ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04668	TNF signaling pathway	48/1169	112/8135	1.694e-13	5.659e-11	3.995e-11	CXCL1/CXCL2/CXCL6/NFKBIA/CCL20/BIRC3/ICAM1/TNFAIP3/CCL5/PTGS2/IL6/CXCL5/VCAM1/MAP3K8/CSF2/IL1B/LIF/CXCL10/NFKB1/CCL2/IRF1/MMP3/CSF1/CEBPB/BIRC2/PIK3CD/TNFRSF1B/CFLAR/TRAF3/IL18R1/SOCS3/CXCL3/FAS/FADD/ITCH/IL15/PIK3R2/EDN1/MAPK13/PIK3R3/RPS6KA4/MMP9/BCL3/JUNB/TRAF2/TNF/MLKL/CASP7	48
KEGG	hsa05164	Influenza A	54/1169	171/8135	5.612e-09	9.372e-07	6.616e-07	NFKBIA/BID/ICAM1/CCL5/IL6/IL1B/MX1/CXCL10/IL33/NFKB1/IRF9/CCL2/CDK6/IL1A/OAS1/IFIH1/IFNAR2/IFNGR1/IFNAR1/MX2/PIK3CD/PRKCA/OAS3/RSAD2/IFNGR2/STAT1/IRAK4/IRF7/TRAF3/NFKBIB/IL12A/SOCS3/TRIM25/OAS2/DDX58/FAS/ADAR/FADD/PIK3R2/NXF1/PIK3R3/STAT2/DNAJC3/TYK2/ACTB/TNF/TNFRSF10B/TLR3/HLA-DQB1/VDAC1/NXT1/KPNA2/TICAM1/ACTG1	54
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	56/1169	194/8135	9.957e-08	1.108e-05	7.826e-06	CXCL1/CXCL2/NFKBIA/BID/ICAM1/PTGS2/IL6/CSF2/PPP3CC/NFKB1/IRF9/CDK6/IFNAR2/IFNGR1/IFNAR1/FGF2/PIK3CD/C3/STAT1/IL6ST/VEGFA/IRF7/TRAF3/HLA-E/CXCL3/HLA-F/CALM1/FAS/CCND1/FADD/ZFP36/HLA-A/PIK3R2/GNG11/MAPK13/TCF7L2/E2F2/PIK3R3/STAT2/RCAN1/ITPR2/GNB4/TRAF2/MICB/TYK2/CALM2/TLR3/TCF7L1/HLA-G/PPP3CA/UBB/CDKN1A/TICAM1/STAT3/HLA-B/GNG2	56
KEGG	hsa05160	Hepatitis C	47/1169	157/8135	3.311e-07	2.765e-05	1.952e-05	NFKBIA/BID/CLDN1/MX1/CXCL10/NFKB1/IRF9/CDK6/OAS1/IFNAR2/IFNAR1/MX2/PIK3CD/OAS3/RSAD2/STAT1/CFLAR/IRF7/PPP2R1B/TRAF3/IFIT1/SOCS3/OAS2/RXRA/DDX58/FAS/CCND1/FADD/CLDN14/PIK3R2/EIF2AK4/E2F2/PIK3R3/STAT2/TRAF2/ARAF/CLDN20/TYK2/EIF3E/TNF/YWHAH/TLR3/CLDN7/CDKN1A/TICAM1/CLDN17/STAT3	47
KEGG	hsa04621	NOD-like receptor signaling pathway	52/1169	184/8135	5.919e-07	3.954e-05	2.791e-05	CXCL1/CXCL2/NFKBIA/BIRC3/TNFAIP3/NAMPT/CCL5/IL6/IL1B/RIPK2/NFKB1/IRF9/CCL2/OAS1/IFNAR2/IFNAR1/BIRC2/OAS3/GBP2/GABARAPL1/STAT1/PANX1/IRAK4/IRF7/TRAF3/NFKBIB/GBP5/CXCL3/OAS2/GBP3/FADD/GBP1/GBP4/CYBA/TRIP6/MAPK13/GSDMD/STAT2/ITPR2/PLCB4/TRAF2/BCL2L1/TXN/TYK2/TNF/PRKCD/RBCK1/VDAC1/PYDC2/PKN2/TICAM1/P2RX7	52
KEGG	hsa05169	Epstein-Barr virus infection	55/1169	202/8135	1.039e-06	5.785e-05	4.084e-05	NFKBIA/BID/ICAM1/TNFAIP3/IL6/RELB/TAP1/TAP2/CXCL10/NFKB1/IRF9/NFKB2/CDK6/OAS1/IFNAR2/IFNAR1/NFKBIE/ISG15/PIK3CD/OAS3/STAT1/IRAK4/IRF7/TRAF3/NFKBIB/HLA-E/CD44/HLA-F/CD58/CD40/OAS2/SAP30/DDX58/FAS/CCND1/FADD/HLA-A/PIK3R2/MAPK13/E2F2/PIK3R3/STAT2/DDB2/GADD45G/TRAF2/TYK2/TNF/HLA-G/HLA-DQB1/NCOR2/CDKN1A/TAPBP/STAT3/HLA-B/NEDD4	55
KEGG	hsa05205	Proteoglycans in cancer	55/1169	205/8135	1.719e-06	8.203e-05	5.791e-05	FLNC/HSPB2/FGF2/PIK3CD/PRKCA/PLCE1/VEGFA/ROCK1/PAK1/FZD1/COL1A1/PLAU/CD44/PPP1R12A/ITGB5/CAMK2D/FAS/CCND1/ANK3/HSPG2/THBS1/PIK3R2/MAPK13/RDX/PXN/FZD2/HBEGF/PIK3R3/TGFB2/SDC2/ITGA2/WNT5B/FLNB/MMP9/PPP1R12C/ITPR2/FZD8/WNT5A/ARAF/DDX5/ACTB/TNF/CAMK2G/FZD4/ARHGEF12/SDC4/COL1A2/ROCK2/CDKN1A/PTPN11/CDC42/IGF1/STAT3/ACTG1/FZD7	55
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/1169	100/8135	5.309e-06	0.0002216	0.0001565	ICAM1/IL6/VCAM1/IL1B/NFKB1/CCL2/PLCD3/IL1A/PIK3CD/PRKCA/PLCE1/PLCD1/FOXO1/STAT1/VEGFA/COL1A1/CCND1/PIM1/PIK3R2/EDN1/MAPK13/PIK3R3/TGFB2/PLCB4/TNF/COL4A1/DIAPH1/PRKCD/SERPINE1/COL1A2/CDC42/STAT3	32
KEGG	hsa04217	Necroptosis	44/1169	159/8135	7.883e-06	0.0002926	0.0002065	BIRC3/BID/TNFAIP3/IL1B/IL33/IRF9/STAT4/IL1A/IFNAR2/CHMP1B/SQSTM1/IFNGR1/IFNAR1/BIRC2/IFNGR2/PYGL/STAT1/PLA2G4A/CFLAR/PLA2G4C/CAMK2D/CHMP4B/FAS/FTH1/FADD/CYLD/GLUD1/STAT2/PPIA/STAT6/TRAF2/TYK2/TNF/MLKL/CAMK2G/TNFRSF10B/TLR3/CHMP5/RBCK1/VDAC1/ZBP1/TICAM1/STAT3/CAPN2	44
KEGG	hsa04810	Regulation of actin cytoskeleton	55/1169	218/8135	1.275e-05	0.0004029	0.0002844	BDKRB1/ITGA1/BDKRB2/FGF2/PIK3CD/ARPC1A/ROCK1/PAK1/PDGFRB/VCL/ACTR3/PPP1R12A/ITGB5/SSH1/ITGA4/MYL5/PIK3R2/RDX/PXN/PDGFD/F2R/PIK3R3/ITGB8/ITGA2/LPAR1/GNA13/FGD1/GNA12/PPP1R12C/ARPC2/ENAH/ARAF/ITGA11/PFN2/MYLK/GSN/ACTB/ACTN4/FGF5/PDGFC/ARHGEF12/DIAPH1/ITGAE/ROCK2/PIP4K2A/ACTR2/FGF10/CDC42/MYH9/MYH10/ITGA6/ACTG1/MYL12A/CRKL/WASF2	55
KEGG	hsa04625	C-type lectin receptor signaling pathway	32/1169	104/8135	1.327e-05	0.0004029	0.0002844	NFKBIA/PTGS2/IL6/IL1B/RELB/PPP3CC/NFKB1/IRF9/NFKB2/IRF1/PIK3CD/STAT1/PAK1/IL12A/CALM1/PIK3R2/CYLD/MAPK13/PIK3R3/STAT2/BCL3/ITPR2/TNF/CALM2/ARHGEF12/PRKCD/PPP3CA/BCL10/KSR1/PTPN11/LSP1/CBLB	32
KEGG	hsa05162	Measles	39/1169	139/8135	1.806e-05	0.0005028	0.0003549	NFKBIA/BID/TNFAIP3/IL6/IL1B/MX1/NFKB1/IRF9/CDK6/IL1A/OAS1/IFIH1/IFNAR2/IFNAR1/MX2/PIK3CD/OAS3/STAT1/RAB9A/IRAK4/IRF7/TRAF3/NFKBIB/IL12A/OAS2/DDX58/FAS/CCND1/ADAR/FADD/PIK3R2/EIF2AK4/PIK3R3/STAT2/BCL2L1/TYK2/RAB9B/CBLB/STAT3	39
KEGG	hsa04510	Focal adhesion	51/1169	201/8135	2.22e-05	0.0005704	0.0004026	BIRC3/ITGA1/FLNC/THBS2/BIRC2/PIK3CD/PRKCA/VEGFA/ROCK1/PAK1/PDGFRB/VCL/LAMB1/COL1A1/FYN/PPP1R12A/ITGB5/CCND1/VWF/ITGA4/THBS1/MYL5/PIK3R2/PXN/PDGFD/PIK3R3/ITGB8/ITGA2/FLNB/PPP1R12C/ITGA11/COL6A3/TNC/MYLK/ACTB/PGF/ACTN4/PDGFC/COL4A1/DIAPH1/ZYX/COL1A2/ROCK2/CDC42/IGF1/ITGA6/ACTG1/TLN1/MYL12A/CRKL/CAPN2	51
KEGG	hsa04380	Osteoclast differentiation	36/1169	128/8135	3.552e-05	0.0008108	0.0005724	NFKBIA/IL1B/RELB/PPP3CC/NFKB1/IRF9/NFKB2/IL1A/CSF1/IFNAR2/SQSTM1/IFNGR1/IFNAR1/PIK3CD/IFNGR2/STAT1/SOCS1/SOCS3/FYN/CYBA/FHL2/PIK3R2/CYLD/MAPK13/SIRPA/PIK3R3/TGFB2/STAT2/MITF/JUNB/TRAF2/TYK2/TNF/PPP3CA/PPARG/TNFRSF11B	36
KEGG	hsa05417	Lipid and atherosclerosis	53/1169	215/8135	3.641e-05	0.0008108	0.0005724	CXCL1/SOD2/CXCL2/NFKBIA/BID/ICAM1/CCL5/OLR1/IL6/MMP1/VCAM1/IL1B/PPP3CC/NFKB1/CCL2/ERN1/MMP3/ABCA1/PIK3CD/PRKCA/IRAK4/IRF7/TRAF3/IL12A/CCL3L3/CXCL3/POU2F2/CD40/CALM1/RXRA/CAMK2D/FAS/CCL3/CYBA/PIK3R2/MAPK13/PIK3R3/MMP9/PLCB4/TRAF2/BCL2L1/TNF/CAMK2G/CALM2/TNFRSF10B/PPP3CA/ROCK2/PPARG/TICAM1/CDC42/MIB1/STAT3/CASP7	53
KEGG	hsa05165	Human papillomavirus infection	74/1169	331/8135	4.4e-05	0.0009185	0.0006484	PTGS2/MX1/ITGA1/NFKB1/IRF9/THBS2/CDK6/IRF1/IFNAR2/IFNAR1/MX2/ISG15/PIK3CD/FOXO1/STAT1/VEGFA/ATP6V1E2/PPP2R1B/PDGFRB/TRAF3/LAMB1/HLA-E/FZD1/COL1A1/HLA-F/ATP6V0B/ITGB5/FAS/CCND1/VWF/ATP6V0E2/FADD/ITGA4/THBS1/HLA-A/OASL/PIK3R2/TCF7L2/PXN/FZD2/PIK3R3/STAT2/ITGB8/ITGA2/WNT5B/CHD4/FZD8/WNT5A/ITGA11/COL6A3/HES5/TNC/TYK2/TNF/HES3/PPP2R5E/FZD4/TLR3/COL4A1/TCF7L1/HLA-G/COL1A2/PPP2R5C/CDKN1A/TICAM1/CDC42/ITGA6/DVL1/DVL2/HLA-B/UBR4/FZD7/ATP6V1E1/TADA3	74
KEGG	hsa05323	Rheumatoid arthritis	28/1169	93/8135	6.988e-05	0.001315	0.0009286	CXCL1/CXCL2/CXCL6/CCL20/ICAM1/CCL5/IL6/CXCL5/MMP1/CSF2/IL1B/CCL2/MMP3/IL1A/CSF1/VEGFA/ATP6V1E2/TNFSF13B/CCL3L3/CXCL3/ATP6V0B/CCL3/ATP6V0E2/IL15/TGFB2/TNF/HLA-DQB1/ATP6V1E1	28
KEGG	hsa05131	Shigellosis	58/1169	247/8135	7.089e-05	0.001315	0.0009286	NFKBIA/CCL5/TNIP1/CYTH3/CSF2/IL1B/RIPK2/NFKB1/PLCD3/SQSTM1/PIK3CD/ARPC1A/FNBP1L/PLCE1/PLCD1/C3/FOXO1/HK2/ROCK1/VCL/NFKBIB/ACTR3/CD44/TIFA/WIPI1/MYL5/PIK3R2/MAPK13/PXN/PIK3R3/CAST/ITPR2/PLCB4/ARPC2/TRAF2/ARF6/BCL2L1/ARF1/PFN2/ACTB/TNF/ACTN4/DIAPH1/PRKCD/RBCK1/ROCK2/BCL10/VDAC1/UBB/ACTR2/CDC42/ACTG1/TLN1/MYL12A/FOXO4/CRKL/CAPN2/WASF2	58
KEGG	hsa04064	NF-kappa B signaling pathway	30/1169	104/8135	9.403e-05	0.001653	0.001167	CXCL1/CXCL2/NFKBIA/BIRC3/ICAM1/TNFAIP3/PTGS2/VCAM1/IL1B/RELB/NFKB1/NFKB2/BIRC2/IRAK4/CFLAR/TNFSF13B/TRAF3/CXCL3/PLAU/TRIM25/CD40/DDX58/CYLD/CARD10/GADD45G/TRAF2/BCL2L1/TNF/BCL10/TICAM1	30
KEGG	hsa05130	Pathogenic Escherichia coli infection	48/1169	197/8135	0.0001141	0.001905	0.001345	NFKBIA/IL6/CYTH3/IL1B/CLDN1/TUBB3/NFKB1/ARPC1A/ROCK1/IRAK4/PAK1/NFKBIB/ACTR3/FYN/FAS/FADD/CLDN14/MAPK13/MYO1E/F2R/LPAR1/GNA13/GNA12/ARPC2/TRAF2/ARF6/CLDN20/ARF1/ACTB/TNF/TNFRSF10B/ARHGEF12/ABL1/ROCK2/MYO10/CLDN7/TMED10/PTPN11/ACTR2/CDC42/TJP1/MYH9/MYH10/CLDN17/MYO1D/ACTG1/CASP7/WASF2	48
KEGG	hsa05163	Human cytomegalovirus infection	53/1169	225/8135	0.000132	0.0021	0.001483	NFKBIA/BID/CCL5/PTGS2/IL6/IL1B/TAP1/TAP2/PPP3CC/NFKB1/CCL2/CDK6/PIK3CD/PRKCA/VEGFA/ROCK1/HLA-E/CCL3L3/HLA-F/CALM1/FAS/CCND1/CCL3/FADD/HLA-A/PIK3R2/GNG11/MAPK13/PTGER2/PXN/E2F2/ADCY7/PIK3R3/GNA13/ADCY9/ADCY3/GNA12/ITPR2/PLCB4/GNB4/TRAF2/TNF/CALM2/ARHGEF12/HLA-G/PPP3CA/ROCK2/CDKN1A/TAPBP/STAT3/HLA-B/CRKL/GNG2	53
KEGG	hsa04657	IL-17 signaling pathway	27/1169	94/8135	0.0002239	0.0034	0.0024	CXCL1/CXCL2/CXCL6/NFKBIA/CCL20/TNFAIP3/PTGS2/IL6/CXCL5/MMP1/CSF2/IL1B/CXCL10/NFKB1/CCL2/MMP3/CCL7/CEBPB/TRAF3/CXCL3/TRAF3IP2/FADD/IL17RB/MAPK13/MMP9/TRAF2/TNF	27
KEGG	hsa05132	Salmonella infection	56/1169	249/8135	0.0003132	0.004548	0.00321	NFKBIA/BIRC3/IL6/CYTH3/IL1B/RIPK2/TUBB3/AHNAK2/NFKB1/FLNC/BIRC2/PIK3CD/ARPC1A/RAB9A/IRAK4/PAK1/ACTR3/RHOJ/FADD/MYL5/DYNC2LI1/MAPK13/GSDMD/TCF7L2/PODXL/GCC2/RHOB/DCTN1/FHOD1/KPNA3/FLNB/ARPC2/TRAF2/ARF6/ARF1/PFN2/TXN/ACTB/TNF/MLKL/DYNLL1/ACTR10/TNFRSF10B/ACBD3/RAB9B/TCF7L1/ROCK2/RALA/ACTR2/M6PR/CDC42/DCTN3/ACTG1/MYL12A/CASP7/DYNLT3	56
KEGG	hsa04060	Cytokine-cytokine receptor interaction	64/1169	295/8135	0.0003489	0.004856	0.003428	CXCL1/CXCL2/CXCL6/CCL20/BMP2/CCL5/IL6/IL32/CXCL5/CD70/CSF2/IL1B/LIF/CXCL10/IL33/CCL2/CCL8/IL1A/CSF1/IFNAR2/CCL7/TNFSF9/IFNGR1/IFNAR1/IL7R/OSMR/TNFRSF14/TNFRSF9/IFNGR2/TNFRSF1B/PF4V1/IL6ST/BMP4/TNFSF13B/IL12A/CCL3L3/IL18R1/IL4R/CXCL3/CD40/IL15RA/BMPR2/FAS/IL26/CXCL11/CCL3/IL15/IL17RB/CXCL9/INHBB/GHR/CCL1/TGFB2/EBI3/CLCF1/GDF5/GDF15/TNF/TNFRSF10B/IL12RB2/IL11RA/TNFRSF11B/GDF6/CCR10	64
KEGG	hsa05416	Viral myocarditis	19/1169	60/8135	0.0004933	0.006591	0.004653	BID/ICAM1/HLA-E/HLA-F/CD40/FYN/CCND1/HLA-A/SGCD/EIF4G3/ACTB/SGCG/HLA-G/HLA-DQB1/ABL1/MYH6/ACTG1/HLA-B/SGCB	19
KEGG	hsa05142	Chagas disease	27/1169	102/8135	0.0009209	0.01183	0.008351	NFKBIA/CCL5/IL6/IL1B/NFKB1/CCL2/BDKRB2/IFNGR1/PIK3CD/IFNGR2/C3/IRAK4/CFLAR/PPP2R1B/IL12A/CCL3L3/FAS/CCL3/FADD/PIK3R2/MAPK13/PIK3R3/TGFB2/PLCB4/TNF/SERPINE1/TICAM1	27
KEGG	hsa04115	p53 signaling pathway	21/1169	73/8135	0.001058	0.01309	0.009241	BID/CD82/CDK6/SESN1/FAS/CCND1/THBS1/PMAIP1/DDB2/SESN3/CCNG2/GADD45G/BCL2L1/SESN2/CCNG1/PPM1D/TNFRSF10B/ZMAT3/SERPINE1/CDKN1A/IGF1	21
KEGG	hsa04630	JAK-STAT signaling pathway	38/1169	162/8135	0.001229	0.01395	0.009846	IL6/CSF2/LIF/IRF9/STAT4/IFNAR2/IFNGR1/IFNAR1/FHL1/PIK3CD/IL7R/OSMR/IFNGR2/STAT1/IL6ST/PDGFRB/IL12A/IL4R/SOCS1/SOCS3/IL15RA/CCND1/IL15/PIM1/PIK3R2/GHR/PIK3R3/STAT2/STAT6/BCL2L1/TYK2/IL12RB2/IL11RA/SOCS2/CDKN1A/PTPN11/STAT3/PIAS3	38
KEGG	hsa04920	Adipocytokine signaling pathway	20/1169	69/8135	0.001245	0.01395	0.009846	NFKBIA/NFKB1/PPARGC1A/NFKBIE/TNFRSF1B/SLC2A1/ACACB/NFKBIB/SOCS3/RXRA/IRS1/CPT1A/ACSL5/ADIPOR2/TRAF2/CAMKK2/TNF/PRKAB2/PTPN11/STAT3	20
KEGG	hsa04620	Toll-like receptor signaling pathway	27/1169	104/8135	0.001265	0.01395	0.009846	NFKBIA/CCL5/IL6/MAP3K8/IL1B/CXCL10/NFKB1/IFNAR2/IFNAR1/PIK3CD/STAT1/IRAK4/IRF7/TRAF3/IL12A/CCL3L3/CD40/CXCL11/CCL3/FADD/PIK3R2/MAPK13/CXCL9/PIK3R3/TNF/TLR3/TICAM1	27
KEGG	hsa04390	Hippo signaling pathway	37/1169	157/8135	0.001294	0.01395	0.009846	BIRC3/BMP2/ID2/BIRC2/BMP4/PPP2R1B/NKD2/WWTR1/AFP/FZD1/WWC1/BMPR2/LATS2/CCND1/WTIP/TCF7L2/FZD2/TGFB2/SNAI2/WNT5B/YAP1/CSNK1E/GDF5/FZD8/WNT5A/ACTB/YWHAH/FZD4/DLG4/TCF7L1/SERPINE1/RASSF1/GDF6/DVL1/ACTG1/DVL2/FZD7	37
KEGG	hsa03050	Proteasome	15/1169	46/8135	0.001352	0.01411	0.009959	PSME2/PSMA6/PSMB10/PSMB8/PSMB7/PSME1/PSMB9/PSMA3/PSMA1/PSMB2/PSMB3/PSMA8/PSME4/PSMB5/PSMF1	15
KEGG	hsa04978	Mineral absorption	18/1169	60/8135	0.001394	0.01411	0.009959	MT1G/MT1M/MT1E/MT1A/MT1X/SLC11A2/MT2A/MT1H/MT1F/STEAP1/FTH1/VDR/SLC30A1/HMOX2/CYBRD1/SLC26A3/ATP1A4/STEAP2	18
KEGG	hsa04936	Alcoholic liver disease	34/1169	142/8135	0.0015	0.01439	0.01016	CXCL1/CXCL2/NFKBIA/IL6/IL1B/NFKB1/PPARGC1A/LPIN1/C3/FOXO1/IRAK4/ACACB/TRAF3/IL12A/CXCL3/FAS/CCND1/SCD/FADD/MAPK13/TCF7L2/CPT1A/ADH5/ACACA/ADIPOR2/SIRT1/CAMKK2/ALDH7A1/TNF/PRKAB2/TCF7L1/ADH1C/TICAM1/ACADM	34
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1169	100/8135	0.001508	0.01439	0.01016	CXCL1/CXCL2/CXCL6/CCL20/CCL5/IL6/CXCL5/CXCL10/CCL2/CCL8/CSF1/CCL7/TNFRSF14/TNFRSF1B/PF4V1/IL6ST/CCL3L3/IL18R1/CXCL3/CXCL11/CCL3/CXCL9/CCL1/TNF/TNFRSF10B/CCR10	26
KEGG	hsa05410	Hypertrophic cardiomyopathy	24/1169	90/8135	0.001553	0.01441	0.01017	IL6/ITGA1/ITGB5/LMNA/ITGA4/ACTC1/EDN1/SGCD/TGFB2/ITGB8/ITGA2/TPM4/ITGA11/ACTB/TNF/CACNA1F/SGCG/ATP2A2/PRKAB2/MYH6/IGF1/ITGA6/ACTG1/SGCB	24
KEGG	hsa05212	Pancreatic cancer	21/1169	76/8135	0.001851	0.01671	0.0118	PLD1/NFKB1/CDK6/PIK3CD/STAT1/VEGFA/CCND1/PIK3R2/TGFA/E2F2/PIK3R3/TGFB2/DDB2/GADD45G/ARAF/BCL2L1/RALBP1/RALA/CDKN1A/CDC42/STAT3	21
KEGG	hsa04922	Glucagon signaling pathway	27/1169	107/8135	0.001987	0.01722	0.01216	PPP3CC/PPARGC1A/PYGL/FOXO1/SLC2A1/ACACB/CALM1/CAMK2D/PRMT1/CPT1A/ACACA/PHKB/PPP4C/ITPR2/PLCB4/SIRT1/CAMK2G/LDHB/PDHB/CALM2/PRKAB2/GYS2/PPP3CA/PGAM4/PDE3B/PHKA2/SIK1	27
KEGG	hsa01212	Fatty acid metabolism	17/1169	57/8135	0.002011	0.01722	0.01216	ELOVL5/SCD/ELOVL7/ACAT1/HADH/PPT1/ACAT2/CPT1A/ACACA/ACSL5/CBR4/ELOVL2/HSD17B12/ACAA2/SCP2/ACADM/ELOVL3	17
KEGG	hsa04611	Platelet activation	30/1169	124/8135	0.002337	0.01951	0.01377	PIK3CD/PLA2G4A/ROCK1/COL1A1/FYN/PPP1R12A/PLA2G4C/VWF/PIK3R2/MAPK13/F2R/ADCY7/PIK3R3/ITGA2/GNA13/ADCY9/ADCY3/ITPR2/PLCB4/MYLK/ACTB/STIM1/ARHGEF12/COL1A2/ROCK2/ORAI1/PTGS1/ACTG1/TLN1/MYL12A	30
KEGG	hsa04670	Leukocyte transendothelial migration	28/1169	114/8135	0.002544	0.02072	0.01463	ICAM1/VCAM1/CLDN1/PIK3CD/PRKCA/ROCK1/JAM3/VCL/JAM2/ITGA4/CYBA/MYL5/CLDN14/PIK3R2/MAPK13/PXN/PIK3R3/MMP9/CLDN20/ACTB/ACTN4/ROCK2/CLDN7/PTPN11/CDC42/CLDN17/ACTG1/MYL12A	28
KEGG	hsa05171	Coronavirus disease - COVID-19	49/1169	232/8135	0.00297	0.02362	0.01668	NFKBIA/IL6/MMP1/CSF2/IL1B/MX1/CXCL10/NFKB1/IRF9/CCL2/MMP3/OAS1/IFIH1/IFNAR2/IFNAR1/MX2/ISG15/PIK3CD/PRKCA/OAS3/C3/STAT1/IL6ST/IRAK4/TRAF3/NFKBIB/IL12A/OAS2/DDX58/VWF/ADAR/RPS3A/PIK3R2/MAPK13/HBEGF/PIK3R3/STAT2/RPL7/RPL22/RPL36AL/RPL26L1/RPL37A/CFB/TYK2/TNF/TLR3/RPL15/STAT3/RPS18	49
KEGG	hsa05211	Renal cell carcinoma	19/1169	69/8135	0.003121	0.02425	0.01712	ARNT2/PIK3CD/EPAS1/SLC2A1/VEGFA/PAK1/ETS1/PIK3R2/EGLN1/TGFA/PIK3R3/TGFB2/FH/ARAF/TFE3/CDKN1A/PTPN11/CDC42/CRKL	19
KEGG	hsa05321	Inflammatory bowel disease	18/1169	65/8135	0.00371	0.02817	0.01988	IL6/IL1B/NFKB1/STAT4/IL1A/IFNGR1/IFNGR2/STAT1/IL12A/IL18R1/IL4R/TGFB2/STAT6/TNF/IL12RB2/GATA3/HLA-DQB1/STAT3	18
KEGG	hsa05414	Dilated cardiomyopathy	24/1169	96/8135	0.003917	0.02848	0.02011	ITGA1/ITGB5/LMNA/ITGA4/ACTC1/ADCY7/SGCD/TGFB2/ITGB8/ITGA2/ADCY9/ADCY3/TPM4/ITGA11/ACTB/TNF/CACNA1F/SGCG/ATP2A2/MYH6/IGF1/ITGA6/ACTG1/SGCB	24
KEGG	hsa05418	Fluid shear stress and atherosclerosis	32/1169	139/8135	0.003923	0.02848	0.02011	ICAM1/VCAM1/IL1B/NFKB1/CCL2/IL1A/SQSTM1/PIK3CD/VEGFA/BMP4/KLF2/GSTO1/CALM1/GSTA4/BMPR2/CYBA/PIK3R2/EDN1/MAPK13/PIK3R3/SDC2/MMP9/MEF2C/TXN/ACTB/TNF/ASS1/CALM2/SUMO3/SDC4/MGST2/ACTG1	32
KEGG	hsa04270	Vascular smooth muscle contraction	31/1169	134/8135	0.00415	0.02928	0.02067	ADORA2A/PRKCA/PLA2G4A/ROCK1/CALD1/CALM1/PPP1R12A/PLA2G4C/EDN1/ADM2/ADCY7/GNA13/ADCY9/ADCY3/GNA12/PPP1R12C/ITPR2/PLCB4/PLA2G12A/ARAF/RAMP1/MYLK/CACNA1F/CALM2/ARHGEF12/PRKCD/NPR2/ROCK2/NPPA/MYH9/MYH10	31
KEGG	hsa05143	African trypanosomiasis	12/1169	37/8135	0.004209	0.02928	0.02067	ICAM1/IL6/VCAM1/IL1B/PRKCA/IDO1/IL12A/FAS/PLCB4/TNF/HBB/NPPA	12
KEGG	hsa05225	Hepatocellular carcinoma	37/1169	168/8135	0.004488	0.03059	0.0216	CDK6/PIK3CD/PRKCA/GSTO1/FZD1/GSTA4/CCND1/SMARCD3/PIK3R2/TCF7L2/TGFA/E2F2/FZD2/PIK3R3/TGFB2/DDB2/WNT5B/SMARCA2/LRP5/GADD45G/FZD8/WNT5A/ARAF/BCL2L1/ACTB/FZD4/TCF7L1/ARID1A/PBRM1/SMARCE1/CDKN1A/MGST2/DVL1/ACTG1/DVL2/FZD7/PHF10	37
KEGG	hsa05222	Small cell lung cancer	23/1169	92/8135	0.004684	0.03129	0.02209	NFKBIA/BIRC3/PTGS2/NFKB1/CDK6/BIRC2/PIK3CD/TRAF3/LAMB1/RXRA/CCND1/PIK3R2/E2F2/PIK3R3/DDB2/ITGA2/GADD45G/TRAF2/BCL2L1/COL4A1/MAX/CDKN1A/ITGA6	23
KEGG	hsa00620	Pyruvate metabolism	14/1169	47/8135	0.004929	0.03228	0.02279	ACACB/ACAT1/ACAT2/ADH5/ACACA/FH/HAGH/ALDH7A1/LDHB/PDHB/ME1/LDHD/ACYP1/ADH1C	14
KEGG	hsa04062	Chemokine signaling pathway	41/1169	192/8135	0.00512	0.03289	0.02322	CXCL1/CXCL2/CXCL6/NFKBIA/CCL20/CCL5/CXCL5/CXCL10/NFKB1/CCL2/CCL8/CCL7/PIK3CD/PF4V1/STAT1/ROCK1/PAK1/NFKBIB/CCL3L3/CXCL3/CXCL11/CCL3/PIK3R2/GNG11/PXN/CXCL9/ADCY7/CCL1/PIK3R3/STAT2/ADCY9/ADCY3/PLCB4/GNB4/PRKCD/ROCK2/CDC42/STAT3/CCR10/CRKL/GNG2	41
KEGG	hsa05202	Transcriptional misregulation in cancer	41/1169	193/8135	0.005626	0.03545	0.02503	NFKBIZ/BIRC3/IL6/CSF2/NFKB1/ID2/MMP3/ARNT2/CEBPB/BIRC2/MEIS1/SIX1/FOXO1/DUSP6/PLAU/CD40/RXRA/HOXA11/HOXA10/DDB2/MITF/GRIA3/MMP9/GADD45G/SIX4/MEF2C/CDKN2C/ATF1/FLI1/BCL2L1/DDX5/BMP2K/ETV1/MLF1/HOXA9/TFE3/CEBPA/MAX/PPARG/CDKN1A/IGF1	41
KEGG	hsa04921	Oxytocin signaling pathway	34/1169	154/8135	0.006038	0.03734	0.02636	PTGS2/PPP3CC/PRKCA/PLA2G4A/EEF2K/ROCK1/CALM1/PPP1R12A/PLA2G4C/CAMK2D/CCND1/OXTR/ADCY7/RGS2/ADCY9/ADCY3/RCAN1/PPP1R12C/ITPR2/PLCB4/MEF2C/CAMKK2/MYLK/ACTB/CACNA1F/CAMK2G/CALM2/PRKAB2/PPP3CA/NPR2/ROCK2/CDKN1A/NPPA/ACTG1	34
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1169	106/8135	0.007326	0.04424	0.03123	PLD1/PRKCA/MAFB/RXRA/PDE4D/CYP27B1/PTHLH/HBEGF/ADCY7/GNA13/ADCY9/ADCY3/GNA12/LRP5/ITPR2/PLCB4/MMP17/MEF2C/VDR/ARAF/BGLAP/GATA3/PDE4B/MMP24/CDKN1A	25
KEGG	hsa04218	Cellular senescence	34/1169	156/8135	0.007418	0.04424	0.03123	IL6/PPP3CC/NFKB1/CDK6/IL1A/SQSTM1/PIK3CD/FOXO1/HLA-E/HLA-F/CALM1/ETS1/TRAF3IP2/CCND1/CDC25A/HLA-A/PIK3R2/MAPK13/ZFP36L2/E2F2/HIPK2/PIK3R3/TGFB2/GADD45G/ITPR2/SIRT1/CALM2/HLA-G/PPP3CA/SERPINE1/VDAC1/CDKN1A/HLA-B/CAPN2	34
KEGG	hsa04916	Melanogenesis	24/1169	101/8135	0.007713	0.0452	0.03191	KIT/PRKCA/FZD1/CALM1/CAMK2D/EDN1/TCF7L2/FZD2/MC1R/ADCY7/MITF/WNT5B/ADCY9/ADCY3/PLCB4/FZD8/WNT5A/CAMK2G/CALM2/FZD4/TCF7L1/DVL1/DVL2/FZD7	24
KEGG	hsa04622	RIG-I-like receptor signaling pathway	18/1169	70/8135	0.008568	0.0485	0.03424	NFKBIA/CXCL10/NFKB1/IFIH1/ISG15/IRF7/TRAF3/NFKBIB/IL12A/TRIM25/DDX58/FADD/CYLD/MAP3K1/MAPK13/DHX58/TRAF2/TNF	18
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/1169	70/8135	0.008568	0.0485	0.03424	CXCL1/CXCL2/NFKBIA/CCL5/NFKB1/ATP6V1E2/PAK1/JAM3/CXCL3/JAM2/ATP6V0B/ATP6V0E2/MAPK13/HBEGF/PTPN11/CDC42/TJP1/ATP6V1E1	18
KEGG	hsa05144	Malaria	14/1169	50/8135	0.008939	0.04881	0.03446	ICAM1/IL6/VCAM1/IL1B/CCL2/THBS2/IL12A/CD40/THBS1/TGFB2/SDC2/GYPB/TNF/HBB	14
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	23/1169	97/8135	0.009222	0.04881	0.03446	PLD1/ASAP3/PIK3CD/ARPC1A/PRKCA/PLA2G4A/PAK1/MARCKSL1/ACTR3/PLA2G4C/PIK3R2/PIK3R3/ARPC2/ARF6/GSN/ASAP1/PRKCD/MYO10/ACTR2/CDC42/CRKL/WASF2/ASAP2	23
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	45/1169	222/8135	0.009311	0.04881	0.03446	NFKBIA/ICAM1/IL6/CSF2/RELB/PPP3CC/NFKB1/NFKB2/PIK3CD/SLC2A1/HLA-E/HLA-F/CD40/IL15RA/ETS1/CCND1/CDC16/ZFP36/HLA-A/IL15/MSX2/PIK3R2/MAP3K1/E2F2/MAD1L1/ADCY7/PIK3R3/TGFB2/KAT2B/ADCY9/ADCY3/POLB/CDKN2C/ANAPC13/BCL2L1/TNF/HLA-G/PPP3CA/HLA-DQB1/VDAC1/CDKN1A/CDC23/HLA-B/TLN1/CRTC3	45
KEGG	hsa04071	Sphingolipid signaling pathway	27/1169	119/8135	0.009354	0.04881	0.03446	BID/S1PR3/PLD1/NFKB1/BDKRB2/PIK3CD/PRKCA/ROCK1/PPP2R1B/FYN/PIK3R2/MAPK13/PIK3R3/ABCC1/GNA13/GNA12/PLCB4/TRAF2/ADORA1/TNF/PPP2R5E/S1PR5/SGMS2/ROCK2/PPP2R5C/NSMAF/ADORA3	27
KEGG	hsa04722	Neurotrophin signaling pathway	27/1169	119/8135	0.009354	0.04881	0.03446	NFKBIA/IRAK2/RIPK2/NFKB1/NFKBIE/PIK3CD/IRAK4/NFKBIB/IRAK3/CALM1/SORT1/IRS1/CAMK2D/KIDINS220/PIK3R2/MAP3K1/MAPK13/PIK3R3/CAMK2G/CALM2/PRKCD/ABL1/ARHGDIB/PTPN11/CDC42/SH2B1/CRKL	27
KEGG	hsa05219	Bladder cancer	12/1169	41/8135	0.01038	0.05324	0.03758	MMP1/DAPK1/TYMP/VEGFA/CCND1/THBS1/E2F2/HBEGF/MMP9/ARAF/CDKN1A/RASSF1	12
KEGG	hsa04066	HIF-1 signaling pathway	25/1169	109/8135	0.01054	0.05324	0.03758	IL6/NFKB1/IFNGR1/PIK3CD/PRKCA/IFNGR2/SLC2A1/VEGFA/HK2/ENO2/CAMK2D/PIK3R2/MKNK2/EDN1/EGLN1/PIK3R3/CAMK2G/LDHB/PDHB/SERPINE1/CDKN1A/NPPA/IGF1/STAT3/ALDOC	25
KEGG	hsa04923	Regulation of lipolysis in adipocytes	15/1169	56/8135	0.01068	0.05324	0.03758	PTGS2/PIK3CD/IRS1/PIK3R2/ADCY7/PIK3R3/AQP7/ADCY9/ADCY3/ADORA1/ABHD5/ADRB3/PDE3B/PTGS1/NPPA	15
KEGG	hsa05140	Leishmaniasis	19/1169	77/8135	0.01112	0.0539	0.03805	NFKBIA/PTGS2/IL1B/NFKB1/IL1A/IFNGR1/IFNGR2/C3/STAT1/IRAK4/MARCKSL1/NFKBIB/IL12A/ITGA4/CYBA/MAPK13/TGFB2/TNF/HLA-DQB1	19
KEGG	hsa01200	Carbon metabolism	26/1169	115/8135	0.01113	0.0539	0.03805	ACO1/PRPS1/HK2/PSPH/PRPS1L1/ENO2/ADPGK/HIBCH/IDH1/ACAT1/GLUD1/ACAT2/ADH5/PSAT1/FH/RGN/AMT/ESD/PDHB/SDHD/PHGDH/ME1/CPS1/PGAM4/SUCLA2/ALDOC	26
KEGG	hsa05218	Melanoma	18/1169	72/8135	0.01157	0.0552	0.03897	CDK6/FGF2/PIK3CD/PDGFRB/CCND1/PIK3R2/E2F2/PDGFD/PIK3R3/DDB2/MITF/GADD45G/ARAF/FGF5/PDGFC/CDKN1A/FGF10/IGF1	18
KEGG	hsa05161	Hepatitis B	34/1169	162/8135	0.01321	0.06216	0.04388	NFKBIA/BID/IL6/NFKB1/STAT4/IFIH1/IFNAR1/PIK3CD/PRKCA/STAT1/IRAK4/IRF7/TRAF3/DDX58/FAS/FADD/HSPG2/PIK3R2/MAP3K1/MAPK13/E2F2/PIK3R3/TGFB2/STAT2/DDB2/STAT6/MMP9/ARAF/TYK2/TNF/TLR3/CDKN1A/TICAM1/STAT3	34
KEGG	hsa04623	Cytosolic DNA-sensing pathway	16/1169	63/8135	0.0144	0.06587	0.0465	NFKBIA/CCL5/IL6/IL1B/CXCL10/IL33/NFKB1/IRF7/NFKBIB/DDX58/POLR3GL/ADAR/POLR3D/POLR3K/ZBP1/POLR1C	16
KEGG	hsa05217	Basal cell carcinoma	16/1169	63/8135	0.0144	0.06587	0.0465	BMP2/BMP4/FZD1/TCF7L2/FZD2/DDB2/WNT5B/GADD45G/FZD8/WNT5A/FZD4/TCF7L1/CDKN1A/DVL1/DVL2/FZD7	16
KEGG	hsa04020	Calcium signaling pathway	47/1169	240/8135	0.01493	0.0674	0.04758	BDKRB1/PPP3CC/BDKRB2/PLCD3/ADORA2A/FGF2/PRKCA/PLCE1/PLCD1/PDE1C/VEGFA/PDGFRB/PTGFR/PPIF/CALM1/CAMK2D/PDE1A/OXTR/PDGFD/F2R/ADCY7/PHKB/ADCY9/ADCY3/ITPR2/PLCB4/ITPKA/TPCN1/MYLK/P2RX3/CACNA1F/CACNA1B/CAMK2G/CALM2/ATP2A2/STIM1/FGF5/PDGFC/ADRB3/PPP3CA/VDAC1/ORAI1/MCOLN1/PHKA2/FGF10/P2RX7/CASQ1	47
KEGG	hsa04924	Renin secretion	17/1169	69/8135	0.01605	0.07147	0.05045	PPP3CC/PDE1C/CALM1/PDE1A/EDN1/PTGER2/ITPR2/PLCB4/ADORA1/CACNA1F/CALM2/ADRB3/PPP3CA/ORAI1/PDE3B/NPPA/CLCA1	17
KEGG	hsa04392	Hippo signaling pathway - multiple species	9/1169	29/8135	0.01703	0.0745	0.05259	PAK1/WWTR1/WWC1/LATS2/WTIP/YAP1/CSNK1E/DCHS2/RASSF1	9
KEGG	hsa04120	Ubiquitin mediated proteolysis	30/1169	142/8135	0.0175	0.0745	0.05259	BIRC3/UBE2L6/BIRC2/MID1/UBE4A/SOCS1/SOCS3/CDC16/TRIM37/ITCH/UBA7/MAP3K1/UBR5/UBE2Q2/UBE2M/DDB2/PPIL2/ANAPC13/UBE2E1/BIRC6/DET1/KLHL13/UBB/UBE2Z/CDC23/UBE4B/CBLB/NEDD4/PIAS3/UBE2S	30
KEGG	hsa05214	Glioma	18/1169	75/8135	0.01757	0.0745	0.05259	CDK6/PIK3CD/PRKCA/PDGFRB/CALM1/CAMK2D/CCND1/PIK3R2/TGFA/E2F2/PIK3R3/DDB2/GADD45G/ARAF/CAMK2G/CALM2/CDKN1A/IGF1	18
KEGG	hsa04931	Insulin resistance	24/1169	108/8135	0.01762	0.0745	0.05259	NFKBIA/GFPT2/IL6/NFKB1/PPARGC1A/PIK3CD/SLC27A3/PYGL/FOXO1/SLC2A1/ACACB/SOCS3/IRS1/TBC1D4/PIK3R2/TRIB3/CPT1A/PIK3R3/TNF/PRKAB2/PRKCD/GYS2/PTPN11/STAT3	24
KEGG	hsa04068	FoxO signaling pathway	28/1169	131/8135	0.01829	0.07637	0.05391	SOD2/IL6/PIK3CD/IL7R/FOXO1/GABARAPL1/PLK2/KLF2/IRS1/CCND1/PIK3R2/STK4/PRMT1/MAPK13/PIK3R3/TGFB2/CCNG2/CSNK1E/GADD45G/SIRT1/ARAF/PRKAB2/CDKN1A/IGF1/STAT3/HOMER2/FOXO4/SGK3	28
KEGG	hsa05135	Yersinia infection	29/1169	137/8135	0.01877	0.07741	0.05465	NFKBIA/IL6/IL1B/NFKB1/CCL2/PIK3CD/ARPC1A/ROCK1/IRAK4/ACTR3/ITGA4/PIK3R2/MAPK13/PXN/PIK3R3/ARPC2/TRAF2/ARF6/ACTB/TNF/ARHGEF12/ROCK2/ACTR2/PKN2/TICAM1/CDC42/ACTG1/CRKL/WASF2	29
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	30/1169	143/8135	0.0192	0.07822	0.05522	LIF/ID2/FGF2/MEIS1/PIK3CD/JARID2/IL6ST/BMP4/FZD1/BMPR2/KLF4/PIK3R2/MAPK13/INHBB/FZD2/PIK3R3/WNT5B/ZFHX3/FZD8/WNT5A/FZD4/ID3/IGF1/STAT3/DVL1/DVL2/FZD7/SMARCAD1/SMAD9/TBX3	30
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	22/1169	98/8135	0.02005	0.08069	0.05696	BDKRB1/IL1B/BDKRB2/PIK3CD/PRKCA/PLA2G4A/CALM1/PLA2G4C/CAMK2D/PIK3R2/MAPK13/PTGER2/ADCY7/PIK3R3/ADCY9/ADCY3/ITPR2/PLCB4/CAMK2G/CALM2/PRKCD/IGF1	22
KEGG	hsa04919	Thyroid hormone signaling pathway	26/1169	121/8135	0.02102	0.08306	0.05863	PLCD3/DIO2/PIK3CD/PRKCA/PLCE1/PLCD1/FOXO1/SLC2A1/STAT1/BMP4/RXRA/CCND1/TBC1D4/MED13L/PIK3R2/PIK3R3/KAT2B/THRA/RCAN1/PLCB4/ACTB/ATP2A2/ATP1A4/MYH6/RCAN2/ACTG1	26
KEGG	hsa04146	Peroxisome	19/1169	82/8135	0.02147	0.08306	0.05863	SOD2/ACOX2/IDH1/NUDT7/CROT/MPV17L2/AMACR/PXMP4/ACSL5/ABCD1/DECR2/PEX11G/PEX1/PEX11B/ACOT8/PECR/SCP2/FAR1/PEX26	19
KEGG	hsa05110	Vibrio cholerae infection	13/1169	50/8135	0.0215	0.08306	0.05863	PRKCA/ATP6V1E2/ATP6V0B/SEC61G/ATP6V0E2/SLC12A2/ADCY9/ADCY3/ARF1/ACTB/TJP1/ACTG1/ATP6V1E1	13
KEGG	hsa04010	MAPK signaling pathway	55/1169	294/8135	0.02163	0.08306	0.05863	MAP3K8/IL1B/RELB/PPP3CC/NFKB1/FLNC/NFKB2/HSPB1/IL1A/CSF1/KIT/FGF2/PRKCA/DAXX/DUSP6/PLA2G4A/VEGFA/EREG/IRAK4/PAK1/PDGFRB/PLA2G4C/FAS/MAP3K1/MKNK2/STK4/MAPK13/TGFA/PDGFD/TGFB2/RPS6KA4/FLNB/GNA12/DUSP3/GADD45G/MEF2C/TRAF2/ARAF/TNF/MAP3K2/CACNA1F/PGF/CACNA1B/FGF5/PDGFC/DUSP16/PPP3CA/DUSP10/MAX/FGF10/CDC42/DUSP5/IGF1/TAOK1/CRKL	55
KEGG	hsa04211	Longevity regulating pathway	20/1169	89/8135	0.02553	0.09689	0.0684	SOD2/NFKB1/PPARGC1A/PIK3CD/FOXO1/SESN1/IRS1/PIK3R2/ADCY7/PIK3R3/SESN3/ADIPOR2/ADCY9/ADCY3/SIRT1/CAMKK2/SESN2/PRKAB2/PPARG/IGF1	20
KEGG	hsa00120	Primary bile acid biosynthesis	6/1169	17/8135	0.02616	0.09819	0.06931	CH25H/ACOX2/AMACR/HSD3B7/ACOT8/SCP2	6
KEGG	hsa05134	Legionellosis	14/1169	57/8135	0.02806	0.1041	0.07351	CXCL1/CXCL2/NFKBIA/IL6/IL1B/NFKB1/NFKB2/C3/IL12A/CXCL3/ARF1/TNF/CLK4/CASP7	14
KEGG	hsa05146	Amoebiasis	22/1169	102/8135	0.03073	0.1118	0.07892	CXCL1/CXCL2/IL6/CSF2/IL1B/NFKB1/HSPB1/PIK3CD/PRKCA/VCL/LAMB1/IL12A/CXCL3/COL1A1/PIK3R2/PIK3R3/TGFB2/PLCB4/TNF/ACTN4/COL4A1/COL1A2	22
KEGG	hsa05332	Graft-versus-host disease	11/1169	42/8135	0.03137	0.1118	0.07892	IL6/IL1B/IL1A/HLA-E/HLA-F/FAS/HLA-A/TNF/HLA-G/HLA-DQB1/HLA-B	11
KEGG	hsa04144	Endocytosis	47/1169	251/8135	0.03144	0.1118	0.07892	CYTH3/PLD1/EHD4/CHMP1B/DAB2/ASAP3/ARPC1A/PSD4/ZFYVE27/HLA-E/ACTR3/HLA-F/EPS15/IQSEC1/CHMP4B/SNX4/ITCH/HLA-A/VPS37D/CLTC/VPS36/VPS37C/RAB11FIP2/RAB4A/IGF2R/EHD1/ARPC2/CAPZA2/VPS35/ARF6/ARF1/ARF3/ASAP1/HLA-G/CHMP5/RAB11FIP1/ACTR2/CDC42/CBLB/RAB31/HLA-B/NEDD4/PDCD6IP/VPS26A/VPS45/ASAP2/SNX3	47
KEGG	hsa00062	Fatty acid elongation	8/1169	27/8135	0.03146	0.1118	0.07892	ELOVL5/ELOVL7/HADH/PPT1/ELOVL2/HSD17B12/ACAA2/ELOVL3	8
KEGG	hsa04724	Glutamatergic synapse	24/1169	114/8135	0.0324	0.1135	0.08016	PPP3CC/PLD1/PRKCA/GLS/PLA2G4A/SLC38A2/PLA2G4C/GNG11/TRPC1/ADCY7/GRIA3/ADCY9/ADCY3/ITPR2/PLCB4/GNB4/DLG4/GRM2/GRIK4/PPP3CA/GRIN3A/SLC38A1/HOMER2/GNG2	24
KEGG	hsa04022	cGMP-PKG signaling pathway	33/1169	167/8135	0.03291	0.1135	0.08016	PPP3CC/BDKRB2/ROCK1/PPIF/CALM1/PPP1R12A/IRS1/ADCY7/RGS2/GNA13/ADCY9/ADCY3/GNA12/ITPR2/PLCB4/MEF2C/ADORA1/MYLK/CACNA1F/CALM2/ATP2A2/ADRB3/PPP3CA/NPR2/ROCK2/VDAC1/PDE3B/ATP1A4/MYH6/NPPA/PDE5A/ADORA3/ADRA2A	33
KEGG	hsa05215	Prostate cancer	21/1169	97/8135	0.03297	0.1135	0.08016	NFKBIA/NFKB1/MMP3/PIK3CD/FOXO1/PDGFRB/PLAU/CCND1/PIK3R2/TCF7L2/TGFA/E2F2/PDGFD/PIK3R3/MMP9/ARAF/NKX3-1/PDGFC/TCF7L1/CDKN1A/IGF1	21
KEGG	hsa00280	Valine, leucine and isoleucine degradation	12/1169	48/8135	0.03547	0.1209	0.08534	HIBCH/BCKDHB/IL4I1/ACAT1/HADH/ACAT2/HIBADH/ALDH7A1/ACAA2/ABAT/BCAT2/ACADM	12
KEGG	hsa00071	Fatty acid degradation	11/1169	43/8135	0.03687	0.1221	0.08618	CYP2U1/ACAT1/HADH/ACAT2/CPT1A/ADH5/ACSL5/ALDH7A1/ACAA2/ADH1C/ACADM	11
KEGG	hsa04940	Type I diabetes mellitus	11/1169	43/8135	0.03687	0.1221	0.08618	IL1B/IL1A/HLA-E/IL12A/HLA-F/FAS/HLA-A/TNF/HLA-G/HLA-DQB1/HLA-B	11
KEGG	hsa04370	VEGF signaling pathway	14/1169	59/8135	0.03692	0.1221	0.08618	PTGS2/PPP3CC/HSPB1/PIK3CD/PRKCA/PLA2G4A/VEGFA/PLA2G4C/PIK3R2/MAPK13/PXN/PIK3R3/PPP3CA/CDC42	14
KEGG	hsa05330	Allograft rejection	10/1169	38/8135	0.03801	0.1245	0.08786	HLA-E/IL12A/HLA-F/CD40/FAS/HLA-A/TNF/HLA-G/HLA-DQB1/HLA-B	10
KEGG	hsa05220	Chronic myeloid leukemia	17/1169	76/8135	0.03904	0.1259	0.08891	NFKBIA/NFKB1/CDK6/PIK3CD/CCND1/PIK3R2/E2F2/PIK3R3/TGFB2/DDB2/GADD45G/ARAF/BCL2L1/ABL1/CDKN1A/PTPN11/CRKL	17
KEGG	hsa04912	GnRH signaling pathway	20/1169	93/8135	0.03921	0.1259	0.08891	PLD1/PRKCA/PLA2G4A/CALM1/PLA2G4C/CAMK2D/MAP3K1/MAPK13/HBEGF/ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/MAP3K2/CACNA1F/CAMK2G/CALM2/PRKCD/CDC42	20
KEGG	hsa04512	ECM-receptor interaction	19/1169	88/8135	0.04213	0.134	0.09462	ITGA1/THBS2/LAMB1/COL1A1/CD44/ITGB5/VWF/HSPG2/ITGA4/THBS1/ITGB8/ITGA2/ITGA11/COL6A3/TNC/COL4A1/SDC4/COL1A2/ITGA6	19
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1169	77/8135	0.04365	0.1375	0.0971	ITGA1/ITGB5/LMNA/ITGA4/TCF7L2/SGCD/ITGB8/ITGA2/ITGA11/ACTB/CACNA1F/SGCG/ATP2A2/TCF7L1/ITGA6/ACTG1/SGCB	17
KEGG	hsa05224	Breast cancer	29/1169	147/8135	0.04427	0.1382	0.09754	NFKB2/CDK6/KIT/FGF2/PIK3CD/FZD1/CCND1/PIK3R2/TCF7L2/E2F2/FZD2/PIK3R3/DDB2/WNT5B/LRP5/GADD45G/FZD8/WNT5A/ARAF/HES5/FZD4/FGF5/TCF7L1/CDKN1A/FGF10/IGF1/DVL1/DVL2/FZD7	29
KEGG	hsa00513	Various types of N-glycan biosynthesis	10/1169	39/8135	0.04477	0.1385	0.09775	MAN1A1/B4GALT3/MAN1C1/MGAT1/MGAT2/CHST8/ST3GAL3/ALG3/DAD1/ALG13	10
KEGG	hsa05223	Non-small cell lung cancer	16/1169	72/8135	0.0468	0.1434	0.1012	CDK6/PIK3CD/PRKCA/RXRA/CCND1/PIK3R2/STK4/TGFA/E2F2/PIK3R3/DDB2/GADD45G/ARAF/CDKN1A/RASSF1/STAT3	16
KEGG	hsa04210	Apoptosis	27/1169	136/8135	0.04754	0.1444	0.1019	NFKBIA/BIRC3/BID/NFKB1/ERN1/BIRC2/PIK3CD/DAXX/CFLAR/CTSS/FAS/LMNA/FADD/PIK3R2/PTPN13/PMAIP1/PIK3R3/GADD45G/ITPR2/TRAF2/BCL2L1/ACTB/TNF/TNFRSF10B/ACTG1/CASP7/CAPN2	27
KEGG	hsa05221	Acute myeloid leukemia	15/1169	67/8135	0.05015	0.1509	0.1065	CSF2/NFKB1/KIT/PIK3CD/DUSP6/PIM2/CCND1/PIM1/PIK3R2/TCF7L2/PIK3R3/ARAF/CEBPA/TCF7L1/STAT3	15
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	26/1169	131/8135	0.05126	0.1529	0.1079	BID/ICAM1/CSF2/PPP3CC/IFNAR2/IFNGR1/IFNAR1/PIK3CD/PRKCA/IFNGR2/PAK1/HLA-E/FYN/FAS/HLA-A/PIK3R2/PIK3R3/ARAF/MICB/TNF/TNFRSF10B/HLA-G/PPP3CA/NCR1/PTPN11/HLA-B	26
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1169	15/8135	0.05255	0.1553	0.1097	ST3GAL1/ST8SIA1/A4GALT/NAGA/GLA	5
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/1169	79/8135	0.05403	0.1562	0.1102	IL6/FGF2/PIK3CD/PRKCA/VEGFA/PDGFRB/PIK3R2/TGFA/PDGFD/PIK3R3/AXL/ARAF/BCL2L1/PDGFC/GAS6/IGF1/STAT3	17
KEGG	hsa04659	Th17 cell differentiation	22/1169	108/8135	0.05409	0.1562	0.1102	NFKBIA/IL6/IL1B/PPP3CC/NFKB1/IFNGR1/NFKBIE/IFNGR2/AHR/STAT1/IL6ST/NFKBIB/IL4R/RXRA/MAPK13/EBI3/STAT6/TYK2/GATA3/PPP3CA/HLA-DQB1/STAT3	22
KEGG	hsa05152	Tuberculosis	34/1169	180/8135	0.05424	0.1562	0.1102	BID/IRAK2/IL6/IL1B/PPP3CC/RIPK2/NFKB1/IL1A/CEBPB/IFNGR1/IFNGR2/C3/STAT1/IRAK4/CTSS/IL12A/ATP6V0B/CALM1/CAMK2D/FADD/MAPK13/CYP27B1/TGFB2/VDR/TNF/CAMK2G/CALM2/ARHGEF12/PPP3CA/HLA-DQB1/RFX5/BCL10/KSR1/LSP1	34
KEGG	hsa01523	Antifolate resistance	8/1169	30/8135	0.05625	0.1606	0.1134	IL6/IL1B/NFKB1/ABCC1/ABCC2/ABCG2/TNF/SLC19A1	8
KEGG	hsa04930	Type II diabetes mellitus	11/1169	46/8135	0.05734	0.1623	0.1146	PIK3CD/HK2/SOCS1/SOCS3/IRS1/PIK3R2/PIK3R3/TNF/CACNA1B/SOCS2/PRKCD	11
KEGG	hsa04530	Tight junction	32/1169	169/8135	0.05874	0.1649	0.1164	CLDN1/ARPC1A/ROCK1/RAB13/PPP2R1B/JAM3/CGNL1/ACTR3/JAM2/EPB41L4B/CCND1/CLDN14/MAP3K1/RDX/AMOTL1/ARPC2/CLDN20/ACTB/ACTN4/PRKAB2/ROCK2/CLDN7/MPDZ/ACTR2/CDC42/TJP1/MYH9/MYH10/CLDN17/ACTG1/MYL12A/NEDD4	32
KEGG	hsa03250	Viral life cycle - HIV-1	14/1169	63/8135	0.06031	0.1679	0.1185	MX1/MX2/APOBEC3G/ELL2/CHMP4B/APOBEC3H/KAT2B/MAP1A/PPIA/CPSF6/APOBEC3F/ELL/BICD2/PDCD6IP	14
KEGG	hsa04014	Ras signaling pathway	42/1169	232/8135	0.06378	0.1752	0.1237	PLD1/NFKB1/CSF1/KIT/FGF2/PIK3CD/PRKCA/PLCE1/PLA2G4A/VEGFA/PAK1/PDGFRB/CALM1/ETS1/PLA2G4C/PIK3R2/GNG11/STK4/TGFA/PDGFD/PIK3R3/GNB4/PLA2G12A/ARF6/BCL2L1/PGF/CALM2/FGF5/PDGFC/RALBP1/ABL1/RALA/KSR1/PTPN11/FGF10/RASSF1/RIN1/CDC42/IGF1/SHOC2/FOXO4/GNG2	42
KEGG	hsa01230	Biosynthesis of amino acids	16/1169	75/8135	0.06451	0.1752	0.1237	ACO1/PRPS1/MAT2A/PSPH/PRPS1L1/ENO2/IDH1/PSAT1/MTR/ASS1/ASNS/PHGDH/CPS1/PGAM4/ALDOC/BCAT2	16
KEGG	hsa03320	PPAR signaling pathway	16/1169	75/8135	0.06451	0.1752	0.1237	OLR1/MMP1/GK/ACOX2/PLIN2/FABP3/RXRA/SCD/DBI/CPT1A/AQP7/ACSL5/ME1/SCP2/PPARG/ACADM	16
KEGG	hsa04151	PI3K-Akt signaling pathway	61/1169	354/8135	0.0703	0.1894	0.1337	IL6/ITGA1/NFKB1/THBS2/CDK6/CSF1/IFNAR2/KIT/IFNAR1/FGF2/PIK3CD/IL7R/PRKCA/OSMR/VEGFA/EREG/PPP2R1B/PDGFRB/LAMB1/MYB/IL4R/COL1A1/RXRA/ITGB5/IRS1/CCND1/VWF/ITGA4/THBS1/PIK3R2/GNG11/TGFA/GHR/PDGFD/F2R/PIK3R3/ITGB8/ITGA2/LPAR1/GNB4/ITGA11/COL6A3/BCL2L1/MTCP1/TNC/PGF/YWHAH/PPP2R5E/FGF5/PDGFC/COL4A1/GYS2/COL1A2/PPP2R5C/CDKN1A/FGF10/PKN2/IGF1/ITGA6/SGK3/GNG2	61
KEGG	hsa05133	Pertussis	16/1169	76/8135	0.0713	0.1905	0.1345	CXCL6/IL6/CXCL5/IL1B/NFKB1/IRF1/IL1A/C3/IRAK4/IL12A/CALM1/MAPK13/TNF/CALM2/TICAM1/CASP7	16
KEGG	hsa04072	Phospholipase D signaling pathway	28/1169	148/8135	0.07392	0.1932	0.1364	CYTH3/PLD1/KIT/PIK3CD/PRKCA/PLA2G4A/PDGFRB/PTGFR/FYN/PLA2G4C/PIK3R2/PDGFD/F2R/ADCY7/PIK3R3/LPAR1/GNA13/ADCY9/ADCY3/GNA12/PLCB4/ARF6/ARF1/DGKI/PDGFC/GRM2/RALA/PTPN11	28
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	9/1169	37/8135	0.07406	0.1932	0.1364	GFPT2/GLS/IL4I1/GLUD1/ABAT/ASS1/ASNS/ALDH5A1/CPS1	9
KEGG	hsa05216	Thyroid cancer	9/1169	37/8135	0.07406	0.1932	0.1364	RXRA/CCND1/CCDC6/TCF7L2/DDB2/GADD45G/TCF7L1/PPARG/CDKN1A	9
KEGG	hsa05145	Toxoplasmosis	22/1169	112/8135	0.0754	0.1952	0.1378	NFKBIA/BIRC3/NFKB1/IFNGR1/BIRC2/IFNGR2/STAT1/IRAK4/NFKBIB/LAMB1/IL12A/SOCS1/PPIF/CD40/MAPK13/TGFB2/BCL2L1/TYK2/TNF/HLA-DQB1/STAT3/ITGA6	22
KEGG	hsa04215	Apoptosis - multiple species	8/1169	32/8135	0.07817	0.1986	0.1402	BIRC3/BID/BIRC2/FADD/PMAIP1/BCL2L1/BIRC6/CASP7	8
KEGG	hsa04934	Cushing syndrome	29/1169	155/8135	0.07844	0.1986	0.1402	CDK6/AHR/FZD1/CAMK2D/CCND1/RASD1/TCF7L2/E2F2/FZD2/ADCY7/FH/WNT5B/ADCY9/ADCY3/ITPR2/PLCB4/FZD8/CDKN2C/WNT5A/CACNA1F/CAMK2G/FZD4/RBBP5/TCF7L1/ORAI1/CDKN1A/DVL1/DVL2/FZD7	29
KEGG	hsa05100	Bacterial invasion of epithelial cells	16/1169	77/8135	0.07855	0.1986	0.1402	PIK3CD/ARPC1A/VCL/ACTR3/PIK3R2/PXN/CLTC/PIK3R3/ARPC2/ACTB/ARHGAP10/ACTR2/CDC42/ACTG1/CRKL/WASF2	16
KEGG	hsa04514	Cell adhesion molecules	28/1169	149/8135	0.0791	0.1986	0.1402	ICAM1/VCAM1/CLDN1/MPZL1/PDCD1LG2/JAM3/CNTNAP1/HLA-E/JAM2/HLA-F/CD58/CD40/VCAN/ITGA4/HLA-A/CLDN14/SDC2/ITGB8/CLDN20/PTPRM/HLA-G/SDC4/HLA-DQB1/CLDN7/CLDN17/CDH4/ITGA6/HLA-B	28
KEGG	hsa04910	Insulin signaling pathway	26/1169	137/8135	0.08024	0.2	0.1412	PPARGC1A/PIK3CD/PYGL/FOXO1/HK2/PPP1R3F/ACACB/SOCS1/SOCS3/CALM1/IRS1/PIK3R2/MKNK2/ACACA/PIK3R3/PHKB/FLOT1/ARAF/CALM2/SOCS2/PRKAB2/GYS2/PDE3B/PHKA2/CBLB/CRKL	26
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	7/1169	27/8135	0.08184	0.2025	0.1429	ELOVL5/SCD/ELOVL7/ELOVL2/HSD17B12/SCP2/ELOVL3	7
KEGG	hsa05010	Alzheimer disease	65/1169	384/8135	0.08448	0.2075	0.1465	SLC39A14/BID/PTGS2/IL6/IL1B/SLC11A2/PPP3CC/TUBB3/NFKB1/PSMA6/ERN1/IL1A/CSF1/PIK3CD/PSMB7/BACE2/FZD1/PPIF/CALM1/IRS1/FAS/PSMA3/BACE1/FADD/WIPI1/SLC39A10/NDUFB7/PIK3R2/SLC39A8/FZD2/PIK3R3/WNT5B/NDUFS4/APH1B/CSNK1E/LRP5/PSMA1/ITPR2/PLCB4/FZD8/PSMB2/CDK5/NDUFAB1/WNT5A/TRAF2/ARAF/PSENEN/PSMB3/TNF/CACNA1F/CALM2/ATP2A2/SDHD/FZD4/PSMA8/RTN4/PPP3CA/VDAC1/PSMB5/DVL1/DVL2/FZD7/UQCRHL/CASP7/CAPN2	65
KEGG	hsa04360	Axon guidance	33/1169	182/8135	0.09027	0.2201	0.1554	PPP3CC/NTN1/PIK3CD/PRKCA/ROCK1/PAK1/FYN/SLIT2/CAMK2D/BMPR2/SSH1/MYL5/PIK3R2/SEMA4D/TRPC1/PIK3R3/WNT5B/EFNB1/ROBO1/CDK5/WNT5A/ENAH/CAMK2G/ARHGEF12/PPP3CA/ABL1/ROCK2/PTPN11/EPHA1/CDC42/SEMA4F/MYL12A/NGEF	33
KEGG	hsa01524	Platinum drug resistance	15/1169	73/8135	0.09348	0.2262	0.1597	BIRC3/BID/BIRC2/PIK3CD/GSTO1/GSTA4/FAS/FADD/PIK3R2/PMAIP1/PIK3R3/ABCC2/BCL2L1/CDKN1A/MGST2	15
KEGG	hsa04070	Phosphatidylinositol signaling system	19/1169	97/8135	0.0955	0.2295	0.162	PLCD3/PIK3CD/PRKCA/PLCE1/PLCD1/CALM1/PIK3R2/PIK3R3/IMPA2/ITPR2/PLCB4/ITPKA/DGKI/CALM2/INPP5B/IP6K3/PIP4K2A/INPP1/PI4K2B	19
KEGG	hsa04213	Longevity regulating pathway - multiple species	13/1169	62/8135	0.09981	0.2381	0.1681	SOD2/PIK3CD/FOXO1/IRS1/PIK3R2/CRYAB/ADCY7/PIK3R3/ADCY9/ADCY3/SIRT1/PRKAB2/IGF1	13
KEGG	hsa02010	ABC transporters	10/1169	45/8135	0.1022	0.2422	0.171	TAP1/TAP2/ABCA1/ABCA5/ABCC1/ABCB10/ABCD1/ABCC2/ABCG2/ABCC11	10
KEGG	hsa04658	Th1 and Th2 cell differentiation	18/1169	92/8135	0.1035	0.2434	0.1718	NFKBIA/PPP3CC/NFKB1/STAT4/IFNGR1/NFKBIE/IFNGR2/STAT1/NFKBIB/IL12A/IL4R/MAPK13/STAT6/TYK2/IL12RB2/GATA3/PPP3CA/HLA-DQB1	18
KEGG	hsa04015	Rap1 signaling pathway	37/1169	210/8135	0.1058	0.2472	0.1745	ADORA2A/CSF1/KIT/FGF2/PIK3CD/PRKCA/PLCE1/SIPA1L1/VEGFA/PDGFRB/CALM1/THBS1/PIK3R2/MAPK13/PDGFD/F2R/ADCY7/PIK3R3/LPAR1/ADCY9/ADCY3/PLCB4/ENAH/PFN2/ACTB/PGF/CALM2/DOCK4/FGF5/PDGFC/RALA/FGF10/CDC42/IGF1/ACTG1/TLN1/CRKL	37
KEGG	hsa00260	Glycine, serine and threonine metabolism	9/1169	40/8135	0.1105	0.2562	0.1809	PSPH/PSAT1/GAMT/AMT/ALDH7A1/ALAS1/PHGDH/PGAM4/GNMT	9
KEGG	hsa04310	Wnt signaling pathway	30/1169	167/8135	0.112	0.258	0.1821	PPP3CC/PRKCA/NKD2/FZD1/GPC4/CAMK2D/CCND1/TCF7L2/ROR1/FZD2/WNT5B/CSNK1E/LRP5/DAAM2/PLCB4/FZD8/TBL1Y/WNT5A/CAMK2G/FZD4/RSPO2/TCF7L1/PPP3CA/LGR4/ROCK2/TLE1/DVL1/DVL2/TBL1XR1/FZD7	30
KEGG	hsa04932	Non-alcoholic fatty liver disease	28/1169	155/8135	0.1154	0.2639	0.1863	BID/IL6/IL1B/NFKB1/ERN1/IL1A/PIK3CD/SOCS3/RXRA/IRS1/FAS/ITCH/NDUFB7/PIK3R2/MAPK13/PIK3R3/ADIPOR2/NDUFS4/NDUFAB1/TRAF2/TNF/SDHD/CEBPA/PRKAB2/PPARG/CDC42/UQCRHL/CASP7	28
KEGG	hsa05170	Human immunodeficiency virus 1 infection	37/1169	212/8135	0.1171	0.2662	0.1879	NFKBIA/BID/TAP1/TAP2/PPP3CC/NFKB1/PIK3CD/PRKCA/TNFRSF1B/IRAK4/PAK1/HLA-E/APOBEC3G/HLA-F/CALM1/FAS/FADD/HLA-A/PIK3R2/GNG11/MAPK13/PXN/APOBEC3H/PIK3R3/ITPR2/GNB4/TRAF2/BCL2L1/TNF/CALM2/HLA-G/PPP3CA/APOBEC3F/TAPBP/HLA-B/CRKL/GNG2	37
KEGG	hsa04350	TGF-beta signaling pathway	18/1169	94/8135	0.1209	0.2728	0.1926	BMP2/ID2/ROCK1/BMP4/PPP2R1B/GREM2/BMPR2/THBS1/INHBB/TGFB2/GDF5/FBN1/TNF/FST/ID3/TFDP1/GDF6/SMAD9	18
KEGG	hsa04216	Ferroptosis	9/1169	41/8135	0.1245	0.2783	0.1965	SLC39A14/SLC11A2/SAT1/SLC7A11/FTH1/SLC3A2/SLC39A8/ACSL5/ATG7	9
KEGG	hsa04935	Growth hormone synthesis, secretion and action	22/1169	119/8135	0.125	0.2783	0.1965	PIK3CD/PRKCA/STAT1/SOCS1/SOCS3/IRS1/PIK3R2/MAP3K1/MAPK13/GHR/ADCY7/PIK3R3/ADCY9/ADCY3/ITPR2/PLCB4/JUNB/CACNA1F/SOCS2/IGF1/STAT3/CRKL	22
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/1169	89/8135	0.1311	0.2901	0.2048	NFKBIA/PPP3CC/NFKB1/IFNGR1/NFKBIE/PIK3CD/IFNGR2/STAT1/NFKBIB/PIK3R2/MAPK13/PIK3R3/BATF3/PPP3CA/PTPN11/TICAM1/STAT3	17
KEGG	hsa04152	AMPK signaling pathway	22/1169	120/8135	0.1334	0.2931	0.2069	PPARGC1A/PIK3CD/FOXO1/EEF2K/PPP2R1B/ACACB/IRS1/CCND1/SCD/PIK3R2/CPT1A/ACACA/PIK3R3/ADIPOR2/SIRT1/CAMKK2/PPP2R5E/PRKAB2/GYS2/PPP2R5C/PPARG/IGF1	22
KEGG	hsa00512	Mucin type O-glycan biosynthesis	8/1169	36/8135	0.1352	0.2952	0.2084	ST3GAL1/GALNT10/GALNT5/GCNT1/C1GALT1/GALNT4/GALNT11/GALNT1	8
KEGG	hsa00380	Tryptophan metabolism	9/1169	42/8135	0.1394	0.3023	0.2134	KYNU/IDO1/IL4I1/ACAT1/HADH/ACAT2/CYP1A2/AADAT/ALDH7A1	9
KEGG	hsa00100	Steroid biosynthesis	5/1169	20/8135	0.1489	0.3189	0.2251	LIPA/CYP27B1/TM7SF2/SOAT1/HSD17B7	5
KEGG	hsa00670	One carbon pool by folate	5/1169	20/8135	0.1489	0.3189	0.2251	MTHFD2L/MTHFD2/AMT/MTR/ALDH1L2	5
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	8/1169	37/8135	0.1521	0.3236	0.2284	PIK3CD/PRKCA/IRS1/PIK3R2/PIK3R3/SCNN1A/ATP1A4/IGF1	8
KEGG	hsa00640	Propanoate metabolism	7/1169	32/8135	0.1663	0.3505	0.2475	ACACB/HIBCH/BCKDHB/ACACA/ABAT/LDHB/SUCLA2	7
KEGG	hsa05226	Gastric cancer	26/1169	149/8135	0.1669	0.3505	0.2475	FGF2/PIK3CD/FZD1/RXRA/CCND1/PIK3R2/TCF7L2/E2F2/FZD2/PIK3R3/TGFB2/DDB2/WNT5B/LRP5/GADD45G/FZD8/WNT5A/ARAF/FZD4/FGF5/TCF7L1/CDKN1A/FGF10/DVL1/DVL2/FZD7	26
KEGG	hsa05340	Primary immunodeficiency	8/1169	38/8135	0.1699	0.3547	0.2504	TAP1/TAP2/IL7R/CD40/ADA/CD79A/RFX5/ORAI1	8
KEGG	hsa04130	SNARE interactions in vesicular transport	7/1169	33/8135	0.1866	0.3871	0.2732	BET1/VAMP4/STX3/STX6/STX16/VAMP7/VAMP5	7
KEGG	hsa04971	Gastric acid secretion	14/1169	76/8135	0.1952	0.4024	0.2841	PRKCA/CALM1/CAMK2D/ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/MYLK/ACTB/CAMK2G/CALM2/ATP1A4/ACTG1	14
KEGG	hsa05230	Central carbon metabolism in cancer	13/1169	70/8135	0.1981	0.406	0.2866	KIT/PIK3CD/GLS/SLC2A1/HK2/PDGFRB/IDH1/PIK3R2/PIK3R3/LDHB/PDHB/PGAM4/SIRT6	13
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/1169	22/8135	0.2	0.4073	0.2875	ACAT1/PCYOX1/ACAT2/PDSS2/IDI1	5
KEGG	hsa00650	Butanoate metabolism	6/1169	28/8135	0.2056	0.4161	0.2938	ACAT1/HADH/ACAT2/ABAT/ALDH5A1/BDH2	6
KEGG	hsa04520	Adherens junction	13/1169	71/8135	0.2128	0.4282	0.3023	LMO7/VCL/FYN/TCF7L2/SNAI2/ACTB/ACTN4/PTPRM/TCF7L1/CDC42/TJP1/ACTG1/WASF2	13
KEGG	hsa00450	Selenocompound metabolism	4/1169	17/8135	0.2201	0.4376	0.309	SEPHS1/MTR/PAPSS1/MARS2	4
KEGG	hsa00910	Nitrogen metabolism	4/1169	17/8135	0.2201	0.4376	0.309	CA12/GLUD1/CPS1/CA5B	4
KEGG	hsa04612	Antigen processing and presentation	14/1169	78/8135	0.2235	0.4416	0.3118	PSME2/TAP1/TAP2/PSME1/CTSS/HLA-E/HLA-F/HLA-A/TNF/HLA-G/HLA-DQB1/RFX5/TAPBP/HLA-B	14
KEGG	hsa00514	Other types of O-glycan biosynthesis	9/1169	47/8135	0.2261	0.4416	0.3118	B4GALT3/GALNT10/GXYLT1/GALNT5/C1GALT1/ST3GAL3/GALNT4/GALNT11/GALNT1	9
KEGG	hsa03420	Nucleotide excision repair	9/1169	47/8135	0.2261	0.4416	0.3118	RAD23B/RPA2/ERCC2/DDB2/RAD23A/GTF2H5/MNAT1/RFC2/CDK7	9
KEGG	hsa04024	cAMP signaling pathway	36/1169	221/8135	0.2303	0.4445	0.3138	NFKBIA/PLD1/NFKB1/ADORA2A/PIK3CD/PLCE1/GIP/ROCK1/PAK1/CALM1/PPP1R12A/PDE4D/CAMK2D/OXTR/PIK3R2/EDN1/PTGER2/F2R/ADCY7/PIK3R3/GRIA3/ADCY9/ADCY3/HCN4/ADORA1/CACNA1F/CAMK2G/CALM2/ATP2A2/GRIN3A/ROCK2/PDE4B/ORAI1/PDE3B/ATP1A4/NPPA	36
KEGG	hsa04660	T cell receptor signaling pathway	18/1169	104/8135	0.2312	0.4445	0.3138	NFKBIA/MAP3K8/CSF2/PPP3CC/NFKB1/NFKBIE/PIK3CD/PAK1/NFKBIB/FYN/PIK3R2/MAPK13/PIK3R3/TNF/PPP3CA/BCL10/CDC42/CBLB	18
KEGG	hsa04012	ErbB signaling pathway	15/1169	85/8135	0.2332	0.4445	0.3138	PIK3CD/PRKCA/EREG/PAK1/CAMK2D/PIK3R2/TGFA/HBEGF/PIK3R3/ARAF/CAMK2G/ABL1/CDKN1A/CBLB/CRKL	15
KEGG	hsa04925	Aldosterone synthesis and secretion	17/1169	98/8135	0.2365	0.4445	0.3138	PRKCA/CALM1/CAMK2D/ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/DAGLA/ATF1/CACNA1F/CAMK2G/CALM2/DAGLB/ORAI1/ATP1A4/NPPA	17
KEGG	hsa05231	Choline metabolism in cancer	17/1169	98/8135	0.2365	0.4445	0.3138	PLD1/PIK3CD/PRKCA/SLC22A2/PLA2G4A/SLC22A1/PDGFRB/SLC22A4/PLA2G4C/PIK3R2/PDGFD/PIK3R3/DGKI/PDGFC/SLC22A3/CHKB/WASF2	17
KEGG	hsa05168	Herpes simplex virus 1 infection	77/1169	495/8135	0.2368	0.4445	0.3138	NFKBIA/BIRC3/BID/CCL5/IL6/IL1B/TAP1/TAP2/NFKB1/IRF9/CCL2/OAS1/IFIH1/IFNAR2/IFNGR1/IFNAR1/BIRC2/PIK3CD/OAS3/DAXX/TNFRSF14/IFNGR2/C3/STAT1/IRAK4/IRF7/TRAF3/HLA-E/IL12A/SOCS3/ZFP90/POU2F2/HLA-F/ZNF684/OAS2/DDX58/FAS/FADD/HLA-A/PIK3R2/EIF2AK4/ZNF30/NXF1/PIK3R3/STAT2/ZNF441/ZNF529/TRAF2/BCL2L1/ZNF426/ZNF436/TYK2/ZNF74/ZNF91/ZNF558/TNF/ZNF701/ZNF320/EIF2B5/EIF2B4/SP100/ZNF33A/TLR3/HLA-G/HLA-DQB1/ZNF791/ZNF135/PTPN11/TAPBP/TICAM1/ZNF540/ZNF83/HLA-B/ZNF484/HCFC2/ZNF675/ZNF184	77
KEGG	hsa04730	Long-term depression	11/1169	60/8135	0.2369	0.4445	0.3138	PRKCA/PLA2G4A/PPP2R1B/PLA2G4C/GRIA3/GNA13/GNA12/ITPR2/PLCB4/ARAF/IGF1	11
KEGG	hsa05210	Colorectal cancer	15/1169	86/8135	0.2476	0.462	0.3261	PIK3CD/EREG/CCND1/PIK3R2/TCF7L2/TGFA/PMAIP1/PIK3R3/TGFB2/DDB2/GADD45G/ARAF/TCF7L1/RALA/CDKN1A	15
KEGG	hsa04640	Hematopoietic cell lineage	17/1169	99/8135	0.25	0.4639	0.3275	IL6/CSF2/IL1B/ITGA1/IL1A/CSF1/KIT/ANPEP/IL7R/IL4R/CD44/ITGA4/ITGA2/TNF/IL11RA/HLA-DQB1/ITGA6	17
KEGG	hsa00500	Starch and sucrose metabolism	7/1169	36/8135	0.2528	0.4639	0.3275	PYGL/HK2/UGP2/PGM2L1/ENPP1/GYG1/GYS2	7
KEGG	hsa00061	Fatty acid biosynthesis	4/1169	18/8135	0.2532	0.4639	0.3275	ACACB/ACACA/ACSL5/CBR4	4
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/1169	30/8135	0.2553	0.4639	0.3275	ACO1/IDH1/FH/PDHB/SDHD/SUCLA2	6
KEGG	hsa05203	Viral carcinogenesis	33/1169	204/8135	0.2555	0.4639	0.3275	NFKBIA/NFKB1/IRF9/NFKB2/CDK6/PIK3CD/C3/IL6ST/IRF7/TRAF3/HLA-E/HLA-F/CCND1/HLA-A/PIK3R2/PXN/PMAIP1/MAD1L1/PIK3R3/KAT2B/CHD4/POLB/TRAF2/GSN/YWHAH/ACTN4/SP100/HLA-G/CDKN1A/CDC42/STAT3/HLA-B/UBR4	33
KEGG	hsa04145	Phagosome	25/1169	152/8135	0.2622	0.4733	0.3342	OLR1/TAP1/TAP2/TUBB3/THBS2/C3/ATP6V1E2/CTSS/HLA-E/HLA-F/ATP6V0B/SEC61G/ITGB5/ATP6V0E2/CYBA/THBS1/HLA-A/ITGA2/ACTB/HLA-G/HLA-DQB1/M6PR/ACTG1/HLA-B/ATP6V1E1	25
KEGG	hsa00565	Ether lipid metabolism	9/1169	49/8135	0.2654	0.4767	0.3365	PLD1/PLA2G4A/TMEM189/TMEM189-UBE2V1/PLA2G4C/PLA2G12A/PAFAH1B2/UGT8/PLD3	9
KEGG	hsa01250	Biosynthesis of nucleotide sugars	7/1169	37/8135	0.2763	0.4936	0.3484	GFPT2/HK2/UGP2/NAGK/GMDS/GMPPB/PGM3	7
KEGG	hsa00052	Galactose metabolism	6/1169	31/8135	0.2813	0.4997	0.3528	AKR1B1/HK2/GALM/UGP2/GLA/GLB1	6
KEGG	hsa00510	N-Glycan biosynthesis	9/1169	50/8135	0.2859	0.5022	0.3545	MAN1A1/B4GALT3/MAN1C1/MOGS/MGAT1/MGAT2/ALG3/DAD1/ALG13	9
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	73/1169	476/8135	0.2872	0.5022	0.3545	BID/PTGS2/IL6/IL1B/PPP3CC/TUBB3/NFKB1/PSMA6/ERN1/IL1A/CSF1/SQSTM1/UBE2L6/PRKCA/DAXX/PSMB7/TNFRSF1B/FZD1/PPIF/CALM1/CAMK2D/FAS/PSMA3/FADD/WIPI1/NDUFB7/UBA7/MAPK13/FZD2/DCTN1/GRIA3/WNT5B/NDUFS4/CSNK1E/LRP5/PSMA1/ITPR2/PLCB4/FZD8/PSMB2/CDK5/NDUFAB1/OPTN/WNT5A/TRAF2/ARAF/BCL2L1/PSMB3/TNF/CACNA1F/CACNA1B/CAMK2G/CALM2/ACTR10/ATP2A2/SDHD/FZD4/DLG4/PRPH/PSMA8/PPP3CA/VDAC1/UBB/SIGMAR1/PSMB5/DCTN3/DVL1/DVL2/FZD7/UQCRHL/CASP7/CAPN2/DNAH6	73
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1169	19/8135	0.2872	0.5022	0.3545	ACO1/IDH1/AADAT/BCAT2	4
KEGG	hsa00230	Purine metabolism	21/1169	128/8135	0.2892	0.5031	0.3552	PRPS1/PDE1C/PRPS1L1/PDE4D/AK1/PDE1A/AMPD3/ADA/NT5C2/ENPP1/ADCY7/ADCY9/ADCY3/IMPDH2/PAPSS1/GUK1/NPR2/PDE4B/PDE3B/PDE5A/DCK	21
KEGG	hsa04727	GABAergic synapse	15/1169	89/8135	0.2928	0.5067	0.3577	PRKCA/GLS/GABARAPL1/SLC38A2/GNG11/ADCY7/ADCY9/ADCY3/GNB4/ABAT/CACNA1F/CACNA1B/GABRA3/SLC38A1/GNG2	15
KEGG	hsa04917	Prolactin signaling pathway	12/1169	70/8135	0.3005	0.5173	0.3652	NFKB1/IRF1/PIK3CD/STAT1/SOCS1/SOCS3/CCND1/PIK3R2/MAPK13/PIK3R3/SOCS2/STAT3	12
KEGG	hsa04926	Relaxin signaling pathway	21/1169	129/8135	0.3021	0.5175	0.3653	NFKBIA/MMP1/NFKB1/PIK3CD/PRKCA/VEGFA/COL1A1/PIK3R2/GNG11/EDN1/MAPK13/ADCY7/PIK3R3/ADCY9/ADCY3/MMP9/PLCB4/GNB4/COL4A1/COL1A2/GNG2	21
KEGG	hsa00270	Cysteine and methionine metabolism	9/1169	51/8135	0.3067	0.5199	0.367	MAT2A/IL4I1/PSAT1/MTR/LDHB/BHMT2/PHGDH/MTAP/BCAT2	9
KEGG	hsa04913	Ovarian steroidogenesis	9/1169	51/8135	0.3067	0.5199	0.367	PTGS2/PLA2G4A/PLA2G4C/ADCY7/ADCY9/ADCY3/HSD17B7/IGF1/CYP19A1	9
KEGG	hsa04150	mTOR signaling pathway	25/1169	156/8135	0.3085	0.5204	0.3674	LPIN1/PIK3CD/PRKCA/ATP6V1E2/FZD1/IRS1/FNIP2/SLC3A2/PIK3R2/FNIP1/FZD2/PIK3R3/WNT5B/LRP5/FZD8/WNT5A/SESN2/TNF/FZD4/IGF1/DVL1/DVL2/FZD7/ATP6V1E1/PRR5	25
KEGG	hsa05017	Spinocerebellar ataxia	23/1169	143/8135	0.3119	0.5235	0.3695	PSMA6/ERN1/PIK3CD/PRKCA/PSMB7/PPIF/PSMA3/WIPI1/PIK3R2/PIK3R3/GRIA3/PSMA1/ITPR2/PLCB4/PSMB2/TRAF2/PSMB3/ATP2A2/PSMA8/GRIN3A/VDAC1/KCND3/PSMB5	23
KEGG	hsa03022	Basal transcription factors	8/1169	45/8135	0.3155	0.5268	0.3719	ERCC2/TAF13/TAF7L/GTF2H5/TAF6L/MNAT1/GTF2F2/CDK7	8
KEGG	hsa05213	Endometrial cancer	10/1169	58/8135	0.3181	0.5286	0.3732	PIK3CD/CCND1/PIK3R2/TCF7L2/PIK3R3/DDB2/GADD45G/ARAF/TCF7L1/CDKN1A	10
KEGG	hsa05032	Morphine addiction	15/1169	91/8135	0.3242	0.5361	0.3784	PRKCA/PDE1C/PDE4D/PDE1A/GNG11/ADCY7/ADCY9/ADCY3/GNB4/ADORA1/CACNA1B/GABRA3/PDE4B/PDE3B/GNG2	15
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1169	14/8135	0.3262	0.5367	0.3789	ST3GAL1/B4GALT3/ST3GAL3	3
KEGG	hsa01522	Endocrine resistance	16/1169	98/8135	0.3306	0.5413	0.3821	PIK3CD/CCND1/PIK3R2/MAPK13/E2F2/HBEGF/ADCY7/PIK3R3/ADCY9/ADCY3/MMP9/CARM1/CDKN2C/ARAF/CDKN1A/IGF1	16
KEGG	hsa00051	Fructose and mannose metabolism	6/1169	33/8135	0.3347	0.5454	0.385	AKR1B1/HK2/GMDS/GMPPB/ENOSF1/ALDOC	6
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1169	27/8135	0.3453	0.5599	0.3953	ST8SIA1/B4GALT3/A4GALT/ST3GAL3/ST3GAL4	5
KEGG	hsa00010	Glycolysis / Gluconeogenesis	11/1169	67/8135	0.3662	0.5909	0.4172	HK2/GALM/ENO2/ADPGK/ADH5/ALDH7A1/LDHB/PDHB/PGAM4/ADH1C/ALDOC	11
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1169	15/8135	0.3682	0.5913	0.4174	ST3GAL1/ST8SIA1/GLB1	3
KEGG	hsa00561	Glycerolipid metabolism	10/1169	61/8135	0.3788	0.6054	0.4274	AKR1B1/GK/LPIN1/GLA/LIPG/ALDH7A1/DGKI/GPAM/PNLIPRP3/LCLAT1	10
KEGG	hsa00830	Retinol metabolism	11/1169	68/8135	0.3856	0.6134	0.433	ALDH1A3/CYP27C1/RDH10/RDH8/DHRS3/ADH5/CYP1A2/HSD17B6/RDH13/ADH1C/CYP2S1	11
KEGG	hsa00220	Arginine biosynthesis	4/1169	22/8135	0.3914	0.6195	0.4373	GLS/GLUD1/ASS1/CPS1	4
KEGG	hsa00591	Linoleic acid metabolism	5/1169	29/8135	0.4061	0.6361	0.4491	PLA2G4A/PLA2G4C/CYP1A2/PLA2G12A/CYP2C19	5
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1169	49/8135	0.4076	0.6361	0.4491	GFPT2/HK2/UGP2/NAGK/GMDS/GMPPB/CYB5R2/PGM3	8
KEGG	hsa04672	Intestinal immune network for IgA production	8/1169	49/8135	0.4076	0.6361	0.4491	IL6/TNFSF13B/CD40/IL15RA/ITGA4/IL15/HLA-DQB1/CCR10	8
KEGG	hsa00430	Taurine and hypotaurine metabolism	3/1169	16/8135	0.4097	0.6365	0.4493	FMO5/ADO/FMO4	3
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	6/1169	36/8135	0.4165	0.6441	0.4547	NAMPT/NNMT/NT5C2/ENPP1/SIRT1/SIRT6	6
KEGG	hsa04114	Oocyte meiosis	20/1169	131/8135	0.4217	0.6469	0.4567	PPP3CC/PPP2R1B/CALM1/CAMK2D/CDC16/MAPK13/MAD1L1/ADCY7/ADCY9/ADCY3/ITPR2/ANAPC13/CAMK2G/YWHAH/PPP2R5E/CALM2/PPP3CA/PPP2R5C/CDC23/IGF1	20
KEGG	hsa04713	Circadian entrainment	15/1169	97/8135	0.4222	0.6469	0.4567	PRKCA/CALM1/CAMK2D/RASD1/GNG11/ADCY7/GRIA3/ADCY9/ADCY3/PLCB4/GNB4/CAMK2G/CALM2/PER1/GNG2	15
KEGG	hsa05206	MicroRNAs in cancer	46/1169	310/8135	0.4306	0.654	0.4617	PTGS2/NFKB1/CDK6/FSCN1/RECK/PIK3CD/PRKCA/GLS/VEGFA/ROCK1/PDGFRB/SOCS1/PLAU/BCL2L2/CD44/MIR193B/IRS1/BMPR2/CCND1/CDC25A/THBS1/PIM1/PIK3R2/RDX/E2F2/PIK3R3/TGFB2/ABCC1/MMP9/SIRT1/MIR19B2/TP63/MIR137/TNC/MIR423/CCNG1/MIR1-2/MIR125B1/ABL1/MIR214/MIR330/CDKN1A/RASSF1/MIR199A2/STAT3/CRKL	46
KEGG	hsa04979	Cholesterol metabolism	8/1169	50/8135	0.4308	0.654	0.4617	ABCA1/LIPA/SORT1/LIPG/SOAT1/OSBPL5/VDAC1/MYLIP	8
KEGG	hsa04142	Lysosome	20/1169	132/8135	0.436	0.6589	0.4651	SLC11A2/NCOA7/CTSS/LIPA/ATP6V0B/SORT1/GNPTAB/WDR7/NAGA/GLA/GLB1/PPT1/CLTC/IGF2R/AGA/DMXL1/MCOLN1/AP3S1/M6PR/CD164	20
KEGG	hsa04929	GnRH secretion	10/1169	64/8135	0.4404	0.6625	0.4677	KCNN4/PIK3CD/PRKCA/PIK3R2/TRPC1/PIK3R3/ITPR2/PLCB4/CACNA1F/KISS1R	10
KEGG	hsa04725	Cholinergic synapse	17/1169	113/8135	0.4594	0.6881	0.4858	PIK3CD/PRKCA/FYN/CAMK2D/PIK3R2/GNG11/ADCY7/PIK3R3/ADCY9/ADCY3/ITPR2/PLCB4/GNB4/CACNA1F/CACNA1B/CAMK2G/GNG2	17
KEGG	hsa05415	Diabetic cardiomyopathy	30/1169	203/8135	0.4644	0.6887	0.4862	GFPT2/NFKB1/PIK3CD/PRKCA/SLC2A1/COL1A1/PPIF/IRS1/CAMK2D/TBC1D4/CYBA/NDUFB7/PIK3R2/MAPK13/PIK3R3/TGFB2/NDUFS4/MMP9/PLCB4/NDUFAB1/CAMK2G/PDHB/ATP2A2/SDHD/PRKCD/GYS2/PDK3/COL1A2/VDAC1/UQCRHL	30
KEGG	hsa00410	beta-Alanine metabolism	5/1169	31/8135	0.466	0.6887	0.4862	HIBCH/SMOX/ALDH7A1/ABAT/CNDP2	5
KEGG	hsa04710	Circadian rhythm	5/1169	31/8135	0.466	0.6887	0.4862	NPAS2/ARNTL/CSNK1E/PRKAB2/PER1	5
KEGG	hsa04911	Insulin secretion	13/1169	86/8135	0.4681	0.6888	0.4863	KCNN4/PRKCA/SLC2A1/GIP/CAMK2D/ADCY7/ADCY9/ADCY3/PLCB4/RAB3A/CACNA1F/CAMK2G/ATP1A4	13
KEGG	hsa04330	Notch signaling pathway	9/1169	59/8135	0.4791	0.7019	0.4955	KAT2B/APH1B/PSENEN/HES5/NUMBL/NCOR2/TLE1/DVL1/DVL2	9
KEGG	hsa00562	Inositol phosphate metabolism	11/1169	73/8135	0.4829	0.7043	0.4972	PLCD3/PIK3CD/PLCE1/PLCD1/IMPA2/PLCB4/ITPKA/INPP5B/PIP4K2A/INPP1/PI4K2B	11
KEGG	hsa04726	Serotonergic synapse	17/1169	115/8135	0.4903	0.712	0.5026	PTGS2/PRKCA/PLA2G4A/PLA2G4C/GNG11/TRPC1/ITPR2/PLCB4/HTR3B/GNB4/ARAF/CACNA1F/CACNA1B/PTGS1/CYP2C19/GNG2/CYP4X1	17
KEGG	hsa05320	Autoimmune thyroid disease	8/1169	53/8135	0.4995	0.7202	0.5084	HLA-E/HLA-F/CD40/FAS/HLA-A/HLA-G/HLA-DQB1/HLA-B	8
KEGG	hsa04720	Long-term potentiation	10/1169	67/8135	0.5013	0.7202	0.5084	PPP3CC/PRKCA/CALM1/CAMK2D/ITPR2/PLCB4/ARAF/CAMK2G/CALM2/PPP3CA	10
KEGG	hsa04540	Gap junction	13/1169	88/8135	0.5034	0.7202	0.5084	TUBB3/PRKCA/PDGFRB/PDGFD/ADCY7/LPAR1/ADCY9/ADCY3/ITPR2/PLCB4/MAP3K2/PDGFC/TJP1	13
KEGG	hsa04914	Progesterone-mediated oocyte maturation	15/1169	102/8135	0.5046	0.7202	0.5084	PIK3CD/CDC16/CDC25A/PIK3R2/MAPK13/MAD1L1/ADCY7/PIK3R3/ADCY9/ADCY3/ARAF/ANAPC13/PDE3B/CDC23/IGF1	15
KEGG	hsa04662	B cell receptor signaling pathway	12/1169	82/8135	0.5209	0.7318	0.5167	NFKBIA/PPP3CC/NFKB1/NFKBIE/PIK3CD/IFITM1/NFKBIB/PIK3R2/PIK3R3/CD79A/PPP3CA/BCL10	12
KEGG	hsa04664	Fc epsilon RI signaling pathway	10/1169	68/8135	0.5212	0.7318	0.5167	CSF2/PIK3CD/PRKCA/PLA2G4A/FYN/PLA2G4C/PIK3R2/MAPK13/PIK3R3/TNF	10
KEGG	hsa00140	Steroid hormone biosynthesis	9/1169	61/8135	0.5215	0.7318	0.5167	HSD11B1/DHRS11/SRD5A1/CYP1A2/HSD17B12/HSD17B7/HSD17B6/CYP19A1/SULT2B1	9
KEGG	hsa00590	Arachidonic acid metabolism	9/1169	61/8135	0.5215	0.7318	0.5167	PTGS2/CBR3/PTGES/PLA2G4A/PLA2G4C/CYP2U1/PLA2G12A/PTGS1/CYP2C19	9
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1169	26/8135	0.5255	0.7343	0.5184	PIGV/MPPE1/PIGK/PIGS	4
KEGG	hsa01240	Biosynthesis of cofactors	22/1169	153/8135	0.5345	0.7418	0.5237	KYNU/MTHFD2L/IDO1/MAT2A/UGP2/CMPK2/AK1/GMPPB/GCH1/DHRS3/MTHFD2/PNPO/PSAT1/COQ3/PPCS/RGN/ALAS1/HSD17B6/PDXP/RDH13/PTS/BCAT2	22
KEGG	hsa04728	Dopaminergic synapse	19/1169	132/8135	0.5352	0.7418	0.5237	PPP3CC/PRKCA/PPP2R1B/CALM1/CAMK2D/GNG11/MAPK13/ARNTL/GRIA3/ITPR2/PLCB4/GNB4/CACNA1B/CAMK2G/PPP2R5E/CALM2/PPP3CA/PPP2R5C/GNG2	19
KEGG	hsa05031	Amphetamine addiction	10/1169	69/8135	0.5409	0.7466	0.527	PPP3CC/PRKCA/CALM1/CAMK2D/GRIA3/SIRT1/CAMK2G/CALM2/PPP3CA/GRIN3A	10
KEGG	hsa04110	Cell cycle	18/1169	126/8135	0.5501	0.7561	0.5338	CDK6/CCND1/CDC16/CDC25A/E2F2/MAD1L1/CDC14B/TGFB2/GADD45G/CDKN2C/ANAPC13/CDKN1C/YWHAH/ABL1/CDKN1A/TFDP1/CDC23/CDK7	18
KEGG	hsa00310	Lysine degradation	9/1169	63/8135	0.5626	0.769	0.5429	ACAT1/HADH/ACAT2/SMYD3/AADAT/PLOD2/SETDB2/ALDH7A1/SETMAR	9
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1169	20/8135	0.5641	0.769	0.5429	CHST7/CSGALNACT1/CSGALNACT2	3
KEGG	hsa03450	Non-homologous end-joining	2/1169	13/8135	0.5768	0.7831	0.5528	XRCC4/FEN1	2
KEGG	hsa04970	Salivary secretion	13/1169	93/8135	0.5885	0.7959	0.5618	KCNN4/PRKCA/CALM1/SLC12A2/ADCY7/DMBT1/ADCY9/ADCY3/ITPR2/PLCB4/CALM2/ADRB3/ATP1A4	13
KEGG	hsa03018	RNA degradation	11/1169	79/8135	0.5944	0.8005	0.5651	BTG3/TTC37/ENO2/EXOSC6/DCP1A/PABPC1/DIS3L/BTG2/CNOT8/LSM6/PATL1	11
KEGG	hsa00770	Pantothenate and CoA biosynthesis	3/1169	21/8135	0.5987	0.8031	0.5669	ENPP1/PPCS/BCAT2	3
KEGG	hsa04915	Estrogen signaling pathway	19/1169	138/8135	0.6179	0.8255	0.5828	PIK3CD/KRT14/CALM1/PIK3R2/KRT16/TGFA/HBEGF/ADCY7/PIK3R3/ADCY9/ADCY3/MMP9/KRT24/ITPR2/PLCB4/CALM2/KRT19/PRKCD/TFF1	19
KEGG	hsa04962	Vasopressin-regulated water reabsorption	6/1169	44/8135	0.6209	0.8262	0.5832	DYNC2LI1/DCTN1/ADCY9/ADCY3/DYNLL1/ARHGDIB	6
KEGG	hsa04371	Apelin signaling pathway	19/1169	139/8135	0.631	0.8336	0.5885	PPARGC1A/KLF2/CALM1/CCND1/GNG11/ADCY7/GNA13/ADCY9/ADCY3/ITPR2/PLCB4/MEF2C/GNB4/MYLK/CALM2/PRKAB2/SERPINE1/PDE3B/GNG2	19
KEGG	hsa00340	Histidine metabolism	3/1169	22/8135	0.6314	0.8336	0.5885	HNMT/ALDH7A1/CNDP2	3
KEGG	hsa00030	Pentose phosphate pathway	4/1169	30/8135	0.6436	0.8429	0.5951	PRPS1/PRPS1L1/RGN/ALDOC	4
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1169	30/8135	0.6436	0.8429	0.5951	ACO1/ACAT1/ACAT2/AMT	4
KEGG	hsa04723	Retrograde endocannabinoid signaling	20/1169	148/8135	0.6536	0.8514	0.6011	PTGS2/PRKCA/NDUFB7/GNG11/MAPK13/ADCY7/GRIA3/NDUFS4/ADCY9/ADCY3/ITPR2/PLCB4/DAGLA/GNB4/NDUFAB1/CACNA1F/CACNA1B/DAGLB/GABRA3/GNG2	20
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1169	53/8135	0.6551	0.8514	0.6011	BDKRB2/PRKCA/CLTC/ADCY9/PLCB4/VDR/ATP1A4	7
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/1169	23/8135	0.6623	0.854	0.6029	B4GALT3/POMGNT1/ST3GAL3	3
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	3/1169	23/8135	0.6623	0.854	0.6029	GLS/GLUD1/ATP1A4	3
KEGG	hsa04141	Protein processing in endoplasmic reticulum	23/1169	171/8135	0.6687	0.859	0.6064	ERN1/BAG2/MAN1A1/PPP1R15A/DNAJA1/RAD23B/SEC61G/HERPUD1/MAN1C1/EIF2AK4/CRYAB/DNAJC3/MOGS/RNF5/TRAF2/RAD23A/UBXN1/SSR2/HYOU1/SSR1/DAD1/UBE4B/CAPN2	23
KEGG	hsa04973	Carbohydrate digestion and absorption	6/1169	47/8135	0.6861	0.8775	0.6194	PIK3CD/HK2/PIK3R2/PIK3R3/PLCB4/ATP1A4	6
KEGG	hsa04977	Vitamin digestion and absorption	3/1169	24/8135	0.6912	0.8775	0.6194	SLC19A3/ABCC1/SLC19A1	3
KEGG	hsa01232	Nucleotide metabolism	11/1169	85/8135	0.6936	0.8775	0.6194	TYMP/CMPK2/AK1/AMPD3/ADA/NT5C2/ENPP1/IMPDH2/GUK1/TK2/DCK	11
KEGG	hsa04610	Complement and coagulation cascades	11/1169	85/8135	0.6936	0.8775	0.6194	BDKRB1/BDKRB2/SERPINB2/C3/PLAU/VWF/F2R/CFB/SERPINE1/SERPINA1/SERPINF2	11
KEGG	hsa04721	Synaptic vesicle cycle	10/1169	78/8135	0.7008	0.8833	0.6236	ATP6V1E2/ATP6V0B/STX3/ATP6V0E2/CLTC/RAB3A/CACNA1B/STXBP1/SYT1/ATP6V1E1	10
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	28/1169	212/8135	0.7167	0.8936	0.6308	NFKB1/FGF2/PIK3CD/PRKCA/AHR/VEGFA/GSTO1/RXRA/GSTA4/CCND1/KLF4/CDC25A/PIK3R2/ADCY7/PIK3R3/CYP1A2/ADCY9/KPNA3/ADCY3/VDR/CACNA1F/CACNA1B/FGF5/ADRB3/KPNA2/FGF10/MGST2/STAT3	28
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1169	25/8135	0.7182	0.8936	0.6308	PLA2G4A/PLA2G4C/PLA2G12A	3
KEGG	hsa03410	Base excision repair	4/1169	33/8135	0.7184	0.8936	0.6308	POLB/FEN1/MBD4/NEIL3	4
KEGG	hsa04972	Pancreatic secretion	13/1169	102/8135	0.7229	0.8936	0.6308	PRKCA/SLC12A2/TRPC1/ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/PLA2G12A/ATP2A2/SLC26A3/ATP1A4/CLCA1	13
KEGG	hsa00982	Drug metabolism - cytochrome P450	9/1169	72/8135	0.725	0.8936	0.6308	GSTO1/GSTA4/ADH5/CYP1A2/FMO5/ADH1C/MGST2/FMO4/CYP2C19	9
KEGG	hsa04137	Mitophagy - animal	9/1169	72/8135	0.725	0.8936	0.6308	CITED2/SQSTM1/GABARAPL1/MITF/OPTN/BCL2L1/TFE3/TAX1BP1/UBB	9
KEGG	hsa03020	RNA polymerase	4/1169	34/8135	0.7405	0.9093	0.642	POLR3GL/POLR3D/POLR3K/POLR1C	4
KEGG	hsa00790	Folate biosynthesis	3/1169	26/8135	0.7433	0.9094	0.642	AKR1B1/GCH1/PTS	3
KEGG	hsa00480	Glutathione metabolism	7/1169	58/8135	0.7469	0.9105	0.6428	ANPEP/GSTO1/LANCL1/GSTA4/IDH1/CHAC2/MGST2	7
KEGG	hsa00511	Other glycan degradation	2/1169	18/8135	0.754	0.9142	0.6454	GLB1/AGA	2
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	19/1169	150/8135	0.7594	0.9142	0.6454	PRKCA/PPP2R1B/CALM1/CAMK2D/ACTC1/MAPK13/ADCY7/ADCY9/ADCY3/PLCB4/TPM4/CACNA1F/CAMK2G/PPP2R5E/CALM2/ATP2A2/PPP2R5C/ATP1A4/MYH6	19
KEGG	hsa04975	Fat digestion and absorption	5/1169	43/8135	0.7601	0.9142	0.6454	ABCA1/ACAT1/ACAT2/NPC1L1/PLA2G12A	5
KEGG	hsa00330	Arginine and proline metabolism	6/1169	51/8135	0.761	0.9142	0.6454	SAT1/SMOX/P4HA2/GAMT/ALDH7A1/CNDP2	6
KEGG	hsa04966	Collecting duct acid secretion	3/1169	27/8135	0.7667	0.9164	0.647	ATP6V1E2/ATP6V0E2/ATP6V1E1	3
KEGG	hsa00564	Glycerophospholipid metabolism	12/1169	98/8135	0.7683	0.9164	0.647	PLD1/LPIN1/GPD1L/PLA2G4A/PISD/PLA2G4C/PLA2G12A/DGKI/GPAM/CHKB/LCLAT1/PLD3	12
KEGG	hsa00350	Tyrosine metabolism	4/1169	36/8135	0.7809	0.9249	0.6529	IL4I1/FAH/ADH5/ADH1C	4
KEGG	hsa03030	DNA replication	4/1169	36/8135	0.7809	0.9249	0.6529	RPA2/PRIM2/FEN1/RFC2	4
KEGG	hsa00920	Sulfur metabolism	1/1169	10/8135	0.7882	0.9303	0.6567	PAPSS1	1
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1169	78/8135	0.808	0.9502	0.6708	CBR3/HSD11B1/GSTO1/GSTA4/ADH5/CYP1A2/ADH1C/MGST2/CYP2S1	9
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1169	11/8135	0.8187	0.9595	0.6773	COQ3	1
KEGG	hsa04974	Protein digestion and absorption	12/1169	103/8135	0.8238	0.962	0.6792	KCNN4/SLC38A2/COL1A1/SLC3A2/COL5A2/COL6A3/COL16A1/COL4A1/COL24A1/COL1A2/ATP1A4/COL5A1	12
KEGG	hsa04976	Bile secretion	10/1169	89/8135	0.8416	0.9682	0.6835	SLC2A1/AQP9/SLC22A1/RXRA/ADCY7/ADCY9/ADCY3/ABCC2/ABCG2/ATP1A4	10
KEGG	hsa05020	Prion disease	34/1169	273/8135	0.8429	0.9682	0.6835	CCL5/IL6/IL1B/PPP3CC/TUBB3/PSMA6/IL1A/PIK3CD/PSMB7/PPIF/FYN/PSMA3/CYBA/NDUFB7/PIK3R2/MAPK13/PIK3R3/NDUFS4/PSMA1/ITPR2/PSMB2/NDUFAB1/PSMB3/TNF/CACNA1F/CACNA1B/SDHD/PRKCD/PSMA8/PPP3CA/GRIN3A/VDAC1/PSMB5/UQCRHL	34
KEGG	hsa05310	Asthma	3/1169	31/8135	0.8432	0.9682	0.6835	CD40/TNF/HLA-DQB1	3
KEGG	hsa04927	Cortisol synthesis and secretion	7/1169	65/8135	0.8441	0.9682	0.6835	ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/CACNA1F/ORAI1	7
KEGG	hsa05012	Parkinson disease	33/1169	266/8135	0.8458	0.9682	0.6835	SLC39A14/SLC11A2/TUBB3/PSMA6/ERN1/ADORA2A/UBE2L6/DAXX/PSMB7/PPIF/CALM1/CAMK2D/PSMA3/SLC39A10/NDUFB7/UBA7/SLC39A8/NDUFS4/PSMA1/ITPR2/PSMB2/NDUFAB1/BCL2L1/PSMB3/TXN/CAMK2G/CALM2/SDHD/PSMA8/VDAC1/UBB/PSMB5/UQCRHL	33
KEGG	hsa05033	Nicotine addiction	4/1169	40/8135	0.8465	0.9682	0.6835	GRIA3/CACNA1B/GABRA3/GRIN3A	4
KEGG	hsa05030	Cocaine addiction	5/1169	49/8135	0.8522	0.9708	0.6854	NFKB1/CDK5/DLG4/GRM2/GRIN3A	5
KEGG	hsa04136	Autophagy - other	3/1169	32/8135	0.8585	0.9708	0.6854	GABARAPL1/WIPI1/ATG7	3
KEGG	hsa00240	Pyrimidine metabolism	6/1169	58/8135	0.8588	0.9708	0.6854	TYMP/CMPK2/NT5C2/ENPP1/TK2/DCK	6
KEGG	hsa04918	Thyroid hormone synthesis	8/1169	75/8135	0.863	0.9708	0.6854	PRKCA/TTF2/ADCY7/ADCY9/ADCY3/ITPR2/PLCB4/ATP1A4	8
KEGG	hsa03430	Mismatch repair	2/1169	23/8135	0.8633	0.9708	0.6854	RPA2/RFC2	2
KEGG	hsa03013	Nucleocytoplasmic transport	12/1169	108/8135	0.8687	0.9736	0.6873	NUP133/NXF1/KPNA3/ACIN1/SUMO3/NXT1/KPNA2/RANBP17/NUP35/TMEM33/XPO7/DDX19A	12
KEGG	hsa04140	Autophagy - animal	16/1169	141/8135	0.878	0.9749	0.6882	ERN1/SQSTM1/PIK3CD/DAPK1/GABARAPL1/TP53INP2/CFLAR/IRS1/WIPI1/PIK3R2/EIF2AK4/PIK3R3/ATG7/BCL2L1/CAMKK2/PRKCD	16
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1169	24/8135	0.8789	0.9749	0.6882	EXT1/HS2ST1	2
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	7/1169	69/8135	0.8846	0.9749	0.6882	PTGS2/HSD11B1/GSTO1/GSTA4/CYP1A2/MGST2/CYP2C19	7
KEGG	hsa00040	Pentose and glucuronate interconversions	3/1169	34/8135	0.8853	0.9749	0.6882	AKR1B1/UGP2/CRYL1	3
KEGG	hsa00600	Sphingolipid metabolism	5/1169	52/8135	0.8859	0.9749	0.6882	UGCG/GLA/GLB1/UGT8/SGMS2	5
KEGG	hsa04742	Taste transduction	9/1169	86/8135	0.8873	0.9749	0.6882	PDE1C/PDE1A/HCN4/PLCB4/HTR3B/P2RX3/GABRA3/SCNN1A/TAS2R16	9
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/1169	223/8135	0.9001	0.9834	0.6942	SOD2/NFKBIA/PLD1/NFKB1/PIK3CD/AHR/VEGFA/GSTO1/PPIF/GSTA4/CYBA/NDUFB7/PIK3R2/MAPK13/PIK3R3/CYP1A2/NDUFS4/NDUFAB1/ARAF/SDHD/PRKCD/ABL1/VDAC1/PTPN11/MGST2/UQCRHL	26
KEGG	hsa00730	Thiamine metabolism	1/1169	15/8135	0.9026	0.9834	0.6942	AK1	1
KEGG	hsa04950	Maturity onset diabetes of the young	2/1169	26/8135	0.9054	0.9834	0.6942	NEUROG3/IAPP	2
KEGG	hsa03015	mRNA surveillance pathway	10/1169	97/8135	0.9068	0.9834	0.6942	PPP2R1B/CPSF2/NXF1/ACIN1/CPSF6/PABPC1/PPP2R5E/PPP2R5C/NXT1/DDX19A	10
KEGG	hsa00360	Phenylalanine metabolism	1/1169	16/8135	0.9166	0.9908	0.6995	IL4I1	1
KEGG	hsa04340	Hedgehog signaling pathway	5/1169	56/8135	0.9204	0.9917	0.7001	CCND1/CSNK1G2/CSNK1E/GPR161/CSNK1G3	5
KEGG	hsa04744	Phototransduction	2/1169	29/8135	0.9351	1	0.706	CALM1/CALM2	2
KEGG	hsa04714	Thermogenesis	26/1169	232/8135	0.9356	1	0.706	PPARGC1A/COX11/NDUFB7/SMARCD3/MAPK13/COX17/ADCY7/CPT1A/ACSL5/NDUFS4/ADCY9/ADCY3/SMARCA2/NDUFAB1/ACTB/SLC25A20/SDHD/ADRB3/PRKAB2/ARID1A/SMARCE1/PPARG/NPPA/ACTG1/UQCRHL/SIRT6	26
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/1169	30/8135	0.9428	1	0.706	RGN/ALDH7A1	2
KEGG	hsa00531	Glycosaminoglycan degradation	1/1169	19/8135	0.9477	1	0.706	GLB1	1
KEGG	hsa00983	Drug metabolism - other enzymes	7/1169	80/8135	0.9533	1	0.706	TYMP/GSTO1/GSTA4/IMPDH2/TK2/MGST2/TPMT	7
KEGG	hsa05014	Amyotrophic lateral sclerosis	42/1169	364/8135	0.954	1	0.706	BID/PPP3CC/TUBB3/PSMA6/ERN1/SQSTM1/DAXX/PSMB7/TNFRSF1B/ANXA11/NUP133/PSMA3/WIPI1/NDUFB7/MAPK13/NXF1/DCTN1/NDUFS4/PSMA1/PSMB2/NDUFAB1/OPTN/TRAF2/BCL2L1/PSMB3/PFN2/ACTB/TNF/ACTR10/SDHD/PRPH/PSMA8/PPP3CA/VDAC1/NXT1/SIGMAR1/NUP35/PSMB5/DCTN3/ACTG1/UQCRHL/DNAH6	42
KEGG	hsa03010	Ribosome	16/1169	158/8135	0.9559	1	0.706	RPS3A/MRPS9/RPL7/MRPL1/RPL22/RPL36AL/RPL26L1/RPL37A/MRPS18C/MRPL24/RPL15/MRPL14/MRPL3/MRPL13/MRPL17/RPS18	16
KEGG	hsa03060	Protein export	1/1169	23/8135	0.9719	1	0.706	SEC61G	1
KEGG	hsa04614	Renin-angiotensin system	1/1169	23/8135	0.9719	1	0.706	ANPEP	1
KEGG	hsa05150	Staphylococcus aureus infection	8/1169	96/8135	0.9744	1	0.706	ICAM1/C3/KRT14/KRT16/KRT24/CFB/KRT19/HLA-DQB1	8
KEGG	hsa04260	Cardiac muscle contraction	7/1169	87/8135	0.975	1	0.706	ACTC1/TPM4/CACNA1F/ATP2A2/ATP1A4/MYH6/UQCRHL	7
KEGG	hsa03440	Homologous recombination	2/1169	41/8135	0.9865	1	0.706	RPA2/UIMC1	2
KEGG	hsa03460	Fanconi anemia pathway	3/1169	54/8135	0.9886	1	0.706	RPA2/UBE2T/RMI1	3
KEGG	hsa00190	Oxidative phosphorylation	11/1169	134/8135	0.9897	1	0.706	ATP6V1E2/COX11/ATP6V0B/ATP6V0E2/NDUFB7/COX17/NDUFS4/NDUFAB1/SDHD/ATP6V1E1/UQCRHL	11
KEGG	hsa00860	Porphyrin metabolism	2/1169	43/8135	0.9897	1	0.706	HMOX2/ALAS1	2
KEGG	hsa05016	Huntington disease	31/1169	306/8135	0.99	1	0.706	SOD2/TUBB3/PSMA6/ERN1/PPARGC1A/PSMB7/PPIF/PSMA3/WIPI1/NDUFB7/CLTC/DCTN1/GRIA3/NDUFS4/PSMA1/PLCB4/PSMB2/NDUFAB1/TRAF2/PSMB3/CACNA1B/ACTR10/SDHD/DLG4/PSMA8/VDAC1/PPARG/PSMB5/DCTN3/UQCRHL/DNAH6	31
KEGG	hsa04613	Neutrophil extracellular trap formation	17/1169	190/8135	0.9914	1	0.706	NFKB1/PIK3CD/PRKCA/C3/AQP9/PPIF/VWF/CYBA/PIK3R2/MAPK13/GSDMD/PIK3R3/PLCB4/ATG7/ACTB/VDAC1/ACTG1	17
KEGG	hsa04080	Neuroactive ligand-receptor interaction	36/1169	353/8135	0.9929	1	0.706	BDKRB1/S1PR3/BDKRB2/ADORA2A/C3/GIP/PTGFR/P2RY11/OXTR/EDN1/PTGER2/GHR/ADM2/MC1R/F2R/LPAR1/GRIA3/THRA/ADORA1/P2RX3/CHRNB1/CNR2/IAPP/UTS2R/ADRB3/S1PR5/GRM2/GABRA3/GRIK4/GRIN3A/TAAR2/NMUR2/KISS1R/P2RX7/ADORA3/ADRA2A	36
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	3/1169	66/8135	0.9975	1	0.706	NARS2/FARSB/MARS2	3
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	6/1169	109/8135	0.9991	1	0.706	NXF1/RCL1/GNL3/REXO2/NXT1/IMP3	6
KEGG	hsa03040	Spliceosome	7/1169	147/8135	1	1	0.706	CCDC12/RBM17/ACIN1/DDX5/LSM6/DDX46/SF3B3	7
KEGG	hsa05322	Systemic lupus erythematosus	6/1169	136/8135	1	1	0.706	C3/CD40/TRIM21/TNF/ACTN4/HLA-DQB1	6
KEGG	hsa05034	Alcoholism	10/1169	187/8135	1	1	0.706	ADORA2A/CALM1/GNG11/GNB4/ARAF/CAMKK2/CALM2/GRIN3A/SLC29A1/GNG2	10
KEGG	hsa04740	Olfactory transduction	22/1169	440/8135	1	1	0.706	PDE1C/CALM1/CAMK2D/PDE1A/RGS2/OR5I1/OR2AE1/ADCY3/OR9A4/CAMK2G/CALM2/OR4N5/OR6V1/OR4F5/OR8U8/OR2T6/OR51G1/OR13C8/OR4C46/OR10X1/OR51M1/OR5M3	22