1/PLCG1/RPL10A/RPL24/IL6R/RPL12/IFNA21/RPSA/RPS7/NFKBIB/RPS19/RPL18A/RPL41/RPLP2/RPL6/RPS11/IRF3/RPS4Y1/RPL27/RPS13/MX2/TRAF6/RPL10L/RPS10/UBA52/RPL5/JUN/RPL11/IFIH1/RPL39/RPL15/FAU/CXCL10/IFNA2/IFNA5/DDX58/RPS18/RELA/RPS5/RPS20/RPL38/PRKCB/RPS27L/PLCG2/RPL3/TNFRSF1A/MAPK12/RPS4Y2/PIK3R3/RPL35/RPL37/IRF9/C8G/TRAF3/IFNA17/MAPK1/MAPK10/RPL23/RPL37A/RPS12/MAPK11/CYBB/RPS17/RPL35A/C1QC/MAPK3/IL2/C1QA	93
KEGG	hsa00670	One carbon pool by folate	10/2990	20/8135	0.159	0.6389	0.6	MTR/TYMS/MTHFD2/MTHFR/SHMT1/FTCD/ATIC/MTHFD1L/MTHFD1/MTFMT	10
KEGG	hsa03450	Non-homologous end-joining	7/2990	13/8135	0.1605	0.6389	0.6	POLM/LIG4/XRCC4/DCLRE1C/NHEJ1/RAD50/XRCC5	7
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	42/2990	100/8135	0.1609	0.6389	0.6	AKT2/TNF/SMAD4/EGR1/COL4A4/STAT5A/AGTR1/PLCG1/PLCB2/COL4A3/NFATC1/PLCD4/NOS3/F3/KRAS/AGER/JUN/CASP3/AKT1/VEGFC/CCND1/RELA/PRKCB/PLCG2/COL4A1/NRAS/MAPK12/BCL2/PIK3R3/COL1A2/FN1/PLCE1/COL4A5/MAPK1/MAPK10/MAPK11/CYBB/COL1A1/PLCD3/MAPK3/PLCD1/AGT	42
KEGG	hsa05226	Gastric cancer	61/2990	149/8135	0.1626	0.6389	0.6	AKT2/SMAD4/RB1/CTNNB1/DVL2/BAK1/DVL3/FGFR2/SHC1/FGF3/GSK3B/GRB2/POLK/GADD45A/KRAS/SOS2/FZD9/APC2/TP53/ARAF/ERBB2/RPS6KB1/TCF7L2/AKT1/HGF/BRAF/WNT4/FZD6/CCNE2/FZD7/CCND1/CDKN1A/CDH1/FGF6/E2F2/FGF20/CCNE1/GAB1/CSNK1A1L/NRAS/RXRB/BCL2/TCF7/JUP/LRP6/PIK3R3/ABCB1/TERT/WNT10A/SOS1/CTNNA2/MAPK1/CTNNA1/FGF23/CTNNA3/FGF21/WNT2/MTOR/MAPK3/WNT9B/GADD45G	61
KEGG	hsa04919	Thyroid hormone signaling pathway	50/2990	121/8135	0.1696	0.6587	0.6187	AKT2/CTNNB1/MDM2/BAD/PLN/PLCG1/PLCB2/MED12/PDPK1/PLCD4/GSK3B/MYH6/KRAS/ITGAV/TP53/ATP1A4/HIF1A/AKT1/HDAC1/WNT4/CCND1/SLC9A1/MED14/ESR1/PRKCB/MED24/ATP1B2/PLCG2/SLC16A2/MED13L/HDAC3/ACTB/NRAS/RXRB/ATP1A1/PIK3R3/MED30/PLCE1/MED16/PRKACG/NOTCH2/MAPK1/KAT2B/NOTCH1/PLCD3/MTOR/MAPK3/PLCD1/TSC2/MED1	50
KEGG	hsa05225	Hepatocellular carcinoma	68/2990	168/8135	0.1759	0.6754	0.6343	AKT2/SMAD4/RB1/CTNNB1/BAD/TXNRD2/DVL2/SMARCB1/BAK1/DVL3/ARID2/PLCG1/SHC1/MGST3/GSK3B/GRB2/POLK/GSTA4/GADD45A/KRAS/SOS2/FZD9/APC2/TP53/ARAF/PBRM1/RPS6KB1/TCF7L2/AKT1/HGF/BRAF/WNT4/FZD6/FZD7/CCND1/HMOX1/CDKN1A/MGST1/E2F2/GSTA2/SMARCD2/PRKCB/GAB1/CDKN2A/PLCG2/CSNK1A1L/ACTB/NRAS/SMARCA2/TCF7/LRP6/ARID1A/PIK3R3/TERT/WNT10A/SOS1/MAPK1/GSTA5/TXNRD1/PTEN/WNT2/MTOR/MAPK3/SMARCD1/WNT9B/ARID1B/GSTM1/GADD45G	68
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	44/2990	106/8135	0.1783	0.6767	0.6355	GNAI2/SP1/EGR1/ADCY7/FOS/PLCB2/ATF6B/ARHGEF1/PLD2/PDE4D/MEF2D/CYP27B1/GNAQ/ARAF/MMP24/ARRB1/BRAF/BGLAP/GCM2/CDKN1A/AKAP13/CREB3L1/PRKCB/RXRB/BCL2/ARHGEF11/LRP6/RUNX2/ADCY4/CREB1/ARRB2/PRKACG/SLC9A3R1/MAPK1/VDR/MMP14/FGF23/KL/MAPK3/ATF2/CREB3L4/PDE4C/ITPR1/ATF4	44
KEGG	hsa03010	Ribosome	64/2990	158/8135	0.1826	0.6851	0.6434	RPL26/MRPL27/RPL19/MRPS5/RPL21/RPL30/MRPS2/RPL36AL/RPL36A-HNRNPH2/RSL24D1/RPL23A/RPS15A/RPLP0/MRPL21/RPS8/RPS24/RPS27/MRPL22/RPL10A/RPL24/RPL12/RPSA/RPS7/RPS19/RPL18A/RPL41/RPLP2/RPL6/RPS11/MRPL18/RPS4Y1/RPL27/RPS13/RPL10L/RPS10/UBA52/RPL5/RPL11/RPL39/RPL15/FAU/RPS18/RPS5/RPS20/RPL38/RPS27L/RPL3/MRPL23/RPS4Y2/MRPL9/RPL35/MRPS12/RPL37/MRPS14/MRPL33/MRPS15/RPL23/MRPL16/MRPS18A/RPL37A/RPS12/RPS17/RPL35A/MRPL4	64
KEGG	hsa04664	Fc epsilon RI signaling pathway	29/2990	68/8135	0.1873	0.695	0.6527	AKT2/TNF/VAV1/PLCG1/MS4A2/PDPK1/FYN/GRB2/KRAS/SOS2/IL4/AKT1/PLA2G4C/PLA2G4D/LAT/PLCG2/LCP2/NRAS/MAPK12/FCER1A/MAP2K3/PIK3R3/SOS1/MAPK1/MAPK10/MAPK11/BTK/MAPK3/LYN	29
KEGG	hsa04150	mTOR signaling pathway	63/2990	156/8135	0.1929	0.7079	0.6648	AKT2/IKBKB/TNF/EIF4E2/DVL2/RRAGB/EIF4EBP1/DVL3/CHUK/IGF1/ULK2/TSC1/PRR5L/STRADA/ATP6V1C2/PDPK1/FLCN/GSK3B/GRB2/KRAS/SOS2/FZD9/LPIN3/WDR59/TTI1/LAMTOR2/SGK1/ATP6V1B1/SLC7A5/INS/RPS6KB1/AKT1/BRAF/WNT4/FNIP2/FZD6/FZD7/MAPKAP1/STRADB/SESN2/PRKCB/ATP6V1G3/TNFRSF1A/NRAS/LRP6/PIK3R3/WNT10A/SOS1/LPIN1/ATP6V1A/MAPK1/IRS1/RPS6KA3/PTEN/WNT2/RRAGD/MTOR/MAPK3/NPRL3/WNT9B/MIOS/GRB10/TSC2	63
KEGG	hsa05220	Chronic myeloid leukemia	32/2990	76/8135	0.1962	0.7124	0.6691	AKT2/IKBKB/SMAD4/RB1/MDM2/BAD/BAK1/CHUK/STAT5A/SHC1/GRB2/POLK/GADD45A/KRAS/SOS2/TP53/ARAF/AKT1/HDAC1/BRAF/CCND1/CDKN1A/E2F2/RELA/CTBP1/CDKN2A/NRAS/PIK3R3/SOS1/MAPK1/MAPK3/GADD45G	32
KEGG	hsa05010	Alzheimer disease	149/2990	384/8135	0.2119	0.7351	0.6904	ND6/ATG101/AKT2/BECN1/APH1A/IKBKB/COX5B/TNF/SLC39A13/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/CSF1/SLC25A4/CTNNB1/BAD/PPID/ND5/DVL2/NDUFB3/NDUFB10/COX2/NDUFB6/PSMA1/KLC4/DVL3/NDUFV2/CHUK/ADAM10/RTN4/PSMA2/SLC39A1/ULK2/PLCB2/NDUFA12/NDUFA2/ND2/SLC39A7/ND4/ND1/PSMA6/NAE1/CHRM3/NDUFC2/CALML5/PSMA5/GSK3B/AMBRA1/UQCRFS1/PSMD1/COX4I1/KRAS/SLC39A6/FZD9/APC2/GNAQ/CYTB/NDUFS4/AGER/PSMB6/PPP3CB/NDUFA6/KIF5B/KLC3/ARAF/UQCRC2/PPP3R1/NDUFS1/INS/CHRNA7/SLC39A2/COX6A2/TUBA3E/CASP3/NDUFB5/AKT1/COX5A/PSMD9/BRAF/NDUFB1/WNT4/PSMA4/KLC1/FZD6/MAP3K5/FZD7/DKK2/PPP3CA/RELA/PSMC1/EIF2S1/PSMC4/NDUFB11/TUBB3/CSNK1A1L/NDUFAB1/APBB1/KIF5A/UQCRQ/TNFRSF1A/NRAS/VDAC2/LRP6/PSMB5/SLC39A8/PSMD7/PIK3R3/NDUFV1/PSENEN/NDUFA10/WNT10A/COX7B/ND3/IDE/CHRM5/TUBB2A/CSNK2B/CASP12/CALM1/CASP8/MAPK1/CACNA1F/RB1CC1/CASP7/WIPI1/MAPK10/IRS1/SNCA/ATF6/FADD/PSMB7/CYBB/NOS1/SLC39A3/ADRM1/WNT2/MTOR/APAF1/CACNA1C/MAPK3/UQCRC1/SDHC/WNT9B/TUBB/ITPR1/ATF4	149
KEGG	hsa03050	Proteasome	20/2990	46/8135	0.2119	0.7351	0.6904	POMP/PSMA1/PSMA2/PSMA6/PSMA5/PSMD1/PSMB9/PSMB6/PSMD9/PSMA4/PSME2/PSMC1/PSME3/PSMC4/PSMB10/PSME4/PSMB5/PSMD7/PSMB7/ADRM1	20
KEGG	hsa04068	FoxO signaling pathway	53/2990	131/8135	0.2125	0.7351	0.6904	PRKAB1/AKT2/IKBKB/SMAD4/MDM2/FASLG/CCNG2/CCND2/SIRT1/CHUK/IGF1/IL10/PDPK1/PRKAB2/HOMER2/GRB2/GADD45A/KRAS/SOS2/ARAF/PRKAG1/GABARAPL2/S1PR1/SGK1/INS/AKT1/BRAF/CCND1/TNFSF10/FOXO3/CDKN1A/HOMER3/CDKN2D/PCK2/GABARAP/GABARAPL1/NRAS/MAPK12/PIK3R3/KLF2/SOS1/CCNB3/MAPK1/MAPK10/IRS1/PLK1/MAPK11/PTEN/CCNB2/MAPK3/G6PC3/FOXG1/GADD45G	53
KEGG	hsa03440	Homologous recombination	18/2990	41/8135	0.2135	0.7351	0.6904	PALB2/TOP3B/RPA2/TOP3A/POLD3/BABAM1/BRIP1/RAD52/RAD51C/XRCC3/UIMC1/SYCP3/POLD2/POLD4/RAD50/RAD51B/BRCA2/EME1	18
KEGG	hsa05219	Bladder cancer	18/2990	41/8135	0.2135	0.7351	0.6904	RB1/MDM2/KRAS/THBS1/TP53/ARAF/ERBB2/BRAF/CCND1/CDKN1A/CDH1/E2F2/UPK3A/CDKN2A/NRAS/RASSF1/MAPK1/MAPK3	18
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	41/2990	100/8135	0.2162	0.7351	0.6904	TNF/TNFRSF14/CSF1/IL2RB/TNFRSF10D/ACKR3/IL6R/IL10/TNFRSF10B/TNFRSF10A/CX3CR1/CCR7/CCR3/CCR4/CSF1R/CCL17/IL10RB/CCR2/CXCL13/LTA/CXCL10/TNFSF10/TNFRSF1B/IL10RA/CCL16/CCR8/TNFRSF1A/IL22RA1/CXCR3/LTBR/CCL26/IL18R1/CXCL11/CXCR5/IL20/CCR1/IL18RAP/XCL2/CCL22/XCR1/IL2	41
KEGG	hsa04662	B cell receptor signaling pathway	34/2990	82/8135	0.2184	0.7351	0.6904	AKT2/IKBKB/VAV1/CHUK/FOS/IFITM1/NFATC1/NFKBIB/CD81/GSK3B/GRB2/KRAS/SOS2/PPP3CB/PTPN6/PPP3R1/JUN/AKT1/PPP3CA/RELA/PRKCB/PLCG2/NRAS/PIK3R3/SOS1/LILRB1/MAPK1/PIK3AP1/LILRA1/BTK/MAPK3/LYN/CR2/CARD11	34
KEGG	hsa04659	Th17 cell differentiation	44/2990	108/8135	0.2213	0.7351	0.6904	IL23A/IKBKB/SMAD4/IL21R/IL2RB/IL27RA/CHUK/STAT5A/FOS/IL4R/PLCG1/IL6R/NFATC1/NFKBIB/RARA/AHR/IL21/PPP3CB/HSP90AA1/PPP3R1/JUN/JAK3/HIF1A/IL4/HSP90AB1/STAT6/PPP3CA/FOXP3/RELA/LAT/IL22/HLA-DRA/MAPK12/RXRB/HLA-DMB/CD3D/MAPK1/MAPK10/ZAP70/MAPK11/IL17A/MTOR/MAPK3/IL2	44
KEGG	hsa05130	Pathogenic Escherichia coli infection	78/2990	197/8135	0.2223	0.7351	0.6904	IKBKB/TNF/TUBA3C/ABI1/MYH11/TIRAP/WIPF1/FASLG/TAB1/BAK1/CYTH2/CHUK/FOS/CYTH1/TNFRSF10B/ARHGEF1/BRK1/TNFRSF10A/NFKBIB/ARHGEF2/WIPF2/ARPC1B/FYN/CYTH4/CLDN15/MYH10/WASF2/TAB3/MYO1D/TRAF6/PTPN6/JUN/TUBA3E/CASP3/NCK2/ARF1/MYO1A/TNFSF10/MYH14/LPAR2/TRADD/RELA/CLDN10/TUBB3/ARPC5L/CLDN14/TNFRSF1A/ACTB/MAPK12/SEC24B/ARHGEF11/ARF6/WASL/LPAR5/HCLS1/TUBB2A/ARPC1A/SLC9A3R1/CASP8/MAPK1/CASP7/MYH9/ROCK2/WASF3/MAPK10/TMBIM6/ACTR3B/CYTH3/FADD/MAPK11/SEC24A/ARHGEF12/MAPK3/ARPC5/TUBB/MYO10/CLDN16/SEC24C	78
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	9/2990	19/8135	0.2323	0.7606	0.7144	CS/IDH3B/AADAT/GOT2/ACO1/IDH1/GOT1L1/ACY1/BCAT2	9
KEGG	hsa04917	Prolactin signaling pathway	29/2990	70/8135	0.2434	0.7819	0.7344	SOCS4/AKT2/SOCS7/CCND2/STAT5A/FOS/SHC1/CISH/GSK3B/GRB2/KRAS/SOS2/GALT/INS/AKT1/CCND1/FOXO3/RELA/ESR1/NRAS/MAPK12/LHB/PIK3R3/SOS1/MAPK1/MAPK10/MAPK11/PRLR/MAPK3	29
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	87/2990	222/8135	0.2435	0.7819	0.7344	AKT2/IKBKB/TNF/KAT5/SMAD4/RB1/SLC25A4/IL2RB/EGR1/MAP3K14/CCND2/CRTC3/CHUK/STAT5A/ADCY7/FOS/RANBP3/ATF6B/NFATC1/VAC14/MAD2L1/KRAS/ANAPC7/CHEK1/PPP3CB/TP53/MAP3K1/DLG1/NFKB2/CDC26/PPP3R1/JUN/FOSL1/JAK3/MSX1/AKT1/CDKN2C/LTA/CDC23/CCNE2/CCND1/CDKN1A/PPP3CA/E2F2/CALR/RELA/CD40/CREB3L1/CCNE1/CDKN2A/B2M/TRRAP/GPS2/TNFRSF1A/CRTC1/HLA-DRA/NRAS/VDAC2/CDC20/PIK3R3/TERT/SRF/LTBR/HLA-DMB/ADCY4/CREB1/ITGB2/EGR2/CD3D/PRKACG/MAPK1/MAPK10/HLA-C/TBPL1/KAT2B/MAD1L1/PTEN/ITGAL/IL15/CCNA1/CCNB2/MAPK3/ATF2/CREB3L4/ATR/IL2/ATF4	87
KEGG	hsa04927	Cortisol synthesis and secretion	27/2990	65/8135	0.2483	0.79	0.7419	SP1/ADCY7/ORAI1/AGTR1/PLCB2/ATF6B/PDE8B/GNAQ/PDE8A/CACNA1I/CREB3L1/ADCY4/CREB1/CACNA1G/PRKACG/CACNA1F/POMC/CACNA1C/ATF2/NR4A1/CREB3L4/AGT/SCARB1/CYP21A2/ITPR1/MC2R/ATF4	27
KEGG	hsa05203	Viral carcinogenesis	80/2990	204/8135	0.252	0.7931	0.7449	MRPS18B/GTF2A2/YWHAZ/GTF2E1/GTF2H4/RB1/MDM2/IRF7/BAD/CCND2/BAK1/STAT5A/DNAJA3/C3/ATF6B/RBPJ/DDX3X/HDAC7/VAC14/HDAC8/UBE3A/CHD4/CCR3/GRB2/CCR4/MAPKAPK2/IRF3/KRAS/TRAF1/CHEK1/TP53/DLG1/NFKB2/YWHAE/JUN/JAK3/CASP3/HDAC1/CCNE2/CCND1/CDKN1A/TRADD/HDAC11/RELA/PSMC1/ACTN1/CREB3L1/YWHAB/CCNE1/CDKN2A/CCR8/HDAC3/NRAS/HDAC10/CDC20/PIK3R3/PXN/SRF/LTBR/CREB1/TRAF5/IRF9/EGR2/PRKACG/CASP8/TRAF3/MAPK1/CDK1/HLA-C/TBPL1/KAT2B/GTF2H1/MAD1L1/CCNA1/MAPK3/ATF2/LYN/CREB3L4/YWHAQ/ATF4	80
KEGG	hsa05020	Prion disease	106/2990	273/8135	0.2541	0.7931	0.7449	ND6/COX5B/TNF/STIP1/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/SLC25A4/NCAM1/BAD/ND5/NDUFB3/CAV1/NDUFB10/EGR1/COX2/NDUFB6/PSMA1/KLC4/NDUFV2/PSMA2/NDUFA12/NDUFA2/ATF6B/ND2/ND4/ND1/PSMA6/NDUFC2/HSPA1L/PSMA5/GSK3B/FYN/UQCRFS1/PSMD1/COX4I1/CYTB/NDUFS4/PSMB6/PPP3CB/NDUFA6/KIF5B/KLC3/UQCRC2/PPP3R1/NDUFS1/COX6A2/TUBA3E/CASP3/NDUFB5/COX5A/PSMD9/NDUFB1/PSMA4/KLC1/PPP3CA/HSPA5/PSMC1/EIF2S1/CREB3L1/PSMC4/NDUFB11/TUBB3/NDUFAB1/KIF5A/UQCRQ/MAPK12/VDAC2/PSMB5/PSMD7/PIK3R3/NDUFV1/NDUFA10/COX7B/ND3/CREB1/TUBB2A/CSNK2B/PRKACG/CASP12/C8G/MAPK1/CACNA1F/MAPK10/MAPK11/PSMB7/PRNP/CYBB/NOTCH1/ADRM1/C1QC/APAF1/CACNA1C/MAPK3/ATF2/UQCRC1/SDHC/TUBB/HSPA6/CREB3L4/C1QA/ITPR1/ATF4	106
KEGG	hsa04136	Autophagy - other	14/2990	32/8135	0.2587	0.8	0.7514	ATG101/BECN1/ULK2/ATG3/ATG4C/GABARAPL2/ATG16L1/ATG4A/GABARAP/GABARAPL1/ATG4B/WIPI1/ATG9B/MTOR	14
KEGG	hsa04810	Regulation of actin cytoskeleton	85/2990	218/8135	0.2655	0.8131	0.7636	PIP4K2B/MYL12B/MYH11/MRAS/TMSB4X/VAV1/PFN3/RRAS2/FGFR2/PPP1R12C/ITGAE/ITGA10/ITGB8/FGD3/TMSB4Y/FGF3/ARHGEF1/BRK1/PPP1R12A/CHRM3/GIT1/DIAPH3/ARPC1B/MYL7/TIAM1/MYH10/KRAS/CFL1/SOS2/APC2/WASF2/ITGAV/BCAR1/ARAF/FGFR4/DOCK1/ITGA5/INS/PPP1CB/ARHGEF7/BRAF/PIP5K1B/PIP4K2C/MYL2/FGD1/MYH14/PIP5K1A/FGF6/LPAR2/PDGFC/ACTN1/FGF20/SLC9A1/RDX/ARPC5L/ACTB/NRAS/WASL/PFN4/BDKRB2/PIK3R3/LPAR5/RRAS/PXN/FN1/MSN/IQGAP2/SOS1/ITGB2/PTK2/CHRM5/ARPC1A/MAPK1/MYH9/ROCK2/PDGFB/ACTR3B/FGF23/ITGB7/ITGAL/FGF21/ARHGEF12/PIP4K2A/MAPK3/ARPC5	85
KEGG	hsa05212	Pancreatic cancer	31/2990	76/8135	0.2678	0.8131	0.7636	AKT2/IKBKB/SMAD4/RB1/BAD/BAK1/CHUK/PLD2/POLK/GADD45A/KRAS/TP53/ARAF/ERBB2/RPS6KB1/AKT1/BRAF/CCND1/CDKN1A/E2F2/RELA/RALA/RALBP1/CDKN2A/PIK3R3/MAPK1/MAPK10/BRCA2/MTOR/MAPK3/GADD45G	31
KEGG	hsa05016	Huntington disease	118/2990	306/8135	0.2706	0.8142	0.7647	ND6/ATG101/BECN1/COX5B/ACTR10/COX1/NDUFS3/COX6C/TUBA3C/COX6B1/NDUFA9/DCTN1/POLR2H/SLC25A4/ND5/NDUFB3/SP1/NDUFB10/DCTN6/COX2/NDUFB6/PSMA1/KLC4/NDUFV2/POLR2K/BBC3/PSMA2/ULK2/AP2B1/PLCB2/NDUFA12/NDUFA2/ND2/ND4/GPX6/ND1/PSMA6/NDUFC2/PSMA5/POLR2G/AMBRA1/UQCRFS1/PSMD1/COX4I1/GNAQ/CYTB/DNAH1/NDUFS4/DCTN5/PSMB6/NDUFA6/TP53/KIF5B/KLC3/UQCRC2/NDUFS1/DNAL4/AP2A2/REST/TGM2/COX6A2/TUBA3E/CASP3/NDUFB5/COX5A/PSMD9/HDAC1/NDUFB1/PSMA4/KLC1/MAP3K5/DNAH6/CLTB/HIP1/PSMC1/DNAI1/SLC1A2/CREB3L1/PSMC4/NDUFB11/TUBB3/NDUFAB1/KIF5A/UQCRQ/CLTA/VDAC2/PSMB5/PSMD7/NDUFV1/NDUFA10/COX7B/ND3/CREB1/TUBB2A/DCTN2/CASP8/POLR2B/GPX2/RB1CC1/WIPI1/MAPK10/AP2M1/TBPL1/PSMB7/DNAH12/STX1A/ADRM1/MTOR/DCTN4/GPX7/APAF1/POLR2J/UQCRC1/DNAH8/SDHC/TUBB/CREB3L4/ITPR1	118
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	22/2990	53/8135	0.2792	0.8327	0.782	KLK1/AP2B1/PLCB2/GNAQ/ATP1A4/DNM1/AP2A2/CLTB/ATP2B3/ESR1/PRKCB/ATP1B2/ATP2B2/CLTA/ATP1A1/BDKRB2/DNM2/PRKACG/VDR/AP2M1/KL/RAB11A	22
KEGG	hsa04260	Cardiac muscle contraction	35/2990	87/8135	0.2842	0.84	0.7889	COX5B/COX1/COX6C/COX6B1/CACNB1/COX2/TNNI3/MYH6/UQCRFS1/COX4I1/CYTB/TPM3/MYL4/ATP1A4/UQCRC2/COX6A2/COX5A/MYL2/TPM1/SLC9A1/ATP1B2/CACNG4/CACNG6/UQCRQ/ATP1A1/CACNB3/COX7B/CACNA2D2/CASQ2/CACNA1F/TNNT2/ASPH/CACNA1C/UQCRC1/TPM4	35
KEGG	hsa04530	Tight junction	66/2990	169/8135	0.2911	0.8443	0.793	PRKAB1/RAP1A/TUBA3C/PPP2R2D/MYL12B/MYH11/MYL6B/TJP2/LLGL1/NEDD4L/ARHGEF2/ARPC1B/PRKAB2/CGN/TIAM1/CLDN15/MYH10/CD1E/CD1D/MAP3K1/DLG1/PRKAG1/NEDD4/PPP2R2A/ERBB2/CD1A/JUN/TUBA3E/RAPGEF2/RAPGEF6/TJP3/MYL2/MAP3K5/CCND1/MYH14/ACTN1/CGNL1/CLDN10/RDX/WHAMM/ARPC5L/CLDN14/ACTB/SYMPK/RAB13/HCLS1/ARHGEF18/RAB8B/MSN/PRKACG/ARPC1A/SLC9A3R1/DLG2/MYH9/ROCK2/MAPK10/ACTR3B/YBX3/RAP2C/AMOTL1/BVES/PPP2R2C/CRB3/ARPC5/CLDN16/VASP	66
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2990	20/8135	0.2922	0.8443	0.793	B3GAT3/CHST12/CHPF2/XYLT2/B4GALT7/UST/XYLT1/CHSY3/CHSY1	9
KEGG	hsa05211	Renal cell carcinoma	28/2990	69/8135	0.2933	0.8443	0.793	AKT2/RAP1A/BAD/RBX1/PRCC/FLCN/CUL2/RAP1B/GRB2/KRAS/SOS2/ARAF/JUN/HIF1A/AKT1/HGF/BRAF/CDKN1A/FH/EGLN2/GAB1/NRAS/PIK3R3/SOS1/MAPK1/PDGFB/ARNT2/MAPK3	28
KEGG	hsa04935	Growth hormone synthesis, secretion and action	47/2990	119/8135	0.2964	0.8443	0.793	AKT2/GNAI2/STAT5A/ADCY7/FOS/IGF1/PLCG1/PLCB2/ATF6B/SHC1/GSK3B/GRB2/KRAS/SOS2/GNAQ/MAP3K1/BCAR1/SST/AKT1/JUNB/SSTR2/CREB3L1/PRKCB/PLCG2/NRAS/MAPK12/MAP2K3/PIK3R3/GHRH/ADCY4/CREB1/SOS1/PTK2/PRKACG/MAPK1/CACNA1F/MAPK10/IRS1/MAPK11/IGFBP3/MTOR/CACNA1C/MAPK3/ATF2/CREB3L4/ITPR1/ATF4	47
KEGG	hsa05100	Bacterial invasion of epithelial cells	31/2990	77/8135	0.2983	0.8443	0.793	CTNNB1/CAV1/CD2AP/SHC1/ARPC1B/WASF2/ELMO2/BCAR1/DOCK1/DNM1/ITGA5/CDH1/CLTB/GAB1/ARPC5L/ACTB/CLTA/WASL/PIK3R3/PXN/FN1/HCLS1/ELMO3/DNM2/PTK2/ARPC1A/CTNNA2/ACTR3B/CTNNA1/CTNNA3/ARPC5	31
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	86/2990	223/8135	0.3077	0.8585	0.8063	ND6/AKT2/IKBKB/COX5B/AKR1C3/COX1/NDUFS3/COX6C/COX6B1/NDUFA9/SLC25A4/BAD/ND5/NDUFB3/NDUFB10/COX2/NDUFB6/MAP3K14/NDUFV2/CBR1/CHUK/FOS/NDUFA12/NDUFA2/ND2/ND4/PDPK1/ND1/MGST3/PLD2/NDUFC2/GRB2/AHR/UQCRFS1/GSTA4/COX4I1/KRAS/SOS2/CYTB/NDUFS4/NDUFA6/ARAF/UQCRC2/SLC26A2/NDUFS1/JUN/AS3MT/COX6A2/NDUFB5/HIF1A/AKT1/COX5A/HGF/BRAF/NDUFB1/MAP3K5/FOXO3/HMOX1/AKR1A1/MGST1/GSTA2/RELA/NDUFB11/NDUFAB1/UQCRQ/NRAS/MAPK12/VDAC2/PIK3R3/NDUFV1/NDUFA10/COX7B/ND3/SOS1/PTK2/MAPK1/CYP2E1/MAPK10/GSTA5/MAPK11/PTEN/MAPK3/UQCRC1/SDHC/EPHX4/GSTM1	86
KEGG	hsa04370	VEGF signaling pathway	24/2990	59/8135	0.3084	0.8585	0.8063	AKT2/BAD/PLCG1/NOS3/MAPKAPK2/MAPKAPK3/KRAS/PPP3CB/PPP3R1/AKT1/PLA2G4C/PLA2G4D/PPP3CA/PRKCB/PLCG2/NRAS/MAPK12/SH2D2A/PIK3R3/PXN/PTK2/MAPK1/MAPK11/MAPK3	24
KEGG	hsa04630	JAK-STAT signaling pathway	63/2990	162/8135	0.3114	0.8595	0.8072	SOCS4/AKT2/IL23A/SOCS7/IL21R/IL2RB/IL27RA/PIAS3/STAT2/CCND2/STAT5A/IL4R/IL6R/IL10/IFNA21/CISH/PTPN2/GFAP/GRB2/LEP/IL11RA/IL21/SOS2/PTPN6/IL7/JAK3/IL10RB/IL4/AKT1/IL5RA/IFNA2/CCND1/STAT6/CDKN1A/IFNA5/IL10RA/EPOR/CRLF2/CSF2RB/IL22/IL22RA1/BCL2/IL17D/PIK3R3/IL12RB2/SOS1/IRF9/MCL1/IL13RA2/IFNA17/CTF1/PDGFB/LIF/PIAS2/IL3RA/IL20/IL15/MTOR/PRLR/STAM/OSM/FHL1/IL2	63
KEGG	hsa04216	Ferroptosis	17/2990	41/8135	0.3174	0.8689	0.816	PCBP2/TFRC/TP53/LPCAT3/GCLM/HMOX1/MAP1LC3B2/TF/NCOA4/VDAC2/SLC39A8/MAP1LC3C/GPX4/GSS/PRNP/CYBB/ACSL3	17
KEGG	hsa00511	Other glycan degradation	8/2990	18/8135	0.3268	0.8816	0.8279	MAN2B2/MAN2C1/GBA2/NEU1/NEU4/ENGASE/NEU2/NEU3	8
KEGG	hsa05224	Breast cancer	57/2990	147/8135	0.3328	0.8816	0.8279	AKT2/RB1/CTNNB1/DVL2/SP1/BAK1/DVL3/FOS/IGF1/SHC1/FGF3/GSK3B/GRB2/POLK/GADD45A/KRAS/SOS2/FZD9/APC2/HES1/TP53/ARAF/NFKB2/ERBB2/JUN/RPS6KB1/TCF7L2/AKT1/BRAF/WNT4/FZD6/FZD7/CCND1/CDKN1A/FGF6/E2F2/FGF20/ESR1/CSNK1A1L/NRAS/TCF7/LRP6/PIK3R3/WNT10A/SOS1/NOTCH2/MAPK1/FGF23/NOTCH1/BRCA2/PTEN/FGF21/WNT2/MTOR/MAPK3/WNT9B/GADD45G	57
KEGG	hsa05415	Diabetic cardiomyopathy	78/2990	203/8135	0.3334	0.8816	0.8279	ND6/AKT2/COX5B/COX1/NDUFS3/COX6C/COX6B1/NDUFA9/SLC25A4/ND5/NDUFB3/SP1/NDUFB10/COX2/NDUFB6/NDUFV2/PLN/AGTR1/PLCB2/NDUFA12/NDUFA2/ND2/ND4/ND1/TNNI3/NDUFC2/GFPT1/GSK3B/NOS3/UQCRFS1/PDHA2/COX4I1/PDK4/CYTB/NDUFS4/AGER/MPC1L/NDUFA6/UQCRC2/NDUFS1/INS/PPP1CB/COX6A2/NDUFB5/AKT1/COX5A/NDUFB1/PDHB/RELA/PRKCB/NDUFB11/NDUFAB1/UQCRQ/MAPK12/CAMK2A/VDAC2/CPT2/PIK3R3/NDUFV1/COL1A2/MPC2/NDUFA10/PDHA1/COX7B/ND3/CAMK2D/MAPK10/IRS1/MAPK11/CYBB/PTEN/COL1A1/MTOR/UQCRC1/SDHC/AGT/MPC1/GSR	78
KEGG	hsa04657	IL-17 signaling pathway	37/2990	94/8135	0.3347	0.8816	0.8279	IKBKB/TNF/IKBKE/CHUK/FOS/GSK3B/FOSB/TAB3/TRAF6/IL17B/HSP90AA1/JUN/FOSL1/CCL17/CASP3/IL4/ELAVL1/CXCL10/HSP90AB1/TRADD/RELA/SRSF1/MAPK12/IL17D/LCN2/HSP90B1/USP25/TRAF5/CASP8/TRAF3/MAPK1/MAPK10/FADD/MAPK11/IL17A/TNFAIP3/MAPK3	37
KEGG	hsa04710	Circadian rhythm	13/2990	31/8135	0.3352	0.8816	0.8279	PRKAB1/RBX1/CSNK1D/PRKAB2/BTRC/BHLHE41/PRKAG1/FBXL3/FBXW11/SKP1/CREB1/PER2/RORB	13
KEGG	hsa00190	Oxidative phosphorylation	52/2990	134/8135	0.34	0.8871	0.8332	ND6/COX15/COX5B/COX1/NDUFS3/COX6C/COX6B1/NDUFA9/TCIRG1/ND5/NDUFB3/NDUFB10/COX2/NDUFB6/COX17/NDUFV2/NDUFA12/NDUFA2/ND2/ND4/ATP6V1C2/ND1/NDUFC2/UQCRFS1/COX4I1/CYTB/NDUFS4/NDUFA6/UQCRC2/ATP6V1B1/NDUFS1/COX6A2/NDUFB5/COX5A/NDUFB1/ATP6V0E2/NDUFB11/ATP6V1G3/ATP4B/NDUFAB1/COX10/ATP6AP1/UQCRQ/ATP6V0B/NDUFV1/NDUFA10/COX7B/ND3/ATP6V1A/PPA2/UQCRC1/SDHC	52
KEGG	hsa00620	Pyruvate metabolism	19/2990	47/8135	0.351	0.9067	0.8516	LDHB/ACSS1/ACYP2/DLAT/ME3/PDHA2/PDHB/AKR1A1/ACSS2/FH/HAGH/PCK2/ADH1A/GRHPR/PDHA1/DLD/ACAT1/PC/ADH4	19
KEGG	hsa05170	Human immunodeficiency virus 1 infection	81/2990	212/8135	0.3529	0.9067	0.8516	AKT2/IKBKB/TNF/GNAI2/BAD/FASLG/TAB1/BAK1/CHUK/FOS/PLCG1/IFNA21/RBX1/NFATC1/CALML5/IRF3/KRAS/CFL1/GNAQ/WEE1/CHEK1/PPP3CB/BTRC/GNG7/GNG5/TRAF6/CUL5/PPP3R1/JUN/FBXW11/RPS6KB1/CASP3/AKT1/IFNA2/GNB1/SKP1/AP1S1/IFNA5/TNFRSF1B/TRADD/PPP3CA/CALR/RELA/TAP1/PRKCB/PLCG2/B2M/APOBEC3F/TNFRSF1A/NRAS/MAPK12/BCL2/GNG11/MAP2K3/PIK3R3/PXN/TRAF5/PTK2/CD3D/CALM1/APOBEC3D/CASP8/CCNB3/TAP2/IFNA17/MAPK1/CDK1/MAPK10/APOBEC3B/HLA-C/FADD/MAPK11/APOBEC3H/AP1S2/GNGT1/CCNB2/MTOR/AP1G2/MAPK3/ATR/ITPR1	81
KEGG	hsa04072	Phospholipase D signaling pathway	57/2990	148/8135	0.3564	0.9072	0.8521	AKT2/MRAS/DGKZ/CYTH2/ADCY7/AGTR1/RRAS2/TSC1/PLCG1/PLCB2/CYTH1/SHC1/MS4A2/AGPAT5/PLD2/DGKK/FYN/GRB2/CYTH4/KRAS/SOS2/PIK3R6/DNM1/INS/AKT1/ARF1/PIP5K1B/DGKA/PLA2G4C/PLA2G4D/PIP5K1A/LPAR2/PDGFC/RALA/DGKH/PIK3R5/GAB1/PLCG2/NRAS/FCER1A/ARF6/PIK3R3/LPAR5/RRAS/GRM6/ADCY4/SOS1/DNM2/MAPK1/PDGFB/CYTH3/MTOR/AVP/MAPK3/AGT/GRM4/TSC2	57
KEGG	hsa05217	Basal cell carcinoma	25/2990	63/8135	0.3586	0.9072	0.8521	SUFU/CTNNB1/DVL2/BAK1/DVL3/KIF7/GSK3B/POLK/GADD45A/FZD9/APC2/TP53/TCF7L2/WNT4/FZD6/FZD7/CDKN1A/GLI2/TCF7/WNT10A/BMP2/PTCH2/WNT2/WNT9B/GADD45G	25
KEGG	hsa04974	Protein digestion and absorption	40/2990	103/8135	0.3649	0.9111	0.8557	CTRL/COL5A3/COL5A1/COL4A4/COL4A3/COL27A1/KCNJ13/COL22A1/COL8A2/PGA3/COL9A3/CTRB2/COL26A1/COL23A1/ATP1A4/KCNN4/COL9A2/COL13A1/COL6A1/COL6A2/ATP1B2/COL4A1/SLC1A5/ATP1A1/COL18A1/COL1A2/COL2A1/COL20A1/COL9A1/COL4A5/PRSS1/COL7A1/COL16A1/CPA1/COL1A1/COL12A1/SLC6A19/KCNE3/COL11A1/COL28A1	40
KEGG	hsa00591	Linoleic acid metabolism	12/2990	29/8135	0.3673	0.9111	0.8557	PLA2G6/PLA2G1B/CYP2C9/PLA2G4C/PLA2G4D/CYP2C19/PLA2G10/PLA2G2A/CYP2C8/CYP2E1/CYP3A4/PLA2G3	12
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	15/2990	37/8135	0.3742	0.9111	0.8557	IGF1/PDPK1/NEDD4L/KRAS/ATP1A4/SGK1/INS/PRKCB/ATP1B2/ATP1A1/PIK3R3/NR3C2/MAPK1/IRS1/MAPK3	15
KEGG	hsa04014	Ras signaling pathway	88/2990	232/8135	0.3771	0.9111	0.8557	AKT2/RAP1A/IKBKB/CSF1/BAD/MRAS/EPHA2/FASLG/CHUK/PLA2G6/IGF1/RRAS2/FGFR2/PLCG1/RASAL3/SHC1/FGF3/PLD2/PLA2G1B/CALML5/FLT3LG/RAP1B/SHOC2/GRB2/TIAM1/KRAS/KSR1/EFNA3/SOS2/SYNGAP1/GNG7/GNG5/FGFR4/RASSF5/CSF1R/INS/AKT1/HGF/VEGFC/RAB5C/PLA2G4C/PLA2G4D/GNB1/FGF6/PDGFC/RELA/RALA/RASA4/RGL1/FGF20/NGF/PRKCB/GAB1/RALBP1/LAT/PLCG2/FLT3/NRAS/EFNA2/RASGRF2/GNG11/KSR2/ARF6/PIK3R3/RRAS/RASSF1/SOS1/PLCE1/PRKACG/CALM1/PLA2G10/PLA2G2A/MAPK1/RGL2/PDGFB/MAPK10/ZAP70/BRAP/PGF/FGF23/NTRK2/GNGT1/FGF21/NGFR/MAPK3/ANGPT2/PLA2G3/RAB5A	88
KEGG	hsa02010	ABC transporters	18/2990	45/8135	0.3784	0.9111	0.8557	ABCC2/ABCB10/ABCB8/ABCC10/ABCD4/ABCA9/ABCC5/TAP1/ABCA7/ABCB1/DEFB1/ABCC4/ABCG2/ABCB5/TAP2/ABCD1/ABCA1/ABCG1	18
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/2990	24/8135	0.3805	0.9111	0.8557	B3GAT3/EXT2/HS6ST3/GLCE/XYLT2/B4GALT7/EXTL3/NDST4/XYLT1/EXTL1	10
KEGG	hsa04977	Vitamin digestion and absorption	10/2990	24/8135	0.3805	0.9111	0.8557	MMACHC/SLC46A1/SLC5A6/APOA1/LMBRD1/SLC23A1/RBP2/BTD/PNLIP/SCARB1	10
KEGG	hsa04920	Adipocytokine signaling pathway	27/2990	69/8135	0.3838	0.9111	0.8557	PRKAB1/AKT2/IKBKB/TNF/CHUK/NFKBIB/PRKAB2/LEP/PRKAG1/ADIPOR1/AKT1/TNFRSF1B/TRADD/RELA/PCK2/CPT1C/CPT1A/TNFRSF1A/RXRB/ADIPOR2/ACSBG1/MAPK10/IRS1/POMC/ACSL3/MTOR/G6PC3	27
KEGG	hsa04012	ErbB signaling pathway	33/2990	85/8135	0.3846	0.9111	0.8557	AKT2/BAD/EIF4EBP1/STAT5A/PLCG1/SHC1/GSK3B/GRB2/KRAS/SOS2/ARAF/ERBB2/JUN/RPS6KB1/AKT1/NCK2/BRAF/CDKN1A/AREG/PRKCB/GAB1/PLCG2/NRAS/CAMK2A/PIK3R3/SOS1/PTK2/NRG2/MAPK1/CAMK2D/MAPK10/MTOR/MAPK3	33
KEGG	hsa00260	Glycine, serine and threonine metabolism	16/2990	40/8135	0.3915	0.9153	0.8597	PGAM4/PGAM2/GLDC/PHGDH/SHMT1/GLYCTK/SARDH/MAOA/CBS/AOC2/GRHPR/DLD/ALAS1/CTH/CHDH/AGXT	16
KEGG	hsa04152	AMPK signaling pathway	46/2990	120/8135	0.3923	0.9153	0.8597	PRKAB1/AKT2/PPP2R2D/HMGCR/EIF4EBP1/RAB11B/SIRT1/IGF1/TSC1/MLYCD/STRADA/PDPK1/PRKAB2/LEP/PPP2R5D/EEF2/PRKAG1/ADIPOR1/SREBF1/PPP2R2A/INS/RPS6KB1/PPP2R3B/AKT1/PPP2R5A/ELAVL1/CCND1/PPP2R5E/FOXO3/STRADB/RAB2A/PCK2/CREB3L1/CPT1C/CPT1A/PIK3R3/CREB1/ADIPOR2/IRS1/FBP1/PPP2R2C/CCNA1/MTOR/CREB3L4/G6PC3/TSC2	46
KEGG	hsa05418	Fluid shear stress and atherosclerosis	53/2990	139/8135	0.3985	0.9153	0.8597	AKT2/IKBKB/TNF/SUMO1/CTNNB1/SUMO2/CAV1/ACVR2B/CHUK/FOS/MGST3/ARHGEF2/CALML5/SUMO4/NOS3/GSTA4/ITGAV/TP53/HSP90AA1/JUN/AKT1/BMPR2/PECAM1/TXN2/MAP3K5/SDC1/HSP90AB1/MAP2K5/HMOX1/MGST1/GSTA2/RELA/DUSP1/TNFRSF1A/ACTB/MAPK12/BCL2/TXN/PIK3R3/CTSL/KLF2/HSP90B1/GPC1/MIR10A/TRPV4/PTK2/CALM1/SUMO3/PDGFB/MAPK10/GSTA5/MAPK11/GSTM1	53
KEGG	hsa04114	Oocyte meiosis	50/2990	131/8135	0.3997	0.9153	0.8597	SMC1A/SPDYE1/YWHAZ/ADCY7/IGF1/RBX1/CALML5/MAD2L1/ANAPC7/PPP3CB/BTRC/PPP2R5D/SMC3/YWHAE/CDC26/PPP3R1/INS/FBXW11/PPP1CB/BUB1/FBXO43/PPP2R5A/FBXO5/CDC23/CCNE2/PPP2R5E/SKP1/PPP3CA/YWHAB/CCNE1/SPDYE2/MAPK12/CAMK2A/CDC20/ADCY4/SPDYE5/REC8/PRKACG/CALM1/MAPK1/CAMK2D/CDK1/PLK1/RPS6KA3/MAPK11/MAD1L1/CCNB2/MAPK3/YWHAQ/ITPR1	50
KEGG	hsa04510	Focal adhesion	76/2990	201/8135	0.4028	0.9153	0.8597	AKT2/RAP1A/MYL12B/CHAD/CTNNB1/BAD/CAV1/CCND2/VAV1/COL4A4/IGF1/PPP1R12C/ITGA10/ITGB8/SHC1/COL4A3/PDPK1/PPP1R12A/RAP1B/GSK3B/COL9A3/MYL7/FYN/GRB2/SOS2/ITGAV/THBS1/BCAR1/COL9A2/DOCK1/ERBB2/ITGA5/JUN/ZYX/PPP1CB/AKT1/HGF/BRAF/PIP5K1B/LAMB1/VEGFC/COL6A1/MYL2/CCND1/PIP5K1A/PDGFC/ACTN1/BIRC2/COL6A2/PRKCB/COL4A1/ACTB/BCL2/PIK3R3/COL1A2/PXN/FN1/IBSP/COL2A1/SOS1/PTK2/COL9A1/COL4A5/MAPK1/ROCK2/PDGFB/MAPK10/PGF/ARHGAP5/PTEN/ITGB7/LAMA3/COL1A1/PARVA/MAPK3/VASP	76
KEGG	hsa03320	PPAR signaling pathway	29/2990	75/8135	0.4073	0.9153	0.8597	PLIN2/APOA2/SCP2/ACOX3/PDPK1/ME3/ANGPTL4/EHHADH/APOA1/PPARD/SLC27A1/HMGCS1/CYP8B1/PCK2/FABP7/CPT1C/CPT1A/ACAA1/FABP5/RXRB/CPT2/APOC3/FABP3/ACSBG1/UBC/FABP1/ACSL3/DBI/SLC27A5	29
KEGG	hsa00010	Glycolysis / Gluconeogenesis	26/2990	67/8135	0.408	0.9153	0.8597	PGAM4/LDHB/PGAM2/ACSS1/DLAT/ALDOC/PDHA2/GAPDHS/PDHB/AKR1A1/ENO1/ACSS2/PCK2/ADH1A/PGM1/PDHA1/PGM2/DLD/GPI/ADPGK/HK1/ALDOB/GALM/FBP1/G6PC3/ADH4	26
KEGG	hsa00270	Cysteine and methionine metabolism	20/2990	51/8135	0.4083	0.9153	0.8597	ENOPH1/MRI1/BHMT2/LDHB/MTAP/MTR/LACC1/AHCYL1/GOT2/IL4I1/PHGDH/GCLM/SMS/CBS/GOT1L1/DNMT3B/MAT2B/GSS/CTH/BCAT2	20
KEGG	hsa04612	Antigen processing and presentation	30/2990	78/8135	0.4185	0.9284	0.8719	TNF/NFYC/HSPA1L/RFX5/HSP90AA1/KIR2DS4/KLRD1/HSP90AB1/HSPA5/PSME2/KIR2DS1/CALR/NFYA/TAP1/PSME3/KIR2DS2/B2M/HLA-DRA/CTSL/KIR3DL2/HLA-DMB/CREB1/CD8B/KIR3DL3/TAP2/HLA-C/CIITA/IFI30/KIR2DL1/HSPA6	30
KEGG	hsa04725	Cholinergic synapse	43/2990	113/8135	0.4215	0.9284	0.8719	AKT2/GNAI2/ADCY7/FOS/PLCB2/CHRM3/FYN/KRAS/GNAQ/GNG7/GNG5/PIK3R6/KCNJ12/KCNQ3/CHRNA7/AKT1/KCNJ2/GNB1/ACHE/CREB3L1/PRKCB/PIK3R5/NRAS/BCL2/CAMK2A/GNG11/PIK3R3/CHRNB4/ADCY4/CREB1/CHRM5/PRKACG/MAPK1/CAMK2D/CACNA1F/CHRNB2/CHRNA3/GNGT1/CACNA1C/MAPK3/CREB3L4/ITPR1/ATF4	43
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	12/2990	30/8135	0.4225	0.9284	0.8719	HYI/ACSS1/CS/GLDC/ACO1/SHMT1/ACSS2/GLYCTK/GRHPR/DLD/ACAT1/AGXT	12
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	34/2990	89/8135	0.4272	0.9327	0.8759	AKT2/IKBKB/TIRAP/CHUK/FOS/PLCG1/NFATC1/NFKBIB/TICAM1/KRAS/PPP3CB/TRAF6/PTPN6/PPP3R1/JUN/RPS6KB1/HIF1A/AKT1/CD28/PPP3CA/RELA/LAT/NRAS/MAPK12/MAP2K3/PIK3R3/CD3D/CSNK2B/MAPK1/ZAP70/MAPK11/PTEN/MTOR/MAPK3	34
KEGG	hsa05134	Legionellosis	22/2990	57/8135	0.4352	0.9439	0.8865	TNF/SAR1B/CLK4/EEF1A2/EEF1A1/C3/SAR1A/EEF1G/HSPA1L/HBS1L/NFKB2/HSPD1/CASP3/ARF1/RELA/RAB1B/ITGB2/CASP8/CASP7/CR1L/APAF1/HSPA6	22
KEGG	hsa03410	Base excision repair	13/2990	33/8135	0.4405	0.9493	0.8915	OGG1/POLE4/APEX2/HMGB1/MPG/POLD3/POLE2/NEIL1/PARP4/POLD2/TDG/NEIL3/POLD4	13
KEGG	hsa04925	Aldosterone synthesis and secretion	37/2990	98/8135	0.4561	0.9766	0.9172	ADCY7/ORAI1/AGTR1/PLCB2/ATF6B/CALML5/DAGLB/GNAQ/ATP1A4/CACNA1I/ATP2B3/CREB3L1/PRKCB/ATP1B2/ATP2B2/CAMK2A/ATP1A1/ADCY4/CREB1/CACNA1G/PRKACG/CALM1/CAMK2D/CACNA1F/CAMK1/POMC/CYP11B2/CACNA1C/ATF2/NR4A1/CREB3L4/AGT/SCARB1/CYP21A2/ITPR1/MC2R/ATF4	37
KEGG	hsa04623	Cytosolic DNA-sensing pathway	24/2990	63/8135	0.4595	0.9776	0.9181	RIPK3/IKBKB/POLR2H/IRF7/IKBKE/MAVS/CHUK/POLR2K/IFNA21/POLR1D/NFKBIB/POLR1C/POLR3A/POLR3K/IRF3/ZBP1/CXCL10/IFNA2/IFNA5/DDX58/RELA/POLR3GL/POLR3H/IFNA17	24
KEGG	hsa04912	GnRH signaling pathway	35/2990	93/8135	0.4689	0.9912	0.9309	MAP3K2/EGR1/ADCY7/PLCB2/PLD2/CALML5/GRB2/KRAS/SOS2/GNAQ/MAP3K1/JUN/PLA2G4C/PLA2G4D/PRKCB/NRAS/MAPK12/LHB/CAMK2A/MAP2K3/ADCY4/SOS1/PRKACG/CALM1/MAPK1/CAMK2D/CACNA1F/MAPK10/MMP14/FSHB/MAPK11/CACNA1C/MAPK3/ITPR1/ATF4	35
KEGG	hsa05031	Amphetamine addiction	26/2990	69/8135	0.4817	1	0.9392	SIRT1/FOS/ATF6B/CALML5/FOSB/PPP3CB/PPP3R1/JUN/PPP1CB/HDAC1/PPP3CA/CREB3L1/PRKCB/MAOA/CAMK2A/CREB1/SLC18A1/PRKACG/CALM1/PPP1R1B/CAMK2D/STX1A/CACNA1C/ATF2/CREB3L4/ATF4	26
KEGG	hsa04926	Relaxin signaling pathway	48/2990	129/8135	0.4905	1	0.9392	AKT2/GNAI2/INSL3/COL4A4/RLN2/ADCY7/FOS/PLCB2/ATF6B/SHC1/COL4A3/NOS3/GRB2/KRAS/SOS2/GNG7/GNG5/JUN/AKT1/ARRB1/VEGFC/GNB1/RELA/CREB3L1/COL4A1/NRAS/MAPK12/GNG11/PIK3R3/COL1A2/ADCY4/CREB1/SOS1/ARRB2/RXFP1/PRKACG/COL4A5/MAPK1/MAPK10/MAPK11/NOS1/GNA15/COL1A1/GNGT1/MAPK3/ATF2/CREB3L4/ATF4	48
KEGG	hsa00730	Thiamine metabolism	6/2990	15/8135	0.4931	1	0.9392	AK5/NFS1/NTPCR/AK4/AK2/THTPA	6
KEGG	hsa04350	TGF-beta signaling pathway	35/2990	94/8135	0.5005	1	0.9392	TNF/SMAD4/TFDP1/SP1/ACVR2B/RGMB/ID2/RBX1/ID3/TGIF2/ACVR1C/THBS1/SMAD6/RPS6KB1/BMPR2/ACVR1B/NOG/SKP1/SMAD7/SMURF2/DCN/GDF6/INHBE/BMP2/MAPK1/INHBB/NEO1/GDF7/BMP5/FMOD/BMP7/MAPK3/NBL1/AMHR2/INHBA	35
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	53/2990	143/8135	0.5012	1	0.9392	PCGF1/AKT2/SETDB1/SMAD4/CTNNB1/DVL2/DVL3/ACVR2B/IGF1/KLF4/FGFR2/ID2/ID3/GSK3B/ONECUT1/GRB2/KRAS/FZD9/APC2/ACVR1C/FGFR4/PCGF5/ISL1/REST/JAK3/POU5F1/AKT1/BMPR2/WNT4/ACVR1B/FZD6/FZD7/PCGF2/NRAS/MAPK12/TCF7/PCGF3/PIK3R3/WNT10A/PCGF6/INHBE/KAT6A/HOXA1/POU5F1B/MAPK1/LIF/INHBB/MAPK11/MYF5/WNT2/MAPK3/WNT9B/INHBA	53
KEGG	hsa04330	Notch signaling pathway	22/2990	59/8135	0.5153	1	0.9392	APH1A/NUMBL/LFNG/DVL2/DTX3/DVL3/RBPJ/MFNG/DTX4/HES1/NUMB/HDAC1/CTBP1/PSENEN/CIR1/NOTCH2/NCOR2/KAT2B/NOTCH1/DTX3L/MAML3/TLE2	22
KEGG	hsa05230	Central carbon metabolism in cancer	26/2990	70/8135	0.5183	1	0.9392	AKT2/PGAM4/LDHB/PGAM2/FGFR2/PDHA2/KRAS/TP53/ERBB2/SLC7A5/HIF1A/AKT1/PDHB/FLT3/IDH1/NRAS/SLC1A5/PIK3R3/PDHA1/SIRT6/HK1/MAPK1/GLS2/PTEN/MTOR/MAPK3	26
KEGG	hsa05164	Influenza A	63/2990	171/8135	0.5197	1	0.9392	RNASEL/AKT2/IKBKB/TNF/NXF1/SLC25A4/OAS2/IRF7/IKBKE/FASLG/MX1/RAB11B/STAT2/BAK1/OAS3/MAVS/CHUK/PABPN1/OAS1/RSAD2/IFNA21/TNFRSF10B/TNFRSF10A/KPNA1/NFKBIB/PML/RAE1/TICAM1/IRF3/MX2/IFIH1/CASP3/AKT1/HNRNPUL1/CXCL10/IFNA2/TNFSF10/IFNA5/DDX58/TRADD/RELA/EIF2S1/PRKCB/TNFRSF1A/ACTB/HLA-DRA/PIK3R3/KPNA7/HLA-DMB/IRF9/PRSS1/CASP8/TRAF3/IFNA17/MAPK1/CIITA/FADD/NXT1/NUP98/APAF1/MAPK3/RAB11A/TRIM25	63
KEGG	hsa04213	Longevity regulating pathway - multiple species	23/2990	62/8135	0.5257	1	0.9392	PRKAB1/AKT2/SIRT1/ADCY7/IGF1/HSPA1L/PRKAB2/KRAS/PRKAG1/INS/RPS6KB1/AKT1/HDAC1/FOXO3/NRAS/PIK3R3/ADCY4/PRKACG/IRS1/CLPB/MTOR/CRYAB/HSPA6	23
KEGG	hsa00770	Pantothenate and CoA biosynthesis	8/2990	21/8135	0.5312	1	0.9392	CSAD/ENPP3/PANK2/PPCS/ENPP1/AASDHPPT/BCAT2/PANK1	8
KEGG	hsa00640	Propanoate metabolism	12/2990	32/8135	0.5317	1	0.9392	LDHB/SUCLG1/ACSS1/ACOX3/MLYCD/DBT/EHHADH/ACSS2/HADHA/DLD/ECHS1/ECHDC1	12
KEGG	hsa00071	Fatty acid degradation	16/2990	43/8135	0.5329	1	0.9392	ACOX3/EHHADH/ACADVL/CPT1C/CPT1A/ACAA1/ADH1A/CPT2/HADHA/ECI2/CYP2U1/ECHS1/ACSBG1/ACAT1/ACSL3/ADH4	16
KEGG	hsa05133	Pertussis	28/2990	76/8135	0.5371	1	0.9392	IL23A/TNF/GNAI2/TIRAP/C3/FOS/IL10/CALML5/TICAM1/IRF3/CFL1/TRAF6/ITGA5/JUN/CASP3/RELA/MAPK12/ITGB2/CALM1/NOD1/MAPK1/CASP7/MAPK10/MAPK11/LY96/C1QC/MAPK3/C1QA	28
KEGG	hsa04066	HIF-1 signaling pathway	40/2990	109/8135	0.5414	1	0.9392	AKT2/EIF4E2/LDHB/EIF4EBP1/TFRC/IGF1/PLCG1/IL6R/RBX1/CUL2/NOS3/ALDOC/PDHA2/ERBB2/INS/RPS6KB1/HIF1A/AKT1/PDHB/HMOX1/CDKN1A/ENO1/TF/RELA/EGLN2/PRKCB/PLCG2/BCL2/CAMK2A/PIK3R3/PDHA1/LTBR/HK1/ALDOB/MAPK1/CAMK2D/CYBB/MTOR/MAPK3/ANGPT2	40
KEGG	hsa05340	Primary immunodeficiency	14/2990	38/8135	0.5566	1	0.9392	IGLL1/ORAI1/DCLRE1C/RFX5/JAK3/TAP1/CD40/CD8B/ADA/CD3D/TAP2/ZAP70/CIITA/BTK	14
KEGG	hsa04931	Insulin resistance	39/2990	108/8135	0.5916	1	0.9392	PRKAB1/AKT2/IKBKB/TNF/SLC27A3/PDPK1/GFPT1/GSK3B/PRKAB2/NOS3/PRKAG1/SREBF1/INS/RPS6KB1/PPP1CB/AKT1/SLC27A1/PYGM/PPP1R3D/RELA/PCK2/CREB3L1/PRKCB/CPT1A/PTPRF/TNFRSF1A/PIK3R3/CREB1/MLXIPL/MAPK10/IRS1/RPS6KA3/PTEN/MTOR/CREB3L4/AGT/G6PC3/NR1H2/SLC27A5	39
KEGG	hsa00500	Starch and sucrose metabolism	13/2990	36/8135	0.5942	1	0.9392	UGP2/ENPP3/AMY2B/AMY2A/GBA3/PYGM/PGM1/PGM2/AGL/GPI/HK1/ENPP1/G6PC3	13
KEGG	hsa00510	N-Glycan biosynthesis	18/2990	50/8135	0.597	1	0.9392	ALG11/DPM1/ALG3/ALG12/STT3A/GANAB/DPAGT1/DOLPP1/ALG1/TUSC3/MOGS/MAN1C1/SRD5A3/MGAT3/MAN1A1/MAN2A2/DOLK/ALG10B	18
KEGG	hsa04929	GnRH secretion	23/2990	64/8135	0.6008	1	0.9392	AKT2/KISS1/PLCB2/KRAS/GNAQ/KCNN4/GABBR1/AKT1/ARRB1/CACNA1I/PRKCB/GPER1/NRAS/LHB/PIK3R3/HCN1/ARRB2/CACNA1G/MAPK1/CACNA1F/CACNA1C/MAPK3/ITPR1	23
KEGG	hsa00592	alpha-Linolenic acid metabolism	9/2990	25/8135	0.6057	1	0.9392	PLA2G6/ACOX3/PLA2G1B/PLA2G4C/PLA2G4D/ACAA1/PLA2G10/PLA2G2A/PLA2G3	9
KEGG	hsa04720	Long-term potentiation	24/2990	67/8135	0.6087	1	0.9392	RAP1A/PLCB2/CALML5/RAP1B/KRAS/GNAQ/PPP3CB/ARAF/PPP3R1/PPP1CB/BRAF/PPP3CA/PRKCB/NRAS/CAMK2A/PRKACG/CALM1/MAPK1/CAMK2D/RPS6KA3/CACNA1C/MAPK3/ITPR1/ATF4	24
KEGG	hsa04658	Th1 and Th2 cell differentiation	33/2990	92/8135	0.6091	1	0.9392	IKBKB/IL2RB/CHUK/STAT5A/FOS/IL4R/PLCG1/RBPJ/NFATC1/NFKBIB/PPP3CB/PPP3R1/JUN/JAK3/IL4/STAT6/PPP3CA/RELA/LAT/HLA-DRA/MAPK12/HLA-DMB/IL12RB2/CD3D/NOTCH2/MAPK1/MAPK10/ZAP70/MAPK11/NOTCH1/MAML3/MAPK3/IL2	33
KEGG	hsa04310	Wnt signaling pathway	60/2990	167/8135	0.6174	1	0.9392	RYK/SMAD4/CTNNB1/DVL2/CCND2/CBY1/DVL3/PRICKLE1/PLCB2/RBX1/NFATC1/GSK3B/PORCN/FZD9/APC2/SIAH1/PPP3CB/BTRC/VANGL2/TP53/RUVBL1/PPP3R1/PRICKLE3/JUN/FBXW11/FOSL1/TCF7L2/WNT4/FZD6/FZD7/PPARD/CCND1/SKP1/LGR6/DKK2/PPP3CA/NKD2/PRKCB/CTBP1/CSNK1A1L/CAMK2A/TCF7/LRP6/DAAM2/NOTUM/WNT10A/SFRP2/CSNK2B/PRKACG/CHD8/CAMK2D/ROCK2/MAPK10/SOX17/PRICKLE4/SFRP5/WNT2/TLE2/WNT9B/SFRP1	60
KEGG	hsa05131	Shigellosis	89/2990	247/8135	0.6183	1	0.9392	AKT2/BECN1/IKBKB/TNF/CAPNS1/RNF31/MYL12B/MDM2/PPID/RRAGB/RBCK1/TAB1/CYTH2/CHUK/PFN3/C3/PLCG1/PLCB2/CYTH1/RBX1/PLCD4/NFKBIB/ARHGEF2/ARPC1B/GSK3B/MYL7/CYTH4/IRF3/WASF2/TAB3/BTRC/TP53/ELMO2/BCAR1/TRAF6/DOCK1/UBE2NL/UBA52/ITGA5/JUN/FBXW11/RPS6KB1/AKT1/ARF1/MYL2/FOXO3/SKP1/UBE2D4/MAP1LC3B2/TRADD/ATG16L1/RELA/ACTN1/PLCG2/ARPC5L/TNFRSF1A/ACTB/MAPK12/BCL2/ARF6/WASL/PFN4/PIK3R3/UBB/PXN/MAP1LC3C/HCLS1/TRAF5/PLCE1/PTK2/HK1/ARPC1A/UBE2D3/NOD1/MAPK1/ROCK2/WIPI1/MAPK10/ACTR3B/CYTH3/UBC/MAPK11/PLCD3/RRAGD/MTOR/MAPK3/ARPC5/PLCD1/ITPR1	89
KEGG	hsa03022	Basal transcription factors	16/2990	45/8135	0.6215	1	0.9392	GTF2A2/GTF2E1/TAF6L/GTF2H4/GTF2F2/TAF8/TAF6/ERCC2/TAF3/TAF1/ERCC3/GTF2H5/TBPL1/CDK7/GTF2H1/TAF12	16
KEGG	hsa00564	Glycerophospholipid metabolism	35/2990	98/8135	0.6224	1	0.9392	LYPLA2/LCAT/PCYT1A/DGKZ/PLA2G15/PLA2G6/GPAM/AGPAT5/CEPT1/PLD2/GPCPD1/DGKK/PLA2G1B/PNPLA6/LPIN3/LPCAT4/LPCAT3/PISD/DGKA/PLA2G4C/PLA2G4D/ACHE/PLD4/DGKH/MBOAT1/LYPLA1/CHKA/MBOAT2/CRLS1/LPIN1/CDS1/PTDSS1/PLA2G10/PLA2G2A/PLA2G3	35
KEGG	hsa04910	Insulin signaling pathway	49/2990	137/8135	0.6272	1	0.9392	PRKAB1/SOCS4/AKT2/IKBKB/EIF4E2/BAD/EIF4EBP1/PHKG2/TSC1/SHC1/PDPK1/CALML5/GSK3B/PRKAB2/GRB2/KRAS/SOS2/ARAF/PRKAG1/SREBF1/INS/RPS6KB1/PPP1CB/AKT1/BRAF/PPP1R3F/PYGM/PPP1R3D/RHOQ/PCK2/PTPRF/PHKB/PHKA2/NRAS/PIK3R3/EXOC7/PRKAR2B/SOS1/HK1/PRKACG/CALM1/MAPK1/MAPK10/IRS1/FBP1/MTOR/MAPK3/G6PC3/TSC2	49
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	76/2990	212/8135	0.6345	1	0.9392	AKT2/MIR29C/GNAI2/RB1/MIRLET7F1/BAD/IKBKE/EIF4EBP1/PTGES3/STAT5A/ADCY7/FOS/KLF4/ATF6B/FGF3/MGST3/KPNA1/GRB2/AHR/MIR29B2/GSTA4/KRAS/SOS2/HSP90AA1/CHRNA7/JUN/RPS6KB1/KPNA4/AKT1/ARRB1/ADRB2/HSP90AB1/CCND1/MGST1/FGF6/GSTA2/RELA/FGF20/CREB3L1/ESR1/PRKCB/PAQR8/UGT2B11/NRAS/RXRB/BCL2/PIK3R3/KPNA7/CHRNB4/CDC6/HSP90B1/ADCY4/MIR141/CREB1/SOS1/ARRB2/MIRLET7G/PRKACG/NOTCH2/MAPK1/CACNA1F/ADRB3/VDR/CHRNB2/RPS6KA3/GSTA5/CHRNA3/MTOR/CYP3A4/CACNA1C/MAPK3/ATF2/CREB3L4/EPHX4/GSTM1/ATF4	76
KEGG	hsa05017	Spinocerebellar ataxia	51/2990	143/8135	0.6382	1	0.9392	ATG101/AKT2/BECN1/NOP56/KAT5/CIC/SLC25A4/SP1/PSMA1/PSMA2/ULK2/PLCB2/RBPJ/PSMA6/BEAN1/PSMA5/AMBRA1/PSMD1/ATXN10/SLC1A6/GNAQ/ATXN2L/PSMB6/AFG3L2/AKT1/PSMD9/PSMA4/SPTBN2/MAP3K5/PSMC1/MYOD1/NFYA/PRKCB/PSMC4/ATXN3/OMA1/PUM1/VDAC2/PSMB5/PSMD7/TRPC3/PIK3R3/RB1CC1/KCNC3/WIPI1/MAPK10/TBPL1/PSMB7/ADRM1/MTOR/ITPR1	51
KEGG	hsa00450	Selenocompound metabolism	6/2990	17/8135	0.6388	1	0.9392	TXNRD2/MTR/MARS2/SEPHS2/TXNRD1/CTH	6
KEGG	hsa04728	Dopaminergic synapse	47/2990	132/8135	0.6406	1	0.9392	AKT2/GNAI2/PPP2R2D/FOS/PLCB2/ATF6B/CALML5/GSK3B/GNAQ/PPP3CB/GNG7/GNG5/KIF5B/PPP2R5D/GNAL/PPP2R2A/PPP1CB/PPP2R3B/AKT1/ARRB1/PPP2R5A/PPP2R5E/GNB1/PPP3CA/CREB3L1/PRKCB/MAOA/KIF5A/MAPK12/CAMK2A/GNG11/CREB1/ARRB2/SLC18A1/PRKACG/CALM1/PPP1R1B/CAMK2D/MAPK10/MAPK11/PPP2R2C/GNGT1/CACNA1C/ATF2/CREB3L4/ITPR1/ATF4	47
KEGG	hsa04922	Glucagon signaling pathway	38/2990	107/8135	0.641	1	0.9392	PRKAB1/AKT2/PGAM4/LDHB/PGAM2/SIRT1/PHKG2/PLCB2/CALML5/PRKAB2/PDHA2/GNAQ/PPP3CB/PRKAG1/PPP3R1/GCGR/AKT1/PDHB/PYGM/PPP3CA/PCK2/CREB3L1/CPT1C/CPT1A/PHKB/PHKA2/CAMK2A/PDHA1/CREB1/PRKACG/CALM1/CAMK2D/FBP1/ATF2/CREB3L4/G6PC3/ITPR1/ATF4	38
KEGG	hsa00100	Steroid biosynthesis	7/2990	20/8135	0.6465	1	0.9392	LSS/NSDHL/CYP27B1/CEL/SC5D/DHCR7/FDFT1	7
KEGG	hsa04015	Rap1 signaling pathway	75/2990	210/8135	0.6495	1	0.9392	AKT2/RAP1A/GNAI2/CSF1/CTNNB1/MRAS/EPHA2/VAV1/PFN3/ADCY7/IGF1/FGFR2/PLCG1/PLCB2/FGF3/CALML5/RAP1B/TIAM1/KRAS/EFNA3/GNAQ/FARP2/SIPA1L3/THBS1/BCAR1/FGFR4/RASSF5/CSF1R/INS/RAPGEF2/AKT1/HGF/BRAF/RAPGEF6/VEGFC/CDH1/FGF6/LPAR2/RAP1GAP/PDGFC/RALA/FGF20/NGF/PRKCB/LAT/LCP2/ACTB/NRAS/MAPK12/EFNA2/PFN4/MAP2K3/PIK3R3/LPAR5/RRAS/RGS14/ADCY4/ADORA2A/ITGB2/PLCE1/CALM1/MAPK1/PDGFB/CTNND1/PGF/FGF23/MAPK11/ITGAL/FGF21/NGFR/MAPK3/ARAP3/ANGPT2/SKAP1/VASP	75
KEGG	hsa04940	Type I diabetes mellitus	15/2990	43/8135	0.6559	1	0.9392	TNF/FASLG/HSPD1/INS/PTPRN2/CD28/LTA/PRF1/HLA-DRA/HLA-DMB/HLA-C/CPE/GZMB/ICA1/IL2	15
KEGG	hsa04975	Fat digestion and absorption	15/2990	43/8135	0.6559	1	0.9392	PLA2G1B/PNLIPRP2/GOT2/APOA1/CLPS/SLC27A1/CEL/PLA2G10/PLA2G2A/FABP1/ACAT1/ABCA1/PNLIP/PLA2G3/SCARB1	15
KEGG	hsa04914	Progesterone-mediated oocyte maturation	36/2990	102/8135	0.6567	1	0.9392	SPDYE1/AKT2/GNAI2/ADCY7/IGF1/CDC25B/MAD2L1/KRAS/ANAPC7/ARAF/HSP90AA1/CDC26/INS/BUB1/AKT1/BRAF/CDC23/HSP90AB1/SPDYE2/MAPK12/PIK3R3/ADCY4/STK10/SPDYE5/PRKACG/CCNB3/MAPK1/CDK1/MAPK10/PLK1/RPS6KA3/MAPK11/MAD1L1/CCNA1/CCNB2/MAPK3	36
KEGG	hsa05142	Chagas disease	36/2990	102/8135	0.6567	1	0.9392	AKT2/IKBKB/TNF/GNAI2/PPP2R2D/FASLG/CHUK/C3/FOS/PLCB2/IL10/TICAM1/GNAQ/TRAF6/GNAL/PPP2R2A/JUN/AKT1/CALR/RELA/TNFRSF1A/MAPK12/BDKRB2/PIK3R3/CD3D/CASP8/MAPK1/MAPK10/FADD/MAPK11/GNA15/PPP2R2C/C1QC/MAPK3/IL2/C1QA	36
KEGG	hsa05146	Amoebiasis	36/2990	102/8135	0.6567	1	0.9392	RAB7A/PRDX1/TNF/COL4A4/PLCB2/IL10/COL4A3/SERPINB13/GNAQ/CD1E/CD1D/GNAL/SERPINB6/CD1A/CASP3/LAMB1/RAB5C/RELA/ACTN1/PRKCB/ARG2/COL4A1/PIK3R3/COL1A2/FN1/ITGB2/PTK2/PRKACG/C8G/COL4A5/SERPINB4/GNA15/LAMA3/COL1A1/SERPINB10/RAB5A	36
KEGG	hsa05416	Viral myocarditis	21/2990	60/8135	0.658	1	0.9392	CAV1/MYH6/FYN/DAG1/CASP3/CD55/CD28/CCND1/PRF1/SGCA/CD40/EIF4G2/ACTB/HLA-DRA/SGCB/HLA-DMB/ITGB2/CASP8/HLA-C/EIF4G1/ITGAL	21
KEGG	hsa04950	Maturity onset diabetes of the young	9/2990	26/8135	0.6606	1	0.9392	HHEX/PAX4/BHLHA15/ONECUT1/HES1/INS/MNX1/PDX1/MAFA	9
KEGG	hsa00310	Lysine degradation	22/2990	63/8135	0.6644	1	0.9392	SETDB1/DLST/KMT2D/EHMT2/PHYKPL/SETMAR/PRDM7/AADAT/EHHADH/AASS/EZH2/EZH1/PRDM16/SETD2/HADHA/DLD/DHTKD1/ECHS1/ACAT1/SETD1A/TMLHE/SETD1B	22
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	34/2990	97/8135	0.673	1	0.9392	AKT2/VAV1/PLA2G6/PLCG1/PLD2/ARPC1B/FCGR3A/CFL1/WASF2/ASAP1/AMPH/DOCK1/RPS6KB1/AKT1/PIP5K1B/PLA2G4C/PLA2G4D/PIP5K1A/PRKCB/LAT/PLCG2/ARPC5L/ARF6/PIK3R3/DNM2/ARPC1A/MAPK1/WASF3/ACTR3B/MAPK3/ARPC5/MYO10/LYN/VASP	34
KEGG	hsa01240	Biosynthesis of cofactors	54/2990	153/8135	0.6762	1	0.9392	UMPS/COX15/COQ3/LIAS/UGP2/RDH11/AK5/GGCX/NFS1/COQ6/COQ2/IDO1/MPI/MOCS1/CAD/KMO/COQ7/MTHFD2/RDH12/FPGS/PNPO/PMM1/PANK2/GCLM/FECH/SHMT1/AKR1A1/CMPK2/GMPPA/FLAD1/AK4/COX10/GPHN/UGT2B11/PPCS/PPOX/PMM2/DHODH/SDR16C5/MAT2B/DLD/COQ5/ALAS1/CMPK1/AK2/GSS/MTHFD1L/LIPT2/BCAT2/CPOX/MTHFD1/OXSM/VKORC1L1/PANK1	54
KEGG	hsa04062	Chemokine signaling pathway	68/2990	192/8135	0.6772	1	0.9392	AKT2/RAP1A/IKBKB/GNAI2/BAD/STAT2/VAV1/CHUK/ADCY7/PLCG1/PLCB2/SHC1/CX3CR1/NFKBIB/CCR7/RAP1B/GSK3B/CCR3/GRB2/CCR4/TIAM1/KRAS/SOS2/GNAQ/GNG7/GNG5/BCAR1/PIK3R6/JAK3/CCL17/AKT1/ARRB1/CCR2/BRAF/CXCL13/CXCL10/FOXO3/GNB1/RELA/CCL16/PRKCB/PIK3R5/PLCG2/CCR8/NRAS/GNG11/FGR/PIK3R3/PXN/CXCR3/ADCY4/SOS1/ARRB2/PTK2/CCL26/PRKACG/MAPK1/ROCK2/GRK5/CXCL11/CXCR5/GNGT1/MAPK3/CCR1/LYN/XCL2/CCL22/XCR1	68
KEGG	hsa04918	Thyroid hormone synthesis	26/2990	75/8135	0.6875	1	0.9392	ADCY7/PLCB2/ATF6B/GPX6/TTF2/GNAQ/ATP1A4/TTF1/TSHR/DUOX2/HSPA5/CREB3L1/PRKCB/ATP1B2/ATP1A1/HSP90B1/ADCY4/CREB1/PRKACG/GPX2/GPX7/ATF2/CREB3L4/GSR/ITPR1/ATF4	26
KEGG	hsa00590	Arachidonic acid metabolism	21/2990	61/8135	0.6924	1	0.9392	AKR1C3/PTGES3/CBR1/PLA2G6/GPX6/PLA2G1B/CYP2C9/GGT5/PLA2G4C/PLA2G4D/CYP2C19/CYP2U1/PLA2G10/PLA2G2A/CYP2C8/GPX2/CYP2E1/GPX7/CBR3/PLA2G3/PTGES2	21
KEGG	hsa04390	Hippo signaling pathway	55/2990	157/8135	0.7021	1	0.9392	YWHAZ/PPP2R2D/SMAD4/CTNNB1/MOB1A/DVL2/CCND2/DVL3/BBC3/LLGL1/ID2/CSNK1D/GSK3B/DLG5/FZD9/APC2/BTRC/DLG1/YWHAE/PPP2R2A/FBXW11/PPP1CB/TCF7L2/BMPR2/WNT4/FZD6/FZD7/CCND1/AREG/CDH1/NKD2/GLI2/BIRC2/SMAD7/YWHAB/TEAD2/ACTB/TCF7/GDF6/WNT10A/RASSF1/ITGB2/BMP2/CTNNA2/DLG2/CTNNA1/GDF7/BMP5/CTNNA3/PPP2R2C/WNT2/BMP7/WTIP/WNT9B/YWHAQ	55
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	24/2990	70/8135	0.7077	1	0.9392	IKBKB/TCIRG1/MAP3K14/CHUK/ADAM10/PLCG1/ATP6V1C2/CSK/GIT1/ATP6V1B1/JUN/CASP3/ATP6V0E2/RELA/ATP6V1G3/PLCG2/ATP6AP1/MAPK12/ATP6V0B/ATP6V1A/NOD1/MAPK10/MAPK11/LYN	24
KEGG	hsa00030	Pentose phosphate pathway	10/2990	30/8135	0.7145	1	0.9392	ALDOC/TKTL1/TALDO1/GLYCTK/DERA/PGM1/PGM2/GPI/ALDOB/FBP1	10
KEGG	hsa00051	Fructose and mannose metabolism	11/2990	33/8135	0.7183	1	0.9392	GMDS/MPI/ALDOC/PMM1/GMPPA/TSTA3/PMM2/HK1/ALDOB/FBP1/AKR1B1	11
KEGG	hsa00380	Tryptophan metabolism	14/2990	42/8135	0.7297	1	0.9392	DLST/IDO1/KMO/AADAT/EHHADH/AANAT/IL4I1/ASMT/MAOA/HADHA/DLD/DHTKD1/ECHS1/ACAT1	14
KEGG	hsa04022	cGMP-PKG signaling pathway	58/2990	167/8135	0.734	1	0.9392	AKT2/NPR2/GNAI2/KCNMB1/SLC25A4/BAD/PLN/ADCY7/AGTR1/PLCB2/ATF6B/NFATC1/PPP1R12A/CALML5/NOS3/MYH6/MEF2D/GNAQ/PPP3CB/ATP1A4/PIK3R6/ADRA2B/PPP3R1/INS/CNGB1/PPP1CB/AKT1/ADRA2A/ADRB2/ADRA1D/PPP3CA/KCNJ8/ATP2B3/CREB3L1/PIK3R5/ATP1B2/ATP2B2/VDAC2/ATP1A1/BDKRB2/SRF/ADCY4/CREB1/CALM1/NPPB/MAPK1/CACNA1F/ADRB3/ROCK2/IRS1/MEF2B/CACNA1C/MAPK3/ATF2/CREB3L4/VASP/ITPR1/ATF4	58
KEGG	hsa04520	Adherens junction	24/2990	71/8135	0.7373	1	0.9392	SMAD4/CTNNB1/FYN/WASF2/FARP2/PTPN6/ERBB2/TCF7L2/CDH1/ACTN1/PTPRF/ACTB/TCF7/WASL/CSNK2B/YES1/CTNNA2/MAPK1/WASF3/CTNND1/CTNNA1/CTNNA3/LMO7/MAPK3	24
KEGG	hsa04723	Retrograde endocannabinoid signaling	51/2990	148/8135	0.7474	1	0.9392	ND6/GNAI2/NDUFS3/NDUFA9/ND5/NDUFB3/NDUFB10/NDUFB6/NDUFV2/ADCY7/PLCB2/NDUFA12/NDUFA2/ND2/ND4/GABRB3/ND1/NDUFC2/DAGLB/ABHD6/GABRP/GABRD/GNAQ/NDUFS4/NDUFA6/GNG7/GNG5/NDUFS1/NDUFB5/NDUFB1/GNB1/PRKCB/NDUFB11/NDUFAB1/MAPK12/GNG11/NDUFV1/NDUFA10/ND3/ADCY4/GABRA2/PRKACG/GABRA3/MAPK1/CACNA1F/MAPK10/MAPK11/GNGT1/CACNA1C/MAPK3/ITPR1	51
KEGG	hsa00220	Arginine biosynthesis	7/2990	22/8135	0.7551	1	0.9392	NOS3/GOT2/ARG2/GOT1L1/GLS2/ACY1/NOS1	7
KEGG	hsa00650	Butanoate metabolism	9/2990	28/8135	0.7559	1	0.9392	HMGCL/EHHADH/BDH2/HMGCS1/HADHA/ECHS1/AACS/ACAT1/L2HGDH	9
KEGG	hsa00052	Galactose metabolism	10/2990	31/8135	0.7572	1	0.9392	UGP2/GALT/GLA/GALE/PGM1/PGM2/HK1/GALM/G6PC3/AKR1B1	10
KEGG	hsa00360	Phenylalanine metabolism	5/2990	16/8135	0.7589	1	0.9392	GOT2/IL4I1/MAOA/GOT1L1/AOC2	5
KEGG	hsa00430	Taurine and hypotaurine metabolism	5/2990	16/8135	0.7589	1	0.9392	CSAD/GGT7/FMO4/FMO3/GGT5	5
KEGG	hsa01200	Carbon metabolism	39/2990	115/8135	0.7673	1	0.9392	DLST/PGAM4/PGAM2/SUCLG1/ACSS1/ACOX3/CS/IDH3B/DLAT/GLDC/ALDOC/ME3/PDHA2/OGDH/TKTL1/GOT2/ACO1/PHGDH/SHMT1/PDHB/TALDO1/ENO1/ACSS2/GLYCTK/FH/IDH1/GOT1L1/PDHA1/DLD/GPI/ADPGK/HK1/ALDOB/ECHS1/FBP1/ACAT1/SDHC/PC/AGXT	39
KEGG	hsa04930	Type II diabetes mellitus	15/2990	46/8135	0.7677	1	0.9392	SOCS4/IKBKB/TNF/INS/PIK3R3/CACNA1G/HK1/MAPK1/MAPK10/IRS1/PDX1/MTOR/CACNA1C/MAPK3/MAFA	15
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	33/2990	98/8135	0.7696	1	0.9392	PTGER2/PTGER4/PLA2G6/ADCY7/IGF1/PLCG1/PLCB2/CALML5/GNAQ/HRH1/PPP1CB/PLA2G4C/PLA2G4D/ASIC5/NGF/PRKCB/PLCG2/MAPK12/CAMK2A/BDKRB2/MAP2K3/PIK3R3/F2RL1/ADCY4/TRPV4/PRKACG/CALM1/CAMK2D/MAPK10/HTR2A/MAPK11/TRPV2/ITPR1	33
KEGG	hsa00920	Sulfur metabolism	3/2990	10/8135	0.7748	1	0.9392	SUOX/ETHE1/IMPAD1	3
KEGG	hsa04620	Toll-like receptor signaling pathway	35/2990	104/8135	0.7759	1	0.9392	AKT2/IKBKB/TNF/TIRAP/IRF7/IKBKE/TAB1/CHUK/FOS/IFNA21/IRF5/TICAM1/IRF3/TRAF6/JUN/MAP3K8/AKT1/CXCL10/IFNA2/IFNA5/RELA/CD40/MAPK12/MAP2K3/PIK3R3/CASP8/TRAF3/IFNA17/MAPK1/MAPK10/FADD/MAPK11/CXCL11/LY96/MAPK3	35
KEGG	hsa00240	Pyrimidine metabolism	19/2990	58/8135	0.7778	1	0.9392	UMPS/ENTPD4/ENPP3/TYMS/TK2/CAD/CANT1/NT5C1A/CMPK2/ENTPD5/DHODH/NUDT2/TK1/RRM2/ENTPD1/CMPK1/DCK/ENPP1/NT5DC4	19
KEGG	hsa00561	Glycerolipid metabolism	20/2990	61/8135	0.7804	1	0.9392	DGKZ/GPAM/AGPAT5/DGKK/LPIN3/PNLIPRP2/GLA/DGKA/AKR1A1/GLYCTK/DGKH/MBOAT1/AGK/CEL/MBOAT2/MOGAT1/LPIN1/PNPLA2/PNLIP/AKR1B1	20
KEGG	hsa05410	Hypertrophic cardiomyopathy	30/2990	90/8135	0.7832	1	0.9392	PRKAB1/TNF/CACNB1/IGF1/ITGA10/ITGB8/TNNI3/PRKAB2/MYH6/ITGAV/TPM3/DAG1/PRKAG1/ITGA5/MYL2/TPM1/TTN/SGCA/CACNG4/CACNG6/ACTB/CACNB3/SGCB/CACNA2D2/CACNA1F/TNNT2/ITGB7/CACNA1C/AGT/TPM4	30
KEGG	hsa04971	Gastric acid secretion	25/2990	76/8135	0.7931	1	0.9392	GNAI2/ADCY7/PLCB2/CHRM3/CALML5/GNAQ/ATP1A4/SST/KCNJ2/SSTR2/SLC9A1/PRKCB/ATP1B2/ATP4B/ACTB/CAMK2A/ATP1A1/ADCY4/PRKACG/CALM1/CAMK2D/KCNK10/SLC4A2/SLC9A4/ITPR1	25
KEGG	hsa04217	Necroptosis	54/2990	159/8135	0.7934	1	0.9392	RIPK3/USP21/CHMP4A/TNF/RNF31/SLC25A4/CHMP2A/CHMP3/PPID/FASLG/RBCK1/STAT2/AIFM1/STAT5A/HMGB1/IFNA21/TNFRSF10B/TNFRSF10A/TICAM1/HSP90AA1/ZBP1/SPATA2/JAK3/CHMP7/PLA2G4C/HSP90AB1/IFNA2/TNFSF10/PLA2G4D/STAT6/PYGM/IFNA5/TRADD/BIRC2/PPIA/DNM1L/CHMP2B/TNFRSF1A/BCL2/CAMK2A/VDAC2/SMPD1/CHMP1A/TRAF5/IRF9/CASP8/IFNA17/CAMK2D/MAPK10/FADD/MLKL/CYBB/VPS4A/TNFAIP3	54
KEGG	hsa05330	Allograft rejection	12/2990	38/8135	0.7958	1	0.9392	TNF/FASLG/IL10/IL4/CD28/PRF1/CD40/HLA-DRA/HLA-DMB/HLA-C/GZMB/IL2	12
KEGG	hsa00515	Mannose type O-glycan biosynthesis	7/2990	23/8135	0.7994	1	0.9392	POMGNT1/POMT1/FKRP/ST3GAL3/B3GAT2/B3GALNT2/POMT2	7
KEGG	hsa04614	Renin-angiotensin system	7/2990	23/8135	0.7994	1	0.9392	KLK1/LNPEP/AGTR1/ATP6AP2/AGTR2/PREP/AGT	7
KEGG	hsa05110	Vibrio cholerae infection	16/2990	50/8135	0.8003	1	0.9392	TCIRG1/PLCG1/TJP2/ATP6V1C2/ATP6V1B1/ARF1/ATP6V0E2/ATP6V1G3/PLCG2/ATP6AP1/SEC61A1/ACTB/ATP6V0B/PRKACG/ATP6V1A/SEC61G	16
KEGG	hsa04670	Leukocyte transendothelial migration	38/2990	114/8135	0.8047	1	0.9392	RAP1A/GNAI2/MYL12B/CTNNB1/VAV1/PLCG1/RAP1B/MYL7/TXK/CLDN15/BCAR1/RASSF5/PECAM1/MYL2/CD99L2/ACTN1/CLDN10/PRKCB/PLCG2/CLDN14/ACTB/MAPK12/PIK3R3/PXN/MSN/ITGB2/PTK2/CTNNA2/ROCK2/CTNND1/CTNNA1/MAPK11/CYBB/ARHGAP5/CTNNA3/ITGAL/CLDN16/VASP	38
KEGG	hsa04921	Oxytocin signaling pathway	52/2990	154/8135	0.8048	1	0.9392	PRKAB1/NPR2/GNAI2/CACNB1/ADCY7/FOS/PPP1R12C/PLCB2/MYL6B/NFATC1/PPP1R12A/CALML5/PRKAB2/NOS3/KRAS/GNAQ/PPP3CB/EEF2/PIK3R6/PRKAG1/KCNJ12/PPP3R1/JUN/PPP1CB/KCNJ2/PLA2G4C/MAP2K5/CCND1/OXTR/PLA2G4D/CDKN1A/PPP3CA/PRKCB/PIK3R5/CACNG4/CACNG6/ACTB/NRAS/CAMK2A/CACNB3/ADCY4/CACNA2D2/PRKACG/CALM1/MAPK1/CAMK2D/CACNA1F/ROCK2/CAMK1/CACNA1C/MAPK3/ITPR1	52
KEGG	hsa05321	Inflammatory bowel disease	21/2990	65/8135	0.8086	1	0.9392	IL23A/TNF/IL21R/NOD2/IL4R/IL10/NFATC1/IL21/JUN/IL4/STAT6/FOXP3/RELA/IL22/HLA-DRA/HLA-DMB/IL12RB2/IL18R1/IL17A/IL18RAP/IL2	21
KEGG	hsa05145	Toxoplasmosis	37/2990	112/8135	0.821	1	0.9392	AKT2/IKBKB/TNF/GNAI2/BAD/TAB1/CHUK/IL10/PDPK1/NFKBIB/HSPA1L/TRAF6/PIK3R6/CASP3/IL10RB/AKT1/LAMB1/RELA/IL10RA/BIRC2/CD40/PIK3R5/TNFRSF1A/HLA-DRA/MAPK12/BCL2/MAP2K3/HLA-DMB/CASP8/MAPK1/MAPK10/CIITA/MAPK11/LY96/LAMA3/MAPK3/HSPA6	37
KEGG	hsa04915	Estrogen signaling pathway	46/2990	138/8135	0.8235	1	0.9392	AKT2/GNAI2/SP1/ADCY7/FOS/PLCB2/KRT9/ATF6B/SHC1/HSPA1L/CALML5/NOS3/RARA/GRB2/KRAS/SOS2/GNAQ/HSP90AA1/JUN/GABBR1/AKT1/HSP90AB1/KRT34/CREB3L1/ESR1/GPER1/NRAS/BCL2/PIK3R3/HSP90B1/ADCY4/CREB1/SOS1/PRKACG/CALM1/MAPK1/KRT14/KRT16/POMC/KRT25/MAPK3/ATF2/HSPA6/CREB3L4/ITPR1/ATF4	46
KEGG	hsa05332	Graft-versus-host disease	13/2990	42/8135	0.8266	1	0.9392	TNF/FASLG/CD28/KLRD1/PRF1/HLA-DRA/KIR3DL2/HLA-DMB/KIR3DL3/HLA-C/GZMB/KIR2DL1/IL2	13
KEGG	hsa00513	Various types of N-glycan biosynthesis	12/2990	39/8135	0.8269	1	0.9392	ALG11/ALG3/ALG12/STT3A/ALG1/ST3GAL3/TUSC3/MAN1C1/MAN1A1/MAN2A2/CHST8/B4GALNT4	12
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	11/2990	36/8135	0.8276	1	0.9392	SIRT1/ENPP3/NNMT/NT5C1A/NMRK2/SIRT7/SIRT6/SIRT2/SIRT4/ENPP1/NT5DC4	11
KEGG	hsa01212	Fatty acid metabolism	18/2990	57/8135	0.8289	1	0.9392	MCAT/SCP2/ACOX3/HSD17B12/EHHADH/ELOVL1/ACADVL/ELOVL5/CPT1C/CPT1A/ACAA1/CPT2/HADHA/ECHS1/ACSBG1/ACAT1/ACSL3/OXSM	18
KEGG	hsa04916	Melanogenesis	33/2990	101/8135	0.8313	1	0.9392	GNAI2/CTNNB1/DVL2/DVL3/ADCY7/PLCB2/CALML5/GSK3B/KRAS/FZD9/GNAQ/TCF7L2/WNT4/FZD6/FZD7/CREB3L1/PRKCB/NRAS/CAMK2A/TCF7/WNT10A/ADCY4/CREB1/PRKACG/CALM1/MAPK1/CAMK2D/POMC/WNT2/MAPK3/WNT9B/CREB3L4/DCT	33
KEGG	hsa04060	Cytokine-cytokine receptor interaction	101/2990	295/8135	0.8352	1	0.9392	IL23A/TNF/TNFRSF14/CSF1/EDA/IL21R/CLCF1/IL2RB/IL27RA/FASLG/TNFRSF10D/ACVR2B/ACKR3/IL4R/IL6R/IL10/IL36A/IFNA21/TNFRSF10B/TNFRSF10A/CX3CR1/CCR7/CCR3/TNFRSF17/CCR4/LEP/CD70/IL11RA/IL21/TNFSF15/ACVR1C/IL17B/CSF1R/IL7/EDAR/IL16/CCL17/IL10RB/IL4/BMPR2/CCR2/CXCL13/LTA/ACVR1B/IL5RA/CXCL10/TNFRSF25/IFNA2/TNFSF10/EDA2R/IFNA5/TNFRSF1B/IL10RA/EPOR/CCL16/CD40/NGF/CRLF2/CSF2RB/CCR8/IL22/TNFRSF1A/IL22RA1/TNFSF13/IL17D/GDF6/CXCR3/LTBR/BMP15/IL12RB2/INHBE/BMP2/CCL26/IL18R1/IL13RA2/IFNA17/CTF1/LIF/GDF9/INHBB/CXCL11/IL3RA/CXCR5/GDF7/BMP5/IL20/IL15/IL17A/PRLR/BMP7/NGFR/CCR1/IL18RAP/GDF15/AMHR2/OSM/XCL2/CCL22/XCR1/IL2/INHBA	101
KEGG	hsa01230	Biosynthesis of amino acids	24/2990	75/8135	0.8359	1	0.9392	PGAM4/PGAM2/MTR/CS/IDH3B/ALDOC/TKTL1/GOT2/ACO1/PHGDH/SHMT1/PYCR2/TALDO1/ENO1/ARG2/IDH1/CBS/GOT1L1/MAT2B/ALDOB/ACY1/CTH/BCAT2/PC	24
KEGG	hsa04721	Synaptic vesicle cycle	25/2990	78/8135	0.8373	1	0.9392	TCIRG1/AP2B1/ATP6V1C2/SLC6A11/SLC6A12/SLC1A6/STX1B/DNM1/ATP6V1B1/AP2A2/SLC6A2/ATP6V0E2/SLC6A9/CLTB/SLC1A2/ATP6V1G3/STXBP1/CLTA/ATP6V0B/DNM2/SLC18A1/ATP6V1A/AP2M1/RAB3A/STX1A	25
KEGG	hsa04371	Apelin signaling pathway	46/2990	139/8135	0.8393	1	0.9392	PRKAB1/AKT2/BECN1/GNAI2/SMAD4/MRAS/EGR1/ADCY7/AGTR1/RRAS2/PLCB2/CALML5/PRKAB2/NOS3/KRAS/MEF2D/GNAQ/GNG7/GNG5/MYL4/PIK3R6/PRKAG1/RPS6KB1/AKT1/MYL2/CCND1/GNB1/CDH1/MAP1LC3B2/SLC9A1/PIK3R5/NRAS/GNG11/RRAS/KLF2/MAP1LC3C/ADCY4/PRKACG/CALM1/MAPK1/NOS1/MEF2B/GNGT1/MTOR/MAPK3/ITPR1	46
KEGG	hsa05414	Dilated cardiomyopathy	31/2990	96/8135	0.846	1	0.9392	TNF/CACNB1/PLN/ADCY7/IGF1/ITGA10/ITGB8/TNNI3/MYH6/ITGAV/TPM3/DAG1/ITGA5/MYL2/TPM1/TTN/SGCA/CACNG4/CACNG6/ACTB/CACNB3/SGCB/ADCY4/CACNA2D2/PRKACG/CACNA1F/TNNT2/ITGB7/CACNA1C/AGT/TPM4	31
KEGG	hsa04640	Hematopoietic cell lineage	32/2990	99/8135	0.8475	1	0.9392	TNF/CSF1/CD7/TFRC/IL4R/IL6R/FLT3LG/IL11RA/CD1E/CD1D/FCER2/CSF1R/IL7/ITGA5/CD1A/CD59/IL4/CD55/IL5RA/EPOR/FLT3/HLA-DRA/CD37/HLA-DMB/CD33/CD8B/GYPA/CD3D/CD24/CR1L/IL3RA/CR2	32
KEGG	hsa00061	Fatty acid biosynthesis	5/2990	18/8135	0.8503	1	0.9392	MCAT/OLAH/ACSBG1/ACSL3/OXSM	5
KEGG	hsa04270	Vascular smooth muscle contraction	44/2990	134/8135	0.8508	1	0.9392	NPR2/KCNMB1/MYH11/PLA2G6/ADCY7/AGTR1/PPP1R12C/PLCB2/MYL6B/ARHGEF1/PPP1R12A/PLA2G1B/CALML5/MYH10/GNAQ/ARAF/PPP1CB/BRAF/PLA2G4C/PLA2G4D/MYH14/ADRA1D/PRKCB/RAMP3/ARHGEF11/ADCY4/ADORA2A/PRKACG/CALM1/NPPB/PLA2G10/PLA2G2A/MAPK1/CACNA1F/MYH9/ROCK2/CALD1/ARHGEF12/AVP/CACNA1C/MAPK3/AGT/PLA2G3/ITPR1	44
KEGG	hsa05152	Tuberculosis	60/2990	180/8135	0.8512	1	0.9392	RAB7A/AKT2/IL23A/TNF/TIRAP/NFYC/BAD/TCIRG1/CASP10/C3/NOD2/IL10/IFNA21/CALML5/FCGR3A/KSR1/CYP27B1/PPP3CB/RFX5/TRAF6/HSPD1/LSP1/PPP3R1/CASP3/IL10RB/AKT1/RAB5C/IFNA2/IFNA5/TRADD/PPP3CA/RELA/NFYA/IL10RA/ATP6AP1/TNFRSF1A/HLA-DRA/MAPK12/BCL2/CAMK2A/ATP6V0B/HLA-DMB/CREB1/ITGB2/CALM1/CASP8/IFNA17/MAPK1/CAMK2D/MAPK10/VDR/CIITA/FADD/MAPK11/CORO1A/CR1L/ARHGEF12/APAF1/MAPK3/RAB5A	60
KEGG	hsa00565	Ether lipid metabolism	15/2990	49/8135	0.8519	1	0.9392	PAFAH2/PLA2G6/ENPP2/CEPT1/PLD2/PLA2G1B/GDPD1/LPCAT4/PAFAH1B2/PLA2G4C/PLA2G4D/PLD4/PLA2G10/PLA2G2A/PLA2G3	15
KEGG	hsa01232	Nucleotide metabolism	27/2990	85/8135	0.8586	1	0.9392	ITPA/ENTPD4/AK5/ENPP3/TYMS/TK2/GMPR2/LACC1/NTPCR/CANT1/NT5C1A/CMPK2/AK4/AMPD2/ENTPD5/APRT/TK1/RRM2/ENTPD1/ADA/CMPK1/GUK1/GMPS/AK2/DCK/ENPP1/NT5DC4	27
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2990	15/8135	0.8609	1	0.9392	ST8SIA1/GLA/B3GALNT1/FUT1	4
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2990	15/8135	0.8609	1	0.9392	ST8SIA1/ST3GAL5/ST8SIA5/ST6GALNAC3	4
KEGG	hsa04142	Lysosome	43/2990	132/8135	0.8636	1	0.9392	ARSA/LAMP3/AP3S1/TCIRG1/ENTPD4/IDUA/PLA2G15/SGSH/PSAP/CTSC/GGA1/CLN3/CTSW/SLC17A5/CTSE/AP3B1/AP4B1/CLN5/CD164/NPC2/GGA3/AP3M1/NAGPA/GLA/NPC1/ACP2/AP4M1/AP1S1/CLTB/GNPTAB/NEU1/AP4S1/AP3M2/ATP6AP1/CLTA/ATP6V0B/SMPD1/CTSL/DNASE2/AP1S2/GGA2/CD68/AP1G2	43
KEGG	hsa05320	Autoimmune thyroid disease	16/2990	53/8135	0.8733	1	0.9392	FASLG/IL10/IFNA21/IL4/CD28/TSHR/IFNA2/PRF1/IFNA5/CD40/HLA-DRA/HLA-DMB/IFNA17/HLA-C/GZMB/IL2	16
KEGG	hsa05140	Leishmaniasis	24/2990	77/8135	0.8737	1	0.9392	TNF/EEF1A2/EEF1A1/TAB1/C3/FOS/IL10/NFKBIB/FCGR3A/TRAF6/PTPN6/JUN/IL4/RELA/PRKCB/HLA-DRA/MAPK12/HLA-DMB/ITGB2/MAPK1/MAPK11/CR1L/CYBB/MAPK3	24
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	24/2990	77/8135	0.8737	1	0.9392	CTNNB1/CACNB1/ITGA10/ITGB8/ITGAV/DAG1/ITGA5/TCF7L2/SGCA/CACNG4/CACNG6/ACTB/TCF7/JUP/CACNB3/SGCB/CACNA2D2/CTNNA2/CACNA1F/DSP/CTNNA1/CTNNA3/ITGB7/CACNA1C	24
KEGG	hsa00514	Other types of O-glycan biosynthesis	14/2990	47/8135	0.875	1	0.9392	LFNG/POC1B-GALNT4/POMT1/MFNG/POFUT1/GALNT6/ST3GAL3/GALNT12/GALNT11/POFUT2/GALNT5/POMT2/GXYLT1/GALNT15	14
KEGG	hsa04911	Insulin secretion	27/2990	86/8135	0.8754	1	0.9392	KCNMB1/ADCY7/PLCB2/ATF6B/CHRM3/GNAQ/ATP1A4/KCNN4/INS/FFAR1/CREB3L1/PRKCB/ATP1B2/CAMK2A/ATP1A1/ADCY4/CREB1/PRKACG/CAMK2D/CACNA1F/PDX1/RAB3A/STX1A/CACNA1C/ATF2/CREB3L4/ATF4	27
KEGG	hsa04924	Renin secretion	21/2990	69/8135	0.8898	1	0.9392	GNAI2/PTGER2/PTGER4/ORAI1/AGTR1/PLCB2/CALML5/GNAQ/PPP3CB/PPP3R1/KCNJ2/ADRB2/PPP3CA/CREB1/PRKACG/CALM1/CACNA1F/ADRB3/CACNA1C/AGT/ITPR1	21
KEGG	hsa04978	Mineral absorption	18/2990	60/8135	0.8908	1	0.9392	MT1H/SLC46A1/MT1HL1/MT1A/ATOX1/ATP1A4/MT1X/ATP7A/HMOX1/TF/ATP2B3/ATP1B2/ATP2B2/MT1F/ATP1A1/MT1G/VDR/SLC6A19	18
KEGG	hsa04970	Salivary secretion	29/2990	93/8135	0.8915	1	0.9392	ADCY7/PRB1/PLCB2/AMY2B/AMY2A/CHRM3/CALML5/GNAQ/ATP1A4/MUC7/KCNN4/ADRB2/ADRA1D/ATP2B3/SLC9A1/CST3/PRKCB/ATP1B2/ATP2B2/ATP1A1/ADCY4/PRKACG/CALM1/BEST2/ADRB3/CST4/SLC4A2/NOS1/ITPR1	29
KEGG	hsa04972	Pancreatic secretion	32/2990	102/8135	0.8932	1	0.9392	CTRL/RAP1A/ADCY7/PLCB2/AMY2B/AMY2A/CHRM3/PLA2G1B/RAP1B/GNAQ/CTRB2/ATP1A4/PNLIPRP2/ATP2B3/SLC9A1/PRKCB/ATP1B2/ATP2B2/CEL/ATP1A1/ADCY4/SLC4A4/PRSS1/PLA2G10/PLA2G2A/TPCN2/SLC4A2/CPA1/PNLIP/PLA2G3/RAB11A/ITPR1	32
KEGG	hsa00330	Arginine and proline metabolism	15/2990	51/8135	0.8935	1	0.9392	NOS3/CKMT2/L3HYPDH/GOT2/SMS/PYCR2/AZIN2/P4HA2/MAOA/ARG2/GOT1L1/LAP3/ODC1/CKB/NOS1	15
KEGG	hsa00280	Valine, leucine and isoleucine degradation	14/2990	48/8135	0.8949	1	0.9392	HMGCL/IVD/DBT/EHHADH/IL4I1/HMGCS1/AUH/ACAA1/HADHA/DLD/ECHS1/AACS/BCAT2/ACAT1	14
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	6/2990	23/8135	0.9025	1	0.9392	ATP1A4/PCK2/ATP1B2/ATP1A1/SLC4A4/GLS2	6
KEGG	hsa00350	Tyrosine metabolism	10/2990	36/8135	0.9043	1	0.9392	GOT2/IL4I1/FAH/MAOA/GOT1L1/ADH1A/AOC2/PNMT/DCT/ADH4	10
KEGG	hsa04512	ECM-receptor interaction	27/2990	88/8135	0.9044	1	0.9392	CHAD/COL4A4/ITGA10/ITGB8/COL4A3/HMMR/COL9A3/ITGAV/DAG1/THBS1/COL9A2/ITGA5/LAMB1/COL6A1/SDC1/SV2B/COL6A2/COL4A1/COL1A2/FN1/IBSP/COL2A1/COL9A1/COL4A5/ITGB7/LAMA3/COL1A1	27
KEGG	hsa04540	Gap junction	27/2990	88/8135	0.9044	1	0.9392	GNAI2/TUBA3C/MAP3K2/ADCY7/PLCB2/CSNK1D/GRB2/KRAS/SOS2/GNAQ/TUBA3E/MAP2K5/PDGFC/PRKCB/TUBB3/NRAS/ADCY4/SOS1/TUBB2A/PRKACG/MAPK1/CDK1/PDGFB/HTR2A/MAPK3/TUBB/ITPR1	27
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	34/2990	109/8135	0.9066	1	0.9392	WDR3/NOP56/NXF1/RIOK1/EMG1/DKC1/GNL3/PWP2/GNL2/LSG1/RBM28/POP1/GNL3L/NAT10/SBDS/NOL6/MDN1/RPP38/FBLL1/RPP25L/RPP25/NOP10/UTP14A/UTP6/HEATR1/NVL/CSNK2B/WDR43/NHP2/NXT1/FBL/POP4/GTPBP4/RIOK2	34
KEGG	hsa04020	Calcium signaling pathway	79/2990	240/8135	0.9073	1	0.9392	P2RX7/SLC25A4/PLN/PHKG2/ADCY7/ORAI1/AGTR1/FGFR2/PLCG1/PLCB2/FGF3/PLCD4/CHRM3/CALML5/NOS3/LTB4R2/GNAQ/PPP3CB/HRH1/FGFR4/GNAL/PPP3R1/ERBB2/CHRNA7/MCOLN3/HGF/VEGFC/ADRB2/OXTR/CACNA1I/ADRA1D/FGF6/PPP3CA/PDGFC/FGF20/ATP2B3/ITPKB/ITPKA/TPCN1/NGF/PRKCB/CYSLTR2/PLCG2/ATP2B2/PHKB/PTGER1/PHKA2/TNNC2/CAMK2A/VDAC2/GRPR/CYSLTR1/BDKRB2/ADCY4/ADORA2A/PLCE1/CHRM5/CACNA1G/CASQ2/PRKACG/CALM1/TPCN2/CAMK2D/CACNA1F/ADRB3/PDGFB/HTR2A/CAMK1/FGF23/NTRK2/ASPH/NOS1/GNA15/PLCD3/FGF21/CACNA1C/CASQ1/PLCD1/ITPR1	79
KEGG	hsa05030	Cocaine addiction	14/2990	49/8135	0.912	1	0.9392	GNAI2/ATF6B/FOSB/JUN/RELA/CREB3L1/MAOA/CREB1/SLC18A1/PRKACG/PPP1R1B/ATF2/CREB3L4/ATF4	14
KEGG	hsa00062	Fatty acid elongation	7/2990	27/8135	0.9177	1	0.9392	HSD17B12/ELOVL1/ELOVL5/THEM5/HADHA/ECHS1/ACOT7	7
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2990	27/8135	0.9177	1	0.9392	ST8SIA1/B3GNT2/ST3GAL3/B3GALNT1/ST3GAL6/FUT1/B3GALT2	7
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	7/2990	27/8135	0.9177	1	0.9392	SCP2/ACOX3/HSD17B12/ELOVL1/ELOVL5/ACAA1/ACOT7	7
KEGG	hsa04966	Collecting duct acid secretion	7/2990	27/8135	0.9177	1	0.9392	TCIRG1/ATP6V1C2/ATP6V1B1/ATP6V0E2/ATP6V1G3/ATP4B/ATP6V1A	7
KEGG	hsa04380	Osteoclast differentiation	40/2990	128/8135	0.9197	1	0.9392	AKT2/IKBKB/TNF/CSF1/STAT2/MAP3K14/TAB1/CHUK/FOS/NFATC1/FYN/GRB2/FCGR3A/FOSB/PPP3CB/TRAF6/NFKB2/CSF1R/PPP3R1/JUN/FOSL1/AKT1/JUNB/PPP3CA/RELA/PLCG2/LCP2/TNFRSF1A/MAPK12/PIK3R3/CREB1/IRF9/FHL2/LILRB1/MAPK1/MAPK10/LILRA1/MAPK11/BTK/MAPK3	40
KEGG	hsa00120	Primary bile acid biosynthesis	4/2990	17/8135	0.9214	1	0.9392	SCP2/CYP8B1/HSD3B7/SLC27A5	4
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	10/2990	37/8135	0.9222	1	0.9392	PPAT/NAT8L/GFPT1/CAD/GOT2/IL4I1/GOT1L1/GLS2/ASRGL1/AGXT	10
KEGG	hsa05143	African trypanosomiasis	10/2990	37/8135	0.9222	1	0.9392	TNF/FASLG/PLCB2/IL10/IDO1/GNAQ/APOA1/PRKCB/F2RL1/APOL1	10
KEGG	hsa04979	Cholesterol metabolism	14/2990	50/8135	0.9268	1	0.9392	LCAT/APOA2/VAPA/ANGPTL4/MYLIP/NPC2/APOA1/NPC1/VDAC2/APOC3/VAPB/LDLRAP1/ABCA1/SCARB1	14
KEGG	hsa05144	Malaria	14/2990	50/8135	0.9268	1	0.9392	TNF/IL10/GYPC/CD81/THBS1/GYPB/HGF/PECAM1/SDC1/CD40/ITGB2/GYPA/CR1L/ITGAL	14
KEGG	hsa04973	Carbohydrate digestion and absorption	13/2990	47/8135	0.9289	1	0.9392	AKT2/PLCB2/AMY2B/AMY2A/ATP1A4/AKT1/PRKCB/ATP1B2/ATP1A1/PIK3R3/HK1/SLC37A4/G6PC3	13
KEGG	hsa05310	Asthma	8/2990	31/8135	0.9303	1	0.9392	TNF/IL10/MS4A2/IL4/CD40/HLA-DRA/FCER1A/HLA-DMB	8
KEGG	hsa05206	MicroRNAs in cancer	102/2990	310/8135	0.9333	1	0.9392	IKBKB/MIR29C/MIR330/UBE2I/MDM2/MIRLET7F1/MIR181B1/MIR200B/MIR30C2/SLC45A3/CCND2/BAK1/MIR28/SIRT1/RECK/MIR30E/PLCG1/SHC1/MIR7-2/CDC25B/GRB2/MIR29B2/MIR106B/SOX4/KRAS/EFNA3/SOS2/APC2/MIR27B/THBS1/TP63/TP53/BMF/MIR16-2/MIR26A2/ST14/ERBB2/ITGA5/MIR19B2/PDCD4/CASP3/MIR205/MIR192/BMPR2/HDAC1/STMN1/TPM1/CCNE2/MIR122/CCND1/HMOX1/CDKN1A/MIR101-1/MIR92A2/MIR128-2/SERPINB5/E2F2/PRKCB/RDX/CCNE1/MIR128-1/MIR27A/CDKN2A/PLCG2/EZH2/DNMT3B/NRAS/EFNA2/BCL2/MIR34A/PLAU/PIK3R3/MDM4/MIR103A2/ABCB1/MIR25/MIR141/IGF2BP1/RASSF1/SOS1/MIR10A/MCL1/MIR96/MIRLET7G/MIR146A/MIR23A/ZEB2/NOTCH2/MIR200A/MIR200C/MAPK1/PDGFB/IRS1/MIR331/GLS2/MIR214/NOTCH1/PTEN/MTOR/MAPK3/MIR181C/MIR215	102
KEGG	hsa04730	Long-term depression	17/2990	60/8135	0.9345	1	0.9392	GNAI2/IGF1/PLCB2/KRAS/PPP1R17/GNAQ/ARAF/BRAF/PLA2G4C/PLA2G4D/PRKCB/NRAS/MAPK1/NOS1/MAPK3/LYN/ITPR1	17
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/2990	14/8135	0.9348	1	0.9392	CHST2/B3GNT2/ST3GAL3	3
KEGG	hsa04611	Platelet activation	38/2990	124/8135	0.9368	1	0.9392	AKT2/RAP1A/GNAI2/MYL12B/ADCY7/ORAI1/PLCB2/ARHGEF1/PPP1R12A/RAP1B/NOS3/FYN/GNAQ/PIK3R6/PPP1CB/AKT1/PLA2G4C/PLA2G4D/PIK3R5/PLCG2/LCP2/ACTB/MAPK12/SNAP23/PIK3R3/COL1A2/ADCY4/PRKACG/MAPK1/ROCK2/MAPK11/BTK/COL1A1/ARHGEF12/MAPK3/LYN/VASP/ITPR1	38
KEGG	hsa03018	RNA degradation	23/2990	79/8135	0.9394	1	0.9392	EXOSC2/EDC3/PABPC3/TOB2/LSM5/EDC4/LSM3/PAN2/CNOT3/EXOSC5/DIS3L/PABPC1/TOB1/HSPD1/PABPC1L2A/EXOSC8/ENO1/SKIV2L/PNPT1/DCPS/EXOSC7/PABPC1L/PNLDC1	23
KEGG	hsa00230	Purine metabolism	39/2990	128/8135	0.9444	1	0.9392	NPR2/ITPA/PPAT/ENTPD4/AK5/FHIT/ADCY7/ENPP3/PDE8B/PDE4D/GMPR2/LACC1/NTPCR/NUDT9/CANT1/PFAS/PDE6D/NT5C1A/PDE8A/AK4/AMPD2/PDE7B/PGM1/ENTPD5/ADCY4/APRT/PGM2/NUDT2/RRM2/ENTPD1/ATIC/ADA/GUK1/GMPS/AK2/DCK/ENPP1/NT5DC4/PDE4C	39
KEGG	hsa04727	GABAergic synapse	26/2990	89/8135	0.9466	1	0.9392	GNAI2/ADCY7/GABRB3/SLC6A11/SLC6A12/GABRP/GABRD/GNG7/GNG5/GABARAPL2/GABBR1/GNB1/GABARAP/PRKCB/GABARAPL1/GPHN/GNG11/ADCY4/GABRA2/PRKACG/GABRA3/CACNA1F/GLS2/SLC38A5/GNGT1/CACNA1C	26
KEGG	hsa04744	Phototransduction	7/2990	29/8135	0.9498	1	0.9392	CALML5/CNGB1/GNAT2/RCVRN/GNB1/CALM1/GNGT1	7
KEGG	hsa04672	Intestinal immune network for IgA production	13/2990	49/8135	0.9522	1	0.9392	MAP3K14/IL10/TNFRSF17/IL4/CD28/CD40/HLA-DRA/TNFSF13/LTBR/HLA-DMB/ITGB7/IL15/IL2	13
KEGG	hsa00790	Folate biosynthesis	6/2990	26/8135	0.9553	1	0.9392	AKR1C3/CBR1/MOCS1/FPGS/GPHN/AKR1B1	6
KEGG	hsa05202	Transcriptional misregulation in cancer	60/2990	193/8135	0.9593	1	0.9392	FEV/FUS/MEN1/IL2RB/MDM2/CDK9/SP1/SLC45A3/SIX4/CCND2/HHEX/BAK1/IGF1/ID2/PRCC/DEFA6/PML/DUSP6/RARA/PBX3/POLK/GADD45A/TRAF1/TP53/CSF1R/DEFA5/CCNT2/SS18L1/HDAC1/HOXA9/CDKN2C/CDKN1A/DDX5/RELA/BIRC2/CD40/LDB1/FLT3/RXRB/JUP/KLF3/PLAU/BCL11B/RUNX2/PTK2/ETV4/PER2/ZBTB17/GZMB/IGFBP3/ITGB7/ARNT2/HPGD/CCNA1/MYCN/NGFR/ETV7/CEBPA/GADD45G/FLI1	60
KEGG	hsa04713	Circadian entrainment	28/2990	97/8135	0.9599	1	0.9392	GNAI2/ADCY7/FOS/PLCB2/CALML5/GNAQ/GNG7/GNG5/GNB1/CACNA1I/PRKCB/NOS1AP/CAMK2A/GNG11/ADCY4/CREB1/MTNR1B/CACNA1G/PRKACG/CALM1/PER2/MAPK1/CAMK2D/NOS1/GNGT1/CACNA1C/MAPK3/ITPR1	28
KEGG	hsa04360	Axon guidance	56/2990	182/8135	0.9631	1	0.9392	PLXNA4/RYK/GNAI2/SEMA4C/MYL12B/NTN1/EPHA2/SEMA3A/PLCG1/PDPK1/EFNB3/GSK3B/EPHB6/FYN/KRAS/EFNA3/CFL1/PLXNB2/PPP3CB/PPP3R1/SEMA5A/SEMA4F/BMPR2/NCK2/WNT4/RGS3/PLXNA1/PPP3CA/NTN4/ABLIM2/PLCG2/SRGAP3/EPHB1/NRAS/EFNA2/CAMK2A/SEMA4D/ABLIM1/TRPC3/PIK3R3/RRAS/PTK2/ABLIM3/EPHA4/MAPK1/CAMK2D/ROCK2/NEO1/EPHA7/GDF7/EPHA3/ARHGEF12/BMP7/MAPK3/LRIG2/NTN3	56
KEGG	hsa04024	cAMP signaling pathway	69/2990	221/8135	0.9653	1	0.9392	AKT2/RAP1A/GNAI2/PTGER2/BAD/VAV1/PLN/ADCY7/FOS/ORAI1/RRAS2/ACOX3/NFATC1/PPP1R12A/PLD2/TNNI3/PDE4D/CALML5/RAP1B/TIAM1/GPHB5/ATP1A4/SST/JUN/CNGB1/PPP1CB/GABBR1/AKT1/BRAF/ADRB2/TSHR/OXTR/RELA/SSTR2/ATP2B3/SLC9A1/CREB3L1/ATP1B2/ATP2B2/HTR1E/LHB/CAMK2A/ATP1A1/PIK3R3/RRAS/HCN4/FXYD1/ADCY4/ABCC4/CREB1/SUCNR1/ADORA2A/PLCE1/PRKACG/CALM1/PPP1R1B/MAPK1/CAMK2D/CACNA1F/ROCK2/MAPK10/FSHB/POMC/CACNA1C/MAPK3/ARAP3/CREB3L4/PDE4C/MC2R	69
KEGG	hsa04913	Ovarian steroidogenesis	13/2990	51/8135	0.9685	1	0.9392	AKR1C3/ADCY7/IGF1/INS/PLA2G4C/PLA2G4D/LHB/HSD17B1/BMP15/ADCY4/PRKACG/FSHB/SCARB1	13
KEGG	hsa00410	beta-Alanine metabolism	7/2990	31/8135	0.9702	1	0.9392	CSAD/ACOX3/MLYCD/EHHADH/AOC2/HADHA/ECHS1	7
KEGG	hsa04726	Serotonergic synapse	33/2990	115/8135	0.9732	1	0.9392	GNAI2/PLCB2/GABRB3/KRAS/CYP2C9/GNAQ/GNG7/GNG5/ARAF/HTR3C/CASP3/BRAF/PLA2G4C/PLA2G4D/GNB1/CYP2C19/PRKCB/DUSP1/MAOA/HTR1E/NRAS/GNG11/SLC18A1/CYP2C18/PRKACG/CYP2C8/MAPK1/CACNA1F/HTR2A/GNGT1/CACNA1C/MAPK3/ITPR1	33
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	18/2990	69/8135	0.9779	1	0.9392	CBR1/MGST3/GSTA4/CYP2C9/SULT2A1/GSTK1/NAT1/CYP3A43/MGST1/GSTA2/CYP2C19/UGT2B11/CYP2C18/CYP2C8/CYP2E1/GSTA5/CYP3A4/GSTM1	18
KEGG	hsa00512	Mucin type O-glycan biosynthesis	8/2990	36/8135	0.9799	1	0.9392	GCNT4/POC1B-GALNT4/GALNT6/GALNT12/GALNT11/GALNT5/ST6GALNAC3/GALNT15	8
KEGG	hsa00860	Porphyrin metabolism	10/2990	43/8135	0.9803	1	0.9392	COX15/BLVRA/FECH/HMOX1/COX10/UGT2B11/PPOX/ALAS1/CPOX/BLVRB	10
KEGG	hsa04976	Bile secretion	24/2990	89/8135	0.981	1	0.9392	HMGCR/ADCY7/ABCC2/SULT2A1/SLC4A5/ATP1A4/SLC10A1/SLC9A1/ATP1B2/UGT2B11/ATP1A1/ABCB1/ADCY4/ABCC4/SLC4A4/ABCG2/PRKACG/SLCO1B3/SLC4A2/SLC10A2/CYP3A4/SCARB1/SLCO1B1/SLC27A5	24
KEGG	hsa04742	Taste transduction	23/2990	86/8135	0.9816	1	0.9392	TAS2R4/TAS2R5/TAS2R3/PLCB2/CHRM3/TAS2R13/TAS2R20/HTR3C/GABBR1/TAS2R41/TAS2R50/PKD1L3/HTR1E/HCN4/ADCY4/GABRA2/PRKACG/GABRA3/TAS2R43/TAS2R14/CACNA1C/GRM4/P2RY4	23
KEGG	hsa05032	Morphine addiction	24/2990	91/8135	0.9868	1	0.9392	GNAI2/ADCY7/GABRB3/PDE8B/PDE4D/GABRP/GABRD/GNG7/GNG5/GABBR1/ARRB1/PDE8A/GNB1/PRKCB/GNG11/PDE7B/ADCY4/GABRA2/ARRB2/PRKACG/GABRA3/GRK5/GNGT1/PDE4C	24
KEGG	hsa00040	Pentose and glucuronate interconversions	7/2990	34/8135	0.9869	1	0.9392	UGP2/AKR1A1/UGT2B11/DCXR/DHDH/KL/AKR1B1	7
KEGG	hsa00982	Drug metabolism - cytochrome P450	18/2990	72/8135	0.988	1	0.9392	FMO4/MGST3/GSTA4/CYP2C9/FMO3/GSTK1/MGST1/GSTA2/CYP2C19/MAOA/UGT2B11/ADH1A/CYP2C8/CYP2E1/GSTA5/CYP3A4/GSTM1/ADH4	18
KEGG	hsa04724	Glutamatergic synapse	31/2990	114/8135	0.9885	1	0.9392	GNAI2/ADCY7/PLCB2/PLD2/HOMER2/SLC1A6/GNAQ/PPP3CB/GNG7/GNG5/PPP3R1/PLA2G4C/PLA2G4D/GNB1/HOMER3/PPP3CA/GRIK1/SLC1A2/PRKCB/SHANK3/GNG11/GRM6/ADCY4/PRKACG/MAPK1/GLS2/GNGT1/CACNA1C/MAPK3/GRM4/ITPR1	31
KEGG	hsa04145	Phagosome	43/2990	152/8135	0.9895	1	0.9392	RAB7A/TUBA3C/HGS/TCIRG1/C3/TFRC/ATP6V1C2/FCGR3A/DYNC1H1/ITGAV/THBS1/STX12/ATP6V1B1/ITGA5/TUBA3E/DYNC1I1/RAB5C/ATP6V0E2/CALR/TAP1/RILP/ATP6V1G3/TUBB3/ATP6AP1/SEC61A1/ACTB/HLA-DRA/ATP6V0B/CTSL/HLA-DMB/ITGB2/TUBB2A/ATP6V1A/TAP2/HLA-C/CORO1A/SEC61G/CYBB/NOS1/TUBB/RAB5A/MSR1/SCARB1	43
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	16/2990	66/8135	0.9895	1	0.9392	HARS2/LARS2/YARS2/CARS2/AARS2/MARS2/TARS2/DARS2/FARSA/SARS2/NARS2/RARS2/PARS2/VARS2/GATC/MTFMT	16
KEGG	hsa04923	Regulation of lipolysis in adipocytes	13/2990	56/8135	0.9898	1	0.9392	AKT2/GNAI2/ADCY7/INS/AKT1/ADRB2/TSHR/PIK3R3/ADCY4/PNPLA2/PRKACG/ADRB3/IRS1	13
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	19/2990	78/8135	0.9932	1	0.9392	CBR1/MGST3/AKR7A3/GSTA4/CYP2C9/SULT2A1/GSTK1/AKR7A2/MGST1/GSTA2/UGT2B11/ADH1A/CYP2E1/DHDH/GSTA5/CYP3A4/CBR3/GSTM1/ADH4	19
KEGG	hsa04392	Hippo signaling pathway - multiple species	5/2990	29/8135	0.994	1	0.9392	FAT4/MOB1A/TEAD2/RASSF1/WTIP	5
KEGG	hsa00983	Drug metabolism - other enzymes	19/2990	80/8135	0.9956	1	0.9392	UMPS/ITPA/CES2/MGST3/TK2/GSTA4/NAT1/MGST1/GSTA2/UGT2B11/TK1/RRM2/CMPK1/GMPS/CYP2E1/GSTA5/CES1/CYP3A4/GSTM1	19
KEGG	hsa00340	Histidine metabolism	3/2990	22/8135	0.9962	1	0.9392	HDC/MAOA/FTCD	3
KEGG	hsa05323	Rheumatoid arthritis	22/2990	93/8135	0.9977	1	0.9392	IL23A/TNF/CSF1/TCIRG1/FOS/ATP6V1C2/ATP6V1B1/JUN/CD28/ATP6V0E2/ATP6V1G3/ATP6AP1/HLA-DRA/ATP6V0B/TNFSF13/CTSL/HLA-DMB/ITGB2/ATP6V1A/ITGAL/IL15/IL17A	22
KEGG	hsa05033	Nicotine addiction	7/2990	40/8135	0.9978	1	0.9392	GABRB3/GABRP/GABRD/CHRNA7/GABRA2/GABRA3/CHRNB2	7
KEGG	hsa00531	Glycosaminoglycan degradation	2/2990	19/8135	0.998	1	0.9392	IDUA/SGSH	2
KEGG	hsa00830	Retinol metabolism	14/2990	68/8135	0.9988	1	0.9392	DHRS4L2/RDH11/CYP2C9/RETSAT/RDH12/PNPLA4/UGT2B11/ADH1A/SDR16C5/CYP2C18/RDH5/CYP2C8/CYP3A4/ADH4	14
KEGG	hsa04740	Olfactory transduction	132/2990	440/8135	0.9991	1	0.9392	OR2T34/OR2T11/OR56A3/OR2AE1/OR4D1/OR10K2/OR52K1/OR2AG1/OR5B21/OR2L3/OR8G5/OR10H2/OR2L5/OR8H3/OR51J1/OR5W2/CALML5/OR2L8/OR51M1/OR10G4/OR52H1/OR8D1/OR4F6/OR56B4/OR2A2/OR5D13/GNG7/OR13G1/OR2D3/OR5B3/GNAL/OR51A4/OR4D10/OR2M5/OR4N5/OR6A2/CNGB1/OR6C74/OR7G2/OR4P4/OR7G1/OR10X1/ARRB1/OR2AK2/OR4K13/OR1E1/OR5B12/OR8B12/OR11H1/OR10J1/OR51B4/GNB1/OR1L3/OR1B1/OR2T29/OR51B6/OR52I2/OR2T10/OR4D5/OR52J3/OR52E6/OR2B3/OR2T4/OR4K3/OR10H1/OR52B4/OR10H4/OR5D14/OR2G6/OR4C3/OR52D1/OR1L1/OR10S1/OR2W1/OR10A5/OR4X2/OR6C2/CAMK2A/OR5AR1/OR1K1/OR52L1/OR2A42/OR52E8/OR2L2/OR52K2/OR1N1/OR52N5/OR6C1/OR2W3/OR10W1/OR5I1/SLC24A4/OR4Q3/ARRB2/OR8A1/PRKACG/OR4S2/CALM1/OR6N1/OR11L1/OR1I1/OR5R1/OR6C65/CAMK2D/OR13A1/OR2M2/OR8B3/OR11H4/OR7A5/OR6J1/OR2T35/OR6Q1/OR2T8/OR7G3/OR4C15/OR13C8/OR5K3/OR6C70/OR51B5/OR4C6/OR8K1/OR56A1/OR52W1/OR5L1/OR5M9/OR2M4/OR2Z1/OR8K5/OR56A5/OR2T1/OR3A1/OR1D2	132
KEGG	hsa04610	Complement and coagulation cascades	18/2990	85/8135	0.9994	1	0.9392	VSIG4/KLKB1/C3/A2M/F3/CD59/CD55/SERPINC1/PLAU/BDKRB2/ITGB2/CFHR1/C8G/CFHR4/CR1L/C1QC/CR2/C1QA	18
KEGG	hsa00910	Nitrogen metabolism	1/2990	17/8135	0.9996	1	0.9392	CA5B	1
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/2990	30/8135	0.9998	1	0.9392	AKR1A1/UGT2B11/KL	3
KEGG	hsa04514	Cell adhesion molecules	34/2990	149/8135	0.9999	1	0.9392	SELPLG/NCAM1/SPN/SIGLEC1/ITGB8/TIGIT/CLDN15/CDH4/ITGAV/PECAM1/CD28/CD99L2/SDC1/CDH1/CLDN10/CD40/PTPRF/CNTNAP2/CLDN14/HLA-DRA/GLG1/HLA-DMB/CD8B/ITGB2/ICAM3/HLA-C/NRCAM/NEO1/ITGB7/ITGAL/ICAM2/NRXN3/PDCD1LG2/CLDN16	34
KEGG	hsa00140	Steroid hormone biosynthesis	9/2990	61/8135	1	1	0.9392	AKR1C3/HSD17B12/SRD5A3/UGT2B11/HSD17B1/CYP2E1/CYP11B2/CYP3A4/CYP21A2	9
KEGG	hsa05150	Staphylococcus aureus infection	18/2990	96/8135	1	1	0.9392	SELPLG/C3/KRT9/IL10/DEFA6/FCGR3A/DEFA5/KRT34/HLA-DRA/HLA-DMB/DEFB1/ITGB2/KRT14/KRT16/ITGAL/C1QC/KRT25/C1QA	18
KEGG	hsa04080	Neuroactive ligand-receptor interaction	93/2990	353/8135	1	1	0.9392	NPFF/P2RX7/TAC4/PTGER2/PTGER4/PYY/INSL3/CHRNA10/KISS1/RLN2/C3/AGTR1/HRH4/GABRB3/CHRM3/MLN/LTB4R2/LEP/GABRP/GABRD/GPHB5/CHRNE/UCN/HRH1/ADRA2B/S1PR1/SST/PTGDR/GCGR/CHRNA7/NPY5R/GABBR1/ADRA2A/S1PR5/AGTR2/NTS/GLRA3/CNR2/ADRB2/TSHR/OXTR/VIPR1/PPY/ADRA1D/LPAR2/SSTR2/GRIK1/TAAR2/P2RY11/CYSLTR2/NMUR1/PTGER1/HTR1E/TAAR1/LHB/GRPR/P2RY14/CHRNA5/CYSLTR1/BDKRB2/GRM6/CHRNB4/GPR50/TRH/HRH3/GHRH/F2RL1/MTNR1B/ADORA2A/MCHR2/HCRTR2/GABRA2/CHRM5/RXFP1/GABRA3/PRSS1/ADRB3/HTR2A/CHRNB2/FSHB/CHRNA3/POMC/MLNR/NTSR2/MC3R/CHRNB1/AVP/PRLR/GZMA/AGT/GRM4/P2RY4/MC2R	93
KEGG	hsa05034	Alcoholism	40/2990	187/8135	1	1	0.9392	GNAI2/SLC29A3/ATF6B/SHC1/HDAC7/HDAC8/CALML5/GRB2/KRAS/SOS2/FOSB/GNG7/GNG5/ARAF/PPP1CB/HDAC1/BRAF/SLC29A2/GNB1/HDAC11/CREB3L1/MAOA/HDAC3/NRAS/GNG11/HDAC10/CREB1/ADORA2A/SOS1/SLC18A1/PRKACG/CALM1/PPP1R1B/MAPK1/NTRK2/GNGT1/MAPK3/ATF2/CREB3L4/ATF4	40
KEGG	hsa04613	Neutrophil extracellular trap formation	34/2990	190/8135	1	1	0.9392	AKT2/SLC25A4/SELPLG/HMGB1/C3/PLCG1/PLCB2/HDAC7/HDAC8/FCGR3A/AGER/SIGLEC9/AKT1/HDAC1/HDAC11/RELA/PRKCB/PLCG2/HDAC3/ACTB/MAPK12/VDAC2/HDAC10/PIK3R3/ITGB2/MAPK1/MAPK11/CR1L/CLCN5/CYBB/ITGAL/MTOR/GSDMD/MAPK3	34
KEGG	hsa05322	Systemic lupus erythematosus	16/2990	136/8135	1	1	0.9392	TNF/C3/IL10/TRIM21/FCGR3A/SNRPD3/CD28/ACTN1/CD40/HLA-DRA/HLA-DMB/SNRPB/C8G/SNRPD1/C1QC/C1QA	16