ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05417	Lipid and atherosclerosis	213/6806	215/8135	1.233e-14	4.118e-12	1.505e-12	IFNA2/IFNB1/MMP3/CYP2A7/IFNA1/IFNA13/IL12A/NOX1/CD40/HSPA5/BAD/CASP9/ATF4/CAMK2G/VAV1/RAC1/CALML6/HSP90B1/PPP3R2/RHOA/PLCB2/MAPK14/TICAM1/NCF4/IL1B/BAX/CASP3/ARHGEF1/MAPK1/PIK3CB/HSPA4/CD14/IRAK1/NCF1/TANK/XBP1/IKBKG/NFE2L2/MYD88/PIK3CD/RXRB/AKT3/TBK1/NFATC1/HRAS/NCF2/TRAF3/TNFRSF1A/CALM1/EIF2S1/NFKBIA/IRAK4/PYCARD/MAP3K7/BID/IRF3/POU2F2/HSPA1L/MAPK3/PIK3CA/NFKB1/MAPK12/HSPA6/APOA1/TRAF6/MAP2K4/FAS/CASP6/CALML4/PIK3R2/ROCK2/DDIT3/RXRA/CDC42/CYP1A1/FOS/TNF/MAPK13/MAPK9/IKBKB/APAF1/HSPA8/HSP90AB1/HSPA1B/NOS3/TRAF2/CYBA/IFNA8/TAB2/AKT2/AGER/PIK3R1/RAP1B/CASP8/HSPD1/CALML5/RAP1A/MAP3K5/LYN/MAP2K6/CD36/CYBB/NLRP3/PPP3CA/LDLR/GSK3B/TAB1/CXCL1/NFATC2/SOD2/JUN/JAK2/PLCB4/AKT1/ABCA1/VAV2/SELE/NRAS/CCL5/ATF6/ITPR1/POU2F1/ICAM1/EIF2AK3/SELP/CAMK2A/HSPA1A/CALML3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CYP2J2/PPP3CB/IFNA16/TIRAP/MAPK11/IL12B/CHUK/CAMK2B/CXCL3/CYP2C9/TNFRSF10B/IKBKE/CYP2C8/MMP9/PPP3CC/TLR2/KRAS/PLCB3/CYCS/FASLG/PTK2/CASP1/PDPK1/TLR6/CAMK2D/LY96/APOA4/MAP2K7/TP53/MAPK8/CYP2A6/MIB2/HSP90AA1/CALM2/APOB/PLCB1/BCL2L1/RELA/TNFSF10/IL18/MIB1/PRKCA/PLCG1/IFNA17/STAT3/CALM3/PPP3R1/TLR4/CASP7/CD40LG/SRC/MAPK10/NFATC3/PIK3R3/MMP1/VCAM1/ABCG1/CYP2B6/IRF7/BCL2/RXRG/TNFRSF10A/CCL2/MAP2K3/IL6/TICAM2/HSPA2/POU2F3/CCL3/CCL3L1/CCL3L3/VAV3/VLDLR/LBP/PPARG/CXCL2/OLR1/ERN1	213
KEGG	hsa05165	Human papillomavirus infection	319/6806	331/8135	1.12e-13	1.871e-11	6.84e-12	TNN/IFNA2/IFNB1/COL6A6/IFNA1/IFNA13/WNT2/DLG2/FZD10/WNT9B/IRF1/ATP6V1H/HLA-E/ATP6V0D1/WNT3/ITGA11/FZD2/LAMB1/CREB3/BAD/UBR4/PPP2CA/PPP2R5D/GRB2/PPP2R5C/CCND1/SLC9A3R1/ITGA5/PPP2R2D/VTN/THBS4/ITGA2/MAP2K2/VWF/HDAC2/NFX1/PARD6A/TICAM1/ITGB4/PPP2R2C/BAX/CASP3/WNT7A/MDM2/ATP6V1E2/TSC2/TSC1/BCAP31/TYK2/PSMC1/MAPK1/HDAC1/PIK3CB/WNT8B/NOTCH1/BAK1/ATP6V0A1/APC2/WNT16/ATP6AP1/TADA3/PDGFRB/RHEB/WNT7B/IKBKG/PPP2R2A/PIK3CD/PRKACA/AKT3/ATP6V1F/PTGS2/TBK1/LAMA2/DVL2/HRAS/ATP6V1E1/FADD/RAF1/TRAF3/TNFRSF1A/RPS6KB2/FZD1/IFNAR1/E2F1/EP300/EIF4EBP1/HLA-C/MAML1/PPP2R1A/ITGA4/WNT1/ATP6V1G1/TCIRG1/IRF3/HES4/MTOR/MAPK3/PXN/PIK3CA/MFNG/NFKB1/HLA-B/WNT8A/ATP6V0B/PTEN/ATP6V1B2/JAK1/TBPL1/HLA-A/FAS/CDK2/TERT/ITGA2B/PIK3R2/COL6A1/RFNG/CDC42/PPP2R5B/TNF/ATP6V1B1/COL9A3/ATP6V0A2/IKBKB/LAMA3/UBE3A/FZD9/ITGA9/LLGL2/TRADD/LLGL1/THBS3/ATP6V1A/ATP6V0E2/ATM/IFNA8/PARD3/AKT2/CCND3/FOXO1/PIK3R1/CASP8/CDKN1B/TUBG2/ATP6V0D2/COL9A1/SOS1/ATP6V1D/ATP6V0C/ATP6V1C1/CHD4/PTGER4/GNAS/GSK3B/PRKCZ/PSEN1/AKT1/TCF7/ATP6V0E1/TNXB/ATP6V1G3/SOS2/NRAS/LAMA1/ITGA7/COL4A3/HES1/THBS1/MPP5/WNT10B/PPP2R3C/LAMC3/CCND2/PPP2R5A/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/MAML3/CSNK1A1/COL4A2/IFNA16/HLA-F/RBPJ/ITGA10/IRF9/ITGB7/PPP2R5E/HES6/DVL3/CHUK/VEGFA/CREB3L4/ITGB1/TBP/IKBKE/JAG1/PPP2R3A/COL6A3/MAGI1/PPP2R2B/KRAS/CREB3L2/RPS6KB1/WNT4/ATR/PRKACB/PPP2R3B/RB1/COL4A5/PRKACG/COMP/DVL1/FASLG/COL4A6/PTK2/SPP1/HES2/CREB5/PRKCI/PPP2CB/CDK6/CTNNB1/LAMC1/TP53/CHAD/CREB3L1/LFNG/EGF/CCNA2/PARD6G/HEYL/COL9A2/HES5/RBL2/CDKN1A/ITGAV/RELA/COL1A1/ITGB3/LAMA5/DLG3/ITGA8/DLG1/AXIN1/LAMB4/CREB1/IFNA17/LAMB2/THBS2/ITGB8/NOTCH2/SCRIB/MAML2/CCNE1/CCNE2/ATP6V1G2/WNT5B/FZD5/LAMC2/TUBG1/STAT2/RBPJL/PIK3R3/TCF7L2/FN1/WNT5A/FZD6/COL4A1/STAT1/ITGB5/APC/ATP6V0A4/MX2/CREBBP/FZD7/FZD8/PARD6B/LAMB3/COL2A1/MAP2K1/HES7/NOTCH3/EIF2AK2/AXIN2/RBL1/CRB3/FZD4/HEY1/NOTCH4/TNC/TCF7L1/COL4A4/TNR/ISG15/MX1/ITGA3/CREB3L3/WNT11/HEY2/CCNA1/EGFR/ITGA6/WNT2B/IFNAR2/OASL/WNT9A/LAMA4/WNT10A/FZD3/COL6A2/WNT6/ATP6V1C2/COL1A2/RELN	319
KEGG	hsa04151	PI3K-Akt signaling pathway	338/6806	354/8135	2.011e-12	2.239e-10	8.186e-11	TNN/IL2/IFNA2/GYS2/GNG13/IFNB1/COL6A6/IFNA1/IFNA13/FGF5/CHRM2/GHR/EFNA3/IGF1/ITGA11/LAMB1/CREB3/FGF3/BAD/CASP9/ATF4/BCL2L11/PPP2CA/PPP2R5D/GRB2/GNB1/PPP2R5C/CCND1/MLST8/GNG2/ITGA5/CDC37/IL2RG/PPP2R2D/RAC1/RPTOR/VTN/HSP90B1/THBS4/ITGA2/MAP2K2/VWF/PKN3/EIF4E2/GNG5/GNB2/ITGB4/PPP2R2C/PIK3R5/EFNA4/MDM2/TSC2/TSC1/F2R/MAPK1/PIK3CB/ANGPT2/SYK/EPOR/JAK3/PDGFRB/RHEB/VEGFC/IKBKG/PPP2R2A/KIT/ATF6B/PIK3CD/AKT3/IL4R/IL6R/FGF18/LAMA2/HRAS/LPAR4/RAF1/CSF3R/RPS6KB2/IFNAR1/EIF4EBP1/CSF1R/PPP2R1A/PCK1/ITGA4/IL2RA/GNGT2/MTCP1/STK11/MTOR/CRTC2/MAPK3/PIK3CA/NFKB1/FGF23/PTEN/FLT4/FGF7/G6PC/JAK1/CDK2/ITGA2B/GNG3/PIK3R2/COL6A1/RXRA/PPP2R5B/COL9A3/IKBKB/LAMA3/FGF1/LPAR2/HSP90AB1/PDGFD/FGF6/GNG8/GNG7/ITGA9/GNG10/PKN2/NOS3/YWHAQ/THBS3/SGK3/IL4/IGF1R/GYS1/IFNA8/AKT2/CCND3/YWHAE/PIK3R1/G6PC3/LPAR1/YWHAZ/CDKN1B/NTF3/BRCA1/NTRK1/PIK3AP1/COL9A1/SOS1/PDGFC/YWHAH/VEGFB/GSK3B/YWHAG/JAK2/GNB3/FGFR4/AKT1/TNXB/LPAR6/SOS2/NRAS/LAMA1/ITGA7/HGF/FGF16/PHLPP2/MYC/COL4A3/THBS1/PRKAA1/PHLPP1/FGFR2/GNG11/PPP2R3C/PDGFB/CD19/YWHAB/LAMC3/CCND2/GNG12/G6PC2/PPP2R5A/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/FLT3LG/CDK4/COL4A2/IFNA16/ITGA10/NR4A1/GNB5/PIK3CG/ITGB7/PPP2R5E/RPS6/CHUK/VEGFA/CREB3L4/IRS1/ITGB1/PCK2/PKN1/IL3/FGF17/ERBB2/IL3RA/SGK1/PPP2R3A/PRLR/BDNF/COL6A3/MAGI1/TLR2/PPP2R2B/TGFA/KRAS/CREB3L2/OSM/THEM4/RPS6KB1/PPP2R3B/COL4A5/COMP/IL2RB/FASLG/IL7R/COL4A6/PTK2/SPP1/EIF4B/MCL1/PDPK1/CREB5/INS/PIK3R6/FGF10/PPP2CB/CDK6/LAMC1/CHRM1/TP53/LPAR5/CHAD/PGF/CREB3L1/INSR/EGF/HSP90AA1/COL9A2/RBL2/BCL2L1/GNGT1/FLT1/CDKN1A/FGF19/CSF3/ITGAV/RELA/COL1A1/SGK2/ITGB3/LAMA5/ANGPT4/ITGA8/EFNA5/EIF4E/ATF2/DDIT4/LAMB4/PRKCA/CREB1/NTF4/FGF4/ERBB4/IFNA17/EFNA1/LAMB2/THBS2/KDR/FOXO3/ITGB8/TLR4/NTRK2/FGF2/FGF22/FLT3/FGF20/CCNE1/CCNE2/LAMC2/FGF9/EFNA2/PIK3R3/OSMR/FN1/GNB4/PDGFA/BCL2/COL4A1/FGFR1/GH1/GH2/ITGB5/IL6/GNG4/EREG/IGF2/TCL1A/LAMB3/IL7/LPAR3/COL2A1/MAP2K1/ERBB3/PRKAA2/CSH1/CSF1/TNC/PDGFRA/MAGI2/PRL/FGF8/COL4A4/TNR/TCL1B/NGFR/ITGA3/CREB3L3/FGFR3/CSH2/EPO/EGFR/ITGA6/IFNAR2/MET/MYB/LAMA4/COL6A2/COL1A2/RELN	338
KEGG	hsa05132	Salmonella infection	240/6806	249/8135	1.438e-10	1.2e-08	4.389e-09	PIK3C3/TUBA1C/ARPC1A/ARL8A/CYTH1/RAC1/CYFIP2/GAPDH/ACTR10/HSP90B1/ACTG1/DYNLL1/MAP2K2/VPS41/ARF1/TUBA1B/NLRC4/RHOA/MAPK14/IL1B/NCKAP1L/PAK1/BAX/CASP3/RAB5B/ARPC4/VPS18/TUBA1A/VPS39/PLEKHM1/FYCO1/MLKL/ACTR2/ARPC1B/MAPK1/PIK3CB/PLEKHM2/ELMO1/BAK1/DYNLL2/CD14/DYNLRB1/PFN1/IRAK1/DCTN6/TXN/DCTN3/PIK3C2G/ELMO2/DYNC1H1/KLC1/GSDMD/TUBA4A/DYNLT3/FHOD1/IKBKG/MYD88/MYLPF/WASL/PIK3CD/CSE1L/ARPC2/AKT3/CYTH4/RRAS/DYNC1LI1/ARL8B/HRAS/S100A10/RIPK2/EXOC7/RIPK3/FADD/RAF1/TNFRSF1A/PODXL/ACTR1A/NFKBIA/VPS33A/RIPK1/ARPC5/IRAK4/PYCARD/RAB9A/MAP3K7/DCTN1/ARPC3/MAPK3/PIK3CA/CASP4/NFKB1/MAPK12/STX10/ANXA2/TUBA3D/TUBA3E/TUBAL3/RHOG/ACTR3B/TRAF6/TUBB1/ARPC5L/TLR9/MAP2K4/ACTB/ACTR1B/FLNC/KLC4/ROCK2/WASF3/CDC42/FOS/TNF/MAPK13/MAPK9/IKBKB/VPS11/TLR5/M6PR/HSP90AB1/NOD1/PFN4/DCTN5/CYTH3/DNM2/TRADD/RHOB/SNX33/VPS16/TRAF2/DYNC1LI2/TAB2/AKT2/TUBB/CASP8/MYL12A/MYL12B/FLNA/TUBA3C/EXOC4/MAP2K6/KIF5B/KIF5C/NLRP3/NAIP/TAB1/JUN/DCTN4/TUBA8/AKT1/TCF7/DCTN2/RHOH/RPS3/MYC/DYNLT1/MYO6/ACTR3/MYL10/DYNC2LI1/PTPRC/TXN2/RAB5A/TIRAP/PIK3CG/MAPK11/KPNA1/CYFIP1/ARF6/BIRC2/CHUK/GCC2/PKN1/TNFRSF10B/MYL9/TAB3/TUBB6/TLR2/RAB5C/CYCS/SNX9/ACBD3/CASP1/TLR6/LY96/PFN2/SKP1/CTNNB1/TUBB3/MAP2K7/MAPK8/EXOC2/HSP90AA1/AHNAK/KPNA4/FLNB/PIK3C2A/RELA/RALA/KLC3/DYNC1I2/CASP5/TNFSF10/IL18/RILP/AHNAK2/TLR4/CASP7/RAB7B/MYL7/KPNA3/MAPK10/LEF1/PAK3/SNX18/MYL5/TCF7L2/FBXO22/MYL2/NCKAP1/BCL2/EXOC5/TNFRSF10A/KIF5A/RAB9B/MAP2K3/CYTH2/RAB7A/DYNC1I1/IL6/BIRC3/ABI1/MAP2K1/KLC2/DYNLRB2/TCF7L1/ACTR3C/DYNC2H1/TUBB2B/RHOJ	240
KEGG	hsa04010	MAPK signaling pathway	280/6806	294/8135	4.616e-10	2.566e-08	9.381e-09	PTPRR/FGF5/EFNA3/IGF1/CACNB3/FGF3/CACNB1/ATF4/GRB2/ARRB1/TGFB1/RAC1/MAP2K5/PPP3R2/SRF/MAP2K2/TGFB2/MAP3K3/CRKL/MAPK14/CACNA1C/PLA2G4D/IL1B/PAK1/CASP3/EFNA4/PRKCB/CACNG1/DUSP2/PAK2/GADD45B/DAXX/ARRB2/MAPK1/ARAF/RASGRP2/ANGPT2/CD14/IRAK1/TAOK3/CACNA1S/CACNA2D1/MAPK7/PDGFRB/VEGFC/IKBKG/NF1/RPS6KA1/MYD88/KIT/PRKACA/AKT3/RRAS/FGF18/NFATC1/HRAS/DUSP1/RAF1/TNFRSF1A/RELB/PTPN7/MAPKAPK5/RPS6KA3/RAC2/CSF1R/TAOK2/CACNG8/MAP4K2/IRAK4/MAP3K7/HSPA1L/MAPKAPK3/PPM1B/PLA2G4C/STMN1/MAPK3/MAP3K12/STK4/NFKB1/FGF23/MAPK12/JMJD7-PLA2G4B/PLA2G4B/HSPA6/CACNA2D4/TRAF6/FLT4/MAP2K4/FGF7/FAS/FLNC/RPS6KA4/DDIT3/NFKB2/CDC42/FOS/TNF/MAPK13/MAPK9/IKBKB/FGF1/MAPKAPK2/MAX/HSPA8/HSPB1/PDGFD/FGF6/MAP4K1/HSPA1B/TRADD/ELK1/TRAF2/IGF1R/RASA2/CACNA2D2/TAB2/AKT2/TGFBR2/RAP1B/PLA2G4F/MAP4K4/CACNA1F/NTF3/RAP1A/FLNA/MAP3K5/MAP2K6/NTRK1/DUSP3/SOS1/PDGFC/CACNA1H/PPP3CA/VEGFB/CDC25B/TAB1/JUN/MAP3K11/FGFR4/AKT1/MAPK8IP1/DUSP9/ECSIT/SOS2/NRAS/HGF/FGF16/PTPN5/MYC/FGFR2/PDGFB/MAPK8IP3/HSPA1A/CRK/GNG12/FLT3LG/RASGRP1/PPP3CB/NR4A1/MAP3K4/MAPK11/DUSP7/CACNA2D3/CHUK/VEGFA/CACNB2/FGF17/ERBB2/IL1R1/BDNF/IL1RAP/PPP5C/MAP3K6/PPP3CC/TAOK1/TGFA/MAP3K14/KRAS/PRKACB/PRKACG/DUSP10/FASLG/MAP3K2/MAP3K8/RASA1/BRAF/INS/CACNG3/FGF10/CACNA1D/MKNK1/MAP2K7/TP53/MAPK8/PGF/INSR/GADD45A/EGF/FLNB/PLA2G4A/PRKCG/FLT1/FGF19/DUSP16/RELA/ANGPT4/RASGRP4/PPM1A/EFNA5/MEF2C/GNA12/ATF2/PRKCA/NTF4/FGF4/ERBB4/CACNG4/EFNA1/MKNK2/ELK4/RPS6KA2/RAPGEF2/KDR/PPP3R1/DUSP8/NTRK2/FGF2/FGF22/FLT3/TGFBR1/RASGRF2/FGF20/RPS6KA6/CACNA1G/MAPK10/FGF9/NFATC3/EFNA2/GADD45G/STK3/DUSP6/CACNA1E/PDGFA/CACNG5/CACNA1I/RRAS2/RASGRF1/RPS6KA5/MAP2K3/CACNA1B/FGFR1/JUND/EREG/IGF2/HSPA2/MAP3K1/CACNG2/CACNA1A/MAPT/MAP2K1/ERBB3/MECOM/DUSP4/CSF1/MAPK8IP2/PDGFRA/MAP4K3/TGFB3/FGF8/DUSP5/RAC3/NGFR/MRAS/FGFR3/CACNG6/NLK/EGFR/MET/RASGRP3/IL1A	280
KEGG	hsa04935	Growth hormone synthesis, secretion and action	119/6806	119/8135	5.1e-10	2.566e-08	9.381e-09	GHR/IGF1/GHRH/CREB3/GNAQ/ATF4/GRB2/JUNB/MAP2K2/CRKL/PLCB2/MAPK14/ADCY8/CACNA1C/GNAI1/PRKCB/MAPK1/PIK3CB/STAT5B/CACNA1S/GHRL/BCAR1/SSTR5/ATF6B/PIK3CD/PRKACA/AKT3/SHC1/HRAS/STAT5A/RAF1/ITPR3/EP300/SHC3/GNA11/MTOR/PLCG2/MAPK3/PIK3CA/MAPK12/MAP2K4/PIK3R2/FOS/MAPK13/MAPK9/IRS2/SSTR3/AKT2/PIK3R1/CACNA1F/GNAI2/ADCY6/MAP2K6/SOS1/GNAI3/GNAS/GSK3B/JAK2/PLCB4/AKT1/SOS2/NRAS/ITPR1/CRK/SST/MAPK11/ITPR2/ADCY9/IRS4/ADCY4/CREB3L4/IRS1/SSTR1/KRAS/CREB3L2/PLCB3/PRKACB/PRKACG/PTK2/POU1F1/CREB5/CACNA1D/MAPK8/CREB3L1/SOCS3/PLCB1/PRKCG/ADCY7/IGFALS/ATF2/PRKCA/CREB1/PLCG1/STAT3/SHC4/MAPK10/PIK3R3/STAT1/GHSR/SOCS1/MAP2K3/GH1/GH2/MAP3K1/CREBBP/ADCY5/GHRHR/MAP2K1/ADCY10/CSH1/ADCY3/ADCY1/CREB3L3/CSH2/SHC2/ADCY2/IGFBP3/SOCS2/SSTR2	119
KEGG	hsa04020	Calcium signaling pathway	231/6806	240/8135	5.378e-10	2.566e-08	9.381e-09	CASQ2/FGF5/DRD5/LHCGR/GRPR/CHRM2/HTR2C/SLC25A31/RYR3/PLCD1/TNNC2/ADORA2A/ADRA1D/PTAFR/PDE1A/ITPKC/GNAQ/FGF3/CAMK2G/GNA15/HRH2/STIM1/CALML6/ADRA1A/PPP3R2/TRDN/PLCB2/SLC25A4/ADCY8/CACNA1C/OXTR/TACR3/VDAC2/PRKCB/ADORA2B/F2R/HRH1/PTK2B/CASQ1/MYLK2/HTR6/SLC25A5/CHRM3/CACNA1S/PHKG2/PHKB/PDGFRB/TNNC1/VEGFC/PRKACA/HTR2A/ATP2B3/PHKA2/FGF18/ATP2A2/CALM1/ITPKB/ITPR3/GNA11/HTR2B/CCKBR/PLCG2/FGF23/ATP2A3/CAMK1D/FLT4/PHKG1/FGF7/P2RX7/ATP2B2/CALML4/P2RX4/RET/FGF1/PDGFD/FGF6/ORAI1/ATP2B1/TPCN1/NOS3/ATP2B4/P2RX6/PPIF/LTB4R2/NTRK3/HTR7/CACNA1F/CALML5/PDE1B/NTRK1/PDGFC/CACNA1H/PLCD4/P2RX3/PPP3CA/PTGFR/VEGFB/GNAS/PLCB4/MST1/FGFR4/CHRNA7/SLC8A1/HTR5A/HGF/FGF16/AGTR1/ITPR1/P2RX1/FGFR2/PLCZ1/PDGFB/CAMK2A/VDAC3/GRIN2D/MST1R/CALML3/TACR2/PLCD3/PPP3CB/ITPR2/ORAI3/ADCY9/ADCY4/VEGFA/MCOLN1/DRD1/SLC25A6/SLC8A3/FGF17/CAMK2B/ERBB2/PPP3CC/MYLK3/PLCB3/TPCN2/TBXA2R/CXCR4/PRKACB/PRKACG/PTGER3/GRIN2C/ADRB2/ORAI2/CAMK1/RYR1/CAMK2D/FGF10/CACNA1D/SPHK2/CHRM5/HRC/CHRM1/PLN/EGF/CALM2/MYLK/PLCB1/STIM2/PRKCG/FLT1/FGF19/ADCY7/AVPR1A/TACR1/ASPH/PRKCA/TRHR/PLCG1/FGF4/ERBB4/EDNRA/GRIN2A/CALM3/KDR/PHKA1/PPP3R1/NTRK2/FGF2/FGF22/CAMK1G/GRIN1/FGF20/SPHK1/CD38/CACNA1G/ITPKA/FGF9/CACNA1E/PDGFA/EDNRB/CACNA1I/MYLK4/RYR2/VDAC1/CACNA1B/FGFR1/ADRA1B/BDKRB1/CACNA1A/ADRB1/P2RX2/CYSLTR1/GDNF/CAMK4/ERBB3/PTGER1/GRM1/NOS2/NOS1/ADCY3/P2RX5/PLCE1/PDE1C/ADRB3/AVPR1B/PDGFRA/MCOLN3/FGF8/ADCY1/CCKAR/MCOLN2/GNA14/FGFR3/EGFR/GNAL/MET/ADCY2/GRM5/SLC8A2/CYSLTR2	231
KEGG	hsa05163	Human cytomegalovirus infection	217/6806	225/8135	9.436e-10	3.94e-08	1.44e-08	IFNA2/GNG13/IFNB1/IFNA1/IFNA13/HLA-E/CREB3/GNAQ/CASP9/ATF4/GRB2/GNB1/CCND1/GNA13/GNG2/RAC1/CALML6/PPP3R2/MAP2K2/CRKL/GNG5/RHOA/PLCB2/GNB2/MAPK14/ADCY8/IL1B/BAX/GNAI1/CASP3/ARHGEF1/PRKCB/MDM2/TSC2/TSC1/TAPBP/MAPK1/PIK3CB/PTK2B/BAK1/RHEB/IKBKG/BCAR1/ATF6B/PIK3CD/PRKACA/AKT3/IL6R/PTGS2/TBK1/IL10RA/NFATC1/HRAS/FADD/RAF1/TNFRSF1A/CALM1/RPS6KB2/ITPR3/E2F1/NFKBIA/EIF4EBP1/HLA-C/RAC2/RIPK1/CCL4/GNA11/TAP1/GNGT2/ROCK1/BID/IRF3/MTOR/MAPK3/PXN/PIK3CA/NFKB1/HLA-B/MAPK12/JAK1/HLA-A/FAS/CALML4/GNG3/PIK3R2/ROCK2/TNF/MAPK13/IKBKB/GNG8/GNG7/GNG10/TRADD/PTGER2/ELK1/TRAF2/IL10RB/IFNA8/AKT2/PIK3R1/CCR1/CASP8/GNAI2/CALML5/ADCY6/B2M/MAP2K6/CXCR2/SOS1/ARHGEF11/PPP3CA/GNAI3/PTGER4/GNAS/GSK3B/NFATC2/GNB3/PLCB4/AKT1/SOS2/NRAS/CCL5/ITPR1/GNAO1/MYC/GNG11/CDKN2A/CRK/CALML3/GNG12/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/PPP3CB/IFNA16/HLA-F/PDIA3/GNB5/MAPK11/ITPR2/ADCY9/ADCY4/CHUK/VEGFA/CREB3L4/TAP2/IL1R1/CALR/PPP3CC/KRAS/CREB3L2/PLCB3/AKAP13/RPS6KB1/CYCS/CXCR4/PRKACB/RB1/PRKACG/PTGER3/FASLG/PTK2/CREB5/CDK6/CTNNB1/TP53/E2F3/CREB3L1/CALM2/PLCB1/PRKCG/GNGT1/CDKN1A/ITGAV/RELA/ADCY7/ITGB3/GNA12/ATF2/PRKCA/CREB1/IFNA17/STAT3/CALM3/PPP3R1/CCR3/SRC/NFATC3/PIK3R3/GNB4/TRAF5/CCL2/IL6/GNG4/CXCL12/ADCY5/MAP2K1/PTGER1/CCL3/CCL3L1/CCL3L3/SP1/ADCY3/PDGFRA/RAC3/ADCY1/CREB3L3/EGFR/ADCY2/CCR5/NFATC4	217
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	214/6806	222/8135	1.468e-09	5.448e-08	1.992e-08	IL2/SLC25A31/HLA-E/CD40/RANBP3/ITGB2/CREB3/TLN1/ATF4/KAT5/CCND1/TGFB1/IL2RG/ZFP36/PPP3R2/SRF/MAP2K2/RAN/TGFB2/MAP3K3/ANAPC10/CRTC1/FDPS/CD4/SLC25A4/ADCY8/LTBR/BAX/VDAC2/MAPK1/ANAPC2/PIK3CB/STAT5B/POLB/ANAPC7/GPS2/PTTG2/SLC25A5/SPI1/JAK3/IKBKG/ANAPC1/ATF6B/ITGAL/PIK3CD/PRKACA/AKT3/NFATC1/HRAS/STAT5A/TNFRSF1A/HLA-DRA/TSPO/KAT2B/RELB/E2F1/NFKBIA/EP300/HLA-C/VAC14/IL2RA/SMAD4/CRTC2/MAPK3/PIK3CA/NFKB1/HLA-B/ANAPC16/PTEN/SMAD3/ETS2/MAP2K4/JAK1/TBPL1/HLA-A/CDK2/TERT/PIK3R2/XIAP/NFKB2/FOS/TNF/MAPK9/IKBKB/MAD1L1/RANBP1/ANAPC5/PTTG1/ELK1/ATM/ANAPC13/CDC27/AKT2/CCND3/TGFBR2/PIK3R1/CHEK2/CD3D/CSF2/ADCY6/B2M/CDKN2C/CRTC3/ANAPC4/SMAD2/CDC26/PPP3CA/NFATC2/JUN/AKT1/HLA-DMA/NRAS/ICAM1/MYC/ANAPC11/CD3G/CDKN2A/VDAC3/CCND2/HLA-G/IL1R2/CDK4/PPP3CB/IL15/HLA-F/HLA-DRB1/HLA-DRB4/ADCY9/HLA-DQB1/ADCY4/CHUK/CREB3L4/TLN2/HLA-DMB/SLC25A6/TBP/IL1R1/CALR/CDKN2B/LCK/HLA-DRB3/HLA-DRB5/PPP3CC/MAP3K14/KRAS/CREB3L2/ATR/PRKACB/RB1/LTA/PRKACG/IL2RB/XPO1/EGR1/CREB5/HLA-DOA/TP53/MAPK8/E2F3/CDC16/CREB3L1/CCNA2/CANX/BUB1B/BCL2L1/CDKN1A/RELA/ADCY7/SLC2A1/DLG1/ATF2/CREB1/ELK4/ETS1/HLA-DPA1/PPP3R1/TGFBR1/CCNE1/CCNE2/TCF3/MAPK10/NFATC3/IL15RA/PIK3R3/HLA-DPB1/NFYB/MSX2/TRRAP/CCNB2/VDAC1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/MAP3K1/CREBBP/ADCY5/CDC23/BUB3/CD3E/MAP2K1/KAT2A/ADCY3/TGFB3/ADCY1/CREB3L3/EGR2/FOSL1/CCNA1/ADCY2/ESPL1/MSX1/CHEK1/NFATC4	214
KEGG	hsa05145	Toxoplasmosis	112/6806	112/8135	1.813e-09	6.055e-08	2.214e-08	IL12A/CD40/LAMB1/BAD/CASP9/NFKBIB/TGFB1/TGFB2/IFNGR2/MAPK14/PIK3R5/GNAI1/CASP3/TYK2/MAPK1/IRAK1/IKBKG/MYD88/AKT3/LAMA2/IL10RA/TNFRSF1A/HLA-DRA/NFKBIA/IRAK4/MAP3K7/HSPA1L/MAPK3/NFKB1/MAPK12/HSPA6/TRAF6/JAK1/XIAP/TNF/MAPK13/MAPK9/IKBKB/LAMA3/HSPA8/HSPA1B/IL10RB/PPIF/TAB2/AKT2/CASP8/GNAI2/MAP2K6/LDLR/GNAI3/TAB1/JAK2/AKT1/HLA-DMA/LAMA1/GNAO1/HSPA1A/LAMC3/PIK3CG/BIRC7/MAPK11/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/BIRC2/CHUK/HLA-DMB/ITGB1/IL10/IFNG/HLA-DRB3/HLA-DRB5/TLR2/CYCS/IFNGR1/PDPK1/CIITA/PIK3R6/LY96/ALOX5/HLA-DOA/LAMC1/MAPK8/BCL2L1/RELA/LAMA5/LAMB4/STAT3/LAMB2/HLA-DPA1/TLR4/CD40LG/MAPK10/LAMC2/IRGM/HLA-DPB1/BCL2/STAT1/SOCS1/MAP2K3/HLA-DOB/HLA-DQA1/HLA-DQA2/HSPA2/LAMB3/BIRC3/NOS2/TGFB3/ITGA6/LAMA4/CCR5	112
KEGG	hsa04936	Alcoholic liver disease	140/6806	142/8135	3.347e-09	1.016e-07	3.715e-08	ADIPOQ/IFNA2/IFNB1/IFNA1/IFNA13/ADH1B/IL12A/ADH7/ADIPOR2/PPARA/CCND1/CPT1C/MAPK14/TICAM1/IL1B/ADH5/ACADVL/CASP3/ADH1A/CPT1A/CD14/IRAK1/ALDH9A1/IKBKG/ALDH2/MYD88/AKT3/TBK1/TRA2B/FADD/TRAF3/TNFRSF1A/PRKAB1/IL17RA/NFKBIA/RIPK1/IRAK4/MAP3K7/IRF3/C2/NFKB1/MAPK12/TRAF6/MAP2K4/C3/FAS/MLYCD/C5AR1/TNF/MAPK13/MAPK9/IKBKB/ACOX1/PRKAG2/TRADD/IL17A/IFNA8/TAB2/AKT2/FOXO1/CASP8/MAP3K5/MAP2K6/ALDH1B1/C1QB/GSK3B/TAB1/CXCL1/SIRT1/ALDH3A2/AKT1/TCF7/C1QA/LPIN3/PRKAA1/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/C3AR1/TIRAP/ALDH7A1/MAPK11/IL12B/NOX4/CHUK/SREBF1/CXCL3/IKBKE/TAB3/PRKAG1/MAP3K14/LPIN2/FASLG/LY96/CTNNB1/MAP2K7/FASN/MAPK8/RELA/CAMKK2/C5/ACACA/IFNA17/SCD5/CPT1B/FOXO3/TLR4/LPIN1/ADH4/MAPK10/LEF1/ACOX3/TRA2A/TCF7L2/ADIPOR1/ACADM/PRKAG3/CYP2E1/ACACB/MAP2K3/PRKAB2/IL6/C4A/C4B/SCD/ADH1C/PRKAA2/TCF7L1/C1QC/FABP1/LBP/CXCL2/ADH6/IL17RC/PPARGC1A	140
KEGG	hsa04659	Th17 cell differentiation	108/6806	108/8135	3.74e-09	1.041e-07	3.806e-08	IL2/NFKBIB/TGFB1/IL2RG/PPP3R2/IFNGR2/CD4/MAPK14/RUNX1/IL1B/STAT6/TYK2/EBI3/MAPK1/STAT5B/IL27RA/JAK3/IKBKG/RXRB/IL4R/IL6R/NFATC1/STAT5A/HLA-DRA/NFKBIA/IL2RA/SMAD4/MTOR/MAPK3/NFKB1/MAPK12/SMAD3/RARA/JAK1/NFKBIE/IL23A/RXRA/FOS/MAPK13/MAPK9/IKBKB/HSP90AB1/IL17A/IL4/TGFBR2/CD3D/IL6ST/IL12RB1/SMAD2/PPP3CA/RORC/NFATC2/JUN/JAK2/PRKCQ/HLA-DMA/CD3G/FOXP3/PPP3CB/MAPK11/HLA-DRB1/HLA-DRB4/HLA-DQB1/IL21R/CHUK/HLA-DMB/LAT/IL1R1/IFNG/IL1RAP/LCK/HLA-DRB3/HLA-DRB5/PPP3CC/IFNGR1/GATA3/IL2RB/CD247/ZAP70/HIF1A/HLA-DOA/MAPK8/AHR/IRF4/IL22/HSP90AA1/TBX21/RELA/IL21/PLCG1/STAT3/IL27/HLA-DPA1/PPP3R1/RORA/TGFBR1/MAPK10/NFATC3/HLA-DPB1/RXRG/STAT1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/CD3E/IL23R/IL17F	108
KEGG	hsa05152	Tuberculosis	175/6806	180/8135	4.264e-09	1.095e-07	4.005e-08	IFNA2/IFNB1/IFNA1/IFNA13/IL12A/ATP6V1H/PIK3C3/ATP6V0D1/CD209/ITGB2/BAD/CASP9/CAMK2G/PLK3/LAMP2/TGFB1/CALML6/PPP3R2/TGFB2/IFNGR2/CARD9/RHOA/MAPK14/IL1B/TLR1/BAX/CORO1A/CASP3/RAB5B/MAPK1/CD14/ATP6V0A1/IRAK1/ATP6AP1/SYK/LSP1/VDR/MYD88/AKT3/FCGR2A/IL10RA/MRC2/RIPK2/FADD/RAF1/TNFRSF1A/HLA-DRA/CALM1/EP300/IRAK4/TCIRG1/BID/CEBPB/ITGAM/MAPK3/CTSS/NFKB1/MAPK12/RFXAP/ATP6V0B/TRAF6/TLR9/C3/JAK1/IL23A/CALML4/TNF/MAPK13/MAPK9/ATP6V0A2/APAF1/TRADD/NOD2/IL10RB/IFNA8/CD74/ITGAX/AKT2/CASP8/HSPD1/CLEC4M/CALML5/ATP6V0D2/NFYC/FCGR2C/FCER1G/ATP6V0C/PPP3CA/MALT1/JAK2/CTSD/CAMP/KSR1/AKT1/HLA-DMA/NFYA/EEA1/CAMK2A/CALML3/RFXANK/RAB5A/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PPP3CB/CYP27B1/IFNA16/TIRAP/MAPK11/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/CLEC4E/HLA-DMB/IL10/CAMK2B/CASP10/CLEC7A/IFNG/HLA-DRB3/HLA-DRB5/PPP3CC/TLR2/RAB5C/CYCS/IFNGR1/CIITA/TLR6/FCGR1A/CAMK2D/HLA-DOA/SPHK2/FCGR3B/FCGR3A/MAPK8/PLA2R1/CR1L/CALM2/RELA/IL18/CREB1/IFNA17/CALM3/HLA-DPA1/PPP3R1/TLR4/HSPA9/SRC/FCGR2B/SPHK1/MAPK10/HLA-DPB1/CR1/RFX5/NFYB/BCL2/STAT1/RAB7A/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/LAMP1/ATP6V0A4/CREBBP/BCL10/NOS2/TGFB3/LBP/IL1A	175
KEGG	hsa04080	Neuroactive ligand-receptor interaction	331/6806	353/8135	4.716e-09	1.125e-07	4.114e-08	GABRA6/PTH/TAAR1/VIP/TAC1/GABRE/FSHR/TAAR9/MAS1/NPBWR2/NMBR/DRD5/LHCGR/HTR1D/PATE2/GALP/TAAR2/GRPR/CHRNA9/CHRM2/GABRA4/GPR50/GHR/HTR2C/MC4R/GABRR1/ADORA2A/ADRA1D/GHRH/NMUR2/NPFFR2/THRB/CHRNB4/GPR83/PTAFR/NPFF/P2RY4/GABRA2/NPY1R/GABRG2/GABRB1/CRHR1/RXFP3/GRM6/GPR35/HRH2/MCHR2/GCG/ADRA1A/CHRNA10/NTSR2/OXTR/TACR3/RXFP2/CALCR/CHRNA4/ADM/ADORA2B/F2R/HRH1/GNRH1/UCN3/MC3R/CHRNA3/HTR6/APLN/CHRM3/GHRL/GRIA2/CRH/SSTR5/HTR2A/TRH/LPAR4/TSPO/OPRK1/MC2R/S1PR4/CHRND/HTR2B/ADRA2B/VIPR2/CCKBR/GABRP/ADM2/GLP1R/MC1R/CALCA/C3/P2RX7/F2RL3/MTNR1B/P2RX4/C5AR1/GLP2R/GLRA1/CHRM4/LPAR2/ADORA3/GAL/PTGER2/CHRNB2/PLG/GRIK5/P2RY13/P2RX6/KISS1/PARD3/RXFP1/SSTR3/FPR1/CHRNE/LTB4R2/UCN2/GCGR/HTR7/NMUR1/LPAR1/GRIK1/GABBR1/GPHA2/GRM3/BRS3/P2RX3/PTGFR/CORT/LHB/PTGER4/HCRTR1/CHRNA7/GRM4/GRM2/F2RL1/HTR5A/LPAR6/P2RY6/AGTR1/PATE1/GABRA1/CHRNA2/ADORA1/P2RX1/CALCB/SLURP1/GRID2/HTR1F/P2RY8/CGA/CHRNB3/GRIN2D/TACR2/SST/AVPR2/LYPD6B/C3AR1/NR3C1/LEP/TAAR8/P2RY2/DRD1/SSTR1/PRLR/THRA/PTGDR/EDN1/MC5R/KNG1/TBXA2R/INSL3/PTH2/POMC/LTB4R/PTGER3/GRIN2C/ADCYAP1R1/S1PR3/GRM8/AVP/GRIN2B/P2RY10/GPHB5/UCN/ADRB2/GLRA3/OPRL1/GALR2/CHRM5/CHRM1/GZMA/AGTR2/TRPV1/CHRNA5/PRLH/HTR1A/MCHR1/SCT/GABRA3/HCRT/ADRA2C/DRD3/TAC4/PRLHR/AVPR1A/TACR1/P2RY11/PPY/C5/GABRR2/CALCRL/GRIN3B/TRHR/PTGIR/HTR1B/S1PR5/GABRG1/EDNRA/GRIN2A/FSHB/CRHR2/MTNR1A/IAPP/OPRD1/GRIN3A/F2/HCRTR2/GRIN1/GABRG3/GRIK3/HTR1E/NPBWR1/GABRB3/CNR2/GRP/GABBR2/APLNR/CHRNA6/NPY5R/HRH3/SSTR4/FPR2/S1PR2/NPFFR1/NPB/GABRD/CHRNA1/GNRHR/GRIA1/DRD2/TSHB/VIPR1/EDNRB/CHRNB1/CCK/TAAR5/S1PR1/GRIK2/RLN3/P2RY14/GRIA4/GHSR/RLN2/ADCYAP1/GH1/GH2/ADRA1B/PYY/GABRR3/BDKRB1/F2RL2/OPRM1/MLNR/GRIA3/GPR156/EDN2/DRD4/GALR3/FPR3/ADRB1/P2RX2/CYSLTR1/RLN1/GHRHR/GABRA5/PTH2R/LPAR3/UTS2R/GRIK4/GLRA2/GALR1/PTGER1/NMB/GRM7/PTH1R/GRM1/LYNX1/CSH1/GNRH2/EDN3/UTS2/P2RX5/OXT/ADRB3/AVPR1B/PRSS2/PRSS3/ADRA2A/NMU/PRL/INSL5/MLN/LEPR/GIPR/CCKAR/CTSG/PMCH/NPY/NTS/GABRB2/CNR1/CSH2/CHRNG/KISS1R/NPY2R/NPW/AGT/TAC3/SCTR/PENK/GRM5/SSTR2/CYSLTR2	331
KEGG	hsa05169	Epstein-Barr virus infection	195/6806	202/8135	5.317e-09	1.184e-07	4.328e-08	IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/CD40/PSMD6/CASP9/BCL2L11/NFKBIB/CCND1/RAC1/USP7/BTK/HDAC2/PSMD13/MAPK14/BAX/CASP3/MDM2/TAPBP/PSMC4/TYK2/GADD45B/PSMC1/HDAC1/PIK3CB/BAK1/IRAK1/PSMD7/SAP30L/SYK/PSMD12/PSMC6/JAK3/IKBKG/MYD88/ITGAL/PIK3CD/AKT3/PSMD4/TBK1/FADD/TRAF3/HLA-DRA/MAVS/IFNAR1/RELB/E2F1/NFKBIA/HLA-C/RIPK1/TAP1/IRAK4/PSMD1/MAP3K7/TNFAIP3/BID/IRF3/PLCG2/PIK3CA/NFKB1/HLA-B/MAPK12/PSMC2/TRAF6/PSMC5/CD58/MAP2K4/JAK1/SIN3A/NFKBIE/HLA-A/FAS/CDK2/PSMD11/PIK3R2/CIR1/NFKB2/TNF/MAPK13/MAPK9/IKBKB/APAF1/PSMD8/PSMD2/TRADD/VIM/TRAF2/IFNA8/TAB2/AKT2/CCND3/PIK3R1/SKP2/CD3D/CASP8/PSMC3/CDKN1B/B2M/ADRM1/LYN/MAP2K6/ENTPD1/SNW1/TAB1/JUN/AKT1/HLA-DMA/ENTPD3/ICAM1/MYC/HES1/PSMD3/CD3G/DDB2/CD19/POLK/RUNX3/CCND2/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/IFNA16/HLA-F/RBPJ/PDIA3/MAPK11/IRF9/HLA-DRB1/HLA-DRB4/HLA-DQB1/CHUK/FCER2/HLA-DMB/CD44/TAP2/IKBKE/CALR/HLA-DRB3/HLA-DRB5/TLR2/MAP3K14/CYCS/RB1/NEDD4/CD247/PSMD14/HLA-DOA/CDK6/MAP2K7/TP53/MAPK8/E2F3/SAP30/GADD45A/CCNA2/CDKN1A/RELA/DDX58/IFNA17/STAT3/HLA-DPA1/CCNE1/CCNE2/MAPK10/STAT2/RBPJL/GADD45G/PIK3R3/HLA-DPB1/TRAF5/IRF7/BCL2/STAT1/MAP2K3/NCOR2/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/BLNK/CD3E/EIF2AK2/ISG15/CCNA1/IFNAR2/CR2/OAS1	195
KEGG	hsa04910	Insulin signaling pathway	135/6806	137/8135	7.737e-09	1.615e-07	5.904e-08	GYS2/PPP1R3A/BAD/PTPN1/GRB2/PPP1R3D/RPTOR/CALML6/MAP2K2/CRKL/EIF4E2/INPPL1/FLOT1/TSC2/TSC1/FLOT2/MAPK1/PIK3CB/ARAF/FBP1/HK3/PHKG2/PHKB/RHEB/PIK3CD/PRKACA/AKT3/SHC1/PHKA2/HRAS/PPP1CA/RHOQ/EXOC7/RAF1/CALM1/RPS6KB2/PRKAB1/EIF4EBP1/SHC3/PCK1/SH2B2/MTOR/MAPK3/PIK3CA/PYGM/PPP1CB/PHKG1/G6PC/CALML4/PYGL/PIK3R2/GCK/MAPK9/IKBKB/IRS2/PRKAG2/ELK1/GYS1/PPP1CC/AKT2/FOXO1/PIK3R1/G6PC3/CALML5/INPP5A/SOS1/GSK3B/PRKCZ/AKT1/SOS2/NRAS/HK2/HKDC1/PRKAA1/PRKAR1A/RAPGEF1/CRK/CALML3/G6PC2/PPP1R3B/IRS4/RPS6/IRS1/PCK2/SREBF1/PPP1R3C/PRKAG1/PYGB/PKLR/CBLB/KRAS/PPP1R3F/RPS6KB1/PPP1R3E/PRKACB/PRKACG/SOCS4/PDPK1/BRAF/INS/PRKCI/MKNK1/PDE3B/FASN/MAPK8/HK1/INSR/PTPRF/SOCS3/CALM2/EIF4E/ACACA/MKNK2/CALM3/PHKA1/PRKAR1B/SHC4/MAPK10/PIK3R3/PRKAR2A/PRKAG3/PRKAR2B/ACACB/SOCS1/PRKAB2/FBP2/SORBS1/MAP2K1/CBL/PRKAA2/SHC2/LIPE/SLC2A4/SOCS2/PPARGC1A	135
KEGG	hsa05161	Hepatitis B	158/6806	162/8135	1.029e-08	2.022e-07	7.392e-08	IFNA2/IFNB1/IFNA1/IFNA13/CREB3/BAD/CASP9/ATF4/GRB2/TGFB1/MAP2K2/TGFB2/MAPK14/TICAM1/BAX/CASP3/PRKCB/STAT6/TYK2/MAPK1/PIK3CB/STAT5B/ARAF/PTK2B/IRAK1/ATP6AP1/HSPG2/JAK3/IKBKG/MYD88/ATF6B/PIK3CD/AKT3/TBK1/NFATC1/HRAS/STAT5A/FADD/RAF1/TRAF3/MAVS/IFNAR1/E2F1/NFKBIA/EP300/IRAK4/MAP3K7/BID/IRF3/SMAD4/MAPK3/PIK3CA/NFKB1/MAPK12/TRAF6/SMAD3/MAP2K4/JAK1/FAS/CDK2/PIK3R2/FOS/TNF/MAPK13/MAPK9/IKBKB/APAF1/ELK1/YWHAQ/IFNA8/TAB2/AKT2/TGFBR2/PIK3R1/CASP8/DDX3X/YWHAZ/DDB1/PCNA/MAP2K6/SOS1/TAB1/NFATC2/JUN/JAK2/AKT1/SOS2/NRAS/MYC/CASP12/DDB2/STAT4/YWHAB/VDAC3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/TIRAP/MAPK11/CHUK/CREB3L4/CASP10/IKBKE/MMP9/TLR2/KRAS/CREB3L2/CYCS/RB1/FASLG/CREB5/BRAF/SLC10A1/MAP2K7/TP53/MAPK8/E2F3/CREB3L1/CCNA2/PRKCG/CDKN1A/RELA/DDX58/ATF2/PRKCA/CREB1/IFNA17/STAT3/TLR4/SRC/TGFBR1/CCNE1/CCNE2/MAPK10/NFATC3/STAT2/PIK3R3/IFIH1/IRF7/BCL2/STAT1/MAP2K3/IL6/TICAM2/MAP3K1/CREBBP/MAP2K1/TGFB3/CREB3L3/EGR2/CCNA1/BIRC5/NFATC4	158
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	187/6806	194/8135	1.729e-08	3.135e-07	1.146e-07	IFNA2/GNG13/IFNB1/IFNA1/IFNA13/HLA-E/PIK3C3/CASP9/GNB1/CCND1/GNG2/UBC/RAC1/CALML6/ZFP36/PPP3R2/MAP2K2/GNG5/GNB2/MAPK14/TICAM1/PIK3R5/BAX/CASP3/TYK2/BECN1/MAPK1/PIK3CB/BAK1/ANGPT2/SYK/IKBKG/PIK3CD/AKT3/PTGS2/TBK1/NFATC1/HRAS/MAP1LC3A/FADD/RAF1/TRAF3/MAP1LC3B/TNFRSF1A/CALM1/ITPR3/IFNAR1/E2F1/NFKBIA/EP300/HLA-C/GNGT2/BID/IRF3/MTOR/PLCG2/CLEC2B/MAPK3/MAP1LC3C/UBA52/PIK3CA/NFKB1/HLA-B/MAPK12/MAP2K4/C3/JAK1/HCK/HLA-A/FAS/CALML4/GNG3/PIK3R2/FOS/MAPK13/MAPK9/IKBKB/MAPKAPK2/GNG8/GNG7/GNG10/TRADD/MICA/TRAF2/ATG3/IFNA8/AKT2/PIK3R1/IL6ST/CCR1/CASP8/CALML5/CSF2/LYN/MAP2K6/PPP3CA/GSK3B/CXCL1/NFATC2/JUN/JAK2/GNB3/AKT1/TCF7/NRAS/ITPR1/MAP1LC3B2/ICAM1/MYC/GNG11/PDGFB/CALML3/GNG12/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/PREX1/PPP3CB/IFNA16/HLA-F/GNB5/PIK3CG/MAPK11/IRF9/ITPR2/CHUK/VEGFA/CXCL3/IKBKE/CD86/PPP3CC/KRAS/CYCS/RB1/IFNGR1/RCAN1/HIF1A/PIK3R6/CDK6/CTNNB1/MAP2K7/TP53/MAPK8/E2F3/CALM2/GNGT1/CDKN1A/RELA/CREB1/PLCG1/UBB/IFNA17/STAT3/CALM3/PPP3R1/FGF2/CCR3/SRC/RPS27A/MAPK10/LEF1/NFATC3/STAT2/PIK3R3/TCF7L2/GNB4/IRF7/STAT1/IL6/GNG4/CCR4/CREBBP/MICB/MAP2K1/EIF2AK2/CD200R1/TCF7L1/IFNAR2/CXCL2/CCR5/NFATC4	187
KEGG	hsa04728	Dopaminergic synapse	130/6806	132/8135	1.783e-08	3.135e-07	1.146e-07	GNG13/DRD5/CLOCK/CREB3/GNAQ/ATF4/PPP2CA/PPP2R5D/CAMK2G/ARRB1/GNB1/PPP2R5C/KCNJ6/GNG2/PPP2R2D/CALML6/GNG5/PLCB2/GNB2/MAPK14/CACNA1C/PPP2R2C/GNAI1/PRKCB/ARRB2/COMT/GRIA2/PPP2R2A/ATF6B/PRKACA/AKT3/GSK3A/PPP1CA/CALM1/ITPR3/ARNTL/PPP2R1A/GNGT2/MAPK12/PPP1CB/CALML4/GNG3/PPP2R5B/FOS/MAPK13/MAPK9/GNG8/KCNJ5/GNG7/GNG10/PPP1CC/AKT2/CALY/GNAI2/CALML5/KIF5B/KIF5C/PPP3CA/GNAI3/GNAS/GSK3B/GNB3/PLCB4/AKT1/ITPR1/GNAO1/GNG11/PPP2R3C/CAMK2A/CALML3/GNG12/PPP2R5A/PPP3CB/GNB5/MAPK11/ITPR2/PPP2R5E/CREB3L4/DRD1/CAMK2B/MAOA/PPP2R3A/PPP3CC/PPP2R2B/CREB3L2/PLCB3/PRKACB/PPP2R3B/PRKACG/GRIN2B/CREB5/CAMK2D/CACNA1D/PPP2CB/MAPK8/LRTOMT/CREB3L1/TH/CALM2/PLCB1/PRKCG/GNGT1/KCNJ3/DRD3/ATF2/PRKCA/CREB1/GRIN2A/CALM3/SCN1A/MAPK10/SLC18A2/GNB4/GRIA1/SLC18A1/DRD2/GRIA4/KIF5A/CACNA1B/GNG4/GRIA3/PPP1R1B/DRD4/ADCY5/CACNA1A/MAOB/SLC6A3/CREB3L3/GNAL/KCNJ9	130
KEGG	hsa04068	FoxO signaling pathway	129/6806	131/8135	2.106e-08	3.518e-07	1.286e-07	CCNB3/IGF1/FBXO32/FOXG1/BCL2L11/GRB2/PLK3/CCND1/TGFB1/USP7/MAP2K2/TGFB2/MAPK14/CSNK1E/MDM2/CAT/FBXO25/GADD45B/MAPK1/PIK3CB/ARAF/BCL6/SETD7/HOMER3/PIK3CD/AKT3/PRMT1/GABARAPL2/HRAS/RAF1/PRKAB1/EP300/S1PR4/PCK1/SMAD4/STK11/AGAP2/MAPK3/PIK3CA/STK4/MAPK12/CDKN2D/PTEN/SMAD3/G6PC/ATG12/CDK2/PIK3R2/MAPK13/MAPK9/IKBKB/IRS2/PRKAG2/GABARAP/SGK3/IGF1R/ATM/BNIP3/AKT2/TGFBR2/FOXO1/PIK3R1/SKP2/G6PC3/CDKN1B/RAG1/GABARAPL1/SOS1/SOD2/SIRT1/AKT1/SOS2/NRAS/FOXO6/PRKAA1/CCND2/G6PC2/MAPK11/IRS4/CHUK/IRS1/PCK2/IL10/CDKN2B/SGK1/PRKAG1/KRAS/PLK4/FASLG/IL7R/FOXO4/PDPK1/BRAF/INS/MAPK8/INSR/KLF2/GADD45A/EGF/RBL2/CDKN1A/SGK2/TNFSF10/STAT3/FOXO3/TGFBR1/HOMER1/MAPK10/GADD45G/PIK3R3/PRKAG3/S1PR1/CCNB2/PRKAB2/IL6/CCNG2/CREBBP/MAP2K1/GRM1/PRKAA2/RAG2/TGFB3/PLK2/CCNB1/PLK1/NLK/HOMER2/EGFR/SLC2A4	129
KEGG	hsa04218	Cellular senescence	152/6806	156/8135	2.642e-08	4.202e-07	1.536e-07	CCNB3/LIN54/SLC25A31/RASSF5/HLA-E/RAD9A/HIPK4/CCND1/TGFB1/CALML6/PPP3R2/MAP2K2/TGFB2/SLC25A4/MAPK14/LIN52/VDAC2/LIN37/MDM2/TSC2/TSC1/GADD45B/MAPK1/PIK3CB/SLC25A5/RHEB/RAD50/PIK3CD/AKT3/RRAS/NFATC1/HRAS/PPP1CA/RAF1/CALM1/ITPR3/E2F1/EIF4EBP1/HLA-C/SQSTM1/MTOR/MAPK3/PIK3CA/NFKB1/HLA-B/MAPK12/NBN/BTRC/PTEN/SMAD3/PPP1CB/HUS1/HLA-A/CDK2/CALML4/PIK3R2/TRAF3IP2/MAPK13/E2F4/MAPKAPK2/CDK1/ATM/PPP1CC/AKT2/CCND3/TGFBR2/FOXO1/PIK3R1/CHEK2/CALML5/KIR2DL4/MAP2K6/SMAD2/FBXW11/PPP3CA/NFATC2/SIRT1/AKT1/NRAS/ITPR1/ZFP36L2/RAD9B/MYC/HIPK1/CDKN2A/VDAC3/CALML3/CCND2/HLA-G/CDK4/PPP3CB/HLA-F/MAPK11/ITPR2/SLC25A6/RBBP4/CDKN2B/PPID/PPP3CC/MYBL2/KRAS/HIPK3/ATR/RB1/CAPN2/RAD1/FOXM1/CACNA1D/CDK6/TP53/E2F3/SERPINE1/GADD45A/CCNA2/CALM2/RBL2/CDKN1A/RELA/ZFP36L1/CALM3/ETS1/PPP3R1/FOXO3/TGFBR1/CCNE1/CCNE2/NFATC3/TRPM7/GADD45G/PIK3R3/HIPK2/RRAS2/CCNB2/MAP2K3/VDAC1/IL6/E2F5/MAP2K1/TRPV4/RBL1/GATA4/TGFB3/LIN9/MRAS/CCNB1/CCNA1/CAPN1/CDC25A/CHEK1/IGFBP3/NFATC4/IL1A	152
KEGG	hsa04926	Relaxin signaling pathway	127/6806	129/8135	2.938e-08	4.461e-07	1.631e-07	GNG13/CREB3/ATF4/GRB2/GNA15/ARRB1/GNB1/RXFP3/GNG2/TGFB1/MAP2K2/GNG5/PLCB2/GNB2/MAPK14/ADCY8/GNAI1/RXFP2/ARRB2/MAPK1/PIK3CB/VEGFC/ATF6B/PIK3CD/PRKACA/AKT3/SHC1/HRAS/RAF1/NFKBIA/SHC3/GNGT2/MAPK3/PIK3CA/NFKB1/MAPK12/MAP2K4/GNG3/PIK3R2/FOS/MAPK13/MAPK9/GNG8/GNG7/GNG10/NOS3/RXFP1/AKT2/TGFBR2/PIK3R1/GNAI2/ADCY6/SMAD2/SOS1/VEGFB/GNAI3/GNAS/JUN/PRKCZ/GNB3/PLCB4/AKT1/SOS2/NRAS/GNAO1/COL4A3/GNG11/GNG12/COL4A2/GNB5/MAPK11/ADCY9/ADCY4/VEGFA/CREB3L4/MMP9/ACTA2/KRAS/EDN1/CREB3L2/PLCB3/INSL3/PRKACB/COL4A5/PRKACG/COL4A6/CREB5/MAP2K7/MAPK8/CREB3L1/PLCB1/GNGT1/RELA/COL1A1/ADCY7/MMP2/ATF2/PRKCA/CREB1/SHC4/SRC/TGFBR1/MMP13/MAPK10/PIK3R3/MMP1/GNB4/COL4A1/EDNRB/RLN3/RLN2/GNG4/ADCY5/RLN1/MAP2K1/NOS2/NOS1/ADCY3/INSL5/COL4A4/ADCY1/COL3A1/CREB3L3/SHC2/EGFR/ADCY2/COL1A2	127
KEGG	hsa04380	Osteoclast differentiation	126/6806	128/8135	3.469e-08	5.038e-07	1.842e-07	IFNB1/NOX1/SIRPA/GRB2/TGFB1/RAC1/JUNB/BTK/LCP2/PPP3R2/TGFB2/LILRB5/IFNGR2/LILRB2/FYN/MAPK14/NCF4/IL1B/CALCR/TYK2/TYROBP/MAPK1/PIK3CB/NCF1/SPI1/SYK/IKBKG/LILRB3/TREM2/PIK3CD/FOSL2/AKT3/FCGR2A/NFATC1/LILRA1/NCF2/TNFRSF1A/IFNAR1/RELB/NFKBIA/CSF1R/CYLD/MAP3K7/SQSTM1/PLCG2/MAPK3/PIK3CA/NFKB1/MAPK12/TRAF6/TNFRSF11B/LILRA2/JAK1/LILRB4/TEC/PIK3R2/NFKB2/FOS/TNF/MAPK13/MAPK9/IKBKB/ACP5/TRAF2/CYBA/TAB2/AKT2/TGFBR2/PIK3R1/LILRA6/MAP2K6/FCGR2C/LILRB1/PPP3CA/TAB1/NFATC2/JUN/AKT1/SIRPB1/LILRA3/MITF/OSCAR/SIRPG/GAB2/PPP3CB/MAPK11/IRF9/CHUK/IL1R1/IFNG/CTSK/LCK/PPP3CC/MAP3K14/IFNGR1/FCGR1A/FCGR3B/MAP2K7/FCGR3A/MAPK8/SOCS3/RELA/ITGB3/CREB1/PPP3R1/TGFBR1/FCGR2B/LILRA5/MAPK10/STAT2/PIK3R3/FOSB/STAT1/SOCS1/JUND/LILRA4/BLNK/CAMK4/MAP2K1/CSF1/FHL2/TNFRSF11A/FOSL1/IFNAR2/PPARG/IL1A	126
KEGG	hsa05205	Proteoglycans in cancer	196/6806	205/8135	7.858e-08	1.094e-06	3.998e-07	WNT2/FZD10/WNT9B/TFAP4/IGF1/HSPB2/WNT3/ANK3/FZD2/PTPN6/CAMK2G/GRB2/VAV1/CCND1/ITGA5/TGFB1/IQGAP1/RAC1/VTN/ACTG1/ITGA2/MAP2K2/TGFB2/RHOA/MAPK14/PAK1/CASP3/ARHGEF1/PRKCB/WNT7A/MDM2/MAPK1/PIK3CB/WNT8B/ARAF/MSN/WNT16/HSPG2/TWIST2/WNT7B/GPC1/PIK3CD/PRKACA/AKT3/RRAS/HRAS/PPP1CA/RAF1/EZR/PPP1R12A/RPS6KB2/FZD1/ITPR3/WNT1/ROCK1/MTOR/CD63/PLCG2/MAPK3/PXN/PIK3CA/SHH/SLC9A1/MAPK12/WNT8A/PPP1CB/ACTB/FAS/FLNC/PIK3R2/ROCK2/CDC42/TNF/MAPK13/PPP1R12C/FZD9/ELK1/IGF1R/PPP1CC/PLAUR/AKT2/PIK3R1/MIR21/SDC2/PPP1R12B/FLNA/HCLS1/SMAD2/SOS1/RDX/AKT1/VAV2/SOS2/NRAS/HGF/ITPR1/HBEGF/MYC/THBS1/WNT10B/CAMK2A/MAPK11/ITPR2/IL12B/CTTN/PLAU/RPS6/VEGFA/ITGB1/CD44/TIAM1/CAMK2B/ERBB2/DDX5/MMP9/TLR2/KRAS/RPS6KB1/NUDT16L1/WNT4/PRKACB/PRKACG/FASLG/PTK2/EIF4B/HIF1A/ANK2/SDC1/PDPK1/BRAF/TWIST1/CAMK2D/CTNNB1/TP53/FRS2/FLNB/PRKCG/CDKN1A/ITGAV/COL1A1/ITGB3/HPSE2/MMP2/PRKCA/PLCG1/ERBB4/STAT3/PTCH1/KDR/HPSE/TIMP3/TLR4/FGF2/SRC/ESR1/WNT5B/FZD5/PIK3R3/FN1/WNT5A/FZD6/PDCD4/MIR10B/RRAS2/CAV2/HOXD10/SDC4/GPC3/PTPN11/FGFR1/ITGB5/IGF2/FZD7/FZD8/MAP2K1/CBL/ERBB3/FZD4/VAV3/PLCE1/ANK1/DCN/MRAS/WNT11/LUM/CAV1/EGFR/WNT2B/GAB1/MET/WNT9A/WNT10A/FZD3/WNT6/IHH/COL1A2	196
KEGG	hsa04062	Chemokine signaling pathway	184/6806	192/8135	1.106e-07	1.478e-06	5.403e-07	GNG13/GRK7/CCL25/GNAQ/BAD/GRB2/VAV1/ARRB1/GNB1/NFKBIB/GNG2/RAC1/CXCL13/CRKL/GNG5/RHOA/PLCB2/GNB2/ADCY8/PIK3R5/PAK1/GNAI1/PRKCB/ARRB2/MAPK1/PIK3CB/STAT5B/RASGRP2/PTK2B/ELMO1/GRK6/NCF1/DOCK2/JAK3/GRK5/IKBKG/BCAR1/PIK3CD/PRKACA/AKT3/SHC1/WAS/HRAS/GSK3A/RAF1/NFKBIA/SHC3/RAC2/CCL4/GNGT2/ROCK1/PLCG2/CCL27/PRKCD/MAPK3/PXN/PIK3CA/NFKB1/CCR2/CXCR3/CCL24/HCK/CCL28/CXCR1/GNG3/PIK3R2/ROCK2/CCL19/CDC42/IKBKB/GRK4/GNG8/GNG7/GNG10/PARD3/AKT2/PIK3R1/RAP1B/CCR1/XCR1/GNAI2/ADCY6/RAP1A/CCR7/LYN/CXCR2/SOS1/GNAI3/GSK3B/CXCL1/JAK2/PRKCZ/GNB3/PLCB4/AKT1/VAV2/SOS2/NRAS/CCL5/XCL1/XCL2/GNG11/CRK/GNG12/CX3CR1/PREX1/CCL21/GNB5/PIK3CG/ADCY9/ADCY4/CHUK/CXCL16/TIAM1/CXCL3/CXCR6/KRAS/PLCB3/CXCR4/PRKACB/PRKACG/PTK2/FGR/CCL1/BRAF/PIK3R6/CCL26/ITK/CCL14/CCL15/CCL13/PLCB1/GNGT1/RELA/CCL23/ADCY7/PPBP/CCR10/PLCG1/STAT3/CCL7/CCL18/PF4/GRK1/FOXO3/CCL20/SHC4/CXCR5/CCR3/SRC/STAT2/CXCL6/PIK3R3/CCL16/CCL17/GNB4/CXCL14/STAT1/CCL2/GNG4/CCL11/CCR4/CXCL12/CCR9/ADCY5/PF4V1/CXCL11/MAP2K1/CCL3/CCL3L1/CCL3L3/ADCY3/CCL22/VAV3/RAC3/ADCY1/CXCL9/CCL8/CXCL5/SHC2/ADCY2/CXCL2/CCR6/CCR5	184
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	105/6806	106/8135	1.183e-07	1.52e-06	5.555e-07	CYP24A1/GCM2/PTH/MMP14/NACA/CREB3/GNAQ/ATF4/LRP5/ARRB1/SLC9A3R1/GNA13/RHOA/PLCB2/ADCY8/GNAI1/ARHGEF1/PRKCB/PDE4D/ARRB2/MAPK1/ARAF/PDE4B/VDR/ATF6B/RXRB/PRKACA/SLC34A2/RAF1/ITPR3/GNA11/PLD1/MMP25/MAPK3/CASR/PLD2/FGF23/TRPV5/MEF2A/SOST/RXRA/BGLAP/FOS/PTHLH/GNAI2/ADCY6/ARHGEF11/GNAI3/GNAS/SLC34A1/PLCB4/MMP24/ITPR1/HBEGF/MMP16/CYP27B1/ITPR2/ADCY9/ADCY4/CREB3L4/MMP17/CREB3L2/PLCB3/AKAP13/PRKACB/PRKACG/GATA3/EGR1/CREB5/BRAF/CREB3L1/PLCB1/PRKCG/CDKN1A/ADCY7/MEF2C/GNA12/ATF2/PRKCA/CREB1/RUNX2/MMP15/MAFB/MEF2D/MMP13/NR4A2/GCM1/BCL2/PDE4A/RXRG/KL/PDE4C/FGFR1/JUND/SLC34A3/ADCY5/MAP2K1/PTH1R/SP1/ADCY3/LRP6/ADCY1/CREB3L3/EGFR/ADCY2	105
KEGG	hsa04152	AMPK signaling pathway	118/6806	120/8135	1.305e-07	1.614e-06	5.9e-07	ADIPOQ/GYS2/IGF1/ADIPOR2/CREB3/PPP2CA/PPP2R5D/PPP2R5C/CCND1/PPP2R2D/RPTOR/ADRA1A/CPT1C/EEF2/PPP2R2C/TSC2/TSC1/PIK3CB/CPT1A/FBP1/AKT1S1/RAB11B/RHEB/STRADA/PPP2R2A/CFTR/PIK3CD/AKT3/CAB39L/RPS6KB2/PRKAB1/RAB14/HMGCR/EIF4EBP1/PPP2R1A/PCK1/MAP3K7/CAB39/STK11/MTOR/CRTC2/PIK3CA/RAB10/G6PC/HNF4A/PIK3R2/PFKP/MLYCD/PPP2R5B/PFKM/IRS2/PRKAG2/IGF1R/GYS1/AKT2/FOXO1/PIK3R1/G6PC3/TBC1D1/CD36/ELAVL1/RAB8A/SIRT1/AKT1/RAB2A/PRKAA1/PPP2R3C/G6PC2/PPP2R5A/LEP/PPP2R5E/IRS4/CREB3L4/IRS1/PFKFB4/PCK2/SREBF1/PPP2R3A/PRKAG1/PPP2R2B/PFKFB2/CREB3L2/RPS6KB1/PPP2R3B/PDPK1/CREB5/INS/PPP2CB/PFKL/FASN/PFKFB3/ULK1/CREB3L1/INSR/CCNA2/CAMKK2/CREB1/ACACA/SCD5/CPT1B/FOXO3/PIK3R3/ADIPOR1/PRKAG3/ACACB/PRKAB2/FBP2/SCD/STRADB/PRKAA2/LEPR/CREB3L3/CCNA1/PPARG/LIPE/EEF2K/SLC2A4/PPARGC1A	118
KEGG	hsa04510	Focal adhesion	192/6806	201/8135	1.366e-07	1.629e-06	5.957e-07	TNN/COL6A6/IGF1/ITGA11/LAMB1/TLN1/BAD/GRB2/DIAPH1/VAV1/CCND1/ITGA5/RAC1/VTN/ACTG1/THBS4/ITGA2/VWF/CRKL/PARVG/FYN/RHOA/ITGB4/PAK1/PRKCB/VASP/PAK2/MAPK1/ZYX/PIK3CB/ILK/MYLK2/VCL/ACTN1/PDGFRB/VEGFC/BCAR1/MYLPF/PIK3CD/AKT3/SHC1/LAMA2/PARVB/HRAS/PPP1CA/RAF1/PPP1R12A/SHC3/RAC2/ITGA4/ROCK1/MAPK3/PXN/PIK3CA/PTEN/FLT4/PPP1CB/ACTB/PIP5K1C/ARHGAP5/FLNC/ITGA2B/PIK3R2/XIAP/COL6A1/ROCK2/CDC42/MAPK9/COL9A3/LAMA3/PPP1R12C/ACTN4/PDGFD/ITGA9/ELK1/THBS3/IGF1R/PPP1CC/AKT2/CCND3/PIK3R1/RAP1B/MYL12A/MYL12B/RAP1A/PPP1R12B/FLNA/COL9A1/SOS1/PDGFC/VEGFB/GSK3B/JUN/AKT1/TNXB/VAV2/SOS2/LAMA1/ITGA7/HGF/COL4A3/THBS1/MYL10/PDGFB/RAPGEF1/CRK/LAMC3/CCND2/PIP5K1A/COL4A2/ITGA10/ITGB7/BIRC2/VEGFA/TLN2/ITGB1/ERBB2/MYL9/COL6A3/MYLK3/COL4A5/CAPN2/COMP/PIP5K1B/COL4A6/PTK2/SPP1/PAK4/PDPK1/BRAF/CTNNB1/LAMC1/MAPK8/CHAD/PGF/EGF/COL9A2/MYLK/FLNB/PRKCG/FLT1/ITGAV/COL1A1/ITGB3/LAMA5/ITGA8/LAMB4/PRKCA/LAMB2/THBS2/KDR/ITGB8/SHC4/SRC/MYL7/PARVA/MAPK10/PAK3/LAMC2/MYL5/PIK3R3/DOCK1/FN1/PDGFA/MYL2/BCL2/COL4A1/RASGRF1/CAV2/MYLK4/ITGB5/PAK6/LAMB3/BIRC3/COL2A1/MAP2K1/VAV3/TNC/PDGFRA/COL4A4/TNR/RAC3/ITGA3/CAV1/SHC2/EGFR/ITGA6/MET/LAMA4/COL6A2/COL1A2/RELN	192
KEGG	hsa04024	cAMP signaling pathway	210/6806	221/8135	1.437e-07	1.656e-06	6.052e-07	VIP/CNGA3/FSHR/DRD5/FXYD1/LHCGR/HTR1D/CHRM2/CNGB3/ADORA2A/PPARA/CREB3/BAD/NPY1R/CAMK2G/VAV1/CRHR1/RAC1/CALML6/GCG/GLI3/MAP2K2/NPPA/RHOA/ADCY8/CACNA1C/OXTR/PAK1/GNAI1/PDE4D/F2R/MAPK1/PIK3CB/AMH/PDE4B/CNGA1/HTR6/CACNA1S/GHRL/GRIA2/CFTR/CRH/SSTR5/PIK3CD/PRKACA/ATP2B3/AKT3/RRAS/NFATC1/PPP1CA/ATP2A2/RAF1/CALM1/PPP1R12A/HCN2/NFKBIA/EP300/MC2R/ARAP3/RAC2/HHIP/PLD1/ROCK1/VIPR2/MAPK3/PIK3CA/PLD2/NFKB1/SLC9A1/ATP2A3/GLP1R/ATP1B3/PPP1CB/ATP2B2/CALML4/PIK3R2/ROCK2/FOS/NPR1/MAPK9/ACOX1/ORAI1/ATP2B1/PTGER2/ATP2B4/PPP1CC/AKT2/PIK3R1/RAP1B/CACNA1F/GNAI2/CALML5/ADCY6/RAP1A/PDE3A/GABBR1/GPHA2/GNAI3/LHB/GNAS/JUN/AKT1/VAV2/ADORA1/HTR1F/CAMK2A/CGA/ABCC4/GRIN2D/CALML3/SST/ADCY9/CNGA4/ADCY4/CREB3L4/CNGB1/DRD1/TIAM1/SSTR1/CAMK2B/ATP1A1/MYL9/BDNF/EDN1/CREB3L2/PRKACB/POMC/PRKACG/PTGER3/GRIN2C/PDE10A/ADCYAP1R1/FXYD2/GRIN2B/GPHB5/ADRB2/SOX9/CREB5/BRAF/FFAR2/CAMK2D/CACNA1D/PDE3B/CHRM1/MAPK8/PLN/CREB3L1/HTR1A/CALM2/RELA/ADCY7/GRIN3B/CREB1/HTR1B/EDNRA/GRIN2A/FSHB/PTCH1/CRHR2/CALM3/GRIN3A/GRIN1/HTR1E/GLI1/MAPK10/GABBR2/ACOX3/PIK3R3/HCN4/ATP1B1/GRIA1/DRD2/TSHB/PDE4A/RRAS2/RAPGEF3/GRIA4/GHSR/RYR2/RAPGEF4/ADCYAP1/PDE4C/GRIA3/EDN2/PPP1R1B/ATP1A4/CREBBP/ADCY5/ATP1A2/ADRB1/CAMK4/ATP1A3/MAP2K1/ATP1B4/ADCY10/ADCY3/VAV3/EDN3/PLCE1/OXT/GIPR/RAC3/ADCY1/NPY/CREB3L3/ADCY2/LIPE/TNNI3/SUCNR1/SSTR2	210
KEGG	hsa04022	cGMP-PKG signaling pathway	161/6806	167/8135	1.754e-07	1.953e-06	7.14e-07	KCNMB2/KCNU1/SLC25A31/ADRA1D/CREB3/GNAQ/BAD/ATF4/PRKG2/GNA13/CALML6/ADRA1A/PPP3R2/SRF/MAP2K2/NPPA/RHOA/PLCB2/SLC25A4/ADCY8/CACNA1C/PIK3R5/GNAI1/VDAC2/VASP/MAPK1/MYLK2/CNGA1/SLC25A5/CACNA1S/GTF2I/ATF6B/ATP2B3/AKT3/NFATC1/PPP1CA/ATP2A2/RAF1/CALM1/PPP1R12A/ITPR3/GNA11/ADRA2B/ROCK1/MAPK3/ATP2A3/ATP1B3/MEF2A/PPP1CB/ATP2B2/CALML4/ROCK2/NPR1/IRS2/MYH6/ADORA3/ATP2B1/NOS3/KCNMB3/RGS2/ATP2B4/PPIF/PPP1CC/AKT2/MRVI1/NPR2/CACNA1F/GNAI2/CALML5/ADCY6/GUCY1A2/PDE3A/PPP3CA/GNAI3/NFATC2/PLCB4/AKT1/SLC8A1/AGTR1/ITPR1/ADORA1/VDAC3/CALML3/PPP3CB/PIK3CG/ITPR2/ADCY9/IRS4/ADCY4/CREB3L4/CNGB1/IRS1/SLC25A6/SLC8A3/ATP1A1/MYL9/PPP3CC/MYLK3/CREB3L2/MYH7/PLCB3/KNG1/FXYD2/ADRB2/CREB5/INS/PIK3R6/CACNA1D/PDE3B/PDE2A/PLN/CREB3L1/INSR/CALM2/MYLK/PLCB1/ADRA2C/ADCY7/MEF2C/KCNMB1/GNA12/ATF2/CREB1/EDNRA/CALM3/MEF2D/PPP3R1/OPRD1/NPPC/KCNJ8/NFATC3/ATP1B1/PDE5A/EDNRB/GTF2IRD1/PRKG1/PRKCE/MYLK4/VDAC1/ADRA1B/ATP1A4/ADCY5/ATP1A2/ADRB1/ATP1A3/MAP2K1/ATP1B4/ADCY3/NPPB/KCNMB4/ADRB3/ADRA2A/GATA4/ADCY1/TRPC6/CREB3L3/ADCY2/KCNMA1/MEF2B/NFATC4/SLC8A2	161
KEGG	hsa04934	Cushing syndrome	150/6806	155/8135	1.93e-07	2.079e-06	7.602e-07	WNT2/FZD10/WNT9B/PDE8A/NCEH1/WNT3/FZD2/AIPL1/CREB3/GNAQ/WDR5B/ATF4/CAMK2G/CRHR1/CCND1/KCNK2/MAP2K2/PLCB2/ADCY8/CACNA1C/AIP/GNAI1/WNT7A/MAPK1/WNT8B/APC2/WNT16/CACNA1S/ARMC5/WNT7B/CRH/ATF6B/PRKACA/DVL2/FZD1/ITPR3/E2F1/MC2R/GNA11/WNT1/MAPK3/MEN1/WNT8A/CYP11A1/USP8/CDK2/FZD9/ORAI1/ASH2L/FH/STAR/RAP1B/CACNA1F/GNAI2/HSD3B2/CDKN1B/ADCY6/RAP1A/CDKN2C/CACNA1H/LDLR/GNAI3/GNAS/GSK3B/PDE11A/PLCB4/TCF7/RASD1/AGTR1/ITPR1/WNT10B/CAMK2A/CDKN2A/HSD3B1/CDK4/NR4A1/ITPR2/ADCY9/DVL3/ADCY4/CREB3L4/ARNT/KCNK3/CAMK2B/CDKN2B/CREB3L2/PLCB3/WNT4/PRKACB/RB1/POMC/PRKACG/CYP21A2/DVL1/CREB5/BRAF/CAMK2D/CACNA1D/CDK6/CTNNB1/E2F3/AHR/CREB3L1/PLCB1/WDR5/CDKN1A/ADCY7/AXIN1/ATF2/CREB1/CRHR2/SCARB1/CYP11B1/CCNE1/CYP17A1/CCNE2/CACNA1G/WNT5B/LEF1/FZD5/TCF7L2/WNT5A/FZD6/CACNA1I/APC/FZD7/FZD8/ADCY5/MAP2K1/AXIN2/SP1/FZD4/ADCY3/PBX1/TCF7L1/MRAP/ADCY1/CREB3L3/WNT11/EGFR/WNT2B/RBBP5/ADCY2/AGT/PDE8B/WNT9A/WNT10A/FZD3/WNT6/NR5A1	150
KEGG	hsa04810	Regulation of actin cytoskeleton	207/6806	218/8135	2.139e-07	2.232e-06	8.161e-07	FGF5/CHRM2/ITGA11/ARPC1A/ITGB2/FGF3/DIAPH1/VAV1/GNA13/ITGA5/IQGAP1/RAC1/CYFIP2/ACTG1/ITGA2/MAP2K2/CRKL/MYH9/RHOA/CFL1/ITGB4/NCKAP1L/PAK1/ARHGEF1/ARPC4/PAK2/ACTR2/F2R/ARPC1B/MAPK1/PIK3CB/ARAF/SPATA13/PFN1/MYLK2/FGD3/MSN/APC2/CHRM3/VCL/SSH1/ACTN1/PDGFRB/BCAR1/MYLPF/WASL/ITGAL/PIK3CD/ARPC2/SSH2/RRAS/FGF18/HRAS/LPAR4/PPP1CA/RAF1/EZR/PPP1R12A/RAC2/ARPC5/ITGA4/ROCK1/LIMK1/PIP4K2A/ARPC3/ITGAM/MAPK3/PXN/PIK3CA/FGF23/SLC9A1/ACTR3B/PPP1CB/ARPC5L/FGF7/ACTB/PIP5K1C/BAIAP2/ITGA2B/PIK3R2/ROCK2/CDC42/GSN/GIT1/CHRM4/PPP1R12C/FGF1/LPAR2/ACTN4/MYH11/ARHGEF6/PDGFD/FGF6/PFN4/ITGA9/PPP1CC/ITGAX/PIK3R1/MYL12A/MYL12B/LPAR1/PPP1R12B/SCIN/SOS1/PDGFC/RDX/FGFR4/VAV2/TMSB4Y/SOS2/NRAS/LIMK2/ITGA7/PIKFYVE/FGF16/ARHGEF7/FGFR2/ARHGEF4/ACTR3/MYL10/PDGFB/SSH3/CRK/GNG12/PIP5K1A/ITGA10/CYFIP1/ITGB7/IQGAP2/ITGB1/TIAM1/FGF17/MYL9/MYLK3/KRAS/KNG1/CXCR4/TMSB4X/PIP5K1B/PTK2/PAK4/ITGAE/BRAF/INS/FGF10/PFN2/CHRM5/WASF2/DIAPH2/CHRM1/LPAR5/EGF/MOS/ABI2/MYLK/ITGAD/FGF19/PIP4K2B/ITGAV/ITGB3/ITGA8/GNA12/FGF4/ITGB8/FGF2/FGF22/F2/SRC/FGF20/MYL7/FGD1/PAK3/FGF9/MYL5/PIK3R3/DOCK1/FN1/PIP4K2C/PDGFA/CFL2/MYL2/NCKAP1/RRAS2/MYLK4/FGFR1/ITGB5/BDKRB1/APC/PAK6/MYH10/CXCL12/MAP2K1/VAV3/DIAPH3/PDGFRA/FGF8/WASF1/INSRR/RAC3/ACTR3C/MRAS/ITGA3/FGFR3/MYH14/EGFR/ITGA6/ENAH	207
KEGG	hsa04630	JAK-STAT signaling pathway	156/6806	162/8135	3.637e-07	3.515e-06	1.285e-06	IL13RA2/IL2/IFNA2/IFNB1/CNTF/IFNA1/IFNA13/IL12A/GHR/IFNE/PTPN2/PTPN6/GRB2/AOX1/IL20/CCND1/IL2RG/IFNGR2/IL22RA1/STAT6/TYK2/PIK3CB/STAT5B/IL27RA/EPOR/JAK3/PDGFRB/IL12RB2/STAM/PIK3CD/AKT3/IL4R/IL6R/IL10RA/HRAS/STAT5A/RAF1/CSF3R/IFNAR1/EP300/IL2RA/MTOR/PIK3CA/IL20RA/PIAS3/JAK1/IL23A/PIK3R2/PIAS4/IL11RA/IL13RA1/SOCS5/IL4/IL10RB/IFNA8/AKT2/CCND3/CSF2RA/PIK3R1/IL6ST/IL12RB1/CSF2/SOS1/TSLP/JAK2/AKT1/SOS2/IL19/MYC/PDGFB/CSF2RB/STAT4/STAM2/CCND2/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/IL15/IRF9/IL12B/LEP/IL21R/IL3/IL10/IL3RA/PRLR/IFNG/CISH/OSM/LIFR/IFNGR1/IL9R/IL2RB/IL7R/SOCS4/MCL1/LIF/IL20RB/IL13/CRLF2/IL22/EGF/SOCS3/BCL2L1/CDKN1A/CSF3/IL21/FHL1/PIAS1/IL24/IFNA17/STAT3/GFAP/IL17D/IL5RA/THPO/STAT2/IL15RA/PIK3R3/OSMR/PIM1/IL9/PDGFA/CNTFR/BCL2/IFNW1/CTF1/STAT1/SOCS1/PTPN11/GH1/GH2/IL6/MPL/CREBBP/SOCS7/IL7/IL23R/IL22RA2/CSH1/PDGFRA/PRL/LEPR/CSH2/IFNK/EPO/EGFR/IFNAR2/IL11/SOCS2/SOCS6	156
KEGG	hsa04371	Apelin signaling pathway	135/6806	139/8135	3.683e-07	3.515e-06	1.285e-06	GNG13/RYR3/PIK3C3/PLAT/GNAQ/GNB1/CCND1/GNA13/GNG2/CALML6/MAP2K2/GNG5/PLCB2/GNB2/ADCY8/PIK3R5/GNAI1/BECN1/MAPK1/PIK3R4/MYLK2/APLN/TFAM/PRKACA/AKT3/RRAS/HRAS/MAP1LC3A/RAF1/MAP1LC3B/CALM1/RPS6KB2/PRKAB1/ITPR3/GNGT2/SMAD4/MTOR/HDAC5/MAPK3/MAP1LC3C/SLC9A1/MEF2A/SMAD3/CALML4/GNG3/PLIN1/GNG8/PRKAG2/GNG7/GNG10/NOS3/AKT2/GNAI2/CALML5/ADCY6/SMAD2/GNAI3/GNB3/PLCB4/AKT1/SLC8A1/NRAS/AGTR1/ITPR1/MAP1LC3B2/PRKAA1/GNG11/CALML3/GNG12/GNB5/PIK3CG/ITPR2/ADCY9/ADCY4/RPS6/SLC8A3/JAG1/UCP1/PRKAG1/ACTA2/MYLK3/KRAS/PLCB3/RPS6KB1/PRKACB/PRKACG/EGR1/SPP1/NRF1/PIK3R6/RYR1/SPHK2/MYL4/PDE3B/SERPINE1/KLF2/CALM2/MYLK/PLCB1/GNGT1/ADCY7/MEF2C/CALM3/MEF2D/TGFBR1/SPHK1/APLNR/HDAC4/GNB4/MYL2/PRKAG3/RRAS2/PRKCE/MYLK4/RYR2/PRKAB2/GNG4/ADCY5/CAMK4/CDH1/MAP2K1/NOTCH3/ADCY10/PRKAA2/NOS2/NOS1/MYL3/ADCY3/ADCY1/MRAS/ADCY2/LIPE/MEF2B/PPARGC1A/SLC8A2	135
KEGG	hsa05162	Measles	135/6806	139/8135	3.683e-07	3.515e-06	1.285e-06	IL2/IFNA2/IFNB1/IFNA1/IFNA13/IL12A/CD209/BAD/CASP9/NFKBIB/CCND1/IL2RG/CD46/CSNK2B/ADAR/IL1B/BAX/CASP3/EIF3H/TYK2/PIK3CB/STAT5B/BAK1/IRAK1/MSN/JAK3/IKBKG/MYD88/PIK3CD/AKT3/CSNK2A2/TBK1/STAT5A/FADD/TRAF3/MAVS/EIF2S1/IFNAR1/NFKBIA/IRAK4/IL2RA/RAB9A/MAP3K7/TNFAIP3/BID/IRF3/HSPA1L/CSNK2A1/PIK3CA/NFKB1/HSPA6/TRAF6/TLR9/JAK1/FAS/CDK2/PIK3R2/FOS/MAPK9/IKBKB/APAF1/HSPA8/HSPA1B/TRADD/IFNA8/TAB2/AKT2/CCND3/PIK3R1/CD3D/CASP8/CLEC4M/CDKN1B/RCHY1/GSK3B/JUN/AKT1/EIF2AK3/CD3G/EIF2AK1/BBC3/HSPA1A/CCND2/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/IFNA16/IRF9/IL12B/CHUK/IKBKE/CBLB/TLR2/TLR7/CYCS/IL2RB/FASLG/CDK6/TP53/MAPK8/BCL2L1/RELA/DDX58/IFNA17/STAT3/TLR4/CCNE1/FCGR2B/CD28/CCNE2/MAPK10/STAT2/PIK3R3/IFIH1/EIF2AK4/IRF7/BCL2/STAT1/SLAMF1/TP73/RAB9B/IL6/MX2/HSPA2/CD3E/EIF2AK2/MX1/IFNAR2/OAS1/IL1A	135
KEGG	hsa04014	Ras signaling pathway	219/6806	232/8135	4.365e-07	3.94e-06	1.44e-06	GNG13/FGF5/PLA2G2D/EFNA3/RASSF5/IGF1/FGF3/BAD/GRB2/GNB1/GNG2/RAC1/CALML6/MAP2K2/GNG5/RHOA/GNB2/PLA2G4D/PAK1/ABL2/BRAP/EFNA4/PRKCB/RAB5B/PAK2/MAPK1/RALGDS/PIK3CB/RASGRP2/ANGPT2/PDGFRB/VEGFC/IKBKG/NF1/KIT/PIK3CD/PRKACA/AKT3/RRAS/SHC1/FGF18/TBK1/HRAS/PLA2G6/RAF1/CALM1/RASSF1/SHC3/RAC2/CSF1R/RASAL3/RALB/GNGT2/PLD1/PLA2G4C/PLCG2/MAPK3/PIK3CA/STK4/PLD2/NFKB1/FGF23/JMJD7-PLA2G4B/PLA2G4B/FLT4/ETS2/FGF7/RIN1/CALML4/GNG3/PIK3R2/CDC42/MAPK9/IKBKB/FGF1/PDGFD/FGF6/GNG8/GNG7/GNG10/ELK1/IGF1R/PLA2G2A/RASA2/AKT2/PIK3R1/RAP1B/HTR7/RASA4B/PLA2G4F/CALML5/NTF3/RAP1A/NTRK1/SOS1/PDGFC/VEGFB/GNB3/KSR1/FGFR4/AKT1/SOS2/NRAS/HGF/FGF16/RASAL2/RASA4/FGFR2/GNG11/ABL1/SHOC2/PDGFB/GAB2/CALML3/GNG12/RAB5A/FLT3LG/RASGRP1/GNB5/ARF6/CHUK/VEGFA/TIAM1/LAT/FGF17/BDNF/SYNGAP1/TGFA/KRAS/RAB5C/RGL2/PRKACB/PRKACG/FASLG/ZAP70/GRIN2B/FOXO4/PAK4/RASA1/INS/FGF10/MAPK8/EXOC2/PGF/RALBP1/INSR/EGF/CALM2/PLA2G4A/BCL2L1/PRKCG/GNGT1/FLT1/FGF19/RELA/RALA/ANGPT4/RAPGEF5/RASGRP4/EFNA5/RASA3/PRKCA/NTF4/PLCG1/FGF4/EFNA1/GRIN2A/CALM3/KDR/ETS1/NTRK2/FGF2/FGF22/SHC4/GRIN1/PLA2G3/PLA2G12A/FLT3/RASGRF2/FGF20/MAPK10/PAK3/PLA1A/FGF9/EFNA2/PIK3R3/RASAL1/GNB4/PLA2G2F/PDGFA/RGL1/RRAS2/RASGRF1/PLA2G12B/PTPN11/FGFR1/PLA2G10/GNG4/PAK6/IGF2/MAP2K1/PLA2G1B/PLA2G2E/REL/CSF1/KSR2/PLCE1/PDGFRA/FGF8/RAC3/PLA2G5/NGFR/MRAS/FGFR3/SHC2/EGFR/GAB1/MET/RASGRP3	219
KEGG	hsa05171	Coronavirus disease - COVID-19	219/6806	232/8135	4.365e-07	3.94e-06	1.44e-06	IL2/IFNA2/IFNB1/MBL2/MMP3/MAS1/IFNA1/IFNA13/IL12A/F13B/C1R/C9/NFKBIB/RPL36AL/RPL19/RPL31/VWF/RPL32/RPL30/MAPK14/ADAR/IL1B/RPS2/RPL34/PRKCB/RPL38/TYK2/FGB/RPS21/RPL23A/MAPK1/RPL35A/PIK3CB/C6/ADAM17/RPL12/IRAK1/RPS23/RPL17/RPS17/RPL26/SYK/RPL24/FAU/RPS12/IKBKG/RPL28/MYD88/RPL37A/PIK3CD/IL6R/RPS24/TBK1/FCGR2A/RPLP0/RPS7/RPL41/RPL6/RPL7A/TRAF3/RPL29/RPL4/TNFRSF1A/MAVS/RPL3/TLR8/IFNAR1/NFKBIA/RPS15/RPL18/IRAK4/RPL21/MAP3K7/RPL36/IRF3/RPS13/RPL27A/RPL10/RPS19/RPL14/PLCG2/RPS15A/C2/RPL37/RPS27L/RPLP1/MAPK3/UBA52/PIK3CA/NFKB1/MAPK12/TRAF6/RPSA/RPL13A/C3/JAK1/RPL8/RPL7/RPS14/PIK3R2/RPS5/RPL35/C5AR1/RPL26L1/FOS/TNF/MAPK13/RPL13/MAPK9/IKBKB/RPS11/RPL15/RPS10/IFNA8/RPS27/RPLP2/TAB2/RPS8/RPS9/PIK3R1/IL6ST/CSF2/CYBB/C1QB/NLRP3/RPS28/JUN/C1QA/RPL5/RPS4X/RPL22/RPS18/AGTR1/HBEGF/RPS3/RPL36A/RPL39/RPS3A/CFD/SELP/RPL10L/CFB/RPS29/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/C3AR1/MAPK11/IRF9/IL12B/RPS6/CHUK/RPL11/RPL23/IKBKE/RPS16/TLR2/TLR7/RPL27/RPL10A/RPS20/RPS25/TMPRSS2/CASP1/F13A1/MAPK8/RPS26/PRKCG/CSF3/RELA/DDX58/RPL22L1/RPL9/C5/C1S/MASP2/PRKCA/PLCG1/IFNA17/STAT3/TLR4/F2/C8A/RPS27A/MAPK10/STAT2/RSL24D1/RPL18A/PIK3R3/MMP1/IFIH1/ACE2/RPL3L/STAT1/ACE/CCL2/IL6/FGA/C4A/C4B/MX2/MASP1/EIF2AK2/C8B/C1QC/ISG15/MX1/FGG/C8G/RPS4Y1/EGFR/IFNAR2/OAS1/C7	219
KEGG	hsa04925	Aldosterone synthesis and secretion	97/6806	98/8135	4.659e-07	4.095e-06	1.497e-06	CREB3/GNAQ/ATF4/CAMK2G/CALML6/NPPA/PLCB2/ADCY8/CACNA1C/PRKCB/CACNA1S/DAGLA/ATF6B/PRKACA/ATP2B3/CALM1/ITPR3/MC2R/GNA11/PRKD2/ATP1B3/CAMK1D/CYP11A1/ATP2B2/CALML4/NPR1/ORAI1/ATP2B1/KCNJ5/ATP2B4/CYP11B2/STAR/CACNA1F/HSD3B2/CALML5/ADCY6/CACNA1H/LDLR/GNAS/PLCB4/AGTR1/ITPR1/DAGLB/CAMK2A/HSD3B1/CALML3/NR4A1/ITPR2/ADCY9/ADCY4/CREB3L4/KCNK3/CAMK2B/ATP1A1/CREB3L2/PLCB3/PRKACB/POMC/PRKACG/CYP21A2/CREB5/CAMK1/CAMK2D/CACNA1D/PDE2A/CREB3L1/PRKD1/CALM2/PLCB1/PRKCG/KCNK9/ADCY7/ATF1/ATF2/PRKCA/CREB1/CALM3/SCARB1/CAMK1G/CACNA1G/NR4A2/ATP1B1/CACNA1I/PRKCE/PRKD3/ATP1A4/ADCY5/ATP1A2/CAMK4/ATP1A3/ATP1B4/ADCY3/ADCY1/CREB3L3/ADCY2/LIPE/AGT	97
KEGG	hsa05215	Prostate cancer	96/6806	97/8135	5.527e-07	4.733e-06	1.73e-06	MMP3/IGF1/PLAT/CREB3/BAD/CASP9/ATF4/GRB2/CCND1/HSP90B1/MAP2K2/MDM2/MAPK1/PIK3CB/ARAF/PDGFRB/IKBKG/PIK3CD/AKT3/HRAS/RAF1/E2F1/NFKBIA/EP300/SPINT1/MTOR/MAPK3/PIK3CA/NFKB1/PTEN/CDK2/PIK3R2/GSTP1/IKBKB/HSP90AB1/PDGFD/IGF1R/AKT2/FOXO1/PIK3R1/CDKN1B/SOS1/PDGFC/GSK3B/AKT1/TCF7/SOS2/NRAS/FGFR2/PDGFB/IL1R2/PLAU/CHUK/CREB3L4/ERBB2/MMP9/TGFA/KRAS/CREB3L2/RB1/KLK3/TMPRSS2/PDPK1/CREB5/BRAF/INS/CTNNB1/TP53/E2F3/CREB3L1/EGF/HSP90AA1/CDKN1A/SRD5A2/RELA/ETV5/ZEB1/CREB1/CCNE1/CCNE2/LEF1/PIK3R3/TCF7L2/AR/PDGFA/BCL2/ERG/FGFR1/CREBBP/MAP2K1/TCF7L1/PDGFRA/INSRR/CREB3L3/EGFR/NKX3-1	96
KEGG	hsa04015	Rap1 signaling pathway	199/6806	210/8135	6.101e-07	5.095e-06	1.863e-06	FGF5/EFNA3/RASSF5/IGF1/ADORA2A/ITGB2/FARP2/TLN1/GNAQ/FGF3/VAV1/RAC1/CALML6/LCP2/ACTG1/MAP2K2/CRKL/PARD6A/RHOA/PLCB2/MAPK14/ADCY8/RGS14/GNAI1/EFNA4/PRKCB/VASP/ADORA2B/SIPA1L1/F2R/MAPK1/RALGDS/PIK3CB/RASGRP2/ANGPT2/PFN1/PDGFRB/VEGFC/BCAR1/KIT/ITGAL/PIK3CD/AKT3/RRAS/FGF18/HRAS/LPAR4/EVL/RAF1/CALM1/ARAP3/RAC2/CSF1R/RALB/SIPA1/ITGAM/KRIT1/PRKD2/MAPK3/PIK3CA/FGF23/MAPK12/FLT4/FGF7/APBB1IP/ACTB/F2RL3/CALML4/ITGA2B/PIK3R2/CDC42/MAPK13/FGF1/LPAR2/PDGFD/FGF6/PFN4/IGF1R/PARD3/FPR1/AKT2/PIK3R1/RAP1B/LPAR1/GNAI2/CALML5/ADCY6/RAP1A/MAP2K6/PDGFC/VEGFB/GNAI3/GNAS/PRKCZ/PLCB4/FGFR4/AKT1/VAV2/NRAS/HGF/FGF16/GNAO1/THBS1/FGFR2/PDGFB/SIPA1L3/RAPGEF1/CRK/CALML3/MAPK11/ADCY9/ADCY4/VEGFA/TLN2/ITGB1/TIAM1/LAT/FGF17/MAGI1/KRAS/PLCB3/GRIN2B/BRAF/INS/FGF10/PFN2/PRKCI/CTNNB1/LPAR5/SIPA1L2/PGF/PRKD1/INSR/EGF/PARD6G/CALM2/PLCB1/SKAP1/PRKCG/FLT1/FGF19/RALA/ADCY7/ITGB3/ANGPT4/RAPGEF5/MAGI3/EFNA5/PRKCA/PLCG1/FGF4/EFNA1/GRIN2A/RAPGEF2/CALM3/KDR/FGF2/FGF22/GRIN1/SRC/FGF20/DOCK4/FGF9/EFNA2/PIK3R3/PDGFA/DRD2/RAPGEF3/RAP1GAP/MAP2K3/RAPGEF4/PRKD3/FGFR1/ADCY5/PARD6B/LPAR3/CDH1/MAP2K1/ADCY3/CSF1/VAV3/PLCE1/PDGFRA/MAGI2/FGF8/RAPGEF6/ID1/RAC3/ADCY1/NGFR/MRAS/CNR1/FGFR3/EGFR/CTNND1/MET/ENAH/ADCY2/RASGRP3	199
KEGG	hsa05224	Breast cancer	142/6806	147/8135	6.359e-07	5.18e-06	1.894e-06	FGF5/WNT2/FZD10/WNT9B/IGF1/PGR/WNT3/FZD2/FGF3/LRP5/GRB2/CCND1/MAP2K2/BAX/WNT7A/NCOA3/GADD45B/MAPK1/PIK3CB/WNT8B/NOTCH1/FRAT1/ARAF/BAK1/APC2/WNT16/WNT7B/KIT/PIK3CD/AKT3/SHC1/NCOA1/FGF18/DVL2/HRAS/RAF1/RPS6KB2/FZD1/E2F1/SHC3/WNT1/MTOR/MAPK3/PIK3CA/FGF23/WNT8A/PTEN/FLT4/FGF7/PIK3R2/NFKB2/FOS/FGF1/FGF6/FZD9/IGF1R/AKT2/PIK3R1/BRCA1/SOS1/GSK3B/JUN/AKT1/TCF7/SOS2/NRAS/FGF16/MYC/HES1/WNT10B/DDB2/POLK/CDK4/CSNK1A1/DVL3/FGF17/ERBB2/JAG1/KRAS/DLL1/JAG2/RPS6KB1/WNT4/RB1/DVL1/ESR2/BRAF/FGF10/CDK6/CTNNB1/TP53/E2F3/GADD45A/EGF/HEYL/HES5/CDKN1A/FGF19/DLL4/AXIN1/FGF4/NOTCH2/FGF2/FGF22/SHC4/ESR1/FGF20/DLL3/WNT5B/LEF1/FZD5/FGF9/GADD45G/PIK3R3/TCF7L2/WNT5A/BRCA2/FZD6/FGFR1/APC/FZD7/FZD8/MAP2K1/NOTCH3/FRAT2/AXIN2/SP1/FZD4/HEY1/NOTCH4/LRP6/TCF7L1/FGF8/WNT11/HEY2/SHC2/EGFR/WNT2B/WNT9A/WNT10A/FZD3/WNT6	142
KEGG	hsa04919	Thyroid hormone signaling pathway	118/6806	121/8135	9.112e-07	7.246e-06	2.649e-06	SLC16A2/SLCO1C1/DIO1/PLCD1/THRB/BAD/CASP9/CCND1/ACTG1/MAP2K2/HDAC2/PLCB2/MED12/PRKCB/MDM2/NCOA3/TSC2/MAPK1/HDAC1/PIK3CB/NOTCH1/RHEB/PIK3CD/RXRB/PRKACA/AKT3/NCOA1/HRAS/ATP2A2/RAF1/HDAC3/KAT2B/EP300/MED16/MTOR/PLCG2/MED24/MAPK3/PIK3CA/SLC9A1/ATP2A3/ATP1B3/ACTB/SIN3A/PIK3R2/RXRA/PFKP/MED14/PFKM/MYH6/AKT2/FOXO1/PIK3R1/MED12L/MED17/PLCD4/MED27/GSK3B/PLCB4/AKT1/MED13/NRAS/MYC/PLCZ1/MED30/PLCD3/NCOR1/ATP1A1/THRA/PFKFB2/KRAS/MYH7/PLCB3/WNT4/PRKACB/PRKACG/MED13L/MED1/FXYD2/MED4/RCAN1/HIF1A/PDPK1/PFKL/CTNNB1/NCOA2/TP53/PLN/PLCB1/PRKCG/ITGAV/ITGB3/SLC2A1/PRKCA/PLCG1/NOTCH2/SRC/ESR1/PIK3R3/ATP1B1/RXRG/STAT1/ATP1A4/CREBBP/ATP1A2/DIO3/ATP1A3/TBC1D4/MAP2K1/NOTCH3/ATP1B4/KAT2A/BMP4/PLCE1/NOTCH4/GATA4/SLC16A10/RCAN2	118
KEGG	hsa04931	Insulin resistance	106/6806	108/8135	9.337e-07	7.252e-06	2.651e-06	SLC2A2/GYS2/PPP1R3A/SLC27A4/PPARA/CREB3/PTPN1/PPP1R3D/PRKCB/PIK3CB/CPT1A/RPS6KA1/PIK3CD/AKT3/PPP1CA/TNFRSF1A/RPS6KB2/PRKAB1/NFKBIA/RPS6KA3/PCK1/MLX/GFPT2/MTOR/CRTC2/PRKCD/PIK3CA/PYGM/NFKB1/PTEN/PPP1CB/G6PC/PYGL/PIK3R2/TNF/MAPK9/IKBKB/IRS2/PRKAG2/NOS3/GYS1/PPP1CC/AKT2/FOXO1/PIK3R1/G6PC3/SLC27A5/CD36/GSK3B/PRKCZ/MLXIP/AKT1/PRKCQ/SLC27A3/PRKAA1/SLC27A2/G6PC2/PPP1R3B/SLC27A1/OGT/CREB3L4/IRS1/PCK2/NR1H2/SREBF1/PPP1R3C/PRKAG1/PYGB/CREB3L2/RPS6KB1/NR1H3/PPP1R3E/PDPK1/CREB5/INS/MAPK8/CREB3L1/INSR/PTPRF/SOCS3/GFPT1/RELA/SLC2A1/CREB1/STAT3/RPS6KA2/CPT1B/RPS6KA6/MAPK10/TRIB3/PIK3R3/PRKAG3/PRKCE/ACACB/PRKAB2/PTPN11/IL6/TBC1D4/PRKAA2/SLC27A6/PPARGC1B/CREB3L3/AGT/MLXIPL/SLC2A4/PPARGC1A	106
KEGG	hsa04142	Lysosome	128/6806	132/8135	1.071e-06	8.114e-06	2.967e-06	ATP6V1H/PPT2/ATP6V0D1/LAMP2/GALNS/AP3M1/GGA3/GUSB/HYAL1/SLC11A2/GNPTG/GALC/PSAP/HYAL3/GLB1/GBA/ATP6V0A1/ABCA2/MAN2B1/ATP6AP1/ENTPD4/DMXL1/CTSW/HEXB/AP1G2/AGA/GLA/CLTA/ARSG/MANBA/PLA2G15/CTSA/SORT1/NPC2/AP1B1/CD68/CLTC/CLTB/AP1G1/CTSH/HGSNAT/TCIRG1/ARSA/AP4B1/NAGLU/CD63/CTSC/CTSS/SMPD1/FUCA2/TPP1/HYAL4/NPC1/LGMN/ATP6V0B/HEXA/GAA/HYAL2/GNPTAB/IDUA/CTSF/NAGPA/PPT1/CD164/LIPA/CTSZ/ATP6V0A2/ACP5/M6PR/MFSD8/CLTCL1/SLC11A1/AP3D1/DNASE2B/LAPTM4B/AP3B1/AP3S1/WDR7/IDS/GM2A/NEU1/ATP6V0D2/ATP6V0C/AP1S1/CTSD/LAPTM5/GGA1/AP1M2/DNASE2/CTSB/CTNS/AP3M2/IGF2R/SGSH/MCOLN1/CTSK/LITAF/AP1M1/NAPSA/SPAM1/AP1S2/SUMF1/CLN3/LAPTM4A/NAGA/ACP2/FUCA1/AP4M1/CLN5/GNS/DMXL2/AP3S2/ABCB9/GGA2/NCOA7/CTSO/ASAH1/LAMP1/ATP6V0A4/AP4E1/AP1S3/SCARB2/AP4S1/SLC17A5/AP3B2/CTSG/PSAPL1/ARSB	128
KEGG	hsa04912	GnRH signaling pathway	92/6806	93/8135	1.093e-06	8.114e-06	2.967e-06	MMP14/GNAQ/ATF4/CAMK2G/GRB2/CALML6/MAP2K2/MAP3K3/PLCB2/MAPK14/ADCY8/CACNA1C/PLA2G4D/PRKCB/MAPK1/GNRH1/PTK2B/CACNA1S/MAPK7/PRKACA/HRAS/RAF1/CALM1/ITPR3/GNA11/PLD1/PLA2G4C/PRKCD/MAPK3/PLD2/MAPK12/JMJD7-PLA2G4B/PLA2G4B/MAP2K4/CALML4/CDC42/MAPK13/MAPK9/ELK1/PLA2G4F/CACNA1F/CALML5/ADCY6/MAP2K6/SOS1/LHB/GNAS/JUN/PLCB4/SOS2/NRAS/ITPR1/HBEGF/CAMK2A/CGA/CALML3/MAP3K4/MAPK11/ITPR2/ADCY9/ADCY4/CAMK2B/KRAS/PLCB3/PRKACB/PRKACG/EGR1/MAP3K2/CAMK2D/CACNA1D/MAP2K7/MAPK8/CALM2/PLCB1/PLA2G4A/ADCY7/MMP2/PRKCA/FSHB/CALM3/SRC/MAPK10/GNRHR/MAP2K3/MAP3K1/ADCY5/MAP2K1/ADCY3/GNRH2/ADCY1/EGFR/ADCY2	92
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	127/6806	131/8135	1.246e-06	8.835e-06	3.23e-06	IFNA2/IFNB1/IFNA1/IFNA13/HLA-E/ITGB2/PTPN6/GRB2/VAV1/RAC1/LCP2/PPP3R2/MAP2K2/IFNGR2/FYN/PAK1/CASP3/PRKCB/TYROBP/MAPK1/PIK3CB/ARAF/HCST/PTK2B/SYK/ITGAL/PIK3CD/SHC1/NFATC1/HRAS/RAF1/IFNAR1/SHC3/HLA-C/RAC2/BID/SH3BP2/PLCG2/MAPK3/PIK3CA/HLA-B/NCR1/HLA-A/FAS/PIK3R2/TNF/CD244/ICAM2/MICA/IFNA8/NCR2/PIK3R1/NCR3/CSF2/KIR3DL2/FCER1G/SOS1/PPP3CA/NFATC2/KIR2DL2/VAV2/SOS2/NRAS/ICAM1/GZMB/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/KIR2DS5/PPP3CB/KIR2DL1/IFNA16/RAET1E/KIR2DS2/KIR2DS4/LAT/TNFRSF10B/IFNG/CD48/LCK/PPP3CC/KRAS/PRF1/IFNGR1/ULBP1/KLRD1/CD247/FASLG/ZAP70/BRAF/KIR2DL3/KIR2DL5A/KIR2DS1/KIR2DS3/KLRK1/FCGR3B/FCGR3A/SH2D1A/KIR3DL3/PRKCG/TNFSF10/PRKCA/PLCG1/IFNA17/KLRC3/PPP3R1/SHC4/ULBP2/PIK3R3/TNFRSF10A/KIR3DL1/PTPN11/MICB/MAP2K1/VAV3/KLRC1/KLRC2/RAC3/SH2D1B/SHC2/IFNAR2/ULBP3	127
KEGG	hsa04722	Neurotrophin signaling pathway	116/6806	119/8135	1.247e-06	8.835e-06	3.23e-06	BAD/ATF4/CAMK2G/GRB2/NFKBIB/RAC1/CALML6/ARHGDIG/MAP2K5/MAP2K2/MAP3K3/CRKL/RHOA/KIDINS220/MAPK14/BAX/MAPK1/PIK3CB/IRAK1/ARHGDIB/MAPK7/ZNF274/RPS6KA1/PIK3CD/AKT3/SHC1/HRAS/SORT1/RIPK2/RAF1/CALM1/NFKBIA/SHC3/RPS6KA3/SH2B1/IRAK4/MATK/SH2B2/PLCG2/PRKCD/MAPK3/PIK3CA/NFKB1/PRDM4/MAPK12/TRAF6/ARHGDIA/NFKBIE/CALML4/PIK3R2/PSEN2/CDC42/MAPK13/MAPK9/IKBKB/MAPKAPK2/AKT2/YWHAE/SH2B3/PIK3R1/NTRK3/RAP1B/CALML5/NTF3/RAP1A/MAP3K5/NTRK1/MAGED1/SOS1/GSK3B/JUN/PSEN1/AKT1/SOS2/NRAS/ABL1/CAMK2A/RAPGEF1/CRK/CALML3/MAPK11/IRS1/CAMK2B/BDNF/KRAS/FASLG/PDPK1/BRAF/CAMK2D/MAP2K7/TP53/MAPK8/FRS2/IRAK3/CALM2/RELA/NTF4/PLCG1/RPS6KA2/CALM3/FOXO3/NTRK2/SHC4/RPS6KA6/MAPK10/PIK3R3/BCL2/RPS6KA5/TP73/PTPN11/MAP3K1/CAMK4/MAP2K1/NGFR/SHC2/GAB1	116
KEGG	hsa04658	Th1 and Th2 cell differentiation	91/6806	92/8135	1.296e-06	8.835e-06	3.23e-06	IL2/IL12A/NFKBIB/IL2RG/PPP3R2/IFNGR2/CD4/MAPK14/STAT6/TYK2/MAPK1/NOTCH1/STAT5B/JAK3/IL12RB2/IKBKG/IL4R/NFATC1/STAT5A/HLA-DRA/NFKBIA/MAML1/IL2RA/MAPK3/NFKB1/MAPK12/JAK1/NFKBIE/FOS/MAPK13/MAPK9/IKBKB/IL4/CD3D/IL12RB1/PPP3CA/NFATC2/JUN/JAK2/PRKCQ/HLA-DMA/CD3G/STAT4/RUNX3/MAML3/PPP3CB/RBPJ/MAPK11/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/CHUK/HLA-DMB/LAT/JAG1/IFNG/LCK/HLA-DRB3/HLA-DRB5/PPP3CC/DLL1/JAG2/IFNGR1/GATA3/IL2RB/CD247/ZAP70/HLA-DOA/MAPK8/IL13/TBX21/RELA/DLL4/PLCG1/HLA-DPA1/PPP3R1/NOTCH2/MAML2/DLL3/MAPK10/NFATC3/RBPJL/HLA-DPB1/STAT1/HLA-DOB/HLA-DQA1/HLA-DQA2/CD3E/NOTCH3/MAF	91
KEGG	hsa05222	Small cell lung cancer	91/6806	92/8135	1.296e-06	8.835e-06	3.23e-06	LAMB1/ZBTB17/CASP9/CCND1/ITGA2/TRAF4/CKS1B/BAX/CASP3/GADD45B/PIK3CB/BAK1/IKBKG/PIK3CD/RXRB/AKT3/PTGS2/LAMA2/TRAF3/E2F1/NFKBIA/PIK3CA/NFKB1/TRAF6/PTEN/CDK2/ITGA2B/PIK3R2/XIAP/RXRA/IKBKB/LAMA3/APAF1/MAX/TRAF2/AKT2/PIK3R1/SKP2/CDKN1B/AKT1/LAMA1/MYC/COL4A3/DDB2/POLK/LAMC3/CDK4/COL4A2/BIRC7/BIRC2/CHUK/ITGB1/CDKN2B/CYCS/RB1/COL4A5/COL4A6/PTK2/TRAF1/CDK6/LAMC1/TP53/E2F3/GADD45A/BCL2L1/CDKN1A/ITGAV/RELA/LAMA5/RARB/LAMB4/LAMB2/FHIT/CKS2/CCNE1/CCNE2/LAMC2/GADD45G/PIK3R3/FN1/TRAF5/BCL2/COL4A1/RXRG/LAMB3/BIRC3/NOS2/COL4A4/ITGA3/ITGA6/LAMA4	91
KEGG	hsa05170	Human immunodeficiency virus 1 infection	200/6806	212/8135	1.627e-06	1.087e-05	3.974e-06	IFNA2/GNG13/IFNB1/IFNA1/IFNA13/CCNB3/HLA-E/GNAQ/BAD/CASP9/GNB1/GNG2/RAC1/CALML6/PPP3R2/MAP2K2/CRKL/TNFRSF1B/GNG5/GNB2/CD4/MAPK14/CFL1/PAK1/BAX/GNAI1/CASP3/PRKCB/TAPBP/PAK2/MAPK1/PIK3CB/PTK2B/BAK1/IRAK1/AP1G2/IKBKG/MYD88/PIK3CD/AKT3/TBK1/NFATC1/HRAS/RNF7/FADD/RAF1/TNFRSF1A/CALM1/RPS6KB2/AP1B1/ITPR3/NFKBIA/HLA-C/RAC2/RIPK1/GNA11/TAP1/IRAK4/AP1G1/APOBEC3C/GNGT2/MAP3K7/LIMK1/BID/IRF3/MTOR/PLCG2/MAPK3/PXN/PIK3CA/NFKB1/HLA-B/MAPK12/BTRC/TRAF6/APOBEC3G/HLA-A/FAS/CALML4/GNG3/PIK3R2/FOS/TNF/MAPK13/MAPK9/IKBKB/GNG8/GNG7/GNG10/TRADD/SAMHD1/CDK1/TRAF2/APOBEC3F/ATM/IFNA8/TAB2/AKT2/PIK3R1/CD3D/CASP8/GNAI2/CALML5/B2M/DDB1/CUL4B/MAP2K6/FBXW11/PPP3CA/GNAI3/TAB1/AP1S1/NFATC2/JUN/GNB3/CUL1/AKT1/NRAS/LIMK2/ITPR1/GNAO1/AP1M2/GNG11/CD3G/CRK/CUL4A/CALML3/GNG12/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/PPP3CB/IFNA16/HLA-F/PDIA3/GNB5/MAPK11/ITPR2/CHUK/TAP2/CALR/PPP3CC/TLR2/KRAS/RPS6KB1/RBX1/ATR/CYCS/CXCR4/CUL5/AP1M1/CD247/FASLG/PTK2/PAK4/APOBEC3D/SKP1/AP1S2/MAP2K7/MAPK8/CALM2/BCL2L1/PRKCG/GNGT1/RELA/PRKCA/PLCG1/CDC25C/IFNA17/CALM3/PPP3R1/TLR4/MAPK10/PAK3/NFATC3/PIK3R3/GNB4/CFL2/TRAF5/BCL2/APOBEC3A/CCNB2/MAP2K3/GNG4/PAK6/CD3E/MAP2K1/BST2/AP1S3/RAC3/CCNB1/CCR5/CHEK1/TRIM5/NFATC4	200
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	144/6806	150/8135	2.04e-06	1.336e-05	4.884e-06	SCN4B/CACNB3/ADRA1D/CREB3/GNAQ/CACNB1/ATF4/PPP2CA/PPP2R5D/CAMK2G/PPP2R5C/PPP2R2D/CALML6/ADRA1A/PLCB2/MAPK14/ADCY8/CACNA1C/PPP2R2C/PIK3R5/GNAI1/CACNG1/MAPK1/CACNA1S/CACNA2D1/TNNC1/PPP2R2A/ATF6B/PRKACA/ATP2B3/AKT3/PPP1CA/ATP2A2/CALM1/PPP2R1A/CACNG8/KCNQ1/MAPK3/SLC9A1/ATP2A3/MAPK12/ATP1B3/CACNA2D4/PPP1CB/ATP2B2/CALML4/PPP2R5B/MAPK13/CREM/MYH6/ATP2B1/TNNT2/TPM4/ATP2B4/PPP1CC/PPP1R1A/CACNA2D2/AKT2/CACNA1F/GNAI2/CALML5/ADCY6/SCN1B/GNAI3/GNAS/PLCB4/AKT1/SLC8A1/AGTR1/TPM3/PPP2R3C/CAMK2A/CALML3/PPP2R5A/PIK3CG/MAPK11/ADCY9/PPP2R5E/CACNA2D3/ADCY4/CREB3L4/SLC8A3/CACNB2/CAMK2B/ATP1A1/PPP2R3A/TPM2/PPP2R2B/CREB3L2/MYH7/PLCB3/PRKACB/PPP2R3B/PRKACG/FXYD2/ADRB2/CREB5/PIK3R6/CAMK2D/CACNG3/CACNA1D/PPP2CB/MYL4/AGTR2/PLN/CREB3L1/CALM2/PLCB1/ACTC1/ADCY7/ATF2/PRKCA/CREB1/CACNG4/CALM3/SCN7A/ATP1B1/MYL2/CACNG5/BCL2/RAPGEF3/RPS6KA5/TPM1/RYR2/RAPGEF4/ADRA1B/ATP1A4/CACNG2/ADCY5/ATP1A2/ADRB1/ATP1A3/ATP1B4/MYL3/ADCY3/ADCY1/CREB3L3/CACNG6/SCN5A/ADCY2/AGT/TNNI3/KCNE1/SLC8A2	144
KEGG	hsa04727	GABAergic synapse	88/6806	89/8135	2.158e-06	1.36e-05	4.972e-06	GABRA6/SLC6A1/GNG13/GABRE/GABRA4/GABRR1/GABRA2/GABRG2/SLC32A1/GABRB1/GNB1/KCNJ6/GNG2/GNG5/SLC12A5/GNB2/ADCY8/CACNA1C/GNAI1/PRKCB/NSF/CACNA1S/PRKACA/GABARAPL2/GNGT2/GABRP/ABAT/GNG3/SLC6A11/GLS/GNG8/GABARAP/GNG7/GNG10/HAP1/GLUL/CACNA1F/GNAI2/ADCY6/GABBR1/GABARAPL1/GNAI3/GNB3/GNAO1/GABRA1/GNG11/GNG12/GNB5/ADCY9/ADCY4/PRKACB/PRKACG/PLCL1/SLC38A3/CACNA1D/GABRA3/PRKCG/GNGT1/SLC38A1/ADCY7/SLC38A2/GABRR2/GAD2/PRKCA/GABRG1/SRC/GABRG3/GPHN/GABRB3/GABBR2/GAD1/GABRD/GNB4/SLC6A12/GLS2/CACNA1B/GABRR3/GNG4/TRAK2/ADCY5/CACNA1A/GABRA5/SLC38A5/ADCY3/ADCY1/SLC6A13/GABRB2/ADCY2	88
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	88/6806	89/8135	2.158e-06	1.36e-05	4.972e-06	PTPN6/NFKBIB/PPP3R2/MAP2K2/MAP3K3/IFNGR2/CSNK2B/CD4/MAPK14/TICAM1/MAPK1/PIK3CB/IKBKG/MYD88/PIK3CD/AKT3/CSNK2A2/NFATC1/HRAS/RAF1/RPS6KB2/NFKBIA/MTOR/CSNK2A1/MAPK3/PIK3CA/NFKB1/MAPK12/TRAF6/PTEN/TLR9/JAK1/NFKBIE/PIK3R2/BATF3/FOS/MAPK13/IKBKB/PDCD1/AKT2/PIK3R1/CD3D/MAP2K6/PPP3CA/NFATC2/JUN/JAK2/ALK/AKT1/PRKCQ/NRAS/CD3G/EML4/RASGRP1/PPP3CB/BATF/TIRAP/MAPK11/CHUK/LAT/IFNG/LCK/PPP3CC/TLR2/KRAS/RPS6KB1/IFNGR1/CD247/ZAP70/HIF1A/EGF/RELA/PLCG1/STAT3/PPP3R1/TLR4/CD28/NFATC3/PIK3R3/STAT1/MAP2K3/PTPN11/TICAM2/CD3E/CD274/MAP2K1/BATF2/EGFR	88
KEGG	hsa05226	Gastric cancer	143/6806	149/8135	2.351e-06	1.454e-05	5.317e-06	FGF5/WNT2/FZD10/WNT9B/WNT3/FZD2/FGF3/LRP5/GRB2/CCND1/TGFB1/MAP2K2/TGFB2/BAX/WNT7A/GADD45B/MAPK1/PIK3CB/WNT8B/FRAT1/ARAF/BAK1/APC2/WNT16/WNT7B/PIK3CD/RXRB/AKT3/SHC1/FGF18/DVL2/HRAS/CTNNA1/RAF1/RPS6KB2/FZD1/E2F1/SHC3/CDH17/WNT1/SMAD4/MTOR/MAPK3/PIK3CA/FGF23/SHH/WNT8A/SMAD3/FGF7/CDK2/TERT/PIK3R2/RXRA/FGF1/FGF6/FZD9/MUC2/MLH1/CDX2/AKT2/TGFBR2/PIK3R1/CDKN1B/SMAD2/SOS1/GSK3B/ABCB1/AKT1/TCF7/SOS2/NRAS/HGF/FGF16/MYC/FGFR2/WNT10B/DDB2/POLK/CSNK1A1/DVL3/FGF17/ERBB2/CDKN2B/KRAS/RPS6KB1/WNT4/RB1/DVL1/BRAF/FGF10/CTNNB1/TP53/E2F3/GADD45A/EGF/CDKN1A/FGF19/RARB/CTNNA3/AXIN1/FGF4/FGF2/FGF22/SHC4/TGFBR1/CTNNA2/FGF20/CCNE1/CCNE2/WNT5B/LEF1/FZD5/FGF9/GADD45G/PIK3R3/TCF7L2/WNT5A/FZD6/BCL2/RXRG/APC/FZD7/FZD8/CDH1/MAP2K1/FRAT2/AXIN2/FZD4/LRP6/TCF7L1/TGFB3/FGF8/WNT11/REG4/SHC2/EGFR/WNT2B/GAB1/MET/WNT9A/WNT10A/FZD3/WNT6	143
KEGG	hsa04724	Glutamatergic synapse	111/6806	114/8135	2.72e-06	1.652e-05	6.038e-06	GNG13/SLC17A8/SLC17A7/GNAQ/GNB1/GRM6/GNG2/PPP3R2/GNG5/PLCB2/GNB2/ADCY8/CACNA1C/PLA2G4D/GNAI1/PRKCB/MAPK1/GRIA2/HOMER3/PRKACA/DLG4/ITPR3/GNGT2/PLD1/PLA2G4C/MAPK3/PLD2/JMJD7-PLA2G4B/PLA2G4B/GNG3/GLS/GNG8/GNG7/GNG10/GRIK5/GLUL/PLA2G4F/GNAI2/ADCY6/GRIK1/GRM3/PPP3CA/GNAI3/SHANK2/GNAS/GNB3/PLCB4/GRM4/GRM2/ITPR1/GNAO1/GNG11/GRIN2D/GNG12/PPP3CB/GNB5/ITPR2/SLC1A1/ADCY9/ADCY4/PPP3CC/PLCB3/PRKACB/PRKACG/GRIN2C/GRM8/GRIN2B/SLC38A3/CACNA1D/SHANK3/PLCB1/PLA2G4A/PRKCG/GNGT1/KCNJ3/SLC38A1/ADCY7/SLC1A7/SLC38A2/GRIN3B/SLC17A6/PRKCA/GRIN2A/PPP3R1/GRIN3A/GRIN1/GRIK3/SLC1A2/HOMER1/GNB4/GRIA1/GRIK2/GRIA4/GLS2/GNG4/GRIA3/SHANK1/ADCY5/CACNA1A/SLC1A6/GRIK4/SLC1A3/GRM7/GRM1/DLGAP1/ADCY3/TRPC1/ADCY1/HOMER2/ADCY2/GRM5	111
KEGG	hsa04916	Melanogenesis	99/6806	101/8135	2.908e-06	1.735e-05	6.342e-06	WNT2/FZD10/WNT9B/WNT3/FZD2/CREB3/GNAQ/CAMK2G/CALML6/MAP2K2/PLCB2/ADCY8/GNAI1/PRKCB/WNT7A/MAPK1/WNT8B/WNT16/WNT7B/KIT/PRKACA/DVL2/HRAS/RAF1/CALM1/FZD1/EP300/WNT1/MAPK3/MC1R/WNT8A/CALML4/FZD9/GNAI2/CALML5/ADCY6/GNAI3/GNAS/GSK3B/PLCB4/TCF7/NRAS/GNAO1/TYRP1/WNT10B/MITF/CAMK2A/CALML3/ADCY9/DVL3/ADCY4/CREB3L4/CAMK2B/KRAS/EDN1/CREB3L2/ASIP/PLCB3/WNT4/PRKACB/POMC/PRKACG/DVL1/CAMK2D/CTNNB1/CREB3L1/CALM2/PLCB1/PRKCG/ADCY7/PRKCA/CREB1/CALM3/WNT5B/LEF1/FZD5/TCF7L2/WNT5A/FZD6/DCT/EDNRB/CREBBP/FZD7/FZD8/ADCY5/MAP2K1/FZD4/ADCY3/TCF7L1/TYR/ADCY1/CREB3L3/WNT11/WNT2B/ADCY2/WNT9A/WNT10A/FZD3/WNT6	99
KEGG	hsa05225	Hepatocellular carcinoma	160/6806	168/8135	3.022e-06	1.771e-05	6.474e-06	WNT2/FZD10/WNT9B/WNT3/FZD2/BAD/LRP5/GRB2/CCND1/TGFB1/SMARCD1/ARID1A/ACTG1/MAP2K2/TGFB2/BAX/PRKCB/WNT7A/GADD45B/MAPK1/PIK3CB/WNT8B/FRAT1/ARAF/KEAP1/BAK1/APC2/WNT16/GSTA3/WNT7B/SMARCC1/NFE2L2/PIK3CD/AKT3/BRD7/SHC1/TXNRD1/DVL2/HRAS/GSTO1/RAF1/RPS6KB2/FZD1/E2F1/SHC3/WNT1/SMAD4/MTOR/PLCG2/DPF1/MAPK3/NQO1/PIK3CA/GSTT1/WNT8A/SMARCD3/PTEN/SMAD3/SMARCB1/ACTB/TERT/PIK3R2/GSTP1/SMARCA4/FZD9/ELK1/IGF1R/MGST3/AKT2/TGFBR2/PIK3R1/TXNRD2/PHF10/SMAD2/SMARCC2/SOS1/GSK3B/AKT1/TCF7/MGST1/SOS2/NRAS/HGF/ARID2/SMARCD2/MYC/WNT10B/DDB2/CDKN2A/POLK/CDK4/CSNK1A1/HMOX1/DVL3/SMARCA2/TGFA/KRAS/RPS6KB1/WNT4/RB1/DVL1/BRAF/GSTO2/CDK6/CTNNB1/TP53/E2F3/PBRM1/SMARCE1/GADD45A/GSTT2/GSTM4/BCL2L1/PRKCG/CDKN1A/GSTM3/AXIN1/PRKCA/PLCG1/SHC4/TGFBR1/GSTM1/WNT5B/LEF1/FZD5/GADD45G/PIK3R3/TCF7L2/ACTL6B/WNT5A/ARID1B/ACTL6A/FZD6/MGST2/GSTA4/GSTM5/APC/IGF2/GSTM2/FZD7/FZD8/MAP2K1/TXNRD3/FRAT2/AXIN2/FZD4/LRP6/TCF7L1/TGFB3/WNT11/SHC2/EGFR/WNT2B/GAB1/MET/WNT9A/WNT10A/FZD3/WNT6/DPF3	160
KEGG	hsa04725	Cholinergic synapse	110/6806	113/8135	3.177e-06	1.808e-05	6.609e-06	GNG13/SLC5A7/CHRM2/CHRNB4/CREB3/GNAQ/ATF4/CAMK2G/GNB1/KCNJ6/GNG2/FYN/GNG5/PLCB2/GNB2/ADCY8/CACNA1C/PIK3R5/GNAI1/PRKCB/CHRNA4/MAPK1/PIK3CB/CHRNA3/CHRM3/CACNA1S/PIK3CD/PRKACA/AKT3/HRAS/ITPR3/GNA11/KCNJ12/GNGT2/KCNQ1/MAPK3/PIK3CA/GNG3/PIK3R2/FOS/CHRM4/GNG8/GNG7/GNG10/KCNQ4/CHRNB2/AKT2/PIK3R1/CACNA1F/GNAI2/ADCY6/KCNJ4/GNAI3/JAK2/GNB3/PLCB4/AKT1/CHRNA7/NRAS/ITPR1/GNAO1/GNG11/CAMK2A/GNG12/GNB5/PIK3CG/ITPR2/ADCY9/ADCY4/CREB3L4/CAMK2B/KRAS/CREB3L2/PLCB3/PRKACB/PRKACG/CREB5/PIK3R6/CAMK2D/CACNA1D/CHRM5/CHRM1/CREB3L1/PLCB1/PRKCG/GNGT1/KCNJ3/ADCY7/PRKCA/CREB1/KCNJ2/KCNQ2/CHRNA6/PIK3R3/GNB4/BCL2/CACNA1B/GNG4/ADCY5/CACNA1A/CAMK4/MAP2K1/SLC18A3/ADCY3/ADCY1/CREB3L3/KCNQ3/ADCY2/CHAT/ACHE	110
KEGG	hsa04210	Apoptosis	131/6806	136/8135	3.194e-06	1.808e-05	6.609e-06	PARP3/TUBA1C/BAD/CASP9/ATF4/BCL2L11/ACTG1/MAP2K2/TUBA1B/BAX/CASP3/ENDOG/TUBA1A/GADD45B/DAXX/MAPK1/HTRA2/PIK3CB/BAK1/CFLAR/TUBA4A/CTSW/BCL2A1/IKBKG/PIK3CD/AKT3/HRAS/FADD/RAF1/TNFRSF1A/EIF2S1/ITPR3/LMNB2/NFKBIA/RIPK1/PARP4/CTSH/BID/CTSC/MAPK3/PIK3CA/CTSS/NFKB1/TUBA3D/TUBA3E/TUBAL3/ACTB/FAS/CASP6/PIK3R2/CTSF/XIAP/AIFM1/DDIT3/CTSZ/FOS/TNF/MAPK9/IKBKB/APAF1/PARP1/TRADD/SPTAN1/TRAF2/ATM/DFFA/AKT2/PIK3R1/CASP8/TUBA3C/MAP3K5/NTRK1/JUN/CTSD/TUBA8/AKT1/NRAS/LMNB1/ITPR1/EIF2AK3/CTSB/CASP12/CSF2RB/BBC3/GZMB/ITPR2/TP53AIP1/BIRC2/CHUK/IL3/CASP2/TNFRSF10B/CASP10/IL3RA/PTPN13/CTSK/MAP3K14/KRAS/PRF1/CYCS/CAPN2/FASLG/MCL1/LMNA/PDPK1/TRAF1/TP53/MAPK8/GADD45A/DFFB/BCL2L1/RELA/TNFSF10/PARP2/CASP7/MAPK10/GADD45G/PIK3R3/DAB2IP/DIABLO/BCL2/TNFRSF10A/CTSO/PMAIP1/BIRC3/MAP2K1/SPTA1/HRK/BIRC5/CAPN1/ERN1	131
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	98/6806	100/8135	3.418e-06	1.903e-05	6.956e-06	NOX1/PLCD1/DIAPH1/CCND1/TGFB1/RAC1/TGFB2/PLCB2/MAPK14/IL1B/BAX/CASP3/PRKCB/MAPK1/PIK3CB/STAT5B/VEGFC/PIK3CD/AKT3/NFATC1/HRAS/STAT5A/SMAD4/PLCG2/PRKCD/MAPK3/PIK3CA/NFKB1/MAPK12/SMAD3/PIK3R2/CDC42/TNF/MAPK13/MAPK9/NOS3/AKT2/TGFBR2/FOXO1/AGER/PIK3R1/CDKN1B/SMAD2/CYBB/PLCD4/VEGFB/JUN/JAK2/F3/PRKCZ/PLCB4/AKT1/SELE/NRAS/AGTR1/ICAM1/COL4A3/CDK4/PLCD3/COL4A2/MAPK11/NOX4/VEGFA/THBD/KRAS/EDN1/PLCB3/COL4A5/COL4A6/EGR1/MAPK8/SERPINE1/PLCB1/RELA/COL1A1/MMP2/PRKCA/PLCG1/STAT3/TGFBR1/MAPK10/PIK3R3/VCAM1/FN1/PIM1/BCL2/COL4A1/STAT1/CCL2/PRKCE/IL6/PLCE1/TGFB3/COL4A4/COL3A1/AGT/COL1A2/IL1A	98
KEGG	hsa05210	Colorectal cancer	85/6806	86/8135	3.589e-06	1.965e-05	7.184e-06	BAD/CASP9/BCL2L11/GRB2/DCC/CCND1/TGFB1/RAC1/MSH3/MAP2K2/TGFB2/RHOA/BAX/CASP3/GADD45B/MAPK1/RALGDS/PIK3CB/ARAF/BAK1/APC2/PIK3CD/AKT3/MSH6/HRAS/RAF1/RPS6KB2/RAC2/RALB/SMAD4/MTOR/MAPK3/PIK3CA/SMAD3/PIK3R2/FOS/MAPK9/MLH1/AKT2/TGFBR2/PIK3R1/SMAD2/SOS1/GSK3B/JUN/MSH2/AKT1/TCF7/SOS2/NRAS/MYC/DDB2/BBC3/POLK/TGFA/KRAS/RPS6KB1/CYCS/BRAF/CTNNB1/TP53/MAPK8/GADD45A/EGF/APPL1/CDKN1A/RALA/AXIN1/TGFBR1/MAPK10/LEF1/GADD45G/PIK3R3/TCF7L2/BCL2/APC/EREG/PMAIP1/MAP2K1/AXIN2/TCF7L1/TGFB3/RAC3/EGFR/BIRC5	85
KEGG	hsa04668	TNF signaling pathway	109/6806	112/8135	3.709e-06	1.998e-05	7.305e-06	IFNB1/MMP3/IRF1/MMP14/CREB3/ATF4/JUNB/TNFRSF1B/MAPK14/PGAM5/IL1B/CASP3/MLKL/MAPK1/PIK3CB/CFLAR/BCL3/VEGFC/IKBKG/ATF6B/PIK3CD/AKT3/PTGS2/RIPK3/FADD/TRAF3/TNFRSF1A/NFKBIA/RIPK1/MAP3K7/TNFAIP3/CEBPB/MAPK3/PIK3CA/NFKB1/MAPK12/MAP2K4/FAS/PIK3R2/RPS6KA4/FOS/TNF/MAPK13/MAPK9/IKBKB/TRADD/TRAF2/NOD2/TAB2/AKT2/PIK3R1/CASP8/CSF2/MAP3K5/MAP2K6/TAB1/CXCL1/JUN/AKT1/SELE/CCL5/ICAM1/IL15/DNM1L/MAPK11/BIRC2/CHUK/CREB3L4/ITCH/CXCL3/CASP10/JAG1/TAB3/MMP9/MAP3K14/EDN1/CREB3L2/LTA/MAP3K8/CREB5/TRAF1/LIF/MAP2K7/MAPK8/CREB3L1/SOCS3/RELA/ATF2/CREB1/CASP7/CCL20/MAPK10/CXCL6/BAG4/PIK3R3/DAB2IP/VCAM1/TRAF5/IL18R1/CCL2/RPS6KA5/MAP2K3/IL6/BIRC3/MAP2K1/CSF1/CXCL5/CREB3L3/CXCL2	109
KEGG	hsa04270	Vascular smooth muscle contraction	129/6806	134/8135	4.268e-06	2.263e-05	8.271e-06	KCNMB2/KCNU1/PLA2G2D/ADORA2A/ADRA1D/GNAQ/GNA13/RAMP1/CALML6/ADRA1A/MAP2K2/MYH9/NPPA/RHOA/PLCB2/ADCY8/CACNA1C/PLA2G4D/MYL6B/ARHGEF1/PRKCB/ADM/ADORA2B/MYL6/MAPK1/ACTG2/ARAF/MYLK2/RAMP2/CACNA1S/PRKACA/PPP1CA/PLA2G6/RAF1/CALM1/PPP1R12A/ITPR3/GNA11/ROCK1/PLA2G4C/PRKCD/MAPK3/ADM2/JMJD7-PLA2G4B/PLA2G4B/PPP1CB/PRKCH/CALCA/CALML4/ROCK2/NPR1/PPP1R12C/MYH11/KCNMB3/PLA2G2A/PPP1CC/CALD1/MRVI1/PLA2G4F/NPR2/CACNA1F/CALML5/ADCY6/PPP1R12B/GUCY1A2/ARHGEF11/PPP1R14A/GNAS/PLCB4/PRKCQ/AGTR1/ITPR1/CALCB/RAMP3/CALML3/ITPR2/ADCY9/ADCY4/MYL9/ACTA2/MYLK3/EDN1/PLCB3/PRKACB/PRKACG/AVP/BRAF/CACNA1D/CALM2/MYLK/PLCB1/PLA2G4A/PRKCG/ADCY7/AVPR1A/KCNMB1/CALCRL/GNA12/PRKCA/PTGIR/EDNRA/CALM3/PLA2G3/PLA2G12A/NPPC/PLA2G2F/PRKG1/PRKCE/MYLK4/PLA2G12B/PLA2G10/ADRA1B/EDN2/MYH10/ADCY5/MAP2K1/PLA2G1B/PLA2G2E/ADCY3/NPPB/EDN3/KCNMB4/AVPR1B/ADCY1/PLA2G5/MYH14/ADCY2/AGT/KCNMA1	129
KEGG	hsa04621	NOD-like receptor signaling pathway	174/6806	184/8135	4.961e-06	2.589e-05	9.464e-06	IFNA2/IFNB1/IFNA1/IFNA13/BRCC3/NFKBIB/PSTPIP1/CARD9/NLRC4/RHOA/PLCB2/MAPK14/TICAM1/IL1B/ANTXR1/VDAC2/TYK2/ATG5/MAPK1/TXN/TANK/GSDMD/IKBKG/MYD88/GABARAPL2/TBK1/ANTXR2/TRPM2/NLRP12/RIPK2/MAP1LC3A/RIPK3/FADD/TRAF3/NLRP1/MAP1LC3B/MAVS/ITPR3/IFNAR1/NFKBIA/RIPK1/IRAK4/PYCARD/DEFB103A/DEFB103B/MAP3K7/TNFAIP3/IRF3/TXNIP/PRKCD/MAPK3/MAP1LC3C/CASP4/CASR/NFKB1/TRPV2/GBP2/MAPK12/RBCK1/TRIP6/CARD16/TRAF6/JAK1/ATG12/P2RX7/SUGT1/XIAP/TNF/MAPK13/CARD8/MAPK9/IKBKB/HSP90AB1/NOD1/GABARAP/PKN2/TRAF2/NOD2/CYBA/IFNA8/TAB2/YWHAE/PANX1/CASP8/NLRP7/NLRX1/GABARAPL1/CYBB/MFN2/CARD6/NLRP3/NAIP/TAB1/CXCL1/JUN/CAMP/PLCB4/CCL5/ITPR1/MAP1LC3B2/TP53BP1/CTSB/CASP12/TXN2/VDAC3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/RNF31/NEK7/IFNA16/DNM1L/MAPK11/IRF9/ITPR2/ATG16L1/GBP5/BIRC2/CHUK/NLRP6/GPRC6A/PKN1/CXCL3/IKBKE/TAB3/PYDC1/NAMPT/AIM2/PLCB3/IFI16/CASP1/RNASEL/MAPK8/HSP90AA1/DEFA5/PLCB1/BCL2L1/RELA/CASP5/SHARPIN/IL18/IFNA17/TLR4/MAPK10/DEFA1/DEFA1B/DEFA3/TRPM7/STAT2/DHX33/MEFV/GBP3/TRAF5/IRF7/BCL2/STAT1/DEFB4A/CCL2/VDAC1/CARD18/DEFA6/IL6/GBP4/DEFA4/BIRC3/MFN1/GBP1/IFNAR2/CXCL2/OAS1	174
KEGG	hsa04921	Oxytocin signaling pathway	147/6806	154/8135	5.054e-06	2.597e-05	9.495e-06	RYR3/CACNB3/GNAQ/CACNB1/CAMK2G/CCND1/KCNJ6/CALML6/MAP2K5/ACTG1/PPP3R2/MAP2K2/NPPA/RHOA/PLCB2/ADCY8/CACNA1C/PLA2G4D/OXTR/EEF2/PIK3R5/MYL6B/GNAI1/PRKCB/CACNG1/MYL6/MAPK1/MYLK2/CACNA1S/CACNA2D1/MAPK7/PRKACA/PTGS2/NFATC1/HRAS/TRPM2/PPP1CA/RAF1/CALM1/PPP1R12A/PRKAB1/ITPR3/KCNJ12/CACNG8/ROCK1/PLA2G4C/MAPK3/JMJD7-PLA2G4B/PLA2G4B/CACNA2D4/CAMK1D/PPP1CB/ACTB/CALML4/ROCK2/FOS/NPR1/PPP1R12C/PRKAG2/KCNJ5/NOS3/ELK1/RGS2/PPP1CC/CACNA2D2/PLA2G4F/NPR2/CACNA1F/GNAI2/CALML5/ADCY6/PPP1R12B/KCNJ4/GUCY1A2/PPP3CA/GNAI3/GNAS/NFATC2/JUN/PLCB4/NRAS/ITPR1/GNAO1/PRKAA1/CAMK2A/CALML3/PPP3CB/PIK3CG/ITPR2/ADCY9/CACNA2D3/ADCY4/CACNB2/CAMK2B/MYL9/PRKAG1/PPP3CC/MYLK3/KRAS/PLCB3/PRKACB/PRKACG/RCAN1/CAMK1/PIK3R6/RYR1/CAMK2D/CACNG3/CACNA1D/CALM2/MYLK/PLCB1/PLA2G4A/PRKCG/CDKN1A/KCNJ3/CAMKK2/ADCY7/MEF2C/PRKCA/CACNG4/CALM3/PPP3R1/KCNJ2/CAMK1G/SRC/CD38/NFATC3/CACNG5/PRKAG3/MYLK4/RYR2/PRKAB2/CACNG2/ADCY5/CAMK4/MAP2K1/PRKAA2/ADCY3/OXT/ADCY1/CACNG6/EGFR/ADCY2/EEF2K/KCNJ9/NFATC4	147
KEGG	hsa04720	Long-term potentiation	67/6806	67/8135	6.118e-06	3.096e-05	1.132e-05	GNAQ/ATF4/CAMK2G/CALML6/PPP3R2/MAP2K2/PLCB2/ADCY8/CACNA1C/PRKCB/MAPK1/ARAF/GRIA2/RPS6KA1/PRKACA/HRAS/PPP1CA/RAF1/CALM1/ITPR3/EP300/RPS6KA3/MAPK3/PPP1CB/CALML4/PPP1CC/PPP1R1A/RAP1B/CALML5/RAP1A/PPP3CA/PLCB4/NRAS/ITPR1/CAMK2A/GRIN2D/CALML3/PPP3CB/ITPR2/CAMK2B/PPP3CC/KRAS/PLCB3/PRKACB/PRKACG/GRIN2C/GRIN2B/BRAF/CAMK2D/CALM2/PLCB1/PRKCG/PRKCA/GRIN2A/RPS6KA2/CALM3/PPP3R1/GRIN1/RPS6KA6/GRIA1/RAPGEF3/CREBBP/CAMK4/MAP2K1/GRM1/ADCY1/GRM5	67
KEGG	hsa04145	Phagosome	145/6806	152/8135	6.639e-06	3.309e-05	1.21e-05	MBL2/VAMP3/ATP6V1H/HLA-E/PIK3C3/ATP6V0D1/TUBA1C/CD209/ITGB2/C1R/LAMP2/ITGA5/RAC1/ACTG1/THBS4/ITGA2/TUBA1B/NCF4/CORO1A/ATP6V1E2/RAB5B/TUBA1A/SFTPA1/CD14/ATP6V0A1/ATP6AP1/NCF1/DYNC1H1/TUBA4A/ATP6V1F/DYNC1LI1/FCGR2A/ATP6V1E1/MRC2/NCF2/HLA-DRA/HLA-C/TAP1/ATP6V1G1/TCIRG1/ITGAM/CTSS/HLA-B/SEC61B/HGS/TUBA3D/TUBA3E/TUBAL3/ATP6V0B/TUBB1/ATP6V1B2/ACTB/C3/SEC61A1/HLA-A/ATP6V1B1/ATP6V0A2/M6PR/THBS3/DYNC1LI2/ATP6V1A/ATP6V0E2/SEC61A2/CYBA/TUBB/CLEC4M/MARCO/TUBA3C/ATP6V0D2/SEC61G/CD36/FCGR2C/CYBB/ATP6V1D/ATP6V0C/ATP6V1C1/STX18/TUBA8/ATP6V0E1/ATP6V1G3/HLA-DMA/PIKFYVE/SFTPD/EEA1/THBS1/SEC22B/HLA-G/RAB5A/FCAR/HLA-F/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/ITGB1/TAP2/CLEC7A/CALR/TUBB6/HLA-DRB3/HLA-DRB5/TLR2/RAB5C/COMP/STX7/TLR6/FCGR1A/HLA-DOA/FCGR3B/TFRC/TUBB3/FCGR3A/PLA2R1/CANX/ITGAV/DYNC1I2/ITGB3/RILP/COLEC11/THBS2/HLA-DPA1/TLR4/SCARB1/STX12/RAB7B/FCGR2B/ATP6V1G2/MPO/HLA-DPB1/SFTPA2/RAB7A/DYNC1I1/HLA-DOB/ITGB5/HLA-DQA1/HLA-DQA2/LAMP1/ATP6V0A4/COLEC12/MSR1/NOS1/DYNC2H1/TUBB2B/OLR1/ATP6V1C2	145
KEGG	hsa04141	Protein processing in endoplasmic reticulum	162/6806	171/8135	7.564e-06	3.715e-05	1.358e-05	UBQLN3/ATXN3L/SYVN1/UBXN1/HSPA5/ATF4/SEC24C/SEC13/LMAN1L/HSP90B1/RNF185/UBE4B/PPP1R15A/VCP/DNAJB12/UBE2G1/LMAN2/BAX/DNAJC3/DNAJB1/HERPUD1/UBXN4/BCAP31/PDIA6/NPLOC4/DNAJC5G/DERL2/UBE2J1/AMFR/PREB/BAK1/PRKCSH/DNAJC5/DNAJA1/XBP1/GANAB/UBE2J2/NFE2L2/ATF6B/HYOU1/RPN2/OS9/FBXO2/EDEM1/MBTPS1/STUB1/UBQLN1/EIF2S1/SSR2/NGLY1/UGGT2/DNAJC10/SEC24B/DNAJB11/P4HB/SEC31A/EDEM2/HSPA1L/TUSC3/UBE2D2/SEC23B/DAD1/PLAA/HSPA6/SEC61B/SEC61A1/RAD23B/TRAM1L1/EDEM3/DDIT3/MAPK9/HSPA8/HSP90AB1/SEC31B/STT3B/HSPA1B/UBQLN2/SIL1/NSFL1C/TRAF2/MAN1A1/SEC61A2/HSPA4L/MAN1B1/RPN1/SSR3/PDIA4/MOGS/SEL1L/HSPBP1/SSR4/MAP3K5/SEC61G/UBE2D1/UBXN2A/CKAP4/RRBP1/CUL1/SEC24D/HSPH1/ATF6/UBE2D3/EIF2AK3/CASP12/UBXN6/EIF2AK1/TRAM1/HSPA1A/UGGT1/DNAJC1/PDIA3/SEC62/SEC23A/ERLEC1/BAG1/CALR/DERL1/STT3A/RAD23A/ATXN3/SAR1A/RBX1/SVIP/CAPN2/SEC63/DDOST/SKP1/MAP2K7/MAPK8/YOD1/ERP29/CANX/HSP90AA1/UBE2D4/DNAJB2/UBQLN4/SEL1L2/DNAJA2/SAR1B/SSR1/MAPK10/RNF5/MAN1C1/CRYAB/EIF2AK4/DERL3/BCL2/SEC24A/TXNDC5/CRYAA/HSPA2/UBXN8/BAG2/EIF2AK2/DNAJC5B/FBXO6/WFS1/LMAN1/CAPN1/ERN1/UBE2G2/MAN1A2	162
KEGG	hsa04915	Estrogen signaling pathway	132/6806	138/8135	1.1e-05	5.323e-05	1.946e-05	KRT13/KRT12/KRT20/KRT27/PGR/CREB3/GNAQ/ATF4/GRB2/KCNJ6/CALML6/HSP90B1/MAP2K2/PLCB2/ADCY8/GNAI1/NCOA3/MAPK1/PIK3CB/KRT34/KRT32/KRT33B/ATF6B/PIK3CD/PRKACA/AKT3/SHC1/NCOA1/KRT24/HRAS/RAF1/CALM1/ITPR3/SHC3/HSPA1L/PRKCD/MAPK3/PIK3CA/KRT19/HSPA6/RARA/CALML4/PIK3R2/FOS/HSPA8/HSP90AB1/KCNJ5/HSPA1B/NOS3/AKT2/PIK3R1/GNAI2/CALML5/ADCY6/GABBR1/SOS1/KRT38/GNAI3/GNAS/JUN/CTSD/KRT25/PLCB4/AKT1/KRT23/SOS2/NRAS/ITPR1/HBEGF/GNAO1/FKBP4/HSPA1A/KRT36/CALML3/ITPR2/ADCY9/ADCY4/CREB3L4/MMP9/TGFA/KRAS/CREB3L2/PLCB3/KRT18/PRKACB/POMC/PRKACG/ESR2/FKBP5/KRT35/CREB5/NCOA2/EBAG9/CREB3L1/HSP90AA1/CALM2/PLCB1/KCNJ3/ADCY7/MMP2/ATF2/CREB1/CALM3/KRT40/SHC4/KRT15/SRC/ESR1/GABBR2/PIK3R3/KRT14/KRT16/BCL2/KRT37/OPRM1/HSPA2/KRT9/ADCY5/MAP2K1/GRM1/SP1/ADCY3/KRT31/ADCY1/CREB3L3/TFF1/SHC2/EGFR/KRT10/ADCY2/KCNJ9/KRT17	132
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	78/6806	79/8135	1.17e-05	5.582e-05	2.041e-05	IGF1/BAD/BCL2L11/GRB2/MAP2K2/EIF4E2/BAX/PRKCB/MAPK1/PIK3CB/ARAF/PDGFRB/NF1/PIK3CD/AKT3/SHC1/IL6R/HRAS/RAF1/RPS6KB2/EIF4EBP1/SHC3/MTOR/PLCG2/MAPK3/PIK3CA/PTEN/JAK1/PIK3R2/PDGFD/IGF1R/AKT2/PIK3R1/SOS1/PDGFC/GSK3B/JAK2/AKT1/SOS2/NRAS/HGF/GAS6/FGFR2/PDGFB/RPS6/VEGFA/NRG1/ERBB2/TGFA/KRAS/RPS6KB1/BRAF/EGF/BCL2L1/PRKCG/EIF4E/PRKCA/PLCG1/STAT3/KDR/FOXO3/FGF2/SHC4/SRC/PIK3R3/PDGFA/BCL2/IL6/MAP2K1/ERBB3/AXL/NRG2/PDGFRA/FGFR3/SHC2/EGFR/GAB1/MET	78
KEGG	hsa05135	Yersinia infection	131/6806	137/8135	1.263e-05	5.814e-05	2.125e-05	IL2/IFNB1/ARPC1A/GNAQ/VAV1/ITGA5/RAC1/LCP2/ACTG1/MAP2K2/GIT2/CRKL/NLRC4/RHOA/CD4/MAPK14/TICAM1/IL1B/ARHGEF1/ARPC4/ACTR2/ARPC1B/MAPK1/PIK3CB/PTK2B/ELMO1/IRAK1/ELMO2/WIPF3/IKBKG/RPS6KA1/BCAR1/MYD88/WASL/PIK3CD/ARPC2/AKT3/TBK1/FCGR2A/WAS/NFATC1/NFKBIA/RPS6KA3/WIPF1/RAC2/ARPC5/IRAK4/ITGA4/PYCARD/ROCK1/MAP3K7/LIMK1/IRF3/ARPC3/MAPK3/PXN/PIK3CA/NFKB1/MAPK12/RHOG/ACTR3B/TRAF6/ARPC5L/MAP2K4/ACTB/PIP5K1C/BAIAP2/PIK3R2/ROCK2/CDC42/FOS/TNF/MAPK13/MAPK9/IKBKB/PKN2/TRAF2/TAB2/AKT2/PIK3R1/MAP2K6/NLRP3/GSK3B/TAB1/NFATC2/JUN/AKT1/VAV2/SKAP2/ARHGEF7/ACTR3/CRK/PIP5K1A/MAPK11/ARF6/CHUK/ITGB1/PKN1/LAT/IL10/LCK/PIP5K1B/ZAP70/PTK2/CASP1/WASF2/MAP2K7/MAPK8/RELA/IL18/PLCG1/RPS6KA2/WIPF2/TLR4/CD8B/SRC/RPS6KA6/MAPK10/NFATC3/PIK3R3/DOCK1/FN1/MEFV/CCL2/MAP2K3/IL6/MAP2K1/CD8A/VAV3/RAC3/ACTR3C	131
KEGG	hsa04310	Wnt signaling pathway	158/6806	167/8135	1.266e-05	5.814e-05	2.125e-05	WNT2/FZD10/WNT9B/RSPO2/LGR5/WNT3/FZD2/LRP5/CAMK2G/CCND1/RAC1/PPP3R2/CSNK2B/RUVBL1/RHOA/PLCB2/PRICKLE3/RNF43/CSNK1E/PRKCB/WNT7A/WNT8B/FRAT1/CTNNBIP1/APC2/WNT16/CTBP2/DKK1/WNT7B/PRKACA/CSNK2A2/NFATC1/DVL2/TBL1X/NOTUM/FZD1/LGR6/ZNRF3/EP300/RAC2/WNT1/MAP3K7/SMAD4/CSNK2A1/TLE3/WNT8A/BTRC/SMAD3/SENP2/NKD1/CHD8/SOST/ROCK2/CER1/MAPK9/PRICKLE4/FZD9/CTNND2/CCND3/RSPO3/BAMBI/FBXW11/PPP3CA/RSPO4/PORCN/GSK3B/NFATC2/JUN/PLCB4/PSEN1/CUL1/TCF7/PPARD/FRZB/MYC/CXXC4/WNT10B/TLE2/CAMK2A/CCND2/PPP3CB/CSNK1A1/DVL3/SOX17/TBL1XR1/CAMK2B/PPP3CC/SFRP5/DKK2/TLE4/CACYBP/PLCB3/RBX1/WNT4/RYK/PRKACB/PRKACG/DAAM1/DVL1/TLE1/SFRP4/SERPINF1/CAMK2D/SKP1/CBY1/CTNNB1/TP53/MAPK8/PRICKLE2/VANGL1/PLCB1/PRKCG/SIAH1/TBL1Y/AXIN1/PRKCA/ROR2/SFRP2/PPP3R1/WIF1/CTBP1/TLE6/MAPK10/WNT5B/LEF1/FZD5/DKK4/NFATC3/TCF7L2/WNT5A/ROR1/FZD6/APC/DAAM2/LGR4/NKD2/CREBBP/FZD7/FZD8/PRICKLE1/GPC4/FRAT2/AXIN2/FZD4/LRP6/TCF7L1/RAC3/WNT11/FOSL1/NLK/WNT2B/WNT9A/WNT10A/FZD3/INVS/RSPO1/WNT6/NFATC4	158
KEGG	hsa04625	C-type lectin receptor signaling pathway	101/6806	104/8135	1.271e-05	5.814e-05	2.125e-05	IL2/IL12A/IRF1/CD209/PLK3/CALML6/PPP3R2/CARD9/RHOA/MAPK14/IL1B/PAK1/MDM2/MAPK1/PIK3CB/BCL3/SYK/LSP1/IKBKG/PIK3CD/AKT3/RRAS/PTGS2/NFATC1/HRAS/RAF1/CALM1/ITPR3/RELB/NFKBIA/CYLD/PYCARD/PLCG2/PRKCD/MAPK3/PIK3CA/NFKB1/MAPK12/IL23A/CALML4/PIK3R2/NFKB2/TNF/MAPK13/MAPK9/IKBKB/MAPKAPK2/AKT2/PIK3R1/CASP8/CLEC4M/CALML5/FCER1G/NLRP3/PPP3CA/MALT1/NFATC2/JUN/KSR1/AKT1/NRAS/ITPR1/CALML3/PPP3CB/MAPK11/IRF9/ITPR2/IL12B/CLEC4E/CHUK/IL10/IKBKE/CLEC7A/CLEC4D/CBLB/PPP3CC/MAP3K14/KRAS/CASP1/MAPK8/CLEC1B/CALM2/RELA/CALM3/PPP3R1/SRC/IL17D/MAPK10/NFATC3/STAT2/PIK3R3/CCL17/STAT1/RRAS2/PTPN11/IL6/BCL10/CCL22/MRAS/EGR2/NFATC4	101
KEGG	hsa05140	Leishmaniasis	76/6806	77/8135	1.637e-05	7.389e-05	2.701e-05	IL12A/ITGB2/PTPN6/NFKBIB/TGFB1/TGFB2/IFNGR2/MAPK14/NCF4/IL1B/PRKCB/MAPK1/IRAK1/NCF1/MYD88/PTGS2/FCGR2A/NCF2/HLA-DRA/NFKBIA/IRAK4/ITGA4/MAP3K7/ITGAM/MAPK3/EEF1A1/NFKB1/MAPK12/TRAF6/C3/JAK1/FOS/TNF/MAPK13/EEF1A2/ELK1/IL4/CYBA/TAB2/FCGR2C/CYBB/TAB1/JUN/JAK2/HLA-DMA/MARCKSL1/MAPK11/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/ITGB1/IL10/IFNG/HLA-DRB3/HLA-DRB5/TLR2/IFNGR1/FCGR1A/HLA-DOA/FCGR3B/FCGR3A/CR1L/RELA/HLA-DPA1/TLR4/HLA-DPB1/CR1/STAT1/HLA-DOB/HLA-DQA1/HLA-DQA2/NOS2/TGFB3/IL1A	76
KEGG	hsa04932	Non-alcoholic fatty liver disease	147/6806	155/8135	1.693e-05	7.539e-05	2.756e-05	ADIPOQ/COX6A2/COX4I2/COX8C/NDUFS7/NDUFS1/UQCRQ/ADIPOR2/UQCRB/NDUFC1/NDUFA1/NDUFS2/NDUFV2/PPARA/ATF4/NDUFB10/BCL2L11/COX5B/SDHB/TGFB1/NDUFB3/RAC1/NDUFB11/UQCRH/MAPK14/NDUFB4/IL1B/BAX/CASP3/NDUFA2/NDUFA7/NDUFA10/COX7B/UQCR10/COX8A/PIK3CB/NDUFB8/XBP1/NDUFS8/NDUFA13/COX6B1/PIK3CD/AKT3/IL6R/UQCRFS1/UQCRC2/GSK3A/NDUFB2/NDUFS4/TNFRSF1A/NDUFB6/EIF2S1/NDUFA12/PRKAB1/COX6B2/SDHA/COX4I1/NDUFA4/MLX/CYC1/BID/NDUFA3/NDUFV1/PIK3CA/NFKB1/NDUFA8/MAPK12/NDUFS3/NDUFC2/FAS/NDUFA11/COX6C/UQCR11/PIK3R2/NDUFA9/DDIT3/RXRA/NDUFA6/CDC42/FOS/TNF/MAPK13/MAPK9/IKBKB/SDHC/COX7A2/IRS2/PRKAG2/TRAF2/NDUFAB1/AKT2/PIK3R1/CASP8/MAP3K5/NDUFB7/NDUFB9/GSK3B/JUN/MAP3K11/NDUFV3/MLXIP/NDUFS5/AKT1/EIF2AK3/PRKAA1/COX5A/NDUFS6/COX7B2/COX6A1/NDUFA5/MAPK11/COX7C/LEP/IRS1/ITCH/SDHD/SREBF1/PRKAG1/PKLR/NDUFB1/CEBPA/CYCS/NR1H3/NDUFB5/FASLG/INS/MAPK8/INSR/SOCS3/RELA/UQCRC1/CASP7/MAPK10/PIK3R3/ADIPOR1/PRKAG3/CYP2E1/NDUFA4L2/PRKAB2/IL6/COX7A2L/PRKAA2/LEPR/PPARG/ERN1/MLXIPL/IL1A	147
KEGG	hsa05142	Chagas disease	99/6806	102/8135	1.724e-05	7.577e-05	2.77e-05	IL2/IFNB1/IL12A/GNAQ/PPP2CA/GNA15/TGFB1/PPP2R2D/TGFB2/IFNGR2/PLCB2/MAPK14/TICAM1/PPP2R2C/IL1B/GNAI1/MAPK1/PIK3CB/IRAK1/CFLAR/IKBKG/PPP2R2A/MYD88/PIK3CD/AKT3/FADD/TNFRSF1A/NFKBIA/GNA11/PPP2R1A/IRAK4/MAPK3/PIK3CA/NFKB1/MAPK12/TRAF6/TLR9/MAP2K4/C3/FAS/PIK3R2/FOS/TNF/MAPK13/MAPK9/IKBKB/AKT2/TGFBR2/PIK3R1/CD3D/CASP8/GNAI2/SMAD2/C1QB/GNAI3/GNAS/JUN/PLCB4/AKT1/C1QA/CCL5/GNAO1/CD3G/MAPK11/IL12B/CHUK/IL10/CALR/IFNG/TLR2/PPP2R2B/PLCB3/KNG1/IFNGR1/CD247/FASLG/TLR6/PPP2CB/MAPK8/SERPINE1/PLCB1/RELA/TLR4/TGFBR1/MAPK10/PIK3R3/ACE/CCL2/IL6/CD3E/CCL3/CCL3L1/CCL3L3/NOS2/TGFB3/C1QC/ADCY1/GNA14/GNAL	99
KEGG	hsa05133	Pertussis	75/6806	76/8135	1.936e-05	8.186e-05	2.993e-05	IL12A/IRF1/ITGB2/C1R/ITGA5/CALML6/RHOA/MAPK14/TICAM1/CFL1/IL1B/GNAI1/CASP3/SFTPA1/MAPK1/CD14/IRAK1/MYD88/CALM1/IRAK4/PYCARD/IRF3/ITGAM/C2/MAPK3/NFKB1/MAPK12/TRAF6/C3/IL23A/CALML4/FOS/TNF/MAPK13/MAPK9/C4BPB/NOD1/GNAI2/CALML5/C1QB/NLRP3/GNAI3/JUN/C1QA/CALML3/TIRAP/MAPK11/IL12B/ITGB1/IL10/CASP1/LY96/MAPK8/CALM2/RELA/C5/C1S/CALM3/TLR4/CASP7/MAPK10/CXCL6/CFL2/SFTPA2/IRF8/IL6/TICAM2/C4A/C4B/C4BPA/SERPING1/NOS2/C1QC/CXCL5/IL1A	75
KEGG	hsa05212	Pancreatic cancer	75/6806	76/8135	1.936e-05	8.186e-05	2.993e-05	BAD/CASP9/CCND1/TGFB1/RAC1/TGFB2/BAX/GADD45B/MAPK1/RALGDS/PIK3CB/ARAF/BAK1/IKBKG/PIK3CD/AKT3/RAF1/RPS6KB2/E2F1/RAC2/RALB/PLD1/SMAD4/MTOR/MAPK3/PIK3CA/PLD2/NFKB1/SMAD3/JAK1/PIK3R2/CDC42/MAPK9/IKBKB/ARHGEF6/AKT2/TGFBR2/PIK3R1/SMAD2/AKT1/DDB2/CDKN2A/POLK/CDK4/CHUK/VEGFA/RAD51/ERBB2/TGFA/KRAS/RPS6KB1/RB1/BRAF/CDK6/TP53/MAPK8/E2F3/RALBP1/GADD45A/EGF/BCL2L1/CDKN1A/RELA/RALA/STAT3/TGFBR1/MAPK10/GADD45G/PIK3R3/BRCA2/STAT1/MAP2K1/TGFB3/RAC3/EGFR	75
KEGG	hsa05220	Chronic myeloid leukemia	75/6806	76/8135	1.936e-05	8.186e-05	2.993e-05	BAD/GRB2/CCND1/TGFB1/MAP2K2/TGFB2/HDAC2/CRKL/RUNX1/BAX/MDM2/GADD45B/MAPK1/HDAC1/PIK3CB/STAT5B/ARAF/BAK1/CTBP2/IKBKG/PIK3CD/AKT3/SHC1/HRAS/STAT5A/RAF1/E2F1/NFKBIA/SHC3/SMAD4/MAPK3/PIK3CA/NFKB1/SMAD3/PIK3R2/IKBKB/AKT2/TGFBR2/PIK3R1/CDKN1B/SOS1/AKT1/SOS2/NRAS/MYC/ABL1/DDB2/CDKN2A/POLK/GAB2/CRK/CDK4/CHUK/KRAS/RB1/BCR/BRAF/CDK6/TP53/E2F3/GADD45A/BCL2L1/CDKN1A/RELA/SHC4/TGFBR1/CTBP1/GADD45G/PIK3R3/PTPN11/MAP2K1/CBL/MECOM/TGFB3/SHC2	75
KEGG	hsa04360	Axon guidance	171/6806	182/8135	2.074e-05	8.66e-05	3.166e-05	EFNA3/UNC5D/PLXNA3/TRPC5/RGMA/PLXNA2/CAMK2G/DCC/RAC1/PPP3R2/RHOD/DPYSL5/SEMA3B/FYN/NTN1/PARD6A/RHOA/CFL1/PAK1/GNAI1/EFNA4/SEMA6B/PAK2/UNC5A/SEMA4B/MAPK1/PIK3CB/ILK/FES/NCK2/SSH1/SRGAP3/SEMA3G/PIK3CD/SSH2/RRAS/NCK1/HRAS/LRRC4/RAF1/NGEF/SEMA6C/RAC2/ROBO3/ROCK1/LIMK1/EPHB6/PLCG2/SEMA4A/SEMA4D/MAPK3/PIK3CA/SHH/CDK5/ABLIM3/PLXNC1/PIK3R2/ROCK2/CDC42/PARD3/PIK3R1/MYL12A/MYL12B/GNAI2/RND1/BMP7/ABLIM2/RGS3/SEMA3F/PPP3CA/LRIG2/GNAI3/PLXNA4/GSK3B/NFATC2/PRKCZ/EPHA4/NRAS/LIMK2/SLIT1/ABL1/EPHA6/CAMK2A/SSH3/NTN3/PPP3CB/ITGB1/EPHB4/CAMK2B/MYL9/NTN4/PLXNB2/EPHA1/PPP3CC/KRAS/SRGAP2/WNT4/RYK/CXCR4/PTK2/PAK4/PLXNB1/SLIT2/RASA1/PDPK1/EPHA8/DPYSL2/CAMK2D/SEMA5B/BOC/PARD6G/SEMA6D/SEMA4G/EPHA5/SEMA4F/UNC5B/EFNA5/BMPR1B/PRKCA/PLCG1/EPHA7/EFNA1/NTNG2/PTCH1/PPP3R1/SEMA4C/ABLIM1/SRC/PLXNB3/WNT5B/PAK3/UNC5C/NFATC3/MYL5/EFNA2/SLIT3/SEMA5A/PIK3R3/EPHB2/WNT5A/EFNB3/CFL2/SEMA3A/PTPN11/EFNB2/LRRC4C/PAK6/BMPR2/EPHA3/SEMA3E/SEMA7A/CXCL12/PARD6B/L1CAM/SEMA3D/TRPC4/SEMA3C/TRPC3/PLXNA1/NEO1/TRPC1/RAC3/TRPC6/MET/ENAH/ROBO1/ROBO2/FZD3/EPHB1/NFATC4/EFNB1	171
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	429/6806	476/8135	2.197e-05	9.06e-05	3.312e-05	COX6A2/ATXN3L/WNT2/COX4I2/FZD10/SLC25A31/NOX1/COX8C/WNT9B/RYR3/NDUFS7/NDUFS1/UQCRQ/UQCRB/PIK3C3/NDUFC1/NDUFA1/GPX5/TUBA1C/WNT3/NDUFS2/PSMB4/NDUFV2/FZD2/PSMD6/PARK7/ATXN2L/GNAQ/HSPA5/BAD/CASP9/ATF4/NDUFB10/LRP5/CAMK2G/COX5B/SDHB/UBC/NDUFB3/RAC1/NDUFB11/PSMA6/ACTR10/CALML6/PSMB1/PPP3R2/MAP2K2/PSMA3/PSMD13/UQCRH/TNFRSF1B/CSNK2B/TUBA1B/VCP/PLCB2/HTT/SLC25A4/MAPK14/CACNA1C/NDUFB4/IL1B/UBA1/CSNK1E/UBE2G1/BAX/CASP3/VDAC2/PRKCB/WNT7A/NDUFA2/CAT/PSMA2/TUBA1A/NDUFA7/NDUFA10/COX7B/PSMC4/SOD1/UQCR10/DAXX/PSMC1/PSMA7/COX8A/WIPI2/BECN1/TOMM40L/MAPK1/HTRA2/WNT8B/FRAT1/ARAF/UBE2J1/FIG4/BAK1/PIK3R4/ALS2/SMCR8/PSMA5/APC2/WNT16/DCTN6/SLC25A5/CHRM3/CACNA1S/PSMD7/RAB1A/DCTN3/PSMD12/UBE2L3/DKK1/TANK/KLC1/TUBA4A/PSMC6/PSMB3/PRNP/NDUFB8/GRIA2/XBP1/NDUFS8/WNT7B/NDUFA13/UBE2J2/HSD17B10/COX6B1/PSMD9/ZFYVE1/CSNK2A2/PTGS2/PSMD4/TBK1/UQCRFS1/UQCRC2/DVL2/HRAS/NDUFB2/DNAH1/MAP1LC3A/ATP2A2/FADD/RAF1/NDUFS4/MAP1LC3B/NRBF2/DLG4/TNFRSF1A/NDUFB6/CALM1/EIF2S1/NDUFA12/ACTR1A/FZD1/ITPR3/COX6B2/PSMA1/PINK1/SDHA/NEFL/COX4I1/NDUFA4/DNAH9/CYC1/WNT1/PSMD1/BID/DCTN1/SQSTM1/MTOR/NDUFA3/CSNK2A1/UBA7/NDUFV1/DNAL4/MAPK3/MAP1LC3C/UBA52/NFKB1/NDUFA8/ATP2A3/MAPK12/PSMB5/RB1CC1/PSMC2/TUBA3D/TUBA3E/WNT8A/CHMP2B/TUBAL3/TUBB1/NDUFS3/NDUFC2/PSMC5/CDK5/C9orf72/FAS/ACTR1B/NDUFA11/CALML4/PSMD11/COX6C/UQCR11/NDUFA9/PSEN2/CCS/KLC4/DDIT3/NDUFA6/TNF/MAPK13/MAPK9/SDHC/APAF1/COX7A2/PSMD8/FZD9/DCTN5/PSMD2/TOMM40/HAP1/TRAF2/STX1A/PSMA4/PSMB6/PPIF/NDUFAB1/ATXN1/TUBB/GPR37/AGER/APP/CASP8/DNAH17/PSMC3/CACNA1F/CALML5/PSMB7/TUBA3C/ADRM1/MAP3K5/MAP2K6/DNAH7/DNAH2/CYBB/MFN2/MAP3K10/KIF5B/NDUFB7/TRAP1/KIF5C/PPP3CA/NDUFB9/GSK3B/ATXN2/DCTN4/NDUFV3/TUBA8/RAB8A/PLCB4/RAB39B/PSEN1/NEFM/NDUFS5/GPX7/CHRNA7/DCTN2/ULK2/NRAS/ATF6/ITPR1/MAP1LC3B2/NEFH/EIF2AK3/WNT10B/COX5A/PSMD3/CASP12/SPG11/DNAL1/ATG2A/CAMK2A/NDUFS6/COX7B2/VDAC3/COX6A1/DNAI1/GRIN2D/CALML3/RAB5A/NDUFA5/ATG2B/SIGMAR1/PPP3CB/CSNK1A1/MAPK11/ITPR2/COX7C/DVL3/NOX4/SLC25A6/WDR41/SDHD/AMBRA1/CAMK2B/DERL1/ATXN1L/BDNF/TUBB6/GPX2/PPID/ATXN3/PPP3CC/NDUFB1/KRAS/DKK2/PLCB3/WNT4/CYCS/CAPN2/WIPI1/GRIN2C/NDUFB5/DVL1/FASLG/DNAH10/GRIN2B/TARDBP/PSMB2/FUS/BRAF/RYR1/CAMK2D/CACNA1D/PSMD14/DNAI2/CHRM5/CTNNB1/TUBB3/MAP2K7/CHRM1/MAPK8/PSMA8/DNAH11/ULK1/CALM2/PLCB1/BCL2L1/PRKCG/RELA/UQCRC1/KLC3/AXIN1/PRKCA/PLCG1/UBB/IFT57/GRIN2A/LRRK2/CALM3/HIP1/PPP3R1/CASP7/DNAH5/GRIN1/DNAH8/RPS27A/MAPK10/WNT5B/FZD5/DKK4/CDK5R1/SNCAIP/WNT5A/GPX1/GRIA1/FZD6/OPTN/UBE2L6/BCL2/NDUFA4L2/GRIA4/KIF5A/MAP2K3/RYR2/VDAC1/SNCA/CACNA1B/IL6/APC/VAPB/GRIA3/DNALI1/COX7A2L/FZD7/FZD8/MAPT/UCHL1/MAP2K1/MFN1/GRM1/SPTBN2/FRAT2/AXIN2/GPX8/KLC2/TRPC3/NOS2/NOS1/FZD4/CSF1/LRP6/DNAH14/DNAH3/DNAH6/SLC6A3/PRPH/TUBB2B/WNT11/WNT2B/GPX3/CAPN1/DNAH12/WNT9A/WNT10A/FZD3/ERN1/WNT6/UBE2G2/GRM5/IL1A	429
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	136/6806	143/8135	2.229e-05	9.08e-05	3.319e-05	HOXD1/WNT2/FZD10/WNT9B/ZIC3/IGF1/ESX1/PCGF6/WNT3/FZD2/OTX1/MEIS1/GRB2/MAP2K2/MAPK14/ID3/WNT7A/MAPK1/PIK3CB/WNT8B/PCGF3/SOX2/ACVR2B/APC2/WNT16/JAK3/WNT7B/HOXB1/PIK3CD/AKT3/SETDB1/DVL2/HRAS/RIF1/RAF1/FZD1/SMAD9/WNT1/SMAD4/MAPK3/PIK3CA/MAPK12/JARID2/WNT8A/SMAD3/JAK1/PIK3R2/PCGF1/ID2/MAPK13/ACVR1B/SMAD1/FZD9/IGF1R/AKT2/PIK3R1/IL6ST/POU5F1B/SMAD2/INHBB/GSK3B/JAK2/FGFR4/AKT1/TCF7/DUSP9/NRAS/ACVR1/MYC/POU5F1/FGFR2/WNT10B/SMAD5/MAPK11/DVL3/LEFTY2/HAND1/ZFHX3/KRAS/LIFR/WNT4/PCGF5/DVL1/INHBE/BMPR1A/SMARCAD1/BMI1/LIF/LHX5/CTNNB1/KLF4/ONECUT1/BMPR1B/ESRRB/AXIN1/TBX3/STAT3/FGF2/TCF3/WNT5B/FZD5/PIK3R3/WNT5A/ACVR2A/SKIL/FZD6/MYF5/ISL1/FGFR1/PCGF2/APC/BMPR2/NEUROG1/NODAL/INHBC/FZD7/FZD8/HOXA1/MAP2K1/ACVR1C/LEFTY1/REST/AXIN2/BMP4/FZD4/ID1/ID4/FGFR3/WNT11/HESX1/WNT2B/PAX6/WNT9A/WNT10A/FZD3/WNT6	136
KEGG	hsa03320	PPAR signaling pathway	74/6806	75/8135	2.29e-05	9.104e-05	3.328e-05	ADIPOQ/CYP7A1/SLC27A4/PLTP/PPARA/ACAA1/DBI/AQP7/UBC/CPT1C/ILK/CPT1A/RXRB/ACSBG2/FADS2/PLIN4/PCK1/CPT2/ACSL3/GK2/APOA1/ACADL/ACSL4/HMGCS1/PLIN5/RXRA/PLIN1/ACOX1/CYP8B1/PLIN2/ACSL1/SLC27A5/CD36/PPARD/GK/ANGPTL4/HMGCS2/SCP2/SLC27A2/SLC27A1/FABP2/PCK2/APOA5/UCP1/ACSBG1/NR1H3/PDPK1/ACSL5/FABP5/ACSL6/FABP6/CYP27A1/SCD5/CPT1B/ME3/APOC3/ACOX3/MMP1/ACOX2/ACADM/RXRG/FABP7/SCD/FABP4/SORBS1/SLC27A6/FABP3/FABP1/LPL/EHHADH/PPARG/OLR1/APOA2/ME1	74
KEGG	hsa05214	Glioma	74/6806	75/8135	2.29e-05	9.104e-05	3.328e-05	IGF1/CAMK2G/GRB2/CCND1/CALML6/MAP2K2/BAX/PRKCB/MDM2/GADD45B/MAPK1/PIK3CB/ARAF/BAK1/PDGFRB/PIK3CD/AKT3/SHC1/HRAS/RAF1/CALM1/E2F1/SHC3/MTOR/PLCG2/MAPK3/PIK3CA/PTEN/CAMK1D/CALML4/PIK3R2/IGF1R/AKT2/PIK3R1/CALML5/SOS1/AKT1/SOS2/NRAS/DDB2/PDGFB/CAMK2A/CDKN2A/POLK/CALML3/CDK4/CAMK2B/TGFA/KRAS/RB1/BRAF/CAMK1/CAMK2D/CDK6/TP53/E2F3/GADD45A/EGF/CALM2/PRKCG/CDKN1A/PRKCA/PLCG1/CALM3/CAMK1G/SHC4/GADD45G/PIK3R3/PDGFA/CAMK4/MAP2K1/PDGFRA/SHC2/EGFR	74
KEGG	hsa05213	Endometrial cancer	58/6806	58/8135	3.088e-05	0.0001213	4.436e-05	BAD/CASP9/GRB2/CCND1/MAP2K2/BAX/GADD45B/MAPK1/PIK3CB/ILK/ARAF/BAK1/APC2/PIK3CD/AKT3/HRAS/CTNNA1/RAF1/MAPK3/PIK3CA/PTEN/PIK3R2/ELK1/MLH1/AKT2/PIK3R1/SOS1/GSK3B/AKT1/TCF7/SOS2/NRAS/MYC/DDB2/POLK/ERBB2/KRAS/PDPK1/BRAF/CTNNB1/TP53/GADD45A/EGF/CDKN1A/CTNNA3/AXIN1/FOXO3/CTNNA2/LEF1/GADD45G/PIK3R3/TCF7L2/APC/CDH1/MAP2K1/AXIN2/TCF7L1/EGFR	58
KEGG	hsa04530	Tight junction	159/6806	169/8135	3.252e-05	0.0001263	4.617e-05	IGSF5/DLG2/TUBA1C/ARPC1A/PPP2CA/ARHGEF2/CCND1/SLC9A3R1/PPP2R2D/RAC1/ACTG1/TUBA1B/MYH9/PARD6A/CGN/RHOA/RUNX1/PPP2R2C/BVES/MYL6B/CLDN3/VASP/ARPC4/TUBA1A/CD1B/MYL6/ACTR2/ARPC1B/HSPA4/MSN/ACTN1/TUBA4A/PPP2R2A/CFTR/ARPC2/PRKACA/RAB8B/WAS/CD1D/EZR/PRKAB1/ARPC5/PPP2R1A/CLDN1/ROCK1/SYNPO/STK11/ARPC3/CLDN19/TUBA3D/TUBA3E/WHAMM/TUBAL3/CLDN23/ACTR3B/ARPC5L/ACTB/ROCK2/CDC42/MAPK9/ACTN4/MYH11/CLDN5/CLDN2/CLDN15/PRKAG2/ARHGEF18/LLGL2/LLGL1/PARD3/JAM2/MYL12A/MYL12B/RAP1A/TUBA3C/PCNA/MAP3K5/HCLS1/SYMPK/JUN/RDX/PRKCZ/TUBA8/RAB8A/CLDN4/CLDN8/TJP3/AMOT/ARHGAP17/MPP5/PRKAA1/ACTR3/CLDN9/MICALL2/CDK4/F11R/CTTN/RAP2C/ITGB1/JAM3/TJAP1/TIAM1/CLDN11/ERBB2/MYL9/PRKAG1/MAGI1/PPP2R2B/RAB13/TJP2/PRKACB/PRKACG/NEDD4/NF2/CACNA1D/PRKCI/PPP2CB/MAP2K7/MAPK8/CLDN7/EPB41L4B/MARVELD3/PARD6G/DLG3/DLG1/RAPGEF2/CLDN6/SCRIB/MPDZ/SRC/CD1C/MAPK10/AMOTL1/MYL2/PRKAG3/MPP4/CLDN16/PRKCE/PRKAB2/MYH10/MAP3K1/PARD6B/CLDN18/CD1E/CD1A/PRKAA2/CRB3/CLDN14/CGNL1/GATA4/NEDD4L/RAPGEF6/ACTR3C/MARVELD2/TJP1/OCLN/MYH14/CLDN10/CLDN20	159
KEGG	hsa04713	Circadian entrainment	94/6806	97/8135	3.678e-05	0.0001405	5.136e-05	GNG13/RYR3/GNAQ/CAMK2G/GNB1/PRKG2/KCNJ6/GNG2/CALML6/GNG5/PLCB2/GNB2/ADCY8/CACNA1C/GNAI1/PRKCB/MAPK1/GRIA2/PRKACA/CALM1/ITPR3/GNGT2/MAPK3/NOS1AP/PER2/CALML4/GNG3/MTNR1B/FOS/GNG8/KCNJ5/GNG7/GNG10/GNAI2/CALML5/ADCY6/GUCY1A2/CACNA1H/GNAI3/GNAS/GNB3/PLCB4/RASD1/ITPR1/GNAO1/GNG11/PER1/CAMK2A/GRIN2D/CALML3/GNG12/GNB5/ADCY9/ADCY4/CAMK2B/PLCB3/PRKACB/PRKACG/GRIN2C/ADCYAP1R1/GRIN2B/RYR1/CAMK2D/CACNA1D/CALM2/PLCB1/PRKCG/GNGT1/KCNJ3/ADCY7/PRKCA/CREB1/GRIN2A/MTNR1A/CALM3/GRIN1/CACNA1G/GNB4/GRIA1/CACNA1I/GRIA4/RPS6KA5/PRKG1/RYR2/ADCYAP1/GNG4/GRIA3/ADCY5/ADCY10/NOS1/ADCY3/ADCY1/ADCY2/KCNJ9	94
KEGG	hsa04610	Complement and coagulation cascades	83/6806	85/8135	3.754e-05	0.0001405	5.136e-05	CPB2/MBL2/F9/F13B/TFPI/PLAT/ITGB2/CFHR4/C1R/C9/SERPINA5/VTN/CD46/VWF/FGB/F2R/C6/CD55/ITGAM/C2/CFI/CFHR3/SERPINA1/C3/CFHR5/F2RL3/C5AR1/C4BPB/F11/KLKB1/PLG/CLU/PLAUR/ITGAX/CD59/PROC/F8/C1QB/F12/F3/C1QA/CFD/CFB/SERPIND1/C3AR1/PLAU/THBD/KNG1/PROS1/F5/PROCR/F13A1/F7/SERPINE1/CR1L/C5/C1S/MASP2/CFH/CFHR1/F2/C8A/VSIG4/SERPINC1/SERPINF2/CR1/BDKRB1/CFHR2/F2RL2/FGA/C4A/C4B/MASP1/F10/C4BPA/A2M/SERPING1/C8B/C1QC/FGG/C8G/CR2/C7	83
KEGG	hsa05223	Non-small cell lung cancer	71/6806	72/8135	3.782e-05	0.0001405	5.136e-05	RASSF5/BAD/CASP9/GRB2/CCND1/MAP2K2/BAX/PRKCB/GADD45B/MAPK1/PIK3CB/STAT5B/ARAF/BAK1/JAK3/PIK3CD/RXRB/AKT3/HRAS/STAT5A/RAF1/E2F1/RASSF1/PLCG2/MAPK3/PIK3CA/STK4/PIK3R2/RXRA/RET/AKT2/PIK3R1/SOS1/KIF5B/KIF5C/ALK/AKT1/SOS2/NRAS/HGF/DDB2/EML4/CDKN2A/POLK/CDK4/ERBB2/TGFA/KRAS/RB1/PDPK1/BRAF/CDK6/TP53/E2F3/GADD45A/EGF/PRKCG/CDKN1A/RARB/PRKCA/PLCG1/STAT3/FHIT/FOXO3/GADD45G/PIK3R3/RXRG/KIF5A/MAP2K1/EGFR/MET	71
KEGG	hsa05418	Fluid shear stress and atherosclerosis	132/6806	139/8135	3.785e-05	0.0001405	5.136e-05	CDH5/NOX1/PLAT/ARHGEF2/RAC1/CALML6/HSP90B1/MAP2K5/ACTG1/RHOA/MAPK14/IL1B/PIK3CB/KEAP1/ACVR2B/TXN/NCF1/GSTA3/MAPK7/GPC1/IKBKG/NFE2L2/PIK3CD/AKT3/DUSP1/GSTO1/NCF2/TNFRSF1A/CALM1/RAC2/MAP3K7/SQSTM1/NQO1/PIK3CA/NFKB1/GSTT1/MAPK12/MEF2A/MAP2K4/ACTB/CALML4/ITGA2B/PIK3R2/PIAS4/GSTP1/FOS/TNF/MAPK13/MAPK9/IKBKB/HSP90AB1/NOS3/CYBA/MGST3/AKT2/PIK3R1/SDC2/CALML5/SUMO3/MAP3K5/MAP2K6/JUN/PRKCZ/AKT1/PECAM1/MGST1/SUMO1/SELE/ACVR1/ICAM1/PRKAA1/PDGFB/TXN2/CALML3/IL1R2/HMOX1/MAPK11/CHUK/VEGFA/THBD/IL1R1/IFNG/MMP9/EDN1/SUMO4/PTK2/SDC1/BMPR1A/GSTO2/CTNNB1/MAP2K7/TP53/MAPK8/KLF2/HSP90AA1/GSTT2/CALM2/GSTM4/ITGAV/RELA/GSTM3/ITGB3/MEF2C/BMPR1B/MMP2/CALM3/KDR/SRC/GSTM1/MAPK10/NPPC/PIK3R3/VCAM1/ACVR2A/PDGFA/BCL2/MGST2/CAV2/SDC4/GSTA4/CCL2/SUMO2/GSTM5/BMPR2/GSTM2/TRPV4/PRKAA2/BMP4/RAC3/ASS1/CAV1/IL1A	132
KEGG	hsa04917	Prolactin signaling pathway	69/6806	70/8135	5.28e-05	0.0001917	7.007e-05	SLC2A2/LHCGR/CSN2/IRF1/GRB2/CCND1/MAP2K2/MAPK14/MAPK1/PIK3CB/STAT5B/PIK3CD/AKT3/SHC1/HRAS/STAT5A/RAF1/SHC3/MAPK3/PIK3CA/NFKB1/MAPK12/PIK3R2/FOS/GCK/MAPK13/MAPK9/SOCS5/AKT2/PIK3R1/SOS1/LHB/GSK3B/JAK2/AKT1/SOS2/NRAS/CGA/CCND2/MAPK11/PRLR/GALT/CISH/KRAS/ESR2/SOCS4/INS/MAPK8/ELF5/TH/SOCS3/RELA/STAT3/FOXO3/SHC4/SRC/ESR1/CYP17A1/MAPK10/PIK3R3/STAT1/SOCS1/SOCS7/MAP2K1/TNFRSF11A/PRL/SHC2/SOCS2/SOCS6	69
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	69/6806	70/8135	5.28e-05	0.0001917	7.007e-05	IGSF5/PTPRZ1/ATP6V1H/ATP6V0D1/RAC1/MAPK14/PAK1/CASP3/ATP6V1E2/ADAM17/ATP6V0A1/ATP6AP1/IKBKG/ATP6V1F/ATP6V1E1/NFKBIA/ATP6V1G1/TCIRG1/PLCG2/NFKB1/MAPK12/ADAM10/ATP6V0B/ATP6V1B2/MAP2K4/CXCR1/CDC42/MAPK13/ATP6V1B1/GIT1/MAPK9/ATP6V0A2/IKBKB/NOD1/ATP6V1A/ATP6V0E2/JAM2/ATP6V0D2/LYN/CXCR2/ATP6V1D/ATP6V0C/ATP6V1C1/CXCL1/JUN/ATP6V0E1/ATP6V1G3/CCL5/HBEGF/MAPK11/F11R/CHUK/JAM3/CXCL3/MAP3K14/MAPK8/RELA/PLCG1/SRC/ATP6V1G2/MAPK10/PTPN11/ATP6V0A4/TJP1/EGFR/MET/CXCL2/ATP6V1C2/CSK	69
KEGG	hsa04662	B cell receptor signaling pathway	80/6806	82/8135	6.02e-05	0.0002162	7.905e-05	PTPN6/GRB2/VAV1/NFKBIB/RAC1/BTK/PPP3R2/MAP2K2/LILRB5/LILRB2/INPPL1/PRKCB/MAPK1/PIK3CB/SYK/INPP5D/IKBKG/LILRB3/PIK3CD/CARD11/AKT3/NFATC1/HRAS/LILRA1/RAF1/NFKBIA/RAC2/PLCG2/MAPK3/PIK3CA/NFKB1/LILRA2/LILRB4/NFKBIE/PIK3R2/IFITM1/FOS/IKBKB/AKT2/PIK3R1/LILRA6/LYN/PIK3AP1/SOS1/LILRB1/PPP3CA/MALT1/GSK3B/NFATC2/JUN/CD81/AKT1/VAV2/SOS2/NRAS/LILRA3/CD19/PPP3CB/CHUK/CD72/PPP3CC/KRAS/DAPP1/RELA/CD79B/PPP3R1/FCGR2B/LILRA5/NFATC3/PIK3R3/CD79A/LILRA4/BLNK/BCL10/MAP2K1/CD22/VAV3/RAC3/RASGRP3/CR2	80
KEGG	hsa04144	Endocytosis	231/6806	251/8135	6.14e-05	0.0002182	7.975e-05	CAPZA3/GRK7/VPS25/HLA-E/CHMP4A/ARPC1A/EHD1/PDCD6IP/SPG21/ARAP1/SMURF2/ARRB1/CYTH1/ARFGEF1/GBF1/IL2RG/CHMP2A/ACAP3/FOLR2/VPS4A/GIT2/TSG101/VPS29/ARF1/VPS37B/PARD6A/RHOA/CHMP4B/AP2M1/SNX32/MDM2/RAB5B/ARPC4/RAB11A/VPS28/PSD4/CAPZB/AGAP3/ACTR2/ARRB2/ARPC1B/ARFGAP2/RAB11FIP4/ACAP1/SNX2/GRK6/VPS26B/WIPF3/RAB11B/CHMP6/SH3GL2/GRK5/EPN2/CLTA/SNX6/STAM/WASL/SNX1/ARPC2/ARF5/SNX12/CYTH4/VPS4B/VPS35/HRAS/ARF4/SH3KBP1/SH3GL1/RAB11FIP2/IQSEC1/RAB35/SMURF1/CLTC/ARAP3/WIPF1/HLA-C/RAB4A/ZFYVE16/ARPC5/SNX5/CLTB/IL2RA/PLD1/HSPA1L/ARPC3/EPN1/AGAP2/AGAP4/AGAP6/ASAP1/RAB11FIP1/PLD2/HLA-B/CHMP1B/RAB10/HSPA6/HGS/CHMP2B/ACTR3B/TRAF6/ZFYVE9/SMAD3/ARPC5L/AP2S1/PIP5K1C/USP8/HLA-A/SH3GL3/SH3GLB2/CXCR1/VPS37C/SH3GLB1/CDC42/CHMP1A/GIT1/GRK4/SNX4/AP2B1/EHD4/HSPA8/VPS45/RAB11FIP5/CLTCL1/ARFGAP3/CYTH3/HSPA1B/DNM2/PSD/IGF1R/EHD2/PARD3/TGFBR2/AGAP5/RAB22A/AP2A2/ARF3/CXCR2/SMAD2/SNX3/LDLRAP1/KIF5B/KIF5C/LDLR/PRKCZ/CBLC/RAB8A/DNM1/FGFR4/VTA1/PSD3/SNF8/SMAP2/STAMBP/RABEP1/EEA1/FGFR2/RAB31/ACTR3/ARFGEF2/CAPZA2/HSPA1A/VPS37A/STAM2/IQSEC2/HLA-G/RAB5A/IGF2R/PIP5K1A/HLA-F/SMAP1/ARF6/VPS36/ARFGAP1/ITCH/FOLR1/ACAP2/CBLB/ARAP2/VPS26A/RAB5C/CXCR4/AP2A1/NEDD4/PIP5K1B/IL2RB/WWP1/PRKCI/EHD3/EPS15/TFRC/FOLR3/PSD2/BIN1/PARD6G/ASAP3/RNF41/RUFY1/PML/DAB2/CHMP7/GRK1/WIPF2/CAPZA1/SRC/TGFBR1/RAB11FIP3/IQSEC3/RUFY2/ASAP2/EPS15L1/CHMP4C/PIP5KL1/ZFYVE27/CAV2/KIF5A/CYTH2/RAB7A/VPS37D/AMPH/HSPA2/PARD6B/CBL/PDGFRA/NEDD4L/ACTR3C/FGFR3/CAV1/EPN3/EGFR/DNAJC6/CCR5	231
KEGG	hsa04920	Adipocytokine signaling pathway	68/6806	69/8135	6.236e-05	0.0002192	8.015e-05	ADIPOQ/ADIPOR2/PPARA/NFKBIB/CPT1C/TNFRSF1B/CPT1A/IKBKG/RXRB/AKT3/ACSBG2/TNFRSF1A/PRKAB1/NFKBIA/PCK1/ACSL3/STK11/MTOR/NFKB1/G6PC/ACSL4/NFKBIE/RXRA/TNF/MAPK9/IKBKB/IRS2/PRKAG2/TRADD/TRAF2/AKT2/G6PC3/ACSL1/CD36/JAK2/AKT1/PRKCQ/PRKAA1/G6PC2/LEP/IRS4/CHUK/IRS1/PCK2/PRKAG1/ACSBG1/POMC/ACSL5/MAPK8/ACSL6/SOCS3/RELA/CAMKK2/SLC2A1/STAT3/CPT1B/MAPK10/ADIPOR1/PRKAG3/RXRG/ACACB/PRKAB2/PTPN11/PRKAA2/LEPR/NPY/SLC2A4/PPARGC1A	68
KEGG	hsa04970	Salivary secretion	90/6806	93/8135	6.707e-05	0.0002314	8.461e-05	BEST2/MUC7/HTN3/STATH/RYR3/HTN1/ADRA1D/GNAQ/TRPV6/PRKG2/CALML6/ADRA1A/PLCB2/ADCY8/PRKCB/CHRM3/MUC5B/PRKACA/ATP2B3/CALM1/ITPR3/PRH1/PRH2/LPO/PRB1/SLC9A1/ATP1B3/ATP2B2/CALML4/ATP2B1/SLC4A2/DMBT1/ATP2B4/CALML5/ADCY6/VAMP2/GUCY1A2/GNAS/SLC12A2/CAMP/PLCB4/CST4/AMY1A/AMY1B/AMY1C/AMY2A/ITPR1/BST1/CALML3/LYZ/ITPR2/ADCY9/ADCY4/ATP1A1/CST3/PLCB3/CST5/PRKACB/PRKACG/KCNN4/FXYD2/CST2/ADRB2/CALM2/PLCB1/PRKCG/ADCY7/PRKCA/PRB2/CALM3/CD38/ATP1B1/AMY2B/PRKG1/ADRA1B/ATP1A4/ADCY5/ATP1A2/ADRB1/ATP1A3/ATP1B4/NOS1/ADCY3/ADRB3/AQP5/CST1/ADCY1/LYZL1/ADCY2/KCNMA1	90
KEGG	hsa04660	T cell receptor signaling pathway	100/6806	104/8135	6.722e-05	0.0002314	8.461e-05	IL2/PTPN6/GRB2/VAV1/NFKBIB/LCP2/PPP3R2/MAP2K2/FYN/RHOA/CD4/MAPK14/PAK1/PAK2/MAPK1/PIK3CB/NCK2/IKBKG/PIK3CD/CARD11/AKT3/NFATC1/NCK1/HRAS/RAF1/NFKBIA/MAP3K7/MAPK3/PIK3CA/NFKB1/MAPK12/NFKBIE/TEC/PIK3R2/CDC42/FOS/TNF/MAPK13/MAPK9/IKBKB/IL4/PDCD1/AKT2/PIK3R1/CD3D/CSF2/SOS1/PPP3CA/MALT1/GSK3B/NFATC2/JUN/AKT1/PRKCQ/VAV2/SOS2/NRAS/CD3G/GRAP2/PTPRC/RASGRP1/CDK4/PPP3CB/MAPK11/CHUK/LAT/IL10/IFNG/LCK/CBLB/ICOS/PPP3CC/MAP3K14/KRAS/CD247/ZAP70/PAK4/MAP3K8/PDPK1/MAP2K7/MAPK8/ITK/RELA/DLG1/PLCG1/CTLA4/PPP3R1/CD8B/CD40LG/CD28/MAPK10/PAK3/NFATC3/PIK3R3/PAK6/BCL10/CD3E/MAP2K1/CD8A/VAV3	100
KEGG	hsa04611	Platelet activation	118/6806	124/8135	7.4e-05	0.0002522	9.22e-05	TLN1/GNAQ/PRKG2/GNA13/STIM1/BTK/LCP2/ACTG1/ITGA2/VWF/FYN/RHOA/PLCB2/MAPK14/ADCY8/PLA2G4D/PIK3R5/GNAI1/ARHGEF1/VASP/GP6/FGB/F2R/MAPK1/PIK3CB/GP9/RASGRP2/MYLK2/SYK/PTGS1/PIK3CD/PRKACA/AKT3/FCGR2A/PPP1CA/PPP1R12A/ITPR3/ROCK1/PLA2G4C/PLCG2/VAMP8/MAPK3/PIK3CA/MAPK12/JMJD7-PLA2G4B/PLA2G4B/PPP1CB/APBB1IP/ACTB/GP5/F2RL3/ITGA2B/PIK3R2/ROCK2/MAPK13/ORAI1/NOS3/FERMT3/PPP1CC/AKT2/GP1BB/PIK3R1/RAP1B/MYL12A/MYL12B/PLA2G4F/GNAI2/ADCY6/RAP1A/GUCY1A2/LYN/GP1BA/FCER1G/GNAI3/GNAS/PRKCZ/PLCB4/AKT1/TBXAS1/ITPR1/P2RX1/RASGRP1/PIK3CG/MAPK11/ITPR2/SNAP23/ADCY9/ADCY4/P2RY12/TLN2/ITGB1/MYLK3/PLCB3/TBXA2R/PRKACB/PRKACG/PIK3R6/PRKCI/MYLK/PLCB1/PLA2G4A/COL1A1/ADCY7/ITGB3/PTGIR/F2/SRC/PIK3R3/PRKG1/MYLK4/FGA/ADCY5/ADCY3/ADCY1/COL3A1/FGG/ADCY2/COL1A2	118
KEGG	hsa05164	Influenza A	160/6806	171/8135	7.728e-05	0.0002607	9.532e-05	IL33/IFNA2/IFNB1/IFNA1/IFNA13/IL12A/SLC25A31/CASP9/NFKBIB/ACTG1/MAP2K2/NXF1/IFNGR2/RAE1/FDPS/SLC25A4/TICAM1/ADAR/CALCOCO2/IL1B/BAX/CASP3/PRKCB/DNAJC3/DNAJB1/RAB11A/TYK2/MAPK1/PIK3CB/KPNA6/BAK1/SLC25A5/PABPN1/RAB11B/IKBKG/MYD88/PIK3CD/AKT3/TBK1/FADD/RAF1/TRAF3/TNFRSF1A/HLA-DRA/MAVS/EIF2S1/IFNAR1/NFKBIA/EP300/NUP98/IRAK4/PYCARD/BID/IRF3/MAPK3/PIK3CA/NFKB1/NXT2/ACTB/JAK1/FAS/PIK3R2/TNF/IKBKB/APAF1/TRADD/PLG/IFNA8/AKT2/CCND3/PIK3R1/CASP8/TPSB2/NLRX1/NLRP3/JAK2/NXF2/NXF2B/AKT1/HLA-DMA/CCL5/ICAM1/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/IFNA16/IRF9/KPNA1/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/HNRNPUL1/CHUK/HLA-DMB/SLC25A6/NXT1/TNFRSF10B/IKBKE/IFNG/HLA-DRB3/HLA-DRB5/TLR7/CYCS/IFNGR1/XPO1/FASLG/TMPRSS2/CASP1/CIITA/RNASEL/KPNA5/HLA-DOA/CDK6/SOCS3/RELA/DDX58/PML/TNFSF10/IL18/PRKCA/IFNA17/HLA-DPA1/TLR4/KPNA2/STAT2/PIK3R3/HLA-DPB1/TMPRSS4/IFIH1/CPSF4/IRF7/TNFRSF10A/STAT1/CCL2/VDAC1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/TRIM25/MX2/CREBBP/MAP2K1/TPSD1/EIF2AK2/PRSS2/PRSS3/MX1/IFNAR2/TMPRSS11D/OAS1/TPSAB1/RSAD2/IL1A	160
KEGG	hsa05130	Pathogenic Escherichia coli infection	183/6806	197/8135	8.325e-05	0.0002781	0.0001017	TUBA1C/ARPC1A/PTPN6/CASP9/SEC24C/NFKBIB/ARHGEF2/CYTH1/SLC9A3R1/GNA13/RAC1/CYFIP2/GAPDH/ACTG1/ARF1/FYN/TUBA1B/MYH9/RHOA/MAPK14/IL1B/NCKAP1L/PAK1/BAX/CASP3/ARHGEF1/CLDN3/TMBIM6/ARPC4/TUBA1A/MYO1F/PAK2/ACTR2/F2R/ARPC1B/MAPK1/BAK1/IRAK1/RAB1A/NCK2/WIPF3/TUBA4A/IKBKG/MYD88/WASL/ARPC2/CYTH4/FCGR2A/NCK1/LPAR4/FADD/EZR/TNFRSF1A/SEC24B/NFKBIA/WIPF1/RIPK1/ARPC5/IRAK4/CLDN1/PYCARD/ROCK1/MAP3K7/ARPC3/MAPK3/CLDN19/CASP4/NFKB1/MAPK12/TUBA3D/TUBA3E/TUBAL3/CLDN23/ACTR3B/TRAF6/TUBB1/ARPC5L/ACTB/FAS/BAIAP2/ROCK2/WASF3/CDC42/FOS/ABCF2/TNF/MAPK13/MAPK9/IKBKB/TLR5/LPAR2/MYH11/CLDN5/CLDN2/CLDN15/CYTH3/TRADD/TRAF2/TAB2/TUBB/CASP8/LPAR1/MYO1A/MYO1D/MYO1C/TUBA3C/HCLS1/ARHGEF11/NLRP3/NAIP/TAB1/JUN/TUBA8/CLDN4/CLDN8/MYO1E/SEC24D/TMED10/RPS3/MYO6/ABL1/ACTR3/CLDN9/TIRAP/MAPK11/CYFIP1/ARF6/CTTN/CHUK/ITGB1/CLDN11/TNFRSF10B/TAB3/IL1R1/TUBB6/CYCS/MYO5B/FASLG/CASP1/MYO1G/WASF2/TUBB3/LPAR5/MAPK8/CLDN7/RELA/TNFSF10/IL18/GNA12/WIPF2/CLDN6/MYO10/TLR4/CASP7/F2/SRC/MAPK10/PAK3/MYO1H/NCKAP1/NLRP4/TNFRSF10A/CLDN16/SEC24A/CYTH2/PTPN11/NCL/IL6/MYO5A/MYH10/MYO5C/ABI1/CLDN18/CLDN14/MYO1B/WASF1/ACTR3C/TJP1/TUBB2B/OCLN/MYH14/CLDN10/CLDN20	183
KEGG	hsa05221	Acute myeloid leukemia	66/6806	67/8135	8.695e-05	0.0002875	0.0001051	BAD/GRB2/CCND1/MAP2K2/RUNX1/MAPK1/PIK3CB/STAT5B/ARAF/CD14/SPI1/BCL2A1/IKBKG/KIT/PIK3CD/AKT3/HRAS/STAT5A/RAF1/RPS6KB2/EIF4EBP1/CSF1R/MTOR/ITGAM/MAPK3/PIK3CA/NFKB1/RARA/PER2/PIK3R2/IKBKB/AKT2/PIK3R1/CEBPE/CSF2/SOS1/AKT1/TCF7/PPARD/SOS2/NRAS/MYC/CHUK/IL3/KRAS/CEBPA/RPS6KB1/BRAF/FCGR1A/CCNA2/RELA/PIM2/PML/STAT3/FLT3/RUNX1T1/LEF1/MPO/PIK3R3/TCF7L2/PIM1/DUSP6/ZBTB16/MAP2K1/TCF7L1/CCNA1	66
KEGG	hsa05146	Amoebiasis	98/6806	102/8135	8.949e-05	0.0002902	0.0001061	SERPINB4/SERPINB3/IL12A/ITGB2/LAMB1/GNAQ/C9/GNA15/TGFB1/TGFB2/PLCB2/IL1B/CASP3/PRKCB/RAB5B/CD1B/PIK3CB/SERPINB6/CD14/VCL/ACTN1/PIK3CD/PRKACA/LAMA2/CD1D/GNA11/ITGAM/PIK3CA/NFKB1/PIK3R2/TNF/LAMA3/ACTN4/HSPB1/MUC2/PIK3R1/CSF2/GNAS/CXCL1/PLCB4/PRDX1/LAMA1/COL4A3/LAMC3/ARG2/RAB5A/IL1R2/COL4A2/IL12B/IL10/CXCL3/IL1R1/IFNG/TLR2/PLCB3/RAB5C/PRKACB/COL4A5/PRKACG/COL4A6/PTK2/LAMC1/PLCB1/PRKCG/RELA/COL1A1/LAMA5/LAMB4/PRKCA/LAMB2/TLR4/C8A/RAB7B/CD1C/LAMC2/PIK3R3/ARG1/FN1/COL4A1/RAB7A/IL6/LAMB3/CD1E/CD1A/NOS2/TGFB3/C8B/COL4A4/ADCY1/COL3A1/CTSG/GNA14/C8G/GNAL/CXCL2/LAMA4/SERPINB10/COL1A2	98
KEGG	hsa04120	Ubiquitin mediated proteolysis	134/6806	142/8135	8.952e-05	0.0002902	0.0001061	UBE2U/SYVN1/RHOBTB2/UBE2I/SMURF2/UBC/UBE2K/UBE4B/ANAPC10/CUL7/UBA1/UBE2Q1/UBE2G1/MDM2/KLHL9/UBOX5/WWP2/CUL3/HERC1/ANAPC2/KEAP1/UBE2J1/ANAPC7/UBE2L3/UBE2J2/UBE2R2/ANAPC1/RNF7/MGRN1/UBE4A/FBXO2/CUL2/STUB1/UBE2A/SMURF1/UBA7/UBE2D2/HERC2/UBA52/HERC3/ANAPC16/UBE2Z/PIAS3/BTRC/TRAF6/KLHL13/PIAS4/XIAP/TRIP12/UBE2F/UBE3A/TRIM37/ANAPC5/UBE2C/UBE2QL1/ANAPC13/CDC27/SKP2/UBA3/UBE2NL/UBR5/DDB1/BRCA1/CUL4B/ANAPC4/FZR1/UBE2D1/PRPF19/RCHY1/FBXO4/CDC26/FBXW11/UBE2E3/CBLC/CUL1/UBE2D3/HERC4/UBE2M/AIRE/BIRC6/ANAPC11/DDB2/PPIL2/CUL4A/UBE2B/FBXW7/UBA6/BIRC7/ERCC8/BIRC2/ITCH/UBE3C/CBLB/UBE2N/RBX1/CUL5/RHOBTB1/NEDD4/UBE2S/CDC34/WWP1/SKP1/UBE2W/UBA2/CDC16/SAE1/SOCS3/FANCL/UBE2D4/UBE2O/SIAH1/PML/PIAS1/UBB/UBE2E1/UBE2Q2/RPS27A/HUWE1/TRIM32/UBE2L6/SOCS1/DET1/MAP3K1/CDC23/FBXW8/MID1/BIRC3/CBL/UBE2H/NEDD4L/UBE2E2/UBE3B/VHL/UBE2G2	134
KEGG	hsa05032	Morphine addiction	88/6806	91/8135	9.038e-05	0.0002902	0.0001061	GABRA6/GNG13/GABRE/GABRA4/GABRR1/PDE8A/PDE1A/GABRA2/GABRG2/SLC32A1/GABRB1/ARRB1/GNB1/KCNJ6/GNG2/GNG5/GNB2/ADCY8/GNAI1/PRKCB/PDE4D/ARRB2/GRK6/PDE4B/GRK5/PRKACA/GNGT2/GABRP/GNG3/GRK4/GNG8/KCNJ5/GNG7/GNG10/GNAI2/ADCY6/PDE1B/PDE3A/GABBR1/GNAI3/GNAS/PDE11A/GNB3/GNAO1/GABRA1/ADORA1/GNG11/PDE7B/GNG12/GNB5/ADCY9/ADCY4/DRD1/PRKACB/PRKACG/PDE10A/PDE3B/PDE2A/GABRA3/PRKCG/GNGT1/KCNJ3/ADCY7/GABRR2/PRKCA/GABRG1/GABRG3/GABRB3/GABBR2/PDE7A/GABRD/GNB4/PDE4A/PDE4C/CACNA1B/GABRR3/GNG4/OPRM1/ADCY5/CACNA1A/GABRA5/ADCY3/PDE1C/ADCY1/GABRB2/ADCY2/PDE8B/KCNJ9	88
KEGG	hsa04612	Antigen processing and presentation	76/6806	78/8135	0.0001126	0.0003581	0.0001309	HLA-E/HSPA5/CD4/TAPBP/HSPA4/IFI30/HLA-DRA/HLA-C/TAP1/PSME1/HSPA1L/CTSS/HLA-B/RFXAP/LGMN/HSPA6/PSME2/HLA-A/TNF/HSPA8/HSP90AB1/HSPA1B/PSME3/CD74/B2M/KIR3DL2/NFYC/KIR2DL4/HLA-DMA/KIR2DL2/NFYA/CTSB/HSPA1A/RFXANK/HLA-G/KIR2DS5/KIR2DL1/HLA-F/PDIA3/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/KIR2DS2/KIR2DS4/TAP2/CALR/IFNG/HLA-DRB3/HLA-DRB5/KLRD1/CIITA/HLA-DOA/KIR2DL3/KIR2DL5A/KIR2DS1/KIR2DS3/KIR3DL3/CANX/HSP90AA1/CREB1/KLRC3/HLA-DPA1/CD8B/HLA-DPB1/RFX5/NFYB/KIR3DL1/HLA-DOB/HLA-DQA1/HLA-DQA2/HSPA2/CD8A/KLRC1/KLRC2/KLRC4	76
KEGG	hsa04927	Cortisol synthesis and secretion	64/6806	65/8135	0.0001211	0.0003761	0.0001375	PDE8A/NCEH1/CREB3/GNAQ/ATF4/KCNK2/PLCB2/ADCY8/CACNA1C/CACNA1S/ATF6B/PRKACA/ITPR3/MC2R/GNA11/CYP11A1/ORAI1/STAR/CACNA1F/HSD3B2/ADCY6/CACNA1H/LDLR/GNAS/PLCB4/AGTR1/ITPR1/HSD3B1/NR4A1/ITPR2/ADCY9/ADCY4/CREB3L4/KCNK3/CREB3L2/PLCB3/PRKACB/POMC/PRKACG/CYP21A2/CREB5/CACNA1D/CREB3L1/PLCB1/ADCY7/NR0B1/ATF2/CREB1/SCARB1/CYP11B1/CYP17A1/CACNA1G/CACNA1I/ADCY5/SP1/ADCY3/PBX1/MRAP/ADCY1/CREB3L3/ADCY2/AGT/PDE8B/NR5A1	64
KEGG	hsa05321	Inflammatory bowel disease	64/6806	65/8135	0.0001211	0.0003761	0.0001375	IL2/IL12A/TGFB1/IL2RG/TGFB2/IFNGR2/IL1B/STAT6/IL12RB2/IL4R/NFATC1/HLA-DRA/NFKB1/SMAD3/IL23A/TNF/TLR5/IL17A/IL4/NOD2/IL12RB1/SMAD2/RORC/JUN/HLA-DMA/STAT4/FOXP3/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/IL21R/HLA-DMB/IL10/IFNG/HLA-DRB3/HLA-DRB5/TLR2/IFNGR1/GATA3/HLA-DOA/IL18RAP/IL13/IL22/TBX21/RELA/IL21/IL18/STAT3/HLA-DPA1/TLR4/RORA/HLA-DPB1/IL18R1/STAT1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/IL23R/TGFB3/MAF/IL17F/IL1A	64
KEGG	hsa04211	Longevity regulating pathway	86/6806	89/8135	0.0001216	0.0003761	0.0001375	ADIPOQ/IGF1/ADIPOR2/CREB3/ATF4/RPTOR/EIF4E2/ADCY8/BAX/TSC2/TSC1/CAT/EHMT2/ATG5/PIK3CB/AKT1S1/RHEB/ATF6B/PIK3CD/SESN1/PRKACA/AKT3/HRAS/RPS6KB2/PRKAB1/EIF4EBP1/STK11/MTOR/PIK3CA/SESN2/NFKB1/RB1CC1/PIK3R2/IRS2/EHMT1/PRKAG2/IGF1R/AKT2/FOXO1/PIK3R1/ADCY6/SOD2/SIRT1/AKT1/NRAS/PRKAA1/ADCY9/IRS4/ADCY4/CREB3L4/IRS1/PRKAG1/KRAS/CREB3L2/RPS6KB1/PRKACB/PRKACG/CREB5/INS/TP53/ULK1/CREB3L1/INSR/APPL1/RELA/CAMKK2/ADCY7/EIF4E/ATF2/CREB1/FOXO3/PIK3R3/ADIPOR1/PRKAG3/KL/PRKAB2/SESN3/ADCY5/CAMK4/PRKAA2/ADCY3/ADCY1/CREB3L3/ADCY2/PPARG/PPARGC1A	86
KEGG	hsa04723	Retrograde endocannabinoid signaling	139/6806	148/8135	0.0001356	0.0004154	0.0001519	GABRA6/GNG13/GABRE/SLC17A8/GABRA4/GABRR1/NDUFS7/NDUFS1/SLC17A7/NDUFC1/NDUFA1/NDUFS2/NDUFV2/GNAQ/GABRA2/NDUFB10/GABRG2/SLC32A1/GABRB1/GNB1/KCNJ6/GNG2/NDUFB3/NDUFB11/GNG5/PLCB2/GNB2/MAPK14/ADCY8/CACNA1C/NDUFB4/GNAI1/PRKCB/NDUFA2/NDUFA7/NDUFA10/MAPK1/CACNA1S/DAGLA/NDUFB8/GRIA2/NDUFS8/NDUFA13/PRKACA/PTGS2/FAAH/NDUFB2/NDUFS4/NDUFB6/NDUFA12/ITPR3/NDUFA4/GNGT2/NDUFA3/NDUFV1/GABRP/MAPK3/NDUFA8/MAPK12/NDUFS3/NDUFC2/MGLL/NDUFA11/GNG3/NDUFA9/NDUFA6/MAPK13/MAPK9/GNG8/KCNJ5/GNG7/GNG10/NDUFAB1/RIMS1/CACNA1F/GNAI2/ADCY6/NDUFB7/NDUFB9/GNAI3/NDUFV3/GNB3/PLCB4/NDUFS5/ITPR1/GNAO1/GABRA1/DAGLB/GNG11/NDUFS6/GNG12/NDUFA5/GNB5/MAPK11/ITPR2/ADCY9/ADCY4/NDUFB1/PLCB3/PRKACB/PRKACG/NDUFB5/CACNA1D/ABHD6/MAPK8/PLCB1/GABRA3/PRKCG/GNGT1/KCNJ3/ADCY7/GABRR2/SLC17A6/PRKCA/GABRG1/GABRG3/GABRB3/MAPK10/GABRD/GNB4/GRIA1/NDUFA4L2/GRIA4/CACNA1B/GABRR3/GNG4/GRIA3/ADCY5/CACNA1A/GABRA5/GRM1/ADCY3/NAPEPLD/ADCY1/GABRB2/CNR1/ADCY2/KCNJ9/GRM5	139
KEGG	hsa04929	GnRH secretion	63/6806	64/8135	0.0001429	0.0004339	0.0001586	HCN1/TRPC5/KCNN2/GNAQ/ARRB1/KCNJ6/KCNN3/MAP2K2/PLCB2/KCNJ11/CACNA1C/PRKCB/ARRB2/MAPK1/PIK3CB/GNRH1/CACNA1S/PIK3CD/AKT3/HRAS/RAF1/HCN2/ITPR3/GNA11/MAPK3/PIK3CA/PIK3R2/KCNJ5/KISS1/HCN3/AKT2/PIK3R1/CACNA1F/GABBR1/CACNA1H/LHB/PLCB4/AKT1/NRAS/ITPR1/CGA/ITPR2/KRAS/PLCB3/KCNN4/ESR2/SPP1/CACNA1D/PLCB1/PRKCG/KCNJ3/PRKCA/CACNA1G/GABBR2/PIK3R3/KCNN1/CACNA1I/TRPC4/MAP2K1/GNRH2/TRPC1/KISS1R/KCNJ9	63
KEGG	hsa04971	Gastric acid secretion	74/6806	76/8135	0.0001537	0.0004623	0.000169	GNAQ/CAMK2G/HRH2/KCNK10/CALML6/KCNK2/ACTG1/PLCB2/ADCY8/GNAI1/PRKCB/MYLK2/CHRM3/CFTR/PRKACA/EZR/CALM1/ITPR3/ATP4B/CCKBR/KCNQ1/SLC9A1/ATP1B3/ACTB/CALML4/SLC4A2/GNAI2/CALML5/ADCY6/KCNJ15/GNAI3/GNAS/PLCB4/GAST/ITPR1/CAMK2A/CALML3/KCNE2/SST/KCNJ1/ITPR2/ADCY9/ADCY4/CAMK2B/ATP1A1/MYLK3/PLCB3/PRKACB/PRKACG/CAMK2D/CALM2/MYLK/PLCB1/PRKCG/ADCY7/PRKCA/CALM3/CA2/KCNJ2/KCNJ10/SLC26A7/ATP1B1/KCNJ16/MYLK4/ATP1A4/ADCY5/ATP1A2/ATP1A3/ATP1B4/ADCY3/ADCY1/ATP4A/ADCY2/SSTR2	74
KEGG	hsa04911	Insulin secretion	83/6806	86/8135	0.0001893	0.0005646	0.0002064	KCNMB2/KCNU1/SLC2A2/KCNN2/CREB3/GNAQ/ATF4/CAMK2G/GCG/KCNN3/PLCB2/ADCY8/KCNJ11/CACNA1C/PRKCB/CHRM3/CACNA1S/RAB3A/ATF6B/PRKACA/ITPR3/GNA11/GLP1R/ATP1B3/GCK/ABCC8/KCNMB3/STX1A/CACNA1F/ADCY6/VAMP2/GNAS/PLCB4/CAMK2A/ADCY9/ADCY4/CREB3L4/CAMK2B/ATP1A1/CREB3L2/PLCB3/PRKACB/PRKACG/KCNN4/ADCYAP1R1/FXYD2/CREB5/INS/CAMK2D/CACNA1D/PDX1/CREB3L1/PLCB1/PRKCG/PCLO/ADCY7/SLC2A1/KCNMB1/ATF2/PRKCA/CREB1/ATP1B1/KCNN1/FFAR1/CCK/RYR2/RAPGEF4/ADCYAP1/SNAP25/ATP1A4/ADCY5/ATP1A2/RIMS2/ATP1A3/ATP1B4/ADCY3/KCNMB4/ADCY1/CCKAR/CREB3L3/TRPM4/ADCY2/KCNMA1	83
KEGG	hsa04213	Longevity regulating pathway - multiple species	61/6806	62/8135	0.0001988	0.0005876	0.0002148	IGF1/RPTOR/HDAC2/ADCY8/CAT/ATG5/SOD1/HDAC1/PIK3CB/AKT1S1/PIK3CD/PRKACA/AKT3/HRAS/RPS6KB2/PRKAB1/HSPA1L/MTOR/PIK3CA/HSPA6/CLPB/PIK3R2/HSPA8/IRS2/PRKAG2/HSPA1B/IGF1R/AKT2/FOXO1/PIK3R1/ADCY6/SOD2/SIRT1/AKT1/NRAS/PRKAA1/HSPA1A/ADCY9/IRS4/ADCY4/IRS1/PRKAG1/KRAS/RPS6KB1/PRKACB/PRKACG/EIF4EBP2/INS/INSR/ADCY7/FOXO3/PIK3R3/CRYAB/PRKAG3/PRKAB2/HSPA2/ADCY5/PRKAA2/ADCY3/ADCY1/ADCY2	61
KEGG	hsa00562	Inositol phosphate metabolism	71/6806	73/8135	0.0002444	0.0007161	0.0002618	PLCH1/PLCD1/PIK3C3/ITPKC/MTM1/TPI1/PLCB2/INPPL1/PIK3CB/SACM1L/FIG4/MTMR14/INPP5K/PIK3C2G/INPP5D/ITPK1/PLCH2/PIK3CD/MTMR3/INPP5E/IMPA2/ITPKB/PI4KA/PIP4K2A/INPP5B/PLCG2/PIK3CA/PTEN/PI4KB/PIP5K1C/IPPK/MTMR4/IMPA1/CDIPT/MTMR1/INPP4B/ISYNA1/PI4K2B/INPP5A/PLCD4/IPMK/PLCB4/PIKFYVE/PLCZ1/INPP4A/PI4K2A/PLCD3/PIP5K1A/PIK3CG/MTMR6/MINPP1/MTMR2/PLCB3/PIP5K1B/MIOX/PLCB1/PIK3C2A/PIP4K2B/SYNJ1/PLCG1/INPP1/ITPKA/OCRL/PIP4K2C/PIP5KL1/MTMR8/SYNJ2/INPP5F/PLCE1/MTMR7/INPP5J	71
KEGG	hsa05416	Viral myocarditis	59/6806	60/8135	0.0002763	0.0008024	0.0002934	HLA-E/CD40/ITGB2/CASP9/CCND1/RAC1/ACTG1/FYN/ABL2/CASP3/EIF4G2/ITGAL/CD55/LAMA2/HLA-DRA/HLA-C/RAC2/BID/HLA-B/ACTB/HLA-A/MYH6/CASP8/EIF4G1/DAG1/SGCB/HLA-DMA/LAMA1/SGCG/ICAM1/ABL1/HLA-G/HLA-F/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/CD86/HLA-DRB3/HLA-DRB5/MYH7/PRF1/CYCS/HLA-DOA/HLA-DPA1/CD40LG/EIF4G3/CD28/HLA-DPB1/CD80/DMD/HLA-DOB/HLA-DQA1/HLA-DQA2/SGCA/RAC3/CAV1/CXADR/SGCD	59
KEGG	hsa04620	Toll-like receptor signaling pathway	99/6806	104/8135	0.0002826	0.0008137	0.0002975	IFNA2/IFNB1/IFNA1/IFNA13/IL12A/CD40/RAC1/MAP2K2/MAPK14/TICAM1/IL1B/TLR1/MAPK1/PIK3CB/CD14/IRAK1/IKBKG/MYD88/PIK3CD/AKT3/TBK1/FADD/TRAF3/TLR8/IFNAR1/NFKBIA/RIPK1/CCL4/IRAK4/TOLLIP/MAP3K7/IRF3/MAPK3/PIK3CA/NFKB1/MAPK12/TRAF6/TLR9/MAP2K4/PIK3R2/FOS/TNF/MAPK13/MAPK9/IKBKB/TLR5/IFNA8/TAB2/AKT2/PIK3R1/CASP8/MAP2K6/TAB1/JUN/AKT1/CCL5/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/TIRAP/MAPK11/IL12B/CHUK/IKBKE/CD86/CTSK/TLR2/TLR7/SPP1/MAP3K8/TLR6/LY96/MAP2K7/MAPK8/RELA/IFNA17/TLR4/MAPK10/PIK3R3/IRF7/STAT1/CD80/MAP2K3/IL6/TICAM2/CXCL11/MAP2K1/IRF5/CCL3/CCL3L1/CCL3L3/CXCL9/IFNAR2/LBP	99
KEGG	hsa05218	Melanoma	70/6806	72/8135	0.0002851	0.0008139	0.0002975	FGF5/IGF1/FGF3/BAD/CCND1/MAP2K2/BAX/MDM2/GADD45B/MAPK1/PIK3CB/ARAF/BAK1/PDGFRB/PIK3CD/AKT3/FGF18/HRAS/RAF1/E2F1/MAPK3/PIK3CA/FGF23/PTEN/FGF7/PIK3R2/FGF1/PDGFD/FGF6/IGF1R/AKT2/PIK3R1/PDGFC/AKT1/NRAS/HGF/FGF16/MITF/DDB2/PDGFB/CDKN2A/POLK/CDK4/FGF17/KRAS/RB1/BRAF/FGF10/CDK6/TP53/E2F3/GADD45A/EGF/CDKN1A/FGF19/FGF4/FGF2/FGF22/FGF20/FGF9/GADD45G/PIK3R3/PDGFA/FGFR1/CDH1/MAP2K1/PDGFRA/FGF8/EGFR/MET	70
KEGG	hsa04140	Autophagy - animal	132/6806	141/8135	0.0003133	0.0008868	0.0003242	PIK3C3/BAD/PPP2CA/LAMP2/MLST8/RPTOR/MAP2K2/HMGB1/RRAGA/UVRAG/SNAP29/TSC2/TSC1/ATG5/WIPI2/BECN1/MAPK1/PIK3CB/ATG16L2/PIK3R4/MTMR14/SMCR8/CFLAR/RAB1A/AKT1S1/TANK/IGBP1/RHEB/PIK3CD/PRKACA/MTMR3/AKT3/RRAS/ZFYVE1/GABARAPL2/RRAGD/TBK1/HRAS/MAP1LC3A/RAF1/MAP1LC3B/NRBF2/EIF2S1/RPS6KB2/ATG4B/MAP3K7/STK11/SQSTM1/MTOR/ATG4A/PRKCD/VAMP8/MAPK3/MAP1LC3C/PIK3CA/RB1CC1/TRAF6/PTEN/C9orf72/ATG12/PIK3R2/SH3GLB1/DAPK3/MTMR4/MAPK9/IRS2/GABARAP/ATG3/ATG9A/IGF1R/BNIP3/AKT2/PIK3R1/GABARAPL1/TP53INP2/CTSD/RAB8A/RAB39B/AKT1/PRKCQ/ULK2/ATG4D/DAPK2/NRAS/ITPR1/MAP1LC3B2/EIF2AK3/PRKAA1/CTSB/RRAGC/ATG2A/ATG2B/RRAGB/ATG16L1/ATG7/IRS4/IRS1/WDR41/AMBRA1/KRAS/RPS6KB1/PRAP1/PRKACB/PRKACG/WIPI1/HIF1A/PDPK1/INS/PPP2CB/ATG9B/MAPK8/ULK1/BCL2L1/CAMKK2/ATG4C/DDIT4/RAB7B/MAPK10/RAB33B/PIK3R3/EIF2AK4/DAPK1/BCL2/RRAS2/RAB7A/LAMP1/STX17/MAP2K1/ATG10/PRKAA2/MRAS/ERN1	132
KEGG	hsa04330	Notch signaling pathway	58/6806	59/8135	0.0003256	0.0009062	0.0003313	NCSTN/HDAC2/HDAC1/DTX4/NOTCH1/ADAM17/APH1B/CTBP2/DTX3/DVL2/KAT2B/EP300/DTX1/MAML1/TLE3/MFNG/PSEN2/CIR1/RFNG/NUMB/ATXN1/SNW1/PSEN1/HES1/TLE2/MAML3/RBPJ/DVL3/DTX3L/JAG1/ATXN1L/DLL1/TLE4/JAG2/DVL1/DTX2/TLE1/PTCRA/LFNG/HEYL/HES5/PSENEN/DLL4/NUMBL/NOTCH2/MAML2/CTBP1/TLE6/DLL3/RBPJL/NCOR2/CREBBP/NOTCH3/KAT2A/HEY1/NOTCH4/HEY2/APH1A	58
KEGG	hsa04370	VEGF signaling pathway	58/6806	59/8135	0.0003256	0.0009062	0.0003313	BAD/CASP9/RAC1/PPP3R2/MAP2K2/MAPK14/PLA2G4D/PRKCB/MAPK1/PIK3CB/PIK3CD/AKT3/PTGS2/HRAS/RAF1/RAC2/MAPKAPK3/PLA2G4C/PLCG2/MAPK3/PXN/PIK3CA/MAPK12/JMJD7-PLA2G4B/PLA2G4B/PIK3R2/CDC42/MAPK13/MAPKAPK2/HSPB1/NOS3/AKT2/PIK3R1/PLA2G4F/PPP3CA/NFATC2/AKT1/NRAS/PPP3CB/MAPK11/VEGFA/PPP3CC/KRAS/PTK2/SPHK2/SH2D2A/PLA2G4A/PRKCG/PRKCA/PLCG1/KDR/PPP3R1/SRC/SPHK1/PIK3R3/MAP2K1/RAC3/SHC2	58
KEGG	hsa04962	Vasopressin-regulated water reabsorption	44/6806	44/8135	0.0003816	0.001053	0.0003851	CREB3/ARHGDIG/DYNLL1/RAB5B/RAB11A/NSF/DYNLL2/DCTN6/ARHGDIB/DYNC1H1/RAB11B/PRKACA/DYNC1LI1/STX4/DCTN1/ARHGDIA/DCTN5/DYNC1LI2/ADCY6/VAMP2/GNAS/DCTN4/DCTN2/DYNC2LI1/RAB5A/AVPR2/ADCY9/CREB3L4/CREB3L2/RAB5C/PRKACB/PRKACG/AVP/CREB5/CREB3L1/DYNC1I2/CREB1/AQP2/DYNC1I1/AQP3/AQP4/ADCY3/DYNC2H1/CREB3L3	44
KEGG	hsa04060	Cytokine-cytokine receptor interaction	267/6806	295/8135	0.0004072	0.001115	0.0004076	IL13RA2/IL33/IL2/IFNA2/IFNB1/BMP15/CNTF/CCL25/TNFRSF6B/IFNA1/IFNA13/IL12A/GHR/IFNE/GDF10/RELT/CD40/ACVRL1/TNFSF9/TNFRSF14/IL20/TGFB1/MSTN/IL2RG/CXCL13/CD70/TGFB2/IFNGR2/TNFRSF1B/IL22RA1/LTB/CD4/IL1B/LTBR/IL16/EDA/TNFRSF19/TNFRSF10D/TNFSF12/EBI3/TNFRSF10C/GDF1/BMP8A/AMH/ACVR2B/IL27RA/EPOR/IL12RB2/BMP3/IL31RA/IL4R/IL6R/IL10RA/CSF3R/TNFRSF1A/GDF11/IL17RA/IFNAR1/CSF1R/CCL4/IL2RA/TNFRSF12A/IL25/TNFSF13/CCL27/IL1F10/TNFRSF8/IL1RL1/IL20RA/CCR2/CXCR3/TNFRSF11B/CCL24/FAS/IL23A/CCL28/CXCR1/CCL19/TNF/IL11RA/ACVR1B/TNFRSF25/IL13RA1/IL17A/TNFSF15/IL4/IL10RB/IFNA8/TGFBR2/CSF2RA/IL6ST/CCR1/IL12RB1/XCR1/GDF15/BMP7/CSF2/BMP6/CCR7/CLCF1/CXCR2/TSLP/INHBB/CXCL1/IL32/CCL5/GDF9/TNFSF14/IL19/ACVR1/XCL1/XCL2/CSF2RB/CX3CR1/IL34/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IL1R2/TNFRSF13B/IFNA16/IL15/CCL21/AMHR2/IL12B/LEP/IL21R/EDA2R/CXCL16/IL3/IL10/CXCL3/TNFRSF10B/IL1R1/IL3RA/GDF5/PRLR/IFNG/CXCR6/IL1RAP/OSM/LIFR/CXCR4/IFNGR1/LTA/IL9R/IL2RB/FASLG/IL7R/INHBE/CCL1/BMPR1A/LIF/GDF3/CCL26/IL18RAP/IL20RB/TNFRSF9/IL13/GDF2/CCL14/CCL15/CRLF2/IL22/CCL13/IL17B/CSF3/CCL23/PPBP/IL21/CCR10/BMPR1B/TNFSF10/IL18/TNFRSF4/BMP8B/IL24/IFNA17/IL17C/IL27/CCL7/CCL18/PF4/TNFSF18/TNFRSF21/CCL20/EDAR/CXCR5/CCR3/CD40LG/TGFBR1/IL17D/IL1RL2/IL5RA/THPO/TNFRSF18/IL17RE/IL15RA/CXCL6/OSMR/CCL16/ACVR2A/IL9/CCL17/IL18R1/CXCL14/TNFSF13B/CNTFR/IFNW1/CTF1/TNFRSF10A/BMP5/CCL2/TNFSF8/GH1/GH2/IL6/BMPR2/CCL11/IL1RN/MPL/CCR4/NODAL/INHBC/CXCL12/CCR9/CD27/PF4V1/TNFSF4/IL7/CXCL11/IL17RB/IL23R/ACVR1C/CCL3/CCL3L1/CCL3L3/CSH1/BMP4/CSF1/CCL22/CXCL17/TNFRSF11A/PRL/TGFB3/LEPR/INHA/CXCL9/CCL8/NGFR/CXCL5/CSH2/IL26/IFNK/EPO/IFNAR2/IL17F/CXCL2/CCR6/CCR5/IL17RC/IL11/IL1A	267
KEGG	hsa05031	Amphetamine addiction	67/6806	69/8135	0.0004516	0.001217	0.0004449	CREB3/ATF4/CAMK2G/CALML6/PPP3R2/HDAC2/CACNA1C/PRKCB/HDAC1/GRIA2/ATF6B/PRKACA/PPP1CA/CALM1/PPP1CB/CALML4/FOS/STX1A/PPP1CC/CALML5/PPP3CA/GNAS/JUN/SIRT1/CAMK2A/GRIN2D/CALML3/PPP3CB/CREB3L4/DRD1/CAMK2B/MAOA/PPP3CC/CREB3L2/PRKACB/PRKACG/GRIN2C/GRIN2B/CREB5/CAMK2D/CACNA1D/CREB3L1/TH/CALM2/ARC/PRKCG/GRIN3B/ATF2/PRKCA/CREB1/GRIN2A/CALM3/PPP3R1/GRIN3A/GRIN1/SLC18A2/GRIA1/SLC18A1/FOSB/GRIA4/GRIA3/PPP1R1B/ADCY5/CAMK4/MAOB/SLC6A3/CREB3L3	67
KEGG	hsa05134	Legionellosis	56/6806	57/8135	0.0004518	0.001217	0.0004449	IL12A/ITGB2/CASP9/RAB1B/ARF1/VCP/NLRC4/IL1B/CASP3/CLK1/CD14/RAB1A/MYD88/NFKBIA/PYCARD/HSPA1L/ITGAM/EEF1A1/NFKB1/HSPA6/C3/NFKB2/TNF/EEF1A2/TLR5/APAF1/HSPA8/HSPA1B/BNIP3/CASP8/HSPD1/NAIP/CXCL1/HSF1/SEC22B/HSPA1A/IL12B/CXCL3/BCL2L13/TLR2/SAR1A/CYCS/CASP1/EEF1G/CR1L/RELA/IL18/CLK4/SAR1B/TLR4/CASP7/HBS1L/CR1/IL6/HSPA2/CXCL2	56
KEGG	hsa04940	Type I diabetes mellitus	43/6806	43/8135	0.0004566	0.00122	0.000446	IL2/IL12A/HLA-E/ICA1/IL1B/HLA-DRA/HLA-C/HLA-B/HLA-A/FAS/TNF/HSPD1/HLA-DMA/GZMB/HLA-G/HLA-F/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/PTPRN2/IFNG/CD86/HLA-DRB3/HLA-DRB5/PRF1/LTA/FASLG/INS/HLA-DOA/GAD2/HLA-DPA1/CD28/PTPRN/GAD1/HLA-DPB1/CD80/HLA-DOB/HLA-DQA1/HLA-DQA2/CPE/IL1A	43
KEGG	hsa04066	HIF-1 signaling pathway	103/6806	109/8135	0.0005243	0.00139	0.000508	LDHAL6B/ALDOB/IGF1/PGK1/CAMK2G/GAPDH/MAP2K2/ALDOA/PDHA2/IFNGR2/EIF4E2/NPPA/LTBR/PRKCB/ENO3/PGK2/ENO1/MAPK1/PIK3CB/ANGPT2/HK3/TIMP1/EGLN2/PIK3CD/AKT3/IL6R/CUL2/RPS6KB2/EP300/EIF4EBP1/MTOR/PLCG2/MAPK3/PIK3CA/NFKB1/PIK3R2/PFKP/PFKM/EGLN3/NOS3/EGLN1/IGF1R/AKT2/PIK3R1/CDKN1B/ENO2/CYBB/PDHA1/AKT1/PDK1/HK2/HKDC1/PDHB/TF/ALDOC/CAMK2A/HMOX1/LDHB/RPS6/VEGFA/ARNT/CAMK2B/ERBB2/IFNG/EDN1/LDHAL6A/RPS6KB1/RBX1/IFNGR1/HIF1A/LDHA/INS/CAMK2D/PFKL/MKNK1/TFRC/PFKFB3/SERPINE1/HK1/INSR/EGF/PRKCG/FLT1/CDKN1A/RELA/ANGPT4/SLC2A1/EIF4E/PRKCA/PLCG1/STAT3/MKNK2/TLR4/PIK3R3/BCL2/IL6/CREBBP/LDHC/MAP2K1/NOS2/EPO/EGFR/VHL	103
KEGG	hsa05332	Graft-versus-host disease	42/6806	42/8135	0.0005463	0.001433	0.0005239	IL2/HLA-E/IL1B/HLA-DRA/HLA-C/HLA-B/HLA-A/FAS/TNF/KIR3DL2/HLA-DMA/KIR2DL2/GZMB/HLA-G/KIR2DL1/HLA-F/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IFNG/CD86/HLA-DRB3/HLA-DRB5/PRF1/KLRD1/FASLG/HLA-DOA/KIR2DL3/KIR2DL5A/KIR3DL3/HLA-DPA1/CD28/HLA-DPB1/CD80/KIR3DL1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/KLRC1/IL1A	42
KEGG	hsa04640	Hematopoietic cell lineage	94/6806	99/8135	0.0005492	0.001433	0.0005239	ITGA5/ITGA2/CD4/IL1B/CD1B/GP9/CD14/EPOR/KIT/CD55/IL4R/IL6R/CD1D/CD37/CSF3R/HLA-DRA/CD33/CSF1R/ITGA4/IL2RA/ITGAM/CD34/ANPEP/CD7/GP5/ITGA2B/TNF/IL11RA/MME/IL4/CD2/CSF2RA/GP1BB/CD3D/CD59/CSF2/CD36/GP1BA/HLA-DMA/CD9/DNTT/CD3G/CD19/FLT3LG/IL1R2/HLA-DRB1/HLA-DRB4/HLA-DQB1/FCER2/HLA-DMB/CD44/IL3/IL1R1/IL3RA/HLA-DRB3/HLA-DRB5/IL9R/IL7R/FCGR1A/HLA-DOA/TFRC/CD5/CR1L/CSF3/ITGB3/HLA-DPA1/CD8B/CD24/FLT3/IL5RA/CD1C/THPO/CD38/HLA-DPB1/CR1/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/MS4A1/IL7/CD3E/CD1E/CD22/CD1A/GYPA/CD8A/CSF1/ITGA3/EPO/ITGA6/CR2/IL11/IL1A	94
KEGG	hsa04721	Synaptic vesicle cycle	75/6806	78/8135	0.0006057	0.001568	0.0005733	SLC6A1/SLC17A8/SLC17A7/ATP6V1H/ATP6V0D1/SLC32A1/CPLX3/AP2M1/ATP6V1E2/NSF/ATP6V0A1/CLTA/RAB3A/ATP6V1F/ATP6V1E1/CLTC/CLTB/ATP6V1G1/TCIRG1/STX3/ATP6V0B/ATP6V1B2/AP2S1/SYT1/ATP6V1B1/ATP6V0A2/SLC6A11/AP2B1/CLTCL1/DNM2/STX1A/ATP6V1A/ATP6V0E2/RIMS1/AP2A2/VAMP2/ATP6V0D2/STX2/ATP6V1D/ATP6V0C/ATP6V1C1/DNM1/ATP6V0E1/ATP6V1G3/SLC6A7/SLC1A1/SLC6A2/CPLX1/AP2A1/NAPA/SLC1A7/SLC17A6/STX1B/SLC1A2/ATP6V1G2/SLC18A2/SLC18A1/SLC6A5/SLC6A12/CACNA1B/SNAP25/ATP6V0A4/CACNA1A/SLC1A6/SLC6A9/SLC1A3/SLC18A3/SLC6A3/CPLX2/SLC6A13/SLC6A4/UNC13C/UNC13A/UNC13B/ATP6V1C2	75
KEGG	hsa01522	Endocrine resistance	93/6806	98/8135	0.0006264	0.001609	0.0005884	IGF1/BIK/BAD/GRB2/CCND1/MAP2K2/ABCB11/MAPK14/ADCY8/BAX/MDM2/NCOA3/MAPK1/PIK3CB/NOTCH1/ARAF/PIK3CD/PRKACA/AKT3/SHC1/HRAS/RAF1/RPS6KB2/E2F1/CYP2D6/SHC3/MTOR/MAPK3/PIK3CA/MAPK12/PIK3R2/FOS/MAPK13/MAPK9/IGF1R/AKT2/PIK3R1/CDKN1B/ADCY6/CDKN2C/SOS1/GNAS/JUN/AKT1/SOS2/NRAS/HBEGF/CDKN2A/CDK4/MAPK11/ADCY9/ADCY4/NCOR1/ERBB2/JAG1/MMP9/KRAS/DLL1/JAG2/RPS6KB1/PRKACB/RB1/PRKACG/MED1/ESR2/PTK2/BRAF/TP53/MAPK8/E2F3/CDKN1A/ADCY7/DLL4/MMP2/NOTCH2/SHC4/SRC/ESR1/DLL3/MAPK10/CARM1/PIK3R3/BCL2/ADCY5/MAP2K1/NOTCH3/SP1/ADCY3/NOTCH4/ADCY1/SHC2/EGFR/ADCY2	93
KEGG	hsa04512	ECM-receptor interaction	84/6806	88/8135	0.0006342	0.001617	0.0005912	FREM2/TNN/COL6A6/ITGA11/LAMB1/ITGA5/VTN/NPNT/THBS4/ITGA2/VWF/ITGB4/GP6/GP9/HSPG2/DSPP/LAMA2/ITGA4/GP5/ITGA2B/COL6A1/COL9A3/LAMA3/ITGA9/SV2B/THBS3/GP1BB/CD36/GP1BA/COL9A1/DAG1/TNXB/LAMA1/ITGA7/DMP1/COL4A3/THBS1/LAMC3/CD47/COL4A2/ITGA10/ITGB7/ITGB1/CD44/COL6A3/COL4A5/COMP/COL4A6/SPP1/SDC1/SV2C/LAMC1/CHAD/COL9A2/ITGAV/COL1A1/ITGB3/SV2A/LAMA5/ITGA8/LAMB4/LAMB2/THBS2/ITGB8/FREM1/LAMC2/FN1/COL4A1/SDC4/FRAS1/ITGB5/LAMB3/COL2A1/TNC/COL4A4/TNR/ITGA3/AGRN/ITGA6/LAMA4/HMMR/COL6A2/COL1A2/RELN	84
KEGG	hsa04070	Phosphatidylinositol signaling system	92/6806	97/8135	0.0007141	0.001793	0.0006556	PLCD1/PIK3C3/ITPKC/MTM1/IP6K2/CALML6/PLCB2/INPPL1/PRKCB/PIK3CB/SACM1L/MTMR14/PIK3C2G/INPP5D/ITPK1/PIK3CD/MTMR3/INPP5E/IMPA2/CALM1/ITPKB/ITPR3/PI4KA/PIP4K2A/INPP5B/PLCG2/DGKD/PIK3CA/CDS2/PTEN/PI4KB/PIP5K1C/CALML4/PIK3R2/IPPK/MTMR4/IMPA1/CDIPT/MTMR1/DGKQ/PPIP5K2/PPIP5K1/INPP4B/PIK3R1/PI4K2B/CALML5/INPP5A/DGKE/PLCD4/IPMK/PLCB4/PIKFYVE/ITPR1/PLCZ1/INPP4A/CALML3/PI4K2A/PLCD3/PIP5K1A/IP6K1/ITPR2/MTMR6/DGKI/IMPAD1/DGKA/MTMR2/PLCB3/DGKZ/PIP5K1B/CDS1/CALM2/PLCB1/PRKCG/PIK3C2A/PIP4K2B/DGKG/SYNJ1/PRKCA/IP6K3/PLCG1/INPP1/CALM3/ITPKA/PIK3R3/OCRL/PIP4K2C/MTMR8/SYNJ2/DGKB/INPP5F/PLCE1/MTMR7	92
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	92/6806	97/8135	0.0007141	0.001793	0.0006556	ARPC1A/VAV1/RAC1/CRKL/PLA2G4D/CFL1/PAK1/INPPL1/PRKCB/VASP/ARPC4/ACTR2/ARPC1B/MAPK1/PIK3CB/NCF1/SYK/INPP5D/PIK3CD/ARPC2/AKT3/FCGR2A/WAS/PLA2G6/RAF1/RPS6KB2/RAC2/ARPC5/PLD1/LIMK1/ARPC3/PLA2G4C/PLCG2/PRKCD/MAPK3/ASAP1/PIK3CA/PLD2/JMJD7-PLA2G4B/PLA2G4B/ACTR3B/ARPC5L/PIP5K1C/HCK/PIK3R2/WASF3/CDC42/GSN/DNM2/AKT2/PIK3R1/PLA2G4F/LYN/SCIN/AKT1/VAV2/LIMK2/ACTR3/PTPRC/GAB2/CRK/MARCKSL1/PIP5K1A/ARF6/LAT/RPS6KB1/PIP5K1B/FCGR1A/SPHK2/MARCKS/WASF2/FCGR3B/FCGR3A/BIN1/ASAP3/PLA2G4A/PRKCG/PRKCA/PLCG1/MYO10/FCGR2B/SPHK1/ASAP2/PIK3R3/DOCK1/CFL2/PRKCE/AMPH/MAP2K1/VAV3/WASF1/ACTR3C	92
KEGG	hsa04670	Leukocyte transendothelial migration	107/6806	114/8135	0.0008961	0.002234	0.0008166	CDH5/RASSF5/ITGB2/VAV1/RAC1/ACTG1/RHOA/MAPK14/NCF4/GNAI1/PRKCB/CLDN3/VASP/PIK3CB/PTK2B/MSN/VCL/NCF1/ACTN1/CD99/BCAR1/MYLPF/ITGAL/PIK3CD/CTNNA1/EZR/NCF2/RAC2/CLDN1/ITGA4/SIPA1/ROCK1/CD99L2/PLCG2/ITGAM/PXN/PIK3CA/CLDN19/MAPK12/CLDN23/ACTB/ARHGAP5/PIK3R2/ROCK2/CDC42/MAPK13/ACTN4/CLDN5/CLDN2/CLDN15/CYBA/ESAM/PIK3R1/RAP1B/JAM2/MYL12A/MYL12B/GNAI2/RAP1A/CYBB/GNAI3/CLDN4/CLDN8/PECAM1/VAV2/RHOH/ICAM1/MYL10/CLDN9/MAPK11/F11R/ITGB1/JAM3/CLDN11/MYL9/MMP9/CXCR4/PTK2/CTNNB1/CLDN7/ITK/PRKCG/CTNNA3/THY1/MMP2/PRKCA/PLCG1/CLDN6/CTNNA2/MYL7/MYL5/PIK3R3/VCAM1/MYL2/RAPGEF3/CLDN16/RAPGEF4/PTPN11/CXCL12/CLDN18/CLDN14/VAV3/OCLN/CTNND1/CLDN10/TXK/CLDN20	107
KEGG	hsa04012	ErbB signaling pathway	81/6806	85/8135	0.0009539	0.00236	0.0008628	BTC/BAD/CAMK2G/GRB2/MAP2K2/CRKL/PAK1/ABL2/PRKCB/PAK2/MAPK1/PIK3CB/STAT5B/ARAF/NCK2/PIK3CD/AKT3/SHC1/NCK1/HRAS/STAT5A/RAF1/RPS6KB2/EIF4EBP1/SHC3/MTOR/PLCG2/MAPK3/PIK3CA/MAP2K4/PIK3R2/MAPK9/ELK1/AKT2/PIK3R1/CDKN1B/SOS1/GSK3B/JUN/AKT1/SOS2/NRAS/HBEGF/MYC/ABL1/CAMK2A/CRK/NRG1/CAMK2B/ERBB2/CBLB/TGFA/KRAS/RPS6KB1/PTK2/PAK4/BRAF/CAMK2D/MAP2K7/MAPK8/EGF/PRKCG/CDKN1A/PRKCA/PLCG1/ERBB4/SHC4/SRC/MAPK10/PAK3/PIK3R3/EREG/PAK6/MAP2K1/CBL/ERBB3/NRG4/NRG2/SHC2/EGFR/GAB1	81
KEGG	hsa05160	Hepatitis C	145/6806	157/8135	0.0009796	0.002406	0.0008796	IFNA2/IFNB1/IFNA1/IFNA13/PPARA/BAD/CASP9/PPP2CA/GRB2/CCND1/PPP2R2D/MAP2K2/TICAM1/PPP2R2C/BAX/CASP3/CLDN3/TYK2/MAPK1/PIK3CB/ARAF/BAK1/CFLAR/IKBKG/PPP2R2A/PIK3CD/AKT3/TBK1/HRAS/FADD/RAF1/TRAF3/TNFRSF1A/MAVS/EIF2S1/IFNAR1/E2F1/NFKBIA/RIPK1/PPP2R1A/CLDN1/BID/IRF3/MAPK3/PIK3CA/CLDN19/NFKB1/CLDN23/TRAF6/JAK1/FAS/CDK2/PIK3R2/RXRA/TNF/IKBKB/APAF1/CLDN5/CLDN2/CLDN15/TRADD/TRAF2/YWHAQ/IFNA8/PSME3/AKT2/YWHAE/PIK3R1/CASP8/YWHAZ/SOS1/YWHAH/LDLR/GSK3B/YWHAG/CD81/CLDN4/CLDN8/AKT1/SOS2/NRAS/MYC/EIF2AK3/EIF2AK1/YWHAB/CLDN9/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/CDK4/IFNA16/IRF9/CHUK/CLDN11/IKBKE/IFNG/PPP2R2B/KRAS/CYCS/NR1H3/RB1/FASLG/BRAF/RNASEL/PPP2CB/CDK6/CTNNB1/TP53/CLDN7/E2F3/EGF/SOCS3/CDKN1A/RELA/DDX58/EIF3E/PIAS1/IFNA17/STAT3/CLDN6/SCARB1/STAT2/PIK3R3/EIF2AK4/IRF7/STAT1/CLDN16/MX2/CLDN18/MAP2K1/EIF2AK2/CLDN14/MX1/OCLN/EGFR/IFNAR2/OAS1/CLDN10/IFIT1/CLDN20/RSAD2	145
KEGG	hsa04072	Phospholipase D signaling pathway	137/6806	148/8135	0.001034	0.00252	0.0009212	GRB2/CYTH1/GRM6/GNA13/MAP2K2/ARF1/FYN/RHOA/PLCB2/ADCY8/PLA2G4D/PIK3R5/TSC2/TSC1/F2R/MAPK1/RALGDS/PIK3CB/PTK2B/SYK/PDGFRB/RHEB/KIT/PIK3CD/AKT3/CYTH4/RRAS/SHC1/HRAS/LPAR4/RAF1/SHC3/RALB/PLD1/AGPAT3/MTOR/PLA2G4C/PLCG2/DGKD/AGPAT2/MAPK3/PIK3CA/PLD2/JMJD7-PLA2G4B/PLA2G4B/PIP5K1C/CXCR1/PIK3R2/LPAR2/PDGFD/DGKQ/CYTH3/DNM2/AKT2/PIK3R1/PLA2G4F/LPAR1/AGPAT1/ADCY6/CXCR2/FCER1G/SOS1/PDGFC/GRM3/DGKE/PTGFR/GNAS/PLCB4/DNM1/AKT1/GRM4/GRM2/LPAR6/SOS2/NRAS/AGTR1/PDGFB/GAB2/AVPR2/PIP5K1A/PIK3CG/ADCY9/ARF6/ADCY4/DGKI/DGKA/KRAS/PLCB3/DGKZ/PIP5K1B/GRM8/AVP/FCER1A/INS/PIK3R6/SPHK2/LPAR5/INSR/EGF/PLCB1/PLA2G4A/RALA/DGKG/ADCY7/AVPR1A/GNA12/PRKCA/PLCG1/F2/SHC4/SPHK1/PIK3R3/PDGFA/AGPAT4/RRAS2/RAPGEF3/CYTH2/RAPGEF4/PTPN11/ADCY5/LPAR3/DGKB/MAP2K1/GRM7/GRM1/ADCY3/AVPR1B/PDGFRA/ADCY1/MRAS/SHC2/EGFR/GAB1/ADCY2/AGT/AGPAT5/GRM5	137
KEGG	hsa04150	mTOR signaling pathway	144/6806	156/8135	0.001088	0.002634	0.0009629	WNT2/FZD10/WNT9B/IGF1/ATP6V1H/WNT3/FZD2/LRP5/GRB2/SEC13/MLST8/RNF152/RPTOR/TELO2/MAP2K2/EIF4E2/RHOA/RRAGA/PRKCB/WNT7A/ATP6V1E2/TSC2/TSC1/WDR59/MAPK1/PIK3CB/WNT8B/MAPKAP1/WNT16/AKT1S1/FLCN/NPRL2/RHEB/WNT7B/CLIP1/STRADA/RPS6KA1/PIK3CD/AKT3/ATP6V1F/RRAGD/DVL2/HRAS/CAB39L/ATP6V1E1/RAF1/TBC1D7/TNFRSF1A/RPS6KB2/FZD1/EIF4EBP1/RPS6KA3/WNT1/ATP6V1G1/CAB39/STK11/MTOR/MAPK3/PIK3CA/SESN2/WNT8A/PTEN/ATP6V1B2/WDR24/PIK3R2/DEPDC5/TNF/ATP6V1B1/IKBKB/FZD9/RICTOR/MIOS/ATP6V1A/IGF1R/AKT2/PIK3R1/SKP2/SOS1/ATP6V1D/ATP6V1C1/GSK3B/AKT1/ATP6V1G3/ULK2/SOS2/NRAS/LPIN3/PRKAA1/WNT10B/RRAGC/PRR5L/SLC3A2/RRAGB/DVL3/RPS6/CHUK/IRS1/GRB10/SGK1/KRAS/RPS6KB1/WNT4/SLC7A5/LPIN2/DVL1/EIF4B/PDPK1/BRAF/INS/PRR5/ULK1/INSR/NPRL3/PRKCG/EIF4E/DDIT4/PRKCA/FNIP2/RPS6KA2/LPIN1/RPS6KA6/ATP6V1G2/WNT5B/FZD5/PIK3R3/WNT5A/FZD6/SEH1L/SLC38A9/STRADB/FZD7/FZD8/MAP2K1/PRKAA2/FZD4/LRP6/FNIP1/WNT11/WNT2B/WNT9A/WNT10A/FZD3/WNT6/ATP6V1C2	144
KEGG	hsa04913	Ovarian steroidogenesis	50/6806	51/8135	0.001198	0.002879	0.001053	BMP15/FSHR/HSD17B2/LHCGR/IGF1/HSD17B1/ADCY8/PLA2G4D/PRKACA/PTGS2/PLA2G4C/JMJD7-PLA2G4B/PLA2G4B/CYP11A1/CYP1A1/ACOT1/ACOT2/IGF1R/STAR/PLA2G4F/HSD3B2/ADCY6/BMP6/CYP1B1/LDLR/LHB/GNAS/HSD17B7/HSD3B1/CGA/CYP2J2/ADCY9/ADCY4/PRKACB/AKR1C3/PRKACG/INS/ALOX5/INSR/PLA2G4A/ADCY7/FSHB/SCARB1/CYP17A1/CYP19A1/ADCY5/ADCY3/ADCY1/ADCY2/ACOT4	50
KEGG	hsa04115	p53 signaling pathway	70/6806	73/8135	0.001235	0.002946	0.001077	IGF1/SERPINB5/CASP9/CCND1/BAX/CASP3/MDM2/TSC2/GADD45B/SIVA1/CCNG1/SESN1/BID/SESN2/RRM2B/PTEN/PPM1D/FAS/CDK2/APAF1/GORAB/CDK1/CD82/ATM/TP53I3/CCND3/STEAP3/CHEK2/SFN/CASP8/ZMAT3/RCHY1/THBS1/DDB2/BBC3/CDKN2A/CCND2/CDK4/GTSE1/TP53AIP1/AIFM2/TNFRSF10B/ATR/CYCS/SHISA5/CDK6/TP53/SERPINE1/MDM4/GADD45A/BCL2L1/CDKN1A/SIAH1/CCNE1/CCNE2/GADD45G/BCL2/TNFRSF10A/CCNB2/TP73/PERP/CCNG2/PMAIP1/SESN3/RPRM/CCNB1/EI24/RRM2/CHEK1/IGFBP3	70
KEGG	hsa04972	Pancreatic secretion	96/6806	102/8135	0.001261	0.002988	0.001092	CPB2/PNLIP/PLA2G2D/CLCA1/GNAQ/CELA2A/RAC1/RHOA/PLCB2/ADCY8/PRKCB/RAB11A/CHRM3/CFTR/ATP2B3/CPB1/CLCA4/ATP2A2/ITPR3/KCNQ1/SLC9A1/ATP2A3/ATP1B3/ATP2B2/ATP2B1/SLC26A3/SLC4A2/PLA2G2A/ATP2B4/RAP1B/ADCY6/RAP1A/GNAS/SLC12A2/RAB8A/PLCB4/AMY1A/AMY1B/AMY1C/AMY2A/ITPR1/BST1/CPA3/ITPR2/ADCY9/ADCY4/CTRL/ATP1A1/PLCB3/TPCN2/PNLIPRP1/FXYD2/RAB3D/CELA2B/SCT/PLCB1/PRKCG/ADCY7/PRKCA/CA2/PLA2G3/PLA2G12A/CLCA2/CTRB1/CTRB2/CD38/ATP1B1/CELA3B/PLA2G2F/AMY2B/CPA2/CCK/RYR2/PLA2G12B/PLA2G10/ATP1A4/ADCY5/ATP1A2/SLC4A4/ATP1A3/ATP1B4/PLA2G1B/PLA2G2E/PNLIPRP2/ADCY3/PRSS2/PRSS3/TRPC1/CPA1/ADCY1/CCKAR/PLA2G5/RAB27B/ADCY2/SCTR/KCNMA1	96
KEGG	hsa05216	Thyroid cancer	37/6806	37/8135	0.001339	0.00315	0.001151	CCND1/MAP2K2/BAX/GADD45B/MAPK1/BAK1/RXRB/HRAS/MAPK3/RXRA/RET/TPR/NTRK1/NCOA4/TCF7/CCDC6/NRAS/TPM3/MYC/DDB2/POLK/PAX8/KRAS/BRAF/CTNNB1/TP53/GADD45A/TFG/CDKN1A/LEF1/GADD45G/TCF7L2/RXRG/CDH1/MAP2K1/TCF7L1/PPARG	37
KEGG	hsa04979	Cholesterol metabolism	49/6806	50/8135	0.001408	0.003266	0.001194	CYP7A1/LIPG/NCEH1/PLTP/ABCB11/VDAC2/LRPAP1/SOAT1/SORT1/NPC2/TSPO/NPC1/APOA1/LRP1/LIPA/PCSK9/OSBPL5/STAR/STARD3/CD36/LDLRAP1/APOE/LDLR/ABCA1/ANGPTL4/LCAT/APOC1/VDAC3/MYLIP/ABCG5/APOA4/LPA/APOC2/APOB/CYP27A1/ABCG8/SCARB1/VAPA/APOC3/CETP/SOAT2/ANGPTL3/VDAC1/VAPB/LRP2/LPL/APOH/LIPC/APOA2	49
KEGG	hsa05110	Vibrio cholerae infection	49/6806	50/8135	0.001408	0.003266	0.001194	ATP6V1H/ATP6V0D1/ACTG1/ARF1/ATP6V1E2/ATP6V0A1/ATP6AP1/CFTR/PRKACA/ATP6V1F/ATP6V1E1/ATP6V1G1/TCIRG1/KDELR1/PLCG2/KCNQ1/SEC61B/ATP6V0B/ATP6V1B2/ACTB/SEC61A1/ATP6V1B1/ATP6V0A2/ATP6V1A/ATP6V0E2/SEC61A2/PDIA4/ATP6V0D2/SEC61G/ATP6V1D/ATP6V0C/ATP6V1C1/GNAS/SLC12A2/ATP6V0E1/ATP6V1G3/KDELR2/ADCY9/TJP2/PRKACB/PRKACG/KDELR3/PRKCA/PLCG1/ATP6V1G2/ATP6V0A4/ADCY3/TJP1/ATP6V1C2	49
KEGG	hsa04137	Mitophagy - animal	69/6806	72/8135	0.001422	0.003267	0.001194	ATF4/UBC/CSNK2B/USP15/PGAM5/CALCOCO2/TBC1D17/TOMM7/ATG5/BECN1/FUNDC1/USP30/TAX1BP1/NBR1/RRAS/GABARAPL2/CSNK2A2/TBK1/HRAS/MAP1LC3A/MAP1LC3B/E2F1/PINK1/SQSTM1/CSNK2A1/MAP1LC3C/UBA52/USP8/TFE3/MAPK9/GABARAP/CITED2/RHOT2/ATG9A/TFEB/BNIP3/GABARAPL1/MFN2/FIS1/JUN/NRAS/MAP1LC3B2/EIF2AK3/MITF/BNIP3L/AMBRA1/BCL2L13/KRAS/HIF1A/RHOT1/ATG9B/TP53/MAPK8/ULK1/BCL2L1/RELA/UBB/FOXO3/SRC/RAB7B/RPS27A/MAPK10/TBC1D15/OPTN/RRAS2/RAB7A/MFN1/SP1/MRAS	69
KEGG	hsa04146	Peroxisome	78/6806	82/8135	0.001428	0.003267	0.001194	HAO1/PEX10/ACAA1/HMGCL/ABCD1/GNPAT/MPV17L2/DAO/CAT/ECH1/SOD1/ABCD4/AMACR/PEX19/GSTK1/PMVK/PEX11B/PEX16/ACSL3/MPV17/DHRS4/HSD17B4/PEX5L/PEX12/PRDX5/ACSL4/PAOX/MLYCD/FAR1/ACOX1/PEX6/ACSL1/ACOT8/SOD2/DECR2/XDH/DDO/IDH2/PRDX1/PEX26/SCP2/SLC27A2/HACL1/PEX11A/MVK/PEX11G/CROT/MPV17L/PHYH/IDH1/CRAT/SLC25A17/FAR2/PECR/ACSL5/PEX13/AGPS/PXMP2/ACSL6/PEX1/HAO2/ABCD2/AGXT/EPHX2/PIPOX/ABCD3/PEX14/ACOX3/ACOX2/PXMP4/NUDT7/PEX2/NOS2/NUDT19/PEX3/EHHADH/BAAT/NUDT12	78
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	48/6806	49/8135	0.001654	0.003759	0.001374	MPI/UGP2/PMM1/GMDS/HK3/CYB5R3/CYB5R4/HEXB/NANS/GMPPB/PGM1/GPI/GALK1/GALE/GFPT2/GMPPA/GALK2/CMAS/HEXA/GCK/AMDHD2/NANP/CYB5R1/PGM3/TSTA3/GNPDA1/PMM2/NAGK/FPGT/HK2/HKDC1/GNPNAT1/PGM2/CHIA/NPL/GALT/CHIT1/RENBP/HK1/CYB5RL/GNPDA2/GFPT1/UXS1/UAP1/GNE/UAP1L1/UGDH/CYB5R2	48
KEGG	hsa05017	Spinocerebellar ataxia	132/6806	143/8135	0.001759	0.003947	0.001443	ATXN3L/SLC25A31/PIK3C3/PSMB4/PSMD6/ATXN2L/GNAQ/KAT5/ATXN8OS/PSMA6/PSMB1/PSMA3/PSMD13/PLCB2/SLC25A4/VDAC2/PRKCB/PSMA2/PSMC4/GTF2B/PSMC1/PSMA7/WIPI2/BECN1/PIK3CB/PIK3R4/PSMA5/SLC25A5/PSMD7/PSMD12/PSMC6/PSMB3/GRIA2/XBP1/DAB1/OMA1/KCND3/PUM1/PIK3CD/PSMD9/AKT3/PSMD4/ATP2A2/NRBF2/ITPR3/PSMA1/PSMD1/MTOR/PIK3CA/PUM2/ATP2A3/PSMB5/RB1CC1/PSMC2/PSMC5/NOP56/TBPL1/CIC/PSMD11/PIK3R2/MAPK9/PSMD8/PSMD2/TRAF2/PSMA4/PSMB6/PPIF/ATXN1/AKT2/PIK3R1/PSMC3/PSMB7/ADRM1/MAP3K5/ATXN2/PLCB4/AKT1/ULK2/ITPR1/NFYA/PSMD3/ATG2A/VDAC3/GRIN2D/ATG2B/RBPJ/ITPR2/KCNC3/SLC25A6/AMBRA1/TBP/ATXN1L/ATXN3/PLCB3/CYCS/WIPI1/GRIN2C/GRIN2B/PSMB2/RYR1/PSMD14/MAPK8/PSMA8/ULK1/PLCB1/PRKCG/GRIN3B/PRKCA/ATXN10/GRIN2A/RORA/GRIN3A/GRIN1/MAPK10/OPA1/RBPJL/PIK3R3/GRIA1/AFG3L2/FGF14/VDAC1/GRIA3/CACNA1A/SLC1A6/GRM1/SPTBN2/TRPC3/SP1/VLDLR/ERN1/MYOD1/RELN	132
KEGG	hsa05410	Hypertrophic cardiomyopathy	85/6806	90/8135	0.001761	0.003947	0.001443	IGF1/CACNB3/ITGA11/CACNB1/ITGA5/TGFB1/ACTG1/ITGA2/TGFB2/CACNA1C/ITGB4/CACNG1/CACNA1S/CACNA2D1/TNNC1/LAMA2/ATP2A2/PRKAB1/CACNG8/ITGA4/ATP2A3/CACNA2D4/ACTB/ITGA2B/TNF/MYBPC3/MYH6/PRKAG2/ITGA9/TNNT2/TPM4/CACNA2D2/CACNA1F/EMD/DAG1/SLC8A1/SGCB/LAMA1/ITGA7/TPM3/SGCG/PRKAA1/ITGA10/ITGB7/CACNA2D3/ITGB1/SLC8A3/CACNB2/PRKAG1/TPM2/EDN1/MYH7/LMNA/CACNG3/CACNA1D/DES/ACTC1/ITGAV/ITGB3/ITGA8/CACNG4/ITGB8/MYL2/CACNG5/PRKAG3/TTN/ACE/TPM1/DMD/RYR2/PRKAB2/ITGB5/IL6/CACNG2/SGCA/PRKAA2/MYL3/TGFB3/ITGA3/CACNG6/ITGA6/AGT/TNNI3/SLC8A2/SGCD	85
KEGG	hsa05230	Central carbon metabolism in cancer	67/6806	70/8135	0.001882	0.00419	0.001532	SLC2A2/LDHAL6B/PGAM1/MAP2K2/PDHA2/MAPK1/PIK3CB/HK3/PGAM2/PDGFRB/KIT/PIK3CD/AKT3/HRAS/RAF1/MTOR/G6PD/MAPK3/PIK3CA/PTEN/PIK3R2/RET/PFKP/GCK/PFKM/GLS/SIRT3/SIRT6/AKT2/PIK3R1/NTRK3/SLC16A3/NTRK1/PDHA1/AKT1/PDK1/IDH2/NRAS/HK2/HKDC1/PDHB/MYC/FGFR2/LDHB/ERBB2/IDH1/KRAS/LDHAL6A/SLC7A5/HIF1A/LDHA/PFKL/TP53/HK1/SLC1A5/SLC2A1/FLT3/PIK3R3/SCO2/GLS2/FGFR1/LDHC/MAP2K1/PDGFRA/FGFR3/EGFR/MET	67
KEGG	hsa04922	Glucagon signaling pathway	100/6806	107/8135	0.002061	0.004559	0.001667	SLC2A2/GYS2/LDHAL6B/PGAM1/PPARA/CREB3/GNAQ/ATF4/CAMK2G/CALML6/GCG/PPP3R2/CPT1C/PDHA2/PLCB2/CPT1A/FBP1/PGAM2/PPP4C/PHKG2/PHKB/PRKACA/AKT3/PRMT1/PHKA2/CALM1/PRKAB1/ITPR3/EP300/PCK1/CRTC2/PYGM/PHKG1/G6PC/CALML4/PYGL/PFKP/GCK/PFKM/PRKAG2/GYS1/AKT2/FOXO1/GCGR/G6PC3/CALML5/PPP3CA/PDHA1/GNAS/PLCB4/SIRT1/AKT1/ITPR1/PDHB/PRKAA1/CAMK2A/CALML3/G6PC2/PPP3CB/ITPR2/LDHB/CREB3L4/PCK2/CAMK2B/PRKAG1/PYGB/PPP3CC/CREB3L2/LDHAL6A/PLCB3/PRKACB/PRKACG/SIK1/CREB5/LDHA/CAMK2D/PFKL/PDE3B/CREB3L1/CALM2/PLCB1/SLC2A1/ATF2/CREB1/ACACA/CALM3/CPT1B/PHKA1/PPP3R1/PRKAG3/ACACB/PRKAB2/FBP2/CREBBP/LDHC/SIK2/PRKAA2/CREB3L3/ADCY2/PPARGC1A	100
KEGG	hsa04924	Renin secretion	66/6806	69/8135	0.002163	0.004753	0.001738	CLCA1/PDE1A/GNAQ/PRKG2/CALML6/PPP3R2/NPPA/PLCB2/CACNA1C/GNAI1/CACNA1S/PRKACA/CLCA4/CALM1/ITPR3/REN/CALML4/NPR1/ORAI1/PTGER2/CACNA1F/GNAI2/CALML5/ADCY6/PDE1B/GUCY1A2/PDE3A/PPP3CA/GNAI3/PTGER4/GNAS/PLCB4/AGTR1/ITPR1/ADORA1/CTSB/CALML3/PPP3CB/ITPR2/PPP3CC/EDN1/PLCB3/PRKACB/PRKACG/ADCYAP1R1/ADRB2/CACNA1D/PDE3B/CALM2/PLCB1/CREB1/EDNRA/CALM3/PPP3R1/KCNJ2/CLCA2/ACE/ADCYAP1/EDN2/ADCY5/ADRB1/EDN3/PDE1C/ADRB3/AGT/KCNMA1	66
KEGG	hsa04390	Hippo signaling pathway	144/6806	157/8135	0.002291	0.005	0.001828	WNT2/DLG2/FZD10/WNT9B/WNT3/FZD2/ITGB2/PPP2CA/CCND1/GLI2/TGFB1/PPP2R2D/ACTG1/TGFB2/PARD6A/PPP2R2C/CSNK1E/WNT7A/TP53BP2/WNT8B/BMP8A/AMH/SOX2/APC2/WNT16/WNT7B/PPP2R2A/DVL2/CTNNA1/PPP1CA/DLG4/FZD1/RASSF1/PPP2R1A/WNT1/CSNK1D/WTIP/SMAD4/CRB2/WNT8A/BTRC/SMAD3/PPP1CB/ACTB/NKD1/ID2/FGF1/SNAI2/SMAD1/FZD9/LLGL2/LLGL1/YWHAQ/PARD3/PPP1CC/CCND3/YWHAE/TGFBR2/LIMD1/YWHAZ/BMP7/BMP6/SMAD2/FBXW11/YWHAH/GSK3B/YWHAG/PRKCZ/TCF7/AMOT/MYC/MPP5/WNT10B/LATS2/BBC3/YWHAB/CCND2/DVL3/BIRC2/GDF5/PPP2R2B/TEAD2/WNT4/DVL1/NF2/BMPR1A/PRKCI/PPP2CB/CTNNB1/SERPINE1/PARD6G/FRMD6/DLG3/BMPR1B/DLG1/CTNNA3/TEAD4/AXIN1/BMP8B/WWC1/TEAD1/SCRIB/TGFBR1/CTNNA2/WNT5B/LEF1/FZD5/TCF7L2/WNT5A/STK3/YAP1/FZD6/CRB1/BMP5/RASSF6/TP73/APC/SAV1/BMPR2/TEAD3/DLG5/SMAD7/NKD2/FZD7/FZD8/PARD6B/BIRC3/CDH1/FRMD1/LATS1/AXIN2/BMP4/FZD4/WWTR1/TCF7L1/TGFB3/ID1/WNT11/WNT2B/BIRC5/WNT9A/WNT10A/FZD3/WNT6	144
KEGG	hsa05414	Dilated cardiomyopathy	90/6806	96/8135	0.002621	0.005684	0.002078	IGF1/CACNB3/ITGA11/CACNB1/ITGA5/TGFB1/ACTG1/ITGA2/TGFB2/ADCY8/CACNA1C/ITGB4/CACNG1/CACNA1S/CACNA2D1/TNNC1/PRKACA/LAMA2/ATP2A2/CACNG8/ITGA4/ATP2A3/CACNA2D4/ACTB/ITGA2B/TNF/MYBPC3/MYH6/ITGA9/TNNT2/TPM4/CACNA2D2/CACNA1F/EMD/ADCY6/DAG1/GNAS/SLC8A1/SGCB/LAMA1/ITGA7/TPM3/SGCG/ITGA10/ITGB7/ADCY9/CACNA2D3/ADCY4/ITGB1/SLC8A3/CACNB2/TPM2/MYH7/PRKACB/PRKACG/LMNA/CACNG3/CACNA1D/DES/PLN/ACTC1/ITGAV/ADCY7/ITGB3/ITGA8/CACNG4/ITGB8/MYL2/CACNG5/TTN/TPM1/DMD/RYR2/ITGB5/CACNG2/ADCY5/ADRB1/SGCA/MYL3/ADCY3/TGFB3/ADCY1/ITGA3/CACNG6/ITGA6/ADCY2/AGT/TNNI3/SLC8A2/SGCD	90
KEGG	hsa03410	Base excision repair	33/6806	33/8135	0.002742	0.005871	0.002146	PARP3/XRCC1/SMUG1/HMGB1/MBD4/NTHL1/POLB/MPG/POLD3/FEN1/LIG3/PARP4/POLE4/OGG1/POLL/POLE3/PARP1/NEIL1/APEX2/POLD4/PCNA/POLD1/POLE/LIG1/UNG/POLD2/APEX1/PARP2/POLE2/MUTYH/NEIL2/TDG/NEIL3	33
KEGG	hsa04130	SNARE interactions in vesicular transport	33/6806	33/8135	0.002742	0.005871	0.002146	VAMP3/STX8/VAMP5/SNAP29/STX16/YKT6/STX5/BNIP1/USE1/STX4/STX3/VAMP8/GOSR1/STX19/STX1A/STX6/VTI1B/VAMP7/VAMP2/STX2/STX18/BET1L/SEC22B/STX11/GOSR2/SNAP23/VTI1A/STX7/BET1/STX1B/VAMP1/STX17/VAMP4	33
KEGG	hsa04657	IL-17 signaling pathway	88/6806	94/8135	0.003329	0.007081	0.002589	MMP3/HSP90B1/TRAF4/MAPK14/IL1B/S100A9/CASP3/MAPK1/USP25/MAPK7/IKBKG/MUC5B/PTGS2/TBK1/FADD/TRAF3/IL17RA/NFKBIA/MAP3K7/TNFAIP3/CEBPB/IL25/MAPK3/NFKB1/MAPK12/TRAF6/FOS/TRAF3IP2/TNF/MAPK13/MAPK9/IKBKB/HSP90AB1/ANAPC5/TRADD/IL17A/MAPK6/TRAF2/IL4/TAB2/CASP8/CSF2/MUC5AC/ELAVL1/GSK3B/CXCL1/JUN/S100A8/S100A7/MAPK11/CHUK/CXCL3/IKBKE/TAB3/IFNG/MMP9/MAPK8/IL13/HSP90AA1/IL17B/CSF3/RELA/MAPK4/IL17C/CCL7/CCL20/IL17D/MMP13/MAPK10/IL17RE/CXCL6/LCN2/MMP1/CCL17/TRAF5/FOSB/DEFB4A/CCL2/JUND/IL6/CCL11/IL17RB/CXCL5/FOSL1/IL17F/CXCL2/MAPK15/IL17RC	88
KEGG	hsa05323	Rheumatoid arthritis	87/6806	93/8135	0.003748	0.007883	0.002882	PTH/MMP3/ATP6V1H/ATP6V0D1/ITGB2/TGFB1/TGFB2/LTB/IL1B/ATP6V1E2/ATP6V0A1/ATP6AP1/ITGAL/ATP6V1F/ATP6V1E1/HLA-DRA/ATP6V1G1/TCIRG1/TNFSF13/ATP6V0B/ATP6V1B2/IL23A/FOS/TNF/ATP6V1B1/ATP6V0A2/ACP5/IL17A/ATP6V1A/ATP6V0E2/CSF2/ATP6V0D2/ATP6V1D/ATP6V0C/ATP6V1C1/CXCL1/JUN/ATP6V0E1/ATP6V1G3/HLA-DMA/CCL5/ICAM1/IL15/HLA-DRB1/HLA-DRB4/HLA-DQB1/VEGFA/HLA-DMB/CXCL3/IFNG/CD86/CTSK/HLA-DRB3/HLA-DRB5/TLR2/HLA-DOA/FLT1/IL18/CTLA4/HLA-DPA1/TLR4/CCL20/CD28/ATP6V1G2/CXCL6/MMP1/HLA-DPB1/TNFSF13B/CD80/CCL2/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/ATP6V0A4/CXCL12/CCL3/CCL3L1/CCL3L3/CSF1/TNFRSF11A/TGFB3/CXCL5/CXCL2/IL11/ATP6V1C2/IL1A	87
KEGG	hsa05010	Alzheimer disease	340/6806	384/8135	0.003753	0.007883	0.002882	COX6A2/WNT2/COX4I2/FZD10/SLC25A31/NOX1/COX8C/WNT9B/RYR3/NDUFS7/NDUFS1/UQCRQ/SLC39A12/UQCRB/PIK3C3/NDUFC1/NDUFA1/TUBA1C/WNT3/NDUFS2/PSMB4/NDUFV2/FZD2/PSMD6/GNAQ/BAD/CASP9/ATF4/NCSTN/NDUFB10/IDE/LRP5/COX5B/SDHB/NDUFB3/NDUFB11/PSMA6/GAPDH/CALML6/PSMB1/PPP3R2/MAP2K2/PSMA3/PSMD13/UQCRH/CSNK2B/TUBA1B/PLCB2/SLC25A4/CACNA1C/NDUFB4/IL1B/SLC11A2/CSNK1E/CASP3/VDAC2/WNT7A/NDUFA2/SLC39A2/PSMA2/TUBA1A/APBB1/NDUFA7/NDUFA10/COX7B/PSMC4/UQCR10/PSMC1/PSMA7/COX8A/WIPI2/BECN1/MAPK1/PIK3CB/WNT8B/FRAT1/ARAF/ADAM17/SLC39A7/APH1B/PIK3R4/PSMA5/APC2/WNT16/SLC25A5/CHRM3/CACNA1S/PSMD7/PSMD12/DKK1/BACE1/KLC1/TUBA4A/PSMC6/PSMB3/NDUFB8/XBP1/NDUFS8/WNT7B/NDUFA13/HSD17B10/IKBKG/COX6B1/PIK3CD/PSMD9/AKT3/CSNK2A2/PTGS2/PSMD4/UQCRFS1/UQCRC2/DVL2/SLC39A4/HRAS/SLC39A13/NDUFB2/ATP2A2/FADD/RAF1/NDUFS4/NRBF2/TNFRSF1A/NDUFB6/CALM1/EIF2S1/NDUFA12/FZD1/ITPR3/COX6B2/PSMA1/SDHA/SLC39A3/COX4I1/NDUFA4/CYC1/WNT1/PSMD1/BID/MTOR/NDUFA3/CSNK2A1/NDUFV1/MAPK3/PIK3CA/NFKB1/NDUFA8/ATP2A3/ADAM10/PSMB5/RB1CC1/PSMC2/TUBA3D/TUBA3E/WNT8A/TUBAL3/TUBB1/NDUFS3/NDUFC2/PSMC5/CDK5/LRP1/RTN4/FAS/NDUFA11/CALML4/PSMD11/COX6C/UQCR11/PIK3R2/NDUFA9/PSEN2/KLC4/DDIT3/NDUFA6/TNF/MAPK9/IKBKB/SDHC/APAF1/SLC39A11/COX7A2/IRS2/PSMD8/MME/FZD9/PSMD2/TRAF2/PSMA4/PSMB6/PPIF/NDUFAB1/AKT2/TUBB/AGER/PIK3R1/APP/CASP8/PSMC3/CACNA1F/CALML5/SLC39A6/PSMB7/TUBA3C/ADRM1/MAP3K5/CYBB/APOE/KIF5B/NDUFB7/KIF5C/PPP3CA/NDUFB9/GSK3B/NDUFV3/TUBA8/PLCB4/PSEN1/NDUFS5/AKT1/CHRNA7/BACE2/ULK2/SLC39A8/NRAS/ATF6/ITPR1/EIF2AK3/WNT10B/SLC39A9/COX5A/PSMD3/CASP12/ATG2A/NDUFS6/COX7B2/VDAC3/COX6A1/NAE1/GRIN2D/CALML3/NDUFA5/ATG2B/PPP3CB/CSNK1A1/ITPR2/COX7C/DVL3/IRS4/NOX4/CHUK/IRS1/SLC25A6/RTN3/SDHD/AMBRA1/TUBB6/PPID/PPP3CC/NDUFB1/KRAS/DKK2/PLCB3/WNT4/CYCS/CAPN2/WIPI1/GRIN2C/NDUFB5/DVL1/GRIN2B/PSMB2/BRAF/INS/CACNA1D/PSMD14/CHRM5/CTNNB1/TUBB3/MAP2K7/CHRM1/MAPK8/PSMA8/ULK1/INSR/CALM2/PLCB1/RELA/UQCRC1/PSENEN/KLC3/SLC39A10/AXIN1/GRIN2A/CALM3/PPP3R1/CASP7/GRIN1/MAPK10/WNT5B/FZD5/DKK4/CDK5R1/PIK3R3/WNT5A/FZD6/NDUFA4L2/KIF5A/VDAC1/SNCA/IL6/APC/COX7A2L/FZD7/FZD8/MAPT/MAP2K1/EIF2AK2/FRAT2/AXIN2/KLC2/NOS2/NOS1/FZD4/CSF1/LRP6/SLC39A5/LPL/TUBB2B/WNT11/SLC39A14/WNT2B/CAPN1/WNT9A/WNT10A/FZD3/ERN1/WNT6/GRM5/APH1A/IL1A	340
KEGG	hsa01524	Platinum drug resistance	69/6806	73/8135	0.004646	0.009698	0.003545	BAD/CASP9/ATP7A/MSH3/BAX/CASP3/MDM2/MAPK1/PIK3CB/BAK1/GSTA3/SLC31A1/PIK3CD/AKT3/ERCC1/POLH/MSH6/GSTO1/FADD/XPA/BID/MAPK3/PIK3CA/GSTT1/FAS/PIK3R2/GSTP1/XIAP/APAF1/MLH1/ATM/MGST3/AKT2/PIK3R1/CASP8/MAP3K5/BRCA1/MSH2/AKT1/MGST1/TOP2B/BBC3/CDKN2A/BIRC2/ERBB2/ABCC2/CYCS/FASLG/TOP2A/PDPK1/GSTO2/TP53/GSTT2/GSTM4/BCL2L1/CDKN1A/GSTM3/GSTM1/PIK3R3/BCL2/MGST2/GSTA4/GSTM5/PMAIP1/GSTM2/BIRC3/REV3L/BIRC5/ATP7B	69
KEGG	hsa00020	Citrate cycle (TCA cycle)	30/6806	30/8135	0.004693	0.009737	0.00356	ACLY/SDHB/PDHA2/DLD/SUCLG1/IDH3G/ACO2/SDHA/MDH2/PCK1/MDH1/SDHC/OGDHL/PC/IDH3B/FH/DLST/CS/OGDH/PDHA1/IDH3A/IDH2/PDHB/PCK2/SDHD/SUCLA2/IDH1/DLAT/SUCLG2/ACO1	30
KEGG	hsa05217	Basal cell carcinoma	60/6806	63/8135	0.004929	0.01016	0.003715	WNT2/FZD10/WNT9B/WNT3/FZD2/GLI2/GLI3/BAX/WNT7A/GADD45B/WNT8B/BAK1/APC2/WNT16/WNT7B/SUFU/DVL2/FZD1/HHIP/WNT1/SHH/WNT8A/FZD9/GSK3B/TCF7/WNT10B/DDB2/POLK/DVL3/KIF7/WNT4/DVL1/CTNNB1/TP53/PTCH2/GADD45A/CDKN1A/AXIN1/PTCH1/GLI1/WNT5B/LEF1/FZD5/GADD45G/TCF7L2/WNT5A/FZD6/APC/FZD7/FZD8/AXIN2/BMP4/FZD4/TCF7L1/WNT11/WNT2B/WNT9A/WNT10A/FZD3/WNT6	60
KEGG	hsa04514	Cell adhesion molecules	136/6806	149/8135	0.004968	0.01018	0.003722	CDH5/NCAM2/HLA-E/CD40/CADM3/ITGB2/CD276/CD4/CLDN3/CDH2/CADM1/ALCAM/CD99/ITGAL/ICAM3/LRRC4/SELPLG/HLA-DRA/HLA-C/CD226/CLDN1/ITGA4/GLG1/NFASC/CD99L2/ITGAM/CLDN19/HLA-B/CDH4/CDH3/CLDN23/CD34/CD58/VCAN/HLA-A/PVR/CLDN5/CLDN2/CLDN15/ITGA9/NRCAM/CDH15/ICAM2/PDCD1/NLGN3/CD2/ESAM/NLGN2/JAM2/SDC2/MAG/NRXN3/PTPRM/CNTNAP2/CLDN4/CLDN8/PECAM1/HLA-DMA/VTCN1/SELE/ICAM1/SELP/PTPRC/CLDN9/HLA-G/SPN/CD6/HLA-F/F11R/ITGB7/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/ITGB1/NRXN1/NRXN2/JAM3/CLDN11/NLGN4Y/CD86/HLA-DRB3/HLA-DRB5/ICOS/TIGIT/SDC1/MPZ/HLA-DOA/CLDN7/NLGN1/PTPRF/CNTN2/ITGAV/NLGN4X/ITGA8/NTNG2/CTLA4/HLA-DPA1/MADCAM1/CLDN6/ITGB8/CD8B/CD40LG/CD28/IGSF11/SDC3/HLA-DPB1/VCAM1/NEGR1/CD80/CLDN16/SDC4/SELL/ICOSLG/LRRC4C/HLA-DOB/HLA-DQA1/HLA-DQA2/NCAM1/L1CAM/MPZL1/CD274/CLDN18/CDH1/CNTN1/CD22/PDCD1LG2/CD8A/CLDN14/CNTNAP1/NEO1/LRRC4B/OCLN/ITGA6/CLDN10/CLDN20	136
KEGG	hsa05231	Choline metabolism in cancer	91/6806	98/8135	0.005767	0.01174	0.004294	SLC5A7/GRB2/RAC1/MAP2K2/PLA2G4D/PRKCB/TSC2/TSC1/SLC22A2/MAPK1/RALGDS/PIK3CB/PDGFRB/RHEB/SLC44A1/PIK3CD/AKT3/WAS/SLC44A2/HRAS/RAF1/RPS6KB2/EIF4EBP1/GPCPD1/RAC2/PLD1/MTOR/PLA2G4C/DGKD/MAPK3/PIK3CA/PLD2/JMJD7-PLA2G4B/PLA2G4B/PIP5K1C/PIK3R2/WASF3/FOS/MAPK9/PDGFD/DGKQ/AKT2/PIK3R1/PLA2G4F/SOS1/PDGFC/DGKE/JUN/AKT1/LYPLA1/SOS2/NRAS/PDGFB/PIP5K1A/SLC22A4/DGKI/PCYT1A/DGKA/SLC22A1/KRAS/PCYT1B/RPS6KB1/DGKZ/PIP5K1B/HIF1A/PDPK1/CHPT1/CHKB/WASF2/MAPK8/EGF/PLA2G4A/PRKCG/DGKG/SLC22A3/PRKCA/PLCG1/MAPK10/CHKA/PIK3R3/SLC44A4/PDGFA/DGKB/MAP2K1/SLC22A5/SP1/SLC44A3/PDGFRA/WASF1/RAC3/EGFR	91
KEGG	hsa04216	Ferroptosis	40/6806	41/8135	0.005918	0.01198	0.004379	PCBP1/FTH1/SLC11A2/VDAC2/ATG5/PRNP/PCBP2/GCLM/LPCAT3/MAP1LC3A/MAP1LC3B/FTL/ACSL3/MAP1LC3C/SAT1/ACSL4/GSS/GPX4/STEAP3/ACSL1/CYBB/NCOA4/SLC39A8/CP/MAP1LC3B2/TF/SAT2/VDAC3/SLC3A2/HMOX1/ATG7/SLC40A1/ACSL5/TFRC/TP53/ACSL6/ALOX15/GCLC/SLC39A14/SLC7A11	40
KEGG	hsa04540	Gap junction	82/6806	88/8135	0.006716	0.01351	0.00494	HTR2C/TUBA1C/GNAQ/GRB2/PRKG2/MAP2K5/MAP2K2/TUBA1B/PLCB2/ADCY8/GNAI1/PRKCB/TUBA1A/MAPK1/TUBA4A/MAPK7/PDGFRB/PRKACA/HTR2A/HRAS/RAF1/ITPR3/GNA11/HTR2B/CSNK1D/MAPK3/TUBA3D/TUBA3E/TUBAL3/TUBB1/PDGFD/CDK1/TUBB/LPAR1/GNAI2/ADCY6/TUBA3C/GUCY1A2/SOS1/PDGFC/GNAI3/GNAS/TUBA8/PLCB4/SOS2/NRAS/ITPR1/PDGFB/ITPR2/ADCY9/ADCY4/DRD1/TUBB6/KRAS/PLCB3/GJD2/PRKACB/PRKACG/MAP3K2/TUBB3/EGF/PLCB1/PRKCG/ADCY7/PRKCA/SRC/PDGFA/DRD2/PRKG1/ADCY5/ADRB1/MAP2K1/GRM1/ADCY3/GJA1/PDGFRA/ADCY1/TJP1/TUBB2B/EGFR/ADCY2/GRM5	82
KEGG	hsa04622	RIG-I-like receptor signaling pathway	66/6806	70/8135	0.006805	0.01361	0.004976	IFNA2/IFNB1/IFNA1/IFNA13/IL12A/IFNE/OTUD5/NFKBIB/MAPK14/ATG5/TANK/IKBKG/TBK1/TBKBP1/FADD/TRAF3/MAVS/NFKBIA/RIPK1/CYLD/MAP3K7/IRF3/NFKB1/MAPK12/TRAF6/ATG12/RNF125/SIKE1/TNF/MAPK13/MAPK9/IKBKB/TRADD/TRAF2/IFNA8/CASP8/DDX3X/NLRX1/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/MAPK11/IL12B/CHUK/CASP10/IKBKE/PIN1/MAPK8/RELA/DDX58/AZI2/IFNA17/DHX58/MAPK10/IFIH1/IRF7/IFNW1/TRIM25/MAP3K1/ISG15/IFNK	66
KEGG	hsa05033	Nicotine addiction	39/6806	40/8135	0.006925	0.01377	0.005033	GABRA6/GABRE/SLC17A8/GABRA4/GABRR1/SLC17A7/GABRA2/GABRG2/SLC32A1/GABRB1/CHRNA4/GRIA2/GABRP/CHRNB2/CHRNA7/GABRA1/GRIN2D/GRIN2C/GRIN2B/GABRA3/GABRR2/GRIN3B/SLC17A6/GABRG1/GRIN2A/GRIN3A/GRIN1/GABRG3/GABRB3/CHRNA6/GABRD/GRIA1/GRIA4/CACNA1B/GABRR3/GRIA3/CACNA1A/GABRA5/GABRB2	39
KEGG	hsa04064	NF-kappa B signaling pathway	96/6806	104/8135	0.007546	0.01486	0.005432	EDARADD/CD40/UBE2I/BTK/CSNK2B/LTB/TICAM1/IL1B/LTBR/PRKCB/EDA/GADD45B/CD14/IRAK1/CFLAR/SYK/BCL2A1/IKBKG/MYD88/CARD11/CSNK2A2/PTGS2/TRAF3/TNFRSF1A/RELB/NFKBIA/RIPK1/CCL4/IRAK4/CYLD/MAP3K7/TNFAIP3/CSNK2A1/PLCG2/NFKB1/TRAF6/PIAS4/XIAP/NFKB2/CCL19/TNF/IKBKB/PARP1/TRADD/TRAF2/ATM/TAB2/LYN/MALT1/TAB1/CXCL1/PRKCQ/TNFSF14/ICAM1/TIRAP/CCL21/PLAU/BIRC2/CHUK/EDA2R/LAT/CXCL3/TAB3/IL1R1/LCK/MAP3K14/LTA/CARD10/ZAP70/TRAF1/LY96/CARD14/GADD45A/CCL13/ERC1/BCL2L1/RELA/DDX58/PLCG1/TLR4/EDAR/CD40LG/GADD45G/VCAM1/TRAF5/TNFSF13B/BCL2/TRIM25/TICAM2/BLNK/CXCL12/BCL10/BIRC3/TNFRSF11A/LBP/CXCL2	96
KEGG	hsa00510	N-Glycan biosynthesis	48/6806	50/8135	0.007563	0.01486	0.005432	MGAT4C/MGAT4B/B4GALT1/ALG12/ALG10B/ALG2/DOLK/GANAB/ALG3/RPN2/B4GALT2/B4GALT3/DPAGT1/TUSC3/FUT8/DAD1/ALG5/ALG6/MGAT5B/MGAT3/ALG14/STT3B/MAN1A1/MAN1B1/RPN1/DPM1/MOGS/MAN2A2/MGAT4A/MGAT1/STT3A/DPM2/MGAT5/ALG9/DDOST/ST6GAL2/DOLPP1/DPM3/SRD5A3/MGAT2/ALG13/MAN1C1/ST6GAL1/ALG1/MAN2A1/ALG10/ALG8/MAN1A2	48
KEGG	hsa05211	Renal cell carcinoma	65/6806	69/8135	0.007718	0.01507	0.005511	BAD/GRB2/TGFB1/RAC1/MAP2K2/TGFB2/CRKL/PAK1/PAK2/MAPK1/PIK3CB/ARAF/EGLN2/FLCN/PIK3CD/AKT3/HRAS/CUL2/RAF1/EP300/MAPK3/PIK3CA/PIK3R2/CDC42/TFE3/EGLN3/EGLN1/EPAS1/FH/AKT2/PIK3R1/RAP1B/RAP1A/SOS1/JUN/AKT1/ARNT2/SOS2/NRAS/HGF/PRCC/PDGFB/RAPGEF1/CRK/VEGFA/ARNT/TGFA/KRAS/RBX1/PAK4/HIF1A/BRAF/CDKN1A/SLC2A1/ETS1/PAK3/PIK3R3/PTPN11/PAK6/CREBBP/MAP2K1/TGFB3/GAB1/MET/VHL	65
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	27/6806	27/8135	0.008031	0.0155	0.005668	B3GNT4/B4GALT1/FUT2/B3GALT1/B3GNT3/B4GALT2/A4GALT/B4GALT3/FUT3/FUT7/FUT1/B4GALT4/FUT9/ST3GAL6/ST3GAL4/B3GNT2/ST3GAL3/FUT4/B3GNT5/FUT5/FUT6/B3GALNT1/B3GALT5/GCNT2/B3GALT2/ST8SIA1/ABO	27
KEGG	hsa04966	Collecting duct acid secretion	27/6806	27/8135	0.008031	0.0155	0.005668	ATP6V0D1/ATP6V1E2/ATP6V0A1/ATP6V1F/ATP6V1E1/ATP4B/ATP6V1G1/TCIRG1/ATP6V1B2/SLC12A7/ATP6V1B1/ATP6V0A2/ATP6V1A/ATP6V0E2/ATP6V0D2/ATP6V1D/ATP6V0C/ATP6V1C1/ATP6V0E1/ATP6V1G3/SLC4A1/CLCNKB/CA2/ATP6V1G2/ATP6V0A4/ATP4A/ATP6V1C2	27
KEGG	hsa04974	Protein digestion and absorption	95/6806	103/8135	0.008387	0.0161	0.005885	CPB2/COL6A6/COL15A1/COL21A1/CELA2A/PRCP/ELN/COL7A1/CPB1/SLC3A1/KCNE3/KCNQ1/COL13A1/SLC7A8/ATP1B3/SLC36A4/SLC15A1/COL6A1/COL9A3/MME/COL8A1/COL16A1/PGA3/PGA4/PGA5/COL18A1/COL9A1/SLC36A1/COL11A1/SLC8A1/COL4A3/COL28A1/COL11A2/CPA3/COL23A1/SLC3A2/COL4A2/SLC1A1/CTRL/SLC8A3/ATP1A1/COL6A3/SLC9A3/COL4A5/KCNN4/XPNPEP2/COL4A6/FXYD2/COL27A1/SLC1A5/COL9A2/CELA2B/SLC7A7/SLC6A19/COL1A1/SLC38A2/COL12A1/COL22A1/COL19A1/KCNJ13/CTRB1/CTRB2/COL25A1/ATP1B1/ACE2/CELA3B/COL14A1/CPA2/COL8A2/COL4A1/COL24A1/MEP1B/ATP1A4/ATP1A2/COL5A2/ATP1A3/COL2A1/ATP1B4/COL5A3/SLC7A9/PRSS2/PRSS3/COL4A4/CPA1/DPP4/COL3A1/MEP1A/COL20A1/KCNK5/COL5A1/SLC16A10/COL17A1/COL6A2/COL1A2/SLC8A2	95
KEGG	hsa05030	Cocaine addiction	47/6806	49/8135	0.008723	0.0165	0.006034	CREB3/ATF4/GNAI1/GRIA2/GPSM1/ATF6B/PRKACA/RGS9/DLG4/NFKB1/CDK5/GNAI2/GRM3/GNAI3/GNAS/JUN/GRM2/GRIN2D/CREB3L4/DRD1/MAOA/BDNF/CREB3L2/PRKACB/PRKACG/GRIN2C/GRIN2B/CREB5/CREB3L1/TH/RELA/GRIN3B/ATF2/CREB1/GRIN2A/GRIN3A/GRIN1/CDK5R1/SLC18A2/SLC18A1/DRD2/FOSB/PPP1R1B/ADCY5/MAOB/SLC6A3/CREB3L3	47
KEGG	hsa04071	Sphingolipid signaling pathway	109/6806	119/8135	0.008744	0.0165	0.006034	SMPD2/GNAQ/PPP2CA/PPP2R5D/PPP2R5C/GNA13/PPP2R2D/RAC1/MAP2K2/FYN/RHOA/PLCB2/MAPK14/PPP2R2C/ASAH2/BAX/GNAI1/PRKCB/MAPK1/PIK3CB/SPTLC3/ABCC1/PPP2R2A/PIK3CD/AKT3/HRAS/RAF1/TNFRSF1A/RAC2/PPP2R1A/S1PR4/PLD1/ROCK1/BID/MAPK3/PIK3CA/SMPD1/PLD2/NFKB1/MAPK12/PTEN/PIK3R2/ROCK2/SPTLC1/PPP2R5B/TNF/MAPK13/MAPK9/SGMS1/SGPL1/ADORA3/TRADD/NOS3/TRAF2/AKT2/PIK3R1/NSMAF/GNAI2/MAP3K5/FCER1G/DEGS1/SPTLC2/GNAI3/CTSD/PRKCZ/PLCB4/AKT1/NRAS/ADORA1/PPP2R3C/GAB2/PPP2R5A/MAPK11/PPP2R5E/PPP2R3A/PPP2R2B/KRAS/PLCB3/KNG1/PPP2R3B/S1PR3/PDPK1/FCER1A/PPP2CB/SPHK2/TP53/MAPK8/PLCB1/PRKCG/SGMS2/RELA/GNA12/PRKCA/S1PR5/DEGS2/OPRD1/SPHK1/MAPK10/PIK3R3/S1PR2/SGPP1/BCL2/S1PR1/PRKCE/ASAH1/MAP2K1/SGPP2/ACER1/RAC3	109
KEGG	hsa04664	Fc epsilon RI signaling pathway	64/6806	68/8135	0.008746	0.0165	0.006034	GRB2/VAV1/RAC1/BTK/LCP2/MAP2K2/FYN/MAPK14/PLA2G4D/MAPK1/PIK3CB/SYK/INPP5D/PIK3CD/AKT3/HRAS/RAF1/RAC2/PLA2G4C/PLCG2/MAPK3/PIK3CA/MAPK12/JMJD7-PLA2G4B/PLA2G4B/MAP2K4/PIK3R2/TNF/MAPK13/MAPK9/IL4/AKT2/PIK3R1/PLA2G4F/CSF2/LYN/MAP2K6/FCER1G/SOS1/AKT1/VAV2/SOS2/NRAS/ALOX5AP/GAB2/MAPK11/IL3/LAT/KRAS/PDPK1/FCER1A/ALOX5/MAP2K7/MAPK8/IL13/PLA2G4A/PRKCA/PLCG1/MAPK10/PIK3R3/MAP2K3/MAP2K1/VAV3/RAC3	64
KEGG	hsa04350	TGF-beta signaling pathway	87/6806	94/8135	0.008958	0.01681	0.006145	PITX2/GREM1/RGMA/PPP2CA/SMURF2/TGFB1/TGFB2/RHOA/ID3/TGIF1/MAPK1/BMP8A/AMH/ACVR2B/RPS6KB2/SMURF1/EP300/ZFYVE16/PPP2R1A/SMAD9/ROCK1/SMAD4/MAPK3/ZFYVE9/SMAD3/ID2/TNF/E2F4/ACVR1B/SMAD1/TGFBR2/CHRD/BMP7/BMP6/NBL1/BAMBI/SMAD2/INHBB/CUL1/SMAD6/TGIF2/ACVR1/MYC/THBS1/SMAD5/GREM2/FST/AMHR2/LEFTY2/CDKN2B/GDF5/IFNG/LTBP1/RPS6KB1/RBX1/INHBE/BMPR1A/PPP2CB/SKP1/HAMP/BMPR1B/BMP8B/TFDP1/TGFBR1/ACVR2A/RGMB/THSD4/BMP5/E2F5/BMPR2/SMAD7/NODAL/INHBC/CREBBP/ACVR1C/LEFTY1/RBL1/BMP4/SP1/NEO1/TGFB3/FMOD/ID1/DCN/FBN1/ID4/NOG	87
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	26/6806	26/8135	0.009605	0.01792	0.006552	PIGT/PIGS/PIGN/PIGY/PIGF/MPPE1/PIGQ/PIGP/PIGK/PIGH/GPAA1/PIGV/PIGA/PGAP1/PIGB/PIGG/DPM2/PIGU/PIGX/GPLD1/PIGM/PIGC/PIGO/PIGW/PIGL/PIGZ	26
KEGG	hsa00010	Glycolysis / Gluconeogenesis	63/6806	67/8135	0.009904	0.01838	0.006718	LDHAL6B/ALDOB/ADH1B/ADH7/PGAM1/PGK1/GAPDH/AKR1A1/TPI1/ALDOA/PDHA2/DLD/ADH5/ENO3/PGK2/ADH1A/ENO1/FBP1/HK3/PGAM2/ALDH9A1/ALDH2/PGM1/GPI/PCK1/G6PC/PFKP/GCK/ACSS2/PFKM/G6PC3/ENO2/ALDH1B1/PDHA1/ALDH3A2/HK2/HKDC1/PDHB/GALM/ALDOC/PGM2/G6PC2/ALDH7A1/LDHB/PCK2/MINPP1/PKLR/ALDH3B1/LDHAL6A/DLAT/ADPGK/LDHA/PFKL/GAPDHS/HK1/ALDH3B2/ADH4/ALDH3A1/BPGM/FBP2/ADH1C/LDHC/ADH6	63
KEGG	hsa04918	Thyroid hormone synthesis	70/6806	75/8135	0.01102	0.0202	0.007383	IYD/GPX5/TTF1/CREB3/GNAQ/HSPA5/ATF4/HSP90B1/PLCB2/ADCY8/PRKCB/ATF6B/PRKACA/ITPR3/SERPINA7/ATP1B3/ASGR2/PDIA4/ADCY6/TTR/GNAS/PLCB4/GSR/GPX7/DUOX1/ITPR1/CGA/ITPR2/ADCY9/ADCY4/CREB3L4/PAX8/ATP1A1/GPX2/CREB3L2/PLCB3/DUOXA2/PRKACB/PRKACG/FXYD2/CREB5/CREB3L1/CANX/PLCB1/PRKCG/ADCY7/ATF2/PRKCA/CREB1/SLC26A4/ASGR1/ATP1B1/GPX1/TSHB/ATP1A4/ADCY5/ATP1A2/TTF2/ATP1A3/ATP1B4/GPX8/ADCY3/TPO/ADCY1/LRP2/CREB3L3/ALB/DUOX2/ADCY2/GPX3	70
KEGG	hsa01250	Biosynthesis of nucleotide sugars	36/6806	37/8135	0.01107	0.0202	0.007383	MPI/UGP2/PMM1/GMDS/HK3/NANS/GMPPB/PGM1/GPI/GALK1/GALE/GFPT2/GMPPA/GALK2/CMAS/GCK/NANP/PGM3/TSTA3/PMM2/TGDS/NAGK/FPGT/HK2/HKDC1/GNPNAT1/PGM2/GALT/MIOX/HK1/GFPT1/UXS1/UAP1/GNE/UAP1L1/UGDH	36
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	36/6806	37/8135	0.01107	0.0202	0.007383	IGF1/PRKCB/MAPK1/PIK3CB/PIK3CD/MAPK3/PIK3CA/ATP1B3/PIK3R2/SCNN1B/PIK3R1/SFN/SCNN1A/KCNJ1/IRS1/ATP1A1/SGK1/KRAS/FXYD2/PDPK1/INS/INSR/PRKCG/NR3C2/PRKCA/SCNN1G/PIK3R3/ATP1B1/ATP1A4/ATP1A2/ATP1A3/ATP1B4/HSD11B2/NEDD4L/FXYD4/SLC9A3R2	36
KEGG	hsa00620	Pyruvate metabolism	45/6806	47/8135	0.01158	0.02102	0.007684	LDHAL6B/ADH1B/ADH7/ACOT12/AKR1A1/PDHA2/DLD/ADH5/ADH1A/ALDH9A1/ALDH2/ME2/MDH2/PCK1/MDH1/ACYP2/GLO1/GRHPR/ACSS2/PC/FH/ALDH1B1/PDHA1/ALDH3A2/HAGH/PDHB/ALDH7A1/LDHB/ACYP1/ACAT2/PCK2/ACAT1/PKLR/LDHAL6A/DLAT/LDHA/ACACA/ME3/ADH4/ACACB/ADH1C/LDHC/ADH6/LDHD/ME1	45
KEGG	hsa04923	Regulation of lipolysis in adipocytes	53/6806	56/8135	0.0125	0.02257	0.00825	AQP7/NPY1R/PRKG2/NPPA/ADCY8/GNAI1/PIK3CB/PNPLA2/PTGS1/PIK3CD/PRKACA/AKT3/PTGS2/ABHD5/PIK3CA/MGLL/PIK3R2/NPR1/PLIN1/IRS2/AKT2/PIK3R1/GNAI2/ADCY6/GNAI3/GNAS/AKT1/ADORA1/CGA/ADCY9/IRS4/ADCY4/IRS1/PRKACB/PRKACG/PTGER3/ADRB2/INS/PDE3B/INSR/ADCY7/PIK3R3/TSHB/PRKG1/ADCY5/FABP4/ADRB1/ADCY3/ADRB3/ADCY1/NPY/ADCY2/LIPE	53
KEGG	hsa04726	Serotonergic synapse	105/6806	115/8135	0.0129	0.02308	0.008437	GNG13/TPH2/HTR1D/HTR2C/KCND2/CYP4X1/KCNN2/GNAQ/GABRB1/GNB1/KCNJ6/GNG2/CYP2C19/GNG5/PLCB2/GNB2/CACNA1C/PLA2G4D/GNAI1/CASP3/PRKCB/MAPK1/ARAF/HTR6/CACNA1S/PTGS1/PRKACA/HTR2A/PTGS2/HRAS/DUSP1/RAF1/ITPR3/CYP2D6/HTR2B/GNGT2/PLA2G4C/MAPK3/JMJD7-PLA2G4B/PLA2G4B/GNG3/GNG8/KCNJ5/GNG7/GNG10/HTR7/APP/PLA2G4F/CACNA1F/GNAI2/CYP2C18/GNAI3/GNAS/GNB3/PLCB4/HTR5A/NRAS/ITPR1/GNAO1/ALOX12B/GNG11/HTR1F/ALOX12/GNG12/CYP2J2/GNB5/ITPR2/CYP2C9/HTR3C/MAOA/CYP2C8/KRAS/PLCB3/PRKACB/PRKACG/BRAF/CACNA1D/ALOX5/HTR3B/HTR1A/PLCB1/PLA2G4A/PRKCG/GNGT1/KCNJ3/PRKCA/HTR1B/ALOX15/HTR1E/GABRB3/SLC18A2/GNB4/SLC18A1/RAPGEF3/CACNA1B/GNG4/ADCY5/CACNA1A/MAP2K1/MAOB/TRPC1/GABRB2/SLC6A4/KCNJ9/HTR3A	105
KEGG	hsa00350	Tyrosine metabolism	35/6806	36/8135	0.01292	0.02308	0.008437	ADH1B/ADH7/AOX1/ADH5/ADH1A/COMT/MIF/DBH/AOC2/GOT1/GOT1L1/AOC3/HGD/TYRP1/FAH/GOT2/MAOA/GSTZ1/ALDH3B1/PNMT/LRTOMT/TH/ALDH3B2/IL4I1/ADH4/ALDH3A1/FAHD1/DCT/ADH1C/MAOB/HPD/TYR/TPO/TAT/ADH6	35
KEGG	hsa04930	Type II diabetes mellitus	44/6806	46/8135	0.01333	0.02367	0.008655	ADIPOQ/SLC2A2/KCNJ11/CACNA1C/MAPK1/PIK3CB/HK3/PIK3CD/MTOR/PRKCD/MAPK3/PIK3CA/PIK3R2/GCK/TNF/MAPK9/IKBKB/IRS2/ABCC8/PIK3R1/PRKCZ/HK2/HKDC1/IRS4/IRS1/PKLR/SOCS4/INS/CACNA1D/MAPK8/PDX1/HK1/INSR/SOCS3/CACNA1G/MAPK10/PIK3R3/CACNA1E/PRKCE/SOCS1/CACNA1B/CACNA1A/SLC2A4/SOCS2	44
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	24/6806	24/8135	0.01374	0.02428	0.008876	HS3ST3A1/HS3ST2/HS6ST2/HS3ST5/HS6ST3/XYLT2/B4GALT7/EXT1/NDST2/NDST4/B3GAT3/EXTL1/HS6ST1/EXT2/NDST1/EXTL3/B3GALT6/NDST3/HS3ST3B1/HS2ST1/GLCE/XYLT1/HS3ST1/EXTL2	24
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	90/6806	98/8135	0.01407	0.02473	0.009042	HTR2C/IGF1/GNAQ/CAMK2G/CALML6/PLCB2/MAPK14/ADCY8/PLA2G4D/IL1B/PRKCB/PIK3CB/HRH1/PIK3CD/PRKACA/HTR2A/PPP1CA/PLA2G6/TRPV3/CALM1/ITPR3/HTR2B/PLA2G4C/PLCG2/PRKCD/PIK3CA/TRPV2/MAPK12/JMJD7-PLA2G4B/PLA2G4B/PPP1CB/PRKCH/CALML4/PIK3R2/MAPK13/MAPK9/PTGER2/PPP1CC/PIK3R1/PLA2G4F/CALML5/ADCY6/MAP2K6/NTRK1/PTGER4/GNAS/PLCB4/PRKCQ/F2RL1/ITPR1/CAMK2A/TRPA1/ALOX12/CALML3/CYP2J2/MAPK11/ITPR2/ADCY9/ADCY4/P2RY2/CAMK2B/IL1R1/IL1RAP/PLCB3/KNG1/PRKACB/PRKACG/CAMK2D/MAPK8/TRPV1/CALM2/PLCB1/PLA2G4A/PRKCG/ADCY7/PRKCA/PLCG1/CALM3/SRC/MAPK10/PIK3R3/PRKCE/MAP2K3/BDKRB1/ADCY5/TRPV4/ADCY3/ADCY1/TRPM8/ADCY2	90
KEGG	hsa05150	Staphylococcus aureus infection	88/6806	96/8135	0.01722	0.03011	0.01101	KRT13/MBL2/KRT12/KRT20/KRT27/ITGB2/PTAFR/C1R/KRT34/KRT32/KRT33B/ITGAL/FCGR2A/KRT24/SELPLG/HLA-DRA/DEFB103A/DEFB103B/ITGAM/C2/CFI/KRT19/C3/C5AR1/PLG/FPR1/FCGR2C/C1QB/KRT38/KRT25/CAMP/HLA-DMA/C1QA/KRT23/ICAM1/CFD/SELP/CFB/KRT36/FCAR/C3AR1/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL10/HLA-DRB3/HLA-DRB5/KRT18/DSG1/KRT35/FCGR1A/HLA-DOA/FCGR3B/FCGR3A/DEFA5/C5/C1S/MASP2/CFH/KRT40/HLA-DPA1/KRT15/FCGR2B/DEFA1/DEFA1B/DEFA3/FPR2/HLA-DPB1/KRT14/KRT16/KRT37/DEFB4A/DEFA6/HLA-DOB/HLA-DQA1/HLA-DQA2/C4A/C4B/DEFA4/KRT9/FPR3/MASP1/KRT31/C1QC/FGG/KRT10/KRT17	88
KEGG	hsa03020	RNA polymerase	33/6806	34/8135	0.01759	0.03059	0.01118	POLR2E/POLR2G/POLR2B/POLR2J/POLR3H/POLR3C/POLR2A/ZNRD1/POLR2I/POLR3E/POLR2K/POLR2F/POLR1E/POLR2C/POLR3F/POLR2H/POLR2L/POLR3K/POLR3D/TWISTNB/POLR1C/POLR1D/POLR1B/POLR2J3/POLR2J2/POLR3B/POLR3GL/POLR2D/POLR3G/POLR3A/POLR1A/CRCP/CD3EAP	33
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	50/6806	53/8135	0.01841	0.03186	0.01165	PTH/GNAQ/PLCB2/AP2M1/PRKCB/RAB11A/CALB1/CLTA/VDR/PRKACA/ATP2B3/CLTC/CLTB/TRPV5/ATP1B3/AP2S1/ATP2B2/KLK1/AP2B1/CLTCL1/ATP2B1/DNM2/ATP2B4/AP2A2/ADCY6/GNAS/PLCB4/DNM1/SLC8A1/ADCY9/SLC8A3/ATP1A1/KLK2/PLCB3/PRKACB/AP2A1/PRKACG/FXYD2/PLCB1/PRKCG/PRKCA/ESR1/ATP1B1/KL/ATP1A4/ATP1A2/ATP1A3/ATP1B4/PTH1R/SLC8A2	50
KEGG	hsa00900	Terpenoid backbone biosynthesis	22/6806	22/8135	0.01965	0.03383	0.01237	FDPS/FNTA/MVD/GGPS1/IDI1/PMVK/HMGCR/PDSS1/RCE1/HMGCS1/ICMT/NUS1/HMGCS2/PDSS2/ZMPSTE24/ACAT2/MVK/ACAT1/FNTB/PCYOX1/DHDDS/IDI2	22
KEGG	hsa04110	Cell cycle	114/6806	126/8135	0.01976	0.03384	0.01237	CCNB3/ZBTB17/CCND1/TGFB1/TGFB2/ANAPC10/HDAC2/MCM7/CDK7/MDM2/CCNH/GADD45B/HDAC1/ANAPC2/ANAPC7/PTTG2/ANAPC1/TTK/E2F1/EP300/SMC3/MCM5/SMAD4/CDC14A/ANAPC16/CDKN2D/SMAD3/CDK2/PKMYT1/E2F4/MAD1L1/ANAPC5/PTTG1/CDK1/YWHAQ/ATM/RAD21/SMC1B/ANAPC13/CDC27/CCND3/YWHAE/SKP2/CHEK2/SFN/YWHAZ/CDKN1B/PCNA/CDKN2C/ANAPC4/FZR1/SMAD2/CDC26/PRKDC/YWHAH/GSK3B/YWHAG/CDC25B/SMC1A/CUL1/MCM2/MYC/ANAPC11/MCM3/ABL1/STAG2/YWHAB/CDKN2A/CCND2/CDK4/MAD2L2/TFDP2/CDKN2B/RBX1/ATR/RB1/BUB1/CDC7/SKP1/CDK6/TP53/E2F3/CDC16/GADD45A/CCNA2/BUB1B/DBF4/RBL2/MCM6/CDKN1A/CDC25C/TFDP1/CCNE1/CCNE2/GADD45G/STAG1/CCNB2/CDC6/E2F5/CDC14B/CREBBP/CDC23/BUB3/RBL1/MCM4/CDC45/CDKN1C/TGFB3/CCNB1/PLK1/CCNA1/ESPL1/CDC25A/CHEK1	114
KEGG	hsa00071	Fatty acid degradation	41/6806	43/8135	0.02022	0.03445	0.01259	ADH1B/ADH7/ACAA1/HADHA/HADHB/CPT1C/ADH5/HADH/ACADVL/ADH1A/CPT1A/ALDH9A1/ECHS1/ACAA2/ACADS/ALDH2/ACSBG2/CPT2/ACSL3/ACADSB/ACADL/ACSL4/GCDH/ACOX1/ACSL1/ALDH1B1/ALDH3A2/ALDH7A1/ACAT2/ACAT1/ACSBG1/ACSL5/ACSL6/CPT1B/ADH4/ACOX3/ACADM/ADH1C/CYP2U1/EHHADH/ADH6	41
KEGG	hsa00770	Pantothenate and CoA biosynthesis	21/6806	21/8135	0.0235	0.03984	0.01456	PPCS/COASY/ALDH2/PPCDC/VNN2/PANK2/ALDH1B1/UPB1/ALDH3A2/CSAD/ENPP3/BCAT1/VNN1/PANK3/BCAT2/DPYS/DPYD/AASDHPPT/GADL1/PANK1/ENPP1	21
KEGG	hsa03013	Nucleocytoplasmic transport	98/6806	108/8135	0.02479	0.04181	0.01529	UBE2I/UPF1/SEC13/CASC3/RAN/NXF1/RAE1/AHCTF1/SAP18/IPO4/ACIN1/TNPO2/XPO6/RNPS1/KPNA6/NCBP1/UPF2/NUP153/NUP62/CSE1L/DDX19A/DDX19B/POM121/POM121C/NUP214/NUP205/IPO8/NUP98/EIF4A3/NUP93/IPO13/THOC2/NUP50/NUP85/EEF1A1/TNPO3/RANBP17/NUP133/NXT2/SENP2/NUP37/THOC6/THOC1/EEF1A2/NUP88/XPOT/THOC5/PNN/MAGOH/RANGAP1/TPR/XPO5/SUMO3/MAGOHB/SRRM1/UPF3A/NXF2/NXF2B/SUMO1/RANBP2/TMEM33/IPO9/NUP188/IPO7/XPO7/NUP155/KPNB1/KPNA1/SNUPN/THOC7/NUP160/THOC3/NXT1/XPO4/PHAX/NUP54/NUP35/RBM8A/SUMO4/NUP210/XPO1/IPO11/IPO5/KPNA5/GLE1/NCBP2/TNPO1/KPNA4/NMD3/NUP43/KPNA3/KPNA2/NUP107/UPF3B/SEH1L/AAAS/SUMO2/POM121L2	98
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	91/6806	100/8135	0.02525	0.04238	0.01549	IL2/CCL25/TNFRSF14/IL20/IL2RG/CXCL13/TNFRSF1B/IL22RA1/LTBR/TNFRSF10D/TNFRSF10C/IL6R/IL10RA/TNFRSF1A/CSF1R/CCL4/IL2RA/CCL27/IL20RA/CCR2/CXCR3/CCL24/CCL28/CXCR1/CCL19/TNF/IL10RB/IL6ST/CCR1/XCR1/CCR7/CXCR2/CXCL1/CCL5/TNFSF14/IL19/XCL1/XCL2/CX3CR1/IL34/CCL21/IL10/CXCL3/TNFRSF10B/CXCR4/LTA/IL2RB/CCL1/CCL26/IL18RAP/IL20RB/CCL14/CCL15/CCL13/CCL23/PPBP/CCR10/TNFSF10/IL18/IL24/CCL7/CCL18/PF4/CCL20/CXCR5/CCR3/CXCL6/CCL16/CCL17/IL18R1/CXCL14/TNFRSF10A/CCL2/IL6/CCL11/CCR4/CXCL12/CCR9/PF4V1/CXCL11/CCL3/CCL3L1/CCL3L3/CSF1/CCL22/CXCL9/CCL8/CXCL5/CXCL2/CCR6/CCR5	91
KEGG	hsa01200	Carbon metabolism	104/6806	115/8135	0.02641	0.0441	0.01612	ALDOB/HAO1/TKTL2/PGAM1/PGK1/GCSH/PHGDH/SDHB/GAPDH/TPI1/ALDOA/PDHA2/TALDO1/DLD/ADH5/GLUD1/SDS/CAT/SUCLG1/TKT/ENO3/PGK2/ENO1/IDH3G/FBP1/PRPS1L1/HK3/PGAM2/ECHS1/ACADS/GLYCTK/ME2/GPI/ACO2/PGP/SDHA/MDH2/G6PD/MDH1/PRPS2/PCCA/PGD/GLUD2/ESD/PGLS/PFKP/GCK/ACSS2/PFKM/SDHC/OGDHL/ACOX1/MCEE/PC/IDH3B/FH/GOT1/DLST/CS/OGDH/ENO2/GOT1L1/GPT/PDHA1/IDH3A/SHMT2/IDH2/HK2/HKDC1/PDHB/ALDOC/ACAT2/SDHD/ACAT1/GOT2/SUCLA2/PKLR/IDH1/DLAT/ADPGK/RPE/PFKL/RGN/HIBCH/HK1/SHMT1/PRPS1/PCCB/HAO2/ME3/GPT2/AGXT/H6PD/AMT/ACOX3/TKTL1/FBP2/RPIA/SUCLG2/GLDC/SDSL/ACO1/CPS1/ME1	104
KEGG	hsa05219	Bladder cancer	39/6806	41/8135	0.02658	0.04416	0.01615	CCND1/UPK3A/MAP2K2/MDM2/MAPK1/ARAF/HRAS/RAF1/E2F1/RASSF1/MAPK3/DAPK3/DAPK2/NRAS/HBEGF/MYC/THBS1/CDKN2A/CDK4/VEGFA/ERBB2/MMP9/KRAS/RB1/TYMP/BRAF/TP53/E2F3/EGF/CDKN1A/MMP2/SRC/MMP1/DAPK1/RPS6KA5/CDH1/MAP2K1/FGFR3/EGFR	39
KEGG	hsa00052	Galactose metabolism	30/6806	31/8135	0.02778	0.04571	0.01671	SI/B4GALT1/UGP2/GLB1/HK3/GLA/PGM1/B4GALT2/GALK1/GALE/G6PC/GAA/PFKP/GCK/PFKM/AKR1B1/G6PC3/HK2/HKDC1/GALM/PGM2/G6PC2/MGAM/GALT/LALBA/PFKL/HK1/AKR1B10/LCT/GANC	30
KEGG	hsa00410	beta-Alanine metabolism	30/6806	31/8135	0.02778	0.04571	0.01671	CNDP1/HADHA/ALDH9A1/ECHS1/ACADS/ALDH2/ABAT/MLYCD/AOC2/ACOX1/AOC3/ALDH1B1/UPB1/ALDH3A2/ALDH7A1/CSAD/ALDH3B1/HIBCH/CARNS1/SMOX/ALDH3B2/GAD2/CNDP2/DPYS/GAD1/ALDH3A1/ACOX3/DPYD/GADL1/EHHADH	30
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	20/6806	20/8135	0.0281	0.04601	0.01682	CHSY3/CHST3/XYLT2/B4GALT7/CHST13/UST/CHST7/CHPF2/B3GAT3/DSE/CHPF/CHSY1/CHST15/CHST11/CHST14/B3GALT6/CHST12/XYLT1/CSGALNACT1/CSGALNACT2	20
KEGG	hsa01523	Antifolate resistance	29/6806	30/8135	0.03231	0.05263	0.01924	FOLR2/IL1B/ABCC1/IKBKG/SLC19A1/DHFR/NFKB1/TNF/IKBKB/ATIC/MTHFR/SHMT2/ABCC5/ALOX12/ABCC4/CHUK/FOLR1/ABCC2/SLC46A1/GGH/FOLR3/SHMT1/ABCC3/RELA/ABCG2/IL6/TYMS/GART/FPGS	29
KEGG	hsa00531	Glycosaminoglycan degradation	19/6806	19/8135	0.0336	0.05448	0.01992	GALNS/GUSB/HYAL1/HYAL3/GLB1/HEXB/HGSNAT/NAGLU/HYAL4/HEXA/HYAL2/IDUA/IDS/SGSH/SPAM1/HPSE2/GNS/HPSE/ARSB	19
KEGG	hsa04744	Phototransduction	28/6806	29/8135	0.03753	0.06056	0.02214	GRK7/PDE6A/PDE6G/GNB1/CALML6/GUCA1A/SAG/CNGA1/GUCY2D/GUCA1B/GNAT1/RGS9/CALM1/CALML4/CALML5/CALML3/CNGB1/CALM2/GNGT1/GUCY2F/PDE6B/GRK1/CALM3/GUCA1C/GNAT2/RCVRN/SLC24A1/RHO	28
KEGG	hsa03420	Nucleotide excision repair	44/6806	47/8135	0.03895	0.06224	0.02276	GTF2H1/ERCC3/CDK7/CCNH/XPC/ERCC5/GTF2H5/ERCC1/POLD3/XPA/RPA3/POLE4/CETN2/GTF2H2/GTF2H2C/RFC3/RAD23B/RFC1/POLE3/ERCC6/POLD4/ERCC4/RFC2/DDB1/PCNA/POLD1/CUL4B/MNAT1/POLE/RPA2/LIG1/DDB2/RFC5/CUL4A/RFC4/ERCC8/POLD2/RAD23A/RBX1/RPA1/GTF2H3/ERCC2/POLE2/GTF2H4	44
KEGG	hsa04973	Carbohydrate digestion and absorption	44/6806	47/8135	0.03895	0.06224	0.02276	SI/SLC2A2/TAS1R2/GNAT3/PLCB2/PRKCB/PIK3CB/HK3/PIK3CD/AKT3/SLC2A5/SLC37A4/PIK3CA/ATP1B3/G6PC/PIK3R2/AKT2/PIK3R1/G6PC3/PLCB4/AKT1/AMY1A/AMY1B/AMY1C/AMY2A/HK2/HKDC1/G6PC2/ATP1A1/MGAM/PLCB3/FXYD2/CACNA1D/HK1/PLCB1/PIK3R3/ATP1B1/LCT/AMY2B/ATP1A4/SLC5A1/ATP1A2/ATP1A3/ATP1B4	44
KEGG	hsa05330	Allograft rejection	36/6806	38/8135	0.03978	0.06326	0.02313	IL2/IL12A/HLA-E/CD40/HLA-DRA/HLA-C/HLA-B/HLA-A/FAS/TNF/IL4/HLA-DMA/GZMB/HLA-G/HLA-F/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL10/IFNG/CD86/HLA-DRB3/HLA-DRB5/PRF1/FASLG/HLA-DOA/HLA-DPA1/CD40LG/CD28/HLA-DPB1/CD80/HLA-DOB/HLA-DQA1/HLA-DQA2	36
KEGG	hsa03018	RNA degradation	72/6806	79/8135	0.04185	0.06625	0.02422	PABPC5/PABPC1L2B/PABPC4L/CNOT1/LSM1/EDC4/LSM2/CNOT10/LSM4/LSM3/ENO3/ENO1/PABPC1/CNOT2/EXOSC1/CNOT4/EXOSC8/SKIV2L/EXOSC4/NUDT16/BTG1/EXOSC10/LSM7/DCP1A/EXOSC3/DHX36/XRN2/PABPC1L/EXOSC5/LSM6/PFKP/PFKM/DCP1B/MPHOSPH6/HSPD1/PARN/ENO2/ZCCHC7/CNOT8/BTG2/PABPC3/PATL1/PAN2/DIS3/EDC3/LSM5/BTG4/DDX6/EXOSC7/CNOT6L/EXOSC2/EXOSC9/WDR61/DIS3L/C1D/TOB1/DCP2/PFKL/CNOT7/EXOSC6/CNOT6/CNOT3/PAN3/DCPS/HSPA9/TTC37/PABPC4/PNPT1/XRN1/PNLDC1/TOB2/BTG3	72
KEGG	hsa04623	Cytosolic DNA-sensing pathway	58/6806	63/8135	0.04217	0.06633	0.02425	IL33/IFNA2/IFNB1/IFNA1/IFNA13/NFKBIB/POLR2E/ADAR/IL1B/POLR3H/POLR3C/IKBKG/TBK1/RIPK3/MAVS/POLR3E/NFKBIA/RIPK1/CCL4/PYCARD/POLR2K/IRF3/NFKB1/POLR2F/IKBKB/POLR3F/IFNA8/POLR2H/POLR2L/CCL5/POLR3K/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/POLR3D/CHUK/IKBKE/POLR1C/AIM2/TREX1/CASP1/RELA/DDX58/POLR1D/IL18/IFNA17/ZBP1/POLR3B/POLR3GL/IRF7/POLR3G/IL6/POLR3A	58
KEGG	hsa04520	Adherens junction	65/6806	71/8135	0.0423	0.06633	0.02425	PTPN6/FARP2/PTPN1/IQGAP1/RAC1/ACTG1/FYN/CSNK2B/RHOA/MAPK1/VCL/ACTN1/WASL/CSNK2A2/WAS/CTNNA1/EP300/RAC2/MAP3K7/SMAD4/CSNK2A1/MAPK3/SMAD3/ACP1/ACTB/BAIAP2/WASF3/CDC42/SSX2IP/SNAI2/ACTN4/PTPRB/IGF1R/PARD3/TGFBR2/PTPRM/TCF7/SNAI1/ERBB2/PTPRJ/YES1/WASF2/CTNNB1/INSR/PTPRF/CTNNA3/SRC/TGFBR1/CTNNA2/LEF1/TCF7L2/FGFR1/CREBBP/SORBS1/CDH1/LMO7/TCF7L1/WASF1/RAC3/TJP1/FER/NLK/EGFR/CTNND1/MET	65
KEGG	hsa03050	Proteasome	43/6806	46/8135	0.04397	0.06863	0.02509	PSMB4/PSMD6/PSMA6/PSMB1/POMP/PSMA3/PSMD13/PSMA2/PSMC4/PSMC1/PSMA7/PSMA5/PSMD7/PSMD12/PSMB10/PSMC6/PSMB3/PSMD9/PSMD4/PSMB9/PSMA1/PSMD1/PSME1/PSMB5/PSMC2/PSMC5/PSME2/PSMD11/PSMD8/PSMD2/PSMA4/PSMB6/PSMB8/PSME3/PSMC3/PSMB7/ADRM1/PSMD3/IFNG/PSMB2/PSMD14/PSMA8/PSME4	43
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	35/6806	37/8135	0.0454	0.07053	0.02579	AGXT2/ASPA/ADSL/GLUD1/ASL/RIMKLB/NAT8L/GFPT2/CAD/ABAT/GLUD2/ASNS/GLS/NIT2/GOT1/GLUL/ALDH4A1/GOT1L1/GPT/DDO/ASRGL1/GOT2/GFPT1/IL4I1/GAD2/FOLH1/GPT2/ALDH5A1/AGXT/GAD1/GLS2/RIMKLA/ASS1/PPAT/CPS1	35
KEGG	hsa00120	Primary bile acid biosynthesis	17/6806	17/8135	0.04805	0.07429	0.02716	CYP7A1/CYP7B1/AKR1C4/AKR1D1/CYP46A1/AMACR/HSD17B4/CYP8B1/SLC27A5/ACOT8/SCP2/HSD3B7/CH25H/CYP27A1/ACOX2/CYP39A1/BAAT	17
KEGG	hsa02010	ABC transporters	42/6806	45/8135	0.04959	0.07598	0.02778	ABCA3/ABCB11/ABCD1/ABCA2/ABCB7/ABCA5/ABCC1/ABCD4/CFTR/ABCB6/ABCA12/TAP1/ABCA7/ABCC8/ABCB10/ABCC10/ABCB1/ABCB4/ABCA1/ABCC5/ABCC4/TAP2/ABCC2/ABCB8/ABCG5/ABCA4/ABCB5/ABCC3/ABCD2/ABCG8/ABCB9/ABCD3/ABCG1/ABCG2/ABCA9/ABCA8/ABCC12/ABCC11/ABCA6/ABCC6/ABCA13/ABCC9	42
KEGG	hsa03022	Basal transcription factors	42/6806	45/8135	0.04959	0.07598	0.02778	GTF2F2/GTF2F1/GTF2H1/ERCC3/GTF2A2/CDK7/TAF7/CCNH/GTF2B/TAF2/GTF2E2/TAF12/GTF2I/GTF2H5/TAF9B/TAF1/TAF4/GTF2H2/GTF2H2C/TAF9/TAF5L/TBPL1/TAF1L/TAF3/TAF13/TAF10/MNAT1/TAF8/TAF6/GTF2E1/GTF2A1L/TAF5/TAF15/TAF11/TBP/GTF2H3/ERCC2/TAF7L/GTF2IRD1/GTF2A1/GTF2H4/TAF6L	42
KEGG	hsa05320	Autoimmune thyroid disease	49/6806	53/8135	0.05152	0.07824	0.0286	IL2/IFNA2/IFNA1/IFNA13/HLA-E/CD40/HLA-DRA/HLA-C/HLA-B/HLA-A/FAS/IL4/IFNA8/HLA-DMA/CGA/GZMB/HLA-G/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA16/HLA-F/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL10/CD86/HLA-DRB3/HLA-DRB5/PRF1/FASLG/HLA-DOA/IFNA17/CTLA4/HLA-DPA1/CD40LG/CD28/HLA-DPB1/TSHB/CD80/HLA-DOB/HLA-DQA1/HLA-DQA2/TPO	49
KEGG	hsa00500	Starch and sucrose metabolism	34/6806	36/8135	0.05177	0.07824	0.0286	SI/GYS2/UGP2/HK3/PGM1/GPI/PYGM/G6PC/GAA/PYGL/GCK/GYS1/G6PC3/AMY1A/AMY1B/AMY1C/AMY2A/HK2/HKDC1/AGL/PGM2/GYG1/G6PC2/MGAM/PYGB/ENPP3/GBA3/HK1/GBE1/TREH/AMY2B/PGM2L1/GANC/ENPP1	34
KEGG	hsa03030	DNA replication	34/6806	36/8135	0.05177	0.07824	0.0286	POLA2/RNASEH2C/MCM7/RNASEH2A/POLD3/FEN1/MCM5/RPA3/POLE4/RFC3/RFC1/POLE3/SSBP1/POLD4/RNASEH1/RFC2/PCNA/POLD1/POLE/MCM2/RPA2/LIG1/MCM3/RFC5/RFC4/POLD2/RPA1/RNASEH2B/MCM6/POLE2/PRIM1/PRIM2/POLA1/MCM4	34
KEGG	hsa04730	Long-term depression	55/6806	60/8135	0.05771	0.08682	0.03174	IGF1/GNAQ/PPP2CA/CRHR1/PRKG2/GNA13/MAP2K2/PLCB2/PLA2G4D/GNAI1/PRKCB/MAPK1/ARAF/GRIA2/CRH/HRAS/RAF1/ITPR3/GNA11/PPP2R1A/PLA2G4C/MAPK3/JMJD7-PLA2G4B/PLA2G4B/IGF1R/PLA2G4F/GNAI2/GUCY1A2/LYN/GNAI3/GNAS/PLCB4/NRAS/ITPR1/GNAZ/GNAO1/GRID2/ITPR2/KRAS/PLCB3/BRAF/RYR1/PPP2CB/PLCB1/PLA2G4A/PRKCG/GNA12/PRKCA/GRIA1/PRKG1/GRIA3/CACNA1A/MAP2K1/GRM1/NOS1	55
KEGG	hsa03015	mRNA surveillance pathway	87/6806	97/8135	0.06399	0.09584	0.03504	PABPC5/PABPC1L2B/PABPC4L/RNGTT/PPP2CA/PPP2R5D/UPF1/PPP2R5C/CASC3/PPP2R2D/SSU72/NXF1/CSTF2/SMG5/SAP18/PPP2R2C/ACIN1/RNPS1/PABPC1/NCBP1/UPF2/PABPN1/CPSF7/FIP1L1/ETF1/PPP2R2A/DDX19A/DDX19B/PPP1CA/CSTF1/EIF4A3/PPP2R1A/CPSF6/PELO/PPP1CB/MSI2/NXT2/CPSF3/CLP1/PCF11/PABPC1L/PPP2R5B/SMG6/PNN/MAGOH/PPP1CC/SMG7/SYMPK/CPSF1/CPSF2/CSTF2T/RNMT/MAGOHB/SRRM1/UPF3A/NXF2/NXF2B/WDR33/PABPC3/PPP2R3C/SMG1/PPP2R5A/MSI1/PPP2R5E/NXT1/PAPOLA/PPP2R3A/PPP2R2B/RBM8A/PAPOLB/PPP2R3B/TARDBP/FUS/PPP2CB/WDR82/GLE1/NCBP2/NUDT21/GSPT2/CSTF3/HBS1L/PAPOLG/PABPC4/CPSF4/UPF3B/DAZAP1/GSPT1	87
KEGG	hsa05016	Huntington disease	266/6806	306/8135	0.06441	0.09604	0.03511	COX6A2/COX4I2/SLC25A31/COX8C/NDUFS7/NDUFS1/UQCRQ/UQCRB/PIK3C3/NDUFC1/NDUFA1/GPX5/TUBA1C/NDUFS2/PSMB4/NDUFV2/PSMD6/CREB3/GNAQ/CASP9/NDUFB10/COX5B/SDHB/NDUFB3/NDUFB11/PSMA6/ACTR10/PSMB1/POLR2E/PSMA3/HDAC2/PSMD13/UQCRH/TUBA1B/PLCB2/HTT/POLR2G/SLC25A4/NDUFB4/AP2M1/POLR2B/BAX/CASP3/VDAC2/NDUFA2/PSMA2/TUBA1A/NDUFA7/NDUFA10/COX7B/PSMC4/POLR2J/SOD1/UQCR10/PSMC1/PSMA7/COX8A/WIPI2/BECN1/HDAC1/PIK3R4/PSMA5/DCTN6/SLC25A5/PSMD7/DCTN3/PSMD12/KLC1/TUBA4A/PSMC6/PSMB3/NDUFB8/GRIA2/NDUFS8/NDUFA13/CLTA/TFAM/COX6B1/PSMD9/POLR2A/PSMD4/UQCRFS1/UQCRC2/NDUFB2/DNAH1/POLR2I/NDUFS4/NRBF2/DLG4/NDUFB6/NDUFA12/ACTR1A/COX6B2/PSMA1/CLTC/EP300/SDHA/COX4I1/NDUFA4/CLTB/DNAH9/CYC1/POLR2K/PSMD1/DCTN1/TAF4/MTOR/NDUFA3/NDUFV1/DNAL4/NDUFA8/PSMB5/RB1CC1/PSMC2/TUBA3D/TUBA3E/TUBAL3/POLR2F/TUBB1/NDUFS3/NDUFC2/PSMC5/AP2S1/TBPL1/SIN3A/POLR2C/ACTR1B/NDUFA11/PSMD11/COX6C/UQCR11/NDUFA9/KLC4/NDUFA6/MAPK9/AP2B1/SDHC/APAF1/COX7A2/PSMD8/CLTCL1/DCTN5/PSMD2/HAP1/TRAF2/STX1A/PSMA4/PSMB6/PPIF/NDUFAB1/RCOR1/TUBB/AP2A2/CASP8/DNAH17/PSMC3/PSMB7/TUBA3C/ADRM1/MAP3K5/DNAH7/POLR2H/DNAH2/MAP3K10/KIF5B/NDUFB7/KIF5C/NDUFB9/SOD2/DCTN4/NDUFV3/TUBA8/PLCB4/POLR2L/NDUFS5/GPX7/DCTN2/ULK2/ITPR1/COX5A/PSMD3/DNAL1/ATG2A/BBC3/NDUFS6/COX7B2/VDAC3/COX6A1/DNAI1/NDUFA5/ATG2B/COX7C/CREB3L4/SLC25A6/SDHD/AMBRA1/TBP/UCP1/BDNF/TUBB6/GPX2/NDUFB1/CREB3L2/PLCB3/CYCS/AP2A1/WIPI1/NDUFB5/DNAH10/GRIN2B/PSMB2/CREB5/NRF1/PSMD14/DNAI2/TUBB3/MAP2K7/TP53/MAPK8/PSMA8/DNAH11/ULK1/CREB3L1/PLCB1/UQCRC1/KLC3/CREB1/IFT57/HIP1/KCNJ10/POLR2J3/DNAH5/GRIN1/DNAH8/SLC1A2/MAPK10/POLR2J2/GPX1/GRIA1/POLR2D/NDUFA4L2/GRIA4/KIF5A/VDAC1/CACNA1B/TGM2/GRIA3/DNALI1/COX7A2L/CREBBP/SLC1A3/REST/GPX8/KLC2/SP1/DNAH14/DNAH3/DNAH6/TUBB2B/CREB3L3/PPARG/GPX3/DNAH12/ERN1/GRM5/PPARGC1A	266
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	15/6806	15/8135	0.06869	0.102	0.03728	B4GALNT1/ST8SIA5/SLC33A1/B3GALT4/GLB1/HEXB/ST3GAL1/HEXA/ST3GAL2/ST6GALNAC5/ST6GALNAC4/ST3GAL5/ST6GALNAC6/ST8SIA1/ST6GALNAC3	15
KEGG	hsa05014	Amyotrophic lateral sclerosis	315/6806	364/8135	0.07164	0.1059	0.03871	UBQLN3/COX6A2/COX4I2/COX8C/NDUFS7/NDUFS1/UQCRQ/UQCRB/PIK3C3/NDUFC1/NDUFA1/GPX5/TUBA1C/NDUFS2/PSMB4/NDUFV2/PSMD6/ATXN2L/HSPA5/BAD/CASP9/ATF4/NDUFB10/SEC13/COX5B/SDHB/NDUFB3/RAC1/NDUFB11/PSMA6/ACTR10/PSMB1/ACTG1/PPP3R2/PSMA3/NXF1/PSMD13/UQCRH/TNFRSF1B/TUBA1B/RAE1/VCP/MAPK14/NDUFB4/BAX/CASP3/NDUFA2/ANXA11/CAT/PSMA2/TUBA1A/NDUFA7/NDUFA10/COX7B/PSMC4/SOD1/UQCR10/DAXX/PSMC1/PSMA7/COX8A/WIPI2/BECN1/TOMM40L/FIG4/PIK3R4/NCBP1/PFN1/ALS2/SMCR8/PSMA5/DCTN6/PSMD7/RAB1A/DCTN3/PSMD12/TANK/KLC1/TUBA4A/PSMC6/PSMB3/NUP153/NDUFB8/GRIA2/XBP1/NDUFS8/NDUFA13/NUP62/COX6B1/PSMD9/SETX/PSMD4/TBK1/UQCRFS1/UQCRC2/POM121/POM121C/NUP214/NUP205/NDUFB2/DNAH1/MAP1LC3A/UBQLN1/NDUFS4/MAP1LC3B/NRBF2/TNFRSF1A/NDUFB6/EIF2S1/NDUFA12/ACTR1A/ITPR3/COX6B2/PSMA1/PINK1/SDHA/NUP98/NEFL/COX4I1/NDUFA4/NUP93/DNAH9/CYC1/PSMD1/BID/DCTN1/SQSTM1/MTOR/NDUFA3/NDUFV1/DNAL4/NUP50/MAP1LC3C/NUP85/HNRNPA2B1/NDUFA8/MAPK12/PSMB5/RB1CC1/PSMC2/TUBA3D/TUBA3E/CHMP2B/TUBAL3/TUBB1/NUP133/NDUFS3/NDUFC2/PSMC5/NXT2/C9orf72/ACTB/ACTR1B/NDUFA11/PSMD11/COX6C/UQCR11/NDUFA9/NUP37/CCS/KLC4/DDIT3/NDUFA6/TNF/MAPK13/MATR3/NUP88/SDHC/APAF1/COX7A2/PSMD8/PFN4/DCTN5/PSMD2/TOMM40/ANXA7/UBQLN2/HAP1/TRAF2/PSMA4/PSMB6/NDUFAB1/HNRNPA3/TUBB/HDAC6/DNAH17/PSMC3/TPR/PSMB7/TUBA3C/ADRM1/MAP3K5/MAP2K6/DNAH7/DNAH2/CHCHD10/KIF5B/ANG/NDUFB7/KIF5C/PPP3CA/NDUFB9/ATXN2/DCTN4/NDUFV3/TUBA8/RAB8A/RAB39B/NXF2/NXF2B/NEFM/NDUFS5/GPX7/DCTN2/ULK2/RANBP2/ATF6/MAP1LC3B2/NEFH/EIF2AK3/COX5A/PSMD3/NUP188/CASP12/SPG11/DNAL1/ATG2A/NDUFS6/COX7B2/NUP155/COX6A1/DNAI1/GRIN2D/RAB5A/NDUFA5/ATG2B/SIGMAR1/PPP3CB/HNRNPA1/HNRNPA1L2/MAPK11/COX7C/NUP160/NRG1/WDR41/SDHD/AMBRA1/NXT1/DERL1/TUBB6/GPX2/NUP54/PPP3CC/NUP35/NDUFB1/CYCS/NUP210/WIPI1/GRIN2C/NDUFB5/DNAH10/GRIN2B/TARDBP/CASP1/PSMB2/FUS/PFN2/PSMD14/DNAI2/TUBB3/GLE1/TP53/PSMA8/DNAH11/ULK1/BCL2L1/UQCRC1/KLC3/UBQLN4/ERBB4/GRIN2A/NUP43/PPP3R1/DNAH5/GRIN1/DNAH8/SLC1A2/NUP107/GPX1/GRIA1/OPTN/BCL2/NDUFA4L2/SEH1L/KIF5A/MAP2K3/VDAC1/VAPB/DNALI1/COX7A2L/GPX8/KLC2/NOS2/NOS1/POM121L2/NRG4/DNAH14/NRG2/DNAH3/DNAH6/PRPH/TUBB2B/GPX3/DNAH12/ERN1	315
KEGG	hsa01212	Fatty acid metabolism	52/6806	57/8135	0.07817	0.115	0.04205	PPT2/ELOVL2/ACAA1/HADHA/MECR/HADHB/CPT1C/HADH/ACADVL/CPT1A/ELOVL1/ECHS1/ACAA2/ACADS/ACSBG2/ELOVL5/TECR/FADS2/CPT2/ACSL3/ACSF3/ACADSB/HSD17B4/ACADL/ACSL4/OXSM/PPT1/HSD17B12/ACOX1/ELOVL4/MCAT/ACSL1/SCP2/CBR4/ACAT2/ACAT1/FADS1/ACSBG1/ELOVL3/ACSL5/ELOVL7/FASN/ACSL6/HSD17B8/ACACA/SCD5/CPT1B/ELOVL6/ACOX3/ACADM/SCD/EHHADH	52
KEGG	hsa05202	Transcriptional misregulation in cancer	169/6806	193/8135	0.07958	0.1166	0.04262	MMP3/IGF1/PLAT/CD40/SS18/ZBTB17/MEIS1/SIX1/HDAC2/RUNX1/BAX/MDM2/GADD45B/SIX4/HOXA10/HDAC1/BAK1/CD14/BCL6/ASPSCR1/WNT16/SPI1/AFF1/MYCN/BCL2A1/RXRB/JMJD1C/KLF3/CDK14/SUPT3H/FEV/CSF1R/SPINT1/CEBPB/ITGAM/LDB1/FUT8/NFKB1/TLX1/MEN1/NFKBIZ/EYA1/MLLT1/ETV4/RARA/PER2/SIN3A/FLI1/CCNT2/DDIT3/RXRA/LMO2/ID2/ETV6/HHEX/TFE3/MAX/SMAD1/IGF1R/ATM/TGFBR2/FOXO1/EWSR1/CEBPE/CDKN1B/CSF2/CDKN2C/NUPR1/NTRK1/ARNT2/PRCC/BAIAP3/MYC/MITF/DDB2/POLK/BMP2K/GZMB/CCND2/IL1R2/ITGB7/PAX3/PLAU/BIRC2/TAF15/PAX8/IL3/NCOR1/DDX5/KDM6A/MMP9/CD86/PBX3/CEBPA/IL2RB/PTK2/TMPRSS2/FUS/PTCRA/FCGR1A/TRAF1/BMI1/HPGD/TP53/GADD45A/CCNA2/NR4A3/DEFA5/LYL1/HOXA9/BCL2L1/FLT1/CDKN1A/RELA/PAX5/ETV5/ATF1/PML/MEF2C/ZEB1/RUNX2/ELK4/BCL11B/DOT1L/SS18L1/MLLT3/SLC45A3/FLT3/RUNX1T1/TCF3/DEFA1/DEFA1B/DEFA3/TLX3/MPO/GADD45G/DUSP6/PDGFA/ZBTB16/ERG/RXRG/DEFA6/HOXA11/HMGA2/IL6/GRIA3/DEFA4/CCNT1/SSX1/BIRC3/WT1/REL/SP1/PBX1/CDK9/NGFR/MAF/TSPAN7/CCNA1/SSX2/SSX2B/PROM1/MET/PPARG/PAX7/MLF1/ETV7/ETV1/IGFBP3	169
KEGG	hsa05131	Shigellosis	215/6806	247/8135	0.08211	0.1193	0.04361	IFNB1/PLCD1/PIK3C3/ARPC1A/TLN1/DIAPH1/NFKBIB/ARHGEF2/CYTH1/ITGA5/UBC/RAC1/RPTOR/ACTG1/FNBP1/ARF1/CRKL/CAPNS1/NLRC4/RHOA/PLCB2/RRAGA/MAPK14/CALCOCO2/IL1B/BAX/MDM2/ARPC4/ATG5/U2AF1/ACTR2/WIPI2/BECN1/ARPC1B/MAPK1/PIK3CB/ILK/ELMO1/PIK3R4/CD14/PFN1/HK3/VCL/ELMO2/AKT1S1/ACTN1/IKBKG/BCAR1/MYD88/MYLPF/WASL/PIK3CD/ARPC2/AKT3/CYTH4/RRAGD/TBK1/GSK3A/RIPK2/MAP1LC3A/MAP1LC3B/TNFRSF1A/RPS6KB2/ITPR3/NFKBIA/RIPK1/ARPC5/PYCARD/ROCK1/MAP3K7/IRF3/ARPC3/SQSTM1/MTOR/PLCG2/UBE2D2/PRKCD/MAPK3/MAP1LC3C/PXN/UBA52/PIK3CA/CASP4/NFKB1/MAPK12/RBCK1/UBE2V1/ACTR3B/BTRC/TRAF6/ARPC5L/ACTB/C3/ATG12/U2AF1L4/PIK3R2/ROCK2/CDC42/TNF/MAPK13/MAPK9/IKBKB/TIFA/TLR5/ACTN4/NOD1/PFN4/CYTH3/TRADD/TRAF2/ATM/BNIP3/TAB2/AKT2/CBX3/FOXO1/PIK3R1/UBE2NL/TNIP1/MYL12A/MYL12B/CSF2/HCLS1/UBE2D1/PLCD4/FBXW11/NLRP3/NAIP/MALT1/GSK3B/TAB1/JUN/CAST/PLCB4/CUL1/AKT1/PRKCQ/HK2/CCL5/ITPR1/MAP1LC3B2/UBE2D3/HKDC1/FOXO6/PLCZ1/ACTR3/MYL10/RRAGC/CRK/GLMN/PLCD3/RNF31/RRAGB/MAPK11/ITPR2/ATG16L1/ARF6/CTTN/CHUK/TLN2/ITGB1/CD44/MYL9/TAB3/IL1R1/PPID/UBE2N/PLCB3/RPS6KB1/RBX1/CYCS/CAPN2/WIPI1/PTK2/FOXO4/CASP1/PFN2/SKP1/WASF2/TP53/MAPK8/HK1/PLCB1/BCL2L1/UBE2D4/RELA/SHARPIN/IL18/PLCG1/UBB/FOXO3/TLR4/SRC/MYL7/RPS27A/MAPK10/MYL5/PIK3R3/DOCK1/MYL2/TRAF5/BCL2/RPS6KA5/PRKCE/CYTH2/VDAC1/BCL10/UBE2V2/FNBP1L/TECPR1/PLCE1/WASF1/ACTR3C/EGFR/CAPN1	215
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	14/6806	14/8135	0.08214	0.1193	0.04361	B4GALT1/B3GNT7/B4GALT2/ST3GAL1/B4GALT3/FUT8/CHST2/ST3GAL2/B4GALT4/B3GNT2/ST3GAL3/CHST4/CHST1/CHST6	14
KEGG	hsa05020	Prion disease	237/6806	273/8135	0.08612	0.1244	0.04549	COX6A2/NCAM2/COX4I2/SLC25A31/COX8C/RYR3/NDUFS7/NDUFS1/UQCRQ/UQCRB/NDUFC1/NDUFA1/TUBA1C/NDUFS2/PSMB4/NDUFV2/PSMD6/CREB3/HSPA5/BAD/CASP9/ATF4/NDUFB10/C9/COX5B/SDHB/NDUFB3/RAC1/NDUFB11/PSMA6/PSMB1/PPP3R2/PSMA3/PSMD13/UQCRH/FYN/CSNK2B/TUBA1B/SLC25A4/MAPK14/CACNA1C/NCF4/NDUFB4/IL1B/BAX/CASP3/VDAC2/NDUFA2/PSMA2/TUBA1A/NDUFA7/NDUFA10/COX7B/PSMC4/SOD1/UQCR10/PSMC1/PSMA7/COX8A/MAPK1/PIK3CB/C6/NOTCH1/PSMA5/SLC25A5/CACNA1S/PSMD7/NCF1/PSMD12/KLC1/TUBA4A/PSMC6/PSMB3/PRNP/NDUFB8/NDUFS8/NDUFA13/ATF6B/COX6B1/PIK3CD/PRKACA/PSMD9/CSNK2A2/PSMD4/UQCRFS1/UQCRC2/NDUFB2/NCF2/NDUFS4/NDUFB6/EIF2S1/NDUFA12/ITPR3/COX6B2/PSMA1/SDHA/RAC2/COX4I1/NDUFA4/CYC1/PSMD1/HSPA1L/NDUFA3/CSNK2A1/NDUFV1/PRKCD/MAPK3/PIK3CA/NDUFA8/MAPK12/HSPA6/PSMB5/PSMC2/TUBA3D/TUBA3E/TUBAL3/TUBB1/NDUFS3/NDUFC2/PSMC5/NDUFA11/PSMD11/COX6C/UQCR11/PIK3R2/NDUFA9/KLC4/DDIT3/NDUFA6/TNF/MAPK13/MAPK9/SDHC/APAF1/HSPA8/COX7A2/PSMD8/PSMD2/HSPA1B/PSMA4/PSMB6/PPIF/CYBA/NDUFAB1/TUBB/PIK3R1/PSMC3/CACNA1F/PSMB7/TUBA3C/ADRM1/CYBB/KIF5B/NDUFB7/KIF5C/C1QB/PPP3CA/NDUFB9/GSK3B/NDUFV3/STIP1/TUBA8/NDUFS5/C1QA/CCL5/ITPR1/EIF2AK3/COX5A/PSMD3/CASP12/NDUFS6/COX7B2/HSPA1A/VDAC3/COX6A1/GRIN2D/NDUFA5/PPP3CB/MAPK11/ITPR2/COX7C/CREB3L4/SLC25A6/SDHD/TUBB6/PPP3CC/NDUFB1/CREB3L2/CYCS/PRKACB/PRKACG/GRIN2C/NDUFB5/EGR1/GRIN2B/PSMB2/CREB5/RYR1/CACNA1D/PSMD14/LAMC1/TUBB3/MAPK8/PSMA8/CREB3L1/UQCRC1/KLC3/C5/GRIN3B/ATF2/CREB1/GRIN2A/PPP3R1/GRIN3A/C8A/GRIN1/MAPK10/PIK3R3/NDUFA4L2/CAV2/KIF5A/RYR2/VDAC1/CACNA1B/IL6/NCAM1/COX7A2L/HSPA2/KLC2/C8B/C1QC/TUBB2B/C8G/CREB3L3/CAV1/C7/IL1A	237
KEGG	hsa04215	Apoptosis - multiple species	30/6806	32/8135	0.08642	0.1244	0.04549	CASP9/BCL2L11/BAX/CASP3/BECN1/HTRA2/BAK1/FADD/TNFRSF1A/BID/XIAP/MAPK9/APAF1/CASP8/BIRC6/BBC3/BIRC7/BIRC2/CYCS/MAPK8/BCL2L1/CASP7/MAPK10/DIABLO/BCL2/PMAIP1/BOK/BIRC3/NGFR/BIRC5	30
KEGG	hsa00280	Valine, leucine and isoleucine degradation	44/6806	48/8135	0.08831	0.1266	0.04628	AGXT2/ACAA1/HADHA/AOX1/HADHB/ACAD8/HMGCL/BCKDHA/DLD/HADH/ALDH9A1/ECHS1/ACAA2/AACS/ACADS/HSD17B10/ALDH2/IVD/HIBADH/ACSF3/ACADSB/ABAT/PCCA/HMGCS1/MCCC1/AUH/MCEE/OXCT2/ALDH1B1/ALDH3A2/HMGCS2/OXCT1/BCKDHB/DBT/ALDH7A1/ACAT2/ACAT1/BCAT1/HIBCH/PCCB/IL4I1/BCAT2/ACADM/EHHADH	44
KEGG	hsa03060	Protein export	22/6806	23/8135	0.09046	0.128	0.0468	HSPA5/SRP19/SRP9/SRP72/OXA1L/SEC61B/SRP14/SRP54/SEC61A1/IMMP2L/SPCS1/SEC61A2/SEC11C/SEC11A/SEC61G/SRP68/SEC62/SRPRB/SEC63/SPCS2/IMMP1L/SPCS3	22
KEGG	hsa03430	Mismatch repair	22/6806	23/8135	0.09046	0.128	0.0468	MSH3/PMS2/MSH6/POLD3/RPA3/RFC3/RFC1/SSBP1/MLH3/MLH1/POLD4/RFC2/PCNA/POLD1/MSH2/RPA2/LIG1/RFC5/RFC4/POLD2/RPA1/EXO1	22
KEGG	hsa04614	Renin-angiotensin system	22/6806	23/8135	0.09046	0.128	0.0468	MAS1/PRCP/CTSA/CMA1/REN/ANPEP/ATP6AP2/PREP/KLK1/MME/AGTR1/CPA3/KLK2/LNPEP/AGTR2/ENPEP/NLN/ACE2/ACE/THOP1/CTSG/AGT	22
KEGG	hsa04710	Circadian rhythm	29/6806	31/8135	0.09791	0.138	0.05044	CLOCK/BHLHE40/CSNK1E/CRY2/PRKAB1/BHLHE41/ARNTL/CSNK1D/BTRC/PER2/PRKAG2/FBXW11/RORC/CUL1/NPAS2/PRKAA1/PER1/PRKAG1/NR1D1/RBX1/SKP1/CRY1/CREB1/RORA/RORB/FBXL3/PRKAG3/PRKAB2/PRKAA2	29
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	69/6806	77/8135	0.09857	0.1383	0.05057	CACNB3/ITGA11/CACNB1/ITGA5/ACTG1/ITGA2/CACNA1C/ITGB4/CACNG1/CDH2/CACNA1S/CACNA2D1/LAMA2/CTNNA1/ATP2A2/CACNG8/ITGA4/ATP2A3/CACNA2D4/ACTB/ITGA2B/ITGA9/CACNA2D2/CACNA1F/EMD/DAG1/ACTN3/TCF7/SLC8A1/SGCB/LAMA1/ITGA7/SGCG/DSC2/ITGA10/ITGB7/CACNA2D3/ITGB1/SLC8A3/CACNB2/LMNA/CACNG3/CACNA1D/CTNNB1/DES/ITGAV/ITGB3/ITGA8/CTNNA3/CACNG4/ITGB8/CTNNA2/LEF1/TCF7L2/CACNG5/DMD/RYR2/ITGB5/CACNG2/SGCA/DSG2/GJA1/TCF7L1/ITGA3/CACNG6/ITGA6/ACTN2/SLC8A2/SGCD	69
KEGG	hsa00220	Arginine biosynthesis	21/6806	22/8135	0.1043	0.1458	0.0533	OTC/ACY1/GLUD1/ASL/NAGS/GLUD2/GLS/NOS3/GOT1/GLUL/GOT1L1/GPT/ARG2/GOT2/GPT2/ARG1/GLS2/NOS2/NOS1/ASS1/CPS1	21
KEGG	hsa00030	Pentose phosphate pathway	28/6806	30/8135	0.1107	0.1541	0.05635	ALDOB/TKTL2/ALDOA/TALDO1/TKT/FBP1/DERA/PRPS1L1/GLYCTK/PGM1/GPI/G6PD/PRPS2/PGD/RBKS/PGLS/PFKP/PFKM/ALDOC/PGM2/RPE/PFKL/RGN/PRPS1/H6PD/TKTL1/FBP2/RPIA	28
KEGG	hsa04978	Mineral absorption	54/6806	60/8135	0.1199	0.1661	0.06074	TRPV6/ATP7A/FTH1/SLC11A2/HMOX2/SLC31A1/VDR/ATP2B3/SLC34A2/SLC39A4/SLC26A6/FTL/ATP1B3/ATP2B2/ATOX1/ATP2B1/SLC26A3/ATP2B4/S100G/MT1X/SLC34A1/SLC8A1/MT1H/TF/SLC30A1/STEAP2/HMOX1/SLC8A3/ATP1A1/SLC9A3/SLC40A1/CYBRD1/TRPM6/FXYD2/MT1F/SLC46A1/HEPH/SLC6A19/MT2A/CLCN2/TRPM7/ATP1B1/SLC26A9/MT1G/ATP1A4/SLC5A1/MT1E/SLC34A3/ATP1A2/STEAP1/ATP1A3/ATP1B4/ATP7B/SLC8A2	54
KEGG	hsa05143	African trypanosomiasis	34/6806	37/8135	0.1239	0.171	0.06252	IL12A/GNAQ/NPPA/PLCB2/IL1B/PRKCB/MYD88/HBB/APOA1/TLR9/FAS/TNF/PLCB4/F2RL1/SELE/ICAM1/APOL1/IL12B/IL10/IFNG/PLCB3/KNG1/HPR/FASLG/PLCB1/PRKCG/IL18/PRKCA/VCAM1/IDO1/THOP1/IL6/IDO2/LAMA4	34
KEGG	hsa04260	Cardiac muscle contraction	77/6806	87/8135	0.1378	0.1894	0.06922	CASQ2/COX6A2/COX4I2/COX8C/CACNB3/UQCRQ/UQCRB/CACNB1/COX5B/TRDN/UQCRH/CACNA1C/CACNG1/COX7B/UQCR10/COX8A/CACNA1S/CACNA2D1/TNNC1/COX6B1/UQCRFS1/UQCRC2/ATP2A2/COX6B2/SLC9A6/COX4I1/CACNG8/CYC1/SLC9A1/ATP2A3/ATP1B3/CACNA2D4/COX6C/UQCR11/COX7A2/MYH6/TNNT2/TPM4/SLC9A7/CACNA2D2/CACNA1F/SLC8A1/TPM3/COX5A/COX7B2/COX6A1/COX7C/CACNA2D3/SLC8A3/CACNB2/ATP1A1/TPM2/MYH7/FXYD2/CACNG3/CACNA1D/MYL4/HRC/ACTC1/UQCRC1/ASPH/CACNG4/ATP1B1/MYL2/CACNG5/TPM1/RYR2/COX7A2L/ATP1A4/CACNG2/ATP1A2/ATP1A3/ATP1B4/MYL3/CACNG6/TNNI3/SLC8A2	77
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	11/6806	11/8135	0.1404	0.1922	0.07025	VKORC1/COQ7/NQO1/COQ5/VKORC1L1/COQ2/COQ6/GGCX/COQ3/HPD/TAT	11
KEGG	hsa00230	Purine metabolism	112/6806	128/8135	0.1428	0.1947	0.07117	PDE8A/PDE6A/PDE1A/PDE6G/NT5C1B/ADSL/ADCY8/ITPA/PDE4D/PDE6D/NME6/GMPS/PDE4B/PRPS1L1/DGUOK/ENTPD4/NME1-NME2/NME2/GUCY2D/ENTPD2/PGM1/NME3/AMPD2/PFAS/AK2/NUDT16/NUDT5/NT5C2/APRT/ENTPD6/RRM2B/PRPS2/ENTPD5/NT5C/NUDT2/NT5M/HDDC2/NPR1/GMPR2/AK1/CANT1/AMPD3/PAPSS2/ATIC/GUK1/HPRT1/PAICS/PAPSS1/ENPP4/NPR2/ADCY6/PDE1B/GUCY1A2/PDE3A/ENTPD1/PDE11A/XDH/IMPDH2/ENTPD3/NME4/IMPDH1/PNP/PDE7B/PGM2/HDDC3/ADCY9/NUDT9/NT5DC4/ADCY4/AK3/PDE6C/AMPD1/ENPP3/GDA/GMPR/PDE10A/ADK/AK5/NME1/PDE3B/PDE2A/ADCY7/PRPS1/RRM1/GUCY2F/PDE6B/AK7/FHIT/ADA/NT5E/ALLC/PDE7A/PDE5A/PDE4A/DCK/PDE4C/ADCY5/GUCY2C/ADCY10/PDE6H/ADCY3/PDE1C/ADCY1/PDE9A/RRM2/NME7/ADCY2/PPAT/PDE8B/GART/NT5C1A/ENPP1	112
KEGG	hsa05168	Herpes simplex virus 1 infection	423/6806	495/8135	0.1466	0.199	0.07275	IFNA2/IFNB1/ZNF99/ZNF560/ZNF114/IFNA1/IFNA13/ZNF221/IL12A/ZNF480/ZNF225/HLA-E/ZNF34/ZNF304/ZNF567/ZNF74/ZNF782/ZNF383/ZNF250/TNFRSF14/BAD/CASP9/ZNF93/ZNF565/ZNF584/ITGA5/ZNF41/ZNF268/ZNF562/ZNF155/NXF1/ZIM3/IFNGR2/ZNF214/CARD9/CFP/TICAM1/IL1B/ZNF669/ZNF124/BAX/ZNF700/CASP3/EIF2B4/EIF2B3/ZNF57/ZNF180/EIF2B2/TSC2/TSC1/TAPBP/ZNF230/TYK2/DAXX/ZNF273/PIK3CB/BAK1/ZNF416/EIF2B1/IRAK1/ZNF43/SYK/ZNF701/ZNF224/ZNF777/ZNF79/RHEB/IKBKG/MYD88/PIK3CD/ZNF211/AKT3/ZNF85/TBK1/ZNF317/PILRA/ZNF707/EIF2B5/ZNF222/PPP1CA/ZNF398/ZNF44/FADD/TRAF3/TNFRSF1A/HLA-DRA/MAVS/EIF2S1/ZNF791/ZNF621/ZNF91/ZNF133/IFNAR1/NFKBIA/ZNF555/EIF4EBP1/ZNF786/ZNF823/ZNF680/HLA-C/ZNF226/ZNF620/ZNF101/TAP1/IRAK4/MAP3K7/ZNF184/BID/IRF3/POU2F2/ZNF557/ZNF585A/MTOR/ZNF689/ZNF564/ZNF282/ZNF768/PIK3CA/NFKB1/HLA-B/ZNF33A/ZNF227/ZNF559/ZNF461/TRAF6/PPP1CB/ZNF25/TLR9/C3/JAK1/HLA-A/FAS/PIK3R2/ZNF613/ZNF805/ZNF780B/ZNF354C/TNF/ZNF544/IKBKB/ZNF141/APAF1/ZNF713/SRPK1/ZNF558/ZNF616/ZNF599/ZNF439/ZNF551/TRADD/ZNF256/TRAF2/ZNF763/IFNA8/ZNF334/PPP1CC/CD74/TAB2/AKT2/PIK3R1/ZNF746/ZNF20/ZNF354A/CASP8/ZNF420/ZNF45/B2M/ZNF205/ZNF563/ZNF671/ZNF251/ZNF12/ZNF440/ZNF561/ZNF200/ZNF649/ZNF419/ZNF267/ZNF793/ZNF600/TAB1/JAK2/ZNF350/NXF2/NXF2B/ZNF7/ZNF23/AKT1/ZNF430/ZNF490/HLA-DMA/HCFC1/ZIK1/PILRB/CCL5/ZNF195/ZNF19/TNFSF14/ZNF780A/POU2F1/EIF2AK3/ZNF175/EIF2AK1/ZNF552/ZNF766/ZNF627/ZNF331/ZNF320/ZNF169/HLA-G/ZNF432/ZNF846/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/ZNF471/ZNF573/IFNA16/HLA-F/ZNF577/PDIA3/ZNF107/ZNF212/ZNF528/IRF9/IL12B/HLA-DRB1/HLA-DRB4/HLA-DQB1/ZNF316/ZNF436/BIRC2/CHUK/ZNF675/HLA-DMB/ZNF674/ZNF443/ZNF17/SP100/ZNF492/ZNF286A/TAP2/ZNF540/IKBKE/CALR/ZNF10/IFNG/HLA-DRB3/HLA-DRB5/ZNF404/ZNF182/HCFC2/TLR2/ZNF84/ZNF254/RBAK/ZNF177/ZNF624/ZNF764/ZNF566/CYCS/ZNF136/ZNF611/ZNF597/ZNF658/IFNGR1/LTA/ZNF595/ZNF736/FASLG/ZNF8/ZNF641/ZNF37A/ZNF708/ZNF337/ZNF606/ZNF324/RNASEL/HLA-DOA/ZNF343/TP53/ZFP90/ZNF506/ZNF619/ZNF333/ZNF605/ZNF688/ZNF615/SOCS3/ZNF14/ZNF879/ZNF568/BCL2L1/RELA/ZNF814/DDX58/ZNF614/ITGB3/ZNF324B/ZNF30/PML/C5/ZNF83/ZNF468/ZNF233/ZNF26/IFNA17/ZNF473/HLA-DPA1/ZNF90/ZNF836/ZNF160/ZNF585B/ZNF302/ZFP28/ZNF569/SRC/ZNF630/ZFP1/ZNF808/STAT2/ZNF813/PIK3R3/ZNF670/HLA-DPB1/ZFP37/ZNF311/IFIH1/ZNF33B/ZNF792/ZNF248/ZNF709/ZNF550/TRAF5/EIF2AK4/ZNF486/IRF7/BCL2/ZNF556/ZNF3/ZNF665/ZNF2/ZNF530/ZNF778/STAT1/ZNF470/ZNF484/ZNF479/ZNF460/ZNF283/CCL2/ZNF582/ZNF189/ZNF442/ZNF829/ZNF135/PTPN11/ZNF529/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/ZNF853/ZNF208/ZNF425/ZNF721/ZNF684/ZNF610/ZNF157/ZNF235/ZNF682/POU2F3/ZNF554/ZNF510/ZNF785/BIRC3/ZNF548/ZNF571/ZNF253/BST2/ZNF667/ZNF223/ZNF583/EIF2AK2/ZNF441/ZNF749/ZNF417/ZNF549/ZFP30/ZNF662/ZNF783/ZNF140/ZNF382/ZNF229/ZNF154/ZFP57/ZNF570/ZNF347/ZNF100/ZNF519/ZNF717/ZNF81/ZNF234/IFNAR2/ZNF596/ZNF300/ZNF677/ZNF765/OAS1/ZNF275/ZNF517/ZNF718/ZNF589/ZNF77/ZNF354B/ZNF426/ZNF514/ZNF607/ZFP82	423
KEGG	hsa05144	Malaria	45/6806	50/8135	0.1518	0.2053	0.07504	IL12A/CD40/ITGB2/TGFB1/THBS4/TGFB2/IL1B/MYD88/ITGAL/HBB/TLR9/LRP1/TNF/THBS3/SDC2/CD36/CD81/PECAM1/SELE/HGF/ICAM1/THBS1/SELP/IL10/IFNG/TLR2/COMP/SDC1/KLRK1/CR1L/KLRB1/CSF3/GYPC/IL18/THBS2/TLR4/CD40LG/VCAM1/CR1/CCL2/GYPB/IL6/GYPA/TGFB3/MET	45
KEGG	hsa05012	Parkinson disease	229/6806	266/8135	0.1575	0.2121	0.07753	COX6A2/COX4I2/SLC25A31/COX8C/RYR3/NDUFS7/NDUFS1/UQCRQ/SLC39A12/UQCRB/NDUFC1/ADORA2A/NDUFA1/TUBA1C/NDUFS2/PSMB4/NDUFV2/PSMD6/PARK7/HSPA5/CASP9/ATF4/NDUFB10/CAMK2G/COX5B/SDHB/UBC/NDUFB3/NDUFB11/PSMA6/CALML6/PSMB1/PSMA3/PSMD13/UQCRH/TUBA1B/SLC25A4/NDUFB4/SLC11A2/UBA1/UBE2G1/BAX/GNAI1/CASP3/VDAC2/NDUFA2/SLC39A2/PSMA2/TUBA1A/NDUFA7/NDUFA10/COX7B/PSMC4/SOD1/UQCR10/DAXX/PSMC1/PSMA7/COX8A/HTRA2/SLC39A7/KEAP1/UBE2J1/PSMA5/SLC25A5/PSMD7/TXN/PSMD12/UBE2L3/KLC1/TUBA4A/PSMC6/PSMB3/NDUFB8/XBP1/NDUFS8/NDUFA13/UBE2J2/NFE2L2/COX6B1/PRKACA/PSMD9/PSMD4/UQCRFS1/UQCRC2/SLC39A4/SLC39A13/NDUFB2/DUSP1/NDUFS4/NDUFB6/CALM1/EIF2S1/NDUFA12/ITPR3/COX6B2/PSMA1/PINK1/SDHA/SLC39A3/COX4I1/NDUFA4/CYC1/PSMD1/NDUFA3/UBA7/NDUFV1/UBA52/NDUFA8/PSMB5/PSMC2/TUBA3D/TUBA3E/TUBAL3/TUBB1/NDUFS3/NDUFC2/PSMC5/NDUFA11/CALML4/PSMD11/COX6C/UQCR11/NDUFA9/KLC4/DDIT3/NDUFA6/MAPK9/SDHC/APAF1/SLC39A11/COX7A2/PSMD8/PSMD2/PSMA4/PSMB6/PPIF/NDUFAB1/TUBB/GPR37/PSMC3/GNAI2/CALML5/SLC39A6/PSMB7/TUBA3C/ADRM1/MAP3K5/MFN2/KIF5B/NDUFB7/TRAP1/KIF5C/NDUFB9/GNAI3/GNAS/NDUFV3/TUBA8/NDUFS5/SLC39A8/ATF6/ITPR1/EIF2AK3/SLC39A9/COX5A/PSMD3/CAMK2A/NDUFS6/COX7B2/TXN2/VDAC3/COX6A1/CALML3/NDUFA5/ITPR2/COX7C/DRD1/SLC25A6/SDHD/CAMK2B/MAOA/TUBB6/NDUFB1/CYCS/PRKACB/PRKACG/NDUFB5/PSMB2/CAMK2D/PSMD14/TUBB3/TP53/MAPK8/PSMA8/TH/CALM2/BCL2L1/UQCRC1/KLC3/SLC39A10/PLCG1/UBB/LRRK2/CALM3/RPS27A/MAPK10/SNCAIP/SLC18A2/SLC18A1/DRD2/UBE2L6/NDUFA4L2/KIF5A/VDAC1/SNCA/COX7A2L/ADCY5/MAPT/UCHL1/MAOB/MFN1/KLC2/SLC6A3/SLC39A5/TUBB2B/SLC39A14/GNAL/ERN1/UBE2G2	229
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	18/6806	19/8135	0.1586	0.2127	0.07777	ACY1/IDH3G/ACO2/NAGS/IDH3B/GOT1/CS/GOT1L1/GPT/IDH3A/IDH2/GOT2/IDH1/BCAT1/AADAT/GPT2/BCAT2/ACO1	18
KEGG	hsa04340	Hedgehog signaling pathway	50/6806	56/8135	0.1688	0.2255	0.08242	CSNK1G2/SMURF2/ARRB1/CCND1/GLI2/GLI3/MEGF8/CSNK1E/CUL3/ARRB2/SCUBE2/SUFU/SPOP/PRKACA/MGRN1/SMURF1/IQCE/HHIP/CSNK1G1/CSNK1D/SPOPL/SHH/BTRC/DISP1/EFCAB7/HHATL/GPR161/FBXW11/GSK3B/CUL1/GAS1/CCND2/CSNK1A1/KIF7/PRKACB/PRKACG/KIF3A/BOC/PTCH2/EVC/PTCH1/EVC2/GLI1/HHAT/BCL2/CSNK1G3/CDON/LRP2/DHH/IHH	50
KEGG	hsa03250	Viral life cycle - HIV-1	56/6806	63/8135	0.1702	0.2265	0.08281	BICD1/CHMP4A/PDCD6IP/RAN/VPS4A/TSG101/CD4/CHMP4B/MAP1S/PPIA/CPSF7/NUP153/CHMP6/SUPT4H1/VPS4B/SUPT5H/KAT2B/EP300/APOBEC3C/CPSF6/ELL/TNPO3/HGS/MLLT1/SMARCB1/APOBEC3G/CCNT2/BICD2/FURIN/SAMHD1/APOBEC3F/ELL3/SERINC5/RANBP2/FEZ1/MAP1A/SERINC3/PSIP1/CXCR4/XPO1/PIN1/APOBEC3D/AFF4/MLLT3/APOBEC3A/ELL2/MX2/CCNT1/CREBBP/BST2/KAT2A/CDK9/MX1/MAP1B/CCR5/TRIM5	56
KEGG	hsa04114	Oocyte meiosis	114/6806	131/8135	0.1771	0.2347	0.08581	SPDYA/IGF1/PGR/PPP2CA/PPP2R5D/CAMK2G/PPP2R5C/CALML6/PPP3R2/ANAPC10/MAPK14/ADCY8/MAPK1/ANAPC2/ANAPC7/PTTG2/RPS6KA1/ANAPC1/PRKACA/SLK/PPP1CA/CALM1/ITPR3/RPS6KA3/SMC3/PPP2R1A/FBXO5/MAPK3/MAPK12/ANAPC16/BTRC/PPP1CB/REC8/CDK2/CALML4/PPP2R5B/MAPK13/PKMYT1/MAD1L1/ANAPC5/PTTG1/CDK1/YWHAQ/IGF1R/SMC1B/AURKA/ANAPC13/PPP1CC/CDC27/YWHAE/CALML5/YWHAZ/ADCY6/ANAPC4/CDC26/FBXW11/YWHAH/PPP3CA/YWHAG/SMC1A/CUL1/ITPR1/FBXO43/ANAPC11/PLCZ1/CAMK2A/YWHAB/CALML3/CPEB3/PPP2R5A/MAD2L2/PPP3CB/MAPK11/ITPR2/ADCY9/PPP2R5E/ADCY4/CAMK2B/PPP3CC/CPEB1/RBX1/PRKACB/PRKACG/BUB1/INS/CAMK2D/PPP2CB/SKP1/SPDYE1/CDC16/MOS/CALM2/ADCY7/CDC25C/RPS6KA2/CALM3/PPP3R1/CCNE1/CCNE2/RPS6KA6/CPEB4/AR/CCNB2/ADCY5/CDC23/STAG3/MAP2K1/CPEB2/ADCY3/ADCY1/CCNB1/PLK1/ADCY2/ESPL1	114
KEGG	hsa00061	Fatty acid biosynthesis	17/6806	18/8135	0.1818	0.239	0.08738	MECR/ACSBG2/ACSL3/ACSF3/ACSL4/OXSM/MCAT/ACSL1/CBR4/OLAH/ACSBG1/ACSL5/FASN/ACSL6/HSD17B8/ACACA/ACACB	17
KEGG	hsa00511	Other glycan degradation	17/6806	18/8135	0.1818	0.239	0.08738	GBA2/MAN2B2/GLB1/GBA/MAN2B1/HEXB/AGA/MANBA/FUCA2/HEXA/MAN2C1/NEU1/NEU2/ENGASE/FUCA1/NEU4/NEU3	17
KEGG	hsa01230	Biosynthesis of amino acids	66/6806	75/8135	0.1962	0.257	0.09396	ALDOB/TKTL2/PGAM1/OTC/PGK1/PHGDH/GAPDH/TPI1/ALDOA/ACY1/TALDO1/SDS/TKT/ENO3/PGK2/ENO1/ASL/IDH3G/PRPS1L1/PGAM2/PYCR2/ACO2/MTR/NAGS/PRPS2/ASNS/PFKP/PFKM/PC/IDH3B/PYCR1/GOT1/GLUL/CS/MAT2B/ENO2/GOT1L1/GPT/IDH3A/SHMT2/MAT2A/IDH2/ALDOC/ARG2/ALDH18A1/GOT2/PAH/PKLR/IDH1/RPE/BCAT1/PFKL/SHMT1/PRPS1/CBS/GPT2/BCAT2/ARG1/TKTL1/MAT1A/RPIA/CTH/ASS1/SDSL/ACO1/CPS1	66
KEGG	hsa00590	Arachidonic acid metabolism	54/6806	61/8135	0.1985	0.2589	0.09467	PLA2G2D/GPX5/PTGES2/CYP2C19/PLA2G4D/LTA4H/PTGS1/PTGES3/PTGS2/PLA2G6/PLA2G4C/JMJD7-PLA2G4B/PLA2G4B/GGT1/PLA2G2A/PLA2G4F/PLB1/CYP4F2/GPX7/TBXAS1/ALOX12B/ALOX12/CYP2J2/CYP4F8/CYP2C9/CYP2C8/GPX2/LTC4S/AKR1C3/CYP4F3/PTGDS/ALOX5/CBR3/CBR1/PLA2G4A/ALOX15/PLA2G3/PLA2G12A/EPHX2/PTGIS/GPX1/GGT5/PLA2G2F/CYP2B6/CYP2E1/PLA2G12B/PLA2G10/CYP2U1/PLA2G1B/GPX8/PLA2G2E/PTGES/PLA2G5/GPX3	54
KEGG	hsa00910	Nitrogen metabolism	16/6806	17/8135	0.2079	0.2694	0.09849	GLUD1/CA14/CA5B/GLUD2/CA4/GLUL/CA12/CA9/CA6/CA5A/CA2/CA1/CA13/CA7/CA8/CPS1	16
KEGG	hsa00640	Propanoate metabolism	29/6806	32/8135	0.2089	0.2694	0.09849	LDHAL6B/HADHA/BCKDHA/DLD/SUCLG1/ECHS1/ACADS/ABAT/PCCA/MLYCD/ACSS2/ACOX1/MCEE/BCKDHB/DBT/LDHB/ECHDC1/SUCLA2/LDHAL6A/LDHA/HIBCH/PCCB/ACACA/ACSS3/ACOX3/ACACB/LDHC/SUCLG2/EHHADH	29
KEGG	hsa04136	Autophagy - other	29/6806	32/8135	0.2089	0.2694	0.09849	PIK3C3/PPP2CA/MLST8/RPTOR/ATG5/WIPI2/BECN1/PIK3R4/IGBP1/GABARAPL2/ATG4B/MTOR/ATG4A/ATG12/GABARAP/ATG3/ATG9A/GABARAPL1/ULK2/ATG4D/ATG2A/ATG2B/ATG16L1/ATG7/WIPI1/PPP2CB/ATG9B/ATG4C/ATG10	29
KEGG	hsa00513	Various types of N-glycan biosynthesis	35/6806	39/8135	0.2132	0.2738	0.1001	MGAT4C/MGAT4B/B4GALT1/ALG12/ALG2/ALG3/HEXB/RPN2/B4GALT2/B4GALT3/TUSC3/FUT8/DAD1/HEXA/ALG14/STT3B/MAN1A1/MAN1B1/RPN1/MAN2A2/MGAT4A/MGAT1/B4GALNT4/CHST9/STT3A/ALG9/DDOST/ST3GAL3/MGAT2/ALG13/MAN1C1/B4GALNT3/ALG1/MAN2A1/MAN1A2	35
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	182/6806	212/8135	0.2206	0.2823	0.1032	UGT2B4/UGT2A3/FGF5/CHRNA9/UGT2B17/PGR/CHRNB4/PPARA/AIPL1/CREB3/FGF3/BAD/ATF4/GRB2/ARRB1/CCND1/HSP90B1/MAP2K2/ADCY8/CACNA1C/AIP/GNAI1/PRKCB/CHRNA4/PAQR5/ARRB2/MAPK1/PIK3CB/STAT5B/KPNA6/CHRNA3/BCL6/CACNA1S/GSTA3/RPS6KA1/VDR/ATF6B/PIK3CD/RXRB/PRKACA/AKT3/PTGES3/FGF18/HRAS/STAT5A/GSTO1/RAF1/RPS6KB2/E2F1/EPHX1/EIF4EBP1/RPS6KA3/WNT1/PAQR7/MTOR/MAPK3/PIK3CA/NFKB1/GSTT1/FGF7/PIK3R2/XIAP/RXRA/CYP1A1/FOS/HSP90AB1/FGF6/CHRNB2/MGST3/AKT2/CCND3/PIK3R1/CACNA1F/GNAI2/ADCY6/SOS1/CYP1B1/GNAI3/MIRLET7D/GNAS/JUN/JAK2/AKT1/CHRNA7/MGST1/SOS2/NRAS/FGF16/MYC/KPNB1/KPNA1/UGT1A10/UGT1A7/UGT1A8/ADCY9/ADCY4/VEGFA/CREB3L4/ARNT/FGF17/IKBKE/JAG1/KRAS/CREB3L2/DLL1/RPS6KB1/PRKACB/RB1/PRKACG/ESR2/ADRB2/CREB5/GSTO2/FGF10/CACNA1D/KPNA5/KLF5/KLF4/AHR/CREB3L1/EGF/HSP90AA1/GSTT2/KPNA4/GSTM4/PRKCG/RELA/GSTM3/ADCY7/CYP3A4/DLL4/ATF2/PRKCA/CREB1/FGF4/STAT3/RPS6KA2/UGT2B15/NOTCH2/EPHX3/FGF2/FGF22/SRC/ESR1/FGF20/GSTM1/EPHX2/DLL3/RPS6KA6/KPNA3/KPNA2/FGF9/PIK3R3/PAQR8/AR/CYP2B6/BCL2/MGST2/RXRG/GSTA4/UGT2A1/UGT2A2/CDC6/CACNA1B/GSTM5/GSTM2/ADCY5/CACNA1A/ADRB1/MAP2K1/UGT2B28/NR1I3/ADCY3/ADRB3/FGF8/ADCY1/CYP1A2/CREB3L3/EGFR/BIRC5/ADCY2/CDC25A	182
KEGG	hsa05310	Asthma	28/6806	31/8135	0.2306	0.294	0.1075	CD40/HLA-DRA/TNF/IL4/FCER1G/HLA-DMA/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL3/IL10/HLA-DRB3/HLA-DRB5/EPX/FCER1A/HLA-DOA/IL13/HLA-DPA1/CD40LG/HLA-DPB1/IL9/PRG2/HLA-DOB/HLA-DQA1/HLA-DQA2/CCL11/RNASE3	28
KEGG	hsa05340	Primary immunodeficiency	34/6806	38/8135	0.2332	0.2961	0.1083	CD40/DCLRE1C/IL2RG/BTK/CD4/JAK3/IKBKG/TAP1/RFXAP/ORAI1/CD3D/RAG1/AIRE/CD19/PTPRC/UNG/RFXANK/TNFRSF13B/TAP2/LCK/ICOS/IL7R/ZAP70/CIITA/IGLL1/ADA/CD8B/CD40LG/CD79A/RFX5/BLNK/CD3E/CD8A/RAG2	34
KEGG	hsa00360	Phenylalanine metabolism	15/6806	16/8135	0.2373	0.3003	0.1098	MIF/AOC2/GOT1/GOT1L1/AOC3/GOT2/PAH/MAOA/ALDH3B1/ALDH3B2/IL4I1/ALDH3A1/MAOB/HPD/TAT	15
KEGG	hsa00240	Pyrimidine metabolism	51/6806	58/8135	0.2472	0.3104	0.1135	DHODH/NT5C1B/NME6/ENTPD4/NME1-NME2/NME2/TK2/NME3/UCK1/UPP1/NT5C2/DUT/ENTPD6/CAD/RRM2B/ASMTL/ENTPD5/NT5C/NUDT2/NT5M/HDDC2/CDA/CANT1/DTYMK/ENTPD1/UPB1/ENTPD3/NME4/NT5DC4/UCKL1/ENPP3/DCTPP1/TK1/TYMP/CTPS2/NME1/UPP2/RRM1/DCTD/NT5E/UMPS/DPYS/DPYD/DCK/UCK2/CMPK1/TYMS/RRM2/NME7/NT5C1A/ENPP1	51
KEGG	hsa00480	Glutathione metabolism	51/6806	58/8135	0.2472	0.3104	0.1135	OPLAH/GPX5/SMS/SRM/GGT7/GSTA3/GCLM/GSTO1/GSTK1/G6PD/GSTT1/NAT8B/GGT1/RRM2B/ANPEP/PGD/GSTP1/GSS/GGCT/MGST3/GPX4/CHAC2/ODC1/GSR/GPX7/MGST1/IDH2/GGT6/GPX2/IDH1/GSTO2/GSTT2/GSTM4/GSTM3/RRM1/TXNDC12/GSTM1/GPX1/GGT5/GCLC/LANCL1/MGST2/GSTA4/CHAC1/GSTM5/GSTM2/PRDX6/GPX8/LAP3/RRM2/GPX3	51
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	21/6806	23/8135	0.2498	0.3121	0.1141	GLUD1/PCK1/MDH1/ATP1B3/GLUD2/CA4/GLS/SLC25A10/PCK2/ATP1A1/SLC9A3/FXYD2/SLC38A3/CA2/ATP1B1/GLS2/ATP1A4/ATP1A2/SLC4A4/ATP1A3/ATP1B4	21
KEGG	hsa00270	Cysteine and methionine metabolism	45/6806	51/8135	0.2505	0.3121	0.1141	LDHAL6B/AGXT2/SMS/PHGDH/SRM/AHCY/SDS/MPST/TST/APIP/GCLM/DNMT1/DNMT3A/MDH2/MTR/MDH1/DNMT3B/ENOPH1/AMD1/GSS/GOT1/MAT2B/GOT1L1/MAT2A/MTAP/MRI1/LDHB/GOT2/LDHAL6A/ADI1/BCAT1/LDHA/AHCYL1/BHMT/IL4I1/CBS/BCAT2/GCLC/MAT1A/AHCYL2/BHMT2/LDHC/CTH/SDSL/TAT	45
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	27/6806	30/8135	0.2541	0.3155	0.1153	HAO1/GCSH/DLD/CAT/GLYCTK/ACO2/PGP/MDH2/MDH1/PCCA/GRHPR/ACSS2/MCEE/HYI/GLUL/AFMID/CS/SHMT2/ACAT2/ACAT1/SHMT1/PCCB/HAO2/AGXT/AMT/GLDC/ACO1	27
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	14/6806	15/8135	0.2703	0.3344	0.1222	FUT2/HEXB/GLA/ST3GAL1/A4GALT/GBGT1/HEXA/ST3GAL2/FUT1/FUT9/NAGA/B3GALNT1/B3GALT5/ST8SIA1	14
KEGG	hsa04975	Fat digestion and absorption	38/6806	43/8135	0.2739	0.3376	0.1234	MOGAT3/PNLIP/SLC27A4/PLA2G2D/MTTP/NPC1L1/AGPAT2/DGAT1/APOA1/PLA2G2A/AGPAT1/CD36/ABCA1/DGAT2/SLC27A1/FABP2/ACAT2/ACAT1/GOT2/LIPF/PNLIPRP1/ABCG5/APOA4/APOB/MOGAT2/ABCG8/SCARB1/PLA2G3/PLA2G12A/PLA2G2F/PLA2G12B/PLA2G10/CLPS/PLA2G1B/PLA2G2E/PNLIPRP2/FABP1/PLA2G5	38
KEGG	hsa00340	Histidine metabolism	20/6806	22/8135	0.2783	0.3417	0.1249	CNDP1/ASPA/ALDH9A1/ALDH2/UROC1/HNMT/FTCD/HDC/ALDH1B1/ALDH3A2/ALDH7A1/HAL/MAOA/ALDH3B1/CARNS1/ALDH3B2/CNDP2/AMDHD1/ALDH3A1/MAOB	20
KEGG	hsa00591	Linoleic acid metabolism	26/6806	29/8135	0.2793	0.3417	0.1249	PLA2G2D/CYP2C19/PLA2G4D/PLA2G6/PLA2G4C/JMJD7-PLA2G4B/PLA2G4B/PLA2G2A/PLA2G4F/PLB1/CYP2J2/CYP2C9/CYP2C8/PLA2G4A/CYP3A4/ALOX15/PLA2G3/PLA2G12A/PLA2G2F/CYP2E1/PLA2G12B/PLA2G10/PLA2G1B/PLA2G2E/PLA2G5/CYP1A2	26
KEGG	hsa04914	Progesterone-mediated oocyte maturation	88/6806	102/8135	0.2867	0.3495	0.1278	SPDYA/CCNB3/IGF1/PGR/ANAPC10/STK10/MAPK14/ADCY8/GNAI1/MAPK1/ANAPC2/PIK3CB/ARAF/ANAPC7/RPS6KA1/ANAPC1/PIK3CD/PRKACA/AKT3/RAF1/RPS6KA3/KIF22/MAPK3/PIK3CA/MAPK12/ANAPC16/CDK2/PIK3R2/MAPK13/PKMYT1/MAPK9/HSP90AB1/MAD1L1/ANAPC5/CDK1/IGF1R/AURKA/ANAPC13/CDC27/AKT2/PIK3R1/GNAI2/ADCY6/ANAPC4/FZR1/CDC26/GNAI3/CDC25B/AKT1/ANAPC11/CPEB3/MAD2L2/MAPK11/ADCY9/ADCY4/CPEB1/KRAS/PRKACB/PRKACG/BUB1/BRAF/INS/PDE3B/MAPK8/SPDYE1/CDC16/CCNA2/HSP90AA1/MOS/ADCY7/CDC25C/RPS6KA2/RPS6KA6/MAPK10/CPEB4/PIK3R3/CCNB2/ADCY5/CDC23/MAP2K1/CPEB2/ADCY3/ADCY1/CCNB1/PLK1/CCNA1/ADCY2/CDC25A	88
KEGG	hsa04672	Intestinal immune network for IgA production	43/6806	49/8135	0.2901	0.3523	0.1288	IL2/CCL25/CD40/TGFB1/LTBR/HLA-DRA/ITGA4/TNFSF13/CCL28/IL4/HLA-DMA/TNFRSF13B/IL15/ITGB7/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL10/CD86/HLA-DRB3/HLA-DRB5/ICOS/MAP3K14/CXCR4/HLA-DOA/CCR10/HLA-DPA1/MADCAM1/CD40LG/CD28/IL15RA/HLA-DPB1/TNFSF13B/CD80/ICOSLG/HLA-DOB/HLA-DQA1/HLA-DQA2/IL6/CXCL12/CCR9/PIGR	43
KEGG	hsa00380	Tryptophan metabolism	37/6806	42/8135	0.296	0.3582	0.1309	TPH2/TDO2/HADHA/AOX1/DLD/HADH/CAT/ALDH9A1/ECHS1/ALDH2/GCDH/HAAO/CYP1A1/AFMID/DLST/KYNU/ALDH1B1/CYP1B1/ACMSD/ALDH3A2/DHTKD1/ALDH7A1/ACAT2/ACAT1/MAOA/ASMT/AADAT/IL4I1/IDO1/ALDH8A1/INMT/MAOB/KMO/AANAT/CYP1A2/IDO2/EHHADH	37
KEGG	hsa00650	Butanoate metabolism	25/6806	28/8135	0.3063	0.3694	0.135	HADHA/HMGCL/ACSM1/HADH/ECHS1/AACS/ACADS/ACSM5/ABAT/HMGCS1/OXCT2/HMGCS2/OXCT1/ACAT2/ACAT1/ACSM2A/ACSM2B/BDH1/GAD2/L2HGDH/ALDH5A1/GAD1/ACSM3/EHHADH/BDH2	25
KEGG	hsa00670	One carbon pool by folate	18/6806	20/8135	0.3427	0.4117	0.1505	MTR/ALDH1L1/DHFR/MTFMT/MTHFD2L/FTCD/ATIC/MTHFR/SHMT2/MTHFS/MTHFD1/MTHFD1L/SHMT1/ALDH1L2/AMT/MTHFD2/TYMS/GART	18
KEGG	hsa03450	Non-homologous end-joining	12/6806	13/8135	0.3479	0.4165	0.1523	DCLRE1C/XRCC5/RAD50/FEN1/XRCC6/LIG4/POLL/POLM/XRCC4/PRKDC/DNTT/NHEJ1	12
KEGG	hsa00051	Fructose and mannose metabolism	29/6806	33/8135	0.3542	0.4225	0.1545	ALDOB/MPI/TPI1/ALDOA/SORD/PMM1/GMDS/FBP1/HK3/GMPPB/GMPPA/KHK/PFKP/PFKM/AKR1B1/TSTA3/PMM2/FPGT/HK2/HKDC1/ALDOC/PFKFB4/PFKFB2/PFKL/PFKFB3/HK1/AKR1B10/FBP2/ENOSF1	29
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	189/6806	223/8135	0.3679	0.4373	0.1599	COX6A2/COX4I2/SLC25A31/NOX1/COX8C/NDUFS7/NDUFS1/UQCRQ/UQCRB/NDUFC1/NDUFA1/NDUFS2/NDUFV2/BAD/NDUFB10/PTPN1/GRB2/COX5B/SDHB/NDUFB3/RAC1/NDUFB11/AKR1A1/MAP2K2/AKR1C4/UQCRH/SLC25A4/MAPK14/NDUFB4/ABL2/VDAC2/NDUFA2/CAT/NDUFA7/NDUFA10/COX7B/SOD1/UQCR10/COX8A/MAPK1/PIK3CB/ARAF/KEAP1/SLC25A5/NCF1/GSTA3/NDUFB8/NDUFS8/NDUFA13/IKBKG/NFE2L2/COX6B1/PIK3CD/AKT3/UQCRFS1/UQCRC2/HRAS/NDUFB2/GSTO1/SLC26A6/RAF1/NCF2/NDUFS4/NDUFB6/NDUFA12/COX6B2/NFKBIA/EPHX1/SDHA/COX4I1/NDUFA4/CYC1/PLD1/AKR1C2/NDUFA3/NDUFV1/LPO/PRKCD/PRKD2/MAPK3/NQO1/PIK3CA/PLD2/NFKB1/NDUFA8/GSTT1/MAPK12/PTEN/NDUFS3/ACP1/NDUFC2/MAP2K4/NDUFA11/COX6C/UQCR11/PIK3R2/NDUFA9/NDUFA6/CYP1A1/FOS/MAPK13/MAPK9/IKBKB/SDHC/COX7A2/AS3MT/CYP2F1/PPIF/CYBA/NDUFAB1/MGST3/AKT2/PIK3R1/MAP3K5/SOS1/CYP1B1/NDUFB7/NDUFB9/SOD2/JUN/NDUFV3/NDUFS5/AKT1/MGST1/SOS2/NRAS/HGF/COX5A/ABL1/NDUFS6/COX7B2/VDAC3/COX6A1/NDUFA5/HMOX1/MAPK11/COX7C/NOX4/CHUK/VEGFA/SLC25A6/SDHD/ARNT/PTPRJ/NDUFB1/MAP3K14/KRAS/AKR1C3/NDUFB5/PTK2/SLC26A1/HIF1A/PDPK1/BRAF/GSTO2/CBR1/MAP2K7/MAPK8/AHR/PRKD1/EGF/GSTT2/GSTM4/RELA/UQCRC1/GSTM3/SLC26A2/FOXO3/EPHX3/SRC/GSTM1/EPHX2/MAPK10/PIK3R3/SLC26A9/MGST2/CYP2E1/NDUFA4L2/GSTA4/VDAC1/PRKD3/PTPN11/GSTM5/COX7A2L/GSTM2/MAP2K1/CYP1A2/EGFR/MET	189
KEGG	hsa05100	Bacterial invasion of epithelial cells	66/6806	77/8135	0.381	0.4512	0.165	ARPC1A/ITGA5/RAC1/ACTG1/CRKL/RHOA/ARPC4/ACTR2/ARPC1B/PIK3CB/ILK/ELMO1/VCL/ELMO2/CLTA/BCAR1/WASL/PIK3CD/ARPC2/SHC1/CTNNA1/CLTC/SHC3/ARPC5/CLTB/ARPC3/PXN/PIK3CA/RHOG/ACTR3B/ARPC5L/ACTB/PIK3R2/CDC42/CLTCL1/DNM2/ELMO3/PIK3R1/HCLS1/DNM1/ACTR3/ARHGAP10/CRK/MAD2L2/CTTN/CD2AP/ITGB1/PTK2/WASF2/CTNNB1/CTNNA3/SHC4/SRC/CTNNA2/PIK3R3/DOCK1/FN1/CAV2/CDH1/CBL/WASF1/ACTR3C/CAV1/SHC2/GAB1/MET	66
KEGG	hsa00330	Arginine and proline metabolism	44/6806	51/8135	0.3911	0.4616	0.1688	CNDP1/SMS/SRM/P4HA1/OAT/DAO/ALDH9A1/ALDH2/PYCR2/PRODH/P4HA2/SAT1/AMD1/NOS3/PYCR1/GOT1/ALDH4A1/GOT1L1/CKMT2/ALDH1B1/GAMT/ODC1/ALDH3A2/PRODH2/SAT2/ARG2/ALDH18A1/ALDH7A1/GOT2/MAOA/AGMAT/CARNS1/SMOX/CNDP2/CKM/ARG1/MAOB/NOS2/NOS1/LAP3/CKMT1A/CKMT1B/P4HA3/CKB	44
KEGG	hsa04976	Bile secretion	76/6806	89/8135	0.3935	0.4628	0.1692	CYP7A1/UGT2B4/UGT2A3/UGT2B17/SLCO1B3/SLC10A2/NCEH1/KCNN2/ABCB11/ADCY8/CFTR/PRKACA/HMGCR/EPHX1/SLC22A8/SLC9A1/ATP1B3/SLC4A5/RXRA/SLC22A7/SLC4A2/AQP8/ADCY6/SLC27A5/LDLR/GNAS/ABCB1/ABCB4/ABCC4/UGT1A10/UGT1A7/UGT1A8/ADCY9/ADCY4/SULT2A1/ATP1A1/SLC9A3/ABCC2/SLC22A1/PRKACB/PRKACG/SLCO1B1/NR1H4/NR0B2/FXYD2/SLC10A1/ABCG5/AQP9/SLCO1A2/SCT/ABCC3/ADCY7/CYP3A4/SLC2A1/ABCG8/CA2/UGT2B15/SCARB1/ATP1B1/UGT2A1/UGT2A2/ABCG2/ATP1A4/SLC5A1/ADCY5/ATP1A2/AQP4/SLC4A4/ATP1A3/ATP1B4/UGT2B28/ADCY3/ADCY1/ADCY2/BAAT/SCTR	76
KEGG	hsa00592	alpha-Linolenic acid metabolism	22/6806	25/8135	0.3983	0.4667	0.1706	PLA2G2D/ACAA1/PLA2G4D/PLA2G6/FADS2/PLA2G4C/JMJD7-PLA2G4B/PLA2G4B/ACOX1/PLA2G2A/PLA2G4F/PLB1/PLA2G4A/PLA2G3/PLA2G12A/ACOX3/PLA2G2F/PLA2G12B/PLA2G10/PLA2G1B/PLA2G2E/PLA2G5	22
KEGG	hsa04977	Vitamin digestion and absorption	21/6806	24/8135	0.4324	0.5049	0.1846	PNLIP/LRAT/TCN2/LMBRD1/BTD/ABCC1/SLC19A1/APOA1/PLB1/RBP2/SLC5A6/SLC46A1/APOA4/SLC23A1/APOB/SLC19A2/CUBN/FOLH1/SCARB1/SLC19A3/MMACHC	21
KEGG	hsa00565	Ether lipid metabolism	42/6806	49/8135	0.4392	0.5111	0.1869	PLA2G2D/PLD4/GDPD1/PAFAH2/PLA2G4D/LPCAT4/PLD3/ENPP6/PAFAH1B3/CEPT1/PAFAH1B2/GDPD3/PLA2G6/PLD1/PLA2G4C/PLD2/JMJD7-PLA2G4B/PLA2G4B/TMEM189/TMEM189-UBE2V1/LPCAT2/PLA2G2A/PLA2G4F/PLB1/TMEM86B/PLA2G7/GAL3ST1/CHPT1/UGT8/AGPS/LPCAT1/ENPP2/PLA2G4A/PLA2G3/PLA2G12A/PLA2G2F/PAFAH1B1/PLA2G12B/PLA2G10/PLA2G1B/PLA2G2E/PLA2G5	42
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	31/6806	36/8135	0.4517	0.5238	0.1915	SIRT2/AOX1/NT5C1B/SIRT7/NNMT/NADSYN1/SIRT4/NT5C2/NT5C/NT5M/NADK/SIRT3/SIRT6/NNT/SIRT1/BST1/PNP/NT5DC4/NAMPT/SIRT5/ENPP3/ASPDH/QPRT/NT5E/CD38/NMNAT2/NMNAT1/NMNAT3/NT5C1A/ENPP1/NUDT12	31
KEGG	hsa00564	Glycerophospholipid metabolism	83/6806	98/8135	0.4561	0.5272	0.1927	PLA2G2D/PLD4/ETNK2/PEMT/PLA2G4D/LPCAT4/GNPAT/PLD3/PGS1/CEPT1/MBOAT7/PCYT2/PLA2G15/LPCAT3/MBOAT2/PLA2G6/PHOSPHO1/GPCPD1/PLD1/AGPAT3/PLA2G4C/DGKD/AGPAT2/PLD2/CDS2/JMJD7-PLA2G4B/PLA2G4B/PISD/MBOAT1/LYPLA2/CDIPT/GPD2/DGKQ/GPD1L/LPCAT2/PLA2G2A/LPGAT1/PNPLA6/PLA2G4F/PLB1/PNPLA7/AGPAT1/DGKE/LYPLA1/LCLAT1/LPIN3/LCAT/PTDSS2/DGKI/PCYT1A/DGKA/PCYT1B/DGKZ/LPIN2/CDS1/ETNK1/GPD1/CHPT1/CHKB/PTDSS1/LPCAT1/GPAT2/PLA2G4A/DGKG/TAZ/LPIN1/PLA2G3/PLA2G12A/CHKA/PLA1A/PLA2G2F/AGPAT4/GPAM/PLA2G12B/PLA2G10/DGKB/PLA2G1B/PLA2G2E/CRLS1/PLA2G5/CHAT/AGPAT5/ACHE	83
KEGG	hsa04392	Hippo signaling pathway - multiple species	25/6806	29/8135	0.4753	0.5474	0.2001	FAT4/CSNK1E/PAK1/RASSF1/WTIP/RASSF4/LIMD1/RASSF2/LATS2/TEAD2/NF2/FRMD6/TEAD4/WWC1/TEAD1/DCHS2/DCHS1/STK3/YAP1/RASSF6/SAV1/TEAD3/FRMD1/LATS1/WWTR1	25
KEGG	hsa00920	Sulfur metabolism	9/6806	10/8135	0.496	0.5693	0.2081	MPST/TST/PAPSS2/PAPSS1/IMPAD1/ETHE1/SELENBP1/SUOX/BPNT1	9
KEGG	hsa00430	Taurine and hypotaurine metabolism	14/6806	16/8135	0.5011	0.5732	0.2096	FMO3/GGT7/GGT1/CSAD/GGT6/FMO2/FMO1/GAD2/GAD1/ADO/GGT5/GADL1/FMO5/BAAT	14
KEGG	hsa00260	Glycine, serine and threonine metabolism	34/6806	40/8135	0.5135	0.5853	0.214	GCAT/AGXT2/PGAM1/GCSH/PHGDH/DLD/SDS/DAO/PGAM2/GLYCTK/GNMT/ALAS1/GRHPR/AOC2/AOC3/GAMT/SHMT2/SARDH/ALDH7A1/MAOA/DMGDH/SHMT1/SRR/BHMT/CBS/AGXT/PIPOX/AMT/BPGM/ALAS2/MAOB/CTH/GLDC/SDSL	34
KEGG	hsa05415	Diabetic cardiomyopathy	170/6806	203/8135	0.5339	0.6065	0.2217	GYS2/COX6A2/COX4I2/SLC25A31/COX8C/NDUFS7/NDUFS1/UQCRQ/UQCRB/NDUFC1/NDUFA1/NDUFS2/NDUFV2/PPARA/NDUFB10/CAMK2G/COX5B/SDHB/TGFB1/NDUFB3/RAC1/NDUFB11/GAPDH/TGFB2/PDHA2/UQCRH/PLCB2/SLC25A4/MAPK14/NCF4/NDUFB4/VDAC2/PRKCB/NDUFA2/NDUFA7/NDUFA10/COX7B/UQCR10/COX8A/PIK3CB/SLC25A5/NCF1/NDUFB8/NDUFS8/NDUFA13/COX6B1/PIK3CD/AKT3/UQCRFS1/UQCRC2/PPP1CA/NDUFB2/ATP2A2/NCF2/NDUFS4/NDUFB6/NDUFA12/COX6B2/SDHA/RAC2/PDK3/COX4I1/NDUFA4/CYC1/CPT2/GFPT2/MTOR/NDUFA3/G6PD/NDUFV1/PRKCD/PIK3CA/NFKB1/NDUFA8/ATP2A3/MAPK12/CMA1/REN/PTEN/SMAD3/NDUFS3/PPP1CB/NDUFC2/NDUFA11/COX6C/UQCR11/PIK3R2/NDUFA9/NDUFA6/MAPK13/MAPK9/SDHC/COX7A2/PARP1/NOS3/GYS1/PPIF/CYBA/NDUFAB1/PPP1CC/AKT2/TGFBR2/AGER/PIK3R1/CD36/SMAD2/CYBB/NDUFB7/NDUFB9/PDK2/PDHA1/GSK3B/CTSD/NDUFV3/PRKCZ/PLCB4/GSR/NDUFS5/AKT1/AGTR1/PDHB/COX5A/CAMK2A/NDUFS6/COX7B2/VDAC3/COX6A1/NDUFA5/MAPK11/COX7C/IRS1/SLC25A6/SDHD/CAMK2B/MMP9/NDUFB1/PLCB3/NDUFB5/INS/CAMK2D/MAPK8/PLN/INSR/GFPT1/PLCB1/PRKCG/RELA/UQCRC1/COL1A1/SLC2A1/MMP2/PRKCA/CPT1B/TGFBR1/MAPK10/PIK3R3/NDUFA4L2/ACE/RYR2/VDAC1/PDK4/COX7A2L/TBC1D4/SP1/TGFB3/COL3A1/AGT/TNNI3/SLC2A4/COL1A2	170
KEGG	hsa00062	Fatty acid elongation	23/6806	27/8135	0.5421	0.6117	0.2236	PPT2/ELOVL2/HADHA/MECR/HADHB/HADH/ELOVL1/ECHS1/ACAA2/ELOVL5/TECR/PPT1/ACOT7/HSD17B12/ACOT1/ACOT2/ELOVL4/THEM4/ELOVL3/ELOVL7/THEM5/ELOVL6/ACOT4	23
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	23/6806	27/8135	0.5421	0.6117	0.2236	ELOVL2/ACAA1/ELOVL1/ELOVL5/TECR/FADS2/HSD17B4/ACOT7/HSD17B12/ACOX1/ACOT1/ACOT2/ELOVL4/SCP2/FADS1/ELOVL3/ELOVL7/SCD5/ELOVL6/ACOX3/SCD/BAAT/ACOT4	23
KEGG	hsa04742	Taste transduction	72/6806	86/8135	0.565	0.6333	0.2315	GABRA6/TAS2R13/GNG13/TAS2R8/TAS2R19/TAS2R16/HTR1D/GABRA4/TAS1R2/TAS2R1/P2RY4/PDE1A/GABRA2/TAS2R41/TAS2R9/TAS2R50/GNAT3/PLCB2/ADCY8/CACNA1C/TAS2R4/TAS2R7/CHRM3/ENTPD2/PRKACA/ITPR3/TAS2R40/TAS2R45/TAS2R39/SCNN1B/TAS2R3/SCNN1A/ADCY6/PDE1B/TAS2R10/GABBR1/P2RX3/GNB3/PLCB4/GRM4/GABRA1/HTR1F/ADCY4/HTR3C/PLCB3/PRKACB/PRKACG/SCN2A/HTR3B/HTR1A/PLCB1/GABRA3/TAS2R14/HTR1B/HTR1E/GABBR2/SCNN1G/HCN4/TAS1R1/SCN9A/CACNA1A/P2RX2/GABRA5/TRPM5/GRM1/PKD2L1/PDE1C/KCNK5/CALHM1/TAS2R5/SCN3A/HTR3A	72
KEGG	hsa00983	Drug metabolism - other enzymes	67/6806	80/8135	0.565	0.6333	0.2315	UGT2B4/UGT2A3/CYP2A7/UGT2B17/NAT2/GUSB/ITPA/NME6/GMPS/GSTA3/NME1-NME2/NME2/TK2/NME3/UCK1/GSTO1/NAT1/UPP1/TPMT/DUT/GSTT1/RRM2B/CES2/GSTP1/CDA/HPRT1/MGST3/UPB1/XDH/MGST1/IMPDH2/NME4/IMPDH1/UGT1A10/UGT1A7/UGT1A8/UCKL1/TK1/TYMP/GSTO2/NME1/CYP2A6/CES1/GSTT2/GSTM4/UPP2/GSTM3/CYP3A4/RRM1/UGT2B15/GSTM1/UMPS/DPYS/MPO/DPYD/MGST2/CYP2E1/GSTA4/UGT2A1/UGT2A2/UCK2/GSTM5/GSTM2/UGT2B28/CMPK1/RRM2/NME7	67
KEGG	hsa00790	Folate biosynthesis	22/6806	26/8135	0.5766	0.6419	0.2347	TPH2/ALPP/PCBD1/DHFR/AKR1B1/ALPL/SPR/PAH/AKR1C3/GGH/CBR1/ALPI/PTS/TH/AKR1B10/GPHN/QDPR/PCBD2/MOCS2/GCH1/MOCOS/FPGS	22
KEGG	hsa04950	Maturity onset diabetes of the young	22/6806	26/8135	0.5766	0.6419	0.2347	RFX6/SLC2A2/HNF4G/NKX2-2/NKX6-1/HNF1A/HNF4A/GCK/HHEX/NEUROD1/HES1/PAX4/PKLR/INS/PDX1/ONECUT1/IAPP/MNX1/FOXA3/NR5A2/PAX6/HNF1B	22
KEGG	hsa01232	Nucleotide metabolism	70/6806	85/8135	0.6917	0.7675	0.2806	NT5C1B/ADSL/ITPA/NME6/GMPS/DGUOK/ENTPD4/NME1-NME2/NME2/TK2/ENTPD2/NME3/UCK1/AMPD2/AK2/UPP1/NUDT16/NT5C2/APRT/DUT/ENTPD6/RRM2B/ASMTL/ENTPD5/NT5C/NT5M/HDDC2/CDA/GMPR2/AK1/CANT1/AMPD3/GUK1/HPRT1/DTYMK/ENTPD1/XDH/IMPDH2/ENTPD3/NME4/IMPDH1/PNP/NT5DC4/UCKL1/AK3/AMPD1/ENPP3/GDA/DCTPP1/TK1/GMPR/TYMP/ADK/AK5/CTPS2/NME1/UPP2/RRM1/AK7/DCTD/ADA/NT5E/DCK/UCK2/CMPK1/TYMS/RRM2/NME7/NT5C1A/ENPP1	70
KEGG	hsa00450	Selenocompound metabolism	14/6806	17/8135	0.7023	0.7768	0.284	TXNRD1/SEPHS1/MTR/PAPSS2/SEPSECS/PAPSS1/TXNRD2/SCLY/PSTK/SEPHS2/MARS2/INMT/TXNRD3/CTH	14
KEGG	hsa01240	Biosynthesis of cofactors	126/6806	153/8135	0.7154	0.7886	0.2883	UGT2B4/UGT2A3/TDO2/UGT2B17/PPCS/ALPP/COASY/MPI/AKR1A1/DHODH/VKORC1/NFS1/GUSB/ADSL/DLD/COQ7/PDXP/UGP2/PPOX/PMM1/LIPT1/NME6/NME1-NME2/NME2/GCLM/ALDH2/GMPPB/NME3/NADSYN1/AK2/PPCDC/GMPPA/DHFR/UROD/NQO1/DHRS3/CAD/MTHFD2L/FLAD1/COQ5/HAAO/ALAS1/OXSM/UROS/NADK/AK1/ALAD/GSS/PANK2/PDXK/VKORC1L1/COQ2/AFMID/KYNU/MAT2B/COQ6/ALPL/ALDH1B1/GGCX/SHMT2/MAT2A/PMM2/ALDH3A2/NME4/RDH11/COX15/SPR/UGT1A10/UGT1A7/UGT1A8/MTHFD1/EARS2/AK3/MTHFD1L/RFK/RDH12/COQ3/HSD17B6/ASPDH/BCAT1/AK5/CTPS2/HMBS/RGN/GGH/NME1/ALPI/COX10/PTS/SHMT1/CPOX/AK7/QPRT/PANK3/UGT2B15/BCAT2/GPHN/UMPS/SDR16C5/MMAB/GCLC/NMNAT2/NMNAT1/IDO1/UGT2A1/UGT2A2/MAT1A/TPK1/PANK1/NMNAT3/ALAS2/UGT2B28/KMO/CMPK1/MTHFD2/MOCS2/GCH1/HPD/LIAS/RDH13/UGDH/IDO2/NME7/PHOSPHO2/FECH/FPGS	126
KEGG	hsa03010	Ribosome	130/6806	158/8135	0.7255	0.7971	0.2914	MRPL34/MRPL33/RPL36AL/RPL19/MRPS15/RPL31/RPL32/MRPS5/MRPL17/RPL30/MRPS2/RPS2/RPL34/RPL38/MRPL14/MRPL23/RPS21/RPL23A/MRPL19/RPL35A/RPL12/RPS23/RPL17/RPS17/RPL26/RPL24/FAU/RPS12/RPL28/RPL37A/MRPS6/RPS24/MRPS11/RPLP0/RPS7/MRPL18/RPL41/RPL6/RPL7A/RPL29/RPL4/RPL3/MRPL28/MRPL3/MRPL12/RPS15/MRPL11/RPL18/RPL21/MRPL16/MRPL15/RPL36/MRPS16/RPS13/MRPS10/RPL27A/RPL10/RPS19/RPL14/RPS15A/RPL37/RPS27L/RPLP1/UBA52/MRPL4/MRPS14/RPSA/RPL13A/MRPS7/MRPS9/RPL8/MRPL24/RPL7/RPS14/RPS5/RPL35/MRPL20/RPL26L1/MRPL1/RPL13/RPS11/MRPS17/MRPL36/RPL15/MRPL9/MRPL32/RPS10/MRPS12/MRPL35/RPS27/RPLP2/RPS8/RPS9/MRPL21/MRPS18C/RPS28/MRPL2/MRPS18A/RPL5/RPS4X/RPL22/RPS18/RPS3/RPL36A/RPL39/RPS3A/RPL10L/MRPL30/RPS29/RPS6/RPL11/RPL23/RPS16/MRPL13/RPL27/MRPL10/RPL10A/RPS20/RPS25/MRPL22/MRPS21/RPS26/RPL22L1/RPL9/MRPL27/RPS27A/RSL24D1/RPL18A/RPL3L/RPS4Y1	130
KEGG	hsa00512	Mucin type O-glycan biosynthesis	29/6806	36/8135	0.775	0.8486	0.3102	GALNTL6/B3GNT3/GALNT7/GCNT1/GALNT10/C1GALT1C1/GALNT9/ST3GAL1/GALNT1/GALNT2/ST6GALNAC2/ST3GAL2/GALNT4/GALNTL5/GALNT3/GALNT12/GCNT4/GALNT6/ST6GALNAC4/C1GALT1/GALNT11/GALNT14/B4GALT5/GALNT13/GALNT8/GCNT3/B3GNT6/GALNT5/ST6GALNAC3	29
KEGG	hsa00600	Sphingolipid metabolism	42/6806	52/8135	0.7802	0.8494	0.3105	B4GALNT1/SMPD2/GBA2/ASAH2/GALC/PSAP/GLB1/SPTLC3/GBA/CERK/HEXB/GLA/ARSA/SMPD1/HEXA/SMPD4/SPTLC1/SGMS1/SGPL1/B4GALT6/NEU1/DEGS1/SPTLC2/NEU2/ACER3/GAL3ST1/SPHK2/UGT8/SGMS2/NEU4/SMPD3/UGCG/DEGS2/SPHK1/SGPP1/ASAH1/KDSR/NEU3/SGPP2/ACER1/PSAPL1/ENPP7	42
KEGG	hsa00100	Steroid biosynthesis	16/6806	20/8135	0.7816	0.8494	0.3105	CYP24A1/SOAT1/EBP/FDFT1/LIPA/TM7SF2/HSD17B7/LSS/CYP27B1/NSDHL/CYP2R1/SOAT2/CYP51A1/LBR/SQLE/DHCR24	16
KEGG	hsa03440	Homologous recombination	33/6806	41/8135	0.7833	0.8494	0.3105	BRIP1/BRCC3/MUS81/RAD50/POLD3/RPA3/NBN/XRCC3/SSBP1/UIMC1/ATM/POLD4/TOPBP1/BRCA1/POLD1/RPA2/RAD52/RAD54B/SYCP3/BLM/RAD51/EME1/POLD2/TOP3A/RAD51C/RAD54L/RPA1/XRCC2/RBBP8/PALB2/BRCA2/BARD1/TOP3B	33
KEGG	hsa00830	Retinol metabolism	55/6806	68/8135	0.7887	0.8525	0.3117	ALDH1A3/UGT2B4/UGT2A3/CYP2A7/ADH1B/LRAT/UGT2B17/ADH7/PNPLA4/CYP2S1/AOX1/ADH5/ADH1A/RETSAT/DHRS3/DGAT1/DHRS4/DHRS4L2/CYP1A1/RPE65/RDH5/CYP2C18/RDH10/RDH11/UGT1A10/UGT1A7/UGT1A8/DHRS9/CYP2C9/CYP2C8/CYP26A1/RDH12/CYP2W1/HSD17B6/CYP2A6/RDH8/CYP3A4/ALDH1A1/CYP3A7/CYP27C1/UGT2B15/ADH4/SDR16C5/CYP2B6/UGT2A1/UGT2A2/ALDH1A2/CYP3A5/ADH1C/UGT2B28/RDH16/CYP26B1/RDH13/CYP1A2/ADH6	55
KEGG	hsa00140	Steroid hormone biosynthesis	49/6806	61/8135	0.8135	0.8736	0.3194	CYP7A1/UGT2B4/UGT2A3/HSD17B2/UGT2B17/CYP7B1/HSD17B1/AKR1C4/AKR1D1/COMT/AKR1C2/HSD11B1/CYP11A1/CYP1A1/HSD17B12/CYP11B2/HSD3B2/CYP1B1/HSD17B7/STS/HSD3B1/UGT1A10/UGT1A7/UGT1A8/SULT1E1/AKR1C3/HSD17B6/CYP21A2/LRTOMT/HSD17B8/SRD5A2/CYP3A4/SRD5A3/CYP3A7/UGT2B15/CYP11B1/CYP17A1/CYP19A1/SULT2B1/CYP2E1/UGT2A1/UGT2A2/CYP3A5/UGT2B28/HSD11B2/SRD5A1/CYP1A2/HSD17B3/DHRS11	49
KEGG	hsa00561	Glycerolipid metabolism	49/6806	61/8135	0.8135	0.8736	0.3194	MOGAT3/PNLIP/LIPG/AKR1A1/PNPLA2/ALDH9A1/GLA/ALDH2/GLYCTK/MBOAT2/AGPAT3/DGKD/AGPAT2/DGAT1/GK2/MBOAT1/MGLL/DGKQ/AKR1B1/AGPAT1/ALDH1B1/DGKE/ALDH3A2/LCLAT1/GK/DGAT2/LPIN3/ALDH7A1/DGKI/AGK/DGKA/LIPF/DGKZ/LPIN2/PNLIPRP1/GPAT2/MOGAT2/DGKG/PNPLA3/PNLIPRP3/LPIN1/AKR1B10/AGPAT4/GPAM/DGKB/PNLIPRP2/LPL/AGPAT5/LIPC	49
KEGG	hsa03460	Fanconi anemia pathway	43/6806	54/8135	0.8395	0.8987	0.3285	BRIP1/UBE2T/FANCM/TELO2/PMS2/REV1/FANCA/MUS81/ERCC1/POLH/POLI/RPA3/FANCE/USP1/FANCG/MLH1/WDR48/ERCC4/BRCA1/RPA2/HES1/POLK/EME2/BLM/RAD51/EME1/POLN/TOP3A/FANCF/ATR/RAD51C/ATRIP/RPA1/FANCL/FANCD2/RMI1/PALB2/BRCA2/FANCB/FANCC/FANCI/REV3L/TOP3B	43
KEGG	hsa04714	Thermogenesis	188/6806	232/8135	0.8814	0.9389	0.3433	COX6A2/COX4I2/KLB/COX8C/NDUFS7/NDUFS1/UQCRQ/UQCRB/NDUFC1/NDUFA1/NDUFS2/NDUFV2/CREB3/NDUFB10/GRB2/PRKG2/COX5B/MLST8/SDHB/SMARCD1/NDUFB3/COX17/RPTOR/NDUFB11/ARID1A/GCG/ACTG1/CPT1C/UQCRH/NPPA/MAPK14/ADCY8/NDUFB4/NDUFA2/TSC2/TSC1/NDUFA7/NDUFA10/COX7B/UQCR10/COX8A/SLC25A20/BMP8A/CPT1A/PNPLA2/AKT1S1/NDUFB8/NDUFS8/NDUFAF3/RHEB/NDUFA13/RPS6KA1/SMARCC1/COX6B1/PRKACA/UQCRFS1/UQCRC2/HRAS/NDUFB2/NDUFS4/NDUFB6/KDM3A/RPS6KB2/NDUFA12/PRKAB1/COX6B2/RPS6KA3/SDHA/COX4I1/NDUFA4/CYC1/CPT2/ACSL3/MTOR/NDUFA3/NDUFV1/DPF1/NDUFA8/MAPK12/SLC25A29/SMARCD3/NDUFS3/SMARCB1/NDUFC2/ACTB/ACSL4/MGLL/NDUFA11/COX6C/UQCR11/NDUFA9/ZNF516/NDUFA6/NPR1/MAPK13/PLIN1/SDHC/COX7A2/SMARCA4/KDM1A/PRKAG2/SIRT6/NDUFAB1/ACSL1/ADCY6/MAP3K5/KDM3B/SMARCC2/SOS1/NDUFB7/NDUFB9/GNAS/COX11/NDUFV3/NDUFAF2/NDUFS5/SOS2/NRAS/COX18/SMARCD2/PRKAA1/COX5A/PRDM16/NDUFAF4/NDUFS6/COX7B2/COX6A1/COX15/NDUFA5/MAPK11/COX7C/ADCY9/COX19/ADCY4/RPS6/CREB3L4/SDHD/UCP1/PRKAG1/SMARCA2/NDUFB1/KRAS/CREB3L2/RPS6KB1/PRKACB/PRKACG/NDUFB5/COX16/NDUFAF1/CREB5/ACSL5/COX10/FRS2/ACSL6/CREB3L1/SMARCE1/UQCRC1/ADCY7/ATF2/BMP8B/CREB1/RPS6KA2/CPT1B/RPS6KA6/ACTL6B/ARID1B/ACTL6A/PRKAG3/NDUFA4L2/PRKG1/MAP2K3/PRKAB2/FGFR1/COX7A2L/ADCY5/ADCY10/PRKAA2/ADCY3/NPPB/ADRB3/ADCY1/CNR1/CREB3L3/ADCY2/PPARG/LIPE/DPF3/PPARGC1A	188
KEGG	hsa04217	Necroptosis	128/6806	159/8135	0.8827	0.9389	0.3433	IL33/IFNA2/IFNB1/IFNA1/IFNA13/SLC25A31/CHMP4A/CAMK2G/SPATA2/CHMP2A/VPS4A/HMGB1/IFNGR2/FTH1/SLC25A4/PLA2G4D/TICAM1/PGAM5/IL1B/GLUD1/CHMP4B/BAX/VDAC2/STAT6/TYK2/MLKL/STAT5B/CFLAR/PPIA/SLC25A5/USP21/JAK3/CHMP6/SPATA2L/VPS4B/STAT5A/RIPK3/FADD/TNFRSF1A/IFNAR1/RIPK1/CYLD/PYCARD/FTL/TNFAIP3/BID/SQSTM1/PLA2G4C/SMPD1/PYGM/RBCK1/CHMP1B/JMJD7-PLA2G4B/PLA2G4B/CHMP2B/JAK1/FAS/PYGL/GLUD2/XIAP/AIFM1/CHMP1A/TNF/MAPK9/HSP90AB1/PARP1/TRADD/TRAF2/IFNA8/GLUL/CASP8/PLA2G4F/CYBB/NLRP3/JAK2/CAMK2A/STAT4/VDAC3/IFNA10/IFNA14/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/RNF31/IFNA16/DNM1L/IRF9/BIRC2/SLC25A6/CAMK2B/TNFRSF10B/IFNG/PYGB/PPID/IFNGR1/CAPN2/FASLG/CASP1/CAMK2D/MAPK8/FAF1/HSP90AA1/PLA2G4A/SHARPIN/TNFSF10/CHMP7/IFNA17/STAT3/ALOX15/TLR4/ZBP1/MAPK10/TRPM7/STAT2/CHMP4C/TRAF5/BCL2/TNFRSF10A/STAT1/VDAC1/TICAM2/BIRC3/EIF2AK2/IFNAR2/CAPN1/IL1A	128
KEGG	hsa00730	Thiamine metabolism	11/6806	15/8135	0.9165	0.9718	0.3553	ALPP/NFS1/AK2/ACP1/AK1/ALPL/AK5/ALPI/AK7/THTPA/TPK1	11
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	53/6806	69/8135	0.951	1	0.3656	UGT2B4/UGT2A3/CYP2A7/UGT2B17/NAT2/CYP2C19/SULT1A3/SULT1A4/SULT1A2/GSTA3/PTGS2/GSTO1/GSTK1/NAT1/EPHX1/AKR1C2/GSTT1/HSD11B1/GSTP1/CYP1A1/SULT1A1/MGST3/CYP1B1/CYP2C18/MGST1/UGT1A10/UGT1A7/UGT1A8/SULT2A1/CYP2C9/CYP2C8/GSTO2/CBR1/CYP2A6/GSTT2/GSTM4/GSTM3/CYP3A4/CYP3A7/UGT2B15/CYP2A13/GSTM1/MGST2/CYP2E1/GSTA4/UGT2A1/UGT2A2/GSTM5/GSTM2/CYP3A43/CYP3A5/UGT2B28/CYP1A2	53
KEGG	hsa00310	Lysine degradation	48/6806	63/8135	0.9571	1	0.3656	PLOD3/HADHA/AASS/NSD1/DLD/EZH1/HADH/EHMT2/PRDM2/SUV39H1/ALDH9A1/ECHS1/SETD7/ALDH2/SMYD1/SETDB1/SETD2/GCDH/ASH1L/TMLHE/EHMT1/SETD1A/DLST/PLOD1/ALDH1B1/SMYD2/ALDH3A2/DHTKD1/SMYD3/SETDB2/PRDM16/ALDH7A1/ACAT2/ACAT1/SETMAR/SETD1B/AADAT/PLOD2/PRDM7/DOT1L/PRDM9/EZH2/PRDM6/PIPOX/SUV39H2/MECOM/BBOX1/EHHADH	48
KEGG	hsa00860	Porphyrin metabolism	32/6806	43/8135	0.9615	1	0.3656	UGT2B4/UGT2A3/UGT2B17/FXN/GUSB/HMOX2/PPOX/UROD/ALAS1/UROS/ALAD/CP/COX15/HMOX1/UGT1A10/UGT1A7/UGT1A8/EARS2/BLVRA/HMBS/BLVRB/HEPH/COX10/CPOX/UGT2B15/HCCS/MMAB/UGT2A1/UGT2A2/ALAS2/UGT2B28/FECH	32
KEGG	hsa00514	Other types of O-glycan biosynthesis	35/6806	47/8135	0.9657	1	0.3656	PLOD3/B4GALT1/GALNTL6/GALNT7/POMT1/GALNT10/POMT2/B4GALT2/C1GALT1C1/GALNT9/B4GALT3/GALNT1/GALNT2/GXYLT1/MFNG/RFNG/POFUT2/GALNT4/GALNTL5/POFUT1/GALNT3/GALNT12/OGT/GALNT6/ST6GAL2/ST3GAL3/LFNG/GXYLT2/C1GALT1/GALNT11/GALNT14/GALNT13/GALNT8/ST6GAL1/GALNT5	35
KEGG	hsa00515	Mannose type O-glycan biosynthesis	16/6806	23/8135	0.9755	1	0.3656	B4GALT1/POMT1/POMT2/B4GALT2/POMGNT1/B4GALT3/B3GALNT2/CHST10/FKRP/MGAT5B/FUT9/B3GAT1/ST3GAL3/FKTN/FUT4/B3GAT2	16
KEGG	hsa00982	Drug metabolism - cytochrome P450	54/6806	72/8135	0.9802	1	0.3656	UGT2B4/UGT2A3/CYP2A7/ADH1B/UGT2B17/ADH7/FMO3/AOX1/CYP2C19/ADH5/ADH1A/GSTA3/GSTO1/GSTK1/CYP2D6/GSTT1/GSTP1/MGST3/MGST1/UGT1A10/UGT1A7/UGT1A8/CYP2C9/MAOA/CYP2C8/ALDH3B1/GSTO2/CYP2A6/GSTT2/GSTM4/FMO2/GSTM3/CYP3A4/ALDH3B2/FMO1/UGT2B15/GSTM1/ADH4/ALDH3A1/CYP2B6/MGST2/CYP2E1/GSTA4/UGT2A1/UGT2A2/GSTM5/GSTM2/CYP3A5/ADH1C/MAOB/UGT2B28/CYP1A2/FMO5/ADH6	54
KEGG	hsa05203	Viral carcinogenesis	160/6806	204/8135	0.9812	1	0.3656	HLA-E/ATP6V0D1/CREB3/BAD/ATF4/UBR4/GRB2/CCND1/GTF2H1/RAC1/USP7/SRF/HDAC2/RHOA/GTF2A2/LTBR/BAX/CASP3/MDM2/GTF2B/PSMC1/MAPK1/HDAC1/PIK3CB/STAT5B/POLB/GTF2E2/BAK1/SYK/ACTN1/JAK3/IKBKG/HDAC7/ATF6B/PIK3CD/PRKACA/HRAS/STAT5A/TRAF3/HDAC3/HDAC11/HDAC8/KAT2B/NFKBIA/EP300/HLA-C/VAC14/IRF3/HDAC5/GTF2H2/GTF2H2C/MAPK3/PXN/PIK3CA/NFKB1/HLA-B/C3/JAK1/TBPL1/HLA-A/CDK2/PIK3R2/NFKB2/CDC42/GSN/MAPKAPK2/ACTN4/UBE3A/MAD1L1/RANBP1/TRADD/CDK1/TRAF2/YWHAQ/RASA2/CCND3/YWHAE/PIK3R1/SKP2/IL6ST/HNRNPK/HDAC6/CASP8/DDX3X/YWHAZ/CDKN1B/DDB1/ATP6V0D2/LYN/SCIN/CHD4/YWHAH/SNW1/YWHAG/JUN/NRAS/YWHAB/CDKN2A/VDAC3/CCND2/HLA-G/CDK4/GTF2E1/HLA-F/RBPJ/GTF2A1L/IRF9/HDAC9/CREB3L4/SP100/TBP/CDKN2B/MRPS18B/KRAS/CREB3L2/PRKACB/RB1/PRKACG/GTF2H3/CREB5/TRAF1/CDK6/TP53/CREB3L1/DNAJA3/CCNA2/RBL2/CDKN1A/RELA/HDAC10/DLG1/ATF2/CREB1/STAT3/SND1/SCRIB/CCR3/SRC/CCNE1/CCNE2/HPN/RBPJL/PIK3R3/HDAC4/TRAF5/IRF7/CCR4/PMAIP1/CREBBP/GTF2A1/KAT2A/EIF2AK2/REL/RBL1/CREB3L3/EGR2/CCNA1/GTF2H4/CCR5/CHEK1	160
KEGG	hsa00053	Ascorbate and aldarate metabolism	21/6806	30/8135	0.9829	1	0.3656	UGT2B4/UGT2A3/UGT2B17/AKR1A1/GUSB/ALDH9A1/ALDH2/ALDH1B1/ALDH3A2/ALDH7A1/UGT1A10/UGT1A7/UGT1A8/MIOX/RGN/UGT2B15/KL/UGT2A1/UGT2A2/UGT2B28/UGDH	21
KEGG	hsa00190	Oxidative phosphorylation	103/6806	134/8135	0.9853	1	0.3656	COX6A2/COX4I2/COX8C/NDUFS7/NDUFS1/UQCRQ/ATP6V1H/UQCRB/NDUFC1/NDUFA1/ATP6V0D1/NDUFS2/NDUFV2/NDUFB10/COX5B/SDHB/NDUFB3/COX17/NDUFB11/UQCRH/NDUFB4/NDUFA2/ATP6V1E2/NDUFA7/NDUFA10/COX7B/UQCR10/COX8A/ATP6V0A1/ATP6AP1/NDUFB8/NDUFS8/NDUFA13/COX6B1/ATP6V1F/UQCRFS1/UQCRC2/NDUFB2/ATP6V1E1/NDUFS4/NDUFB6/NDUFA12/COX6B2/ATP4B/SDHA/COX4I1/NDUFA4/CYC1/ATP6V1G1/TCIRG1/LHPP/NDUFA3/NDUFV1/NDUFA8/ATP6V0B/NDUFS3/ATP6V1B2/NDUFC2/PPA1/NDUFA11/COX6C/UQCR11/NDUFA9/NDUFA6/ATP6V1B1/ATP6V0A2/SDHC/COX7A2/ATP6V1A/ATP6V0E2/NDUFAB1/ATP6V0D2/NDUFB7/ATP6V1D/ATP6V0C/ATP6V1C1/NDUFB9/COX11/NDUFV3/NDUFS5/ATP6V0E1/ATP6V1G3/COX5A/NDUFS6/COX7B2/COX6A1/PPA2/COX15/NDUFA5/COX7C/SDHD/NDUFB1/CYCS/NDUFB5/COX10/UQCRC1/ATP6V1G2/NDUFA4L2/COX7A2L/ATP6V0A4/ATP12A/ATP4A/ATP6V1C2	103
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	58/6806	78/8135	0.9882	1	0.3656	UGT2B4/UGT2A3/CYP2A7/ADH1B/UGT2B17/ADH7/CYP2S1/ADH5/ADH1A/GSTA3/GSTO1/GSTK1/CYP2D6/EPHX1/GSTT1/HSD11B1/GSTP1/CYP1A1/CYP2F1/MGST3/CYP1B1/MGST1/UGT1A10/UGT1A7/UGT1A8/SULT2A1/AKR7A2/CYP2C9/ALDH3B1/AKR7A3/GSTO2/CBR3/CBR1/CYP2A6/GSTT2/GSTM4/GSTM3/CYP3A4/ALDH3B2/UGT2B15/CYP2A13/GSTM1/DHDH/ADH4/ALDH3A1/CYP2B6/MGST2/CYP2E1/GSTA4/UGT2A1/UGT2A2/GSTM5/GSTM2/CYP3A5/ADH1C/UGT2B28/CYP1A2/ADH6	58
KEGG	hsa03040	Spliceosome	113/6806	147/8135	0.9884	1	0.3656	SF3B2/DDX46/U2AF2/LSM2/SF3B5/CCDC12/PCBP1/SNRPC/CWC15/DHX8/TXNL4A/SNRNP200/PRPF8/ACIN1/LSM4/LSM3/CTNNBL1/U2AF1/USP39/SNRPB2/RBM22/NCBP1/PUF60/XAB2/BUD31/DDX23/BCAS2/HNRNPM/PRPF3/AQR/SNRPA1/TRA2B/DHX15/PRPF40A/SF3B4/SNRPD3/CDC40/SNRNP70/SART1/SF3B3/PRPF38A/SF3A3/EIF4A3/ZMAT2/DHX16/SNRPB/DDX42/THOC2/HSPA1L/EFTUD2/PRPF6/LSM7/HSPA6/SNRPD2/PRPF4/RBM17/PLRG1/WBP11/PPIL1/U2AF1L4/DHX38/HNRNPU/SMNDC1/LSM6/THOC1/SNRPA/SYF2/SNRPF/HSPA8/PQBP1/HSPA1B/SNRPG/MAGOH/HNRNPA3/CRNKL1/SLU7/HNRNPK/HNRNPC/PRPF19/SF3B1/SNW1/SNRPE/MAGOHB/PRPF40B/CHERP/HSPA1A/RBM25/LSM5/PRPF18/PPIE/HNRNPA1/HNRNPA1L2/PPIH/THOC3/DDX5/RBM8A/PRPF31/SF3A2/RP9/FUS/SF3A1/TCERG1/SNRNP40/NCBP2/SNRNP27/PHF5A/CDC5L/TRA2A/SNRPD1/RBMX/HSPA2/ISY1/PRPF38B	113
KEGG	hsa00040	Pentose and glucuronate interconversions	23/6806	34/8135	0.9944	1	0.3656	UGT2B4/UGT2A3/UGT2B17/AKR1A1/GUSB/SORD/UGP2/DCXR/CRYL1/AKR1B1/XYLB/UGT1A10/UGT1A7/UGT1A8/RPE/UGT2B15/AKR1B10/DHDH/KL/UGT2A1/UGT2A2/UGT2B28/UGDH	23
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	68/6806	109/8135	1	1	0.3656	RAN/NXF1/CSNK2B/NVL/POP7/MPHOSPH10/HEATR1/RPP30/GNL2/RPP38/RPP25/WDR75/POP4/CSNK2A2/UTP6/NOP10/IMP3/CSNK2A1/GNL3/PWP2/POP5/XRN2/NOP56/NOB1/NXT2/EIF6/IMP4/FBL/RRP7A/WDR36/SBDS/RIOK1/GAR1/RPP40/LSG1/GNL3L/WDR43/NHP2/NXF2/NXF2B/UTP18/BMS1/TBL3/NOL6/TCOF1/DKC1/UTP14A/NXT1/NAT10/REXO1/NOP58/XPO1/FCF1/UTP15/RBM28/MDN1/EMG1/NMD3/GTPBP4/WDR3/REXO2/FBLL1/POP1/UTP14C/XRN1/RCL1/SPATA5/RIOK2	68
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	24/6806	66/8135	1	1	0.3656	PARS2/HARS2/CARS2/YARS2/FARSB/GATC/IARS2/FARS2/MTFMT/RARS2/TARS2/SEPSECS/NARS2/EARS2/FARSA/SARS2/VARS2/PSTK/LARS2/AARS2/WARS2/MARS2/QRSL1/DARS2	24
KEGG	hsa04613	Neutrophil extracellular trap formation	107/6806	190/8135	1	1	0.3656	SLC25A31/HAT1/ITGB2/RAC1/ACTG1/MAP2K2/VWF/HMGB1/HDAC2/PLCB2/SLC25A4/MAPK14/NCF4/VDAC2/PRKCB/FGB/MAPK1/HDAC1/PIK3CB/SLC25A5/NCF1/SYK/GSDMD/HDAC7/ITGAL/PIK3CD/AKT3/FCGR2A/SELPLG/RAF1/NCF2/HDAC3/HDAC11/TLR8/HDAC8/RAC2/MAP3K7/MTOR/HDAC5/PLCG2/ITGAM/MAPK3/PIK3CA/CASP4/NFKB1/MAPK12/ACTB/C3/CLCN5/CLCN3/ITGA2B/PIK3R2/C5AR1/MAPK13/AZU1/PPIF/CYBA/FPR1/AKT2/AGER/PIK3R1/HDAC6/GP1BA/CYBB/CAMP/PLCB4/AKT1/SELP/VDAC3/MAPK11/ATG7/HDAC9/SIGLEC9/SLC25A6/CLEC7A/PADI4/TLR2/TLR7/PLCB3/CASP1/FCGR1A/AQP9/FCGR3B/FCGR3A/CR1L/PLCB1/PRKCG/RELA/ITGB3/HDAC10/C5/PRKCA/PLCG1/TLR4/SRC/MPO/FPR2/CLCN4/PIK3R3/CR1/HDAC4/VDAC1/FGA/FPR3/MAP2K1/CTSG/FGG	107
KEGG	hsa04740	Olfactory transduction	126/6806	440/8135	1	1	0.3656	OR10A5/OR14J1/OR2J3/OR6B1/GNG13/CNGA3/OR12D2/OR5I1/OR2B2/OR52A1/OR51B4/OR51I2/OR2A7/OR51E1/OR1A2/OR1A1/OR1D2/OR6A2/OR12D3/OR1G1/OR2W1/PDE1A/OR4D2/OR11A1/OR8D2/OR2C3/CAMK2G/OR2B3/ARRB1/GNB1/PRKG2/CALML6/OR5L2/OR5V1/ARRB2/OR13C4/OR5P2/GUCY2D/OR7A5/OR51B6/OR51B5/PRKACA/OR1J2/OR7E24/CALM1/OR1Q1/OR10H3/CALML4/OR2H2/OR1J4/GNG7/OR5J2/RGS2/CALML5/PDE1B/NCALD/OR2L13/OR3A2/OR3A1/SLC8A1/OR5H14/OR5H15/OR7A17/OR51B2/CAMK2A/OR1E1/OR1E2/CALML3/OR2J2/OR10C1/OR1C1/OR10J1/CNGA4/CNGB1/SLC8A3/CAMK2B/OR8G1/OR2H1/PRKACB/PRKACG/OR2C1/OR8B8/OR2S2/CAMK2D/OR52D1/OR10A4/OR4F16/OR4F21/OR4F29/OR4F3/OR7A10/PDE2A/OR8D1/CALM2/OR2F1/OR7C2/OR1F1/CALM3/OR2M4/OR51M1/OR51E2/OR10H2/OR51I1/OR2W3/OR2A4/OR5P3/OR5H1/SLC24A4/OR2F2/PRKG1/OR4D1/OR7C1/OR2L2/OR2B6/OR51J1/ADCY3/OR2K2/PDE1C/OR2A5/OR5K1/ANO2/OR10H1/GNAL/OR3A3/OR10A3/SLC8A2	126
KEGG	hsa05034	Alcoholism	104/6806	187/8135	1	1	0.3656	GNG13/ADORA2A/HAT1/CREB3/ATF4/GRB2/GNB1/GNG2/CALML6/HDAC2/GNG5/GNB2/GNAI1/SLC29A3/ADORA2B/MAPK1/HDAC1/ARAF/HDAC7/CRH/ATF6B/PRKACA/SHC1/HRAS/PPP1CA/RAF1/HDAC3/CALM1/HDAC11/HDAC8/SHC3/GNGT2/HDAC5/CAMKK1/MAPK3/PPP1CB/SLC29A2/CALML4/GNG3/GNG8/GNG7/GNG10/PPP1CC/HDAC6/GNAI2/CALML5/SOS1/GNAI3/GNAS/GNB3/SOS2/NRAS/GNAO1/GNG11/GRIN2D/CALML3/GNG12/GNB5/HDAC9/CREB3L4/DRD1/MAOA/BDNF/KRAS/CREB3L2/PRKACB/PRKACG/GRIN2C/GRIN2B/CREB5/BRAF/CREB3L1/TH/SLC29A1/CALM2/GNGT1/CAMKK2/HDAC10/GRIN3B/ATF2/CREB1/GRIN2A/CALM3/NTRK2/GRIN3A/SHC4/GRIN1/SLC18A2/HDAC4/GNB4/SLC18A1/DRD2/FOSB/GNG4/PPP1R1B/ADCY5/CAMK4/MAP2K1/MAOB/PKIA/SLC6A3/NPY/CREB3L3/SHC2	104
KEGG	hsa05206	MicroRNAs in cancer	161/6806	310/8135	1	1	0.3656	CYP24A1/TNN/ZFPM2/EFNA3/SERPINB5/WNT3/UBE2I/BCL2L11/GRB2/CCND1/ITGA5/RPTOR/MAP2K2/TGFB2/HDAC2/CRKL/RHOA/CASP3/EFNA4/PRKCB/MDM2/BMF/MAPK1/HDAC1/PIK3CB/NOTCH1/BAK1/APC2/MAPK7/ABCC1/PDGFRB/CCNG1/PIK3CD/SHC1/PTGS2/HRAS/DNMT1/RAF1/EZR/DNMT3A/E2F1/EP300/RASSF1/ROCK1/MTOR/HDAC5/PLCG2/STMN1/MAPK3/PIK3CA/DNMT3B/NFKB1/PTEN/ST14/FSCN1/PIK3R2/IKBKB/GLS/IRS2/BCL2L2/VIM/ATM/TP63/PIK3R1/HNRNPK/MIR21/CDKN1B/BRCA1/MIR101-1/SOS1/CYP1B1/MIRLET7D/CDC25B/ABCB1/RDX/SIRT1/TNXB/SOS2/NRAS/CDCA5/MYC/THBS1/ABL1/PDGFB/IGF2BP1/CDKN2A/CRK/CCND2/MMP16/SOX4/SLC7A1/HMOX1/PLAU/VEGFA/IRS1/CD44/DICER1/ERBB2/MMP9/KRAS/MCL1/PAK4/BMI1/CDK6/MARCKS/TP53/E2F3/MDM4/PRKCG/CDKN1A/ITGB3/EFNA5/ZEB1/DDIT4/MIR30C2/PRKCA/PLCG1/CDC25C/STAT3/EFNA1/TIMP3/NOTCH2/EZH2/SLC45A3/SHC4/MIR214/CCNE1/CCNE2/ZEB2/EFNA2/PIK3R3/PIM1/HDAC4/PDGFA/PDCD4/BCL2/MIR10B/HOXD10/RPS6KA5/PRKCE/TPM1/SOCS1/GLS2/HMGA2/APC/BMPR2/CREBBP/RECK/MAP2K1/NOTCH3/ERBB3/KIF23/NOTCH4/TNC/PDGFRA/TNR/FGFR3/EGFR/MET/FZD3/CDC25A	161
KEGG	hsa05322	Systemic lupus erythematosus	52/6806	136/8135	1	1	0.3656	CD40/C1R/C9/C6/ACTN1/FCGR2A/SNRPD3/HLA-DRA/SNRPB/C2/C3/TNF/ACTN4/SSB/C1QB/HLA-DMA/C1QA/TRIM21/HLA-DRB1/HLA-DRB4/HLA-DQB1/HLA-DMB/IL10/IFNG/CD86/HLA-DRB3/HLA-DRB5/GRIN2B/FCGR1A/HLA-DOA/FCGR3B/FCGR3A/C5/C1S/GRIN2A/HLA-DPA1/C8A/CD40LG/CD28/HLA-DPB1/CD80/SNRPD1/HLA-DOB/HLA-DQA1/HLA-DQA2/C4A/C4B/C8B/C1QC/CTSG/C8G/C7	52