ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05169	Epstein-Barr virus infection	97/1765	202/8135	4.58e-17	1.525e-14	9.545e-15	CDKN1A/GADD45A/HLA-DMB/HLA-DPB1/GADD45B/SYK/BLNK/HLA-DMA/TRAF3/HLA-DPA1/RUNX3/MYC/CD3D/PLCG2/HLA-DRA/CXCL10/HLA-DOB/BTK/FADD/ITGAL/JUN/OAS2/HES1/NFKBIA/ENTPD1/MYD88/OAS1/MAPK13/TAP1/CD19/IFNAR2/TAPBP/LYN/CD3E/IRF9/STAT1/HLA-DOA/CD247/CASP8/GADD45G/DDB2/SNW1/OAS3/DDX58/PIK3CD/CD3G/RELA/HLA-F/PDIA3/ISG15/CD40/TRADD/MAP2K6/B2M/HLA-G/PIK3R1/TNF/HLA-B/BCL2L11/SAP30/IKBKE/HDAC1/HLA-C/CCND1/TRAF5/RB1/BID/HLA-A/CCNE1/HLA-DQA1/CCNA2/EIF2AK2/IRAK4/PSMD11/PSMD14/PSMD12/FAS/PIK3R3/IFNA1/BCL2/IL6/RAC1/BAX/BAK1/CD58/HLA-DRB4/CDK2/CHUK/TNFAIP3/CASP3/HLA-DQB1/NFKBIE/IRF7/PSMC4/CDKN1B/IRAK1/USP7	97
KEGG	hsa05416	Viral myocarditis	38/1765	60/8135	3.74e-12	4.477e-10	2.802e-10	RAC2/HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/ITGB2/HLA-DOB/ITGAL/LAMA2/PRF1/HLA-DOA/CD86/CASP8/SGCA/ABL1/HLA-F/CD40/ACTB/CXADR/HLA-G/HLA-B/SGCD/HLA-C/CCND1/BID/HLA-A/CD40LG/HLA-DQA1/ABL2/CD55/EIF4G1/RAC1/HLA-DRB4/CASP3/HLA-DQB1/FYN	38
KEGG	hsa04380	Osteoclast differentiation	63/1765	128/8135	4.033e-12	4.477e-10	2.802e-10	LILRB2/FCGR3B/NCF1/SYK/FOSL2/BLNK/LCP2/FOSB/LILRB3/LCK/LILRB1/PLCG2/CSF1R/JUNB/LILRB4/JUND/BTK/JUN/NFKBIA/SOCS3/MAPK13/NCF4/TYROBP/PPARG/TREM2/TNFSF11/GRB2/IFNAR2/FCGR2B/IRF9/STAT1/FOS/NCF2/CYBA/FCGR2A/TGFB2/PIK3CD/LILRA6/IL1R1/RELA/FCGR2C/SPI1/IL1B/MAP2K6/ACP5/PIK3R1/TNF/IFNGR2/SQSTM1/SIRPG/TGFBR2/CTSK/LILRB5/PIK3R3/MAPK3/RAC1/TNFRSF11B/MAPK1/CHUK/LILRA3/GAB2/CSF1/FYN	63
KEGG	hsa05130	Pathogenic Escherichia coli infection	83/1765	197/8135	5.635e-11	3.824e-09	2.394e-09	PTPN6/MYO1F/NCKAP1L/ARPC1B/ARPC2/CASP1/WASF3/FADD/JUN/ARPC5/CYTH4/WIPF1/NFKBIA/PYCARD/ACTR3/MYD88/MAPK13/CYFIP2/MYH11/FOS/TNFSF10/FCGR2A/WASL/CASP8/NCL/CYTH1/MYO10/MYO5C/CYFIP1/ARPC1A/IL1R1/ABL1/RELA/TJP1/ACTR2/MYO1B/ARPC3/MYO5A/IL1B/TRADD/ACTB/CLDN5/TUBA1A/NCKAP1/SEC24A/TNF/TMBIM6/NAIP/BAIAP2/TUBA4A/LPAR1/TUBA1B/WASF1/IRAK4/CTTN/F2R/TLR5/ROCK2/PAK2/FAS/GNA12/TUBA1C/MAPK3/IL6/RAC1/BAX/TMED10/BAK1/ARPC5L/RHOA/MAPK1/HCLS1/NLRP3/CHUK/CASP3/LPAR2/PAK1/FASLG/ABCF2/IRAK1/MYO1E/CLDN7/FYN	83
KEGG	hsa05140	Leishmaniasis	43/1765	77/8135	5.742e-11	3.824e-09	2.394e-09	FCGR3B/HLA-DMB/HLA-DPB1/NCF1/HLA-DMA/HLA-DPA1/PTPN6/CYBB/HLA-DRA/ITGB2/ITGAM/HLA-DOB/JUN/PRKCB/NFKBIA/MYD88/MAPK13/NCF4/PTGS2/STAT1/HLA-DOA/FOS/NCF2/CYBA/FCGR2A/ITGA4/TGFB2/JAK2/MARCKSL1/RELA/CR1/FCGR2C/IL1B/TNF/IFNGR2/HLA-DQA1/IRAK4/TGFB3/MAPK3/HLA-DRB4/MAPK1/HLA-DQB1/IRAK1	43
KEGG	hsa05164	Influenza A	74/1765	171/8135	1.42e-10	7.88e-09	4.932e-09	HLA-DMB/HLA-DPB1/HLA-DMA/TRAF3/HLA-DPA1/MX2/HLA-DRA/CASP1/TLR7/CCL5/DNAJB1/CXCL10/HLA-DOB/FADD/PRKCB/OAS2/NFKBIA/PYCARD/SOCS3/MYD88/OAS1/IFNAR2/NXF1/IRF9/STAT1/HLA-DOA/TNFSF10/CASP8/NXT1/OAS3/DDX58/PIK3CD/IFIH1/JAK2/CALCOCO2/RELA/MX1/RSAD2/IL1B/TRADD/ACTB/EIF2S1/TICAM1/PIK3R1/TNF/TLR3/IKBKE/CREBBP/IFNGR2/KPNA2/BID/CIITA/RAF1/HLA-DQA1/EIF2AK2/IRAK4/ADAR/FAS/PIK3R3/IFNA1/PML/MAPK3/IL6/BAX/BAK1/HLA-DRB4/MAPK1/NLRP3/CHUK/CASP3/HLA-DQB1/FASLG/IRF7/SLC25A6	74
KEGG	hsa05171	Coronavirus disease - COVID-19	91/1765	232/8135	6.485e-10	2.708e-08	1.695e-08	SYK/TRAF3/CYBB/MX2/C6/PLCG2/C7/CASP1/CFD/TLR7/AGTR1/CXCL10/C1QA/MMP1/JUN/PRKCB/OAS2/NFKBIA/EGFR/RPS28/MYD88/OAS1/MAPK13/C2/HBEGF/IFNAR2/IRF9/STAT1/FOS/FCGR2A/IL6ST/RPS23/OAS3/DDX58/PIK3CD/IFIH1/C3AR1/RELA/MX1/RPLP0/RPL23A/ISG15/RPL3/IL1B/TLR8/RPL30/RPS12/C1QB/RPL11/PIK3R1/TNF/TLR3/MMP3/IKBKE/RPL39/RPL29/RPL7/RPS17/RPL24/RPL19/EIF2AK2/IRAK4/RPS4Y1/RPL31/ADAR/RPS27A/RPS15/RPL12/NRP1/RPL14/C1R/PIK3R3/IFNA1/MAPK3/IL6/RPL41/RPL32/MAPK1/RPS5/RPL18/NLRP3/CHUK/RPL9/RPL34/RPS27/RSL24D1/IRAK1/C5/C5AR1/RPS27L/CFB	91
KEGG	hsa05132	Salmonella infection	96/1765	249/8135	6.506e-10	2.708e-08	1.695e-08	RHOB/PTPRC/NCKAP1L/MYC/ARPC1B/TCF7L2/ARPC2/CASP1/WASF3/TCF7L1/LY96/CD14/FADD/JUN/ARPC5/CYTH4/NFKBIA/PYCARD/ACTR3/MYD88/MAPK13/CYFIP2/FOS/TNFSF10/RHOH/FHOD1/WASL/RHOG/LEF1/CASP8/HSP90AB1/S100A10/CYTH1/PIK3CD/CYFIP1/ACBD3/ARPC1A/DYNC1I1/RALA/RELA/DYNLT3/HSP90AA1/DYNLL1/ACTR2/ARPC3/DCTN6/PIK3CG/IL1B/TRADD/ACTB/MAP2K6/TUBA1A/NCKAP1/PFN1/ANXA2/TNF/KIF5C/NAIP/TUBA4A/DYNC1LI2/DYNC2H1/EXOC2/RAF1/TUBA1B/BIRC3/IRAK4/DYNLT1/VPS41/TLR5/TCF7/MYL9/ROCK2/SKP1/BCL2/FYCO1/TUBA1C/MAPK3/IL6/RAC1/BAX/BAK1/ARPC5L/RHOA/MAPK1/ARHGEF26/NLRP3/CHUK/CASP3/PAK1/M6PR/PFN2/PLEKHM2/AHNAK2/KPNA3/IRAK1/DCTN5	96
KEGG	hsa04210	Apoptosis	60/1765	136/8135	3.246e-09	1.201e-07	7.516e-08	GADD45A/GADD45B/DDIT3/CTSB/CTSH/FADD/GZMB/JUN/NFKBIA/ATF4/PARP1/ATM/PRF1/CSF2RB/PARP4/FOS/TNFSF10/CTSS/CASP8/GADD45G/PMAIP1/PIK3CD/CTSC/BCL2A1/RELA/TRAF1/TRADD/ACTB/TUBA1A/EIF2S1/PIK3R1/TNF/ITPR3/BCL2L11/DFFB/TUBA4A/CTSW/CTSO/BID/RAF1/EIF2AK3/TUBA1B/CTSL/BIRC3/CTSK/FAS/PIK3R3/BCL2/TUBA1C/MAPK3/BAX/BAK1/MAPK1/CHUK/CASP3/CTSZ/CTSF/FASLG/PTPN13/ITPR1	60
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	47/1765	97/8135	4.228e-09	1.296e-07	8.114e-08	RAC2/FCGR3B/NCF1/SYK/PTPRC/MARCKS/ARPC1B/PLCG2/ARPC2/WASF3/INPP5D/PRKCB/ARPC5/VAV1/LAT/WAS/HCK/GSN/ACTR3/VASP/LYN/FCGR2B/ASAP3/FCGR2A/MYO10/PIK3CD/PLA2G4C/ARPC1A/MARCKSL1/ACTR2/ARPC3/BIN1/PIK3R1/AMPH/VAV3/RAF1/WASF1/RPS6KB1/PIK3R3/DOCK1/PRKCD/MAPK3/RAC1/ARPC5L/MAPK1/GAB2/PAK1	47
KEGG	hsa04062	Chemokine signaling pathway	77/1765	192/8135	4.283e-09	1.296e-07	8.114e-08	RAC2/NCF1/CCR2/ADCY7/PLCG2/CCR1/CCR5/XCL1/CCL5/CXCL13/CXCL10/PARD3/PRKACB/DOCK2/CCL18/PRKCB/VAV1/WAS/HCK/NFKBIA/FOXO3/CXCL9/CXCL12/GRB2/LYN/STAT1/FGR/GNG5/CX3CR1/ARRB2/CCR7/ITK/PLCB1/CXCL6/PIK3CD/CCL13/CXCR3/RASGRP2/ADCY3/JAK2/CX3CL1/GNAI2/RELA/PLCB3/PIK3CG/GRK6/CXCR4/PIK3R1/GRK5/CXCL2/ARRB1/VAV3/CCL19/CXCL11/GNG12/PTK2/RAF1/RAP1B/ROCK2/GNG10/PIK3R3/CXCL3/GNB1/PRKCD/CCL7/MAPK3/RAC1/RHOA/PLCB4/MAPK1/PTK2B/CXCR6/CHUK/CCR6/PAK1/CCL20/GNG7	77
KEGG	hsa04940	Type I diabetes mellitus	27/1765	43/8135	6.796e-09	1.886e-07	1.18e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/HLA-DOB/GZMB/HSPD1/PRF1/HLA-DOA/CD86/HLA-F/IL1B/HLA-G/TNF/HLA-B/HLA-C/HLA-A/HLA-DQA1/ICA1/GAD1/FAS/HLA-DRB4/CPE/HLA-DQB1/FASLG	27
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	85/1765	222/8135	9.307e-09	2.384e-07	1.492e-07	CDKN1A/HLA-DMB/HLA-DPB1/ZFP36/HLA-DMA/HLA-DPA1/ADCY7/MYC/CD4/LCK/CD3D/HLA-DRA/PTTG1/IL2RB/ITGB2/EGR1/IL2RG/HLA-DOB/PRKACB/ITGAL/SMAD3/JUN/CDC20/NFKBIA/ATF4/ATM/ETS2/IL15/CD3E/HLA-DOA/FOS/TLN2/TGFB2/PIK3CD/CD3G/KAT5/ADCY3/PTEN/IL1R1/RELA/HLA-F/EGR2/IL15RA/CD40/SPI1/CCNB2/MSX2/TRRAP/B2M/HLA-G/PIK3R1/TNF/HLA-B/NFYB/CREBBP/RAN/HLA-C/CCND1/RB1/HLA-A/CRTC3/CCNE1/HLA-DQA1/CCNA2/ANAPC15/BUB1B/TGFBR2/MAD2L1/TGFB3/NRP1/POLB/SLC2A1/PIK3R3/SRF/MAPK3/IL6/BAX/HLA-DRB4/CDC23/CDK2/MAPK1/CHUK/HLA-DQB1/CDC16/SLC25A6	85
KEGG	hsa05145	Toxoplasmosis	51/1765	112/8135	1.351e-08	3.213e-07	2.011e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CCR5/LY96/HLA-DOB/ALOX5/NFKBIA/MYD88/LAMA2/MAPK13/IL10RA/STAT1/HLA-DOA/CASP8/LAMA4/TGFB2/JAK2/LAMA3/GNAI2/RELA/CD40/PIK3CG/LDLR/IL10RB/MAP2K6/LAMC1/TNF/LAMA5/LAMC3/IFNGR2/CIITA/CD40LG/HLA-DQA1/LAMC2/BIRC3/IRAK4/TGFB3/LAMB2/BCL2/MAPK3/HLA-DRB4/MAPK1/CHUK/CASP3/HLA-DQB1/HSPA2/PPIF/IRAK1	51
KEGG	hsa05152	Tuberculosis	72/1765	180/8135	1.558e-08	3.458e-07	2.164e-07	FCGR3B/HLA-DMB/HLA-DPB1/CORO1A/SYK/HLA-DMA/HLA-DPA1/CD74/CLEC7A/RFX5/CALML4/HLA-DRA/CEBPB/ITGB2/ITGAM/HLA-DOB/CD14/FADD/MYD88/MAPK13/VDR/IL10RA/HSPD1/FCGR2B/STAT1/HLA-DOA/CTSS/FCGR2A/MRC2/CASP8/TGFB2/NOD2/JAK2/RELA/LAMP2/CR1/FCER1G/FCGR2C/HSPA9/IL1B/TRADD/IL10RB/ATP6V0B/TNF/TLR1/NFYB/ITGAX/PLK3/TCIRG1/CREBBP/IFNGR2/BID/CIITA/RAF1/HLA-DQA1/IRAK4/MALT1/TGFB3/ATP6V0D1/IFNA1/BCL2/MAPK3/IL6/BAX/RHOA/HLA-DRB4/MAPK1/CASP3/HLA-DQB1/CAMP/CEBPG/IRAK1	72
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	76/1765	194/8135	1.816e-08	3.78e-07	2.366e-07	CDKN1A/ZFP36/SYK/TRAF3/MYC/CALML4/PLCG2/TCF7L2/CCR1/CCR5/MICB/TCF7L1/FADD/JUN/HCK/NFKBIA/MAPK13/PTGS2/IFNAR2/LYN/IRF9/STAT1/GNG5/FGF2/FOS/UBC/CD86/LEF1/IL6ST/CASP8/MAP1LC3B/PIK3CD/VEGFA/JAK2/RELA/HLA-F/PIK3CG/TRADD/MAP2K6/HLA-G/TICAM1/PIK3R1/ITPR3/TLR3/HLA-B/CXCL2/IKBKE/CREBBP/HLA-C/GNG12/CCND1/RB1/BID/HLA-A/RAF1/EIF2AK2/RPS27A/TCF7/GNG10/FAS/PIK3R3/CXCL3/IFNA1/GNB1/MAPK3/IL6/RAC1/BAX/BAK1/MAPK1/CHUK/CASP3/IRF7/CLEC2B/GNG7/ITPR1	76
KEGG	hsa04064	NF-kappa B signaling pathway	48/1765	104/8135	2.116e-08	4.146e-07	2.595e-07	GADD45A/GADD45B/SYK/BLNK/TRAF3/LCK/PLCG2/LY96/CD14/BTK/PRKCB/LAT/NFKBIA/MYD88/PTGS2/PARP1/ATM/CXCL12/TNFSF11/LYN/LTB/ZAP70/GADD45G/DDX58/CCL13/BCL2A1/IL1R1/RELA/TRAF1/CD40/IL1B/TRADD/TICAM1/TNF/CXCL2/PRKCQ/CCL19/CSNK2A2/TRAF5/CD40LG/BIRC3/IRAK4/MALT1/CXCL3/BCL2/CHUK/TNFAIP3/IRAK1	48
KEGG	hsa05323	Rheumatoid arthritis	44/1765	93/8135	3.271e-08	6.051e-07	3.787e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/ITGB2/CCL5/HLA-DOB/ITGAL/MMP1/JUN/CXCL12/TNFSF11/IL15/LTB/HLA-DOA/FOS/ATP6V0E2/CD86/ATP6V1A/TGFB2/CXCL6/VEGFA/IL1B/ATP6V0B/ACP5/TNF/CXCL2/MMP3/TCIRG1/HLA-DQA1/ATP6V1D/CTSL/TGFB3/CTSK/ATP6V0D1/CXCL3/IL6/HLA-DRB4/TNFSF13/HLA-DQB1/CSF1/CCL20	44
KEGG	hsa05330	Allograft rejection	24/1765	38/8135	4.033e-08	7.069e-07	4.424e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/HLA-DOB/GZMB/PRF1/HLA-DOA/CD86/HLA-F/CD40/HLA-G/TNF/HLA-B/HLA-C/HLA-A/CD40LG/HLA-DQA1/FAS/HLA-DRB4/HLA-DQB1/FASLG	24
KEGG	hsa04662	B cell receptor signaling pathway	40/1765	82/8135	4.753e-08	7.914e-07	4.953e-07	RAC2/LILRB2/SYK/BLNK/LILRB3/PTPN6/LILRB1/PLCG2/RASGRP3/LILRB4/CD79A/BTK/INPP5D/JUN/PRKCB/VAV1/NFKBIA/CD19/GRB2/LYN/FCGR2B/FOS/PIK3CD/CD72/LILRA6/RELA/PIK3R1/VAV3/CD79B/RAF1/MALT1/LILRB5/PIK3R3/MAPK3/RAC1/MAPK1/CD22/CHUK/LILRA3/NFKBIE	40
KEGG	hsa04520	Adherens junction	36/1765	71/8135	6.317e-08	9.914e-07	6.205e-07	RAC2/PTPN6/SORBS1/TCF7L2/WASF3/TCF7L1/PARD3/SMAD3/WAS/EGFR/WASL/LEF1/NLK/TJP1/SNAI1/ACTB/PTPRM/YES1/FER/BAIAP2/CSNK2A2/CREBBP/VCL/IGF1R/WASF1/TGFBR2/TCF7/FGFR1/MET/MAPK3/RAC1/RHOA/MAPK1/SNAI2/FYN/PTPRF	36
KEGG	hsa04145	Phagosome	62/1765	152/8135	6.668e-08	9.914e-07	6.205e-07	FCGR3B/HLA-DMB/HLA-DPB1/CORO1A/NCF1/HLA-DMA/HLA-DPA1/CYBB/CLEC7A/HLA-DRA/ITGB2/ITGAM/HLA-DOB/CD14/NCF4/THBS3/TAP1/FCGR2B/HLA-DOA/NCF2/ATP6V0E2/CTSS/CYBA/FCGR2A/MRC2/ATP6V1A/MARCO/DYNC1I1/LAMP2/ITGA5/HLA-F/FCGR2C/ACTB/TUBA1A/ATP6V0B/HLA-G/HLA-B/OLR1/TCIRG1/TUBA4A/DYNC1LI2/SEC61B/HLA-C/DYNC2H1/HLA-A/HLA-DQA1/ATP6V1D/TUBA1B/CTSL/COMP/THBS1/ATP6V0D1/C1R/TUBA1C/RAC1/HLA-DRB4/TFRC/HLA-DQB1/M6PR/STX7/THBS2/COLEC12	62
KEGG	hsa05162	Measles	58/1765	139/8135	6.847e-08	9.914e-07	6.205e-07	TRAF3/MX2/CD3D/CD28/TLR7/IL2RB/IL2RG/FADD/JUN/OAS2/NFKBIA/MYD88/OAS1/CBLB/IFNAR2/FCGR2B/CD3E/IRF9/STAT1/FOS/CASP8/OAS3/DDX58/PIK3CD/CD3G/IFIH1/RELA/MX1/IL1B/TRADD/EIF2S1/PIK3R1/IKBKE/CSNK2A2/CD46/CCND1/BID/CCNE1/EIF2AK3/EIF2AK2/IRAK4/ADAR/FAS/PIK3R3/IFNA1/BCL2/IL6/BAX/BAK1/CDK2/CHUK/TNFAIP3/CASP3/HSPA2/FASLG/IRF7/CDKN1B/IRAK1	58
KEGG	hsa04658	Th1 and Th2 cell differentiation	43/1765	92/8135	7.296e-08	1.012e-06	6.336e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/RUNX3/CD4/LCK/CD3D/HLA-DRA/IL2RB/IL2RG/HLA-DOB/JUN/LAT/NFKBIA/MAPK13/ZAP70/CD3E/STAT1/HLA-DOA/FOS/CD247/IL12RB1/CD3G/JAK2/JAG1/RELA/MAF/STAT4/PRKCQ/IFNGR2/NOTCH2/HLA-DQA1/NOTCH1/MAPK3/HLA-DRB4/MAPK1/CHUK/TBX21/HLA-DQB1/IL12RB2/NFKBIE/STAT6	43
KEGG	hsa04659	Th17 cell differentiation	48/1765	108/8135	9.172e-08	1.222e-06	7.646e-07	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/CD4/LCK/CD3D/HLA-DRA/IL2RB/IL2RG/IL27RA/HLA-DOB/SMAD3/JUN/LAT/IL21R/NFKBIA/MAPK13/RORA/ZAP70/CD3E/STAT1/HLA-DOA/FOS/CD247/IL6ST/HSP90AB1/IL12RB1/CD3G/JAK2/IL1R1/RELA/HSP90AA1/AHR/IL1B/PRKCQ/IFNGR2/HLA-DQA1/TGFBR2/MAPK3/IL6/HLA-DRB4/MAPK1/CHUK/TBX21/HLA-DQB1/NFKBIE/STAT6	48
KEGG	hsa05135	Yersinia infection	57/1765	137/8135	1.001e-07	1.282e-06	8.025e-07	RAC2/LCP2/CD4/LCK/ARPC1B/ARPC2/CASP1/RPS6KA1/JUN/ARPC5/VAV1/LAT/WAS/WIPF1/NFKBIA/PYCARD/ACTR3/MYD88/MAPK13/SKAP2/ZAP70/FOS/FCGR2A/ITGA4/WASL/RHOG/CD8A/PIK3CD/ARPC1A/RELA/ACTR2/ITGA5/ARPC3/IL1B/ACTB/MAP2K6/TICAM1/PIK3R1/TNF/BAIAP2/VAV3/PTK2/IRAK4/GIT2/ROCK2/PIK3R3/DOCK1/MAPK3/IL6/RAC1/ARPC5L/RHOA/MAPK1/PTK2B/NLRP3/CHUK/IRAK1	57
KEGG	hsa05417	Lipid and atherosclerosis	80/1765	215/8135	1.087e-07	1.341e-06	8.394e-07	NCF1/TRAF3/CYBB/CALML4/DDIT3/CASP1/CCL5/LY96/CD14/MMP1/JUN/VAV1/NFKBIA/PYCARD/ATF4/MYD88/MAPK13/NCF4/PPARG/XBP1/HSPD1/LYN/FOS/TNFSF10/NCF2/CYBA/ABCG1/CASP8/HSP90AB1/PLCB1/PIK3CD/JAK2/RELA/APOB/PLCB3/HSP90AA1/CD40/LDLR/IL1B/MAP2K6/MMP9/EIF2S1/TICAM1/PIK3R1/TNF/CXCL2/OLR1/MMP3/IKBKE/VAV3/BID/PTK2/CD40LG/EIF2AK3/VLDLR/IRAK4/RAP1B/ROCK2/HSPA5/FAS/PIK3R3/CXCL3/IFNA1/BCL2/MAPK3/IL6/RAC1/BAX/RHOA/PLCB4/MAPK1/NLRP3/CHUK/CASP3/HSPA2/FASLG/IRF7/POU2F1/IRAK1/ITPR1	80
KEGG	hsa05170	Human immunodeficiency virus 1 infection	79/1765	212/8135	1.215e-07	1.445e-06	9.045e-07	RAC2/CD4/CD3D/CALML4/PLCG2/APOBEC3G/CCR5/FADD/JUN/PRKCB/NFKBIA/MYD88/MAPK13/ATM/TAP1/AP1S2/TAPBP/CD3E/GNG5/FOS/CD247/CASP8/APOBEC3F/PIK3CD/CD3G/WEE1/GNAI2/RELA/APOBEC3B/HLA-F/PDIA3/CDK1/CCNB2/CCNB1/TRADD/MAP2K6/SAMHD1/CXCR4/B2M/HLA-G/PIK3R1/TNF/ITPR3/HLA-B/APOBEC3C/TNFRSF1B/HLA-C/GNG12/GNA11/TRAF5/BID/HLA-A/PTK2/RAF1/IRAK4/RPS6KB1/PAK2/RNF7/GNG10/SKP1/FAS/PIK3R3/IFNA1/BCL2/GNB1/MAPK3/RAC1/BAX/BAK1/MAPK1/PTK2B/CHUK/CASP3/PAK1/FASLG/AP1G2/IRAK1/GNG7/ITPR1	79
KEGG	hsa05142	Chagas disease	45/1765	102/8135	2.995e-07	3.44e-06	2.153e-06	CD3D/CCL5/C1QA/FADD/JUN/NFKBIA/MYD88/MAPK13/GNA15/CD3E/FOS/CD247/CASP8/PLCB1/TGFB2/PIK3CD/CD3G/GNAI2/RELA/PLCB3/IL1B/C1QB/TICAM1/PIK3R1/TNF/BDKRB2/PPP2R2A/IFNGR2/GNA11/IRAK4/TGFBR2/TGFB3/PPP2CB/FAS/PIK3R3/MAPK3/IL6/PLCB4/MAPK1/CHUK/PPP2R1B/PPP2R2D/FASLG/GNAL/IRAK1	45
KEGG	hsa04620	Toll-like receptor signaling pathway	45/1765	104/8135	5.892e-07	6.334e-06	3.964e-06	TRAF3/TLR7/CCL5/CXCL10/LY96/CD14/FADD/JUN/NFKBIA/MYD88/MAPK13/CXCL9/IFNAR2/STAT1/FOS/CD86/CASP8/PIK3CD/RELA/CD40/IRF5/IL1B/TLR8/MAP2K6/MAP3K8/TICAM1/PIK3R1/TNF/TLR1/TLR3/SPP1/IKBKE/CXCL11/IRAK4/CTSK/TLR5/PIK3R3/IFNA1/MAPK3/IL6/RAC1/MAPK1/CHUK/IRF7/IRAK1	45
KEGG	hsa05332	Graft-versus-host disease	24/1765	42/8135	5.896e-07	6.334e-06	3.964e-06	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/HLA-DOB/GZMB/PRF1/HLA-DOA/CD86/HLA-F/IL1B/HLA-G/TNF/HLA-B/HLA-C/HLA-A/HLA-DQA1/FAS/IL6/HLA-DRB4/HLA-DQB1/FASLG	24
KEGG	hsa04010	MAPK signaling pathway	99/1765	294/8135	9.459e-07	9.843e-06	6.16e-06	GADD45A/RAC2/GADD45B/MYC/CSF1R/DDIT3/RASGRP3/RASGRP1/JUND/EFNA5/CD14/NR4A1/RPS6KA1/PRKACB/MAP4K1/JUN/PRKCB/PTPN7/ATF4/EGFR/MYD88/MAPK13/DUSP1/NTRK2/GRB2/FGF2/FOS/ARRB2/GADD45G/STMN1/ECSIT/TGFB2/MAPKAPK3/VEGFA/PLA2G4C/RASGRP2/NLK/HSPB1/MAPK7/IL1R1/RELA/DUSP5/RASA1/VEGFC/CACNB2/EREG/IL1B/TRADD/DUSP4/MAP2K6/MKNK2/MAP3K8/TNF/PDGFD/MEF2C/MKNK1/TAOK3/ARRB1/MAP3K6/MAPKAPK5/STK3/GNG12/IGF1R/AREG/RRAS2/FGF4/RAF1/DUSP7/MAP3K4/MECOM/IRAK4/TGFBR2/PDGFC/DUSP2/TGFB3/MAP4K3/RAP1B/FGF23/PPM1A/FGFR1/PAK2/FAS/SRF/MET/DUSP10/GNA12/CDC25B/MAPK3/RAC1/MAPK1/CHUK/CASP3/PAK1/HSPA2/FASLG/CSF1/IRAK1/KITLG/MAP3K12	99
KEGG	hsa04668	TNF signaling pathway	47/1765	112/8135	9.777e-07	9.866e-06	6.175e-06	TRAF3/JUNB/CEBPB/CCL5/CXCL10/FADD/JUN/NFKBIA/ATF4/SOCS3/MAPK13/PTGS2/IL15/FOS/CASP8/CXCL6/PIK3CD/NOD2/CX3CL1/JAG1/RELA/VEGFC/TRAF1/IL1B/TRADD/MAP2K6/MMP9/MAP3K8/PIK3R1/TNF/CXCL2/MMP3/TNFRSF1B/TRAF5/BIRC3/FAS/PIK3R3/CXCL3/MAPK3/IL6/LIF/MAPK1/CHUK/TNFAIP3/CASP3/CSF1/CCL20	47
KEGG	hsa04612	Antigen processing and presentation	36/1765	78/8135	1.224e-06	1.198e-05	7.501e-06	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/CD74/RFX5/CD4/HLA-DRA/CTSB/HLA-DOB/TAP1/LGMN/TAPBP/HLA-DOA/CTSS/HSP90AB1/CD8A/HSP90AA1/HLA-F/PSME1/PDIA3/B2M/HLA-G/TNF/HLA-B/NFYB/HLA-C/HLA-A/CIITA/HLA-DQA1/CTSL/HSPA5/HLA-DRB4/HLA-DQB1/HSPA2/KIR2DS5	36
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	43/1765	100/8135	1.283e-06	1.22e-05	7.637e-06	CYBB/PLCG2/EGR1/AGTR1/COL3A1/COL1A2/SMAD3/JUN/PRKCB/MAPK13/PIM1/FOXO1/STAT1/COL1A1/PLCB1/TGFB2/PIK3CD/VEGFA/JAK2/RELA/PLCB3/VEGFC/IL1B/PIK3R1/TNF/NOX4/COL4A6/CCND1/TGFBR2/TGFB3/THBD/PIK3R3/BCL2/PRKCD/MAPK3/IL6/RAC1/BAX/PLCB4/MAPK1/CASP3/COL4A5/CDKN1B	43
KEGG	hsa05222	Small cell lung cancer	40/1765	92/8135	2.131e-06	1.972e-05	1.234e-05	CDKN1A/GADD45A/GADD45B/TRAF3/MYC/CKS1B/NFKBIA/LAMA2/PTGS2/GADD45G/DDB2/LAMA4/PIK3CD/PTEN/LAMA3/RELA/CKS2/TRAF1/LAMC1/PIK3R1/COL4A6/LAMA5/LAMC3/CCND1/TRAF5/RB1/PTK2/CCNE1/LAMC2/BIRC3/LAMB2/PIK3R3/BCL2/BAX/BAK1/CDK2/CHUK/CASP3/COL4A5/CDKN1B	40
KEGG	hsa05210	Colorectal cancer	38/1765	86/8135	2.365e-06	2.129e-05	1.332e-05	CDKN1A/GADD45A/RAC2/GADD45B/MYC/TCF7L2/TCF7L1/SMAD3/JUN/EGFR/GRB2/FOS/LEF1/GADD45G/DDB2/PMAIP1/TGFB2/PIK3CD/RALA/EREG/PIK3R1/BCL2L11/CCND1/AREG/RAF1/TGFBR2/TGFB3/RPS6KB1/TCF7/PIK3R3/BCL2/MAPK3/RAC1/BAX/BAK1/RHOA/MAPK1/CASP3	38
KEGG	hsa04936	Alcoholic liver disease	55/1765	142/8135	2.558e-06	2.21e-05	1.383e-05	TRAF3/ADH1B/TCF7L2/TCF7L1/LY96/CD14/ADH1C/C1QA/FADD/NFKBIA/MYD88/MAPK13/ADIPOQ/C2/FOXO3/FOXO1/ACACB/LEF1/CASP8/ADH5/FASN/C3AR1/TRA2B/RELA/SREBF1/PPARGC1A/SCD/IL1B/TRADD/MAP2K6/C1QB/PRKAA1/TICAM1/TNF/TRA2A/NOX4/CXCL2/IKBKE/ALDH2/CCND1/LPIN1/IRAK4/ADIPOR2/TCF7/FAS/CXCL3/IFNA1/IL6/ACACA/CHUK/CASP3/FASLG/IRAK1/C5/C5AR1	55
KEGG	hsa04640	Hematopoietic cell lineage	42/1765	99/8135	2.604e-06	2.21e-05	1.383e-05	HLA-DMB/HLA-DPB1/HLA-DMA/CD2/HLA-DPA1/CD4/CD3D/HLA-DRA/IL7R/CSF1R/ITGAM/HLA-DOB/CD14/CD38/CD37/CD19/CD3E/HLA-DOA/ITGA4/CD33/CD8A/CD3G/IL1R1/CR1/ITGA5/IL1B/CSF2RA/CSF3R/MS4A1/TNF/CD7/HLA-DQA1/IL7/CD55/IL6/CD24/HLA-DRB4/CD22/TFRC/HLA-DQB1/CSF1/KITLG	42
KEGG	hsa04142	Lysosome	52/1765	132/8135	2.654e-06	2.21e-05	1.383e-05	NAGA/GNPTAB/CTSB/CTSH/ACP2/DMXL2/MAN2B1/LGMN/AP1S2/CLTC/LAMP3/CTSS/ARSA/LAPTM5/CTSC/DNASE2/NPC2/LIPA/FUCA1/LAMP2/CD63/ATP6V0B/ACP5/PPT1/NPC1/HEXB/AGA/TCIRG1/CLTCL1/IGF2R/PLA2G15/LITAF/CTSW/CTSO/CTSL/HYAL1/TPP1/GGA2/CTSK/MANBA/ATP6V0D1/ARSB/CTSZ/CLTA/CTSF/M6PR/GNS/AP1G2/HEXA/GAA/GUSB/GALC	52
KEGG	hsa05321	Inflammatory bowel disease	31/1765	65/8135	2.824e-06	2.294e-05	1.436e-05	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/IL2RG/HLA-DOB/SMAD3/JUN/IL21R/RORA/STAT1/HLA-DOA/IL12RB1/TGFB2/NOD2/RELA/MAF/IL1B/STAT4/TNF/IFNGR2/HLA-DQA1/TGFB3/TLR5/IL6/HLA-DRB4/TBX21/HLA-DQB1/IL12RB2/STAT6	31
KEGG	hsa05165	Human papillomavirus infection	107/1765	331/8135	3.091e-06	2.451e-05	1.534e-05	CDKN1A/TRAF3/MX2/TCF7L2/COL1A2/TCF7L1/PARD3/FADD/PRKACB/FZD2/HES1/EGFR/LAMA2/THBS3/PTGS2/ATM/WNT11/FZD4/FOXO1/GRB2/IFNAR2/IRF9/STAT1/ATP6V0E2/ITGA4/COL1A1/FZD1/CASP8/ATP6V1A/LAMA4/PIK3CD/VEGFA/WNT5B/PTEN/JAG1/LAMA3/RELA/MX1/ITGA10/ITGA5/HLA-F/ISG15/TRADD/ATP6V0B/WNT5A/LAMC1/HLA-G/TICAM1/PIK3R1/TNF/TLR3/HLA-B/SPP1/COL4A6/TCIRG1/LAMA5/IKBKE/ITGB7/HDAC1/FZD10/LLGL2/CREBBP/LAMC3/ITGA7/PPP2R2A/HLA-C/CCND1/RB1/HLA-A/NOTCH2/PTK2/CCNE1/RAF1/LAMC2/CCNA2/ATP6V1D/EIF2AK2/MFNG/NOTCH1/HEY2/COMP/THBS1/RPS6KB1/PPP2CB/ATP6V0D1/PSEN1/LAMB2/TCF7/FAS/WNT16/PIK3R3/IFNA1/MAPK3/BAX/BAK1/CDK2/MAPK1/PPP2R5C/TUBG1/CHUK/CASP3/PPP2R1B/COL4A5/PPP2R2D/FASLG/THBS2/CDKN1B	107
KEGG	hsa05163	Human cytomegalovirus infection	78/1765	225/8135	3.983e-06	3.085e-05	1.931e-05	CDKN1A/RAC2/ADCY7/MYC/CALML4/CCR1/CCR5/CCL5/FADD/PRKACB/PRKCB/NFKBIA/ATF4/EGFR/MAPK13/PTGS2/IL10RA/TAP1/CXCL12/GRB2/TAPBP/GNG5/CASP8/PLCB1/PIK3CD/VEGFA/ADCY3/CX3CL1/IL1R1/GNAI2/RELA/PLCB3/HLA-F/PDIA3/IL1B/TRADD/IL10RB/MAP2K6/CXCR4/B2M/HLA-G/PIK3R1/TNF/ITPR3/HLA-B/HLA-C/GNG12/CCND1/GNA11/AKAP13/TRAF5/RB1/BID/HLA-A/PTK2/RAF1/RPS6KB1/ROCK2/GNG10/FAS/PIK3R3/IFNA1/GNA12/GNB1/MAPK3/IL6/RAC1/BAX/BAK1/RHOA/PLCB4/MAPK1/PTK2B/CHUK/CASP3/FASLG/GNG7/ITPR1	78
KEGG	hsa04657	IL-17 signaling pathway	40/1765	94/8135	4.097e-06	3.1e-05	1.941e-05	TRAF3/FOSB/CEBPB/JUND/CXCL10/FADD/MMP1/JUN/NFKBIA/MAPK13/MAPK6/PTGS2/TRAF3IP2/S100A8/FOS/S100A9/CASP8/HSP90AB1/CXCL6/MAPK7/RELA/HSP90AA1/IL1B/TRADD/MMP9/TNF/CXCL2/MMP3/MMP13/IKBKE/TRAF5/CXCL3/CCL7/MAPK3/IL6/MAPK1/CHUK/TNFAIP3/CASP3/CCL20	40
KEGG	hsa05202	Transcriptional misregulation in cancer	69/1765	193/8135	4.268e-06	3.158e-05	1.977e-05	CDKN1A/BCL6/GADD45A/GADD45B/ZBTB16/MYC/CSF1R/DDIT3/IL2RB/CEBPB/BMP2K/ITGAM/CD14/GZMB/PPARG/ATM/ID2/FOXO1/CD86/FLI1/TSPAN7/GADD45G/DDB2/TAF15/BCL2A1/BCL11B/RELA/MAF/TRAF1/MLF1/CD40/SPI1/MMP9/LYL1/MEF2C/MMP3/ITGB7/HDAC1/NR4A3/IGF1R/PTK2/HHEX/CEBPA/PBX1/CCNA2/BIRC3/JMJD1C/TGFBR2/TFE3/PER2/SUPT3H/ERG/PLAT/WNT16/MET/PML/IL6/BAX/BAK1/PAX5/KDM6A/BAIAP3/NUPR1/CCNT1/PAX8/PTCRA/SPINT1/CDKN1B/HOXA11	69
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	38/1765	89/8135	6.444e-06	4.665e-05	2.919e-05	PTPN6/CD4/LCK/CD3D/CD28/RASGRP1/JUN/LAT/NFKBIA/EGFR/MYD88/MAPK13/BATF/ZAP70/CD3E/STAT1/FOS/CD247/PIK3CD/CD3G/JAK2/PTEN/RELA/ALK/MAP2K6/TICAM1/PIK3R1/PRKCQ/CSNK2A2/EML4/IFNGR2/RAF1/RPS6KB1/PIK3R3/MAPK3/MAPK1/CHUK/NFKBIE	38
KEGG	hsa05160	Hepatitis C	58/1765	157/8135	7.847e-06	5.56e-05	3.48e-05	CDKN1A/TRAF3/MYC/MX2/CXCL10/FADD/OAS2/NFKBIA/SOCS3/EGFR/OAS1/GRB2/IFNAR2/NR1H3/IRF9/STAT1/IFIT1/CASP8/OAS3/DDX58/PIK3CD/RELA/MX1/LDLR/RSAD2/TRADD/CLDN5/EIF2S1/TICAM1/PIK3R1/TNF/TLR3/IKBKE/PPP2R2A/CCND1/RB1/BID/RAF1/EIF2AK3/PIAS1/EIF2AK2/PPP2CB/FAS/PIK3R3/IFNA1/MAPK3/BAX/BAK1/CDK2/MAPK1/CHUK/CASP3/PPP2R1B/PPP2R2D/FASLG/YWHAZ/IRF7/CLDN7	58
KEGG	hsa05161	Hepatitis B	59/1765	162/8135	1.094e-05	7.588e-05	4.749e-05	CDKN1A/TRAF3/MYC/FADD/SMAD3/JUN/PRKCB/NFKBIA/ATF4/MYD88/MAPK13/GRB2/STAT1/FOS/CASP8/DDB2/DDX58/TGFB2/PIK3CD/IFIH1/JAK2/RELA/EGR2/MAP2K6/MMP9/STAT4/TICAM1/PIK3R1/TNF/TLR3/PCNA/IKBKE/EGR3/CREBBP/RB1/BID/CCNE1/RAF1/CCNA2/IRAK4/TGFBR2/TGFB3/FAS/PIK3R3/IFNA1/BCL2/MAPK3/IL6/BAX/CDK2/MAPK1/PTK2B/CHUK/CASP3/FASLG/YWHAZ/IRF7/IRAK1/STAT6	59
KEGG	hsa04660	T cell receptor signaling pathway	42/1765	104/8135	1.162e-05	7.779e-05	4.869e-05	PTPRC/LCP2/PTPN6/CD4/LCK/CD3D/CD28/RASGRP1/JUN/VAV1/LAT/NFKBIA/MAPK13/CBLB/GRB2/ZAP70/CD3E/FOS/CD247/ITK/CD8A/PIK3CD/CD3G/RELA/MAP3K8/PIK3R1/TNF/PRKCQ/VAV3/CD40LG/RAF1/MALT1/PAK2/PIK3R3/MAPK3/RHOA/MAPK1/CHUK/ICOS/PAK1/NFKBIE/FYN	42
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	50/1765	131/8135	1.168e-05	7.779e-05	4.869e-05	RAC2/FCGR3B/SYK/CD48/LCP2/PTPN6/LCK/PLCG2/ITGB2/MICB/ITGAL/GZMB/PRKCB/VAV1/LAT/TYROBP/PRF1/GRB2/IFNAR2/ZAP70/TNFSF10/CD247/SH2D1A/PIK3CD/FCER1G/HLA-G/PIK3R1/TNF/HLA-B/CD244/VAV3/HLA-C/IFNGR2/SH3BP2/BID/HLA-A/RAF1/NCR3/FAS/PIK3R3/IFNA1/MAPK3/RAC1/MAPK1/PTK2B/CASP3/PAK1/FASLG/KIR2DS5/FYN	50
KEGG	hsa05131	Shigellosis	82/1765	247/8135	1.486e-05	9.702e-05	6.072e-05	ARPC1B/PLCG2/ARPC2/CASP1/CCL5/HK3/CD14/JUN/ARPC5/CYTH4/NFKBIA/PYCARD/ACTR3/EGFR/MYD88/MAPK13/FOXO3/ATM/BNIP3/FOXO1/FNBP1/RRAGA/RRAGC/UBC/WASL/FNBP1L/PLCB1/MAP1LC3B/TLN2/CYTH1/PIK3CD/ARPC1A/IL1R1/CALCOCO2/RELA/PLCB3/ACTR2/ITGA5/ARPC3/IL1B/TRADD/ACTB/PFN1/RRAGB/PIK3R1/TNF/ITPR3/PRKCQ/NAIP/VCL/RBCK1/TRAF5/SQSTM1/PPID/PTK2/WASF1/CTTN/MALT1/RPS27A/RPS6KB1/TLR5/UBE2D3/MYL9/ROCK2/FOXO4/SKP1/PIK3R3/DOCK1/BCL2/PRKCD/MAPK3/RAC1/BAX/ARPC5L/RHOA/PLCB4/MAPK1/HCLS1/NLRP3/CHUK/PFN2/ITPR1	82
KEGG	hsa05146	Amoebiasis	41/1765	102/8135	1.683e-05	0.0001062	6.648e-05	ITGB2/ITGAM/COL3A1/COL1A2/CD14/PRKACB/PRKCB/LAMA2/GNA15/COL1A1/LAMA4/PLCB1/TGFB2/PIK3CD/HSPB1/IL1R1/LAMA3/RELA/PLCB3/IL1B/LAMC1/PIK3R1/TNF/CXCL2/COL4A6/LAMA5/LAMC3/VCL/ARG2/GNA11/PTK2/LAMC2/TGFB3/LAMB2/PIK3R3/CXCL3/IL6/PLCB4/CASP3/COL4A5/GNAL	41
KEGG	hsa05133	Pertussis	33/1765	76/8135	1.691e-05	0.0001062	6.648e-05	CALML4/CASP1/ITGB2/ITGAM/LY96/CD14/C1QA/SERPING1/JUN/IRF8/PYCARD/MYD88/MAPK13/C2/FOS/CXCL6/GNAI2/RELA/ITGA5/IL1B/C1QB/TICAM1/TNF/IRAK4/C1R/MAPK3/IL6/RHOA/MAPK1/NLRP3/CASP3/IRAK1/C5	33
KEGG	hsa04672	Intestinal immune network for IgA production	24/1765	49/8135	2.127e-05	0.0001311	8.208e-05	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/TNFRSF17/HLA-DOB/CXCL12/IL15/HLA-DOA/CD86/ITGA4/IL15RA/CD40/CXCR4/ITGB7/CD40LG/HLA-DQA1/IL6/HLA-DRB4/ICOS/TNFSF13/HLA-DQB1	24
KEGG	hsa05205	Proteoglycans in cancer	70/1765	205/8135	2.2e-05	0.0001332	8.338e-05	CDKN1A/SDC1/PTPN6/MYC/PLCG2/COL1A2/PRKACB/PRKCB/FZD2/VAV1/SDC4/EGFR/MAPK13/WNT11/HBEGF/FZD4/HPSE/GRB2/FGF2/PPP1CA/COL1A1/FZD1/TGFB2/PIK3CD/VEGFA/WNT5B/DCN/ITGA5/HSPB2/ACTB/CD63/MMP9/WNT5A/PIK3R1/TNF/ITPR3/CAV2/VAV3/FZD10/PPP1CB/CCND1/IGF1R/RRAS2/PTK2/RAF1/CTSL/CTTN/THBS1/RPS6KB1/ANK2/FGFR1/ROCK2/TIMP3/FAS/WNT16/PIK3R3/MET/TWIST1/MAPK3/RAC1/RHOA/MAPK1/HCLS1/PPP1R12A/CASP3/EIF4B/PAK1/FASLG/ITPR1/GPC3	70
KEGG	hsa05215	Prostate cancer	39/1765	97/8135	2.666e-05	0.0001586	9.924e-05	CDKN1A/TCF7L2/TCF7L1/NFKBIA/ATF4/EGFR/AR/FOXO1/GRB2/LEF1/HSP90AB1/PIK3CD/PTEN/RELA/HSP90AA1/MMP9/PIK3R1/PDGFD/MMP3/NKX3-1/CREBBP/CCND1/IGF1R/RB1/CCNE1/RAF1/PDGFC/TCF7/ERG/FGFR1/PLAT/PIK3R3/BCL2/MAPK3/CDK2/MAPK1/CHUK/SPINT1/CDKN1B	39
KEGG	hsa04810	Regulation of actin cytoskeleton	73/1765	218/8135	3.13e-05	0.0001828	0.0001144	RAC2/NCKAP1L/ARPC1B/ARPC2/ITGB2/ITGAM/ITGAL/IQGAP2/ARPC5/VAV1/GSN/ACTR3/EGFR/DIAPH2/CYFIP2/MYH11/CXCL12/ARHGEF6/FGF2/PPP1CA/ITGA4/WASL/PIK3CD/CYFIP1/ARPC1A/ACTR2/ITGA10/ITGA5/ARPC3/ACTB/NCKAP1/PFN1/CXCR4/PIK3R1/MYLK/PDGFD/ITGAX/BDKRB2/BAIAP2/ITGB7/VAV3/PPP1CB/ITGA7/VCL/GNG12/RRAS2/FGF4/PTK2/RAF1/LPAR1/WASF1/PDGFC/F2R/ARHGAP35/FGF23/FGFR1/MYL9/ROCK2/PAK2/PIK3R3/DOCK1/TMSB4X/GNA12/MAPK3/RAC1/ARPC5L/RHOA/MAPK1/PPP1R12A/LPAR2/PAK1/PFN2/BDKRB1	73
KEGG	hsa04115	p53 signaling pathway	31/1765	73/8135	5.108e-05	0.0002932	0.0001835	CDKN1A/GADD45A/GADD45B/RRM2/ZMAT3/ATM/TP53I3/CASP8/GADD45G/DDB2/PMAIP1/PTEN/CDK1/CCNB2/CCNB1/PERP/SIAH1/STEAP3/CCND1/BID/CCNE1/THBS1/CD82/RPRM/FAS/CCNG2/GTSE1/BCL2/BAX/CDK2/CASP3	31
KEGG	hsa04068	FoxO signaling pathway	48/1765	131/8135	5.926e-05	0.0003345	0.0002094	CDKN1A/BCL6/GADD45A/GADD45B/KLF2/GABARAPL1/IL7R/IRS2/SMAD3/EGFR/MAPK13/FOXO3/ATM/BNIP3/FOXO1/GRB2/TNFSF10/GADD45G/PCK1/TGFB2/PIK3CD/NLK/PTEN/CCNB2/CCNB1/IRS1/S1PR4/PRKAA1/PIK3R1/BCL2L11/PLK3/CREBBP/CCND1/IGF1R/RAF1/TGFBR2/TGFB3/FOXO4/PIK3R3/CCNG2/MAPK3/IL6/CDK2/MAPK1/CHUK/FASLG/CDKN1B/USP7	48
KEGG	hsa05418	Fluid shear stress and atherosclerosis	50/1765	139/8135	7.275e-05	0.0004038	0.0002527	RAC2/SDC1/NCF1/KLF2/CALML4/JUN/SDC4/MAPK13/DUSP1/ASS1/FOS/NCF2/CYBA/HSP90AB1/PIK3CD/VEGFA/NQO1/MAPK7/IL1R1/BMP4/RELA/HSP90AA1/IL1B/ACTB/ACVR2A/MAP2K6/MMP9/PRKAA1/PIK3R1/TNF/MEF2C/CAV2/SQSTM1/PTK2/CTSL/MGST3/SUMO4/THBD/PECAM1/PLAT/BMPR2/PIK3R3/BCL2/RAC1/RHOA/GSTM2/GSTO1/CHUK/BMPR1A/GSTM1	50
KEGG	hsa05320	Autoimmune thyroid disease	24/1765	53/8135	0.0001054	0.0005754	0.0003601	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/CD28/HLA-DOB/GZMB/PRF1/HLA-DOA/CD86/HLA-F/CD40/HLA-G/HLA-B/HLA-C/HLA-A/CD40LG/HLA-DQA1/FAS/IFNA1/HLA-DRB4/HLA-DQB1/FASLG	24
KEGG	hsa05340	Primary immunodeficiency	19/1765	38/8135	0.0001076	0.000578	0.0003618	PTPRC/BLNK/RFX5/CD4/LCK/CD3D/IL7R/CD79A/IL2RG/BTK/TAP1/CD19/ZAP70/CD3E/CD8A/CD40/CIITA/CD40LG/ICOS	19
KEGG	hsa04151	PI3K-Akt signaling pathway	106/1765	354/8135	0.000128	0.0006652	0.0004163	CDKN1A/SYK/MAGI2/MYC/IL7R/CSF1R/IL2RB/IL2RG/EFNA5/COL1A2/NR4A1/GHR/ATF4/EGFR/LAMA2/THBS3/PHLPP1/FOXO3/NTRK2/CD19/GRB2/IFNAR2/DDIT4/GNG5/FGF2/ITGA4/COL1A1/PCK1/HSP90AB1/LAMA4/PIK3CD/VEGFA/JAK2/PTEN/LAMA3/RELA/HSP90AA1/ITGA10/ITGA5/VEGFC/PIK3CG/EREG/IRS1/PRKAA1/CSF3R/LAMC1/PIK3R1/PDGFD/BCL2L11/SPP1/COL4A6/LAMA5/ITGB7/LAMC3/ITGA7/PPP2R2A/EIF4E2/GNG12/CCND1/IGF1R/AREG/FGF4/PTK2/CCNE1/RAF1/LPAR1/LAMC2/LPAR6/IL7/PDGFC/F2R/COMP/THBS1/RPS6KB1/PPP2CB/FGF23/LAMB2/FGFR1/GNG10/PIK3R3/MET/IFNA1/BCL2/GNB1/MAPK3/IL6/RAC1/CDK2/MAPK1/PPP2R5C/CHUK/LPAR2/PPP2R1B/EIF4B/COL4A5/TCL1B/TCL1A/PPP2R2D/FASLG/CSF1/YWHAZ/THBS2/CDKN1B/KITLG/GNG7/GYS2	106
KEGG	hsa04611	Platelet activation	45/1765	124/8135	0.0001295	0.0006652	0.0004163	SYK/LCP2/ADCY7/PLCG2/RASGRP1/COL3A1/COL1A2/BTK/PRKACB/MAPK13/VASP/LYN/PPP1CA/FCGR2A/COL1A1/PLCB1/TLN2/PIK3CD/PLA2G4C/RASGRP2/ADCY3/GNAI2/PLCB3/FCER1G/PIK3CG/VAMP8/ACTB/PIK3R1/MYLK/ITPR3/PPP1CB/TBXAS1/F2R/ARHGAP35/RAP1B/ROCK2/PTGS1/PIK3R3/MAPK3/RHOA/PLCB4/MAPK1/PPP1R12A/ITPR1/FYN	45
KEGG	hsa04514	Cell adhesion molecules	52/1765	149/8135	0.0001298	0.0006652	0.0004163	SDC1/HLA-DMB/HLA-DPB1/PTPRC/HLA-DMA/CD2/HLA-DPA1/SELPLG/CD4/ICAM3/HLA-DRA/CD28/SDC3/ITGB2/ITGAM/HLA-DOB/ITGAL/SDC4/SELL/JAM3/NLGN4X/HLA-DOA/SIGLEC1/CD86/ITGA4/CD8A/HLA-F/CD40/CLDN5/NLGN1/PTPRM/ALCAM/HLA-G/HLA-B/PDCD1LG2/ITGB7/HLA-C/HLA-A/CD40LG/HLA-DQA1/NLGN4Y/CADM1/PECAM1/NRXN1/CD58/GLG1/HLA-DRB4/CD22/ICOS/HLA-DQB1/CLDN7/PTPRF	52
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	38/1765	100/8135	0.0001417	0.000712	0.0004456	CCR2/CSF1R/CCR1/CCR5/XCL1/IL2RB/CCL5/IL2RG/CXCL13/CXCL10/CCL18/IL10RA/CXCL9/CXCL12/CX3CR1/TNFSF10/CCR7/IL6ST/ACKR3/CXCL6/CCL13/CXCR3/CX3CL1/IL10RB/CXCR4/TNF/CXCL2/CCL19/TNFRSF1B/CXCL11/TNFRSF10D/CXCL3/CCL7/IL6/CCR6/CSF1/CCL20/TNFRSF14	38
KEGG	hsa04510	Focal adhesion	66/1765	201/8135	0.0001433	0.000712	0.0004456	RAC2/COL1A2/JUN/PRKCB/VAV1/EGFR/LAMA2/THBS3/GRB2/VASP/PPP1CA/ITGA4/COL1A1/LAMA4/PARVA/TLN2/PIK3CD/VEGFA/PTEN/LAMA3/ITGA10/ITGA5/VEGFC/ACTB/LAMC1/PIK3R1/MYLK/PDGFD/SPP1/COL4A6/LAMA5/CAV2/ITGB7/VAV3/LAMC3/PPP1CB/ITGA7/VCL/CCND1/IGF1R/PTK2/RAF1/LAMC2/BIRC3/PDGFC/ARHGAP35/COMP/THBS1/RAP1B/LAMB2/MYL9/ROCK2/PAK2/PIK3R3/DOCK1/MET/BCL2/MAPK3/RAC1/RHOA/MAPK1/PPP1R12A/COL4A5/PAK1/THBS2/FYN	66
KEGG	hsa05221	Acute myeloid leukemia	28/1765	67/8135	0.0001626	0.0007961	0.0004983	ZBTB16/MYC/TCF7L2/CSF1R/PIM2/ITGAM/TCF7L1/CD14/PIM1/GRB2/LEF1/PIK3CD/BCL2A1/RELA/SPI1/PIK3R1/CCND1/CEBPA/RAF1/CCNA2/RPS6KB1/PER2/TCF7/PIK3R3/PML/MAPK3/MAPK1/CHUK	28
KEGG	hsa04060	Cytokine-cytokine receptor interaction	90/1765	295/8135	0.0002016	0.0009727	0.0006088	CCR2/CD4/IL7R/CSF1R/CCR1/CCR5/XCL1/IL2RB/CD27/CCL5/TNFRSF17/IL2RG/CXCL13/IL27RA/CXCL10/CCL18/GHR/IL21R/IL32/IL10RA/CXCL9/CXCL12/CSF2RB/TNFSF11/IFNAR2/IL15/LTB/CX3CR1/IL16/TNFSF10/GDF15/CCR7/INHBB/IL6ST/LEP/IL12RB1/ACKR3/TGFB2/TNFSF9/CXCL6/CCL13/CXCR3/CX3CL1/IL1R1/BMP4/TNFSF15/IL15RA/LIFR/CD40/IL1B/CSF2RA/IL10RB/ACVR2A/BMP5/CSF3R/CXCR4/TNF/CXCL2/CCL19/TNFRSF1B/CXCL11/TNFRSF10D/IFNGR2/CD40LG/IL7/CD70/TGFBR2/ACVR1B/TGFB3/FAS/BMPR2/CXCL3/IFNA1/CCL7/IL6/TNFRSF11B/CLCF1/LIF/CXCR6/BMP2/CCR6/TNFRSF25/TNFSF13/BMPR1A/IL12RB2/FASLG/CSF1/CCL20/IL1RN/TNFRSF14	90
KEGG	hsa05310	Asthma	16/1765	31/8135	0.0002349	0.001118	0.0006995	HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/HLA-DRA/HLA-DOB/HLA-DOA/FCER1G/CD40/TNF/CD40LG/HLA-DQA1/HLA-DRB4/FCER1A/HLA-DQB1/PRG2	16
KEGG	hsa05216	Thyroid cancer	18/1765	37/8135	0.0002538	0.001187	0.0007432	CDKN1A/GADD45A/GADD45B/MYC/TCF7L2/TCF7L1/PPARG/LEF1/GADD45G/DDB2/NCOA4/CCND1/TCF7/MAPK3/BAX/BAK1/MAPK1/PAX8	18
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	39/1765	106/8135	0.0002567	0.001187	0.0007432	CDKN1A/ADCY7/EGR1/JUND/NR4A2/PRKACB/PRKCB/ATF4/EGFR/VDR/HBEGF/TNFSF11/FOS/ARRB2/NACA/PLCB1/PDE4B/ADCY3/GNAI2/PLCB3/PTH1R/ITPR3/MEF2C/ARRB1/MMP13/GNA11/AKAP13/RAF1/FGF23/FGFR1/BCL2/GNA12/MAPK3/RHOA/PLCB4/MAPK1/LRP6/ITPR1/MEF2D	39
KEGG	hsa04670	Leukocyte transendothelial migration	41/1765	114/8135	0.0003162	0.001442	0.0009027	RAC2/NCF1/CYBB/THY1/PLCG2/ITGB2/ITGAM/ITGAL/PRKCB/VAV1/MAPK13/NCF4/JAM3/CXCL12/VASP/NCF2/RHOH/CYBA/ITGA4/ITK/PIK3CD/GNAI2/ACTB/CLDN5/MMP9/CXCR4/PIK3R1/RAPGEF3/VAV3/VCL/PTK2/ARHGAP35/RAP1B/PECAM1/MYL9/ROCK2/PIK3R3/RAC1/RHOA/PTK2B/CLDN7	41
KEGG	hsa05220	Chronic myeloid leukemia	30/1765	76/8135	0.0003226	0.001452	0.0009085	CDKN1A/GADD45A/GADD45B/MYC/SMAD3/NFKBIA/GRB2/GADD45G/DDB2/TGFB2/PIK3CD/ABL1/RELA/PIK3R1/HDAC1/CCND1/RB1/RAF1/MECOM/TGFBR2/TGFB3/PIK3R3/MAPK3/BAX/BAK1/MAPK1/BCR/CHUK/GAB2/CDKN1B	30
KEGG	hsa05144	Malaria	22/1765	50/8135	0.0003363	0.001493	0.0009347	SDC1/ITGB2/ITGAL/MYD88/THBS3/KLRB1/GYPC/TGFB2/CR1/CD40/IL1B/ACKR1/TNF/CD40LG/LRP1/COMP/THBS1/TGFB3/PECAM1/MET/IL6/THBS2	22
KEGG	hsa04621	NOD-like receptor signaling pathway	60/1765	184/8135	0.0003477	0.001523	0.0009534	TRAF3/CYBB/GABARAPL1/CASP1/CTSB/CCL5/FADD/TRPV2/JUN/OAS2/NFKBIA/PYCARD/PSTPIP1/MYD88/OAS1/MAPK13/GBP1/P2RX7/CARD8/IFNAR2/AIM2/IRF9/STAT1/CYBA/CASP8/HSP90AB1/PLCB1/MAP1LC3B/OAS3/NOD2/RELA/PLCB3/HSP90AA1/IL1B/NAMPT/TICAM1/TNF/ITPR3/CXCL2/NAIP/IKBKE/RBCK1/TRAF5/BIRC3/IRAK4/CXCL3/IFNA1/BCL2/PRKCD/MAPK3/IL6/RHOA/PLCB4/MAPK1/NLRP3/CHUK/TNFAIP3/CAMP/IRF7/ITPR1	60
KEGG	hsa04625	C-type lectin receptor signaling pathway	38/1765	104/8135	0.0003598	0.001556	0.000974	SYK/CLEC7A/CALML4/PLCG2/CASP1/JUN/NFKBIA/PYCARD/MAPK13/PTGS2/CBLB/IRF9/STAT1/CASP8/PIK3CD/RELA/FCER1G/EGR2/IL1B/PIK3R1/TNF/ITPR3/PLK3/IKBKE/EGR3/RRAS2/RAF1/MALT1/PIK3R3/PRKCD/MAPK3/IL6/RHOA/MAPK1/NLRP3/CHUK/PAK1/ITPR1	38
KEGG	hsa05134	Legionellosis	24/1765	57/8135	0.0004101	0.001751	0.001096	CASP1/ITGB2/ITGAM/CD14/NFKBIA/PYCARD/MYD88/BNIP3/HSPD1/CLK1/CASP8/BCL2L13/RELA/CR1/IL1B/TNF/CXCL2/NAIP/TLR5/CXCL3/IL6/CASP3/SAR1B/HSPA2	24
KEGG	hsa05100	Bacterial invasion of epithelial cells	30/1765	77/8135	0.0004205	0.001772	0.001109	ARPC1B/ARPC2/ARPC5/ACTR3/CLTC/WASL/RHOG/ARHGAP10/PIK3CD/ARPC1A/ACTR2/ITGA5/ARPC3/ACTB/PIK3R1/CAV2/CLTCL1/VCL/PTK2/WASF1/CTTN/PIK3R3/DOCK1/MET/RAC1/ARPC5L/RHOA/HCLS1/ARHGEF26/CLTA	30
KEGG	hsa04218	Cellular senescence	52/1765	156/8135	0.0004699	0.001956	0.001224	CDKN1A/GADD45A/GADD45B/MYC/CALML4/SMAD3/MAPK13/FOXO3/ATM/TRAF3IP2/FOXO1/PPP1CA/NBN/ZFP36L2/GADD45G/TGFB2/PIK3CD/PTEN/RELA/HLA-F/CDK1/CCNB2/CCNB1/MAP2K6/FOXM1/HLA-G/PIK3R1/ITPR3/HLA-B/ZFP36L1/HIPK3/HIPK2/PPP1CB/HLA-C/CCND1/SQSTM1/RRAS2/RB1/PPID/HLA-A/CCNE1/RAF1/CCNA2/TGFBR2/TGFB3/PIK3R3/MAPK3/IL6/CDK2/MAPK1/SLC25A6/ITPR1	52
KEGG	hsa04664	Fc epsilon RI signaling pathway	27/1765	68/8135	0.0005664	0.002329	0.001457	RAC2/SYK/LCP2/PLCG2/BTK/INPP5D/VAV1/LAT/ALOX5/MAPK13/GRB2/LYN/PIK3CD/PLA2G4C/FCER1G/MAP2K6/PIK3R1/TNF/VAV3/RAF1/PIK3R3/MAPK3/RAC1/FCER1A/MAPK1/GAB2/FYN	27
KEGG	hsa05212	Pancreatic cancer	29/1765	76/8135	0.000777	0.003149	0.001971	CDKN1A/GADD45A/RAC2/GADD45B/SMAD3/EGFR/ARHGEF6/STAT1/GADD45G/DDB2/TGFB2/PIK3CD/VEGFA/RALA/RELA/PIK3R1/CCND1/RB1/RAF1/TGFBR2/TGFB3/RPS6KB1/PIK3R3/MAPK3/RAC1/BAX/BAK1/MAPK1/CHUK	29
KEGG	hsa04144	Endocytosis	76/1765	251/8135	0.0007848	0.003149	0.001971	ARPC1B/ARPC2/CCR5/IL2RB/IL2RG/PARD3/SMAD3/ARPC5/CYTH4/WIPF1/ACTR3/EGFR/CBLB/FOLR2/ARAP1/CLTC/CAPZB/PSD4/ARRB2/ASAP3/IQSEC1/WASL/CAPZA1/ACAP1/CHMP1B/CYTH1/ARPC1A/RAB31/RAB8A/ACTR2/HLA-F/ARPC3/SNX6/LDLR/GRK6/BIN1/SH3GL1/CXCR4/HLA-G/HLA-B/GRK5/RAB11FIP1/ZFYVE9/AMPH/ARRB1/KIF5C/CAV2/CLTCL1/IGF2R/HLA-C/CAPZA2/STAM2/IGF1R/HLA-A/SMURF2/RAB11FIP5/TGFBR2/CHMP7/ZFYVE16/GIT2/AP2A2/PML/ARPC5L/RHOA/ACAP2/NEDD4L/VPS37C/WWP1/TFRC/CLTA/HSPA2/EHD2/SH3GLB1/ARF3/SPG21/AP2S1	76
KEGG	hsa04350	TGF-beta signaling pathway	34/1765	94/8135	0.0008859	0.003512	0.002198	MYC/ID4/SMAD3/TGIF1/ID2/SMAD7/INHBB/TGFB2/DCN/BMP4/ACVR2A/BMP5/TNF/ZFYVE9/CREBBP/SMURF2/TGFBR2/ACVR1B/ZFYVE16/THBS1/TGFB3/RPS6KB1/PPP2CB/TFDP1/SKP1/BMPR2/MAPK3/RHOA/MAPK1/PPP2R1B/BMP2/BMPR1A/FST/SMAD9	34
KEGG	hsa04610	Complement and coagulation cascades	31/1765	85/8135	0.001256	0.004888	0.003059	C6/C7/TFPI/CFD/ITGB2/ITGAM/C1QA/SERPING1/C2/SERPINA5/CFH/C3AR1/CR1/SERPINA1/C1QB/ITGAX/BDKRB2/F8/CD46/F2R/THBD/CD55/PLAT/C1R/F10/BDKRB1/C5/C5AR1/CFB/CLU/KLKB1	31
KEGG	hsa05224	Breast cancer	48/1765	147/8135	0.001262	0.004888	0.003059	CDKN1A/GADD45A/GADD45B/MYC/TCF7L2/TCF7L1/JUN/FZD2/HES1/EGFR/WNT11/FZD4/TNFSF11/GRB2/FGF2/FOS/FRAT2/FZD1/LEF1/GADD45G/DDB2/PIK3CD/WNT5B/PTEN/JAG1/WNT5A/NCOA1/PIK3R1/FZD10/CCND1/IGF1R/RB1/FGF4/NOTCH2/RAF1/NOTCH1/HEY2/RPS6KB1/FGF23/TCF7/FGFR1/WNT16/PIK3R3/MAPK3/BAX/BAK1/MAPK1/LRP6	48
KEGG	hsa05150	Staphylococcus aureus infection	34/1765	96/8135	0.001352	0.005174	0.003238	FCGR3B/HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/SELPLG/HLA-DRA/CFD/ITGB2/ITGAM/HLA-DOB/C1QA/ITGAL/PTAFR/C2/FCGR2B/HLA-DOA/FCGR2A/CFH/FPR3/C3AR1/FCGR2C/C1QB/HLA-DQA1/FPR1/C1R/KRT33A/HLA-DRB4/HLA-DQB1/CAMP/C5/C5AR1/KRT10/CFB	34
KEGG	hsa05213	Endometrial cancer	23/1765	58/8135	0.001447	0.005475	0.003427	CDKN1A/GADD45A/GADD45B/MYC/TCF7L2/TCF7L1/EGFR/FOXO3/GRB2/LEF1/GADD45G/DDB2/PIK3CD/PTEN/PIK3R1/CCND1/RAF1/TCF7/PIK3R3/MAPK3/BAX/BAK1/MAPK1	23
KEGG	hsa04932	Non-alcoholic fatty liver disease	49/1765	155/8135	0.002432	0.009098	0.005694	DDIT3/IRS2/JUN/ATF4/SOCS3/MAPK13/PPARG/ADIPOQ/XBP1/NR1H3/FOS/NDUFA3/CASP8/LEP/PIK3CD/UQCR11/RELA/SREBF1/IL1B/IRS1/NDUFS3/EIF2S1/PRKAA1/COX7A1/PIK3R1/TNF/BCL2L11/NDUFA9/NDUFB3/UQCRQ/NDUFB5/BID/CEBPA/EIF2AK3/UQCR10/NDUFA1/NDUFB11/ADIPOR2/NDUFB2/MLXIPL/FAS/PIK3R3/COX5A/IL6/RAC1/BAX/CASP3/COX7B/FASLG	49
KEGG	hsa04926	Relaxin signaling pathway	42/1765	129/8135	0.00262	0.009695	0.006068	ADCY7/EDNRB/COL3A1/COL1A2/PRKACB/MMP1/JUN/NFKBIA/ATF4/EGFR/MAPK13/GRB2/GNA15/GNG5/FOS/ARRB2/COL1A1/PLCB1/PIK3CD/VEGFA/ADCY3/GNAI2/RELA/PLCB3/VEGFC/MMP9/ACTA2/PIK3R1/COL4A6/ARRB1/MMP13/GNG12/RAF1/TGFBR2/GNG10/PIK3R3/GNB1/MAPK3/PLCB4/MAPK1/COL4A5/GNG7	42
KEGG	hsa04015	Rap1 signaling pathway	63/1765	210/8135	0.002712	0.009925	0.006212	RAC2/LCP2/ADCY7/MAGI2/CALML4/CSF1R/RASGRP3/DOCK4/ITGB2/ITGAM/EFNA5/PARD3/ITGAL/PRKCB/VAV1/LAT/EGFR/MAPK13/VASP/FGF2/PLCB1/EVL/TLN2/PIK3CD/VEGFA/RASGRP2/ADCY3/RALA/GNAI2/PLCB3/VEGFC/ACTB/MAP2K6/PRKD1/PFN1/PIK3R1/PDGFD/RAPGEF3/VAV3/IGF1R/FGF4/RAF1/LPAR1/PDGFC/F2R/THBS1/FPR1/RAP1B/FGF23/FGFR1/PIK3R3/MET/MAPK3/SIPA1L3/RAC1/RGS14/RHOA/PLCB4/MAPK1/LPAR2/PFN2/CSF1/KITLG	63
KEGG	hsa04110	Cell cycle	41/1765	126/8135	0.002961	0.01072	0.006707	CDKN1A/GADD45A/GADD45B/MYC/PTTG1/SMAD3/CDC20/ATM/MCM5/CCNH/GADD45G/MCM2/TGFB2/WEE1/ABL1/CDK1/CCNB2/CCNB1/PCNA/HDAC1/CREBBP/TTK/CCND1/RB1/CCNE1/CCNA2/ANAPC15/BUB1B/MAD2L1/TGFB3/ORC2/TFDP1/SKP1/CDC25B/CDC23/CDK2/CDC16/YWHAZ/CDKN1B/CDC6/STAG1	41
KEGG	hsa04141	Protein processing in endoplasmic reticulum	52/1765	171/8135	0.004509	0.01614	0.0101	PPP1R15A/DDIT3/DNAJB1/ATF4/SSR1/RPN2/SSR4/CRYAB/XBP1/BAG1/HSP90AB1/UBXN1/UGGT2/UBE2J1/HSP90AA1/PDIA3/WFS1/UGGT1/EIF2S1/DNAJC10/SEL1L/SEC24A/PDIA4/MAN1A1/SEC23B/DNAJA1/PDIA6/DERL1/ERP29/SEC61B/EDEM1/SEC63/EIF2AK3/EIF2AK2/SEC13/SSR3/NSFL1C/UBE2D3/HSPA5/SKP1/EDEM3/BCL2/BAX/BAK1/DERL2/SAR1B/DDOST/BAG2/HSPA2/UBE2G1/UBQLN2/SIL1	52
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	25/1765	70/8135	0.004909	0.01739	0.01089	CSK/PLCG2/CCL5/JUN/NFKBIA/EGFR/MAPK13/HBEGF/JAM3/LYN/ATP6V0E2/ATP6V1A/RELA/TJP1/ATP6V0B/CXCL2/TCIRG1/ATP6V1D/ATP6V0D1/CXCL3/MET/RAC1/CHUK/CASP3/PAK1	25
KEGG	hsa03250	Viral life cycle - HIV-1	23/1765	63/8135	0.005015	0.01758	0.011	MX2/CD4/APOBEC3G/MAP1B/CCR5/APOBEC3F/ELL2/SERINC5/NUP153/MX1/APOBEC3B/SAMHD1/CXCR4/CPSF7/APOBEC3C/CREBBP/RAN/SERINC3/RANBP2/FURIN/BICD2/CCNT1/TNPO3	23
KEGG	hsa05225	Hepatocellular carcinoma	51/1765	168/8135	0.005068	0.01758	0.011	CDKN1A/GADD45A/GADD45B/MYC/PLCG2/TCF7L2/TCF7L1/SMAD3/PRKCB/FZD2/EGFR/WNT11/FZD4/GRB2/FRAT2/FZD1/LEF1/GADD45G/DDB2/TGFB2/PIK3CD/NQO1/WNT5B/PTEN/ACTB/WNT5A/PIK3R1/FZD10/CCND1/IGF1R/RB1/RAF1/SMARCC2/TGFBR2/MGST3/TGFB3/RPS6KB1/TCF7/WNT16/PIK3R3/MET/MAPK3/BAX/BAK1/SMARCD3/MAPK1/GSTM2/GSTO1/SMARCD2/GSTM1/LRP6	51
KEGG	hsa04071	Sphingolipid signaling pathway	38/1765	119/8135	0.005865	0.02014	0.0126	RAC2/PRKCB/MAPK13/SGPL1/PLCB1/PIK3CD/PTEN/GNAI2/RELA/PLCB3/FCER1G/TRADD/S1PR4/PIK3R1/TNF/BDKRB2/PPP2R2A/BID/RAF1/PPP2CB/ROCK2/PIK3R3/BCL2/GNA12/MAPK3/RAC1/BAX/RHOA/PLCB4/FCER1A/MAPK1/PPP2R5C/PPP2R1B/GAB2/PPP2R2D/SGMS1/CERS2/FYN	38
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	27/1765	79/8135	0.007002	0.02379	0.01489	PLCG2/PRKCB/EGFR/FOXO3/GRB2/AXL/FGF2/PIK3CD/VEGFA/JAK2/PTEN/PIK3R1/PDGFD/BCL2L11/EIF4E2/IGF1R/RAF1/PDGFC/RPS6KB1/NRG2/PIK3R3/MET/BCL2/MAPK3/IL6/BAX/MAPK1	27
KEGG	hsa05218	Melanoma	25/1765	72/8135	0.0074	0.02489	0.01558	CDKN1A/GADD45A/GADD45B/EGFR/FGF2/GADD45G/DDB2/PIK3CD/PTEN/PIK3R1/PDGFD/CCND1/IGF1R/RB1/FGF4/RAF1/PDGFC/FGF23/FGFR1/PIK3R3/MET/MAPK3/BAX/BAK1/MAPK1	25
KEGG	hsa05203	Viral carcinogenesis	59/1765	204/8135	0.008568	0.02853	0.01786	CDKN1A/SYK/TRAF3/CCR5/PRKACB/JUN/CDC20/GSN/NFKBIA/ATF4/GRB2/LYN/IRF9/IL6ST/CASP8/GTF2E1/SNW1/PMAIP1/PIK3CD/RELA/HLA-F/EGR2/TRAF1/CDK1/TRADD/HLA-G/PIK3R1/HLA-B/EGR3/HDAC1/HNRNPK/CREBBP/GTF2B/HLA-C/CCND1/TRAF5/RB1/HLA-A/CCNE1/CCNA2/EIF2AK2/GTF2E2/ATP6V0D1/POLB/HDAC3/PIK3R3/SRF/MAPK3/RAC1/BAX/BAK1/RHOA/CDK2/MAPK1/CASP3/YWHAZ/IRF7/CDKN1B/USP7	59
KEGG	hsa04216	Ferroptosis	16/1765	41/8135	0.008796	0.029	0.01815	CYBB/ATG7/SLC39A14/SLC3A2/CP/MAP1LC3B/NCOA4/SLC39A8/GSS/ACSL5/TF/STEAP3/GPX4/TFRC/FTL/LPCAT3	16
KEGG	hsa05226	Gastric cancer	45/1765	149/8135	0.008981	0.02906	0.01819	CDKN1A/GADD45A/GADD45B/MYC/TCF7L2/TCF7L1/SMAD3/FZD2/EGFR/WNT11/FZD4/GRB2/FGF2/FRAT2/FZD1/LEF1/GADD45G/DDB2/TGFB2/PIK3CD/WNT5B/WNT5A/PIK3R1/FZD10/CCND1/RB1/FGF4/CCNE1/RAF1/TGFBR2/TGFB3/RPS6KB1/FGF23/TCF7/WNT16/PIK3R3/MET/BCL2/MAPK3/BAX/BAK1/CDK2/MAPK1/CDKN1B/LRP6	45
KEGG	hsa01524	Platinum drug resistance	25/1765	73/8135	0.008989	0.02906	0.01819	CDKN1A/TOP2A/FADD/REV3L/ATM/CASP8/PMAIP1/SLC31A1/PIK3CD/PIK3R1/BID/BIRC3/MGST3/FAS/PIK3R3/BCL2/MAPK3/BAX/BAK1/MAPK1/GSTM2/GSTO1/CASP3/FASLG/GSTM1	25
KEGG	hsa04722	Neurotrophin signaling pathway	37/1765	119/8135	0.01034	0.03312	0.02073	CALML4/PLCG2/RPS6KA1/ARHGDIB/JUN/NFKBIA/ATF4/SH2B3/MAPK13/FOXO3/NTRK2/GRB2/PIK3CD/MAPK7/ABL1/RELA/IRS1/PIK3R1/PSEN2/IRAK3/MAGED1/RAF1/MATK/IRAK4/RAP1B/PSEN1/PIK3R3/BCL2/PRKCD/MAPK3/RAC1/BAX/RHOA/MAPK1/FASLG/NFKBIE/IRAK1	37
KEGG	hsa04152	AMPK signaling pathway	37/1765	120/8135	0.01191	0.03777	0.02364	IRS2/PPARG/ADIPOQ/FOXO3/FOXO1/ACACB/FBP1/LEP/PCK1/PIK3CD/FASN/EEF2/SREBF1/RAB8A/PPARGC1A/SCD/LIPE/IRS1/PRKAA1/PFKFB3/PIK3R1/PPP2R2A/CAB39L/CCND1/IGF1R/CCNA2/RPS6KB1/PPP2CB/ADIPOR2/PIK3R3/ACACA/PPP2R5C/PPP2R1B/PPP2R2D/TBC1D1/ULK1/GYS2	37
KEGG	hsa05110	Vibrio cholerae infection	18/1765	50/8135	0.01437	0.04502	0.02817	PLCG2/PRKACB/KDELR3/ATP6V0E2/ATP6V1A/TJP2/ADCY3/KCNQ1/TJP1/ACTB/ATP6V0B/PDIA4/TCIRG1/SLC12A2/SEC61B/ATP6V1D/ATP6V0D1/KDELR2	18
KEGG	hsa04140	Autophagy - animal	42/1765	141/8135	0.01446	0.04502	0.02817	GABARAPL1/CTSB/IRS2/PRKACB/ATG7/BNIP3/DDIT4/RRAGA/RRAGC/MAP1LC3B/PIK3CD/PTEN/RAB8A/LAMP2/VAMP8/IRS1/EIF2S1/UVRAG/PRKAA1/RRAGB/PIK3R1/PRKCQ/MTMR14/ATG2A/RB1CC1/IGF1R/SQSTM1/RRAS2/ATG4A/RAF1/EIF2AK3/CTSL/RPS6KB1/PPP2CB/PIK3R3/BCL2/PRKCD/MAPK3/MAPK1/SH3GLB1/ULK1/ITPR1	42
KEGG	hsa05223	Non-small cell lung cancer	24/1765	72/8135	0.01476	0.04514	0.02825	CDKN1A/GADD45A/GADD45B/PLCG2/PRKCB/EGFR/FOXO3/GRB2/GADD45G/DDB2/PIK3CD/ALK/PIK3R1/KIF5C/EML4/CCND1/RB1/RAF1/PIK3R3/MET/MAPK3/BAX/BAK1/MAPK1	24
KEGG	hsa04390	Hippo signaling pathway	46/1765	157/8135	0.01477	0.04514	0.02825	SAV1/MYC/TCF7L2/ITGB2/TCF7L1/PARD3/SMAD3/FZD2/WNT11/FZD4/ID2/SMAD7/PPP1CA/FZD1/LEF1/YAP1/TGFB2/DLG5/WNT5B/BMP4/ACTB/WNT5A/BMP5/FZD10/LLGL2/STK3/PPP1CB/PPP2R2A/CCND1/AREG/TEAD1/MOB1A/BIRC3/TGFBR2/TGFB3/TEAD3/PPP2CB/TCF7/WNT16/BMPR2/PPP2R1B/BMP2/BMPR1A/PPP2R2D/SNAI2/YWHAZ	46
KEGG	hsa04270	Vascular smooth muscle contraction	40/1765	134/8135	0.01612	0.04881	0.03055	ADCY7/ADM/CALML4/AGTR1/PRKACB/PRKCB/PLA2G2D/MYH11/PPP1CA/PLCB1/RAMP2/NPR2/PLA2G4C/ADCY3/PLCB3/ACTA2/MYLK/ITPR3/PRKCQ/KCNMB1/PPP1CB/NPR1/GNA11/CALCRL/RAF1/MYL9/ROCK2/PLA2G2F/GNA12/PRKCD/MAPK3/RHOA/PLCB4/CALD1/MAPK1/PRKCH/PPP1R12A/ACTG2/PLA2G2A/ITPR1	40
KEGG	hsa04630	JAK-STAT signaling pathway	47/1765	162/8135	0.0166	0.0498	0.03117	CDKN1A/PTPN6/MYC/IL7R/IL2RB/SOCS2/IL2RG/IL27RA/GHR/IL21R/SOCS3/EGFR/AOX1/PIM1/IL10RA/CSF2RB/GRB2/IFNAR2/IL15/IRF9/STAT1/IL6ST/LEP/IL12RB1/PIK3CD/JAK2/IL15RA/LIFR/CSF2RA/IL10RB/CSF3R/STAT4/PIK3R1/CREBBP/CCND1/IFNGR2/STAM2/RAF1/PIAS1/IL7/PIK3R3/IFNA1/BCL2/IL6/LIF/IL12RB2/STAT6	47
KEGG	hsa00562	Inositol phosphate metabolism	24/1765	73/8135	0.01758	0.05228	0.03272	PLCG2/INPP5D/INPP5A/ITPKC/FIG4/INPP4A/PLCB1/ITPKB/PIK3CD/PTEN/MTMR1/PLCB3/PIK3CG/MINPP1/MTMR14/ALDH6A1/MTMR2/IMPA2/INPP4B/INPP1/PLCB4/ISYNA1/SYNJ2/SACM1L	24
KEGG	hsa01523	Antifolate resistance	12/1765	30/8135	0.01784	0.05257	0.0329	TYMS/GGH/ABCC4/FOLR2/RELA/ABCC3/IL1B/TNF/SHMT2/IL6/CHUK/ABCC5	12
KEGG	hsa04371	Apelin signaling pathway	41/1765	139/8135	0.01835	0.05359	0.03354	ADCY7/KLF2/CALML4/EGR1/AGTR1/APLNR/PRKACB/SMAD3/PLIN1/GNG5/PLCB1/MAP1LC3B/TFAM/ADCY3/JAG1/GNAI2/PLCB3/PPARGC1A/SLC8A1/PIK3CG/LIPE/PRKAA1/ACTA2/MYLK/ITPR3/MEF2C/SPP1/GNG12/CCND1/RRAS2/RAF1/RPS6KB1/PLAT/GNG10/GNB1/MAPK3/PLCB4/MAPK1/GNG7/ITPR1/MEF2D	41
KEGG	hsa04022	cGMP-PKG signaling pathway	48/1765	167/8135	0.01854	0.05367	0.03359	ADCY7/EDNRB/CALML4/AGTR1/IRS2/ATF4/VASP/ATP2A3/PPP1CA/GTF2IRD1/PLCB1/RGS2/NPR2/ADCY3/GNAI2/PLCB3/SLC8A1/PLN/PIK3CG/IRS1/PDE2A/ATP1A1/MYLK/ITPR3/MEF2C/KCNMB1/BDKRB2/ADRA2A/PPP1CB/NPR1/GNA11/RAF1/MYL9/ROCK2/SRF/GNA12/MAPK3/RHOA/ADRA2C/PLCB4/MAPK1/ATP2B4/PPP1R12A/PPIF/SLC25A6/ATP1A2/ITPR1/MEF2D	48
KEGG	hsa05217	Basal cell carcinoma	21/1765	63/8135	0.02167	0.06221	0.03894	CDKN1A/GADD45A/GADD45B/TCF7L2/TCF7L1/FZD2/WNT11/FZD4/FZD1/LEF1/GADD45G/DDB2/WNT5B/BMP4/WNT5A/FZD10/TCF7/WNT16/BAX/BAK1/BMP2	21
KEGG	hsa04910	Insulin signaling pathway	40/1765	137/8135	0.02316	0.06592	0.04126	CALML4/SORBS1/SOCS2/HK3/IRS2/PRKACB/SOCS3/INPP5A/CBLB/FOXO1/GRB2/ACACB/PPP1CA/FBP1/PCK1/PIK3CD/FASN/PPP1R3C/SREBF1/PPARGC1A/LIPE/IRS1/MKNK2/PRKAA1/PIK3R1/MKNK1/TRIP10/RHOQ/PPP1CB/EIF4E2/RAF1/RPS6KB1/PHKA1/PIK3R3/MAPK3/ACACA/MAPK1/PHKB/PTPRF/GYS2	40
KEGG	hsa04929	GnRH secretion	21/1765	64/8135	0.02585	0.07295	0.04566	PRKCB/ARRB2/PLCB1/PIK3CD/KCNN4/PLCB3/PIK3R1/ITPR3/SPP1/ARRB1/GNA11/KCNN3/RAF1/PIK3R3/TRPC1/MAPK3/KCNJ5/PLCB4/MAPK1/GPER1/ITPR1	21
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/1765	15/8135	0.02763	0.07731	0.04839	NAGA/B3GALNT1/HEXB/A4GALT/ST8SIA1/ST3GAL2/HEXA	7
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	41/1765	143/8135	0.02902	0.08053	0.0504	KLF4/MYC/ID4/SMAD3/FZD2/MAPK13/WNT11/FZD4/ID2/GRB2/FGF2/ZFHX3/INHBB/FZD1/IL6ST/PIK3CD/WNT5B/JAK2/BMP4/LIFR/ACVR2A/WNT5A/PIK3R1/TBX3/FZD10/IGF1R/RAF1/ACVR1B/TCF7/FGFR1/WNT16/BMPR2/PIK3R3/MAPK3/PCGF3/LIF/MAPK1/BMPR1A/KAT6A/PCGF2/SMAD9	41
KEGG	hsa04512	ECM-receptor interaction	27/1765	88/8135	0.03055	0.08338	0.05218	SDC1/COL1A2/SDC4/LAMA2/THBS3/ITGA4/COL1A1/LAMA4/LAMA3/ITGA10/ITGA5/LAMC1/CD47/SPP1/COL4A6/LAMA5/ITGB7/LAMC3/ITGA7/LAMC2/COMP/THBS1/LAMB2/COL4A5/AGRN/THBS2/HMMR	27
KEGG	hsa04540	Gap junction	27/1765	88/8135	0.03055	0.08338	0.05218	ADCY7/PRKACB/PRKCB/EGFR/GRB2/PLCB1/ADCY3/MAPK7/GNAI2/PLCB3/TJP1/CDK1/TUBA1A/PDGFD/ITPR3/TUBA4A/GNA11/RAF1/LPAR1/TUBA1B/PDGFC/TUBA1C/MAPK3/PLCB4/MAPK1/DRD1/ITPR1	27
KEGG	hsa05211	Renal cell carcinoma	22/1765	69/8135	0.03165	0.08569	0.05363	CDKN1A/JUN/GRB2/TGFB2/PIK3CD/VEGFA/PIK3R1/CREBBP/RAF1/TGFB3/EGLN1/TFE3/RAP1B/PAK2/SLC2A1/PIK3R3/MET/MAPK3/RAC1/MAPK1/ARNT/PAK1	22
KEGG	hsa04072	Phospholipase D signaling pathway	42/1765	148/8135	0.0322	0.0858	0.0537	SYK/ADCY7/PLCG2/AGTR1/CYTH4/EGFR/GRB2/PLCB1/CYTH1/PIK3CD/AGPAT4/PLA2G4C/ADCY3/RALA/PLCB3/DGKZ/FCER1G/PIK3CG/PIK3R1/PDGFD/RAPGEF3/RRAS2/RAF1/LPAR1/LPAR6/GRM6/PDGFC/F2R/PIK3R3/GNA12/MAPK3/RHOA/PLCB4/FCER1A/MAPK1/DGKA/PTK2B/GRM3/LPAR2/GAB2/KITLG/FYN	42
KEGG	hsa04931	Insulin resistance	32/1765	108/8135	0.03221	0.0858	0.0537	RPS6KA1/IRS2/PRKCB/NFKBIA/SOCS3/FOXO1/NR1H3/ACACB/PPP1CA/PCK1/PIK3CD/PTEN/PPP1R3C/RELA/SREBF1/PPARGC1A/IRS1/PRKAA1/PIK3R1/TNF/PRKCQ/SLC27A3/PPP1CB/TRIB3/RPS6KB1/SLC2A1/MLXIPL/PIK3R3/PRKCD/IL6/PTPRF/GYS2	32
KEGG	hsa04066	HIF-1 signaling pathway	32/1765	109/8135	0.03641	0.09622	0.06023	CDKN1A/CYBB/PLCG2/HK3/TIMP1/PRKCB/EGFR/PIK3CD/VEGFA/RELA/LDHB/TF/MKNK2/PFKFB3/PIK3R1/MKNK1/CREBBP/EIF4E2/IFNGR2/IGF1R/LDHA/EGLN1/RPS6KB1/SLC2A1/PIK3R3/BCL2/MAPK3/IL6/MAPK1/TFRC/ARNT/CDKN1B	32
KEGG	hsa04014	Ras signaling pathway	62/1765	232/8135	0.03791	0.0994	0.06221	RAC2/CALML4/PLCG2/CSF1R/RASGRP3/RASGRP1/EFNA5/PRKACB/PRKCB/LAT/EGFR/PLA2G2D/NTRK2/ETS2/GRB2/ZAP70/GNG5/FGF2/PIK3CD/VEGFA/PLA2G4C/RASGRP2/RALA/ABL1/RELA/RASA1/VEGFC/PIK3R1/PDGFD/GNG12/IGF1R/EXOC2/RRAS2/FGF4/RAF1/RGL2/RGL1/PDGFC/ABL2/RAP1B/FGF23/BRAP/FGFR1/PAK2/GNG10/FOXO4/PIK3R3/MET/PLA2G2F/GNB1/MAPK3/RAC1/RHOA/MAPK1/CHUK/GAB2/PAK1/FASLG/CSF1/KITLG/PLA2G2A/GNG7	62
KEGG	hsa01522	Endocrine resistance	29/1765	98/8135	0.04065	0.1058	0.06619	CDKN1A/ADCY7/PRKACB/JUN/EGFR/MAPK13/HBEGF/GRB2/FOS/PIK3CD/ADCY3/JAG1/MMP9/PIK3R1/CCND1/IGF1R/RB1/NOTCH2/PTK2/RAF1/NOTCH1/RPS6KB1/PIK3R3/BCL2/MAPK3/BAX/MAPK1/GPER1/CDKN1B	29
KEGG	hsa05143	African trypanosomiasis	13/1765	37/8135	0.04216	0.1088	0.06812	PRKCB/MYD88/APOL1/LAMA4/PLCB1/IDO1/PLCB3/IL1B/TNF/FAS/IL6/PLCB4/FASLG	13
KEGG	hsa04934	Cushing syndrome	43/1765	155/8135	0.04329	0.1109	0.0694	CDKN1A/ADCY7/TCF7L2/AGTR1/TCF7L1/NR4A1/PRKACB/FZD2/ATF4/EGFR/KCNK3/WNT11/FZD4/FZD1/LEF1/PLCB1/WNT5B/ADCY3/GNAI2/PLCB3/AHR/LDLR/WNT5A/ITPR3/FZD10/CCND1/GNA11/RB1/CCNE1/PBX1/CYP11A1/RAP1B/TCF7/WNT16/MAPK3/PDE8B/PLCB4/CDK2/MAPK1/ARNT/PDE8A/CDKN1B/ITPR1	43
KEGG	hsa03320	PPAR signaling pathway	23/1765	75/8135	0.04375	0.1112	0.0696	FABP4/SORBS1/MMP1/PLIN1/PPARG/ADIPOQ/PLIN2/LPL/NR1H3/UBC/PCK1/ACSL5/SCD/ACADL/ME1/OLR1/HMGCS1/ANGPTL4/PLTP/FABP5/FABP3/ACAA1/EHHADH	23
KEGG	hsa05219	Bladder cancer	14/1765	41/8135	0.0452	0.1135	0.07104	CDKN1A/MYC/MMP1/EGFR/HBEGF/VEGFA/MMP9/CCND1/RB1/RAF1/THBS1/MAPK3/MAPK1/TYMP	14
KEGG	hsa04923	Regulation of lipolysis in adipocytes	18/1765	56/8135	0.04534	0.1135	0.07104	ADCY7/FABP4/IRS2/PRKACB/PLIN1/PTGS2/PNPLA2/NPY1R/PIK3CD/ADCY3/ABHD5/GNAI2/LIPE/IRS1/PIK3R1/NPR1/PTGS1/PIK3R3	18
KEGG	hsa04978	Mineral absorption	19/1765	60/8135	0.04672	0.1161	0.07267	MT1HL1/MT1X/MT1E/MT1H/ATOX1/MT1M/MT1G/MT2A/VDR/MT1F/SLC31A1/SLC8A1/TF/ATP1A1/CYBRD1/ATP2B4/FTL/ATP1A2/SLC26A3	19
KEGG	hsa04150	mTOR signaling pathway	43/1765	156/8135	0.04763	0.1175	0.07354	GRB10/RPS6KA1/PRKCB/FZD2/WNT11/FZD4/GRB2/DDIT4/RRAGA/RRAGC/SLC3A2/FZD1/ATP6V1A/CLIP1/PIK3CD/WNT5B/PTEN/IRS1/WNT5A/PRKAA1/RRAGB/PIK3R1/TNF/LAMTOR2/FZD10/EIF4E2/CAB39L/IGF1R/RAF1/ATP6V1D/LPIN1/SEC13/RPS6KB1/WNT16/PIK3R3/MAPK3/RHOA/MAPK1/CHUK/EIF4B/LRP6/ULK1/WDR59	43
KEGG	hsa04530	Tight junction	46/1765	169/8135	0.05056	0.1238	0.07748	ARPC1B/ARPC2/ARHGEF18/PARD3/PRKACB/YBX3/JUN/ARPC5/WAS/ACTR3/JAM3/MYH11/MPDZ/VASP/TJP2/AMOTL2/ARPC1A/RAB8A/TJP1/ACTR2/ARPC3/ACTB/CLDN5/TUBA1A/PRKAA1/PCNA/TUBA4A/LLGL2/MICALL2/PPP2R2A/CCND1/TUBA1B/CTTN/EPB41L4B/PPP2CB/MYL9/ROCK2/TUBA1C/RAC1/ARPC5L/RHOA/NEDD4L/HCLS1/PPP2R1B/PPP2R2D/CLDN7	46
KEGG	hsa03013	Nucleocytoplasmic transport	31/1765	108/8135	0.05165	0.1249	0.07819	EIF4A3/NXF1/NUP62/NUP210/AHCTF1/NXT1/UPF3A/SRRM1/NUP153/NUP37/POM121C/NUP43/PNN/RAN/NUP50/KPNA2/XPO6/NCBP1/SNUPN/SEC13/SUMO4/RANBP2/UPF1/SAP18/NUP155/IPO5/NUP54/TNPO3/KPNA3/RNPS1/UPF2	31
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/1765	53/8135	0.05177	0.1249	0.07819	PRKACB/PRKCB/VDR/CLTC/PLCB1/PLCB3/SLC8A1/PTH1R/ATP1A1/BDKRB2/CLTCL1/AP2A2/PLCB4/ATP2B4/CLTA/ATP1A2/AP2S1	17
KEGG	hsa04360	Axon guidance	49/1765	182/8135	0.05316	0.1274	0.07971	RAC2/SEMA4D/PLCG2/EFNA5/ABLIM1/PARD3/PLXNA1/SEMA4A/CXCL12/EFNB2/CDK5/SEMA3E/PLXNC1/PIK3CD/EPHB2/WNT5B/ABL1/GNAI2/SEMA3G/RASA1/UNC5C/SEMA3C/RND1/WNT5A/CXCR4/PIK3R1/PTK2/RAF1/PLXNB2/RGS3/NRP1/MYL9/ROCK2/PAK2/LRIG2/BMPR2/PIK3R3/MET/TRPC1/MAPK3/RAC1/RYK/RHOA/MAPK1/EPHB3/SEMA4C/SEMA3B/PAK1/FYN	49
KEGG	hsa04920	Adipocytokine signaling pathway	21/1765	69/8135	0.05639	0.134	0.08386	IRS2/NFKBIA/SOCS3/ADIPOQ/ACACB/LEP/PCK1/JAK2/ACSL5/RELA/PPARGC1A/IRS1/TRADD/PRKAA1/TNF/PRKCQ/TNFRSF1B/ADIPOR2/SLC2A1/CHUK/NFKBIE	21
KEGG	hsa04919	Thyroid hormone signaling pathway	34/1765	121/8135	0.05673	0.134	0.08386	MYC/PLCG2/PRKACB/PRKCB/FOXO1/STAT1/ATP2A3/DIO3/PLCB1/PIK3CD/RCAN2/BMP4/PLCB3/PLN/ACTB/NCOA1/ATP1A1/PIK3R1/MED13L/HDAC1/CREBBP/THRB/CCND1/NOTCH2/RAF1/NOTCH1/SLC2A1/HDAC3/PIK3R3/MAPK3/PLCB4/MAPK1/THRA/ATP1A2	34
KEGG	hsa04012	ErbB signaling pathway	25/1765	85/8135	0.05811	0.1357	0.08495	CDKN1A/MYC/PLCG2/JUN/PRKCB/EGFR/CBLB/HBEGF/GRB2/PIK3CD/ABL1/EREG/PIK3R1/AREG/PTK2/RAF1/RPS6KB1/ABL2/NRG2/PAK2/PIK3R3/MAPK3/MAPK1/PAK1/CDKN1B	25
KEGG	hsa04912	GnRH signaling pathway	27/1765	93/8135	0.05828	0.1357	0.08495	ADCY7/CALML4/EGR1/PRKACB/JUN/PRKCB/ATF4/EGFR/MAPK13/HBEGF/GRB2/PLCB1/PLA2G4C/ADCY3/MAPK7/PLCB3/MAP2K6/ITPR3/GNA11/RAF1/MAP3K4/PRKCD/MAPK3/PLCB4/MAPK1/PTK2B/ITPR1	27
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	28/1765	98/8135	0.06528	0.151	0.09448	ADCY7/CALML4/PLCG2/TRPV2/PRKACB/PRKCB/MAPK13/PPP1CA/PLCB1/PIK3CD/PLA2G4C/ADCY3/IL1R1/PLCB3/IL1B/MAP2K6/PIK3R1/ITPR3/PRKCQ/BDKRB2/PPP1CB/PIK3R3/PRKCD/PLCB4/P2RY2/PRKCH/BDKRB1/ITPR1	28
KEGG	hsa00620	Pyruvate metabolism	15/1765	47/8135	0.06777	0.1556	0.09741	ADH1B/ADH1C/AKR1A1/ACACB/ME2/PCK1/ADH5/LDHB/ACAT2/PC/ME1/ACAT1/ALDH2/LDHA/ACACA	15
KEGG	hsa04935	Growth hormone synthesis, secretion and action	33/1765	119/8135	0.07008	0.1598	0.1	ADCY7/PLCG2/JUNB/SOCS2/IRS2/PRKACB/PRKCB/GHR/ATF4/SOCS3/MAPK13/GRB2/STAT1/FOS/PLCB1/PIK3CD/ADCY3/JAK2/GNAI2/PLCB3/IRS1/MAP2K6/PIK3R1/ITPR3/CREBBP/GNA11/PTK2/RAF1/PIK3R3/MAPK3/PLCB4/MAPK1/ITPR1	33
KEGG	hsa04370	VEGF signaling pathway	18/1765	59/8135	0.07203	0.1632	0.1021	RAC2/PLCG2/PRKCB/MAPK13/PTGS2/MAPKAPK3/PIK3CD/VEGFA/PLA2G4C/HSPB1/SH2D2A/PIK3R1/PTK2/RAF1/PIK3R3/MAPK3/RAC1/MAPK1	18
KEGG	hsa05214	Glioma	22/1765	75/8135	0.07403	0.1666	0.1043	CDKN1A/GADD45A/GADD45B/CALML4/PLCG2/PRKCB/EGFR/GRB2/GADD45G/DDB2/PIK3CD/PTEN/PIK3R1/CCND1/IGF1R/RB1/RAF1/PIK3R3/MAPK3/BAX/BAK1/MAPK1	22
KEGG	hsa04921	Oxytocin signaling pathway	41/1765	154/8135	0.08317	0.1859	0.1163	CDKN1A/ADCY7/CALML4/PRKACB/JUN/PRKCB/CD38/EGFR/PTGS2/FOS/PPP1CA/PLCB1/RGS2/NPR2/PLA2G4C/EEF2/ADCY3/MAPK7/GNAI2/PLCB3/CACNB2/PIK3CG/ACTB/PRKAA1/MYLK/ITPR3/MEF2C/PPP1CB/NPR1/CCND1/KCNJ2/RAF1/MYL9/ROCK2/MAPK3/KCNJ5/RHOA/PLCB4/MAPK1/PPP1R12A/ITPR1	41
KEGG	hsa04137	Mitophagy - animal	21/1765	72/8135	0.08376	0.1859	0.1164	GABARAPL1/JUN/ATF4/FOXO3/BNIP3/UBC/MAP1LC3B/BCL2L13/CITED2/CALCOCO2/RELA/PINK1/TBC1D15/BNIP3L/CSNK2A2/SQSTM1/RRAS2/EIF2AK3/RPS27A/TFE3/ULK1	21
KEGG	hsa04310	Wnt signaling pathway	44/1765	167/8135	0.08612	0.1899	0.1189	RAC2/SFRP1/MYC/TCF7L2/TCF7L1/PRKACB/DAAM2/SMAD3/JUN/PRKCB/FZD2/WNT11/FZD4/FRAT2/FZD1/LEF1/PLCB1/WNT5B/NLK/PLCB3/LGR4/CACYBP/WNT5A/SOX17/SIAH1/TLE2/FZD10/CSNK2A2/CREBBP/CCND1/TLE1/WIF1/PSEN1/TCF7/ROCK2/SKP1/WNT16/RAC1/RYK/RHOA/PLCB4/GPC4/SFRP4/LRP6	44
KEGG	hsa04217	Necroptosis	42/1765	159/8135	0.08888	0.1947	0.1219	CYBB/CASP1/FADD/PYCARD/PARP1/IFNAR2/IRF9/STAT1/TNFSF10/CASP8/CHMP1B/HSP90AB1/PLA2G4C/JAK2/HSP90AA1/IL1B/TRADD/STAT4/TICAM1/TNF/TLR3/RBCK1/IFNGR2/TRAF5/FAF1/SQSTM1/PPID/BID/BIRC3/EIF2AK2/CHMP7/FAS/IFNA1/BCL2/BAX/NLRP3/TNFAIP3/FTL/FASLG/SLC25A6/SPATA2/STAT6	42
KEGG	hsa04070	Phosphatidylinositol signaling system	27/1765	97/8135	0.09078	0.1976	0.1237	CALML4/PLCG2/INPP5D/PRKCB/INPP5A/ITPKC/INPP4A/PLCB1/ITPKB/PIK3CD/PTEN/MTMR1/PLCB3/DGKZ/PIK3R1/ITPR3/MTMR14/MTMR2/IMPA2/INPP4B/PIK3R3/INPP1/PLCB4/DGKA/SYNJ2/ITPR1/SACM1L	27
KEGG	hsa00531	Glycosaminoglycan degradation	7/1765	19/8135	0.09707	0.2099	0.1314	HPSE/HEXB/HYAL1/ARSB/GNS/HEXA/GUSB	7
KEGG	hsa04972	Pancreatic secretion	28/1765	102/8135	0.09933	0.2134	0.1336	ADCY7/PRKCB/CD38/PLA2G2D/ATP2A3/PLCB1/ADCY3/KCNQ1/PLCB3/RAB8A/CPB1/ATP1A1/ITPR3/SLC12A2/RAP1B/CA2/PLA2G2F/TRPC1/RAC1/RHOA/PLCB4/SCT/ATP2B4/BST1/ATP1A2/PLA2G2A/ITPR1/SLC26A3	28
KEGG	hsa05415	Diabetic cardiomyopathy	52/1765	203/8135	0.1008	0.2152	0.1347	RAC2/NCF1/CYBB/AGTR1/COL3A1/COL1A2/SMAD3/PRKCB/MAPK13/NCF4/PARP1/ATP2A3/NCF2/PPP1CA/CYBA/NDUFA3/COL1A1/PLCB1/TGFB2/PIK3CD/PTEN/UQCR11/RELA/PDK4/PLCB3/PLN/IRS1/NDUFS3/MMP9/COX7A1/PIK3R1/NDUFA9/NDUFB3/UQCRQ/PPP1CB/NDUFB5/UQCR10/TGFBR2/NDUFA1/TGFB3/NDUFB11/NDUFB2/SLC2A1/PIK3R3/COX5A/PRKCD/RAC1/PLCB4/COX7B/PPIF/SLC25A6/GYS2	52
KEGG	hsa00380	Tryptophan metabolism	13/1765	42/8135	0.1047	0.2221	0.139	MAOA/KMO/AOX1/KYNU/TDO2/IDO1/ACAT2/ACAT1/ALDH2/GCDH/AOC1/MAOB/EHHADH	13
KEGG	hsa04728	Dopaminergic synapse	35/1765	132/8135	0.1077	0.2271	0.1421	CALML4/PRKACB/PRKCB/ATF4/MAOA/MAPK13/GNG5/FOS/PPP1CA/ARRB2/SLC6A3/PLCB1/COMT/GNAI2/PLCB3/ARNTL/ITPR3/ARRB1/KIF5C/PPP1CB/PPP2R2A/GNG12/PPP2CB/GNG10/MAOB/GNB1/KCNJ5/PLCB4/PPP2R5C/PPP2R1B/PPP2R2D/GNAL/DRD1/GNG7/ITPR1	35
KEGG	hsa00430	Taurine and hypotaurine metabolism	6/1765	16/8135	0.1125	0.2355	0.1474	FMO2/CDO1/GGT5/FMO1/ADO/GAD1	6
KEGG	hsa04710	Circadian rhythm	10/1765	31/8135	0.1155	0.2403	0.1504	PER3/RORA/CRY2/BHLHE40/PRKAA1/ARNTL/NPAS2/CRY1/PER2/SKP1	10
KEGG	hsa04330	Notch signaling pathway	17/1765	59/8135	0.1221	0.2526	0.1581	HES1/SNW1/ATXN1/JAG1/TLE2/PSEN2/HDAC1/CREBBP/NOTCH2/APH1B/TLE1/MFNG/NOTCH1/HEY2/PSEN1/NCSTN/PTCRA	17
KEGG	hsa04916	Melanogenesis	27/1765	101/8135	0.1335	0.2736	0.1713	ADCY7/EDNRB/CALML4/TCF7L2/TCF7L1/PRKACB/PRKCB/FZD2/WNT11/FZD4/FZD1/LEF1/PLCB1/WNT5B/ADCY3/GNAI2/PLCB3/WNT5A/FZD10/CREBBP/RAF1/TCF7/WNT16/MAPK3/PLCB4/MAPK1/KITLG	27
KEGG	hsa00650	Butanoate metabolism	9/1765	28/8135	0.1339	0.2736	0.1713	ACAT2/BDH2/ACSM5/HMGCS1/ACAT1/GAD1/ALDH5A1/AACS/EHHADH	9
KEGG	hsa00640	Propanoate metabolism	10/1765	32/8135	0.1369	0.2761	0.1728	ACACB/ACSS3/LDHB/BCKDHB/HIBCH/ALDH6A1/PCCB/LDHA/ACACA/EHHADH	10
KEGG	hsa04215	Apoptosis - multiple species	10/1765	32/8135	0.1369	0.2761	0.1728	FADD/CASP8/PMAIP1/BCL2L11/BID/BIRC3/BCL2/BAX/BAK1/CASP3	10
KEGG	hsa04730	Long-term depression	17/1765	60/8135	0.1377	0.2761	0.1728	PRKCB/LYN/PLCB1/PLA2G4C/GNAI2/PLCB3/ITPR3/GNA11/IGF1R/RAF1/PPP2CB/GNA12/MAPK3/PLCB4/MAPK1/PPP2R1B/ITPR1	17
KEGG	hsa00350	Tyrosine metabolism	11/1765	36/8135	0.1387	0.2767	0.1732	ADH1B/ADH1C/AOC3/MAOA/AOX1/ADH5/COMT/AOC2/FAH/PNMT/MAOB	11
KEGG	hsa00280	Valine, leucine and isoleucine degradation	14/1765	48/8135	0.14	0.2774	0.1736	AOX1/ACAT2/BCKDHB/HMGCS1/ACAT1/HIBCH/ALDH2/ALDH6A1/PCCB/AUH/AACS/ACAA1/BCAT2/EHHADH	14
KEGG	hsa04914	Progesterone-mediated oocyte maturation	27/1765	102/8135	0.1458	0.2872	0.1798	ADCY7/STK10/RPS6KA1/PRKACB/MAPK13/HSP90AB1/PIK3CD/ADCY3/GNAI2/HSP90AA1/CDK1/CCNB2/CCNB1/PIK3R1/IGF1R/RAF1/CCNA2/ANAPC15/MAD2L1/PIK3R3/CDC25B/MAPK3/CDC23/CDK2/MAPK1/CDC16/CPEB1	27
KEGG	hsa04925	Aldosterone synthesis and secretion	26/1765	98/8135	0.1483	0.2888	0.1808	ADCY7/CALML4/AGTR1/NR4A2/NR4A1/PRKACB/PRKCB/ATF4/KCNK3/PLCB1/ADCY3/PLCB3/LDLR/LIPE/PDE2A/PRKD1/ATP1A1/ITPR3/NPR1/GNA11/CYP11A1/KCNJ5/PLCB4/ATP2B4/ATP1A2/ITPR1	26
KEGG	hsa05231	Choline metabolism in cancer	26/1765	98/8135	0.1483	0.2888	0.1808	RAC2/WASF3/JUN/PRKCB/WAS/EGFR/GRB2/FOS/PIK3CD/CHPT1/PLA2G4C/CHKA/DGKZ/LYPLA1/PIK3R1/PDGFD/RAF1/WASF1/PDGFC/RPS6KB1/SLC44A1/PIK3R3/MAPK3/RAC1/MAPK1/DGKA	26
KEGG	hsa04927	Cortisol synthesis and secretion	18/1765	65/8135	0.1524	0.2935	0.1837	ADCY7/AGTR1/NR4A1/PRKACB/ATF4/KCNK3/PLCB1/ADCY3/PLCB3/LDLR/ITPR3/GNA11/PBX1/CYP11A1/PDE8B/PLCB4/PDE8A/ITPR1	18
KEGG	hsa00920	Sulfur metabolism	4/1765	10/8135	0.1525	0.2935	0.1837	PAPSS1/ETHE1/MPST/PAPSS2	4
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	55/1765	223/8135	0.1568	0.3	0.1878	NCF1/JUN/NFKBIA/EGFR/AKR1A1/MAPK13/FOXO3/GRB2/AKR1C1/FOS/NCF2/CYBA/NDUFA3/CBR1/PIK3CD/VEGFA/NQO1/PTEN/UQCR11/ABL1/RELA/AHR/NDUFS3/PRKD1/COX7A1/PIK3R1/NOX4/NDUFA9/NDUFB3/UQCRQ/NDUFB5/PTK2/RAF1/UQCR10/MGST3/NDUFA1/ABL2/NDUFB11/CYP2F1/NDUFB2/PIK3R3/MET/COX5A/PRKCD/MAPK3/RAC1/MAPK1/GSTM2/GSTO1/CHUK/ARNT/COX7B/PPIF/SLC25A6/GSTM1	55
KEGG	hsa04392	Hippo signaling pathway - multiple species	9/1765	29/8135	0.1588	0.3006	0.1882	SAV1/RASSF2/RASSF4/YAP1/STK3/TEAD1/MOB1A/TEAD3/PAK1	9
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	14/1765	49/8135	0.1589	0.3006	0.1882	HK3/NAGK/NPL/GNE/UAP1/CYB5R4/UGP2/GNPDA1/HEXB/FPGT/CYB5R2/UGDH/CYB5R3/HEXA	14
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	11/1765	37/8135	0.1608	0.3025	0.1893	PRKCB/PIK3CD/IRS1/ATP1A1/PIK3R1/NR3C2/PIK3R3/MAPK3/MAPK1/NEDD4L/ATP1A2	11
KEGG	hsa04120	Ubiquitin mediated proteolysis	36/1765	142/8135	0.1672	0.3128	0.1958	UBE2L6/CDC20/SOCS3/CBLB/HERC1/UBC/RHOBTB1/DDB2/UBA2/UBE2J1/UBE2Z/FANCL/SIAH1/UBE2C/UBE2A/SMURF2/FBXW7/PIAS1/ANAPC15/BIRC3/UBE2L3/RPS27A/UBE2D3/RNF7/SKP1/PML/CDC23/NEDD4L/WWP1/CUL7/CDC16/UBA3/RHOBTB2/CUL3/UBE2G1/UBOX5	36
KEGG	hsa04213	Longevity regulating pathway - multiple species	17/1765	62/8135	0.1718	0.3197	0.2001	ADCY7/IRS2/PRKACB/FOXO3/CRYAB/FOXO1/PIK3CD/ADCY3/EIF4EBP2/IRS1/PRKAA1/PIK3R1/HDAC1/IGF1R/RPS6KB1/PIK3R3/HSPA2	17
KEGG	hsa05020	Prion disease	66/1765	273/8135	0.1741	0.3221	0.2016	RAC2/NCF1/CYBB/C6/C7/DDIT3/EGR1/CCL5/C1QA/PRKACB/ATF4/MAPK13/NCF4/NCF2/CYBA/NDUFA3/PIK3CD/UQCR11/PSMB2/IL1B/NDUFS3/TUBA1A/C1QB/EIF2S1/COX7A1/LAMC1/PIK3R1/TNF/ITPR3/NDUFA9/KIF5C/CAV2/NDUFB3/TUBA4A/CSNK2A2/UQCRQ/NDUFB5/EIF2AK3/TUBA1B/UQCR10/NOTCH1/PSMD11/NDUFA1/PSMD14/NDUFB11/NDUFB2/HSPA5/PSMD12/PIK3R3/COX5A/PRKCD/TUBA1C/MAPK3/IL6/RAC1/BAX/MAPK1/CASP3/COX7B/HSPA2/PPIF/PSMC4/SLC25A6/C5/ITPR1/FYN	66
KEGG	hsa03040	Spliceosome	37/1765	147/8135	0.1754	0.3227	0.202	EIF4A3/SRSF7/SRSF4/HNRNPA1/CDC5L/SNW1/SNRPA1/BCAS2/WBP11/HNRNPM/TRA2B/SF3B2/PRPF3/SNRPA/TRA2A/SRSF5/HNRNPK/TXNL4A/SF3B3/SF3A1/HNRNPA3/SRSF8/PUF60/NCBP1/HNRNPU/SYF2/LSM4/SRSF3/SF3A3/RBM25/SRSF6/SART1/SRSF10/HSPA2/DHX38/LSM2/PRPF6	37
KEGG	hsa00061	Fatty acid biosynthesis	6/1765	18/8135	0.1777	0.3233	0.2023	ACACB/FASN/ACSL5/HSD17B8/ACACA/MCAT	6
KEGG	hsa00511	Other glycan degradation	6/1765	18/8135	0.1777	0.3233	0.2023	MAN2B1/FUCA1/HEXB/AGA/MANBA/HEXA	6
KEGG	hsa04725	Cholinergic synapse	29/1765	113/8135	0.179	0.3239	0.2027	ADCY7/PRKACB/PRKCB/ATF4/GNG5/FOS/PLCB1/PIK3CD/ADCY3/JAK2/KCNQ1/GNAI2/PLCB3/PIK3CG/PIK3R1/ITPR3/GNG12/GNA11/KCNJ2/GNG10/PIK3R3/BCL2/GNB1/MAPK3/PLCB4/MAPK1/GNG7/ITPR1/FYN	29
KEGG	hsa04930	Type II diabetes mellitus	13/1765	46/8135	0.1812	0.3261	0.2041	SOCS2/HK3/IRS2/SOCS3/ADIPOQ/PIK3CD/IRS1/PIK3R1/TNF/PIK3R3/PRKCD/MAPK3/MAPK1	13
KEGG	hsa00790	Folate biosynthesis	8/1765	26/8135	0.1849	0.331	0.2072	GGH/GPHN/MOCS1/AKR1B10/CBR1/ALPL/AKR1B1/QDPR	8
KEGG	hsa04720	Long-term potentiation	18/1765	67/8135	0.1871	0.3332	0.2085	CALML4/RPS6KA1/PRKACB/PRKCB/ATF4/PPP1CA/PLCB1/PLCB3/RAPGEF3/ITPR3/CREBBP/PPP1CB/RAF1/RAP1B/MAPK3/PLCB4/MAPK1/ITPR1	18
KEGG	hsa04114	Oocyte meiosis	33/1765	131/8135	0.1904	0.3373	0.2111	ADCY7/CALML4/PTTG1/RPS6KA1/PRKACB/CDC20/MAPK13/AR/PPP1CA/SLK/ADCY3/CDK1/CCNB2/CCNB1/ITPR3/PPP1CB/IGF1R/CCNE1/ANAPC15/MAD2L1/PPP2CB/SKP1/MAPK3/CDC23/CDK2/MAPK1/PPP2R5C/PPP2R1B/STAG3/CDC16/YWHAZ/ITPR1/CPEB1	33
KEGG	hsa00270	Cysteine and methionine metabolism	14/1765	51/8135	0.2004	0.3531	0.221	BHMT2/CDO1/CBS/MAT2A/GSS/DNMT1/LDHB/CTH/MPST/AHCYL1/APIP/LDHA/DNMT3B/BCAT2	14
KEGG	hsa04211	Longevity regulating pathway	23/1765	89/8135	0.2025	0.3549	0.2221	ADCY7/IRS2/PRKACB/ATF4/PPARG/ADIPOQ/FOXO3/FOXO1/PIK3CD/ADCY3/RELA/PPARGC1A/IRS1/PRKAA1/PIK3R1/RB1CC1/EIF4E2/IGF1R/RPS6KB1/ADIPOR2/PIK3R3/BAX/ULK1	23
KEGG	hsa00071	Fatty acid degradation	12/1765	43/8135	0.2068	0.3605	0.2256	ADH1B/ADH1C/ADH5/ACSL5/ACADL/ACAT2/ACAT1/ALDH2/GCDH/ECI1/ACAA1/EHHADH	12
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1765	15/8135	0.2105	0.365	0.2285	HEXB/ST8SIA1/ST3GAL2/HEXA/B3GALT4	5
KEGG	hsa00410	beta-Alanine metabolism	9/1765	31/8135	0.2144	0.37	0.2315	AOC3/AOC2/CNDP2/HIBCH/ALDH2/ALDH6A1/GAD1/DPYD/EHHADH	9
KEGG	hsa04613	Neutrophil extracellular trap formation	46/1765	190/8135	0.2211	0.3795	0.2375	RAC2/FCGR3B/NCF1/SYK/CYBB/SELPLG/CLEC7A/PLCG2/CASP1/TLR7/ITGB2/ITGAM/ITGAL/PRKCB/MAPK13/NCF4/ATG7/AQP9/NCF2/CYBA/FCGR2A/PLCB1/PIK3CD/FPR3/RELA/PLCB3/CR1/TLR8/ACTB/PIK3R1/HDAC1/RAF1/FPR1/HDAC3/PIK3R3/CLCN3/MAPK3/RAC1/SIGLEC9/PLCB4/MAPK1/CAMP/PPIF/SLC25A6/C5/C5AR1	46
KEGG	hsa04915	Estrogen signaling pathway	34/1765	138/8135	0.2267	0.3871	0.2423	ADCY7/CALML4/PRKACB/JUN/ATF4/EGFR/HBEGF/GRB2/FOS/HSP90AB1/PLCB1/PIK3CD/ADCY3/GNAI2/PLCB3/HSP90AA1/FKBP5/MMP9/NCOA1/PIK3R1/ITPR3/RAF1/PIK3R3/BCL2/PRKCD/MAPK3/KCNJ5/KRT33A/PLCB4/MAPK1/HSPA2/GPER1/KRT10/ITPR1	34
KEGG	hsa04622	RIG-I-like receptor signaling pathway	18/1765	70/8135	0.2457	0.4153	0.2599	TRAF3/CXCL10/FADD/NFKBIA/MAPK13/CASP8/DDX58/IFIH1/RELA/ISG15/TRADD/TNF/IKBKE/AZI2/IFNA1/RNF125/CHUK/IRF7	18
KEGG	hsa05230	Central carbon metabolism in cancer	18/1765	70/8135	0.2457	0.4153	0.2599	MYC/HK3/IDH2/EGFR/PIK3CD/PTEN/LDHB/PIK3R1/SLC1A5/RAF1/LDHA/PGAM1/FGFR1/SLC2A1/PIK3R3/MET/MAPK3/MAPK1	18
KEGG	hsa05030	Cocaine addiction	13/1765	49/8135	0.252	0.4236	0.2651	FOSB/PRKACB/JUN/ATF4/MAOA/CDK5/SLC6A3/GNAI2/RELA/PDYN/MAOB/GRM3/DRD1	13
KEGG	hsa03018	RNA degradation	20/1765	79/8135	0.254	0.4236	0.2651	BTG2/BTG1/BTG3/HSPD1/DCP2/TOB1/DIS3/HSPA9/TOB2/LSM1/EXOSC2/EXOSC7/DCPS/DCP1A/CNOT8/PARN/CNOT1/LSM4/EXOSC10/LSM2	20
KEGG	hsa00100	Steroid biosynthesis	6/1765	20/8135	0.2544	0.4236	0.2651	LBR/LIPA/DHCR7/DHCR24/FDFT1/CYP2R1	6
KEGG	hsa03022	Basal transcription factors	12/1765	45/8135	0.2579	0.4272	0.2674	TAF7/CCNH/GTF2IRD1/GTF2E1/TAF15/MNAT1/GTF2B/GTF2F1/GTF2E2/TAF4B/GTF2H5/TAF1	12
KEGG	hsa04918	Thyroid hormone synthesis	19/1765	75/8135	0.2603	0.429	0.2685	GPX3/ADCY7/PRKACB/PRKCB/ATF4/PLCB1/GPX7/ADCY3/PLCB3/DUOX2/ATP1A1/PDIA4/ITPR3/ASGR1/HSPA5/PLCB4/PAX8/ATP1A2/ITPR1	19
KEGG	hsa00480	Glutathione metabolism	15/1765	58/8135	0.2641	0.4332	0.2711	GPX3/RRM2/IDH2/LAP3/GSTK1/GPX7/PRDX6/GSS/GGT5/ODC1/GPX4/MGST3/GSTM2/GSTO1/GSTM1	15
KEGG	hsa03015	mRNA surveillance pathway	24/1765	97/8135	0.2668	0.4356	0.2726	PELO/EIF4A3/NXF1/PPP1CA/NXT1/ETF1/UPF3A/SRRM1/RNMT/CPSF7/PNN/PPP1CB/PPP2R2A/NCBP1/PPP2CB/UPF1/GSPT1/SAP18/PPP2R5C/PPP2R1B/PPP2R2D/RNPS1/UPF2/CSTF3	24
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	50/1765	212/8135	0.2738	0.4448	0.2784	BCL6/KLF4/ADCY7/MYC/RPS6KA1/PRKACB/JUN/PRKCB/ATF4/EGFR/VDR/AR/TNFSF11/GRB2/KLF5/FGF2/FOS/ARRB2/HSP90AB1/PIK3CD/VEGFA/ADCY3/JAK2/JAG1/GNAI2/RELA/HSP90AA1/AHR/PIK3R1/ARRB1/IKBKE/CCND1/KPNA2/RB1/FGF4/NOTCH2/RAF1/MGST3/RPS6KB1/PIK3R3/BCL2/MAPK3/MAPK1/GSTM2/GSTO1/CHRNA9/ARNT/KPNA3/GSTM1/CDC6	50
KEGG	hsa04971	Gastric acid secretion	19/1765	76/8135	0.2811	0.4544	0.2844	ADCY7/CALML4/PRKACB/PRKCB/PLCB1/ADCY3/KCNQ1/GNAI2/PLCB3/ACTB/ATP1A1/MYLK/ITPR3/KCNJ2/KCNJ15/CA2/PLCB4/ATP1A2/ITPR1	19
KEGG	hsa00770	Pantothenate and CoA biosynthesis	6/1765	21/8135	0.2957	0.4757	0.2977	ENPP1/PPCDC/ALDH2/PANK2/BCAT2/DPYD	6
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	108/1765	476/8135	0.3115	0.4984	0.3119	GPX3/CYBB/CALML4/UBE2L6/DDIT3/FADD/PRKCB/FZD2/ATF4/MAPK13/PTGS2/WNT11/FZD4/XBP1/FIG4/CDK5/ATP2A3/UBC/HIP1/FRAT2/NDUFA3/FZD1/CASP8/SLC6A3/PLCB1/MAP1LC3B/GPX7/WNT5B/ATXN1/UQCR11/UBE2J1/RELA/PLCB3/RAB8A/PSMB2/DCTN6/PINK1/IL1B/NDUFS3/MAP2K6/TUBA1A/WNT5A/EIF2S1/COX7A1/TNF/ITPR3/NOX4/SPG11/PSEN2/ATG2A/NDUFA9/DERL1/KIF5C/FZD10/NDUFB3/TUBA4A/CSNK2A2/UQCRQ/TNFRSF1B/VAPB/RB1CC1/PDYN/SQSTM1/NDUFB5/PPID/BID/RAF1/EIF2AK3/TUBA1B/UQCR10/UBE2L3/PSMD11/NDUFA1/RPS27A/PSMD14/PSEN1/NDUFB11/NDUFB2/HSPA5/PSMD12/FAS/WNT16/BCL2/COX5A/TUBA1C/MAPK3/IL6/RAC1/BAX/BAK1/PLCB4/MAPK1/UCHL1/CASP3/STX1A/DNAL4/COX7B/FASLG/CSF1/PPIF/UBE2G1/PSMC4/SLC25A6/TOMM40/LRP6/DCTN5/ULK1/ITPR1	108
KEGG	hsa04973	Carbohydrate digestion and absorption	12/1765	47/8135	0.3128	0.4984	0.3119	HK3/PRKCB/PLCB1/PIK3CD/SLC37A4/PLCB3/ATP1A1/PIK3R1/PIK3R3/PLCB4/GNAT3/ATP1A2	12
KEGG	hsa04146	Peroxisome	20/1765	82/8135	0.3158	0.5005	0.3132	PEX5/IDH2/GSTK1/AGPS/ACSL5/GNPAT/PEX19/PAOX/PEX26/PEX7/PEX2/PEX11B/PXMP2/ABCD3/PXMP4/CRAT/ACAA1/PHYH/EHHADH/PEX16	20
KEGG	hsa05031	Amphetamine addiction	17/1765	69/8135	0.3192	0.5005	0.3132	FOSB/CALML4/PRKACB/JUN/PRKCB/ATF4/MAOA/FOS/PPP1CA/SLC6A3/HDAC1/PPP1CB/ARC/PDYN/MAOB/STX1A/DRD1	17
KEGG	hsa05032	Morphine addiction	22/1765	91/8135	0.32	0.5005	0.3132	ADCY7/PRKACB/PRKCB/GNG5/ARRB2/PDE4B/ADCY3/GNAI2/GRK6/PDE2A/GRK5/ARRB1/GNG12/PDE1A/GNG10/GABRA2/GNB1/KCNJ5/PDE8B/PDE8A/DRD1/GNG7	22
KEGG	hsa05014	Amyotrophic lateral sclerosis	83/1765	364/8135	0.3201	0.5005	0.3132	GPX3/DDIT3/CASP1/SRSF7/ATF4/MAPK13/XBP1/FIG4/NXF1/NUP62/NUP210/HNRNPA1/NDUFA3/NXT1/MAP1LC3B/GPX7/UQCR11/NUP153/RAB8A/PSMB2/DCTN6/PINK1/NUP37/POM121C/NDUFS3/ACTB/MAP2K6/TUBA1A/EIF2S1/COX7A1/PFN1/NUP43/TNF/ITPR3/SPG11/ATG2A/NDUFA9/DERL1/KIF5C/NDUFB3/TUBA4A/UQCRQ/TNFRSF1B/VAPB/RB1CC1/ANG/NUP50/SQSTM1/HNRNPA3/NDUFB5/BID/EIF2AK3/TUBA1B/NCBP1/UQCR10/SEC13/PSMD11/NDUFA1/RANBP2/PSMD14/NRG2/SRSF3/NDUFB11/NDUFB2/HSPA5/PSMD12/SETX/BCL2/COX5A/TUBA1C/RAC1/BAX/NUP155/NUP54/CASP3/DNAL4/COX7B/PFN2/PSMC4/TOMM40/UBQLN2/DCTN5/ULK1	83
KEGG	hsa00513	Various types of N-glycan biosynthesis	10/1765	39/8135	0.332	0.5167	0.3234	RPN2/MAN2A1/MGAT4A/HEXB/MAN1A1/DDOST/MGAT1/MGAT4B/MGAT2/HEXA	10
KEGG	hsa00590	Arachidonic acid metabolism	15/1765	61/8135	0.3378	0.5213	0.3263	GPX3/ALOX5/PTGS2/PLA2G2D/CBR1/GPX7/PLA2G4C/GGT5/PTGDS/CBR3/TBXAS1/LTC4S/PTGS1/PLA2G2F/PLA2G2A	15
KEGG	hsa00340	Histidine metabolism	6/1765	22/8135	0.3381	0.5213	0.3263	MAOA/HNMT/CNDP2/ALDH2/AOC1/MAOB	6
KEGG	hsa05010	Alzheimer disease	87/1765	384/8135	0.3398	0.5214	0.3263	CYBB/CALML4/DDIT3/FADD/IRS2/FZD2/ATF4/PTGS2/WNT11/FZD4/XBP1/LPL/CDK5/ATP2A3/SLC39A14/FRAT2/NDUFA3/FZD1/CASP8/PLCB1/SLC39A8/PIK3CD/WNT5B/UQCR11/RELA/PLCB3/PSMB2/IL1B/IRS1/NDUFS3/TUBA1A/WNT5A/EIF2S1/COX7A1/PIK3R1/TNF/ITPR3/NOX4/PSEN2/ATG2A/NDUFA9/KIF5C/FZD10/NDUFB3/TUBA4A/CSNK2A2/UQCRQ/RB1CC1/RTN4/NDUFB5/PPID/BID/RAF1/APH1B/LRP1/EIF2AK3/TUBA1B/UQCR10/EIF2AK2/APBB1/PSMD11/NDUFA1/PSMD14/PSEN1/NDUFB11/NDUFB2/PSMD12/FAS/WNT16/NCSTN/PIK3R3/COX5A/TUBA1C/MAPK3/IL6/PLCB4/MAPK1/CHUK/CASP3/COX7B/CSF1/PPIF/PSMC4/SLC25A6/LRP6/ULK1/ITPR1	87
KEGG	hsa04917	Prolactin signaling pathway	17/1765	70/8135	0.3427	0.5235	0.3277	SOCS2/SOCS3/MAPK13/FOXO3/TNFSF11/GRB2/STAT1/FOS/PIK3CD/JAK2/RELA/PIK3R1/CCND1/RAF1/PIK3R3/MAPK3/MAPK1	17
KEGG	hsa04726	Serotonergic synapse	27/1765	115/8135	0.3553	0.5402	0.3381	PRKACB/PRKCB/ALOX5/MAOA/PTGS2/DUSP1/GNG5/PLCB1/PLA2G4C/GNAI2/PLCB3/RAPGEF3/ITPR3/GNG12/RAF1/GNG10/PTGS1/MAOB/GNB1/TRPC1/MAPK3/KCNJ5/PLCB4/MAPK1/CASP3/GNG7/ITPR1	27
KEGG	hsa00260	Glycine, serine and threonine metabolism	10/1765	40/8135	0.364	0.5509	0.3448	AOC3/MAOA/CBS/AOC2/CTH/GATM/SHMT2/PGAM1/MAOB/GCAT	10
KEGG	hsa04966	Collecting duct acid secretion	7/1765	27/8135	0.367	0.553	0.3461	ATP6V0E2/ATP6V1A/SLC12A7/TCIRG1/ATP6V1D/ATP6V0D1/CA2	7
KEGG	hsa00564	Glycerophospholipid metabolism	23/1765	98/8135	0.3724	0.5586	0.3496	PLA2G2D/AGPAT4/CHPT1/PLA2G4C/GPD1/LPGAT1/CHKA/DGKZ/LYPLA1/GNPAT/PTDSS1/GPD1L/PLA2G15/LPIN1/PNPLA6/PEMT/ETNK1/PLA2G2F/CEPT1/DGKA/MBOAT2/LPCAT3/PLA2G2A	23
KEGG	hsa03030	DNA replication	9/1765	36/8135	0.3768	0.5626	0.3521	MCM5/MCM2/FEN1/RFC4/RPA3/PCNA/POLD2/RNASEH2A/LIG1	9
KEGG	hsa03060	Protein export	6/1765	23/8135	0.3811	0.5664	0.3545	SPCS1/SPCS3/SEC61B/SPCS2/SEC63/HSPA5	6
KEGG	hsa02010	ABC transporters	11/1765	45/8135	0.3827	0.5664	0.3545	ABCA5/ABCC4/TAP1/ABCA8/ABCG1/ABCC10/ABCC3/ABCD3/ABCB7/ABCA7/ABCC5	11
KEGG	hsa04623	Cytosolic DNA-sensing pathway	15/1765	63/8135	0.3892	0.5734	0.3589	CASP1/CCL5/CXCL10/NFKBIA/PYCARD/AIM2/DDX58/RELA/IL1B/IKBKE/ADAR/IFNA1/IL6/CHUK/IRF7	15
KEGG	hsa00510	N-Glycan biosynthesis	12/1765	50/8135	0.3995	0.5861	0.3668	RPN2/MAN2A1/MGAT5/ST6GAL1/MGAT4A/MAN1A1/ALG6/DPAGT1/DDOST/MGAT1/MGAT4B/MGAT2	12
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1765	77/8135	0.4033	0.589	0.3687	TCF7L2/TCF7L1/LAMA2/ATP2A3/ITGA4/LEF1/DSC2/SGCA/ITGA10/ITGA5/SLC8A1/CACNB2/ACTB/SGCD/ITGB7/ITGA7/EMD/TCF7	18
KEGG	hsa03410	Base excision repair	8/1765	33/8135	0.4274	0.6215	0.389	PARP1/PARP4/FEN1/PCNA/POLD2/POLB/APEX2/LIG1	8
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1765	11/8135	0.4388	0.6353	0.3977	VKORC1/NQO1/COQ2	3
KEGG	hsa04713	Circadian entrainment	22/1765	97/8135	0.4462	0.6433	0.4026	ADCY7/CALML4/PER3/PRKACB/PRKCB/GNG5/FOS/PLCB1/ADCY3/GNAI2/PLCB3/ITPR3/GNG12/PER2/GNG10/GNB1/MAPK3/KCNJ5/PLCB4/MAPK1/GNG7/ITPR1	22
KEGG	hsa04970	Salivary secretion	21/1765	93/8135	0.4583	0.6578	0.4117	ADCY7/CALML4/PRKACB/PRKCB/CD38/LYZ/PLCB1/KCNN4/ADCY3/PLCB3/ATP1A1/ITPR3/SLC12A2/CST2/PLCB4/ATP2B4/BST1/CAMP/CST4/ATP1A2/ITPR1	21
KEGG	hsa04922	Glucagon signaling pathway	24/1765	107/8135	0.4646	0.664	0.4156	CALML4/PRKACB/ATF4/FOXO1/ACACB/FBP1/SIK1/PCK1/PLCB1/PLCB3/PPARGC1A/LDHB/PRKAA1/ITPR3/CREBBP/LDHA/PGAM1/PHKA1/SLC2A1/PLCB4/ACACA/ITPR1/PHKB/GYS2	24
KEGG	hsa04020	Calcium signaling pathway	53/1765	240/8135	0.4672	0.6649	0.4162	ADCY7/EDNRB/CALML4/PLCG2/AGTR1/PRKACB/PRKCB/CD38/PTAFR/EGFR/ITPKC/NTRK2/P2RX7/P2RX5/GNA15/FGF2/ATP2A3/PLCB1/ITPKB/VEGFA/ADCY3/PLCB3/ORAI2/SLC8A1/VEGFC/PLN/CXCR4/MYLK/PDGFD/ITPR3/ASPH/BDKRB2/P2RX4/GNA11/FGF4/PDE1A/PDGFC/F2R/TACR1/PHKA1/FGF23/FGFR1/MET/PLCB4/PTK2B/ATP2B4/BDKRB1/PPIF/SLC25A6/GNAL/DRD1/ITPR1/PHKB	53
KEGG	hsa00360	Phenylalanine metabolism	4/1765	16/8135	0.4695	0.6653	0.4164	AOC3/MAOA/AOC2/MAOB	4
KEGG	hsa04974	Protein digestion and absorption	23/1765	103/8135	0.4765	0.6724	0.4208	COL3A1/COL1A2/COL5A2/SLC7A7/COL5A1/COL1A1/SLC3A2/SLC36A1/KCNN4/KCNQ1/SLC8A1/CPB1/COL13A1/ATP1A1/COL4A6/SLC1A1/SLC1A5/SLC38A2/SLC7A8/COL4A5/DPP4/ATP1A2/KCNK5	23
KEGG	hsa00240	Pyrimidine metabolism	13/1765	58/8135	0.4987	0.7007	0.4386	RRM2/TYMS/ENTPD1/DCK/ENPP1/TK1/DTYMK/ASMTL/NME6/CDA/HDDC2/DPYD/TYMP	13
KEGG	hsa04911	Insulin secretion	19/1765	86/8135	0.5069	0.7092	0.4439	ADCY7/PRKACB/PRKCB/ATF4/PLCB1/KCNN4/ADCY3/PLCB3/ATP1A1/ITPR3/KCNMB1/GNA11/KCNN3/SLC2A1/PLCB4/STX1A/TRPM4/GLP1R/ATP1A2	19
KEGG	hsa00310	Lysine degradation	14/1765	63/8135	0.5091	0.7094	0.444	AASS/SMYD2/ACAT2/EZH2/EZH1/ACAT1/ALDH2/GCDH/SETMAR/MECOM/SETD1A/COLGALT1/EHHADH/COLGALT2	14
KEGG	hsa04979	Cholesterol metabolism	11/1765	50/8135	0.5348	0.7412	0.4639	LPL/NPC2/LIPA/APOB/LDLR/NPC1/VAPB/LRP1/ANGPTL4/PLTP/MYLIP	11
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/1765	22/8135	0.5364	0.7412	0.4639	ACAT2/HMGCS1/ACAT1/IDI1/ICMT	5
KEGG	hsa00330	Arginine and proline metabolism	11/1765	51/8135	0.564	0.7761	0.4857	MAOA/LAP3/AGMAT/ODC1/CNDP2/GATM/ALDH2/ARG2/AOC1/MAOB/CKB	11
KEGG	hsa03430	Mismatch repair	5/1765	23/8135	0.5796	0.7897	0.4943	RFC4/RPA3/PCNA/POLD2/LIG1	5
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	5/1765	23/8135	0.5796	0.7897	0.4943	PCK1/ATP1A1/CA2/CA4/ATP1A2	5
KEGG	hsa05168	Herpes simplex virus 1 infection	106/1765	495/8135	0.581	0.7897	0.4943	HLA-DMB/HLA-DPB1/SYK/HLA-DMA/TRAF3/HLA-DPA1/CD74/HLA-DRA/CCL5/HLA-DOB/PILRA/FADD/SRSF7/OAS2/NFKBIA/SOCS3/MYD88/OAS1/ZNF184/TAP1/ZNF331/IFNAR2/TAPBP/NXF1/IRF9/STAT1/HLA-DOA/SRSF4/PPP1CA/CASP8/CFP/OAS3/DDX58/PIK3CD/ZNF544/ZNF669/IFIH1/JAK2/RELA/ZNF557/ITGA5/HLA-F/PDIA3/IL1B/TRADD/EIF2S1/B2M/HLA-G/TICAM1/PIK3R1/TNF/ZNF107/ZNF34/TLR3/HLA-B/SRSF5/ZNF671/IKBKE/ZFP37/ZNF529/PPP1CB/ZNF91/ZNF200/HLA-C/IFNGR2/TRAF5/ZNF267/SRSF8/BID/HLA-A/HLA-DQA1/EIF2AK3/BIRC3/EIF2AK2/ZNF337/IRAK4/SRSF3/ZNF430/ZNF254/ZNF212/SRSF6/FAS/PIK3R3/IFNA1/BCL2/PML/IL6/BAX/BAK1/ZNF136/HLA-DRB4/ZNF155/CHUK/CASP3/ZNF12/HLA-DQB1/ZNF3/FASLG/IRF7/POU2F1/IRAK1/ZNF571/C5/TNFRSF14/ZNF614/ZNF665	106
KEGG	hsa03420	Nucleotide excision repair	10/1765	47/8135	0.5852	0.7922	0.4958	CCNH/DDB2/RFC4/RPA3/MNAT1/PCNA/POLD2/XPC/GTF2H5/LIG1	10
KEGG	hsa04024	cAMP signaling pathway	47/1765	221/8135	0.5893	0.7944	0.4972	RAC2/ADCY7/CALML4/PRKACB/JUN/VAV1/NFKBIA/SOX9/ABCC4/FOS/ATP2A3/PPP1CA/PDE4B/NPY1R/PIK3CD/ADCY3/GNAI2/RELA/PLN/LIPE/ATP1A1/PIK3R1/RAPGEF3/FXYD1/VAV3/CREBBP/PPP1CB/NPR1/RRAS2/RAF1/F2R/RAP1B/FFAR2/MYL9/ROCK2/PIK3R3/MAPK3/RAC1/RHOA/MAPK1/ATP2B4/PPP1R12A/VIPR2/PAK1/GLP1R/ATP1A2/DRD1	47
KEGG	hsa04130	SNARE interactions in vesicular transport	7/1765	33/8135	0.5951	0.7991	0.5002	YKT6/VAMP5/VAMP8/BET1/STX1A/STX7/GOSR2	7
KEGG	hsa01212	Fatty acid metabolism	12/1765	57/8135	0.5991	0.8012	0.5014	FASN/ACSL5/HSD17B8/SCD/PPT1/ACADL/ACAT2/ACAT1/ACACA/ACAA1/MCAT/EHHADH	12
KEGG	hsa04977	Vitamin digestion and absorption	5/1765	24/8135	0.6205	0.8248	0.5162	SLC19A2/SLC19A3/APOB/SLC5A6/TCN2	5
KEGG	hsa05414	Dilated cardiomyopathy	20/1765	96/8135	0.6217	0.8248	0.5162	ADCY7/PRKACB/LAMA2/ATP2A3/ITGA4/SGCA/TGFB2/ADCY3/ITGA10/ITGA5/SLC8A1/CACNB2/PLN/ACTB/TNF/SGCD/ITGB7/ITGA7/TGFB3/EMD	20
KEGG	hsa00040	Pentose and glucuronate interconversions	7/1765	34/8135	0.6292	0.8289	0.5188	AKR1A1/AKR1B10/UGP2/DCXR/AKR1B1/UGDH/GUSB	7
KEGG	hsa03010	Ribosome	33/1765	158/8135	0.6297	0.8289	0.5188	RPS28/RPS23/MRPL35/RPLP0/RPL23A/RPL3/RPL30/RPS12/RPL11/MRPL15/RPL39/RPL29/RPL7/RPS17/RPL24/RPL19/RPS4Y1/RPL31/RPS27A/RPS15/RPL12/RPL14/RPL41/RPL32/RPS5/RPL18/RPL9/RPL34/MRPS18A/RPS27/MRPS2/RSL24D1/RPS27L	33
KEGG	hsa04962	Vasopressin-regulated water reabsorption	9/1765	44/8135	0.638	0.8364	0.5235	ARHGDIB/PRKACB/DYNC1I1/ADCY3/DYNLL1/DCTN6/DYNC1LI2/DYNC2H1/DCTN5	9
KEGG	hsa04721	Synaptic vesicle cycle	16/1765	78/8135	0.6445	0.8416	0.5268	STXBP1/CLTC/ATP6V0E2/ATP6V1A/SLC6A3/ATP6V0B/TCIRG1/CLTCL1/SLC1A1/ATP6V1D/ATP6V0D1/SLC6A12/AP2A2/STX1A/CLTA/AP2S1	16
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	31/1765	150/8135	0.653	0.8479	0.5307	ADCY7/CALML4/AGTR1/PRKACB/ATF4/MAPK13/ATP2A3/PPP1CA/PLCB1/ADCY3/KCNQ1/GNAI2/PLCB3/SLC8A1/CACNB2/PLN/PIK3CG/ATP1A1/RAPGEF3/PPP1CB/PPP2R2A/PPP2CB/BCL2/MAPK3/PLCB4/MAPK1/PPP2R5C/ATP2B4/PPP2R1B/PPP2R2D/ATP1A2	31
KEGG	hsa00592	alpha-Linolenic acid metabolism	5/1765	25/8135	0.6589	0.8479	0.5307	PLA2G2D/PLA2G4C/PLA2G2F/ACAA1/PLA2G2A	5
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1765	20/8135	0.6595	0.8479	0.5307	CHST7/UST/CHST11/CHPF2	4
KEGG	hsa00670	One carbon pool by folate	4/1765	20/8135	0.6595	0.8479	0.5307	TYMS/MTHFD2/MTHFD2L/SHMT2	4
KEGG	hsa05012	Parkinson disease	55/1765	266/8135	0.6828	0.86	0.5382	CALML4/UBE2L6/DDIT3/PRKACB/ATF4/MAOA/DUSP1/XBP1/UBC/SLC39A14/NDUFA3/SLC6A3/SLC39A8/UQCR11/UBE2J1/GNAI2/PSMB2/PINK1/NDUFS3/TUBA1A/EIF2S1/COX7A1/ITPR3/NDUFA9/KIF5C/NDUFB3/TUBA4A/UQCRQ/NDUFB5/EIF2AK3/TUBA1B/UQCR10/UBE2L3/PSMD11/NDUFA1/RPS27A/PSMD14/NDUFB11/NDUFB2/HSPA5/PSMD12/MAOB/COX5A/TUBA1C/BAX/UCHL1/CASP3/COX7B/PPIF/UBE2G1/PSMC4/SLC25A6/GNAL/DRD1/ITPR1	55
KEGG	hsa04724	Glutamatergic synapse	23/1765	114/8135	0.6898	0.86	0.5382	ADCY7/PRKACB/PRKCB/GNG5/PLCB1/PLA2G4C/ADCY3/GNAI2/PLCB3/ITPR3/GNG12/SLC1A1/SLC38A2/GRM6/GNG10/GNB1/TRPC1/MAPK3/PLCB4/MAPK1/GRM3/GNG7/ITPR1	23
KEGG	hsa00500	Starch and sucrose metabolism	7/1765	36/8135	0.6921	0.86	0.5382	HK3/GBE1/ENPP1/UGP2/AGL/GAA/GYS2	7
KEGG	hsa00512	Mucin type O-glycan biosynthesis	7/1765	36/8135	0.6921	0.86	0.5382	GALNT1/GALNT6/GCNT1/GALNT7/ST3GAL2/GALNT10/C1GALT1C1	7
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	7/1765	36/8135	0.6921	0.86	0.5382	CD38/AOX1/ENPP1/NAMPT/NMRK1/SIRT7/BST1	7
KEGG	hsa03440	Homologous recombination	8/1765	41/8135	0.6925	0.86	0.5382	UIMC1/ATM/NBN/RPA3/TOPBP1/POLD2/BARD1/TOP3A	8
KEGG	hsa05017	Spinocerebellar ataxia	29/1765	143/8135	0.6925	0.86	0.5382	PRKCB/XBP1/RORA/PUM1/ATP2A3/PLCB1/PIK3CD/KAT5/ATXN1/PLCB3/PSMB2/PIK3R1/ITPR3/ATG2A/RB1CC1/GTF2B/PDYN/VLDLR/PSMD11/PSMD14/PSMD12/PIK3R3/PLCB4/AFG3L2/PPIF/PSMC4/SLC25A6/ULK1/ITPR1	29
KEGG	hsa05410	Hypertrophic cardiomyopathy	18/1765	90/8135	0.6926	0.86	0.5382	LAMA2/ATP2A3/ITGA4/SGCA/TGFB2/ITGA10/ITGA5/SLC8A1/CACNB2/ACTB/PRKAA1/TNF/SGCD/ITGB7/ITGA7/TGFB3/EMD/IL6	18
KEGG	hsa03050	Proteasome	9/1765	46/8135	0.6934	0.86	0.5382	PSMB9/PSMB8/PSMB10/PSME1/PSMB2/PSMD11/PSMD14/PSMD12/PSMC4	9
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1765	26/8135	0.6947	0.86	0.5382	PIGA/PIGZ/PIGF/PIGV/PIGL	5
KEGG	hsa01240	Biosynthesis of cofactors	31/1765	153/8135	0.6987	0.8617	0.5393	GGH/MTHFD2/AKR1A1/KMO/GPHN/MOCS1/KYNU/VKORC1/TDO2/ALPL/MAT2A/NQO1/UROS/PDXK/GSS/IDO1/UGP2/COQ2/RFK/NME6/PPCDC/TPK1/MTHFD2L/ALDH2/SHMT2/UGDH/DHRS3/PANK2/BCAT2/ALAD/GUSB	31
KEGG	hsa00514	Other types of O-glycan biosynthesis	9/1765	47/8135	0.719	0.8803	0.551	GALNT1/GALNT6/ST6GAL1/GALNT7/MFNG/COLGALT1/GALNT10/C1GALT1C1/COLGALT2	9
KEGG	hsa01250	Biosynthesis of nucleotide sugars	7/1765	37/8135	0.7209	0.8803	0.551	HK3/NAGK/GNE/UAP1/UGP2/FPGT/UGDH	7
KEGG	hsa00010	Glycolysis / Gluconeogenesis	13/1765	67/8135	0.7217	0.8803	0.551	ADH1B/HK3/ADH1C/AKR1A1/FBP1/PCK1/ADH5/LDHB/MINPP1/ALDH2/LDHA/PGAM1/ADPGK	13
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1765	27/8135	0.7278	0.8846	0.5536	ST3GAL6/B3GALNT1/FUT4/A4GALT/ST8SIA1	5
KEGG	hsa00450	Selenocompound metabolism	3/1765	17/8135	0.7476	0.902	0.5646	PAPSS1/CTH/PAPSS2	3
KEGG	hsa00910	Nitrogen metabolism	3/1765	17/8135	0.7476	0.902	0.5646	CA2/CA4/CA12	3
KEGG	hsa00051	Fructose and mannose metabolism	6/1765	33/8135	0.7519	0.904	0.5658	HK3/AKR1B10/FBP1/PFKFB3/AKR1B1/FPGT	6
KEGG	hsa00230	Purine metabolism	25/1765	128/8135	0.7571	0.9044	0.5661	ADCY7/RRM2/ENTPD1/PAPSS1/IMPDH2/DCK/IMPDH1/AMPD3/ENPP4/PDE4B/NPR2/ENPP1/ADCY3/PDE6D/PDE2A/NME6/PDE9A/NPR1/PDE1A/HDDC2/PAPSS2/GMPR/PDE8B/PAICS/PDE8A	25
KEGG	hsa04924	Renin secretion	13/1765	69/8135	0.7615	0.9044	0.5661	CALML4/CTSB/AGTR1/PRKACB/PLCB1/GNAI2/PLCB3/ITPR3/NPR1/KCNJ2/PDE1A/PLCB4/ITPR1	13
KEGG	hsa04727	GABAergic synapse	17/1765	89/8135	0.7627	0.9044	0.5661	ADCY7/GABARAPL1/PRKACB/PRKCB/GPHN/GNG5/ADCY3/GNAI2/TRAK2/GNG12/SLC38A2/GAD1/SLC6A12/GNG10/GABRA2/GNB1/GNG7	17
KEGG	hsa04723	Retrograde endocannabinoid signaling	29/1765	148/8135	0.7636	0.9044	0.5661	ADCY7/PRKACB/PRKCB/MAPK13/PTGS2/GNG5/NDUFA3/PLCB1/ADCY3/GNAI2/PLCB3/NDUFS3/ITPR3/NDUFA9/NDUFB3/GNG12/NDUFB5/NDUFA1/NDUFB11/NDUFB2/GNG10/GABRA2/GNB1/MAPK3/KCNJ5/PLCB4/MAPK1/GNG7/ITPR1	29
KEGG	hsa00565	Ether lipid metabolism	9/1765	49/8135	0.7659	0.9044	0.5661	PLA2G2D/AGPS/CHPT1/PLA2G4C/PAFAH1B3/PLA2G7/PLA2G2F/CEPT1/PLA2G2A	9
KEGG	hsa01232	Nucleotide metabolism	16/1765	85/8135	0.7789	0.9165	0.5736	RRM2/TYMS/ENTPD1/IMPDH2/DCK/IMPDH1/AMPD3/ENPP1/TK1/DTYMK/ASMTL/NME6/CDA/HDDC2/GMPR/TYMP	16
KEGG	hsa00561	Glycerolipid metabolism	11/1765	61/8135	0.8009	0.9383	0.5873	AKR1A1/AKR1B10/LPL/PNPLA2/AGPAT4/DGKZ/AKR1B1/ALDH2/LPIN1/DGKA/MBOAT2	11
KEGG	hsa04340	Hedgehog signaling pathway	10/1765	56/8135	0.8035	0.9383	0.5873	PRKACB/ARRB2/ARRB1/GAS1/CCND1/GPR161/SMURF2/BCL2/CUL3/EVC	10
KEGG	hsa04913	Ovarian steroidogenesis	9/1765	51/8135	0.807	0.9383	0.5873	ADCY7/PRKACB/ALOX5/PTGS2/PLA2G4C/ADCY3/LDLR/IGF1R/CYP11A1	9
KEGG	hsa03450	Non-homologous end-joining	2/1765	13/8135	0.8088	0.9383	0.5873	FEN1/POLM	2
KEGG	hsa00982	Drug metabolism - cytochrome P450	13/1765	72/8135	0.8137	0.9383	0.5873	ADH1B/ADH1C/FMO2/MAOA/AOX1/GSTK1/ADH5/FMO1/MGST3/MAOB/GSTM2/GSTO1/GSTM1	13
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	3/1765	19/8135	0.8143	0.9383	0.5873	IDH2/IDH3B/BCAT2	3
KEGG	hsa00600	Sphingolipid metabolism	9/1765	52/8135	0.8253	0.9464	0.5924	SGPL1/ARSA/CERK/HEXB/KDSR/SGMS1/HEXA/CERS2/GALC	9
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/1765	78/8135	0.8271	0.9464	0.5924	ADH1B/ADH1C/GSTK1/AKR1C1/CBR1/ADH5/HSD11B1/CBR3/AKR7A2/MGST3/CYP2F1/GSTM2/GSTO1/GSTM1	14
KEGG	hsa00052	Galactose metabolism	5/1765	31/8135	0.8342	0.9513	0.5954	HK3/AKR1B10/UGP2/AKR1B1/GAA	5
KEGG	hsa05322	Systemic lupus erythematosus	25/1765	136/8135	0.8539	0.962	0.6021	FCGR3B/HLA-DMB/HLA-DPB1/HLA-DMA/HLA-DPA1/C6/HLA-DRA/C7/CD28/HLA-DOB/C1QA/TRIM21/C2/HLA-DOA/CD86/FCGR2A/CD40/C1QB/TNF/CD40LG/HLA-DQA1/C1R/HLA-DRB4/HLA-DQB1/C5	25
KEGG	hsa00983	Drug metabolism - other enzymes	14/1765	80/8135	0.8544	0.962	0.6021	RRM2/IMPDH2/IMPDH1/NAT1/TK1/NME6/CDA/MGST3/GSTM2/GSTO1/DPYD/TYMP/GSTM1/GUSB	14
KEGG	hsa04136	Autophagy - other	5/1765	32/8135	0.8547	0.962	0.6021	GABARAPL1/ATG7/ATG2A/ATG4A/PPP2CB	5
KEGG	hsa01230	Biosynthesis of amino acids	13/1765	75/8135	0.8569	0.962	0.6021	IDH2/ASS1/CBS/MAT2A/CTH/PC/ARG2/IDH3B/SHMT2/ASNS/PGAM1/TALDO1/BCAT2	13
KEGG	hsa03460	Fanconi anemia pathway	9/1765	54/8135	0.858	0.962	0.6021	HES1/REV3L/RMI1/FANCG/RPA3/FANCL/FANCE/TOP3A/POLI	9
KEGG	hsa00730	Thiamine metabolism	2/1765	15/8135	0.8687	0.9707	0.6076	ALPL/TPK1	2
KEGG	hsa00591	Linoleic acid metabolism	4/1765	29/8135	0.9024	1	0.6259	PLA2G2D/PLA2G4C/PLA2G2F/PLA2G2A	4
KEGG	hsa04614	Renin-angiotensin system	3/1765	23/8135	0.9037	1	0.6259	AGTR1/ATP6AP2/ENPEP	3
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	11/1765	69/8135	0.9092	1	0.6259	PTGS2/GSTK1/SULT1A1/NAT1/CBR1/SULT1A2/HSD11B1/MGST3/GSTM2/GSTO1/GSTM1	11
KEGG	hsa00020	Citrate cycle (TCA cycle)	4/1765	30/8135	0.9164	1	0.6259	IDH2/PCK1/PC/IDH3B	4
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/1765	30/8135	0.9164	1	0.6259	AKR1A1/ALDH2/UGDH/GUSB	4
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1765	30/8135	0.9164	1	0.6259	ACAT2/ACAT1/PCCB/SHMT2	4
KEGG	hsa04975	Fat digestion and absorption	6/1765	43/8135	0.9289	1	0.6259	PLA2G2D/APOB/ACAT2/ACAT1/PLA2G2F/PLA2G2A	6
KEGG	hsa05206	MicroRNAs in cancer	57/1765	310/8135	0.9369	1	0.6259	CDKN1A/SPRY2/MARCKS/MYC/PLCG2/EFNA5/IRS2/PRKCB/EGFR/ZFPM2/PTGS2/PIM1/ATM/GRB2/BCL2L2/DDIT4/STMN1/TGFB2/PIK3CD/VEGFA/PTEN/MAPK7/ABL1/ITGA5/DNMT1/IRS1/DICER1/MMP9/RECK/PIK3R1/BCL2L11/EZH2/FSCN1/HDAC1/HNRNPK/CREBBP/CCND1/NOTCH2/CCNE1/RAF1/ZEB2/NOTCH1/SLC7A1/THBS1/TIMP3/BMPR2/PIK3R3/MET/BCL2/CDC25B/DNMT3B/MAPK3/BAK1/RHOA/MAPK1/CASP3/CDKN1B	57
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/1765	27/8135	0.9522	1	0.6259	ACOT7/SCD/ACAA1	3
KEGG	hsa04260	Cardiac muscle contraction	13/1765	87/8135	0.9574	1	0.6259	ATP2A3/UQCR11/SLC8A1/CACNB2/COX7A1/ATP1A1/ASPH/UQCRQ/UQCR10/COX5A/COX7B/SLC9A6/ATP1A2	13
KEGG	hsa01200	Carbon metabolism	18/1765	115/8135	0.9595	1	0.6259	HK3/IDH2/FBP1/ME2/ADH5/ACAT2/PC/ME1/ACAT1/HIBCH/IDH3B/ALDH6A1/PCCB/SHMT2/PGAM1/ESD/TALDO1/ADPGK	18
KEGG	hsa00220	Arginine biosynthesis	2/1765	22/8135	0.9675	1	0.6259	ASS1/ARG2	2
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1765	14/8135	0.9675	1	0.6259	ST3GAL2	1
KEGG	hsa05016	Huntington disease	54/1765	306/8135	0.9682	1	0.6259	GPX3/PPARG/CLTC/HIP1/NDUFA3/CASP8/PLCB1/GPX7/TFAM/UQCR11/PLCB3/PPARGC1A/PSMB2/DCTN6/NDUFS3/TUBA1A/COX7A1/ATG2A/NDUFA9/KIF5C/HDAC1/CLTCL1/NDUFB3/TUBA4A/UQCRQ/CREBBP/RB1CC1/NDUFB5/TUBA1B/UQCR10/PSMD11/NDUFA1/PSMD14/NDUFB11/NDUFB2/AP2A2/TAF4B/PSMD12/COX5A/TUBA1C/BAX/PLCB4/CASP3/STX1A/DNAL4/CLTA/COX7B/PPIF/PSMC4/SLC25A6/DCTN5/AP2S1/ULK1/ITPR1	54
KEGG	hsa00860	Porphyrin metabolism	5/1765	43/8135	0.9713	1	0.6259	CP/UROS/BLVRA/ALAD/GUSB	5
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	4/1765	37/8135	0.9735	1	0.6259	ASS1/ASNS/GAD1/ALDH5A1	4
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1765	24/8135	0.9785	1	0.6259	HS3ST2/EXT1	2
KEGG	hsa00190	Oxidative phosphorylation	20/1765	134/8135	0.982	1	0.6259	ATP6V0E2/NDUFA3/ATP6V1A/UQCR11/NDUFS3/ATP6V0B/COX7A1/NDUFA9/TCIRG1/NDUFB3/UQCRQ/NDUFB5/ATP6V1D/UQCR10/NDUFA1/ATP6V0D1/NDUFB11/NDUFB2/COX5A/COX7B	20
KEGG	hsa04976	Bile secretion	12/1765	89/8135	0.9827	1	0.6259	ADCY7/PRKACB/ABCC4/AQP9/ADCY3/ABCC3/LDLR/ATP1A1/CA2/SLC2A1/SCT/ATP1A2	12
KEGG	hsa04950	Maturity onset diabetes of the young	2/1765	26/8135	0.9859	1	0.6259	HES1/HHEX	2
KEGG	hsa04742	Taste transduction	11/1765	86/8135	0.9881	1	0.6259	PRKACB/PLCB1/PLCB3/ITPR3/SCN3A/PDE1A/GABRA2/PLCB4/GNAT3/KCNK5/SCN9A	11
KEGG	hsa00062	Fatty acid elongation	2/1765	27/8135	0.9886	1	0.6259	ACOT7/PPT1	2
KEGG	hsa04714	Thermogenesis	37/1765	232/8135	0.9894	1	0.6259	ADCY7/RPS6KA1/PRKACB/PLIN1/MAPK13/PPARG/GRB2/KDM3A/PNPLA2/NDUFA3/ADCY3/UQCR11/ACSL5/PPARGC1A/LIPE/NDUFS3/ACTB/PRKAA1/COX7A1/SLC25A20/NDUFA9/NDUFB3/UQCRQ/NPR1/NDUFB5/UQCR10/SMARCC2/NDUFA1/RPS6KB1/NDUFB11/FGFR1/NDUFB2/COX5A/SMARCD3/NDUFAF1/COX7B/SMARCD2	37
KEGG	hsa04744	Phototransduction	2/1765	29/8135	0.9926	1	0.6259	CALML4/GNB1	2
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	14/1765	109/8135	0.9939	1	0.6259	NXF1/GTPBP4/WDR43/NXT1/FBL/MPHOSPH10/REXO2/CSNK2A2/RAN/UTP14A/MDN1/NHP2/FCF1/NAT10	14
KEGG	hsa00030	Pentose phosphate pathway	2/1765	30/8135	0.994	1	0.6259	FBP1/TALDO1	2
KEGG	hsa00140	Steroid hormone biosynthesis	6/1765	61/8135	0.9956	1	0.6259	AKR1C1/COMT/HSD11B1/HSD17B8/SRD5A1/CYP11A1	6
KEGG	hsa05034	Alcoholism	27/1765	187/8135	0.9958	1	0.6259	FOSB/CALML4/PRKACB/ATF4/MAOA/NTRK2/GRB2/GNG5/PPP1CA/SLC29A3/SLC6A3/GNAI2/HDAC1/PPP1CB/PDYN/GNG12/RAF1/SLC29A1/PKIA/GNG10/HDAC3/MAOB/GNB1/MAPK3/MAPK1/DRD1/GNG7	27
KEGG	hsa00830	Retinol metabolism	7/1765	68/8135	0.9958	1	0.6259	ADH1B/DHRS9/ADH1C/AOX1/ADH5/CYP26B1/DHRS3	7
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/1765	23/8135	0.9964	1	0.6259	FUT4	1
KEGG	hsa03020	RNA polymerase	1/1765	34/8135	0.9998	1	0.6259	POLR1E	1
KEGG	hsa04080	Neuroactive ligand-receptor interaction	50/1765	353/8135	0.9999	1	0.6259	ADM/EDNRB/GZMA/AGTR1/PARD3/APLNR/GHR/PTAFR/P2RX7/P2RX5/LEP/NPY1R/FPR3/C3AR1/PTH1R/S1PR4/P2RY6/BDKRB2/P2RX4/MCHR1/ADRA2A/THRB/PDYN/CALCRL/LPAR1/LPAR6/GRM6/F2R/FPR1/TACR1/GAL/GABRA2/P2RY10/HCRTR2/ADRA2C/P2RY13/SCT/P2RY2/GRM3/GLRB/LPAR2/VIPR2/CHRNA9/BDKRB1/GLP1R/THRA/C5/C5AR1/DRD1/NMU	50
KEGG	hsa05033	Nicotine addiction	1/1765	40/8135	0.9999	1	0.6259	GABRA2	1
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	1/1765	66/8135	1	1	0.6259	GATC	1
KEGG	hsa04740	Olfactory transduction	16/1765	440/8135	1	1	0.6259	CALML4/PRKACB/ARRB2/RGS2/ADCY3/SLC8A1/NCALD/PDE2A/ARRB1/PDE1A/OR2C1/GNB1/OR3A1/OR7A10/GNAL/GNG7	16