ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05417	Lipid and atherosclerosis	208/6408	215/8135	1.342e-14	4.482e-12	1.723e-12	IL12A/IFNA2/IFNB1/MMP3/CYP2A7/IFNA1/IFNA13/NOX1/BAD/AKT2/CAMK2G/CASP9/PLCB2/ATF4/RAC1/MAPK14/PIK3CB/CD40/RHOA/PPP3R2/ARHGEF1/VAV1/HSPA5/MYD88/CALML6/HSPA4/IKBKG/HSP90B1/NCF4/TBK1/NFATC1/NCF1/HSPA6/PIK3CD/IRAK1/NCF2/TNFRSF1A/RXRA/MAPK1/AKT1/AKT3/POU2F2/PPP3CB/MAPK9/PLCB4/TICAM1/NOS3/FAS/MAPK3/CASP3/EIF2S1/JAK2/PIK3R1/CASP8/XBP1/CALM2/POU2F1/IL1B/CD14/IRAK4/TRAF6/MAPK11/ABCA1/PYCARD/TRAF2/MIB1/TIRAP/IRF3/NFKBIA/BAX/TNFRSF10B/MAPK13/BID/HRAS/PIK3R2/BCL2L1/IKBKB/PIK3CA/MAP3K5/TAB2/RAP1A/TNF/HSPA8/LY96/DDIT3/MAPK12/HSPA1L/CYP2J2/ATF6/VAV2/CASP1/CXCL1/CALM1/HSPA1A/IRF7/ICAM1/CDC42/PLCB3/CD36/LYN/TNFSF10/SELP/JUN/MAP2K4/LDLR/APOA1/EIF2AK3/ROCK2/RXRB/HSPD1/MAP3K7/MAP2K6/PTK2/RELA/CAMK2B/CYBA/TAB1/IFNA8/NLRP3/ABCG1/HSP90AA1/NFKB1/NFE2L2/CYBB/TRAF3/IKBKE/PPP3CA/RAP1B/CYP1A1/APAF1/MAP2K7/CXCL3/CALML4/SELE/TLR2/MMP9/NFATC2/CALML5/CYCS/ITPR1/APOB/KRAS/MIB2/SOD2/FOS/TNFRSF10A/HSPA1B/TICAM2/PLCG1/MAPK8/APOA4/AGER/CYP2C9/CYP2B6/IL12B/CD40LG/TLR6/ERN1/CALM3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/SRC/CALML3/HSP90AB1/CAMK2D/CCL5/STAT3/CASP7/CYP2C8/TP53/PPP3CC/CAMK2A/IL18/CASP6/PLCB1/MAP2K3/CYP2A6/PRKCA/NRAS/BCL2/CHUK/FASLG/MMP1/PIK3R3/TANK/PDPK1/NFATC3/PPP3R1/MAPK10/CCL2/TLR4/VCAM1/IFNA17/RXRG/CCL3/CCL3L1/CCL3L3/IL6/PPARG/POU2F3/HSPA2/GSK3B	208
KEGG	hsa05169	Epstein-Barr virus infection	194/6408	202/8135	1.441e-12	2.407e-10	9.253e-11	IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/PSMD6/USP7/BCL2L11/AKT2/TAPBP/ENTPD3/CASP9/E2F1/MDM2/RAC1/GADD45B/MAPK14/PIK3CB/CD40/BTK/NFKBIB/HDAC1/SYK/PSMC1/PSMC4/HLA-B/HLA-C/MYD88/TAP1/RIPK1/CCND1/PSMD1/IKBKG/SAP30L/TYK2/NFKBIE/TBK1/PIK3CD/IRAK1/IFNAR1/PSMD12/AKT1/PSMD2/TRADD/PSMD13/AKT3/JAK3/TNFAIP3/PSMD7/ITGAL/FADD/HLA-A/SNW1/MAPK9/FAS/CASP3/RELB/PSMD4/PLCG2/CCND3/PIK3R1/ADRM1/CASP8/CDKN1A/PSMC6/DDB2/PSMC2/IRAK4/TRAF6/MAPK11/TRAF2/MAVS/BAK1/CD58/IRF3/NFKBIA/BAX/MAPK13/HDAC2/BID/PIK3R2/PSMC5/IKBKB/CIR1/PSMD11/PIK3CA/TAB2/IRF9/TNF/MAPK12/ENTPD1/HLA-G/POLK/IRF7/ICAM1/LYN/RBPJL/JUN/HLA-F/MAP2K4/NFKB2/CDKN1B/STAT1/HES1/MAP3K7/HLA-DMB/STAT2/MAP2K6/RELA/CD3D/TAB1/TAP2/DDX58/IFNA8/PSMD8/NFKB1/PSMD14/CCNA2/TRAF3/IKBKE/NCOR2/E2F3/GADD45A/APAF1/MAP2K7/VIM/TLR2/SIN3A/GADD45G/CCND2/CYCS/EIF2AK2/CDK2/HLA-DMA/MAPK8/B2M/CD44/RBPJ/IFNAR2/CCNE2/ISG15/CD3G/PSMD3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PSMC3/HLA-DRA/IFNA16/CALR/CCNE1/MAP3K14/STAT3/CDK4/CD19/HLA-DPA1/TP53/RB1/FCER2/OAS1/PDIA3/RUNX3/SKP2/HLA-DOA/HLA-DQB1/TRAF5/OAS3/MAP2K3/BCL2/CHUK/CDK6/JAK1/PIK3R3/E2F2/MAPK10/SAP30/CD3E/HLA-DOB/BLNK/IFNA17/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/OAS2/HLA-DRB1/HLA-DRB4/IL6/NEDD4/MYC	194
KEGG	hsa05132	Salmonella infection	234/6408	249/8135	1.488e-11	1.656e-09	6.368e-10	PIK3C3/ARL8A/PAK1/VPS33A/CYTH1/AKT2/VPS41/ACTG1/ACTR10/TUBA1A/TUBA1C/RAC1/MAPK14/PIK3CB/RHOA/PLEKHM1/ARPC4/ARPC5/NCKAP1L/DYNLL1/DYNLL2/DYNLRB1/VPS39/RHOG/MYD88/NLRC4/ACTR1A/RIPK1/MAP2K2/DYNC1LI1/ARPC1A/KLC1/IKBKG/GAPDH/HSP90B1/MLKL/RIPK3/PIK3C2G/ARPC1B/ACTR3B/CYFIP2/GSDMD/ARPC2/PIK3CD/IRAK1/EXOC7/ELMO2/TNFRSF1A/MAPK1/TUBAL3/CASP4/VPS18/TLR9/ACTR3/VPS11/FLNC/RAB5A/AKT1/WASL/TRADD/CYFIP1/CYTH4/AKT3/TXN/ARF1/DYNLT3/FADD/DYNLT1/TUBA3D/TUBA3E/TUBA4A/DYNC1LI2/MAPK9/ARPC5L/ARPC3/TUBA3C/RAF1/TUBB1/MAPK3/VPS16/CSE1L/CASP3/RRAS/NOD1/FYCO1/MYL12A/MYL12B/STX10/PLEKHM2/DCTN6/CASP8/IL1B/S100A10/DYNC1H1/CD14/IRAK4/TRAF6/DCTN1/MAPK11/PYCARD/TUBA1B/MYLPF/TRAF2/SNX33/DCTN2/TIRAP/BAK1/ACTR1B/FHOD1/NFKBIA/BAX/BIRC2/ACTB/TNFRSF10B/MAPK13/RALA/HRAS/IKBKB/KIF5C/PIK3CA/TLR5/TAB2/TNF/ARL8B/LY96/MAPK12/PFN4/CASP1/ANXA2/ARF6/CDC42/NAIP/KIF5B/DYNC1I2/TNFSF10/TCF7/MYL10/DCTN3/JUN/MAP2K4/PTPRC/ROCK2/RAB5B/MAP3K7/MAP2K6/PKN1/RELA/DNM2/PFN1/MAP2K1/RAB7A/TAB1/TAB3/ABI1/DCTN5/RIPK2/NLRP3/TXN2/HSP90AA1/CYTH3/NFKB1/CASP5/EXOC4/RAB9A/MAP2K7/TCF7L2/KLC4/TLR2/KPNA1/SKP1/M6PR/TUBA8/RHOB/CYCS/PODXL/RILP/RAB7B/FLNB/TUBB6/FOS/DCTN4/TNFRSF10A/ELMO1/MAPK8/RAB5C/DYNC2LI1/ACBD3/FLNA/TLR6/WASF3/CYTH2/KLC3/HSP90AB1/PIK3CG/MYL9/CASP7/PIK3C2A/AHNAK2/TUBB/SNX18/IL18/EXOC2/SNX9/BIRC3/KPNA4/ACTR2/CTNNB1/MYL7/MYO6/TUBB3/MAP2K3/NCKAP1/GCC2/BCL2/CHUK/AHNAK/RHOH/KPNA3/PAK3/MAPK10/PFN2/TLR4/EXOC5/MYL5/RAB9B/RPS3/DYNC2H1/FBXO22/KLC2/IL6/KIF5A/DYNC1I1/MYC/PIK3C2B	234
KEGG	hsa05162	Measles	136/6408	139/8135	2.822e-11	2.356e-09	9.059e-10	IL12A/IFNA2/IFNB1/IL2/CLEC4M/IFNA1/IFNA13/BAD/ADAR/AKT2/CD209/CASP9/PIK3CB/IL2RG/NFKBIB/STAT5B/MYD88/MSN/CCND1/STAT5A/IKBKG/TYK2/CSNK2B/TBK1/MX2/HSPA6/PIK3CD/IRAK1/CD46/IFNAR1/TLR9/AKT1/TRADD/AKT3/JAK3/TNFAIP3/FADD/MAPK9/FAS/RCHY1/CASP3/EIF2S1/CCND3/PIK3R1/CASP8/IL2RA/IL1B/IRAK4/TRAF6/MAVS/BAK1/IRF3/NFKBIA/BAX/BBC3/BID/PIK3R2/BCL2L1/IKBKB/PIK3CA/TAB2/IRF9/HSPA8/HSPA1L/EIF2AK1/EIF3H/HSPA1A/IRF7/CSNK2A2/JUN/CDKN1B/STAT1/EIF2AK3/MAP3K7/STAT2/RELA/CD3D/CSNK2A1/CBLB/DDX58/IFNA8/NFKB1/TRAF3/IKBKE/RAB9A/APAF1/IFIH1/TLR2/CCND2/CYCS/EIF2AK2/CDK2/TLR7/FOS/HSPA1B/MAPK8/FCGR2B/IL12B/IFNAR2/CCNE2/CD3G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/MX1/IFNA16/CCNE1/STAT3/CDK4/TP53/OAS1/OAS3/IL2RB/CD28/BCL2/CHUK/CDK6/JAK1/FASLG/PIK3R3/SLAMF1/MAPK10/TLR4/CD3E/RAB9B/IFNA17/OAS2/IL6/EIF2AK4/HSPA2/GSK3B/IL1A	136
KEGG	hsa04151	PI3K-Akt signaling pathway	323/6408	354/8135	1.092e-10	6.843e-09	2.631e-09	FGF5/COL6A6/GNG13/GYS2/IFNA2/IFNB1/TNN/IL2/CHRM2/PCK1/IFNA1/IFNA13/GHR/FGF1/EFNA3/PPP2R5D/BCL2L11/BAD/PPP2R5C/ITGA11/AKT2/IGF1/PPP2CA/GNG5/GRB2/CASP9/MDM2/ATF4/RAC1/PIK3CB/ITGA5/GNB1/PPP2R2C/IL2RG/RPTOR/GNG2/SYK/CREB3/ITGB4/TSC1/FGF3/GNG10/SOS1/RPS6KB2/ITGA2/CCND1/MAP2K2/THBS4/EPOR/IKBKG/HSP90B1/PPP2R5B/PIK3R5/FGF18/LPAR2/PKN3/ANGPT2/PIK3CD/IFNAR1/RXRA/MAPK1/MLST8/PPP2R2D/MCL1/MTOR/TSC2/AKT1/AKT3/JAK3/PDGFRB/ATF6B/YWHAB/RPS6/IL6R/GNGT2/PTEN/EFNA4/PIK3AP1/NOS3/VWF/RAF1/LAMB1/CSF3R/KIT/MAPK3/GNB2/LAMA3/LPAR4/JAK2/RHEB/CCND3/PIK3R1/LAMA1/STK11/CDKN1A/ITGA2B/IL2RA/EIF4E2/CSF1R/VTN/LAMA2/FGF23/CREB5/PPP2R2A/THBS1/G6PC/ITGB7/VEGFC/EIF4EBP1/MAGI1/TNXB/GNB5/HRAS/CDC37/PIK3R2/BCL2L1/IKBKB/NTF3/PPP2R3C/YWHAQ/PIK3CA/IL4R/YWHAZ/PCK2/THBS3/F2R/ITGA8/FLT4/COL6A1/MTCP1/ITGB5/YWHAG/PRKAA1/CDKN1B/IRS1/GNB3/GNG3/BRCA1/PTK2/PKN1/RELA/GYS1/RBL2/MAP2K1/FGF10/LPAR6/FGFR4/LPAR5/HGF/NTRK1/PHLPP1/VEGFA/ITGA9/ITGAV/YWHAE/PKN2/IFNA8/LPAR1/HSP90AA1/GNG7/NFKB1/IGF1R/VEGFB/GNG11/SOS2/FLT1/PPP2R1A/FGF6/PPP2R2B/CRTC2/COL9A3/TLR2/OSM/PPP2R5A/ATF2/PPP2R3B/CCND2/ITGA7/NR4A1/G6PC2/IL3/ITGA10/CDK2/KRAS/PDGFD/CSF3/FGF7/FGFR2/COL9A1/CREB3L4/IL4/FGF4/CREB3L2/GNG8/ITGA4/FGF16/EGF/ITGB3/G6PC3/COL4A3/EIF4B/CREB1/SGK3/GNB4/GNGT1/COL4A5/GNG12/PDGFB/IFNAR2/IL3RA/CCNE2/EIF4E/COL9A2/THEM4/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PGF/PDGFC/IFNA16/ITGB1/INSR/HSP90AB1/FLT3LG/COMP/CCNE1/PHLPP2/FGF17/PRLR/PIK3CG/INS/TGFA/LAMC1/COL4A2/THBS2/CDK4/PIK3R6/SGK2/CD19/KDR/RPS6KB1/TP53/PPP2CB/COL1A1/COL4A6/CHRM1/FGF22/EFNA5/CHAD/IL7R/EPO/FGF2/ANGPT4/ERBB3/PDGFA/BDNF/LAMA5/ERBB4/FGF19/COL6A3/EFNA2/IL2RB/FGFR1/FLT3/NTRK2/PRKCA/NRAS/LAMB2/ITGB8/FOXO3/BCL2/CHUK/NTF4/LAMC3/CDK6/JAK1/FASLG/FGF20/PIK3R3/FN1/PPP2R1B/LAMC2/PDPK1/PPP2R5E/IGF2/EFNA1/GH1/GH2/DDIT4/LAMB4/TLR4/COL4A1/LAMA4/IFNA17/FGF9/CSF1/MET/GNG4/OSMR/PPP2R3A/ITGA3/PRKAA2/MYB/IL7/IL6/PDGFRA/ANGPT1/CREB3L1/COL6A2/SGK1/YWHAH/CSH1/KITLG/MYC/TEK/SPP1/GSK3B/TCL1B/NGF	323
KEGG	hsa05152	Tuberculosis	172/6408	180/8135	1.229e-10	6.843e-09	2.631e-09	IL12A/IFNA2/IFNB1/CLEC4M/IFNA1/IFNA13/ATP6V1H/PIK3C3/BAD/ITGB2/AKT2/CD209/CAMK2G/CASP9/IFNGR2/MAPK14/ATP6V0D1/RHOA/IL10RA/CEBPB/SYK/PPP3R2/ATP6V0A1/PLK3/CARD9/MYD88/CALML6/ATP6AP1/MRC2/LAMP2/ATP6V0B/ITGAM/TGFB1/TLR1/FCGR2A/TGFB2/IRAK1/LSP1/TNFRSF1A/MAPK1/TLR9/NFYC/CORO1A/RAB5A/AKT1/EP300/TRADD/AKT3/FADD/PPP3CB/RFXAP/MAPK9/RAF1/MAPK3/CASP3/IL10/TCIRG1/JAK2/VDR/CASP8/CALM2/IL1B/CD14/IRAK4/TRAF6/MAPK11/NOD2/IFNGR1/TIRAP/LAMP1/BAX/MAPK13/BID/CTSS/IL23A/FCER1G/TNF/MAPK12/CLEC7A/CALM1/CR1/CLEC4E/IL10RB/MALT1/STAT1/HSPD1/ITGAX/RAB5B/HLA-DMB/RELA/CTSD/FCGR3B/CAMK2B/FCGR2C/RAB7A/C3/ATP6V0A2/IFNA8/RIPK2/NFKB1/ATP6V0C/CYP27B1/PPP3CA/CAMP/FCGR1A/KSR1/APAF1/CALML4/ATP6V0D2/TLR2/RFXANK/CALML5/CYCS/RFX5/HLA-DMA/MAPK8/RAB5C/CD74/FCGR2B/CREB1/IL12B/BCL10/TLR6/CALM3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/HLA-DRA/IFNA16/SRC/CALML3/CAMK2D/CASP10/HLA-DPA1/PPP3CC/SPHK2/CAMK2A/CR1L/IL18/HSPA9/HLA-DOA/CIITA/PLA2R1/HLA-DQB1/IRAK2/CEBPG/FCGR3A/BCL2/JAK1/SPHK1/CREBBP/IFNG/PPP3R1/MAPK10/TLR4/EEA1/NFYB/HLA-DOB/IFNA17/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/ATP6V0A4/IL6/IL1A	172
KEGG	hsa05163	Human cytomegalovirus infection	211/6408	225/8135	2.838e-10	1.354e-08	5.207e-09	GNG13/IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/PTK2B/AKT2/TAPBP/GNG5/GRB2/CASP9/E2F1/MDM2/PLCB2/ATF4/PRKACA/RAC1/GNA13/MAPK14/PIK3CB/GNB1/RHOA/GNAQ/IL10RA/GNG2/PPP3R2/PXN/ARHGEF1/CREB3/HLA-B/RAC2/HLA-C/PRKCB/TSC1/GNG10/SOS1/CALML6/TAP1/RIPK1/RPS6KB2/CCND1/MAP2K2/PTGER4/IKBKG/GNA11/GNAI1/GNAI3/TBK1/NFATC1/PIK3CD/TNFRSF1A/MAPK1/MTOR/TSC2/AKT1/GNAS/TRADD/AKT3/ELK1/ATF6B/IL6R/GNGT2/FADD/ADCY8/PPP3CB/CRKL/HLA-A/ITPR3/PLCB4/RAF1/FAS/MAPK3/GNB2/ROCK1/CASP3/RHEB/CCR1/BCAR1/PIK3R1/CASP8/CDKN1A/CALM2/ARHGEF11/ADCY6/IL1B/MAPK11/CREB5/TRAF2/BAK1/IRF3/NFKBIA/EIF4EBP1/BAX/MAPK13/BID/GNB5/HRAS/PIK3R2/PTGER2/IKBKB/PIK3CA/TNF/ITPR2/MAPK12/ADCY4/CALM1/HLA-G/GNAI2/PLCB3/HLA-F/IL10RB/ROCK2/GNB3/CXCR4/ADCY7/GNG3/MAP2K6/PTK2/RELA/MAP2K1/TAP2/VEGFA/ITGAV/GNAO1/IFNA8/CDKN2A/CXCR2/GNG7/NFKB1/GNG11/SOS2/PPP3CA/E2F3/CRK/CALML4/ATF2/NFATC2/CALML5/CYCS/ITPR1/KRAS/PTGS2/CREB3L4/CREB3L2/GNG8/PRKACB/ITGB3/GNA12/CREB1/ADCY9/B2M/GNB4/GNGT1/AKAP13/GNG12/ADCY3/CALM3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PRKACG/IFNA16/CALR/SRC/CALML3/CCL4/PRKCG/CCL5/STAT3/CDK4/RPS6KB1/TP53/RB1/PPP3CC/PDIA3/CTNNB1/TRAF5/NFATC4/PLCB1/PRKCA/NRAS/CHUK/CDK6/JAK1/FASLG/PIK3R3/E2F2/NFATC3/PPP3R1/CCL2/IL1R1/ADCY1/PTGER1/IFNA17/PTGER3/GNG4/CCL3/CCL3L1/CCL3L3/IL6/PDGFRA/ADCY2/CREB3L1/CXCL12/MYC/GSK3B	211
KEGG	hsa04728	Dopaminergic synapse	128/6408	132/8135	1.211e-09	5.054e-08	1.943e-08	GNG13/GRIA2/DRD5/PPP2R5D/PPP2R5C/AKT2/PPP2CA/GNG5/CAMK2G/CLOCK/PLCB2/ATF4/PRKACA/MAPK14/GNB1/GNAQ/PPP2R2C/GNG2/CREB3/PRKCB/ARRB1/GNG10/CALML6/KCNJ6/PPP2R5B/CACNA1C/GNAI1/GNAI3/GSK3A/PPP2R2D/GRIN2B/ARRB2/AKT1/GNAS/AKT3/ATF6B/GNGT2/PPP3CB/MAPK9/ITPR3/PLCB4/GNB2/CALM2/MAPK11/CREB5/PPP2R2A/MAPK13/GNB5/KIF5C/PPP2R3C/ITPR2/MAPK12/CALM1/GNAI2/PLCB3/KIF5B/GRIA3/GNB3/LRTOMT/DRD1/GNG3/KCNJ5/CAMK2B/PPP1CA/ARNTL/GNAO1/GNG7/GNG11/PPP3CA/PPP2R1A/COMT/CALML4/PPP2R2B/MAOA/PPP2R5A/ATF2/PPP2R3B/CALY/CALML5/ITPR1/CREB3L4/CREB3L2/FOS/GNG8/PRKACB/MAPK8/CREB1/GNB4/GNGT1/GNG12/CALM3/PRKACG/CALML3/CAMK2D/PRKCG/PPP1CC/DRD2/PPP3CC/CACNA1D/PPP2CB/CAMK2A/GRIA4/KCNJ3/CACNA1B/SLC18A2/DRD3/PPP1CB/TH/PLCB1/PRKCA/DRD4/SCN1A/PPP2R1B/GRIN2A/PPP2R5E/MAPK10/SLC18A1/MAOB/GRIA1/GNG4/SLC6A3/PPP2R3A/KIF5A/CREB3L1/PPP1R1B/DDC/GSK3B/GNAL	128
KEGG	hsa04621	NOD-like receptor signaling pathway	174/6408	184/8135	1.514e-09	5.618e-08	2.16e-08	IFNA2/IFNB1/IFNA1/IFNA13/PLCB2/MAPK14/RHOA/NFKBIB/ANTXR2/BRCC3/CARD8/CARD9/MYD88/CARD16/GABARAP/NLRC4/NLRP1/RIPK1/IKBKG/MAP1LC3B/RIPK3/TYK2/ATG5/VDAC2/CASR/TBK1/GSDMD/ANTXR1/IFNAR1/MAPK1/CASP4/TNFAIP3/TXN/ATG12/FADD/PSTPIP1/TXNIP/GBP2/MAPK9/ITPR3/PLCB4/RBCK1/TICAM1/MAPK3/TRPM2/NOD1/CARD6/NLRP12/CASP8/VDAC3/MAP1LC3A/MFN2/IL1B/TRIP6/IRAK4/TRAF6/MAPK11/PYCARD/NOD2/TRAF2/MAVS/NLRX1/IRF3/NFKBIA/BIRC2/MAPK13/BCL2L1/IKBKB/RNASEL/CTSB/TAB2/IRF9/TNF/SUGT1/ITPR2/MAPK12/RNF31/GABARAPL1/CASP1/GABARAPL2/TRPV2/CXCL1/XIAP/IRF7/PLCB3/NAIP/IFI16/JUN/PANX1/NAMPT/STAT1/MAP3K7/STAT2/AIM2/PKN1/TP53BP1/RELA/CYBA/TAB1/MAP1LC3C/TAB3/YWHAE/GBP5/PKN2/IFNA8/RIPK2/NLRP3/TXN2/HSP90AA1/NFKB1/PRKCD/CYBB/TRPM7/TRAF3/IKBKE/CAMP/CASP5/GPRC6A/P2RX7/CXCL3/NLRP6/GBP4/ITPR1/MAPK8/IFNAR2/CASP12/DEFB103A/DEFB103B/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/HSP90AB1/GBP3/DNM1L/CCL5/PYDC1/NEK7/OAS1/SHARPIN/IL18/MAP1LC3B2/BIRC3/MEFV/DEFA5/MFN1/NLRP7/TRAF5/OAS3/PLCB1/DEFB4A/BCL2/CHUK/JAK1/TANK/MAPK10/CCL2/DEFA4/TLR4/IFNA17/DEFA1/DEFA1B/DEFA3/OAS2/GBP1/CARD18/VDAC1/IL6/DEFA6/DHX33	174
KEGG	hsa04722	Neurotrophin signaling pathway	116/6408	119/8135	2.285e-09	7.632e-08	2.935e-08	BAD/AKT2/GRB2/CAMK2G/ATF4/RAC1/MAPK14/PIK3CB/MAP3K3/SHC1/RHOA/ARHGDIG/NFKBIB/MAP2K5/SH2B1/KIDINS220/SOS1/CALML6/ARHGDIB/MAP2K2/NFKBIE/SORT1/PIK3CD/IRAK1/RPS6KA1/MAPK1/SHC3/AKT1/AKT3/PSEN1/ARHGDIA/RPS6KA3/CRKL/MAPK9/BRAF/ZNF274/RAF1/MAPK3/SH2B2/MATK/PLCG2/PIK3R1/CALM2/IRAK4/TRAF6/MAPK11/NFKBIA/BAX/MAPK13/HRAS/PIK3R2/IKBKB/NTF3/PIK3CA/MAP3K5/RAP1A/MAPK12/MAGED1/NTRK3/CALM1/MAPK7/MAPKAPK2/PRDM4/CDC42/JUN/IRS1/RELA/MAP2K1/CAMK2B/PSEN2/NTRK1/RPS6KA2/YWHAE/RIPK2/NFKB1/PRKCD/SOS2/ABL1/RAP1B/CRK/MAP2K7/CALML4/SH2B3/CALML5/KRAS/FRS2/PLCG1/MAPK8/RAPGEF1/IRAK3/CALM3/CALML3/CAMK2D/PTPN11/RPS6KA5/TP53/CAMK2A/MAP3K1/BDNF/IRAK2/SHC2/NTRK2/NRAS/FOXO3/BCL2/NTF4/FASLG/SHC4/PIK3R3/RPS6KA6/GAB1/PDPK1/MAPK10/CAMK4/GSK3B/NGF	116
KEGG	hsa04910	Insulin signaling pathway	132/6408	137/8135	3.138e-09	9.529e-08	3.664e-08	GYS2/PPP1R3A/PCK1/BAD/AKT2/PTPN1/INPPL1/GRB2/PRKACA/PIK3CB/SHC1/RPTOR/FBP1/TSC1/FLOT2/PPP1R3D/SOS1/CALML6/RPS6KB2/PHKA2/FLOT1/MAP2K2/ARAF/PIK3CD/HK3/EXOC7/MAPK1/SHC3/MTOR/TSC2/AKT1/PRKAB1/AKT3/ELK1/RPS6/CRKL/PHKG2/MAPK9/PPP1R3B/BRAF/RAF1/MAPK3/SH2B2/INPP5A/IRS2/RHEB/PYGL/PIK3R1/CALM2/EIF4E2/PPP1R3F/G6PC/PHKB/EIF4EBP1/HRAS/PIK3R2/IKBKB/PRKAG1/PIK3CA/HK1/PCK2/PRKAG2/CALM1/PYGM/MKNK1/PRKAA1/IRS1/HKDC1/GCK/PRKCZ/GYS1/MAP2K1/PPP1CA/CBLB/PYGB/RHOQ/PPP1R3E/PRKAR2A/SOS2/MKNK2/CRK/SREBF1/CALML4/CALML5/FOXO1/G6PC2/KRAS/SORBS1/FASN/PRKACB/PKLR/IRS4/MAPK8/ACACA/PHKG1/G6PC3/SOCS3/RAPGEF1/PRKAR1A/EIF4E/PRKAR1B/CBL/SOCS1/SOCS4/CALM3/PRKACG/PPP1R3C/INSR/CALML3/HK2/INS/PPP1CC/RPS6KB1/PHKA1/SOCS2/PPP1CB/SHC2/NRAS/PDE3B/SHC4/ACACB/PIK3R3/PDPK1/MAPK10/PTPRF/PRKAG3/PRKAA2/PRKAR2B/SLC2A4/FBP2/PRKAB2/GSK3B	132
KEGG	hsa05161	Hepatitis B	154/6408	162/8135	4.23e-09	1.177e-07	4.527e-08	IFNA2/IFNB1/IFNA1/IFNA13/PTK2B/BAD/AKT2/GRB2/CASP9/E2F1/ATF4/MAPK14/PIK3CB/STAT5B/STAT6/CREB3/PRKCB/MYD88/SOS1/ATP6AP1/MAP2K2/STAT5A/IKBKG/TYK2/TGFB1/TGFB2/TBK1/NFATC1/ARAF/PIK3CD/IRAK1/IFNAR1/HSPG2/MAPK1/AKT1/EP300/AKT3/JAK3/ELK1/ATF6B/YWHAB/FADD/SMAD4/MAPK9/TICAM1/BRAF/RAF1/FAS/MAPK3/CASP3/JAK2/DDX3X/PIK3R1/CASP8/CDKN1A/VDAC3/DDB2/IRAK4/TRAF6/MAPK11/CREB5/MAVS/TIRAP/IRF3/NFKBIA/SMAD3/BAX/MAPK13/BID/HRAS/PIK3R2/IKBKB/YWHAQ/PIK3CA/TAB2/TNF/YWHAZ/MAPK12/DDB1/IRF7/JUN/MAP2K4/STAT1/MAP3K7/STAT2/MAP2K6/RELA/MAP2K1/TAB1/DDX58/IFNA8/NFKB1/SOS2/CCNA2/TRAF3/IKBKE/E2F3/APAF1/MAP2K7/IFIH1/TLR2/TGFBR2/MMP9/ATF2/NFATC2/CYCS/CDK2/KRAS/CREB3L4/CREB3L2/FOS/TICAM2/MAPK8/PCNA/CREB1/TGFBR1/CCNE2/CASP12/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/SRC/CCNE1/CASP10/PRKCG/SLC10A1/STAT4/STAT3/TP53/RB1/MAP3K1/NFATC4/MAP2K3/PRKCA/NRAS/BCL2/CHUK/JAK1/FASLG/PIK3R3/E2F2/CREBBP/NFATC3/MAPK10/TLR4/IFNA17/IL6/CREB3L1/MYC	154
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	182/6408	194/8135	4.597e-09	1.181e-07	4.541e-08	GNG13/IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/PIK3C3/AKT2/GNG5/CLEC2B/CASP9/E2F1/RAC1/MAPK14/PIK3CB/GNB1/GNG2/SYK/PPP3R2/HLA-B/HLA-C/UBC/GNG10/CALML6/CCND1/MAP2K2/IKBKG/MAP1LC3B/PIK3R5/TYK2/ANGPT2/TBK1/NFATC1/PIK3CD/IFNAR1/ZFP36/TNFRSF1A/MAPK1/MTOR/AKT1/EP300/TRADD/AKT3/GNGT2/FADD/PPP3CB/HLA-A/MAPK9/ITPR3/TICAM1/RAF1/FAS/MAPK3/GNB2/CASP3/JAK2/PLCG2/CCR1/PIK3R1/CASP8/CDKN1A/MAP1LC3A/CALM2/MAPK11/IFNGR1/TRAF2/BAK1/IRF3/NFKBIA/BAX/MAPK13/BID/GNB5/HRAS/PIK3R2/IKBKB/ATG3/PIK3CA/IRF9/RCAN1/UBA52/ITPR2/MAPK12/MICA/HCK/CXCL1/CALM1/IL6ST/BECN1/HLA-G/IRF7/MAPKAPK2/ICAM1/LYN/TCF7/JUN/HLA-F/MAP2K4/STAT1/PREX1/GNB3/GNG3/STAT2/MAP2K6/RELA/MAP2K1/C3/MAP1LC3C/VEGFA/CSF2/IFNA8/GNG7/NFKB1/GNG11/TRAF3/IKBKE/PPP3CA/E2F3/HIF1A/MAP2K7/CXCL3/CALML4/TCF7L2/NFATC2/CALML5/CYCS/CD86/ITPR1/EIF2AK2/KRAS/PTGS2/FOS/GNG8/PLCG1/MAPK8/CREB1/GNB4/MICB/GNGT1/GNG12/PDGFB/IFNAR2/CALM3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/SRC/CALML3/PIK3CG/STAT3/CDK4/PIK3R6/TP53/RB1/PPP3CC/MAP1LC3B2/FGF2/CTNNB1/NFATC4/NRAS/CHUK/CDK6/JAK1/PIK3R3/E2F2/CREBBP/NFATC3/PPP3R1/MAPK10/RPS27A/IFNA17/GNG4/CCR4/IL6/MYC/UBB/GSK3B	182
KEGG	hsa04010	MAPK signaling pathway	268/6408	294/8135	5.893e-09	1.406e-07	5.405e-08	FGF5/PTPRR/FGF1/EFNA3/PAK1/SRF/AKT2/IGF1/CACNB3/GRB2/ATF4/PRKACA/RAC1/GADD45B/MAPK14/MAP3K3/CACNB1/PPP3R2/MAP2K5/RAC2/PRKCB/PLA2G4D/FGF3/ARRB1/MYD88/SOS1/MAP2K2/IKBKG/FGF18/CACNA1C/TGFB1/ANGPT2/TGFB2/NFATC1/HSPA6/ARAF/IRAK1/RPS6KA1/TNFRSF1A/MAPK1/PPM1B/FLNC/ARRB2/AKT1/NF1/PLA2G4C/TRADD/DAXX/AKT3/DUSP2/PDGFRB/ELK1/RPS6KA3/MAP4K2/PPP3CB/CRKL/MAPK9/EFNA4/BRAF/RAF1/KIT/FAS/MAPK3/CASP3/RRAS/MAP3K12/MAP4K4/RELB/CACNG1/IL1B/CD14/IRAK4/CSF1R/TRAF6/MAPK11/FGF23/DUSP3/TRAF2/VEGFC/JUND/MAPK13/CACNA2D1/HRAS/IKBKB/NTF3/JMJD7-PLA2G4B/PLA2G4B/MAP3K5/CACNG8/TAB2/RAP1A/TNF/HSPA8/MAP3K11/MAP4K1/DDIT3/MAPK12/HSPA1L/CACNA2D4/HSPA1A/MAPK7/FLT4/MAPKAPK2/CDC42/CDC25B/RPS6KA4/STMN1/MKNK1/JUN/MAP2K4/NFKB2/PTPN7/CACNA1H/PAK2/STK4/MAP3K7/MAP2K6/RELA/RASA1/MAP2K1/FGF10/FGFR4/RASGRP2/TAOK3/MAPK8IP3/TAB1/HGF/NTRK1/VEGFA/RASGRP4/PLA2G4F/RPS6KA2/MAPKAPK3/CACNA2D2/NFKB1/IGF1R/VEGFB/SOS2/DUSP1/TAOK1/PPP3CA/FLT1/RAP1B/MKNK2/CRK/GADD45A/HSPB1/RASGRP1/MAP2K7/FGF6/MAP3K4/PPP5C/TGFBR2/GADD45G/DUSP9/ATF2/NR4A1/CACNA1F/MEF2C/MAP3K6/KRAS/PDGFD/FGF7/STK3/MAP3K2/FGFR2/FLNB/FGF4/FOS/PRKACB/HSPA1B/MAPK8/DUSP7/CACNA1I/FGF16/EGF/CACNA1S/CACNA1E/GNA12/TGFBR1/ECSIT/GNG12/PDGFB/FLNA/RASA2/MAPK8IP1/PRKACG/PGF/PDGFC/INSR/ELK4/FLT3LG/FGF17/MAP3K14/PRKCG/INS/CACNB2/TGFA/RPS6KA5/TAOK2/KDR/TP53/DUSP6/PPP3CC/CACNA1D/DUSP8/MAP3K1/MAPK8IP2/CACNG4/CACNA1B/FGF22/CACNG3/MAP3K8/EFNA5/FGF2/ANGPT4/ERBB3/RASGRF2/PDGFA/BDNF/ERBB4/FGF19/EFNA2/FGFR1/FLT3/MAP2K3/RASGRP3/NTRK2/PRKCA/NRAS/CHUK/NTF4/FASLG/FGF20/PLA2G4A/RPS6KA6/MAPT/NFATC3/IGF2/PPP3R1/EFNA1/MAPK10/IL1R1/CACNA1G/MRAS/FGF9/PTPN5/CSF1/MET/PPM1A/MAX/RAPGEF2/DUSP4/PDGFRA/DUSP16/ANGPT1/CACNG5/MECOM/KITLG/MYC/CACNG2/TEK/HSPA2/IL1A/RASGRF1/IL1RAP/RRAS2/NGF	268
KEGG	hsa04142	Lysosome	127/6408	132/8135	8.781e-09	1.955e-07	7.518e-08	ATP6V1H/PPT2/ENTPD4/GALNS/GALC/ATP6V0D1/GGA3/PSAP/ATP6V0A1/MANBA/AP3M1/CLTC/ABCA2/GNPTAB/HYAL4/ATP6AP1/CD63/LAMP2/ATP6V0B/GNPTG/GUSB/FUCA2/SORT1/IDUA/SGSH/TPP1/GLB1/SLC11A2/CTSF/CTSA/HGSNAT/ARSG/HYAL3/AP1M1/AGA/GBA/AP1G2/HEXB/PLA2G15/TCIRG1/CD68/MAN2B1/AP1B1/HYAL1/GGA1/IDS/AP4B1/AP3S1/GLA/NPC2/SMPD1/CLTCL1/LAMP1/CTSS/CTSB/SLC11A1/HEXA/HYAL2/NAGLU/SUMF1/GNS/LITAF/ARSA/GM2A/CD164/DNASE2B/CTSC/WDR7/GAA/PPT1/LAPTM4A/NEU1/LAPTM4B/CLTA/CLTB/AP3M2/AP1S1/CTSZ/CTSD/CTSH/CLN5/DMXL2/ATP6V0A2/SPAM1/NCOA7/ATP6V0C/AP1G1/CTNS/DMXL1/AP3S2/ATP6V0D2/MFSD8/LIPA/IGF2R/GGA2/AP3B1/M6PR/AP3D1/AP1M2/CTSW/ACP5/NAGPA/LGMN/NAPSA/CTSK/DNASE2/NPC1/CLN3/LAPTM5/ASAH1/LAMP3/NAGA/AP1S2/AP4M1/ACP2/ABCB9/MCOLN1/AP4S1/FUCA1/AP3B2/AP4E1/AP1S3/SCARB2/ATP6V0A4/SLC17A5/CTSG/CTSO	127
KEGG	hsa05171	Coronavirus disease - COVID-19	214/6408	232/8135	1.518e-08	3.17e-07	1.219e-07	IL12A/IFNA2/IFNB1/MAS1/MBL2/IL2/MMP3/F13B/IFNA1/IFNA13/C9/ADAR/RPL35A/MAPK14/PIK3CB/NFKBIB/RPL26/SYK/C1R/RPS24/PRKCB/RPL34/MYD88/IKBKG/TYK2/RPL32/FCGR2A/TBK1/MX2/RPL37A/RPL41/PIK3CD/IRAK1/RPL26L1/IFNAR1/TNFRSF1A/RPS13/MAPK1/RPL19/C6/RPL21/RPS23/RPL31/FGB/RPL38/RPS6/IL6R/RPL6/MAPK9/RPL30/VWF/RPL39/MAPK3/PLCG2/RPL17/PIK3R1/RPL24/C2/IL1B/RPL12/RPS15A/IRAK4/TRAF6/RPS7/MAPK11/RPSA/MAVS/IRF3/NFKBIA/MAPK13/RPL23A/RPL7/RPL28/PIK3R2/RPS27L/IKBKB/RPS12/PIK3CA/RPS21/TAB2/IRF9/TNF/RPL22L1/UBA52/RPL11/RPL7A/MAPK12/RPL37/RPS11/ADAM17/CASP1/RPS4X/IL6ST/RPLP0/C5AR1/RPS17/RPL10/SELP/RPL23/JUN/STAT1/TLR8/MAP3K7/RPS27/STAT2/RPS28/RPL27A/RPL36/RELA/C1QB/RPS2/RPLP1/RPL10A/RPL36AL/RPL18/AGTR1/C3/CFB/DDX58/CSF2/IFNA8/FAU/NLRP3/RPL13A/NFKB1/CYBB/TRAF3/IKBKE/RPS19/RPS29/IFIH1/RPL10L/RPS20/TLR2/C5/C1QA/RPL15/RPL14/RPL9/EIF2AK2/TLR7/CSF3/RPL27/C3AR1/TMPRSS2/FOS/RPS18/PLCG1/MAPK8/RPS15/CFD/RPL5/RPL36A/RPS25/RPS16/RPL3/IL12B/RPL13/RPS10/IFNAR2/ISG15/RPS14/F13A1/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/RPS5/MX1/IFNA16/RPLP2/RPS8/MASP2/PRKCG/RPL29/RPL22/STAT3/OAS1/RPL35/C1S/RPL8/ACE/OAS3/RPS3A/RPS9/C8A/RPS4Y1/MASP1/PRKCA/CHUK/JAK1/ACE2/MMP1/PIK3R3/C4A/C4B/C1QC/HBEGF/MAPK10/RPS27A/CCL2/TLR4/RPL4/RPS3/IFNA17/F2/RPS26/OAS2/FGA/IL6/RPL3L	214
KEGG	hsa05164	Influenza A	161/6408	171/8135	1.716e-08	3.371e-07	1.296e-07	IL12A/IFNA2/IFNB1/IL33/SLC25A31/IFNA1/IFNA13/ADAR/AKT2/ACTG1/CASP9/IFNGR2/PIK3CB/NFKBIB/RAE1/PRKCB/CALCOCO2/MYD88/MAP2K2/DNAJB1/IKBKG/SLC25A4/TYK2/TBK1/NXF1/MX2/PIK3CD/IFNAR1/NUP98/TNFRSF1A/DNAJC3/MAPK1/AKT1/EP300/TRADD/AKT3/FADD/FDPS/TICAM1/RAF1/FAS/MAPK3/CASP3/CPSF4/EIF2S1/JAK2/CCND3/PIK3R1/CASP8/RAB11A/NXT2/IL1B/IRAK4/XPO1/PYCARD/IFNGR1/MAVS/BAK1/NLRX1/IRF3/NFKBIA/BAX/ACTB/TNFRSF10B/BID/PIK3R2/IKBKB/RNASEL/PIK3CA/IRF9/TNF/CASP1/KPNA2/SLC25A5/KPNA6/PLG/HNRNPUL1/IRF7/ICAM1/PABPN1/TNFSF10/STAT1/HLA-DMB/STAT2/RELA/MAP2K1/PML/DDX58/IFNA8/NLRP3/NXF2/NXF2B/NFKB1/NXT1/TRAF3/IKBKE/APAF1/IFIH1/TPSB2/KPNA1/CYCS/EIF2AK2/TLR7/TMPRSS2/HLA-DMA/TNFRSF10A/IL12B/SOCS3/IFNAR2/RAB11B/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/TRIM25/MX1/HLA-DRA/IFNA16/KPNA5/CCL5/CDK4/HLA-DPA1/OAS1/IL18/HLA-DOA/CIITA/HLA-DQB1/OAS3/RSAD2/TPSD1/PRKCA/CHUK/CDK6/JAK1/FASLG/PRSS2/PRSS3/PIK3R3/CREBBP/IFNG/CCL2/TMPRSS4/TLR4/HLA-DOB/SLC25A6/IFNA17/HLA-DQA1/HLA-DQA2/TMPRSS11D/HLA-DRB3/HLA-DRB5/OAS2/VDAC1/HLA-DRB1/HLA-DRB4/IL6/IL1A/PRSS1	161
KEGG	hsa04210	Apoptosis	130/6408	136/8135	2.387e-08	4.381e-07	1.684e-07	PARP3/BCL2L11/BAD/AKT2/ACTG1/TUBA1A/CASP9/TUBA1C/BCL2A1/ATF4/GADD45B/PIK3CB/HTRA2/CFLAR/RIPK1/MAP2K2/IKBKG/PIK3CD/TNFRSF1A/MAPK1/TUBAL3/CTSF/MCL1/AKT1/TRADD/DAXX/AKT3/FADD/TUBA3D/TUBA3E/TUBA4A/MAPK9/ITPR3/TUBA3C/RAF1/FAS/MAPK3/CASP3/EIF2S1/PARP4/PIK3R1/CASP8/PARP1/TUBA1B/CSF2RB/TRAF2/ENDOG/BAK1/NFKBIA/BAX/BIRC2/ACTB/TNFRSF10B/BBC3/BID/CAPN2/HRAS/PIK3R2/BCL2L1/IKBKB/CTSS/CTSB/LMNB2/PIK3CA/MAP3K5/TNF/DDIT3/ITPR2/CASP2/XIAP/LMNA/CTSC/DIABLO/TNFSF10/JUN/EIF2AK3/RELA/CTSZ/CTSD/MAP2K1/CTSH/NTRK1/ATM/NFKB1/GADD45A/SPTAN1/APAF1/AIFM1/GADD45G/TUBA8/CYCS/ITPR1/IL3/KRAS/LMNB1/DFFA/TRAF1/DAB2IP/CTSW/FOS/TNFRSF10A/MAPK8/PTPN13/CTSK/IL3RA/CASP12/ERN1/CASP10/MAP3K14/PARP2/CASP7/TP53/PMAIP1/PRF1/GZMB/CAPN1/BIRC3/TP53AIP1/CASP6/NRAS/BCL2/CHUK/FASLG/PIK3R3/PDPK1/DFFB/MAPK10/SPTA1/CTSO/NGF	130
KEGG	hsa00562	Inositol phosphate metabolism	73/6408	73/8135	2.492e-08	4.381e-07	1.684e-07	PLCH1/PIK3C3/PLCD1/INPPL1/PLCB2/PIK3CB/TPI1/ITPKC/MTMR14/IPPK/ITPKB/ITPK1/MTMR3/INPP5D/PIK3C2G/PLCH2/PIK3CD/PIP5K1C/INPP5E/PTEN/SACM1L/PLCB4/PI4KA/INPP5A/FIG4/PI4K2A/IMPA2/PLCG2/INPP5K/CDIPT/MTMR6/PI4KB/PIK3CA/PLCB3/MTMR1/ISYNA1/MTMR4/INPP5B/PIP4K2A/PI4K2B/MTM1/IMPA1/PLCD3/PIP5K1A/INPP4B/PLCZ1/INPP4A/PIP5KL1/PLCG1/IPMK/ITPKA/SYNJ1/PIP5K1B/INPP1/PLCD4/PIP4K2B/MTMR2/PIK3CG/PIP4K2C/MIOX/PIKFYVE/PIK3C2A/MINPP1/SYNJ2/PLCB1/PLCE1/INPP5F/OCRL/MTMR7/MTMR8/PIK3C2B/INPP5J/ALDH6A1	73
KEGG	hsa05170	Human immunodeficiency virus 1 infection	196/6408	212/8135	3.8e-08	6.346e-07	2.44e-07	GNG13/IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/CCNB3/PAK1/PTK2B/BAD/AKT2/TAPBP/GNG5/CASP9/CFL1/RAC1/MAPK14/PIK3CB/GNB1/GNAQ/GNG2/PPP3R2/PXN/HLA-B/TNFRSF1B/RAC2/HLA-C/PRKCB/MYD88/GNG10/CALML6/TAP1/RIPK1/RPS6KB2/MAP2K2/IKBKG/GNA11/GNAI1/GNAI3/TBK1/NFATC1/PIK3CD/SAMHD1/IRAK1/TNFRSF1A/MAPK1/LIMK1/MTOR/AKT1/TRADD/AKT3/AP1M1/CD4/AP1G2/GNGT2/FADD/PPP3CB/CRKL/HLA-A/LIMK2/MAPK9/ITPR3/RAF1/FAS/MAPK3/GNB2/CASP3/RNF7/AP1B1/PLCG2/PIK3R1/CASP8/CALM2/IRAK4/TRAF6/MAPK11/APOBEC3F/CDK1/TRAF2/BAK1/IRF3/NFKBIA/BAX/MAPK13/BID/GNB5/HRAS/PIK3R2/BCL2L1/IKBKB/PIK3CA/TAB2/TNF/ITPR2/MAPK12/CUL4B/DDB1/ATR/CALM1/HLA-G/APOBEC3C/GNAI2/JUN/HLA-F/BTRC/PAK2/GNB3/CXCR4/MAP3K7/GNG3/MAP2K6/PTK2/AP1S1/RELA/CD3D/MAP2K1/CUL1/TAB1/TAP2/APOBEC3G/GNAO1/IFNA8/ATM/GNG7/NFKB1/GNG11/PPP3CA/AP1G1/CRK/MAP2K7/CALML4/TLR2/CUL4A/SKP1/NFATC2/CALML5/PAK4/CYCS/AP1M2/ITPR1/FBXW11/KRAS/RBX1/FOS/GNG8/PLCG1/MAPK8/TRIM5/B2M/GNB4/GNGT1/GNG12/CD3G/CALM3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/CALR/CALML3/CFL2/PRKCG/RPS6KB1/PPP3CC/CUL5/AP1S2/APOBEC3A/PDIA3/APOBEC3D/TRAF5/NFATC4/MAP2K3/PRKCA/NRAS/BCL2/CHUK/FASLG/PIK3R3/PAK3/CDC25C/NFATC3/PPP3R1/MAPK10/BST2/TLR4/CD3E/IFNA17/CCNB2/AP1S3/GNG4/PAK6/WEE1	196
KEGG	hsa04014	Ras signaling pathway	213/6408	232/8135	4.841e-08	7.699e-07	2.96e-07	FGF5/GNG13/RASSF5/PLA2G2D/FGF1/EFNA3/PAK1/BAD/AKT2/IGF1/GNG5/GRB2/PRKACA/RAC1/PIK3CB/SHC1/GNB1/RHOA/GNG2/RAC2/PRKCB/PLA2G4D/FGF3/GNG10/SOS1/CALML6/MAP2K2/IKBKG/FGF18/RAPGEF5/SYNGAP1/BRAP/ANGPT2/TBK1/PIK3CD/MAPK1/GRIN2B/SHC3/RAB5A/AKT1/NF1/PLA2G4C/PLD2/AKT3/PDGFRB/ELK1/RASAL3/GNGT2/MAPK9/RIN1/EFNA4/RAF1/KIT/MAPK3/GNB2/RRAS/PLCG2/PIK3R1/CALM2/RASA4B/CSF1R/FGF23/PLA2G6/PLD1/VEGFC/RALA/GNB5/HRAS/PIK3R2/BCL2L1/IKBKB/NTF3/JMJD7-PLA2G4B/PLA2G4B/RGL2/PIK3CA/RAP1A/ETS2/RALGDS/ABL2/CALM1/FLT4/ARF6/CDC42/GAB2/PLA2G12A/RALBP1/PAK2/GNB3/STK4/RAB5B/GNG3/RELA/LAT/RASA1/MAP2K1/FGF10/FGFR4/RASGRP2/HGF/NTRK1/VEGFA/RASGRP4/PLA2G4F/GNG7/NFKB1/IGF1R/VEGFB/GNG11/SOS2/ABL1/FLT1/KSR1/RAP1B/RALB/HTR7/RASGRP1/FGF6/CALML4/FOXO4/PLA2G2A/RASSF1/ZAP70/CALML5/PAK4/KRAS/PDGFD/FGF7/GRIN1/FGFR2/FGF4/GNG8/PRKACB/PLCG1/MAPK8/RAB5C/FGF16/EGF/RGL1/GNB4/GNGT1/RASA4/RASAL2/GNG12/RASA3/PDGFB/RASA2/CALM3/PRKACG/PGF/PDGFC/INSR/TIAM1/CALML3/FLT3LG/FGF17/PTPN11/PRKCG/INS/TGFA/KDR/EXOC2/FGF22/EFNA5/ETS1/SHOC2/FGF2/ANGPT4/RASGRF2/PDGFA/BDNF/FGF19/EFNA2/FGFR1/FLT3/SHC2/RASGRP3/NTRK2/PRKCA/NRAS/PLA1A/CHUK/NTF4/FASLG/SHC4/FGF20/PIK3R3/PLA2G4A/GAB1/PLCE1/PAK3/GRIN2A/IGF2/EFNA1/MAPK10/MRAS/PLA2G2F/FGF9/CSF1/MET/GNG4/RASAL1/PDGFRA/ANGPT1/KITLG/PAK6/TEK/RASGRF1/REL/PLA2G1B/RRAS2/PLA2G12B/NGF	213
KEGG	hsa04218	Cellular senescence	147/6408	156/8135	6.265e-08	9.511e-07	3.657e-07	SLC25A31/LIN54/RASSF5/HLA-E/CCNB3/HIPK4/RAD9A/AKT2/E2F1/MDM2/GADD45B/MAPK14/PIK3CB/PPP3R2/HLA-B/HLA-C/TSC1/CALML6/CCND1/MAP2K2/LIN52/SLC25A4/TGFB1/VDAC2/TGFB2/NFATC1/PIK3CD/SMAD2/MAPK1/MTOR/TSC2/AKT1/AKT3/PPP3CB/PTEN/SQSTM1/HLA-A/ITPR3/RAF1/MAPK3/RRAS/RHEB/CCND3/PIK3R1/CDKN1A/VDAC3/CALM2/RAD50/MAPK11/CDK1/LIN37/HUS1/MYBL2/SMAD3/EIF4EBP1/MAPK13/CAPN2/HRAS/PIK3R2/PIK3CA/TRAF3IP2/ITPR2/MAPK12/SLC25A5/ATR/CALM1/HLA-G/MAPKAPK2/PPID/NBN/HLA-F/BTRC/MAP2K6/RELA/RBL2/MAP2K1/PPP1CA/ZFP36L2/CDKN2A/ATM/NFKB1/CCNA2/TRPM7/PPP3CA/E2F3/FOXM1/GADD45A/E2F4/CHEK2/KIR2DL4/CALML4/CDKN2B/HIPK1/TGFBR2/GADD45G/CCND2/NFATC2/CALML5/FOXO1/ITPR1/FBXW11/CDK2/KRAS/HIPK3/SIRT1/SERPINE1/TGFBR1/RBBP4/RAD9B/CCNE2/ZFP36L1/CALM3/CALML3/CCNE1/PPP1CC/CDK4/TP53/RB1/PPP3CC/CACNA1D/CAPN1/ETS1/PPP1CB/NFATC4/MAP2K3/NRAS/FOXO3/RAD1/CDK6/PIK3R3/E2F2/RBL1/NFATC3/PPP3R1/HIPK2/MRAS/SLC25A6/CCNB2/IGFBP3/E2F5/VDAC1/IL6/TRPV4/MYC/IL1A/LIN9/RRAS2	147
KEGG	hsa04141	Protein processing in endoplasmic reticulum	160/6408	171/8135	7.112e-08	1.033e-06	3.971e-07	ATXN3L/UBQLN3/SYVN1/NPLOC4/SSR2/UBE4B/ATF4/P4HB/UBXN1/DERL2/UBXN4/NGLY1/SEC61B/DNAJC5G/OS9/PDIA6/RNF185/UBE2G1/HSPA5/PRKCSH/UBE2J2/DNAJB1/UBQLN1/HSP90B1/PREB/TUSC3/TRAM1L1/PPP1R15A/HERPUD1/HSPA6/LMAN1L/BCAP31/DNAJC3/FBXO2/STUB1/SEC24C/LMAN2/UBQLN2/SEC13/ATF6B/SEC24B/DAD1/MAPK9/SIL1/CKAP4/EIF2S1/DNAJC5/UBE2J1/VCP/XBP1/PDIA4/PLAA/HSPA4L/TRAF2/DNAJC1/BAK1/DNAJB12/UBE2D2/DNAJB11/STT3B/BAX/SEC61A2/CAPN2/AMFR/RAD23B/DNAJA1/UBE2D1/DNAJC10/MAP3K5/MBTPS1/SSR4/MAN1B1/HSPA8/DDIT3/UGGT2/HSPA1L/ATF6/RPN2/EIF2AK1/MOGS/UGGT1/HSPA1A/HYOU1/SAR1B/HSPBP1/EIF2AK3/UBXN2A/ERLEC1/RNF5/CUL1/SEC61G/DERL1/SEL1L/DDOST/HSP90AA1/NFE2L2/SEC24D/SSR1/CANX/SEC31B/EDEM1/RRBP1/ATXN3/MAP2K7/HSPH1/SAR1A/GANAB/SKP1/NSFL1C/EIF2AK2/DNAJB2/RBX1/SEC23B/YOD1/HSPA1B/MAPK8/SEC61A1/SVIP/FBXO6/EDEM3/SSR3/UBQLN4/TRAM1/CASP12/EDEM2/ERN1/SEC23A/UBE2D3/CALR/HSP90AB1/SEC62/UBE2D4/DERL3/ERP29/WFS1/PDIA3/UBXN6/SEL1L2/CAPN1/MAN1C1/UBE2G2/MAN1A1/BAG2/BCL2/SEC24A/MAPK10/SEC31A/CRYAB/STT3A/RAD23A/DNAJC5B/TXNDC5/LMAN1/SEC63/CRYAA/EIF2AK4/BAG1/MAN1A2/UBXN8/HSPA2	160
KEGG	hsa04932	Non-alcoholic fatty liver disease	146/6408	155/8135	7.537e-08	1.036e-06	3.985e-07	ADIPOQ/COX6A2/COX8C/COX7B2/COX4I2/ADIPOR2/NDUFS7/UQCRB/BCL2L11/UQCRQ/COX5B/NDUFS1/NDUFC1/AKT2/NDUFB3/NDUFA1/PPARA/NDUFS2/ATF4/RAC1/MAPK14/PIK3CB/COX6B1/COX8A/NDUFB10/MLX/NDUFA4/NDUFV2/UQCRFS1/TGFB1/NDUFB4/NDUFA10/PIK3CD/NDUFB2/UQCR10/MLXIP/TNFRSF1A/RXRA/NDUFB11/GSK3A/AKT1/UQCRH/PRKAB1/AKT3/COX7B/SDHA/COX7A2/NDUFB6/NDUFB8/IL6R/UQCRC2/MAPK9/FAS/NDUFA7/CASP3/EIF2S1/IRS2/NDUFA2/COX6C/NDUFC2/PIK3R1/CASP8/XBP1/NDUFA6/IL1B/MAPK11/TRAF2/NDUFS8/NDUFB1/BAX/MAPK13/NDUFA12/NDUFS3/BID/PIK3R2/IKBKB/COX4I1/CYC1/PRKAG1/PIK3CA/MAP3K5/TNF/MAP3K11/DDIT3/UQCR11/MAPK12/NDUFA9/NDUFS4/PRKAG2/SDHB/COX6B2/CDC42/NDUFA11/NDUFV1/JUN/PRKAA1/NDUFB5/NDUFAB1/IRS1/EIF2AK3/SDHC/RELA/COX5A/NDUFS6/NDUFA3/NDUFB9/COX6A1/NFKB1/NDUFS5/SREBF1/COX7C/NR1H3/CYCS/NDUFA8/LEP/FOS/PKLR/MAPK8/NDUFA13/COX7A2L/NDUFA5/SOCS3/ERN1/INSR/CEBPA/INS/NDUFV3/CASP7/SDHD/ADIPOR1/ITCH/FASLG/PIK3R3/CYP2E1/MAPK10/UQCRC1/NDUFB7/LEPR/PRKAG3/PRKAA2/IL6/PPARG/PRKAB2/NDUFA4L2/GSK3B/IL1A	146
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	204/6408	222/8135	7.757e-08	1.036e-06	3.985e-07	SLC25A31/IL2/HLA-E/SRF/ITGB2/AKT2/TLN1/RANBP3/E2F1/ATF4/PRKACA/ANAPC1/PIK3CB/MAP3K3/CD40/IL2RG/STAT5B/PPP3R2/ANAPC7/CREB3/HLA-B/HLA-C/POLB/RAN/CRTC1/CCND1/MAP2K2/STAT5A/LTBR/IKBKG/SLC25A4/TGFB1/VDAC2/TGFB2/ANAPC2/NFATC1/PIK3CD/ANAPC10/ZFP36/SMAD2/TNFRSF1A/MAPK1/AKT1/EP300/AKT3/JAK3/ELK1/ATF6B/CD4/ITGAL/ADCY8/FDPS/PPP3CB/SPI1/PTEN/HLA-A/SMAD4/MAPK9/MAPK3/CDC27/RELB/PTTG2/CDC26/CCND3/PIK3R1/CDKN1A/VDAC3/IL2RA/ADCY6/ANAPC5/KAT5/XPO1/CREB5/TBPL1/NFKBIA/SMAD3/BAX/HRAS/PIK3R2/BCL2L1/IKBKB/PIK3CA/CRTC3/TNF/ETS2/ANAPC4/ADCY4/SLC25A5/ATR/XIAP/HLA-G/ICAM1/VAC14/TLN2/ANAPC13/JUN/HLA-F/MAP2K4/NFKB2/PTTG1/TERT/GPS2/ADCY7/CDKN2C/HLA-DMB/RELA/CD3D/MAP2K1/ANAPC11/CSF2/CDKN2A/ATM/DLG1/NFKB1/IL1R2/CCNA2/PPP3CA/E2F3/CANX/CDC16/CHEK2/CDKN2B/CRTC2/TGFBR2/KAT2B/LCK/MAD1L1/ATF2/CCND2/NFATC2/TSPO/CDK2/KRAS/CREB3L4/CREB3L2/FOS/PRKACB/SLC2A1/HLA-DMA/MAPK8/LTA/CREB1/ADCY9/B2M/TGFBR1/ADCY3/CCNE2/CD3G/PRKACG/HLA-DRA/CALR/ELK4/CCNE1/MAP3K14/KAT2A/CDK4/HLA-DPA1/TP53/RB1/PPP3CC/BUB1B/MAP3K1/ANAPC16/ETS1/HLA-DOA/HLA-DQB1/NFATC4/IL2RB/TRRAP/NRAS/CHUK/JAK1/PIK3R3/E2F2/IL15/TCF3/CDC23/CREBBP/NFATC3/PPP3R1/MAPK10/IL1R1/NFYB/IL15RA/CD3E/HLA-DOB/MSX2/BUB3/ADCY1/SLC25A6/TBP/CCNB2/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/VDAC1/HLA-DRB1/HLA-DRB4/IL6/ADCY2/CREB3L1/MYC/TNFRSF13C	204
KEGG	hsa04659	Th17 cell differentiation	104/6408	108/8135	1.839e-07	2.347e-06	9.024e-07	IL2/IFNGR2/MAPK14/IL2RG/NFKBIB/STAT5B/PPP3R2/STAT6/STAT5A/IKBKG/TYK2/TGFB1/NFKBIE/NFATC1/RUNX1/IL27RA/EBI3/SMAD2/RXRA/MAPK1/MTOR/JAK3/CD4/IL6R/PPP3CB/SMAD4/MAPK9/IL17A/MAPK3/IL22/JAK2/IL12RB1/IL2RA/IL1B/MAPK11/IFNGR1/NFKBIA/SMAD3/MAPK13/IKBKB/IL23A/IL4R/MAPK12/IL6ST/JUN/RARA/STAT1/RXRB/HLA-DMB/RELA/CD3D/LAT/HSP90AA1/NFKB1/PPP3CA/HIF1A/FOXP3/PRKCQ/TGFBR2/LCK/IL21R/RORC/NFATC2/ZAP70/IL4/FOS/HLA-DMA/PLCG1/MAPK8/IL21/GATA3/TGFBR1/CD3G/HLA-DRA/HSP90AB1/STAT3/HLA-DPA1/PPP3CC/IRF4/HLA-DOA/HLA-DQB1/IL2RB/AHR/CHUK/JAK1/IFNG/NFATC3/PPP3R1/MAPK10/IL1R1/IL23R/CD3E/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/RXRG/HLA-DRB1/HLA-DRB4/IL6/TBX21/IL17F/IL1RAP	104
KEGG	hsa04120	Ubiquitin mediated proteolysis	134/6408	142/8135	1.897e-07	2.347e-06	9.024e-07	UBE2U/SYVN1/RHOBTB2/UBE2K/UBA1/UBE4B/MDM2/HERC1/ANAPC1/UBE2I/TRIP12/ANAPC7/CUL3/UBE2G1/UBE2J2/UBC/UBE2Q1/UBOX5/KLHL9/ANAPC2/WWP2/ANAPC10/CUL7/FBXO2/STUB1/KEAP1/PIAS3/UBE2F/HERC2/SMURF2/RCHY1/RNF7/CDC27/UBE2R2/UBA7/CDC26/UBE2J1/UBE2L3/DDB2/TRAF6/ANAPC5/UBE2D2/BIRC2/UBE4A/MGRN1/UBE2D1/HERC4/UBE2C/PIAS4/UBR5/UBA52/ANAPC4/UBA3/CUL4B/DDB1/TRIM37/UBE2E3/BIRC6/XIAP/UBE3A/SMURF1/PRPF19/ANAPC13/BTRC/BRCA1/UBE2L6/CUL1/HUWE1/CBLB/PML/UBE2A/UBA2/ANAPC11/UBE2NL/KLHL13/FZR1/UBE2QL1/CDC16/UBE2E1/UBA6/UBE2N/BIRC7/CUL4A/SKP1/FBXW11/RBX1/CBLC/AIRE/ERCC8/FANCL/CDC34/UBE2Z/UBE2B/SOCS3/TRIM32/RHOBTB1/CBL/UBE2M/UBE2W/SOCS1/UBE2D3/HERC3/CUL2/FBXO4/UBE2S/UBE3C/NEDD4L/SAE1/UBE2D4/FBXW7/CUL5/MAP3K1/ANAPC16/SKP2/PPIL2/BIRC3/PIAS1/UBE2G2/UBE3B/ITCH/CDC23/RPS27A/UBE2O/VHL/WWP1/SIAH1/MID1/UBE2Q2/NEDD4/DET1/UBB/PIAS2/UBE2H/FBXW8	134
KEGG	hsa05220	Chronic myeloid leukemia	75/6408	76/8135	2.627e-07	3.133e-06	1.205e-06	BAD/AKT2/GRB2/E2F1/MDM2/GADD45B/PIK3CB/SHC1/HDAC1/STAT5B/SOS1/CCND1/MAP2K2/STAT5A/IKBKG/TGFB1/TGFB2/RUNX1/ARAF/PIK3CD/MAPK1/CTBP2/SHC3/AKT1/AKT3/CRKL/SMAD4/BRAF/RAF1/MAPK3/PIK3R1/CDKN1A/DDB2/BAK1/NFKBIA/SMAD3/BAX/HDAC2/HRAS/PIK3R2/BCL2L1/IKBKB/PIK3CA/POLK/GAB2/BCR/CDKN1B/RELA/MAP2K1/CDKN2A/NFKB1/SOS2/ABL1/E2F3/CRK/GADD45A/TGFBR2/GADD45G/KRAS/TGFBR1/CBL/PTPN11/CDK4/TP53/RB1/CTBP1/SHC2/NRAS/CHUK/CDK6/SHC4/PIK3R3/E2F2/MECOM/MYC	75
KEGG	hsa05214	Glioma	74/6408	75/8135	3.3e-07	3.801e-06	1.462e-06	AKT2/IGF1/GRB2/CAMK2G/E2F1/MDM2/GADD45B/PIK3CB/SHC1/PRKCB/SOS1/CALML6/CCND1/MAP2K2/ARAF/PIK3CD/MAPK1/SHC3/MTOR/AKT1/AKT3/PDGFRB/PTEN/BRAF/RAF1/MAPK3/PLCG2/PIK3R1/CDKN1A/CALM2/DDB2/BAK1/BAX/HRAS/PIK3R2/PIK3CA/CALM1/POLK/MAP2K1/CAMK2B/CDKN2A/IGF1R/SOS2/E2F3/GADD45A/CAMK1D/CALML4/GADD45G/CALML5/KRAS/PLCG1/EGF/PDGFB/CALM3/CALML3/CAMK2D/PRKCG/TGFA/CDK4/TP53/RB1/CAMK2A/PDGFA/SHC2/PRKCA/NRAS/CDK6/SHC4/CAMK1G/PIK3R3/E2F2/CAMK1/CAMK4/PDGFRA	74
KEGG	hsa04668	TNF signaling pathway	107/6408	112/8135	4.953e-07	5.514e-06	2.12e-06	IFNB1/MMP3/IRF1/AKT2/MMP14/ATF4/MAPK14/PIK3CB/BCL3/CEBPB/CREB3/TNFRSF1B/CFLAR/RIPK1/IKBKG/MLKL/RIPK3/JUNB/PIK3CD/TNFRSF1A/MAPK1/AKT1/TRADD/PGAM5/AKT3/TNFAIP3/ATF6B/FADD/MAPK9/FAS/MAPK3/CASP3/PIK3R1/CASP8/IL1B/MAPK11/NOD2/CREB5/TRAF2/VEGFC/NFKBIA/BIRC2/MAPK13/PIK3R2/IKBKB/PIK3CA/MAP3K5/TAB2/TNF/MAPK12/CXCL1/ICAM1/RPS6KA4/JUN/MAP2K4/MAP3K7/MAP2K6/RELA/JAG1/MAP2K1/TAB1/TAB3/CSF2/NFKB1/TRAF3/MAP2K7/CXCL3/SELE/MMP9/ATF2/EDN1/PTGS2/CREB3L4/TRAF1/DAB2IP/CREB3L2/FOS/MAPK8/LTA/CREB1/SOCS3/LIF/CASP10/DNM1L/MAP3K14/CCL5/RPS6KA5/CASP7/BIRC3/MAP3K8/IL18R1/TRAF5/ITCH/MAP2K3/CHUK/BAG4/PIK3R3/IL15/CCL20/CXCL6/MAPK10/CCL2/VCAM1/CSF1/CXCL5/IL6/CREB3L1	107
KEGG	hsa04152	AMPK signaling pathway	114/6408	120/8135	5.471e-07	5.894e-06	2.266e-06	ADIPOQ/GYS2/PCK1/ADIPOR2/PPP2R5D/PPP2R5C/AKT2/IGF1/PPP2CA/PIK3CB/PPP2R2C/RPTOR/STRADA/FBP1/CREB3/TSC1/EEF2/RPS6KB2/CCND1/PPP2R5B/CPT1C/HMGCR/PIK3CD/CFTR/PPP2R2D/MTOR/TSC2/AKT1/AKT1S1/PRKAB1/ADRA1A/PFKFB4/AKT3/MLYCD/IRS2/PFKP/RHEB/PIK3R1/STK11/CAB39L/CREB5/PPP2R2A/G6PC/RAB10/EIF4EBP1/HNF4A/PIK3R2/PRKAG1/PPP2R3C/CAMKK2/PIK3CA/RAB2A/CPT1B/PCK2/PRKAG2/CAB39/CD36/PRKAA1/PFKFB3/IRS1/TBC1D1/CPT1A/MAP3K7/GYS1/ULK1/IGF1R/CCNA2/PPP2R1A/SREBF1/PFKM/PFKFB2/PPP2R2B/PFKL/CRTC2/PPP2R5A/PPP2R3B/EEF2K/FOXO1/G6PC2/CREB3L4/FASN/CREB3L2/LEP/IRS4/ACACA/SIRT1/G6PC3/CREB1/ELAVL1/RAB11B/INSR/INS/RPS6KB1/PPP2CB/ADIPOR1/RAB14/SCD5/FOXO3/ACACB/PIK3R3/SCD/PPP2R1B/PDPK1/PPP2R5E/RAB8A/LEPR/PRKAG3/PPP2R3A/PRKAA2/SLC2A4/PPARG/CREB3L1/FBP2/PRKAB2	114
KEGG	hsa04380	Osteoclast differentiation	121/6408	128/8135	5.728e-07	5.979e-06	2.299e-06	IFNB1/NOX1/AKT2/SIRPA/GRB2/RAC1/IFNGR2/MAPK14/PIK3CB/BTK/SYK/PPP3R2/TYROBP/LILRB5/IKBKG/LILRB2/TYK2/NCF4/CALCR/TGFB1/FCGR2A/TGFB2/JUNB/NFATC1/NCF1/PIK3CD/IFNAR1/NCF2/TNFRSF1A/MAPK1/AKT1/LCP2/AKT3/LILRA2/LILRB3/PPP3CB/SPI1/SQSTM1/MAPK9/MAPK3/FYN/CYLD/RELB/PLCG2/PIK3R1/TREM2/IL1B/FOSL2/CSF1R/TRAF6/MAPK11/IFNGR1/TRAF2/NFKBIA/OSCAR/JUND/MAPK13/PIK3R2/IKBKB/LILRB4/PIK3CA/TAB2/IRF9/TNF/MAPK12/MITF/LILRA1/GAB2/JUN/NFKB2/STAT1/MAP3K7/STAT2/MAP2K6/RELA/TNFRSF11B/FCGR3B/MAP2K1/CYBA/FCGR2C/TAB1/TEC/SIRPB1/NFKB1/PPP3CA/FCGR1A/MAP2K7/TGFBR2/LCK/NFATC2/LILRA3/FOS/LILRB1/MAPK8/ACP5/ITGB3/LILRA6/FCGR2B/CREB1/TGFBR1/CTSK/SIRPG/SOCS3/IFNAR2/SOCS1/MAP3K14/PPP3CC/FCGR3A/CHUK/JAK1/PIK3R3/FOSB/IFNG/PPP3R1/MAPK10/IL1R1/BLNK/CSF1/CAMK4/PPARG/IL1A	121
KEGG	hsa04935	Growth hormone synthesis, secretion and action	113/6408	119/8135	6.631e-07	6.711e-06	2.58e-06	GHR/AKT2/IGF1/GRB2/PLCB2/ATF4/PRKACA/MAPK14/PIK3CB/SHC1/GNAQ/GHRH/STAT5B/CREB3/PRKCB/SOS1/MAP2K2/STAT5A/GNA11/CACNA1C/GNAI1/GNAI3/JUNB/PIK3CD/MAPK1/SHC3/MTOR/AKT1/EP300/GNAS/AKT3/ATF6B/ADCY8/CRKL/MAPK9/ITPR3/PLCB4/RAF1/MAPK3/IRS2/JAK2/PLCG2/BCAR1/PIK3R1/ADCY6/MAPK11/CREB5/GHRL/MAPK13/HRAS/PIK3R2/PIK3CA/ITPR2/MAPK12/ADCY4/GNAI2/PLCB3/MAP2K4/SSTR5/IRS1/STAT1/ADCY7/MAP2K6/PTK2/MAP2K1/SSTR3/SOS2/CRK/ATF2/CACNA1F/ITPR1/KRAS/CREB3L4/CREB3L2/FOS/PRKACB/SST/IRS4/PLCG1/MAPK8/CACNA1S/CREB1/ADCY9/SOCS3/ADCY3/SOCS1/PRKACG/PRKCG/POU1F1/SSTR1/IGFALS/STAT3/CACNA1D/MAP3K1/SOCS2/GHSR/PLCB1/SHC2/MAP2K3/PRKCA/NRAS/SHC4/PIK3R3/CREBBP/MAPK10/GH1/GH2/ADCY1/IGFBP3/ADCY2/CREB3L1/CSH1/GSK3B	113
KEGG	hsa04630	JAK-STAT signaling pathway	150/6408	162/8135	1.242e-06	1.21e-05	4.651e-06	IL12A/IFNA2/IFNB1/IL13RA2/TSLP/IL2/CNTF/IFNA1/IFNA13/GHR/PTPN6/AKT2/IFNE/PTPN2/GRB2/IFNGR2/PIK3CB/IL10RA/AOX1/IL2RG/IL20/STAT5B/STAT6/SOS1/CCND1/STAT5A/EPOR/TYK2/IL22RA1/PIK3CD/IL27RA/IFNAR1/MCL1/MTOR/AKT1/EP300/AKT3/JAK3/PDGFRB/PIAS3/STAM/IL6R/IL13RA1/RAF1/CSF3R/IL22/IL10/CISH/JAK2/CCND3/PIK3R1/CDKN1A/IL12RB1/IL2RA/LIFR/IFNGR1/CSF2RB/STAM2/HRAS/PIK3R2/BCL2L1/IL23A/PIAS4/PIK3CA/IL4R/IRF9/IL12RB2/IL11RA/IL6ST/IL10RB/STAT1/STAT2/IL20RA/CRLF2/CSF2/IFNA8/SOS2/OSM/IL21R/CCND2/FHL1/IL3/SOCS5/CSF3/IL9R/IL4/LEP/CSF2RA/IL21/IL19/EGF/IL12B/SOCS3/PDGFB/IFNAR2/IL3RA/IL13/SOCS1/SOCS4/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/IL20RB/IL17D/LIF/PRLR/MPL/PTPN11/STAT4/STAT3/CNTFR/SOCS2/IL7R/EPO/PDGFA/PIAS1/IL2RB/BCL2/JAK1/GFAP/PIK3R3/IL15/CREBBP/IFNG/IL5RA/SOCS7/GH1/GH2/IL9/CTF1/THPO/IL23R/IL15RA/LEPR/IFNW1/IFNA17/OSMR/PIM1/IL7/IL24/IL6/PDGFRA/CSH1/MYC/PIAS2	150
KEGG	hsa04144	Endocytosis	226/6408	251/8135	1.268e-06	1.21e-05	4.651e-06	CAPZA3/GRK7/HLA-E/PARD6A/ARFGEF1/CYTH1/CHMP4A/GBF1/VPS4A/SNX6/EHD1/MDM2/VPS26B/SNX12/VPS35/VPS25/PDCD6IP/RHOA/IL2RG/ARPC4/ARPC5/IQSEC1/TSG101/HLA-B/HLA-C/ARRB1/VPS29/CLTC/FOLR2/ACAP1/ARPC1A/CXCR1/ACAP3/VPS4B/SNX2/RAB11FIP4/ARPC1B/ACTR3B/AGAP3/ARPC2/ARFGAP2/HSPA6/ZFYVE16/PSD4/SH3GL2/SMAD2/SH3GL1/ZFYVE9/STAMBP/VPS37B/RAB4A/CHMP2A/SPG21/ACTR3/ARRB2/AGAP4/AGAP6/RAB5A/EPN1/WASL/CYTH4/PLD2/PIP5K1C/GRK5/ARF4/SNX32/ARF1/STAM/ARAP3/WIPF1/EPN2/GRK6/ARFGAP3/HLA-A/ARPC5L/ARPC3/CHMP4B/ARAP1/CHMP6/SMURF2/AP2A2/AGAP5/USP8/WIPF3/RAB11A/ASAP1/IL2RA/EHD2/CHMP1A/SNX4/TRAF6/HGS/AGAP2/CLTCL1/VPS28/STAM2/SNX1/PLD1/SMAD3/RAB10/AP2M1/HRAS/KIF5C/ARF3/RAB35/SNX3/SH3KBP1/SH3GLB2/GIT1/RAB31/HSPA8/ACAP2/RAB11FIP5/HSPA1L/EHD4/HSPA1A/HLA-G/CHMP2B/ARF6/CDC42/RNF41/LDLRAP1/KIF5B/VPS37C/VPS45/SMURF1/ARFGAP1/SMAP1/SH3GLB1/RUFY1/PSD/RAB11FIP2/HLA-F/RABEP1/GIT2/CLTA/CAPZB/LDLR/DNM1/CXCR4/CLTB/RAB5B/PRKCZ/EHD3/DNM2/VTA1/ZFYVE27/SNX5/FGFR4/TFRC/RAB7A/CAPZA1/CBLB/PML/ARF5/GRK4/CXCR2/CYTH3/IGF1R/PARD3/VPS36/PIP5K1A/PSD3/SNF8/IQSEC2/EPS15/ARAP2/SMAP2/CHMP5/VPS26A/TGFBR2/IGF2R/BIN1/PIP5KL1/FGFR2/SH3GL3/RAB11FIP3/CBLC/HSPA1B/WIPF2/RAB5C/ASAP3/PIP5K1B/TGFBR1/PARD6G/FOLR3/IQSEC3/AP2S1/CBL/RAB11B/CYTH2/AP2A1/SRC/AP2B1/DAB2/PSD2/EPS15L1/RAB22A/CHMP7/NEDD4L/RAB11FIP1/RUFY2/GRK1/VPS37A/ACTR2/ARFGEF2/IL2RB/FOLR1/ITCH/VPS37D/CAV2/ASAP2/RAB8A/CHMP1B/EEA1/WWP1/CHMP4C/PARD6B/PDGFRA/KIF5A/AMPH/NEDD4/HSPA2/AGAP9/DNM3/CAV3	226
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	86/6408	89/8135	1.379e-06	1.279e-05	4.919e-06	PTPN6/AKT2/IFNGR2/MAPK14/PIK3CB/MAP3K3/NFKBIB/PPP3R2/MYD88/RPS6KB2/MAP2K2/IKBKG/CSNK2B/PDCD1/NFKBIE/NFATC1/PIK3CD/MAPK1/TLR9/MTOR/AKT1/AKT3/CD4/PPP3CB/PTEN/TICAM1/RAF1/MAPK3/JAK2/PIK3R1/TRAF6/MAPK11/IFNGR1/TIRAP/ALK/NFKBIA/MAPK13/HRAS/PIK3R2/IKBKB/PIK3CA/MAPK12/BATF3/CSNK2A2/JUN/BATF/STAT1/MAP2K6/RELA/CD3D/LAT/CSNK2A1/MAP2K1/NFKB1/PPP3CA/HIF1A/PRKCQ/RASGRP1/TLR2/LCK/NFATC2/ZAP70/KRAS/FOS/TICAM2/PLCG1/EGF/EML4/CD274/CD3G/BATF2/PTPN11/STAT3/RPS6KB1/PPP3CC/MAP2K3/CD28/NRAS/CHUK/JAK1/PIK3R3/IFNG/NFATC3/PPP3R1/TLR4/CD3E	86
KEGG	hsa05165	Human papillomavirus infection	293/6408	331/8135	1.707e-06	1.541e-05	5.925e-06	COL6A6/FZD10/IFNA2/IFNB1/TNN/WNT2/DLG2/IFNA1/IFNA13/HLA-E/ATP6V1H/PARD6A/WNT9B/IRF1/PPP2R5D/BAD/PPP2R5C/UBR4/ITGA11/AKT2/PPP2CA/GRB2/E2F1/MDM2/PRKACA/FZD2/SLC9A3R1/PIK3CB/ATP6V0D1/ITGA5/WNT3/PPP2R2C/HDAC1/PXN/PSMC1/CREB3/HLA-B/ATP6V0A1/ITGB4/HLA-C/WNT7B/DVL1/TSC1/SOS1/ATP6V0E1/ATP6AP1/RPS6KB2/ITGA2/CCND1/MAP2K2/THBS4/WNT7A/PTGER4/IKBKG/PPP2R5B/ATP6V1B2/ATP6V0B/WNT8B/TYK2/ATP6V1E2/DVL2/TBK1/MX2/PIK3CD/IFNAR1/APC2/BCAP31/TNFRSF1A/MAPK1/NOTCH1/PPP2R2D/MTOR/TSC2/AKT1/EP300/LLGL1/GNAS/TRADD/HES6/AKT3/TADA3/PDGFRB/PSEN1/WNT16/FADD/PTEN/ATP6V1E1/HLA-A/TICAM1/ATP6V1D/VWF/RAF1/LAMB1/FAS/MAPK3/HES4/CASP3/TCIRG1/LAMA3/CSNK1A1/RHEB/MPP5/CCND3/PIK3R1/LAMA1/CASP8/CDKN1A/ITGA2B/VTN/LAMA2/CREB5/PPP2R2A/THBS1/ITGB7/WNT10B/BAK1/IRF3/TBPL1/MFNG/EIF4EBP1/BAX/MAGI1/HDAC2/FZD1/TNXB/HRAS/PIK3R2/IKBKB/PPP2R3C/PIK3CA/LLGL2/IRF9/TNF/WNT1/THBS3/ATP6V1B1/ATP6V1F/ATR/HLA-G/ITGA8/UBE3A/RFNG/CDC42/COL6A1/ATP6V1C1/TCF7/RBPJL/ITGB5/HLA-F/MAML1/CDKN1B/NFX1/STAT1/CHD4/TERT/HES1/PRKCZ/STAT2/PTK2/RELA/JAG1/RBL2/MAP2K1/ATP6V0E2/ATP6V0A2/VEGFA/ITGA9/ITGAV/IFNA8/ATM/DLG1/TUBG2/NFKB1/PARD3/SOS2/CCNA2/WNT8A/TRAF3/ATP6V0C/IKBKE/PPP2R1A/ATP6V1A/LFNG/TCF7L2/PPP2R2B/COL9A3/ATP6V0D2/PPP2R5A/FZD9/PPP2R3B/CCND2/ITGA7/FOXO1/ITGA10/MAML2/EIF2AK2/CDK2/KRAS/PTGS2/COL9A1/CREB3L4/CREB3L2/PRKACB/ITGA4/HEYL/EGF/ITGB3/COL4A3/CREB1/PARD6G/COL4A5/RBPJ/IFNAR2/HES5/CCNE2/ISG15/OASL/COL9A2/ATP6V1G3/WNT4/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PRKACG/MX1/IFNA16/ITGB1/COMP/CCNE1/SCRIB/LAMC1/COL4A2/HEY1/THBS2/CDK4/RPS6KB1/TP53/RB1/PPP2CB/CRB3/COL1A1/COL4A6/DVL3/WNT5B/CHAD/LAMA5/CTNNB1/HES7/APC/COL6A3/AXIN1/FZD6/NRAS/LAMB2/ITGB8/CHUK/LAMC3/CDK6/MAML3/JAK1/FASLG/NOTCH2/PIK3R3/FN1/HES2/RBL1/PPP2R1B/CREBBP/LAMC2/ATP6V1G2/PPP2R5E/WNT5A/TUBG1/LAMB4/FZD8/FZD3/COL4A1/LAMA4/IFNA17/TBP/PARD6B/PPP2R3A/ITGA3/ATP6V0A4/CREB3L1/FZD7/COL6A2/SPP1/GSK3B	293
KEGG	hsa04625	C-type lectin receptor signaling pathway	99/6408	104/8135	2.379e-06	2.091e-05	8.039e-06	IL12A/IL2/CLEC4M/PAK1/IRF1/AKT2/CD209/MDM2/MAPK14/PIK3CB/RHOA/BCL3/SYK/PPP3R2/PLK3/CARD9/CALML6/IKBKG/NFATC1/PIK3CD/LSP1/MAPK1/AKT1/AKT3/PPP3CB/MAPK9/ITPR3/RAF1/MAPK3/RRAS/IL10/CYLD/RELB/PLCG2/PIK3R1/CASP8/CALM2/IL1B/MAPK11/PYCARD/NFKBIA/MAPK13/HRAS/PIK3R2/IKBKB/IL23A/FCER1G/PIK3CA/IRF9/TNF/ITPR2/MAPK12/CLEC7A/CASP1/CALM1/MAPKAPK2/JUN/NFKB2/CLEC4E/CLEC4D/MALT1/STAT1/STAT2/RELA/CBLB/NLRP3/NFKB1/PRKCD/IKBKE/PPP3CA/KSR1/CALML4/NFATC2/CALML5/ITPR1/KRAS/PTGS2/MAPK8/IL12B/BCL10/CALM3/IL17D/SRC/CALML3/MAP3K14/PTPN11/PPP3CC/NFATC4/NRAS/CHUK/CLEC1B/PIK3R3/NFATC3/PPP3R1/MAPK10/MRAS/CCL17/IL6/RRAS2	99
KEGG	hsa05145	Toxoplasmosis	106/6408	112/8135	2.516e-06	2.155e-05	8.284e-06	IL12A/BAD/AKT2/CASP9/IFNGR2/MAPK14/CD40/IL10RA/NFKBIB/MYD88/IKBKG/PIK3R5/GNAI1/GNAI3/TYK2/TGFB1/TGFB2/HSPA6/IRAK1/TNFRSF1A/MAPK1/AKT1/AKT3/PPIF/MAPK9/LAMB1/MAPK3/CASP3/IL10/LAMA3/JAK2/LAMA1/CASP8/IRAK4/TRAF6/MAPK11/LAMA2/IFNGR1/NFKBIA/BIRC2/MAPK13/BCL2L1/IKBKB/TAB2/TNF/HSPA8/LY96/MAPK12/HSPA1L/HSPA1A/XIAP/GNAI2/LDLR/ALOX5/IL10RB/STAT1/MAP3K7/HLA-DMB/MAP2K6/RELA/TAB1/GNAO1/NFKB1/TLR2/BIRC7/CYCS/HLA-DMA/HSPA1B/MAPK8/IL12B/CD40LG/SOCS1/HLA-DRA/ITGB1/PIK3CG/LAMC1/STAT3/PIK3R6/HLA-DPA1/BIRC3/HLA-DOA/CIITA/LAMA5/HLA-DQB1/MAP2K3/IRGM/LAMB2/BCL2/CHUK/LAMC3/JAK1/IFNG/LAMC2/PDPK1/MAPK10/LAMB4/TLR4/HLA-DOB/LAMA4/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/HSPA2	106
KEGG	hsa05160	Hepatitis C	145/6408	157/8135	2.859e-06	2.388e-05	9.18e-06	IFNA2/IFNB1/IFNA1/IFNA13/CLDN8/BAD/AKT2/PPP2CA/PPARA/GRB2/CASP9/E2F1/PIK3CB/PPP2R2C/CFLAR/SOS1/RIPK1/CCND1/MAP2K2/IKBKG/CLDN1/TYK2/TBK1/MX2/ARAF/PIK3CD/IFNAR1/CLDN3/TNFRSF1A/RXRA/MAPK1/PPP2R2D/AKT1/TRADD/AKT3/YWHAB/FADD/TICAM1/BRAF/RAF1/FAS/MAPK3/CASP3/EIF2S1/CLDN5/PIK3R1/CASP8/CDKN1A/TRAF6/PSME3/PPP2R2A/TRAF2/MAVS/BAK1/IRF3/NFKBIA/BAX/BID/HRAS/PIK3R2/IKBKB/RNASEL/CLDN15/YWHAQ/PIK3CA/IRF9/TNF/YWHAZ/EIF2AK1/IRF7/YWHAG/LDLR/STAT1/EIF2AK3/CLDN19/STAT2/RELA/MAP2K1/DDX58/YWHAE/IFNA8/CLDN9/CLDN2/NFKB1/SOS2/TRAF3/IKBKE/E2F3/PPP2R1A/APAF1/NR1H3/PPP2R2B/CLDN6/CLDN23/CYCS/CD81/EIF2AK2/CDK2/KRAS/EGF/EIF3E/CLDN4/SOCS3/IFNAR2/SCARB1/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/MX1/IFNA16/STAT3/CDK4/TP53/RB1/PPP2CB/IFIT1/OAS1/CLDN11/CLDN7/PIAS1/CTNNB1/OAS3/RSAD2/NRAS/CHUK/CLDN16/CDK6/JAK1/FASLG/PIK3R3/E2F2/PPP2R1B/IFNG/IFNA17/OAS2/EIF2AK4/CLDN17/YWHAH/MYC/GSK3B/CLDN14	145
KEGG	hsa04936	Alcoholic liver disease	132/6408	142/8135	3.031e-06	2.469e-05	9.492e-06	IL12A/ADIPOQ/IFNA2/IFNB1/ADH1B/IFNA1/IFNA13/ADH7/ADIPOR2/AKT2/PPARA/MAPK14/IL17RA/MYD88/RIPK1/CCND1/IKBKG/CPT1C/TBK1/TRA2B/IRAK1/TNFRSF1A/ALDH9A1/AKT1/PRKAB1/TRADD/ADH5/AKT3/ACADVL/MLYCD/FADD/MAPK9/TICAM1/IL17A/FAS/CASP3/CASP8/C2/IL1B/CD14/IRAK4/TRAF6/MAPK11/ACOX1/ADH1A/TIRAP/IRF3/NFKBIA/MAPK13/IKBKB/PRKAG1/CAMKK2/MAP3K5/CPT1B/TAB2/TNF/LY96/MAPK12/PRKAG2/CXCL1/C5AR1/ALDH2/TCF7/MAP2K4/PRKAA1/CPT1A/ALDH1B1/MAP3K7/MAP2K6/RELA/C1QB/TAB1/C3/TAB3/IFNA8/NFKB1/LPIN3/ALDH7A1/TRAF3/IKBKE/SREBF1/MAP2K7/CXCL3/TCF7L2/C5/C1QA/FOXO1/C3AR1/FASN/LPIN1/ACOX3/MAPK8/ACACA/LPIN2/ALDH3A2/SIRT1/IL12B/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/NOX4/MAP3K14/IL17RC/ADIPOR1/SCD5/CTNNB1/ACADM/MAP2K3/FOXO3/CHUK/FASLG/ACACB/C4A/C4B/SCD/CYP2E1/C1QC/MAPK10/TLR4/TRA2A/IFNA17/PRKAG3/PRKAA2/IL6/ADH1C/PRKAB2/GSK3B	132
KEGG	hsa05142	Chagas disease	97/6408	102/8135	3.505e-06	2.787e-05	1.072e-05	IL12A/IFNB1/IL2/AKT2/PPP2CA/PLCB2/IFNGR2/MAPK14/PIK3CB/GNA15/GNAQ/PPP2R2C/CFLAR/MYD88/IKBKG/GNA11/GNAI1/GNAI3/TGFB1/TGFB2/PIK3CD/IRAK1/SMAD2/TNFRSF1A/MAPK1/TLR9/PPP2R2D/AKT1/GNAS/AKT3/FADD/MAPK9/PLCB4/TICAM1/FAS/MAPK3/IL10/PIK3R1/CASP8/IL1B/IRAK4/TRAF6/MAPK11/IFNGR1/PPP2R2A/NFKBIA/MAPK13/PIK3R2/IKBKB/PIK3CA/TNF/MAPK12/GNAI2/PLCB3/JUN/MAP2K4/RELA/CD3D/C1QB/C3/GNAO1/NFKB1/PPP2R1A/PPP2R2B/TLR2/TGFBR2/C1QA/FOS/MAPK8/SERPINE1/TGFBR1/IL12B/CD3G/KNG1/TLR6/CALR/CCL5/PPP2CB/ACE/PLCB1/CHUK/FASLG/PIK3R3/PPP2R1B/C1QC/IFNG/MAPK10/CCL2/TLR4/CD3E/ADCY1/CCL3/CCL3L1/CCL3L3/BDKRB2/IL6/GNAL	97
KEGG	hsa04140	Autophagy - animal	131/6408	141/8135	3.597e-06	2.794e-05	1.074e-05	PIK3C3/BAD/AKT2/PPP2CA/HMGB1/PRKACA/PIK3CB/UVRAG/RRAGA/RRAGD/MTMR14/RPTOR/PIK3R4/TSC1/WIPI2/CFLAR/RAB1A/GABARAP/RPS6KB2/MAP2K2/MTMR3/MAP1LC3B/LAMP2/ATG5/TBK1/PIK3CD/MAPK1/MLST8/SNAP29/MTOR/ZFYVE1/TSC2/AKT1/AKT1S1/AKT3/ATG12/SMCR8/ATG4A/PTEN/SQSTM1/RB1CC1/MAPK9/ATG16L2/RAF1/MAPK3/ATG4D/RRAS/EIF2S1/IRS2/RHEB/PIK3R1/STK11/MAP1LC3A/TRAF6/RRAGC/AMBRA1/C9orf72/LAMP1/DAPK3/ATG9A/ATG7/HRAS/PIK3R2/BCL2L1/CTSB/ATG3/CAMKK2/PIK3CA/GABARAPL1/GABARAPL2/ATG4B/BECN1/ATG2B/IGBP1/SH3GLB1/MTMR4/PRKAA1/IRS1/EIF2AK3/MAP3K7/CTSD/MAP2K1/ULK1/ATG2A/RAB7A/STX17/MAP1LC3C/RRAGB/IGF1R/PRKCD/ULK2/RAB39B/HIF1A/PRKCQ/WIPI1/BNIP3/DAPK2/VAMP8/WDR41/ITPR1/KRAS/RAB7B/PRKACB/IRS4/MAPK8/TP53INP2/ERN1/PRKACG/ATG9B/INS/RPS6KB1/PPP2CB/MAP1LC3B2/RAB33B/NRBF2/ATG4C/NRAS/BCL2/PIK3R3/TANK/PDPK1/MAPK10/DDIT4/RAB8A/PRAP1/MRAS/ATG10/PRKAA2/DAPK1/EIF2AK4/RRAS2	131
KEGG	hsa04912	GnRH signaling pathway	89/6408	93/8135	3.838e-06	2.913e-05	1.12e-05	PTK2B/MMP14/GRB2/CAMK2G/PLCB2/ATF4/PRKACA/MAPK14/MAP3K3/GNAQ/PRKCB/PLA2G4D/SOS1/CALML6/MAP2K2/GNA11/CACNA1C/MAPK1/PLA2G4C/GNAS/PLD2/ELK1/ADCY8/MAPK9/ITPR3/PLCB4/RAF1/MAPK3/GNRH1/CALM2/ADCY6/MAPK11/PLD1/MAPK13/HRAS/JMJD7-PLA2G4B/PLA2G4B/ITPR2/MAPK12/ADCY4/CALM1/CGA/MAPK7/CDC42/PLCB3/JUN/MAP2K4/ADCY7/MAP2K6/MAP2K1/CAMK2B/PLA2G4F/PRKCD/SOS2/MAP2K7/CALML4/MAP3K4/CALML5/CACNA1F/ITPR1/KRAS/MAP3K2/PRKACB/MAPK8/CACNA1S/ADCY9/MMP2/ADCY3/CALM3/PRKACG/SRC/CALML3/CAMK2D/CACNA1D/CAMK2A/MAP3K1/PLCB1/MAP2K3/PRKCA/NRAS/PLA2G4A/HBEGF/MAPK10/ADCY1/FSHB/GNRHR/ADCY2/LHB/GNRH2	89
KEGG	hsa04658	Th1 and Th2 cell differentiation	88/6408	92/8135	4.684e-06	3.401e-05	1.308e-05	IL12A/IL2/IFNGR2/MAPK14/IL2RG/NFKBIB/STAT5B/PPP3R2/STAT6/STAT5A/IKBKG/TYK2/NFKBIE/NFATC1/MAPK1/NOTCH1/JAK3/CD4/PPP3CB/MAPK9/MAPK3/JAK2/IL12RB1/IL2RA/MAPK11/IFNGR1/NFKBIA/MAPK13/IKBKB/IL4R/MAPK12/IL12RB2/JAG2/RBPJL/JUN/MAML1/STAT1/HLA-DMB/RELA/CD3D/LAT/JAG1/DLL3/NFKB1/PPP3CA/PRKCQ/LCK/NFATC2/ZAP70/MAML2/IL4/FOS/HLA-DMA/PLCG1/MAPK8/GATA3/IL12B/RBPJ/CD3G/IL13/HLA-DRA/DLL1/STAT4/HLA-DPA1/PPP3CC/RUNX3/HLA-DOA/HLA-DQB1/IL2RB/CHUK/MAML3/JAK1/NOTCH2/IFNG/NFATC3/PPP3R1/MAPK10/CD3E/HLA-DOB/DLL4/HLA-DQA1/HLA-DQA2/MAF/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/TBX21	88
KEGG	hsa05222	Small cell lung cancer	88/6408	92/8135	4.684e-06	3.401e-05	1.308e-05	AKT2/CASP9/E2F1/ZBTB17/GADD45B/PIK3CB/CKS1B/ITGA2/CCND1/IKBKG/PIK3CD/RXRA/TRAF4/AKT1/AKT3/PTEN/LAMB1/CASP3/LAMA3/PIK3R1/LAMA1/CDKN1A/ITGA2B/DDB2/TRAF6/LAMA2/TRAF2/BAK1/NFKBIA/BAX/BIRC2/PIK3R2/BCL2L1/IKBKB/PIK3CA/XIAP/POLK/CDKN1B/RXRB/PTK2/RELA/ITGAV/NFKB1/TRAF3/E2F3/GADD45A/APAF1/CDKN2B/GADD45G/BIRC7/CYCS/CDK2/PTGS2/TRAF1/COL4A3/COL4A5/CCNE2/CKS2/ITGB1/CCNE1/LAMC1/COL4A2/CDK4/TP53/RB1/COL4A6/SKP2/BIRC3/LAMA5/TRAF5/FHIT/LAMB2/BCL2/CHUK/LAMC3/CDK6/PIK3R3/E2F2/FN1/LAMC2/LAMB4/COL4A1/RARB/LAMA4/RXRG/ITGA3/MAX/MYC	88
KEGG	hsa05418	Fluid shear stress and atherosclerosis	129/6408	139/8135	5.06e-06	3.596e-05	1.383e-05	CDH5/PLAT/NOX1/AKT2/ARHGEF2/ACTG1/RAC1/MAPK14/PIK3CB/RHOA/MAP2K5/RAC2/CALML6/IKBKG/HSP90B1/MGST3/NCF1/PIK3CD/NCF2/TNFRSF1A/GSTA3/GPC1/AKT1/AKT3/KEAP1/TXN/SQSTM1/MAPK9/NOS3/PIK3R1/ITGA2B/CALM2/IL1B/MAPK11/GSTO1/NQO1/ACTB/MAPK13/PIK3R2/IKBKB/ACVR2B/PIAS4/PIK3CA/MAP3K5/TNF/MAPK12/CALM1/MEF2A/MAPK7/ICAM1/SUMO1/JUN/MAP2K4/SUMO3/PRKAA1/MAP3K7/GSTT1/PRKCZ/MAP2K6/PTK2/RELA/CYBA/VEGFA/ITGAV/TXN2/HSP90AA1/NFKB1/NFE2L2/IL1R2/DUSP1/ACVR1/PECAM1/MAP2K7/CALML4/SELE/MMP9/EDN1/CALML5/MEF2C/FOS/SUMO2/MAPK8/SDC2/SDC4/ITGB3/SUMO4/GSTO2/MMP2/PDGFB/CALM3/MGST1/GSTP1/SRC/CALML3/HSP90AB1/GSTT2/KDR/TP53/SDC1/GSTM3/GSTM4/MGST2/GSTM1/PDGFA/CTNNB1/BMPR2/NPPC/BMPR1B/BCL2/CHUK/GSTM2/CAV2/KLF2/PIK3R3/IFNG/MAPK10/CCL2/IL1R1/VCAM1/ACVR2A/GSTA1/BMPR1A/HMOX1/THBD/PRKAA2/GSTM5/TRPV4/IL1A/CAV3	129
KEGG	hsa04020	Calcium signaling pathway	215/6408	240/8135	5.833e-06	4.059e-05	1.56e-05	FGF5/LHCGR/GRPR/SLC25A31/RYR3/CASQ2/HTR2C/CHRM2/DRD5/FGF1/ADRA1D/PTK2B/HRH1/PLCD1/PTAFR/ADORA2A/TNNC2/CAMK2G/PLCB2/PRKACA/STIM1/GNA15/GNAQ/ITPKC/PDE1A/PPP3R2/PRKCB/CASQ1/ITPKB/FGF3/ATP2A2/CALML6/PHKA2/GNA11/FGF18/CACNA1C/SLC25A4/HRH2/VDAC2/TACR3/MYLK2/TRDN/P2RX3/ADORA2B/GNAS/ADRA1A/PDGFRB/PPIF/ADCY8/PPP3CB/PHKG2/ITPR3/PLCB4/ORAI3/ATP2A3/NOS3/OXTR/PLCG2/HTR6/RET/VDAC3/CALM2/PDE1B/ATP2B2/FGF23/PHKB/VEGFC/ATP2B1/LTB4R2/PLN/PTGFR/MST1/ITPR2/CHRM3/ADCY4/HTR2A/SLC25A5/F2R/TPCN1/NTRK3/CALM1/TNNC1/FLT4/PLCB3/P2RX4/CACNA1H/HTR2B/CXCR4/DRD1/ADCY7/FGF10/ORAI1/FGFR4/CAMK2B/AGTR1/HGF/NTRK1/PLCD3/VEGFA/ASPH/VEGFB/MYLK3/CD38/PPP3CA/FLT1/HTR7/CAMK1D/P2RX7/PLCZ1/GRIN2C/FGF6/CALML4/MST1R/P2RX6/ATP2B3/CALML5/CACNA1F/ITPR1/ATP2B4/P2RX1/PDGFD/FGF7/GRIN1/FGFR2/FGF4/PRKACB/HTR5A/PLCG1/TBXA2R/ITPKA/CACNA1I/FGF16/EGF/RYR1/CACNA1S/CACNA1E/PHKG1/CHRNA7/SLC8A3/ADCY9/MCOLN2/PDGFB/ADCY3/MYLK/PLCD4/CALM3/MCOLN3/GRIN2D/PRKACG/PDGFC/SLC8A1/CALML3/ADRB2/CAMK2D/FGF17/PRKCG/TACR2/CCKBR/KDR/PPP3CC/SPHK2/CACNA1D/CAMK2A/PHKA1/HRC/CHRM5/CACNA1B/CHRM1/CYSLTR1/FGF22/AVPR1A/FGF2/ERBB3/GDNF/PDGFA/MCOLN1/ERBB4/FGF19/TACR1/PLCB1/FGFR1/TPCN2/EDNRA/TRHR/NTRK2/PRKCA/SPHK1/FGF20/CAMK1G/STIM2/PLCE1/GRIN2A/ADRB1/PPP3R1/CACNA1G/EDNRB/CAMK1/ADCY1/PTGER1/SLC25A6/FGF9/MET/PTGER3/RYR2/CAMK4/VDAC1/ORAI2/BDKRB2/PDGFRA/ADCY2/BDKRB1/P2RX5/PDE1C/GNAL/NGF	215
KEGG	hsa05223	Non-small cell lung cancer	70/6408	72/8135	6.67e-06	4.547e-05	1.748e-05	RASSF5/BAD/AKT2/GRB2/CASP9/E2F1/GADD45B/PIK3CB/STAT5B/PRKCB/SOS1/CCND1/MAP2K2/STAT5A/ARAF/PIK3CD/RXRA/MAPK1/AKT1/AKT3/JAK3/BRAF/RAF1/MAPK3/PLCG2/PIK3R1/RET/CDKN1A/DDB2/BAK1/ALK/BAX/HRAS/PIK3R2/KIF5C/PIK3CA/POLK/KIF5B/RXRB/STK4/MAP2K1/HGF/CDKN2A/SOS2/E2F3/GADD45A/GADD45G/RASSF1/KRAS/PLCG1/EGF/EML4/PRKCG/TGFA/STAT3/CDK4/TP53/RB1/FHIT/PRKCA/NRAS/FOXO3/CDK6/PIK3R3/E2F2/PDPK1/RARB/MET/RXRG/KIF5A	70
KEGG	hsa05135	Yersinia infection	127/6408	137/8135	7.103e-06	4.745e-05	1.824e-05	IFNB1/IL2/PTK2B/AKT2/ACTG1/RAC1/MAPK14/PIK3CB/ITGA5/RHOA/GNAQ/ARPC4/ARPC5/PXN/ARHGEF1/RAC2/VAV1/RHOG/MYD88/NLRC4/MAP2K2/ARPC1A/IKBKG/WAS/ARPC1B/FCGR2A/ACTR3B/TBK1/ARPC2/NFATC1/PIK3CD/IRAK1/RPS6KA1/ELMO2/MAPK1/LIMK1/ACTR3/AKT1/LCP2/WASL/AKT3/PIP5K1C/CD4/RPS6KA3/WIPF1/CRKL/MAPK9/ARPC5L/ARPC3/TICAM1/ARHGEF7/MAPK3/ROCK1/IL10/WIPF3/BCAR1/PIK3R1/IL1B/IRAK4/TRAF6/MAPK11/PYCARD/TRAF2/IRF3/NFKBIA/ACTB/MAPK13/PIK3R2/IKBKB/PIK3CA/TAB2/TNF/MAPK12/VAV2/CASP1/ARF6/CDC42/JUN/MAP2K4/GIT2/ROCK2/MAP3K7/SKAP2/MAP2K6/PTK2/PKN1/RELA/LAT/MAP2K1/TAB1/BAIAP2/RPS6KA2/PKN2/NLRP3/NFKB1/PIP5K1A/CRK/MAP2K7/LCK/NFATC2/ZAP70/FOS/ITGA4/ELMO1/PLCG1/MAPK8/WIPF2/PIP5K1B/ITGB1/SRC/IL18/MEFV/ACTR2/WASF2/MAP2K3/CD8B/CHUK/PIK3R3/FN1/RPS6KA6/DOCK1/NFATC3/MAPK10/CCL2/TLR4/IL6/GSK3B	127
KEGG	hsa04062	Chemokine signaling pathway	174/6408	192/8135	7.989e-06	5.232e-05	2.012e-05	GNG13/GRK7/CCL25/PAK1/PTK2B/BAD/AKT2/XCR1/GNG5/GRB2/PLCB2/PRKACA/RAC1/PIK3CB/SHC1/GNB1/RHOA/GNAQ/NFKBIB/GNG2/STAT5B/PXN/RAC2/PRKCB/VAV1/ARRB1/GNG10/SOS1/CCL14/CCL15/CXCR1/IKBKG/PIK3R5/GNAI1/CXCL16/GNAI3/WAS/NCF1/PIK3CD/MAPK1/GSK3A/SHC3/ARRB2/AKT1/DOCK2/AKT3/JAK3/GRK5/GNGT2/ADCY8/GRK6/CRKL/PLCB4/BRAF/RAF1/MAPK3/GNB2/ROCK1/FGR/JAK2/PLCG2/CCR1/BCAR1/PIK3R1/ADCY6/NFKBIA/GNB5/HRAS/PIK3R2/IKBKB/PIK3CA/RAP1A/CXCR3/ADCY4/VAV2/CCR2/HCK/CCL28/CXCL1/GNAI2/CDC42/PLCB3/LYN/STAT1/ROCK2/PREX1/GNB3/CXCR4/ADCY7/CCL24/GNG3/PRKCZ/STAT2/PTK2/RELA/MAP2K1/RASGRP2/CCL19/GRK4/CXCR2/GNG7/NFKB1/PARD3/GNG11/PRKCD/SOS2/RAP1B/CRK/CXCL3/KRAS/CCL27/GNG8/PRKACB/ELMO1/PLCG1/CX3CR1/CXCL13/CCL26/ADCY9/GNB4/GNGT1/CCL21/GNG12/ADCY3/PRKACG/TIAM1/SRC/CCL4/PIK3CG/CCL5/CCL1/STAT3/CXCR5/PIK3R6/CCR7/GRK1/PPBP/CCL7/CCL23/ITK/CXCL11/PLCB1/SHC2/CCL18/NRAS/FOXO3/CHUK/SHC4/PIK3R3/CCR10/CXCR6/CCL20/CCL16/CXCL6/CCL13/CCL2/PF4V1/XCL1/XCL2/ADCY1/CCL17/GNG4/CXCL14/CCR4/CCL3/CCL3L1/CCL3L3/CXCL5/CCL11/PF4/ADCY2/CXCL12/CCR6/GSK3B	174
KEGG	hsa04810	Regulation of actin cytoskeleton	196/6408	218/8135	8.394e-06	5.392e-05	2.073e-05	FGF5/CHRM2/FGF1/PAK1/ITGB2/ITGA11/DIAPH1/ACTG1/CFL1/IQGAP1/RAC1/GNA13/MYH9/PIK3CB/ITGA5/RHOA/ARPC4/ARPC5/NCKAP1L/PXN/ARHGEF1/VCL/ITGB4/RAC2/VAV1/FGF3/MSN/SOS1/ITGA2/MAP2K2/ARPC1A/ACTN1/FGF18/ARHGEF6/ITGAM/LPAR2/SPATA13/ARPC1B/ACTR3B/CYFIP2/ARPC2/ARAF/PIK3CD/APC2/MYLK2/MAPK1/LIMK1/FGD3/ACTR3/EZR/WASL/CYFIP1/PDGFRB/PIP5K1C/ITGAL/CRKL/LIMK2/SLC9A1/ARPC5L/ARPC3/BRAF/ARHGEF7/RAF1/MAPK3/ROCK1/RRAS/MYL12A/MYL12B/LPAR4/BCAR1/PIK3R1/SSH3/ITGA2B/FGF23/MYLPF/ITGB7/PPP1R12A/ACTB/ACTN4/HRAS/PIK3R2/PIK3CA/GIT1/ARHGEF4/MYH14/CHRM3/PFN4/VAV2/F2R/ITGA8/CDC42/MYL10/CHRM4/ITGB5/PAK2/ROCK2/CXCR4/ITGAX/PIP4K2A/PTK2/PFN1/MAP2K1/FGF10/FGFR4/PPP1R12C/LPAR5/BAIAP2/PPP1CA/ITGA9/ITGAV/LPAR1/SOS2/MYLK3/PIP5K1A/CRK/ITGAE/SCIN/FGF6/GSN/ITGA7/PAK4/ITGA10/KRAS/PDGFD/FGF7/FGFR2/PPP1R12B/FGF4/ITGA4/FGF16/EGF/ITGB3/GNA12/DIAPH2/TMSB4X/MYH11/PIP5K1B/GNG12/PDGFB/MYLK/KNG1/PIP4K2B/PDGFC/ITGB1/TIAM1/SRC/FGF17/CFL2/PIP4K2C/INS/PPP1CC/MYL9/PIKFYVE/SSH2/TMSB4Y/SSH1/CHRM5/CHRM1/FGF22/ITGAD/FGF2/MOS/PPP1CB/ABI2/PDGFA/ACTR2/INSRR/FGF19/APC/FGFR1/MYL7/WASF2/NRAS/NCKAP1/ITGB8/FGF20/PIK3R3/FN1/DOCK1/RDX/PAK3/FGD1/PFN2/MRAS/MYL5/F2/FGF9/MYH10/ITGA3/BDKRB2/PDGFRA/CXCL12/BDKRB1/PAK6/WASF1/RRAS2	196
KEGG	hsa04070	Phosphatidylinositol signaling system	92/6408	97/8135	9.16e-06	5.773e-05	2.22e-05	PIK3C3/PLCD1/INPPL1/PLCB2/PIK3CB/ITPKC/MTMR14/IP6K2/PRKCB/IPPK/ITPKB/ITPK1/CALML6/DGKD/MTMR3/INPP5D/PIK3C2G/PIK3CD/PIP5K1C/INPP5E/PTEN/SACM1L/IP6K1/ITPR3/PLCB4/PI4KA/INPP5A/PI4K2A/IMPA2/PLCG2/PIK3R1/CALM2/CDIPT/MTMR6/PI4KB/PIK3R2/PIK3CA/ITPR2/CDS2/CALM1/PLCB3/DGKQ/MTMR1/DGKZ/MTMR4/INPP5B/PIP4K2A/PI4K2B/MTM1/IMPA1/PLCD3/PIP5K1A/PPIP5K2/PPIP5K1/INPP4B/PLCZ1/CALML4/INPP4A/DGKA/CALML5/ITPR1/DGKE/CDS1/PLCG1/IPMK/ITPKA/SYNJ1/PIP5K1B/INPP1/PLCD4/CALM3/PIP4K2B/CALML3/MTMR2/DGKI/PRKCG/PIP4K2C/DGKG/PIKFYVE/PIK3C2A/SYNJ2/PLCB1/IP6K3/PRKCA/PIK3R3/PLCE1/INPP5F/OCRL/MTMR7/MTMR8/PIK3C2B/DGKH	92
KEGG	hsa05130	Pathogenic Escherichia coli infection	178/6408	197/8135	1.016e-05	6.284e-05	2.416e-05	CLDN8/PTPN6/PAK1/CYTH1/ARHGEF2/ACTG1/TUBA1A/CASP9/TUBA1C/RAC1/GNA13/MYH9/MAPK14/SLC9A3R1/RHOA/MYO1F/ARPC4/NFKBIB/ARPC5/NCK2/NCKAP1L/ARHGEF1/MYD88/RAB1A/RIPK1/ARPC1A/IKBKG/GAPDH/CLDN1/LPAR2/ARPC1B/FCGR2A/ACTR3B/CYFIP2/ARPC2/IRAK1/CLDN3/MYO5B/TNFRSF1A/MAPK1/TUBAL3/CASP4/ACTR3/EZR/TMBIM6/SEC24C/WASL/TRADD/CYFIP1/CYTH4/SEC24B/ARF1/WIPF1/FADD/HCLS1/TUBA3D/TUBA3E/TUBA4A/MAPK9/ARPC5L/ARPC3/TUBA3C/TUBB1/FAS/MAPK3/ROCK1/FYN/CASP3/WIPF3/LPAR4/CLDN5/CASP8/ARHGEF11/IL1B/IRAK4/TRAF6/MAPK11/PYCARD/TUBA1B/TRAF2/TMED10/TIRAP/BAK1/NFKBIA/BAX/ACTB/TNFRSF10B/MAPK13/IKBKB/CLDN15/TLR5/TAB2/MYH14/TNF/MAPK12/CASP1/F2R/NCK1/ARF6/CDC42/NAIP/TNFSF10/MYO1E/JUN/PAK2/MYO1C/ROCK2/MAP3K7/CLDN19/RELA/LPAR5/TAB1/BAIAP2/TAB3/MYO1A/ABI1/CLDN9/CLDN2/NLRP3/LPAR1/CYTH3/NFKB1/SEC24D/ABL1/BAIAP2L1/CLDN6/TUBA8/CLDN23/CYCS/MYO1D/TUBB6/FOS/TNFRSF10A/MAPK8/WIPF2/GNA12/MYH11/CLDN4/MYO1G/WASF3/CYTH2/ITGB1/SRC/PTPN11/CASP7/CTTN/TUBB/IL18/CLDN11/CLDN7/MYO10/MYO5A/ACTR2/MYO6/WASF2/TUBB3/NCKAP1/CHUK/CLDN16/FASLG/NLRP4/ABCF2/SEC24A/PAK3/MAPK10/IL1R1/MYO5C/TLR4/RPS3/NCL/F2/MYO1H/MYH10/IL6/MYO1B/CLDN17/WASF1/CLDN14	178
KEGG	hsa05031	Amphetamine addiction	67/6408	69/8135	1.266e-05	7.688e-05	2.956e-05	GRIA2/CAMK2G/ATF4/PRKACA/HDAC1/PPP3R2/CREB3/PRKCB/CALML6/CACNA1C/GRIN2B/GNAS/ATF6B/PPP3CB/CALM2/CREB5/HDAC2/CALM1/JUN/GRIA3/DRD1/STX1A/CAMK2B/PPP1CA/PPP3CA/GRIN2C/CALML4/MAOA/ATF2/CALML5/GRIN1/CREB3L4/CREB3L2/FOS/PRKACB/SIRT1/CREB1/CALM3/GRIN2D/PRKACG/CALML3/CAMK2D/PRKCG/PPP1CC/PPP3CC/CACNA1D/CAMK2A/GRIA4/SLC18A2/ARC/PPP1CB/TH/GRIN3B/PRKCA/FOSB/GRIN2A/PPP3R1/SLC18A1/MAOB/GRIA1/GRIN3A/SLC6A3/CAMK4/CREB3L1/PDYN/PPP1R1B/DDC	67
KEGG	hsa04921	Oxytocin signaling pathway	141/6408	154/8135	1.456e-05	8.682e-05	3.338e-05	RYR3/CACNB3/ACTG1/CAMK2G/PLCB2/PRKACA/RHOA/CACNB1/GNAQ/NPPA/PPP3R2/MAP2K5/PRKCB/PLA2G4D/EEF2/CALML6/KCNJ6/CCND1/MAP2K2/PIK3R5/CACNA1C/GNAI1/GNAI3/NFATC1/MYLK2/MAPK1/MYL6B/PLA2G4C/GNAS/PRKAB1/ELK1/MYL6/NPR1/ADCY8/PPP3CB/ITPR3/PLCB4/NOS3/RAF1/MAPK3/TRPM2/ROCK1/RGS2/OXTR/CDKN1A/CACNG1/CALM2/ADCY6/PPP1R12A/ACTB/CACNA2D1/HRAS/JMJD7-PLA2G4B/PLA2G4B/PRKAG1/CAMKK2/CACNG8/GUCY1A2/RCAN1/ITPR2/ADCY4/CACNA2D4/PRKAG2/KCNJ12/CALM1/MAPK7/GNAI2/PLCB3/JUN/PRKAA1/KCNJ2/ROCK2/ADCY7/KCNJ5/MAP2K1/CAMK2B/KCNJ4/PPP1R12C/PPP1CA/PLA2G4F/GNAO1/CACNA2D2/MYLK3/CD38/PPP3CA/CAMK1D/CALML4/NFATC2/EEF2K/CALML5/CACNA1F/ITPR1/MEF2C/KRAS/PTGS2/NPR2/PPP1R12B/FOS/PRKACB/RYR1/CACNA1S/ADCY9/ADCY3/MYLK/CALM3/PRKACG/SRC/CALML3/CAMK2D/PIK3CG/PRKCG/CACNB2/PPP1CC/MYL9/PIK3R6/PPP3CC/CACNA1D/CAMK2A/CACNG4/KCNJ3/CACNG3/PPP1CB/NFATC4/PLCB1/PRKCA/NRAS/CAMK1G/PLA2G4A/NFATC3/PPP3R1/CAMK1/ADCY1/PRKAG3/RYR2/PRKAA2/CAMK4/OXT/ADCY2/CACNG5/PRKAB2/CACNG2	141
KEGG	hsa04066	HIF-1 signaling pathway	102/6408	109/8135	1.859e-05	0.0001089	4.189e-05	ALDOB/LDHAL6B/AKT2/IGF1/PGK1/CAMK2G/IFNGR2/PIK3CB/NPPA/EGLN2/PRKCB/LDHAL6A/RPS6KB2/MAP2K2/LTBR/GAPDH/TIMP1/ENO1/ANGPT2/PIK3CD/HK3/PDHA2/MAPK1/ENO3/MTOR/AKT1/EP300/AKT3/RPS6/IL6R/PGK2/NOS3/MAPK3/EGLN1/PFKP/PLCG2/PIK3R1/CDKN1A/EIF4E2/ALDOA/PDK1/IFNGR1/PDHB/EIF4EBP1/PIK3R2/PIK3CA/HK1/LDHA/PDHA1/MKNK1/EGLN3/CDKN1B/PFKFB3/HKDC1/ALDOC/ENO2/RELA/MAP2K1/CAMK2B/TFRC/VEGFA/NFKB1/IGF1R/TF/CYBB/FLT1/MKNK2/PFKM/HIF1A/PFKL/EDN1/RBX1/LDHB/SLC2A1/PLCG1/EGF/SERPINE1/EIF4E/INSR/HK2/CAMK2D/CUL2/PRKCG/INS/STAT3/RPS6KB1/CAMK2A/EPO/ANGPT4/LDHC/ARNT/PRKCA/BCL2/PIK3R3/CREBBP/IFNG/TLR4/VHL/HMOX1/IL6/ANGPT1/TEK	102
KEGG	hsa04720	Long-term potentiation	65/6408	67/8135	1.937e-05	0.0001115	4.288e-05	GRIA2/CAMK2G/PLCB2/ATF4/PRKACA/GNAQ/PPP3R2/PRKCB/CALML6/MAP2K2/CACNA1C/ARAF/RPS6KA1/MAPK1/GRIN2B/EP300/RPS6KA3/ADCY8/PPP3CB/ITPR3/PLCB4/BRAF/RAF1/MAPK3/CALM2/HRAS/RAP1A/ITPR2/CALM1/PLCB3/PPP1R1A/MAP2K1/CAMK2B/PPP1CA/RPS6KA2/PPP3CA/RAP1B/GRIN2C/CALML4/CALML5/ITPR1/KRAS/GRIN1/PRKACB/CALM3/GRIN2D/PRKACG/CALML3/CAMK2D/PRKCG/PPP1CC/PPP3CC/CAMK2A/PPP1CB/PLCB1/PRKCA/NRAS/RAPGEF3/RPS6KA6/CREBBP/GRIN2A/PPP3R1/GRIA1/ADCY1/CAMK4	65
KEGG	hsa05133	Pertussis	73/6408	76/8135	2.002e-05	0.0001133	4.358e-05	IL12A/SFTPA1/IRF1/ITGB2/CFL1/MAPK14/ITGA5/RHOA/C1R/MYD88/CALML6/GNAI1/GNAI3/ITGAM/IRAK1/MAPK1/C4BPB/MAPK9/TICAM1/MAPK3/CASP3/IL10/NOD1/C2/CALM2/IL1B/CD14/IRAK4/TRAF6/MAPK11/PYCARD/TIRAP/IRF3/MAPK13/IL23A/TNF/LY96/MAPK12/CASP1/CALM1/GNAI2/JUN/RELA/C1QB/C3/NLRP3/NFKB1/CALML4/C5/C1QA/CALML5/FOS/TICAM2/MAPK8/SERPING1/IL12B/CALM3/ITGB1/CALML3/CFL2/CASP7/C1S/C4A/C4B/C1QC/C4BPA/CXCL6/MAPK10/TLR4/SFTPA2/CXCL5/IL6/IL1A	73
KEGG	hsa05205	Proteoglycans in cancer	184/6408	205/8135	2.076e-05	0.0001156	4.444e-05	FZD10/WNT2/PTPN6/PAK1/WNT9B/AKT2/IGF1/HSPB2/TFAP4/ACTG1/GRB2/CAMK2G/IQGAP1/MDM2/PRKACA/RAC1/MAPK14/FZD2/PIK3CB/ITGA5/RHOA/WNT3/PXN/ARHGEF1/ANK3/WNT7B/PRKCB/VAV1/MSN/SOS1/RPS6KB2/CD63/ITGA2/CCND1/MAP2K2/WNT7A/WNT8B/TGFB1/TGFB2/ARAF/PIK3CD/SMAD2/HSPG2/MAPK1/FLNC/EZR/MTOR/GPC1/AKT1/AKT3/ELK1/WNT16/RPS6/HCLS1/SLC9A1/ITPR3/BRAF/RAF1/FAS/MAPK3/ROCK1/CASP3/RRAS/PLCG2/PIK3R1/CDKN1A/VTN/MAPK11/THBS1/TWIST2/WNT10B/PPP1R12A/ACTB/MAPK13/FZD1/HRAS/PIK3R2/PIK3CA/TNF/ITPR2/MAPK12/WNT1/VAV2/CDC42/ITGB5/PLAUR/ROCK2/MIR21/PTK2/NUDT16L1/MAP2K1/CAMK2B/SHH/PPP1R12C/PPP1CA/HGF/VEGFA/ITGAV/IGF1R/SOS2/WNT8A/PDCD4/HIF1A/TLR2/MMP9/FZD9/ITPR1/KRAS/PLAU/FRS2/PPP1R12B/FLNB/PRKACB/PLCG1/SDC2/DDX5/SDC4/ITGB3/EIF4B/CD44/IL12B/MMP2/CBL/FLNA/WNT4/PRKACG/ITGB1/TIAM1/SRC/CAMK2D/ANK2/PTPN11/PRKCG/HPSE/PPP1CC/STAT3/KDR/CTTN/RPS6KB1/TP53/CAMK2A/COL1A1/PTCH1/SDC1/WNT5B/ESR1/FGF2/TIMP3/ERBB3/PPP1CB/CTNNB1/TWIST1/ERBB4/HPSE2/ANK1/FGFR1/FZD6/PRKCA/NRAS/FASLG/CAV2/PIK3R3/DCN/FN1/HBEGF/GAB1/PLCE1/RDX/PDPK1/IGF2/WNT5A/NANOG/FZD8/TLR4/MIR10B/MRAS/FZD3/MET/GPC3/HOXD10/FZD7/MYC/CAV3/RRAS2	184
KEGG	hsa04015	Rap1 signaling pathway	188/6408	210/8135	2.523e-05	0.0001381	5.311e-05	FGF5/RASSF5/FGF1/PARD6A/EFNA3/ADORA2A/ITGB2/AKT2/IGF1/TLN1/FARP2/ACTG1/PLCB2/RAC1/MAPK14/PIK3CB/RHOA/GNAQ/RGS14/SIPA1L1/RAC2/PRKCB/VAV1/FGF3/CALML6/MAP2K2/APBB1IP/FGF18/GNAI1/RAPGEF5/GNAI3/ITGAM/LPAR2/VASP/ANGPT2/PIK3CD/MAPK1/ADORA2B/GRIN2B/AKT1/GNAS/LCP2/AKT3/PDGFRB/F2RL3/EVL/ITGAL/ARAP3/PRKD2/ADCY8/CRKL/SIPA1/PLCB4/EFNA4/BRAF/RAF1/KIT/MAPK3/RRAS/LPAR4/BCAR1/PIK3R1/ITGA2B/CALM2/ADCY6/CSF1R/MAPK11/FGF23/THBS1/VEGFC/MAGI1/ACTB/MAPK13/RALA/FPR1/HRAS/PIK3R2/PIK3CA/RAP1A/MAPK12/RALGDS/ADCY4/PFN4/VAV2/F2R/CALM1/GNAI2/FLT4/CDC42/PLCB3/TLN2/ADCY7/PRKCZ/MAP2K6/LAT/PFN1/MAP2K1/FGF10/FGFR4/RASGRP2/LPAR5/HGF/VEGFA/GNAO1/LPAR1/IGF1R/PARD3/VEGFB/FLT1/RAP1B/CRK/RALB/PRKD1/FGF6/CALML4/CALML5/KRAS/PDGFD/FGF7/GRIN1/FGFR2/FGF4/PLCG1/FGF16/EGF/ITGB3/ADCY9/PARD6G/PDGFB/RAPGEF1/ADCY3/CALM3/SIPA1L2/DOCK4/PGF/PDGFC/ITGB1/INSR/TIAM1/SRC/CALML3/FGF17/PRKCG/INS/DRD2/KDR/SKAP1/RAPGEF4/FGF22/EFNA5/KRIT1/FGF2/ANGPT4/MAGI3/PDGFA/CTNNB1/FGF19/RAP1GAP/PLCB1/EFNA2/FGFR1/MAP2K3/RASGRP3/PRKCA/NRAS/FGF20/PIK3R3/RAPGEF6/RAPGEF3/PLCE1/GRIN2A/EFNA1/PFN2/CTNND1/MRAS/ADCY1/FGF9/PARD6B/CSF1/MET/RAPGEF2/PDGFRA/SIPA1L3/ANGPT1/ADCY2/KITLG/TEK/NGF	188
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	99/6408	106/8135	3.163e-05	0.0001678	6.45e-05	CYP24A1/GCM2/PTH/SLC34A2/MMP14/PLCB2/ATF4/PRKACA/GNA13/SLC9A3R1/RHOA/GNAQ/LRP5/ARHGEF1/CREB3/PRKCB/ARRB1/GNA11/GNAI1/GNAI3/NACA/CASR/PDE4B/ARAF/SOST/RXRA/MAPK1/ARRB2/GNAS/PLD2/ATF6B/ADCY8/ITPR3/PLCB4/BRAF/RAF1/MAPK3/VDR/BGLAP/CDKN1A/ARHGEF11/MEF2D/PDE4D/ADCY6/MMP24/FGF23/CREB5/PLD1/JUND/MMP25/ITPR2/PTHLH/ADCY4/MEF2A/GNAI2/PLCB3/RXRB/ADCY7/MMP17/MAP2K1/TRPV5/CYP27B1/ATF2/PTH1R/ITPR1/MEF2C/CREB3L4/CREB3L2/FOS/PRKACB/GNA12/GATA3/MMP15/CREB1/ADCY9/MAFB/AKAP13/ADCY3/PRKACG/PRKCG/PDE4C/GCM1/SLC34A1/PLCB1/FGFR1/RUNX2/LRP6/MMP16/PRKCA/BCL2/MMP13/HBEGF/NR4A2/PDE4A/ADCY1/KL/RXRG/ADCY2/CREB3L1	99
KEGG	hsa04024	cAMP signaling pathway	197/6408	221/8135	3.164e-05	0.0001678	6.45e-05	LHCGR/CNGA3/CNGB3/FSHR/GRIA2/HTR1D/VIP/GCG/NPY1R/CHRM2/CNGA1/FXYD1/DRD5/PAK1/BAD/ADORA2A/AKT2/PPARA/HHIP/CAMK2G/PRKACA/RAC1/CRHR1/PIK3CB/RHOA/NPPA/CREB3/RAC2/VAV1/ATP2A2/CALML6/MAP2K2/CRH/CACNA1C/GNAI1/GLI3/GNAI3/PDE4B/NFATC1/PIK3CD/CFTR/MAPK1/GRIN2B/AKT1/EP300/GNAS/ATP1B3/PLD2/AKT3/MC2R/NPR1/ARAP3/ADCY8/MAPK9/SLC9A1/BRAF/ATP2A3/RAF1/MAPK3/ROCK1/RRAS/OXTR/HTR6/PIK3R1/CALM2/GLP1R/PDE4D/ADCY6/ACOX1/ATP2B2/CREB5/HCN2/GHRL/PLD1/PPP1R12A/NFKBIA/ATP2B1/AMH/PIK3R2/PTGER2/PLN/GPHA2/PIK3CA/RAP1A/CNGB1/ADCY4/VAV2/F2R/CALM1/CGA/GNAI2/JUN/SSTR5/GABBR1/GRIA3/ROCK2/DRD1/ADCY7/RELA/MAP2K1/ORAI1/CAMK2B/PPP1CA/NFKB1/RAP1B/GRIN2C/CALML4/ABCC4/PDE3A/VIPR2/ATP2B3/ADCYAP1R1/EDN1/CALML5/CACNA1F/ATP2B4/POMC/GRIN1/CREB3L4/CREB3L2/ADORA1/FOS/ACOX3/PRKACB/SST/MAPK8/CNGA4/CACNA1S/FXYD2/CREB1/ADCY9/ATP1A1/ADCY3/CALM3/GRIN2D/HTR1F/PRKACG/TIAM1/CALML3/ADRB2/CAMK2D/PDE10A/GABBR2/SOX9/GPHB5/PPP1CC/MYL9/SSTR1/DRD2/CACNA1D/CAMK2A/GRIA4/RAPGEF4/PTCH1/PDE4C/CHRM1/GHSR/PPP1CB/BDNF/GLI1/HTR1A/HTR1B/EDNRA/GRIN3B/FFAR2/PDE3B/HCN4/CRHR2/HTR1E/PIK3R3/RAPGEF3/CREBBP/PLCE1/GRIN2A/ADRB1/MAPK10/TSHB/GRIA1/PDE4A/ADCY1/GRIN3A/FSHB/PTGER3/RYR2/EDN2/CAMK4/ATP1A4/ADCYAP1/OXT/ADCY2/CREB3L1/ATP1A3/TSHR/PPP1R1B/LHB/ATP1A2/RRAS2	197
KEGG	hsa05215	Prostate cancer	91/6408	97/8135	4.025e-05	0.00021	8.076e-05	PLAT/MMP3/BAD/AKT2/IGF1/GRB2/CASP9/E2F1/MDM2/ATF4/PIK3CB/CREB3/SOS1/CCND1/MAP2K2/IKBKG/HSP90B1/ARAF/PIK3CD/MAPK1/MTOR/AKT1/EP300/AKT3/PDGFRB/PTEN/BRAF/RAF1/MAPK3/PIK3R1/CDKN1A/CREB5/NFKBIA/HRAS/PIK3R2/IKBKB/PIK3CA/TCF7/CDKN1B/RELA/MAP2K1/HSP90AA1/NFKB1/IGF1R/IL1R2/SOS2/SPINT1/E2F3/TCF7L2/MMP9/FOXO1/CDK2/KRAS/PDGFD/FGFR2/PLAU/CREB3L4/TMPRSS2/ETV5/CREB3L2/EGF/CREB1/PDGFB/CCNE2/KLK3/SRD5A2/PDGFC/GSTP1/HSP90AB1/CCNE1/INS/TGFA/TP53/RB1/ZEB1/ERG/PDGFA/INSRR/CTNNB1/FGFR1/NRAS/BCL2/CHUK/AR/PIK3R3/E2F2/CREBBP/PDPK1/PDGFRA/CREB3L1/GSK3B	91
KEGG	hsa04620	Toll-like receptor signaling pathway	97/6408	104/8135	4.493e-05	0.0002259	8.686e-05	IL12A/IFNA2/IFNB1/IFNA1/IFNA13/AKT2/RAC1/MAPK14/PIK3CB/CD40/MYD88/RIPK1/MAP2K2/IKBKG/TLR1/TBK1/PIK3CD/IRAK1/IFNAR1/MAPK1/TLR9/AKT1/AKT3/FADD/MAPK9/TICAM1/MAPK3/TOLLIP/PIK3R1/CASP8/IL1B/CD14/IRAK4/TRAF6/MAPK11/TIRAP/IRF3/NFKBIA/MAPK13/PIK3R2/IKBKB/PIK3CA/TLR5/TAB2/TNF/LY96/MAPK12/IRF7/JUN/MAP2K4/STAT1/TLR8/MAP3K7/MAP2K6/RELA/MAP2K1/TAB1/IFNA8/NFKB1/TRAF3/IKBKE/MAP2K7/TLR2/CD86/TLR7/FOS/TICAM2/MAPK8/CTSK/IL12B/IFNAR2/TLR6/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/CCL4/CCL5/CD80/MAP3K8/CXCL11/MAP2K3/IRF5/CHUK/PIK3R3/MAPK10/TLR4/IFNA17/CCL3/CCL3L1/CCL3L3/IL6/SPP1	97
KEGG	hsa04660	T cell receptor signaling pathway	97/6408	104/8135	4.493e-05	0.0002259	8.686e-05	IL2/PTPN6/PAK1/AKT2/GRB2/MAPK14/PIK3CB/RHOA/NFKBIB/NCK2/PPP3R2/VAV1/SOS1/MAP2K2/IKBKG/PDCD1/NFKBIE/NFATC1/PIK3CD/MAPK1/AKT1/LCP2/AKT3/CARD11/CD4/PPP3CB/MAPK9/RAF1/MAPK3/FYN/IL10/PIK3R1/MAPK11/NFKBIA/MAPK13/HRAS/PIK3R2/IKBKB/PIK3CA/TNF/MAPK12/VAV2/NCK1/CDC42/JUN/MALT1/PTPRC/PAK2/MAP3K7/RELA/CD3D/LAT/MAP2K1/TEC/CBLB/CSF2/DLG1/NFKB1/SOS2/PPP3CA/PRKCQ/RASGRP1/MAP2K7/LCK/NFATC2/ICOS/ZAP70/PAK4/KRAS/IL4/FOS/PLCG1/MAPK8/CD40LG/CD3G/BCL10/CTLA4/MAP3K14/CDK4/PPP3CC/MAP3K8/ITK/CD28/NRAS/CD8B/CHUK/PIK3R3/IFNG/PDPK1/PAK3/NFATC3/GRAP2/PPP3R1/MAPK10/CD3E/PAK6/GSK3B	97
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	408/6408	476/8135	4.532e-05	0.0002259	8.686e-05	ATXN3L/FZD10/GRIA2/SLC25A31/RYR3/COX6A2/COX8C/WNT2/COX7B2/NOX1/GPX5/COX4I2/PSMD6/PIK3C3/NDUFS7/WNT9B/UQCRB/BAD/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/PSMA6/NDUFS2/ACTR10/CAMK2G/TUBA1A/PSMA3/CASP9/TUBA1C/UBA1/PSMA7/PLCB2/ATF4/RAC1/MAPK14/FZD2/PARK7/GNAQ/WNT3/HTT/LRP5/HTRA2/PIK3R4/PPP3R2/PSMB1/PSMC1/PSMC4/TNFRSF1B/COX6B1/WNT7B/DVL1/PRKCB/WIPI2/COX8A/UBE2G1/HSPA5/CSNK1E/ATP2A2/UBE2J2/UBC/RAB1A/CALML6/NDUFB10/ACTR1A/MAP2K2/PSMD1/WNT7A/KLC1/NDUFA4/DNAL4/MAP1LC3B/NDUFV2/CACNA1C/TOMM40L/SLC25A4/WNT8B/APP/CSNK2B/UQCRFS1/FRAT1/DVL2/VDAC2/TOMM40/TBK1/NDUFB4/ARAF/NDUFA10/NDUFB2/UQCR10/PSMA2/PINK1/ATXN2L/APC2/PSMD12/PSMB5/TNFRSF1A/MAPK1/NDUFB11/TUBAL3/GRIN2B/GPR37/MTOR/ZFYVE1/RAB5A/UQCRH/PSMD2/DAXX/PSMD13/TARDBP/COX7B/PSEN1/WNT16/SDHA/COX7A2/NDUFB6/DNAH1/PSMD7/NDUFB8/SMCR8/PPIF/FADD/PPP3CB/SQSTM1/UQCRC2/RB1CC1/TUBA3D/TUBA3E/TUBA4A/MAPK9/ITPR3/PLCB4/BRAF/TUBA3C/ATP2A3/RAF1/TUBB1/FAS/MAPK3/NDUFA7/CASP3/SPG11/DNAH7/FIG4/EIF2S1/CSNK1A1/PSMD4/UBA7/NDUFA2/HSD17B10/COX6C/UBE2J1/DCTN6/NDUFC2/VCP/ADRM1/UBE2L3/CASP8/VDAC3/MAP1LC3A/MFN2/XBP1/CALM2/NDUFA6/PRNP/PSMC6/IL1B/PSMD9/PSMC2/DCTN1/MAPK11/SOD1/TUBA1B/ALS2/TRAF2/AMBRA1/C9orf72/DCTN2/WNT10B/BAK1/ACTR1B/NDUFS8/NDUFB1/BAX/MAPK13/NDUFA12/NDUFS3/BID/FZD1/PSMA1/CAPN2/HRAS/NEFL/BCL2L1/PSMC5/KIF5C/COX4I1/CYC1/DLG4/PSMD11/CAT/MAP3K5/DKK1/TNF/UBA52/DDIT3/UQCR11/ITPR2/MAPK12/CHRM3/NDUFA9/WNT1/NDUFS4/ATF6/SLC25A5/DNAH2/HAP1/CALM1/SDHB/BECN1/COX6B2/CHMP2B/ATG2B/PLCB3/NDUFA11/KIF5B/DNAH9/CDK5/CSNK2A2/PPID/ATXN2/DCTN3/NDUFV1/MAP3K10/NDUFB5/NDUFAB1/GRIA3/EIF2AK3/SDHC/STX1A/PSMB3/MAP2K6/RELA/CSNK2A1/ATXN1/UBE2L6/MAP2K1/DNAH17/ULK1/ATG2A/CAMK2B/COX5A/PSEN2/NDUFS6/MAP1LC3C/NDUFA3/NDUFB9/DCTN5/DERL1/COX6A1/PSMD8/SIGMAR1/NFKB1/PSMA4/PSMB7/PSMD14/CYBB/ULK2/WNT8A/PPP3CA/NDUFS5/RAB39B/COX7C/APAF1/ATXN1L/ATXN3/MAP2K7/GRIN2C/WIPI1/CALML4/KLC4/NEFH/DNAI1/FZD9/WDR41/TUBA8/CALML5/CYCS/CACNA1F/ITPR1/CCS/KRAS/TRAP1/PTGS2/DNAI2/GRIN1/NDUFA8/TUBB6/PSMA5/DCTN4/NEFM/PLCG1/MAPK8/VAPB/PSMB6/DKK2/NDUFA13/RYR1/CACNA1S/LRRK2/CHRNA7/AGER/COX7A2L/NDUFA5/HIP1/DNAH3/CASP12/WNT4/PSMD3/PSMB2/ERN1/CALM3/PSMA8/GPX7/GRIN2D/PSMC3/NOX4/GPX2/KLC3/CALML3/CAMK2D/PRKCG/NDUFV3/DNAH10/CASP7/SDHD/PPP3CC/CACNA1D/CAMK2A/FRAT2/TUBB/GRIA4/CHRM5/CACNA1B/MAP1LC3B2/CAPN1/CHRM1/DVL3/WNT5B/DNAH8/MFN1/OPTN/BDNF/NRBF2/CTNNB1/UBE2G2/PLCB1/APC/AXIN1/LRP6/TUBB3/FZD6/MAP2K3/PRKCA/NRAS/BCL2/FASLG/TANK/MAPT/GRIN2A/PPP3R1/MAPK10/WNT5A/RPS27A/UQCRC1/FZD8/RAB8A/GPX1/GRIA1/NDUFB7/FZD3/SLC25A6/DNAL1/CSF1/SNCAIP/DKK4/IFT57/SLC6A3/RYR2/KLC2/CDK5R1/VDAC1/FUS/IL6/KIF5A/DNAH6/FZD7/DNALI1/PDYN/NDUFA4L2/UBB/GSK3B/IL1A/UCHL1/GPX8	408
KEGG	hsa04213	Longevity regulating pathway - multiple species	60/6408	62/8135	5.563e-05	0.0002725	0.0001048	AKT2/IGF1/PRKACA/PIK3CB/HDAC1/RPTOR/RPS6KB2/ATG5/HSPA6/PIK3CD/MTOR/AKT1/AKT1S1/PRKAB1/AKT3/ADCY8/IRS2/PIK3R1/ADCY6/SOD1/HDAC2/HRAS/PIK3R2/PRKAG1/CAT/PIK3CA/HSPA8/HSPA1L/ADCY4/CLPB/PRKAG2/HSPA1A/PRKAA1/IRS1/ADCY7/IGF1R/EIF4EBP2/FOXO1/KRAS/SOD2/PRKACB/HSPA1B/IRS4/SIRT1/ADCY9/ADCY3/PRKACG/INSR/INS/RPS6KB1/NRAS/FOXO3/PIK3R3/CRYAB/ADCY1/PRKAG3/PRKAA2/ADCY2/PRKAB2/HSPA2	60
KEGG	hsa04145	Phagosome	138/6408	152/8135	5.63e-05	0.0002725	0.0001048	MBL2/CLEC4M/HLA-E/SFTPA1/ATP6V1H/PIK3C3/VAMP3/ITGB2/CD209/ACTG1/TUBA1A/TUBA1C/RAC1/ATP6V0D1/ITGA5/SEC61B/HLA-B/ATP6V0A1/HLA-C/C1R/TAP1/ATP6V0E1/ATP6AP1/STX12/MRC2/ITGA2/THBS4/DYNC1LI1/ATP6V1B2/LAMP2/ATP6V0B/NCF4/ATP6V1E2/ITGAM/FCGR2A/NCF1/NCF2/TUBAL3/CORO1A/RAB5A/ATP6V1E1/TUBA3D/TUBA3E/HLA-A/TUBA4A/DYNC1LI2/TUBA3C/ATP6V1D/TUBB1/TCIRG1/STX7/DYNC1H1/CD14/HGS/TUBA1B/THBS1/STX18/LAMP1/SEC61A2/ACTB/CTSS/MARCO/CLEC7A/THBS3/ATP6V1B1/ATP6V1F/HLA-G/CD36/DYNC1I2/ATP6V1C1/ITGB5/HLA-F/RAB5B/HLA-DMB/FCGR3B/TFRC/CYBA/FCGR2C/RAB7A/SEC61G/C3/ATP6V0E2/TAP2/ATP6V0A2/ITGAV/SFTPD/CYBB/ATP6V0C/FCGR1A/CANX/ATP6V1A/ATP6V0D2/TLR2/M6PR/TUBA8/COLEC11/RILP/RAB7B/TUBB6/HLA-DMA/SEC61A1/RAB5C/ITGB3/FCGR2B/FCAR/SCARB1/ATP6V1G3/TLR6/HLA-DRA/ITGB1/CALR/COMP/SEC22B/MPO/THBS2/PIKFYVE/HLA-DPA1/TUBB/HLA-DOA/PLA2R1/HLA-DQB1/TUBB3/FCGR3A/ATP6V1G2/TLR4/EEA1/HLA-DOB/DYNC2H1/HLA-DQA1/HLA-DQA2/SFTPA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/ATP6V0A4/DYNC1I1/COLEC12	138
KEGG	hsa04068	FoxO signaling pathway	120/6408	131/8135	6.085e-05	0.0002903	0.0001116	PCK1/CCNB3/USP7/BCL2L11/AKT2/FOXG1/IGF1/BCL6/GRB2/MDM2/GADD45B/MAPK14/FBXO32/PIK3CB/PLK3/CSNK1E/SOS1/GABARAP/CCND1/MAP2K2/TGFB1/FOXO6/TGFB2/ARAF/PIK3CD/MAPK1/AKT1/EP300/PRKAB1/SETD7/AKT3/ATG12/PTEN/S1PR4/SMAD4/MAPK9/BRAF/RAF1/FBXO25/MAPK3/IL10/IRS2/HOMER3/PIK3R1/STK11/CDKN1A/MAPK11/AGAP2/G6PC/SMAD3/MAPK13/HRAS/PIK3R2/IKBKB/CDKN2D/PRKAG1/CAT/PIK3CA/PCK2/MAPK12/GABARAPL1/GABARAPL2/PRKAG2/TNFSF10/PRKAA1/CDKN1B/IRS1/STK4/RBL2/MAP2K1/RAG1/ATM/IGF1R/SOS2/GADD45A/CDKN2B/BNIP3/TGFBR2/GADD45G/FOXO4/CCND2/FOXO1/G6PC2/CDK2/KRAS/SOD2/IRS4/MAPK8/EGF/CCNG2/SIRT1/G6PC3/SGK3/TGFBR1/PRMT1/INSR/INS/STAT3/SGK2/PLK4/SKP2/IL7R/NRAS/FOXO3/CHUK/FASLG/KLF2/PIK3R3/CREBBP/PDPK1/MAPK10/S1PR1/PRKAG3/CCNB2/PRKAA2/RAG2/SLC2A4/IL6/SGK1/PRKAB2	120
KEGG	hsa04920	Adipocytokine signaling pathway	66/6408	69/8135	8.171e-05	0.0003844	0.0001478	ADIPOQ/PCK1/ADIPOR2/AKT2/PPARA/NFKBIB/TNFRSF1B/ACSL3/IKBKG/CPT1C/NFKBIE/TNFRSF1A/RXRA/MTOR/AKT1/PRKAB1/TRADD/AKT3/MAPK9/IRS2/JAK2/STK11/ACSBG2/TRAF2/G6PC/NFKBIA/IKBKB/PRKAG1/CAMKK2/CPT1B/TNF/PCK2/PRKAG2/CD36/ACSL4/PRKAA1/IRS1/CPT1A/RXRB/RELA/NFKB1/PRKCQ/ACSL1/G6PC2/POMC/LEP/SLC2A1/IRS4/MAPK8/ACSL5/ACSBG1/G6PC3/SOCS3/PTPN11/STAT3/ADIPOR1/ACSL6/CHUK/ACACB/MAPK10/LEPR/PRKAG3/RXRG/PRKAA2/SLC2A4/PRKAB2	66
KEGG	hsa04926	Relaxin signaling pathway	118/6408	129/8135	8.329e-05	0.0003864	0.0001486	GNG13/AKT2/GNG5/GRB2/PLCB2/ATF4/PRKACA/MAPK14/PIK3CB/SHC1/GNB1/GNA15/GNG2/CREB3/RXFP2/ARRB1/GNG10/SOS1/RXFP3/MAP2K2/GNAI1/GNAI3/TGFB1/PIK3CD/SMAD2/MAPK1/SHC3/ARRB2/AKT1/GNAS/AKT3/ATF6B/GNGT2/ADCY8/MAPK9/PLCB4/NOS3/RAF1/MAPK3/GNB2/PIK3R1/ADCY6/MAPK11/CREB5/VEGFC/NFKBIA/MAPK13/GNB5/HRAS/PIK3R2/PIK3CA/MAPK12/ADCY4/GNAI2/PLCB3/JUN/MAP2K4/GNB3/ADCY7/GNG3/PRKCZ/RELA/MAP2K1/VEGFA/GNAO1/RXFP1/GNG7/NFKB1/VEGFB/GNG11/SOS2/INSL3/MAP2K7/TGFBR2/MMP9/ATF2/EDN1/KRAS/CREB3L4/CREB3L2/FOS/GNG8/PRKACB/MAPK8/ACTA2/COL4A3/CREB1/ADCY9/TGFBR1/GNB4/GNGT1/COL4A5/GNG12/MMP2/ADCY3/PRKACG/SRC/COL4A2/COL1A1/COL4A6/PLCB1/SHC2/PRKCA/NRAS/SHC4/MMP1/PIK3R3/MMP13/MAPK10/EDNRB/ADCY1/COL4A1/GNG4/RLN2/ADCY2/CREB3L1/RLN3/COL3A1	118
KEGG	hsa05140	Leishmaniasis	73/6408	77/8135	8.716e-05	0.0003988	0.0001533	IL12A/PTPN6/ITGB2/IFNGR2/MAPK14/NFKBIB/PRKCB/MYD88/NCF4/ITGAM/TGFB1/FCGR2A/TGFB2/NCF1/IRAK1/NCF2/MAPK1/ELK1/MAPK3/IL10/JAK2/IL1B/IRAK4/TRAF6/MAPK11/IFNGR1/EEF1A1/NFKBIA/MAPK13/TAB2/TNF/MAPK12/MARCKSL1/CR1/JUN/STAT1/MAP3K7/HLA-DMB/RELA/FCGR3B/CYBA/FCGR2C/TAB1/C3/EEF1A2/NFKB1/CYBB/FCGR1A/TLR2/PTGS2/IL4/FOS/ITGA4/HLA-DMA/IL12B/HLA-DRA/ITGB1/HLA-DPA1/CR1L/HLA-DOA/HLA-DQB1/FCGR3A/JAK1/IFNG/TLR4/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/IL1A	73
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	93/6408	100/8135	8.996e-05	0.0004061	0.0001561	NOX1/PLCD1/AKT2/DIAPH1/PLCB2/RAC1/MAPK14/PIK3CB/STAT5B/PRKCB/CCND1/STAT5A/TGFB1/TGFB2/NFATC1/PIK3CD/SMAD2/MAPK1/AKT1/AKT3/SMAD4/MAPK9/PLCB4/NOS3/MAPK3/CASP3/JAK2/PLCG2/PIK3R1/IL1B/F3/MAPK11/VEGFC/SMAD3/BAX/MAPK13/HRAS/PIK3R2/PIK3CA/TNF/MAPK12/ICAM1/CDC42/PLCB3/JUN/CDKN1B/STAT1/PRKCZ/RELA/AGTR1/PLCD3/VEGFA/NFKB1/VEGFB/PRKCD/CYBB/SELE/TGFBR2/EDN1/FOXO1/KRAS/PLCG1/MAPK8/SERPINE1/COL4A3/AGER/TGFBR1/COL4A5/MMP2/PLCD4/NOX4/COL4A2/STAT3/CDK4/COL1A1/COL4A6/PLCB1/PRKCA/NRAS/BCL2/PIK3R3/FN1/PLCE1/MAPK10/CCL2/VCAM1/COL4A1/THBD/PIM1/IL6/IL1A/PRKCE/COL3A1	93
KEGG	hsa04919	Thyroid hormone signaling pathway	111/6408	121/8135	9.831e-05	0.0004378	0.0001683	SLC16A2/DIO1/SLCO1C1/BAD/PLCD1/AKT2/NCOA3/ACTG1/CASP9/MDM2/PLCB2/PRKACA/PIK3CB/HDAC1/PRKCB/ATP2A2/THRB/CCND1/MAP2K2/NCOA1/PIK3CD/RXRA/MAPK1/NOTCH1/MTOR/TSC2/AKT1/EP300/ATP1B3/AKT3/HDAC3/MED12/SLC9A1/PLCB4/ATP2A3/RAF1/MAPK3/PFKP/RHEB/PLCG2/PIK3R1/ACTB/HDAC2/HRAS/PIK3R2/PLN/NCOR1/PIK3CA/RCAN1/MED24/PLCB3/STAT1/RXRB/MED13/MAP2K1/MYH6/PLCD3/ITGAV/MED16/MED12L/PFKM/HIF1A/PFKFB2/PLCZ1/PFKL/SIN3A/KAT2B/FOXO1/KRAS/MED27/PRKACB/SLC2A1/PLCG1/MED4/ITGB3/FXYD2/THRA/ATP1A1/MED14/PLCD4/WNT4/PRKACG/SRC/MYH7/MED17/MED13L/KAT2A/PRKCG/DIO3/MED1/TP53/NCOA2/ESR1/CTNNB1/PLCB1/PRKCA/NRAS/NOTCH2/PIK3R3/CREBBP/PLCE1/PDPK1/RXRG/ATP1A4/ATP1A3/MYC/MED30/ATP1A2/GSK3B/SLC16A10/TBC1D4	111
KEGG	hsa04370	VEGF signaling pathway	57/6408	59/8135	0.0001042	0.0004573	0.0001758	BAD/AKT2/CASP9/RAC1/MAPK14/PIK3CB/PPP3R2/PXN/RAC2/PRKCB/PLA2G4D/MAP2K2/PIK3CD/MAPK1/AKT1/PLA2G4C/AKT3/PPP3CB/NOS3/RAF1/MAPK3/PLCG2/PIK3R1/MAPK11/MAPK13/HRAS/PIK3R2/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/MAPK12/MAPKAPK2/CDC42/PTK2/MAP2K1/VEGFA/PLA2G4F/MAPKAPK3/PPP3CA/HSPB1/NFATC2/KRAS/PTGS2/PLCG1/SH2D2A/SRC/PRKCG/KDR/PPP3CC/SPHK2/SHC2/PRKCA/NRAS/SPHK1/PIK3R3/PLA2G4A/PPP3R1	57
KEGG	hsa05212	Pancreatic cancer	72/6408	76/8135	0.0001054	0.0004573	0.0001758	BAD/AKT2/CASP9/E2F1/RAC1/GADD45B/PIK3CB/RAC2/RPS6KB2/CCND1/IKBKG/ARHGEF6/TGFB1/TGFB2/ARAF/PIK3CD/SMAD2/MAPK1/MTOR/AKT1/PLD2/AKT3/SMAD4/MAPK9/BRAF/RAF1/MAPK3/PIK3R1/CDKN1A/DDB2/BAK1/PLD1/SMAD3/BAX/RALA/PIK3R2/BCL2L1/IKBKB/PIK3CA/RALGDS/POLK/CDC42/RALBP1/STAT1/RELA/MAP2K1/VEGFA/CDKN2A/NFKB1/E2F3/RALB/GADD45A/TGFBR2/GADD45G/KRAS/MAPK8/EGF/TGFBR1/TGFA/STAT3/CDK4/RPS6KB1/TP53/RB1/RAD51/CHUK/CDK6/JAK1/PIK3R3/E2F2/MAPK10/BRCA2	72
KEGG	hsa04146	Peroxisome	77/6408	82/8135	0.00015	0.0006276	0.0002413	HAO1/DAO/ACAA1/PEX10/GSTK1/PAOX/MPV17L2/HMGCL/ABCD1/ACSL3/ECH1/PEX5L/GNPAT/MPV17/MPV17L/MLYCD/PEX19/AMACR/PEX11B/ACOX1/FAR1/SOD1/PEX12/CAT/PMVK/CRAT/ACSL4/HSD17B4/HACL1/DHRS4/PEX13/ABCD4/XDH/PEX26/PEX11G/PRDX1/SLC27A2/ACSL1/DECR2/PHYH/CROT/DDO/PECR/SOD2/ACOX3/PEX6/ACSL5/IDH2/PEX11A/PEX16/IDH1/AGPS/SLC25A17/FAR2/MVK/PRDX5/ABCD3/PEX1/PXMP2/ACOT8/ABCD2/ACSL6/PEX5/AGXT/PIPOX/PEX14/PEX2/PXMP4/HAO2/NUDT19/NUDT7/ACOX2/PEX3/SCP2/EPHX2/BAAT/EHHADH	77
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	90/6408	97/8135	0.0001503	0.0006276	0.0002413	PAK1/AKT2/INPPL1/CFL1/RAC1/PIK3CB/ARPC4/ARPC5/SYK/RAC2/PRKCB/VAV1/PLA2G4D/RPS6KB2/ARPC1A/WAS/INPP5D/VASP/ARPC1B/FCGR2A/ACTR3B/ARPC2/NCF1/PIK3CD/MAPK1/LIMK1/ACTR3/AKT1/PLA2G4C/PLD2/AKT3/PIP5K1C/CRKL/LIMK2/ARPC5L/ARPC3/RAF1/MAPK3/PLCG2/PIK3R1/ASAP1/PLA2G6/PLD1/PIK3R2/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/VAV2/HCK/MARCKSL1/ARF6/CDC42/LYN/GAB2/PTPRC/DNM2/LAT/FCGR3B/MAP2K1/PLA2G4F/PRKCD/PIP5K1A/FCGR1A/CRK/SCIN/BIN1/GSN/PLCG1/FCGR2B/ASAP3/PIP5K1B/WASF3/CFL2/PRKCG/RPS6KB1/SPHK2/MYO10/ACTR2/WASF2/FCGR3A/PRKCA/SPHK1/MARCKS/PIK3R3/ASAP2/PLA2G4A/DOCK1/AMPH/WASF1/PRKCE	90
KEGG	hsa04713	Circadian entrainment	90/6408	97/8135	0.0001503	0.0006276	0.0002413	GNG13/GRIA2/RYR3/GNG5/CAMK2G/PLCB2/PRKACA/PRKG2/GNB1/GNAQ/GNG2/PRKCB/GNG10/CALML6/KCNJ6/CACNA1C/GNAI1/GNAI3/MAPK1/GRIN2B/GNAS/GNGT2/ADCY8/ITPR3/PLCB4/MAPK3/GNB2/CALM2/ADCY6/GNB5/GUCY1A2/ADCY4/RASD1/CALM1/GNAI2/PLCB3/CACNA1H/GRIA3/GNB3/ADCY7/GNG3/KCNJ5/CAMK2B/MTNR1B/GNAO1/PER2/GNG7/GNG11/GRIN2C/CALML4/PER1/ADCYAP1R1/CALML5/ITPR1/GRIN1/FOS/GNG8/PRKACB/NOS1AP/CACNA1I/RYR1/CREB1/ADCY9/GNB4/GNGT1/GNG12/ADCY3/CALM3/GRIN2D/PRKACG/CALML3/CAMK2D/PRKCG/RPS6KA5/CACNA1D/CAMK2A/GRIA4/KCNJ3/PLCB1/PRKCA/MTNR1A/GRIN2A/CACNA1G/GRIA1/ADCY1/GNG4/RYR2/PRKG1/ADCYAP1/ADCY2	90
KEGG	hsa05134	Legionellosis	55/6408	57/8135	0.0001578	0.0006506	0.0002502	IL12A/ITGB2/CASP9/RAB1B/MYD88/RAB1A/NLRC4/ITGAM/HSPA6/ARF1/CASP3/VCP/CASP8/IL1B/CD14/PYCARD/EEF1A1/HSF1/NFKBIA/TLR5/TNF/HSPA8/HSPA1L/CASP1/CXCL1/HSPA1A/HBS1L/NAIP/CR1/CLK4/NFKB2/SAR1B/CLK1/HSPD1/RELA/C3/EEF1A2/NFKB1/APAF1/CXCL3/BNIP3/TLR2/SAR1A/CYCS/HSPA1B/IL12B/EEF1G/SEC22B/CASP7/CR1L/IL18/BCL2L13/TLR4/IL6/HSPA2	55
KEGG	hsa04915	Estrogen signaling pathway	125/6408	138/8135	0.0001661	0.0006636	0.0002551	KRT13/KRT12/KRT20/KRT34/KRT27/PGR/AKT2/NCOA3/GRB2/PLCB2/ATF4/PRKACA/PIK3CB/SHC1/GNAQ/CREB3/SOS1/CALML6/KCNJ6/MAP2K2/HSP90B1/GNAI1/GNAI3/NCOA1/HSPA6/PIK3CD/MAPK1/SHC3/AKT1/GNAS/AKT3/ATF6B/ADCY8/ITPR3/PLCB4/KRT32/NOS3/RAF1/MAPK3/PIK3R1/CALM2/ADCY6/CREB5/KRT33B/KRT24/HRAS/PIK3R2/PIK3CA/HSPA8/ITPR2/HSPA1L/ADCY4/CALM1/HSPA1A/GNAI2/PLCB3/JUN/RARA/GABBR1/KRT19/ADCY7/KCNJ5/CTSD/MAP2K1/ESR2/GNAO1/FKBP4/HSP90AA1/PRKCD/SOS2/CALML4/MMP9/ATF2/CALML5/ITPR1/POMC/KRAS/CREB3L4/CREB3L2/FOS/PRKACB/HSPA1B/KRT38/KRT25/CREB1/ADCY9/KRT23/MMP2/ADCY3/KRT36/CALM3/PRKACG/KRT15/SRC/CALML3/HSP90AB1/GABBR2/TGFA/FKBP5/NCOA2/KRT18/KRT14/KCNJ3/KRT10/ESR1/KRT40/KRT35/PLCB1/SHC2/NRAS/BCL2/SHC4/PIK3R3/KRT16/KRT9/HBEGF/OPRM1/ADCY1/EBAG9/KRT37/ADCY2/CREB3L1/KRT33A/KRT17/HSPA2	125
KEGG	hsa04211	Longevity regulating pathway	83/6408	89/8135	0.0001669	0.0006636	0.0002551	ADIPOQ/ADIPOR2/AKT2/IGF1/ATF4/PRKACA/PIK3CB/RPTOR/CREB3/TSC1/RPS6KB2/EHMT2/ATG5/PIK3CD/MTOR/TSC2/AKT1/AKT1S1/PRKAB1/AKT3/ATF6B/ADCY8/RB1CC1/IRS2/RHEB/PIK3R1/STK11/EIF4E2/ADCY6/CREB5/EIF4EBP1/BAX/HRAS/PIK3R2/EHMT1/PRKAG1/CAMKK2/CAT/PIK3CA/ADCY4/PRKAG2/SESN1/PRKAA1/IRS1/ADCY7/SESN2/RELA/ULK1/NFKB1/IGF1R/ATF2/FOXO1/KRAS/CREB3L4/SOD2/CREB3L2/PRKACB/IRS4/SIRT1/CREB1/ADCY9/ADCY3/EIF4E/APPL1/PRKACG/INSR/INS/RPS6KB1/TP53/ADIPOR1/NRAS/FOXO3/PIK3R3/ADCY1/PRKAG3/KL/PRKAA2/CAMK4/PPARG/ADCY2/CREB3L1/PRKAB2/SESN3	83
KEGG	hsa04727	GABAergic synapse	83/6408	89/8135	0.0001669	0.0006636	0.0002551	GABRA6/GABRG2/GNG13/SLC6A1/GABRE/GABRR1/GABRA4/GABRA2/GNG5/GABRB1/PRKACA/NSF/GNB1/SLC12A5/GNG2/PRKCB/GNG10/GABARAP/KCNJ6/CACNA1C/GNAI1/GNAI3/SLC32A1/GLS/GLUL/GNGT2/ADCY8/SLC6A11/GNB2/ADCY6/GNB5/ADCY4/GABARAPL1/GABARAPL2/HAP1/GNAI2/SLC38A2/GABBR1/GNB3/ADCY7/GNG3/GABRP/GNAO1/GNG7/GNG11/ABAT/CACNA1F/GNG8/PRKACB/GABRA1/CACNA1S/ADCY9/GNB4/GNGT1/GNG12/ADCY3/PRKACG/TRAK2/SRC/GABBR2/PRKCG/SLC38A3/CACNA1D/CACNA1B/GABRA3/SLC38A5/GAD2/GABRG1/PRKCA/PLCL1/GLS2/GABRD/GABRA5/GABRG3/SLC6A12/GABRB3/ADCY1/GAD1/GNG4/SLC38A1/GABRR3/ADCY2/GPHN	83
KEGG	hsa04611	Platelet activation	113/6408	124/8135	0.0001804	0.0007088	0.0002725	AKT2/TLN1/ACTG1/PLCB2/PRKACA/GNA13/MAPK14/PIK3CB/PRKG2/STIM1/BTK/RHOA/GNAQ/PTGS1/SYK/ARHGEF1/PLA2G4D/ITGA2/APBB1IP/PIK3R5/GNAI1/GNAI3/VASP/GP9/FCGR2A/PIK3CD/MYLK2/MAPK1/AKT1/PLA2G4C/GNAS/LCP2/AKT3/F2RL3/FGB/ADCY8/ITPR3/PLCB4/NOS3/VWF/MAPK3/ROCK1/FYN/GP6/MYL12A/MYL12B/PLCG2/PIK3R1/ITGA2B/ADCY6/MAPK11/FERMT3/PPP1R12A/ACTB/MAPK13/PIK3R2/FCER1G/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/GUCY1A2/RAP1A/ITPR2/MAPK12/ADCY4/F2R/GNAI2/PLCB3/LYN/TLN2/SNAP23/ROCK2/GP5/ADCY7/PRKCZ/ORAI1/RASGRP2/PPP1CA/PLA2G4F/MYLK3/GP1BB/RAP1B/RASGRP1/GP1BA/P2RY12/VAMP8/ITPR1/P2RX1/PRKACB/TBXA2R/ITGB3/ADCY9/ADCY3/MYLK/TBXAS1/PRKACG/ITGB1/SRC/PIK3CG/PTGIR/PPP1CC/PIK3R6/COL1A1/PPP1CB/PLCB1/PIK3R3/PLA2G4A/ADCY1/F2/PRKG1/FGA/ADCY2/COL3A1	113
KEGG	hsa04510	Focal adhesion	178/6408	201/8135	0.0001848	0.0007176	0.0002759	COL6A6/TNN/PAK1/BAD/ITGA11/AKT2/IGF1/TLN1/DIAPH1/ACTG1/GRB2/RAC1/PIK3CB/ITGA5/SHC1/RHOA/ZYX/PXN/VCL/ITGB4/RAC2/PRKCB/ILK/VAV1/SOS1/ITGA2/CCND1/THBS4/ACTN1/VASP/PARVG/PIK3CD/MYLK2/MAPK1/FLNC/SHC3/AKT1/AKT3/PDGFRB/ELK1/PIP5K1C/PTEN/CRKL/MAPK9/BRAF/VWF/RAF1/LAMB1/MAPK3/ROCK1/FYN/MYL12A/MYL12B/LAMA3/CCND3/BCAR1/PIK3R1/LAMA1/ITGA2B/VTN/LAMA2/THBS1/MYLPF/ITGB7/PPP1R12A/VEGFC/BIRC2/ACTB/TNXB/CAPN2/ACTN4/HRAS/PIK3R2/PARVB/PIK3CA/RAP1A/VAV2/THBS3/XIAP/ITGA8/FLT4/CDC42/COL6A1/TLN2/MYL10/JUN/ITGB5/PAK2/ROCK2/PTK2/MAP2K1/PPP1R12C/PPP1CA/HGF/VEGFA/ITGA9/ITGAV/IGF1R/VEGFB/SOS2/MYLK3/PIP5K1A/FLT1/RAP1B/CRK/ARHGAP5/COL9A3/CCND2/ITGA7/PAK4/ITGA10/PDGFD/PPP1R12B/COL9A1/FLNB/ITGA4/MAPK8/EGF/ITGB3/COL4A3/PIP5K1B/COL4A5/PDGFB/RAPGEF1/MYLK/FLNA/COL9A2/PGF/PDGFC/ITGB1/SRC/COMP/PRKCG/LAMC1/COL4A2/PPP1CC/MYL9/THBS2/KDR/COL1A1/COL4A6/PARVA/BIRC3/CHAD/PPP1CB/PDGFA/LAMA5/CTNNB1/COL6A3/MYL7/SHC2/PRKCA/LAMB2/ITGB8/BCL2/LAMC3/CAV2/SHC4/PIK3R3/FN1/LAMC2/DOCK1/PDPK1/PAK3/MAPK10/LAMB4/MYL5/COL4A1/LAMA4/MET/ITGA3/PDGFRA/COL6A2/PAK6/SPP1/GSK3B/CAV3/RASGRF1	178
KEGG	hsa05218	Melanoma	68/6408	72/8135	0.0002241	0.0008602	0.0003307	FGF5/FGF1/BAD/AKT2/IGF1/E2F1/MDM2/GADD45B/PIK3CB/FGF3/CCND1/MAP2K2/FGF18/ARAF/PIK3CD/MAPK1/AKT1/AKT3/PDGFRB/PTEN/BRAF/RAF1/MAPK3/PIK3R1/CDKN1A/DDB2/FGF23/BAK1/BAX/HRAS/PIK3R2/PIK3CA/MITF/POLK/MAP2K1/FGF10/HGF/CDKN2A/IGF1R/E2F3/GADD45A/FGF6/GADD45G/KRAS/PDGFD/FGF7/FGF4/FGF16/EGF/PDGFB/PDGFC/FGF17/CDK4/TP53/RB1/FGF22/FGF2/PDGFA/FGF19/FGFR1/NRAS/CDK6/FGF20/PIK3R3/E2F2/FGF9/MET/PDGFRA	68
KEGG	hsa04657	IL-17 signaling pathway	87/6408	94/8135	0.0002495	0.0009471	0.0003642	MMP3/USP25/MAPK14/IL17RA/CEBPB/S100A9/IKBKG/HSP90B1/TBK1/S100A8/MAPK1/TRAF4/TRADD/TNFAIP3/FADD/MAPK9/IL17A/MAPK3/CASP3/CASP8/IL1B/TRAF6/ANAPC5/MAPK11/TRAF2/NFKBIA/JUND/MAPK13/IKBKB/MAPK6/TAB2/TNF/TRAF3IP2/MAPK12/MUC5B/IL25/CXCL1/MAPK7/JUN/MAP3K7/RELA/TAB3/CSF2/HSP90AA1/NFKB1/TRAF3/IKBKE/CXCL3/MMP9/S100A7/CSF3/PTGS2/IL4/FOS/MAPK8/IL13/ELAVL1/IL17D/HSP90AB1/MUC5AC/IL17RC/CCL7/MAPK4/S100A7A/LCN2/IL17C/TRAF5/DEFB4A/CHUK/MMP1/FOSB/MMP13/IFNG/CCL20/CXCL6/MAPK10/CCL2/IL17RE/CCL17/MAPK15/CXCL5/CCL11/IL6/IL17B/IL17F/IL17RB/GSK3B	87
KEGG	hsa04931	Insulin resistance	99/6408	108/8135	0.0002562	0.0009613	0.0003696	GYS2/PPP1R3A/SLC2A2/PCK1/SLC27A4/AKT2/PTPN1/PPARA/PIK3CB/CREB3/PRKCB/PPP1R3D/RPS6KB2/MLX/PIK3CD/RPS6KA1/MLXIP/TNFRSF1A/MTOR/AKT1/PRKAB1/AKT3/RPS6KA3/PTEN/MAPK9/PPP1R3B/NOS3/IRS2/PYGL/PIK3R1/CREB5/G6PC/NFKBIA/PIK3R2/IKBKB/PRKAG1/PIK3CA/CPT1B/TNF/PCK2/PRKAG2/PYGM/CD36/SLC27A5/SLC27A3/PRKAA1/IRS1/CPT1A/PRKCZ/RELA/GYS1/SLC27A1/PPP1CA/RPS6KA2/PYGB/NFKB1/PPP1R3E/PRKCD/SREBF1/NR1H3/PRKCQ/GFPT2/SLC27A2/CRTC2/FOXO1/G6PC2/CREB3L4/CREB3L2/SLC2A1/MAPK8/G6PC3/CREB1/SOCS3/TRIB3/GFPT1/PPP1R3C/NR1H2/INSR/PTPN11/INS/PPP1CC/STAT3/RPS6KB1/PPP1CB/ACACB/PIK3R3/RPS6KA6/PDPK1/MAPK10/PTPRF/PRKAG3/PRKAA2/SLC2A4/IL6/CREB3L1/PRKAB2/GSK3B/TBC1D4/PRKCE	99
KEGG	hsa04022	cGMP-PKG signaling pathway	149/6408	167/8135	0.0002653	0.0009844	0.0003785	KCNMB2/KCNU1/SLC25A31/CNGA1/ADRA1D/BAD/SRF/AKT2/PLCB2/ATF4/GNA13/PRKG2/RHOA/GNAQ/NPPA/PPP3R2/CREB3/ATP2A2/CALML6/ADRA2B/MAP2K2/GTF2I/GNA11/PIK3R5/CACNA1C/GNAI1/SLC25A4/GNAI3/VASP/VDAC2/NFATC1/MYLK2/MAPK1/AKT1/ATP1B3/ADRA1A/AKT3/ATF6B/NPR1/PPIF/ADCY8/PPP3CB/ITPR3/PLCB4/ATP2A3/NOS3/RAF1/MAPK3/ROCK1/RGS2/IRS2/VDAC3/CALM2/MEF2D/ADCY6/ATP2B2/CREB5/PPP1R12A/ATP2B1/PLN/GUCY1A2/ITPR2/CNGB1/ADCY4/SLC25A5/CALM1/MEF2A/GNAI2/PLCB3/IRS1/ROCK2/ADORA3/MRVI1/ADCY7/MAP2K1/AGTR1/PPP1CA/MYH6/MYLK3/PPP3CA/KCNMB3/CALML4/PDE3A/ATP2B3/ATF2/NFATC2/CALML5/CACNA1F/ITPR1/ATP2B4/MEF2C/NPR2/PDE2A/CREB3L4/CREB3L2/ADORA1/IRS4/CACNA1S/GNA12/FXYD2/SLC8A3/CREB1/ADCY9/ATP1A1/ADRA2C/ADCY3/MYLK/KNG1/CALM3/INSR/SLC8A1/CALML3/MYH7/ADRB2/PIK3CG/INS/PPP1CC/MYL9/KCNJ8/PIK3R6/PPP3CC/CACNA1D/KCNMB1/PPP1CB/NFATC4/PLCB1/EDNRA/NPPC/PDE3B/ADRB1/NFATC3/PPP3R1/EDNRB/OPRD1/ADCY1/SLC25A6/ADRA2A/GTF2IRD1/PRKG1/VDAC1/BDKRB2/ATP1A4/ADCY2/CREB3L1/ATP1A3/NPPB/ATP1A2/PDE5A/PRKCE	149
KEGG	hsa04922	Glucagon signaling pathway	98/6408	107/8135	3e-04	0.001101	0.0004234	GYS2/LDHAL6B/SLC2A2/GCG/PCK1/PGAM1/AKT2/PPARA/CAMK2G/PLCB2/ATF4/PRKACA/GNAQ/FBP1/PPP3R2/CREB3/CALML6/LDHAL6A/PHKA2/CPT1C/PDHA2/PGAM2/GCGR/AKT1/EP300/GNAS/PRKAB1/AKT3/PPP3CB/PHKG2/ITPR3/PLCB4/PFKP/PYGL/CALM2/CREB5/G6PC/PHKB/PDHB/PRKAG1/CPT1B/ITPR2/PCK2/PRKAG2/CALM1/PYGM/PLCB3/LDHA/PDHA1/PRKAA1/CPT1A/GCK/GYS1/CAMK2B/PYGB/PPP3CA/PPP4C/PFKM/CALML4/PFKL/CRTC2/ATF2/CALML5/FOXO1/G6PC2/ITPR1/SIK1/LDHB/CREB3L4/CREB3L2/PRKACB/SLC2A1/ACACA/SIRT1/PHKG1/G6PC3/CREB1/PRMT1/CALM3/PRKACG/CALML3/CAMK2D/PPP3CC/CAMK2A/PHKA1/PLCB1/LDHC/PDE3B/ACACB/CREBBP/PPP3R1/PRKAG3/SIK2/PRKAA2/ADCY2/CREB3L1/FBP2/PRKAB2	98
KEGG	hsa04917	Prolactin signaling pathway	66/6408	70/8135	0.0003252	0.001181	0.000454	LHCGR/SLC2A2/CSN2/IRF1/AKT2/GRB2/MAPK14/PIK3CB/SHC1/STAT5B/SOS1/CCND1/MAP2K2/STAT5A/PIK3CD/MAPK1/SHC3/AKT1/AKT3/MAPK9/RAF1/MAPK3/CISH/JAK2/PIK3R1/MAPK11/MAPK13/HRAS/PIK3R2/PIK3CA/MAPK12/CGA/STAT1/GCK/RELA/MAP2K1/GALT/ESR2/NFKB1/SOS2/CCND2/KRAS/SOCS5/FOS/MAPK8/CYP17A1/ELF5/SOCS3/SOCS1/SOCS4/SRC/PRLR/INS/STAT3/ESR1/SOCS2/TH/SHC2/NRAS/FOXO3/SHC4/PIK3R3/SOCS7/MAPK10/LHB/GSK3B	66
KEGG	hsa04610	Complement and coagulation cascades	79/6408	85/8135	0.000334	0.001199	0.0004612	F9/MBL2/CFHR4/CPB2/PLAT/F13B/C9/ITGB2/TFPI/SERPINA5/SERPINA1/C1R/ITGAM/CD46/C4BPB/C6/CD55/F2RL3/FGB/VWF/CFI/C2/CD59/F3/VTN/F11/PLG/F2R/F7/KLKB1/C5AR1/CR1/F12/PLAUR/CLU/ITGAX/C1QB/C3/CFHR3/CFB/PROC/CFHR5/C5/C1QA/F8/PLAU/C3AR1/A2M/SERPING1/SERPINE1/CFD/PROCR/SERPIND1/F13A1/KNG1/F5/MASP2/F2RL2/F10/CR1L/VSIG4/C1S/SERPINC1/C8A/MASP1/C4A/C4B/C1QC/C4BPA/PROS1/CFH/CFHR1/F2/THBD/BDKRB2/FGA/SERPINF2/BDKRB1/CFHR2	79
KEGG	hsa04725	Cholinergic synapse	103/6408	113/8135	0.0003429	0.001219	0.0004685	GNG13/SLC5A7/CHRM2/AKT2/GNG5/CAMK2G/PLCB2/ATF4/PRKACA/CHRNA4/PIK3CB/GNB1/GNAQ/CHRNB4/GNG2/CREB3/PRKCB/GNG10/KCNJ6/GNA11/PIK3R5/CACNA1C/GNAI1/GNAI3/CHRNB2/PIK3CD/MAPK1/AKT1/AKT3/GNGT2/ADCY8/KCNQ4/ITPR3/PLCB4/MAPK3/GNB2/FYN/JAK2/PIK3R1/KCNQ1/ADCY6/CREB5/CHRNA3/GNB5/HRAS/PIK3R2/PIK3CA/ITPR2/CHRM3/ADCY4/KCNJ12/GNAI2/PLCB3/CHRM4/KCNJ2/GNB3/ADCY7/GNG3/MAP2K1/CAMK2B/KCNJ4/GNAO1/GNG7/GNG11/CACNA1F/ITPR1/KRAS/CREB3L4/CREB3L2/FOS/GNG8/PRKACB/CACNA1S/CHRNA7/CREB1/ADCY9/GNB4/GNGT1/GNG12/ADCY3/PRKACG/CAMK2D/PIK3CG/PRKCG/PIK3R6/CACNA1D/CAMK2A/CHRM5/KCNJ3/CACNA1B/CHRM1/KCNQ2/PLCB1/PRKCA/NRAS/BCL2/PIK3R3/ADCY1/SLC18A3/GNG4/CAMK4/ADCY2/CREB3L1	103
KEGG	hsa04130	SNARE interactions in vesicular transport	33/6408	33/8135	0.0003736	0.001314	0.0005051	STX19/VAMP3/STX8/YKT6/VAMP5/STX3/GOSR2/SNAP29/STX5/STX16/STX7/GOSR1/STX18/STX4/USE1/BNIP1/VAMP1/SNAP23/STX1A/STX17/STX11/BET1L/VAMP7/VAMP8/VAMP2/VTI1B/VAMP4/SEC22B/STX2/BET1/STX6/STX1B/VTI1A	33
KEGG	hsa04071	Sphingolipid signaling pathway	108/6408	119/8135	0.0003836	0.001335	0.0005132	SMPD2/PPP2R5D/PPP2R5C/AKT2/PPP2CA/PLCB2/RAC1/GNA13/MAPK14/PIK3CB/RHOA/GNAQ/PPP2R2C/RAC2/PRKCB/MAP2K2/SPTLC3/PPP2R5B/GNAI1/GNAI3/ASAH2/PIK3CD/TNFRSF1A/MAPK1/PPP2R2D/AKT1/TRADD/PLD2/AKT3/PTEN/S1PR4/ABCC1/MAPK9/PLCB4/NOS3/RAF1/MAPK3/ROCK1/FYN/NSMAF/PIK3R1/MAPK11/SMPD1/PPP2R2A/TRAF2/SPTLC1/PLD1/BAX/MAPK13/BID/HRAS/PIK3R2/DEGS1/FCER1G/PPP2R3C/PIK3CA/MAP3K5/TNF/MAPK12/GNAI2/PLCB3/GAB2/ROCK2/ADORA3/SPTLC2/PRKCZ/RELA/CTSD/MAP2K1/NFKB1/PPP2R1A/PPP2R2B/PPP2R5A/SGMS1/PPP2R3B/KRAS/ADORA1/MAPK8/GNA12/KNG1/ASAH1/PRKCG/SGPL1/TP53/SPHK2/PPP2CB/S1PR2/PLCB1/DEGS2/PRKCA/NRAS/BCL2/SPHK1/PIK3R3/PPP2R1B/FCER1A/PDPK1/PPP2R5E/SGMS2/S1PR3/MAPK10/S1PR1/OPRD1/SGPP1/PPP2R3A/BDKRB2/S1PR5/PRKCE	108
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	90/6408	98/8135	0.0004153	0.001416	0.0005443	HTR2C/HRH1/IGF1/CAMK2G/PLCB2/PRKACA/MAPK14/PIK3CB/GNAQ/PRKCB/PLA2G4D/CALML6/PTGER4/PIK3CD/PLA2G4C/GNAS/ADCY8/MAPK9/ITPR3/PLCB4/PLCG2/PIK3R1/CALM2/ADCY6/IL1B/MAPK11/PLA2G6/MAPK13/PIK3R2/PTGER2/TRPV3/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/ITPR2/MAPK12/ADCY4/HTR2A/CYP2J2/TRPV2/TRPA1/CALM1/PLCB3/HTR2B/ADCY7/MAP2K6/PRKCH/TRPV1/F2RL1/ALOX12/CAMK2B/PPP1CA/NTRK1/PLA2G4F/PRKCD/PRKCQ/CALML4/CALML5/ITPR1/PRKACB/PLCG1/MAPK8/ADCY9/ADCY3/KNG1/CALM3/PRKACG/SRC/CALML3/CAMK2D/P2RY2/PRKCG/PPP1CC/CAMK2A/PPP1CB/PLCB1/MAP2K3/PRKCA/PIK3R3/PLA2G4A/MAPK10/IL1R1/ADCY1/BDKRB2/ADCY2/TRPV4/BDKRB1/IL1RAP/PRKCE/NGF	90
KEGG	hsa04925	Aldosterone synthesis and secretion	90/6408	98/8135	0.0004153	0.001416	0.0005443	HSD3B1/CAMK2G/PLCB2/ATF4/PRKACA/GNAQ/NPPA/CREB3/PRKCB/CALML6/GNA11/CACNA1C/GNAS/ATP1B3/MC2R/ATF6B/NPR1/PRKD2/ADCY8/ITPR3/PLCB4/DAGLA/CALM2/ADCY6/ATP2B2/CREB5/HSD3B2/ATP2B1/CYP11B2/ITPR2/ADCY4/DAGLB/CALM1/PLCB3/LDLR/CACNA1H/STAR/ADCY7/KCNJ5/CYP11A1/ORAI1/CAMK2B/AGTR1/CAMK1D/CYP21A2/PRKD1/CALML4/ATP2B3/ATF2/NR4A1/CALML5/CACNA1F/ITPR1/ATP2B4/POMC/PDE2A/CREB3L4/CREB3L2/PRKACB/CACNA1I/CACNA1S/CREB1/ADCY9/ATF1/ATP1A1/ADCY3/SCARB1/CALM3/PRKACG/CALML3/CAMK2D/PRKCG/KCNK3/KCNK9/CACNA1D/CAMK2A/PLCB1/PRKCA/CAMK1G/NR4A2/CACNA1G/CAMK1/ADCY1/CAMK4/ATP1A4/ADCY2/CREB3L1/ATP1A3/ATP1A2/PRKCE	90
KEGG	hsa04940	Type I diabetes mellitus	42/6408	43/8135	0.0004298	0.00145	0.0005575	IL12A/IL2/HLA-E/ICA1/HLA-B/HLA-C/HLA-A/FAS/IL1B/TNF/HLA-G/HLA-F/HSPD1/HLA-DMB/CD86/HLA-DMA/LTA/IL12B/PTPRN2/HLA-DRA/INS/HLA-DPA1/CD80/PRF1/GZMB/HLA-DOA/HLA-DQB1/GAD2/CD28/FASLG/IFNG/PTPRN/HLA-DOB/GAD1/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/CPE/IL1A	42
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	118/6408	131/8135	0.0004564	0.001524	0.0005861	IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/PTPN6/PAK1/PTK2B/ITGB2/GRB2/RAC1/IFNGR2/PIK3CB/SHC1/SYK/PPP3R2/HLA-B/RAC2/HLA-C/PRKCB/TYROBP/VAV1/SOS1/MAP2K2/NCR1/NFATC1/ARAF/PIK3CD/IFNAR1/MAPK1/SHC3/LCP2/ITGAL/PPP3CB/HLA-A/BRAF/RAF1/FAS/MAPK3/FYN/CASP3/PLCG2/PIK3R1/IFNGR1/TNFRSF10B/BID/HRAS/PIK3R2/FCER1G/PIK3CA/NCR2/ICAM2/TNF/MICA/VAV2/KIR2DL3/KIR2DL5A/KIR2DS1/KIR2DS3/HLA-G/ICAM1/TNFSF10/LAT/FCGR3B/MAP2K1/CSF2/IFNA8/SOS2/RAET1E/PPP3CA/CD244/LCK/NFATC2/ZAP70/KRAS/TNFRSF10A/PLCG1/ULBP1/KIR3DL2/MICB/IFNAR2/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/PTPN11/PRKCG/HCST/PPP3CC/PRF1/NCR3/KIR2DS5/GZMB/KIR2DL2/SHC2/FCGR3A/PRKCA/NRAS/SH3BP2/FASLG/SHC4/PIK3R3/KIR2DL1/IFNG/PPP3R1/KIR3DL3/KIR2DS2/KIR2DS4/KLRD1/IFNA17/ULBP2/KLRK1/KLRC3/CD48	118
KEGG	hsa05221	Acute myeloid leukemia	63/6408	67/8135	0.0005654	0.00187	0.0007189	BAD/AKT2/GRB2/BCL2A1/PIK3CB/STAT5B/SOS1/RPS6KB2/CCND1/MAP2K2/STAT5A/IKBKG/ITGAM/RUNX1/ARAF/PIK3CD/MAPK1/MTOR/AKT1/AKT3/SPI1/BRAF/RAF1/KIT/MAPK3/PIK3R1/CD14/CSF1R/EIF4EBP1/HRAS/PIK3R2/IKBKB/PIK3CA/TCF7/RARA/PIM2/RELA/MAP2K1/PML/CEBPE/PER2/CSF2/NFKB1/SOS2/CCNA2/FCGR1A/TCF7L2/IL3/KRAS/PPARD/CEBPA/MPO/STAT3/RPS6KB1/DUSP6/RUNX1T1/FLT3/NRAS/CHUK/PIK3R3/JUP/PIM1/MYC	63
KEGG	hsa00410	beta-Alanine metabolism	31/6408	31/8135	0.0006034	0.001976	0.0007597	CNDP1/HADHA/ACADS/ALDH9A1/MLYCD/ECHS1/ACOX1/ALDH2/UPB1/HIBCH/ALDH3B1/AOC3/ALDH1B1/SMOX/ALDH7A1/AOC2/ABAT/CSAD/ACOX3/DPYD/CNDP2/ALDH3A2/CARNS1/ALDH3A1/GADL1/ALDH3B2/GAD2/DPYS/GAD1/EHHADH/ALDH6A1	31
KEGG	hsa05030	Cocaine addiction	47/6408	49/8135	0.000811	0.002614	0.001005	GRIA2/ATF4/PRKACA/CREB3/GNAI1/GNAI3/GRIN2B/GNAS/ATF6B/CREB5/DLG4/GPSM1/RGS9/GNAI2/CDK5/JUN/DRD1/RELA/NFKB1/GRIN2C/MAOA/ATF2/GRM2/GRIN1/CREB3L4/CREB3L2/PRKACB/CREB1/GRIN2D/PRKACG/DRD2/SLC18A2/BDNF/TH/GRIN3B/FOSB/GRM3/GRIN2A/SLC18A1/MAOB/GRIN3A/SLC6A3/CDK5R1/CREB3L1/PDYN/PPP1R1B/DDC	47
KEGG	hsa05321	Inflammatory bowel disease	61/6408	65/8135	0.000814	0.002614	0.001005	IL12A/IL2/IFNGR2/IL2RG/STAT6/TGFB1/TGFB2/NFATC1/SMAD2/IL17A/IL22/IL10/IL12RB1/IL1B/NOD2/IFNGR1/SMAD3/IL23A/TLR5/IL4R/TNF/IL12RB2/JUN/STAT1/HLA-DMB/RELA/IL18RAP/NFKB1/FOXP3/TLR2/IL21R/RORC/IL4/HLA-DMA/IL21/GATA3/IL12B/IL13/HLA-DRA/STAT4/STAT3/HLA-DPA1/IL18/IL18R1/HLA-DOA/HLA-DQB1/IFNG/TLR4/IL23R/HLA-DOB/HLA-DQA1/HLA-DQA2/MAF/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/IL6/TBX21/IL17F/IL1A	61
KEGG	hsa04137	Mitophagy - animal	67/6408	72/8135	0.0008862	0.002798	0.001076	NBR1/E2F1/ATF4/USP15/TBC1D17/CALCOCO2/UBC/GABARAP/TFE3/MAP1LC3B/RHOT2/CSNK2B/ATG5/TBK1/PINK1/TAX1BP1/PGAM5/SQSTM1/MAPK9/RRAS/USP8/TOMM7/FUNDC1/MAP1LC3A/MFN2/AMBRA1/USP30/ATG9A/HRAS/BCL2L1/TFEB/UBA52/MITF/GABARAPL1/GABARAPL2/BECN1/CSNK2A2/JUN/EIF2AK3/RELA/CSNK2A1/ULK1/RAB7A/RHOT1/MAP1LC3C/HIF1A/BNIP3/TBC1D15/KRAS/RAB7B/MAPK8/SRC/ATG9B/TP53/MAP1LC3B2/CITED2/MFN1/OPTN/FIS1/NRAS/FOXO3/MAPK10/RPS27A/BCL2L13/MRAS/UBB/RRAS2	67
KEGG	hsa04360	Axon guidance	160/6408	182/8135	0.0008881	0.002798	0.001076	DCC/UNC5D/TRPC5/PARD6A/EFNA3/PAK1/RGMA/RHOD/SEMA3B/SEMA6B/CAMK2G/CFL1/RAC1/PIK3CB/PLXNA3/RHOA/PLXNA2/NCK2/RND1/PPP3R2/NTN1/SEMA6C/RAC2/ILK/UNC5A/SEMA3G/GNAI1/SRGAP3/GNAI3/DPYSL5/PIK3CD/MAPK1/LIMK1/FES/NGEF/SEMA4B/PPP3CB/LIMK2/ABLIM2/EFNA4/RGS3/RAF1/MAPK3/ROCK1/FYN/RRAS/SEMA3F/MYL12A/MYL12B/ABLIM3/PLCG2/PIK3R1/SSH3/LRRC4/HRAS/PIK3R2/SEMA4D/PIK3CA/BMP7/EPHA6/SRGAP2/NTNG2/GNAI2/NCK1/CDC42/EPHB6/CDK5/SEMA4C/PLXNC1/SLIT1/PAK2/ROCK2/CXCR4/ROBO3/PRKCZ/LRIG2/PTK2/RASA1/SEMA4A/CAMK2B/SHH/PLXNA4/PARD3/ABL1/PPP3CA/PLXNB1/NTN3/EPHA1/NFATC2/PAK4/KRAS/DPYSL2/PLCG1/SEMA4G/ABLIM1/EPHB1/PARD6G/EPHA7/PLXNB2/WNT4/SLIT2/ITGB1/BOC/SRC/CAMK2D/NTN4/CFL2/PTPN11/SEMA5A/PLXNA1/MYL9/EPHB2/PPP3CC/CAMK2A/SSH2/SSH1/EPHB4/PTCH1/EPHA4/SEMA6D/WNT5B/EFNA5/SEMA7A/BMPR2/NFATC4/EFNA2/EPHB3/EPHA5/RYK/PRKCA/NRAS/BMPR1B/L1CAM/PIK3R3/PDPK1/PAK3/NFATC3/PPP3R1/EFNA1/WNT5A/EFNB3/PLXNB3/SLIT3/SEMA4F/UNC5C/EFNB1/FZD3/MYL5/PARD6B/MET/SEMA3A/EFNB2/SEMA5B/UNC5B/CXCL12/PAK6/NEO1/GSK3B/SEMA3D/EPHA3	160
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	73/6408	79/8135	0.0009226	0.00288	0.001107	BCL2L11/BAD/AKT2/IGF1/GRB2/PIK3CB/SHC1/PRKCB/SOS1/RPS6KB2/MAP2K2/ARAF/PIK3CD/MAPK1/SHC3/MTOR/GAS6/AKT1/NF1/AKT3/PDGFRB/RPS6/IL6R/PTEN/BRAF/RAF1/MAPK3/JAK2/PLCG2/PIK3R1/EIF4E2/EIF4EBP1/BAX/HRAS/PIK3R2/BCL2L1/PIK3CA/MAP2K1/HGF/VEGFA/IGF1R/SOS2/KRAS/PDGFD/FGFR2/PLCG1/EGF/PDGFB/EIF4E/PDGFC/SRC/PRKCG/TGFA/STAT3/KDR/RPS6KB1/NRG1/FGF2/ERBB3/PDGFA/SHC2/PRKCA/NRAS/FOXO3/BCL2/JAK1/SHC4/PIK3R3/GAB1/MET/IL6/PDGFRA/GSK3B	73
KEGG	hsa00280	Valine, leucine and isoleucine degradation	46/6408	48/8135	0.000992	0.003068	0.00118	AGXT2/ACAA1/HADHB/HADHA/AOX1/HMGCL/BCKDHA/ACADS/HADH/ALDH9A1/AACS/ACAA2/DLD/HSD17B10/ECHS1/PCCA/IVD/HMGCS1/ALDH2/HIBCH/OXCT2/ALDH1B1/ACAT1/DBT/ACSF3/PCCB/HMGCS2/IL4I1/ACADSB/AUH/ALDH7A1/ACAD8/ABAT/MCCC1/MCEE/HIBADH/BCAT1/OXCT1/ALDH3A2/ACAT2/BCAT2/BCKDHB/ACADM/MCCC2/EHHADH/ALDH6A1	46
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	133/6408	150/8135	0.001068	0.003274	0.001259	SCN4B/ACTC1/ADRA1D/PPP2R5D/PPP2R5C/AKT2/PPP2CA/CACNB3/CAMK2G/PLCB2/ATF4/PRKACA/MAPK14/CACNB1/GNAQ/PPP2R2C/CREB3/ATP2A2/CALML6/PPP2R5B/PIK3R5/CACNA1C/GNAI1/GNAI3/MAPK1/PPP2R2D/AKT1/GNAS/ATP1B3/ADRA1A/AKT3/ATF6B/ADCY8/TPM3/SLC9A1/PLCB4/ATP2A3/MAPK3/KCNQ1/CACNG1/CALM2/ADCY6/MAPK11/ATP2B2/CREB5/PPP2R2A/TNNT2/MAPK13/CACNA2D1/ATP2B1/PLN/CREM/PPP2R3C/CACNG8/MAPK12/AGTR2/ADCY4/CACNA2D4/CALM1/TNNC1/GNAI2/PLCB3/PPP1R1A/ADCY7/TPM4/CAMK2B/AGTR1/PPP1CA/MYH6/CACNA2D2/PPP2R1A/SCN1B/CALML4/PPP2R2B/SCN7A/PPP2R5A/ATP2B3/ATF2/PPP2R3B/CALML5/CACNA1F/ATP2B4/CREB3L4/CREB3L2/PRKACB/CACNA1S/FXYD2/SLC8A3/CREB1/ADCY9/ATP1A1/ADCY3/CALM3/PRKACG/SLC8A1/CALML3/MYH7/ADRB2/CAMK2D/PIK3CG/CACNB2/PPP1CC/RPS6KA5/PIK3R6/CACNA1D/PPP2CB/CAMK2A/CACNG4/RAPGEF4/CACNG3/PPP1CB/MYL4/PLCB1/TPM1/PRKCA/MYL3/BCL2/RAPGEF3/TPM2/PPP2R1B/ADRB1/PPP2R5E/ADCY1/RYR2/PPP2R3A/ATP1A4/ADCY2/CREB3L1/CACNG5/KCNE1/ATP1A3/CACNG2/ATP1A2	133
KEGG	hsa05032	Morphine addiction	83/6408	91/8135	0.001251	0.003765	0.001448	GABRA6/GABRG2/GNG13/GABRE/GABRR1/GABRA4/GABRA2/PDE8A/GNG5/GABRB1/PRKACA/GNB1/PDE1A/GNG2/PRKCB/ARRB1/GNG10/KCNJ6/GNAI1/GNAI3/SLC32A1/PDE4B/ARRB2/GNAS/GRK5/GNGT2/ADCY8/GRK6/GNB2/PDE1B/PDE4D/ADCY6/GNB5/ADCY4/PDE11A/GNAI2/GABBR1/GNB3/DRD1/ADCY7/GNG3/KCNJ5/GABRP/GNAO1/GRK4/GNG7/GNG11/PDE3A/PDE2A/ADORA1/GNG8/PRKACB/GABRA1/ADCY9/GNB4/GNGT1/GNG12/ADCY3/PDE7A/PRKACG/PDE10A/GABBR2/PRKCG/PDE7B/KCNJ3/PDE4C/CACNA1B/GABRA3/GABRG1/PRKCA/PDE3B/GABRD/GABRA5/GABRG3/OPRM1/PDE4A/GABRB3/ADCY1/GNG4/PDE8B/GABRR3/ADCY2/PDE1C	83
KEGG	hsa04622	RIG-I-like receptor signaling pathway	65/6408	70/8135	0.001251	0.003765	0.001448	IL12A/IFNA2/IFNB1/IFNA1/IFNA13/IFNE/OTUD5/MAPK14/NFKBIB/RIPK1/IKBKG/ATG5/TBK1/TRADD/ATG12/FADD/MAPK9/CYLD/DDX3X/CASP8/TRAF6/MAPK11/TRAF2/MAVS/NLRX1/IRF3/NFKBIA/MAPK13/IKBKB/TBKBP1/TNF/MAPK12/AZI2/IRF7/RNF125/MAP3K7/RELA/DDX58/IFNA8/NFKB1/TRAF3/IKBKE/SIKE1/IFIH1/DHX58/MAPK8/IL12B/ISG15/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/TRIM25/IFNA16/CASP10/MAP3K1/PIN1/CHUK/TANK/MAPK10/IFNW1/IFNA17	65
KEGG	hsa04064	NF-kappa B signaling pathway	94/6408	104/8135	0.001316	0.003926	0.001509	EDARADD/BCL2A1/GADD45B/UBE2I/CD40/BTK/SYK/PRKCB/CFLAR/EDA/MYD88/RIPK1/LTBR/IKBKG/CSNK2B/IRAK1/LTB/TNFRSF1A/TRADD/TNFAIP3/CARD11/TICAM1/CYLD/RELB/PLCG2/IL1B/CD14/IRAK4/TRAF6/PARP1/TRAF2/TIRAP/NFKBIA/BIRC2/BCL2L1/IKBKB/PIAS4/TAB2/TNF/LY96/CXCL1/XIAP/ICAM1/LYN/CSNK2A2/NFKB2/MALT1/MAP3K7/RELA/LAT/CSNK2A1/ERC1/TAB1/CCL19/DDX58/TAB3/ATM/CARD10/NFKB1/TRAF3/GADD45A/PRKCQ/CXCL3/LCK/GADD45G/TNFSF13B/ZAP70/PTGS2/PLAU/TRAF1/TICAM2/PLCG1/LTA/CCL21/EDA2R/CD40LG/BCL10/TNFSF14/TRIM25/CCL4/MAP3K14/CARD14/EDAR/BIRC3/TRAF5/BCL2/CHUK/CCL13/IL1R1/TLR4/VCAM1/BLNK/CXCL12/TNFRSF13C	94
KEGG	hsa04072	Phospholipase D signaling pathway	131/6408	148/8135	0.001374	0.004062	0.001562	PTK2B/CYTH1/AKT2/GRB2/PLCB2/GNA13/PIK3CB/SHC1/RHOA/SYK/GRM6/TSC1/PLA2G4D/SOS1/DGKD/MAP2K2/CXCR1/PIK3R5/LPAR2/PIK3CD/MAPK1/SHC3/MTOR/TSC2/AKT1/PLA2G4C/GNAS/AGPAT2/CYTH4/PLD2/AKT3/PDGFRB/PIP5K1C/ARF1/GRM8/ADCY8/AGPAT3/PLCB4/RAF1/KIT/MAPK3/FYN/RRAS/LPAR4/RHEB/PLCG2/PIK3R1/ADCY6/PLD1/RALA/HRAS/PIK3R2/PTGFR/FCER1G/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/RALGDS/ADCY4/F2R/ARF6/PLCB3/DGKQ/DGKZ/GAB2/DNM1/ADCY7/DNM2/MAP2K1/LPAR6/LPAR5/AGTR1/PLA2G4F/CXCR2/LPAR1/CYTH3/SOS2/PIP5K1A/RALB/DGKA/KRAS/PDGFD/GRM2/DGKE/PLCG1/AVP/GRM4/EGF/GNA12/AVPR2/PIP5K1B/ADCY9/PDGFB/ADCY3/AGPAT4/CYTH2/PDGFC/INSR/PIK3CG/PTPN11/DGKI/INS/DGKG/PIK3R6/SPHK2/AGPAT1/RAPGEF4/AVPR1A/PDGFA/PLCB1/SHC2/PRKCA/NRAS/SPHK1/SHC4/PIK3R3/RAPGEF3/PLA2G4A/GRM3/GAB1/FCER1A/MRAS/ADCY1/F2/PDGFRA/ADCY2/KITLG/DNM3/GRM7/DGKH/RRAS2	131
KEGG	hsa03015	mRNA surveillance pathway	88/6408	97/8135	0.001394	0.004085	0.00157	PABPC4L/PABPC5/PABPC1L2B/UPF1/PPP2R5D/SSU72/RNGTT/PPP2R5C/PPP2CA/CASC3/CSTF2/ETF1/PPP2R2C/WDR33/PPP2R5B/RNPS1/NXF1/SMG5/PPP2R2D/CPSF7/CPSF2/TARDBP/RBM8A/EIF4A3/FIP1L1/CPSF4/NCBP1/UPF2/NXT2/CPSF6/CLP1/CPSF3/PELO/PPP2R2A/PABPC1/SMG6/MAGOH/PPP2R3C/PAPOLB/PABPC1L/ACIN1/DDX19A/DDX19B/GLE1/HBS1L/PABPN1/UPF3A/PAPOLA/MAGOHB/PPP1CA/WDR82/NXF2/NXF2B/NXT1/PABPC3/PPP2R1A/PAPOLG/PPP2R2B/PPP2R5A/CSTF1/PPP2R3B/RNMT/CSTF2T/SMG1/DAZAP1/SYMPK/SAP18/CPSF1/GSPT1/PPP1CC/PPP2CB/NCBP2/SMG7/SRRM1/NUDT21/GSPT2/PPP1CB/MSI1/PNN/PPP2R1B/PPP2R5E/PCF11/UPF3B/MSI2/CSTF3/PPP2R3A/FUS/PABPC4	88
KEGG	hsa03050	Proteasome	44/6408	46/8135	0.001481	0.004275	0.001644	PSMD6/POMP/PSMB4/PSMA6/PSMA3/PSMA7/PSMB9/PSMB1/PSMC1/PSMC4/PSMD1/PSMA2/PSMD12/PSMB5/PSME1/PSMD2/PSMD13/PSMD7/PSMD4/ADRM1/PSMC6/PSMD9/PSMC2/PSME3/PSMA1/PSMC5/PSME2/PSMD11/PSMB10/PSMB8/PSMB3/PSMD8/PSMA4/PSMB7/PSMD14/PSMA5/PSMB6/PSMD3/PSMB2/PSMA8/PSMC3/PSMF1/PSME4/IFNG	44
KEGG	hsa05211	Renal cell carcinoma	64/6408	69/8135	0.001485	0.004275	0.001644	PAK1/BAD/AKT2/GRB2/RAC1/PIK3CB/EGLN2/SOS1/TFE3/MAP2K2/TGFB1/TGFB2/ARAF/PIK3CD/MAPK1/AKT1/EP300/AKT3/CRKL/BRAF/RAF1/MAPK3/EGLN1/PIK3R1/CDKN1A/HRAS/PIK3R2/FH/PIK3CA/RAP1A/CDC42/JUN/EGLN3/PAK2/MAP2K1/HGF/VEGFA/EPAS1/SOS2/RAP1B/CRK/HIF1A/PAK4/KRAS/RBX1/SLC2A1/PDGFB/RAPGEF1/CUL2/PTPN11/TGFA/PRCC/ARNT2/ETS1/ARNT/NRAS/PIK3R3/CREBBP/GAB1/PAK3/VHL/MET/FLCN/PAK6	64
KEGG	hsa04662	B cell receptor signaling pathway	75/6408	82/8135	0.001759	0.00502	0.00193	PTPN6/AKT2/INPPL1/GRB2/IFITM1/RAC1/PIK3CB/BTK/NFKBIB/SYK/PPP3R2/RAC2/PRKCB/VAV1/SOS1/LILRB5/MAP2K2/IKBKG/LILRB2/INPP5D/NFKBIE/NFATC1/PIK3CD/MAPK1/AKT1/AKT3/CARD11/LILRA2/LILRB3/PPP3CB/PIK3AP1/RAF1/MAPK3/PLCG2/PIK3R1/NFKBIA/HRAS/PIK3R2/IKBKB/LILRB4/PIK3CA/LILRA1/VAV2/LYN/JUN/MALT1/RELA/MAP2K1/NFKB1/SOS2/PPP3CA/NFATC2/CD81/KRAS/LILRA3/FOS/LILRB1/LILRA6/FCGR2B/BCL10/CD72/CD19/PPP3CC/RASGRP3/NRAS/CHUK/PIK3R3/NFATC3/PPP3R1/DAPP1/CD22/BLNK/CD79A/CD79B/GSK3B	75
KEGG	hsa05010	Alzheimer disease	325/6408	384/8135	0.001838	0.005201	0.002	FZD10/SLC25A31/RYR3/COX6A2/COX8C/SLC39A12/WNT2/COX7B2/NOX1/COX4I2/PSMD6/PIK3C3/NDUFS7/WNT9B/UQCRB/BAD/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/AKT2/NDUFB3/NDUFA1/PSMA6/NDUFS2/TUBA1A/PSMA3/CASP9/TUBA1C/IDE/PSMA7/PLCB2/ATF4/FZD2/PIK3CB/GNAQ/WNT3/LRP5/PIK3R4/PPP3R2/NCSTN/PSMB1/PSMC1/PSMC4/COX6B1/WNT7B/DVL1/WIPI2/COX8A/CSNK1E/ATP2A2/CALML6/RTN4/NDUFB10/APH1B/MAP2K2/PSMD1/WNT7A/KLC1/NDUFA4/IKBKG/GAPDH/NDUFV2/CACNA1C/SLC25A4/WNT8B/APP/CSNK2B/UQCRFS1/FRAT1/DVL2/VDAC2/SLC39A13/NDUFB4/ARAF/NDUFA10/PIK3CD/NDUFB2/UQCR10/PSMA2/APC2/PSMD12/PSMB5/TNFRSF1A/MAPK1/NDUFB11/TUBAL3/SLC11A2/GRIN2B/MTOR/AKT1/UQCRH/PSMD2/PSMD13/AKT3/COX7B/PSEN1/WNT16/SDHA/COX7A2/NDUFB6/PSMD7/NDUFB8/BACE1/PPIF/FADD/SLC39A2/PPP3CB/UQCRC2/RB1CC1/TUBA3D/TUBA3E/TUBA4A/MAPK9/ITPR3/PLCB4/BRAF/TUBA3C/ATP2A3/RAF1/TUBB1/FAS/MAPK3/NDUFA7/CASP3/APBB1/EIF2S1/CSNK1A1/IRS2/PSMD4/NDUFA2/HSD17B10/COX6C/NDUFC2/PIK3R1/ADRM1/CASP8/VDAC3/XBP1/CALM2/NDUFA6/PSMC6/IL1B/PSMD9/PSMC2/SLC39A6/TUBA1B/TRAF2/AMBRA1/WNT10B/NDUFS8/NDUFB1/NDUFA12/NDUFS3/BID/LRP1/FZD1/PSMA1/CAPN2/HRAS/PIK3R2/ADAM10/PSMC5/IKBKB/KIF5C/COX4I1/CYC1/SLC39A4/PSMD11/PIK3CA/MAP3K5/DKK1/SLC39A3/TNF/DDIT3/UQCR11/ITPR2/CHRM3/NDUFA9/WNT1/NDUFS4/ADAM17/ATF6/SLC25A5/CALM1/SDHB/BECN1/COX6B2/ATG2B/PLCB3/NDUFA11/KIF5B/CDK5/MME/CSNK2A2/PPID/NDUFV1/NDUFB5/NDUFAB1/IRS1/RTN3/APOE/EIF2AK3/SDHC/PSMB3/RELA/CSNK2A1/MAP2K1/ULK1/ATG2A/COX5A/PSEN2/NDUFS6/NDUFA3/NDUFB9/COX6A1/PSMD8/NFKB1/SLC39A7/PSMA4/PSMB7/PSMD14/CYBB/ULK2/WNT8A/PPP3CA/NDUFS5/COX7C/APAF1/MAP2K7/GRIN2C/WIPI1/CALML4/KLC4/SLC39A9/FZD9/SLC39A11/TUBA8/CALML5/CYCS/CACNA1F/ITPR1/EIF2AK2/KRAS/PTGS2/GRIN1/NDUFA8/TUBB6/PSMA5/IRS4/MAPK8/PSMB6/DKK2/NDUFA13/CACNA1S/CHRNA7/AGER/COX7A2L/NDUFA5/SLC39A8/CASP12/WNT4/PSMD3/PSMB2/ERN1/CALM3/PSMA8/GRIN2D/PSMC3/NOX4/KLC3/INSR/CALML3/NAE1/INS/NDUFV3/CASP7/SDHD/PPP3CC/CACNA1D/FRAT2/TUBB/BACE2/CHRM5/CAPN1/CHRM1/DVL3/WNT5B/NRBF2/CTNNB1/PLCB1/APC/AXIN1/SLC39A1/LRP6/TUBB3/FZD6/NRAS/CHUK/PIK3R3/MAPT/GRIN2A/PPP3R1/MAPK10/WNT5A/UQCRC1/FZD8/SLC39A10/NDUFB7/LPL/FZD3/SLC25A6/SLC39A5/CSF1/DKK4/KLC2/CDK5R1/VDAC1/IL6/KIF5A/FZD7/NDUFA4L2/GSK3B/IL1A	325
KEGG	hsa04724	Glutamatergic synapse	102/6408	114/8135	0.001982	0.005562	0.002139	GNG13/GRIA2/SLC17A8/SLC17A7/GNG5/PLCB2/PRKACA/GNB1/GNAQ/GNG2/PPP3R2/GRM6/PRKCB/PLA2G4D/GNG10/CACNA1C/GNAI1/GNAI3/GLS/MAPK1/GRIN2B/PLA2G4C/GNAS/PLD2/GLUL/GRM8/GNGT2/ADCY8/PPP3CB/ITPR3/PLCB4/MAPK3/GNB2/HOMER3/ADCY6/PLD1/GNB5/DLG4/JMJD7-PLA2G4B/PLA2G4B/ITPR2/ADCY4/GNAI2/SLC38A2/PLCB3/GRIK5/GRIA3/GNB3/ADCY7/GNG3/SLC1A1/GRIK1/PLA2G4F/GNAO1/GNG7/GNG11/PPP3CA/GRIN2C/ITPR1/GRM2/GRIN1/GNG8/PRKACB/SHANK2/GRM4/ADCY9/GNB4/GNGT1/SLC1A7/GNG12/ADCY3/GRIN2D/PRKACG/PRKCG/SLC38A3/PPP3CC/CACNA1D/SLC1A3/GRIA4/KCNJ3/SHANK3/SLC1A6/PLCB1/SLC17A6/GRIN3B/PRKCA/GLS2/PLA2G4A/GRM3/GRIK3/GRIN2A/PPP3R1/DLGAP1/GRIA1/ADCY1/GRIN3A/GNG4/SLC38A1/ADCY2/GRM7/GRIK4/GRIK2	102
KEGG	hsa00010	Glycolysis / Gluconeogenesis	62/6408	67/8135	0.002084	0.0058	0.00223	ALDOB/LDHAL6B/PCK1/ADH1B/ADH7/PGAM1/PGK1/TPI1/FBP1/LDHAL6A/GAPDH/ENO1/HK3/PDHA2/PGAM2/ALDH9A1/ENO3/ADH5/PGM1/DLD/AKR1A1/GALM/PGK2/PFKP/ACSS2/ALDOA/ADH1A/G6PC/PDHB/GPI/HK1/PCK2/LDHA/ALDH2/PDHA1/ALDH3B1/ALDH1B1/HKDC1/ALDOC/GCK/ENO2/ALDH7A1/PFKM/PFKL/G6PC2/ACSS1/LDHB/PKLR/ALDH3A2/G6PC3/ADPGK/HK2/ALDH3A1/GAPDHS/MINPP1/ALDH3B2/BPGM/LDHC/DLAT/PGM2/FBP2/ADH1C	62
KEGG	hsa04962	Vasopressin-regulated water reabsorption	42/6408	44/8135	0.002203	0.006081	0.002338	PRKACA/NSF/ARHGDIG/DYNLL1/DYNLL2/CREB3/ARHGDIB/DYNC1LI1/RAB5A/GNAS/ARHGDIA/DYNC1LI2/DCTN6/RAB11A/ADCY6/DYNC1H1/DCTN1/CREB5/DCTN2/STX4/DYNC1I2/RAB5B/DCTN5/VAMP2/CREB3L4/CREB3L2/DCTN4/PRKACB/RAB5C/AVP/CREB1/AVPR2/ADCY9/DYNC2LI1/ADCY3/RAB11B/PRKACG/AQP3/DYNC2H1/AQP2/DYNC1I1/CREB3L1	42
KEGG	hsa04913	Ovarian steroidogenesis	48/6408	51/8135	0.00261	0.007144	0.002747	LHCGR/BMP15/FSHR/HSD17B2/IGF1/HSD3B1/PRKACA/HSD17B1/PLA2G4D/ACOT1/ACOT2/PLA2G4C/GNAS/ADCY8/HSD17B7/ADCY6/HSD3B2/JMJD7-PLA2G4B/PLA2G4B/ADCY4/CYP2J2/CGA/LDLR/ALOX5/STAR/ADCY7/CYP11A1/PLA2G4F/BMP6/IGF1R/CYP1A1/PTGS2/PRKACB/CYP17A1/ADCY9/ADCY3/SCARB1/CYP1B1/PRKACG/INSR/INS/PLA2G4A/AKR1C3/ADCY1/FSHB/CYP19A1/ADCY2/LHB	48
KEGG	hsa04723	Retrograde endocannabinoid signaling	130/6408	148/8135	0.002875	0.007808	0.003002	GABRA6/GABRG2/GNG13/GRIA2/SLC17A8/GABRE/GABRR1/GABRA4/GABRA2/NDUFS7/SLC17A7/NDUFS1/NDUFC1/NDUFB3/NDUFA1/GNG5/NDUFS2/GABRB1/PLCB2/PRKACA/MAPK14/GNB1/GNAQ/GNG2/PRKCB/GNG10/KCNJ6/NDUFB10/NDUFA4/NDUFV2/CACNA1C/GNAI1/GNAI3/SLC32A1/NDUFB4/NDUFA10/NDUFB2/MAPK1/NDUFB11/NDUFB6/NDUFB8/GNGT2/ADCY8/MAPK9/ITPR3/PLCB4/MAPK3/GNB2/NDUFA7/NDUFA2/NDUFC2/DAGLA/NDUFA6/ADCY6/MAPK11/NDUFS8/NDUFB1/MAPK13/NDUFA12/NDUFS3/GNB5/FAAH/ITPR2/MAPK12/NDUFA9/ADCY4/NDUFS4/DAGLB/GNAI2/PLCB3/NDUFA11/NDUFV1/NDUFB5/NDUFAB1/GRIA3/GNB3/ADCY7/GNG3/KCNJ5/MGLL/GABRP/NDUFS6/NDUFA3/NDUFB9/GNAO1/GNG7/GNG11/NDUFS5/RIMS1/CACNA1F/ITPR1/PTGS2/NDUFA8/GNG8/PRKACB/MAPK8/GABRA1/NDUFA13/CACNA1S/ADCY9/GNB4/GNGT1/NDUFA5/GNG12/ADCY3/PRKACG/PRKCG/ABHD6/NDUFV3/CACNA1D/GRIA4/KCNJ3/CACNA1B/GABRA3/PLCB1/SLC17A6/GABRG1/PRKCA/GABRD/GABRA5/GABRG3/MAPK10/GRIA1/NDUFB7/GABRB3/ADCY1/GNG4/GABRR3/ADCY2/NDUFA4L2	130
KEGG	hsa01522	Endocrine resistance	88/6408	98/8135	0.0031	0.008282	0.003184	BIK/BAD/AKT2/IGF1/NCOA3/GRB2/E2F1/MDM2/PRKACA/MAPK14/PIK3CB/SHC1/SOS1/RPS6KB2/CCND1/MAP2K2/ARAF/PIK3CD/ABCB11/MAPK1/NOTCH1/SHC3/MTOR/AKT1/GNAS/AKT3/ADCY8/MAPK9/BRAF/CYP2D6/RAF1/MAPK3/PIK3R1/CDKN1A/ADCY6/MAPK11/BAX/MAPK13/HRAS/PIK3R2/NCOR1/PIK3CA/MAPK12/ADCY4/JAG2/JUN/CDKN1B/ADCY7/CDKN2C/PTK2/JAG1/MAP2K1/DLL3/ESR2/CDKN2A/IGF1R/SOS2/E2F3/MMP9/KRAS/FOS/PRKACB/MAPK8/ADCY9/MMP2/ADCY3/CARM1/PRKACG/DLL1/SRC/CDK4/MED1/RPS6KB1/TP53/RB1/ESR1/SHC2/NRAS/BCL2/NOTCH2/SHC4/PIK3R3/E2F2/HBEGF/MAPK10/ADCY1/DLL4/ADCY2	88
KEGG	hsa05231	Choline metabolism in cancer	88/6408	98/8135	0.0031	0.008282	0.003184	SLC5A7/AKT2/GRB2/RAC1/PIK3CB/RAC2/PRKCB/TSC1/PLA2G4D/SOS1/DGKD/RPS6KB2/MAP2K2/WAS/PCYT1A/PIK3CD/MAPK1/GPCPD1/MTOR/TSC2/AKT1/PLA2G4C/SLC22A2/PLD2/AKT3/PDGFRB/PIP5K1C/MAPK9/RAF1/MAPK3/RHEB/SLC44A2/PIK3R1/SLC22A4/PLD1/EIF4EBP1/HRAS/SLC44A1/PIK3R2/CHKB/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/RALGDS/DGKQ/DGKZ/JUN/MAP2K1/PLA2G4F/SOS2/PIP5K1A/HIF1A/DGKA/PCYT1B/KRAS/PDGFD/CHKA/SLC22A1/DGKE/FOS/PLCG1/MAPK8/EGF/LYPLA1/PIP5K1B/CHPT1/PDGFB/WASF3/PDGFC/DGKI/PRKCG/SLC22A3/DGKG/RPS6KB1/PDGFA/WASF2/PRKCA/NRAS/SLC22A5/PIK3R3/PLA2G4A/PDPK1/MAPK10/SLC44A4/PDGFRA/DGKH/WASF1/SLC44A3	88
KEGG	hsa04929	GnRH secretion	59/6408	64/8135	0.003439	0.009115	0.003505	KCNJ11/TRPC5/AKT2/KCNN2/PLCB2/HCN1/PIK3CB/GNAQ/PRKCB/ARRB1/KCNJ6/MAP2K2/GNA11/CACNA1C/KCNN3/PIK3CD/MAPK1/ARRB2/AKT1/AKT3/ITPR3/PLCB4/RAF1/MAPK3/GNRH1/PIK3R1/HCN2/HRAS/PIK3R2/PIK3CA/ITPR2/CGA/PLCB3/GABBR1/CACNA1H/KCNJ5/MAP2K1/ESR2/KISS1/HCN3/CACNA1F/ITPR1/KRAS/CACNA1I/CACNA1S/GABBR2/PRKCG/CACNA1D/KCNN4/KCNJ3/PLCB1/PRKCA/NRAS/KISS1R/PIK3R3/CACNA1G/SPP1/LHB/GNRH2	59
KEGG	hsa04530	Tight junction	147/6408	169/8135	0.003883	0.01013	0.003896	BVES/IGSF5/CD1B/DLG2/CLDN8/PARD6A/PPP2CA/ARHGEF2/ACTG1/TUBA1A/TUBA1C/PRKACA/RAC1/MYH9/SLC9A3R1/RHOA/PPP2R2C/ARPC4/ARPC5/MSN/HSPA4/CCND1/ARPC1A/ACTN1/CLDN1/WAS/VASP/ARPC1B/ACTR3B/ARPC2/RUNX1/CLDN3/CFTR/TUBAL3/PPP2R2D/CGN/ACTR3/EZR/MYL6B/LLGL1/PRKAB1/F11R/RAB8B/MYL6/HCLS1/TUBA3D/TUBA3E/TUBA4A/MAPK9/ARPC5L/ARPC3/TUBA3C/ROCK1/MYL12A/MYL12B/MICALL2/MPP5/CLDN5/STK11/WHAMM/TUBA1B/PPP2R2A/MAGI1/ACTB/ACTN4/TJAP1/CLDN15/PRKAG1/MAP3K5/LLGL2/RAP1A/MYH14/SYNPO/AMOT/PRKAG2/ARHGEF18/CDC42/JUN/PRKAA1/TJP3/ROCK2/PRKCZ/CLDN19/CLDN9/CLDN2/DLG1/MARVELD3/PARD3/RAP2C/PPP2R1A/MAP2K7/PPP2R2B/CLDN6/NF2/TUBA8/CLDN23/CD1D/JAM3/PRKACB/RAB13/MAPK8/PCNA/SYMPK/MYH11/CLDN4/PARD6G/PRKACG/ITGB1/TIAM1/JAM2/SRC/SCRIB/MYL9/NEDD4L/CDK4/CTTN/CACNA1D/PPP2CB/CRB3/MAP3K1/CLDN11/TJP2/CLDN7/AMOTL1/EPB41L4B/ACTR2/CLDN16/RAPGEF6/PPP2R1B/RDX/MPDZ/MAPK10/RAB8A/CD1C/PRKAG3/PARD6B/MPP4/ARHGAP17/MYH10/PRKAA2/CGNL1/RAPGEF2/NEDD4/CLDN17/PRKAB2/PRKCE/CLDN14	147
KEGG	hsa01200	Carbon metabolism	102/6408	115/8135	0.003964	0.01013	0.003896	ALDOB/TKTL2/HAO1/PRPS1L1/PGAM1/PGK1/PHGDH/SUCLG1/TPI1/FBP1/GPT/GLYCTK/GCSH/TALDO1/GAPDH/IDH3G/ACADS/ENO1/HK3/SDS/PDHA2/PGAM2/ENO3/ADH5/SDHA/DLD/PGK2/MDH1/ME2/MDH2/PFKP/ACSS2/ECHS1/ALDOA/TKT/ACOX1/IDH3B/PDHB/PCCA/CS/FH/CAT/GPI/HK1/PGP/ACO2/G6PD/SDHB/PRPS2/OGDH/PGD/PDHA1/HIBCH/HKDC1/ALDOC/PGLS/GCK/SDHC/ACAT1/ENO2/PCCB/ESD/PC/OGDHL/DLST/PFKM/SUCLA2/PFKL/MCEE/AMT/GOT1L1/ACSS1/GLUD1/ACOX3/PKLR/SHMT2/RPE/GOT1/ACAT2/GOT2/IDH2/IDH1/ADPGK/ACO1/HK2/H6PD/ME3/RGN/SDHD/GPT2/AGXT/GLUD2/PRPS1/SHMT1/DLAT/IDH3A/HAO2/RPIA/TKTL1/SDSL/FBP2/ALDH6A1	102
KEGG	hsa04216	Ferroptosis	39/6408	41/8135	0.00397	0.01013	0.003896	SAT1/FTH1/ACSL3/MAP1LC3B/ATG5/VDAC2/LPCAT3/SLC11A2/SAT2/VDAC3/MAP1LC3A/PRNP/GSS/ATG7/SLC40A1/ACSL4/GCLM/NCOA4/TFRC/MAP1LC3C/PCBP1/SLC3A2/TF/CYBB/STEAP3/ACSL1/CP/FTL/GPX4/ACSL5/SLC39A8/TP53/ALOX15/MAP1LC3B2/ACSL6/GCLC/PCBP2/HMOX1/SLC7A11	39
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	64/6408	70/8135	0.003974	0.01013	0.003896	IGSF5/PTPRZ1/ATP6V1H/PAK1/RAC1/MAPK14/ATP6V0D1/ATP6V0A1/ATP6V0E1/ATP6AP1/CXCR1/IKBKG/ATP6V1B2/ATP6V0B/ATP6V1E2/F11R/ATP6V1E1/MAPK9/ATP6V1D/CASP3/NOD1/TCIRG1/PLCG2/MAPK11/NFKBIA/MAPK13/ADAM10/IKBKB/GIT1/MAPK12/ADAM17/ATP6V1B1/CXCL1/ATP6V1F/CDC42/LYN/ATP6V1C1/JUN/MAP2K4/RELA/ATP6V0E2/ATP6V0A2/CXCR2/NFKB1/ATP6V0C/ATP6V1A/CXCL3/ATP6V0D2/JAM3/PLCG1/MAPK8/ATP6V1G3/JAM2/SRC/MAP3K14/PTPN11/CCL5/CHUK/CSK/HBEGF/ATP6V1G2/MAPK10/MET/ATP6V0A4	64
KEGG	hsa05230	Central carbon metabolism in cancer	64/6408	70/8135	0.003974	0.01013	0.003896	LDHAL6B/SLC2A2/PGAM1/AKT2/PIK3CB/LDHAL6A/MAP2K2/SIRT6/PIK3CD/HK3/PDHA2/PGAM2/GLS/MAPK1/MTOR/AKT1/AKT3/PDGFRB/PTEN/RAF1/KIT/MAPK3/PFKP/PIK3R1/RET/PDK1/PDHB/SLC16A3/HRAS/PIK3R2/PIK3CA/HK1/G6PD/SIRT3/NTRK3/LDHA/PDHA1/SLC7A5/HKDC1/GCK/MAP2K1/SCO2/NTRK1/PFKM/HIF1A/PFKL/KRAS/FGFR2/LDHB/SLC2A1/IDH2/IDH1/HK2/SLC1A5/TP53/FGFR1/FLT3/LDHC/NRAS/GLS2/PIK3R3/MET/PDGFRA/MYC	64
KEGG	hsa04623	Cytosolic DNA-sensing pathway	58/6408	63/8135	0.004054	0.01026	0.003945	IFNA2/IFNB1/IL33/IFNA1/IFNA13/ADAR/NFKBIB/RIPK1/IKBKG/RIPK3/TBK1/POLR3H/POLR3C/POLR2E/POLR2F/IL1B/PYCARD/MAVS/IRF3/NFKBIA/IKBKB/POLR2H/POLR3D/CASP1/POLR1C/IRF7/POLR3G/AIM2/RELA/TREX1/DDX58/IFNA8/POLR3F/NFKB1/POLR3E/IKBKE/POLR3GL/POLR3K/POLR2K/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/CCL4/CCL5/IL18/ZBP1/POLR1D/POLR2L/CHUK/POLR3B/POLR3A/IFNA17/IL6	58
KEGG	hsa04371	Apelin signaling pathway	122/6408	139/8135	0.004098	0.01029	0.003957	GNG13/RYR3/PLAT/PIK3C3/AKT2/GNG5/PLCB2/PRKACA/GNA13/GNB1/GNAQ/GNG2/PIK3R4/GNG10/CALML6/RPS6KB2/CCND1/MAP2K2/MAP1LC3B/PIK3R5/GNAI1/GNAI3/MYLK2/SMAD2/MAPK1/MTOR/AKT1/PRKAB1/AKT3/RPS6/GNGT2/ADCY8/SMAD4/SLC9A1/ITPR3/PLCB4/NOS3/RAF1/MAPK3/GNB2/RRAS/PLIN1/MAP1LC3A/CALM2/HDAC5/MEF2D/ADCY6/APLN/SMAD3/GNB5/HRAS/PRKAG1/ITPR2/ADCY4/PRKAG2/CALM1/BECN1/MEF2A/GNAI2/PLCB3/HDAC4/PRKAA1/GNB3/TFAM/ADCY7/GNG3/JAG1/MAP2K1/AGTR1/MAP1LC3C/NRF1/GNG7/GNG11/MYLK3/CALML4/CALML5/ITPR1/MEF2C/KRAS/GNG8/PRKACB/ACTA2/RYR1/SERPINE1/SLC8A3/ADCY9/TGFBR1/UCP1/GNB4/GNGT1/GNG12/ADCY3/MYLK/CALM3/PRKACG/SLC8A1/CALML3/PIK3CG/PIK3R6/RPS6KB1/SPHK2/MAP1LC3B2/MYL4/PLCB1/NRAS/PDE3B/MYL3/SPHK1/KLF2/APLNR/MRAS/ADCY1/PRKAG3/GNG4/RYR2/PRKAA2/CAMK4/ADCY2/PRKAB2/SPP1/PRKCE/RRAS2	122
KEGG	hsa03013	Nucleocytoplasmic transport	96/6408	108/8135	0.004404	0.01097	0.004217	UPF1/CASC3/UBE2I/RAE1/RAN/NUP214/RNPS1/NXF1/IPO8/XPO6/NUP98/IPO4/KPNB1/SEC13/NUP188/AHCTF1/RBM8A/EIF4A3/CSE1L/NCBP1/NUP85/UPF2/NXT2/XPOT/NUP50/RANBP2/POM121/POM121C/XPO1/THOC5/NUP62/EEF1A1/MAGOH/SENP2/KPNA2/NUP37/IPO11/KPNA6/NUP133/ACIN1/DDX19A/DDX19B/GLE1/UPF3A/NUP93/SUMO1/SUMO3/XPO5/NUP205/TMEM33/IPO13/MAGOHB/TNPO3/RANBP17/TPR/THOC7/SNUPN/NUP155/NUP153/NXF2/NXF2B/EEF1A2/THOC3/NXT1/TNPO1/NUP88/RANGAP1/THOC2/KPNA1/PHAX/SUMO2/NUP35/SUMO4/NUP43/NUP107/SAP18/XPO7/NUP210/IPO7/AAAS/KPNA5/XPO4/NUP160/NMD3/NCBP2/TNPO2/SRRM1/KPNA4/IPO9/POM121L2/THOC1/PNN/KPNA3/THOC6/NUP54/UPF3B	96
KEGG	hsa04971	Gastric acid secretion	69/6408	76/8135	0.004433	0.01097	0.004217	ACTG1/CAMK2G/KCNK2/KCNK10/PLCB2/PRKACA/GNAQ/PRKCB/CALML6/ATP4B/GNAI1/GNAI3/HRH2/MYLK2/CFTR/EZR/GNAS/ATP1B3/KCNJ15/ADCY8/SLC9A1/ITPR3/PLCB4/SLC4A2/KCNQ1/CALM2/ADCY6/ACTB/ITPR2/CHRM3/ADCY4/CALM1/GNAI2/PLCB3/KCNJ2/ADCY7/CAMK2B/KCNJ1/GAST/MYLK3/CALML4/CALML5/ITPR1/PRKACB/SST/ADCY9/KCNE2/ATP1A1/ADCY3/MYLK/CALM3/PRKACG/CALML3/CAMK2D/PRKCG/CCKBR/CAMK2A/CA2/PLCB1/PRKCA/KCNJ10/SLC26A7/ADCY1/ATP1A4/ADCY2/KCNJ16/ATP1A3/ATP4A/ATP1A2	69
KEGG	hsa04670	Leukocyte transendothelial migration	101/6408	114/8135	0.004503	0.01106	0.004252	CDH5/RASSF5/CLDN8/PTK2B/ITGB2/ACTG1/RAC1/MAPK14/PIK3CB/RHOA/PXN/CTNNA1/VCL/RAC2/PRKCB/VAV1/MSN/ACTN1/CLDN1/GNAI1/GNAI3/NCF4/ITGAM/VASP/NCF1/PIK3CD/CLDN3/NCF2/EZR/F11R/ITGAL/SIPA1/ROCK1/MYL12A/MYL12B/CD99/PLCG2/BCAR1/CLDN5/PIK3R1/MAPK11/MYLPF/ACTB/MAPK13/ACTN4/PIK3R2/CLDN15/PIK3CA/RAP1A/MAPK12/VAV2/GNAI2/ESAM/ICAM1/CD99L2/CDC42/MYL10/ROCK2/CXCR4/CLDN19/PTK2/CYBA/CLDN9/CLDN2/CYBB/RAP1B/PECAM1/ARHGAP5/CLDN6/MMP9/CLDN23/JAM3/ITGA4/PLCG1/CLDN4/MMP2/ITGB1/JAM2/PTPN11/PRKCG/MYL9/CLDN11/RAPGEF4/CLDN7/CTNNA2/CTNNA3/THY1/ITK/CTNNB1/MYL7/PRKCA/CLDN16/PIK3R3/RHOH/RAPGEF3/VCAM1/CTNND1/MYL5/CLDN17/CXCL12/CLDN14	101
KEGG	hsa05131	Shigellosis	211/6408	247/8135	0.004543	0.01108	0.004259	IFNB1/PIK3C3/FNBP1/PLCD1/CYTH1/AKT2/TLN1/ARHGEF2/DIAPH1/ACTG1/MDM2/PLCB2/RAC1/MAPK14/PIK3CB/ITGA5/RHOA/RRAGA/ARPC4/NFKBIB/ARPC5/RRAGD/RPTOR/PIK3R4/PXN/VCL/TNIP1/WIPI2/ILK/CALCOCO2/MYD88/UBC/NLRC4/RIPK1/RPS6KB2/ARPC1A/ACTN1/IKBKG/U2AF1/MAP1LC3B/ATG5/FOXO6/ARPC1B/ACTR3B/TBK1/ARPC2/PIK3CD/HK3/ELMO2/TNFRSF1A/MAPK1/GSK3A/CASP4/ACTR3/MTOR/AKT1/AKT1S1/WASL/TRADD/CYTH4/AKT3/ATG12/ARF1/CAPNS1/SQSTM1/CRKL/HCLS1/MAPK9/ITPR3/ARPC5L/PLCB4/ARPC3/RBCK1/UBE2V1/MAPK3/ROCK1/NOD1/MYL12A/MYL12B/PLCG2/BCAR1/PIK3R1/MAP1LC3A/IL1B/CD14/TRAF6/MAPK11/PYCARD/CBX3/RRAGC/MYLPF/TRAF2/TIFA/IRF3/UBE2D2/NFKBIA/BAX/ACTB/MAPK13/CAPN2/ACTN4/PIK3R2/BCL2L1/IKBKB/UBE2D1/PIK3CA/TLR5/TAB2/HK1/TNF/UBA52/ITPR2/MAPK12/RNF31/PFN4/CASP1/BECN1/ARF6/CDC42/PLCB3/NAIP/TLN2/PPID/MYL10/JUN/BTRC/MALT1/ROCK2/HKDC1/MAP3K7/PTK2/RELA/PFN1/CUL1/TAB1/C3/MAP1LC3C/PLCD3/TAB3/RRAGB/CSF2/UBE2NL/TECPR1/ATM/RIPK2/NLRP3/CYTH3/NFKB1/PRKCD/CRK/U2AF1L4/PRKCQ/PLCZ1/WIPI1/BNIP3/CAST/UBE2N/FOXO4/SKP1/FOXO1/CYCS/ITPR1/FBXW11/RBX1/ELMO1/PLCG1/MAPK8/CD44/PLCD4/BCL10/CYTH2/ITGB1/UBE2D3/SRC/HK2/GLMN/UBE2V2/CCL5/MYL9/RPS6KA5/CTTN/RPS6KB1/TP53/UBE2D4/SHARPIN/IL18/MAP1LC3B2/CAPN1/ACTR2/TRAF5/PLCB1/MYL7/WASF2/FOXO3/BCL2/CHUK/PIK3R3/DOCK1/PLCE1/MAPK10/RPS27A/PFN2/IL1R1/TLR4/MYL5/FNBP1L/VDAC1/UBB/GSK3B/WASF1/PRKCE	211
KEGG	hsa03320	PPAR signaling pathway	68/6408	75/8135	0.005152	0.01243	0.004778	ADIPOQ/CYP7A1/PCK1/SLC27A4/ACAA1/PPARA/DBI/FADS2/PLTP/ILK/UBC/ACSL3/CPT1C/RXRA/ANGPTL4/PLIN5/CPT2/PLIN1/ACSBG2/ACOX1/FABP2/AQP7/CPT1B/HMGCS1/PCK2/CD36/ACSL4/SLC27A5/APOA1/CPT1A/RXRB/ACADL/SLC27A1/GK2/HMGCS2/PLIN2/NR1H3/SLC27A2/CYP8B1/PLIN4/ACSL1/SORBS1/ACOX3/ACSL5/ACSBG1/PPARD/UCP1/CYP27A1/FABP5/GK/FABP3/ME3/ACSL6/SCD5/ACADM/APOA5/MMP1/APOC3/SCD/PDPK1/FABP6/LPL/FABP7/ACOX2/SCP2/RXRG/PPARG/EHHADH	68
KEGG	hsa04060	Cytokine-cytokine receptor interaction	250/6408	295/8135	0.005206	0.01243	0.004778	IL12A/BMP15/IFNA2/IFNB1/IL13RA2/IL33/MSTN/TSLP/IL2/CNTF/CCL25/TNFSF15/TNFRSF6B/IFNA1/IFNA13/GHR/RELT/IFNE/XCR1/GDF10/ACVRL1/IFNGR2/TNFRSF14/CD40/IL17RA/TNFSF9/IL10RA/CD70/IL2RG/IL20/TNFRSF1B/BMP3/EDA/IL16/CCL14/CCL15/CXCR1/EPOR/LTBR/IL31RA/TNFRSF10C/CXCL16/TGFB1/IL22RA1/TGFB2/TNFRSF10D/IL27RA/IFNAR1/EBI3/LTB/TNFRSF1A/TNFSF12/TNFRSF8/TNFRSF12A/CD4/IL6R/IL13RA1/BMP8A/IL17A/CSF3R/FAS/IL22/IL10/TNFRSF19/CCR1/IL12RB1/IL2RA/IL1B/CSF1R/LIFR/IFNGR1/TNFSF13/CSF2RB/TNFRSF10B/AMH/IL34/IL23A/GDF1/ACVR2B/BMP7/IL4R/CXCR3/TNF/IL1RN/IL12RB2/IL1F10/CCR2/IL25/CCL28/CXCL1/IL11RA/IL6ST/TNFSF10/GDF9/IL10RB/CXCR4/CCL24/IL1RL1/IL20RA/TNFRSF11B/CRLF2/TNFRSF13B/INHBB/CCL19/CSF2/IFNA8/BMP6/CXCR2/IL18RAP/IL1R2/AMHR2/ACVR1/CXCL3/TGFBR2/OSM/IL21R/TNFSF13B/ACVR1B/TNFRSF25/GDF15/IL3/TNFRSF4/CSF3/CCL27/GDF11/IL9R/IL4/LEP/CSF2RA/TNFRSF10A/IL21/IL19/CX3CR1/CXCL13/CCL26/LTA/TGFBR1/CLCF1/IL32/CCL21/GDF5/EDA2R/IL12B/CD40LG/TNFSF8/IFNAR2/IL3RA/IL13/INHBE/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/TNFSF14/IFNA16/IL20RB/IL17D/LIF/GDF2/PRLR/MPL/CCL4/TNFRSF9/CCL5/CCL1/IL17RC/CXCR5/EDAR/CCR7/CNTFR/GDF3/IL18/PPBP/IL18R1/CCL7/IL7R/EPO/CCL23/IL17C/BMPR2/CXCL11/TNFSF18/IL2RB/CCL18/BMPR1B/TNFSF4/FASLG/NODAL/IL1RL2/IL15/CCR10/CXCR6/IFNG/CCL20/CCL16/CXCL6/IL5RA/TNFRSF21/CCL13/GH1/GH2/CCL2/IL1R1/IL9/TNFRSF18/CTF1/IL17RE/THPO/ACVR2A/IL23R/PF4V1/IL15RA/INHBC/XCL1/XCL2/LEPR/BMPR1A/CCL17/IFNW1/IFNA17/BMP5/BMP8B/CSF1/CD27/OSMR/CXCL14/CCR4/CCL3/CCL3L1/CCL3L3/CXCL5/IL7/CCL11/PF4/IL24/IL6/CSH1/CXCL12/IL17B/IL17F/IL17RB/CCR6/IL1A/INHBA/IL1RAP/NGF/TNFRSF13C	250
KEGG	hsa00900	Terpenoid backbone biosynthesis	22/6408	22/8135	0.005208	0.01243	0.004778	FNTA/HMGCR/ICMT/FDPS/PDSS1/MVD/IDI1/RCE1/GGPS1/PMVK/HMGCS1/DHDDS/ACAT1/HMGCS2/IDI2/FNTB/PDSS2/ACAT2/ZMPSTE24/NUS1/PCYOX1/MVK	22
KEGG	hsa03420	Nucleotide excision repair	44/6408	47/8135	0.005416	0.01278	0.004914	GTF2H1/ERCC3/XPC/XPA/CCNH/POLD3/ERCC1/GTF2H2/GTF2H2C/CDK7/POLE4/ERCC5/DDB2/RAD23B/RFC2/POLE3/CUL4B/DDB1/CETN2/RFC3/LIG1/ERCC6/GTF2H5/POLD2/RFC5/RPA3/ERCC4/RFC1/ERCC2/POLD1/POLE/CUL4A/RBX1/RPA1/PCNA/ERCC8/POLD4/RPA2/MNAT1/GTF2H3/GTF2H4/POLE2/RFC4/RAD23A	44
KEGG	hsa04664	Fc epsilon RI signaling pathway	62/6408	68/8135	0.005433	0.01278	0.004914	AKT2/GRB2/RAC1/MAPK14/PIK3CB/BTK/SYK/RAC2/VAV1/PLA2G4D/SOS1/MAP2K2/INPP5D/PIK3CD/MAPK1/AKT1/PLA2G4C/LCP2/AKT3/MAPK9/RAF1/MAPK3/FYN/PLCG2/PIK3R1/MAPK11/MAPK13/HRAS/PIK3R2/FCER1G/JMJD7-PLA2G4B/PLA2G4B/PIK3CA/TNF/MAPK12/VAV2/LYN/GAB2/ALOX5AP/MAP2K4/ALOX5/MAP2K6/LAT/MAP2K1/PLA2G4F/CSF2/SOS2/MAP2K7/IL3/KRAS/IL4/PLCG1/MAPK8/IL13/MAP2K3/PRKCA/NRAS/PIK3R3/PLA2G4A/FCER1A/PDPK1/MAPK10	62
KEGG	hsa00052	Galactose metabolism	30/6408	31/8135	0.005668	0.01324	0.00509	SI/B4GALT2/B4GALT1/HK3/GLB1/PGM1/GALM/PFKP/UGP2/GLA/GALE/G6PC/GALK1/HK1/GAA/MGAM/HKDC1/GCK/GALT/PFKM/PFKL/G6PC2/G6PC3/AKR1B1/HK2/LALBA/AKR1B10/GANC/LCT/PGM2	30
KEGG	hsa04080	Neuroactive ligand-receptor interaction	297/6408	353/8135	0.005849	0.01357	0.005216	LHCGR/FSHR/GABRA6/GABRG2/GALP/GPR50/GRIA2/GRPR/HTR1D/MAS1/NMBR/NMUR2/NPBWR2/PATE2/PTH/TAAR1/VIP/TAC1/TRH/GABRE/GCG/GABRR1/NPY1R/HTR2C/CHRM2/CHRNA9/DRD5/TAAR9/TAAR2/GABRA4/GABRA2/MC4R/NPFFR2/GHR/P2RY4/GPR83/ADRA1D/HRH1/PTAFR/ADORA2A/GABRB1/ADM/GLP2R/MCHR2/CHRNA4/CRHR1/CHRNB4/GHRH/NPFF/GRM6/OPRK1/RXFP2/GPR35/THRB/RXFP3/CHRNA10/ADRA2B/CRH/PTGER4/NTSR2/CALCB/PRLHR/LPAR2/HRH2/CALCR/CHRNB2/TACR3/P2RX3/GCGR/ADORA2B/GRIN2B/ADRA1A/MC2R/F2RL3/GRM8/S1PR4/ADM2/GNRH1/LPAR4/OXTR/HTR6/GLP1R/MC3R/UCN3/APLN/GHRL/CHRNA3/CHRND/FPR1/PTGER2/LTB4R2/PTGFR/GPHA2/AGTR2/CHRM3/HTR2A/P2RY13/PLG/F2R/CGA/C5AR1/GLRA1/CHRM4/SSTR5/GABBR1/GRIK5/P2RX4/GRIA3/NMUR1/CALCA/HTR2B/ADORA3/P2RY6/DRD1/CHRNB3/GRIK1/GABRP/GAL/TRPV1/F2RL1/CHRNA5/LPAR6/AGTR1/C3/CHRNE/MTNR1B/SSTR3/KISS1/RXFP1/UCN/LPAR1/PARD3/INSL3/HTR7/HCRTR1/PRLH/MC1R/P2RX7/GRIN2C/TAAR8/OPRL1/P2RY8/C5/VIPR2/P2RX6/ADCYAP1R1/PTH1R/TSPO/EDN1/GRID2/POMC/P2RX1/CHRNA2/GRM2/GRIN1/C3AR1/LEP/ADORA1/VIPR1/SST/HTR5A/TBXA2R/LTB4R/AVP/GABRA1/GRM4/BRS3/CHRNA7/AVPR2/UCN2/LYPD6B/THRA/ADRA2C/KNG1/HCRT/GRIN2D/HTR1F/ADRB2/P2RY2/GALR2/PRLR/GLRA3/GABBR2/PTGIR/GPHB5/P2RY14/SSTR1/DRD2/PATE1/F2RL2/P2RY11/TACR2/CCKBR/MC5R/NPFFR1/S1PR2/HRH3/GRIA4/CALCRL/CHRM5/CHRM1/CYSLTR1/AVPR1A/GABRA3/SCT/DRD3/GHSR/PYY/MCHR1/MLNR/NPB/TAC4/HTR1A/TACR1/HTR1B/UTS2R/EDNRA/TRHR/GABRG1/GRIN3B/PPY/KISS1R/NR3C1/CRHR2/PRSS2/PRSS3/HTR1E/CNR2/MTNR1A/GRM3/GRIK3/GABRD/DRD4/PTH2R/IAPP/GABRA5/APLNR/GRP/GABRG3/GRIN2A/ADRB1/S1PR3/GH1/GH2/GALR1/NPY5R/TSHB/OPRM1/SLURP1/GRIA1/EDNRB/S1PR1/SSTR4/OPRD1/GABRB3/LEPR/GRIN3A/NMB/PTGER1/F2/FSHB/PTH2/HCRTR2/CHRNA1/PTGER3/SCTR/ADRA2A/RLN2/GNRHR/CCK/EDN2/BDKRB2/ADCYAP1/S1PR5/OXT/GABRR3/NPBWR1/CTSG/LYNX1/GPR156/CSH1/CORT/TSHR/BDKRB1/FPR3/PDYN/TAAR5/GZMA/P2RX5/LHB/GRM7/GNRH2/GRIK4/PTGDR/RLN3/PRSS1/GRIK2	297
KEGG	hsa05012	Parkinson disease	226/6408	266/8135	0.005971	0.01375	0.005288	SLC25A31/RYR3/COX6A2/COX8C/SLC39A12/COX7B2/COX4I2/PSMD6/NDUFS7/UQCRB/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/ADORA2A/NDUFB3/NDUFA1/PSMA6/NDUFS2/CAMK2G/TUBA1A/PSMA3/CASP9/TUBA1C/UBA1/PSMA7/ATF4/PRKACA/PARK7/HTRA2/PSMB1/PSMC1/PSMC4/COX6B1/COX8A/UBE2G1/HSPA5/UBE2J2/UBC/CALML6/NDUFB10/PSMD1/KLC1/NDUFA4/NDUFV2/GNAI1/SLC25A4/GNAI3/UQCRFS1/VDAC2/SLC39A13/NDUFB4/NDUFA10/NDUFB2/UQCR10/PSMA2/PINK1/PSMD12/PSMB5/NDUFB11/TUBAL3/SLC11A2/GPR37/UQCRH/GNAS/PSMD2/DAXX/PSMD13/COX7B/KEAP1/TXN/SDHA/COX7A2/NDUFB6/PSMD7/NDUFB8/PPIF/SLC39A2/UQCRC2/TUBA3D/TUBA3E/TUBA4A/MAPK9/ITPR3/TUBA3C/TUBB1/NDUFA7/CASP3/EIF2S1/PSMD4/UBA7/NDUFA2/COX6C/UBE2J1/NDUFC2/ADRM1/UBE2L3/VDAC3/MFN2/XBP1/CALM2/NDUFA6/PSMC6/PSMD9/PSMC2/SLC39A6/SOD1/TUBA1B/NDUFS8/NDUFB1/BAX/NDUFA12/NDUFS3/PSMA1/BCL2L1/PSMC5/KIF5C/COX4I1/CYC1/SLC39A4/PSMD11/MAP3K5/SLC39A3/UBA52/DDIT3/UQCR11/ITPR2/NDUFA9/NDUFS4/ATF6/SLC25A5/CALM1/SDHB/COX6B2/GNAI2/NDUFA11/KIF5B/NDUFV1/NDUFB5/NDUFAB1/EIF2AK3/DRD1/SDHC/PSMB3/UBE2L6/CAMK2B/COX5A/NDUFS6/NDUFA3/NDUFB9/COX6A1/PSMD8/TXN2/SLC39A7/PSMA4/NFE2L2/PSMB7/DUSP1/PSMD14/NDUFS5/COX7C/APAF1/CALML4/KLC4/MAOA/SLC39A9/SLC39A11/TUBA8/CALML5/CYCS/ITPR1/TRAP1/NDUFA8/TUBB6/PSMA5/PRKACB/PLCG1/MAPK8/PSMB6/NDUFA13/LRRK2/COX7A2L/NDUFA5/SLC39A8/PSMD3/PSMB2/ERN1/CALM3/PSMA8/PRKACG/PSMC3/KLC3/CALML3/CAMK2D/NDUFV3/DRD2/TP53/SDHD/CAMK2A/TUBB/SLC18A2/MFN1/UBE2G2/TH/SLC39A1/TUBB3/MAPT/MAPK10/RPS27A/SLC18A1/UQCRC1/SLC39A10/MAOB/NDUFB7/SLC25A6/SLC39A5/SNCAIP/SLC6A3/KLC2/VDAC1/KIF5A/NDUFA4L2/UBB/GNAL/UCHL1	226
KEGG	hsa04930	Type II diabetes mellitus	43/6408	46/8135	0.006482	0.01483	0.005701	KCNJ11/ADIPOQ/SLC2A2/PIK3CB/CACNA1C/PIK3CD/HK3/MAPK1/MTOR/MAPK9/MAPK3/ABCC8/IRS2/PIK3R1/PIK3R2/IKBKB/PIK3CA/HK1/TNF/IRS1/HKDC1/GCK/PRKCZ/PRKCD/PKLR/IRS4/MAPK8/CACNA1E/PDX1/SOCS3/SOCS1/SOCS4/INSR/HK2/INS/CACNA1D/CACNA1B/SOCS2/PIK3R3/MAPK10/CACNA1G/SLC2A4/PRKCE	43
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	49/6408	53/8135	0.006681	0.01518	0.005837	PTH/PLCB2/PRKACA/GNAQ/PRKCB/CLTC/CALB1/GNAS/ATP1B3/PLCB4/AP2A2/KLK1/VDR/RAB11A/ADCY6/ATP2B2/CLTCL1/ATP2B1/AP2M1/PLCB3/CLTA/DNM1/CLTB/DNM2/TRPV5/ATP2B3/PTH1R/ATP2B4/PRKACB/FXYD2/SLC8A3/ADCY9/ATP1A1/AP2S1/KLK2/PRKACG/AP2A1/SLC8A1/AP2B1/PRKCG/ESR1/PLCB1/PRKCA/KL/BDKRB2/ATP1A4/ATP1A3/DNM3/ATP1A2	49
KEGG	hsa05210	Colorectal cancer	77/6408	86/8135	0.006773	0.01528	0.005877	DCC/BCL2L11/BAD/AKT2/GRB2/CASP9/RAC1/GADD45B/PIK3CB/RHOA/RAC2/SOS1/RPS6KB2/MSH3/CCND1/MAP2K2/TGFB1/TGFB2/ARAF/PIK3CD/APC2/SMAD2/MAPK1/MTOR/AKT1/AKT3/SMAD4/MAPK9/BRAF/RAF1/MAPK3/CASP3/PIK3R1/CDKN1A/DDB2/MSH6/BAK1/SMAD3/BAX/BBC3/RALA/HRAS/PIK3R2/MLH1/PIK3CA/RALGDS/POLK/TCF7/JUN/MAP2K1/SOS2/RALB/GADD45A/TCF7L2/TGFBR2/GADD45G/CYCS/KRAS/FOS/MAPK8/EGF/TGFBR1/APPL1/TGFA/RPS6KB1/TP53/PMAIP1/CTNNB1/APC/MSH2/AXIN1/NRAS/BCL2/PIK3R3/MAPK10/MYC/GSK3B	77
KEGG	hsa01524	Platinum drug resistance	66/6408	73/8135	0.006934	0.01544	0.005937	BAD/AKT2/ATP7A/CASP9/MDM2/PIK3CB/MSH3/MGST3/POLH/XPA/PIK3CD/GSTA3/MAPK1/SLC31A1/AKT1/AKT3/ERCC1/FADD/FAS/MAPK3/CASP3/PIK3R1/CASP8/CDKN1A/MSH6/GSTO1/BAK1/BAX/BIRC2/BBC3/BID/PIK3R2/MLH1/BCL2L1/PIK3CA/MAP3K5/XIAP/GSTT1/BRCA1/CDKN2A/ATM/APAF1/CYCS/TOP2A/TOP2B/ABCC2/GSTO2/MGST1/GSTP1/GSTT2/TP53/PMAIP1/GSTM3/BIRC3/GSTM4/MGST2/GSTM1/MSH2/BCL2/FASLG/GSTM2/PIK3R3/PDPK1/GSTA1/REV3L/GSTM5	66
KEGG	hsa04115	p53 signaling pathway	66/6408	73/8135	0.006934	0.01544	0.005937	SERPINB5/IGF1/CASP9/MDM2/GADD45B/SHISA5/CCND1/SFN/TSC2/SIVA1/PTEN/FAS/RCHY1/CASP3/CCND3/CD82/CASP8/CDKN1A/DDB2/CDK1/THBS1/BAX/TNFRSF10B/BBC3/BID/BCL2L1/CCNG1/PPM1D/ATR/SESN1/SESN2/GORAB/ZMAT3/CDKN2A/ATM/TP53I3/MDM4/GADD45A/AIFM2/APAF1/CHEK2/STEAP3/GADD45G/CCND2/RRM2B/GTSE1/CYCS/CDK2/TNFRSF10A/CCNG2/SERPINE1/CCNE2/CCNE1/CDK4/TP53/PMAIP1/TP53AIP1/RRM2/PERP/BCL2/CDK6/EI24/SIAH1/CCNB2/IGFBP3/SESN3	66
KEGG	hsa00020	Citrate cycle (TCA cycle)	29/6408	30/8135	0.006995	0.01547	0.005949	PCK1/SUCLG1/IDH3G/ACLY/PDHA2/SDHA/DLD/MDH1/MDH2/IDH3B/PDHB/CS/FH/ACO2/PCK2/SDHB/OGDH/PDHA1/SDHC/PC/OGDHL/DLST/SUCLA2/IDH2/IDH1/ACO1/SDHD/DLAT/IDH3A	29
KEGG	hsa04270	Vascular smooth muscle contraction	117/6408	134/8135	0.007294	0.01603	0.006163	RAMP2/KCNMB2/KCNU1/PLA2G2D/ADRA1D/ADORA2A/ADM/RAMP1/PLCB2/PRKACA/GNA13/MYH9/RHOA/GNAQ/NPPA/ARHGEF1/PRKCB/PLA2G4D/CALML6/MAP2K2/CALCB/GNA11/CACNA1C/ARAF/MYLK2/MAPK1/ADORA2B/MYL6B/PLA2G4C/GNAS/ADRA1A/MYL6/ACTG2/NPR1/ADCY8/ADM2/ITPR3/PLCB4/BRAF/RAF1/MAPK3/ROCK1/CALM2/ARHGEF11/ADCY6/PLA2G6/PPP1R12A/JMJD7-PLA2G4B/PLA2G4B/GUCY1A2/MYH14/ITPR2/ADCY4/CALM1/PLCB3/PLA2G12A/CALCA/ROCK2/MRVI1/ADCY7/PRKCH/MAP2K1/PPP1R12C/AGTR1/PPP1CA/PLA2G4F/PRKCD/MYLK3/KCNMB3/PRKCQ/CALML4/PLA2G2A/EDN1/CALML5/CACNA1F/ITPR1/NPR2/PPP1R12B/PRKACB/AVP/ACTA2/CACNA1S/GNA12/MYH11/ADCY9/RAMP3/ADCY3/MYLK/PPP1R14A/CALM3/PRKACG/CALML3/PTGIR/PRKCG/PPP1CC/MYL9/CACNA1D/CALCRL/KCNMB1/AVPR1A/PPP1CB/PLCB1/EDNRA/NPPC/PRKCA/PLA2G4A/CALD1/PLA2G2F/ADCY1/MYH10/EDN2/PRKG1/ADCY2/NPPB/PLA2G1B/PRKCE/PLA2G12B	117
KEGG	hsa04012	ErbB signaling pathway	76/6408	85/8135	0.007769	0.01696	0.006521	PAK1/BAD/AKT2/GRB2/CAMK2G/BTC/PIK3CB/SHC1/NCK2/STAT5B/PRKCB/SOS1/RPS6KB2/MAP2K2/STAT5A/ARAF/PIK3CD/MAPK1/SHC3/MTOR/AKT1/AKT3/ELK1/CRKL/MAPK9/BRAF/RAF1/MAPK3/PLCG2/PIK3R1/CDKN1A/EIF4EBP1/HRAS/PIK3R2/PIK3CA/ABL2/NCK1/JUN/MAP2K4/CDKN1B/PAK2/PTK2/MAP2K1/CAMK2B/CBLB/SOS2/ABL1/CRK/MAP2K7/PAK4/KRAS/PLCG1/MAPK8/EGF/CBL/SRC/CAMK2D/PRKCG/TGFA/RPS6KB1/CAMK2A/NRG1/ERBB3/ERBB4/SHC2/PRKCA/NRAS/SHC4/PIK3R3/HBEGF/GAB1/PAK3/MAPK10/PAK6/MYC/GSK3B	76
KEGG	hsa05225	Hepatocellular carcinoma	145/6408	168/8135	0.007907	0.01715	0.006593	FZD10/WNT2/WNT9B/BAD/AKT2/ACTG1/GRB2/E2F1/GADD45B/FZD2/PIK3CB/SHC1/WNT3/LRP5/WNT7B/DVL1/PRKCB/SOS1/RPS6KB2/CCND1/SMARCD1/MAP2K2/WNT7A/MGST3/WNT8B/FRAT1/DVL2/TGFB1/TGFB2/ARAF/PIK3CD/APC2/SMAD2/GSTA3/MAPK1/SMARCC1/TXNRD1/SHC3/MTOR/AKT1/AKT3/ELK1/KEAP1/WNT16/PTEN/SMAD4/BRAF/RAF1/MAPK3/TXNRD2/CSNK1A1/PLCG2/PIK3R1/SMARCD3/CDKN1A/DDB2/GSTO1/WNT10B/BAK1/NQO1/SMAD3/BAX/ACTB/FZD1/HRAS/PIK3R2/BCL2L1/PIK3CA/WNT1/PHF10/POLK/BRD7/SMARCA4/TCF7/SMARCD2/DPF1/TERT/GSTT1/MAP2K1/HGF/CDKN2A/NFE2L2/IGF1R/SOS2/ARID1A/WNT8A/E2F3/GADD45A/SMARCB1/TCF7L2/PBRM1/TGFBR2/GADD45G/FZD9/KRAS/PLCG1/GSTO2/TGFBR1/ARID2/SMARCE1/WNT4/MGST1/GSTP1/PRKCG/TGFA/CDK4/GSTT2/RPS6KB1/TP53/RB1/FRAT2/GSTM3/DVL3/GSTM4/WNT5B/MGST2/GSTM1/CTNNB1/ACTL6A/APC/SMARCA2/AXIN1/LRP6/SHC2/FZD6/PRKCA/NRAS/CDK6/GSTM2/SHC4/PIK3R3/E2F2/GAB1/IGF2/WNT5A/FZD8/GSTA1/FZD3/HMOX1/MET/GSTM5/FZD7/DPF3/MYC/GSK3B	145
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	20/6408	20/8135	0.008405	0.01811	0.006964	CHSY3/CHST3/CHST13/B4GALT7/UST/B3GAT3/CHSY1/XYLT2/CHST15/CHPF/CHST7/CHST11/DSE/B3GALT6/CHST12/CHST14/CSGALNACT2/CHPF2/XYLT1/CSGALNACT1	20
KEGG	hsa01250	Biosynthesis of nucleotide sugars	35/6408	37/8135	0.008579	0.01825	0.007017	MPI/NANS/HK3/PMM1/PGM1/GMDS/CMAS/NAGK/UGP2/GMPPA/GALE/GMPPB/GALK1/GPI/HK1/GNPNAT1/PMM2/UXS1/HKDC1/GCK/GALT/GFPT2/NANP/PGM3/TSTA3/FPGT/GFPT1/UAP1L1/GALK2/HK2/MIOX/UAP1/GNE/PGM2/TGDS	35
KEGG	hsa05143	African trypanosomiasis	35/6408	37/8135	0.008579	0.01825	0.007017	IL12A/PLCB2/GNAQ/NPPA/PRKCB/MYD88/TLR9/PLCB4/FAS/IL10/IL1B/TNF/APOL1/ICAM1/PLCB3/APOA1/F2RL1/HBB/SELE/HPR/IL12B/KNG1/PRKCG/IL18/PLCB1/PRKCA/FASLG/IFNG/IDO1/VCAM1/LAMA4/THOP1/IL6/HBA1/HBA2	35
KEGG	hsa04934	Cushing syndrome	134/6408	155/8135	0.009274	0.0196	0.007538	FZD10/WNT2/WNT9B/HSD3B1/PDE8A/CAMK2G/KCNK2/E2F1/PLCB2/ATF4/PRKACA/FZD2/CRHR1/WDR5B/GNAQ/WNT3/CREB3/NCEH1/WNT7B/DVL1/AIP/CCND1/MAP2K2/CRH/WNT7A/AIPL1/GNA11/CACNA1C/GNAI1/WNT8B/GNAI3/DVL2/APC2/MAPK1/ARMC5/GNAS/MC2R/WNT16/ATF6B/ADCY8/ITPR3/PLCB4/BRAF/MAPK3/USP8/CDKN1A/ADCY6/CREB5/WNT10B/HSD3B2/FZD1/FH/RAP1A/ITPR2/WNT1/ADCY4/RASD1/PDE11A/GNAI2/PLCB3/MEN1/TCF7/CDKN1B/LDLR/CACNA1H/STAR/ADCY7/CDKN2C/ASH2L/CYP11A1/MAP2K1/ORAI1/CAMK2B/AGTR1/CDKN2A/WNT8A/RAP1B/E2F3/CYP21A2/CDKN2B/TCF7L2/WDR5/FZD9/ATF2/NR4A1/CACNA1F/ITPR1/POMC/CDK2/CREB3L4/CREB3L2/PRKACB/CYP17A1/CACNA1I/CACNA1S/CREB1/ADCY9/ADCY3/CCNE2/SCARB1/WNT4/PRKACG/CCNE1/CAMK2D/KCNK3/CDK4/RB1/CACNA1D/CAMK2A/DVL3/WNT5B/PBX1/CTNNB1/PLCB1/APC/AHR/AXIN1/ARNT/FZD6/CDK6/CRHR2/E2F2/RBBP5/CYP11B1/WNT5A/FZD8/CACNA1G/FZD3/ADCY1/PDE8B/ADCY2/CREB3L1/FZD7/GSK3B	134
KEGG	hsa05150	Staphylococcus aureus infection	85/6408	96/8135	0.009342	0.01962	0.007545	KRT13/MBL2/KRT12/KRT20/KRT34/KRT27/PTAFR/ITGB2/C1R/SELPLG/ITGAM/FCGR2A/ITGAL/KRT32/CFI/IL10/C2/KRT33B/KRT24/FPR1/PLG/ICAM1/C5AR1/SELP/KRT19/HLA-DMB/C1QB/FCGR3B/FCGR2C/C3/CFB/CAMP/FCGR1A/C5/C1QA/C3AR1/HLA-DMA/KRT38/KRT25/FCGR2B/CFD/FCAR/KRT23/KRT36/DEFB103A/DEFB103B/KRT15/HLA-DRA/MASP2/HLA-DPA1/KRT18/DSG1/KRT14/KRT10/KRT40/C1S/DEFA5/HLA-DOA/HLA-DQB1/KRT35/MASP1/DEFB4A/FCGR3A/KRT16/C4A/C4B/C1QC/KRT9/DEFA4/CFH/HLA-DOB/HLA-DQA1/HLA-DQA2/DEFA1/DEFA1B/DEFA3/HLA-DRB3/HLA-DRB5/KRT37/HLA-DRB1/HLA-DRB4/DEFA6/KRT33A/FPR3/KRT17	85
KEGG	hsa05226	Gastric cancer	129/6408	149/8135	0.009526	0.01989	0.007646	FGF5/FZD10/CDH17/WNT2/FGF1/WNT9B/AKT2/GRB2/E2F1/GADD45B/FZD2/PIK3CB/SHC1/WNT3/LRP5/CTNNA1/WNT7B/DVL1/FGF3/SOS1/RPS6KB2/CCND1/MAP2K2/WNT7A/FGF18/WNT8B/FRAT1/DVL2/TGFB1/TGFB2/ARAF/PIK3CD/APC2/SMAD2/RXRA/MAPK1/SHC3/MTOR/AKT1/AKT3/WNT16/SMAD4/BRAF/RAF1/MAPK3/CSNK1A1/PIK3R1/CDKN1A/DDB2/FGF23/WNT10B/BAK1/CDX2/SMAD3/BAX/FZD1/HRAS/PIK3R2/MLH1/PIK3CA/WNT1/POLK/TCF7/CDKN1B/TERT/RXRB/MAP2K1/FGF10/SHH/HGF/MUC2/SOS2/WNT8A/E2F3/GADD45A/FGF6/CDKN2B/TCF7L2/TGFBR2/GADD45G/FZD9/CDK2/KRAS/FGF7/FGFR2/FGF4/FGF16/EGF/TGFBR1/CCNE2/WNT4/CCNE1/FGF17/RPS6KB1/TP53/RB1/FRAT2/DVL3/FGF22/WNT5B/CTNNA2/CTNNA3/FGF2/CTNNB1/FGF19/APC/AXIN1/LRP6/SHC2/FZD6/NRAS/BCL2/SHC4/FGF20/PIK3R3/E2F2/GAB1/WNT5A/FZD8/JUP/FZD3/RARB/FGF9/MET/RXRG/FZD7/MYC/GSK3B/ABCB1	129
KEGG	hsa00500	Starch and sucrose metabolism	34/6408	36/8135	0.01037	0.02151	0.008272	GYS2/SI/HK3/PGM1/PYGL/UGP2/G6PC/GPI/HK1/PYGM/GYG1/GAA/MGAM/HKDC1/GCK/AGL/GYS1/PYGB/AMY1A/AMY1B/AMY1C/AMY2A/GBE1/G6PC2/GBA3/G6PC3/HK2/ENPP3/TREH/PGM2L1/GANC/AMY2B/PGM2/ENPP1	34
KEGG	hsa01212	Fatty acid metabolism	52/6408	57/8135	0.01062	0.0219	0.008419	ELOVL2/ACAA1/HADHB/PPT2/HADHA/FADS2/ACSL3/ACADS/HADH/CPT1C/MECR/ACADVL/ACAA2/ELOVL1/CPT2/CBR4/ELOVL5/ECHS1/HSD17B12/ACSBG2/ACOX1/TECR/CPT1B/OXSM/MCAT/PPT1/ACSL4/HSD17B4/ELOVL3/CPT1A/ACADL/ACAT1/ACSF3/ACADSB/ACSL1/FASN/ACOX3/HSD17B8/ACACA/ACAT2/ACSL5/ACSBG1/FADS1/ELOVL4/ELOVL6/ELOVL7/ACSL6/SCD5/ACADM/SCD/SCP2/EHHADH	52
KEGG	hsa04979	Cholesterol metabolism	46/6408	50/8135	0.01102	0.0223	0.008575	CYP7A1/LIPG/PLTP/NCEH1/VDAC2/SORT1/ABCB11/SOAT1/ANGPTL4/VDAC3/NPC2/OSBPL5/LRPAP1/MYLIP/ABCA1/LRP1/LDLRAP1/CD36/LDLR/APOA1/APOE/STAR/STARD3/PCSK9/VAPA/LCAT/APOC1/SOAT2/LIPA/TSPO/APOB/VAPB/APOA4/APOC2/SCARB1/CYP27A1/NPC1/ABCG5/LPA/ABCG8/APOC3/CETP/LPL/VDAC1/ANGPTL3/LRP2	46
KEGG	hsa05110	Vibrio cholerae infection	46/6408	50/8135	0.01102	0.0223	0.008575	ATP6V1H/ACTG1/PRKACA/ATP6V0D1/SEC61B/ATP6V0A1/ATP6V0E1/ATP6AP1/ATP6V1B2/ATP6V0B/ATP6V1E2/CFTR/GNAS/ARF1/ATP6V1E1/ATP6V1D/TCIRG1/PLCG2/KCNQ1/PDIA4/SEC61A2/ACTB/KDELR1/ATP6V1B1/ATP6V1F/ATP6V1C1/SEC61G/ATP6V0E2/ATP6V0A2/KDELR2/ATP6V0C/ATP6V1A/ATP6V0D2/PRKACB/PLCG1/SEC61A1/ADCY9/ADCY3/ATP6V1G3/PRKACG/SLC12A2/TJP2/PRKCA/ATP6V1G2/ATP6V0A4/KDELR3	46
KEGG	hsa05144	Malaria	46/6408	50/8135	0.01102	0.0223	0.008575	IL12A/ITGB2/CD40/MYD88/THBS4/TGFB1/TGFB2/TLR9/ITGAL/IL10/IL1B/THBS1/LRP1/TNF/THBS3/ICAM1/CD36/SELP/CR1/HBB/HGF/PECAM1/SELE/TLR2/CD81/CSF3/SDC2/CD40LG/COMP/THBS2/CR1L/IL18/SDC1/IFNG/GYPB/CCL2/TLR4/VCAM1/GYPC/KLRK1/MET/GYPA/IL6/HBA1/HBA2/KLRB1	46
KEGG	hsa05020	Prion disease	230/6408	273/8135	0.01272	0.0256	0.009844	NCAM2/SLC25A31/RYR3/COX6A2/COX8C/COX7B2/C9/COX4I2/PSMD6/NDUFS7/UQCRB/BAD/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/PSMA6/NDUFS2/TUBA1A/PSMA3/CASP9/TUBA1C/PSMA7/ATF4/PRKACA/RAC1/MAPK14/PIK3CB/PPP3R2/PSMB1/PSMC1/CREB3/PSMC4/COX6B1/RAC2/COX8A/HSPA5/NDUFB10/PSMD1/KLC1/NDUFA4/NDUFV2/CACNA1C/SLC25A4/NCF4/CSNK2B/UQCRFS1/VDAC2/NCF1/HSPA6/NDUFB4/NDUFA10/PIK3CD/NDUFB2/UQCR10/PSMA2/PSMD12/NCF2/PSMB5/MAPK1/NDUFB11/TUBAL3/NOTCH1/GRIN2B/C6/UQCRH/PSMD2/PSMD13/COX7B/ATF6B/SDHA/COX7A2/NDUFB6/PSMD7/NDUFB8/PPIF/PPP3CB/UQCRC2/TUBA3D/TUBA3E/TUBA4A/MAPK9/ITPR3/TUBA3C/TUBB1/MAPK3/NDUFA7/FYN/CASP3/EIF2S1/PSMD4/NDUFA2/COX6C/NDUFC2/PIK3R1/ADRM1/VDAC3/NDUFA6/PRNP/PSMC6/IL1B/PSMD9/PSMC2/MAPK11/SOD1/CREB5/TUBA1B/NDUFS8/NDUFB1/BAX/MAPK13/NDUFA12/NDUFS3/PSMA1/PIK3R2/PSMC5/KIF5C/COX4I1/CYC1/PSMD11/PIK3CA/TNF/HSPA8/DDIT3/UQCR11/ITPR2/MAPK12/NDUFA9/HSPA1L/NDUFS4/SLC25A5/SDHB/HSPA1A/COX6B2/NDUFA11/KIF5B/CSNK2A2/NDUFV1/NDUFB5/NDUFAB1/EIF2AK3/SDHC/PSMB3/C1QB/CSNK2A1/COX5A/CYBA/NDUFS6/NDUFA3/NDUFB9/COX6A1/PSMD8/PSMA4/PSMB7/PRKCD/PSMD14/CYBB/PPP3CA/NDUFS5/COX7C/APAF1/GRIN2C/KLC4/C5/ATF2/C1QA/TUBA8/CYCS/CACNA1F/ITPR1/GRIN1/NDUFA8/CREB3L4/TUBB6/CREB3L2/PSMA5/PRKACB/HSPA1B/MAPK8/PSMB6/NDUFA13/RYR1/CACNA1S/CREB1/COX7A2L/NDUFA5/CASP12/PSMD3/PSMB2/PSMA8/GRIN2D/PRKACG/PSMC3/KLC3/CCL5/LAMC1/NDUFV3/SDHD/PPP3CC/CACNA1D/TUBB/CACNA1B/STIP1/C8A/TUBB3/GRIN3B/CAV2/PIK3R3/C1QC/GRIN2A/PPP3R1/MAPK10/UQCRC1/NDUFB7/GRIN3A/SLC25A6/RYR2/KLC2/VDAC1/IL6/KIF5A/CREB3L1/NDUFA4L2/HSPA2/GSK3B/IL1A/CAV3	230
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	45/6408	49/8135	0.01298	0.02594	0.009975	MPI/NANS/CYB5R3/HK3/PMM1/PGM1/GMDS/HEXB/CMAS/NAGK/UGP2/GMPPA/GALE/GMPPB/GALK1/AMDHD2/GPI/HK1/HEXA/GNPDA1/GNPNAT1/PMM2/CYB5R4/UXS1/HKDC1/GCK/GALT/NPL/CYB5R1/GFPT2/NANP/PGM3/CHIA/TSTA3/FPGT/CHIT1/CYB5RL/GFPT1/UAP1L1/GALK2/HK2/UAP1/RENBP/GNE/PGM2	45
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	26/6408	27/8135	0.01307	0.02594	0.009975	B3GALT1/B3GNT4/FUT9/FUT2/B4GALT2/B4GALT1/A4GALT/B3GNT3/B4GALT3/FUT3/ST3GAL3/FUT7/B4GALT4/FUT1/ST3GAL6/ST3GAL4/ABO/B3GNT2/FUT5/B3GNT5/GCNT2/FUT4/B3GALT2/B3GALT5/B3GALNT1/FUT6	26
KEGG	hsa05332	Graft-versus-host disease	39/6408	42/8135	0.01313	0.02594	0.009975	IL2/HLA-E/HLA-B/HLA-C/HLA-A/FAS/IL1B/TNF/KIR2DL3/KIR2DL5A/HLA-G/HLA-F/HLA-DMB/CD86/HLA-DMA/KIR3DL2/HLA-DRA/HLA-DPA1/CD80/PRF1/GZMB/HLA-DOA/HLA-DQB1/KIR2DL2/CD28/FASLG/KIR2DL1/IFNG/KIR3DL3/KLRD1/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/IL6/IL1A	39
KEGG	hsa05323	Rheumatoid arthritis	82/6408	93/8135	0.01361	0.02675	0.01028	PTH/MMP3/ATP6V1H/ITGB2/ATP6V0D1/ATP6V0A1/ATP6V0E1/ATP6AP1/ATP6V1B2/ATP6V0B/ATP6V1E2/TGFB1/TGFB2/LTB/ITGAL/ATP6V1E1/ATP6V1D/IL17A/TCIRG1/IL1B/TNFSF13/IL23A/TNF/ATP6V1B1/CXCL1/ATP6V1F/ICAM1/ATP6V1C1/JUN/HLA-DMB/ATP6V0E2/ATP6V0A2/VEGFA/CSF2/ATP6V0C/FLT1/ATP6V1A/CXCL3/ATP6V0D2/TLR2/TNFSF13B/CD86/FOS/HLA-DMA/ACP5/CTSK/ATP6V1G3/CTLA4/HLA-DRA/CCL5/HLA-DPA1/CD80/IL18/HLA-DOA/HLA-DQB1/CD28/MMP1/IL15/IFNG/ATP6V1G2/CCL20/CXCL6/CCL2/TLR4/HLA-DOB/HLA-DQA1/HLA-DQA2/CSF1/HLA-DRB3/HLA-DRB5/CCL3/CCL3L1/CCL3L3/CXCL5/HLA-DRB1/HLA-DRB4/ATP6V0A4/IL6/ANGPT1/CXCL12/TEK/IL1A	82
KEGG	hsa00983	Drug metabolism - other enzymes	71/6408	80/8135	0.01515	0.02944	0.01132	UGT2B4/UGT2A3/CYP2A7/NAT2/UGT2B17/TPMT/UPP1/MGST3/GUSB/UCK1/GSTA3/ITPA/NAT1/GMPS/GSTO1/CES2/DUT/TK1/NME1-NME2/NME2/UPB1/IMPDH1/GSTT1/NME4/XDH/NME3/HPRT1/NME6/CDA/TYMP/RRM2B/UCKL1/DPYD/RRM1/GSTO2/MGST1/GSTP1/UCK2/UMPS/MPO/UGT1A10/UGT1A7/UGT1A8/GSTT2/TK2/GSTM3/NME1/GSTM4/MGST2/GSTM1/RRM2/UPP2/CES1/CYP2A6/IMPDH2/CYP3A4/GSTM2/UGT2B15/CYP2E1/DPYS/GSTA1/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/NME7/GSTM5/UGT2A1/UGT2A2	71
KEGG	hsa04310	Wnt signaling pathway	143/6408	167/8135	0.01516	0.02944	0.01132	FZD10/WNT2/ZNRF3/LGR5/WNT9B/RSPO2/CAMK2G/PLCB2/PRKACA/RAC1/FZD2/RHOA/WNT3/LRP5/PPP3R2/RAC2/WNT7B/DVL1/PRKCB/CSNK1E/PRICKLE3/CCND1/WNT7A/WNT8B/CSNK2B/FRAT1/DVL2/CTNNBIP1/NFATC1/SOST/APC2/TBL1X/RUVBL1/CTBP2/EP300/PSEN1/WNT16/RNF43/PPP3CB/SMAD4/MAPK9/PLCB4/NOTUM/CSNK1A1/CCND3/CACYBP/PRICKLE4/WNT10B/SMAD3/SENP2/FZD1/DKK1/TLE3/WNT1/CER1/BAMBI/TBL1XR1/PLCB3/PRICKLE1/RSPO3/TCF7/CSNK2A2/SFRP5/JUN/BTRC/ROCK2/MAP3K7/RSPO4/CBY1/CSNK2A1/CUL1/CAMK2B/FRZB/CHD8/LGR6/WNT8A/PPP3CA/CTNND2/PORCN/TCF7L2/TLE4/SFRP4/FZD9/CCND2/SKP1/NFATC2/LGR4/VANGL1/FBXW11/RBX1/PRKACB/MAPK8/DKK2/NKD1/PPARD/PRICKLE2/SOX17/WNT4/PRKACG/TLE1/CXXC4/CAMK2D/DAAM1/TBL1Y/PRKCG/TLE2/TP53/PPP3CC/CAMK2A/FRAT2/DVL3/WNT5B/CTNNB1/ROR2/NFATC4/PLCB1/APC/SFRP2/CTBP1/AXIN1/LRP6/FZD6/RYK/PRKCA/CREBBP/NFATC3/WIF1/PPP3R1/MAPK10/WNT5A/FZD8/DAAM2/FZD3/SIAH1/DKK4/ROR1/GPC4/TLE6/FZD7/RSPO1/NKD2/MYC/GSK3B	143
KEGG	hsa00120	Primary bile acid biosynthesis	17/6408	17/8135	0.01723	0.03326	0.01279	CYP7A1/AKR1D1/CYP7B1/AKR1C4/CYP46A1/AMACR/SLC27A5/HSD17B4/CYP8B1/CH25H/HSD3B7/CYP27A1/ACOT8/CYP39A1/ACOX2/SCP2/BAAT	17
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	123/6408	143/8135	0.01757	0.03354	0.0129	FZD10/HOXD1/ESX1/WNT2/ZIC3/WNT9B/AKT2/IGF1/OTX1/GRB2/MEIS1/MAPK14/FZD2/PIK3CB/PCGF6/WNT3/WNT7B/DVL1/SETDB1/MAP2K2/WNT7A/WNT8B/DVL2/PIK3CD/APC2/SMAD2/MAPK1/HOXB1/AKT1/AKT3/JAK3/WNT16/SOX2/SMAD4/RAF1/MAPK3/JAK2/PIK3R1/MAPK11/LIFR/PCGF1/WNT10B/SMAD3/MAPK13/FZD1/HRAS/PIK3R2/ACVR2B/PIK3CA/SMAD1/MAPK12/ID3/WNT1/IL6ST/TCF7/HAND1/JARID2/SMAD9/MAP2K1/FGFR4/INHBB/IGF1R/PCGF3/WNT8A/BMI1/POU5F1B/ACVR1/LHX5/SKIL/DUSP9/FZD9/ACVR1B/KRAS/FGFR2/KLF4/LEFTY2/SMAD5/PCGF5/POU5F1/RIF1/WNT4/INHBE/LIF/PCGF2/STAT3/ESRRB/DVL3/WNT5B/FGF2/ONECUT1/CTNNB1/BMPR2/REST/APC/FGFR1/AXIN1/FZD6/NRAS/BMPR1B/JAK1/PIK3R3/NODAL/ZFHX3/TCF3/TBX3/WNT5A/NANOG/FZD8/NEUROG1/ACVR2A/HOXA1/INHBC/FZD3/BMPR1A/ID4/LEFTY1/MYF5/ISL1/SMARCAD1/FZD7/MYC/GSK3B/INHBA	123
KEGG	hsa05017	Spinocerebellar ataxia	123/6408	143/8135	0.01757	0.03354	0.0129	ATXN3L/GRIA2/SLC25A31/PSMD6/PIK3C3/ATXN8OS/PSMB4/AKT2/PSMA6/PSMA3/PSMA7/PLCB2/PUM1/PIK3CB/GNAQ/PIK3R4/PSMB1/PSMC1/PSMC4/PRKCB/WIPI2/ATP2A2/PSMD1/SLC25A4/VDAC2/PIK3CD/PSMA2/ATXN2L/PSMD12/PSMB5/CIC/GRIN2B/MTOR/AKT1/PSMD2/PSMD13/AKT3/PSMD7/PPIF/RB1CC1/MAPK9/ITPR3/PLCB4/ATP2A3/PSMD4/KCND3/PIK3R1/ADRM1/VDAC3/XBP1/PSMC6/PSMD9/PSMC2/KAT5/TRAF2/AMBRA1/TBPL1/PSMA1/PIK3R2/PSMC5/PSMD11/PIK3CA/MAP3K5/ITPR2/SLC25A5/DAB1/OMA1/BECN1/ATG2B/PLCB3/GTF2B/RBPJL/ATXN2/NOP56/GRIA3/PSMB3/ATXN1/ULK1/ATG2A/PSMD8/PSMA4/PSMB7/PSMD14/ULK2/ATXN1L/KCNC3/ATXN3/GRIN2C/WIPI1/AFG3L2/CYCS/ITPR1/GRIN1/PSMA5/MAPK8/PSMB6/RYR1/ATXN10/RBPJ/PSMD3/PSMB2/ERN1/PSMA8/GRIN2D/PUM2/PSMC3/PRKCG/OPA1/SLC1A6/NRBF2/PLCB1/GRIN3B/PRKCA/PIK3R3/GRIN2A/MAPK10/GRIA1/FGF14/GRIN3A/SLC25A6/TBP/VDAC1/PDYN	123
KEGG	hsa03410	Base excision repair	31/6408	33/8135	0.01818	0.03449	0.01326	PARP3/HMGB1/XRCC1/MBD4/POLB/POLD3/FEN1/POLE4/LIG3/SMUG1/NTHL1/PARP4/PARP1/POLL/POLE3/MPG/UNG/OGG1/LIG1/POLD2/APEX2/POLD1/NEIL1/POLE/PCNA/POLD4/TDG/PARP2/MUTYH/NEIL2/POLE2	31
KEGG	hsa04612	Antigen processing and presentation	69/6408	78/8135	0.01961	0.03685	0.01417	HLA-E/TAPBP/HLA-B/HLA-C/HSPA5/TAP1/HSPA4/HSPA6/NFYC/IFI30/PSME1/CD4/RFXAP/HLA-A/PSME3/CTSS/CTSB/PSME2/TNF/HSPA8/HSPA1L/KIR2DL3/KIR2DL5A/KIR2DS1/KIR2DS3/HSPA1A/HLA-G/HLA-F/HLA-DMB/TAP2/HSP90AA1/CANX/KIR2DL4/RFXANK/RFX5/HLA-DMA/HSPA1B/CD74/KIR3DL2/LGMN/CREB1/B2M/HLA-DRA/CALR/HSP90AB1/HLA-DPA1/KIR2DS5/PDIA3/HLA-DOA/CIITA/HLA-DQB1/KIR2DL2/CD8B/KIR2DL1/IFNG/KIR3DL3/KIR2DS2/KIR2DS4/KLRD1/NFYB/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/KLRC3/HLA-DRB1/HLA-DRB4/HSPA2	69
KEGG	hsa05320	Autoimmune thyroid disease	48/6408	53/8135	0.01964	0.03685	0.01417	IFNA2/IL2/IFNA1/IFNA13/HLA-E/CD40/HLA-B/HLA-C/HLA-A/FAS/IL10/CGA/HLA-G/HLA-F/HLA-DMB/IFNA8/CD86/IL4/HLA-DMA/CD40LG/CTLA4/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/HLA-DRA/IFNA16/HLA-DPA1/CD80/PRF1/GZMB/HLA-DOA/HLA-DQB1/CD28/FASLG/TSHB/HLA-DOB/IFNA17/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/TSHR	48
KEGG	hsa05224	Breast cancer	126/6408	147/8135	0.02059	0.03842	0.01477	FGF5/FZD10/WNT2/FGF1/PGR/WNT9B/AKT2/IGF1/NCOA3/GRB2/E2F1/GADD45B/FZD2/PIK3CB/SHC1/WNT3/LRP5/WNT7B/DVL1/FGF3/SOS1/RPS6KB2/CCND1/MAP2K2/WNT7A/FGF18/WNT8B/FRAT1/DVL2/NCOA1/ARAF/PIK3CD/APC2/MAPK1/NOTCH1/SHC3/MTOR/AKT1/AKT3/WNT16/PTEN/BRAF/RAF1/KIT/MAPK3/CSNK1A1/PIK3R1/CDKN1A/DDB2/FGF23/WNT10B/BAK1/BAX/FZD1/HRAS/PIK3R2/PIK3CA/WNT1/POLK/FLT4/JAG2/TCF7/JUN/NFKB2/HES1/BRCA1/JAG1/MAP2K1/FGF10/DLL3/ESR2/IGF1R/SOS2/WNT8A/E2F3/GADD45A/FGF6/TCF7L2/GADD45G/FZD9/KRAS/FGF7/FGF4/FOS/HEYL/FGF16/EGF/HES5/WNT4/DLL1/FGF17/HEY1/CDK4/RPS6KB1/TP53/RB1/FRAT2/DVL3/FGF22/WNT5B/ESR1/FGF2/CTNNB1/FGF19/APC/FGFR1/AXIN1/LRP6/SHC2/FZD6/NRAS/CDK6/NOTCH2/SHC4/FGF20/PIK3R3/E2F2/WNT5A/FZD8/BRCA2/FZD3/DLL4/FGF9/FZD7/MYC/GSK3B	126
KEGG	hsa04330	Notch signaling pathway	53/6408	59/8135	0.02083	0.03865	0.01486	HDAC1/NCSTN/DVL1/APH1B/DVL2/DTX3L/NOTCH1/CTBP2/EP300/PSEN1/DTX4/SNW1/DTX3/DTX1/NUMB/PTCRA/MFNG/HDAC2/CIR1/TLE3/ADAM17/RFNG/JAG2/RBPJL/DTX2/MAML1/HES1/JAG1/ATXN1/PSEN2/DLL3/NCOR2/NUMBL/ATXN1L/LFNG/TLE4/KAT2B/MAML2/HEYL/RBPJ/HES5/TLE1/DLL1/KAT2A/HEY1/TLE2/DVL3/CTBP1/MAML3/NOTCH2/CREBBP/DLL4/TLE6	53
KEGG	hsa04916	Melanogenesis	88/6408	101/8135	0.02145	0.03959	0.01522	FZD10/WNT2/WNT9B/CAMK2G/PLCB2/PRKACA/FZD2/GNAQ/WNT3/CREB3/WNT7B/DVL1/PRKCB/CALML6/MAP2K2/WNT7A/GNAI1/WNT8B/GNAI3/DVL2/MAPK1/EP300/GNAS/WNT16/ADCY8/PLCB4/RAF1/KIT/MAPK3/CALM2/ADCY6/WNT10B/FZD1/HRAS/WNT1/MITF/ADCY4/CALM1/GNAI2/PLCB3/TCF7/ADCY7/MAP2K1/CAMK2B/GNAO1/WNT8A/MC1R/CALML4/TCF7L2/FZD9/EDN1/CALML5/POMC/KRAS/CREB3L4/CREB3L2/PRKACB/CREB1/ADCY9/ASIP/TYRP1/ADCY3/WNT4/CALM3/PRKACG/CALML3/CAMK2D/PRKCG/CAMK2A/DVL3/WNT5B/CTNNB1/PLCB1/DCT/FZD6/PRKCA/NRAS/CREBBP/WNT5A/FZD8/EDNRB/FZD3/ADCY1/ADCY2/CREB3L1/FZD7/KITLG/GSK3B	88
KEGG	hsa04927	Cortisol synthesis and secretion	58/6408	65/8135	0.02161	0.03966	0.01525	HSD3B1/PDE8A/KCNK2/PLCB2/ATF4/PRKACA/GNAQ/CREB3/NCEH1/GNA11/CACNA1C/GNAS/MC2R/ATF6B/ADCY8/ITPR3/PLCB4/ADCY6/CREB5/HSD3B2/ITPR2/ADCY4/PLCB3/LDLR/CACNA1H/STAR/ADCY7/CYP11A1/ORAI1/AGTR1/CYP21A2/ATF2/NR4A1/CACNA1F/ITPR1/POMC/CREB3L4/CREB3L2/PRKACB/CYP17A1/CACNA1I/CACNA1S/CREB1/ADCY9/ADCY3/NR0B1/SCARB1/PRKACG/KCNK3/CACNA1D/PBX1/PLCB1/CYP11B1/CACNA1G/ADCY1/PDE8B/ADCY2/CREB3L1	58
KEGG	hsa00640	Propanoate metabolism	30/6408	32/8135	0.02185	0.03988	0.01533	LDHAL6B/HADHA/SUCLG1/BCKDHA/LDHAL6A/ACADS/MLYCD/DLD/ACSS2/ECHS1/ACOX1/PCCA/ECHDC1/LDHA/HIBCH/DBT/PCCB/SUCLA2/ABAT/MCEE/ACSS1/LDHB/ACOX3/ACACA/BCKDHB/ACSS3/LDHC/ACACB/EHHADH/ALDH6A1	30
KEGG	hsa05213	Endometrial cancer	52/6408	58/8135	0.02401	0.04359	0.01676	BAD/AKT2/GRB2/CASP9/GADD45B/PIK3CB/CTNNA1/ILK/SOS1/CCND1/MAP2K2/ARAF/PIK3CD/APC2/MAPK1/AKT1/AKT3/ELK1/PTEN/BRAF/RAF1/MAPK3/PIK3R1/CDKN1A/DDB2/BAK1/BAX/HRAS/PIK3R2/MLH1/PIK3CA/POLK/TCF7/MAP2K1/SOS2/GADD45A/TCF7L2/GADD45G/KRAS/EGF/TP53/CTNNA2/CTNNA3/CTNNB1/APC/AXIN1/NRAS/FOXO3/PIK3R3/PDPK1/MYC/GSK3B	52
KEGG	hsa05014	Amyotrophic lateral sclerosis	302/6408	364/8135	0.02426	0.04379	0.01684	GRIA2/UBQLN3/COX6A2/COX8C/COX7B2/GPX5/COX4I2/PSMD6/PIK3C3/NDUFS7/UQCRB/BAD/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/ACTG1/PSMA6/NDUFS2/ACTR10/TUBA1A/PSMA3/CASP9/TUBA1C/PSMA7/ATF4/RAC1/MAPK14/PIK3R4/PPP3R2/RAE1/PSMB1/PSMC1/PSMC4/TNFRSF1B/COX6B1/WIPI2/COX8A/HSPA5/ANXA11/RAB1A/NDUFB10/ACTR1A/PSMD1/KLC1/NDUFA4/UBQLN1/DNAL4/MAP1LC3B/NDUFV2/TOMM40L/NUP214/UQCRFS1/TOMM40/TBK1/NXF1/NDUFB4/NDUFA10/NDUFB2/UQCR10/PSMA2/PINK1/ATXN2L/PSMD12/NUP98/PSMB5/TNFRSF1A/NDUFB11/TUBAL3/GRIN2B/MTOR/RAB5A/UQCRH/PSMD2/DAXX/PSMD13/UBQLN2/TARDBP/SEC13/COX7B/SDHA/COX7A2/NUP188/NDUFB6/DNAH1/PSMD7/NDUFB8/SMCR8/MATR3/PPP3CB/SQSTM1/UQCRC2/RB1CC1/TUBA3D/TUBA3E/TUBA4A/ITPR3/TUBA3C/TUBB1/NDUFA7/CASP3/SPG11/DNAH7/FIG4/EIF2S1/PSMD4/NCBP1/NUP85/NDUFA2/COX6C/DCTN6/NDUFC2/VCP/ADRM1/MAP1LC3A/XBP1/NXT2/NDUFA6/PSMC6/NUP50/RANBP2/POM121/POM121C/PSMD9/PSMC2/DCTN1/MAPK11/SOD1/TUBA1B/NUP62/ALS2/TRAF2/SETX/AMBRA1/C9orf72/DCTN2/ACTR1B/NDUFS8/NDUFB1/BAX/ACTB/MAPK13/NDUFA12/NDUFS3/BID/PSMA1/NEFL/BCL2L1/PSMC5/KIF5C/COX4I1/CYC1/HNRNPA3/PSMD11/CAT/MAP3K5/TNF/DDIT3/UQCR11/MAPK12/HNRNPA2B1/NDUFA9/NDUFS4/PFN4/ATF6/CASP1/NUP37/NUP133/DNAH2/HAP1/GLE1/SDHB/BECN1/COX6B2/CHMP2B/ATG2B/NDUFA11/KIF5B/DNAH9/NUP93/ATXN2/DCTN3/NDUFV1/NDUFB5/NDUFAB1/NUP205/EIF2AK3/SDHC/TPR/PSMB3/MAP2K6/PFN1/DNAH17/ULK1/ATG2A/COX5A/HDAC6/NDUFS6/NUP155/MAP1LC3C/NDUFA3/NUP153/NDUFB9/DCTN5/DERL1/COX6A1/HNRNPA1/HNRNPA1L2/PSMD8/SIGMAR1/NXF2/NXF2B/PSMA4/PSMB7/NXT1/PSMD14/NUP88/ULK2/PPP3CA/NDUFS5/RAB39B/COX7C/APAF1/GRIN2C/WIPI1/KLC4/NEFH/DNAI1/WDR41/TUBA8/CYCS/CCS/DNAI2/GRIN1/NDUFA8/TUBB6/PSMA5/DCTN4/NEFM/VAPB/NUP35/PSMB6/CHCHD10/NDUFA13/NUP43/ANG/NUP107/UBQLN4/COX7A2L/NDUFA5/DNAH3/CASP12/PSMD3/PSMB2/ERN1/NUP210/PSMA8/GPX7/GRIN2D/PSMC3/GPX2/KLC3/NUP160/NDUFV3/DNAH10/TP53/SDHD/PPP3CC/NRG1/TUBB/MAP1LC3B2/DNAH8/OPTN/NRBF2/ERBB4/POM121L2/TUBB3/MAP2K3/BCL2/TANK/GRIN2A/PPP3R1/PFN2/NUP54/UQCRC1/RAB8A/GPX1/GRIA1/NDUFB7/DNAL1/KLC2/ANXA7/VDAC1/FUS/KIF5A/DNAH6/DNALI1/NDUFA4L2/GPX8	302
KEGG	hsa03022	Basal transcription factors	41/6408	45/8135	0.02464	0.04424	0.01701	GTF2H1/ERCC3/GTF2E2/TAF7/GTF2I/CCNH/GTF2F2/GTF2F1/GTF2A2/GTF2H2/GTF2H2C/CDK7/TAF1/TAF10/TAF9/TBPL1/TAF2/TAF11/TAF5/GTF2B/TAF12/TAF9B/TAF5L/GTF2H5/TAF1L/TAF13/TAF6/GTF2E1/GTF2A1L/ERCC2/TAF3/TAF4/TAF8/GTF2A1/TAF15/MNAT1/GTF2H3/GTF2H4/TAF7L/TBP/GTF2IRD1	41
KEGG	hsa05330	Allograft rejection	35/6408	38/8135	0.02597	0.04615	0.01774	IL12A/IL2/HLA-E/CD40/HLA-B/HLA-C/HLA-A/FAS/IL10/TNF/HLA-G/HLA-F/HLA-DMB/CD86/IL4/HLA-DMA/IL12B/CD40LG/HLA-DRA/HLA-DPA1/CD80/PRF1/GZMB/HLA-DOA/HLA-DQB1/CD28/FASLG/IFNG/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4	35
KEGG	hsa05340	Primary immunodeficiency	35/6408	38/8135	0.02597	0.04615	0.01774	DCLRE1C/CD40/BTK/IL2RG/TAP1/IKBKG/JAK3/CD4/RFXAP/UNG/PTPRC/CD3D/ORAI1/RAG1/TNFRSF13B/TAP2/IGLL1/LCK/RFXANK/ICOS/ZAP70/RFX5/AIRE/CD40LG/CD19/ADA/IL7R/CIITA/CD8B/CD3E/BLNK/CD79A/RAG2/AICDA/TNFRSF13C	35
KEGG	hsa04640	Hematopoietic cell lineage	86/6408	99/8135	0.02681	0.04738	0.01822	CD1B/ITGA5/ITGA2/EPOR/ITGAM/GP9/CD55/CD4/IL6R/CSF3R/KIT/ITGA2B/IL2RA/CD59/IL1B/CD14/CSF1R/CD33/IL4R/TNF/CD37/IL11RA/CD36/MME/CR1/GP5/HLA-DMB/CD3D/TFRC/CD34/CD7/CSF2/ANPEP/IL1R2/CD38/GP1BB/FCGR1A/GP1BA/IL3/CD1D/CD2/CSF3/IL9R/IL4/CSF2RA/ITGA4/HLA-DMA/ITGB3/CD44/DNTT/IL3RA/CD3G/HLA-DRA/FLT3LG/CD5/CD19/HLA-DPA1/CR1L/FCER2/IL7R/EPO/HLA-DOA/CD24/HLA-DQB1/FLT3/CD8B/IL5RA/IL1R1/THPO/CD22/CD3E/HLA-DOB/CD1C/HLA-DQA1/HLA-DQA2/CSF1/HLA-DRB3/HLA-DRB5/ITGA3/HLA-DRB1/HLA-DRB4/IL7/GYPA/IL6/KITLG/IL1A	86
KEGG	hsa04970	Salivary secretion	81/6408	93/8135	0.02744	0.04823	0.01854	BEST2/STATH/HTN1/MUC7/RYR3/HTN3/TRPV6/ADRA1D/PRH1/PRH2/PLCB2/PRKACA/PRKG2/GNAQ/PRKCB/CALML6/GNAS/ATP1B3/ADRA1A/ADCY8/SLC9A1/ITPR3/PLCB4/SLC4A2/CALM2/ADCY6/ATP2B2/ATP2B1/GUCY1A2/ITPR2/MUC5B/CHRM3/ADCY4/CALM1/PLCB3/BST1/LPO/ADCY7/CST5/PRB1/CST4/CST3/AMY1A/AMY1B/AMY1C/AMY2A/CD38/CAMP/CALML4/CST2/ATP2B3/DMBT1/CALML5/ITPR1/ATP2B4/VAMP2/PRKACB/FXYD2/ADCY9/ATP1A1/ADCY3/CALM3/PRKACG/CALML3/ADRB2/PRKCG/KCNN4/SLC12A2/LYZ/PLCB1/PRKCA/ADRB1/ADCY1/AMY2B/PRKG1/LYZL1/ATP1A4/ADCY2/ATP1A3/PRB2/ATP1A2	81
KEGG	hsa04924	Renin secretion	61/6408	69/8135	0.0286	0.05001	0.01923	CLCA1/CLCA4/PLCB2/PRKACA/PRKG2/GNAQ/PDE1A/NPPA/PPP3R2/CALML6/PTGER4/CACNA1C/GNAI1/GNAI3/GNAS/NPR1/PPP3CB/ITPR3/PLCB4/CALM2/PDE1B/ADCY6/REN/PTGER2/CTSB/GUCY1A2/ITPR2/CALM1/GNAI2/PLCB3/KCNJ2/ORAI1/AGTR1/PPP3CA/CALML4/PDE3A/ADCYAP1R1/EDN1/CALML5/CACNA1F/ITPR1/ADORA1/PRKACB/CACNA1S/CREB1/CALM3/PRKACG/CALML3/ADRB2/PPP3CC/CACNA1D/ACE/PLCB1/EDNRA/PDE3B/ADRB1/PPP3R1/CLCA2/EDN2/ADCYAP1/PDE1C	61
KEGG	hsa03060	Protein export	22/6408	23/8135	0.0296	0.05122	0.0197	SEC61B/HSPA5/SEC11A/SRP19/SRP14/SEC11C/SRP72/SEC61A2/OXA1L/SPCS2/SRP9/IMMP2L/SRP68/SEC61G/SEC61A1/SRPRB/SEC62/SPCS3/SPCS1/SRP54/IMMP1L/SEC63	22
KEGG	hsa03430	Mismatch repair	22/6408	23/8135	0.0296	0.05122	0.0197	MSH3/PMS2/POLD3/MSH6/MLH1/SSBP1/RFC2/RFC3/LIG1/POLD2/RFC5/RPA3/RFC1/POLD1/MLH3/RPA1/PCNA/POLD4/RPA2/MSH2/EXO1/RFC4	22
KEGG	hsa04726	Serotonergic synapse	99/6408	115/8135	0.0302	0.052	0.01999	CYP4X1/GNG13/HTR1D/TPH2/HTR2C/CYP2C19/KCND2/GNG5/GABRB1/KCNN2/PLCB2/PRKACA/GNB1/GNAQ/PTGS1/GNG2/PRKCB/PLA2G4D/GNG10/KCNJ6/CACNA1C/GNAI1/APP/GNAI3/ARAF/MAPK1/PLA2G4C/GNAS/GNGT2/ITPR3/PLCB4/BRAF/CYP2D6/RAF1/MAPK3/GNB2/CASP3/HTR6/GNB5/HRAS/JMJD7-PLA2G4B/PLA2G4B/ITPR2/HTR2A/CYP2J2/GNAI2/PLCB3/ALOX5/HTR2B/GNB3/GNG3/KCNJ5/MAP2K1/ALOX12/CYP2C18/PLA2G4F/GNAO1/GNG7/GNG11/DUSP1/HTR7/ALOX12B/MAOA/CACNA1F/ITPR1/KRAS/PTGS2/GNG8/PRKACB/HTR5A/CACNA1S/GNB4/GNGT1/CYP2C9/GNG12/HTR1F/PRKACG/HTR3C/PRKCG/CYP2C8/CACNA1D/ALOX15/KCNJ3/HTR3B/CACNA1B/SLC18A2/HTR1A/PLCB1/HTR1B/PRKCA/NRAS/HTR1E/RAPGEF3/PLA2G4A/SLC18A1/MAOB/GABRB3/GNG4/DDC	99
KEGG	hsa00510	N-Glycan biosynthesis	45/6408	50/8135	0.03065	0.05228	0.0201	MGAT4C/ALG12/MGAT4B/ALG3/B4GALT2/B4GALT1/ALG10B/ALG2/TUSC3/B4GALT3/DPAGT1/MGAT3/DAD1/DOLK/MGAT1/STT3B/ALG6/MAN1B1/RPN2/MOGS/MGAT5/MGAT5B/ALG5/DDOST/ALG14/MAN2A2/DPM1/GANAB/SRD5A3/ALG9/ALG13/ST6GAL2/MAN1C1/DOLPP1/MAN1A1/DPM3/MGAT2/DPM2/STT3A/ALG8/ST6GAL1/MAN1A2/ALG1/ALG10/FUT8	45
KEGG	hsa05216	Thyroid cancer	34/6408	37/8135	0.03068	0.05228	0.0201	GADD45B/CCND1/MAP2K2/RXRA/MAPK1/TPM3/BRAF/MAPK3/RET/CDKN1A/DDB2/BAK1/BAX/HRAS/POLK/TCF7/CCDC6/RXRB/TPR/MAP2K1/NCOA4/NTRK1/GADD45A/TCF7L2/PAX8/GADD45G/TFG/KRAS/TP53/CTNNB1/NRAS/RXRG/PPARG/MYC	34
KEGG	hsa04110	Cell cycle	108/6408	126/8135	0.03092	0.05242	0.02016	CCNB3/E2F1/MDM2/ZBTB17/ANAPC1/GADD45B/HDAC1/ANAPC7/CCND1/TTK/TGFB1/TGFB2/ANAPC2/CCNH/ANAPC10/SMAD2/SFN/EP300/MCM7/CDK7/YWHAB/SMC1A/SMAD4/CDC27/PTTG2/SMC3/CDC26/CCND3/CDKN1A/TFDP2/ANAPC5/CDK1/SMAD3/HDAC2/CDKN2D/YWHAQ/CDC14A/SMC1B/ANAPC4/YWHAZ/ATR/CDC25B/ANAPC13/YWHAG/PTTG1/CDKN1B/MCM5/RAD21/CDKN2C/RBL2/CUL1/MCM3/CDC14B/PRKDC/ANAPC11/PKMYT1/YWHAE/CDKN2A/ATM/MCM2/FZR1/CCNA2/ABL1/MAD2L2/E2F3/GADD45A/E2F4/CDC16/CHEK2/CDKN2B/GADD45G/MAD1L1/CCND2/SKP1/CDK2/RBX1/PCNA/STAG2/CDC7/CCNE2/DBF4/CCNE1/CDK4/TP53/RB1/BUB1B/BUB1/MCM6/ANAPC16/SKP2/STAG1/CDK6/E2F2/RBL1/CDC23/CREBBP/CDC25C/CDKN1C/BUB3/CCNB2/CDC45/MCM4/E2F5/YWHAH/CDC6/MYC/GSK3B/WEE1	108
KEGG	hsa00030	Pentose phosphate pathway	28/6408	30/8135	0.03142	0.05274	0.02028	ALDOB/TKTL2/PRPS1L1/FBP1/GLYCTK/TALDO1/DERA/PGM1/PFKP/RBKS/ALDOA/TKT/GPI/G6PD/PRPS2/PGD/ALDOC/PGLS/PFKM/PFKL/RPE/H6PD/RGN/PRPS1/RPIA/TKTL1/PGM2/FBP2	28
KEGG	hsa01523	Antifolate resistance	28/6408	30/8135	0.03142	0.05274	0.02028	FOLR2/IKBKG/ABCC1/MTHFR/SLC19A1/IL1B/IKBKB/TNF/ATIC/RELA/DHFR/ALOX12/ABCC5/NFKB1/ABCC4/SHMT2/ABCC3/ABCC2/GGH/FOLR3/FOLR1/ABCG2/CHUK/TYMS/SHMT1/SLC46A1/IL6/GART	28
KEGG	hsa00071	Fatty acid degradation	39/6408	43/8135	0.03361	0.05613	0.02158	ADH1B/ADH7/ACAA1/HADHB/HADHA/ACSL3/ACADS/HADH/CPT1C/ALDH9A1/ADH5/ACADVL/ACAA2/CPT2/ECHS1/ACSBG2/ACOX1/ADH1A/CPT1B/ACSL4/ALDH2/CPT1A/ALDH1B1/ACADL/ACAT1/ACADSB/ALDH7A1/GCDH/ACSL1/ACOX3/ALDH3A2/ACAT2/ACSL5/ACSBG1/ACSL6/ACADM/CYP2U1/ADH1C/EHHADH	39
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	178/6408	212/8135	0.03384	0.05623	0.02162	FGF5/UGT2B4/UGT2A3/CHRNA9/PAQR5/PGR/UGT2B17/BAD/AKT2/BCL6/PPARA/GRB2/E2F1/ATF4/PRKACA/CHRNA4/PIK3CB/CHRNB4/STAT5B/CREB3/PRKCB/AIP/FGF3/ARRB1/SOS1/RPS6KB2/CCND1/MAP2K2/STAT5A/AIPL1/HSP90B1/FGF18/CACNA1C/GNAI1/MGST3/GNAI3/CHRNB2/PIK3CD/RPS6KA1/RXRA/GSTA3/MAPK1/MTOR/ARRB2/KPNB1/AKT1/GNAS/AKT3/ATF6B/RPS6KA3/ADCY8/RAF1/MAPK3/JAK2/VDR/CCND3/PIK3R1/ADCY6/PTGES3/CREB5/GSTO1/EIF4EBP1/CHRNA3/KLF5/HRAS/PIK3R2/PIK3CA/WNT1/ADCY4/KPNA2/KPNA6/XIAP/GNAI2/JUN/EPHX1/RXRB/ADCY7/GSTT1/RELA/JAG1/MAP2K1/FGF10/MIRLET7D/DLL3/ESR2/VEGFA/RPS6KA2/HSP90AA1/NFKB1/PAQR7/SOS2/IKBKE/CYP1A1/FGF6/KPNA1/ATF2/CACNA1F/KRAS/FGF7/KLF4/CREB3L4/FGF4/CREB3L2/FOS/PRKACB/FGF16/EGF/CACNA1S/GSTO2/CHRNA7/CREB1/ADCY9/CYP2B6/ADCY3/CYP1B1/MGST1/PRKACG/DLL1/SRC/HSP90AB1/ADRB2/FGF17/KPNA5/PRKCG/UGT1A10/UGT1A7/UGT1A8/STAT3/GSTT2/RPS6KB1/RB1/CACNA1D/GSTM3/CACNA1B/FGF22/GSTM4/ESR1/KPNA4/MGST2/FGF2/GSTM1/PAQR8/AHR/ARNT/PRKCA/NRAS/BCL2/CYP3A4/AR/GSTM2/NOTCH2/FGF20/PIK3R3/UGT2B15/RPS6KA6/KPNA3/ADRB1/EPHX3/GSTA1/ADCY1/DLL4/FGF9/CYP1A2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/RXRG/EPHX2/GSTM5/ADCY2/CREB3L1/CDC6/MYC/UGT2A1/UGT2A2	178
KEGG	hsa05016	Huntington disease	254/6408	306/8135	0.03543	0.05859	0.02253	GRIA2/SLC25A31/COX6A2/COX8C/COX7B2/GPX5/COX4I2/PSMD6/PIK3C3/NDUFS7/POLR2B/UQCRB/UQCRQ/PSMB4/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/PSMA6/NDUFS2/ACTR10/TUBA1A/PSMA3/CASP9/TUBA1C/PSMA7/PLCB2/GNAQ/HTT/HDAC1/PIK3R4/POLR2G/PSMB1/PSMC1/CREB3/PSMC4/COX6B1/WIPI2/COX8A/CLTC/NDUFB10/ACTR1A/PSMD1/KLC1/NDUFA4/DNAL4/NDUFV2/SLC25A4/UQCRFS1/VDAC2/NDUFB4/NDUFA10/NDUFB2/UQCR10/PSMA2/POLR2A/PSMD12/PSMB5/POLR2C/NDUFB11/TUBAL3/GRIN2B/MTOR/EP300/UQCRH/PSMD2/PSMD13/COX7B/SDHA/COX7A2/NDUFB6/DNAH1/PSMD7/NDUFB8/PPIF/UQCRC2/RB1CC1/TUBA3D/TUBA3E/TUBA4A/MAPK9/POLR2E/PLCB4/TUBA3C/TUBB1/NDUFA7/AP2A2/CASP3/DNAH7/PSMD4/NDUFA2/COX6C/DCTN6/NDUFC2/ADRM1/CASP8/VDAC3/POLR2F/NDUFA6/PSMC6/PSMD9/PSMC2/DCTN1/SOD1/CREB5/TUBA1B/CLTCL1/TRAF2/AMBRA1/DCTN2/ACTR1B/TBPL1/NDUFS8/NDUFB1/BAX/NDUFA12/NDUFS3/HDAC2/BBC3/AP2M1/PSMA1/PSMC5/KIF5C/COX4I1/CYC1/DLG4/PSMD11/MAP3K5/POLR2I/POLR2H/UQCR11/NDUFA9/NDUFS4/SLC25A5/DNAH2/HAP1/SDHB/BECN1/COX6B2/ATG2B/PLCB3/NDUFA11/KIF5B/DNAH9/DCTN3/NDUFV1/MAP3K10/CLTA/NDUFB5/NDUFAB1/GRIA3/TFAM/CLTB/SDHC/STX1A/PSMB3/DNAH17/ULK1/ATG2A/COX5A/NDUFS6/NDUFA3/NDUFB9/DCTN5/NRF1/COX6A1/PSMD8/PSMA4/PSMB7/RCOR1/PSMD14/ULK2/NDUFS5/COX7C/APAF1/MAP2K7/WIPI1/POLR2J/KLC4/SIN3A/DNAI1/TUBA8/CYCS/ITPR1/TAF4/DNAI2/GRIN1/NDUFA8/CREB3L4/SOD2/TUBB6/CREB3L2/PSMA5/DCTN4/MAPK8/PSMB6/NDUFA13/CREB1/UCP1/COX7A2L/NDUFA5/HIP1/POLR2K/AP2S1/DNAH3/PSMD3/PSMB2/ERN1/PSMA8/GPX7/PSMC3/AP2A1/GPX2/KLC3/AP2B1/NDUFV3/DNAH10/TP53/SDHD/SLC1A3/TUBB/GRIA4/POLR2D/CACNA1B/DNAH8/POLR2L/TGM2/BDNF/NRBF2/REST/PLCB1/TUBB3/CREBBP/MAPK10/UQCRC1/GPX1/GRIA1/NDUFB7/KCNJ10/SLC25A6/TBP/DNAL1/IFT57/KLC2/VDAC1/KIF5A/PPARG/CREB3L1/DNAH6/DNALI1/POLR2J2/NDUFA4L2/GPX8	254
KEGG	hsa03018	RNA degradation	69/6408	79/8135	0.03592	0.0591	0.02272	PABPC4L/PABPC5/PABPC1L2B/CNOT1/EDC4/ENO1/CNOT10/LSM4/EXOSC1/EXOSC4/LSM2/CNOT2/CNOT4/ENO3/BTG1/EXOSC5/PFKP/EXOSC3/LSM3/EDC3/LSM6/DIS3/NUDT16/PARN/CNOT8/PABPC1/DCP1A/EXOSC8/XRN1/PABPC1L/DCP2/SKIV2L/LSM1/DCP1B/BTG2/HSPD1/EXOSC9/ENO2/PATL1/LSM5/WDR61/EXOSC2/PABPC3/PFKM/PFKL/BTG4/PAN3/DDX6/C1D/ZCCHC7/CNOT3/EXOSC7/DCPS/EXOSC10/PAN2/CNOT6/LSM7/MPHOSPH6/DIS3L/HSPA9/TOB2/EXOSC6/TOB1/DHX36/CNOT6L/TTC37/XRN2/PABPC4/BTG3	69
KEGG	hsa03030	DNA replication	33/6408	36/8135	0.03617	0.05922	0.02277	POLA2/POLD3/RNASEH2C/RNASEH2A/MCM7/FEN1/POLE4/SSBP1/RFC2/POLE3/RFC3/LIG1/MCM5/RNASEH2B/RNASEH1/MCM3/POLD2/RFC5/RPA3/MCM2/RFC1/POLD1/POLE/PRIM1/RPA1/PCNA/POLD4/RPA2/MCM6/PRIM2/POLE2/MCM4/RFC4	33
KEGG	hsa04150	mTOR signaling pathway	132/6408	156/8135	0.04054	0.06605	0.0254	FZD10/WNT2/ATP6V1H/WNT9B/RNF152/AKT2/IGF1/GRB2/FZD2/PIK3CB/RHOA/RRAGA/WNT3/LRP5/RRAGD/RPTOR/STRADA/WNT7B/DVL1/PRKCB/TSC1/SOS1/RPS6KB2/MAP2K2/WNT7A/ATP6V1B2/WNT8B/ATP6V1E2/DVL2/TELO2/PIK3CD/RPS6KA1/TNFRSF1A/MAPK1/MLST8/MTOR/TSC2/AKT1/AKT1S1/AKT3/SEC13/WNT16/RPS6KA3/RPS6/PTEN/ATP6V1E1/BRAF/ATP6V1D/RAF1/MAPK3/RHEB/TBC1D7/NPRL2/PIK3R1/STK11/EIF4E2/CAB39L/RRAGC/WNT10B/EIF4EBP1/FZD1/HRAS/PIK3R2/MAPKAP1/IKBKB/PIK3CA/TNF/CLIP1/WNT1/ATP6V1B1/WDR59/ATP6V1F/WDR24/CAB39/ATP6V1C1/PRKAA1/SLC7A5/IRS1/GRB10/SESN2/MAP2K1/ULK1/MIOS/PRR5/RPS6KA2/RRAGB/SLC3A2/LPIN3/IGF1R/SOS2/ULK2/WNT8A/ATP6V1A/FZD9/PRR5L/RICTOR/KRAS/LPIN1/LPIN2/EIF4B/DEPDC5/EIF4E/ATP6V1G3/WNT4/INSR/PRKCG/INS/RPS6KB1/SKP2/DVL3/FNIP2/WNT5B/LRP6/FZD6/PRKCA/NRAS/NPRL3/CHUK/PIK3R3/FNIP1/RPS6KA6/PDPK1/ATP6V1G2/WNT5A/DDIT4/FZD8/FZD3/PRKAA2/FZD7/SGK1/FLCN/GSK3B	132
KEGG	hsa04730	Long-term depression	53/6408	60/8135	0.04195	0.06801	0.02615	GRIA2/IGF1/PPP2CA/PLCB2/GNA13/CRHR1/PRKG2/GNAQ/PRKCB/PLA2G4D/MAP2K2/CRH/GNA11/GNAI1/GNAI3/ARAF/MAPK1/PLA2G4C/GNAS/ITPR3/PLCB4/BRAF/RAF1/MAPK3/HRAS/JMJD7-PLA2G4B/PLA2G4B/GUCY1A2/ITPR2/GNAI2/PLCB3/LYN/GRIA3/MAP2K1/PLA2G4F/GNAO1/GNAZ/IGF1R/PPP2R1A/GRID2/ITPR1/KRAS/RYR1/GNA12/PRKCG/PPP2CB/PLCB1/PRKCA/NRAS/PLA2G4A/PPP2R1B/GRIA1/PRKG1	53
KEGG	hsa04976	Bile secretion	77/6408	89/8135	0.04266	0.06884	0.02647	CYP7A1/UGT2B4/UGT2A3/SLCO1B3/SLC10A2/UGT2B17/KCNN2/PRKACA/NCEH1/HMGCR/ABCB11/CFTR/RXRA/GNAS/ATP1B3/ADCY8/SLC9A1/SLC4A2/ADCY6/AQP9/SLC22A8/ADCY4/SLC4A5/SULT2A1/SLC27A5/LDLR/EPHX1/ADCY7/SLC22A7/ABCC4/SLC22A1/PRKACB/AQP8/SLC2A1/ABCC3/ABCC2/FXYD2/ADCY9/SLC9A3/SLCO1B1/ATP1A1/ADCY3/SCARB1/PRKACG/SLCO1A2/NR0B2/SLC10A1/UGT1A10/UGT1A7/UGT1A8/NR1H4/ABCG5/CA2/SCT/ABCG2/CYP3A4/ABCG8/UGT2B15/ADCY1/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/SCTR/BAAT/ATP1A4/SLC5A1/ADCY2/SLC4A4/ATP1A3/ATP1A2/UGT2A1/UGT2A2/ABCB1/ABCB4	77
KEGG	hsa00770	Pantothenate and CoA biosynthesis	20/6408	21/8135	0.04418	0.07095	0.02728	PPCS/COASY/PANK2/PPCDC/ALDH2/UPB1/ALDH1B1/CSAD/BCAT1/DPYD/ALDH3A2/VNN2/BCAT2/AASDHPPT/VNN1/ENPP3/GADL1/DPYS/ENPP1/PANK1	20
KEGG	hsa00620	Pyruvate metabolism	42/6408	47/8135	0.04709	0.07489	0.0288	ACOT12/LDHAL6B/PCK1/ADH1B/ADH7/LDHAL6A/PDHA2/ALDH9A1/ADH5/DLD/AKR1A1/MDH1/ME2/MDH2/ACSS2/ADH1A/PDHB/FH/PCK2/LDHA/ALDH2/PDHA1/GRHPR/ALDH1B1/ACAT1/GLO1/PC/ALDH7A1/ACSS1/LDHB/ACYP1/PKLR/ACACA/ALDH3A2/ACAT2/ACYP2/ME3/HAGH/LDHC/ACACB/DLAT/ADH1C	42
KEGG	hsa04973	Carbohydrate digestion and absorption	42/6408	47/8135	0.04709	0.07489	0.0288	SI/SLC2A2/TAS1R2/GNAT3/AKT2/PLCB2/PIK3CB/PRKCB/PIK3CD/HK3/AKT1/ATP1B3/SLC37A4/AKT3/PLCB4/PIK3R1/G6PC/PIK3R2/PIK3CA/HK1/PLCB3/MGAM/HKDC1/SLC2A5/AMY1A/AMY1B/AMY1C/AMY2A/G6PC2/G6PC3/FXYD2/ATP1A1/HK2/CACNA1D/PLCB1/PIK3R3/LCT/AMY2B/ATP1A4/SLC5A1/ATP1A3/ATP1A2	42
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	186/6408	223/8135	0.04818	0.07627	0.02932	SLC25A31/COX6A2/COX8C/COX7B2/NOX1/COX4I2/NDUFS7/UQCRB/BAD/UQCRQ/AKR1C4/COX5B/NDUFS1/NDUFC1/AKT2/NDUFB3/PTPN1/NDUFA1/NDUFS2/GRB2/RAC1/MAPK14/PIK3CB/CYP2F1/COX6B1/COX8A/SOS1/NDUFB10/MAP2K2/NDUFA4/IKBKG/NDUFV2/SLC25A4/MGST3/UQCRFS1/VDAC2/NCF1/NDUFB4/ARAF/NDUFA10/PIK3CD/NDUFB2/UQCR10/NCF2/GSTA3/MAPK1/NDUFB11/AKT1/UQCRH/PLD2/AKT3/COX7B/KEAP1/SDHA/COX7A2/NDUFB6/NDUFB8/PPIF/PRKD2/SLC26A6/PTEN/UQCRC2/AKR1A1/MAPK9/BRAF/RAF1/MAPK3/NDUFA7/NDUFA2/COX6C/NDUFC2/PIK3R1/VDAC3/NDUFA6/MAPK11/SOD1/GSTO1/NQO1/PLD1/NDUFS8/NFKBIA/NDUFB1/AKR1C2/MAPK13/NDUFA12/NDUFS3/HRAS/PIK3R2/IKBKB/PTPRJ/COX4I1/CYC1/CAT/PIK3CA/MAP3K5/UQCR11/MAPK12/NDUFA9/ABL2/NDUFS4/SLC25A5/SDHB/COX6B2/NDUFA11/NDUFV1/JUN/MAP2K4/NDUFB5/NDUFAB1/LPO/EPHX1/SDHC/GSTT1/PTK2/RELA/MAP2K1/COX5A/CYBA/NDUFS6/HGF/NDUFA3/VEGFA/NDUFB9/ACP1/COX6A1/NFKB1/NFE2L2/PRKCD/SOS2/ABL1/NDUFS5/COX7C/CYP1A1/HIF1A/PRKD1/MAP2K7/KRAS/NDUFA8/SOD2/FOS/MAPK8/SLC26A1/NDUFA13/EGF/GSTO2/CBR1/COX7A2L/NDUFA5/CYP1B1/MGST1/NOX4/SRC/MAP3K14/PTPN11/NDUFV3/GSTT2/SDHD/GSTM3/GSTM4/SLC26A2/MGST2/GSTM1/AHR/ARNT/NRAS/FOXO3/CHUK/GSTM2/PIK3R3/CYP2E1/PDPK1/AKR1C3/EPHX3/MAPK10/UQCRC1/NDUFB7/GSTA1/HMOX1/SLC25A6/SLC26A9/CYP1A2/MET/EPHX2/VDAC1/GSTM5/NDUFA4L2	186
KEGG	hsa03020	RNA polymerase	31/6408	34/8135	0.04999	0.07876	0.03028	POLR2B/POLR2G/POLR2A/POLR2C/POLR3H/POLR3C/ZNRD1/POLR2E/POLR2F/POLR2I/POLR2H/POLR3D/POLR1E/POLR1C/POLR3G/POLR3F/POLR3E/POLR2J/POLR3GL/POLR3K/POLR2K/POLR1B/POLR2D/CD3EAP/POLR1D/POLR2L/TWISTNB/POLR3B/POLR3A/CRCP/POLR2J2	31
KEGG	hsa04966	Collecting duct acid secretion	25/6408	27/8135	0.05347	0.08385	0.03224	ATP6V0D1/ATP6V0A1/ATP6V0E1/ATP4B/ATP6V1B2/ATP6V1E2/ATP6V1E1/ATP6V1D/TCIRG1/SLC12A7/ATP6V1B1/ATP6V1F/ATP6V1C1/ATP6V0E2/ATP6V0A2/ATP6V0C/ATP6V1A/ATP6V0D2/ATP6V1G3/SLC4A1/CA2/CLCNKB/ATP6V1G2/ATP6V0A4/ATP4A	25
KEGG	hsa04114	Oocyte meiosis	111/6408	131/8135	0.05373	0.08386	0.03224	SPDYA/PGR/PPP2R5D/PPP2R5C/IGF1/PPP2CA/CAMK2G/PRKACA/ANAPC1/MAPK14/PPP3R2/ANAPC7/CALML6/PPP2R5B/CPEB1/ANAPC2/SLK/RPS6KA1/ANAPC10/MAPK1/REC8/RPS6KA3/YWHAB/ADCY8/PPP3CB/SMC1A/ITPR3/MAPK3/CDC27/PTTG2/SMC3/CDC26/CALM2/ADCY6/ANAPC5/MAPK11/CDK1/MAPK13/YWHAQ/SMC1B/ANAPC4/ITPR2/YWHAZ/MAPK12/ADCY4/CPEB3/AURKA/CALM1/SPDYE1/ANAPC13/YWHAG/PTTG1/BTRC/ADCY7/MAP2K1/CUL1/CAMK2B/PPP1CA/RPS6KA2/ANAPC11/PKMYT1/YWHAE/FBXO43/IGF1R/MAD2L2/PPP3CA/PPP2R1A/CDC16/PLCZ1/CALML4/PPP2R5A/MAD1L1/SKP1/CALML5/ITPR1/FBXW11/CDK2/RBX1/PRKACB/ADCY9/ADCY3/CCNE2/CALM3/PRKACG/CALML3/CCNE1/CAMK2D/INS/PPP1CC/PPP3CC/PPP2CB/CAMK2A/BUB1/ANAPC16/MOS/PPP1CB/CPEB2/AR/RPS6KA6/CDC23/FBXO5/PPP2R1B/CDC25C/PPP2R5E/PPP3R1/CPEB4/ADCY1/CCNB2/STAG3/ADCY2/YWHAH	111
KEGG	hsa04911	Insulin secretion	74/6408	86/8135	0.05855	0.09096	0.03497	KCNJ11/KCNMB2/KCNU1/SLC2A2/GCG/CAMK2G/KCNN2/PLCB2/ATF4/PRKACA/GNAQ/CREB3/PRKCB/RAB3A/GNA11/CACNA1C/KCNN3/GNAS/ATP1B3/ATF6B/ADCY8/ITPR3/PLCB4/ABCC8/GLP1R/ADCY6/CREB5/CHRM3/ADCY4/PLCB3/RIMS2/ADCY7/GCK/STX1A/CAMK2B/KCNMB3/ATF2/ADCYAP1R1/CACNA1F/VAMP2/CREB3L4/CREB3L2/PRKACB/SLC2A1/CACNA1S/FXYD2/CREB1/PDX1/ADCY9/ATP1A1/ADCY3/PRKACG/CAMK2D/PRKCG/INS/CACNA1D/CAMK2A/KCNN4/RAPGEF4/KCNMB1/PCLO/PLCB1/PRKCA/ADCY1/FFAR1/RYR2/CCK/ATP1A4/ADCYAP1/ADCY2/CREB3L1/ATP1A3/ATP1A2/TRPM4	74
KEGG	hsa02010	ABC transporters	40/6408	45/8135	0.06211	0.09549	0.03672	ABCA3/ABCA12/ABCA2/TAP1/ABCD1/ABCB11/CFTR/ABCB6/ABCC1/ABCC8/ABCA1/ABCA5/ABCA7/ABCB7/ABCC10/ABCD4/TAP2/ABCC5/ABCG1/ABCC4/ABCB8/ABCC3/ABCC2/ABCB10/ABCA9/ABCG5/ABCD3/ABCB5/ABCD2/ABCB9/ABCA4/ABCG4/ABCG2/ABCC12/ABCG8/ABCC9/ABCA8/ABCC11/ABCB1/ABCB4	40
KEGG	hsa04972	Pancreatic secretion	87/6408	102/8135	0.06253	0.09549	0.03672	PNLIP/CPB2/CLCA1/PLA2G2D/CLCA4/CPB1/CELA2A/PLCB2/RAC1/RHOA/GNAQ/PRKCB/ATP2A2/CFTR/GNAS/ATP1B3/ADCY8/SLC9A1/ITPR3/PLCB4/ATP2A3/SLC4A2/KCNQ1/RAB11A/ADCY6/ATP2B2/ATP2B1/RAP1A/ITPR2/CHRM3/ADCY4/PLCB3/RAB3D/PLA2G12A/BST1/CTRL/ADCY7/SLC26A3/AMY1A/AMY1B/AMY1C/AMY2A/CD38/RAP1B/ATP2B3/PLA2G2A/ITPR1/ATP2B4/CPA3/FXYD2/ADCY9/ATP1A1/ADCY3/CELA2B/PRKCG/SLC12A2/CA2/SCT/RAB27B/PLCB1/CELA3B/TPCN2/PRKCA/PRSS2/PRSS3/CELA3A/CLCA2/CTRB1/CTRB2/RAB8A/PLA2G2F/PNLIPRP1/ADCY1/AMY2B/CPA2/SCTR/RYR2/CCK/ATP1A4/ADCY2/SLC4A4/ATP1A3/CPA1/ATP1A2/PLA2G1B/PRSS1/PLA2G12B	87
KEGG	hsa05146	Amoebiasis	87/6408	102/8135	0.06253	0.09549	0.03672	IL12A/SERPINB3/SERPINB4/CD1B/C9/ITGB2/PLCB2/PRKACA/PIK3CB/GNA15/GNAQ/VCL/PRKCB/ACTN1/GNA11/ITGAM/TGFB1/TGFB2/PIK3CD/RAB5A/GNAS/SERPINB6/PLCB4/LAMB1/CASP3/IL10/LAMA3/PIK3R1/LAMA1/IL1B/CD14/LAMA2/ACTN4/PIK3R2/PIK3CA/TNF/CXCL1/ARG2/PLCB3/RAB5B/PTK2/RELA/RAB7A/MUC2/CSF2/NFKB1/IL1R2/HSPB1/CXCL3/PRDX1/TLR2/CD1D/RAB7B/PRKACB/RAB5C/COL4A3/COL4A5/IL12B/SERPINB9/PRKACG/PRKCG/LAMC1/COL4A2/COL1A1/COL4A6/LAMA5/ARG1/PLCB1/C8A/PRKCA/LAMB2/LAMC3/PIK3R3/FN1/IFNG/LAMC2/IL1R1/LAMB4/TLR4/ADCY1/COL4A1/LAMA4/CD1C/IL6/CTSG/GNAL/COL3A1	87
KEGG	hsa05202	Transcriptional misregulation in cancer	161/6408	193/8135	0.06261	0.09549	0.03672	PLAT/MMP3/IGF1/BCL6/SIX1/MEIS1/BCL2A1/MDM2/ZBTB17/GADD45B/CD40/HDAC1/CEBPB/LMO2/AFF1/TFE3/CDK14/ITGAM/FEV/RUNX1/SS18/RXRA/WNT16/SIX4/SPI1/KDM6A/ASPSCR1/CDKN1A/JMJD1C/DDB2/CD14/CSF1R/TLX1/PTCRA/MYCN/ITGB7/BAK1/HOXA10/BAX/BIRC2/HDAC2/BCL2L1/NCOR1/SMAD1/BAIAP3/DDIT3/MITF/ETV4/CCNT2/POLK/MEN1/CDKN1B/RARA/GRIA3/RXRB/CDKN2C/MLLT1/PTK2/PAX3/RELA/EYA1/SUPT3H/NTRK1/PML/KLF3/FLI1/CEBPE/PER2/CSF2/ATM/NFKB1/LDB1/IGF1R/IL1R2/CCNA2/FCGR1A/FLT1/SPINT1/BMI1/GADD45A/ETV6/HHEX/PAX8/TGFBR2/SIN3A/GADD45G/MMP9/CCND2/FOXO1/CD86/IL3/MEF2C/PLAU/TRAF1/NFKBIZ/TMPRSS2/ETV5/DDX5/LYL1/SS18L1/ATF1/HOXA9/DOT1L/NUPR1/TAF15/EWSR1/ELK4/CEBPA/CCNT1/MPO/ETV1/PRCC/TP53/DUSP6/BMP2K/ARNT2/HPGD/GZMB/PBX3/ETV7/ZEB1/BIRC3/PAX5/ERG/DEFA5/SLC45A3/PDGFA/PBX1/IL2RB/RUNX2/RUNX1T1/FLT3/HOXA11/SSX2/SSX2B/BCL11B/TCF3/TLX3/DEFA4/NR4A3/JUP/MLLT3/IGFBP3/DEFA1/DEFA1B/DEFA3/MET/SSX1/MAF/RXRG/MAX/FUS/IL6/PPARG/DEFA6/TSPAN7/FUT8/MYC/HMGA2/ELANE/REL	161
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	24/6408	26/8135	0.06358	0.09653	0.03712	PIGT/PIGS/PIGY/PIGF/PIGN/MPPE1/PIGG/PIGV/PIGQ/PIGC/PIGK/GPAA1/PIGA/PIGB/GPLD1/PIGP/PGAP1/PIGO/PIGH/PIGU/PIGX/PIGM/PIGW/DPM2	24
KEGG	hsa00531	Glycosaminoglycan degradation	18/6408	19/8135	0.06551	0.09856	0.03789	GALNS/HYAL4/GUSB/IDUA/SGSH/GLB1/HGSNAT/HYAL3/HEXB/HYAL1/IDS/HEXA/HYAL2/NAGLU/GNS/SPAM1/HPSE/HPSE2	18
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	18/6408	19/8135	0.06551	0.09856	0.03789	GPT/ACY1/IDH3G/IDH3B/CS/ACO2/NAGS/GOT1L1/BCAT1/GOT1/GOT2/IDH2/BCAT2/IDH1/ACO1/AADAT/GPT2/IDH3A	18
KEGG	hsa04923	Regulation of lipolysis in adipocytes	49/6408	56/8135	0.06917	0.1036	0.03983	NPY1R/AKT2/PRKACA/PIK3CB/PRKG2/PTGS1/NPPA/GNAI1/GNAI3/PIK3CD/PNPLA2/AKT1/GNAS/AKT3/NPR1/ADCY8/IRS2/PLIN1/PIK3R1/ADCY6/PIK3R2/PIK3CA/ABHD5/AQP7/ADCY4/CGA/GNAI2/IRS1/ADCY7/MGLL/PTGS2/ADORA1/PRKACB/IRS4/ADCY9/ADCY3/PRKACG/INSR/ADRB2/INS/PDE3B/PIK3R3/ADRB1/TSHB/ADCY1/PTGER3/PRKG1/ADCY2/TSHR	49
KEGG	hsa00140	Steroid hormone biosynthesis	53/6408	61/8135	0.07568	0.1128	0.04339	CYP7A1/UGT2B4/UGT2A3/AKR1D1/HSD17B2/UGT2B17/CYP7B1/AKR1C4/HSD3B1/HSD17B1/HSD17B7/HSD17B12/HSD3B2/AKR1C2/CYP11B2/STS/LRTOMT/HSD11B1/CYP11A1/CYP1A1/CYP21A2/COMT/SRD5A3/CYP17A1/HSD17B8/CYP3A7/HSD17B6/CYP1B1/SRD5A2/UGT1A10/UGT1A7/UGT1A8/SULT1E1/CYP3A4/UGT2B15/CYP2E1/HSD11B2/AKR1C3/CYP11B1/SRD5A1/HSD17B3/CYP1A2/CYP19A1/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/SULT2B1/CYP3A5/UGT2A1/UGT2A2	53
KEGG	hsa00061	Fatty acid biosynthesis	17/6408	18/8135	0.07954	0.1175	0.04519	ACSL3/MECR/CBR4/ACSBG2/OXSM/MCAT/ACSL4/ACSF3/OLAH/ACSL1/FASN/HSD17B8/ACACA/ACSL5/ACSBG1/ACSL6/ACACB	17
KEGG	hsa00511	Other glycan degradation	17/6408	18/8135	0.07954	0.1175	0.04519	GBA2/MAN2B2/MANBA/FUCA2/GLB1/NEU2/AGA/GBA/HEXB/MAN2B1/ENGASE/HEXA/NEU1/MAN2C1/NEU4/FUCA1/NEU3	17
KEGG	hsa04710	Circadian rhythm	28/6408	31/8135	0.07995	0.1176	0.04523	CLOCK/CSNK1E/CSNK1D/PRKAB1/CRY2/BHLHE41/BHLHE40/PRKAG1/PRKAG2/PRKAA1/BTRC/CUL1/ARNTL/PER2/RORC/PER1/SKP1/FBXW11/RBX1/NPAS2/CREB1/NR1D1/CRY1/FBXL3/RORB/PRKAG3/PRKAA2/PRKAB2	28
KEGG	hsa04540	Gap junction	75/6408	88/8135	0.08325	0.122	0.04689	HTR2C/GRB2/TUBA1A/TUBA1C/PLCB2/PRKACA/PRKG2/GNAQ/MAP2K5/PRKCB/SOS1/CSNK1D/MAP2K2/GNA11/GNAI1/GNAI3/MAPK1/TUBAL3/GNAS/PDGFRB/ADCY8/TUBA3D/TUBA3E/TUBA4A/ITPR3/PLCB4/TUBA3C/RAF1/TUBB1/MAPK3/ADCY6/TUBA1B/CDK1/HRAS/GUCY1A2/ITPR2/ADCY4/HTR2A/MAPK7/GNAI2/PLCB3/HTR2B/DRD1/ADCY7/MAP2K1/LPAR1/SOS2/TUBA8/ITPR1/KRAS/PDGFD/MAP3K2/TUBB6/PRKACB/EGF/ADCY9/PDGFB/ADCY3/PRKACG/PDGFC/SRC/PRKCG/DRD2/TUBB/GJD2/PDGFA/PLCB1/TUBB3/PRKCA/NRAS/ADRB1/ADCY1/PRKG1/PDGFRA/ADCY2	75
KEGG	hsa05416	Viral myocarditis	52/6408	60/8135	0.0848	0.1237	0.04756	HLA-E/ITGB2/ACTG1/CASP9/RAC1/CD40/HLA-B/RAC2/HLA-C/EIF4G2/CCND1/CD55/ITGAL/HLA-A/FYN/CASP3/LAMA1/CASP8/LAMA2/DAG1/ACTB/BID/ABL2/HLA-G/ICAM1/HLA-F/HLA-DMB/SGCB/MYH6/EIF4G1/ABL1/EIF4G3/CYCS/CD86/HLA-DMA/CD40LG/SGCG/HLA-DRA/MYH7/HLA-DPA1/CD80/PRF1/HLA-DOA/HLA-DQB1/CD28/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4	52
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	22/6408	24/8135	0.08928	0.1297	0.04985	HS3ST3A1/HS6ST2/HS3ST2/HS3ST5/HS6ST3/EXT1/B4GALT7/NDST2/B3GAT3/XYLT2/NDST1/NDST3/EXTL1/HS6ST1/NDST4/B3GALT6/EXTL3/HS3ST1/HS2ST1/HS3ST3B1/XYLT1/EXT2	22
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	27/6408	30/8135	0.09306	0.1346	0.05174	HAO1/GLYCTK/GCSH/GLUL/DLD/MDH1/MDH2/AFMID/ACSS2/PCCA/HYI/CS/CAT/PGP/ACO2/GRHPR/ACAT1/PCCB/MCEE/AMT/ACSS1/SHMT2/ACAT2/ACO1/AGXT/SHMT1/HAO2	27
KEGG	hsa05219	Bladder cancer	36/6408	41/8135	0.1054	0.1511	0.05809	E2F1/MDM2/UPK3A/CCND1/MAP2K2/ARAF/MAPK1/BRAF/RAF1/MAPK3/CDKN1A/THBS1/DAPK3/HRAS/MAP2K1/VEGFA/CDKN2A/E2F3/DAPK2/MMP9/TYMP/RASSF1/KRAS/EGF/MMP2/SRC/RPS6KA5/CDK4/TP53/RB1/NRAS/MMP1/E2F2/HBEGF/DAPK1/MYC	36
KEGG	hsa04614	Renin-angiotensin system	21/6408	23/8135	0.1054	0.1511	0.05809	MAS1/PRCP/ATP6AP2/CTSA/KLK1/REN/CMA1/AGTR2/MME/AGTR1/ANPEP/NLN/CPA3/KLK2/LNPEP/ENPEP/ACE/PREP/ACE2/THOP1/CTSG	21
KEGG	hsa00480	Glutathione metabolism	50/6408	58/8135	0.1059	0.1511	0.05811	GPX5/OPLAH/GGT7/GSTK1/MGST3/SMS/GSTA3/GGT1/GSS/SRM/GSTO1/GGCT/NAT8B/G6PD/CHAC2/PGD/GCLM/GSTT1/ANPEP/TXNDC12/ODC1/RRM2B/RRM1/GPX4/GSTO2/IDH2/IDH1/GPX7/MGST1/GSTP1/GPX2/GSTT2/GGT5/GSR/GSTM3/GSTM4/MGST2/LANCL1/GSTM1/PRDX6/LAP3/RRM2/GCLC/GSTM2/GPX1/GSTA1/GGT6/CHAC1/GSTM5/GPX8	50
KEGG	hsa04744	Phototransduction	26/6408	29/8135	0.108	0.1536	0.05905	GRK7/CNGA1/PDE6A/GNB1/CALML6/SAG/PDE6G/GNAT1/GUCA1A/GUCY2D/GUCA1B/CALM2/CNGB1/RGS9/CALM1/CALML4/CALML5/GNGT1/CALM3/SLC24A1/CALML3/GRK1/GUCY2F/PDE6B/GUCA1C/RCVRN	26
KEGG	hsa05033	Nicotine addiction	35/6408	40/8135	0.1196	0.1692	0.06506	GABRA6/GABRG2/GRIA2/SLC17A8/GABRE/GABRR1/GABRA4/GABRA2/SLC17A7/GABRB1/CHRNA4/SLC32A1/CHRNB2/GRIN2B/GRIA3/GABRP/GRIN2C/GRIN1/GABRA1/CHRNA7/GRIN2D/GRIA4/CACNA1B/GABRA3/SLC17A6/GABRG1/GRIN3B/GABRD/GABRA5/GABRG3/GRIN2A/GRIA1/GABRB3/GRIN3A/GABRR3	35
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	84/6408	100/8135	0.1203	0.1695	0.06516	IL2/CCL25/XCR1/TNFRSF14/IL10RA/IL2RG/IL20/TNFRSF1B/CCL14/CCL15/CXCR1/LTBR/TNFRSF10C/IL22RA1/TNFRSF10D/TNFRSF1A/IL6R/IL10/CCR1/IL2RA/CSF1R/TNFRSF10B/IL34/CXCR3/TNF/CCR2/CCL28/CXCL1/IL6ST/TNFSF10/IL10RB/CXCR4/CCL24/IL20RA/CCL19/CXCR2/IL18RAP/CXCL3/CCL27/TNFRSF10A/IL19/CX3CR1/CXCL13/CCL26/LTA/CCL21/TNFSF14/IL20RB/CCL4/CCL5/CCL1/CXCR5/CCR7/IL18/PPBP/IL18R1/CCL7/CCL23/CXCL11/IL2RB/CCL18/CCR10/CCL20/CCL16/CXCL6/CCL13/CCL2/PF4V1/XCL1/XCL2/CCL17/CSF1/CXCL14/CCR4/CCL3/CCL3L1/CCL3L3/CXCL5/CCL11/PF4/IL24/IL6/CXCL12/CCR6	84
KEGG	hsa00340	Histidine metabolism	20/6408	22/8135	0.1241	0.1741	0.06696	CNDP1/ASPA/ALDH9A1/FTCD/HNMT/ALDH2/ALDH3B1/ALDH1B1/HAL/UROC1/ALDH7A1/HDC/MAOA/CNDP2/ALDH3A2/CARNS1/ALDH3A1/AMDHD1/ALDH3B2/MAOB	20
KEGG	hsa04350	TGF-beta signaling pathway	79/6408	94/8135	0.1274	0.1774	0.06819	GREM1/PITX2/RGMA/PPP2CA/RHOA/RPS6KB2/TGFB1/TGFB2/ZFYVE16/SMAD2/MAPK1/ZFYVE9/EP300/SMAD4/BMP8A/SMURF2/MAPK3/ROCK1/THBS1/SMAD3/AMH/ACVR2B/BMP7/SMAD1/TNF/ID3/BAMBI/SMURF1/SMAD9/NBL1/CUL1/INHBB/HAMP/BMP6/AMHR2/PPP2R1A/ACVR1/E2F4/SMAD6/CDKN2B/TGFBR2/ACVR1B/SKP1/TGIF2/CHRD/RBX1/LTBP1/LEFTY2/SMAD5/TGFBR1/GDF5/GREM2/INHBE/RPS6KB1/PPP2CB/FST/TGIF1/THSD4/BMPR2/RGMB/BMPR1B/DCN/NODAL/RBL1/PPP2R1B/CREBBP/IFNG/ACVR2A/INHBC/BMPR1A/ID4/BMP5/BMP8B/LEFTY1/E2F5/FBN1/MYC/NEO1/INHBA	79
KEGG	hsa04721	Synaptic vesicle cycle	66/6408	78/8135	0.1274	0.1774	0.06819	SLC17A8/SLC6A1/ATP6V1H/SLC17A7/NSF/ATP6V0D1/ATP6V0A1/RAB3A/CLTC/STX3/ATP6V0E1/ATP6V1B2/ATP6V0B/SLC32A1/ATP6V1E2/CPLX3/SLC6A11/ATP6V1E1/ATP6V1D/AP2A2/TCIRG1/CLTCL1/AP2M1/ATP6V1B1/ATP6V1F/ATP6V1C1/CLTA/DNM1/CLTB/STX1A/SLC1A1/DNM2/ATP6V0E2/ATP6V0A2/SYT1/ATP6V0C/ATP6V1A/RIMS1/ATP6V0D2/SLC6A7/VAMP2/SLC6A2/SLC1A7/AP2S1/ATP6V1G3/AP2A1/AP2B1/STX2/CPLX1/SLC1A3/NAPA/CACNA1B/CPLX2/SLC18A2/SLC1A6/SLC17A6/SLC6A5/ATP6V1G2/SLC6A12/SLC18A1/STX1B/SLC18A3/SLC6A9/SLC6A3/ATP6V0A4/DNM3	66
KEGG	hsa04512	ECM-receptor interaction	74/6408	88/8135	0.1351	0.1872	0.072	COL6A6/FREM2/TNN/ITGA11/NPNT/ITGA5/ITGB4/DSPP/ITGA2/THBS4/CD47/GP9/HSPG2/VWF/LAMB1/GP6/LAMA3/LAMA1/ITGA2B/VTN/LAMA2/THBS1/ITGB7/DAG1/TNXB/SV2B/THBS3/ITGA8/COL6A1/CD36/ITGB5/GP5/ITGA9/ITGAV/GP1BB/COL9A3/GP1BA/ITGA7/ITGA10/COL9A1/ITGA4/SDC4/ITGB3/COL4A3/CD44/COL4A5/AGRN/DMP1/SV2C/COL9A2/ITGB1/COMP/LAMC1/COL4A2/THBS2/COL1A1/COL4A6/SDC1/CHAD/LAMA5/COL6A3/LAMB2/ITGB8/LAMC3/FN1/LAMC2/LAMB4/SV2A/FREM1/COL4A1/LAMA4/ITGA3/COL6A2/SPP1	74
KEGG	hsa05100	Bacterial invasion of epithelial cells	65/6408	77/8135	0.1394	0.1924	0.07399	ACTG1/RAC1/PIK3CB/ITGA5/SHC1/RHOA/ARPC4/ARPC5/PXN/CTNNA1/VCL/ILK/RHOG/CLTC/ARPC1A/ARHGAP10/ARPC1B/ACTR3B/ARPC2/PIK3CD/ELMO2/ACTR3/SHC3/WASL/CRKL/HCLS1/ARPC5L/ARPC3/BCAR1/PIK3R1/CLTCL1/ACTB/PIK3R2/PIK3CA/CD2AP/CDC42/CLTA/DNM1/CLTB/PTK2/DNM2/ELMO3/MAD2L2/CRK/ELMO1/CBL/ITGB1/SRC/CTTN/CTNNA2/CTNNA3/ACTR2/CTNNB1/WASF2/SHC2/CAV2/SHC4/PIK3R3/FN1/DOCK1/GAB1/MET/DNM3/CAV3/WASF1	65
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	14/6408	15/8135	0.1404	0.193	0.0742	B4GALNT1/ST8SIA5/B3GALT4/ST3GAL1/SLC33A1/GLB1/HEXB/HEXA/ST3GAL2/ST6GALNAC6/ST6GALNAC5/ST6GALNAC4/ST3GAL5/ST6GALNAC3	14
KEGG	hsa04514	Cell adhesion molecules	123/6408	149/8135	0.1493	0.2043	0.07855	CDH5/NCAM2/HLA-E/CLDN8/NLGN1/ITGB2/CD40/CADM3/HLA-B/HLA-C/SELPLG/CD276/CLDN1/ITGAM/PDCD1/CLDN3/ICAM3/F11R/ALCAM/CD4/CDH2/ITGAL/HLA-A/CADM1/NRXN3/CD99/CLDN5/SPN/ITGB7/CD58/LRRC4/VCAN/CD226/CLDN15/SELL/ICAM2/NTNG2/NLGN2/HLA-G/ITGA8/ESAM/ICAM1/CD99L2/CDH4/NFASC/CDH3/SELP/HLA-F/PTPRC/CLDN19/HLA-DMB/CDH15/CD6/CD34/ITGA9/ITGAV/CLDN9/CLDN2/VTCN1/PECAM1/SELE/CLDN6/MAG/PVR/PTPRM/ICOS/CLDN23/CD86/CD2/JAM3/ITGA4/HLA-DMA/NRCAM/SDC2/SDC4/MPZ/NRXN1/CD274/TIGIT/NRXN2/CLDN4/CNTNAP2/CD40LG/CTLA4/HLA-DRA/ITGB1/JAM2/NLGN4Y/HLA-DPA1/CD80/SDC3/SIGLEC1/ICOSLG/CLDN11/SDC1/CLDN7/NLGN4X/HLA-DOA/HLA-DQB1/IGSF11/CD28/ITGB8/CD8B/L1CAM/CLDN16/MADCAM1/VCAM1/NLGN3/CD22/HLA-DOB/PTPRF/HLA-DQA1/HLA-DQA2/GLG1/CNTNAP1/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/CLDN17/CNTN1/NEO1/CLDN14	123
KEGG	hsa04672	Intestinal immune network for IgA production	42/6408	49/8135	0.1539	0.209	0.08037	IL2/CCL25/CD40/LTBR/TGFB1/IL10/TNFSF13/ITGB7/CCL28/CXCR4/HLA-DMB/TNFRSF13B/TNFSF13B/ICOS/CD86/IL4/ITGA4/HLA-DMA/CD40LG/HLA-DRA/MAP3K14/HLA-DPA1/CD80/ICOSLG/HLA-DOA/HLA-DQB1/CD28/MADCAM1/IL15/CCR10/IL15RA/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/IL6/CXCL12/AICDA/TNFRSF13C	42
KEGG	hsa00230	Purine metabolism	106/6408	128/8135	0.154	0.209	0.08037	PRPS1L1/NT5C1B/PDE8A/ENTPD3/ENTPD4/PDE6A/PDE1A/ENTPD2/DGUOK/PDE6G/ADSL/PDE4B/PDE6D/NT5C2/PGM1/NPR1/ADCY8/ITPA/GUCY2D/NT5C/GMPR2/GMPS/PDE1B/PDE4D/ADCY6/NUDT16/PFAS/NUDT5/AMPD2/GUCY1A2/AK2/NME1-NME2/NME2/NT5M/ADCY4/ENTPD1/PDE11A/PRPS2/AMPD3/IMPDH1/ATIC/ADCY7/AK1/NT5DC4/NME4/XDH/NME3/ENTPD5/PDE6C/ENTPD6/HPRT1/AMPD1/APRT/NME6/HDDC3/PAPSS2/CANT1/PDE3A/GMPR/RRM2B/PNP/NPR2/PDE2A/PAICS/RRM1/ADCY9/AK7/NUDT2/HDDC2/ADK/ADCY3/PDE7A/GUK1/PAPSS1/PDE10A/AK3/PDE7B/GDA/ENPP3/GUCY2F/PDE4C/NME1/ADA/AK5/ENPP4/RRM2/NUDT9/PDE6B/PDE9A/FHIT/PDE3B/IMPDH2/PRPS1/ALLC/PDE4A/ADCY1/PGM2/NME7/PDE6H/PDE8B/ENPP1/ADCY2/GART/PPAT/PDE1C/PDE5A	106
KEGG	hsa04136	Autophagy - other	28/6408	32/8135	0.16	0.2154	0.08283	PIK3C3/PPP2CA/RPTOR/PIK3R4/WIPI2/GABARAP/ATG5/MLST8/MTOR/ATG12/ATG4A/ATG4D/ATG9A/ATG7/ATG3/GABARAPL1/GABARAPL2/ATG4B/BECN1/ATG2B/IGBP1/ATG2A/ULK2/WIPI1/ATG9B/PPP2CB/ATG4C/ATG10	28
KEGG	hsa04215	Apoptosis - multiple species	28/6408	32/8135	0.16	0.2154	0.08283	BCL2L11/CASP9/HTRA2/TNFRSF1A/FADD/MAPK9/CASP3/CASP8/BAK1/BAX/BIRC2/BBC3/BID/BCL2L1/BIRC6/BECN1/XIAP/DIABLO/APAF1/BIRC7/CYCS/MAPK8/CASP7/PMAIP1/BIRC3/BCL2/MAPK10/BOK	28
KEGG	hsa00860	Porphyrin metabolism	37/6408	43/8135	0.1628	0.2184	0.08397	UGT2B4/UGT2A3/UGT2B17/GUSB/PPOX/FXN/HMOX2/ALAD/COX15/UROD/BLVRA/ALAS1/UROS/CP/COX10/EARS2/HMBS/CPOX/UGT1A10/UGT1A7/UGT1A8/UGT2B15/HEPH/MMAB/BLVRB/HCCS/HMOX1/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/FECH/ALAS2/UGT2A1/UGT2A2	37
KEGG	hsa05168	Herpes simplex virus 1 infection	399/6408	495/8135	0.1652	0.2207	0.08486	IL12A/IFNA2/IFNB1/ZNF480/ZNF560/ZNF99/ZIM3/ZNF114/IFNA1/IFNA13/HLA-E/ZNF221/ZNF584/ZNF74/ZNF566/BAD/ZNF225/AKT2/TAPBP/ZNF304/ZNF34/CASP9/ZNF613/ZNF383/IFNGR2/PIK3CB/ITGA5/TNFRSF14/ZNF214/SYK/HLA-B/ZNF707/HLA-C/EIF2B4/ZNF700/TSC1/ZNF471/ZNF562/CARD9/CFP/MYD88/ZNF565/ZNF155/EIF2B2/TAP1/ZNF93/IKBKG/ZNF564/ZNF782/ZNF701/TYK2/ZNF41/ZNF230/ZNF567/ZNF135/TBK1/NXF1/PIK3CD/IRAK1/ZNF124/IFNAR1/TNFRSF1A/ZNF57/EIF2B3/ZNF44/ZNF250/TLR9/MTOR/TSC2/AKT1/TRADD/DAXX/ZNF212/ZNF268/AKT3/ZNF180/ZNF317/ZNF184/POU2F2/FADD/EIF2B1/HLA-A/ZNF79/TICAM1/ZNF267/FAS/CASP3/ZNF224/ZNF559/EIF2S1/ZNF680/ZNF777/JAK2/RHEB/PIK3R1/ZNF205/ZNF764/CASP8/ZNF416/ZNF555/EIF2B5/POU2F1/IL1B/ZNF227/IRAK4/TRAF6/ZNF25/ZNF273/ZNF768/ZNF557/IFNGR1/TRAF2/MAVS/BAK1/IRF3/ZNF43/ZNF316/ZNF175/NFKBIA/ZNF133/EIF4EBP1/BAX/BIRC2/BID/ZNF211/ZNF101/PIK3R2/BCL2L1/ZNF282/IKBKB/ZNF823/ZNF669/RNASEL/PIK3CA/TAB2/IRF9/ZNF766/TNF/ZNF544/ZNF222/ZNF33A/ZNF350/ZNF671/ZNF563/EIF2AK1/ZNF846/ZNF200/ZNF620/ZNF354C/ZNF20/SRPK1/ZNF763/HLA-G/IRF7/ZNF561/ZNF85/ZNF786/ZNF169/ZNF558/HLA-F/ZNF45/ZNF398/STAT1/EIF2AK3/PILRA/ZNF461/ZNF226/ZNF12/ZNF585A/MAP3K7/ZNF616/HLA-DMB/STAT2/ZNF713/RELA/ZNF136/ZNF836/ZNF528/ZNF334/TAB1/ZNF552/C3/ZNF19/PPP1CA/ZNF780B/ZNF506/ZNF251/TAP2/PML/DDX58/ZNF7/ZNF354A/IFNA8/HCFC1/ZNF736/NXF2/NXF2B/NFKB1/ZNF419/ZNF689/ZNF333/TRAF3/IKBKE/ZNF141/APAF1/ZNF337/SP100/ZNF443/IFIH1/ZNF780A/TLR2/C5/ZNF649/ZNF256/ZNF436/ZNF17/ZNF439/PILRB/ZNF551/CYCS/HCFC2/ZNF569/ZNF490/EIF2AK2/ZNF432/ZNF26/ZNF721/ZNF621/HLA-DMA/ZNF688/ZNF605/ZNF286A/ZNF793/ZNF14/CD74/ZNF140/ITGB3/ZNF107/ZNF791/ZNF783/ZNF254/ZNF189/LTA/ZNF182/B2M/ZNF658/ZNF3/ZNF420/IL12B/SOCS3/IFNAR2/ZNF8/ZNF404/ZNF23/ZNF568/ZNF627/ZNF343/ZNF324/ZNF233/ZNF746/ZNF805/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/TNFSF14/ZNF611/ZNF177/HLA-DRA/ZNF160/IFNA16/ZNF320/ZNF577/CALR/SRC/ZIK1/ZNF540/RBAK/PTPN11/CCL5/ZNF879/PPP1CC/ZNF492/ZNF253/ZNF84/ZNF440/HLA-DPA1/ZNF10/TP53/ZFP90/ZNF486/ZNF675/ZNF641/ZNF606/OAS1/ZNF614/ZNF554/ZNF624/ZNF30/PDIA3/ZNF597/ZNF83/ZNF670/BIRC3/ZNF599/ZNF765/ZNF615/ZNF331/ZNF90/ZNF529/ZNF630/ZNF595/PPP1CB/ZNF248/HLA-DOA/ZNF619/ZNF682/HLA-DQB1/TRAF5/OAS3/ZNF324B/ZNF813/ZNF684/ZNF473/ZNF573/ZNF91/ZNF302/BCL2/ZNF792/CHUK/ZFP1/JAK1/FASLG/ZNF33B/ZNF81/ZNF600/PIK3R3/ZNF484/ZNF425/IFNG/ZNF853/ZNF527/ZNF235/CCL2/ZNF234/ZNF550/ZNF785/BST2/ZNF479/ZNF665/ZNF284/ZNF556/ZNF778/ZFP28/ZNF587/ZNF311/HLA-DOB/ZNF442/IFNA17/ZFP37/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/ZNF589/ZNF100/ZNF460/OAS2/ZNF709/HLA-DRB1/HLA-DRB4/ZNF285/ZFP82/ZNF708/ZNF223/ZNF468/ZNF208/ZNF829/ZNF157/IL6/ZNF749/ZFP57/EIF2AK4/ZNF77/ZNF582/ZNF571/ZNF610/ZNF607/ZNF549/POU2F3/ZNF530/ZNF37A/ZNF674/ZNF2/ZNF583/ZNF662	399
KEGG	hsa00670	One carbon pool by folate	18/6408	20/8135	0.1705	0.2268	0.08721	MTHFR/MTHFD2L/FTCD/ALDH1L1/MTHFD2/MTHFD1/MTR/ATIC/DHFR/MTFMT/MTHFD1L/AMT/MTHFS/SHMT2/ALDH1L2/TYMS/SHMT1/GART	18
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	32/6408	37/8135	0.1721	0.2272	0.08735	AGXT2/ASPA/GPT/RIMKLB/ADSL/GLS/GLUL/ASL/ALDH4A1/ASNS/CAD/NIT2/NAT8L/IL4I1/GFPT2/ABAT/GOT1L1/DDO/GLUD1/GOT1/GOT2/GFPT1/ASRGL1/GPT2/AGXT/GAD2/GLUD2/GLS2/GAD1/ALDH5A1/PPAT/RIMKLA	32
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	32/6408	37/8135	0.1721	0.2272	0.08735	IGF1/PIK3CB/PRKCB/PIK3CD/SFN/MAPK1/ATP1B3/MAPK3/PIK3R1/PIK3R2/PIK3CA/IRS1/SCNN1A/KCNJ1/SCNN1B/KRAS/FXYD2/ATP1A1/INSR/PRKCG/INS/NEDD4L/NR3C2/PRKCA/PIK3R3/HSD11B2/PDPK1/SCNN1G/ATP1A4/SGK1/ATP1A3/ATP1A2	32
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	58/6408	69/8135	0.1768	0.2325	0.08941	UGT2B4/UGT2A3/CYP2A7/CYP2C19/NAT2/UGT2B17/GSTK1/SULT1A3/SULT1A4/MGST3/GSTA3/SULT1A2/NAT1/GSTO1/AKR1C2/SULT2A1/EPHX1/HSD11B1/GSTT1/CYP2C18/CYP1A1/SULT1A1/PTGS2/GSTO2/CBR1/CYP2C9/CYP3A7/CYP1B1/MGST1/GSTP1/UGT1A10/UGT1A7/UGT1A8/GSTT2/CYP2C8/GSTM3/GSTM4/MGST2/GSTM1/CYP2A6/CYP3A4/GSTM2/UGT2B15/CYP2E1/GSTA1/CYP1A2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/CYP2A13/CYP3A5/GSTM5/CYP3A43/UGT2A1/UGT2A2	58
KEGG	hsa05310	Asthma	27/6408	31/8135	0.1816	0.2378	0.09144	EPX/CD40/IL10/FCER1G/TNF/HLA-DMB/IL3/IL4/HLA-DMA/CD40LG/IL13/HLA-DRA/HLA-DPA1/HLA-DOA/HLA-DQB1/PRG2/RNASE3/FCER1A/IL9/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/CCL11	27
KEGG	hsa03450	Non-homologous end-joining	12/6408	13/8135	0.2022	0.2638	0.1014	XRCC5/DCLRE1C/FEN1/NHEJ1/XRCC6/RAD50/POLL/POLM/LIG4/PRKDC/DNTT/XRCC4	12
KEGG	hsa05415	Diabetic cardiomyopathy	165/6408	203/8135	0.2139	0.278	0.1069	GYS2/SLC25A31/COX6A2/COX8C/COX7B2/COX4I2/NDUFS7/UQCRB/UQCRQ/COX5B/NDUFS1/NDUFC1/AKT2/NDUFB3/NDUFA1/PPARA/NDUFS2/CAMK2G/PLCB2/RAC1/MAPK14/PIK3CB/COX6B1/RAC2/PRKCB/COX8A/ATP2A2/NDUFB10/NDUFA4/GAPDH/NDUFV2/SLC25A4/NCF4/UQCRFS1/TGFB1/VDAC2/TGFB2/NCF1/NDUFB4/NDUFA10/PIK3CD/NDUFB2/UQCR10/PDHA2/NCF2/SMAD2/NDUFB11/MTOR/AKT1/UQCRH/AKT3/COX7B/SDHA/COX7A2/NDUFB6/NDUFB8/PPIF/PTEN/UQCRC2/MAPK9/PLCB4/ATP2A3/NOS3/PDK3/NDUFA7/CPT2/NDUFA2/COX6C/NDUFC2/PIK3R1/VDAC3/NDUFA6/MAPK11/PARP1/REN/NDUFS8/NDUFB1/SMAD3/PDHB/MAPK13/NDUFA12/NDUFS3/PIK3R2/PLN/COX4I1/CYC1/PIK3CA/CMA1/CPT1B/G6PD/UQCR11/MAPK12/NDUFA9/NDUFS4/SLC25A5/SDHB/COX6B2/PLCB3/NDUFA11/CD36/PDHA1/NDUFV1/NDUFB5/NDUFAB1/IRS1/SDHC/PRKCZ/RELA/CTSD/GYS1/CAMK2B/COX5A/CYBA/AGTR1/NDUFS6/PPP1CA/NDUFA3/NDUFB9/COX6A1/NFKB1/PDK2/PRKCD/CYBB/NDUFS5/COX7C/GFPT2/TGFBR2/MMP9/NDUFA8/SLC2A1/MAPK8/NDUFA13/AGER/TGFBR1/COX7A2L/NDUFA5/MMP2/GFPT1/INSR/CAMK2D/PRKCG/INS/PPP1CC/NDUFV3/SDHD/CAMK2A/COL1A1/GSR/PPP1CB/ACE/PLCB1/PRKCA/PIK3R3/MAPK10/UQCRC1/NDUFB7/SLC25A6/PDK4/RYR2/VDAC1/SLC2A4/NDUFA4L2/GSK3B/TBC1D4/COL3A1	165
KEGG	hsa01240	Biosynthesis of cofactors	125/6408	153/8135	0.2155	0.2789	0.1072	UGT2B4/UGT2A3/PPCS/TDO2/UGT2B17/ALPP/DHODH/COASY/VKORC1/PANK2/COQ7/MPI/NFS1/GUSB/ADSL/PPCDC/PMM1/COQ2/PDXP/PPOX/MAT2A/DLD/AKR1A1/HAAO/NADK/PDXK/AFMID/UGP2/GMPPA/FLAD1/GSS/GMPPB/MTHFD2L/NQO1/ALAD/COX15/RDH11/AK2/NME1-NME2/NME2/CAD/OXSM/UROD/MTHFD2/COQ5/ALDH2/GCLM/MTHFD1/PMM2/SPR/ALDH1B1/AK1/DHFR/NADSYN1/NME4/COQ6/MTHFD1L/VKORC1L1/NME3/DHRS3/ALAS1/ALPL/UROS/NME6/GGCX/RDH12/TPK1/LIPT1/RFK/ASPDH/CTPS2/COX10/SHMT2/BCAT1/ALDH3A2/GGH/EARS2/AK7/HMBS/BCAT2/KYNU/HSD17B6/NMNAT1/CPOX/NMNAT3/COQ3/UMPS/UGT1A10/UGT1A7/UGT1A8/MAT2B/RGN/AK3/ALPI/QPRT/NME1/AK5/NMNAT2/RDH13/KMO/GCLC/CMPK2/PTS/UGT2B15/SHMT1/LIAS/SDR16C5/IDO1/MMAB/PNPO/GCH1/MOCS2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/NME7/FECH/ALAS2/PANK1/UGT2A1/UGT2A2/GPHN	125
KEGG	hsa01230	Biosynthesis of amino acids	62/6408	75/8135	0.2507	0.322	0.1238	ALDOB/TKTL2/PRPS1L1/PGAM1/PGK1/PHGDH/OTC/TPI1/GPT/ACY1/TALDO1/GAPDH/IDH3G/ENO1/SDS/PGAM2/ENO3/GLUL/MAT2A/ASL/PGK2/PFKP/PYCR2/ALDOA/TKT/IDH3B/CS/ASNS/ACO2/ALDH18A1/ARG2/PRPS2/MTR/ALDOC/ENO2/NAGS/PC/PYCR1/PFKM/PFKL/GOT1L1/PKLR/SHMT2/RPE/BCAT1/GOT1/GOT2/IDH2/BCAT2/IDH1/ACO1/PAH/MAT2B/CBS/GPT2/ARG1/PRPS1/SHMT1/IDH3A/RPIA/TKTL1/SDSL	62
KEGG	hsa04918	Thyroid hormone synthesis	62/6408	75/8135	0.2507	0.322	0.1238	IYD/GPX5/PLCB2/ATF4/PRKACA/GNAQ/CREB3/PRKCB/HSPA5/HSP90B1/TTF1/GNAS/ATP1B3/SERPINA7/ATF6B/ADCY8/ITPR3/PLCB4/PDIA4/ADCY6/CREB5/ITPR2/ADCY4/CGA/PLCB3/ADCY7/ASGR2/CANX/PAX8/DUOXA2/ATF2/ITPR1/CREB3L4/CREB3L2/PRKACB/FXYD2/CREB1/ADCY9/DUOX1/TTR/ATP1A1/ADCY3/GPX7/PRKACG/GPX2/PRKCG/GSR/PLCB1/PRKCA/SLC26A4/TSHB/GPX1/ASGR1/ADCY1/ATP1A4/ADCY2/CREB3L1/ATP1A3/TSHR/ATP1A2/LRP2/GPX8	62
KEGG	hsa05410	Hypertrophic cardiomyopathy	74/6408	90/8135	0.254	0.3251	0.125	ACTC1/ITGA11/IGF1/CACNB3/ACTG1/ITGA5/CACNB1/ITGB4/ATP2A2/ITGA2/CACNA1C/TGFB1/TGFB2/EMD/PRKAB1/TPM3/ATP2A3/MYBPC3/LAMA1/ITGA2B/CACNG1/LAMA2/TNNT2/ITGB7/DAG1/ACTB/CACNA2D1/PRKAG1/CACNG8/TNF/CACNA2D4/PRKAG2/TNNC1/ITGA8/LMNA/ITGB5/PRKAA1/TPM4/SGCB/MYH6/ITGA9/ITGAV/CACNA2D2/ITGA7/EDN1/CACNA1F/ITGA10/ITGA4/TTN/CACNA1S/ITGB3/SLC8A3/SGCG/ITGB1/SLC8A1/MYH7/CACNB2/CACNA1D/CACNG4/CACNG3/ACE/TPM1/ITGB8/MYL3/DES/TPM2/PRKAG3/RYR2/ITGA3/PRKAA2/IL6/CACNG5/PRKAB2/CACNG2	74
KEGG	hsa04217	Necroptosis	129/6408	159/8135	0.2655	0.3385	0.1301	IFNA2/IFNB1/IL33/SLC25A31/IFNA1/IFNA13/CHMP4A/VPS4A/CAMK2G/HMGB1/IFNGR2/FTH1/STAT5B/STAT6/CFLAR/PLA2G4D/RIPK1/STAT5A/VPS4B/MLKL/SPATA2/RIPK3/SLC25A4/TYK2/VDAC2/IFNAR1/TNFRSF1A/PPIA/CHMP2A/PLA2G4C/TRADD/PGAM5/JAK3/TNFAIP3/GLUL/FADD/SQSTM1/MAPK9/CHMP4B/RBCK1/TICAM1/CHMP6/FAS/CYLD/JAK2/PYGL/USP21/SPATA2L/CASP8/VDAC3/CHMP1A/IL1B/PARP1/PYCARD/IFNGR1/SMPD1/TRAF2/BAX/BIRC2/TNFRSF10B/BID/CAPN2/JMJD7-PLA2G4B/PLA2G4B/IRF9/TNF/RNF31/CASP1/SLC25A5/PYGM/XIAP/CHMP2B/TNFSF10/PPID/FAF1/STAT1/STAT2/CAMK2B/PLA2G4F/PYGB/IFNA8/NLRP3/HSP90AA1/CYBB/TRPM7/CHMP5/AIFM1/EIF2AK2/GLUD1/FTL/TNFRSF10A/TICAM2/MAPK8/IFNAR2/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/HSP90AB1/CAMK2D/DNM1L/STAT4/STAT3/CHMP7/CAMK2A/ALOX15/SHARPIN/ZBP1/CAPN1/BIRC3/TRAF5/BCL2/JAK1/FASLG/GLUD2/PLA2G4A/IFNG/MAPK10/TLR4/CHMP1B/CHMP4C/SLC25A6/IFNA17/VDAC1/IL1A	129
KEGG	hsa00910	Nitrogen metabolism	15/6408	17/8135	0.2673	0.3394	0.1305	CA5B/GLUL/CA14/CA4/GLUD1/CA6/CA12/CA5A/CA2/CA9/CA13/CA7/GLUD2/CA8/CA1	15
KEGG	hsa00051	Fructose and mannose metabolism	28/6408	33/8135	0.2688	0.3401	0.1308	ALDOB/TPI1/FBP1/MPI/HK3/PMM1/SORD/PFKFB4/GMDS/PFKP/GMPPA/ALDOA/GMPPB/HK1/KHK/PMM2/PFKFB3/HKDC1/ALDOC/PFKM/PFKFB2/PFKL/TSTA3/FPGT/AKR1B1/HK2/AKR1B10/FBP2	28
KEGG	hsa03010	Ribosome	128/6408	158/8135	0.279	0.3517	0.1352	MRPL34/MRPL33/RPL35A/MRPS5/RPL26/RPS24/RPL34/MRPL14/MRPS2/RPL32/RPL37A/RPL41/RPL26L1/MRPS15/MRPS11/RPS13/RPL19/RPL21/RPS23/MRPS10/RPL31/RPL38/RPS6/RPL6/RPL30/RPL39/RPL17/MRPS14/RPL24/MRPL28/RPL12/RPS15A/RPS7/MRPS6/RPSA/MRPL24/RPL23A/RPL7/MRPL19/RPL28/RPS27L/RPS12/MRPL17/RPS21/MRPL18/MRPS18C/MRPL3/RPL22L1/UBA52/MRPS18A/RPL11/MRPL12/RPL7A/MRPL16/RPL37/RPS11/RPS4X/RPLP0/MRPL15/RPS17/RPL10/MRPS16/MRPL20/RPL23/MRPL23/MRPL10/MRPL35/RPS27/MRPS17/RPS28/RPL27A/RPL36/RPS2/RPLP1/RPL10A/MRPL4/RPL36AL/RPL18/MRPL1/FAU/RPL13A/RPS19/RPS29/RPL10L/RPS20/MRPS12/MRPL27/MRPL11/RPL15/MRPL2/RPL14/RPL9/MRPL22/MRPL32/RPL27/RPS18/MRPL9/RPS15/RPL5/RPL36A/RPS25/MRPS7/RPS16/RPL3/MRPL21/RPL13/RPS10/RPS14/MRPL30/MRPS9/RPS5/RPLP2/RPS8/RPL29/RPL22/MRPL13/RPL35/RPL8/RPS3A/RPS9/RPS4Y1/RPS27A/MRPS21/RPL4/RPS3/RPS26/RPL3L/MRPL36	128
KEGG	hsa00240	Pyrimidine metabolism	48/6408	58/8135	0.2867	0.3586	0.1379	NT5C1B/DHODH/ENTPD3/ENTPD4/UPP1/UCK1/NT5C2/NT5C/ASMTL/DUT/TK1/NME1-NME2/NME2/CAD/NT5M/DTYMK/ENTPD1/UPB1/NT5DC4/NME4/DCTPP1/NME3/ENTPD5/ENTPD6/NME6/CDA/CANT1/TYMP/RRM2B/CTPS2/UCKL1/DPYD/RRM1/NUDT2/HDDC2/DCTD/UCK2/UMPS/TK2/ENPP3/NME1/RRM2/UPP2/CMPK2/TYMS/DPYS/NME7/ENPP1	48
KEGG	hsa03250	Viral life cycle - HIV-1	52/6408	63/8135	0.288	0.3586	0.1379	CHMP4A/VPS4A/PDCD6IP/TSG101/BICD1/RAN/VPS4B/MX2/SAMHD1/PPIA/SUPT5H/EP300/CPSF7/CD4/BICD2/CHMP4B/CHMP6/SUPT4H1/CPSF6/RANBP2/APOBEC3F/XPO1/HGS/MAP1S/ELL3/CCNT2/APOBEC3C/SERINC5/CXCR4/TNPO3/MLLT1/FEZ1/APOBEC3G/NUP153/AFF4/ELL2/ELL/PSIP1/SMARCB1/KAT2B/MAP1A/TRIM5/MX1/CCNT1/KAT2A/SERINC3/APOBEC3A/PIN1/APOBEC3D/CREBBP/BST2/MLLT3	52
KEGG	hsa04974	Protein digestion and absorption	84/6408	103/8135	0.2884	0.3586	0.1379	COL6A6/CPB2/COL15A1/COL21A1/CPB1/CELA2A/PRCP/COL8A1/ELN/ATP1B3/KCNE3/COL7A1/KCNQ1/SLC7A8/COL18A1/COL13A1/SLC36A1/COL16A1/SLC38A2/COL6A1/MME/CTRL/SLC1A1/SLC7A7/SLC36A4/COL11A1/SLC3A2/PGA3/PGA4/PGA5/COL9A3/COL11A2/COL9A1/CPA3/COL4A3/FXYD2/SLC8A3/COL27A1/COL4A5/SLC9A3/COL23A1/ATP1A1/CELA2B/COL9A2/COL28A1/SLC8A1/SLC15A1/COL12A1/SLC1A5/COL4A2/KCNN4/XPNPEP2/COL1A1/COL4A6/SLC6A19/COL14A1/KCNJ13/COL22A1/CELA3B/COL6A3/PRSS2/PRSS3/ACE2/COL19A1/COL17A1/CELA3A/CTRB1/CTRB2/COL25A1/COL4A1/CPA2/SLC3A1/COL24A1/MEP1B/ATP1A4/COL5A3/COL6A2/ATP1A3/CPA1/ATP1A2/SLC16A10/KCNK5/COL3A1/PRSS1	84
KEGG	hsa00830	Retinol metabolism	56/6408	68/8135	0.2888	0.3586	0.1379	ALDH1A3/LRAT/UGT2B4/UGT2A3/CYP2A7/ADH1B/ADH7/UGT2B17/PNPLA4/RPE65/AOX1/CYP2S1/ADH5/RETSAT/DGAT1/ADH1A/RDH11/DHRS4/DHRS4L2/CYP2C18/RDH5/DHRS3/RDH12/CYP1A1/CYP2W1/CYP2C9/CYP2B6/DHRS9/CYP3A7/HSD17B6/CYP26A1/UGT1A10/UGT1A7/UGT1A8/CYP2C8/RDH8/RDH13/RDH10/CYP27C1/CYP2A6/CYP3A4/UGT2B15/ALDH1A1/SDR16C5/CYP1A2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/CYP3A5/ADH1C/UGT2A1/UGT2A2/RDH16	56
KEGG	hsa04914	Progesterone-mediated oocyte maturation	83/6408	102/8135	0.3058	0.3782	0.1454	SPDYA/CCNB3/PGR/AKT2/IGF1/PRKACA/ANAPC1/MAPK14/PIK3CB/STK10/ANAPC7/CPEB1/GNAI1/GNAI3/ANAPC2/ARAF/PIK3CD/RPS6KA1/ANAPC10/MAPK1/AKT1/AKT3/RPS6KA3/ADCY8/MAPK9/BRAF/RAF1/MAPK3/CDC27/CDC26/PIK3R1/ADCY6/ANAPC5/MAPK11/CDK1/MAPK13/PIK3R2/KIF22/PIK3CA/ANAPC4/MAPK12/ADCY4/CPEB3/AURKA/GNAI2/SPDYE1/CDC25B/ANAPC13/ADCY7/MAP2K1/RPS6KA2/ANAPC11/PKMYT1/HSP90AA1/FZR1/IGF1R/CCNA2/MAD2L2/CDC16/MAD1L1/CDK2/KRAS/PRKACB/MAPK8/ADCY9/ADCY3/PRKACG/HSP90AB1/INS/BUB1/ANAPC16/MOS/CPEB2/PDE3B/PIK3R3/RPS6KA6/CDC23/CDC25C/MAPK10/CPEB4/ADCY1/CCNB2/ADCY2	83
KEGG	hsa00360	Phenylalanine metabolism	14/6408	16/8135	0.308	0.3782	0.1454	MIF/ALDH3B1/AOC3/IL4I1/AOC2/MAOA/GOT1L1/GOT1/GOT2/PAH/ALDH3A1/ALDH3B2/MAOB/DDC	14
KEGG	hsa00430	Taurine and hypotaurine metabolism	14/6408	16/8135	0.308	0.3782	0.1454	FMO3/GGT7/GGT1/CSAD/ADO/FMO2/GGT5/GADL1/FMO1/GAD2/GGT6/GAD1/BAAT/FMO5	14
KEGG	hsa05414	Dilated cardiomyopathy	78/6408	96/8135	0.3252	0.3979	0.153	ACTC1/ITGA11/IGF1/CACNB3/ACTG1/PRKACA/ITGA5/CACNB1/ITGB4/ATP2A2/ITGA2/CACNA1C/TGFB1/TGFB2/EMD/GNAS/ADCY8/TPM3/ATP2A3/MYBPC3/LAMA1/ITGA2B/CACNG1/ADCY6/LAMA2/TNNT2/ITGB7/DAG1/ACTB/CACNA2D1/PLN/CACNG8/TNF/ADCY4/CACNA2D4/TNNC1/ITGA8/LMNA/ITGB5/ADCY7/TPM4/SGCB/MYH6/ITGA9/ITGAV/CACNA2D2/ITGA7/CACNA1F/ITGA10/PRKACB/ITGA4/TTN/CACNA1S/ITGB3/SLC8A3/ADCY9/SGCG/ADCY3/PRKACG/ITGB1/SLC8A1/MYH7/CACNB2/CACNA1D/CACNG4/CACNG3/TPM1/ITGB8/MYL3/DES/TPM2/ADRB1/ADCY1/RYR2/ITGA3/ADCY2/CACNG5/CACNG2	78
KEGG	hsa00350	Tyrosine metabolism	30/6408	36/8135	0.3321	0.4043	0.1554	ADH1B/ADH7/AOX1/ADH5/ADH1A/MIF/DBH/ALDH3B1/LRTOMT/AOC3/PNMT/FAH/IL4I1/AOC2/COMT/MAOA/GOT1L1/GOT1/GOT2/TYRP1/GSTZ1/ALDH3A1/HGD/TH/DCT/ALDH3B2/MAOB/ADH1C/FAHD1/DDC	30
KEGG	hsa04340	Hedgehog signaling pathway	46/6408	56/8135	0.3338	0.4043	0.1554	CSNK1G2/HHIP/PRKACA/SUFU/GLI2/CUL3/CSNK1E/ARRB1/CSNK1D/MEGF8/CCND1/GLI3/ARRB2/SMURF2/CSNK1A1/IQCE/SCUBE2/MGRN1/SPOP/SMURF1/BTRC/EVC/DISP1/CUL1/SHH/SPOPL/KIF7/HHATL/CSNK1G1/EFCAB7/GPR161/CCND2/FBXW11/PRKACB/PTCH2/PRKACG/BOC/GAS1/PTCH1/CSNK1G3/GLI1/BCL2/KIF3A/HHAT/GSK3B/LRP2	46
KEGG	hsa00270	Cysteine and methionine metabolism	42/6408	51/8135	0.3341	0.4043	0.1554	AGXT2/LDHAL6B/PHGDH/LDHAL6A/TST/SDS/SMS/MPST/DNMT3A/MAT2A/DNMT1/MDH1/MDH2/AHCY/GSS/SRM/AMD1/LDHA/ENOPH1/GCLM/MTR/IL4I1/DNMT3B/ADI1/APIP/GOT1L1/LDHB/BCAT1/GOT1/MRI1/GOT2/BHMT/BCAT2/AHCYL2/MAT2B/CBS/AHCYL1/MTAP/GCLC/LDHC/BHMT2/SDSL	42
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	13/6408	15/8135	0.3532	0.4258	0.1637	FUT9/FUT2/A4GALT/ST3GAL1/HEXB/GBGT1/GLA/HEXA/ST3GAL2/FUT1/NAGA/B3GALT5/B3GALNT1	13
KEGG	hsa04978	Mineral absorption	49/6408	60/8135	0.3573	0.4293	0.165	SLC34A2/TRPV6/ATP7A/FTH1/SLC31A1/SLC11A2/ATP1B3/SLC26A6/HMOX2/MT1H/VDR/ATP2B2/ATP2B1/SLC39A4/MT1F/SLC40A1/ATOX1/S100G/SLC26A3/STEAP2/MT1X/MT1G/MT2A/TF/TRPM7/TRPM6/ATP2B3/ATP2B4/FTL/FXYD2/SLC8A3/SLC9A3/ATP1A1/CLCN2/SLC30A1/MT1E/SLC8A1/SLC6A19/SLC34A1/HEPH/SLC46A1/HMOX1/SLC26A9/ATP1A4/SLC5A1/ATP1A3/STEAP1/ATP1A2/CYBRD1	49
KEGG	hsa00260	Glycine, serine and threonine metabolism	33/6408	40/8135	0.3627	0.4333	0.1666	AGXT2/DAO/PGAM1/GCAT/PHGDH/GLYCTK/GCSH/SDS/PGAM2/DLD/GNMT/GRHPR/AOC3/SARDH/ALAS1/ALDH7A1/AOC2/MAOA/AMT/SHMT2/BHMT/CBS/GAMT/SRR/DMGDH/AGXT/BPGM/PIPOX/SHMT1/MAOB/ALAS2/SDSL/CHDH	33
KEGG	hsa00053	Ascorbate and aldarate metabolism	25/6408	30/8135	0.3632	0.4333	0.1666	UGT2B4/UGT2A3/UGT2B17/GUSB/ALDH9A1/AKR1A1/ALDH2/ALDH1B1/ALDH7A1/ALDH3A2/UGT1A10/UGT1A7/UGT1A8/MIOX/RGN/UGT2B15/KL/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/UGT2A1/UGT2A2	25
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	12/6408	14/8135	0.4029	0.4789	0.1841	B4GALT2/B4GALT1/ST3GAL1/B4GALT3/ST3GAL3/B3GNT7/ST3GAL2/B4GALT4/CHST2/B3GNT2/CHST4/FUT8	12
KEGG	hsa04260	Cardiac muscle contraction	70/6408	87/8135	0.4083	0.4836	0.186	CASQ2/COX6A2/COX8C/COX7B2/COX4I2/ACTC1/UQCRB/UQCRQ/COX5B/CACNB3/CACNB1/COX6B1/COX8A/ATP2A2/CACNA1C/UQCRFS1/UQCR10/TRDN/UQCRH/ATP1B3/COX7B/COX7A2/UQCRC2/TPM3/SLC9A1/SLC9A6/ATP2A3/COX6C/CACNG1/TNNT2/CACNA2D1/COX4I1/CYC1/CACNG8/UQCR11/CACNA2D4/SLC9A7/TNNC1/COX6B2/TPM4/COX5A/MYH6/ASPH/COX6A1/CACNA2D2/COX7C/CACNA1F/CACNA1S/FXYD2/SLC8A3/COX7A2L/ATP1A1/SLC8A1/MYH7/CACNB2/CACNA1D/CACNG4/HRC/CACNG3/MYL4/TPM1/MYL3/TPM2/UQCRC1/RYR2/ATP1A4/CACNG5/ATP1A3/CACNG2/ATP1A2	70
KEGG	hsa00650	Butanoate metabolism	23/6408	28/8135	0.4359	0.5145	0.1978	HADHA/ACSM1/HMGCL/ACADS/HADH/AACS/ECHS1/HMGCS1/OXCT2/ACAT1/HMGCS2/ACSM5/ABAT/OXCT1/ACAT2/ACSM2A/ACSM2B/BDH1/GAD2/GAD1/ACSM3/ALDH5A1/EHHADH	23
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	19/6408	23/8135	0.442	0.5198	0.1999	PCK1/GLS/ATP1B3/MDH1/PCK2/CA4/GLUD1/FXYD2/SLC9A3/ATP1A1/SLC25A10/SLC38A3/CA2/GLUD2/GLS2/ATP1A4/SLC4A4/ATP1A3/ATP1A2	19
KEGG	hsa00380	Tryptophan metabolism	34/6408	42/8135	0.4517	0.5294	0.2035	TPH2/TDO2/HADHA/AOX1/HADH/ALDH9A1/DLD/HAAO/AFMID/ECHS1/DHTKD1/ACMSD/CAT/ALDH2/ALDH1B1/ACAT1/IL4I1/ALDH7A1/GCDH/DLST/CYP1A1/MAOA/ALDH3A2/ACAT2/ASMT/KYNU/CYP1B1/AADAT/KMO/IDO1/MAOB/CYP1A2/EHHADH/DDC	34
KEGG	hsa00062	Fatty acid elongation	22/6408	27/8135	0.4748	0.5525	0.2125	ELOVL2/HADHB/PPT2/HADHA/ACOT1/ACOT2/HADH/MECR/ACAA2/ELOVL1/ELOVL5/ECHS1/HSD17B12/ACOT7/TECR/PPT1/ELOVL3/THEM4/ELOVL4/ELOVL6/ELOVL7/THEM5	22
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	22/6408	27/8135	0.4748	0.5525	0.2125	ELOVL2/ACAA1/FADS2/ACOT1/ACOT2/ELOVL1/ELOVL5/HSD17B12/ACOT7/ACOX1/TECR/HSD17B4/ELOVL3/ACOX3/FADS1/ELOVL4/ELOVL6/ELOVL7/SCD5/SCD/SCP2/BAAT	22
KEGG	hsa03440	Homologous recombination	33/6408	41/8135	0.4836	0.5609	0.2156	BRIP1/MUS81/BRCC3/TOP3A/POLD3/SYCP3/RAD50/SSBP1/XRCC3/TOPBP1/NBN/BRCA1/RAD51C/EME1/POLD2/UIMC1/ATM/RAD52/RPA3/POLD1/RAD54L/RPA1/POLD4/PALB2/BLM/RPA2/RAD54B/RAD51/XRCC2/RBBP8/TOP3B/BARD1/BRCA2	33
KEGG	hsa00982	Drug metabolism - cytochrome P450	57/6408	72/8135	0.5357	0.6191	0.238	UGT2B4/UGT2A3/FMO3/CYP2A7/ADH1B/CYP2C19/ADH7/UGT2B17/AOX1/GSTK1/MGST3/GSTA3/ADH5/CYP2D6/ADH1A/GSTO1/ALDH3B1/GSTT1/MAOA/GSTO2/CYP2C9/CYP2B6/MGST1/GSTP1/FMO2/ALDH3A1/UGT1A10/UGT1A7/UGT1A8/GSTT2/CYP2C8/GSTM3/GSTM4/MGST2/GSTM1/FMO1/ALDH3B2/CYP2A6/CYP3A4/GSTM2/UGT2B15/CYP2E1/MAOB/GSTA1/CYP1A2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/CYP3A5/GSTM5/ADH1C/UGT2A1/UGT2A2/FMO5	57
KEGG	hsa00513	Various types of N-glycan biosynthesis	31/6408	39/8135	0.5493	0.6326	0.2432	MGAT4C/ALG12/MGAT4B/ALG3/B4GALT2/B4GALT1/ALG2/TUSC3/B4GALT3/DAD1/HEXB/MGAT1/CHST9/STT3B/ST3GAL3/MAN1B1/HEXA/RPN2/DDOST/ALG14/MAN2A2/B4GALNT4/ALG9/ALG13/MAN1C1/MAN1A1/MGAT2/STT3A/MAN1A2/ALG1/FUT8	31
KEGG	hsa01232	Nucleotide metabolism	67/6408	85/8135	0.5581	0.6405	0.2463	NT5C1B/ENTPD3/ENTPD4/ENTPD2/UPP1/DGUOK/ADSL/UCK1/NT5C2/ITPA/NT5C/GMPR2/GMPS/NUDT16/ASMTL/AMPD2/DUT/AK2/TK1/NME1-NME2/NME2/NT5M/DTYMK/ENTPD1/AMPD3/IMPDH1/AK1/NT5DC4/NME4/XDH/DCTPP1/NME3/ENTPD5/ENTPD6/HPRT1/AMPD1/APRT/NME6/CDA/CANT1/TYMP/GMPR/RRM2B/PNP/CTPS2/UCKL1/RRM1/AK7/HDDC2/ADK/GUK1/DCTD/UCK2/AK3/GDA/TK2/ENPP3/NME1/ADA/AK5/RRM2/UPP2/CMPK2/IMPDH2/TYMS/NME7/ENPP1	67
KEGG	hsa04520	Adherens junction	56/6408	71/8135	0.5602	0.6408	0.2464	PTPN6/FARP2/PTPN1/ACTG1/IQGAP1/RAC1/RHOA/CTNNA1/VCL/RAC2/ACTN1/WAS/CSNK2B/MAPK1/EP300/WASL/SMAD4/SNAI2/MAPK3/FYN/SMAD3/ACTB/ACTN4/PTPRJ/CDC42/TCF7/CSNK2A2/MAP3K7/CSNK2A1/BAIAP2/ACP1/IGF1R/PARD3/PTPRB/TCF7L2/TGFBR2/PTPRM/SORBS1/SSX2IP/SNAI1/TGFBR1/WASF3/INSR/SRC/CTNNA2/CTNNA3/CTNNB1/YES1/FGFR1/WASF2/CREBBP/CTNND1/PTPRF/MET/WASF1/FER	56
KEGG	hsa00040	Pentose and glucuronate interconversions	27/6408	34/8135	0.5629	0.6416	0.2467	UGT2B4/UGT2A3/UGT2B17/GUSB/SORD/AKR1A1/UGP2/CRYL1/DCXR/XYLB/RPE/DHDH/AKR1B1/UGT1A10/UGT1A7/UGT1A8/UGT2B15/AKR1B10/KL/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/UGT2A1/UGT2A2	27
KEGG	hsa00100	Steroid biosynthesis	16/6408	20/8135	0.5757	0.6528	0.251	CYP24A1/FDFT1/SOAT1/HSD17B7/EBP/LSS/TM7SF2/SOAT2/CYP27B1/LIPA/NSDHL/LBR/DHCR24/CYP2R1/CYP51A1/SQLE	16
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	9/6408	11/8135	0.5766	0.6528	0.251	VKORC1/COQ7/COQ2/NQO1/COQ5/COQ6/VKORC1L1/GGCX/COQ3	9
KEGG	hsa00590	Arachidonic acid metabolism	48/6408	61/8135	0.5799	0.6544	0.2516	CYP2C19/PLA2G2D/GPX5/PTGES2/PTGS1/PLA2G4D/PLA2G4C/GGT1/PTGES3/PLB1/PLA2G6/JMJD7-PLA2G4B/PLA2G4B/LTA4H/CYP2J2/PLA2G12A/ALOX5/ALOX12/CYP4F8/PLA2G4F/ALOX12B/CYP4F2/PLA2G2A/CYP4F3/PTGS2/CBR1/CYP2C9/CYP2B6/GPX7/TBXAS1/GPX2/CYP2C8/ALOX15/GGT5/CBR3/PTGIS/PLA2G4A/CYP2U1/CYP2E1/PTGES/AKR1C3/GPX1/PLA2G2F/PTGDS/EPHX2/PLA2G1B/GPX8/PLA2G12B	48
KEGG	hsa04977	Vitamin digestion and absorption	19/6408	24/8135	0.598	0.6725	0.2586	LRAT/PNLIP/TCN2/LMBRD1/BTD/ABCC1/SLC19A1/PLB1/RBP2/APOA1/SLC23A1/APOB/APOA4/SLC5A6/SCARB1/CUBN/SLC46A1/SLC19A3/SLC19A2	19
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	61/6408	78/8135	0.6126	0.6866	0.264	UGT2B4/UGT2A3/CYP2A7/ADH1B/ADH7/UGT2B17/CYP2F1/GSTK1/CYP2S1/MGST3/GSTA3/ADH5/CYP2D6/ADH1A/GSTO1/AKR7A2/SULT2A1/ALDH3B1/EPHX1/HSD11B1/GSTT1/CYP1A1/GSTO2/CBR1/CYP2C9/DHDH/CYP2B6/CYP1B1/MGST1/GSTP1/AKR7A3/ALDH3A1/UGT1A10/UGT1A7/UGT1A8/GSTT2/GSTM3/GSTM4/MGST2/GSTM1/CBR3/ALDH3B2/CYP2A6/CYP3A4/GSTM2/UGT2B15/CYP2E1/GSTA1/CYP1A2/UGT1A1/UGT1A3/UGT1A4/UGT1A5/UGT1A6/UGT1A9/CYP2A13/CYP3A5/GSTM5/ADH1C/UGT2A1/UGT2A2	61
KEGG	hsa00920	Sulfur metabolism	8/6408	10/8135	0.6405	0.7154	0.2751	TST/MPST/PAPSS2/SUOX/PAPSS1/ETHE1/BPNT1/SELENBP1	8
KEGG	hsa05217	Basal cell carcinoma	49/6408	63/8135	0.6456	0.7188	0.2764	FZD10/WNT2/WNT9B/HHIP/GADD45B/FZD2/WNT3/SUFU/GLI2/WNT7B/DVL1/WNT7A/GLI3/WNT8B/DVL2/APC2/WNT16/CDKN1A/DDB2/WNT10B/BAK1/BAX/FZD1/WNT1/POLK/TCF7/SHH/WNT8A/GADD45A/KIF7/TCF7L2/GADD45G/FZD9/PTCH2/WNT4/TP53/PTCH1/DVL3/WNT5B/CTNNB1/GLI1/APC/AXIN1/FZD6/WNT5A/FZD8/FZD3/FZD7/GSK3B	49
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	28/6408	36/8135	0.6495	0.7207	0.2771	SIRT2/NT5C1B/AOX1/SIRT6/NT5C2/SIRT7/NADK/NT5C/NNMT/NT5M/SIRT3/SIRT4/BST1/NAMPT/NT5DC4/NADSYN1/SIRT5/CD38/PNP/ASPDH/SIRT1/NMNAT1/NMNAT3/ENPP3/QPRT/NMNAT2/NNT/ENPP1	28
KEGG	hsa00565	Ether lipid metabolism	38/6408	49/8135	0.66	0.7299	0.2807	PLA2G2D/PLD4/ENPP6/PAFAH1B3/GDPD1/GDPD3/PLA2G4D/PLA2G4C/PLD3/PLD2/TMEM189/TMEM189-UBE2V1/PAFAH2/PLB1/PLA2G6/PLD1/PAFAH1B2/JMJD7-PLA2G4B/PLA2G4B/LPCAT1/PLA2G12A/CEPT1/PLA2G4F/PLA2G2A/TMEM86B/PLA2G7/CHPT1/ENPP2/PAFAH1B1/AGPS/LPCAT4/LPCAT2/GAL3ST1/UGT8/PLA2G4A/PLA2G2F/PLA2G1B/PLA2G12B	38
KEGG	hsa00564	Glycerophospholipid metabolism	76/6408	98/8135	0.6701	0.7387	0.284	PLA2G2D/PLD4/PGS1/PLA2G4D/DGKD/ETNK2/PCYT2/PCYT1A/LPCAT3/GNPAT/GPCPD1/PISD/LYPLA2/PLA2G4C/PLD3/AGPAT2/PLD2/PEMT/MBOAT7/AGPAT3/PLA2G15/MBOAT2/CDIPT/GPD2/PLB1/PLA2G6/PLD1/CHKB/LCLAT1/JMJD7-PLA2G4B/PLA2G4B/PTDSS2/CDS2/MBOAT1/LPCAT1/DGKQ/DGKZ/PTDSS1/PLA2G12A/PNPLA7/CEPT1/PHOSPHO1/CRLS1/LPGAT1/PLA2G4F/LCAT/LPIN3/GPD1L/DGKA/PLA2G2A/PNPLA6/PCYT1B/CHKA/GPD1/DGKE/LPIN1/CDS1/LPIN2/LYPLA1/CHPT1/AGPAT4/LPCAT4/TAZ/DGKI/DGKG/LPCAT2/AGPAT1/GPAT2/PLA1A/PLA2G4A/ETNK1/PLA2G2F/GPAM/DGKH/PLA2G1B/PLA2G12B	76
KEGG	hsa00220	Arginine biosynthesis	17/6408	22/8135	0.6818	0.7491	0.288	OTC/GPT/ACY1/GLS/GLUL/ASL/NOS3/ARG2/NAGS/GOT1L1/GLUD1/GOT1/GOT2/GPT2/ARG1/GLUD2/GLS2	17
KEGG	hsa00790	Folate biosynthesis	20/6408	26/8135	0.6935	0.757	0.2911	TPH2/ALPP/PCBD1/SPR/DHFR/ALPL/GGH/CBR1/AKR1B1/QDPR/PAH/ALPI/PCBD2/TH/PTS/AKR1B10/AKR1C3/GCH1/MOCS2/GPHN	20
KEGG	hsa04950	Maturity onset diabetes of the young	20/6408	26/8135	0.6935	0.757	0.2911	NKX2-2/RFX6/SLC2A2/NEUROD1/HNF4G/HNF1A/NKX6-1/HNF4A/HES1/GCK/HHEX/PKLR/PDX1/INS/PAX4/ONECUT1/FOXA3/IAPP/MNX1/NEUROG3	20
KEGG	hsa00330	Arginine and proline metabolism	39/6408	51/8135	0.7245	0.7882	0.303	CNDP1/DAO/SAT1/OAT/SMS/ALDH9A1/PRODH/NOS3/SAT2/PYCR2/SRM/P4HA2/ALDH4A1/P4HA1/ALDH18A1/ARG2/AMD1/ALDH2/CKMT2/ALDH1B1/SMOX/ALDH7A1/PYCR1/PRODH2/MAOA/ODC1/GOT1L1/GOT1/CNDP2/ALDH3A2/GOT2/CARNS1/CKM/GAMT/AGMAT/LAP3/ARG1/MAOB/P4HA3	39
KEGG	hsa04742	Taste transduction	66/6408	86/8135	0.7292	0.7908	0.304	GABRA6/GNG13/HTR1D/TAS1R2/TAS2R13/TAS2R50/TAS2R8/TAS2R19/GABRA4/GABRA2/P2RY4/TAS2R16/TAS2R3/GNAT3/TAS2R1/TAS2R41/PLCB2/PRKACA/TAS2R4/PDE1A/TAS2R9/ENTPD2/CACNA1C/P2RX3/ADCY8/ITPR3/PLCB4/TAS2R7/PDE1B/ADCY6/TAS2R40/CHRM3/ADCY4/PLCB3/TAS2R39/TAS2R10/GABBR1/GNB3/SCN2A/SCNN1A/TAS2R45/SCNN1B/PRKACB/GABRA1/GRM4/HTR1F/PRKACG/GABBR2/HTR3C/TAS2R14/SCN9A/HTR3B/GABRA3/HTR1A/PLCB1/HTR1B/HCN4/HTR1E/TAS2R5/GABRA5/TAS1R1/SCNN1G/TRPM5/PDE1C/KCNK5/SCN3A	66
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	59/6408	77/8135	0.7322	0.7914	0.3043	ITGA11/CACNB3/ACTG1/ITGA5/CACNB1/CTNNA1/ITGB4/ATP2A2/ITGA2/CACNA1C/EMD/CDH2/ATP2A3/LAMA1/ITGA2B/CACNG1/LAMA2/ITGB7/DAG1/ACTB/CACNA2D1/CACNG8/CACNA2D4/ITGA8/LMNA/TCF7/ITGB5/SGCB/DSC2/ITGA9/ITGAV/CACNA2D2/ACTN3/TCF7L2/ITGA7/CACNA1F/ITGA10/ITGA4/CACNA1S/ITGB3/SLC8A3/SGCG/ITGB1/SLC8A1/CACNB2/CACNA1D/CACNG4/CACNG3/CTNNA2/CTNNA3/CTNNB1/ITGB8/DES/JUP/RYR2/ITGA3/CACNG5/CACNG2/DSG2	59
KEGG	hsa00591	Linoleic acid metabolism	22/6408	29/8135	0.7382	0.7954	0.3058	CYP2C19/PLA2G2D/PLA2G4D/PLA2G4C/PLB1/PLA2G6/JMJD7-PLA2G4B/PLA2G4B/CYP2J2/PLA2G12A/PLA2G4F/PLA2G2A/CYP2C9/CYP2C8/ALOX15/CYP3A4/PLA2G4A/CYP2E1/PLA2G2F/CYP1A2/PLA2G1B/PLA2G12B	22
KEGG	hsa03040	Spliceosome	113/6408	147/8135	0.7519	0.8075	0.3105	SF3B2/U2AF2/SYF2/SNRPC/DHX8/DDX46/TXNL4A/HNRNPC/USP39/SNRNP200/CCDC12/SNRPB2/RBM22/CTNNBL1/DDX42/U2AF1/LSM4/SF3B4/BUD31/HSPA6/TRA2B/LSM2/DDX23/SNRPB/SNRNP70/BCAS2/PRPF38A/SMNDC1/SF3B5/ZMAT2/RBM8A/EIF4A3/SNW1/SART1/RBM17/PRPF3/PRPF8/XAB2/DHX16/NCBP1/LSM3/LSM6/SLU7/SF3A3/SNRPF/PRPF40A/MAGOH/EFTUD2/HNRNPA3/SF3A1/SNRPD2/SF3B3/PLRG1/CRNKL1/HSPA8/PRPF4/PRPF6/HSPA1L/WBP11/ACIN1/CDC40/HSPA1A/SNRPD3/SNRPA1/HNRNPK/PRPF19/RBM25/MAGOHB/DHX38/DHX15/SNRPE/HNRNPM/PRPF40B/LSM5/SNRPA/PCBP1/CHERP/PUF60/HNRNPA1/HNRNPA1L2/THOC3/RP9/U2AF1L4/TCERG1/CWC15/THOC2/PRPF31/SF3B1/AQR/CDC5L/SNRNP27/HSPA1B/SNRPG/PRPF18/PPIH/DDX5/PPIL1/SF3A2/PHF5A/LSM7/SNRPD1/ISY1/NCBP2/HNRNPU/RBMX/PQBP1/PPIE/THOC1/PRPF38B/SNRNP40/TRA2A/FUS/HSPA2	113
KEGG	hsa03460	Fanconi anemia pathway	41/6408	54/8135	0.757	0.8104	0.3116	BRIP1/UBE2T/MUS81/TOP3A/FANCM/FANCE/POLH/TELO2/PMS2/EME2/FANCA/ERCC1/POLN/MLH1/USP1/ATR/POLK/WDR48/POLI/FANCD2/HES1/BRCA1/RAD51C/FANCG/FANCF/EME1/RPA3/ERCC4/RMI1/REV1/RPA1/PALB2/BLM/FANCL/RPA2/ATRIP/RAD51/TOP3B/BRCA2/REV3L/FANCB	41
KEGG	hsa00512	Mucin type O-glycan biosynthesis	27/6408	36/8135	0.7809	0.8333	0.3204	GALNT10/GALNT7/GALNTL6/ST3GAL1/B3GNT3/GCNT1/C1GALT1C1/GALNT9/ST6GALNAC2/GALNT1/GALNT2/GALNTL5/C1GALT1/ST3GAL2/GALNT4/ST6GALNAC4/GCNT4/GALNT14/GALNT6/GALNT3/B3GNT6/B4GALT5/GALNT12/GALNT13/ST6GALNAC3/GCNT3/GALNT8	27
KEGG	hsa00561	Glycerolipid metabolism	46/6408	61/8135	0.7917	0.8421	0.3238	LIPG/MOGAT3/PNLIP/GLYCTK/DGKD/PNPLA2/ALDH9A1/AGPAT2/AGPAT3/AKR1A1/MBOAT2/GLA/DGAT1/LCLAT1/MBOAT1/DGKQ/DGKZ/ALDH2/ALDH1B1/MGLL/DGAT2/GK2/LPIN3/ALDH7A1/DGKA/DGKE/LPIN1/LPIN2/ALDH3A2/MOGAT2/AGPAT4/AKR1B1/LIPF/GK/DGKI/DGKG/AGPAT1/GPAT2/PNLIPRP3/PNPLA3/AKR1B10/AGK/LPL/PNLIPRP1/GPAM/DGKH	46
KEGG	hsa00600	Sphingolipid metabolism	39/6408	52/8135	0.8016	0.848	0.326	B4GALNT1/SMPD2/GBA2/GALC/PSAP/SPTLC3/ASAH2/GLB1/NEU2/GBA/HEXB/GLA/SMPD1/SMPD4/SPTLC1/DEGS1/HEXA/ARSA/NEU1/SPTLC2/B4GALT6/ACER3/SGMS1/CERK/KDSR/UGCG/ASAH1/SGPL1/SPHK2/GAL3ST1/NEU4/UGT8/DEGS2/SPHK1/SGMS2/SGPP1/SMPD3/NEU3/ENPP7	39
KEGG	hsa00730	Thiamine metabolism	11/6408	15/8135	0.8028	0.848	0.326	ALPP/NFS1/AK2/THTPA/AK1/ACP1/ALPL/TPK1/AK7/ALPI/AK5	11
KEGG	hsa04714	Thermogenesis	178/6408	232/8135	0.8048	0.848	0.326	KLB/GCG/COX6A2/COX8C/COX7B2/COX4I2/NDUFS7/UQCRB/UQCRQ/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/ACTG1/NDUFS2/GRB2/PRKACA/COX17/MAPK14/PRKG2/RPTOR/NPPA/CREB3/COX6B1/TSC1/COX8A/SOS1/NDUFB10/RPS6KB2/SMARCD1/ACSL3/NDUFA4/NDUFV2/SIRT6/UQCRFS1/CPT1C/NDUFB4/NDUFA10/NDUFB2/UQCR10/RPS6KA1/SLC25A29/NDUFAF3/NDUFB11/PNPLA2/SMARCC1/MLST8/MTOR/TSC2/UQCRH/GNAS/AKT1S1/PRKAB1/SLC25A20/COX7B/SDHA/COX7A2/NDUFB6/NDUFB8/RPS6KA3/RPS6/NPR1/ADCY8/UQCRC2/BMP8A/NDUFA7/CPT2/NDUFA2/RHEB/COX6C/PLIN1/NDUFC2/SMARCD3/NDUFA6/ADCY6/MAPK11/CREB5/NDUFS8/NDUFB1/ACTB/MAPK13/NDUFA12/NDUFS3/HRAS/COX15/COX4I1/CYC1/PRKAG1/MAP3K5/CPT1B/UQCR11/MAPK12/NDUFA9/ADCY4/NDUFS4/PRKAG2/SDHB/COX11/NDUFAF1/COX6B2/NDUFA11/ACSL4/SMARCA4/NDUFV1/SMARCD2/PRKAA1/NDUFB5/DPF1/NDUFAB1/CPT1A/NDUFAF2/KDM3A/ADCY7/SDHC/COX19/MGLL/COX5A/NDUFS6/NDUFA3/NDUFB9/RPS6KA2/COX6A1/SOS2/ARID1A/NDUFS5/COX7C/KDM3B/SMARCB1/PRDM16/ATF2/ACSL1/KRAS/NDUFA8/KDM1A/FRS2/CREB3L4/CREB3L2/COX10/PRKACB/NDUFA13/ACSL5/CREB1/ADCY9/UCP1/COX7A2L/NDUFA5/SMARCE1/ADCY3/COX18/PRKACG/NDUFV3/ZNF516/RPS6KB1/SDHD/NDUFAF4/ACSL6/ACTL6A/SMARCA2/FGFR1/MAP2K3/NRAS/COX16/RPS6KA6/UQCRC1/NDUFB7/ADCY1/PRKAG3/BMP8B/PRKAA2/PRKG1/PPARG/ADCY2/CREB3L1/DPF3/NPPB/PRKAB2/NDUFA4L2	178
KEGG	hsa00310	Lysine degradation	47/6408	63/8135	0.8339	0.8759	0.3368	PLOD3/NSD1/HADHA/EZH1/PRDM2/SETDB1/AASS/EHMT2/HADH/SETD2/ALDH9A1/ASH1L/SETD7/DLD/SUV39H1/ECHS1/DHTKD1/TMLHE/EHMT1/SMYD1/SETD1A/ALDH2/SETD1B/ALDH1B1/ACAT1/PLOD1/SMYD3/ALDH7A1/GCDH/DLST/SETDB2/PRDM16/ALDH3A2/ACAT2/DOT1L/PRDM6/PRDM9/EZH2/AADAT/SETMAR/PLOD2/SMYD2/PIPOX/SUV39H2/MECOM/EHHADH/PRDM7	47
KEGG	hsa04390	Hippo signaling pathway	119/6408	157/8135	0.8458	0.8856	0.3405	FZD10/WNT2/DLG2/FGF1/PARD6A/WNT9B/ITGB2/PPP2CA/ACTG1/FZD2/WNT3/PPP2R2C/GLI2/CTNNA1/WNT7B/DVL1/CSNK1E/TP53BP2/CSNK1D/CCND1/WNT7A/WNT8B/DVL2/TGFB1/TGFB2/APC2/SMAD2/PPP2R2D/LLGL1/WNT16/YWHAB/SOX2/SMAD4/BMP8A/SNAI2/MPP5/CCND3/PPP2R2A/WNT10B/SMAD3/BIRC2/ACTB/BBC3/AMH/FZD1/DLG4/YWHAQ/LLGL2/BMP7/SMAD1/YWHAZ/WNT1/AMOT/WWC1/TCF7/YWHAG/BTRC/WTIP/TEAD2/PRKCZ/PPP1CA/YWHAE/BMP6/DLG1/PARD3/WNT8A/PPP2R1A/TCF7L2/PPP2R2B/TGFBR2/NF2/FZD9/CCND2/RASSF1/LATS2/FBXW11/STK3/LIMD1/NKD1/SERPINE1/CRB2/TGFBR1/PARD6G/CRB1/GDF5/WNT4/SCRIB/PPP1CC/PPP2CB/DVL3/BIRC3/WNT5B/CTNNA2/CTNNA3/PPP1CB/CTNNB1/BMPR2/APC/FRMD6/AXIN1/FZD6/BMPR1B/TEAD1/PPP2R1B/TEAD4/WNT5A/FZD8/FZD3/BMPR1A/YAP1/BMP5/PARD6B/BMP8B/TEAD3/FZD7/YWHAH/NKD2/MYC/GSK3B	119
KEGG	hsa00592	alpha-Linolenic acid metabolism	18/6408	25/8135	0.858	0.8934	0.3435	PLA2G2D/ACAA1/FADS2/PLA2G4D/PLA2G4C/ACOX1/PLB1/PLA2G6/JMJD7-PLA2G4B/PLA2G4B/PLA2G12A/PLA2G4F/PLA2G2A/ACOX3/PLA2G4A/PLA2G2F/PLA2G1B/PLA2G12B	18
KEGG	hsa00190	Oxidative phosphorylation	101/6408	134/8135	0.8586	0.8934	0.3435	COX6A2/COX8C/COX7B2/COX4I2/ATP6V1H/NDUFS7/UQCRB/UQCRQ/COX5B/NDUFS1/NDUFC1/NDUFB3/NDUFA1/NDUFS2/COX17/ATP6V0D1/ATP6V0A1/COX6B1/COX8A/NDUFB10/ATP6V0E1/ATP6AP1/NDUFA4/ATP4B/NDUFV2/ATP6V1B2/ATP6V0B/ATP6V1E2/UQCRFS1/NDUFB4/NDUFA10/NDUFB2/UQCR10/NDUFB11/UQCRH/COX7B/SDHA/COX7A2/NDUFB6/NDUFB8/UQCRC2/ATP6V1E1/ATP6V1D/NDUFA7/TCIRG1/NDUFA2/COX6C/NDUFC2/NDUFA6/NDUFS8/NDUFB1/NDUFA12/NDUFS3/COX15/COX4I1/CYC1/UQCR11/LHPP/NDUFA9/NDUFS4/ATP6V1B1/ATP6V1F/SDHB/COX11/COX6B2/NDUFA11/ATP6V1C1/NDUFV1/NDUFB5/NDUFAB1/SDHC/COX5A/NDUFS6/ATP6V0E2/ATP6V0A2/NDUFA3/NDUFB9/COX6A1/ATP6V0C/NDUFS5/COX7C/ATP6V1A/ATP6V0D2/CYCS/NDUFA8/COX10/PPA2/PPA1/NDUFA13/COX7A2L/NDUFA5/ATP6V1G3/NDUFV3/SDHD/ATP6V1G2/UQCRC1/NDUFB7/ATP6V0A4/NDUFA4L2/ATP4A/ATP12A	101
KEGG	hsa04975	Fat digestion and absorption	31/6408	43/8135	0.8934	0.9267	0.3563	MOGAT3/PNLIP/PLA2G2D/SLC27A4/AGPAT2/MTTP/DGAT1/ABCA1/FABP2/NPC1L1/CD36/PLA2G12A/APOA1/ACAT1/DGAT2/SLC27A1/PLA2G2A/APOB/APOA4/ACAT2/GOT2/MOGAT2/SCARB1/LIPF/ABCG5/AGPAT1/ABCG8/PLA2G2F/PNLIPRP1/PLA2G1B/PLA2G12B	31
KEGG	hsa00515	Mannose type O-glycan biosynthesis	16/6408	23/8135	0.9049	0.9357	0.3598	FUT9/B4GALT2/B4GALT1/POMT2/B4GALT3/POMGNT1/ST3GAL3/B3GALNT2/POMT1/CHST10/MGAT5B/B3GAT1/FKTN/FKRP/FUT4/B3GAT2	16
KEGG	hsa05203	Viral carcinogenesis	153/6408	204/8135	0.9202	0.9486	0.3647	HLA-E/USP7/BAD/UBR4/SRF/GTF2H1/GRB2/MDM2/ATF4/PRKACA/RAC1/PIK3CB/ATP6V0D1/RHOA/GTF2E2/HDAC1/STAT5B/SYK/PXN/PSMC1/CREB3/HLA-B/HLA-C/POLB/CCND1/STAT5A/LTBR/HDAC7/ACTN1/IKBKG/PIK3CD/MAPK1/EP300/GTF2A2/TRADD/JAK3/ATF6B/GTF2H2/GTF2H2C/HDAC3/YWHAB/HLA-A/SNW1/MAPK3/CASP3/DDX3X/CCND3/PIK3R1/CASP8/CDKN1A/VDAC3/HDAC5/CREB5/CDK1/TRAF2/BAK1/IRF3/TBPL1/NFKBIA/BAX/HDAC2/HDAC8/ACTN4/HRAS/PIK3R2/SND1/YWHAQ/PIK3CA/IRF9/YWHAZ/DDB1/HDAC11/IL6ST/HLA-G/UBE3A/IRF7/MAPKAPK2/CDC42/GTF2B/LYN/VAC14/HNRNPK/RBPJL/HDAC4/JUN/HLA-F/YWHAG/NFKB2/CDKN1B/CHD4/RELA/RBL2/HDAC6/C3/YWHAE/CDKN2A/DLG1/NFKB1/GTF2E1/CCNA2/TRAF3/DNAJA3/GTF2A1L/HDAC10/SP100/SCIN/CDKN2B/ATP6V0D2/KAT2B/MAD1L1/ATF2/CCND2/GSN/MRPS18B/EIF2AK2/CDK2/KRAS/CREB3L4/TRAF1/CREB3L2/PRKACB/CREB1/RBPJ/GTF2A1/CCNE2/RASA2/PRKACG/SRC/CCNE1/SCRIB/KAT2A/HDAC9/STAT3/CDK4/TP53/PMAIP1/RB1/SKP2/TRAF5/HPN/NRAS/GTF2H3/CDK6/GTF2H4/JAK1/PIK3R3/RBL1/CREBBP/TBP/CCR4/CREB3L1/YWHAH/REL	153
KEGG	hsa04392	Hippo signaling pathway - multiple species	20/6408	29/8135	0.9305	0.9562	0.3677	FAT4/PAK1/CSNK1E/RASSF2/WWC1/WTIP/TEAD2/RASSF4/NF2/RASSF1/LATS2/STK3/LIMD1/DCHS1/FRMD6/TEAD1/DCHS2/TEAD4/YAP1/TEAD3	20
KEGG	hsa00450	Selenocompound metabolism	11/6408	17/8135	0.9497	0.9731	0.3741	TXNRD1/SEPHS2/TXNRD2/MTR/SEPSECS/PAPSS2/SEPHS1/SCLY/MARS2/PAPSS1/PSTK	11
KEGG	hsa00514	Other types of O-glycan biosynthesis	32/6408	47/8135	0.9713	0.9921	0.3815	PLOD3/B4GALT2/GALNT10/POFUT2/B4GALT1/GALNT7/GALNTL6/C1GALT1C1/POMT2/B4GALT3/GXYLT1/GALNT9/GALNT1/GALNT2/GALNTL5/MFNG/ST3GAL3/C1GALT1/POMT1/RFNG/GALNT4/POFUT1/LFNG/GALNT14/GALNT6/GALNT3/ST6GAL2/GXYLT2/GALNT12/GALNT13/ST6GAL1/GALNT8	32
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	67/6408	109/8135	1	1	0.3845	RAN/HEATR1/RPP25/CSNK2B/NXF1/POP4/RRP7A/NVL/GNL3L/EIF6/NXT2/POP7/POP5/NOP10/GAR1/XPO1/NOB1/UTP18/MPHOSPH10/WDR75/GTPBP4/XRN1/RPP30/RPP38/IMP4/SBDS/CSNK2A2/NOL6/NOP56/NHP2/PWP2/CSNK2A1/UTP6/REXO1/NXF2/NXF2B/NXT1/DKC1/NAT10/MDN1/WDR36/IMP3/GNL3/EMG1/TBL3/UTP14A/RPP40/LSG1/UTP15/FBLL1/RIOK1/RBM28/NOP58/REXO2/BMS1/GNL2/NMD3/FCF1/WDR43/TCOF1/RCL1/POP1/UTP14C/RIOK2/FBL/SPATA5/XRN2	67
KEGG	hsa04613	Neutrophil extracellular trap formation	106/6408	190/8135	1	1	0.3845	SLC25A31/ITGB2/AKT2/ACTG1/HMGB1/PLCB2/RAC1/MAPK14/PIK3CB/HAT1/HDAC1/SYK/RAC2/PRKCB/SELPLG/MAP2K2/HDAC7/SLC25A4/NCF4/ITGAM/FCGR2A/VDAC2/GSDMD/NCF1/PIK3CD/NCF2/MAPK1/CASP4/MTOR/AKT1/AKT3/FGB/HDAC3/ITGAL/PPIF/PLCB4/VWF/RAF1/MAPK3/PLCG2/PIK3R1/VDAC3/ITGA2B/HDAC5/MAPK11/AQP9/ACTB/MAPK13/HDAC2/HDAC8/ATG7/FPR1/PIK3R2/AZU1/PIK3CA/MAPK12/CLCN5/CLEC7A/CASP1/SLC25A5/HDAC11/PLCB3/C5AR1/SELP/CR1/HDAC4/TLR8/MAP3K7/RELA/FCGR3B/MAP2K1/CYBA/HDAC6/C3/NFKB1/CYBB/SIGLEC9/CAMP/FCGR1A/HDAC10/CLCN3/TLR2/C5/GP1BA/TLR7/PLCG1/ITGB3/AGER/SRC/MPO/PRKCG/HDAC9/CR1L/PADI4/CLCN4/PLCB1/FCGR3A/PRKCA/PIK3R3/TLR4/SLC25A6/VDAC1/FGA/CTSG/FPR3/ELANE	106
KEGG	hsa05034	Alcoholism	103/6408	187/8135	1	1	0.3845	GNG13/ADORA2A/GNG5/GRB2/ATF4/PRKACA/SHC1/GNB1/HAT1/HDAC1/GNG2/CREB3/GNG10/SOS1/CALML6/CRH/HDAC7/GNAI1/GNAI3/ARAF/MAPK1/ADORA2B/GRIN2B/SHC3/SLC29A3/GNAS/ATF6B/HDAC3/GNGT2/BRAF/RAF1/MAPK3/GNB2/CALM2/HDAC5/CREB5/HDAC2/HDAC8/GNB5/HRAS/SLC29A2/CAMKK2/HDAC11/CALM1/CAMKK1/GNAI2/HDAC4/GNB3/DRD1/GNG3/MAP2K1/HDAC6/PPP1CA/GNAO1/GNG7/GNG11/SOS2/HDAC10/GRIN2C/CALML4/MAOA/ATF2/CALML5/KRAS/GRIN1/CREB3L4/CREB3L2/GNG8/PRKACB/CREB1/GNB4/GNGT1/GNG12/CALM3/GRIN2D/PRKACG/CALML3/PPP1CC/HDAC9/DRD2/SLC29A1/SLC18A2/PPP1CB/BDNF/TH/SHC2/GRIN3B/NTRK2/NRAS/SHC4/FOSB/GRIN2A/SLC18A1/PKIA/MAOB/GRIN3A/GNG4/SLC6A3/CAMK4/CREB3L1/PDYN/PPP1R1B/DDC	103
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	23/6408	66/8135	1	1	0.3845	HARS2/PARS2/FARS2/FARSB/YARS2/TARS2/CARS2/GATC/RARS2/VARS2/FARSA/SEPSECS/MTFMT/IARS2/SARS2/EARS2/MARS2/PSTK/LARS2/QRSL1/WARS2/NARS2/AARS2	23
KEGG	hsa04740	Olfactory transduction	117/6408	440/8135	1	1	0.3845	OR2B2/CNGA3/GNG13/OR10A5/OR11A1/OR12D2/OR14J1/OR1A2/OR2A7/OR2J3/OR4D2/OR51B4/OR51E1/OR5I1/OR5V1/OR6B1/OR3A1/OR52A1/OR51I2/OR1G1/OR1D2/OR10H3/OR6A2/OR1A1/OR7E24/OR8D2/OR5P2/OR2B3/OR12D3/CAMK2G/PRKACA/PRKG2/GNB1/OR2W1/PDE1A/OR2C3/ARRB1/CALML6/OR5J2/OR5L2/OR8B8/ARRB2/OR51B6/RGS2/OR13C4/GUCY2D/CALM2/PDE1B/OR7A5/OR51B5/OR1J2/OR1Q1/CNGB1/CALM1/OR51B2/OR1E1/OR1E2/OR7A17/OR3A2/CAMK2B/OR4D1/GNG7/OR1J4/CALML4/CALML5/OR8D1/PDE2A/OR2S2/OR2H2/PRKACB/OR2L13/OR10C1/CNGA4/OR10A4/SLC8A3/OR2J2/NCALD/OR5H14/OR5H15/ADCY3/OR10J1/OR8G1/CALM3/PRKACG/SLC8A1/CALML3/OR1C1/CAMK2D/OR2W3/OR10H2/CAMK2A/OR2C1/OR7A10/OR52D1/OR2F1/OR1D4/OR1D5/OR7C2/OR4F16/OR4F21/OR4F29/OR4F3/OR1F1/OR2H1/OR51M1/OR51E2/OR51I1/OR5H1/OR2A5/OR10A3/OR2A4/OR5P3/OR2F2/OR2M4/PRKG1/PDE1C/GNAL	117
KEGG	hsa05206	MicroRNAs in cancer	154/6408	310/8135	1	1	0.3845	CYP24A1/TNN/SERPINB5/ZFPM2/EFNA3/BCL2L11/GRB2/E2F1/MDM2/UBE2I/BMF/PIK3CB/ITGA5/SHC1/RHOA/WNT3/HDAC1/RPTOR/PRKCB/SOS1/CCND1/MAP2K2/TGFB2/PIK3CD/MIR101-1/APC2/GLS/MAPK1/DNMT3A/NOTCH1/MCL1/EZR/MTOR/EP300/PDGFRB/DNMT1/PTEN/CRKL/ABCC1/EFNA4/RAF1/MAPK3/ROCK1/CASP3/IRS2/PLCG2/PIK3R1/CDKN1A/HDAC5/THBS1/BAK1/HDAC2/TNXB/HRAS/PIK3R2/TP63/IKBKB/PIK3CA/CCNG1/MAPK7/CDC25B/HNRNPK/STMN1/HDAC4/CDKN1B/IRS1/MIR21/BRCA1/BCL2L2/MAP2K1/CDCA5/MIRLET7D/VEGFA/SLC7A1/ST14/CDKN2A/ATM/NFKB1/SOS2/MDM4/ABL1/BMI1/PDCD4/E2F3/CRK/DNMT3B/SOX4/VIM/MMP9/CCND2/RASSF1/PAK4/KRAS/PTGS2/PLAU/PLCG1/ITGB3/MIR214/SIRT1/DICER1/CD44/IGF2BP1/PDGFB/CCNE2/SOCS1/FSCN1/CYP1B1/CCNE1/RECK/PRKCG/RPS6KA5/STAT3/EZH2/TP53/ZEB1/EFNA5/TIMP3/ERBB3/SLC45A3/PDGFA/BMPR2/MIR30C2/FOXP1/APC/EFNA2/TPM1/MMP16/PRKCA/NRAS/ZEB2/BCL2/CDK6/NOTCH2/SHC4/MARCKS/GLS2/PIK3R3/E2F2/CREBBP/RDX/CDC25C/EFNA1/DDIT4/MIR10B/FZD3/HMOX1/MET/PIM1/HOXD10/PDGFRA/MYC/HMGA2/ABCB1/PRKCE	154
KEGG	hsa05322	Systemic lupus erythematosus	49/6408	136/8135	1	1	0.3845	C9/CD40/C1R/ACTN1/FCGR2A/SNRPB/GRIN2B/C6/IL10/C2/ACTN4/TRIM21/TNF/SNRPD3/HLA-DMB/C1QB/FCGR3B/C3/FCGR1A/C5/C1QA/CD86/HLA-DMA/SSB/CD40LG/HLA-DRA/SNRPD1/HLA-DPA1/CD80/C1S/HLA-DOA/HLA-DQB1/C8A/FCGR3A/CD28/C4A/C4B/C1QC/IFNG/GRIN2A/HLA-DOB/HLA-DQA1/HLA-DQA2/HLA-DRB3/HLA-DRB5/HLA-DRB1/HLA-DRB4/CTSG/ELANE	49