ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04142	Lysosome	56/1588	132/8135	1.074e-09	3.587e-07	2.996e-07	CLTCL1/CTSB/ACP5/LGMN/CTNS/ARSG/SLC11A2/GBA/NPC1/CTSS/DNASE2/NPC2/GNPTG/IDS/GUSB/IDUA/GLA/AP3S1/LITAF/NAGPA/PLA2G15/ACP2/CTSH/DNASE2B/ATP6V0A1/LAPTM4B/DMXL2/HEXB/AP3D1/AP1G2/HYAL4/LAPTM5/AP1B1/AP3M2/HYAL3/CTSA/CD63/SCARB2/ABCB9/AP4M1/AP4B1/MCOLN1/LAMP3/CTSD/ENTPD4/ATP6V0D1/AP3S2/CTSO/CD68/ATP6AP1/ARSB/M6PR/PPT2/GGA3/AP3B1/NEU1	56
KEGG	hsa05169	Epstein-Barr virus infection	67/1588	202/8135	2.449e-06	0.0004089	0.0003415	CDK6/MAPK13/HLA-DPA1/RBPJ/STAT3/MAP2K7/PIK3CD/APAF1/PSMD14/HLA-DOA/HLA-DMA/SAP30L/ITGAL/PSMC2/CALR/RB1/RBPJL/MAP2K6/CD40/HLA-DRA/MAP2K3/PSMD12/CDK2/CDKN1A/SKP2/HLA-DQA1/MAPK14/TRAF2/HLA-DPB1/IRF3/TNFAIP3/PSMC1/IFNAR1/PSMD3/PSMC3/CCND1/BID/CASP8/TAPBP/CDKN1B/CD3D/E2F2/MYD88/TRAF3/NFKBIE/PSMD7/HLA-DQB1/CCND2/IKBKE/SNW1/MAP3K14/PSMD1/CDK4/PSMD2/GADD45A/CD3G/CCNA2/CD58/PSMD8/CD247/PIK3R2/BCL2/PSMD4/BTK/MYC/CD44/MAPK11	67
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	68/1588	222/8135	4.111e-05	0.004576	0.003822	NRP1/VDAC1/NRAS/ADCY3/HLA-DPA1/PIK3CD/IL2RG/BCL2L1/HLA-DOA/HLA-DMA/ITGAL/PTEN/ADCY9/CALR/RB1/PTTG2/SLC2A1/CD40/CREBBP/KAT2A/CANX/KRAS/HLA-DRA/SMAD3/CDK2/CDKN1A/HLA-DQA1/HLA-DPB1/NFYB/TBP/VAC14/STAT5A/PPP3CC/PTTG1/RAN/CCND1/CD3D/E2F2/CCNB2/TGFBR1/HLA-DQB1/IL2RB/CCND2/IL1R2/STAT5B/FOS/MAP3K14/MAP3K3/CDK4/CREB3/TLN2/TCF3/XPO1/CD3G/SLC25A4/CCNA2/IL15/CDKN2B/SMAD2/CDC20/PPP3CB/NFATC3/PIK3R2/HRAS/ETS1/MYC/CDKN2A/LCK	68
KEGG	hsa04145	Phagosome	50/1588	152/8135	5.793e-05	0.004837	0.00404	OLR1/COLEC12/ITGB5/FCGR2B/MSR1/HLA-DPA1/ITGAV/TUBA1B/CORO1A/SFTPD/TUBA1C/HLA-DOA/HLA-DMA/RAB7B/CTSS/TUBB6/ATP6V1E2/TUBB/RAB5A/CALR/TUBA4A/TFRC/TUBA1A/CANX/ACTG1/ATP6V0A1/FCGR1A/HLA-DRA/TUBB3/TUBB2A/HLA-DQA1/HLA-DPB1/NCF1/MARCO/ACTB/NCF4/C1R/CLEC7A/HLA-DQB1/VAMP3/MPO/ATP6V0D1/FCAR/ATP6AP1/DYNC2H1/M6PR/DYNC1I2/EEA1/THBS1/ITGA5	50
KEGG	hsa04141	Protein processing in endoplasmic reticulum	53/1588	171/8135	0.0002027	0.01354	0.01131	HSPA1L/MAP2K7/HSPA5/EIF2AK4/HSP90B1/PDIA6/CALR/ERP29/DNAJC3/RRBP1/DNAJB11/UBXN1/SYVN1/SEC31B/PRKCSH/CANX/NPLOC4/MAN1C1/TRAF2/UBE4B/MAN1A2/DNAJC5/EDEM2/NFE2L2/DNAJB1/SEC62/PDIA4/UBE2J1/DERL2/HYOU1/DNAJC10/SSR2/VCP/SIL1/MBTPS1/UBXN2A/MBTPS2/EDEM3/DERL1/BCAP31/RNF185/RPN1/TRAM1/BAG1/ERN1/ATF6/SSR1/BCL2/SEL1L/HSPH1/UBQLN1/SEC24A/UBXN6	53
KEGG	hsa04218	Cellular senescence	48/1588	156/8135	0.0004776	0.02433	0.02032	VDAC1/CDK6/NRAS/MRAS/MAPK13/PIK3CD/RBL1/PTEN/RHEB/RB1/ZFP36L2/MAP2K6/KRAS/MAP2K3/SMAD3/RRAS2/CDK2/CDKN1A/MAPK14/PPP3CC/CALM1/CCND1/LIN52/E2F2/CCNB2/ITPR2/TGFBR1/SIRT1/CCND2/TSC2/CDK4/GADD45A/SLC25A4/CCNA2/SERPINE1/CDKN2B/SMAD2/EIF4EBP1/PPP3CB/BTRC/NFATC3/CACNA1D/PIK3R2/HRAS/ETS1/MYC/CDKN2A/MAPK11	48
KEGG	hsa05221	Acute myeloid leukemia	25/1588	67/8135	0.00051	0.02433	0.02032	TCF7L2/PIM1/ZBTB16/NRAS/STAT3/PIK3CD/DUSP6/KRAS/FCGR1A/CSF1R/SOS2/PPARD/STAT5A/GRB2/CCND1/CEBPE/PIM2/MPO/RARA/STAT5B/CCNA2/EIF4EBP1/PIK3R2/HRAS/MYC	25
KEGG	hsa04068	FoxO signaling pathway	41/1588	131/8135	0.0008241	0.0334	0.02789	NRAS/MAPK13/CDKN2D/STAT3/PIK3CD/IL7R/PTEN/PLK1/CAT/PRKAG2/CREBBP/PLK4/KRAS/SMAD3/CDK2/SOS2/CDKN1A/SKP2/MAPK14/GABARAPL1/BNIP3/GRB2/CCND1/CDKN1B/FOXO4/CCNB2/TGFBR1/SIRT1/TNFSF10/CCND2/CSNK1E/GABARAP/IRS2/STK11/PRKAB2/GADD45A/CDKN2B/S1PR4/PIK3R2/HRAS/MAPK11	41
KEGG	hsa04658	Th1 and Th2 cell differentiation	31/1588	92/8135	9e-04	0.0334	0.02789	MAPK13/MAF/HLA-DPA1/RBPJ/IL2RG/PRKCQ/HLA-DOA/HLA-DMA/RBPJL/HLA-DRA/NOTCH2/HLA-DQA1/MAPK14/HLA-DPB1/STAT5A/PPP3CC/STAT4/CD3D/NFKBIE/HLA-DQB1/IL2RB/STAT5B/FOS/CD3G/DLL1/STAT6/PPP3CB/CD247/NFATC3/MAPK11/LCK	31
KEGG	hsa01230	Biosynthesis of amino acids	26/1588	75/8135	0.001425	0.0414	0.03457	GLUL/SDS/SDSL/ENO1/ALDH18A1/PGK1/TKT/TALDO1/BCAT1/TPI1/IDH2/GOT1/ALDOC/PFKP/CBS/RPIA/PFKM/PRPS1/PRPS2/ENO2/MAT2A/IDH3A/MAT2B/ENO3/IDH3B/SHMT2	26
KEGG	hsa05418	Fluid shear stress and atherosclerosis	42/1588	139/8135	0.001558	0.0414	0.03457	MGST1/MAPK13/PDGFB/MAP2K7/ITGAV/PIK3CD/SUMO3/SDC4/HSP90B1/GSTO1/MAP2K6/GSTM1/ACTG1/RAC2/GSTM4/ARHGEF2/CCL2/MAPK14/NQO1/NFE2L2/NCF1/MEF2A/GSTM2/ACTB/SUMO2/DUSP1/CALM1/CTNNB1/MAP2K5/SDC2/IL1R2/GSTP1/GSTM5/PTK2/FOS/PECAM1/MMP9/PIK3R2/BCL2/MMP2/THBD/MAPK11	42
KEGG	hsa01200	Carbon metabolism	36/1588	115/8135	0.001659	0.0414	0.03457	SDS/SDSL/ENO1/PGK1/TKT/TALDO1/TPI1/ACSS1/IDH2/GOT1/FBP1/ALDOC/PFKP/CAT/PGD/RPIA/PFKM/PRPS1/GPI/PRPS2/ESD/ENO2/SDHD/PCCA/ACAT1/AMT/MCEE/PDHB/IDH3A/PGLS/HK3/ME3/ENO3/IDH3B/SHMT2/ME1	36
KEGG	hsa05163	Human cytomegalovirus infection	62/1588	225/8135	0.001931	0.0414	0.03457	GNG10/CDK6/NRAS/ADCY3/MAPK13/GNA12/STAT3/ITGAV/PIK3CD/PLCB1/PLCB2/ARHGEF1/ADCY9/RHEB/CALR/RB1/SP1/MAP2K6/PTK2B/KRAS/RAC2/CCL2/GNAS/SOS2/CDKN1A/MAPK14/TRAF2/IRF3/GRB2/PPP3CC/CCL5/CALM1/CCND1/BID/CASP8/TAPBP/GNG2/CTNNB1/E2F2/ITPR2/CCL4L1/PRKCA/PTGS2/TSC2/PTK2/PTGER2/CDK4/CREB3/PXN/EIF4EBP1/PPP3CB/NFATC3/GNG11/IL10RA/GNB1/PIK3R2/HRAS/CCR3/MYC/CDKN2A/MAPK11/CXCR4	62
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/1588	100/8135	0.001978	0.0414	0.03457	PIM1/NRAS/MAPK13/FN1/STAT3/PIK3CD/PLCB1/PLCB2/VEGFB/PLCD1/KRAS/SMAD3/CCL2/MAPK14/STAT5A/PRKCD/CCND1/AGER/CDKN1B/TGFBR1/PRKCA/STAT5B/CDK4/COL4A5/SERPINE1/SMAD2/PIK3R2/BCL2/MMP2/THBD/HRAS/MAPK11	32
KEGG	hsa04659	Th17 cell differentiation	34/1588	108/8135	0.001982	0.0414	0.03457	MAPK13/HLA-DPA1/STAT3/IL2RG/PRKCQ/HLA-DOA/HLA-DMA/HLA-DRA/SMAD3/HLA-DQA1/MAPK14/HLA-DPB1/STAT5A/PPP3CC/RXRA/CD3D/EBI3/TGFBR1/NFKBIE/HLA-DQB1/IL2RB/IRF4/RARA/STAT5B/FOS/CD3G/SMAD2/FOXP3/STAT6/PPP3CB/CD247/NFATC3/MAPK11/LCK	34
KEGG	hsa04660	T cell receptor signaling pathway	33/1588	104/8135	0.001983	0.0414	0.03457	NRAS/MAPK13/MAP2K7/PIK3CD/MAP3K8/PRKCQ/KRAS/SOS2/MAPK14/GRB2/PPP3CC/NCK1/CBLB/CD3D/PTPN6/NFKBIE/PAK1/FOS/MAP3K14/CDK4/PAK2/CD8A/CD3G/ITK/PPP3CB/CD247/NFATC3/TEC/PIK3R2/ICOS/HRAS/MAPK11/LCK	33
KEGG	hsa05171	Coronavirus disease - COVID-19	63/1588	232/8135	0.002612	0.04958	0.04141	NRP1/MAPK13/C1QC/STAT3/PIK3CD/C3AR1/C1QB/RPL13A/RPL22/CASP1/RPS3A/RPL17/RPL5/RPL13/RPL28/C8G/RPL32/CCL2/RPL4/MAPK14/IRF3/RPL7/RPL7A/CFB/IFNAR1/CFD/RPLP1/RPL23A/C1R/C1QA/C5/MYD88/TRAF3/RPL11/RPL23/PRKCA/RPL9/RPS15A/RPS9/IKBKE/RPS4X/RPL37A/RPS2/FOS/F13B/RPS6/RPL12/RPS14/RPS3/RPS4Y2/RPS13/RPL35A/RPS23/RPL30/RPL21/RPLP2/RPL27A/RPL19/PIK3R2/RPL31/RPS17/MAPK11/RPS20	63
KEGG	hsa04662	B cell receptor signaling pathway	27/1588	82/8135	0.002738	0.04958	0.04141	CD81/NRAS/LILRB4/FCGR2B/PIK3CD/RASGRP3/CD72/LILRB5/KRAS/RAC2/CD79B/LILRA1/SOS2/LILRA3/INPP5D/INPPL1/GRB2/PPP3CC/DAPP1/PTPN6/NFKBIE/FOS/PPP3CB/NFATC3/PIK3R2/HRAS/BTK	27
KEGG	hsa01522	Endocrine resistance	31/1588	98/8135	0.00282	0.04958	0.04141	NRAS/ADCY3/MAPK13/PIK3CD/CARM1/ADCY9/RB1/SP1/KRAS/GNAS/NOTCH2/SOS2/CDKN1A/MAPK14/GRB2/CCND1/CDKN1B/E2F2/NOTCH4/PTK2/FOS/CDK4/MMP9/DLL1/PIK3R2/BCL2/MMP2/HRAS/ESR1/CDKN2A/MAPK11	31
KEGG	hsa04640	Hematopoietic cell lineage	31/1588	99/8135	0.003356	0.05604	0.0468	CD9/CD1D/HLA-DPA1/CD33/HLA-DOA/HLA-DMA/IL11RA/IL7R/CD2/TFRC/FCGR1A/HLA-DRA/CSF1R/HLA-DQA1/HLA-DPB1/GP9/CSF3R/CD37/CD3D/ITGA3/HLA-DQB1/IL1R2/CD59/CD8A/CD3G/CD1E/CD5/CD38/EPOR/CD44/ITGA5	31
KEGG	hsa04919	Thyroid hormone signaling pathway	36/1588	121/8135	0.004316	0.06864	0.05733	NRAS/NCOA1/ITGAV/PIK3CD/PLCB1/PLCB2/PFKP/RHEB/ATP1B3/PLCD1/SLC2A1/CREBBP/KAT2A/ATP2A2/ACTG1/KRAS/PFKM/SLC16A10/NOTCH2/ACTB/RXRA/CCND1/CTNNB1/NOTCH4/SLC16A2/PRKCA/MED16/TSC2/ATP1A3/ATP1A1/ATP1B2/PIK3R2/HRAS/ESR1/MYC/ATP1B1	36
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	28/1588	89/8135	0.004794	0.07278	0.06078	NRAS/MAPK13/STAT3/PIK3CD/PRKCQ/PTEN/EML4/MAP2K6/KRAS/MAP2K3/MAPK14/PPP3CC/CD3D/PTPN6/MYD88/NFKBIE/CSNK2A2/FOS/MAP3K3/CD3G/CD274/PPP3CB/CD247/NFATC3/PIK3R2/HRAS/MAPK11/LCK	28
KEGG	hsa00270	Cysteine and methionine metabolism	18/1588	51/8135	0.005947	0.08636	0.07212	IL4I1/LDHA/SDS/SDSL/BCAT1/MPST/GOT1/CBS/GSS/DNMT1/ENOPH1/AHCYL2/LDHB/DNMT3A/TST/MAT2A/MAT2B/MTAP	18
KEGG	hsa05161	Hepatitis B	45/1588	162/8135	0.006446	0.0897	0.07492	NRAS/MAPK13/STAT3/MAP2K7/PIK3CD/APAF1/RB1/MAP2K6/PTK2B/CREBBP/KRAS/YWHAQ/MAP2K3/SMAD3/CDK2/SOS2/CDKN1A/MAPK14/IRF3/STAT5A/GRB2/IFNAR1/STAT4/BID/CASP8/CASP10/E2F2/MYD88/TRAF3/TGFBR1/PRKCA/IKBKE/STAT5B/FOS/CREB3/ATP6AP1/MMP9/CCNA2/STAT6/NFATC3/PIK3R2/BCL2/HRAS/MYC/MAPK11	45
KEGG	hsa04140	Autophagy - animal	40/1588	141/8135	0.006745	0.0901	0.07525	CTSB/RRAGD/NRAS/MRAS/IGBP1/ATG16L2/TP53INP2/RRAGC/PIK3CD/PRKCQ/BCL2L1/EIF2AK4/RAB7B/PTEN/MTMR3/MAP1LC3B/RHEB/RAB1A/KRAS/RRAS2/ATG9A/SH3GLB1/ATG2B/GABARAPL1/BNIP3/C9orf72/PPP2CA/PRKCD/TSC2/GABARAP/IRS2/CTSD/STK11/MTMR14/DDIT4/ERN1/PIK3R2/BCL2/HRAS/ATG2A	40
KEGG	hsa05417	Lipid and atherosclerosis	57/1588	215/8135	0.007014	0.0901	0.07525	OLR1/HSPA1L/ABCA1/NRAS/MAPK13/STAT3/MAP2K7/PIK3CD/APAF1/PLCB1/BCL2L1/HSPA5/PLCB2/ARHGEF1/POU2F2/CAMK2G/HSP90B1/CASP1/MAP2K6/CD40/KRAS/MAP2K3/CCL2/MAPK14/TRAF2/MIB2/IRF3/LBP/NFE2L2/NCF1/PPP3CC/RXRA/CCL5/CALM1/BID/AGER/CASP8/NCF4/MYD88/TRAF3/CYP2A7/TNFRSF10A/PRKCA/TNFSF10/IKBKE/PTK2/FOS/MMP9/PPP3CB/NFATC3/ERN1/PIK3R2/ATF6/BCL2/HRAS/PPARG/MAPK11	57
KEGG	hsa00030	Pentose phosphate pathway	12/1588	30/8135	0.007688	0.09144	0.07637	TKT/TALDO1/FBP1/ALDOC/PFKP/PGD/RPIA/PFKM/PRPS1/GPI/PRPS2/PGLS	12
KEGG	hsa05225	Hepatocellular carcinoma	46/1588	168/8135	0.007865	0.09144	0.07637	TCF7L2/MGST1/CDK6/NRAS/FRAT1/PIK3CD/BCL2L1/TXNRD2/WNT5B/PTEN/SMARCD3/FZD5/GSTO1/RB1/SMARCC2/GSTM1/ACTG1/KRAS/GSTM4/SMAD3/SOS2/CDKN1A/LRP6/NQO1/NFE2L2/FRAT2/GSTM2/GRB2/ACTB/CCND1/CTNNB1/E2F2/TGFBR1/PRKCA/GSTP1/GSTM5/CDK4/DPF1/GADD45A/WNT10A/SMAD2/PIK3R2/HRAS/MYC/CDKN2A/WNT6	46
KEGG	hsa05416	Viral myocarditis	20/1588	60/8135	0.00794	0.09144	0.07637	ABL2/HLA-DPA1/HLA-DOA/HLA-DMA/ITGAL/CD40/ACTG1/RAC2/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/EIF4G3/SGCA/ACTB/CCND1/BID/CASP8/HLA-DQB1/EIF4G2	20
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	17/1588	49/8135	0.00897	0.09987	0.08341	PGM3/PMM1/GNPDA1/AMDHD2/UAP1L1/GPI/GMPPB/HEXB/GFPT1/GMDS/NPL/GALT/MPI/CYB5R3/HK3/RENBP/UAP1	17
KEGG	hsa04912	GnRH signaling pathway	28/1588	93/8135	0.009269	0.09987	0.08341	NRAS/ADCY3/MAPK13/MAP2K7/PLCB1/PLCB2/CAMK2G/ADCY9/PLA2G4B/MAP2K6/PTK2B/KRAS/MAP2K3/GNAS/SOS2/MAPK14/GNRH2/GRB2/CALM1/PRKCD/ITPR2/PRKCA/MAP3K3/PLA2G4E/CACNA1D/MMP2/HRAS/MAPK11	28
KEGG	hsa05205	Proteoglycans in cancer	54/1588	205/8135	0.009746	0.1017	0.08495	PLAU/NRAS/MRAS/NUDT16L1/MAPK13/FN1/ITGB5/STAT3/ITGAV/PIK3CD/TFAP4/SDC4/ARHGEF1/WNT5B/CAMK2G/FZD5/CBL/ACTG1/KRAS/PPP1R12B/RRAS2/SOS2/CDKN1A/MAPK14/GRB2/ACTB/TIAM1/CCND1/PTPN6/CTNNB1/CD63/ITPR2/EIF4B/SDC2/PRKCA/PAK1/PDCD4/PTK2/RPS6/PXN/PLAUR/MMP9/WNT10A/SMAD2/PIK3R2/MMP2/HRAS/ESR1/MYC/THBS1/CD44/MAPK11/WNT6/ITGA5	54
KEGG	hsa05014	Amyotrophic lateral sclerosis	89/1588	364/8135	0.01046	0.1058	0.08839	VDAC1/MAPK13/NUP214/OPTN/APAF1/TUBA1B/PSMD14/BCL2L1/HSPA5/UQCRB/TUBA1C/TOMM40/TUBB6/TUBB/PSMC2/MAP1LC3B/RAB5A/CAT/RAB1A/NUP210/TUBA4A/CASP1/TUBA1A/MAP2K6/ACTR10/SEH1L/ACTG1/MAP2K3/PSMD12/TUBB3/TUBB2A/NUP205/ACTR1B/FIG4/NDUFV3/DNAL4/GPX3/MAPK14/TRAF2/ATG2B/PSMA6/SDHD/PSMC1/PPP3CC/ACTB/KLC1/C9orf72/NRG3/PSMD3/PSMC3/SPG11/BID/VCP/UQCRC1/NCBP1/SETX/PSMD7/HNRNPA3/NDUFB1/TARDBP/DERL1/CHMP2B/DNAH1/DCTN3/CCS/PSMD1/PINK1/ATXN2L/PSMD2/NDUFA10/NUP43/ACTR1A/DNAI2/NUP62/NUP107/PSMD8/PPP3CB/NDUFA4L2/ERN1/TOMM40L/ATF6/BCL2/DCTN4/ATG2A/PSMD4/PSMD9/KIF5B/MAPK11/UBQLN1	89
KEGG	hsa03010	Ribosome	43/1588	158/8135	0.0111	0.109	0.09106	RPL13A/RPL22/RPS3A/RPL17/RPL5/RPL13/RPL28/RPL32/RPL4/MRPL10/RPL7/RPL7A/MRPL16/RPLP1/RPL23A/MRPS5/RPL11/RPL23/RPL9/RPS15A/RPS9/RPS4X/RPL37A/RPS2/RPS6/RPL12/RPS14/RPS3/RPS4Y2/RPS13/MRPL33/RPL35A/RPS23/MRPS9/RPL30/RPL21/RPLP2/RPL27A/RPL19/RPL31/RPS17/MRPS21/RPS20	43
KEGG	hsa05222	Small cell lung cancer	27/1588	92/8135	0.01489	0.1395	0.1165	CDK6/FN1/ITGAV/PIK3CD/APAF1/BCL2L1/PTEN/RB1/CDK2/CDKN1A/SKP2/TRAF2/RXRA/CCND1/CDKN1B/E2F2/TRAF3/ITGA3/PTGS2/PTK2/CDK4/COL4A5/GADD45A/CDKN2B/PIK3R2/BCL2/MYC	27
KEGG	hsa04110	Cell cycle	35/1588	126/8135	0.01504	0.1395	0.1165	CDKN1C/CDK6/YWHAH/CDKN2D/MCM6/RBL1/PLK1/RB1/PTTG2/CREBBP/YWHAQ/STAG1/SMAD3/MCM2/CDK2/CDKN1A/SKP2/PTTG1/CDC25B/CCND1/CDKN1B/E2F2/CCNB2/YWHAG/CCND2/SMC1A/CDK4/STAG2/GADD45A/CCNA2/CDKN2B/SMAD2/CDC20/MYC/CDKN2A	35
KEGG	hsa05220	Chronic myeloid leukemia	23/1588	76/8135	0.01626	0.1449	0.121	CDK6/NRAS/PIK3CD/BCL2L1/RB1/CBL/KRAS/SMAD3/SOS2/CDKN1A/STAT5A/GRB2/CCND1/CDKN1B/E2F2/TGFBR1/STAT5B/CDK4/GADD45A/PIK3R2/HRAS/MYC/CDKN2A	23
KEGG	hsa05223	Non-small cell lung cancer	22/1588	72/8135	0.01653	0.1449	0.121	CDK6/NRAS/STAT3/PIK3CD/EML4/RB1/KRAS/SOS2/CDKN1A/STAT5A/GRB2/RXRA/CCND1/E2F2/PRKCA/STAT5B/CDK4/GADD45A/PIK3R2/HRAS/KIF5B/CDKN2A	22
KEGG	hsa04210	Apoptosis	37/1588	136/8135	0.01766	0.1449	0.121	CTSB/NRAS/CASP2/PIK3CD/PMAIP1/APAF1/TUBA1B/BCL2L1/TUBA1C/CTSS/DFFB/TUBA4A/LMNA/TUBA1A/CTSH/ACTG1/KRAS/TRAF2/ACTB/LMNB2/BID/CASP8/CASP10/ITPR2/TNFRSF10A/MCL1/TNFSF10/PARP1/FOS/CTSD/MAP3K14/CTSO/GADD45A/ERN1/PIK3R2/BCL2/HRAS	37
KEGG	hsa00051	Fructose and mannose metabolism	12/1588	33/8135	0.01779	0.1449	0.121	ENOSF1/TPI1/PMM1/FBP1/ALDOC/PFKP/PFKM/GMPPB/GMDS/MPI/HK3/PFKFB3	12
KEGG	hsa03410	Base excision repair	12/1588	33/8135	0.01779	0.1449	0.121	MBD4/FEN1/MPG/POLD1/NEIL2/NEIL1/LIG1/PARP1/NTHL1/XRCC1/APEX2/POLL	12
KEGG	hsa05216	Thyroid cancer	13/1588	37/8135	0.01883	0.1497	0.125	TCF7L2/NRAS/TFG/NCOA4/KRAS/CDKN1A/RXRA/CCND1/CTNNB1/GADD45A/HRAS/PPARG/MYC	13
KEGG	hsa05219	Bladder cancer	14/1588	41/8135	0.01956	0.1505	0.1257	NRAS/UPK3A/RB1/KRAS/CDKN1A/CCND1/E2F2/CDK4/MMP9/MMP2/HRAS/MYC/THBS1/CDKN2A	14
KEGG	hsa05132	Salmonella infection	62/1588	249/8135	0.02029	0.1505	0.1257	TCF7L2/MAPK13/MAP2K7/PIK3CD/TUBA1B/TUBA1C/MLKL/RAB7B/TUBB6/TUBB/HSP90B1/RAB5A/TUBA4A/CASP1/ACTR3B/EXOC5/ARL8B/TUBA1A/STX10/MAP2K6/RALA/ANXA2/ACTR10/ACTG1/CASP4/MAP2K3/TUBB3/TUBB2A/CSE1L/ACTR1B/MAPK14/PIK3C2B/TRAF2/ARPC4/ACTB/KLC1/NAIP/CASP8/CTNNB1/MYD88/KPNA4/TNFRSF10A/TNFSF10/PAK1/NLRC4/S100A10/FOS/DCTN3/KPNA3/CYTH1/RPS3/DYNC2H1/CYFIP1/ACTR1A/M6PR/DYNC1I2/BCL2/DCTN4/HRAS/MYC/KIF5B/MAPK11	62
KEGG	hsa04152	AMPK signaling pathway	33/1588	120/8135	0.02065	0.1505	0.1257	SCD/SREBF1/PIK3CD/PPP2R5B/LEP/FBP1/PPP2R3A/EEF2K/PFKP/FASN/RHEB/PRKAG2/PPP2R5A/PFKM/PPARGC1A/PPP2CA/CCND1/SIRT1/MLYCD/TSC2/EEF2/CAB39/IRS2/CREB3/STK11/PRKAB2/ELAVL1/CCNA2/EIF4EBP1/PIK3R2/HMGCR/PPARG/PFKFB3	33
KEGG	hsa05203	Viral carcinogenesis	52/1588	204/8135	0.02073	0.1505	0.1257	CDK6/NRAS/YWHAH/GSN/RBPJ/STAT3/PIK3CD/PMAIP1/HDAC8/RBL1/HDAC10/RB1/RBPJL/HDAC9/CREBBP/KAT2A/KRAS/YWHAQ/CDK2/CDKN1A/CHD4/SKP2/TRAF2/TBP/IRF3/VAC14/STAT5A/PSMC1/GRB2/ACTN1/CCND1/CASP8/CDKN1B/TRAF3/UBE3A/YWHAG/CCND2/SNW1/STAT5B/SCIN/ATP6V0D1/CDK4/CREB3/GTF2B/PXN/CCNA2/CDKN2B/CDC20/PIK3R2/HRAS/CCR3/CDKN2A	52
KEGG	hsa04066	HIF-1 signaling pathway	30/1588	109/8135	0.02615	0.1851	0.1546	LDHA/ENO1/PGK1/STAT3/PIK3CD/ALDOC/PFKP/CAMK2G/TFRC/SLC2A1/CREBBP/PFKM/CDKN1A/MKNK1/ENO2/CDKN1B/TIMP1/LDHB/PRKCA/PDHB/ANGPT1/RPS6/SERPINE1/EIF4EBP1/HK3/CUL2/ENO3/PIK3R2/BCL2/PFKFB3	30
KEGG	hsa01240	Biosynthesis of cofactors	40/1588	153/8135	0.02659	0.1851	0.1546	MTHFD1L/DHRS3/NMNAT1/BCAT1/QPRT/ALPP/NADSYN1/PMM1/NMNAT3/VKORC1L1/PANK2/MTHFD2/GSS/GUSB/PPOX/ALPI/LIAS/GMPPB/LIPT1/NME3/COQ6/NQO1/AFMID/MPI/PPCDC/AKR1A1/MAT2A/MTHFD2L/COQ5/KYNU/NME1/MAT2B/COX15/PDXK/ALPL/SHMT2/MOCS1/MOCS2/PPCS/RDH11	40
KEGG	hsa00670	One carbon pool by folate	8/1588	20/8135	0.02793	0.1904	0.159	MTHFD1L/ATIC/MTHFD2/GART/AMT/TYMS/MTHFD2L/SHMT2	8
KEGG	hsa04370	VEGF signaling pathway	18/1588	59/8135	0.02885	0.1904	0.159	NRAS/MAPK13/PIK3CD/PLA2G4B/KRAS/RAC2/MAPK14/PPP3CC/PRKCA/HSPB1/PTGS2/PTK2/PXN/PLA2G4E/PPP3CB/PIK3R2/HRAS/MAPK11	18
KEGG	hsa05215	Prostate cancer	27/1588	97/8135	0.02933	0.1904	0.159	TCF7L2/PLAU/NRAS/PDGFB/ETV5/PIK3CD/PTEN/HSP90B1/RB1/CREBBP/KRAS/CDK2/SOS2/CDKN1A/GRB2/CCND1/CDKN1B/CTNNB1/E2F2/SPINT1/IL1R2/GSTP1/CREB3/MMP9/PIK3R2/BCL2/HRAS	27
KEGG	hsa00920	Sulfur metabolism	5/1588	10/8135	0.02964	0.1904	0.159	MPST/PAPSS2/IMPAD1/TST/SUOX	5
KEGG	hsa04935	Growth hormone synthesis, secretion and action	32/1588	119/8135	0.03041	0.1907	0.1593	NRAS/ADCY3/MAPK13/STAT3/PIK3CD/PLCB1/PLCB2/JUNB/ADCY9/MAP2K6/CREBBP/KRAS/MAP2K3/GNAS/SOS2/MAPK14/STAT5A/GRB2/ITPR2/PRKCA/SOCS1/PTK2/STAT5B/IRS2/FOS/CSH2/CREB3/CACNA1D/PIK3R2/SSTR2/HRAS/MAPK11	32
KEGG	hsa04380	Osteoclast differentiation	34/1588	128/8135	0.03116	0.1907	0.1593	ACP5/LILRB4/MAPK13/FCGR2B/MAP2K7/PIK3CD/JUNB/LILRB5/MAP2K6/TREM2/FCGR1A/CSF1R/LILRA1/LILRA3/MAPK14/TRAF2/NCF1/GRB2/PPP3CC/IFNAR1/NCF4/TGFBR1/SOCS1/FOS/MAP3K14/TNFRSF11A/PPP3CB/TEC/PIK3R2/SIRPB1/PPARG/BTK/MAPK11/LCK	34
KEGG	hsa04137	Mitophagy - animal	21/1588	72/8135	0.03141	0.1907	0.1593	NRAS/MRAS/OPTN/BCL2L1/RAB7B/USP15/TBC1D17/MAP1LC3B/SP1/KRAS/RRAS2/ATG9A/CITED2/GABARAPL1/BNIP3/CALCOCO2/CSNK2A2/GABARAP/PINK1/TOMM7/HRAS	21
KEGG	hsa04664	Fc epsilon RI signaling pathway	20/1588	68/8135	0.0323	0.1918	0.1602	NRAS/MAPK13/MAP2K7/PIK3CD/PLA2G4B/MAP2K6/KRAS/RAC2/MAP2K3/SOS2/INPP5D/MAPK14/ALOX5AP/GRB2/PRKCA/PLA2G4E/PIK3R2/HRAS/BTK/MAPK11	20
KEGG	hsa04012	ErbB signaling pathway	24/1588	85/8135	0.03273	0.1918	0.1602	NRAS/ABL2/MAP2K7/PIK3CD/CAMK2G/CBL/KRAS/SOS2/CDKN1A/STAT5A/GRB2/NRG3/NCK1/CBLB/CDKN1B/PRKCA/PAK1/PTK2/STAT5B/PAK2/EIF4EBP1/PIK3R2/HRAS/MYC	24
KEGG	hsa00562	Inositol phosphate metabolism	21/1588	73/8135	0.03625	0.2052	0.1714	IMPA2/PI4K2A/TPI1/PIK3CD/ITPKA/PLCB1/PLCB2/PTEN/MTMR3/PLCD1/MTMR2/FIG4/INPP5D/PIK3C2B/INPPL1/ITPK1/PI4KB/CDIPT/MTMR14/SYNJ2/ITPKB	21
KEGG	hsa04115	p53 signaling pathway	21/1588	73/8135	0.03625	0.2052	0.1714	CDK6/PMAIP1/APAF1/BCL2L1/PTEN/COP1/CDK2/CDKN1A/CCND1/BID/CASP8/CCNB2/TNFRSF10A/CCND2/TSC2/CDK4/GADD45A/SERPINE1/BCL2/THBS1/CDKN2A	21
KEGG	hsa05210	Colorectal cancer	24/1588	86/8135	0.03728	0.2059	0.172	TCF7L2/NRAS/RALGDS/PIK3CD/PMAIP1/RALA/KRAS/RAC2/SMAD3/SOS2/CDKN1A/APPL1/GRB2/CCND1/CTNNB1/MLH1/TGFBR1/FOS/GADD45A/SMAD2/PIK3R2/BCL2/HRAS/MYC	24
KEGG	hsa00770	Pantothenate and CoA biosynthesis	8/1588	21/8135	0.03761	0.2059	0.172	BCAT1/PANK2/CSAD/VNN1/VNN2/PPCDC/DPYD/PPCS	8
KEGG	hsa04625	C-type lectin receptor signaling pathway	28/1588	104/8135	0.04032	0.2172	0.1814	NRAS/MRAS/MAPK13/PIK3CD/CARD9/CASP1/KRAS/RRAS2/MAPK14/CLEC4E/PPP3CC/CLEC1B/CALM1/CBLB/PRKCD/CASP8/ITPR2/CLEC7A/PAK1/IKBKE/PTGS2/MAP3K14/CLEC4D/PPP3CB/NFATC3/PIK3R2/HRAS/MAPK11	28
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/1588	53/8135	0.04164	0.2207	0.1844	CLTCL1/PLCB1/PLCB2/ADCY9/ATP1B3/VDR/GNAS/SLC8A1/KL/PRKCA/ATP1A3/ATP1A1/ATP1B2/ESR1/RAB11A/ATP1B1	16
KEGG	hsa04917	Prolactin signaling pathway	20/1588	70/8135	0.0431	0.2235	0.1866	NRAS/MAPK13/STAT3/PIK3CD/KRAS/SOS2/MAPK14/STAT5A/GRB2/CCND1/GALT/CCND2/SOCS1/STAT5B/FOS/TNFRSF11A/PIK3R2/HRAS/ESR1/MAPK11	20
KEGG	hsa04216	Ferroptosis	13/1588	41/8135	0.04349	0.2235	0.1866	ACSL3/SLC11A2/PCBP2/SLC39A8/SLC40A1/GSS/MAP1LC3B/TFRC/PRNP/NCOA4/CP/SLC3A2/ACSL5	13
KEGG	hsa00480	Glutathione metabolism	17/1588	58/8135	0.04746	0.2371	0.198	MGST1/IDH2/GSS/PGD/GSTO1/GSTM1/GSTM4/RRM1/GPX3/GSTM2/ODC1/GSTP1/GSTM5/GSR/GSTK1/LAP3/OPLAH	17
KEGG	hsa05214	Glioma	21/1588	75/8135	0.04755	0.2371	0.198	CDK6/NRAS/PDGFB/PIK3CD/CAMK2G/PTEN/RB1/KRAS/SOS2/CDKN1A/GRB2/CALM1/CCND1/E2F2/PRKCA/CDK4/CAMK1D/GADD45A/PIK3R2/HRAS/CDKN2A	21
KEGG	hsa04910	Insulin signaling pathway	35/1588	137/8135	0.0492	0.2386	0.1993	NRAS/SREBF1/PIK3CD/FLOT1/FBP1/PHKA2/TRIP10/FASN/RHEB/CBL/PRKAG2/KRAS/SOS2/PHKG2/PTPN1/MKNK1/INPPL1/GRB2/PPARGC1A/PRKAR2A/CALM1/CBLB/PYGL/PPP1R3D/SOCS1/TSC2/IRS2/RAPGEF1/RPS6/PRKAB2/EIF4EBP1/HK3/PPP1R3F/PIK3R2/HRAS	35
KEGG	hsa00900	Terpenoid backbone biosynthesis	8/1588	22/8135	0.04929	0.2386	0.1993	IDI2/MVD/GGPS1/ACAT1/PCYOX1/HMGCS1/HMGCR/PDSS2	8
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	107/1588	476/8135	0.05449	0.2547	0.2127	VDAC1/NRAS/MAPK13/FRAT1/MAP2K7/OPTN/APAF1/TUBA1B/PLCB1/LRRK2/PSMD14/BCL2L1/HSPA5/PLCB2/UQCRB/TUBA1C/TOMM40/TUBB6/WNT5B/CAMK2G/TUBB/PSMC2/MAP1LC3B/RAB5A/CAT/RAB1A/FZD5/TUBA4A/TUBA1A/PRNP/MAP2K6/ATP2A2/ACTR10/KRAS/MAP2K3/PSMD12/TUBB3/TUBB2A/ACTR1B/FIG4/NDUFV3/LRP6/DNAL4/GPX3/MAPK14/TRAF2/ATG2B/PSMA6/FRAT2/SDHD/PSMC1/PPP3CC/KLC1/UBE2J1/C9orf72/CALM1/PSMD3/PSMC3/SPG11/BID/AGER/CASP8/UBA7/VCP/UQCRC1/CTNNB1/ITPR2/PSMD7/PRKCA/NDUFB1/CSNK1E/TARDBP/DERL1/PTGS2/UCHL1/CHMP2B/CSNK2A2/DLG4/DNAH1/DCTN3/CCS/PSMD1/CACNA1B/PINK1/ATXN2L/PSMD2/SLC25A4/NDUFA10/WNT10A/ACTR1A/DNAI2/PSMD8/PPP3CB/NDUFA4L2/ERN1/CACNA1D/TOMM40L/ATF6/BCL2/DCTN4/HRAS/ATG2A/PSMD4/PSMD9/KIF5B/MAPK11/WNT6	107
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/1588	15/8135	0.0549	0.2547	0.2127	GBGT1/B3GALNT1/GLA/HEXB/ST3GAL2/ST3GAL1	6
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/1588	15/8135	0.0549	0.2547	0.2127	HEXB/ST3GAL2/ST3GAL1/ST6GALNAC6/ST6GALNAC4/ST8SIA5	6
KEGG	hsa04610	Complement and coagulation cascades	23/1588	85/8135	0.05612	0.2568	0.2145	PLAU/VSIG4/PROS1/C1QC/C3AR1/C1QB/SERPINB2/C8G/CFB/CFHR5/CFD/C1R/C1QA/C5/SERPIND1/CD59/F13B/PLAUR/PROC/SERPINE1/CFHR2/THBD/F12	23
KEGG	hsa00531	Glycosaminoglycan degradation	7/1588	19/8135	0.06021	0.2718	0.227	IDS/GUSB/IDUA/HEXB/HYAL4/HYAL3/ARSB	7
KEGG	hsa04911	Insulin secretion	23/1588	86/8135	0.063	0.2806	0.2343	ADCY3/PLCB1/PLCB2/CAMK2G/ADCY9/ATP1B3/SLC2A1/SNAP25/GLP1R/GNAS/VAMP2/RAB3A/KCNN4/PRKCA/ATP1A3/ATP1A1/TRPM4/ATP1B2/CREB3/KCNMB1/ADCYAP1/CACNA1D/ATP1B1	23
KEGG	hsa05211	Renal cell carcinoma	19/1588	69/8135	0.06665	0.2929	0.2446	NRAS/PDGFB/PIK3CD/EPAS1/SLC2A1/CREBBP/KRAS/SOS2/CDKN1A/FLCN/GRB2/PAK1/PRCC/RAPGEF1/PAK2/CUL2/PIK3R2/HRAS/ETS1	19
KEGG	hsa04612	Antigen processing and presentation	21/1588	78/8135	0.06895	0.2991	0.2498	CTSB/LGMN/HSPA1L/HLA-DPA1/CIITA/HSPA5/HLA-DOA/HLA-DMA/CTSS/KLRC4/CALR/IFI30/CANX/HLA-DRA/HLA-DQA1/HLA-DPB1/NFYB/TAPBP/HLA-DQB1/CD8A/KIR3DL2	21
KEGG	hsa05150	Staphylococcus aureus infection	25/1588	96/8135	0.07134	0.3054	0.255	FPR3/FCGR2B/HLA-DPA1/CAMP/C1QC/C3AR1/HLA-DOA/HLA-DMA/C1QB/ITGAL/KRT9/FCGR1A/HLA-DRA/HLA-DQA1/HLA-DPB1/CFB/DEFB1/CFD/C1R/C1QA/C5/FPR1/HLA-DQB1/FCAR/KRT34	25
KEGG	hsa04062	Chemokine signaling pathway	46/1588	192/8135	0.07223	0.3054	0.255	CXCL9/GNG10/NRAS/ADCY3/STAT3/RASGRP2/PIK3CD/PLCB1/PLCB2/ADCY9/ARRB2/PTK2B/CXCL16/KRAS/RAC2/CCL2/SOS2/NCF1/CXCR3/GRB2/CCL5/TIAM1/PRKCD/CCR10/GNG2/FGR/CCL4L1/PAK1/CCL18/PTK2/STAT5B/PREX1/PXN/GSK3A/CCL13/CCL1/CXCR6/ITK/CXCL13/GNG11/GRK6/GNB1/PIK3R2/HRAS/CCR3/CXCR4	46
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1588	20/8135	0.07759	0.321	0.2681	DSE/CHST14/XYLT2/CHSY1/CHST7/CHST3/UST	7
KEGG	hsa04540	Gap junction	23/1588	88/8135	0.07848	0.321	0.2681	NRAS/ADCY3/PDGFB/TUBA1B/PLCB1/PLCB2/TUBA1C/TUBB6/TUBB/ADCY9/TUBA4A/TUBA1A/KRAS/TUBB3/TUBB2A/GNAS/SOS2/GRB2/MAP2K5/ITPR2/PRKCA/CSNK1D/HRAS	23
KEGG	hsa04070	Phosphatidylinositol signaling system	25/1588	97/8135	0.07902	0.321	0.2681	IMPA2/PI4K2A/PIK3CD/ITPKA/PLCB1/PLCB2/PTEN/MTMR3/IMPAD1/PLCD1/MTMR2/INPP5D/PIK3C2B/CDS1/INPPL1/CALM1/ITPK1/PI4KB/ITPR2/PRKCA/CDIPT/MTMR14/SYNJ2/PIK3R2/ITPKB	25
KEGG	hsa04918	Thyroid hormone synthesis	20/1588	75/8135	0.08105	0.321	0.2681	ADCY3/PLCB1/HSPA5/PLCB2/HSP90B1/ADCY9/ATP1B3/CANX/GNAS/GPX3/PDIA4/ITPR2/PRKCA/GSR/ATP1A3/ATP1A1/ATP1B2/CREB3/ASGR1/ATP1B1	20
KEGG	hsa04926	Relaxin signaling pathway	32/1588	129/8135	0.08136	0.321	0.2681	GNG10/NRAS/ADCY3/MAPK13/MAP2K7/PIK3CD/PLCB1/PLCB2/ADCY9/VEGFB/ARRB2/KRAS/GNAS/SOS2/GNA15/MAPK14/GRB2/GNG2/TGFBR1/PRKCA/FOS/CREB3/EDNRB/COL4A5/MMP9/SMAD2/GNG11/GNB1/PIK3R2/MMP2/HRAS/MAPK11	32
KEGG	hsa04672	Intestinal immune network for IgA production	14/1588	49/8135	0.08169	0.321	0.2681	HLA-DPA1/HLA-DOA/HLA-DMA/CD40/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/CCR10/HLA-DQB1/MAP3K14/IL15/ICOS/CXCR4	14
KEGG	hsa05213	Endometrial cancer	16/1588	58/8135	0.08617	0.3296	0.2752	TCF7L2/NRAS/PIK3CD/PTEN/CTNNA1/KRAS/SOS2/CDKN1A/GRB2/CCND1/CTNNB1/MLH1/GADD45A/PIK3R2/HRAS/MYC	16
KEGG	hsa05162	Measles	34/1588	139/8135	0.08722	0.3296	0.2752	HSPA1L/CDK6/FCGR2B/STAT3/PIK3CD/SLAMF1/APAF1/IL2RG/BCL2L1/EIF2AK4/EIF3H/CDK2/IRF3/TNFAIP3/STAT5A/IFNAR1/CBLB/CCND1/BID/CASP8/CDKN1B/CD3D/MYD88/TRAF3/IL2RB/CCND2/IKBKE/CSNK2A2/STAT5B/FOS/CDK4/CD3G/PIK3R2/BCL2	34
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	25/1588	98/8135	0.08724	0.3296	0.2752	F2RL1/ADCY3/MAPK13/PIK3CD/PLCB1/PRKCQ/PLCB2/CAMK2G/ADCY9/PLA2G4B/PRKCH/MAP2K6/TRPV2/MAP2K3/GNAS/MAPK14/PLA2G6/CALM1/PRKCD/ITPR2/PRKCA/PTGER2/PLA2G4E/PIK3R2/MAPK11	25
KEGG	hsa04010	MAPK signaling pathway	67/1588	294/8135	0.08782	0.3296	0.2752	HSPA1L/NRAS/MRAS/MAPK13/PDGFB/GNA12/MAP2K7/DUSP3/RASGRP2/MAP3K8/RASGRP3/PTPN7/MAP4K3/CACNA2D3/ECSIT/VEGFB/RASGRP4/DUSP6/PLA2G4B/MAP2K6/MAPKAPK5/ARRB2/KRAS/RAC2/MAP2K3/CSF1R/MAPK8IP3/RRAS2/SOS2/DUSP16/MAP3K6/MAPK14/TRAF2/MKNK1/GRB2/PPP3CC/DUSP1/CDC25B/RPS6KA1/MYD88/MAP2K5/TGFBR1/PRKCA/PAK1/MAP3K12/HSPB1/CACNG5/FOS/MAP3K14/ANGPT1/MAP3K3/CACNA1B/PAK2/MAP4K2/GADD45A/MAP4K4/PLA2G4E/RASA1/NF1/PPP3CB/PTPRR/NFATC3/CACNA1D/PPP5C/HRAS/MYC/MAPK11	67
KEGG	hsa00010	Glycolysis / Gluconeogenesis	18/1588	67/8135	0.08902	0.3296	0.2753	LDHA/ENO1/PGK1/TPI1/ACSS1/GALM/FBP1/ALDOC/PFKP/PFKM/GPI/ENO2/LDHB/PDHB/AKR1A1/ALDH3B1/HK3/ENO3	18
KEGG	hsa04971	Gastric acid secretion	20/1588	76/8135	0.09068	0.3296	0.2753	ADCY3/PLCB1/PLCB2/CAMK2G/ADCY9/ATP1B3/ACTG1/GNAS/CA2/ACTB/CALM1/ITPR2/PRKCA/ATP1A3/ATP1A1/ATP1B2/SLC9A4/SSTR2/ATP1B1/KCNJ15	20
KEGG	hsa01250	Biosynthesis of nucleotide sugars	11/1588	37/8135	0.09079	0.3296	0.2753	PGM3/PMM1/UAP1L1/GPI/GMPPB/GFPT1/GMDS/GALT/MPI/HK3/UAP1	11
KEGG	hsa04921	Oxytocin signaling pathway	37/1588	154/8135	0.09532	0.3423	0.2859	NRAS/ADCY3/PLCB1/PLCB2/CACNA2D3/EEF2K/CAMK2G/ADCY9/RGS2/PLA2G4B/PRKAG2/ACTG1/KRAS/PPP1R12B/GNAS/CDKN1A/PPP3CC/ACTB/CALM1/CCND1/MAP2K5/KCNJ14/ITPR2/PRKCA/CACNG5/PTGS2/EEF2/FOS/CAMK1D/PRKAB2/PLA2G4E/PPP3CB/NFATC3/CD38/KCNJ5/CACNA1D/HRAS	37
KEGG	hsa03050	Proteasome	13/1588	46/8135	0.09804	0.3484	0.2909	PSMD14/PSMC2/PSMD12/PSMA6/PSMC1/PSMD3/PSMC3/PSMD7/PSMD1/PSMD2/PSMD8/PSMD4/PSMD9	13
KEGG	hsa05130	Pathogenic Escherichia coli infection	46/1588	197/8135	0.1017	0.3575	0.2986	LPAR5/MAPK13/GNA12/TUBA1B/TUBA1C/MYO1F/ARHGEF1/TUBB6/TUBB/RAB1A/TUBA4A/CASP1/ACTR3B/TUBA1A/ACTG1/CASP4/TUBB3/ARHGEF2/TUBB2A/MYO1E/MAPK14/TRAF2/CLDN17/ARPC4/SLC9A3R1/MYO1C/ACTB/NCK1/NAIP/CASP8/PTPN6/MYD88/TNFRSF10A/MYO5A/TNFSF10/PAK1/FOS/CYTH1/PAK2/RPS3/CYFIP1/TMBIM6/WIPF2/CLDN9/MAPK11/SEC24A	46
KEGG	hsa01524	Platinum drug resistance	19/1588	73/8135	0.1062	0.3619	0.3022	MGST1/PIK3CD/PMAIP1/APAF1/BCL2L1/GSTO1/GSTM1/GSTM4/CDKN1A/GSTM2/BID/CASP8/MLH1/ATP7A/GSTP1/GSTM5/PIK3R2/BCL2/CDKN2A	19
KEGG	hsa05340	Primary immunodeficiency	11/1588	38/8135	0.1063	0.3619	0.3022	CIITA/IL2RG/IL7R/ADA/CD40/AIRE/CD3D/CD8A/ICOS/BTK/LCK	11
KEGG	hsa05135	Yersinia infection	33/1588	137/8135	0.1072	0.3619	0.3022	MAPK13/FN1/MAP2K7/PIK3CD/ARHGEF1/CASP1/ACTR3B/MAP2K6/PTK2B/ACTG1/RAC2/MAP2K3/CCL2/MAPK14/TRAF2/IRF3/ARPC4/ACTB/RPS6KA1/MYD88/DOCK1/NLRC4/PTK2/FOS/MEFV/PXN/CD8A/WIPF2/NFATC3/PIK3R2/MAPK11/LCK/ITGA5	33
KEGG	hsa05170	Human immunodeficiency virus 1 infection	49/1588	212/8135	0.1073	0.3619	0.3022	GNG10/NRAS/MAPK13/MAP2K7/PIK3CD/APOBEC3H/BCL2L1/TRIM5/CALR/CFL2/MAP2K6/PTK2B/KRAS/RAC2/MAP2K3/MAPK14/TRAF2/IRF3/AP1G2/PPP3CC/CALM1/AP1B1/BID/CASP8/TAPBP/GNG2/CD3D/MYD88/LIMK2/CCNB2/ITPR2/PRKCA/PAK1/PTK2/FOS/PXN/PAK2/CD3G/PPP3CB/CD247/BTRC/NFATC3/GNG11/GNB1/PIK3R2/BCL2/HRAS/MAPK11/CXCR4	49
KEGG	hsa04621	NOD-like receptor signaling pathway	43/1588	184/8135	0.1094	0.3649	0.3047	CTSB/VDAC1/MAPK13/CAMP/TRIP6/P2RX7/PLCB1/BCL2L1/PLCB2/CARD9/NLRX1/RBCK1/MAP1LC3B/PSTPIP1/NLRP1/CASP1/NAMPT/TRPV2/CASP4/CCL2/RNF31/MAPK14/TRAF2/IRF3/TNFAIP3/TP53BP1/GABARAPL1/IFNAR1/CCL5/NAIP/PRKCD/CASP8/MYD88/TRAF3/ITPR2/TXNIP/NLRC4/IKBKE/GABARAP/PANX1/MEFV/BCL2/MAPK11	43
KEGG	hsa04150	mTOR signaling pathway	37/1588	156/8135	0.1103	0.3649	0.3047	RRAGD/NRAS/RRAGC/SLC7A5/PIK3CD/WNT5B/ATP6V1E2/PTEN/MAPKAP1/RHEB/FZD5/WDR59/SEH1L/KRAS/SOS2/FLCN/LRP6/SKP2/GRB2/RPS6KA1/SLC3A2/EIF4B/RICTOR/PRKCA/LPIN3/TSC2/CAB39/RPS6/STK11/LPIN2/WNT10A/EIF4EBP1/WDR24/DDIT4/PIK3R2/HRAS/WNT6	37
KEGG	hsa04973	Carbohydrate digestion and absorption	13/1588	47/8135	0.1125	0.3682	0.3076	PIK3CD/PLCB1/PLCB2/SLC37A4/ATP1B3/SLC2A5/ATP1A3/ATP1A1/ATP1B2/HK3/CACNA1D/PIK3R2/ATP1B1	13
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1588	30/8135	0.1141	0.3702	0.3091	GLUL/ACSS1/CAT/PCCA/ACAT1/AMT/AFMID/MCEE/SHMT2	9
KEGG	hsa05321	Inflammatory bowel disease	17/1588	65/8135	0.1176	0.3775	0.3153	MAF/HLA-DPA1/STAT3/IL2RG/HLA-DOA/HLA-DMA/HLA-DRA/SMAD3/HLA-DQA1/HLA-DPB1/STAT4/HLA-DQB1/IL18RAP/IL18R1/SMAD2/FOXP3/STAT6	17
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1588	14/8135	0.1196	0.3803	0.3176	ST3GAL2/FUT8/ST3GAL1/B3GNT2/CHST2	5
KEGG	hsa04630	JAK-STAT signaling pathway	38/1588	162/8135	0.1209	0.381	0.3182	PIM1/PDGFB/STAT3/PIK3CD/IL2RG/BCL2L1/LEP/IL11RA/IL7R/CREBBP/SOS2/CDKN1A/CSF3R/STAT5A/GRB2/IFNAR1/STAT4/FHL1/CCND1/PTPN6/MCL1/IL2RB/CCND2/SOCS1/STAT5B/PTPN2/CSH2/IL22RA1/IL15/STAT6/CTF1/IL10RA/IL20RB/PIK3R2/BCL2/EPOR/HRAS/MYC	38
KEGG	hsa05230	Central carbon metabolism in cancer	18/1588	70/8135	0.1243	0.388	0.324	LDHA/NRAS/SLC7A5/PIK3CD/IDH2/PFKP/PTEN/SLC2A1/KRAS/PFKM/SLC16A3/LDHB/PDHB/HK3/SLC1A5/PIK3R2/HRAS/MYC	18
KEGG	hsa05142	Chagas disease	25/1588	102/8135	0.1256	0.3886	0.3245	MAPK13/C1QC/PIK3CD/PLCB1/PLCB2/C1QB/CALR/CCL2/GNAS/GNA15/MAPK14/PPP2CA/CCL5/CASP8/C1QA/CD3D/MYD88/TGFBR1/FOS/CD3G/SERPINE1/SMAD2/CD247/PIK3R2/MAPK11	25
KEGG	hsa04211	Longevity regulating pathway	22/1588	89/8135	0.1345	0.4088	0.3414	NRAS/ADCY3/PIK3CD/ADCY9/CAT/RHEB/PRKAG2/KRAS/APPL1/PPARGC1A/EHMT2/KL/SIRT1/TSC2/IRS2/CREB3/STK11/PRKAB2/EIF4EBP1/PIK3R2/HRAS/PPARG	22
KEGG	hsa04962	Vasopressin-regulated water reabsorption	12/1588	44/8135	0.1346	0.4088	0.3414	ADCY3/STX4/RAB5A/ADCY9/GNAS/VAMP2/ARHGDIA/CREB3/DYNC2H1/DYNC1I2/DCTN4/RAB11A	12
KEGG	hsa05212	Pancreatic cancer	19/1588	76/8135	0.1438	0.4288	0.3581	CDK6/RALGDS/STAT3/PIK3CD/BCL2L1/RB1/RALA/KRAS/RAC2/SMAD3/CDKN1A/CCND1/E2F2/TGFBR1/CDK4/GADD45A/SMAD2/PIK3R2/CDKN2A	19
KEGG	hsa03060	Protein export	7/1588	23/8135	0.1451	0.4288	0.3581	HSPA5/OXA1L/IMMP2L/SEC11A/SEC62/SRP54/SPCS3	7
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	7/1588	23/8135	0.1451	0.4288	0.3581	ATP1B3/CA2/ATP1A3/ATP1A1/SLC9A3/ATP1B2/ATP1B1	7
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	10/1588	36/8135	0.1488	0.436	0.3641	NMNAT1/QPRT/BST1/NADSYN1/NMNAT3/NAMPT/SIRT1/SIRT4/NNT/CD38	10
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1588	11/8135	0.1505	0.4372	0.3652	VKORC1L1/COQ6/NQO1/COQ5	4
KEGG	hsa04936	Alcoholic liver disease	33/1588	142/8135	0.1536	0.4395	0.367	TCF7L2/SCD/SREBF1/MAPK13/C1QC/MAP2K7/C3AR1/C1QB/FASN/PRKAG2/MAP2K6/MAP2K3/MAPK14/IRF3/LBP/PPARGC1A/CCND1/CASP8/C1QA/CTNNB1/C5/MYD88/TRAF3/SIRT1/MLYCD/LPIN3/IKBKE/IL17RA/MAP3K14/ACADVL/PRKAB2/LPIN2/MAPK11	33
KEGG	hsa05152	Tuberculosis	41/1588	180/8135	0.1539	0.4395	0.367	MAPK13/FCGR2B/HLA-DPA1/CAMP/CIITA/APAF1/CORO1A/CARD9/HLA-DOA/HLA-DMA/CTSS/CAMK2G/RAB5A/IRAK2/CREBBP/VDR/ATP6V0A1/FCGR1A/HLA-DRA/HLA-DQA1/MAPK14/HLA-DPB1/NFYB/LBP/CLEC4E/PPP3CC/CALM1/BID/CASP8/CASP10/MYD88/CLEC7A/HLA-DQB1/CTSD/ATP6V0D1/ATP6AP1/PPP3CB/EEA1/IL10RA/BCL2/MAPK11	41
KEGG	hsa04670	Leukocyte transendothelial migration	27/1588	114/8135	0.156	0.4416	0.3688	MAPK13/PIK3CD/CTNND1/ITGAL/PTK2B/CTNNA1/ACTG1/RAC2/MAPK14/CLDN17/TXK/NCF1/ACTB/ACTN1/NCF4/CTNNB1/PRKCA/PTK2/PECAM1/PXN/MMP9/ITK/PIK3R2/MMP2/CLDN9/MAPK11/CXCR4	27
KEGG	hsa05164	Influenza A	39/1588	171/8135	0.1589	0.4416	0.3688	VDAC1/CDK6/HLA-DPA1/CIITA/PIK3CD/APAF1/NLRX1/HLA-DOA/HLA-DMA/CASP1/DNAJC3/CREBBP/ACTG1/HLA-DRA/CCL2/HLA-DQA1/HLA-DPB1/IRF3/DNAJB1/ACTB/IFNAR1/PABPN1/CCL5/CALCOCO2/BID/CASP8/MYD88/TRAF3/TNFRSF10A/PRKCA/TNFSF10/HLA-DQB1/IKBKE/KPNA6/CDK4/XPO1/SLC25A4/PIK3R2/RAB11A	39
KEGG	hsa04071	Sphingolipid signaling pathway	28/1588	119/8135	0.1596	0.4416	0.3688	NRAS/MAPK13/GNA12/PIK3CD/SGPL1/PPP2R5B/PLCB1/PLCB2/PPP2R3A/PTEN/PPP2R5A/KRAS/RAC2/MAPK14/TRAF2/PPP2CA/BID/PRKCA/DEGS1/CTSD/NSMAF/S1PR3/S1PR4/PIK3R2/BCL2/HRAS/SPTLC2/MAPK11	28
KEGG	hsa05160	Hepatitis C	36/1588	157/8135	0.1616	0.4416	0.3688	CD81/CDK6/NRAS/YWHAH/STAT3/PIK3CD/NR1H3/APAF1/EIF2AK4/RB1/EIF3E/KRAS/YWHAQ/CDK2/SOS2/CDKN1A/TRAF2/IRF3/CLDN17/GRB2/IFNAR1/RXRA/PPP2CA/CCND1/BID/CASP8/CTNNB1/E2F2/TRAF3/YWHAG/IKBKE/CDK4/PIK3R2/HRAS/MYC/CLDN9	36
KEGG	hsa04979	Cholesterol metabolism	13/1588	50/8135	0.1626	0.4416	0.3688	VDAC1/ABCA1/NPC1/APOE/NPC2/PLTP/LDLRAP1/LCAT/APOC1/CETP/OSBPL5/APOH/SOAT1	13
KEGG	hsa05110	Vibrio cholerae infection	13/1588	50/8135	0.1626	0.4416	0.3688	ADCY3/ATP6V1E2/ADCY9/KDELR2/ACTG1/ATP6V0A1/GNAS/PDIA4/ACTB/TJP2/PRKCA/ATP6V0D1/ATP6AP1	13
KEGG	hsa05017	Spinocerebellar ataxia	33/1588	143/8135	0.1641	0.4418	0.369	VDAC1/RBPJ/PIK3CD/PLCB1/PSMD14/PLCB2/PSMC2/RBPJL/SP1/ATP2A2/PSMD12/TRAF2/ATG2B/TBP/PSMA6/PSMC1/PSMD3/PSMC3/ITPR2/PSMD7/PRKCA/GRIN3B/PSMD1/GTF2B/ATXN2L/PSMD2/SLC25A4/PSMD8/ERN1/PIK3R2/ATG2A/PSMD4/PSMD9	33
KEGG	hsa04015	Rap1 signaling pathway	47/1588	210/8135	0.1654	0.4418	0.369	SIPA1L2/LPAR5/NRAS/RALGDS/ADCY3/MRAS/MAPK13/PDGFB/RASGRP2/PIK3CD/RGS14/PLCB1/PLCB2/RASGRP3/CTNND1/ITGAL/ADCY9/RAPGEF6/VEGFB/MAP2K6/RALA/ACTG1/KRAS/RAC2/MAP2K3/CSF1R/GNAS/MAPK14/ACTB/CALM1/TIAM1/ADORA2B/CTNNB1/FPR1/PRKCA/SIPA1L3/PRKD3/RAPGEF1/ANGPT1/TLN2/PRKD2/DOCK4/PIK3R2/SKAP1/HRAS/THBS1/MAPK11	47
KEGG	hsa05020	Prion disease	60/1588	273/8135	0.1671	0.443	0.3699	VDAC1/HSPA1L/MAPK13/C1QC/PIK3CD/APAF1/TUBA1B/PSMD14/HSPA5/UQCRB/TUBA1C/TUBB6/C1QB/TUBB/PSMC2/TUBA4A/TUBA1A/PRNP/RAC2/C8G/PSMD12/TUBB3/TUBB2A/NDUFV3/MAPK14/STIP1/PSMA6/NCF1/SDHD/PSMC1/PPP3CC/KLC1/CCL5/PSMD3/PSMC3/PRKCD/NCF4/C1QA/UQCRC1/C5/ITPR2/PSMD7/NDUFB1/GRIN3B/CSNK2A2/PSMD1/CREB3/CACNA1B/PSMD2/SLC25A4/NDUFA10/PSMD8/PPP3CB/NDUFA4L2/CACNA1D/PIK3R2/PSMD4/PSMD9/KIF5B/MAPK11	60
KEGG	hsa04929	GnRH secretion	16/1588	64/8135	0.1695	0.4458	0.3723	NRAS/SPP1/PIK3CD/PLCB1/PLCB2/GABBR1/ARRB2/KRAS/GNRH2/KCNN4/ITPR2/PRKCA/KCNJ5/CACNA1D/PIK3R2/HRAS	16
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1588	24/8135	0.1722	0.4476	0.3738	EXTL2/EXTL3/HS3ST1/XYLT2/GLCE/EXT1/HS3ST3B1	7
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1588	106/8135	0.1729	0.4476	0.3738	ADCY3/GNA12/PLCB1/PLCB2/ARHGEF1/ADCY9/SP1/MAFB/NACA/ARRB2/VDR/GNAS/CDKN1A/LRP6/SLC9A3R1/MEF2A/RXRA/BGLAP/KL/ITPR2/PRKCA/FOS/CREB3/BCL2/PDE4D	25
KEGG	hsa04514	Cell adhesion molecules	34/1588	149/8135	0.1777	0.4536	0.3789	ALCAM/HLA-DPA1/CD276/ITGAV/NTNG2/SELL/HLA-DOA/SDC4/HLA-DMA/ITGAL/CD2/CD40/PTPRM/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/CLDN17/L1CAM/ICAM3/CDH2/CD6/SDC2/HLA-DQB1/CD226/PECAM1/ICAM2/PDCD1LG2/CD8A/CD58/CD274/NFASC/ICOS/CLDN9	34
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	23/1588	97/8135	0.1779	0.4536	0.3789	FCGR2B/GSN/PIK3CD/ACTR3B/CFL2/PLA2G4B/RAC2/FCGR1A/INPP5D/INPPL1/BIN1/PLA2G6/ARPC4/NCF1/PRKCD/DOCK1/LIMK2/PRKCA/PAK1/SCIN/PLA2G4E/MARCKSL1/PIK3R2	23
KEGG	hsa04130	SNARE interactions in vesicular transport	9/1588	33/8135	0.18	0.4554	0.3803	STX4/GOSR1/STX11/VAMP2/SNAP23/STX6/USE1/VAMP3/STX16	9
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	43/1588	194/8135	0.1966	0.4936	0.4123	TCF7L2/GNG10/CDK6/NRAS/MAPK13/PDGFB/STAT3/MAP2K7/PIK3CD/MAP1LC3B/RB1/MAP2K6/CREBBP/KRAS/CDKN1A/MAPK14/TRAF2/IRF3/PPP3CC/IFNAR1/CALM1/CCND1/BID/CASP8/GNG2/CTNNB1/E2F2/TRAF3/ITPR2/IKBKE/PTGS2/FOS/CDK4/PREX1/PPP3CB/NFATC3/GNG11/GNB1/PIK3R2/HRAS/CCR3/MYC/MAPK11	43
KEGG	hsa05165	Human papillomavirus infection	71/1588	331/8135	0.2011	0.5006	0.4181	TCF7L2/HES4/COL9A2/CDK6/NRAS/FN1/ITGB5/RBPJ/SPP1/ITGAV/PIK3CD/PPP2R5B/PPP2R3A/RBL1/WNT5B/HES6/ATP6V1E2/PTEN/RHEB/FZD5/RB1/RBPJL/CREBBP/PPP2R5A/KRAS/ATP6V0A1/GNAS/CDK2/NOTCH2/SOS2/CDKN1A/CHD4/TBP/IRF3/SLC9A3R1/PSMC1/GRB2/IFNAR1/PPP2CA/CCND1/CASP8/CDKN1B/CTNNB1/TRAF3/NOTCH4/COL2A1/ITGA3/UBE3A/TUBG1/CCND2/IKBKE/PTGS2/TSC2/PTK2/BCAP31/ATP6V0D1/MFNG/CDK4/CREB3/PXN/COL4A5/ATP6AP1/CRB3/CCNA2/WNT10A/EIF4EBP1/PIK3R2/HRAS/THBS1/WNT6/ITGA5	71
KEGG	hsa04350	TGF-beta signaling pathway	22/1588	94/8135	0.2024	0.5006	0.4181	RBL1/SMAD6/NBL1/SP1/HAMP/CREBBP/SMAD3/SMAD7/RGMA/ID3/PPP2CA/TGFBR1/SMAD5/SMAD1/NODAL/BMP2/ZFYVE16/CDKN2B/SMAD2/INHBE/MYC/THBS1	22
KEGG	hsa00983	Drug metabolism - other enzymes	19/1588	80/8135	0.2041	0.5012	0.4186	MGST1/HPRT1/TK2/GUSB/GSTO1/CDA/GSTM1/GSTM4/RRM1/NME3/GSTM2/CYP2A7/DUT/TK1/GSTP1/MPO/GSTM5/DPYD/NME1	19
KEGG	hsa00513	Various types of N-glycan biosynthesis	10/1588	39/8135	0.2173	0.525	0.4384	MGAT4A/ALG9/MAN2A2/MAN1C1/HEXB/MAN1A2/FUT8/ALG12/RPN1/MGAT1	10
KEGG	hsa04915	Estrogen signaling pathway	31/1588	138/8135	0.2176	0.525	0.4384	HSPA1L/NRAS/ADCY3/NCOA1/PIK3CD/PLCB1/PLCB2/GABBR1/HSP90B1/ADCY9/SP1/KRT9/KRAS/GNAS/SOS2/GRB2/CALM1/PRKCD/ITPR2/RARA/FOS/CTSD/CREB3/MMP9/KRT34/KCNJ5/PIK3R2/BCL2/MMP2/HRAS/ESR1	31
KEGG	hsa04310	Wnt signaling pathway	37/1588	167/8135	0.2185	0.525	0.4384	TCF7L2/PRICKLE1/FRAT1/PLCB1/PLCB2/WNT5B/CAMK2G/FZD5/CREBBP/SERPINF1/RAC2/RSPO2/SMAD3/TLE4/PPARD/LRP6/FRAT2/PPP3CC/WIF1/CCND1/NOTUM/CTNNB1/PRKCA/PORCN/CCND2/CSNK1E/TBL1X/CSNK2A2/GPC4/WNT10A/PRICKLE2/PPP3CB/BTRC/NFATC3/MYC/WNT6/LGR6	37
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/1588	100/8135	0.2215	0.5284	0.4413	CXCL9/IL2RG/CSF1R/CCL2/TNFRSF10C/CXCR3/CCL5/CCR10/TNFRSF10A/CCL4L1/TNFSF10/IL2RB/IL18RAP/CCL18/IL18R1/IL22RA1/CCL13/CCL1/CXCL13/IL10RA/IL20RB/CCR3/CXCR4	23
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1588	26/8135	0.2323	0.534	0.446	PIGZ/PIGX/PIGV/PIGL/PIGM/MPPE1/GPAA1	7
KEGG	hsa00790	Folate biosynthesis	7/1588	26/8135	0.2323	0.534	0.446	ALPP/ALPI/PCBD2/TPH1/ALPL/MOCS1/MOCS2	7
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	46/1588	212/8135	0.2325	0.534	0.446	MGST1/NRAS/ADCY3/EPHX1/STAT3/PIK3CD/PAQR7/AIP/HSP90B1/ADCY9/GSTO1/RB1/ARRB2/VDR/GSTM1/KRAS/GSTM4/GNAS/NOTCH2/SOS2/PTGES3/STAT5A/GSTM2/GRB2/RXRA/CCND1/RPS6KA1/KPNA4/PRKCA/IKBKE/GSTM5/KPNA6/STAT5B/CYP1B1/FOS/KPNA3/CREB3/CACNA1B/DLL1/EIF4EBP1/CACNA1D/PIK3R2/BCL2/HRAS/ESR1/MYC	46
KEGG	hsa05140	Leishmaniasis	18/1588	77/8135	0.2335	0.534	0.446	MAPK13/HLA-DPA1/HLA-DOA/HLA-DMA/FCGR1A/HLA-DRA/HLA-DQA1/MAPK14/HLA-DPB1/NCF1/NCF4/PTPN6/MYD88/HLA-DQB1/PTGS2/FOS/MARCKSL1/MAPK11	18
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1588	77/8135	0.2335	0.534	0.446	TCF7L2/DSC2/ITGB5/ITGAV/CACNA2D3/LMNA/ATP2A2/CTNNA1/ACTG1/SLC8A1/SGCA/ACTB/CDH2/CTNNB1/ITGA3/CACNG5/CACNA1D/ITGA5	18
KEGG	hsa03250	Viral life cycle - HIV-1	15/1588	63/8135	0.2361	0.534	0.446	APOBEC3H/TRIM5/CREBBP/KAT2A/SUPT4H1/MAP1S/CDK9/SERINC3/RAN/XPO1/MAP1A/TSG101/TNPO3/ELL3/CXCR4	15
KEGG	hsa03450	Non-homologous end-joining	4/1588	13/8135	0.238	0.534	0.446	FEN1/POLM/XRCC6/POLL	4
KEGG	hsa04146	Peroxisome	19/1588	82/8135	0.2381	0.534	0.446	ACSL3/IDH2/PECR/ECH1/CAT/PRDX1/PEX11B/PEX16/ACOT8/MLYCD/ACSL5/PXMP4/PEX7/GSTK1/HACL1/FAR1/AGPS/PEX11A/DHRS4	19
KEGG	hsa05202	Transcriptional misregulation in cancer	42/1588	193/8135	0.2382	0.534	0.446	PLAU/ZBTB16/MAF/ETV5/SLC45A3/HHEX/BCL2L1/BMP2K/NUPR1/DUSP6/SP1/CD40/FCGR1A/CSF1R/LMO2/CDK9/CDKN1A/FUT8/RXRA/FLI1/CDKN1B/CEBPE/SPINT1/IL2RB/CCND2/IL1R2/MPO/PTK2/PRCC/RARA/ASPSCR1/TCF3/SMAD1/GADD45A/BMI1/MMP9/CCNA2/TAF15/PPARG/BCL11B/MYC/PAX7	42
KEGG	hsa05310	Asthma	8/1588	31/8135	0.2471	0.5503	0.4596	HLA-DPA1/HLA-DOA/HLA-DMA/CD40/HLA-DRA/HLA-DQA1/HLA-DPB1/HLA-DQB1	8
KEGG	hsa03022	Basal transcription factors	11/1588	45/8135	0.2518	0.5559	0.4643	TAF5/TAF1/TAF1L/TBP/TAF7/TAF8/ERCC3/GTF2IRD1/TAF9/GTF2B/TAF15	11
KEGG	hsa04114	Oocyte meiosis	29/1588	131/8135	0.2536	0.5559	0.4643	ADCY3/YWHAH/MAPK13/PPP2R5B/CAMK2G/PLK1/ADCY9/PTTG2/PPP2R5A/YWHAQ/CDK2/MAPK14/SPDYC/PPP3CC/PTTG1/PPP2CA/CALM1/RPS6KA1/CCNB2/ITPR2/YWHAG/CPEB4/SMC1A/MOS/AURKA/CDC20/PPP3CB/BTRC/MAPK11	29
KEGG	hsa04922	Glucagon signaling pathway	24/1588	107/8135	0.256	0.5559	0.4643	LDHA/PLCB1/PLCB2/FBP1/PFKP/CAMK2G/PHKA2/SLC2A1/PRKAG2/CREBBP/PFKM/GNAS/PHKG2/PPP3CC/PPARGC1A/CALM1/ITPR2/SIRT1/LDHB/PYGL/PDHB/CREB3/PRKAB2/PPP3CB	24
KEGG	hsa04668	TNF signaling pathway	25/1588	112/8135	0.2588	0.5559	0.4643	MAPK13/MAP2K7/PIK3CD/MAP3K8/MLKL/JUNB/MAP2K6/MAP2K3/CCL2/MAPK14/TRAF2/TNFAIP3/CCL5/CASP8/CASP10/TRAF3/PTGS2/FOS/MAP3K14/IL18R1/CREB3/MMP9/IL15/PIK3R2/MAPK11	25
KEGG	hsa03030	DNA replication	9/1588	36/8135	0.259	0.5559	0.4643	RNASEH2B/MCM6/FEN1/MCM2/POLD1/LIG1/RNASEH2C/PRIM2/RPA4	9
KEGG	hsa00510	N-Glycan biosynthesis	12/1588	50/8135	0.2597	0.5559	0.4643	MGAT4A/ALG9/MAN2A2/ST6GAL1/MAN1C1/MAN1A2/FUT8/ALG6/DOLK/ALG12/RPN1/MGAT1	12
KEGG	hsa00511	Other glycan degradation	5/1588	18/8135	0.2656	0.5596	0.4673	GBA/MAN2C1/HEXB/GBA2/NEU1	5
KEGG	hsa00564	Glycerophospholipid metabolism	22/1588	98/8135	0.2665	0.5596	0.4673	PLA2G2D/ETNK1/MBOAT1/PISD/TAZ/PLA2G4B/CHKB/PLA2G15/PTDSS2/LCAT/CHPT1/CDS1/PLA2G6/PLD4/LPIN3/GPD1L/AGPAT2/CDIPT/LPIN2/PLA2G4E/PTDSS1/LYPLA2	22
KEGG	hsa05231	Choline metabolism in cancer	22/1588	98/8135	0.2665	0.5596	0.4673	NRAS/RALGDS/PDGFB/PIK3CD/RHEB/SP1/PLA2G4B/CHKB/KRAS/RAC2/SLC44A2/SOS2/CHPT1/GRB2/PRKCA/TSC2/FOS/SLC22A5/PLA2G4E/EIF4EBP1/PIK3R2/HRAS	22
KEGG	hsa04728	Dopaminergic synapse	29/1588	132/8135	0.2681	0.5596	0.4673	GNG10/MAPK13/PPP2R5B/PLCB1/PLCB2/PPP2R3A/CAMK2G/ARRB2/PPP2R5A/GNAS/MAPK14/PPP3CC/PPP2CA/CALM1/GNG2/ITPR2/PRKCA/FOS/CREB3/CACNA1B/GSK3A/CLOCK/PPP3CB/GNG11/KCNJ5/GNB1/CACNA1D/KIF5B/MAPK11	29
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1588	79/8135	0.2706	0.5604	0.4681	GAS6/NRAS/PDGFB/STAT3/PIK3CD/AXL/BCL2L1/PTEN/KRAS/SOS2/GRB2/PRKCA/RPS6/EIF4EBP1/NF1/PIK3R2/BCL2/HRAS	18
KEGG	hsa04978	Mineral absorption	14/1588	60/8135	0.2724	0.5604	0.4681	SLC11A2/SLC40A1/ATP1B3/VDR/SLC26A6/SLC8A1/MT1G/ATP7A/ATP1A3/ATP1A1/SLC9A3/ATP1B2/CYBRD1/ATP1B1	14
KEGG	hsa05224	Breast cancer	32/1588	147/8135	0.2735	0.5604	0.4681	TCF7L2/CDK6/NRAS/NCOA1/FRAT1/PIK3CD/WNT5B/PTEN/FZD5/RB1/SP1/KRAS/NOTCH2/SOS2/CDKN1A/LRP6/FRAT2/GRB2/CCND1/CTNNB1/E2F2/NOTCH4/FOS/CDK4/GADD45A/DLL1/WNT10A/PIK3R2/HRAS/ESR1/MYC/WNT6	32
KEGG	hsa04620	Toll-like receptor signaling pathway	23/1588	104/8135	0.2862	0.582	0.4861	CXCL9/MAPK13/SPP1/MAP2K7/PIK3CD/MAP3K8/MAP2K6/CD40/MAP2K3/CD80/MAPK14/IRF3/LBP/IFNAR1/CCL5/CASP8/MYD88/TRAF3/CCL4L1/IKBKE/FOS/PIK3R2/MAPK11	23
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	9/1588	37/8135	0.2875	0.582	0.4861	PIK3CD/ATP1B3/KRAS/PRKCA/ATP1A3/ATP1A1/ATP1B2/PIK3R2/ATP1B1	9
KEGG	hsa05226	Gastric cancer	32/1588	149/8135	0.302	0.6061	0.5062	TCF7L2/NRAS/FRAT1/PIK3CD/WNT5B/FZD5/RB1/CTNNA1/KRAS/SMAD3/CDK2/SOS2/CDKN1A/LRP6/FRAT2/GRB2/RXRA/CCND1/CDKN1B/CTNNB1/E2F2/MLH1/TGFBR1/GADD45A/WNT10A/CDKN2B/SMAD2/PIK3R2/BCL2/HRAS/MYC/WNT6	32
KEGG	hsa04520	Adherens junction	16/1588	71/8135	0.303	0.6061	0.5062	TCF7L2/CTNND1/CREBBP/CTNNA1/ACTG1/RAC2/PTPRM/SMAD3/PTPN1/ACTB/ACTN1/PTPN6/CTNNB1/TGFBR1/CSNK2A2/ACP1	16
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	5/1588	19/8135	0.3071	0.6106	0.5099	BCAT1/IDH2/GOT1/IDH3A/IDH3B	5
KEGG	hsa05330	Allograft rejection	9/1588	38/8135	0.3168	0.6238	0.521	HLA-DPA1/HLA-DOA/HLA-DMA/CD40/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/HLA-DQB1	9
KEGG	hsa04213	Longevity regulating pathway - multiple species	14/1588	62/8135	0.3175	0.6238	0.521	HSPA1L/NRAS/ADCY3/PIK3CD/EIF4EBP2/ADCY9/CAT/PRKAG2/KRAS/SIRT1/IRS2/PRKAB2/PIK3R2/HRAS	14
KEGG	hsa00730	Thiamine metabolism	4/1588	15/8135	0.3338	0.6521	0.5446	ALPP/ALPI/ALPL/ACP1	4
KEGG	hsa05016	Huntington disease	63/1588	306/8135	0.3379	0.6561	0.548	SLC1A3/CLTCL1/VDAC1/TGM2/MAP2K7/APAF1/TUBA1B/PLCB1/PSMD14/PLCB2/UQCRB/TUBA1C/TUBB6/TUBB/PSMC2/TUBA4A/TUBA1A/SP1/CREBBP/ACTR10/PSMD12/TUBB3/TUBB2A/ACTR1B/NDUFV3/DNAL4/GPX3/TRAF2/ATG2B/TBP/PSMA6/SDHD/PSMC1/KLC1/PPARGC1A/PSMD3/PSMC3/CASP8/UQCRC1/PSMD7/NDUFB1/POLR2D/DLG4/DNAH1/DCTN3/PSMD1/CREB3/CACNA1B/PSMD2/SLC25A4/NDUFA10/ACTR1A/DNAI2/PSMD8/NDUFA4L2/ERN1/POLR2H/DCTN4/ATG2A/PPARG/PSMD4/PSMD9/KIF5B	63
KEGG	hsa04120	Ubiquitin mediated proteolysis	30/1588	142/8135	0.3453	0.6666	0.5567	UBE2O/CBL/SYVN1/AIRE/HERC3/COP1/UBE2E3/SKP2/UBE4B/SAE1/UBE2Q2/UBE3B/UBE2J1/CBLB/UBA7/UBE2Z/UBE3A/UBA3/SOCS1/UBE3C/HUWE1/UBE2A/CDC20/CUL2/FBXW7/BTRC/CUL7/WWP2/DET1/UBE4A	30
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	17/1588	78/8135	0.3482	0.6684	0.5582	MGST1/EPHX1/GSTO1/DHDH/GSTM1/GSTM4/AKR7A3/CYP2S1/GSTM2/HSD11B1/CYP2A7/CBR3/GSTP1/GSTM5/CYP1B1/ALDH3B1/GSTK1	17
KEGG	hsa05323	Rheumatoid arthritis	20/1588	93/8135	0.3532	0.6727	0.5618	ACP5/HLA-DPA1/HLA-DOA/HLA-DMA/ATP6V1E2/ITGAL/ATP6V0A1/HLA-DRA/CD80/CCL2/HLA-DQA1/HLA-DPB1/CCL5/HLA-DQB1/FOS/ATP6V0D1/ANGPT1/ATP6AP1/TNFRSF11A/IL15	20
KEGG	hsa04925	Aldosterone synthesis and secretion	21/1588	98/8135	0.3545	0.6727	0.5618	ADCY3/PLCB1/PLCB2/CAMK2G/ADCY9/ATP1B3/GNAS/CALM1/ITPR2/PRKCA/PRKD3/ATP1A3/ATP1A1/ATP1B2/CREB3/CAMK1D/PRKD2/KCNJ5/CACNA1D/KCNK3/ATP1B1	21
KEGG	hsa04810	Regulation of actin cytoskeleton	45/1588	218/8135	0.3626	0.6842	0.5714	LPAR5/NRAS/MRAS/FN1/ITGB5/PDGFB/GNA12/GSN/ITGAV/PIK3CD/ARHGEF1/ITGAL/ACTR3B/CFL2/ACTG1/KRAS/RAC2/PPP1R12B/ITGAE/RRAS2/FGD3/SOS2/ARPC4/ACTB/ACTN1/TIAM1/DOCK1/LIMK2/ITGA3/SSH2/PAK1/PTK2/SSH1/DIAPH2/SCIN/MOS/PXN/PAK2/CYFIP1/PIK3R2/HRAS/CHRM2/ITGA5/CXCR4/TMSB4Y	45
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	15/1588	69/8135	0.3663	0.6852	0.5722	MGST1/EPHX1/SULT1A2/GSTO1/GSTM1/GSTM4/GSTM2/HSD11B1/SULT1A1/CYP2A7/PTGS2/GSTP1/GSTM5/CYP1B1/GSTK1	15
KEGG	hsa01523	Antifolate resistance	7/1588	30/8135	0.3672	0.6852	0.5722	FOLR3/ATIC/ABCC3/GART/TYMS/SHMT2/SLC19A1	7
KEGG	hsa04722	Neurotrophin signaling pathway	25/1588	119/8135	0.3757	0.6971	0.5822	NRAS/MAPK13/MAP2K7/PIK3CD/CAMK2G/SH2B1/IRAK2/KRAS/SOS2/MAPK14/PRDM4/GRB2/IRAK3/CALM1/PRKCD/RPS6KA1/MAP2K5/NFKBIE/ARHGDIA/RAPGEF1/MAP3K3/PIK3R2/BCL2/HRAS/MAPK11	25
KEGG	hsa00360	Phenylalanine metabolism	4/1588	16/8135	0.3827	0.7026	0.5868	IL4I1/GOT1/MIF/ALDH3B1	4
KEGG	hsa05144	Malaria	11/1588	50/8135	0.3829	0.7026	0.5868	CD81/HBB/HBA2/ITGAL/CD40/CCL2/MYD88/SDC2/PECAM1/KLRB1/THBS1	11
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	31/1588	150/8135	0.3927	0.7167	0.5985	ADCY3/MAPK13/TPM4/PPP2R5B/PLCB1/PLCB2/PPP2R3A/CACNA2D3/CAMK2G/ADCY9/ATP1B3/ATP2A2/PPP2R5A/GNAS/KCNE1/MAPK14/SLC8A1/PPP2CA/CALM1/PRKCA/CACNG5/ATP1A3/ATP1A1/ATP1B2/CREB3/SCN4B/TPM1/CACNA1D/BCL2/ATP1B1/MAPK11	31
KEGG	hsa04710	Circadian rhythm	7/1588	31/8135	0.4022	0.7301	0.6098	PRKAG2/CSNK1E/CRY2/CSNK1D/PRKAB2/CLOCK/BTRC	7
KEGG	hsa00330	Arginine and proline metabolism	11/1588	51/8135	0.4102	0.7361	0.6148	ALDH18A1/GOT1/P4HA2/SMOX/P4HA3/GATM/ODC1/P4HA1/CKB/CNDP2/LAP3	11
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	27/1588	131/8135	0.4102	0.7361	0.6148	NRAS/PIK3CD/CD48/ITGAL/PTK2B/SH2D1B/KRAS/RAC2/CD244/SOS2/GRB2/PPP3CC/IFNAR1/BID/PTPN6/TNFRSF10A/PRKCA/TNFSF10/PAK1/ICAM2/SH2D1A/KIR3DL2/PPP3CB/CD247/PIK3R2/HRAS/LCK	27
KEGG	hsa04916	Melanogenesis	21/1588	101/8135	0.4121	0.7361	0.6148	TCF7L2/NRAS/ADCY3/PLCB1/PLCB2/WNT5B/CAMK2G/ADCY9/FZD5/CREBBP/KRAS/GNAS/CALM1/CTNNB1/PRKCA/CREB3/EDNRB/WNT10A/MC1R/HRAS/WNT6	21
KEGG	hsa04972	Pancreatic secretion	21/1588	102/8135	0.4316	0.746	0.6231	ADCY3/PLA2G2D/BST1/PLCB1/PLCB2/ADCY9/ATP1B3/ATP2A2/RAB3D/GNAS/CTRB1/CA2/CPB1/ITPR2/PRKCA/ATP1A3/ATP1A1/ATP1B2/CD38/RAB11A/ATP1B1	21
KEGG	hsa05100	Bacterial invasion of epithelial cells	16/1588	77/8135	0.4349	0.746	0.6231	CLTCL1/FN1/ARHGAP10/PIK3CD/ACTR3B/CBL/CTNNA1/ACTG1/ARPC4/ACTB/CTNNB1/DOCK1/PTK2/PXN/PIK3R2/ITGA5	16
KEGG	hsa05218	Melanoma	15/1588	72/8135	0.4356	0.746	0.6231	CDK6/NRAS/PDGFB/PIK3CD/PTEN/RB1/KRAS/CDKN1A/CCND1/E2F2/CDK4/GADD45A/PIK3R2/HRAS/CDKN2A	15
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1588	27/8135	0.4362	0.746	0.6231	FUT7/B3GALNT1/GCNT2/B3GNT2/ST3GAL6/ST3GAL4	6
KEGG	hsa04136	Autophagy - other	7/1588	32/8135	0.4372	0.746	0.6231	IGBP1/ATG9A/ATG2B/GABARAPL1/PPP2CA/GABARAP/ATG2A	7
KEGG	hsa04215	Apoptosis - multiple species	7/1588	32/8135	0.4372	0.746	0.6231	PMAIP1/APAF1/BCL2L1/BID/CASP8/BOK/BCL2	7
KEGG	hsa05143	African trypanosomiasis	8/1588	37/8135	0.4377	0.746	0.6231	F2RL1/HBB/HBA2/PLCB1/PLCB2/THOP1/MYD88/PRKCA	8
KEGG	hsa00620	Pyruvate metabolism	10/1588	47/8135	0.4377	0.746	0.6231	LDHA/ACSS1/ACAT1/LDHB/PDHB/AKR1A1/ACYP2/ME3/GLO1/ME1	10
KEGG	hsa05332	Graft-versus-host disease	9/1588	42/8135	0.4378	0.746	0.6231	HLA-DPA1/HLA-DOA/HLA-DMA/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/HLA-DQB1/KIR3DL2	9
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/1588	143/8135	0.4423	0.7499	0.6263	NRAS/MAPK13/SETDB1/STAT3/PIK3CD/WNT5B/FZD5/PCGF1/KRAS/SMAD3/MAPK14/ID3/GRB2/CTNNB1/JARID2/TCF3/SMAD5/SMAD1/BMI1/NODAL/WNT10A/SMAD2/INHBE/PIK3R2/HRAS/PAX6/MYC/MAPK11/WNT6	29
KEGG	hsa04725	Cholinergic synapse	23/1588	113/8135	0.4487	0.7532	0.6291	GNG10/NRAS/ADCY3/PIK3CD/PLCB1/PLCB2/CAMK2G/ADCY9/KRAS/GNG2/KCNJ14/ITPR2/PRKCA/FOS/CREB3/CACNA1B/GNG11/GNB1/CACNA1D/PIK3R2/BCL2/HRAS/CHRM2	23
KEGG	hsa04931	Insulin resistance	22/1588	108/8135	0.4498	0.7532	0.6291	SREBF1/STAT3/PIK3CD/NR1H3/PRKCQ/PTEN/SLC2A1/PRKAG2/PTPN1/MLXIPL/GFPT1/SLC27A1/PPARGC1A/PRKCD/RPS6KA1/PYGL/PPP1R3D/IRS2/NR1H2/CREB3/PRKAB2/PIK3R2	22
KEGG	hsa04974	Protein digestion and absorption	21/1588	103/8135	0.451	0.7532	0.6291	COL9A2/COL8A2/ATP1B3/SLC16A10/CTRB1/SLC8A1/SLC7A7/KCNE3/KCNN4/CPB1/SLC3A2/COL2A1/COL22A1/ATP1A3/ATP1A1/SLC9A3/ATP1B2/COL4A5/SLC1A5/COL15A1/ATP1B1	21
KEGG	hsa04371	Apelin signaling pathway	28/1588	139/8135	0.4601	0.7619	0.6363	GNG10/NRAS/ADCY3/MRAS/SPP1/PLCB1/PLCB2/MAP1LC3B/ADCY9/PRKAG2/KRAS/SMAD3/RRAS2/SLC8A1/MEF2A/PPARGC1A/CALM1/CCND1/GNG2/ITPR2/TGFBR1/RPS6/PRKAB2/SERPINE1/SMAD2/GNG11/GNB1/HRAS	28
KEGG	hsa00240	Pyrimidine metabolism	12/1588	58/8135	0.4631	0.7619	0.6363	TK2/DCK/CDA/RRM1/NME3/DUT/TK1/TYMS/ENTPD4/DPYD/NUDT2/NME1	12
KEGG	hsa00280	Valine, leucine and isoleucine degradation	10/1588	48/8135	0.4663	0.7619	0.6363	IL4I1/BCAT1/AUH/OXCT2/PCCA/ACAT1/MCEE/ACAD8/MCCC1/HMGCS1	10
KEGG	hsa04724	Glutamatergic synapse	23/1588	114/8135	0.4673	0.7619	0.6363	SLC1A3/GLUL/GNG10/ADCY3/PLCB1/PLCB2/ADCY9/PLA2G4B/GNAS/PPP3CC/GNG2/ITPR2/PRKCA/SHANK3/GRIN3B/DLG4/SLC38A1/PLA2G4E/PPP3CB/GRM6/GNG11/GNB1/CACNA1D	23
KEGG	hsa04940	Type I diabetes mellitus	9/1588	43/8135	0.4681	0.7619	0.6363	HLA-DPA1/HLA-DOA/HLA-DMA/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/HLA-DQB1/ICA1	9
KEGG	hsa04064	NF-kappa B signaling pathway	21/1588	104/8135	0.4705	0.7619	0.6363	PLAU/PRKCQ/BCL2L1/CD40/TRAF2/TNFAIP3/LBP/MYD88/TRAF3/CCL4L1/PTGS2/CSNK2A2/PARP1/MAP3K14/GADD45A/TNFRSF11A/CCL13/EDARADD/BCL2/BTK/LCK	21
KEGG	hsa04934	Cushing syndrome	31/1588	155/8135	0.4722	0.7619	0.6363	TCF7L2/CDK6/ADCY3/PLCB1/PLCB2/AIP/WNT5B/CAMK2G/ADCY9/FZD5/RB1/SP1/GNAS/CDK2/CDKN1A/CCND1/CDKN1B/CTNNB1/E2F2/ITPR2/PDE8B/CDK4/CREB3/WNT10A/CDKN2B/WDR5/CACNA1D/WDR5B/KCNK3/CDKN2A/WNT6	31
KEGG	hsa03430	Mismatch repair	5/1588	23/8135	0.476	0.7628	0.6371	PMS2/POLD1/MLH1/LIG1/RPA4	5
KEGG	hsa00061	Fatty acid biosynthesis	4/1588	18/8135	0.4783	0.7628	0.6371	ACSL3/FASN/ACSL5/CBR4	4
KEGG	hsa03018	RNA degradation	16/1588	79/8135	0.4796	0.7628	0.6371	ENO1/DIS3L/PFKP/PAN2/PFKM/BTG3/ENO2/PABPC1/SKIV2L/NUDT16/EXOSC1/CNOT4/EXOSC5/ENO3/DCP2/CNOT8	16
KEGG	hsa04920	Adipocytokine signaling pathway	14/1588	69/8135	0.484	0.7661	0.6398	ACSL3/STAT3/PRKCQ/LEP/SLC2A1/PRKAG2/TRAF2/PPARGC1A/RXRA/NFKBIE/ACSL5/IRS2/STK11/PRKAB2	14
KEGG	hsa04330	Notch signaling pathway	12/1588	59/8135	0.4889	0.7703	0.6433	RBPJ/DTX1/RBPJL/CREBBP/KAT2A/TLE4/NOTCH2/NOTCH4/SNW1/MFNG/DTX3L/DLL1	12
KEGG	hsa04360	Axon guidance	36/1588	182/8135	0.4947	0.7734	0.6459	NRP1/NRAS/UNC5B/EPHB4/PLXNA3/PIK3CD/FES/NTNG2/PLXNA1/WNT5B/CAMK2G/CFL2/KRAS/RAC2/SRGAP1/SEMA4A/RGMA/L1CAM/PPP3CC/NCK1/LIMK2/PRKCA/SSH2/PAK1/LRIG2/PTK2/SSH1/EPHB6/PAK2/RASA1/PPP3CB/SEMA4B/NFATC3/PIK3R2/HRAS/CXCR4	36
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/1588	223/8135	0.4955	0.7734	0.6459	MGST1/VDAC1/NRAS/MAPK13/ABL2/EPHX1/MAP2K7/PIK3CD/UQCRB/PTEN/CAT/GSTO1/GSTM1/KRAS/GSTM4/SOS2/SLC26A6/NDUFV3/MAPK14/PTPN1/NQO1/NFE2L2/NCF1/SDHD/GSTM2/GRB2/PRKCD/UQCRC1/NDUFB1/PRKD3/GSTM5/PTK2/CYP1B1/FOS/MAP3K14/AKR1A1/PRKD2/SLC25A4/NDUFA10/NDUFA4L2/PIK3R2/HRAS/ACP1/MAPK11	44
KEGG	hsa04730	Long-term depression	12/1588	60/8135	0.5145	0.7992	0.6675	NRAS/GNA12/PLCB1/PLCB2/PLA2G4B/KRAS/GNAS/PPP2CA/ITPR2/PRKCA/PLA2G4E/HRAS	12
KEGG	hsa05012	Parkinson disease	52/1588	266/8135	0.5207	0.8045	0.6719	VDAC1/SLC11A2/SLC39A8/APAF1/TUBA1B/LRRK2/PSMD14/BCL2L1/HSPA5/UQCRB/TUBA1C/TUBB6/CAMK2G/TUBB/PSMC2/TUBA4A/TUBA1A/PSMD12/TUBB3/TUBB2A/GNAS/NDUFV3/SLC39A1/PSMA6/NFE2L2/SDHD/PSMC1/KLC1/UBE2J1/DUSP1/CALM1/PSMD3/PSMC3/UBA7/UQCRC1/ITPR2/PSMD7/NDUFB1/SLC39A10/UCHL1/PSMD1/PINK1/PSMD2/SLC25A4/NDUFA10/PSMD8/NDUFA4L2/ERN1/ATF6/PSMD4/PSMD9/KIF5B	52
KEGG	hsa05145	Toxoplasmosis	22/1588	112/8135	0.5253	0.8045	0.6719	HSPA1L/MAPK13/HLA-DPA1/STAT3/CIITA/BCL2L1/HLA-DOA/HLA-DMA/MAP2K6/CD40/HLA-DRA/MAP2K3/HLA-DQA1/MAPK14/HLA-DPB1/CASP8/MYD88/HLA-DQB1/SOCS1/IL10RA/BCL2/MAPK11	22
KEGG	hsa05133	Pertussis	15/1588	76/8135	0.5273	0.8045	0.6719	MAPK13/C1QC/C1QB/CASP1/CFL2/MAPK14/IRF3/CALM1/C1R/C1QA/C5/MYD88/FOS/MAPK11/ITGA5	15
KEGG	hsa04151	PI3K-Akt signaling pathway	69/1588	354/8135	0.5279	0.8045	0.6719	COL9A2/GNG10/LPAR5/CDK6/NRAS/YWHAH/FN1/ITGB5/PDGFB/SPP1/ITGAV/PIK3CD/PPP2R5B/IL2RG/BCL2L1/PPP2R3A/IL7R/PTEN/HSP90B1/RHEB/VEGFB/MYB/PPP2R5A/TCL1A/KRAS/YWHAQ/CSF1R/CDK2/SOS2/CDKN1A/CSF3R/THEM4/GRB2/IFNAR1/RXRA/PPP2CA/CCND1/CDKN1B/GNG2/COL2A1/ITGA3/EIF4B/MCL1/YWHAG/PRKCA/IL2RB/CCND2/TCL1B/TSC2/PTK2/ANGPT1/CDK4/CSH2/CREB3/RPS6/STK11/COL4A5/EIF4EBP1/GNG11/DDIT4/GNB1/PIK3R2/BCL2/EPOR/HRAS/CHRM2/MYC/THBS1/ITGA5	69
KEGG	hsa05146	Amoebiasis	20/1588	102/8135	0.5312	0.8045	0.6719	CD1D/FN1/SERPINB10/PIK3CD/PLCB1/PLCB2/RAB7B/RAB5A/PRDX1/C8G/GNAS/GNA15/ACTN1/PRKCA/IL1R2/HSPB1/PTK2/COL4A5/CD1E/PIK3R2	20
KEGG	hsa00260	Glycine, serine and threonine metabolism	8/1588	40/8135	0.5328	0.8045	0.6719	SDS/SDSL/CBS/GNMT/SRR/GATM/AMT/SHMT2	8
KEGG	hsa00230	Purine metabolism	25/1588	128/8135	0.5347	0.8045	0.6719	PAICS/ADCY3/HPRT1/PDE6G/PAPSS2/ATIC/ENPP4/ADCY9/DCK/ADA/PRPS1/RRM1/PRPS2/NME3/GMPR2/GART/NUDT16/ENTPD4/PDE8B/NUDT2/NUDT9/NME1/PPAT/PDE4D/ADK	25
KEGG	hsa00561	Glycerolipid metabolism	12/1588	61/8135	0.5396	0.8057	0.6729	PNPLA2/MBOAT1/GLA/GK/AGK/DGAT1/DGAT2/MGLL/LPIN3/AKR1A1/AGPAT2/LPIN2	12
KEGG	hsa05131	Shigellosis	48/1588	247/8135	0.5403	0.8057	0.6729	VDAC1/RRAGD/MAPK13/RRAGC/PIK3CD/PLCB1/PRKCQ/BCL2L1/PLCB2/RBCK1/MAP1LC3B/CASP1/ACTR3B/TIFA/PLCD1/ACTG1/CASP4/ARHGEF2/RNF31/MAPK14/TRAF2/IRF3/ARPC4/BNIP3/ACTB/CCL5/ACTN1/CALCOCO2/NAIP/PRKCD/FOXO4/MYD88/DOCK1/ITPR2/NLRC4/PTK2/UBE2V1/CYTH1/TLN2/PXN/GSK3A/HK3/BTRC/PIK3R2/BCL2/CD44/MAPK11/ITGA5	48
KEGG	hsa03013	Nucleocytoplasmic transport	21/1588	108/8135	0.5471	0.8121	0.6782	NUP214/SUMO3/NUP210/SEH1L/PNN/NUP205/CSE1L/IPO11/SUMO2/RAN/SNUPN/NCBP1/KPNA4/KPNA6/KPNA3/THOC5/XPO1/NUP43/NUP62/NUP107/TNPO3	21
KEGG	hsa04611	Platelet activation	24/1588	124/8135	0.5552	0.8189	0.6839	ADCY3/MAPK13/RASGRP2/PIK3CD/PLCB1/PLCB2/ARHGEF1/ADCY9/PLA2G4B/ACTG1/STIM1/GNAS/MAPK14/SNAP23/GP9/ACTB/TBXAS1/ITPR2/GP6/TLN2/PLA2G4E/PIK3R2/BTK/MAPK11	24
KEGG	hsa04970	Salivary secretion	18/1588	93/8135	0.5582	0.8189	0.6839	ADCY3/CAMP/BST1/PLCB1/PLCB2/ADCY9/ATP1B3/GNAS/VAMP2/KCNN4/CALM1/ITPR2/PRKCA/ATP1A3/ATP1A1/ATP1B2/CD38/ATP1B1	18
KEGG	hsa04720	Long-term potentiation	13/1588	67/8135	0.559	0.8189	0.6839	NRAS/PLCB1/PLCB2/CAMK2G/CREBBP/KRAS/PPP3CC/CALM1/RPS6KA1/ITPR2/PRKCA/PPP3CB/HRAS	13
KEGG	hsa00100	Steroid biosynthesis	4/1588	20/8135	0.5676	0.8278	0.6914	SQLE/DHCR7/DHCR24/SOAT1	4
KEGG	hsa00600	Sphingolipid metabolism	10/1588	52/8135	0.5769	0.8368	0.6989	UGCG/GBA/SGPL1/GLA/HEXB/GBA2/DEGS1/SMPD4/SPTLC2/NEU1	10
KEGG	hsa00052	Galactose metabolism	6/1588	31/8135	0.5813	0.8368	0.6989	GALM/PFKP/GLA/PFKM/GALT/HK3	6
KEGG	hsa00410	beta-Alanine metabolism	6/1588	31/8135	0.5813	0.8368	0.6989	CSAD/SMOX/MLYCD/CNDP2/ALDH3B1/DPYD	6
KEGG	hsa04144	Endocytosis	48/1588	251/8135	0.5899	0.8457	0.7063	AGAP3/CLTCL1/DAB2/HSPA1L/EHD4/SNX1/IL2RG/FOLR3/CHMP1B/RAB5A/SNX5/TFRC/ACTR3B/LDLRAP1/RAB11FIP4/CBL/ARRB2/RAB11FIP1/VPS36/VPS26B/SMAD3/VPS37C/SH3GLB1/VPS26A/BIN1/ARF4/ARPC4/VPS35/RAB31/PSD4/CBLB/TGFBR1/RAB11FIP5/IL2RB/CHMP2B/CYTH1/TSG101/ZFYVE16/SMAD2/SH3GLB2/EEA1/WIPF2/GRK6/VPS45/HRAS/RAB11A/KIF5B/CXCR4	48
KEGG	hsa00380	Tryptophan metabolism	8/1588	42/8135	0.5928	0.8461	0.7067	IL4I1/CAT/ACAT1/TPH1/AFMID/CYP1B1/KYNU/GCDH	8
KEGG	hsa05410	Hypertrophic cardiomyopathy	17/1588	90/8135	0.6028	0.8568	0.7156	ITGB5/TPM4/ITGAV/CACNA2D3/LMNA/PRKAG2/ATP2A2/ACTG1/SLC8A1/SGCA/ACTB/ITGA3/CACNG5/PRKAB2/TPM1/CACNA1D/ITGA5	17
KEGG	hsa04072	Phospholipase D signaling pathway	28/1588	148/8135	0.6072	0.8593	0.7176	LPAR5/NRAS/RALGDS/ADCY3/MRAS/PDGFB/GNA12/PIK3CD/PLCB1/PLCB2/ADCY9/RHEB/PLA2G4B/PTK2B/RALA/KRAS/RRAS2/GNAS/SOS2/GRB2/PRKCA/TSC2/CYTH1/AGPAT2/PLA2G4E/GRM6/PIK3R2/HRAS	28
KEGG	hsa00640	Propanoate metabolism	6/1588	32/8135	0.6145	0.8658	0.7231	LDHA/ACSS1/PCCA/MLYCD/LDHB/MCEE	6
KEGG	hsa05414	Dilated cardiomyopathy	18/1588	96/8135	0.6169	0.8658	0.7231	ADCY3/ITGB5/TPM4/ITGAV/CACNA2D3/ADCY9/LMNA/ATP2A2/ACTG1/GNAS/SLC8A1/SGCA/ACTB/ITGA3/CACNG5/TPM1/CACNA1D/ITGA5	18
KEGG	hsa03320	PPAR signaling pathway	14/1588	75/8135	0.6206	0.8665	0.7237	OLR1/SCD/ACSL3/NR1H3/PLTP/GK/PPARD/SLC27A1/RXRA/ACSL5/HMGCS1/ME3/PPARG/ME1	14
KEGG	hsa05010	Alzheimer disease	73/1588	384/8135	0.623	0.8665	0.7237	VDAC1/NRAS/SLC11A2/FRAT1/MAP2K7/SLC39A8/PIK3CD/RTN3/APAF1/TUBA1B/PLCB1/PSMD14/PLCB2/UQCRB/TUBA1C/APOE/TUBB6/WNT5B/TUBB/PSMC2/FZD5/TUBA4A/TUBA1A/ATP2A2/KRAS/PSMD12/TUBB3/TUBB2A/NDUFV3/LRP6/TRAF2/ATG2B/SLC39A1/PSMA6/FRAT2/SDHD/PSMC1/PPP3CC/KLC1/CALM1/PSMD3/PSMC3/BID/AGER/CASP8/UQCRC1/CTNNB1/ITPR2/PSMD7/NDUFB1/CSNK1E/SLC39A10/PTGS2/CSNK2A2/IRS2/PSMD1/PSMD2/SLC25A4/NDUFA10/WNT10A/PSMD8/PPP3CB/NDUFA4L2/ERN1/CACNA1D/PIK3R2/ATF6/HRAS/ATG2A/PSMD4/PSMD9/KIF5B/WNT6	73
KEGG	hsa03460	Fanconi anemia pathway	10/1588	54/8135	0.6282	0.8665	0.7237	PMS2/EME2/MLH1/TOP3A/WDR48/FANCG/RPA4/TOP3B/BRIP1/ERCC4	10
KEGG	hsa00062	Fatty acid elongation	5/1588	27/8135	0.629	0.8665	0.7237	ELOVL3/ACOT4/THEM4/PPT2/ELOVL1	5
KEGG	hsa00430	Taurine and hypotaurine metabolism	3/1588	16/8135	0.6304	0.8665	0.7237	FMO5/CSAD/FMO2	3
KEGG	hsa00565	Ether lipid metabolism	9/1588	49/8135	0.6378	0.8731	0.7292	ENPP2/PLA2G2D/PLA2G4B/CHPT1/PLA2G6/PLD4/GDPD3/PLA2G4E/AGPS	9
KEGG	hsa05415	Diabetic cardiomyopathy	38/1588	203/8135	0.6429	0.8765	0.732	VDAC1/MAPK13/PIK3CD/PLCB1/PLCB2/UQCRB/PDK4/CAMK2G/PTEN/SP1/SLC2A1/ATP2A2/RAC2/SMAD3/NDUFV3/MAPK14/GFPT1/NCF1/SDHD/PRKCD/AGER/NCF4/UQCRC1/TGFBR1/PRKCA/NDUFB1/PARP1/GSR/PDHB/CTSD/MMP9/SLC25A4/NDUFA10/SMAD2/NDUFA4L2/PIK3R2/MMP2/MAPK11	38
KEGG	hsa00590	Arachidonic acid metabolism	11/1588	61/8135	0.6662	0.9014	0.7528	PLA2G2D/PLA2G4B/GPX3/PTGES2/PLA2G6/PTGES3/LTC4S/TBXAS1/CBR3/PTGS2/PLA2G4E	11
KEGG	hsa04512	ECM-receptor interaction	16/1588	88/8135	0.667	0.9014	0.7528	COL9A2/FN1/ITGB5/CD47/SPP1/ITGAV/SDC4/GP9/COL2A1/ITGA3/GP6/COL4A5/SV2A/THBS1/CD44/ITGA5	16
KEGG	hsa00120	Primary bile acid biosynthesis	3/1588	17/8135	0.6731	0.9014	0.7528	HSD3B7/ACOT8/CH25H	3
KEGG	hsa00450	Selenocompound metabolism	3/1588	17/8135	0.6731	0.9014	0.7528	PAPSS2/TXNRD2/SCLY	3
KEGG	hsa04923	Regulation of lipolysis in adipocytes	10/1588	56/8135	0.6762	0.9014	0.7528	ADCY3/PNPLA2/PIK3CD/ADCY9/GNAS/ABHD5/MGLL/PTGS2/IRS2/PIK3R2	10
KEGG	hsa04657	IL-17 signaling pathway	17/1588	94/8135	0.6785	0.9014	0.7528	MAPK13/MAPK6/HSP90B1/CCL2/MAPK14/TRAF2/TNFAIP3/CASP8/TRAF3/IKBKE/PTGS2/IL17RA/FOS/ELAVL1/MMP9/S100A9/MAPK11	17
KEGG	hsa04510	Focal adhesion	37/1588	201/8135	0.6843	0.9014	0.7528	COL9A2/PARVG/FN1/ITGB5/PDGFB/SPP1/ITGAV/PIK3CD/PTEN/VEGFB/ACTG1/RAC2/PPP1R12B/SOS2/GRB2/ACTB/ACTN1/CCND1/CTNNB1/DOCK1/COL2A1/ITGA3/PRKCA/CCND2/PAK1/PTK2/PARVB/RAPGEF1/TLN2/PXN/PAK2/COL4A5/PIK3R2/BCL2/HRAS/THBS1/ITGA5	37
KEGG	hsa04727	GABAergic synapse	16/1588	89/8135	0.6855	0.9014	0.7528	GLUL/GNG10/ADCY3/SLC6A13/GABBR1/ADCY9/GABARAPL1/GNG2/PRKCA/GABARAP/CACNA1B/SLC38A1/SLC38A5/GNG11/GNB1/CACNA1D	16
KEGG	hsa04976	Bile secretion	16/1588	89/8135	0.6855	0.9014	0.7528	ADCY3/EPHX1/ADCY9/ATP1B3/SLC2A1/GNAS/ABCC3/CA2/RXRA/ATP1A3/ATP1A1/SLC9A3/ATP1B2/AQP9/HMGCR/ATP1B1	16
KEGG	hsa04217	Necroptosis	29/1588	159/8135	0.6907	0.9026	0.7538	GLUL/VDAC1/STAT3/MLKL/RBCK1/USP21/CAMK2G/CHMP1B/CASP1/PLA2G4B/RNF31/TRAF2/TNFAIP3/STAT5A/IFNAR1/STAT4/BID/CASP8/TNFRSF10A/SPATA2L/TNFSF10/PYGL/CHMP2B/PARP1/STAT5B/SLC25A4/PLA2G4E/STAT6/BCL2	29
KEGG	hsa04744	Phototransduction	5/1588	29/8135	0.6945	0.9026	0.7538	PDE6G/GUCA1B/CALM1/SAG/GNB1	5
KEGG	hsa01212	Fatty acid metabolism	10/1588	57/8135	0.6987	0.9026	0.7538	SCD/ACSL3/ELOVL3/FASN/ACAT1/ACSL5/ACADVL/PPT2/CBR4/ELOVL1	10
KEGG	hsa05134	Legionellosis	10/1588	57/8135	0.6987	0.9026	0.7538	HSPA1L/APAF1/RAB1A/CASP1/BNIP3/NAIP/CASP8/VCP/MYD88/NLRC4	10
KEGG	hsa04930	Type II diabetes mellitus	8/1588	46/8135	0.6999	0.9026	0.7538	PIK3CD/PRKCD/SOCS1/IRS2/CACNA1B/HK3/CACNA1D/PIK3R2	8
KEGG	hsa00310	Lysine degradation	11/1588	63/8135	0.7093	0.91	0.76	SETDB1/PLOD3/EHMT2/NSD1/ACAT1/PRDM7/SETD2/EZH1/PRDM9/PRDM2/GCDH	11
KEGG	hsa01232	Nucleotide metabolism	15/1588	85/8135	0.7111	0.91	0.76	HPRT1/TK2/DCK/CDA/ADA/RRM1/NME3/GMPR2/DUT/TK1/TYMS/NUDT16/ENTPD4/NME1/ADK	15
KEGG	hsa03440	Homologous recombination	7/1588	41/8135	0.7144	0.9107	0.7606	POLD1/BARD1/TOP3A/XRCC2/RPA4/TOP3B/BRIP1	7
KEGG	hsa04914	Progesterone-mediated oocyte maturation	18/1588	102/8135	0.7223	0.916	0.765	ADCY3/MAPK13/PIK3CD/PLK1/ADCY9/KRAS/CDK2/MAPK14/SPDYC/CDC25B/RPS6KA1/CCNB2/CPEB4/MOS/CCNA2/AURKA/PIK3R2/MAPK11	18
KEGG	hsa00020	Citrate cycle (TCA cycle)	5/1588	30/8135	0.724	0.916	0.765	IDH2/SDHD/PDHB/IDH3A/IDH3B	5
KEGG	hsa00512	Mucin type O-glycan biosynthesis	6/1588	36/8135	0.7313	0.916	0.765	GALNT14/ST3GAL2/GALNT11/ST6GALNAC2/ST3GAL1/ST6GALNAC4	6
KEGG	hsa05320	Autoimmune thyroid disease	9/1588	53/8135	0.7324	0.916	0.765	HLA-DPA1/HLA-DOA/HLA-DMA/CD40/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/HLA-DQB1	9
KEGG	hsa04014	Ras signaling pathway	42/1588	232/8135	0.7346	0.916	0.765	GNG10/NRAS/RALGDS/MRAS/RGL1/ABL2/PDGFB/RASGRP2/PIK3CD/PLA2G2D/BCL2L1/RASGRP3/RAB5A/RIN1/VEGFB/RASGRP4/PLA2G4B/RALA/KRAS/RAC2/CSF1R/RRAS2/SOS2/PLA2G6/GRB2/CALM1/TIAM1/GNG2/FOXO4/PRKCA/PAK1/RGL2/ANGPT1/PAK2/PLA2G4E/RASA1/NF1/GNG11/GNB1/PIK3R2/HRAS/ETS1	42
KEGG	hsa04390	Hippo signaling pathway	28/1588	157/8135	0.735	0.916	0.765	TCF7L2/YWHAH/WNT5B/FZD5/CTNNA1/ACTG1/YWHAQ/SMAD3/TEAD2/SMAD7/ACTB/PPP2CA/CCND1/CTNNB1/TGFBR1/YWHAG/CCND2/CSNK1E/DLG4/CSNK1D/SMAD1/BMP2/SERPINE1/WNT10A/SMAD2/BTRC/MYC/WNT6	28
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/1588	25/8135	0.748	0.9261	0.7735	PLA2G2D/PLA2G4B/PLA2G6/PLA2G4E	4
KEGG	hsa04927	Cortisol synthesis and secretion	11/1588	65/8135	0.7486	0.9261	0.7735	ADCY3/PLCB1/PLCB2/ADCY9/SP1/GNAS/ITPR2/PDE8B/CREB3/CACNA1D/KCNK3	11
KEGG	hsa04726	Serotonergic synapse	20/1588	115/8135	0.7538	0.9286	0.7755	GNG10/NRAS/PLCB1/PLCB2/PLA2G4B/KRAS/GNAS/DUSP1/GNG2/ITPR2/PRKCA/TPH1/PTGS2/CACNA1B/PLA2G4E/GNG11/KCNJ5/GNB1/CACNA1D/HRAS	20
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/1588	37/8135	0.7562	0.9286	0.7755	IL4I1/GLUL/ASRGL1/GOT1/GFPT1/PPAT	6
KEGG	hsa04975	Fat digestion and absorption	7/1588	43/8135	0.7616	0.9317	0.7782	ABCA1/PLA2G2D/DGAT1/SLC27A1/DGAT2/ACAT1/AGPAT2	7
KEGG	hsa00982	Drug metabolism - cytochrome P450	12/1588	72/8135	0.7734	0.9428	0.7874	MGST1/FMO5/GSTO1/FMO2/GSTM1/GSTM4/GSTM2/CYP2A7/GSTP1/GSTM5/ALDH3B1/GSTK1	12
KEGG	hsa04932	Non-alcoholic fatty liver disease	27/1588	155/8135	0.7765	0.9431	0.7876	SREBF1/MAPK13/PIK3CD/NR1H3/UQCRB/LEP/PRKAG2/NDUFV3/MAPK14/TRAF2/MLXIPL/SDHD/RXRA/BID/CASP8/UQCRC1/NDUFB1/IRS2/FOS/GSK3A/PRKAB2/NDUFA10/NDUFA4L2/ERN1/PIK3R2/PPARG/MAPK11	27
KEGG	hsa04714	Thermogenesis	41/1588	232/8135	0.7878	0.9465	0.7905	NRAS/ADCY3/MAPK13/ACSL3/PNPLA2/SLC25A20/UQCRB/SMARCD3/ADCY9/RHEB/SMARCC2/PRKAG2/ACTG1/KRAS/MAP2K3/GNAS/SOS2/NDUFV3/MAPK14/COX19/SDHD/GRB2/ACTB/PPARGC1A/RPS6KA1/SLC25A29/UQCRC1/MGLL/NDUFB1/TSC2/ACSL5/CREB3/RPS6/PRKAB2/DPF1/NDUFA10/NDUFA4L2/COX15/HRAS/PPARG/MAPK11	41
KEGG	hsa04340	Hedgehog signaling pathway	9/1588	56/8135	0.7914	0.9465	0.7905	ARRB2/CCND1/CCND2/CSNK1E/GLI3/CSNK1D/BTRC/HHATL/BCL2	9
KEGG	hsa04613	Neutrophil extracellular trap formation	33/1588	190/8135	0.801	0.9465	0.7905	FPR3/VDAC1/AZU1/MAPK13/CAMP/PIK3CD/HDAC8/PLCB1/PLCB2/HDAC10/ITGAL/CASP1/HDAC9/ACTG1/RAC2/PADI4/FCGR1A/CASP4/MAPK14/NCF1/ACTB/AGER/NCF4/C5/FPR1/PRKCA/CLEC7A/MPO/CLCN5/AQP9/SLC25A4/PIK3R2/MAPK11	33
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/1588	27/8135	0.8017	0.9465	0.7905	SCD/ELOVL3/ACOT4/ELOVL1	4
KEGG	hsa04966	Collecting duct acid secretion	4/1588	27/8135	0.8017	0.9465	0.7905	ATP6V1E2/ATP6V0A1/CA2/ATP6V0D1	4
KEGG	hsa05032	Morphine addiction	15/1588	91/8135	0.8056	0.9465	0.7905	GNG10/ADCY3/GABBR1/ADCY9/ARRB2/GNAS/GNG2/PRKCA/PDE8B/CACNA1B/GNG11/GRK6/KCNJ5/GNB1/PDE4D	15
KEGG	hsa04913	Ovarian steroidogenesis	8/1588	51/8135	0.8056	0.9465	0.7905	ADCY3/ADCY9/PLA2G4B/GNAS/ACOT4/PTGS2/CYP1B1/PLA2G4E	8
KEGG	hsa04530	Tight junction	29/1588	169/8135	0.8096	0.9465	0.7905	CD1D/MAP2K7/TUBA1B/TUBA1C/RAPGEF6/TUBA4A/ACTR3B/TUBA1A/PRKAG2/ARHGEF18/ACTG1/ARHGEF2/CLDN17/ARPC4/SLC9A3R1/ACTB/PPP2CA/ACTN1/TIAM1/CCND1/TJP2/CDK4/STK11/PRKAB2/CRB3/CD1E/CACNA1D/CLDN9/ARHGAP17	29
KEGG	hsa04713	Circadian entrainment	16/1588	97/8135	0.8105	0.9465	0.7905	GNG10/ADCY3/PLCB1/PLCB2/CAMK2G/ADCY9/GNAS/CALM1/GNG2/PRKCA/FOS/GNG11/KCNJ5/ADCYAP1/GNB1/CACNA1D	16
KEGG	hsa04020	Calcium signaling pathway	42/1588	240/8135	0.8108	0.9465	0.7905	VDAC1/ADCY3/PDGFB/P2RX7/ITPKA/LTB4R2/PLCB1/PLCB2/MCOLN2/CAMK2G/PHKA2/ADCY9/VEGFB/PLCD1/PTK2B/ATP2A2/P2RX4/STIM1/GNAS/GNA15/PHKG2/SLC8A1/PPP3CC/TACR2/CALM1/CASQ1/ADORA2B/ITPR2/TNNC2/PRKCA/CYSLTR1/MCOLN1/CACNA1B/EDNRB/CAMK1D/SLC25A4/PPP3CB/CD38/CACNA1D/CHRM2/ITPKB/CXCR4	42
KEGG	hsa05217	Basal cell carcinoma	10/1588	63/8135	0.8124	0.9465	0.7905	TCF7L2/WNT5B/FZD5/CDKN1A/CTNNB1/GLI3/GADD45A/BMP2/WNT10A/WNT6	10
KEGG	hsa04924	Renin secretion	11/1588	69/8135	0.8161	0.9465	0.7905	CTSB/PLCB1/PLCB2/GNAS/PPP3CC/CALM1/ITPR2/PTGER2/PPP3CB/ADCYAP1/CACNA1D	11
KEGG	hsa05031	Amphetamine addiction	11/1588	69/8135	0.8161	0.9465	0.7905	CAMK2G/GNAS/PPP3CC/CALM1/SIRT1/PRKCA/GRIN3B/FOS/CREB3/PPP3CB/CACNA1D	11
KEGG	hsa04260	Cardiac muscle contraction	14/1588	87/8135	0.8277	0.9557	0.7982	TPM4/UQCRB/CACNA2D3/ATP1B3/ATP2A2/SLC8A1/UQCRC1/CACNG5/ATP1A3/ATP1A1/ATP1B2/TPM1/CACNA1D/ATP1B1	14
KEGG	hsa04622	RIG-I-like receptor signaling pathway	11/1588	70/8135	0.8307	0.9557	0.7982	MAPK13/NLRX1/MAPK14/TRAF2/IRF3/CASP8/CASP10/TRAF3/IKBKE/RNF125/MAPK11	11
KEGG	hsa00340	Histidine metabolism	3/1588	22/8135	0.8327	0.9557	0.7982	HAL/CNDP2/ALDH3B1	3
KEGG	hsa04022	cGMP-PKG signaling pathway	28/1588	167/8135	0.843	0.9594	0.8013	VDAC1/ADCY3/GNA12/PLCB1/PLCB2/ADCY9/RGS2/ATP1B3/KCNJ8/ATP2A2/SLC8A1/MEF2A/PPP3CC/CALM1/ITPR2/GTF2IRD1/ATP1A3/ATP1A1/IRS2/ATP1B2/CREB3/EDNRB/SLC25A4/PPP3CB/NFATC3/KCNMB1/CACNA1D/ATP1B1	28
KEGG	hsa00591	Linoleic acid metabolism	4/1588	29/8135	0.8458	0.9594	0.8013	PLA2G2D/PLA2G4B/PLA2G6/PLA2G4E	4
KEGG	hsa04392	Hippo signaling pathway - multiple species	4/1588	29/8135	0.8458	0.9594	0.8013	RASSF2/TEAD2/CSNK1E/PAK1	4
KEGG	hsa04270	Vascular smooth muscle contraction	22/1588	134/8135	0.8474	0.9594	0.8013	ADCY3/GNA12/PLA2G2D/PLCB1/PRKCQ/PLCB2/ARHGEF1/ADM/ADCY9/PLA2G4B/PRKCH/PPP1R12B/GNAS/PLA2G6/CALM1/PRKCD/ADORA2B/ITPR2/PRKCA/PLA2G4E/KCNMB1/CACNA1D	22
KEGG	hsa04060	Cytokine-cytokine receptor interaction	51/1588	295/8135	0.856	0.9657	0.8065	CXCL9/TNFRSF21/IL2RG/LEP/IL11RA/IL7R/IL16/CD40/CXCL16/CSF1R/CCL2/TNFRSF10C/TNFRSF8/CSF3R/CXCR3/IL32/IFNAR1/TNFRSF4/CCL5/CCR10/EBI3/TGFBR1/TNFRSF6B/CD27/TNFRSF10A/CCL4L1/TNFSF10/IL2RB/IL18RAP/CCL18/IL1R2/TNFRSF25/IL17RA/IL18R1/CSH2/IL22RA1/NODAL/BMP2/TNFRSF11A/CCL13/CCL1/IL15/CXCR6/CXCL13/INHBE/CTF1/IL10RA/IL20RB/EPOR/CCR3/CXCR4	51
KEGG	hsa00350	Tyrosine metabolism	5/1588	36/8135	0.8587	0.9657	0.8065	IL4I1/GOT1/MIF/ALDH3B1/GSTZ1	5
KEGG	hsa00910	Nitrogen metabolism	2/1588	17/8135	0.8726	0.9771	0.816	GLUL/CA2	2
KEGG	hsa04977	Vitamin digestion and absorption	3/1588	24/8135	0.8747	0.9771	0.816	TCN2/RBP2/SLC19A1	3
KEGG	hsa00830	Retinol metabolism	10/1588	68/8135	0.8797	0.9794	0.8179	DHRS3/RDH5/ALDH1A1/DGAT1/CYP2S1/CYP2A7/ALDH1A2/DHRS4L2/DHRS4/RDH11	10
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1588	70/8135	0.9004	0.9953	0.8312	MAPK13/ATP6V1E2/ATP6V0A1/MAPK14/CCL5/PAK1/MAP3K14/ATP6V0D1/ATP6AP1/MAPK11	10
KEGG	hsa03040	Spliceosome	23/1588	147/8135	0.9062	0.9953	0.8312	HSPA1L/SMNDC1/SYF2/PPIL1/HNRNPU/RBM17/TXNL4A/SF3A2/PQBP1/NCBP1/HNRNPA3/SNW1/RBMX/PUF60/CDC5L/CHERP/DDX42/SF3A1/PRPF38A/SNRPD3/RP9/PRPF38B/PRPF18	23
KEGG	hsa04950	Maturity onset diabetes of the young	3/1588	26/8135	0.9071	0.9953	0.8312	HHEX/NEUROD1/PAX6	3
KEGG	hsa04723	Retrograde endocannabinoid signaling	23/1588	148/8135	0.9125	0.9953	0.8312	GNG10/ADCY3/MAPK13/FAAH/PLCB1/PLCB2/ADCY9/NDUFV3/MAPK14/GNG2/ITPR2/MGLL/PRKCA/NDUFB1/PTGS2/CACNA1B/NDUFA10/NDUFA4L2/GNG11/KCNJ5/GNB1/CACNA1D/MAPK11	23
KEGG	hsa04721	Synaptic vesicle cycle	11/1588	78/8135	0.9172	0.9953	0.8312	SLC1A3/CLTCL1/SLC6A13/ATP6V1E2/SNAP25/ATP6V0A1/VAMP2/RAB3A/ATP6V0D1/CACNA1B/UNC13B	11
KEGG	hsa00514	Other types of O-glycan biosynthesis	6/1588	47/8135	0.9189	0.9953	0.8312	POFUT1/PLOD3/ST6GAL1/GALNT14/GALNT11/MFNG	6
KEGG	hsa03420	Nucleotide excision repair	6/1588	47/8135	0.9189	0.9953	0.8312	ERCC5/POLD1/LIG1/ERCC3/RPA4/ERCC4	6
KEGG	hsa00040	Pentose and glucuronate interconversions	4/1588	34/8135	0.9211	0.9953	0.8312	GUSB/DHDH/KL/AKR1A1	4
KEGG	hsa03020	RNA polymerase	4/1588	34/8135	0.9211	0.9953	0.8312	POLR1D/POLR2D/POLR3A/POLR2H	4
KEGG	hsa03015	mRNA surveillance pathway	14/1588	97/8135	0.9237	0.9953	0.8312	PPP2R5B/PPP2R3A/GSPT1/PPP2R5A/WDR33/PNN/PABPC1/PABPN1/PPP2CA/NCBP1/TARDBP/CSTF2/CPSF2/PAPOLG	14
KEGG	hsa05206	MicroRNAs in cancer	51/1588	310/8135	0.9306	0.9974	0.833	PIM1/PLAU/CDK6/NRAS/KIF23/PDGFB/SLC45A3/STAT3/PIK3CD/PTEN/CREBBP/KRAS/ST14/CDCA5/SOX4/NOTCH2/SOS2/CDKN1A/DNMT1/SLC7A1/GRB2/CDC25B/CCND1/CDKN1B/E2F2/FSCN1/NOTCH4/MCL1/SIRT1/PRKCA/IGF2BP1/CCND2/PDCD4/PTGS2/SOCS1/CYP1B1/DNMT3A/IRS2/BMI1/TPM1/MMP9/BCL2L2/DDIT4/PIK3R2/BCL2/HRAS/MYC/THBS1/CDKN2A/CD44/ITGA5	51
KEGG	hsa00650	Butanoate metabolism	3/1588	28/8135	0.9317	0.9974	0.833	OXCT2/ACAT1/HMGCS1	3
KEGG	hsa00500	Starch and sucrose metabolism	4/1588	36/8135	0.9406	0.9975	0.8331	GPI/PYGL/PGM2L1/HK3	4
KEGG	hsa00071	Fatty acid degradation	5/1588	43/8135	0.9417	0.9975	0.8331	ACSL3/ACAT1/ACSL5/ACADVL/GCDH	5
KEGG	hsa00860	Porphyrin metabolism	5/1588	43/8135	0.9417	0.9975	0.8331	GUSB/PPOX/FXN/CP/COX15	5
KEGG	hsa04623	Cytosolic DNA-sensing pathway	8/1588	63/8135	0.9437	0.9975	0.8331	POLR1D/CASP1/IRF3/CCL5/CCL4L1/IKBKE/POLR3A/POLR2H	8
KEGG	hsa00220	Arginine biosynthesis	2/1588	22/8135	0.9469	0.9975	0.8331	GLUL/GOT1	2
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/1588	30/8135	0.9501	0.9975	0.8331	GUSB/KL/AKR1A1	3
KEGG	hsa02010	ABC transporters	5/1588	45/8135	0.9555	0.9975	0.8331	ABCA1/ABCC6/ABCC3/DEFB1/ABCB9	5
KEGG	hsa04614	Renin-angiotensin system	2/1588	23/8135	0.9557	0.9975	0.8331	THOP1/CTSA	2
KEGG	hsa05322	Systemic lupus erythematosus	18/1588	136/8135	0.9798	1	0.8352	HLA-DPA1/C1QC/HLA-DOA/HLA-DMA/C1QB/CD40/C8G/FCGR1A/HLA-DRA/CD80/HLA-DQA1/HLA-DPB1/ACTN1/C1R/C1QA/C5/HLA-DQB1/SNRPD3	18
KEGG	hsa04024	cAMP signaling pathway	32/1588	221/8135	0.9804	1	0.8352	ADCY3/PIK3CD/GABBR1/CAMK2G/ADCY9/ATP1B3/HCN4/CREBBP/ATP2A2/RAC2/GLP1R/RRAS2/GNAS/CALM1/TIAM1/GIPR/PAK1/GRIN3B/ATP1A3/ATP1A1/FOS/GLI3/PTGER2/ATP1B2/CREB3/ADCYAP1/CACNA1D/PIK3R2/SSTR2/CHRM2/PDE4D/ATP1B1	32
KEGG	hsa00140	Steroid hormone biosynthesis	6/1588	61/8135	0.9871	1	0.8352	SRD5A1/HSD11B1/SULT2B1/CYP1B1/STS/SULT1E1	6
KEGG	hsa05030	Cocaine addiction	4/1588	49/8135	0.9919	1	0.8352	GNAS/GRIN3B/DLG4/CREB3	4
KEGG	hsa05168	Herpes simplex virus 1 infection	77/1588	495/8135	0.992	1	0.8352	HLA-DPA1/ZNF33B/ZNF3/PIK3CD/ZNF699/APAF1/BCL2L1/CARD9/ZNF600/EIF2AK4/HLA-DOA/HLA-DMA/ZNF248/POU2F2/ZNF785/ZNF589/ZNF223/RHEB/CALR/PILRA/CFP/ZNF763/HLA-DRA/ZNF621/CCL2/ZNF33A/HLA-DQA1/TRAF2/HLA-DPB1/IRF3/ZNF430/ZNF786/IFNAR1/ZNF93/CCL5/ZNF749/ZNF398/ZNF577/BID/CASP8/TAPBP/C5/MYD88/TRAF3/ZNF177/ZNF688/ZNF549/HLA-DQB1/IKBKE/TSC2/ZNF570/ZNF133/ZNF224/ZNF343/ZNF772/ZNF79/ZNF746/ZNF557/ZNF331/EIF4EBP1/ZNF669/ZNF773/ZNF550/ZNF454/ZNF470/ZNF671/ZNF564/ZNF563/PIK3R2/ZNF20/ZNF74/BCL2/ZNF684/ZNF431/ZNF205/ZNF689/ITGA5	77
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/1588	23/8135	0.9933	1	0.8352	FKRP	1
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	12/1588	109/8135	0.9942	1	0.8352	UTP18/RCL1/NOB1/UTP6/RAN/NAT10/CSNK2A2/UTP15/RBM28/XPO1/WDR75/FBL	12
KEGG	hsa05033	Nicotine addiction	2/1588	40/8135	0.9982	1	0.8352	GRIN3B/CACNA1B	2
KEGG	hsa04742	Taste transduction	7/1588	86/8135	0.999	1	0.8352	PLCB1/PLCB2/TAS2R39/GABBR1/HCN4/TAS2R3/TAS2R38	7
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	4/1588	66/8135	0.9995	1	0.8352	CARS2/PARS2/SARS2/DARS2	4
KEGG	hsa00190	Oxidative phosphorylation	12/1588	134/8135	0.9998	1	0.8352	UQCRB/ATP6V1E2/ATP6V0A1/NDUFV3/SDHD/UQCRC1/NDUFB1/ATP6V0D1/ATP6AP1/NDUFA10/NDUFA4L2/COX15	12
KEGG	hsa05034	Alcoholism	19/1588	187/8135	0.9998	1	0.8352	GNG10/NRAS/HDAC8/HDAC10/HDAC9/KRAS/GNAS/SOS2/GRB2/CALM1/GNG2/ADORA2B/GRIN3B/CREB3/SLC29A3/GNG11/SLC29A2/GNB1/HRAS	19
KEGG	hsa04080	Neuroactive ligand-receptor interaction	42/1588	353/8135	1	1	0.8352	FPR3/F2RL1/P2RY11/P2RX7/LTB4R2/C3AR1/LEP/LTB4R/GABBR1/ADM/VIPR1/P2RX4/CHRNA2/OPRL1/GLP1R/UCN/GNRH2/PENK/P2RY13/TACR2/ADORA2B/C5/GZMA/FPR1/P2RY8/GIPR/CYSLTR1/GRIN3B/PTGER2/CSH2/EDNRB/P2RY10/P2RY6/GRM6/CHRNB1/S1PR3/S1PR4/ADCYAP1/MC1R/SSTR2/CHRM2/TAAR1	42
KEGG	hsa04740	Olfactory transduction	27/1588	440/8135	1	1	0.8352	ADCY3/SLC24A4/CAMK2G/RGS2/OR2F1/ARRB2/OR1L8/OR2AK2/OR4C13/SLC8A1/OR6B1/OR2M2/CALM1/OR10S1/OR7E24/OR51E2/OR52D1/OR2H2/OR2G3/OR51I2/OR8J1/OR51G2/OR4C3/GNB1/OR11G2/OR2AG1/OR2C3	27