ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05168	Herpes simplex virus 1 infection	217/2017	495/8135	9.312e-22	3.11e-19	2.95e-19	ZNF426/ZNF543/ZNF550/ZNF436/ZNF619/ZNF182/ZNF155/ZNF764/RNASEL/ZNF565/ZNF189/ZNF235/ZNF417/AKT2/ZNF17/ZNF333/ZNF841/ZNF549/IKBKB/ZNF20/ZNF623/ZNF420/ZNF317/ZNF597/ZNF441/TNF/EIF2B1/ZNF286A/ZNF763/SRSF5/ZNF749/ZNF283/ZNF221/IKBKE/ZNF398/ZNF570/ZNF224/ZNF416/ZNF658/TNFRSF14/ZNF140/ZNF44/ZFP30/ZNF772/NXF1/ZNF793/ZNF490/ZNF676/ZNF674/EIF2B4/ZNF528/ZFP14/BAK1/ZNF350/ZNF620/ZNF551/ZSCAN32/ZNF589/TAB1/OAS2/ZNF583/ZNF547/ZNF823/ZNF2/ZNF555/ZNF611/TSC1/BAD/PILRB/C3/ZNF573/ZNF616/ZNF3/ZNF45/ZNF432/ZNF79/ZNF621/ZNF778/ZNF559/ZNF773/ZNF791/ZNF563/ZNF30/ZNF700/ZNF792/ZNF26/ZNF557/ZNF585B/ZNF721/ZNF564/ZNF846/ZNF613/ZNF226/ZNF57/IRF7/ZIK1/ZNF443/ZNF766/EIF2B3/OAS3/ZNF780A/ZNF780B/ZNF679/ZNF527/ZNF699/STAT2/CHUK/ZNF223/ZNF701/EIF4EBP1/POU2F2/ZNF614/OAS1/ZNF304/ZNF285/ZNF688/PILRA/ZNF665/FASLG/ZNF418/ZNF689/ZNF540/ZNF584/SRSF7/ZNF546/ZNF529/ZNF93/ZNF641/ZNF624/ZNF225/ZNF439/ZNF132/ZNF205/ZNF454/ZNF175/ZNF34/ZNF200/SRSF6/MAVS/ZNF300/ZNF568/ZNF77/ZNF566/ZNF222/PIK3R3/IRF3/RBAK/ZNF713/PML/ZNF284/ZNF607/ZNF473/ZNF571/ZNF8/ZNF600/IFNA21/EIF2AK1/ZFP82/ZNF442/ZNF585A/EIF2B5/PPP1CB/TP53/ZNF558/ZNF669/ITGA5/SRSF2/TICAM1/RELA/ZNF567/ZNF785/ZNF786/ZNF343/ZNF136/ZNF14/ZNF7/SRSF3/CASP8/ZNF85/ZNF615/ZNF587/ZNF677/ZNF879/ZFP69/ZNF836/ZNF425/EIF2B2/ZNF707/ZNF10/ZNF777/ZNF845/IFNA10/SRSF4/ZNF141/IFNA5/ZNF256/ZNF354B/TRAF6/ZNF569/ZNF717/ZNF799/ZNF718/IFIH1/ZNF714/IFNA2/ZNF234/ZNF184/HCFC2/DDX58/TAP1/TRAF5/ZNF606/CASP3/ZNF160/ZNF181/SRSF1/AKT1	217
KEGG	hsa03015	mRNA surveillance pathway	38/2017	97/8135	0.001157	0.1313	0.1246	CPSF7/NUDT21/PAPOLA/EIF4A3/PABPC3/PPP2R2D/NXF1/WDR82/CLP1/DDX39B/FUS/PELO/WDR33/GSPT1/UPF1/SMG6/PPP2R5D/RNGTT/RBM8A/CSTF1/PABPC1L2A/PABPN1/UPF2/SYMPK/SMG7/DAZAP1/PPP1CB/SMG5/CSTF3/PPP2R2A/CSTF2/CPSF3/ACIN1/GLE1/PPP2R5A/PNN/PPP2R3B/PPP2R2C	38
KEGG	hsa05223	Non-small cell lung cancer	30/2017	72/8135	0.001179	0.1313	0.1246	AKT2/BAK1/STAT5A/FHIT/BAD/PLCG1/ARAF/KIF5B/RB1/SOS2/CCND1/JAK3/PIK3R3/PDPK1/RASSF5/ERBB2/TP53/GADD45G/GADD45A/CDKN2A/HRAS/HGF/FOXO3/RXRB/KRAS/GRB2/E2F2/KIF5A/AKT1/CDKN1A	30
KEGG	hsa05213	Endometrial cancer	25/2017	58/8135	0.001674	0.1398	0.1326	AKT2/BAK1/BAD/CTNNB1/ARAF/SOS2/CCND1/PIK3R3/APC2/PDPK1/ERBB2/TP53/TCF7L2/GADD45G/GADD45A/HRAS/TCF7/FOXO3/KRAS/GRB2/MYC/CDH1/CTNNA2/AKT1/CDKN1A	25
KEGG	hsa05160	Hepatitis C	55/2017	157/8135	0.002442	0.1631	0.1547	RNASEL/AKT2/IKBKB/TNF/PPP2R2D/IKBKE/EIF3E/BAK1/OAS2/BAD/CTNNB1/ARAF/YWHAZ/CD81/IRF7/OAS3/STAT2/CHUK/IFIT1/OAS1/MX1/RB1/FASLG/SOS2/CCND1/MAVS/PIK3R3/IRF3/IFNA21/EIF2AK1/CLDN24/RSAD2/CLDN10/TP53/CLDN15/TICAM1/MX2/RELA/CASP8/HRAS/PPP2R2A/KRAS/IFNA10/IFNA5/TRAF6/GRB2/PSME3/IFNA2/MYC/DDX58/E2F2/CASP3/PPP2R2C/AKT1/CDKN1A	55
KEGG	hsa05165	Human papillomavirus infection	104/2017	331/8135	0.003205	0.1713	0.1625	TADA3/AKT2/IKBKB/PTGER4/TNF/PPP2R2D/CHAD/IKBKE/BCAP31/LFNG/BAK1/TCIRG1/TSC1/BAD/CTNNB1/COL4A4/CCND2/HES7/DVL3/MFNG/CSNK1A1L/COL9A3/STAT2/CHUK/EIF4EBP1/FZD9/MX1/RB1/PPP2R5D/ATP6V1C2/FASLG/COL4A3/FZD7/DVL2/COL9A1/RBPJ/SOS2/HES6/COL6A1/ATP6V1B1/ITGB8/ITGA10/CCND1/HES1/COL4A1/PIK3R3/IRF3/HES3/APC2/LAMB1/HDAC1/MDM2/COL4A2/FN1/IFNA21/WNT4/COL4A5/TP53/CHD4/WNT11/ITGA5/TCF7L2/TICAM1/MX2/RELA/COL6A2/ATP6V1G3/ATP6V0B/WNT9B/THBS1/COL9A2/CASP8/CRB3/NFX1/HRAS/TCF7/PPP2R2A/LAMA5/KRAS/IFNA10/CREB3L1/PXN/ITGAV/IFNA5/PSMC1/FZD6/WNT7B/GRB2/WNT2/PPP2R5A/SLC9A3R1/COL2A1/IFNA2/COL1A2/CCNE1/OASL/CASP3/ATP6V0E2/MAGI1/PPP2R3B/PPP2R2C/AKT1/CDKN1A/LAMA3	104
KEGG	hsa05216	Thyroid cancer	17/2017	37/8135	0.004057	0.1713	0.1625	BAK1/CTNNB1/CCND1/TPM3/TP53/TCF7L2/GADD45G/GADD45A/HRAS/TCF7/RXRB/KRAS/MYC/NCOA4/TPR/CDH1/CDKN1A	17
KEGG	hsa00600	Sphingolipid metabolism	22/2017	52/8135	0.004103	0.1713	0.1625	CERS5/ARSA/SMPD2/SMPD4/KDSR/PSAP/SPTLC1/SGMS1/SGPP2/NEU2/SMPD1/NEU4/SPTLC3/CERS4/GLA/SGPL1/B4GALT6/GBA2/DEGS1/SGPP1/CERS3/NEU3	22
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	13/2017	26/8135	0.004766	0.1769	0.1678	PIGV/PIGG/PIGM/GPAA1/PGAP1/PIGX/PIGW/PIGC/PIGS/PIGH/MPPE1/PIGO/PIGP	13
KEGG	hsa04622	RIG-I-like receptor signaling pathway	27/2017	70/8135	0.007231	0.2198	0.2085	IKBKB/TNF/IKBKE/CASP10/DHX58/IRF7/CHUK/PIN1/MAPK12/MAVS/IRF3/DDX3X/NFKBIB/IFNA21/RNF125/SIKE1/TANK/RELA/MAPK11/CASP8/IFNA10/IFNA5/TRAF6/IFIH1/IFNA2/MAP3K1/DDX58	27
KEGG	hsa05132	Salmonella infection	79/2017	249/8135	0.00724	0.2198	0.2085	RIPK3/RAB7A/TUBA3C/AKT2/TIRAP/IKBKB/SNX18/ACTR10/TNF/ABI1/DCTN1/PFN3/MYL7/S100A10/MYL12B/BAK1/VPS39/TAB1/CYTH1/CTNNB1/MYL2/FOS/FHOD1/CYTH2/TNFRSF10B/ELMO2/EXOC5/DYNC2LI1/CHUK/KIF5B/AHNAK/TNFRSF10A/ARL8B/DCTN6/PODXL/DYNLRB1/MAPK12/RAB9B/CYTH4/DYNLL1/DYNC1H1/ARPC1B/DCTN5/KLC3/KPNA1/PLEKHM2/RILP/TCF7L2/RELA/BRK1/JUN/MAPK11/DCTN2/RALA/CASP8/ACTR3C/RAB5C/TUBA3E/HRAS/KPNA4/TCF7/DYNC1I1/TAB3/CASP5/ARF1/PIK3C2A/TRAF6/HSP90AB1/NOD1/ARHGEF26/KLC4/MYC/DYNLT1/DNM2/CASP3/TXN2/PLEKHM1/KIF5A/AKT1	79
KEGG	hsa04932	Non-alcoholic fatty liver disease	52/2017	155/8135	0.008412	0.2341	0.2221	PRKAB1/AKT2/IKBKB/COX6C/TNF/NDUFS3/COX5B/NDUFB10/COX6A2/NDUFA9/COX1/FOS/IL6R/MAP3K11/COX6B1/FASLG/LEP/UQCRC2/MAPK12/PRKAG1/PIK3R3/PRKAB2/NDUFB3/NDUFAB1/UQCRFS1/ADIPOR1/NDUFS5/RELA/JUN/MAPK11/COX2/NDUFA12/NDUFV2/NDUFA2/NDUFB11/CASP8/INS/NDUFB5/NDUFB4/ADIPOR2/NDUFA3/CYTB/MLX/PRKAA2/NDUFB6/NDUFA6/IRS1/MLXIPL/COX4I2/CASP3/COX4I1/AKT1	52
KEGG	hsa05162	Measles	47/2017	139/8135	0.01012	0.26	0.2467	AKT2/IKBKB/IKBKE/IL2RB/BAK1/STAT5A/OAS2/BAD/CCND2/FOS/IRF7/OAS3/STAT2/CHUK/OAS1/MX1/BBC3/FASLG/CCND1/RAB9B/MAVS/JAK3/PIK3R3/IRF3/MSN/NFKBIB/IFNA21/EIF2AK1/TP53/HSPA1L/MX2/RELA/JUN/CASP8/HSPA2/SLAMF1/IFNA10/CD28/IFNA5/TRAF6/IFIH1/IFNA2/CCNE1/DDX58/CD3E/CASP3/AKT1	47
KEGG	hsa05222	Small cell lung cancer	33/2017	92/8135	0.0113	0.2617	0.2483	AKT2/IKBKB/BAK1/FHIT/COL4A4/CKS1B/CHUK/RB1/COL4A3/CCND1/TRAF1/COL4A1/PIK3R3/LAMB1/COL4A2/FN1/COL4A5/TP53/RELA/GADD45G/GADD45A/RXRB/LAMA5/ITGAV/TRAF6/CCNE1/MYC/E2F2/TRAF5/CASP3/AKT1/CDKN1A/LAMA3	33
KEGG	hsa05225	Hepatocellular carcinoma	55/2017	168/8135	0.01175	0.2617	0.2483	SMAD4/AKT2/SMARCB1/BAK1/BAD/CTNNB1/PLCG1/ARAF/TXNRD2/DVL3/CSNK1A1L/FZD9/GSTA2/RB1/FZD7/DVL2/SOS2/ARID2/CCND1/GSTA4/PIK3R3/APC2/DPF3/WNT4/SHC1/TP53/WNT11/MGST1/SMARCA2/TCF7L2/DPF1/WNT9B/LRP6/GADD45G/GAB1/GADD45A/CDKN2A/PBRM1/HRAS/TCF7/HGF/KRAS/ARID1A/SMARCD1/FZD6/WNT7B/GRB2/WNT2/HMOX1/MGST3/MYC/E2F2/SMARCD2/AKT1/CDKN1A	55
KEGG	hsa05217	Basal cell carcinoma	24/2017	63/8135	0.01298	0.2709	0.257	SUFU/BAK1/CTNNB1/DVL3/FZD9/FZD7/DVL2/APC2/WNT4/TP53/WNT11/TCF7L2/WNT9B/GADD45G/GADD45A/TCF7/GLI2/FZD6/WNT7B/KIF7/WNT2/BMP2/SMO/CDKN1A	24
KEGG	hsa03013	Nucleocytoplasmic transport	37/2017	108/8135	0.01683	0.3307	0.3137	EIF4A3/SUMO2/NXF1/RAE1/NUP160/SUMO1/RANGAP1/EEF1A1/DDX39B/IPO13/NUP107/UBE2I/EEF1A2/NUP188/UPF1/SNUPN/SUMO4/NUP93/RBM8A/IPO4/KPNA1/PHAX/UPF2/NUP85/XPO7/THOC3/IPO8/NUP133/KPNA4/ACIN1/THOC5/GLE1/KPNA7/THOC2/TPR/AAAS/PNN	37
KEGG	hsa05161	Hepatitis B	52/2017	162/8135	0.02065	0.373	0.3539	SMAD4/AKT2/TIRAP/IKBKB/TNF/IKBKE/STAT5A/ATF6B/CASP10/TAB1/BAD/FOS/ARAF/YWHAZ/IRF7/STAT2/CHUK/RB1/FASLG/SOS2/MAPK12/MAVS/JAK3/PIK3R3/IRF3/DDX3X/IFNA21/NFATC1/TP53/TICAM1/RELA/JUN/MAPK11/CASP8/HRAS/KRAS/IFNA10/CREB3L1/IFNA5/EGR2/TRAF6/GRB2/IFIH1/IFNA2/CCNE1/MYC/MAP3K1/DDX58/E2F2/CASP3/AKT1/CDKN1A	52
KEGG	hsa04974	Protein digestion and absorption	35/2017	103/8135	0.02234	0.373	0.3539	CTRL/COL5A3/COL5A1/KCNJ13/COL27A1/COL22A1/COL4A4/COL9A3/COL4A3/COL9A1/COL13A1/COL6A1/COL23A1/COL8A2/PGA3/COL4A1/COL11A1/COL4A2/COL14A1/SLC8A2/COL4A5/ELN/COL16A1/COL18A1/COL6A2/COL9A2/COL12A1/COL20A1/ATP1A1/SLC1A5/COL2A1/COL1A2/SLC6A19/COL7A1/KCNN4	35
KEGG	hsa05210	Colorectal cancer	30/2017	86/8135	0.02282	0.373	0.3539	SMAD4/AKT2/BAK1/BAD/CTNNB1/FOS/ARAF/BBC3/SOS2/CCND1/PIK3R3/APC2/TP53/TCF7L2/JUN/RALA/GADD45G/GADD45A/HRAS/TCF7/RAC2/KRAS/MSH2/AREG/APPL1/GRB2/MYC/CASP3/AKT1/CDKN1A	30
KEGG	hsa05220	Chronic myeloid leukemia	27/2017	76/8135	0.02345	0.373	0.3539	SMAD4/AKT2/IKBKB/BAK1/STAT5A/BAD/ARAF/CHUK/RB1/SOS2/CCND1/PIK3R3/HDAC1/MDM2/SHC1/TP53/RELA/GADD45G/GADD45A/CDKN2A/HRAS/KRAS/GRB2/MYC/E2F2/AKT1/CDKN1A	27
KEGG	hsa00562	Inositol phosphate metabolism	26/2017	73/8135	0.02502	0.3799	0.3604	MTMR7/PIP4K2B/IPPK/IMPA1/INPP5E/PLCG1/MTMR4/MTMR1/PLCB2/PLCD4/PIP4K2C/ISYNA1/PI4K2B/PIP5K1A/FIG4/INPP5J/TPI1/SYNJ2/INPP5F/PI4KB/ITPKB/INPP5B/PIK3C2A/MIOX/INPP4A/PLCE1	26
KEGG	hsa05221	Acute myeloid leukemia	24/2017	67/8135	0.02848	0.4136	0.3923	AKT2/IKBKB/STAT5A/BAD/ARAF/CHUK/EIF4EBP1/DUSP6/PIM2/SOS2/CCND1/PIK3R3/RARA/CSF1R/PML/TCF7L2/RELA/PPARD/HRAS/TCF7/KRAS/GRB2/MYC/AKT1	24
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/2017	11/8135	0.03293	0.4316	0.4094	COQ3/COQ6/COQ7/COQ2/GGCX/COQ5	6
KEGG	hsa04714	Thermogenesis	70/2017	232/8135	0.03427	0.4316	0.4094	ND6/PRKAB1/COX15/COX6C/SMARCB1/NDUFS3/COX5B/NDUFB10/SLC25A20/NDUFAF1/COX6A2/NDUFA9/TSC1/CPT1A/COX1/ND5/NDUFAF4/COX6B1/COA1/PRDM16/COX17/ADCY7/SOS2/UQCRC2/MAPK12/PRKAG1/PRKAB2/NDUFB3/NDUFAB1/DPF3/COA5/UQCRFS1/NDUFS5/ND4/COX18/SMARCA2/DPF1/ND1/MAPK11/COX2/NDUFA12/NDUFV2/NDUFAF3/NDUFA2/NDUFB11/BMP8A/NDUFB5/HRAS/ND2/NDUFB4/COX14/NDUFA3/COX10/KRAS/ARID1A/CYTB/CREB3L1/SMARCD1/ADCY4/NPPB/CPT2/GRB2/PRKAA2/NDUFB6/NDUFAF6/NDUFA6/COX4I2/UCP1/COX4I1/SMARCD2	70
KEGG	hsa05226	Gastric cancer	47/2017	149/8135	0.03605	0.4316	0.4094	SMAD4/AKT2/BAK1/CTNNB1/ARAF/DVL3/CSNK1A1L/FZD9/RB1/FZD7/DVL2/FGF3/SOS2/CCND1/FGF6/PIK3R3/APC2/WNT4/ERBB2/SHC1/TP53/WNT11/TCF7L2/WNT9B/LRP6/GADD45G/GAB1/GADD45A/HRAS/TCF7/FGF1/HGF/RXRB/KRAS/FZD6/WNT7B/GRB2/WNT2/ABCB1/CCNE1/MYC/E2F2/CDH1/CTNNA2/FGF4/AKT1/CDKN1A	47
KEGG	hsa04936	Alcoholic liver disease	45/2017	142/8135	0.03672	0.4316	0.4094	PRKAB1/AKT2/TIRAP/IKBKB/TRA2A/TNF/IKBKE/TAB1/C3/CPT1A/CTNNB1/MLYCD/ACOX3/MAP3K14/CHUK/FASLG/SIRT1/MAPK12/CCND1/PRKAG1/IRF3/PRKAB2/ADIPOR1/ACADVL/IFNA21/TCF7L2/TICAM1/RELA/MAPK11/CASP8/LPIN1/C1QC/IL17A/TCF7/ADIPOR2/FOXO3/TAB3/IFNA10/IFNA5/LPIN3/TRAF6/IFNA2/PRKAA2/CASP3/AKT1	45
KEGG	hsa05218	Melanoma	25/2017	72/8135	0.03756	0.4316	0.4094	AKT2/BAK1/BAD/IGF1/ARAF/RB1/FGF3/CCND1/FGF6/PIK3R3/MDM2/TP53/GADD45G/GADD45A/CDKN2A/PDGFC/HRAS/FGF1/HGF/KRAS/E2F2/CDH1/FGF4/AKT1/CDKN1A	25
KEGG	hsa03430	Mismatch repair	10/2017	23/8135	0.03847	0.4316	0.4094	MLH3/RFC1/POLD2/RPA2/EXO1/POLD3/MSH2/POLD4/RFC3/RFC5	10
KEGG	hsa00670	One carbon pool by folate	9/2017	20/8135	0.03876	0.4316	0.4094	MTR/FTCD/TYMS/MTHFR/MTHFD2/MTHFD1/SHMT1/MTFMT/ATIC	9
KEGG	hsa03030	DNA replication	14/2017	36/8135	0.04294	0.4627	0.4389	POLE4/RFC1/POLD2/POLA2/FEN1/RNASEH2C/RPA2/PRIM1/MCM5/POLD3/MCM2/POLD4/RFC3/RFC5	14
KEGG	hsa04071	Sphingolipid signaling pathway	38/2017	119/8135	0.04637	0.4811	0.4564	CERS5/AKT2/TNF/PPP2R2D/GNAI2/SMPD2/PLCB2/PPP2R5D/FYN/MS4A2/PLD2/SPTLC1/SGMS1/SGPP2/GNAQ/MAPK12/SMPD1/PIK3R3/PDPK1/SPTLC3/CERS4/TP53/RELA/MAPK11/SGPL1/S1PR1/HRAS/RAC2/PPP2R2A/KRAS/DEGS1/PPP2R5A/SGPP1/FCER1A/CERS3/PPP2R3B/PPP2R2C/AKT1	38
KEGG	hsa01523	Antifolate resistance	12/2017	30/8135	0.04753	0.4811	0.4564	SLC46A1/IKBKB/TNF/ABCC2/CHUK/FPGS/TYMS/MTHFR/RELA/SHMT1/ATIC/FOLR3	12
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	66/2017	223/8135	0.05617	0.5024	0.4766	ND6/AKR1C3/AKT2/IKBKB/COX6C/NDUFS3/COX5B/NDUFB10/COX6A2/NDUFA9/BAD/COX1/SLC25A4/FOS/ND5/ARAF/MAP3K14/CHUK/COX6B1/GSTA2/PLD2/SOS2/UQCRC2/MAPK12/GSTA4/PIK3R3/NDUFB3/PDPK1/NDUFAB1/UQCRFS1/NDUFS5/ND4/PRKD2/MGST1/ND1/HIF1A/RELA/JUN/CBR1/MAPK11/COX2/AHR/NDUFA12/NDUFV2/NDUFA2/NDUFB11/NDUFB5/HRAS/ND2/NDUFB4/SLC26A2/NDUFA3/HGF/FOXO3/AS3MT/KRAS/CYTB/GRB2/HMOX1/MGST3/AKR1A1/NDUFB6/NDUFA6/COX4I2/COX4I1/AKT1	66
KEGG	hsa05205	Proteoglycans in cancer	61/2017	205/8135	0.05857	0.5024	0.4766	AKT2/TNF/RRAS2/MRAS/TWIST1/CAV1/ARHGEF1/IHH/IGF1/CTNNB1/PLCG1/ARAF/TFAP4/FZD9/VAV1/FASLG/FZD7/SOS2/MAPK12/CCND1/TIAM1/PPP1R12A/PIK3R3/SDC1/PDPK1/MSN/PTPN6/MDM2/FN1/WNT4/ERBB2/PPP1CB/TP53/WNT11/ITGA5/HIF1A/PPP1R12C/GPC1/MAPK11/WNT9B/THBS1/GAB1/HRAS/HGF/KRAS/PXN/ITGAV/FZD6/WNT7B/GRB2/ANK1/WNT2/DDX5/COL1A2/MYC/CASP3/ANK3/SMO/AKT1/CDKN1A/PLCE1	61
KEGG	hsa04211	Longevity regulating pathway	29/2017	89/8135	0.05914	0.5024	0.4766	PRKAB1/ATG101/AKT2/ATF6B/TSC1/IGF1/EHMT2/EIF4EBP1/EIF4E2/ADCY7/SIRT1/PRKAG1/PIK3R3/PRKAB2/ADIPOR1/TP53/RELA/INS/HRAS/ADIPOR2/FOXO3/KRAS/CREB3L1/APPL1/ADCY4/SESN1/PRKAA2/IRS1/AKT1	29
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/2017	143/8135	0.06039	0.5024	0.4766	PCGF1/SMAD4/AKT2/SETDB1/KLF4/ID3/IGF1/CTNNB1/DVL3/POU5F1/FZD9/ONECUT1/FZD7/DVL2/MAPK12/JAK3/INHBE/PIK3R3/APC2/ID2/WNT4/DUSP9/ACVR1C/IL6ST/WNT11/REST/ISL1/MAPK11/PCGF5/WNT9B/HRAS/TCF7/PCGF2/SMAD9/KRAS/FZD6/WNT7B/GRB2/HOXA1/WNT2/ACVR2B/MYC/PCGF3/AKT1	44
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/2017	100/8135	0.06187	0.5024	0.4766	SMAD4/AKT2/TNF/EGR1/STAT5A/COL4A4/PLCG1/PLCB2/PLCD4/AGTR1/COL4A3/MAPK12/CCND1/COL4A1/PIK3R3/COL4A2/FN1/NFATC1/COL4A5/RELA/JUN/MAPK11/F3/AGER/HRAS/VEGFC/KRAS/COL1A2/DIAPH1/CASP3/AKT1/PLCE1	32
KEGG	hsa04210	Apoptosis	42/2017	136/8135	0.06204	0.5024	0.4766	TUBA3C/AKT2/IKBKB/DFFA/TNF/BAK1/DIABLO/CASP10/BAD/AIFM1/FOS/TNFRSF10B/MAP3K14/CHUK/BBC3/FASLG/TNFRSF10A/DFFB/CTSW/TRAF1/CTSC/PIK3R3/PDPK1/CASP6/TP53/PARP4/SPTA1/RELA/HRK/JUN/PIDD1/CASP8/GADD45G/GADD45A/TUBA3E/HRAS/KRAS/PRF1/MCL1/SPTAN1/CASP3/AKT1	42
KEGG	hsa03040	Spliceosome	45/2017	147/8135	0.06264	0.5024	0.4766	PHF5A/SMNDC1/CHERP/EIF4A3/TRA2A/RNU5A-1/SRSF5/U2AF2/DHX16/SF3B3/SF3B2/DDX39B/FUS/USP39/DDX23/PRPF18/PRPF38A/PRPF4/SRSF7/SF3B6/LSM5/RBM8A/SNRPD3/SRSF6/DHX8/BUD31/LSM3/SF3B1/DDX42/HSPA1L/SRSF2/THOC3/TXNL4A/SRSF3/SNRPB/HSPA2/SRSF4/ACIN1/DDX5/SART1/CCDC12/PRPF38B/THOC2/PRPF31/SRSF1	45
KEGG	hsa05224	Breast cancer	45/2017	147/8135	0.06264	0.5024	0.4766	AKT2/BAK1/IGF1/CTNNB1/FOS/ARAF/SP1/DVL3/CSNK1A1L/FZD9/RB1/FZD7/DVL2/FGF3/SOS2/CCND1/HES1/FGF6/PIK3R3/APC2/WNT4/ERBB2/SHC1/TP53/WNT11/TCF7L2/JUN/WNT9B/LRP6/NFKB2/GADD45G/GADD45A/HRAS/TCF7/FGF1/KRAS/FZD6/WNT7B/GRB2/WNT2/MYC/E2F2/FGF4/AKT1/CDKN1A	45
KEGG	hsa04625	C-type lectin receptor signaling pathway	33/2017	104/8135	0.06515	0.5024	0.4766	AKT2/IKBKB/TNF/IL23A/IKBKE/RRAS2/MRAS/MAP3K14/STAT2/CHUK/CALML5/MAPK12/CCL17/LSP1/PIK3R3/MDM2/NFATC1/RELA/JUN/MAPK11/IL10/NFKB2/IL17D/PPP3CA/CASP8/HRAS/KSR1/KRAS/EGR2/CLEC6A/PPP3R1/CALML3/AKT1	33
KEGG	hsa04070	Phosphatidylinositol signaling system	31/2017	97/8135	0.06631	0.5024	0.4766	IP6K2/MTMR7/PIP4K2B/IPPK/IMPA1/INPP5E/PLCG1/MTMR4/MTMR1/PLCB2/PLCD4/PIP4K2C/CALML5/PIK3R3/IP6K1/DGKA/PI4K2B/DGKZ/DGKK/PIP5K1A/SYNJ2/INPP5F/PI4KB/ITPKB/INPP5B/PIK3C2A/CALML3/PPIP5K2/PPIP5K1/INPP4A/PLCE1	31
KEGG	hsa00900	Terpenoid backbone biosynthesis	9/2017	22/8135	0.07103	0.5024	0.4766	FNTA/ICMT/RCE1/PCYOX1/NUS1/PMVK/HMGCR/DHDDS/GGPS1	9
KEGG	hsa04310	Wnt signaling pathway	50/2017	167/8135	0.07342	0.5024	0.4766	SMAD4/RYK/CTNNB1/CCND2/DVL3/CSNK1A1L/NOTUM/PLCB2/FZD9/PRICKLE1/FZD7/DVL2/BTRC/RBX1/CCND1/DKK2/NKD2/APC2/RUVBL1/CBY1/FOSL1/NFATC1/WNT4/SIAH1/SOX17/TP53/WNT11/TCF7L2/PRICKLE3/JUN/PPARD/WNT9B/LRP6/FBXW11/PPP3CA/VANGL2/TCF7/CTNNBIP1/PORCN/RAC2/LGR6/CHD8/FZD6/WNT7B/WNT2/SFRP5/SFRP2/PPP3R1/MYC/RSPO1	50
KEGG	hsa04150	mTOR signaling pathway	47/2017	156/8135	0.07366	0.5024	0.4766	AKT2/IKBKB/TNF/TSC1/IGF1/RRAGB/FLCN/DVL3/CHUK/EIF4EBP1/EIF4E2/FZD9/ATP6V1C2/FZD7/DVL2/ULK2/SOS2/ATP6V1B1/WDR59/PRR5L/PIK3R3/PDPK1/STRADA/TTI1/WNT4/WNT11/STRADB/ATP6V1G3/WNT9B/FNIP2/LRP6/MAPKAP1/INS/LPIN1/HRAS/SLC7A5/KRAS/SGK1/FZD6/WNT7B/LPIN3/GRB2/WNT2/LAMTOR2/PRKAA2/IRS1/AKT1	47
KEGG	hsa04218	Cellular senescence	47/2017	156/8135	0.07366	0.5024	0.4766	AKT2/LIN37/RRAS2/MRAS/PPID/TSC1/RAD9A/CCND2/SLC25A4/MYBL2/EIF4EBP1/RB1/ZFP36L1/FOXM1/CALML5/SIRT1/BTRC/MAPK12/CCND1/GATA4/PIK3R3/MDM2/RASSF5/NFATC1/PPP1CB/TP53/CHEK1/RELA/MAPK11/ZFP36L2/FBXW11/PPP3CA/GADD45G/GADD45A/HUS1/CDKN2A/HRAS/FOXO3/KRAS/RAD1/CCNE1/PPP3R1/MYC/CALML3/E2F2/AKT1/CDKN1A	47
KEGG	hsa01524	Platinum drug resistance	24/2017	73/8135	0.0737	0.5024	0.4766	AKT2/ABCC2/BAK1/BAD/GSTA2/BBC3/FASLG/GSTA4/PIK3R3/PDPK1/MDM2/ERBB2/POLH/TP53/MGST1/CASP8/TOP2A/CDKN2A/ATP7A/MSH2/MGST3/CASP3/AKT1/CDKN1A	24
KEGG	hsa04115	p53 signaling pathway	24/2017	73/8135	0.0737	0.5024	0.4766	IGF1/CCND2/TNFRSF10B/BBC3/TNFRSF10A/CCNG2/CCND1/MDM2/SIAH1/SHISA5/TP53/CHEK1/PIDD1/GORAB/THBS1/CASP8/GADD45G/GADD45A/CDKN2A/GTSE1/SESN1/CCNE1/CASP3/CDKN1A	24
KEGG	hsa03450	Non-homologous end-joining	6/2017	13/8135	0.07732	0.5165	0.4899	POLM/XRCC4/LIG4/NHEJ1/FEN1/DCLRE1C	6
KEGG	hsa04623	Cytosolic DNA-sensing pathway	21/2017	63/8135	0.07946	0.5204	0.4937	RIPK3/IKBKB/IKBKE/POLR2H/IRF7/CHUK/POLR3A/POLR1D/ZBP1/MAVS/IRF3/POLR1C/POLR2K/POLR3K/NFKBIB/IFNA21/RELA/IFNA10/IFNA5/IFNA2/DDX58	21
KEGG	hsa05014	Amyotrophic lateral sclerosis	102/2017	364/8135	0.08245	0.526	0.499	ND6/BECN1/ATG101/TUBA3C/COX6C/ACTR10/TNF/NDUFS3/DCTN1/COX5B/NDUFB10/PFN3/NXF1/ANXA7/RAE1/NUP160/COX6A2/NDUFA9/BAD/UBQLN1/FUS/COX1/ND5/PSMA1/NUP107/PSMC4/PSMA6/NUP188/COX6B1/KIF5B/NUP93/SRSF7/ULK2/PSMB6/ALS2/DCTN6/UQCRC2/MAPK12/GRIA2/DNAH1/NDUFB3/ATXN2L/NDUFAB1/SETX/UQCRFS1/PSMA5/AMBRA1/DCTN5/HNRNPA2B1/KLC3/NDUFS5/NUP85/RAB39B/ND4/TP53/TANK/ND1/FIG4/PSMA2/MAPK11/DCTN2/COX2/SRSF3/NDUFA12/NDUFV2/NDUFA2/NDUFB11/PPP3CA/UBQLN4/DNAL4/NUP133/TUBA3E/NDUFB5/GPX6/ND2/NDUFB4/DNAI1/NDUFA3/PSMD1/PSMD9/DERL1/CYTB/NRG2/HSPA5/PSMC1/VAPB/GLE1/NOS1/SLC1A2/NDUFB6/NEFM/PPP3R1/DNAH12/KLC4/NDUFA6/TPR/MAP1LC3C/COX4I2/CASP3/COX4I1/KIF5A/DNAH14	102
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	45/2017	150/8135	0.08346	0.526	0.499	AKT2/PPP2R2D/GNAI2/ATF6B/MYL2/CACNB1/PLCB2/PPP2R5D/AGTR1/ADCY7/CALML5/TPM4/MYH6/TNNT2/GNAQ/MAPK12/CACNA1C/MYL4/TPM3/PIK3R6/SLC8A2/PPP1CB/CACNG4/MAPK11/ADRA1D/CACNG7/PLN/ADRB2/PPP2R2A/ATP1A1/ATP2B2/CREB3L1/TNNI3/ADRA1B/PIK3R5/ADCY4/PPP2R5A/CALML3/ATP2B3/AGTR2/SCN4B/RAPGEF3/PPP2R3B/PPP2R2C/AKT1	45
KEGG	hsa03410	Base excision repair	12/2017	33/8135	0.09339	0.562	0.5332	OGG1/APEX2/POLE4/MPG/POLD2/HMGB1/FEN1/PARP4/NEIL1/POLD3/POLD4/NEIL3	12
KEGG	hsa04130	SNARE interactions in vesicular transport	12/2017	33/8135	0.09339	0.562	0.5332	VAMP7/BET1/STX17/VAMP1/STX5/YKT6/STX1B/STX4/STX6/BET1L/GOSR1/STX11	12
KEGG	hsa04146	Peroxisome	26/2017	82/8135	0.09423	0.562	0.5332	PEX12/PEX11B/PRDX1/PEX19/PEX5/PEX26/MLYCD/ACOX3/SLC25A17/PEX11G/PMVK/SCP2/ABCD4/NUDT7/PEX14/HMGCL/PRDX5/GSTK1/PEX7/PEX1/PEX13/PXMP4/AGXT/EHHADH/ECI2/PEX5L	26
KEGG	hsa04660	T cell receptor signaling pathway	32/2017	104/8135	0.0977	0.5646	0.5356	AKT2/IKBKB/TNF/FOS/PLCG1/MAP3K14/CHUK/VAV1/FYN/IL4/SOS2/MAPK12/PIK3R3/PDPK1/NFKBIB/PTPN6/NFATC1/MAP3K8/RELA/JUN/MAPK11/IL10/PPP3CA/HRAS/LCP2/KRAS/CD28/GRB2/PPP3R1/CD3E/GRAP2/AKT1	32
KEGG	hsa03420	Nucleotide excision repair	16/2017	47/8135	0.0989	0.5646	0.5356	GTF2H4/POLE4/RFC1/XPC/POLD2/RBX1/CETN2/RPA2/POLD3/ERCC2/CDK7/POLD4/RFC3/ERCC3/GTF2H5/RFC5	16
KEGG	hsa00020	Citrate cycle (TCA cycle)	11/2017	30/8135	0.1004	0.5646	0.5356	DLST/ACLY/CS/PDHA2/DLAT/SUCLG1/OGDH/IDH3B/ACO1/MDH2/PCK2	11
KEGG	hsa04510	Focal adhesion	58/2017	201/8135	0.1037	0.5646	0.5356	AKT2/CHAD/MYL7/RAP1A/MYL12B/CAV1/BAD/IGF1/CTNNB1/COL4A4/CCND2/MYL2/COL9A3/VAV1/RAP1B/FYN/COL4A3/COL9A1/SOS2/COL6A1/ITGB8/ITGA10/CCND1/ZYX/COL4A1/PPP1R12A/PIK3R3/PDPK1/BCAR1/LAMB1/COL4A2/FN1/ERBB2/SHC1/COL4A5/PPP1CB/DOCK1/ITGA5/PIP5K1A/PPP1R12C/COL6A2/JUN/THBS1/COL9A2/PDGFC/HRAS/VEGFC/RAC2/HGF/LAMA5/PXN/ITGAV/GRB2/COL2A1/COL1A2/DIAPH1/AKT1/LAMA3	58
KEGG	hsa00190	Oxidative phosphorylation	40/2017	134/8135	0.1043	0.5646	0.5356	ND6/COX15/COX6C/NDUFS3/COX5B/NDUFB10/COX6A2/NDUFA9/TCIRG1/COX1/ND5/COX6B1/ATP6V1C2/COX17/UQCRC2/ATP6V1B1/NDUFB3/NDUFAB1/UQCRFS1/NDUFS5/ND4/ND1/ATP6V1G3/COX2/ATP6V0B/NDUFA12/NDUFV2/NDUFA2/NDUFB11/NDUFB5/ND2/NDUFB4/NDUFA3/COX10/CYTB/NDUFB6/NDUFA6/COX4I2/ATP6V0E2/COX4I1	40
KEGG	hsa01250	Biosynthesis of nucleotide sugars	13/2017	37/8135	0.1048	0.5646	0.5356	UGP2/GMDS/MPI/GALT/GNE/GMPPA/PMM2/PGM3/UAP1/NAGK/GFPT1/MIOX/GNPNAT1	13
KEGG	hsa04068	FoxO signaling pathway	39/2017	131/8135	0.1111	0.5647	0.5357	PRKAB1/SMAD4/AKT2/IKBKB/IGF1/CCND2/ARAF/CHUK/FASLG/SIRT1/CDKN2D/SOS2/CCNG2/HOMER2/MAPK12/CCND1/PRKAG1/HOMER3/PIK3R3/PRKAB2/PDPK1/MDM2/MAPK11/IL10/GADD45G/GADD45A/INS/S1PR1/HRAS/FOXO3/KRAS/SGK1/GRB2/PRKAA2/KLF2/IRS1/PCK2/AKT1/CDKN1A	39
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	39/2017	131/8135	0.1111	0.5647	0.5357	SH2D1B/TNF/CD48/PLCG1/ARAF/TNFRSF10B/NCR1/VAV1/FYN/FASLG/TNFRSF10A/SOS2/CD244/PIK3R3/PTPN6/NCR3/IFNA21/NFATC1/KIR2DS4/ULBP2/SH3BP2/SHC1/KLRD1/FCGR3A/PPP3CA/KIR2DS1/HRAS/LCP2/RAC2/KRAS/IFNA10/KIR2DS2/PRF1/IFNA5/GRB2/KIR3DL2/IFNA2/PPP3R1/CASP3	39
KEGG	hsa05169	Epstein-Barr virus infection	58/2017	202/8135	0.1116	0.5647	0.5357	AKT2/IKBKB/TNF/IKBKE/BAK1/TAB1/OAS2/CCND2/PSMC4/IRF7/OAS3/MAP3K14/STAT2/CHUK/OAS1/RB1/FCER2/RBPJ/MAPK12/CCND1/MAVS/JAK3/HES1/PIK3R3/IRF3/NFKBIB/HDAC1/MDM2/IFNA21/TP53/NEDD4/RELA/JUN/MAPK11/ENTPD1/NFKB2/CASP8/GADD45G/GADD45A/PSMD1/IFNA10/CD40/IFNA5/PSMC1/TRAF6/IFNA2/CCNE1/MYC/BTK/DDX58/TAP1/E2F2/CD3E/CR2/TRAF5/CASP3/AKT1/CDKN1A	58
KEGG	hsa05231	Choline metabolism in cancer	30/2017	98/8135	0.1119	0.5647	0.5357	AKT2/PCYT1A/SLC22A5/TSC1/FOS/PLCG1/SP1/EIF4EBP1/PLD2/GPCPD1/SOS2/PIK3R3/PDPK1/DGKA/DGKZ/DGKK/WASF2/PIP5K1A/PLA2G4D/HIF1A/JUN/SLC44A5/PDGFC/HRAS/RAC2/KRAS/SLC44A1/GRB2/SLC5A7/AKT1	30
KEGG	hsa04213	Longevity regulating pathway - multiple species	20/2017	62/8135	0.1133	0.5647	0.5357	PRKAB1/AKT2/IGF1/ADCY7/SIRT1/PRKAG1/PIK3R3/PRKAB2/HDAC1/HSPA1L/CRYAB/INS/HRAS/HSPA2/FOXO3/KRAS/ADCY4/PRKAA2/IRS1/AKT1	20
KEGG	hsa05219	Bladder cancer	14/2017	41/8135	0.1153	0.5665	0.5374	ARAF/RB1/CCND1/MDM2/ERBB2/TP53/THBS1/CDKN2A/HRAS/KRAS/MYC/E2F2/CDH1/CDKN1A	14
KEGG	hsa04141	Protein processing in endoplasmic reticulum	49/2017	171/8135	0.1379	0.6674	0.6331	FBXO2/UBE2G1/SAR1B/RNF185/STUB1/BCAP31/BAK1/ATF6B/UBQLN1/UBXN4/MOGS/TUSC3/MBTPS2/PDIA6/RBX1/OS9/STT3A/GANAB/ERP29/UBE2D4/FBXO6/EIF2AK1/SAR1A/HSPA1L/DNAJB12/AMFR/DNAJB11/YOD1/PREB/CRYAB/DERL3/TRAM1L1/UBQLN4/MAN1A1/SEC24C/DNAJC1/MAN1C1/SEL1L2/HSPA2/PPP1R15A/DERL1/LMAN2/HSPA5/UBXN6/HSP90AB1/UBE2J1/SVIP/SEC62/UBXN2A	49
KEGG	hsa04659	Th17 cell differentiation	32/2017	108/8135	0.1451	0.6837	0.6486	SMAD4/IKBKB/IL23A/IL2RB/IL21R/STAT5A/IL27RA/FOS/PLCG1/IL6R/IL4R/CHUK/IL4/MAPK12/JAK3/RARA/NFKBIB/NFATC1/FOXP3/IL6ST/HIF1A/RELA/JUN/MAPK11/AHR/PPP3CA/IL21/IL17A/RXRB/HSP90AB1/PPP3R1/CD3E	32
KEGG	hsa05215	Prostate cancer	29/2017	97/8135	0.1466	0.6837	0.6486	AKT2/IKBKB/BAD/IGF1/CTNNB1/ARAF/CHUK/RB1/SOS2/CCND1/PIK3R3/PDPK1/MDM2/ERBB2/TP53/TCF7L2/RELA/INS/PDGFC/HRAS/TCF7/KRAS/CREB3L1/GRB2/HSP90AB1/CCNE1/E2F2/AKT1/CDKN1A	29
KEGG	hsa05214	Glioma	23/2017	75/8135	0.1474	0.6837	0.6486	AKT2/BAK1/IGF1/PLCG1/ARAF/RB1/CALML5/SOS2/CCND1/PIK3R3/MDM2/SHC1/TP53/GADD45G/GADD45A/CDKN2A/HRAS/KRAS/GRB2/CALML3/E2F2/AKT1/CDKN1A	23
KEGG	hsa04664	Fc epsilon RI signaling pathway	21/2017	68/8135	0.1524	0.6972	0.6614	AKT2/TNF/PLCG1/VAV1/FYN/MS4A2/IL4/SOS2/MAPK12/PIK3R3/PDPK1/PLA2G4D/MAPK11/HRAS/LCP2/RAC2/KRAS/GRB2/FCER1A/BTK/AKT1	21
KEGG	hsa05010	Alzheimer disease	104/2017	384/8135	0.1577	0.6984	0.6625	ND6/SLC39A13/BECN1/ATG101/APH1A/TUBA3C/AKT2/IKBKB/COX6C/TNF/NDUFS3/CHRM3/COX5B/NDUFB10/PPID/COX6A2/CSF1/NDUFA9/BAD/RTN4/CTNNB1/COX1/SLC25A4/SLC39A7/ND5/PSMA1/ARAF/PSMC4/DVL3/CSNK1A1L/PSMA6/ADAM10/CHUK/COX6B1/PLCB2/KIF5B/FZD9/FZD7/DVL2/CALML5/NAE1/ULK2/PSMB6/GNAQ/UQCRC2/DKK2/SLC39A6/PIK3R3/CACNA1C/APC2/NDUFB3/NDUFAB1/UQCRFS1/PSMA5/AMBRA1/KLC3/SLC39A1/WNT4/CHRM5/NDUFS5/ND4/WNT11/ND1/RELA/PSMA2/COX2/APBB1/WNT9B/LRP6/NDUFA12/NDUFV2/NDUFA2/NDUFB11/PPP3CA/CASP8/INS/AGER/TUBA3E/NDUFB5/HRAS/ND2/NDUFB4/NDUFA3/PSMD1/PSMD9/KRAS/CYTB/PSMC1/FZD6/WNT7B/SNCA/WNT2/NOS1/NDUFB6/PPP3R1/KLC4/NDUFA6/IRS1/CALML3/COX4I2/CASP3/COX4I1/KIF5A/AKT1	104
KEGG	hsa04137	Mitophagy - animal	22/2017	72/8135	0.1584	0.6984	0.6625	RAB7A/BECN1/RRAS2/MRAS/NBR1/SP1/TAX1BP1/TBC1D17/FUNDC1/AMBRA1/TP53/HIF1A/RELA/JUN/UBB/USP15/HRAS/FOXO3/KRAS/MAP1LC3C/UBA52/MFN1	22
KEGG	hsa01522	Endocrine resistance	29/2017	98/8135	0.1611	0.6984	0.6625	AKT2/BAD/IGF1/FOS/ARAF/SP1/RB1/ADCY7/SOS2/MAPK12/CCND1/PIK3R3/BIK/MDM2/ERBB2/SHC1/TP53/CARM1/JUN/MAPK11/CDKN2C/CDKN2A/HRAS/KRAS/ADCY4/GRB2/E2F2/AKT1/CDKN1A	29
KEGG	hsa04630	JAK-STAT signaling pathway	46/2017	162/8135	0.1633	0.6984	0.6625	AKT2/SOCS4/PIAS3/IL23A/SOCS7/IL2RB/IL21R/STAT5A/IL27RA/CCND2/IL6R/GFAP/IL11RA/IL4R/STAT2/LEP/IL4/SOS2/CCND1/JAK3/PIK3R3/PTPN6/CRLF2/IFNA21/IL7/IL6ST/PTPN2/CISH/IL10/CSF3/IL17D/STAM/HRAS/IL21/IL20RA/IL5RA/IL10RB/IFNA10/IL22RA1/IFNA5/GRB2/MCL1/IFNA2/MYC/AKT1/CDKN1A	46
KEGG	hsa05212	Pancreatic cancer	23/2017	76/8135	0.1641	0.6984	0.6625	SMAD4/AKT2/IKBKB/BAK1/BAD/ARAF/CHUK/RB1/PLD2/CCND1/PIK3R3/ERBB2/TP53/RELA/RALA/GADD45G/GADD45A/CDKN2A/RAC2/KRAS/E2F2/AKT1/CDKN1A	23
KEGG	hsa04151	PI3K-Akt signaling pathway	96/2017	354/8135	0.1652	0.6984	0.6625	AKT2/EPHA2/IKBKB/PPP2R2D/CHAD/IL2RB/ATF6B/CSF1/TSC1/BAD/IGF1/COL4A4/CCND2/IL6R/YWHAZ/IL4R/COL9A3/CHUK/EIF4EBP1/EIF4E2/PPP2R5D/FASLG/COL4A3/FGF3/IL4/COL9A1/FLT3LG/SOS2/COL6A1/ITGB8/ITGA10/CCND1/JAK3/COL4A1/FGF6/PIK3R3/PDPK1/CSF1R/LAMB1/MDM2/COL4A2/FN1/PIK3R6/IFNA21/IL7/ERBB2/COL4A5/TP53/ITGA5/RELA/COL6A2/GNG7/THBS1/CSF3/COL9A2/EFNA2/INS/PDGFC/HRAS/LPAR2/VEGFC/PPP2R2A/FGF1/HGF/FOXO3/LAMA5/KRAS/SGK1/IFNA10/CREB3L1/TCL1A/AREG/ITGAV/IFNA5/PIK3R5/GRB2/HSP90AB1/MCL1/PPP2R5A/COL2A1/IFNA2/COL1A2/PRKAA2/CCNE1/NTF3/MYC/IRS1/CDC37/MAGI1/PCK2/PPP2R3B/PPP2R2C/FGF4/AKT1/CDKN1A/LAMA3	96
KEGG	hsa05211	Renal cell carcinoma	21/2017	69/8135	0.1704	0.7115	0.6749	AKT2/RAP1A/PRCC/BAD/ARAF/FLCN/RAP1B/CUL2/SOS2/RBX1/PIK3R3/EGLN2/HIF1A/JUN/GAB1/HRAS/HGF/KRAS/GRB2/AKT1/CDKN1A	21
KEGG	hsa05171	Coronavirus disease - COVID-19	64/2017	232/8135	0.1777	0.731	0.6934	RPL26/RPL19/IKBKB/TNF/IKBKE/RPL21/RPS8/RPL30/RPL36A-HNRNPH2/OAS2/C3/RPLP2/FOS/PLCG1/IL6R/OAS3/STAT2/CHUK/RPS13/OAS1/MX1/RPS15A/RSL24D1/AGTR1/RPL36AL/RPLP0/RPS24/MAPK12/MAVS/RPL10L/PIK3R3/IRF3/RPL6/NFKBIB/RPS27/IFNA21/RPL23A/IL6ST/RPL12/MX2/RELA/JUN/MAPK11/CSF3/RPS7/RPS19/RPS11/RPL27/C1QC/RPS4Y1/RPSA/IFNA10/RPL24/IFNA5/TRAF6/IFIH1/RPS18/F2/IFNA2/DDX58/C8G/RPL32/UBA52/RPL18A	64
KEGG	hsa04512	ECM-receptor interaction	26/2017	88/8135	0.1795	0.731	0.6934	CHAD/HMMR/COL4A4/COL9A3/COL4A3/COL9A1/COL6A1/ITGB8/ITGA10/COL4A1/SDC1/LAMB1/COL4A2/FN1/COL4A5/ITGA5/COL6A2/DAG1/THBS1/COL9A2/SV2B/LAMA5/ITGAV/COL2A1/COL1A2/LAMA3	26
KEGG	hsa00430	Taurine and hypotaurine metabolism	6/2017	16/8135	0.184	0.7406	0.7026	CSAD/GGT7/GGT5/FMO4/FMO3/GAD1	6
KEGG	hsa04917	Prolactin signaling pathway	21/2017	70/8135	0.1895	0.7535	0.7148	AKT2/SOCS4/SOCS7/STAT5A/CCND2/FOS/GALT/SOS2/MAPK12/CCND1/PIK3R3/SHC1/CISH/RELA/MAPK11/INS/HRAS/FOXO3/KRAS/GRB2/AKT1	21
KEGG	hsa03440	Homologous recombination	13/2017	41/8135	0.1962	0.7629	0.7237	PALB2/TOP3A/TOP3B/POLD2/RAD52/BABAM1/BRIP1/RPA2/POLD3/XRCC3/SYCP3/RAD51B/POLD4	13
KEGG	hsa03250	Viral life cycle - HIV-1	19/2017	63/8135	0.1975	0.7629	0.7237	CPSF7/NELFA/CHMP4A/SMARCB1/HGS/CDK9/MX1/ELL2/SERINC5/NELFCD/PIN1/APOBEC3F/MAP1B/MX2/FEZ1/BICD1/SUPT5H/CCNT2/NELFB	19
KEGG	hsa04120	Ubiquitin mediated proteolysis	40/2017	142/8135	0.1987	0.7629	0.7237	PPIL2/FBXO2/UBE2G1/PIAS3/UBE2Z/UBE2M/STUB1/UBA7/DET1/KLHL9/UBA1/UBE2I/ANAPC7/CUL2/BTRC/RBX1/UBE2R2/UBE2Q1/CUL7/NEDD4L/UBE2D4/PML/MDM2/SIAH1/UBE2A/NEDD4/SAE1/UBE2K/CDC23/UBE2E3/FBXW11/UBB/WWP2/TRAF6/FANCL/UBE2J1/MAP3K1/UBA52/CDC20/UBE2NL	40
KEGG	hsa03020	RNA polymerase	11/2017	34/8135	0.2019	0.7664	0.727	POLR2H/CD3EAP/POLR3A/POLR1D/POLR1C/POLR2K/POLR3K/POLR1A/POLR2G/POLR1B/CRCP	11
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	126/2017	476/8135	0.2058	0.7725	0.7328	ND6/BECN1/ATG101/UBE2G1/TUBA3C/COX6C/ACTR10/TNF/NDUFS3/DCTN1/CHRM3/COX5B/NDUFB10/UBA7/PPID/BAK1/COX6A2/CSF1/NDUFA9/UBA1/BAD/CTNNB1/FUS/COX1/SLC25A4/PLCG1/ND5/PSMA1/ARAF/PSMC4/DVL3/CSNK1A1L/PSMA6/COX6B1/PLCB2/KIF5B/FZD9/FASLG/FZD7/DVL2/CALML5/ULK2/PSMB6/ALS2/DCTN6/GNAQ/UQCRC2/MAPK12/SPTBN2/DKK2/GRIA2/DNAH1/TRPC3/CACNA1C/APC2/NDUFB3/ATXN2L/NDUFAB1/UQCRFS1/PSMA5/AMBRA1/DCTN5/KLC3/UCHL1/WNT4/CHRM5/NDUFS5/RAB39B/ND4/WNT11/TANK/ND1/RELA/FIG4/PSMA2/MAPK11/DCTN2/COX2/WNT9B/LRP6/NDUFA12/NDUFV2/NDUFA2/NDUFB11/PPP3CA/CASP8/UBB/DNAL4/AGER/TUBA3E/NDUFB5/HRAS/GPX6/ND2/NDUFB4/DNAI1/NDUFA3/PSMD1/PSMD9/KRAS/DERL1/CYTB/HSPA5/PSMC1/FZD6/WNT7B/SNCA/VAPB/WNT2/NOS1/UBE2J1/NDUFB6/NEFM/PPP3R1/DNAH12/KLC4/NDUFA6/MAP1LC3C/CALML3/COX4I2/UBA52/CASP3/MFN1/COX4I1/KIF5A/DNAH14	126
KEGG	hsa04152	AMPK signaling pathway	34/2017	120/8135	0.2106	0.7815	0.7414	PRKAB1/AKT2/PPP2R2D/TSC1/IGF1/CPT1A/MLYCD/EIF4EBP1/PPP2R5D/SIRT1/LEP/HMGCR/RAB11B/CCND1/PRKAG1/PIK3R3/PRKAB2/PDPK1/STRADA/ADIPOR1/STRADB/EEF2/INS/ADIPOR2/PPP2R2A/FOXO3/CREB3L1/PPP2R5A/PRKAA2/IRS1/PCK2/PPP2R3B/PPP2R2C/AKT1	34
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2017	49/8135	0.2145	0.7873	0.7469	GNPDA1/UGP2/GMDS/MPI/GALT/GNE/GMPPA/PMM2/PGM3/UAP1/NAGK/GFPT1/GNPDA2/GNPNAT1/CHIT1	15
KEGG	hsa04710	Circadian rhythm	10/2017	31/8135	0.2204	0.8003	0.7592	PRKAB1/CSNK1D/BTRC/RBX1/PRKAG1/PRKAB2/FBXL3/FBXW11/BHLHE41/PRKAA2	10
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	53/2017	194/8135	0.2277	0.801	0.7598	BECN1/AKT2/IKBKB/IKBKE/BAK1/C3/CTNNB1/FOS/PLCG1/IRF7/STAT2/CHUK/RB1/CALML5/MAPK12/CCND1/PIK3R3/IRF3/PIK3R6/IFNA21/NFATC1/IL6ST/TP53/TCF7L2/TICAM1/HIF1A/RELA/JUN/MAPK11/CCR4/GNG7/ATG3/PPP3CA/CASP8/UBB/CD200R1L/CCR3/HRAS/TCF7/KRAS/IFNA10/IFNA5/PIK3R5/IFNA2/PPP3R1/MYC/MAP1LC3C/CALML3/E2F2/UBA52/CASP3/AKT1/CDKN1A	53
KEGG	hsa05163	Human cytomegalovirus infection	61/2017	225/8135	0.2286	0.801	0.7598	AKT2/IKBKB/PTGER4/TNF/PTGER2/GNAI2/BAK1/ATF6B/ARHGEF1/TSC1/CTNNB1/IL6R/SP1/CHUK/EIF4EBP1/PLCB2/RB1/FASLG/ADCY7/CALML5/SOS2/GNAQ/MAPK12/CCND1/PIK3R3/IRF3/BCAR1/MDM2/IFNA21/NFATC1/TP53/RELA/MAPK11/GNG7/PPP3CA/CASP8/CCR3/CDKN2A/HRAS/ARHGEF11/RAC2/KRAS/IL10RB/IFNA10/CREB3L1/PXN/ITGAV/IFNA5/ADCY4/GRB2/AKAP13/IFNA2/PPP3R1/MYC/CALML3/TAP1/E2F2/TRAF5/CASP3/AKT1/CDKN1A	61
KEGG	hsa04260	Cardiac muscle contraction	25/2017	87/8135	0.2295	0.801	0.7598	COX6C/COX5B/COX6A2/COX1/MYL2/CACNB1/COX6B1/TPM4/MYH6/TNNT2/UQCRC2/CACNA1C/MYL4/UQCRFS1/TPM3/SLC8A2/CACNG4/COX2/CACNG7/CASQ2/ATP1A1/CYTB/TNNI3/COX4I2/COX4I1	25
KEGG	hsa04072	Phospholipase D signaling pathway	41/2017	148/8135	0.2302	0.801	0.7598	AKT2/RRAS2/MRAS/CYTH1/TSC1/PLCG1/CYTH2/DNM1/PLCB2/FYN/AGTR1/MS4A2/ADCY7/PLD2/SOS2/CYTH4/PIK3R3/DGKA/PIK3R6/DGKZ/DGKK/SHC1/PIP5K1A/PLA2G4D/RALA/AGPAT5/GAB1/INS/PDGFC/HRAS/LPAR2/KRAS/ARF1/PIK3R5/ADCY4/GRB2/F2/FCER1A/DNM2/RAPGEF3/AKT1	41
KEGG	hsa00510	N-Glycan biosynthesis	15/2017	50/8135	0.2405	0.8268	0.7843	ALG11/DPM1/ALG3/ALG12/MOGS/TUSC3/DPAGT1/STT3A/ALG1/GANAB/DOLPP1/SRD5A3/MAN1A1/MAN1C1/ALG10B	15
KEGG	hsa05415	Diabetic cardiomyopathy	55/2017	203/8135	0.2442	0.8268	0.7843	ND6/AKT2/COX6C/NDUFS3/COX5B/NDUFB10/MPC1L/COX6A2/NDUFA9/PDK4/COX1/SLC25A4/ND5/SP1/COX6B1/PLCB2/PDHA2/AGTR1/UQCRC2/MAPK12/PIK3R3/NDUFB3/NDUFAB1/UQCRFS1/NDUFS5/ND4/PPP1CB/ND1/RELA/MAPK11/COX2/NDUFA12/NDUFV2/NDUFA2/NDUFB11/GFPT1/INS/AGER/NDUFB5/ND2/NDUFB4/PLN/RAC2/NDUFA3/CYTB/TNNI3/CPT2/COL1A2/NDUFB6/NDUFA6/IRS1/COX4I2/COX4I1/AKT1/CMA1	55
KEGG	hsa04110	Cell cycle	35/2017	126/8135	0.2461	0.8268	0.7843	SMC1A/SMAD4/CCND2/TFDP1/YWHAZ/STAG2/ANAPC7/RB1/CDC25B/CDKN2D/RBX1/CCND1/HDAC1/MDM2/TP53/MCM5/CHEK1/MAD1L1/CDC23/CDC45/MAD2L1/GADD45G/GADD45A/CDKN2C/CDKN2A/MCM2/BUB1/SMC3/CDK7/WEE1/CCNE1/MYC/E2F2/CDC20/CDKN1A	35
KEGG	hsa04920	Adipocytokine signaling pathway	20/2017	69/8135	0.2475	0.8268	0.7843	PRKAB1/AKT2/IKBKB/TNF/CPT1A/CHUK/LEP/PRKAG1/PRKAB2/ACSBG1/NFKBIB/ADIPOR1/RELA/ADIPOR2/POMC/RXRB/PRKAA2/IRS1/PCK2/AKT1	20
KEGG	hsa04722	Neurotrophin signaling pathway	33/2017	119/8135	0.2576	0.8467	0.8033	AKT2/IKBKB/PRDM4/SH2B1/RAP1A/BAD/ZNF274/PLCG1/RAP1B/FASLG/CALML5/SOS2/MAPK12/PIK3R3/PDPK1/NFKBIB/SHC1/TP53/RELA/JUN/MAPK11/GAB1/HRAS/FOXO3/KRAS/TRAF6/GRB2/NTF3/IRS1/MAP3K1/CALML3/AKT1/SH2B3	33
KEGG	hsa04144	Endocytosis	67/2017	251/8135	0.2609	0.8467	0.8033	STAMBP/RAB7A/ZFYVE27/CHMP4A/HGS/IL2RB/CHMP2A/WIPF1/SH3GL2/WIPF2/SNX3/CAV1/CYTH1/VPS26A/CHMP3/CYTH2/VPS37D/MVB12A/EPS15L1/CHMP7/DNM1/KIF5B/TFRC/ACAP2/PSD4/PLD2/CAPZB/RAB11B/RNF41/GIT1/CYTH4/PSD/AP2B1/AGAP5/NEDD4L/PML/ARPC1B/MDM2/GBF1/RAB11FIP2/HSPA1L/NEDD4/PIP5K1A/SNX32/RABEP1/ARRB1/STAM/ACTR3C/RAB5C/HRAS/VPS35/HSPA2/ASAP1/CLTA/ARF1/AMPH/RAB35/LDLRAP1/TRAF6/SNX6/SPG21/CHMP1A/DNM2/ARFGAP2/KIF5A/ARAP1/FOLR3	67
KEGG	hsa04010	MAPK signaling pathway	78/2017	294/8135	0.2611	0.8467	0.8033	AKT2/EPHA2/TAOK2/MAP3K2/IKBKB/TNF/RRAS2/MRAS/RAP1A/CSF1/TAB1/IGF1/FOS/ARAF/CACNB1/MAP3K14/CHUK/MAP3K11/DUSP6/RAP1B/FASLG/CDC25B/FGF3/FLT3LG/SOS2/MAPKAPK3/MAPK12/PPM1A/FGF6/CACNA1C/CSF1R/DUSP8/NFATC1/DUSP9/MAP4K2/ERBB2/TP53/HSPA1L/CACNG4/MAP3K8/PLA2G4D/DUSP10/RELA/JUN/MAPK11/NFKB2/MAP3K12/ARRB1/PPP3CA/MAPK8IP3/EFNA2/GADD45G/GADD45A/INS/PDGFC/RASGRF2/HRAS/CACNG7/VEGFC/HSPA2/RAC2/FGF1/HGF/DUSP1/KRAS/AREG/TRAF6/GRB2/MAP3K13/DUSP7/PPP3R1/NTF3/MYC/MAP3K1/CASP3/SRF/FGF4/AKT1	78
KEGG	hsa05016	Huntington disease	81/2017	306/8135	0.264	0.8478	0.8042	ND6/BECN1/ATG101/TUBA3C/COX6C/ACTR10/NDUFS3/DCTN1/POLR2H/COX5B/NDUFB10/COX6A2/NDUFA9/COX1/SLC25A4/ND5/PSMA1/SP1/PSMC4/PSMA6/COX6B1/PLCB2/KIF5B/BBC3/ULK2/PSMB6/DCTN6/GNAQ/UQCRC2/GRIA2/DNAH1/AP2B1/POLR2K/NDUFB3/NDUFAB1/UQCRFS1/PSMA5/HDAC1/AMBRA1/DCTN5/KLC3/NDUFS5/ND4/TP53/POLR2G/ND1/REST/PSMA2/DCTN2/COX2/NDUFA12/NDUFV2/NDUFA2/TGM2/NDUFB11/CASP8/DNAL4/TUBA3E/NDUFB5/GPX6/ND2/NDUFB4/DNAI1/NDUFA3/PSMD1/PSMD9/CLTA/CYTB/CREB3L1/PSMC1/SLC1A2/NDUFB6/DNAH12/KLC4/NDUFA6/COX4I2/CASP3/UCP1/COX4I1/KIF5A/DNAH14	81
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/2017	89/8135	0.2698	0.8583	0.8142	AKT2/TIRAP/IKBKB/FOS/PLCG1/CHUK/MAPK12/PIK3R3/NFKBIB/PTPN6/NFATC1/TICAM1/HIF1A/RELA/JUN/MAPK11/PPP3CA/HRAS/KRAS/CD28/TRAF6/BATF3/PPP3R1/CD3E/AKT1	25
KEGG	hsa00511	Other glycan degradation	6/2017	18/8135	0.2753	0.8675	0.823	MAN2B2/NEU2/NEU4/MAN2C1/GBA2/NEU3	6
KEGG	hsa04662	B cell receptor signaling pathway	23/2017	82/8135	0.2837	0.8793	0.8341	AKT2/IKBKB/IFITM1/FOS/CD81/CHUK/VAV1/SOS2/PIK3R3/NFKBIB/PTPN6/NFATC1/RELA/JUN/PPP3CA/HRAS/RAC2/KRAS/GRB2/PPP3R1/BTK/CR2/AKT1	23
KEGG	hsa04022	cGMP-PKG signaling pathway	45/2017	167/8135	0.2843	0.8793	0.8341	AKT2/KCNMB1/GNAI2/NPR2/ATF6B/BAD/SLC25A4/PLCB2/AGTR1/KCNJ8/ADCY7/ADRA2B/CALML5/MYH6/GNAQ/GTF2IRD1/PPP1R12A/GATA4/CACNA1C/PIK3R6/NFATC1/SLC8A2/MEF2D/PPP1CB/CNGB1/ADRA2A/ADRA1D/PPP3CA/INS/PLN/ADRB2/ATP1A1/ATP2B2/CREB3L1/ADRA1B/PIK3R5/ADCY4/NPPB/PPP3R1/IRS1/CALML3/ATP2B3/SRF/AKT1/MEF2B	45
KEGG	hsa05012	Parkinson disease	70/2017	266/8135	0.3014	0.9151	0.8681	ND6/SLC39A13/UBE2G1/TUBA3C/COX6C/NDUFS3/GNAI2/COX5B/NDUFB10/UBA7/COX6A2/NDUFA9/UBA1/COX1/SLC25A4/SLC39A7/PLCG1/ND5/PSMA1/PSMC4/PSMA6/COX6B1/KIF5B/CALML5/PSMB6/UQCRC2/SLC39A6/NDUFB3/NDUFAB1/UQCRFS1/PSMA5/KLC3/UCHL1/SLC39A1/NDUFS5/ND4/TP53/ND1/PSMA2/GNAL/COX2/NDUFA12/NDUFV2/NDUFA2/NDUFB11/UBB/TUBA3E/NDUFB5/ND2/NDUFB4/NDUFA3/PSMD1/PSMD9/DUSP1/CYTB/HSPA5/PSMC1/SNCA/UBE2J1/NDUFB6/KLC4/NDUFA6/CALML3/COX4I2/UBA52/CASP3/TXN2/MFN1/COX4I1/KIF5A	70
KEGG	hsa04340	Hedgehog signaling pathway	16/2017	56/8135	0.3014	0.9151	0.8681	CSNK1G2/SUFU/IHH/CSNK1D/CCND2/EFCAB7/CSNK1A1L/DISP1/BTRC/CCND1/ARRB1/FBXW11/GLI2/KIF7/SMO/EVC2	16
KEGG	hsa04950	Maturity onset diabetes of the young	8/2017	26/8135	0.3058	0.9202	0.8729	PAX4/HHEX/BHLHA15/ONECUT1/HES1/NEUROD1/MNX1/INS	8
KEGG	hsa03022	Basal transcription factors	13/2017	45/8135	0.3132	0.934	0.886	GTF2A2/GTF2E1/GTF2H4/TAF8/TAF6L/TAF6/GTF2IRD1/ERCC2/GTF2F2/CDK7/TAF3/ERCC3/GTF2H5	13
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	9/2017	30/8135	0.3166	0.9358	0.8877	ACSS1/CS/HYI/SHMT1/AGXT/GLDC/GRHPR/ACO1/MDH2	9
KEGG	hsa05133	Pertussis	21/2017	76/8135	0.3229	0.9421	0.8937	TIRAP/TNF/IL23A/GNAI2/C3/FOS/CFL1/CALML5/MAPK12/IRF3/ITGA5/TICAM1/RELA/JUN/MAPK11/IL10/C1QC/TRAF6/NOD1/CALML3/CASP3	21
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	6/2017	19/8135	0.3244	0.9421	0.8937	CS/IDH3B/AADAT/GOT2/BCAT2/ACO1	6
KEGG	hsa05134	Legionellosis	16/2017	57/8135	0.3294	0.9437	0.8952	TNF/SAR1B/CLK4/C3/EEF1A1/EEF1A2/RAB1B/EEF1G/SAR1A/HSPA1L/RELA/NFKB2/CASP8/HSPA2/ARF1/CASP3	16
KEGG	hsa05340	Primary immunodeficiency	11/2017	38/8135	0.333	0.9437	0.8952	ORAI1/IGLL1/JAK3/RFX5/DCLRE1C/ADA/TNFRSF13B/CD40/BTK/TAP1/CD3E	11
KEGG	hsa03060	Protein export	7/2017	23/8135	0.3375	0.9437	0.8952	SEC11C/SRPRB/SRP72/SRP68/SEC11A/HSPA5/SEC62	7
KEGG	hsa04614	Renin-angiotensin system	7/2017	23/8135	0.3375	0.9437	0.8952	KLK1/LNPEP/AGTR1/ATP6AP2/PREP/AGTR2/CMA1	7
KEGG	hsa04934	Cushing syndrome	41/2017	155/8135	0.3441	0.9437	0.8952	RBBP5/GNAI2/RAP1A/ATF6B/ORAI1/CTNNB1/MEN1/SP1/PDE8B/DVL3/PLCB2/FZD9/RB1/KMT2D/RAP1B/AGTR1/FZD7/ADCY7/DVL2/GNAQ/CCND1/CACNA1C/APC2/WNT4/WNT11/TCF7L2/AHR/WNT9B/CDKN2C/CDKN2A/TCF7/POMC/PDE8A/CREB3L1/FZD6/WNT7B/ADCY4/WNT2/CCNE1/E2F2/CDKN1A	41
KEGG	hsa04810	Regulation of actin cytoskeleton	57/2017	218/8135	0.3446	0.9437	0.8952	PIP4K2B/CHRM3/MYH11/RRAS2/MRAS/PFN3/MYL7/MYL12B/ARHGEF1/MYL2/ARAF/FGD3/CFL1/VAV1/PIP4K2C/FGF3/TMSB4X/SOS2/ITGB8/ITGA10/GIT1/TIAM1/PPP1R12A/ARHGEF7/FGF6/PIK3R3/APC2/MYH14/MSN/BCAR1/ARPC1B/ARHGEF4/TMSB4Y/FN1/CHRM5/WASF2/PPP1CB/DOCK1/ITGA5/PIP5K1A/PPP1R12C/BRK1/ACTR3C/INS/ITGAE/PDGFC/HRAS/LPAR2/RAC2/FGF1/KRAS/PXN/ITGAV/DIAPH3/F2/DIAPH1/FGF4	57
KEGG	hsa03050	Proteasome	13/2017	46/8135	0.345	0.9437	0.8952	PSMA1/PSMC4/PSMA6/PSMB6/POMP/PSMA5/PSMA2/PSMB9/PSMD1/PSMD9/PSMC1/PSME3/PSMB10	13
KEGG	hsa05100	Bacterial invasion of epithelial cells	21/2017	77/8135	0.3475	0.9437	0.8952	CAV1/CTNNB1/ELMO2/DNM1/CD2AP/PIK3R3/BCAR1/ARPC1B/FN1/SHC1/WASF2/DOCK1/ITGA5/ACTR3C/GAB1/CLTA/PXN/ARHGEF26/DNM2/CDH1/CTNNA2	21
KEGG	hsa05417	Lipid and atherosclerosis	56/2017	215/8135	0.3587	0.9661	0.9165	AKT2/TIRAP/IKBKB/TNF/IKBKE/RAP1A/MIB2/TAB1/ARHGEF1/BAD/FOS/PLCG1/TNFRSF10B/IRF7/CHUK/POU2F2/PLCB2/VAV1/RAP1B/FASLG/CALML5/TNFRSF10A/MAPK12/PIK3R3/IRF3/PDPK1/CASP6/IFNA21/NFATC1/TP53/HSPA1L/TANK/TICAM1/RELA/JUN/MAPK11/PPP3CA/CASP8/APOB/AGER/HRAS/HSPA2/APOA1/RXRB/KRAS/IFNA10/CD40/HSPA5/IFNA5/TRAF6/HSP90AB1/IFNA2/PPP3R1/CALML3/CASP3/AKT1	56
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/2017	70/8135	0.3675	0.982	0.9316	IKBKB/TCIRG1/PLCG1/ADAM10/MAP3K14/CHUK/CSK/ATP6V1C2/ATP6V1B1/MAPK12/GIT1/RELA/JUN/ATP6V1G3/MAPK11/ATP6V0B/NOD1/CASP3/ATP6V0E2	19
KEGG	hsa05135	Yersinia infection	36/2017	137/8135	0.3744	0.9924	0.9415	AKT2/IKBKB/TNF/WIPF1/WIPF2/TAB1/ARHGEF1/FOS/PLCG1/ELMO2/CHUK/VAV1/GNAQ/MAPK12/ARHGEF7/PIK3R3/IRF3/BCAR1/ARPC1B/FN1/NFATC1/WASF2/DOCK1/ITGA5/PIP5K1A/TICAM1/RELA/JUN/MAPK11/IL10/ACTR3C/LCP2/RAC2/PXN/TRAF6/AKT1	36
KEGG	hsa00270	Cysteine and methionine metabolism	14/2017	51/8135	0.381	1	0.9486	AGXT2/BHMT2/MRI1/ENOPH1/LDHB/MTAP/MTR/GOT2/CBS/IL4I1/BCAT2/LACC1/AHCYL1/MDH2	14
KEGG	hsa04977	Vitamin digestion and absorption	7/2017	24/8135	0.3834	1	0.9486	MMACHC/SLC46A1/RBP2/SLC5A6/SLC23A1/APOB/APOA1	7
KEGG	hsa04370	VEGF signaling pathway	16/2017	59/8135	0.3871	1	0.9486	AKT2/BAD/PLCG1/MAPKAPK3/MAPK12/PIK3R3/SH2D2A/PLA2G4D/MAPK11/PPP3CA/HRAS/RAC2/KRAS/PXN/PPP3R1/AKT1	16
KEGG	hsa03320	PPAR signaling pathway	20/2017	75/8135	0.396	1	0.9486	PLIN2/APOA2/CPT1A/ACOX3/SCP2/PDPK1/ACSBG1/ME3/FABP6/PPARD/GK2/ANGPTL4/APOA1/FABP3/RXRB/CPT2/EHHADH/CYP8B1/UCP1/PCK2	20
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	21/2017	79/8135	0.3978	1	0.9486	AKT2/BAD/IGF1/PLCG1/IL6R/ARAF/EIF4EBP1/EIF4E2/SOS2/PIK3R3/ERBB2/SHC1/GAB1/PDGFC/HRAS/HGF/FOXO3/KRAS/NRG2/GRB2/AKT1	21
KEGG	hsa00260	Glycine, serine and threonine metabolism	11/2017	40/8135	0.4041	1	0.9486	AGXT2/PGAM2/PGAM4/SHMT1/CBS/AGXT/GLDC/GRHPR/ALAS1/CHDH/GCAT	11
KEGG	hsa04962	Vasopressin-regulated water reabsorption	12/2017	44/8135	0.4073	1	0.9486	DCTN1/DYNC2LI1/DCTN6/RAB11B/DYNLL1/DYNC1H1/DCTN5/DCTN2/STX4/RAB5C/DYNC1I1/CREB3L1	12
KEGG	hsa04371	Apelin signaling pathway	36/2017	139/8135	0.4127	1	0.9486	PRKAB1/BECN1/SMAD4/AKT2/GNAI2/RRAS2/MRAS/EGR1/MYL2/PLCB2/AGTR1/ADCY7/CALML5/GNAQ/CCND1/PRKAG1/PRKAB2/MYL4/PIK3R6/SLC8A2/MEF2D/GNG7/HRAS/KRAS/PIK3R5/ADCY4/NOS1/PRKAA2/KLF2/MAP1LC3C/CALML3/CDH1/UCP1/APLNR/AKT1/MEF2B	36
KEGG	hsa04621	NOD-like receptor signaling pathway	47/2017	184/8135	0.4344	1	0.9486	RIPK3/NLRP1/RNASEL/IKBKB/TP53BP1/TNF/RNF31/P2RX7/IKBKE/TAB1/OAS2/IRF7/OAS3/STAT2/CHUK/PLCB2/OAS1/NOD2/TRIP6/MAPK12/RBCK1/MAVS/IRF3/NFKBIB/ATG16L1/IFNA21/TANK/TICAM1/RELA/JUN/MAPK11/GBP3/CASP8/PSTPIP1/TAB3/CASP5/IFNA10/IFNA5/TRAF6/HSP90AB1/TRPV2/NOD1/IFNA2/MAP1LC3C/TRAF5/TXN2/MFN1	47
KEGG	hsa05203	Viral carcinogenesis	52/2017	204/8135	0.4349	1	0.9486	MRPS18B/GTF2A2/GTF2E1/BAK1/STAT5A/ATF6B/GTF2H4/DNAJA3/BAD/C3/CCND2/YWHAZ/IRF7/RB1/RBPJ/CCND1/HDAC8/TRAF1/JAK3/PIK3R3/IRF3/DDX3X/HDAC1/MDM2/IL6ST/TP53/CHD4/CHEK1/MAD1L1/RELA/JUN/CCR4/NFKB2/CASP8/CCR3/HDAC7/CDKN2A/HRAS/HPN/KRAS/CREB3L1/PXN/VAC14/PSMC1/EGR2/GRB2/CCNE1/TRAF5/CASP3/CDC20/SRF/CDKN1A	52
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	10/2017	37/8135	0.4381	1	0.9486	IGF1/PIK3R3/NEDD4L/PDPK1/INS/ATP1A1/KRAS/SGK1/IRS1/NR3C2	10
KEGG	hsa05020	Prion disease	69/2017	273/8135	0.4496	1	0.9486	ND6/TUBA3C/COX6C/TNF/STIP1/NDUFS3/COX5B/NDUFB10/NCAM1/COX6A2/EGR1/ATF6B/NDUFA9/CAV1/BAD/COX1/SLC25A4/ND5/PSMA1/PSMC4/PSMA6/COX6B1/KIF5B/FYN/PSMB6/UQCRC2/MAPK12/PIK3R3/CACNA1C/NDUFB3/NDUFAB1/UQCRFS1/PSMA5/KLC3/NDUFS5/ND4/HSPA1L/ND1/PSMA2/MAPK11/COX2/NDUFA12/NDUFV2/NDUFA2/NDUFB11/PPP3CA/TUBA3E/NDUFB5/ND2/C1QC/NDUFB4/HSPA2/RAC2/NDUFA3/PSMD1/PSMD9/CYTB/CREB3L1/HSPA5/PSMC1/NDUFB6/PPP3R1/KLC4/NDUFA6/COX4I2/C8G/CASP3/COX4I1/KIF5A	69
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/2017	14/8135	0.4714	1	0.9486	ST3GAL3/B3GNT7/CHST2/B3GNT2	4
KEGG	hsa05142	Chagas disease	26/2017	102/8135	0.4731	1	0.9486	AKT2/IKBKB/TNF/PPP2R2D/GNAI2/C3/FOS/CHUK/PLCB2/FASLG/GNAQ/MAPK12/PIK3R3/TICAM1/RELA/JUN/MAPK11/GNAL/IL10/CASP8/C1QC/PPP2R2A/TRAF6/CD3E/PPP2R2C/AKT1	26
KEGG	hsa05146	Amoebiasis	26/2017	102/8135	0.4731	1	0.9486	RAB7A/PRDX1/TNF/COL4A4/PLCB2/COL4A3/CD1A/GNAQ/COL4A1/PIK3R3/LAMB1/COL4A2/FN1/COL4A5/RELA/GNAL/IL10/RAB5C/SERPINB6/LAMA5/SERPINB13/CD1D/COL1A2/C8G/CASP3/LAMA3	26
KEGG	hsa04657	IL-17 signaling pathway	24/2017	94/8135	0.4736	1	0.9486	IKBKB/TNF/IKBKE/IL17B/FOS/CHUK/FOSB/IL4/MAPK12/CCL17/FOSL1/RELA/JUN/MAPK11/CSF3/IL17D/CASP8/IL17A/TAB3/TRAF6/HSP90AB1/TRAF5/CASP3/SRSF1	24
KEGG	hsa05410	Hypertrophic cardiomyopathy	23/2017	90/8135	0.4738	1	0.9486	PRKAB1/TNF/IGF1/MYL2/CACNB1/TPM4/MYH6/TNNT2/ITGB8/ITGA10/PRKAG1/CACNA1C/PRKAB2/TPM3/SLC8A2/TTN/CACNG4/ITGA5/DAG1/CACNG7/TNNI3/ITGAV/PRKAA2	23
KEGG	hsa00790	Folate biosynthesis	7/2017	26/8135	0.4749	1	0.9486	AKR1C3/MOCS1/FPGS/CBR1/TPH2/MOCS2/GPHN	7
KEGG	hsa05144	Malaria	13/2017	50/8135	0.4756	1	0.9486	TNF/CD81/GYPC/SDC1/GYPB/PECAM1/IL10/THBS1/CSF3/HGF/CD40/GYPA/ACKR1	13
KEGG	hsa05418	Fluid shear stress and atherosclerosis	35/2017	139/8135	0.4907	1	0.9486	AKT2/IKBKB/TNF/SUMO2/SUMO1/CAV1/CTNNB1/FOS/CHUK/GSTA2/SUMO4/CALML5/MAPK12/GSTA4/PIK3R3/SDC1/PECAM1/TP53/MGST1/RELA/GPC1/JUN/MAPK11/RAC2/DUSP1/ITGAV/HSP90AB1/HMOX1/MGST3/ACVR2B/PRKAA2/KLF2/CALML3/TXN2/AKT1	35
KEGG	hsa04935	Growth hormone synthesis, secretion and action	30/2017	119/8135	0.4934	1	0.9486	AKT2/GNAI2/STAT5A/ATF6B/IGF1/FOS/PLCG1/PLCB2/ADCY7/SOS2/GHRH/GNAQ/MAPK12/PIK3R3/CACNA1C/BCAR1/SHC1/MAPK11/JUNB/SST/HRAS/SSTR2/SSTR3/KRAS/CREB3L1/ADCY4/GRB2/IRS1/MAP3K1/AKT1	30
KEGG	hsa00514	Other types of O-glycan biosynthesis	12/2017	47/8135	0.5093	1	0.9486	LFNG/MFNG/ST3GAL3/POMT1/POC1B-GALNT4/POFUT1/GALNT6/GALNT11/GALNT15/GALNT18/GALNT12/POMT2	12
KEGG	hsa04142	Lysosome	33/2017	132/8135	0.5119	1	0.9486	LAMP3/ENTPD4/ARSA/GGA1/TCIRG1/CLN3/IDUA/CTSE/PLA2G15/AP3S1/SGSH/PSAP/GGA3/CLN5/NAGPA/CTSW/CTSC/ACP2/SMPD1/AP4M1/NPC1/AP4B1/AP1G2/SUMF1/GLA/ATP6V0B/GNPTAB/AP1S1/NPC2/CLTA/HYAL1/SLC17A5/AP3M1	33
KEGG	hsa04620	Toll-like receptor signaling pathway	26/2017	104/8135	0.5186	1	0.9486	AKT2/TIRAP/IKBKB/TNF/IKBKE/TAB1/FOS/IRF7/CHUK/MAPK12/PIK3R3/IRF3/IRF5/IFNA21/MAP3K8/TICAM1/RELA/JUN/MAPK11/CASP8/IFNA10/CD40/IFNA5/TRAF6/IFNA2/AKT1	26
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	25/2017	100/8135	0.5197	1	0.9486	TNF/TNFRSF14/IL2RB/CSF1/TNFRSF10D/CXCL13/IL6R/TNFRSF10B/CX3CR1/CCR7/TNFRSF10A/CCL17/CCL26/ACKR3/CSF1R/IL6ST/CCR4/IL10/CCR3/IL20RA/IL10RB/CCL27/IL22RA1/CCL16/CXCR3	25
KEGG	hsa00515	Mannose type O-glycan biosynthesis	6/2017	23/8135	0.5225	1	0.9486	POMGNT1/ST3GAL3/POMT1/B3GAT2/FKRP/POMT2	6
KEGG	hsa04390	Hippo signaling pathway	39/2017	157/8135	0.5257	1	0.9486	SMAD4/PPP2R2D/CSNK1D/CTNNB1/CCND2/YWHAZ/DVL3/FZD9/BBC3/FZD7/DVL2/BTRC/CCND1/NKD2/APC2/MOB1A/ID2/WNT4/PPP1CB/WNT11/TCF7L2/WNT9B/FBXW11/BMP8A/TCF7/PPP2R2A/FGF1/GLI2/AREG/FZD6/WNT7B/WNT2/SMAD7/CRB2/BMP2/MYC/CDH1/CTNNA2/PPP2R2C	39
KEGG	hsa01240	Biosynthesis of cofactors	38/2017	153/8135	0.5267	1	0.9486	UMPS/LIAS/COQ3/COX15/AK5/COQ6/UGP2/COQ7/COQ2/MOCS1/MPI/RDH11/NFS1/CAD/PANK2/GMPPA/GGCX/PMM2/FPGS/MTHFD2/KMO/RDH12/MTHFD1/SHMT1/IDO1/MOCS2/BCAT2/COX10/FECH/FLAD1/COQ5/DHODH/ALAS1/AKR1A1/PNPO/OXSM/GPHN/AK2	38
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	55/2017	222/8135	0.5291	1	0.9486	SMAD4/AKT2/IKBKB/TNF/IL2RB/KAT5/RANBP3/EGR1/STAT5A/ATF6B/CCND2/SLC25A4/FOS/CRTC3/MAP3K14/CHUK/ANAPC7/RB1/ADCY7/CCND1/GPS2/JAK3/PIK3R3/FOSL1/NFATC1/TP53/MSX1/CHEK1/MAD1L1/RELA/JUN/CDC23/NFKB2/MAD2L1/PPP3CA/CDKN2C/CDKN2A/HRAS/TRRAP/KRAS/CREB3L1/VAC14/CD40/ADCY4/EGR2/CCNE1/PPP3R1/MYC/MAP3K1/E2F2/CD3E/CDC20/SRF/AKT1/CDKN1A	55
KEGG	hsa04140	Autophagy - animal	35/2017	141/8135	0.5297	1	0.9486	RAB7A/BECN1/ATG101/AKT2/STX17/RRAS2/MRAS/RAB33B/TSC1/BAD/RRAGB/MTMR4/ULK2/HMGB1/VMP1/PIK3R3/PDPK1/ATG16L1/AMBRA1/RAB39B/ATG4C/TANK/HIF1A/PRAP1/ATG3/INS/ATG4B/ATG4A/HRAS/KRAS/TRAF6/PRKAA2/IRS1/MAP1LC3C/AKT1	35
KEGG	hsa04136	Autophagy - other	8/2017	32/8135	0.5571	1	0.9486	BECN1/ATG101/ULK2/ATG16L1/ATG4C/ATG3/ATG4B/ATG4A	8
KEGG	hsa05164	Influenza A	42/2017	171/8135	0.5582	1	0.9486	RNASEL/AKT2/IKBKB/TNF/IKBKE/NXF1/RAE1/BAK1/OAS2/SLC25A4/TNFRSF10B/IRF7/OAS3/STAT2/CHUK/OAS1/MX1/FASLG/TNFRSF10A/RAB11B/MAVS/PIK3R3/IRF3/PML/NFKBIB/PABPN1/IFNA21/KPNA1/RSAD2/TICAM1/MX2/RELA/HNRNPUL1/CASP8/IFNA10/IFNA5/IFIH1/IFNA2/KPNA7/DDX58/CASP3/AKT1	42
KEGG	hsa00564	Glycerophospholipid metabolism	24/2017	98/8135	0.5671	1	0.9486	LYPLA2/LCAT/PLA2G6/PCYT1A/GPAM/LPCAT3/PLA2G15/PLD2/GPCPD1/LPCAT4/PNPLA6/DGKA/PISD/DGKZ/DGKK/CEPT1/PLA2G4D/PLA2G2A/PLD4/ACHE/AGPAT5/LPIN1/LPIN3/MBOAT1	24
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/2017	24/8135	0.5688	1	0.9486	B3GAT3/HS6ST3/GLCE/EXT2/EXTL3/XYLT2	6
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/2017	20/8135	0.577	1	0.9486	B3GAT3/CHST12/CHPF2/UST/XYLT2	5
KEGG	hsa04723	Retrograde endocannabinoid signaling	36/2017	148/8135	0.585	1	0.9486	ND6/NDUFS3/GNAI2/NDUFB10/GABRB3/ABHD6/NDUFA9/ND5/GABRD/PLCB2/ADCY7/GNAQ/MAPK12/GABRA3/GRIA2/CACNA1C/DAGLB/NDUFB3/NDUFAB1/NDUFS5/ND4/ND1/MAPK11/GNG7/NDUFA12/NDUFV2/NDUFA2/NDUFB11/NDUFB5/ND2/NDUFB4/NDUFA3/ADCY4/NDUFB6/NDUFA6/GABRP	36
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	9/2017	37/8135	0.5894	1	0.9486	AGXT2/NAT8L/CAD/PPAT/GOT2/GAD1/GFPT1/AGXT/IL4I1	9
KEGG	hsa04015	Rap1 signaling pathway	51/2017	210/8135	0.5954	1	0.9486	AKT2/EPHA2/GNAI2/MRAS/PFN3/RAP1A/CSF1/IGF1/CTNNB1/PLCG1/RAPGEF6/PLCB2/VAV1/RAP1B/ADCY7/CALML5/FGF3/GNAQ/MAPK12/TIAM1/FGF6/PIK3R3/CSF1R/BCAR1/RASSF5/SIPA1L3/PRKD2/MAPK11/RALA/THBS1/FARP2/EFNA2/INS/PDGFC/HRAS/LCP2/LPAR2/VEGFC/RAC2/FGF1/HGF/KRAS/ADCY4/RAP1GAP/CALML3/CDH1/MAGI1/RAPGEF3/FGF4/AKT1/PLCE1	51
KEGG	hsa03460	Fanconi anemia pathway	13/2017	54/8135	0.601	1	0.9486	PALB2/FANCE/TOP3A/TOP3B/RMI1/HES1/POLH/BRIP1/RPA2/ATRIP/FANCL/SLX4/REV1	13
KEGG	hsa04668	TNF signaling pathway	27/2017	112/8135	0.6036	1	0.9486	RIPK3/AKT2/IKBKB/TNF/ATF6B/CSF1/CASP10/TAB1/FOS/MAP3K14/CHUK/NOD2/MAPK12/TRAF1/PIK3R3/MAP3K8/RELA/JUN/MAPK11/CASP8/JUNB/VEGFC/TAB3/CREB3L1/TRAF5/CASP3/AKT1	27
KEGG	hsa04064	NF-kappa B signaling pathway	25/2017	104/8135	0.6089	1	0.9486	TIRAP/IKBKB/TNF/CARD10/TAB1/EDA/EDAR/PLCG1/UBE2I/EDA2R/MAP3K14/CHUK/TRAF1/TICAM1/RELA/PIDD1/NFKB2/GADD45G/GADD45A/TAB3/CD40/TRAF6/BTK/DDX58/TRAF5	25
KEGG	hsa04926	Relaxin signaling pathway	31/2017	129/8135	0.6139	1	0.9486	AKT2/GNAI2/ATF6B/INSL3/RLN2/COL4A4/FOS/PLCB2/COL4A3/ADCY7/SOS2/MAPK12/COL4A1/PIK3R3/COL4A2/SHC1/COL4A5/RELA/JUN/MAPK11/GNG7/ARRB1/HRAS/VEGFC/KRAS/CREB3L1/ADCY4/GRB2/NOS1/COL1A2/AKT1	31
KEGG	hsa04725	Cholinergic synapse	27/2017	113/8135	0.6242	1	0.9486	AKT2/CHRM3/GNAI2/FOS/KCNQ3/PLCB2/FYN/ADCY7/GNAQ/KCNJ12/PIK3R3/CACNA1C/PIK3R6/CHRM5/KCNJ2/SLC18A3/CHRNB4/GNG7/CHRNB2/ACHE/HRAS/KRAS/CREB3L1/PIK3R5/ADCY4/SLC5A7/AKT1	27
KEGG	hsa04916	Melanogenesis	24/2017	101/8135	0.6333	1	0.9486	GNAI2/CTNNB1/DVL3/PLCB2/FZD9/FZD7/ADCY7/DVL2/CALML5/GNAQ/WNT4/WNT11/TCF7L2/WNT9B/HRAS/TCF7/POMC/KRAS/CREB3L1/FZD6/WNT7B/ADCY4/WNT2/CALML3	24
KEGG	hsa00450	Selenocompound metabolism	4/2017	17/8135	0.6399	1	0.9486	TXNRD2/MTR/MARS2/SEPHS2	4
KEGG	hsa04012	ErbB signaling pathway	20/2017	85/8135	0.6479	1	0.9486	AKT2/STAT5A/BAD/PLCG1/ARAF/EIF4EBP1/SOS2/PIK3R3/ERBB2/SHC1/JUN/GAB1/HRAS/KRAS/NRG2/AREG/GRB2/MYC/AKT1/CDKN1A	20
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	25/2017	106/8135	0.6508	1	0.9486	GNAI2/EGR1/ATF6B/ARHGEF1/FOS/ARAF/SP1/MMP24/PLCB2/ADCY7/PLD2/GNAQ/GCM2/PDE4C/PDE4D/MEF2D/LRP6/ARRB1/ARHGEF11/RXRB/CREB3L1/ADCY4/AKAP13/SLC9A3R1/CDKN1A	25
KEGG	hsa00513	Various types of N-glycan biosynthesis	9/2017	39/8135	0.6584	1	0.9486	ALG11/ALG3/ALG12/ST3GAL3/TUSC3/STT3A/ALG1/MAN1A1/MAN1C1	9
KEGG	hsa04530	Tight junction	40/2017	169/8135	0.6629	1	0.9486	PRKAB1/TUBA3C/PPP2R2D/MYH11/RAP1A/MYL12B/MYL2/RAPGEF6/CD1A/TJP2/CCND1/TIAM1/MYL6B/PRKAG1/GATA4/PRKAB2/MYH14/NEDD4L/MSN/ARPC1B/ERBB2/CLDN24/SYMPK/CLDN10/RAB13/CLDN15/NEDD4/JUN/ACTR3C/CRB3/TUBA3E/ARHGEF18/PPP2R2A/CD1D/CGN/SLC9A3R1/PRKAA2/MAP3K1/MAGI1/PPP2R2C	40
KEGG	hsa04721	Synaptic vesicle cycle	18/2017	78/8135	0.6799	1	0.9486	SLC6A11/TCIRG1/DNM1/ATP6V1C2/ATP6V1B1/AP2B1/STX1B/CPLX2/ATP6V1G3/ATP6V0B/SLC18A3/SLC6A12/RAB3A/CLTA/SLC1A2/DNM2/ATP6V0E2/SLC6A9	18
KEGG	hsa03010	Ribosome	37/2017	158/8135	0.6865	1	0.9486	RPL26/MRPL27/RPL19/MRPS2/RPL21/RPS8/MRPL21/MRPS5/RPL30/RPL36A-HNRNPH2/RPLP2/RPS13/RPS15A/RSL24D1/RPL36AL/RPLP0/RPS24/RPL10L/RPL6/RPS27/RPL23A/RPL12/RPS7/RPS19/RPS11/MRPS12/RPL27/RPS4Y1/MRPL9/RPSA/RPL24/RPS18/MRPS14/MRPL16/RPL32/UBA52/RPL18A	37
KEGG	hsa05145	Toxoplasmosis	26/2017	112/8135	0.6865	1	0.9486	AKT2/IKBKB/TNF/GNAI2/TAB1/BAD/CHUK/MAPK12/PDPK1/NFKBIB/LAMB1/PIK3R6/HSPA1L/RELA/MAPK11/IL10/CASP8/HSPA2/LAMA5/IL10RB/CD40/PIK3R5/TRAF6/CASP3/AKT1/LAMA3	26
KEGG	hsa00061	Fatty acid biosynthesis	4/2017	18/8135	0.6875	1	0.9486	MCAT/ACSBG1/OLAH/OXSM	4
KEGG	hsa04921	Oxytocin signaling pathway	36/2017	154/8135	0.6893	1	0.9486	PRKAB1/GNAI2/NPR2/FOS/CACNB1/OXTR/PLCB2/ADCY7/CALML5/GNAQ/CCND1/KCNJ12/MYL6B/PRKAG1/PPP1R12A/CACNA1C/PRKAB2/PIK3R6/NFATC1/PPP1CB/CACNG4/KCNJ2/EEF2/PLA2G4D/PPP1R12C/JUN/PPP3CA/HRAS/CACNG7/KRAS/PIK3R5/ADCY4/PRKAA2/PPP3R1/CALML3/CDKN1A	36
KEGG	hsa04919	Thyroid hormone signaling pathway	28/2017	121/8135	0.6976	1	0.9486	AKT2/BAD/CTNNB1/PLCG1/PLCB2/PLCD4/MED12/MYH6/CCND1/GATA4/PIK3R3/PDPK1/HDAC1/MDM2/WNT4/TP53/SLC16A2/HIF1A/HRAS/MED17/PLN/ATP1A1/RXRB/KRAS/ITGAV/MYC/AKT1/PLCE1	28
KEGG	hsa04915	Estrogen signaling pathway	32/2017	138/8135	0.7013	1	0.9486	AKT2/GNAI2/ATF6B/FOS/SP1/PLCB2/ADCY7/CALML5/SOS2/GNAQ/PIK3R3/RARA/KRT38/SHC1/KRT34/HSPA1L/KRT9/KRT10/JUN/KRT33B/HRAS/HSPA2/POMC/KRAS/CREB3L1/ADCY4/GRB2/HSP90AB1/KRT12/CALML3/AKT1/KRT14	32
KEGG	hsa05414	Dilated cardiomyopathy	22/2017	96/8135	0.7031	1	0.9486	TNF/IGF1/MYL2/CACNB1/ADCY7/TPM4/MYH6/TNNT2/ITGB8/ITGA10/CACNA1C/TPM3/SLC8A2/TTN/CACNG4/ITGA5/DAG1/CACNG7/PLN/TNNI3/ITGAV/ADCY4	22
KEGG	hsa05130	Pathogenic Escherichia coli infection	46/2017	197/8135	0.7086	1	0.9486	TUBA3C/TIRAP/IKBKB/TNF/ABI1/MYH11/BAK1/WIPF1/WIPF2/TAB1/ARHGEF1/CYTH1/FOS/CYTH2/TNFRSF10B/CHUK/FYN/FASLG/TNFRSF10A/MAPK12/CYTH4/MYH14/ARPC1B/NFKBIB/PTPN6/CLDN24/CLDN10/WASF2/CLDN15/RELA/BRK1/JUN/MAPK11/CASP8/ACTR3C/SEC24C/TUBA3E/LPAR2/ARHGEF11/TAB3/ARF1/TRAF6/F2/SLC9A3R1/CASP3/MYO1D	46
KEGG	hsa05131	Shigellosis	58/2017	247/8135	0.7094	1	0.9486	BECN1/AKT2/IKBKB/TNF/RNF31/PFN3/MYL7/CAPNS1/PPID/MYL12B/TAB1/CYTH1/C3/RRAGB/MYL2/PLCG1/CYTH2/ELMO2/CHUK/PLCB2/PLCD4/BTRC/RBX1/MAPK12/RBCK1/CYTH4/PIK3R3/IRF3/UBE2D4/BCAR1/ARPC1B/NFKBIB/ATG16L1/MDM2/WASF2/TP53/DOCK1/ITGA5/RELA/JUN/MAPK11/FBXW11/ACTR3C/UBB/FOXO3/TAB3/ARF1/PXN/TRAF6/NOD1/MAP1LC3C/CBX3/TRAF5/UBA52/DIAPH1/UBE2NL/AKT1/PLCE1	58
KEGG	hsa02010	ABC transporters	10/2017	45/8135	0.7099	1	0.9486	ABCC2/ABCB10/ABCA9/ABCD4/ABCC10/ABCB8/ABCB5/ABCB1/ABCA7/TAP1	10
KEGG	hsa00640	Propanoate metabolism	7/2017	32/8135	0.7136	1	0.9486	LDHB/MLYCD/ACSS1/ACOX3/DBT/SUCLG1/EHHADH	7
KEGG	hsa04720	Long-term potentiation	15/2017	67/8135	0.7205	1	0.9486	RAP1A/ARAF/PLCB2/RAP1B/CALML5/GNAQ/GRIA2/CACNA1C/PPP1CB/PPP3CA/HRAS/KRAS/PPP3R1/CALML3/RAPGEF3	15
KEGG	hsa04114	Oocyte meiosis	30/2017	131/8135	0.7248	1	0.9486	SMC1A/SPDYE1/IGF1/YWHAZ/FBXO43/ANAPC7/PPP2R5D/ADCY7/CALML5/BTRC/RBX1/MAPK12/PPP1CB/MAD1L1/CDC23/MAPK11/FBXW11/MAD2L1/PPP3CA/INS/BUB1/SMC3/ADCY4/PPP2R5A/CCNE1/PPP3R1/CALML3/CDC20/FBXO5/SPDYE2	30
KEGG	hsa04970	Salivary secretion	21/2017	93/8135	0.7275	1	0.9486	CHRM3/PRB1/PLCB2/ADCY7/CALML5/GNAQ/AMY2B/MUC7/ADRA1D/ADRB2/ATP1A1/AMY2A/ATP2B2/ADRA1B/ADCY4/CST4/NOS1/CST3/CALML3/ATP2B3/KCNN4	21
KEGG	hsa04979	Cholesterol metabolism	11/2017	50/8135	0.7276	1	0.9486	LCAT/APOA2/MYLIP/NPC1/APOB/ANGPTL4/APOA1/NPC2/VAPA/LDLRAP1/VAPB	11
KEGG	hsa04380	Osteoclast differentiation	29/2017	128/8135	0.7448	1	0.9486	AKT2/IKBKB/TNF/CSF1/TAB1/FOS/MAP3K14/STAT2/CHUK/FYN/FOSB/MAPK12/PIK3R3/CSF1R/FOSL1/NFATC1/RELA/JUN/MAPK11/NFKB2/FCGR3A/PPP3CA/JUNB/LCP2/TRAF6/GRB2/PPP3R1/BTK/AKT1	29
KEGG	hsa00051	Fructose and mannose metabolism	7/2017	33/8135	0.7453	1	0.9486	ALDOC/GMDS/MPI/GMPPA/PMM2/ALDOB/TPI1	7
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2017	15/8135	0.7586	1	0.9486	ST8SIA1/GLA/FUT1	3
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/2017	15/8135	0.7586	1	0.9486	ST8SIA1/ST8SIA5/ST3GAL5	3
KEGG	hsa00730	Thiamine metabolism	3/2017	15/8135	0.7586	1	0.9486	AK5/NFS1/AK2	3
KEGG	hsa04640	Hematopoietic cell lineage	22/2017	99/8135	0.7591	1	0.9486	CD7/TNF/CSF1/IL6R/IL11RA/IL4R/TFRC/FCER2/IL4/CD1A/FLT3LG/CSF1R/IL7/ITGA5/CSF3/IL5RA/CD1D/CD37/CD55/GYPA/CD3E/CR2	22
KEGG	hsa00620	Pyruvate metabolism	10/2017	47/8135	0.7628	1	0.9486	LDHB/ACSS1/PDHA2/DLAT/ME3/HAGH/GRHPR/MDH2/AKR1A1/PCK2	10
KEGG	hsa04924	Renin secretion	15/2017	69/8135	0.7639	1	0.9486	PTGER4/PTGER2/GNAI2/ORAI1/PLCB2/AGTR1/CALML5/GNAQ/CACNA1C/KCNJ2/PPP3CA/ADRB2/EDN2/PPP3R1/CALML3	15
KEGG	hsa05321	Inflammatory bowel disease	14/2017	65/8135	0.7715	1	0.9486	TNF/IL23A/IL21R/IL4R/IL4/NOD2/NFATC1/FOXP3/RELA/JUN/IL10/IL21/IL17A/MAF	14
KEGG	hsa05017	Spinocerebellar ataxia	32/2017	143/8135	0.7783	1	0.9486	BECN1/ATG101/CIC/AKT2/NOP56/KAT5/SLC25A4/PSMA1/SP1/PSMC4/PSMA6/PLCB2/ULK2/PSMB6/RBPJ/MYOD1/GNAQ/SPTBN2/ATXN10/GRIA2/TRPC3/PIK3R3/ATXN2L/PSMA5/AMBRA1/PSMA2/PSMD1/PSMD9/NFYA/PSMC1/PUM1/AKT1	32
KEGG	hsa04014	Ras signaling pathway	53/2017	232/8135	0.7793	1	0.9486	AKT2/PLA2G6/EPHA2/IKBKB/RRAS2/MRAS/RAP1A/CSF1/BAD/IGF1/PLCG1/CHUK/RAP1B/FASLG/PLD2/CALML5/RASAL3/FGF3/FLT3LG/SOS2/TIAM1/FGF6/PIK3R3/CSF1R/RASSF5/SYNGAP1/SHOC2/SHC1/PLA2G4D/RELA/PLA2G2A/RALA/GNG7/RGL1/EFNA2/RAB5C/GAB1/INS/PDGFC/RASGRF2/HRAS/KSR1/VEGFC/RAC2/FGF1/HGF/KRAS/GRB2/NTF3/CALML3/FGF4/AKT1/PLCE1	53
KEGG	hsa00561	Glycerolipid metabolism	13/2017	61/8135	0.7797	1	0.9486	GPAM/PNLIPRP2/DGKA/DGKZ/DGKK/GLA/GK2/AGK/AGPAT5/LPIN1/LPIN3/AKR1A1/MBOAT1	13
KEGG	hsa05230	Central carbon metabolism in cancer	15/2017	70/8135	0.7838	1	0.9486	AKT2/PGAM2/PGAM4/LDHB/PDHA2/PIK3R3/ERBB2/TP53/HIF1A/HRAS/SLC7A5/KRAS/SLC1A5/MYC/AKT1	15
KEGG	hsa04658	Th1 and Th2 cell differentiation	20/2017	92/8135	0.7872	1	0.9486	IKBKB/IL2RB/STAT5A/FOS/PLCG1/IL4R/CHUK/IL4/RBPJ/MAPK12/JAK3/NFKBIB/NFATC1/RELA/JUN/MAPK11/PPP3CA/PPP3R1/CD3E/MAF	20
KEGG	hsa05170	Human immunodeficiency virus 1 infection	48/2017	212/8135	0.7915	1	0.9486	AKT2/IKBKB/TNF/GNAI2/BAK1/TAB1/BAD/FOS/PLCG1/CFL1/CHUK/FASLG/CALML5/BTRC/RBX1/GNAQ/MAPK12/PIK3R3/IRF3/IFNA21/NFATC1/APOBEC3F/AP1G2/CHEK1/RELA/JUN/MAPK11/GNG7/FBXW11/PPP3CA/CASP8/AP1S1/HRAS/RAC2/KRAS/IFNA10/PXN/IFNA5/TRAF6/WEE1/IFNA2/PPP3R1/CALML3/TAP1/CD3E/TRAF5/CASP3/AKT1	48
KEGG	hsa04670	Leukocyte transendothelial migration	25/2017	114/8135	0.7929	1	0.9486	GNAI2/MYL7/RAP1A/MYL12B/CTNNB1/MYL2/PLCG1/TXK/VAV1/RAP1B/MAPK12/PIK3R3/MSN/BCAR1/RASSF5/PECAM1/CLDN24/CLDN10/CLDN15/MAPK11/RAC2/PXN/CD99L2/CTNNA2/RAPGEF3	25
KEGG	hsa01230	Biosynthesis of amino acids	16/2017	75/8135	0.7952	1	0.9486	PGAM2/PGAM4/ALDOC/CS/MTR/IDH3B/ALDOB/PYCR2/SHMT1/GOT2/TPI1/CBS/BCAT2/ACO1/TKTL1/TALDO1	16
KEGG	hsa00360	Phenylalanine metabolism	3/2017	16/8135	0.798	1	0.9486	GOT2/IL4I1/ALDH3B2	3
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/2017	53/8135	0.7981	1	0.9486	KLK1/DNM1/PLCB2/GNAQ/AP2B1/SLC8A2/ATP1A1/CLTA/ATP2B2/ATP2B3/DNM2	11
KEGG	hsa05320	Autoimmune thyroid disease	11/2017	53/8135	0.7981	1	0.9486	FASLG/IL4/IFNA21/IL10/IFNA10/TSHR/CD28/CD40/PRF1/IFNA5/IFNA2	11
KEGG	hsa00770	Pantothenate and CoA biosynthesis	4/2017	21/8135	0.8028	1	0.9486	CSAD/ENPP3/PANK2/BCAT2	4
KEGG	hsa04062	Chemokine signaling pathway	43/2017	192/8135	0.8051	1	0.9486	AKT2/IKBKB/GNAI2/RAP1A/BAD/CXCL13/PLCG1/CX3CR1/CCR7/STAT2/CHUK/PLCB2/VAV1/RAP1B/ADCY7/SOS2/GNAQ/CCL17/TIAM1/CCL26/JAK3/PIK3R3/BCAR1/NFKBIB/PIK3R6/SHC1/RELA/CCR4/GNG7/ARRB1/CCR3/HRAS/RAC2/FOXO3/KRAS/CCL27/PXN/CCL16/PIK3R5/ADCY4/GRB2/CXCR3/AKT1	43
KEGG	hsa04914	Progesterone-mediated oocyte maturation	22/2017	102/8135	0.8079	1	0.9486	SPDYE1/AKT2/GNAI2/IGF1/ARAF/ANAPC7/CDC25B/ADCY7/MAPK12/PIK3R3/MAD1L1/CDC23/MAPK11/MAD2L1/INS/KRAS/BUB1/ADCY4/HSP90AB1/STK10/SPDYE2/AKT1	22
KEGG	hsa00565	Ether lipid metabolism	10/2017	49/8135	0.8086	1	0.9486	PAFAH2/PLA2G6/PLD2/LPCAT4/GDPD1/ENPP2/CEPT1/PLA2G4D/PLA2G2A/PLD4	10
KEGG	hsa00240	Pyrimidine metabolism	12/2017	58/8135	0.8087	1	0.9486	UMPS/ENTPD4/TK2/NT5C1A/CAD/ENPP3/TYMS/ENTPD1/DHODH/NUDT2/UPP2/CANT1	12
KEGG	hsa04910	Insulin signaling pathway	30/2017	137/8135	0.8128	1	0.9486	PRKAB1/AKT2/SOCS4/IKBKB/PHKG2/TSC1/BAD/ARAF/EIF4EBP1/EIF4E2/CALML5/SOS2/PTPRF/PRKAG1/PIK3R3/PRKAB2/PDPK1/PYGM/SHC1/PPP1CB/RHOQ/INS/HRAS/KRAS/GRB2/PRKAA2/IRS1/CALML3/PCK2/AKT1	30
KEGG	hsa04922	Glucagon signaling pathway	23/2017	107/8135	0.8173	1	0.9486	PRKAB1/AKT2/PHKG2/PGAM2/PGAM4/LDHB/CPT1A/PLCB2/PDHA2/CALML5/SIRT1/GNAQ/PRKAG1/PRKAB2/GCGR/PYGM/PPP3CA/CREB3L1/PRKAA2/PPP3R1/CALML3/PCK2/AKT1	23
KEGG	hsa00410	beta-Alanine metabolism	6/2017	31/8135	0.8173	1	0.9486	CSAD/MLYCD/ACOX3/GAD1/EHHADH/ALDH3B2	6
KEGG	hsa05310	Asthma	6/2017	31/8135	0.8173	1	0.9486	TNF/MS4A2/IL4/IL10/CD40/FCER1A	6
KEGG	hsa00310	Lysine degradation	13/2017	63/8135	0.8186	1	0.9486	SETDB1/DLST/EHMT2/PHYKPL/SETMAR/KMT2D/PRDM16/EZH1/AADAT/TMLHE/PRDM7/EHHADH/EZH2	13
KEGG	hsa04350	TGF-beta signaling pathway	20/2017	94/8135	0.819	1	0.9486	SMAD4/TNF/RGMB/ID3/TFDP1/SMAD6/SP1/RBX1/NOG/INHBE/ID2/ACVR1C/THBS1/BMP8A/SMAD9/SMAD7/ACVR2B/TGIF2/BMP2/MYC	20
KEGG	hsa00500	Starch and sucrose metabolism	7/2017	36/8135	0.8251	1	0.9486	UGP2/SI/GBA3/ENPP3/AMY2B/PYGM/AMY2A	7
KEGG	hsa00512	Mucin type O-glycan biosynthesis	7/2017	36/8135	0.8251	1	0.9486	GCNT4/POC1B-GALNT4/GALNT6/GALNT11/GALNT15/GALNT18/GALNT12	7
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	7/2017	36/8135	0.8251	1	0.9486	SIRT1/NT5C1A/ENPP3/SIRT2/NNMT/NMRK2/NMRK1	7
KEGG	hsa04330	Notch signaling pathway	12/2017	59/8135	0.8275	1	0.9486	APH1A/LFNG/NUMBL/DTX3/DVL3/MFNG/DVL2/RBPJ/HES1/HDAC1/NUMB/DTX4	12
KEGG	hsa05140	Leishmaniasis	16/2017	77/8135	0.8291	1	0.9486	TNF/TAB1/C3/EEF1A1/FOS/EEF1A2/IL4/MAPK12/NFKBIB/PTPN6/RELA/JUN/MAPK11/IL10/FCGR3A/TRAF6	16
KEGG	hsa04931	Insulin resistance	23/2017	108/8135	0.8311	1	0.9486	PRKAB1/AKT2/IKBKB/TNF/CPT1A/SLC27A3/PTPRF/PRKAG1/PIK3R3/PRKAB2/PDPK1/PYGM/PPP1CB/RELA/GFPT1/INS/CREB3L1/MLX/PRKAA2/IRS1/MLXIPL/PCK2/AKT1	23
KEGG	hsa00120	Primary bile acid biosynthesis	3/2017	17/8135	0.8318	1	0.9486	SCP2/HSD3B7/CYP8B1	3
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	47/2017	212/8135	0.8357	1	0.9486	MIR29C/AKT2/IKBKE/GNAI2/KLF4/MIRLET7F1/STAT5A/MIR29B2/ATF6B/BAD/FOS/EIF4EBP1/GSTA2/RB1/ADCY7/FGF3/SOS2/CCND1/FGF6/GSTA4/PIK3R3/CACNA1C/KPNA1/MGST1/RELA/JUN/PTGES3/AHR/CHRNB4/CHRNB2/ARRB1/PAQR8/HRAS/KPNA4/ADRB2/RXRB/KRAS/CREB3L1/ADCY4/GRB2/HSP90AB1/MGST3/KPNA7/MYC/NR1I3/FGF4/AKT1	47
KEGG	hsa04966	Collecting duct acid secretion	5/2017	27/8135	0.8362	1	0.9486	TCIRG1/ATP6V1C2/ATP6V1B1/ATP6V1G3/ATP6V0E2	5
KEGG	hsa04215	Apoptosis - multiple species	6/2017	32/8135	0.8412	1	0.9486	BECN1/BAK1/DIABLO/BBC3/CASP8/CASP3	6
KEGG	hsa05031	Amphetamine addiction	14/2017	69/8135	0.8441	1	0.9486	ATF6B/FOS/CALML5/SIRT1/FOSB/GRIA2/CACNA1C/HDAC1/PPP1CB/JUN/PPP3CA/CREB3L1/PPP3R1/CALML3	14
KEGG	hsa04978	Mineral absorption	12/2017	60/8135	0.8449	1	0.9486	SLC46A1/MT1HL1/MT1A/MT1H/ATOX1/SLC8A2/ATP7A/ATP1A1/ATP2B2/HMOX1/SLC6A19/ATP2B3	12
KEGG	hsa05416	Viral myocarditis	12/2017	60/8135	0.8449	1	0.9486	CAV1/FYN/MYH6/CCND1/DAG1/CASP8/RAC2/CD28/CD40/PRF1/CD55/CASP3	12
KEGG	hsa05143	African trypanosomiasis	7/2017	37/8135	0.8469	1	0.9486	TNF/PLCB2/FASLG/GNAQ/IL10/IDO1/APOA1	7
KEGG	hsa04927	Cortisol synthesis and secretion	13/2017	65/8135	0.8522	1	0.9486	ATF6B/ORAI1/SP1/PDE8B/PLCB2/AGTR1/ADCY7/GNAQ/CACNA1C/POMC/PDE8A/CREB3L1/ADCY4	13
KEGG	hsa00380	Tryptophan metabolism	8/2017	42/8135	0.8527	1	0.9486	DLST/KMO/AADAT/TPH2/IDO1/IL4I1/EHHADH/AANAT	8
KEGG	hsa04217	Necroptosis	34/2017	159/8135	0.8648	1	0.9486	RIPK3/USP21/CHMP4A/TNF/RNF31/PPID/STAT5A/CHMP2A/SLC25A4/AIFM1/CHMP3/TNFRSF10B/STAT2/CHMP7/FASLG/TNFRSF10A/HMGB1/ZBP1/RBCK1/JAK3/SPATA2/SMPD1/IFNA21/PYGM/TICAM1/PLA2G4D/CASP8/SPATA2L/IFNA10/IFNA5/HSP90AB1/IFNA2/CHMP1A/TRAF5	34
KEGG	hsa04912	GnRH signaling pathway	19/2017	93/8135	0.8657	1	0.9486	MAP3K2/EGR1/PLCB2/ADCY7/PLD2/CALML5/SOS2/GNAQ/MAPK12/CACNA1C/PLA2G4D/JUN/MAPK11/HRAS/KRAS/ADCY4/GRB2/MAP3K1/CALML3	19
KEGG	hsa05330	Allograft rejection	7/2017	38/8135	0.8664	1	0.9486	TNF/FASLG/IL4/IL10/CD28/CD40/PRF1	7
KEGG	hsa01212	Fatty acid metabolism	11/2017	57/8135	0.87	1	0.9486	CPT1A/ACOX3/ELOVL1/SCP2/MCAT/HSD17B12/ACSBG1/ACADVL/CPT2/EHHADH/OXSM	11
KEGG	hsa00071	Fatty acid degradation	8/2017	43/8135	0.8707	1	0.9486	CPT1A/ACOX3/ACSBG1/ACADVL/CYP2U1/CPT2/EHHADH/ECI2	8
KEGG	hsa04520	Adherens junction	14/2017	71/8135	0.8731	1	0.9486	SMAD4/CTNNB1/FYN/PTPRF/PTPN6/LMO7/ERBB2/WASF2/TCF7L2/FARP2/TCF7/RAC2/CDH1/CTNNA2	14
KEGG	hsa04024	cAMP signaling pathway	48/2017	221/8135	0.8763	1	0.9486	AKT2/PTGER2/GNAI2/RRAS2/RAP1A/ORAI1/BAD/FOS/ACOX3/OXTR/VAV1/RAP1B/ADCY7/PLD2/CALML5/FXYD1/TIAM1/GRIA2/PPP1R12A/PIK3R3/CACNA1C/PDE4C/NFATC1/PDE4D/PPP1CB/CNGB1/RELA/JUN/GPHB5/SST/PLN/SSTR2/ADRB2/RAC2/POMC/ATP1A1/EDN2/ATP2B2/CREB3L1/TSHR/TNNI3/ADCY4/HTR1E/CALML3/ATP2B3/RAPGEF3/AKT1/PLCE1	48
KEGG	hsa00010	Glycolysis / Gluconeogenesis	13/2017	67/8135	0.8808	1	0.9486	PGAM2/PGAM4/LDHB/ALDOC/ACSS1/PDHA2/DLAT/ALDOB/TPI1/AKR1A1/ALDH3B2/GAPDHS/PCK2	13
KEGG	hsa04060	Cytokine-cytokine receptor interaction	65/2017	295/8135	0.8833	1	0.9486	TNF/IL23A/TNFRSF14/CD70/IL2RB/IL21R/CSF1/EDA/IL27RA/EDAR/TNFRSF10D/CXCL13/IL17B/IL6R/TNFRSF10B/CX3CR1/IL11RA/CLCF1/IL4R/EDA2R/CCR7/IL16/FASLG/TNFRSF10A/LEP/IL4/CCL17/CCL26/ACKR3/INHBE/TNFRSF25/CSF1R/ACVRL1/CRLF2/IFNA21/IL7/ACVR1C/IL6ST/TNFSF15/TNFRSF17/CCR4/IL10/CSF3/IL17D/BMP8A/TNFRSF13B/CCR3/IL21/IL17A/IL20RA/GDF9/IL5RA/IL10RB/IFNA10/CCL27/IL22RA1/CD40/IFNA5/CCL16/IL36A/GDF2/ACVR2B/IFNA2/BMP2/CXCR3	65
KEGG	hsa00531	Glycosaminoglycan degradation	3/2017	19/8135	0.8851	1	0.9486	IDUA/SGSH/HYAL1	3
KEGG	hsa04066	HIF-1 signaling pathway	22/2017	109/8135	0.8935	1	0.9486	AKT2/LDHB/ALDOC/IGF1/PLCG1/IL6R/EIF4EBP1/EIF4E2/TFRC/PDHA2/CUL2/RBX1/PIK3R3/ALDOB/ERBB2/EGLN2/HIF1A/RELA/INS/HMOX1/AKT1/CDKN1A	22
KEGG	hsa04728	Dopaminergic synapse	27/2017	132/8135	0.8992	1	0.9486	AKT2/PPP2R2D/GNAI2/ATF6B/FOS/PLCB2/KIF5B/PPP2R5D/CALML5/GNAQ/MAPK12/GRIA2/CACNA1C/PPP1CB/MAPK11/GNAL/GNG7/ARRB1/PPP3CA/PPP2R2A/CREB3L1/PPP2R5A/CALML3/KIF5A/PPP2R3B/PPP2R2C/AKT1	27
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/2017	25/8135	0.9002	1	0.9486	PLA2G6/ACOX3/PLA2G4D/PLA2G2A	4
KEGG	hsa04612	Antigen processing and presentation	15/2017	78/8135	0.9018	1	0.9486	NFYC/TNF/RFX5/KIR2DS4/HSPA1L/KLRD1/KIR2DS1/HSPA2/NFYA/KIR2DS2/HSPA5/HSP90AB1/PSME3/KIR3DL2/TAP1	15
KEGG	hsa05110	Vibrio cholerae infection	9/2017	50/8135	0.9036	1	0.9486	TCIRG1/PLCG1/ATP6V1C2/ATP6V1B1/TJP2/ATP6V1G3/ATP6V0B/ARF1/ATP6V0E2	9
KEGG	hsa01200	Carbon metabolism	23/2017	115/8135	0.907	1	0.9486	PGAM2/PGAM4/DLST/ALDOC/ACSS1/ACOX3/CS/PDHA2/DLAT/SUCLG1/OGDH/IDH3B/ALDOB/ME3/SHMT1/GOT2/TPI1/AGXT/GLDC/ACO1/MDH2/TKTL1/TALDO1	23
KEGG	hsa04611	Platelet activation	25/2017	124/8135	0.9071	1	0.9486	AKT2/GNAI2/RAP1A/MYL12B/ARHGEF1/ORAI1/PLCB2/RAP1B/FYN/ADCY7/GNAQ/MAPK12/PPP1R12A/PIK3R3/PIK3R6/PPP1CB/PLA2G4D/MAPK11/LCP2/PIK3R5/ADCY4/F2/COL1A2/BTK/AKT1	25
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	19/2017	97/8135	0.9082	1	0.9486	AKT2/PLA2G6/PLCG1/CFL1/VAV1/PLD2/PIK3R3/ARPC1B/WASF2/DOCK1/PIP5K1A/PLA2G4D/FCGR3A/ACTR3C/RAC2/ASAP1/AMPH/DNM2/AKT1	19
KEGG	hsa04730	Long-term depression	11/2017	60/8135	0.9092	1	0.9486	GNAI2/IGF1/ARAF/PLCB2/GNAQ/PPP1R17/GRIA2/PLA2G4D/HRAS/KRAS/NOS1	11
KEGG	hsa03018	RNA degradation	15/2017	79/8135	0.9119	1	0.9486	EXOSC2/EDC3/TOB2/PABPC3/PAN2/CNOT3/EDC4/LSM5/EXOSC8/PABPC1L2A/DIS3L/LSM3/EXOSC5/SKIV2L/PNPT1	15
KEGG	hsa04216	Ferroptosis	7/2017	41/8135	0.913	1	0.9486	LPCAT3/PCBP2/TFRC/TP53/HMOX1/NCOA4/MAP1LC3C	7
KEGG	hsa04270	Vascular smooth muscle contraction	27/2017	134/8135	0.915	1	0.9486	PLA2G6/KCNMB1/MYH11/NPR2/ARHGEF1/ARAF/PLCB2/AGTR1/ADCY7/CALML5/GNAQ/MYL6B/PPP1R12A/CACNA1C/MYH14/PPP1CB/PLA2G4D/PPP1R12C/PLA2G2A/ADRA1D/RAMP3/ARHGEF11/EDN2/ADRA1B/ADCY4/NPPB/CALML3	27
KEGG	hsa04923	Regulation of lipolysis in adipocytes	10/2017	56/8135	0.9176	1	0.9486	AKT2/GNAI2/ADCY7/PIK3R3/INS/ADRB2/TSHR/ADCY4/IRS1/AKT1	10
KEGG	hsa04918	Thyroid hormone synthesis	14/2017	75/8135	0.9181	1	0.9486	ATF6B/PLCB2/TTF2/ADCY7/GNAQ/DUOX2/TTF1/GPX6/ATP1A1/CREB3L1/TSHR/HSPA5/ADCY4/ASGR1	14
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	12/2017	66/8135	0.9222	1	0.9486	LARS2/HARS2/YARS2/CARS2/DARS2/MARS2/FARSA/SARS2/NARS2/MTFMT/TARS2/AARS2	12
KEGG	hsa04973	Carbohydrate digestion and absorption	8/2017	47/8135	0.9254	1	0.9486	AKT2/SI/PLCB2/PIK3R3/AMY2B/ATP1A1/AMY2A/AKT1	8
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/2017	27/8135	0.9306	1	0.9486	ST3GAL3/ST8SIA1/B3GNT2/FUT1	4
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/2017	27/8135	0.9306	1	0.9486	ACOX3/ELOVL1/SCP2/HSD17B12	4
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	21/2017	109/8135	0.9308	1	0.9486	WDR3/NOP56/EMG1/NXF1/RIOK1/PWP2/NOL6/POP1/GNL3/LSG1/RBM28/DKC1/GNL3L/MDN1/NAT10/GNL2/NOB1/UTP6/RPP38/HEATR1/SBDS	21
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/2017	77/8135	0.9351	1	0.9486	CTNNB1/CACNB1/ITGB8/ITGA10/CACNA1C/SLC8A2/CACNG4/ITGA5/TCF7L2/DAG1/CACNG7/TCF7/ITGAV/CTNNA2	14
KEGG	hsa00230	Purine metabolism	25/2017	128/8135	0.9354	1	0.9486	ENTPD4/NPR2/AK5/ITPA/FHIT/PDE8B/ADCY7/NT5C1A/ENPP3/PPAT/PDE7B/PDE4C/PDE4D/PFAS/GMPR2/ADA/ENTPD1/NUDT9/PDE8A/LACC1/NUDT2/ATIC/ADCY4/CANT1/AK2	25
KEGG	hsa00480	Glutathione metabolism	10/2017	58/8135	0.9368	1	0.9486	GGT7/GGT5/GSTA2/GSTA4/CHAC1/GSTK1/MGST1/CHAC2/GPX6/MGST3	10
KEGG	hsa00340	Histidine metabolism	3/2017	22/8135	0.937	1	0.9486	FTCD/HDC/ALDH3B2	3
KEGG	hsa00920	Sulfur metabolism	1/2017	10/8135	0.9422	1	0.9486	SUOX	1
KEGG	hsa04929	GnRH secretion	11/2017	64/8135	0.9456	1	0.9486	AKT2/KISS1/PLCB2/GNAQ/PIK3R3/CACNA1C/ARRB1/HRAS/KRAS/KCNN4/AKT1	11
KEGG	hsa05152	Tuberculosis	36/2017	180/8135	0.9472	1	0.9486	RAB7A/AKT2/NFYC/TIRAP/TNF/IL23A/CASP10/TCIRG1/BAD/C3/CALML5/NOD2/MAPK12/LSP1/RFX5/IFNA21/RELA/MAPK11/IL10/ATP6V0B/FCGR3A/PPP3CA/CASP8/RAB5C/KSR1/NFYA/IL10RB/IFNA10/IFNA5/MRC1/TRAF6/IFNA2/PPP3R1/CALML3/CASP3/AKT1	36
KEGG	hsa00910	Nitrogen metabolism	2/2017	17/8135	0.9482	1	0.9486	CA5B/CA1	2
KEGG	hsa04744	Phototransduction	4/2017	29/8135	0.9524	1	0.9486	CALML5/GNAT2/CNGB1/CALML3	4
KEGG	hsa05033	Nicotine addiction	6/2017	40/8135	0.9544	1	0.9486	GABRB3/GABRD/GABRA3/GRIA2/CHRNB2/GABRP	6
KEGG	hsa00590	Arachidonic acid metabolism	10/2017	61/8135	0.9583	1	0.9486	AKR1C3/PLA2G6/GGT5/CYP2U1/PLA2G4D/PLA2G2A/CBR1/PTGES3/GPX6/PTGES	10
KEGG	hsa04971	Gastric acid secretion	13/2017	76/8135	0.9595	1	0.9486	CHRM3/GNAI2/PLCB2/ADCY7/CALML5/GNAQ/CCKBR/KCNJ2/SST/SSTR2/ATP1A1/ADCY4/CALML3	13
KEGG	hsa04930	Type II diabetes mellitus	7/2017	46/8135	0.9599	1	0.9486	SOCS4/IKBKB/TNF/PIK3R3/CACNA1C/INS/IRS1	7
KEGG	hsa00030	Pentose phosphate pathway	4/2017	30/8135	0.9608	1	0.9486	ALDOC/ALDOB/TKTL1/TALDO1	4
KEGG	hsa05202	Transcriptional misregulation in cancer	38/2017	193/8135	0.9623	1	0.9486	FEV/IL2RB/PRCC/BAK1/IGF1/FUS/MEN1/CCND2/SIX4/SP1/HHEX/SLC45A3/CDK9/DUSP6/TRAF1/RARA/CSF1R/PML/HDAC1/MDM2/ID2/LDB1/TP53/RELA/GADD45G/GADD45A/CDKN2C/RXRB/CD40/SS18L1/DDX5/MYC/HOXA9/BCL11B/MAF/CCNT2/CDKN1A/NUPR1	38
KEGG	hsa00350	Tyrosine metabolism	5/2017	36/8135	0.9641	1	0.9486	GOT2/IL4I1/ALDH3B2/PNMT/DBH	5
KEGG	hsa05332	Graft-versus-host disease	6/2017	42/8135	0.9676	1	0.9486	TNF/FASLG/KLRD1/CD28/PRF1/KIR3DL2	6
KEGG	hsa00052	Galactose metabolism	4/2017	31/8135	0.9677	1	0.9486	UGP2/SI/GALT/GLA	4
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	17/2017	98/8135	0.9707	1	0.9486	PLA2G6/PTGER4/PTGER2/IGF1/PLCG1/PLCB2/ADCY7/CALML5/GNAQ/MAPK12/PIK3R3/PPP1CB/PLA2G4D/MAPK11/ADCY4/TRPV2/CALML3	17
KEGG	hsa04925	Aldosterone synthesis and secretion	17/2017	98/8135	0.9707	1	0.9486	ATF6B/ORAI1/PLCB2/AGTR1/ADCY7/CALML5/GNAQ/CACNA1C/DAGLB/PRKD2/POMC/ATP1A1/ATP2B2/CREB3L1/ADCY4/CALML3/ATP2B3	17
KEGG	hsa00280	Valine, leucine and isoleucine degradation	7/2017	48/8135	0.9711	1	0.9486	AGXT2/DBT/IVD/HMGCL/IL4I1/BCAT2/EHHADH	7
KEGG	hsa00860	Porphyrin metabolism	6/2017	43/8135	0.9728	1	0.9486	COX15/BLVRA/COX10/FECH/ALAS1/HMOX1	6
KEGG	hsa04940	Type I diabetes mellitus	6/2017	43/8135	0.9728	1	0.9486	TNF/FASLG/GAD1/INS/CD28/PRF1	6
KEGG	hsa04975	Fat digestion and absorption	6/2017	43/8135	0.9728	1	0.9486	PNLIPRP2/CLPS/PLA2G2A/GOT2/APOB/APOA1	6
KEGG	hsa00100	Steroid biosynthesis	2/2017	20/8135	0.9747	1	0.9486	NSDHL/LSS	2
KEGG	hsa04672	Intestinal immune network for IgA production	7/2017	49/8135	0.9755	1	0.9486	MAP3K14/IL4/TNFRSF17/IL10/TNFRSF13B/CD28/CD40	7
KEGG	hsa05030	Cocaine addiction	7/2017	49/8135	0.9755	1	0.9486	GNAI2/ATF6B/FOSB/GRIA2/RELA/JUN/CREB3L1	7
KEGG	hsa01232	Nucleotide metabolism	14/2017	85/8135	0.9763	1	0.9486	ENTPD4/AK5/ITPA/TK2/NT5C1A/ENPP3/TYMS/GMPR2/ADA/ENTPD1/LACC1/UPP2/CANT1/AK2	14
KEGG	hsa00062	Fatty acid elongation	3/2017	27/8135	0.9783	1	0.9486	ELOVL1/HSD17B12/THEM5	3
KEGG	hsa04911	Insulin secretion	14/2017	86/8135	0.9793	1	0.9486	KCNMB1/CHRM3/ATF6B/PLCB2/ADCY7/GNAQ/CACNA1C/INS/RAB3A/ATP1A1/FFAR1/CREB3L1/ADCY4/KCNN4	14
KEGG	hsa00650	Butanoate metabolism	3/2017	28/8135	0.9825	1	0.9486	HMGCL/GAD1/EHHADH	3
KEGG	hsa04913	Ovarian steroidogenesis	7/2017	51/8135	0.9826	1	0.9486	AKR1C3/IGF1/HSD17B1/ADCY7/PLA2G4D/INS/ADCY4	7
KEGG	hsa04540	Gap junction	14/2017	88/8135	0.9842	1	0.9486	TUBA3C/MAP3K2/GNAI2/CSNK1D/PLCB2/ADCY7/SOS2/GNAQ/PDGFC/TUBA3E/HRAS/KRAS/ADCY4/GRB2	14
KEGG	hsa00220	Arginine biosynthesis	2/2017	22/8135	0.9845	1	0.9486	GOT2/NOS1	2
KEGG	hsa00591	Linoleic acid metabolism	3/2017	29/8135	0.986	1	0.9486	PLA2G6/PLA2G4D/PLA2G2A	3
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/2017	23/8135	0.9879	1	0.9486	ATP1A1/PCK2	2
KEGG	hsa04610	Complement and coagulation cascades	13/2017	85/8135	0.9882	1	0.9486	C3/KLKB1/A2M/VSIG4/PROC/F3/C1QC/F2/CD55/CFHR2/F7/C8G/CR2	13
KEGG	hsa05032	Morphine addiction	14/2017	91/8135	0.9897	1	0.9486	GNAI2/GABRB3/GABRD/PDE8B/ADCY7/GABRA3/PDE7B/PDE4C/PDE4D/GNG7/ARRB1/PDE8A/ADCY4/GABRP	14
KEGG	hsa04742	Taste transduction	13/2017	86/8135	0.9898	1	0.9486	TAS2R4/CHRM3/TAS2R5/TAS2R3/PLCB2/GABRA3/TAS2R13/CACNA1C/TAS2R20/TAS2R50/ADCY4/HTR1E/TAS2R41	13
KEGG	hsa05206	MicroRNAs in cancer	60/2017	310/8135	0.9914	1	0.9486	MIR29C/IKBKB/MIR200B/MIRLET7F1/MIR30C2/MIR28/BAK1/MIR29B2/CCND2/PLCG1/ST14/UBE2I/MIR330/MIR30E/MIR205/SLC45A3/MIR26A2/CDC25B/RECK/SIRT1/SOS2/CCND1/MIR128-1/MIR19B2/MIR181B1/PIK3R3/MIR7-2/APC2/MIR34C/MIR128-2/HDAC1/MDM2/MIR27B/ERBB2/SHC1/TP53/ITGA5/MIR16-2/THBS1/BMF/EFNA2/CDKN2A/MIR27A/HRAS/KRAS/MIR375/MIR34A/GRB2/MIR150/MCL1/HMOX1/MIR96/ABCB1/CCNE1/MYC/IRS1/E2F2/CASP3/EZH2/CDKN1A	60
KEGG	hsa04360	Axon guidance	32/2017	182/8135	0.9927	1	0.9486	PLXNA4/EPHA2/RYK/GNAI2/MYL12B/NTN1/SEMA3A/PLCG1/SEMA4C/CFL1/EPHB6/FYN/TRPC3/PIK3R3/PDPK1/WNT4/PLXNB2/ABLIM1/EPHB1/PLXNA1/SEMA4D/L1CAM/PPP3CA/EFNA2/HRAS/RAC2/KRAS/EFNB3/LRRC4C/EPHA3/PPP3R1/SMO	32
KEGG	hsa04727	GABAergic synapse	13/2017	89/8135	0.9935	1	0.9486	GNAI2/GABRB3/SLC6A11/GABRD/ADCY7/GABRA3/CACNA1C/GNG7/GAD1/SLC6A12/ADCY4/GPHN/GABRP	13
KEGG	hsa04020	Calcium signaling pathway	44/2017	240/8135	0.9938	1	0.9486	PHKG2/P2RX7/CHRM3/ORAI1/SLC25A4/PLCG1/OXTR/PLCB2/PLCD4/AGTR1/ADCY7/CALML5/FGF3/GNAQ/FGF6/CACNA1C/CCKBR/CHRM5/SLC8A2/ERBB2/GNAL/CYSLTR2/ADRA1D/PPP3CA/PDGFC/VEGFC/PLN/CASQ2/ADRB2/FGF1/HGF/ITPKB/TNNC2/ATP2B2/LTB4R2/MCOLN3/ADRA1B/ADCY4/NOS1/PPP3R1/CALML3/ATP2B3/FGF4/PLCE1	44
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	9/2017	69/8135	0.9948	1	0.9486	GSTA2/GSTA4/GSTK1/MGST1/CBR1/CYP3A43/NAT1/SULT2A1/MGST3	9
KEGG	hsa04145	Phagosome	25/2017	152/8135	0.9953	1	0.9486	RAB7A/TUBA3C/HGS/TCIRG1/C3/TFRC/ATP6V1C2/ATP6V1B1/DYNC1H1/RILP/ITGA5/ATP6V1G3/ATP6V0B/FCGR3A/THBS1/RAB5C/TUBA3E/DYNC1I1/ITGAV/MRC1/SFTPD/NOS1/TAP1/COLEC12/ATP6V0E2	25
KEGG	hsa00040	Pentose and glucuronate interconversions	3/2017	34/8135	0.9955	1	0.9486	UGP2/DCXR/AKR1A1	3
KEGG	hsa04972	Pancreatic secretion	15/2017	102/8135	0.9956	1	0.9486	CTRL/CHRM3/RAP1A/PLCB2/RAP1B/ADCY7/GNAQ/PNLIPRP2/AMY2B/PLA2G2A/ATP1A1/AMY2A/ATP2B2/ADCY4/ATP2B3	15
KEGG	hsa04514	Cell adhesion molecules	24/2017	149/8135	0.9964	1	0.9486	SELPLG/NCAM1/SPN/TIGIT/ITGB8/PTPRF/SDC1/PECAM1/SIGLEC1/CLDN24/CLDN10/CLDN15/L1CAM/CADM3/CDH15/CDH4/CD28/ITGAV/NRXN2/CD40/LRRC4C/CD99L2/NRXN3/CDH1	24
KEGG	hsa05323	Rheumatoid arthritis	13/2017	93/8135	0.9965	1	0.9486	TNF/IL23A/CSF1/TCIRG1/FOS/ATP6V1C2/ATP6V1B1/JUN/ATP6V1G3/ATP6V0B/IL17A/CD28/ATP6V0E2	13
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/2017	78/8135	0.9972	1	0.9486	GSTA2/AKR7A3/GSTA4/GSTK1/MGST1/CBR1/AKR7A2/SULT2A1/MGST3/ALDH3B2	10
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/2017	29/8135	0.9973	1	0.9486	FAT4/MOB1A	2
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/2017	30/8135	0.9979	1	0.9486	MIOX/AKR1A1	2
KEGG	hsa00983	Drug metabolism - other enzymes	10/2017	80/8135	0.998	1	0.9486	UMPS/ITPA/GSTA2/TK2/GSTA4/MGST1/CES2/NAT1/UPP2/MGST3	10
KEGG	hsa04713	Circadian entrainment	13/2017	97/8135	0.9982	1	0.9486	GNAI2/FOS/PLCB2/ADCY7/CALML5/GNAQ/GRIA2/CACNA1C/GNG7/ADCY4/NOS1/CALML3/MTNR1B	13
KEGG	hsa00330	Arginine and proline metabolism	5/2017	51/8135	0.9982	1	0.9486	P4HA2/PYCR2/GOT2/NOS1/L3HYPDH	5
KEGG	hsa04724	Glutamatergic synapse	16/2017	114/8135	0.9984	1	0.9486	GNAI2/PLCB2/ADCY7/PLD2/GNAQ/HOMER2/GRIA2/HOMER3/CACNA1C/SHANK3/PLA2G4D/GNG7/PPP3CA/ADCY4/SLC1A2/PPP3R1	16
KEGG	hsa00982	Drug metabolism - cytochrome P450	8/2017	72/8135	0.9989	1	0.9486	GSTA2/FMO4/FMO3/GSTA4/GSTK1/MGST1/MGST3/ALDH3B2	8
KEGG	hsa05150	Staphylococcus aureus infection	12/2017	96/8135	0.9991	1	0.9486	SELPLG/C3/KRT38/KRT34/KRT9/KRT10/IL10/FCGR3A/KRT33B/C1QC/KRT12/KRT14	12
KEGG	hsa04726	Serotonergic synapse	15/2017	115/8135	0.9994	1	0.9486	GNAI2/GABRB3/ARAF/PLCB2/GNAQ/CACNA1C/PLA2G4D/TPH2/GNG7/HRAS/DUSP1/KRAS/HTR1E/CASP3/RAPGEF3	15
KEGG	hsa04080	Neuroactive ligand-receptor interaction	62/2017	353/8135	0.9997	1	0.9486	PYY/NPFF/PTGER4/TAC4/PTGER2/P2RX7/CHRM3/GABRB3/INSL3/RLN2/C3/CHRNA10/TRH/UCN/KISS1/GABRD/HRH4/OXTR/AGTR1/ADRA2B/LEP/GHRH/MLN/GABRA3/NMU/GRIA2/GCGR/CCKBR/CHRM5/NTSR2/ADRA2A/PTGDR/CYSLTR2/CHRNB4/CHRNB2/ADRA1D/NTS/CNR2/GPHB5/SST/CHRNE/S1PR1/LPAR2/SSTR2/SSTR3/ADRB2/GPR156/POMC/EDN2/NMUR1/TSHR/LTB4R2/ADRA1B/HTR1E/F2/VIPR1/CHRNA5/AGTR2/MTNR1B/APLNR/GABRP/HCRTR1	62
KEGG	hsa04976	Bile secretion	9/2017	89/8135	0.9999	1	0.9486	ABCC2/SLC4A5/ADCY7/HMGCR/ATP1A1/ADCY4/SULT2A1/ABCB1/SLC51B	9
KEGG	hsa00830	Retinol metabolism	5/2017	68/8135	1	1	0.9486	DHRS4L2/RDH11/RDH12/RETSAT/PNPLA4	5
KEGG	hsa00140	Steroid hormone biosynthesis	4/2017	61/8135	1	1	0.9486	AKR1C3/HSD17B1/HSD17B12/SRD5A3	4
KEGG	hsa05034	Alcoholism	20/2017	187/8135	1	1	0.9486	GNAI2/ATF6B/ARAF/SLC29A3/CALML5/FOSB/SOS2/HDAC8/HDAC1/SHC1/PPP1CB/GNG7/HDAC7/HRAS/SLC29A2/KRAS/CREB3L1/GRB2/CALML3/PKIA	20
KEGG	hsa05322	Systemic lupus erythematosus	11/2017	136/8135	1	1	0.9486	TNF/C3/SNRPD3/TRIM21/IL10/SNRPB/FCGR3A/C1QC/CD28/CD40/C8G	11
KEGG	hsa04613	Neutrophil extracellular trap formation	19/2017	190/8135	1	1	0.9486	AKT2/SELPLG/C3/SLC25A4/PLCG1/PLCB2/HMGB1/MAPK12/HDAC8/PIK3R3/HDAC1/RELA/MAPK11/FCGR3A/AGER/HDAC7/SIGLEC9/RAC2/AKT1	19
KEGG	hsa04740	Olfactory transduction	53/2017	440/8135	1	1	0.9486	OR2T11/OR2D3/OR2T34/OR2AE1/OR2M5/OR13G1/OR56A3/OR2L3/CALML5/OR8H3/OR56B4/OR7G2/OR51B6/OR2L5/OR52H1/OR5B21/OR4D10/OR4S2/OR52K1/OR8G5/OR10K2/OR51J1/OR2L8/SLC8A2/OR10W1/OR11H1/CNGB1/OR5J2/OR2A42/OR7A5/OR10G4/GNAL/GNG7/ARRB1/OR13A1/OR4C11/OR4D1/OR2AK2/OR1E1/OR8K5/OR51B4/OR5B3/OR1L1/OR13H1/OR2AG1/OR4N5/OR52E6/OR1J1/OR52L1/OR6Y1/OR4P4/CALML3/OR7A17	53