ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa04142 Lysosome 26/525 132/8135 2.334e-07 7.421e-05 6.264e-05 MANBA/DMXL2/GLB1/GNS/ARSB/ASAH1/ATP6V0B/GLA/CTNS/GBA/CTSA/CD68/CLTA/FUCA2/PLA2G15/SORT1/CLTC/GM2A/NAGA/ATP6V0A1/CTSB/CTSS/PSAP/ATP6V0D1/SLC11A1/LAMP2 26 KEGG hsa04625 C-type lectin receptor signaling pathway 22/525 104/8135 5.546e-07 8.819e-05 7.444e-05 FCER1G/CALML4/PIK3R1/PIK3CB/BCL10/CLEC4E/RRAS2/PAK1/PRKCD/CLEC7A/PPP3R1/RRAS/SYK/CLEC4D/MAPK11/NFKB1/PLK3/ITPR2/NFATC3/NLRP3/MRAS/MDM2 22 KEGG hsa05152 Tuberculosis 30/525 180/8135 1.238e-06 0.0001313 0.0001108 FCER1G/RAB7A/CALML4/C3/CD14/ATP6V0B/CR1L/BCL10/TLR9/TLR2/IFNGR1/CLEC4E/CLEC7A/HSPD1/PPP3R1/SYK/RAB5B/MRC1/ATP6V0A1/IFNGR2/MAPK11/NFKB1/ITGAM/IL10RB/CR1/CTSS/PLK3/VDR/ATP6V0D1/LAMP2 30 KEGG hsa05134 Legionellosis 14/525 57/8135 1.064e-05 0.0008457 0.0007138 HSPA1A/C3/CD14/CR1L/NLRC4/TLR2/HSPA2/TLR5/HSPD1/NAIP/NFKB1/ITGAM/CR1/ARF1 14 KEGG hsa04145 Phagosome 24/525 152/8135 3.639e-05 0.002063 0.001741 CD36/ATP6V1B2/RAB7A/CYBB/ATP6V1G2/C3/CD14/ATP6V0B/FCAR/TLR2/NCF2/ATP6V1A/CLEC7A/DYNC1LI2/RAB5B/MRC1/TUBA1A/ATP6V0A1/TUBA4A/ATP6V1D/ITGAM/CTSS/ATP6V0D1/LAMP2 24 KEGG hsa04216 Ferroptosis 11/525 41/8135 3.893e-05 0.002063 0.001741 ATG7/CYBB/MAP1LC3B/LPCAT3/SAT2/SLC3A2/ACSL3/NCOA4/FTL/ACSL1/SAT1 11 KEGG hsa04662 B cell receptor signaling pathway 16/525 82/8135 5.602e-05 0.002545 0.002148 PIK3R1/DAPP1/PIK3CB/LILRA3/BCL10/LILRA2/LILRB4/GSK3B/PPP3R1/SYK/FOS/NFKB1/LILRA1/CD79A/BLNK/NFATC3 16 KEGG hsa05132 Salmonella infection 32/525 249/8135 0.0001316 0.00523 0.004415 TNFRSF10B/RAB7A/PIK3CB/CD14/CYFIP1/S100A10/ELMO2/NLRC4/TLR9/TLR2/PAK1/TLR5/RRAS/EXOC2/NAIP/ANXA2/DYNC1LI2/FOS/RAB5B/STX10/TUBA1A/BRK1/ACTR1A/TUBA4A/MAPK11/NFKB1/LY96/ARHGEF26/NLRP3/MLKL/PIK3C2B/ARF1 32 KEGG hsa04380 Osteoclast differentiation 20/525 128/8135 0.0001858 0.006566 0.005542 PIK3R1/PIK3CB/LILRA3/SIRPA/LILRA2/IFNGR1/LILRB4/NCF2/PPP3R1/SYK/FOS/TYK2/SQSTM1/IFNGR2/MAPK11/NFKB1/LILRA1/BLNK/PPARG/SPI1 20 KEGG hsa05144 Malaria 11/525 50/8135 0.0002708 0.008611 0.007268 PECAM1/CD36/CR1L/TLR9/TLR2/ICAM1/CSF3/HGF/CR1/LRP1/SELE 11 KEGG hsa01200 Carbon metabolism 18/525 115/8135 0.000377 0.01069 0.009023 IDNK/PGD/TKT/HK3/ACSS2/G6PD/FBP1/IDH1/PKM/PGK1/PGAM4/ACOX1/TALDO1/PGK2/ALDOA/CAT/GCK/SDHC 18 KEGG hsa04721 Synaptic vesicle cycle 14/525 78/8135 0.0004034 0.01069 0.009023 ATP6V1B2/ATP6V1G2/ATP6V0B/NSF/SLC18A3/SLC6A5/CLTA/ATP6V1A/CLTC/ATP6V0A1/ATP6V1D/SLC6A13/SLC17A7/ATP6V0D1 14 KEGG hsa05131 Shigellosis 29/525 247/8135 0.001196 0.02927 0.0247 CAPN2/PIK3R1/C3/PIK3CB/CD14/MAP1LC3B/ELMO2/NLRC4/RRAGC/BCL10/CD44/TNIP1/HK3/FOXO1/PRKCD/GSK3B/TLR5/CALCOCO2/NAIP/WASF1/ATM/SQSTM1/ILK/MAPK11/NFKB1/ITPR2/NLRP3/MDM2/ARF1 29 KEGG hsa00071 Fatty acid degradation 9/525 43/8135 0.001415 0.03215 0.02714 CPT1A/HADHB/ALDH2/ACSL3/ACSBG2/ACAA1/ACOX1/ACSL1/ACADVL 9 KEGG hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 14/525 89/8135 0.001564 0.03316 0.02799 PIK3R1/PIK3CB/TLR9/TLR2/IFNGR1/PPP3R1/FOS/RASGRP1/IFNGR2/MAPK11/NFKB1/MAP3K3/NFATC3/EML4 14 KEGG hsa04218 Cellular senescence 20/525 156/8135 0.002404 0.04631 0.03909 HIPK3/CALML4/CAPN2/PIK3R1/PIK3CB/FOXO1/RRAS2/IGFBP3/PPP3R1/RRAS/ATM/SQSTM1/PPP1CA/MAPK11/NFKB1/ITPR2/NFATC3/MRAS/E2F5/MDM2 20 KEGG hsa00030 Pentose phosphate pathway 7/525 30/8135 0.002476 0.04631 0.03909 IDNK/PGD/TKT/G6PD/FBP1/TALDO1/ALDOA 7 KEGG hsa05202 Transcriptional misregulation in cancer 23/525 193/8135 0.003085 0.05299 0.04472 WNT16/DUSP6/BMP2K/CD14/ETV6/FOXO1/PDGFA/CD86/IGFBP3/POLK/TCF3/ATM/BCL2A1/TFE3/NFKB1/NFKBIZ/ITGAM/ELK4/PPARG/ITGB7/IL2RB/MDM2/SPI1 23 KEGG hsa01212 Fatty acid metabolism 10/525 57/8135 0.003166 0.05299 0.04472 CPT1A/ELOVL1/HADHB/ACSL3/ACSBG2/ACAA1/ACOX1/ACSL1/ACADVL/FASN 10 KEGG hsa05140 Leishmaniasis 12/525 77/8135 0.003583 0.05696 0.04808 CYBB/C3/CR1L/TLR2/IFNGR1/NCF2/FOS/IFNGR2/MAPK11/NFKB1/ITGAM/CR1 12 KEGG hsa05110 Vibrio cholerae infection 9/525 50/8135 0.004206 0.06369 0.05376 ATP6V1B2/ATP6V1G2/ATP6V0B/ATP6V1A/SLC12A2/ATP6V0A1/ATP6V1D/ATP6V0D1/ARF1 9 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 11/525 70/8135 0.00487 0.07039 0.05941 ATP6V1B2/ATP6V1G2/ATP6V0B/ADAM17/PAK1/ATP6V1A/ATP6V0A1/MAPK11/NFKB1/ATP6V1D/ATP6V0D1 11 KEGG hsa00600 Sphingolipid metabolism 9/525 52/8135 0.005508 0.07615 0.06428 GLB1/ASAH1/SGMS2/GLA/GBA/SGMS1/ACER3/SPTLC2/PSAP 9 KEGG hsa04966 Collecting duct acid secretion 6/525 27/8135 0.006478 0.08584 0.07246 ATP6V1B2/ATP6V1G2/ATP6V1A/ATP6V0A1/ATP6V1D/ATP6V0D1 6 KEGG hsa00500 Starch and sucrose metabolism 7/525 36/8135 0.007258 0.09232 0.07793 SI/HK3/AMY2A/PYGL/GYG1/ENPP1/GCK 7 KEGG hsa05418 Fluid shear stress and atherosclerosis 17/525 139/8135 0.007922 0.0969 0.08179 PECAM1/CALML4/PIK3R1/PIK3CB/MGST1/PDGFA/GSTA2/NCF2/ICAM1/SUMO1/FOS/SQSTM1/MAPK11/SDC4/NFKB1/SELE/ITGA2B 17 KEGG hsa03320 PPAR signaling pathway 11/525 75/8135 0.008246 0.09712 0.08198 CD36/CPT1A/CYP27A1/ACSL3/ACSBG2/ACAA1/ACOX1/ILK/ACSL1/PPARG/GK 11 KEGG hsa04140 Autophagy - animal 17/525 141/8135 0.009104 0.1022 0.08626 ATG7/RAB7A/PIK3R1/PIK3CB/MAP1LC3B/DAPK1/RRAGC/RRAS2/PRKCD/RRAS/SQSTM1/CTSB/WDR41/MTMR14/MTMR3/MRAS/LAMP2 17 KEGG hsa04931 Insulin resistance 14/525 108/8135 0.009319 0.1022 0.08626 CD36/PIK3R1/CPT1A/SLC2A1/PIK3CB/CREB3L4/MLX/FOXO1/PRKCD/GSK3B/PYGL/RPS6KA1/PPP1CA/NFKB1 14 KEGG hsa04066 HIF-1 signaling pathway 14/525 109/8135 0.01008 0.1041 0.08789 TIMP1/CYBB/PIK3R1/SLC2A1/PIK3CB/IFNGR1/HK3/ARNT/PGK1/LTBR/PGK2/IFNGR2/NFKB1/ALDOA 14 KEGG hsa00010 Glycolysis / Gluconeogenesis 10/525 67/8135 0.01021 0.1041 0.08789 HK3/ACSS2/ALDH2/FBP1/PKM/PGK1/PGAM4/PGK2/ALDOA/GCK 10 KEGG hsa04613 Neutrophil extracellular trap formation 21/525 190/8135 0.0107 0.1041 0.08789 ATG7/TLR8/CYBB/PIK3R1/C3/PIK3CB/AQP9/CR1L/TLR2/FPR1/HDAC5/NCF2/CLEC7A/SYK/FPR2/MAPK11/NFKB1/ITGAM/CR1/PPIF/ITGA2B 21 KEGG hsa04640 Hematopoietic cell lineage 13/525 99/8135 0.01081 0.1041 0.08789 CD36/CD14/CR1L/CD1A/ANPEP/CD44/CSF3/CSF2RA/ITGAM/CD5/CR1/CD33/ITGA2B 13 KEGG hsa05417 Lipid and atherosclerosis 23/525 215/8135 0.01133 0.106 0.08948 HSPA1A/TNFRSF10B/CD36/CALML4/CYBB/PIK3R1/PIK3CB/CD14/TLR2/NCF2/ICAM1/GSK3B/HSPA2/HSPD1/PPP3R1/FOS/MAPK11/NFKB1/LY96/NFATC3/SELE/PPARG/NLRP3 23 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 8/525 49/8135 0.01231 0.1119 0.09441 NPL/HK3/CYB5R4/CYB5R1/GNPDA2/GCK/FPGT/NAGK 8 KEGG hsa05167 Kaposi sarcoma-associated herpesvirus infection 21/525 194/8135 0.01336 0.118 0.09961 CALML4/PIK3R1/C3/PIK3CB/MAP1LC3B/HCK/GNG3/IFNGR1/CD86/ICAM1/GSK3B/PPP3R1/SYK/FOS/TYK2/MAPK11/NFKB1/GNB2/CCR1/ITPR2/NFATC3 21 KEGG hsa05230 Central carbon metabolism in cancer 10/525 70/8135 0.01375 0.1182 0.09979 PIK3R1/SLC2A1/PIK3CB/HK3/G6PD/IDH1/PKM/PGAM4/FGFR2/GCK 10 KEGG hsa04658 Th1 and Th2 cell differentiation 12/525 92/8135 0.01475 0.1234 0.1042 IFNGR1/STAT4/PPP3R1/FOS/TYK2/RUNX3/IFNGR2/MAPK11/MAML3/NFKB1/NFATC3/IL2RB 12 KEGG hsa04620 Toll-like receptor signaling pathway 13/525 104/8135 0.01596 0.1301 0.1098 TLR8/PIK3R1/PIK3CB/CD14/CXCL11/TLR9/TLR2/CD86/TLR5/FOS/MAPK11/NFKB1/LY96 13 KEGG hsa04137 Mitophagy - animal 10/525 72/8135 0.01658 0.1318 0.1113 RAB7A/MAP1LC3B/RRAS2/RHOT1/CALCOCO2/RRAS/TFE3/SQSTM1/PGAM5/MRAS 10 KEGG hsa00051 Fructose and mannose metabolism 6/525 33/8135 0.01747 0.1355 0.1144 HK3/PFKFB4/FBP1/SORD/ALDOA/FPGT 6 KEGG hsa04922 Glucagon signaling pathway 13/525 107/8135 0.01984 0.147 0.1241 CALML4/CPT1A/SLC2A1/CREB3L4/FOXO1/FBP1/PKM/PPP3R1/PGAM4/PYGL/PHKB/GCK/ITPR2 13 KEGG hsa00592 alpha-Linolenic acid metabolism 5/525 25/8135 0.01988 0.147 0.1241 PLA2G4A/ACAA1/ACOX1/PLA2G1B/PLB1 5 KEGG hsa04666 Fc gamma R-mediated phagocytosis 12/525 97/8135 0.02168 0.1567 0.1323 PLA2G4A/PIK3R1/PIK3CB/HCK/MARCKS/PAK1/PRKCD/ASAP1/SYK/WASF1/GSN/PLD2 12 KEGG hsa05133 Pertussis 10/525 76/8135 0.02349 0.1641 0.1385 CALML4/C3/CD14/FOS/MAPK11/NFKB1/ITGAM/LY96/NLRP3/GNAI3 10 KEGG hsa04360 Axon guidance 19/525 182/8135 0.02538 0.1641 0.1385 PIK3R1/PIK3CB/SEMA4F/CDK5/PLXNC1/DPYSL2/PAK1/EFNB2/GSK3B/SEMA4C/PPP3R1/RRAS/UNC5C/ILK/LRRC4C/ABLIM2/NFATC3/GNAI3/PLXNB2 19 KEGG hsa00061 Fatty acid biosynthesis 4/525 18/8135 0.02542 0.1641 0.1385 ACSL3/ACSBG2/ACSL1/FASN 4 KEGG hsa00511 Other glycan degradation 4/525 18/8135 0.02542 0.1641 0.1385 MANBA/GLB1/GBA/FUCA2 4 KEGG hsa05100 Bacterial invasion of epithelial cells 10/525 77/8135 0.0255 0.1641 0.1385 PIK3R1/PIK3CB/ELMO2/CTNNA1/CLTA/CLTC/WASF1/CBL/ILK/ARHGEF26 10 KEGG hsa04014 Ras signaling pathway 23/525 232/8135 0.0258 0.1641 0.1385 RASGRF1/PLA2G4A/CALML4/PIK3R1/PIK3CB/RIN1/TIAM1/GNG3/PDGFA/RRAS2/PAK1/RRAS/EXOC2/RAB5B/PLA2G1B/RASGRP1/HGF/NFKB1/FGFR2/GNB2/MRAS/RASGRP4/PLD2 23 KEGG hsa04930 Type II diabetes mellitus 7/525 46/8135 0.02675 0.1668 0.1408 PIK3R1/PIK3CB/HK3/PRKCD/PKM/ABCC8/GCK 7 KEGG hsa05145 Toxoplasmosis 13/525 112/8135 0.02782 0.1701 0.1436 HSPA1A/LAMA5/TLR2/IFNGR1/HSPA2/TYK2/IFNGR2/MAPK11/NFKB1/IL10RB/PPIF/LY96/GNAI3 13 KEGG hsa04210 Apoptosis 15/525 136/8135 0.02872 0.1723 0.1455 TNFRSF10B/CAPN2/PIK3R1/PIK3CB/LMNB2/MCL1/FOS/ATM/BCL2A1/TUBA1A/CTSB/TUBA4A/NFKB1/CTSS/ITPR2 15 KEGG hsa00531 Glycosaminoglycan degradation 4/525 19/8135 0.0306 0.178 0.1502 GLB1/GNS/ARSB/HPSE 4 KEGG hsa05142 Chagas disease 12/525 102/8135 0.03079 0.178 0.1502 PIK3R1/C3/PIK3CB/GNA15/TLR9/TLR2/IFNGR1/FOS/IFNGR2/MAPK11/NFKB1/GNAI3 12 KEGG hsa00480 Glutathione metabolism 8/525 58/8135 0.03162 0.1796 0.1516 PGD/ANPEP/MGST1/G6PD/GSTA2/IDH1/GGT6/CHAC2 8 KEGG hsa04064 NF-kappa B signaling pathway 12/525 104/8135 0.0351 0.1958 0.1653 EDA2R/CD14/BCL10/ICAM1/LTBR/SYK/ATM/BCL2A1/TNFRSF13C/NFKB1/BLNK/LY96 12 KEGG hsa05323 Rheumatoid arthritis 11/525 93/8135 0.03641 0.1996 0.1685 ATP6V1B2/ATP6V1G2/ATP6V0B/TLR2/CD86/ICAM1/ATP6V1A/FOS/ATP6V0A1/ATP6V1D/ATP6V0D1 11 KEGG hsa04010 MAPK signaling pathway 27/525 294/8135 0.03943 0.2089 0.1764 RASGRF1/PLA2G4A/HSPA1A/DUSP10/STK3/DUSP6/CD14/MAPKAPK3/PDGFA/RRAS2/PAK1/DUSP3/HSPA2/PPP3R1/RRAS/FOS/RASGRP1/RPS6KA1/HGF/MAPK11/NFKB1/MAP3K3/FGFR2/ELK4/NFATC3/MRAS/RASGRP4 27 KEGG hsa04936 Alcoholic liver disease 15/525 142/8135 0.04002 0.2089 0.1764 CPT1A/C3/C3AR1/CD14/FOXO1/ALDH2/GSK3B/ACOX1/MAPK11/NFKB1/CYP2E1/ACADVL/LY96/IL17RA/FASN 15 KEGG hsa04979 Cholesterol metabolism 7/525 50/8135 0.04008 0.2089 0.1764 CD36/APOC1/CYP27A1/NCEH1/SORT1/LRPAP1/LRP1 7 KEGG hsa00770 Pantothenate and CoA biosynthesis 4/525 21/8135 0.0427 0.219 0.1849 DPYD/ALDH2/VNN2/ENPP1 4 KEGG hsa00052 Galactose metabolism 5/525 31/8135 0.04636 0.234 0.1975 GLB1/SI/GLA/HK3/GCK 5 KEGG hsa04217 Necroptosis 16/525 159/8135 0.05053 0.2511 0.2119 PLA2G4A/TNFRSF10B/CYBB/CAPN2/CHMP2A/IFNGR1/STAT4/CHMP1B/TYK2/FTL/PYGL/SQSTM1/PGAM5/IFNGR2/NLRP3/MLKL 16 KEGG hsa04611 Platelet activation 13/525 124/8135 0.05614 0.2746 0.2318 PLA2G4A/FCER1G/PIK3R1/PIK3CB/SYK/RASGRP1/TBXAS1/PPP1CA/MAPK11/P2RX1/ITPR2/GNAI3/ITGA2B 13 KEGG hsa05146 Amoebiasis 11/525 102/8135 0.06373 0.3071 0.2592 RAB7A/PIK3R1/PIK3CB/CD14/LAMA5/GNA15/CD1A/TLR2/RAB5B/NFKB1/ITGAM 11 KEGG hsa05221 Acute myeloid leukemia 8/525 67/8135 0.06537 0.3103 0.2619 PIK3R1/DUSP6/PIK3CB/CD14/BCL2A1/NFKB1/ITGAM/SPI1 8 KEGG hsa05205 Proteoglycans in cancer 19/525 205/8135 0.06998 0.3247 0.2741 WNT16/PIK3R1/HPSE/PIK3CB/TIAM1/CD44/TLR2/RRAS2/PAK1/MIR21/RRAS/CBL/HGF/PPP1CA/MAPK11/SDC4/ITPR2/MRAS/MDM2 19 KEGG hsa04660 T cell receptor signaling pathway 11/525 104/8135 0.07124 0.3247 0.2741 PIK3R1/PIK3CB/BCL10/PAK1/GSK3B/PPP3R1/FOS/RASGRP1/MAPK11/NFKB1/NFATC3 11 KEGG hsa00983 Drug metabolism - other enzymes 9/525 80/8135 0.07148 0.3247 0.2741 TK2/MGST1/DPYD/GSTA2/CES1/CYP2E1/CDA/UGT2A2/IMPDH1 9 KEGG hsa04024 cAMP signaling pathway 20/525 221/8135 0.07785 0.3449 0.2911 GRIA2/CALML4/PIK3R1/PIK3CB/CREB3L4/TIAM1/CRHR2/RRAS2/PAK1/RRAS/FOS/ACOX1/PDE4C/PPP1CA/NFKB1/DRD5/AMH/GNAI3/GABBR2/PLD2 20 KEGG hsa05213 Endometrial cancer 7/525 58/8135 0.07809 0.3449 0.2911 PIK3R1/PIK3CB/CTNNA1/GSK3B/POLK/ILK/AXIN2 7 KEGG hsa04071 Sphingolipid signaling pathway 12/525 119/8135 0.08165 0.3509 0.2962 FCER1G/PIK3R1/PIK3CB/ASAH1/SGMS2/S1PR1/SGMS1/SPTLC2/MAPK11/NFKB1/GNAI3/PLD2 12 KEGG hsa04722 Neurotrophin signaling pathway 12/525 119/8135 0.08165 0.3509 0.2962 CALML4/PIK3R1/IRAK3/PIK3CB/YWHAE/SORT1/PRKCD/GSK3B/RPS6KA1/MAPK11/NFKB1/MAP3K3 12 KEGG hsa05208 Chemical carcinogenesis - reactive oxygen species 20/525 223/8135 0.08355 0.3543 0.299 PIK3R1/PIK3CB/MGST1/COX7B/GSTA2/NCF2/PRKCD/ARNT/PTPRJ/FOS/NDUFB4/HGF/MAPK11/NFKB1/CYP2E1/AHR/CAT/PPIF/SDHC/PLD2 20 KEGG hsa04659 Th17 cell differentiation 11/525 108/8135 0.08789 0.3678 0.3104 IFNGR1/PPP3R1/FOS/TYK2/IFNGR2/MAPK11/NFKB1/AHR/NFATC3/IRF4/IL2RB 11 KEGG hsa05030 Cocaine addiction 6/525 49/8135 0.09361 0.3807 0.3213 GRIA2/CREB3L4/DLG4/CDK5/NFKB1/GNAI3 6 KEGG hsa04070 Phosphatidylinositol signaling system 10/525 97/8135 0.09457 0.3807 0.3213 IMPA2/DGKG/CALML4/PIK3R1/PIK3CB/PI4K2B/MTMR14/ITPR2/MTMR3/PIK3C2B 10 KEGG hsa04610 Complement and coagulation cascades 9/525 85/8135 0.09619 0.3807 0.3213 SERPINA1/C3/C3AR1/CR1L/CLU/F5/ITGAM/CR1/F9 9 KEGG hsa00590 Arachidonic acid metabolism 7/525 61/8135 0.09639 0.3807 0.3213 PLA2G4A/LTA4H/ALOX12/PLA2G1B/TBXAS1/CYP2E1/PLB1 7 KEGG hsa00562 Inositol phosphate metabolism 8/525 73/8135 0.09696 0.3807 0.3213 IMPA2/PIK3CB/PI4K2B/PLCH2/INPP5J/MTMR14/MTMR3/PIK3C2B 8 KEGG hsa00564 Glycerophospholipid metabolism 10/525 98/8135 0.0996 0.3862 0.326 PLA2G4A/DGKG/GPD2/LPCAT3/MBOAT1/PLA2G15/PLA2G1B/CHAT/PLB1/PLD2 10 KEGG hsa04213 Longevity regulating pathway - multiple species 7/525 62/8135 0.103 0.3885 0.328 HSPA1A/PIK3R1/PIK3CB/EIF4EBP2/FOXO1/HSPA2/CAT 7 KEGG hsa04910 Insulin signaling pathway 13/525 137/8135 0.1039 0.3885 0.328 CALML4/PIK3R1/PIK3CB/HK3/FOXO1/GSK3B/FBP1/PYGL/CBL/PPP1CA/PHKB/GCK/FASN 13 KEGG hsa05135 Yersinia infection 13/525 137/8135 0.1039 0.3885 0.328 SKAP2/PIK3R1/PIK3CB/ELMO2/NLRC4/PTK2B/GSK3B/FOS/RPS6KA1/MAPK11/NFKB1/NFATC3/NLRP3 13 KEGG hsa01230 Biosynthesis of amino acids 8/525 75/8135 0.1091 0.4035 0.3406 TKT/IDH1/PKM/PGK1/PGAM4/TALDO1/PGK2/ALDOA 8 KEGG hsa04725 Cholinergic synapse 11/525 113/8135 0.1118 0.4086 0.3449 PIK3R1/PIK3CB/CREB3L4/GNG3/SLC18A3/FOS/KCNJ2/GNB2/CHAT/ITPR2/GNAI3 11 KEGG hsa00591 Linoleic acid metabolism 4/525 29/8135 0.1136 0.4106 0.3466 PLA2G4A/PLA2G1B/CYP2E1/PLB1 4 KEGG hsa04670 Leukocyte transendothelial migration 11/525 114/8135 0.117 0.4134 0.3489 PECAM1/CYBB/PIK3R1/PIK3CB/CTNNA1/PTK2B/NCF2/ICAM1/MAPK11/ITGAM/GNAI3 11 KEGG hsa04724 Glutamatergic synapse 11/525 114/8135 0.117 0.4134 0.3489 GRIA2/PLA2G4A/GNG3/DLG4/PPP3R1/GRIK1/GNB2/ITPR2/SLC17A7/GNAI3/PLD2 11 KEGG hsa05166 Human T-cell leukemia virus 1 infection 19/525 222/8135 0.1258 0.4394 0.3709 KAT2A/PIK3R1/SLC2A1/PIK3CB/CREB3L4/ICAM1/PPP3R1/LTBR/FOS/TCF3/ATM/TNFRSF13C/NFKB1/MAP3K3/ELK4/BUB1B/NFATC3/IL2RB/SPI1 19 KEGG hsa04144 Endocytosis 21/525 251/8135 0.1322 0.4569 0.3856 HSPA1A/RAB7A/PSD/CHMP2A/CLTA/EHD4/SPG21/RAB11FIP1/HSPA2/CHMP1B/ASAP1/CLTC/RAB5B/CBL/TSG101/FGFR2/SNF8/IL2RB/MDM2/ARF1/PLD2 21 KEGG hsa05170 Human immunodeficiency virus 1 infection 18/525 212/8135 0.1405 0.4805 0.4056 CALML4/RNF7/PIK3R1/PIK3CB/GNG3/PTK2B/TLR2/PAK1/PPP3R1/FOS/ATM/MAPK11/NFKB1/GNB2/ITPR2/NFATC3/GNAI3/APOBEC3D 18 KEGG hsa04728 Dopaminergic synapse 12/525 132/8135 0.144 0.4845 0.409 GRIA2/CALML4/CREB3L4/GNG3/GSK3B/FOS/PPP1CA/MAPK11/DRD5/GNB2/ITPR2/GNAI3 12 KEGG hsa04912 GnRH signaling pathway 9/525 93/8135 0.1447 0.4845 0.409 PLA2G4A/CALML4/PTK2B/GNRH1/PRKCD/MAPK11/MAP3K3/ITPR2/PLD2 9 KEGG hsa04920 Adipocytokine signaling pathway 7/525 69/8135 0.1555 0.5097 0.4302 CD36/CPT1A/SLC2A1/ACSL3/ACSBG2/NFKB1/ACSL1 7 KEGG hsa05211 Renal cell carcinoma 7/525 69/8135 0.1555 0.5097 0.4302 PIK3R1/SLC2A1/PIK3CB/PAK1/ARNT/TFE3/HGF 7 KEGG hsa04072 Phospholipase D signaling pathway 13/525 148/8135 0.1589 0.5155 0.4351 PLA2G4A/FCER1G/DGKG/PIK3R1/PIK3CB/PTK2B/PDGFA/RRAS2/RRAS/SYK/MRAS/ARF1/PLD2 13 KEGG hsa05415 Diabetic cardiomyopathy 17/525 203/8135 0.1619 0.5174 0.4367 CD36/CYBB/PIK3R1/SLC2A1/PIK3CB/G6PD/COX7B/NCF2/PRKCD/GSK3B/MPC1L/NDUFB4/PPP1CA/MAPK11/NFKB1/PPIF/SDHC 17 KEGG hsa04917 Prolactin signaling pathway 7/525 70/8135 0.1638 0.5174 0.4367 PIK3R1/PIK3CB/GSK3B/FOS/MAPK11/NFKB1/GCK 7 KEGG hsa05150 Staphylococcus aureus infection 9/525 96/8135 0.1656 0.5174 0.4367 C3/C3AR1/FCAR/FPR1/KRT38/ICAM1/FPR2/ITGAM/PTAFR 9 KEGG hsa00340 Histidine metabolism 3/525 22/8135 0.1662 0.5174 0.4367 HNMT/ALDH2/HAL 3 KEGG hsa04810 Regulation of actin cytoskeleton 18/525 218/8135 0.1676 0.5174 0.4367 PIK3R1/PIK3CB/CYFIP1/TIAM1/DIAPH2/PDGFA/RRAS2/PAK1/RRAS/WASF1/BRK1/PPP1CA/ITGAM/FGFR2/GSN/ITGB7/MRAS/ITGA2B 18 KEGG hsa00240 Pyrimidine metabolism 6/525 58/8135 0.1692 0.5174 0.4367 TK2/DPYD/NUDT2/ENPP1/NT5C/CDA 6 KEGG hsa05165 Human papillomavirus infection 26/525 331/8135 0.1712 0.5181 0.4373 ATP6V1B2/WNT16/PIK3R1/ATP6V1G2/PIK3CB/ATP6V0B/LAMA5/CREB3L4/FOXO1/LLGL1/ATP6V1A/GSK3B/PKM/TYK2/ATM/ATP6V0A1/MAML3/NFKB1/MPP5/ATP6V1D/LLGL2/ITGB7/AXIN2/ITGA2B/ATP6V0D1/MDM2 26 KEGG hsa05215 Prostate cancer 9/525 97/8135 0.1729 0.5181 0.4373 PIK3R1/PIK3CB/CREB3L4/FOXO1/PDGFA/GSK3B/NFKB1/FGFR2/MDM2 9 KEGG hsa04370 VEGF signaling pathway 6/525 59/8135 0.1789 0.5181 0.4373 PLA2G4A/PIK3R1/PIK3CB/MAPKAPK3/PPP3R1/MAPK11 6 KEGG hsa04915 Estrogen signaling pathway 12/525 138/8135 0.1795 0.5181 0.4373 HSPA1A/CALML4/PIK3R1/PIK3CB/CREB3L4/KRT38/PRKCD/HSPA2/FOS/ITPR2/GNAI3/GABBR2 12 KEGG hsa04750 Inflammatory mediator regulation of TRP channels 9/525 98/8135 0.1803 0.5181 0.4373 PLA2G4A/CALML4/PIK3R1/PIK3CB/PRKCD/ALOX12/PPP1CA/MAPK11/ITPR2 9 KEGG hsa05231 Choline metabolism in cancer 9/525 98/8135 0.1803 0.5181 0.4373 PLA2G4A/DGKG/PIK3R1/PIK3CB/SLC22A4/PDGFA/FOS/WASF1/PLD2 9 KEGG hsa04614 Renin-angiotensin system 3/525 23/8135 0.1825 0.5181 0.4373 ANPEP/PRCP/CTSA 3 KEGG hsa04973 Carbohydrate digestion and absorption 5/525 47/8135 0.1842 0.5181 0.4373 PIK3R1/PIK3CB/SI/HK3/AMY2A 5 KEGG hsa04668 TNF signaling pathway 10/525 112/8135 0.1855 0.5181 0.4373 PIK3R1/PIK3CB/CREB3L4/ICAM1/FOS/PGAM5/MAPK11/NFKB1/SELE/MLKL 10 KEGG hsa05162 Measles 12/525 139/8135 0.1857 0.5181 0.4373 HSPA1A/PIK3R1/PIK3CB/TLR9/TLR2/GSK3B/HSPA2/FOS/TYK2/NFKB1/IL2RB/IFIH1 12 KEGG hsa04933 AGE-RAGE signaling pathway in diabetic complications 9/525 100/8135 0.1956 0.5408 0.4565 CYBB/PIK3R1/PIK3CB/FOXO1/ICAM1/PRKCD/MAPK11/NFKB1/SELE 9 KEGG hsa00561 Glycerolipid metabolism 6/525 61/8135 0.1988 0.545 0.46 DGKG/GLA/MBOAT1/LIPF/ALDH2/GK 6 KEGG hsa05163 Human cytomegalovirus infection 18/525 225/8135 0.2024 0.5502 0.4644 ARHGEF11/CALML4/PIK3R1/PIK3CB/CREB3L4/GNG3/PTK2B/GSK3B/PPP3R1/MAPK11/NFKB1/IL10RB/GNB2/CCR1/ITPR2/NFATC3/GNAI3/MDM2 18 KEGG hsa04150 mTOR signaling pathway 13/525 156/8135 0.2067 0.5515 0.4655 ATP6V1B2/WNT16/PIK3R1/ATP6V1G2/PIK3CB/RRAGC/SLC3A2/ATP6V1A/GSK3B/PRR5/RPS6KA1/ATP6V1D/LAMTOR1 13 KEGG hsa04672 Intestinal immune network for IgA production 5/525 49/8135 0.2071 0.5515 0.4655 CD86/LTBR/TNFRSF13C/TNFRSF13B/ITGB7 5 KEGG hsa04621 NOD-like receptor signaling pathway 15/525 184/8135 0.2081 0.5515 0.4655 CYBB/MAP1LC3B/P2RX7/NLRC4/YWHAE/CARD6/PRKCD/NAIP/TYK2/CTSB/MAPK11/NFKB1/NLRP12/ITPR2/NLRP3 15 KEGG hsa01250 Biosynthesis of nucleotide sugars 4/525 37/8135 0.214 0.5603 0.4729 HK3/GCK/FPGT/NAGK 4 KEGG hsa04211 Longevity regulating pathway 8/525 89/8135 0.215 0.5603 0.4729 KL/PIK3R1/PIK3CB/CREB3L4/FOXO1/NFKB1/CAT/PPARG 8 KEGG hsa04068 FoxO signaling pathway 11/525 131/8135 0.2244 0.5754 0.4857 SETD7/PIK3R1/PIK3CB/FOXO1/S1PR1/PLK2/ATM/MAPK11/CAT/PLK3/MDM2 11 KEGG hsa04650 Natural killer cell mediated cytotoxicity 11/525 131/8135 0.2244 0.5754 0.4857 FCER1G/TNFRSF10B/PIK3R1/PIK3CB/PTK2B/IFNGR1/PAK1/ICAM1/PPP3R1/SYK/IFNGR2 11 KEGG hsa05340 Primary immunodeficiency 4/525 38/8135 0.228 0.5799 0.4895 TNFRSF13C/TNFRSF13B/CD79A/BLNK 4 KEGG hsa00330 Arginine and proline metabolism 5/525 51/8135 0.2309 0.5828 0.492 P4HA1/SAT2/ALDH2/AZIN2/SAT1 5 KEGG hsa05321 Inflammatory bowel disease 6/525 65/8135 0.2409 0.6032 0.5092 TLR2/IFNGR1/STAT4/TLR5/IFNGR2/NFKB1 6 KEGG hsa04928 Parathyroid hormone synthesis, secretion and action 9/525 106/8135 0.2443 0.6061 0.5116 ARHGEF11/KL/CREB3L4/FOS/PDE4C/VDR/ITPR2/GNAI3/PLD2 9 KEGG hsa04152 AMPK signaling pathway 10/525 120/8135 0.2459 0.6061 0.5116 CD36/PIK3R1/CPT1A/PIK3CB/CREB3L4/FOXO1/PFKFB4/FBP1/PPARG/FASN 10 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 3/525 27/8135 0.2514 0.6115 0.5162 ELOVL1/ACAA1/ACOX1 3 KEGG hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 2/525 15/8135 0.2519 0.6115 0.5162 GLA/NAGA 2 KEGG hsa04961 Endocrine and other factor-regulated calcium reabsorption 5/525 53/8135 0.2555 0.615 0.5191 KL/SLC8A1/CLTA/CLTC/VDR 5 KEGG hsa04062 Chemokine signaling pathway 15/525 192/8135 0.2572 0.615 0.5191 CXCL16/PIK3R1/PIK3CB/CXCL11/TIAM1/HCK/GNG3/PTK2B/PAK1/PRKCD/GSK3B/NFKB1/GNB2/CCR1/GNAI3 15 KEGG hsa04657 IL-17 signaling pathway 8/525 94/8135 0.2599 0.6168 0.5207 S100A9/GSK3B/CSF3/S100A8/FOS/MAPK11/NFKB1/IL17RA 8 KEGG hsa04720 Long-term potentiation 6/525 67/8135 0.2629 0.6193 0.5227 GRIA2/CALML4/PPP3R1/RPS6KA1/PPP1CA/ITPR2 6 KEGG hsa04664 Fc epsilon RI signaling pathway 6/525 68/8135 0.2741 0.6409 0.541 PLA2G4A/FCER1G/PIK3R1/PIK3CB/SYK/MAPK11 6 KEGG hsa00430 Taurine and hypotaurine metabolism 2/525 16/8135 0.2765 0.6418 0.5417 FMO5/GGT6 2 KEGG hsa04371 Apelin signaling pathway 11/525 139/8135 0.2852 0.6432 0.5429 CALML4/MAP1LC3B/GNG3/SLC8A1/HDAC5/RRAS2/RRAS/GNB2/ITPR2/GNAI3/MRAS 11 KEGG hsa04924 Renin secretion 6/525 69/8135 0.2854 0.6432 0.5429 CALML4/PPP3R1/CTSB/KCNJ2/ITPR2/GNAI3 6 KEGG hsa05031 Amphetamine addiction 6/525 69/8135 0.2854 0.6432 0.5429 GRIA2/CALML4/CREB3L4/PPP3R1/FOS/PPP1CA 6 KEGG hsa04392 Hippo signaling pathway - multiple species 3/525 29/8135 0.2872 0.6432 0.5429 STK3/PAK1/RASSF2 3 KEGG hsa04744 Phototransduction 3/525 29/8135 0.2872 0.6432 0.5429 CALML4/SAG/GUCY2D 3 KEGG hsa05130 Pathogenic Escherichia coli infection 15/525 197/8135 0.2899 0.6447 0.5442 ARHGEF11/TNFRSF10B/CYFIP1/PAK1/TLR5/NAIP/FOS/WASF1/TUBA1A/BRK1/TUBA4A/MAPK11/NFKB1/NLRP3/ARF1 15 KEGG hsa04932 Non-alcoholic fatty liver disease 12/525 155/8135 0.2985 0.6546 0.5525 PIK3R1/PIK3CB/MLX/COX7B/GSK3B/FOS/NDUFB4/MAPK11/NFKB1/CYP2E1/PPARG/SDHC 12 KEGG hsa04934 Cushing syndrome 12/525 155/8135 0.2985 0.6546 0.5525 WNT16/CREB3L4/NCEH1/CRHR2/KCNK2/GSK3B/ARNT/AHR/MRAP/ITPR2/AXIN2/GNAI3 12 KEGG hsa00053 Ascorbate and aldarate metabolism 3/525 30/8135 0.3053 0.6604 0.5574 KL/ALDH2/UGT2A2 3 KEGG hsa01523 Antifolate resistance 3/525 30/8135 0.3053 0.6604 0.5574 MTHFR/ALOX12/NFKB1 3 KEGG hsa04390 Hippo signaling pathway 12/525 157/8135 0.3138 0.6709 0.5663 WNT16/STK3/CTNNA1/YWHAE/DLG4/LLGL1/GSK3B/PPP1CA/MPP5/AMH/LLGL2/AXIN2 12 KEGG hsa04962 Vasopressin-regulated water reabsorption 4/525 44/8135 0.3154 0.6709 0.5663 CREB3L4/NSF/DYNC1LI2/RAB5B 4 KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells 11/525 143/8135 0.3173 0.6709 0.5663 KLF4/WNT16/HAND1/PIK3R1/PIK3CB/GSK3B/TCF3/MAPK11/FGFR2/INHBE/AXIN2 11 KEGG hsa05218 Melanoma 6/525 72/8135 0.3198 0.6709 0.5663 PIK3R1/PIK3CB/PDGFA/POLK/HGF/MDM2 6 KEGG hsa04926 Relaxin signaling pathway 10/525 129/8135 0.3207 0.6709 0.5663 PIK3R1/PIK3CB/CREB3L4/GNA15/GNG3/FOS/MAPK11/NFKB1/GNB2/GNAI3 10 KEGG hsa00410 beta-Alanine metabolism 3/525 31/8135 0.3234 0.6721 0.5673 DPYD/ALDH2/ACOX1 3 KEGG hsa01524 Platinum drug resistance 6/525 73/8135 0.3314 0.6813 0.5751 PIK3R1/PIK3CB/MGST1/GSTA2/ATM/MDM2 6 KEGG hsa04330 Notch signaling pathway 5/525 59/8135 0.3321 0.6813 0.5751 NCSTN/KAT2A/ADAM17/NUMB/MAML3 5 KEGG hsa04914 Progesterone-mediated oocyte maturation 8/525 102/8135 0.3368 0.6865 0.5795 PIK3R1/PIK3CB/SPDYE2/KIF22/SPDYE3/RPS6KA1/MAPK11/GNAI3 8 KEGG hsa00640 Propanoate metabolism 3/525 32/8135 0.3415 0.6916 0.5838 ACSS2/ACOX1/BCKDHB 3 KEGG hsa04630 JAK-STAT signaling pathway 12/525 162/8135 0.353 0.7052 0.5953 PIK3R1/PIK3CB/IFNGR1/PDGFA/STAT4/MCL1/CSF3/TYK2/CSF2RA/IFNGR2/IL10RB/IL2RB 12 KEGG hsa05161 Hepatitis B 12/525 162/8135 0.353 0.7052 0.5953 PIK3R1/PIK3CB/CREB3L4/PTK2B/TLR2/STAT4/FOS/TYK2/MAPK11/NFKB1/NFATC3/IFIH1 12 KEGG hsa05214 Glioma 6/525 75/8135 0.3548 0.7052 0.5953 CALML4/PIK3R1/PIK3CB/PDGFA/POLK/MDM2 6 KEGG hsa04935 Growth hormone synthesis, secretion and action 9/525 119/8135 0.3609 0.707 0.5967 PIK3R1/PIK3CB/CREB3L4/GSK3B/IGFBP3/FOS/MAPK11/ITPR2/GNAI3 9 KEGG hsa00190 Oxidative phosphorylation 10/525 134/8135 0.3642 0.707 0.5967 ATP6V1B2/ATP6V1G2/ATP6V0B/COX7B/ATP6V1A/NDUFB4/ATP6V0A1/ATP6V1D/SDHC/ATP6V0D1 10 KEGG hsa04971 Gastric acid secretion 6/525 76/8135 0.3666 0.707 0.5967 CALML4/KCNJ16/KCNK2/KCNJ2/ITPR2/GNAI3 6 KEGG hsa05220 Chronic myeloid leukemia 6/525 76/8135 0.3666 0.707 0.5967 PIK3R1/PIK3CB/POLK/CBL/NFKB1/MDM2 6 KEGG hsa04514 Cell adhesion molecules 11/525 149/8135 0.3668 0.707 0.5967 PECAM1/VCAN/CD86/ICAM1/NLGN2/ALCAM/LRRC4C/SDC4/ITGAM/SELE/ITGB7 11 KEGG hsa00670 One carbon pool by folate 2/525 20/8135 0.3734 0.7123 0.6013 MTHFR/MTHFS 2 KEGG hsa00280 Valine, leucine and isoleucine degradation 4/525 48/8135 0.3753 0.7123 0.6013 HADHB/ALDH2/ACAA1/BCKDHB 4 KEGG hsa00040 Pentose and glucuronate interconversions 3/525 34/8135 0.3775 0.7123 0.6013 KL/SORD/UGT2A2 3 KEGG hsa04015 Rap1 signaling pathway 15/525 210/8135 0.3799 0.7123 0.6013 CALML4/PIK3R1/PIK3CB/TIAM1/FPR1/PDGFA/RRAS/HGF/MAPK11/ITGAM/FGFR2/SIPA1L2/GNAI3/MRAS/ITGA2B 15 KEGG hsa04020 Calcium signaling pathway 17/525 240/8135 0.3808 0.7123 0.6013 CALML4/GNA15/P2RX7/PTK2B/SLC8A1/P2RX5/PDGFA/PPP3R1/HGF/DRD5/TACR1/FGFR2/P2RX1/PHKB/PPIF/ITPR2/PTAFR 17 KEGG hsa03250 Viral life cycle - HIV-1 5/525 63/8135 0.3844 0.7148 0.6034 KAT2A/TSG101/TNPO3/APOBEC3D/RANBP2 5 KEGG hsa00565 Ether lipid metabolism 4/525 49/8135 0.3903 0.7216 0.6091 PLA2G4A/PLA2G1B/PLB1/PLD2 4 KEGG hsa04929 GnRH secretion 5/525 64/8135 0.3974 0.7302 0.6164 PIK3R1/PIK3CB/GNRH1/ITPR2/GABBR2 5 KEGG hsa05225 Hepatocellular carcinoma 12/525 168/8135 0.4009 0.7302 0.6164 WNT16/PIK3R1/PIK3CB/MGST1/FRAT1/GSTA2/SMARCD3/GSK3B/POLK/PHF10/HGF/AXIN2 12 KEGG hsa01521 EGFR tyrosine kinase inhibitor resistance 6/525 79/8135 0.4018 0.7302 0.6164 PIK3R1/PIK3CB/PDGFA/GSK3B/HGF/FGFR2 6 KEGG hsa04927 Cortisol synthesis and secretion 5/525 65/8135 0.4105 0.7417 0.626 CREB3L4/NCEH1/KCNK2/MRAP/ITPR2 5 KEGG hsa00760 Nicotinate and nicotinamide metabolism 3/525 36/8135 0.4131 0.7422 0.6265 BST1/ENPP1/NT5C 3 KEGG hsa05164 Influenza A 12/525 171/8135 0.425 0.753 0.6356 TNFRSF10B/PIK3R1/PIK3CB/IFNGR1/RAE1/ICAM1/CALCOCO2/TYK2/IFNGR2/NFKB1/NLRP3/IFIH1 12 KEGG hsa05171 Coronavirus disease - COVID-19 16/525 232/8135 0.4288 0.753 0.6356 TLR8/CYBB/PIK3R1/C3/C3AR1/PIK3CB/ADAM17/TLR2/CSF3/SYK/FOS/TYK2/MAPK11/NFKB1/NLRP3/IFIH1 16 KEGG hsa05143 African trypanosomiasis 3/525 37/8135 0.4307 0.753 0.6356 TLR9/ICAM1/SELE 3 KEGG hsa05216 Thyroid cancer 3/525 37/8135 0.4307 0.753 0.6356 POLK/NCOA4/PPARG 3 KEGG hsa05169 Epstein-Barr virus infection 14/525 202/8135 0.431 0.753 0.6356 VIM/PIK3R1/PIK3CB/CD44/TLR2/ICAM1/POLK/SYK/TYK2/RUNX3/MAPK11/NFKB1/BLNK/MDM2 14 KEGG hsa04713 Circadian entrainment 7/525 97/8135 0.4369 0.7552 0.6375 GRIA2/CALML4/GNG3/FOS/PER3/GNB2/GNAI3 7 KEGG hsa04146 Peroxisome 6/525 82/8135 0.437 0.7552 0.6375 ACSL3/ACAA1/IDH1/ACOX1/ACSL1/CAT 6 KEGG hsa04060 Cytokine-cytokine receptor interaction 20/525 295/8135 0.4429 0.7582 0.64 EDA2R/TNFRSF10B/CXCL16/CXCL11/TNFRSF4/IFNGR1/GDF2/IL1RN/CSF3/LTBR/TNFRSF13C/TNFRSF13B/CSF2RA/IFNGR2/IL10RB/AMH/CCR1/INHBE/IL2RB/IL17RA 20 KEGG hsa00230 Purine metabolism 9/525 128/8135 0.4452 0.7582 0.64 AMPD3/PPAT/NUDT2/PAPSS1/PDE4C/ENPP1/GUCY2D/NT5C/IMPDH1 9 KEGG hsa05203 Viral carcinogenesis 14/525 204/8135 0.4458 0.7582 0.64 KAT2A/PIK3R1/C3/PIK3CB/CREB3L4/YWHAE/HDAC5/PKM/LTBR/SYK/NFKB1/GSN/ATP6V0D1/MDM2 14 KEGG hsa01232 Nucleotide metabolism 6/525 85/8135 0.4718 0.796 0.6719 TK2/AMPD3/ENPP1/NT5C/CDA/IMPDH1 6 KEGG hsa04114 Oocyte meiosis 9/525 131/8135 0.4731 0.796 0.6719 CALML4/YWHAE/SPDYE2/PPP3R1/SPDYE3/RPS6KA1/PPP1CA/MAPK11/ITPR2 9 KEGG hsa05210 Colorectal cancer 6/525 86/8135 0.4832 0.8022 0.6771 PIK3R1/PIK3CB/GSK3B/POLK/FOS/AXIN2 6 KEGG hsa00920 Sulfur metabolism 1/525 10/8135 0.487 0.8022 0.6771 PAPSS1 1 KEGG hsa05226 Gastric cancer 10/525 149/8135 0.4965 0.8022 0.6771 WNT16/PIK3R1/PIK3CB/CTNNA1/FRAT1/GSK3B/POLK/HGF/FGFR2/AXIN2 10 KEGG hsa05020 Prion disease 18/525 273/8135 0.4982 0.8022 0.6771 HSPA1A/CYBB/PIK3R1/PIK3CB/CREB3L4/COX7B/NCF2/PRKCD/GSK3B/HSPA2/PPP3R1/NDUFB4/TUBA1A/TUBA4A/MAPK11/PPIF/ITPR2/SDHC 18 KEGG hsa03440 Homologous recombination 3/525 41/8135 0.4988 0.8022 0.6771 UIMC1/ATM/TOP3A 3 KEGG hsa00982 Drug metabolism - cytochrome P450 5/525 72/8135 0.5 0.8022 0.6771 FMO5/MGST1/GSTA2/CYP2E1/UGT2A2 5 KEGG hsa05223 Non-small cell lung cancer 5/525 72/8135 0.5 0.8022 0.6771 PIK3R1/PIK3CB/POLK/HGF/EML4 5 KEGG hsa05207 Chemical carcinogenesis - receptor activation 14/525 212/8135 0.5048 0.8022 0.6771 KLF4/PIK3R1/PIK3CB/CREB3L4/MGST1/GSTA2/ARNT/FOS/RPS6KA1/NFKB1/AHR/VDR/UGT2A2/GNAI3 14 KEGG hsa04512 ECM-receptor interaction 6/525 88/8135 0.5059 0.8022 0.6771 CD36/LAMA5/CD44/SDC4/ITGB7/ITGA2B 6 KEGG hsa04540 Gap junction 6/525 88/8135 0.5059 0.8022 0.6771 PDGFA/GJD2/TUBA1A/TUBA4A/ITPR2/GNAI3 6 KEGG hsa04950 Maturity onset diabetes of the young 2/525 26/8135 0.5073 0.8022 0.6771 BHLHA15/GCK 2 KEGG hsa04115 p53 signaling pathway 5/525 73/8135 0.5124 0.8022 0.6771 TNFRSF10B/IGFBP3/ATM/MDM2/PERP 5 KEGG hsa05010 Alzheimer disease 25/525 384/8135 0.5127 0.8022 0.6771 CALML4/CYBB/CAPN2/NCSTN/RTN4/WNT16/PIK3R1/SLC39A9/PIK3CB/ADAM17/FRAT1/CDK5/COX7B/RTN3/GSK3B/PPP3R1/NDUFB4/TUBA1A/TUBA4A/NFKB1/PPIF/ITPR2/LRP1/AXIN2/SDHC 25 KEGG hsa00380 Tryptophan metabolism 3/525 42/8135 0.5152 0.8022 0.6771 ALDH2/HAAO/CAT 3 KEGG hsa04727 GABAergic synapse 6/525 89/8135 0.5171 0.8022 0.6771 NSF/GNG3/SLC6A13/GNB2/GNAI3/GABBR2 6 KEGG hsa04976 Bile secretion 6/525 89/8135 0.5171 0.8022 0.6771 SLC2A1/AQP9/NCEH1/SLC51B/UGT2A2/AQP8 6 KEGG hsa00062 Fatty acid elongation 2/525 27/8135 0.5277 0.8147 0.6877 ELOVL1/HADHB 2 KEGG hsa04975 Fat digestion and absorption 3/525 43/8135 0.5313 0.8161 0.6889 CD36/LIPF/PLA2G1B 3 KEGG hsa04510 Focal adhesion 13/525 201/8135 0.5387 0.8235 0.6951 RASGRF1/CAPN2/PIK3R1/PIK3CB/LAMA5/PDGFA/PAK1/GSK3B/ILK/HGF/PPP1CA/ITGB7/ITGA2B 13 KEGG hsa04730 Long-term depression 4/525 60/8135 0.5477 0.8252 0.6965 GRIA2/PLA2G4A/ITPR2/GNAI3 4 KEGG hsa05212 Pancreatic cancer 5/525 76/8135 0.5488 0.8252 0.6965 PIK3R1/PIK3CB/POLK/NFKB1/PLD2 5 KEGG hsa04141 Protein processing in endoplasmic reticulum 11/525 171/8135 0.5498 0.8252 0.6965 HSPA1A/CAPN2/UBE4B/DERL3/FBXO6/AMFR/HSPA2/DNAJA1/OS9/DERL1/SEL1L2 11 KEGG hsa05222 Small cell lung cancer 6/525 92/8135 0.5501 0.8252 0.6965 PIK3R1/PIK3CB/LAMA5/POLK/NFKB1/ITGA2B 6 KEGG hsa04612 Antigen processing and presentation 5/525 78/8135 0.5723 0.8544 0.7212 HSPA1A/IFI30/HSPA2/CTSB/CTSS 5 KEGG hsa03450 Non-homologous end-joining 1/525 13/8135 0.5802 0.8601 0.726 FEN1 1 KEGG hsa00020 Citrate cycle (TCA cycle) 2/525 30/8135 0.5856 0.8601 0.726 IDH1/SDHC 2 KEGG hsa00630 Glyoxylate and dicarboxylate metabolism 2/525 30/8135 0.5856 0.8601 0.726 ACSS2/CAT 2 KEGG hsa05217 Basal cell carcinoma 4/525 63/8135 0.5869 0.8601 0.726 WNT16/GSK3B/POLK/AXIN2 4 KEGG hsa00514 Other types of O-glycan biosynthesis 3/525 47/8135 0.5925 0.8603 0.7262 GALNT18/GALNT7/ST6GAL1 3 KEGG hsa00620 Pyruvate metabolism 3/525 47/8135 0.5925 0.8603 0.7262 ACSS2/ALDH2/PKM 3 KEGG hsa04710 Circadian rhythm 2/525 31/8135 0.6037 0.8726 0.7366 PER3/BHLHE41 2 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/525 14/8135 0.6073 0.8739 0.7376 B3GNT7 1 KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 6/525 100/8135 0.6326 0.9022 0.7616 TNFRSF10B/CXCL11/LTBR/IL10RB/CCR1/IL2RB 6 KEGG hsa00604 Glycosphingolipid biosynthesis - ganglio series 1/525 15/8135 0.6327 0.9022 0.7616 GLB1 1 KEGG hsa04130 SNARE interactions in vesicular transport 2/525 33/8135 0.6381 0.9058 0.7646 STX11/STX6 2 KEGG hsa04310 Wnt signaling pathway 10/525 167/8135 0.6437 0.9097 0.7679 WNT16/PRICKLE2/CTNNBIP1/FRAT1/RSPO1/GSK3B/PPP3R1/TBL1X/NFATC3/AXIN2 10 KEGG hsa04012 ErbB signaling pathway 5/525 85/8135 0.6492 0.9135 0.7711 PIK3R1/PIK3CB/PAK1/GSK3B/CBL 5 KEGG hsa05204 Chemical carcinogenesis - DNA adducts 4/525 69/8135 0.6591 0.9222 0.7784 MGST1/GSTA2/CYP2E1/UGT2A2 4 KEGG hsa04974 Protein digestion and absorption 6/525 103/8135 0.6612 0.9222 0.7784 XPNPEP2/KCNE3/SLC7A7/SLC8A1/PRCP/SLC3A2 6 KEGG hsa04921 Oxytocin signaling pathway 9/525 154/8135 0.6697 0.925 0.7808 PLA2G4A/CALML4/PPP3R1/FOS/PPP1CA/KCNJ2/ITPR2/NFATC3/GNAI3 9 KEGG hsa04622 RIG-I-like receptor signaling pathway 4/525 70/8135 0.6702 0.925 0.7808 AZI2/MAPK11/NFKB1/IFIH1 4 KEGG hsa04919 Thyroid hormone signaling pathway 7/525 121/8135 0.6722 0.925 0.7808 KAT2A/PIK3R1/SLC2A1/PIK3CB/FOXO1/GSK3B/MDM2 7 KEGG hsa00120 Primary bile acid biosynthesis 1/525 17/8135 0.6787 0.925 0.7808 CYP27A1 1 KEGG hsa00450 Selenocompound metabolism 1/525 17/8135 0.6787 0.925 0.7808 PAPSS1 1 KEGG hsa00512 Mucin type O-glycan biosynthesis 2/525 36/8135 0.6852 0.925 0.7808 GALNT18/GALNT7 2 KEGG hsa04080 Neuroactive ligand-receptor interaction 21/525 353/8135 0.6854 0.925 0.7808 GRIA2/TAAR5/C3/C3AR1/P2RX7/PYY/GNRH1/CNR2/P2RX5/FPR1/CRHR2/S1PR1/P2RY10/FPR2/DRD5/GRIK1/TACR1/P2RX1/P2RY13/PTAFR/GABBR2 21 KEGG hsa03460 Fanconi anemia pathway 3/525 54/8135 0.6865 0.925 0.7808 POLK/FANCM/TOP3A 3 KEGG hsa04151 PI3K-Akt signaling pathway 21/525 354/8135 0.6904 0.9263 0.7819 PIK3R1/PIK3CB/LAMA5/CREB3L4/GNG3/YWHAE/TLR2/PDGFA/MCL1/GSK3B/CSF3/SYK/HGF/NFKB1/FGFR2/CDC37/GNB2/ITGB7/IL2RB/ITGA2B/MDM2 21 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 2/525 37/8135 0.6997 0.9349 0.7891 PIK3R1/PIK3CB 2 KEGG hsa03013 Nucleocytoplasmic transport 6/525 108/8135 0.7056 0.9358 0.7899 RAE1/RANGAP1/NUP88/SUMO1/TNPO3/RANBP2 6 KEGG hsa05032 Morphine addiction 5/525 91/8135 0.7077 0.9358 0.7899 GNG3/PDE4C/GNB2/GNAI3/GABBR2 5 KEGG hsa04923 Regulation of lipolysis in adipocytes 3/525 56/8135 0.7101 0.9358 0.7899 PIK3R1/PIK3CB/GNAI3 3 KEGG hsa04110 Cell cycle 7/525 126/8135 0.7128 0.9358 0.7899 DBF4/YWHAE/GSK3B/ATM/BUB1B/E2F5/MDM2 7 KEGG hsa01210 2-Oxocarboxylic acid metabolism 1/525 19/8135 0.7189 0.9358 0.7899 IDH1 1 KEGG hsa04970 Salivary secretion 5/525 93/8135 0.7256 0.9358 0.7899 CALML4/BST1/SLC12A2/AMY2A/ITPR2 5 KEGG hsa05022 Pathways of neurodegeneration - multiple diseases 28/525 476/8135 0.7269 0.9358 0.7899 GRIA2/CALML4/CYBB/CAPN2/WNT16/MAP1LC3B/FRAT1/DLG4/DNAH7/CDK5/COX7B/GSK3B/PPP3R1/NDUFB4/SQSTM1/TUBA1A/ACTR1A/TUBA4A/MAPK11/NFKB1/WDR41/DERL1/CAT/PPIF/ITPR2/UCHL1/AXIN2/SDHC 28 KEGG hsa00100 Steroid biosynthesis 1/525 20/8135 0.7371 0.9358 0.7899 NSDHL 1 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/525 20/8135 0.7371 0.9358 0.7899 CHST12 1 KEGG hsa05033 Nicotine addiction 2/525 40/8135 0.74 0.9358 0.7899 GRIA2/SLC17A7 2 KEGG hsa05224 Breast cancer 8/525 147/8135 0.741 0.9358 0.7899 WNT16/PIK3R1/PIK3CB/FRAT1/GSK3B/POLK/FOS/AXIN2 8 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy 4/525 77/8135 0.7413 0.9358 0.7899 CTNNA1/SLC8A1/ITGB7/ITGA2B 4 KEGG hsa04714 Thermogenesis 13/525 232/8135 0.742 0.9358 0.7899 NDUFAF1/CPT1A/CREB3L4/ZNF516/COX7B/SMARCD3/ACSL3/NDUFB4/RPS6KA1/MAPK11/ACSL1/PPARG/SDHC 13 KEGG hsa04723 Retrograde endocannabinoid signaling 8/525 148/8135 0.7477 0.9358 0.7899 GRIA2/GNG3/NDUFB4/MAPK11/GNB2/ITPR2/SLC17A7/GNAI3 8 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 4/525 78/8135 0.7504 0.9358 0.7899 MGST1/GSTA2/CYP2E1/UGT2A2 4 KEGG hsa05219 Bladder cancer 2/525 41/8135 0.7524 0.9358 0.7899 DAPK1/MDM2 2 KEGG hsa04978 Mineral absorption 3/525 60/8135 0.7533 0.9358 0.7899 SLC8A1/FTL/VDR 3 KEGG hsa05416 Viral myocarditis 3/525 60/8135 0.7533 0.9358 0.7899 CD86/ICAM1/EIF4G2 3 KEGG hsa04022 cGMP-PKG signaling pathway 9/525 167/8135 0.7591 0.9371 0.791 CALML4/CREB3L4/SLC8A1/PPP3R1/PPP1CA/PPIF/ITPR2/NFATC3/GNAI3 9 KEGG hsa04726 Serotonergic synapse 6/525 115/8135 0.7608 0.9371 0.791 PLA2G4A/GNG3/ALOX12/GNB2/ITPR2/GNAI3 6 KEGG hsa00140 Steroid hormone biosynthesis 3/525 61/8135 0.7633 0.9371 0.791 HSD17B1/CYP2E1/UGT2A2 3 KEGG hsa01522 Endocrine resistance 5/525 98/8135 0.7669 0.938 0.7918 PIK3R1/PIK3CB/FOS/MAPK11/MDM2 5 KEGG hsa04270 Vascular smooth muscle contraction 7/525 134/8135 0.7704 0.9387 0.7924 PLA2G4A/ARHGEF11/CALML4/PRKCD/PLA2G1B/PPP1CA/ITPR2 7 KEGG hsa04940 Type I diabetes mellitus 2/525 43/8135 0.7756 0.9413 0.7945 CD86/HSPD1 2 KEGG hsa04740 Olfactory transduction 25/525 440/8135 0.7785 0.9413 0.7945 OR10G8/OR2B11/OR5J2/CALML4/OR52I2/OR5M11/OR2AT4/SLC8A1/OR5A1/OR2T29/OR7A5/OR6C3/OR8K3/OR5B17/OR2T27/OR4C11/NCALD/OR14J1/OR56B4/GUCY2D/OR2B3/OR4N5/OR51M1/OR8B4/OR2D2 25 KEGG hsa00310 Lysine degradation 3/525 63/8135 0.7822 0.9422 0.7953 SETD7/ALDH2/PRDM2 3 KEGG hsa04916 Melanogenesis 5/525 101/8135 0.7894 0.9472 0.7995 CALML4/WNT16/CREB3L4/GSK3B/GNAI3 5 KEGG hsa04972 Pancreatic secretion 5/525 102/8135 0.7964 0.9478 0.8001 BST1/SLC12A2/AMY2A/PLA2G1B/ITPR2 5 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/525 24/8135 0.7988 0.9478 0.8001 GLCE 1 KEGG hsa04977 Vitamin digestion and absorption 1/525 24/8135 0.7988 0.9478 0.8001 PLB1 1 KEGG hsa04911 Insulin secretion 4/525 86/8135 0.8147 0.9631 0.813 SLC2A1/CREB3L4/ABCC8/GCK 4 KEGG hsa04120 Ubiquitin mediated proteolysis 7/525 142/8135 0.8192 0.9634 0.8132 RNF7/UBE2F/UBE4B/UBE2W/UBE2R2/CBL/MDM2 7 KEGG hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/525 26/8135 0.824 0.9634 0.8132 PIGB 1 KEGG hsa00790 Folate biosynthesis 1/525 26/8135 0.824 0.9634 0.8132 PCBD1 1 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/525 27/8135 0.8354 0.9731 0.8214 ST3GAL6 1 KEGG hsa04520 Adherens junction 3/525 71/8135 0.8458 0.9816 0.8285 CTNNA1/PTPRJ/WASF1 3 KEGG hsa04913 Ovarian steroidogenesis 2/525 51/8135 0.8504 0.9834 0.8301 PLA2G4A/HSD17B1 2 KEGG hsa04530 Tight junction 8/525 169/8135 0.862 0.9931 0.8383 TIAM1/CD1A/AMOTL2/LLGL1/TUBA1A/TUBA4A/MPP5/LLGL2 8 KEGG hsa04918 Thyroid hormone synthesis 3/525 75/8135 0.871 0.9961 0.8408 CREB3L4/ASGR2/ITPR2 3 KEGG hsa05310 Asthma 1/525 31/8135 0.8741 0.9961 0.8408 FCER1G 1 KEGG hsa03015 mRNA surveillance pathway 4/525 97/8135 0.8804 0.9961 0.8408 CLP1/ETF1/PPP1CA/MSI2 4 KEGG hsa04136 Autophagy - other 1/525 32/8135 0.8822 0.9961 0.8408 ATG7 1 KEGG hsa03410 Base excision repair 1/525 33/8135 0.8899 0.9961 0.8408 FEN1 1 KEGG hsa03018 RNA degradation 3/525 79/8135 0.8926 0.9961 0.8408 XRN2/HSPD1/EXOSC7 3 KEGG hsa03020 RNA polymerase 1/525 34/8135 0.897 0.9961 0.8408 POLR3E 1 KEGG hsa05016 Huntington disease 15/525 306/8135 0.8973 0.9961 0.8408 GRIA2/CREB3L4/DLG4/DNAH7/CLTA/COX7B/CLTC/NDUFB4/TUBA1A/ACTR1A/TUBA4A/PPIF/RCOR1/PPARG/SDHC 15 KEGG hsa05206 MicroRNAs in cancer 15/525 310/8135 0.9073 0.9961 0.8408 VIM/ZEB2/PIK3R1/PIK3CB/CD44/MARCKS/MIR199B/PDGFA/HDAC5/MCL1/MIR21/ATM/NFKB1/MIR199A1/MDM2 15 KEGG hsa05014 Amyotrophic lateral sclerosis 18/525 364/8135 0.9086 0.9961 0.8408 GRIA2/MAP1LC3B/DNAH7/RAE1/COX7B/NUP88/PPP3R1/NDUFB4/SQSTM1/TUBA1A/ACTR1A/TUBA4A/MAPK11/WDR41/DERL1/CAT/SDHC/RANBP2 18 KEGG hsa00350 Tyrosine metabolism 1/525 36/8135 0.9099 0.9961 0.8408 FAH 1 KEGG hsa03030 DNA replication 1/525 36/8135 0.9099 0.9961 0.8408 FEN1 1 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 1/525 37/8135 0.9158 0.9961 0.8408 PPAT 1 KEGG hsa04623 Cytosolic DNA-sensing pathway 2/525 63/8135 0.9209 0.9961 0.8408 NFKB1/POLR3E 2 KEGG hsa05330 Allograft rejection 1/525 38/8135 0.9212 0.9961 0.8408 CD86 1 KEGG hsa04261 Adrenergic signaling in cardiomyocytes 6/525 150/8135 0.9284 0.9961 0.8408 CALML4/CREB3L4/SLC8A1/PPP1CA/MAPK11/GNAI3 6 KEGG hsa00260 Glycine, serine and threonine metabolism 1/525 40/8135 0.9311 0.9961 0.8408 PGAM4 1 KEGG hsa05410 Hypertrophic cardiomyopathy 3/525 90/8135 0.9362 0.9961 0.8408 SLC8A1/ITGB7/ITGA2B 3 KEGG hsa05332 Graft-versus-host disease 1/525 42/8135 0.9398 0.9961 0.8408 CD86 1 KEGG hsa00830 Retinol metabolism 2/525 68/8135 0.9398 0.9961 0.8408 SDR16C5/UGT2A2 2 KEGG hsa00860 Porphyrin metabolism 1/525 43/8135 0.9437 0.9961 0.8408 UGT2A2 1 KEGG hsa05160 Hepatitis C 6/525 157/8135 0.9453 0.9961 0.8408 PIK3R1/PIK3CB/YWHAE/GSK3B/TYK2/NFKB1 6 KEGG hsa04350 TGF-beta signaling pathway 3/525 94/8135 0.9475 0.9961 0.8408 AMH/INHBE/E2F5 3 KEGG hsa02010 ABC transporters 1/525 45/8135 0.9507 0.9961 0.8408 ABCC8 1 KEGG hsa03022 Basal transcription factors 1/525 45/8135 0.9507 0.9961 0.8408 MNAT1 1 KEGG hsa05414 Dilated cardiomyopathy 3/525 96/8135 0.9524 0.9961 0.8408 SLC8A1/ITGB7/ITGA2B 3 KEGG hsa04925 Aldosterone synthesis and secretion 3/525 98/8135 0.9569 0.9961 0.8408 CALML4/CREB3L4/ITPR2 3 KEGG hsa03420 Nucleotide excision repair 1/525 47/8135 0.9569 0.9961 0.8408 MNAT1 1 KEGG hsa05017 Spinocerebellar ataxia 5/525 143/8135 0.9585 0.9961 0.8408 GRIA2/PIK3R1/PIK3CB/PPIF/ITPR2 5 KEGG hsa05012 Parkinson disease 11/525 266/8135 0.9619 0.9961 0.8408 CALML4/SLC39A9/COX7B/NDUFB4/TUBA1A/TUBA4A/PPIF/ITPR2/UCHL1/GNAI3/SDHC 11 KEGG hsa05034 Alcoholism 7/525 187/8135 0.9623 0.9961 0.8408 CALML4/CREB3L4/GNG3/HDAC5/PPP1CA/GNB2/GNAI3 7 KEGG hsa00510 N-Glycan biosynthesis 1/525 50/8135 0.9648 0.9961 0.8408 ST6GAL1 1 KEGG hsa05320 Autoimmune thyroid disease 1/525 53/8135 0.9712 0.9993 0.8435 CD86 1 KEGG hsa04340 Hedgehog signaling pathway 1/525 56/8135 0.9765 0.9993 0.8435 GSK3B 1 KEGG hsa04260 Cardiac muscle contraction 2/525 87/8135 0.9793 0.9993 0.8435 SLC8A1/COX7B 2 KEGG hsa00970 Aminoacyl-tRNA biosynthesis 1/525 66/8135 0.988 0.9993 0.8435 AARS2 1 KEGG hsa01240 Biosynthesis of cofactors 4/525 153/8135 0.9909 0.9993 0.8435 SDR16C5/ALDH2/HAAO/UGT2A2 4 KEGG hsa05168 Herpes simplex virus 1 infection 20/525 495/8135 0.9935 0.9993 0.8435 PIK3R1/CFP/C3/PIK3CB/ZNF425/TLR9/TLR2/IFNGR1/ZNF251/ZNF517/SYK/TYK2/ZNF766/ZNF479/IFNGR2/PPP1CA/NFKB1/ZNF354B/ZNF324B/IFIH1 20 KEGG hsa03040 Spliceosome 3/525 147/8135 0.9968 0.9993 0.8435 HSPA1A/HSPA2/SLU7 3 KEGG hsa04742 Taste transduction 1/525 86/8135 0.9969 0.9993 0.8435 GABBR2 1 KEGG hsa05322 Systemic lupus erythematosus 2/525 136/8135 0.9989 0.9993 0.8435 C3/CD86 2 KEGG hsa03008 Ribosome biogenesis in eukaryotes 1/525 109/8135 0.9993 0.9993 0.8435 XRN2 1