ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04062	Chemokine signaling pathway	68/1364	192/8135	1.991e-10	5.958e-08	3.854e-08	XCL1/CCL18/CXCL13/PLCG2/FGR/RAC2/CCL13/PLCB1/GNG12/CCL5/CXCL9/CXCL10/NFKBIA/CCR5/CCR2/NCF1/CCR1/MAPK3/WAS/CXCL12/PRKCB/CCL7/ITK/CXCR4/GNG10/GRK5/ARRB1/CCL8/CHUK/LYN/STAT1/CXCL6/CCL20/CX3CR1/CCR7/CXCL1/ADCY8/GSK3B/RAP1B/CCL23/RASGRP2/BAD/CXCL11/JAK2/CXCL3/CCL4/VAV2/KRAS/CXCL2/CDC42/SHC1/MAP2K1/ADCY7/CXCL8/PIK3R3/ADCY6/TIAM1/PF4/DOCK2/CCL19/PTK2/CXCR6/CX3CL1/PARD3/PIK3R2/NRAS/GRK6/AKT2	68
KEGG	hsa04662	B cell receptor signaling pathway	38/1364	82/8135	3.589e-10	5.958e-08	3.854e-08	PLCG2/RAC2/SYK/LILRB2/LILRB3/FCGR2B/CD79A/NFKBIA/CD19/MAPK3/RASGRP3/PRKCB/CD72/CHUK/LILRA2/LYN/BLNK/NFKBIE/LILRB1/GSK3B/BCL10/LILRB4/MALT1/PTPN6/VAV2/KRAS/PPP3CA/MAP2K1/INPP5D/CD81/INPPL1/PIK3R3/CD79B/PIK3R2/NRAS/DAPP1/AKT2/IFITM1	38
KEGG	hsa04064	NF-kappa B signaling pathway	44/1364	104/8135	5.764e-10	6.379e-08	4.126e-08	LCK/PLCG2/CCL13/SYK/TNFAIP3/NFKBIA/TRAF3/MYD88/ZAP70/UBE2I/CXCL12/PRKCB/LAT/BCL2A1/TRAF1/PRKCQ/BIRC3/RELB/ICAM1/CD40/CHUK/LYN/CD14/BLNK/PARP1/LBP/CXCL1/LY96/BCL10/TNFRSF11A/CSNK2A2/CXCL3/MALT1/CD40LG/IRAK4/CCL4/CXCL2/NFKB2/TICAM1/CXCL8/CCL19/LTB/DDX58/EDA2R	44
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	41/1364	97/8135	2.307e-09	1.802e-07	1.165e-07	PLCG2/RAC2/SYK/FCGR2B/PTPRC/NCF1/ACTR3/ASAP2/MAPK3/WAS/MARCKSL1/PLD1/ARPC2/ASAP3/PRKCB/LAT/FCGR3B/GSN/ARPC5L/WASF3/ARPC1A/LYN/LIMK2/DOCK1/FCGR2A/BIN1/VAV2/CDC42/GAB2/MAP2K1/INPP5D/INPPL1/PIK3R3/ACTR3B/MARCKS/PRKCE/PLA2G4C/PIK3R2/ARPC3/FCGR1A/AKT2	41
KEGG	hsa05416	Viral myocarditis	30/1364	60/8135	2.713e-09	1.802e-07	1.165e-07	RAC2/SGCA/HLA-DOB/PRF1/DAG1/ITGAL/SGCB/ICAM1/CD40/HLA-DMB/CYCS/HLA-A/HLA-E/HLA-F/HLA-C/HLA-DMA/ABL2/CD40LG/HLA-DPA1/HLA-B/HLA-DRB4/ITGB2/CASP9/HLA-G/LAMA2/CAV1/SGCD/HLA-DPB1/CCND1/CD86	30
KEGG	hsa04380	Osteoclast differentiation	49/1364	128/8135	3.713e-09	2.054e-07	1.329e-07	LCK/PLCG2/SYK/LILRB2/LILRB3/FCGR2B/LCP2/NFKBIA/IFNAR2/NCF1/PPARG/MAPK3/TNFRSF11B/TREM2/FCGR3B/RELB/SIRPG/CHUK/LILRA2/BLNK/STAT1/NCF4/FCGR2A/LILRB1/NCF2/SOCS1/LILRB4/FCGR2C/TNFRSF11A/IRF9/TGFB2/MAPK10/GAB2/PPP3CA/MAP2K1/NFKB2/PIK3R3/ITGB3/CSF1/MAPK13/CALCR/MITF/IFNG/PIK3R2/CSF1R/FCGR1A/SQSTM1/AKT2/MAP2K6	49
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	41/1364	100/8135	6.817e-09	3.233e-07	2.091e-07	XCL1/IL2RG/CCL18/CXCL13/TNFRSF1B/CCL13/CCL5/CXCL9/CXCL10/CCR5/CCR2/IL2RB/CCR1/CXCL12/TNFSF10/CCL7/CXCR4/CCL8/CXCL6/CCL20/CX3CR1/IL6R/CCR7/CXCL1/IL6/CCL23/CXCL11/IL2RA/CXCL3/CCL4/IL10RA/CXCL2/TNFRSF14/IL10RB/CXCL8/PF4/IL18RAP/CSF1/CCL19/CX3CL1/CSF1R	41
KEGG	hsa05144	Malaria	26/1364	50/8135	1.082e-08	4.489e-07	2.904e-07	SDC1/LRP1/ITGAL/SDC2/THBS4/MYD88/TLR2/KLRB1/GYPC/CR1/ICAM1/CD40/SELE/IL6/PECAM1/CD40LG/TGFB2/COMP/CD81/HBB/MET/CXCL8/ITGB2/HGF/IFNG/THBS1	26
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	71/1364	222/8135	1.242e-08	4.583e-07	2.964e-07	IL2RG/LCK/IL15RA/CD3D/HLA-DOB/NFKBIA/PTTG1/ITGAL/IL2RB/SMAD3/CD3E/MAPK3/IL15/CDKN2C/RELB/ICAM1/CD40/CHUK/CDC20/CCNE1/HLA-DMB/HLA-A/HLA-E/HLA-F/ADCY8/TLN2/IL6/HLA-C/CD3G/HLA-DMA/CANX/IL2RA/TGFB2/KRAS/CCNB2/MSX1/MAPK10/PPP3CA/HLA-DPA1/RANBP3/HLA-B/MAP2K1/NFKB2/SLC25A6/KAT5/ADCY7/ATR/HLA-DRB4/PIK3R3/ADCY6/ITGB2/EGR2/BUB1B/CHEK2/HLA-G/E2F3/CREB3L2/CREB3/CCNA2/CCND2/ESPL1/PIK3R2/IL1R2/NRAS/B2M/CRTC1/HLA-DPB1/CCND3/AKT2/CRTC3/CCND1	71
KEGG	hsa05169	Epstein-Barr virus infection	66/1364	202/8135	1.593e-08	5.287e-07	3.42e-07	RUNX3/TAP1/PLCG2/SYK/CD3D/TNFAIP3/HLA-DOB/CXCL10/NFKBIA/TRAF3/ITGAL/IFNAR2/CD19/MYD88/TAPBP/CD3E/SAP30L/TLR2/CD247/RELB/ICAM1/CD40/CHUK/CCNE1/LYN/HLA-DMB/CYCS/BLNK/STAT1/HLA-A/NFKBIE/OAS2/HLA-E/HLA-F/IL6/IRF7/HLA-C/CD3G/HLA-DMA/IRAK4/IRF9/MAPK10/HLA-DPA1/HLA-B/NFKB2/HDAC1/HLA-DRB4/PIK3R3/CASP9/PSMC3/HES1/MAPK13/HLA-G/E2F3/CCNA2/FAS/DDX58/CCND2/PIK3R2/CD44/B2M/HLA-DPB1/CCND3/AKT2/MAP2K6/CCND1	66
KEGG	hsa04640	Hematopoietic cell lineage	38/1364	99/8135	1.936e-07	5.843e-06	3.779e-06	CD38/IL11RA/TFRC/IL7R/CD2/CD3D/HLA-DOB/CD19/KIT/CD3E/CD8A/IL4R/CR1/CD7/CD14/IL7/KITLG/HLA-DMB/IL6R/ITGA4/IL6/CD3G/HLA-DMA/IL2RA/IL3RA/HLA-DPA1/CD9/CD37/HLA-DRB4/ITGB3/CSF1/ITGA3/MS4A1/CD44/IL1R2/CSF1R/FCGR1A/HLA-DPB1	38
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	35/1364	89/8135	2.94e-07	8.135e-06	5.262e-06	BATF/LCK/RASGRP1/CD3D/NFKBIA/MYD88/CD3E/MAPK3/ZAP70/TLR2/LAT/PRKCQ/CD247/CHUK/STAT1/NFKBIE/CD3G/CSNK2A2/JAK2/PTPN6/KRAS/PPP3CA/EGFR/MAP2K1/TICAM1/PTPN11/PIK3R3/HIF1A/MAPK13/IFNG/PIK3R2/NRAS/AKT2/MAP2K6/ALK	35
KEGG	hsa04658	Th1 and Th2 cell differentiation	35/1364	92/8135	7.511e-07	1.888e-05	1.221e-05	RUNX3/IL2RG/LCK/CD3D/HLA-DOB/NFKBIA/IL2RB/CD3E/MAPK3/ZAP70/LAT/IL4R/PRKCQ/CD247/CHUK/HLA-DMB/STAT1/NFKBIE/CD3G/HLA-DMA/STAT4/IL2RA/JAK2/TBX21/MAPK10/PPP3CA/HLA-DPA1/MAML1/HLA-DRB4/IL12RB1/NOTCH1/MAPK13/IFNG/HLA-DPB1/STAT6	35
KEGG	hsa04660	T cell receptor signaling pathway	38/1364	104/8135	8.381e-07	1.888e-05	1.221e-05	LCK/RASGRP1/CD3D/LCP2/NFKBIA/PTPRC/CD3E/MAPK3/ZAP70/CD8A/LAT/ITK/PRKCQ/CD247/CHUK/MAP3K8/NFKBIE/CBLB/GSK3B/BCL10/CD3G/MALT1/CD40LG/PTPN6/VAV2/KRAS/CDC42/MAPK10/PPP3CA/MAP2K1/PIK3R3/MAPK13/IFNG/PIK3R2/NRAS/PAK2/AKT2/CTLA4	38
KEGG	hsa04659	Th17 cell differentiation	39/1364	108/8135	8.53e-07	1.888e-05	1.221e-05	IL2RG/LCK/IL27RA/CD3D/IL21R/HLA-DOB/NFKBIA/IL2RB/SMAD3/CD3E/MAPK3/ZAP70/LAT/IL4R/PRKCQ/CD247/CHUK/HLA-DMB/STAT1/NFKBIE/IL6R/IL6/CD3G/HLA-DMA/RORA/IL2RA/JAK2/TBX21/MAPK10/PPP3CA/HLA-DPA1/RXRA/HLA-DRB4/IL12RB1/HIF1A/MAPK13/IFNG/HLA-DPB1/STAT6	39
KEGG	hsa04015	Rap1 signaling pathway	63/1364	210/8135	1.06e-06	2.072e-05	1.34e-05	RAC2/PLCB1/LCP2/EFNA5/FPR1/ITGAL/KIT/MAPK3/MAGI2/VEGFA/KRIT1/RALA/RASGRP3/PRKCB/LAT/PFN2/ANGPT1/ANGPT2/KITLG/PLCE1/ID1/PDGFD/F2R/SIPA1L1/FGF7/LPAR1/ADCY8/TLN2/RAP1B/PRKD2/RASGRP2/VAV2/KRAS/PGF/EFNA1/CDC42/FGF2/EGFR/TEK/ENAH/MAP2K1/SIPA1L3/ADCY7/MET/PIK3R3/ADCY6/ITGB2/TIAM1/ITGB3/HGF/CSF1/MAPK13/RALGDS/PRKCI/PARD3/EPHA2/PIK3R2/THBS1/NRAS/CSF1R/AKT2/MAP2K6/GNAS	63
KEGG	hsa05221	Acute myeloid leukemia	28/1364	67/8135	1.061e-06	2.072e-05	1.34e-05	TCF7L2/PIM2/TCF7L1/CEBPA/KIT/MAPK3/ZBTB16/BCL2A1/CHUK/CD14/BAD/PIM1/LEF1/PML/KRAS/TCF7/RUNX1T1/MAP2K1/PIK3R3/PPARD/CCNA2/PIK3R2/NRAS/DUSP6/CSF1R/FCGR1A/AKT2/CCND1	28
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	59/1364	194/8135	1.422e-06	2.622e-05	1.696e-05	TCF7L2/PLCG2/MICB/SYK/GNG12/TCF7L1/NFKBIA/CCR5/TRAF3/IFNAR2/CCR1/MAPK3/VEGFA/GNG10/ANGPT2/ICAM1/CHUK/LYN/CYCS/STAT1/HLA-A/HLA-E/HLA-F/CXCL1/GSK3B/IL6/IRF7/HLA-C/LEF1/JAK2/CXCL3/IRF9/KRAS/CXCL2/MAPK10/FGF2/PPP3CA/TCF7/HLA-B/MAP2K1/TICAM1/ITPR1/CXCL8/PIK3R3/CASP9/HIF1A/MAPK13/HLA-G/E2F3/FAS/PIK3R2/NRAS/MAPKAPK2/CLEC2B/RPS27A/AKT2/MAP2K6/CCND1/CD86	59
KEGG	hsa05330	Allograft rejection	19/1364	38/8135	2.288e-06	3.808e-05	2.463e-05	HLA-DOB/PRF1/GZMB/CD40/HLA-DMB/HLA-A/HLA-E/HLA-F/HLA-C/HLA-DMA/CD40LG/HLA-DPA1/HLA-B/HLA-DRB4/HLA-G/FAS/IFNG/HLA-DPB1/CD86	19
KEGG	hsa04514	Cell adhesion molecules	48/1364	149/8135	2.294e-06	3.808e-05	2.463e-05	PTPRF/SDC1/CD2/HLA-DOB/PTPRC/ITGAL/NEO1/SDC2/VCAN/ICAM3/CD8A/PTPRM/ICAM1/CD40/HLA-DMB/SELE/HLA-A/HLA-E/ITGA4/JAM3/HLA-F/ITGAV/HLA-C/PECAM1/ITGB7/HLA-DMA/CDH2/CD40LG/SDC3/NLGN4X/SELL/HLA-DPA1/HLA-B/PDCD1LG2/SELPLG/HLA-DRB4/ITGB2/CD6/CLDN11/CDH5/CNTN1/HLA-G/CD99/CADM3/ICAM2/HLA-DPB1/CD86/CTLA4	48
KEGG	hsa05165	Human papillomavirus infection	88/1364	331/8135	2.818e-06	4.455e-05	2.881e-05	TCF7L2/MX2/TCF7L1/FZD4/TRAF3/IFNAR2/THBS4/IRF1/WNT5B/MAPK3/FOXO1/VEGFA/LAMB2/FZD2/FZD7/CHUK/CCNE1/LAMC3/STAT1/FZD6/HLA-A/HLA-E/PPP2CA/ITGA4/HLA-F/GSK3B/ITGAV/HLA-C/ITGB7/BAD/PPP2R5D/PTGER4/PPP2R1A/HEY1/IRF9/WNT5A/KRAS/LFNG/COMP/ITGB5/ITGA7/CDC42/LLGL2/TUBG1/EGFR/TCF7/HLA-B/MAP2K1/MAML1/HDAC1/TICAM1/TSC1/ATR/WNT11/LAMB3/PIK3R3/LAMA4/NOTCH1/ITGB3/MPP5/HES1/HLA-G/WNT10B/CREB3L2/PTK2/PRKCI/HEY2/CREB3/PARD3/CCNA2/LAMA2/ITGA3/FAS/TUBG2/PPP2R1B/CCND2/PIK3R2/THBS1/NRAS/TADA3/MX1/TSC2/CCND3/AKT2/RHEB/CCND1/OASL/GNAS	88
KEGG	hsa04668	TNF signaling pathway	38/1364	112/8135	6.625e-06	9.444e-05	6.109e-05	TNFRSF1B/CCL5/TNFAIP3/CXCL10/NFKBIA/TRAF3/IRF1/MAPK3/TRAF1/IL15/NOD2/BIRC3/ICAM1/CHUK/MAP3K8/MAP3K5/CXCL6/CCL20/SELE/CXCL1/IL6/EDN1/CXCL3/CXCL2/MAPK10/MAP2K1/PIK3R3/CASP10/CSF1/MAPK13/CREB3L2/CREB3/CX3CL1/FAS/PIK3R2/AKT2/MAP2K6/CEBPB	38
KEGG	hsa05145	Toxoplasmosis	38/1364	112/8135	6.625e-06	9.444e-05	6.109e-05	HLA-DOB/NFKBIA/CCR5/MYD88/MAPK3/TLR2/LAMB2/BIRC3/CD40/CHUK/HLA-DMB/CYCS/LAMC3/STAT1/LY96/SOCS1/ALOX5/BAD/HLA-DMA/JAK2/CD40LG/IRAK4/TGFB2/IL10RA/MAPK10/HLA-DPA1/IL10RB/LAMB3/HLA-DRB4/CASP9/LAMA4/MAPK13/LAMA2/IFNG/HSPA6/HLA-DPB1/AKT2/MAP2K6	38
KEGG	hsa04060	Cytokine-cytokine receptor interaction	79/1364	295/8135	6.827e-06	9.444e-05	6.109e-05	CSF2RB/XCL1/IL2RG/IL11RA/CCL18/IL7R/IL27RA/CXCL13/TNFRSF17/TNFRSF1B/CCL13/CD27/CCL5/IL15RA/CXCL9/IL21R/CXCL10/CCR5/GHR/BMP4/CCR2/IL32/IFNAR2/IL2RB/CCR1/TNFRSF11B/CXCL12/TNFSF10/CCL7/CXCR4/IL4R/IL15/CD40/CCL8/IL7/CXCL6/CCL20/CX3CR1/IL6R/CCR7/CXCL1/IL6/IL16/CCL23/GDF15/CXCL11/TNFRSF11A/IL2RA/CXCL3/CD40LG/CCL4/IL3RA/TGFB2/CD70/IL10RA/IL1RN/CXCL2/IL17RC/BMPR1A/TNFRSF14/IL10RB/CXCL8/BMP5/PF4/IL12RB1/IL18RAP/CSF1/CCL19/CXCR6/LTB/CX3CL1/FAS/IFNG/IL1R2/LIFR/CSF1R/TNFSF8/EDA2R/TNFRSF25	79
KEGG	hsa05140	Leishmaniasis	29/1364	77/8135	8.324e-06	0.0001095	7.08e-05	HLA-DOB/NFKBIA/NCF1/MYD88/MAPK3/MARCKSL1/TLR2/PRKCB/CR1/FCGR3B/HLA-DMB/STAT1/NCF4/FCGR2A/ITGA4/NCF2/HLA-DMA/FCGR2C/JAK2/IRAK4/PTPN6/TGFB2/HLA-DPA1/HLA-DRB4/ITGB2/MAPK13/IFNG/FCGR1A/HLA-DPB1	29
KEGG	hsa04151	PI3K-Akt signaling pathway	91/1364	354/8135	8.573e-06	0.0001095	7.08e-05	IL2RG/IL7R/SYK/GNG12/EFNA5/GHR/PHLPP1/IFNAR2/CD19/THBS4/KIT/IL2RB/MAPK3/MAGI2/VEGFA/TLR2/NTRK2/LAMB2/IL4R/ANGPT1/DDIT4/GNG10/ANGPT2/CHUK/CCNE1/PCK1/IL7/KITLG/LAMC3/PDGFD/F2R/ERBB2/IL6R/PPP2CA/ITGA4/FGF7/LPAR1/GSK3B/IL6/ITGAV/ITGB7/BAD/PPP2R5D/PPP2R1A/IL2RA/JAK2/IL3RA/KRAS/PGF/COMP/GYS1/NR4A1/EFNA1/ITGB5/ITGA7/FGF2/EGFR/TEK/MAP2K1/RXRA/TSC1/PCK2/LAMB3/MET/PIK3R3/CASP9/LAMA4/ITGB3/HGF/CSF1/CREB3L2/PTK2/CREB3/LAMA2/NTF3/ITGA3/EPHA2/PPP2R1B/CCND2/PIK3R2/THBS1/YWHAQ/NRAS/CSF1R/TSC2/SGK2/CCND3/AKT2/RHEB/CCND1/EREG	91
KEGG	hsa05205	Proteoglycans in cancer	59/1364	205/8135	9.839e-06	0.000121	7.825e-05	FLNB/SDC1/PLCG2/HBEGF/FZD4/SDC2/WNT5B/MAPK3/VEGFA/TLR2/CTSL/PRKCB/FZD2/HCLS1/FZD7/PLCE1/FZD6/ANK3/ERBB2/HSPB2/ANK2/ITGAV/PTPN6/WNT5A/TGFB2/VAV2/KRAS/ITGB5/CDC42/FGF2/EGFR/MAP2K1/TIMP3/SLC9A1/PPP1CC/WNT11/PTPN11/MET/ITPR1/PIK3R3/HPSE/TWIST1/RDX/TIAM1/ITGB3/HGF/HIF1A/MAPK13/WNT10B/PTK2/CD63/FAS/CAV1/PIK3R2/THBS1/CD44/NRAS/AKT2/CCND1	59
KEGG	hsa05132	Salmonella infection	68/1364	249/8135	1.488e-05	0.0001764	0.0001141	TCF7L2/FLNB/TCF7L1/NFKBIA/PTPRC/RHOH/ACTR3/MYD88/TUBA4A/MAPK3/TLR2/RALA/CYFIP2/ARPC2/TNFSF10/PFN2/ARPC5L/BIRC3/WASF3/FYCO1/NAIP/CHUK/ARPC1A/CD14/STX10/CYCS/DYNC2LI1/KPNA3/LY96/AHNAK/IL6/LEF1/KLC1/IRAK4/DCTN3/MYL12A/DYNLT1/CDC42/MAPK10/DCTN2/TCF7/MAP2K1/TUBB6/CYTH1/AHNAK2/CASP1/NCKAP1L/CXCL8/EXOC7/RIPK2/SKP1/ACTR3B/KIF5C/MAPK13/TXN/CSE1L/MYL12B/CYTH3/VPS16/TXN2/RHOG/ARPC3/DYNC1H1/MYL9/AKT2/MAP2K6/ABI1/PIK3C2A	68
KEGG	hsa04940	Type I diabetes mellitus	19/1364	43/8135	2.22e-05	0.0002496	0.0001615	HLA-DOB/PRF1/GZMB/HLA-DMB/HLA-A/HLA-E/HLA-F/HLA-C/HLA-DMA/CPE/HLA-DPA1/HLA-B/HLA-DRB4/HLA-G/FAS/IFNG/HLA-DPB1/ICA1/CD86	19
KEGG	hsa04145	Phagosome	46/1364	152/8135	2.329e-05	0.0002496	0.0001615	TFRC/TAP1/COLEC12/MRC2/FCGR2B/HLA-DOB/NCF1/THBS4/TUBA4A/CORO1A/TLR2/CTSL/FCGR3B/CD14/HLA-DMB/HLA-A/NCF4/FCGR2A/HLA-E/HLA-F/CLEC7A/NCF2/ITGAV/HLA-C/HLA-DMA/FCGR2C/CD209/CANX/COMP/ITGB5/HLA-DPA1/HLA-B/TUBB6/STX12/HLA-DRB4/CTSS/ITGB2/ITGB3/HLA-G/LAMP2/LAMP1/THBS1/OLR1/FCGR1A/DYNC1H1/HLA-DPB1	46
KEGG	hsa05417	Lipid and atherosclerosis	60/1364	215/8135	2.331e-05	0.0002496	0.0001615	XBP1/PLCB1/CCL5/NFKBIA/TRAF3/NCF1/PPARG/MYD88/MAPK3/TLR2/ABCG1/TNFSF10/ATF6/ICAM1/CD40/CHUK/LYN/CD14/MAP3K5/CYCS/SELE/NCF4/LBP/CXCL1/LY96/NCF2/GSK3B/IL6/RAP1B/IRF7/BAD/TANK/JAK2/CXCL3/CD40LG/IRAK4/VAV2/KRAS/MMP1/CXCL2/CDC42/MAPK10/PPP3CA/RXRA/CASP1/TICAM1/ITPR1/CXCL8/PIK3R3/CASP9/MAPK13/PTK2/FAS/HSPA6/VLDLR/PIK3R2/NRAS/OLR1/AKT2/MAP2K6	60
KEGG	hsa05323	Rheumatoid arthritis	32/1364	93/8135	2.53e-05	0.0002624	0.0001697	CCL5/HLA-DOB/ITGAL/VEGFA/TLR2/CXCL12/CTSL/ANGPT1/IL15/ICAM1/HLA-DMB/CXCL6/CCL20/CXCL1/IL6/HLA-DMA/TNFRSF11A/CXCL3/TGFB2/MMP1/CXCL2/HLA-DPA1/TEK/HLA-DRB4/CXCL8/ITGB2/CSF1/LTB/IFNG/HLA-DPB1/CD86/CTLA4	32
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	41/1364	131/8135	2.683e-05	0.0002699	0.0001746	LCK/PLCG2/MICB/RAC2/SYK/LCP2/PRF1/GZMB/CD48/ITGAL/IFNAR2/MAPK3/ZAP70/SH2D1A/TNFSF10/PRKCB/LAT/FCGR3B/CD247/ICAM1/HLA-A/HLA-E/HLA-C/PTPN6/VAV2/KRAS/SHC1/PPP3CA/HLA-B/MAP2K1/PTPN11/PIK3R3/ITGB2/HLA-G/FAS/IFNG/KIR2DS5/PIK3R2/NRAS/ULBP2/ICAM2	41
KEGG	hsa04210	Apoptosis	42/1364	136/8135	3.069e-05	0.0002997	0.0001938	CSF2RB/NFKBIA/PRF1/GZMB/CTSB/CTSF/TUBA4A/MAPK3/PARP3/LMNB1/CTSH/DAXX/CTSL/TNFSF10/CTSC/BCL2A1/TRAF1/BIRC3/CHUK/MAP3K5/CYCS/PARP1/BAD/CTSO/IL3RA/DFFB/KRAS/CAPN2/MAPK10/MAP2K1/LMNA/PTPN13/ITPR1/PIK3R3/CTSS/CASP9/CASP10/CTSW/FAS/PIK3R2/NRAS/AKT2	42
KEGG	hsa05163	Human cytomegalovirus infection	61/1364	225/8135	5.129e-05	0.0004866	0.0003147	TAP1/RAC2/PLCB1/GNG12/CCL5/NFKBIA/CCR5/TAPBP/CCR1/MAPK3/VEGFA/CXCL12/PRKCB/CXCR4/GNG10/CHUK/CYCS/HLA-A/HLA-E/IL6R/HLA-F/ADCY8/GSK3B/IL6/ITGAV/HLA-C/GNA11/PTGER4/CCL4/KRAS/IL10RA/PPP3CA/EGFR/HLA-B/MAP2K1/TSC1/IL10RB/ADCY7/ITPR1/CXCL8/PIK3R3/ADCY6/CASP9/ITGB3/MAPK13/HLA-G/E2F3/CREB3L2/PTK2/CREB3/CX3CL1/FAS/PIK3R2/NRAS/B2M/TSC2/AKT2/MAP2K6/RHEB/CCND1/GNAS	61
KEGG	hsa05162	Measles	42/1364	139/8135	5.427e-05	0.000487	0.000315	IL2RG/MX2/CD3D/FCGR2B/SLAMF1/TNFAIP3/NFKBIA/TRAF3/IFNAR2/MYD88/IL2RB/CD3E/TLR2/CHUK/CCNE1/CYCS/STAT1/OAS2/CBLB/GSK3B/IL6/IRF7/BAD/CD3G/CSNK2A2/CD209/IL2RA/IRAK4/IRF9/MAPK10/IFIH1/PIK3R3/CASP9/FAS/HSPA6/DDX58/CCND2/PIK3R2/MX1/CCND3/AKT2/CCND1	42
KEGG	hsa05418	Fluid shear stress and atherosclerosis	42/1364	139/8135	5.427e-05	0.000487	0.000315	SDC1/RAC2/BMP4/NQO1/GSTA4/NCF1/SDC2/VEGFA/GSTT1/CTSL/ICAM1/CHUK/MAP3K5/SELE/NCF2/ITGAV/PECAM1/EDN1/KEAP1/SUMO4/MAPK10/BMPR1A/GSTM2/MAPK7/GSTM1/PIK3R3/ITGB3/CDH5/MAPK13/TXN/PTK2/ASS1/MGST3/IFNG/CAV1/TXN2/PIK3R2/IL1R2/SQSTM1/AKT2/MAP2K6/ARHGEF2	42
KEGG	hsa05170	Human immunodeficiency virus 1 infection	58/1364	212/8135	5.907e-05	0.0005076	0.0003283	TAP1/PLCG2/TNFRSF1B/RAC2/GNG12/CD3D/APOBEC3G/NFKBIA/CCR5/MYD88/TAPBP/CD3E/MAPK3/TLR2/SAMHD1/PRKCB/CXCR4/CD247/GNG10/CHUK/LIMK2/CYCS/HLA-A/AP1B1/HLA-E/HLA-F/HLA-C/GNA11/BAD/CD3G/DDB1/IRAK4/KRAS/CCNB2/MAPK10/PPP3CA/HLA-B/MAP2K1/ATR/AP1G2/ITPR1/PIK3R3/CASP9/SKP1/CUL4B/APOBEC3F/CDK1/MAPK13/HLA-G/PTK2/FAS/PIK3R2/NRAS/B2M/PAK2/CCNB1/AKT2/MAP2K6	58
KEGG	hsa05332	Graft-versus-host disease	18/1364	42/8135	5.989e-05	0.0005076	0.0003283	HLA-DOB/PRF1/GZMB/HLA-DMB/HLA-A/HLA-E/HLA-F/IL6/HLA-C/HLA-DMA/HLA-DPA1/HLA-B/HLA-DRB4/HLA-G/FAS/IFNG/HLA-DPB1/CD86	18
KEGG	hsa05152	Tuberculosis	51/1364	180/8135	6.116e-05	0.0005076	0.0003283	SYK/MRC2/FCGR2B/HLA-DOB/MYD88/MAPK3/CORO1A/TLR2/RFX5/LSP1/CR1/FCGR3B/NOD2/CD14/HLA-DMB/CYCS/STAT1/FCGR2A/LBP/CLEC7A/BCL10/IL6/BAD/HLA-DMA/CD74/ITGAX/FCGR2C/CD209/JAK2/MALT1/IRAK4/TGFB2/IL10RA/MAPK10/PPP3CA/HLA-DPA1/IL10RB/HLA-DRB4/CTSS/ITGB2/CASP9/RIPK2/CASP10/MAPK13/LAMP2/LAMP1/IFNG/FCGR1A/HLA-DPB1/AKT2/CEBPB	51
KEGG	hsa04218	Cellular senescence	45/1364	156/8135	0.0001028	0.0008327	0.0005386	SMAD3/MAPK3/FOXO1/CCNE1/HLA-A/HLA-E/HLA-F/IL6/HLA-C/TGFB2/KRAS/CCNB2/CAPN2/PPP3CA/HLA-B/MAP2K1/SLC25A6/TSC1/PPP1CC/ATR/ITPR1/CXCL8/PIK3R3/HIPK1/NBN/CHEK2/CACNA1D/CDK1/MAPK13/HLA-G/E2F3/CCNA2/ZFP36L2/CCND2/PIK3R2/NRAS/MAPKAPK2/SQSTM1/TSC2/CCND3/CCNB1/AKT2/MAP2K6/RHEB/CCND1	45
KEGG	hsa04010	MAPK signaling pathway	74/1364	294/8135	0.0001237	0.0009774	0.0006322	FLNB/RAC2/GNG12/RASGRP1/EFNA5/HSPB1/MYD88/KIT/PTPN7/MAPK3/VEGFA/RASGRP3/DAXX/NTRK2/MAP4K1/DUSP5/PRKCB/NLK/ANGPT1/RELB/ANGPT2/ARRB1/CHUK/MAP3K8/CD14/MAP3K5/KITLG/DUSP2/PDGFD/ERBB2/RPS6KA1/FGF7/RAP1B/RASGRP2/IRAK4/TGFB2/KRAS/PGF/NR4A1/EFNA1/CDC42/MAPK10/FGF2/PPP3CA/EGFR/TEK/MAP2K1/NFKB2/MAPK7/MET/MAP3K11/HGF/CACNA1D/CSF1/MAPK13/DUSP3/NTF3/PLA2G4C/FAS/HSPA6/EPHA2/CACNG3/CACNB2/NRAS/CACNA1F/MAPKAPK2/DUSP6/CSF1R/PAK2/AKT2/MAP2K6/MAP3K4/MECOM/EREG	74
KEGG	hsa05164	Influenza A	48/1364	171/8135	0.000128	0.0009882	0.0006392	MX2/CCL5/HLA-DOB/CXCL10/NFKBIA/TRAF3/IFNAR2/TPSAB1/MYD88/MAPK3/TPSB2/TNFSF10/PRKCB/ICAM1/CHUK/HLA-DMB/CYCS/STAT1/OAS2/IL6/IRF7/HLA-DMA/PML/JAK2/IRAK4/IRF9/KPNA2/NXF3/HLA-DPA1/MAP2K1/CASP1/SLC25A6/TICAM1/IFIH1/HLA-DRB4/CXCL8/PIK3R3/CASP9/FAS/IFNG/DDX58/PIK3R2/NXT1/MX1/HLA-DPB1/CCND3/AKT2/NLRX1	48
KEGG	hsa05171	Coronavirus disease - COVID-19	61/1364	232/8135	0.000133	0.001004	0.0006492	PLCG2/SYK/MX2/HBEGF/F13A1/CXCL10/NFKBIA/C7/TRAF3/IFNAR2/AGTR1/CFD/MYD88/MAPK3/TLR2/C6/C5AR1/PRKCB/CFB/RPLP0/CHUK/RPL15/STAT1/OAS2/FCGR2A/IL6R/IL6/RPL8/RPL7/IRAK4/RPS18/RPS28/RPS23/IRF9/RPL41/RPS9/RPS15/MMP1/RPL3/RPL12/MAPK10/EGFR/RPL24/C3AR1/CASP1/RPLP1/IFIH1/RPL29/CXCL8/PIK3R3/MAPK13/RPL30/DDX58/RPS5/RPL34/PIK3R2/RPL10A/RPL35A/RPS27A/MX1/RPL9	61
KEGG	hsa05340	Primary immunodeficiency	16/1364	38/8135	0.000197	0.001452	0.0009392	IL2RG/LCK/IL7R/TAP1/CD3D/CD79A/ADA/PTPRC/CD19/CD3E/ZAP70/CD8A/RFX5/CD40/BLNK/CD40LG	16
KEGG	hsa04936	Alcoholic liver disease	41/1364	142/8135	0.0002012	0.001452	0.0009392	TCF7L2/ALDH3A2/TCF7L1/NFKBIA/TRAF3/MYD88/ALDH7A1/FOXO1/ACADVL/C5AR1/ADIPOQ/CHUK/CD14/MAP3K5/ACACB/LBP/CXCL1/LY96/GSK3B/IL6/LEF1/CXCL3/IRAK4/SCD/CXCL2/MAPK10/IL17RC/TCF7/C3AR1/TICAM1/SREBF1/CXCL8/CAMKK2/MAPK13/ADH5/FABP1/ADH1C/FAS/AKT2/MAP2K6/CCND1	41
KEGG	hsa04612	Antigen processing and presentation	26/1364	78/8135	0.0002549	0.001801	0.001165	TAP1/HLA-DOB/CTSB/TAPBP/CD8A/RFX5/CTSL/HLA-DMB/HLA-A/HLA-E/HLA-F/HLA-C/HLA-DMA/CD74/CANX/HLA-DPA1/HLA-B/HLA-DRB4/CTSS/PSME1/HLA-G/IFNG/HSPA6/KIR2DS5/B2M/HLA-DPB1	26
KEGG	hsa04620	Toll-like receptor signaling pathway	32/1364	104/8135	0.0002821	0.001951	0.001262	CCL5/CXCL9/CXCL10/NFKBIA/TRAF3/IFNAR2/MYD88/MAPK3/TLR2/CD40/CHUK/MAP3K8/CD14/STAT1/LBP/LY96/IL6/IRF7/CXCL11/TOLLIP/IRAK4/CCL4/MAPK10/MAP2K1/TICAM1/CXCL8/PIK3R3/MAPK13/PIK3R2/AKT2/MAP2K6/CD86	32
KEGG	hsa04510	Focal adhesion	53/1364	201/8135	0.0003329	0.002255	0.001459	FLNB/RAC2/THBS4/MAPK3/VEGFA/PARVA/PRKCB/LAMB2/BIRC3/ARHGAP35/DOCK1/LAMC3/PDGFD/ERBB2/ITGA4/GSK3B/TLN2/RAP1B/ITGAV/ITGB7/BAD/VAV2/MYL12A/PGF/COMP/ITGB5/ITGA7/CDC42/CAPN2/MAPK10/SHC1/EGFR/MAP2K1/PPP1CC/LAMB3/MET/PIK3R3/LAMA4/ITGB3/HGF/PTK2/LAMA2/MYL12B/ITGA3/CAV1/CCND2/PIK3R2/THBS1/PAK2/CCND3/MYL9/AKT2/CCND1	53
KEGG	hsa04370	VEGF signaling pathway	21/1364	59/8135	0.0003592	0.002385	0.001543	PLCG2/RAC2/HSPB1/MAPK3/VEGFA/PRKCB/SH2D2A/BAD/KRAS/CDC42/PPP3CA/MAP2K1/PIK3R3/CASP9/MAPK13/PTK2/PLA2G4C/PIK3R2/NRAS/MAPKAPK2/AKT2	21
KEGG	hsa05135	Yersinia infection	39/1364	137/8135	0.000391	0.002545	0.001646	LCK/RAC2/LCP2/NFKBIA/ACTR3/MYD88/MAPK3/ZAP70/WAS/CD8A/ARPC2/WIPF1/LAT/ARPC5L/CHUK/ARPC1A/DOCK1/FCGR2A/ITGA4/RPS6KA1/GSK3B/IL6/IRAK4/VAV2/CDC42/MAPK10/MAP2K1/CASP1/TICAM1/CXCL8/PIK3R3/ACTR3B/MAPK13/PTK2/PIK3R2/RHOG/ARPC3/AKT2/MAP2K6	39
KEGG	hsa04014	Ras signaling pathway	59/1364	232/8135	0.000441	0.002816	0.001821	PLCG2/RAC2/GNG12/RASGRP1/EFNA5/PLA2G2D/RGL1/KIT/MAPK3/ZAP70/VEGFA/PLD1/RALA/RASGRP3/NTRK2/PRKCB/LAT/ANGPT1/GNG10/ANGPT2/CHUK/KITLG/PLCE1/PDGFD/FGF7/RAP1B/RASGRP2/BAD/ABL2/REL/KRAS/PGF/EFNA1/CDC42/MAPK10/GAB2/FGF2/SHC1/EGFR/TEK/MAP2K1/PTPN11/MET/PLA1A/PIK3R3/TIAM1/RALBP1/HGF/CSF1/RALGDS/PLA2G2F/NTF3/PLA2G4C/EPHA2/PIK3R2/NRAS/CSF1R/PAK2/AKT2	59
KEGG	hsa04810	Regulation of actin cytoskeleton	56/1364	218/8135	0.0004673	0.002927	0.001893	RAC2/GNG12/IQGAP2/ITGAL/ACTR3/MAPK3/CYFIP2/ARPC2/CXCL12/CXCR4/PFN2/GSN/ARPC5L/ARHGAP35/ARPC1A/PIP4K2B/LIMK2/DOCK1/PDGFD/F2R/ITGA4/FGF7/LPAR1/ITGAV/ITGB7/ITGAX/MYH10/VAV2/KRAS/MYL12A/ITGB5/ITGA7/CDC42/FGF2/EGFR/ENAH/MAP2K1/MYH11/SLC9A1/PPP1CC/NCKAP1L/PIK3R3/ITGB2/RDX/TIAM1/ACTR3B/ITGB3/PTK2/MYL12B/ITGA3/SSH3/PIK3R2/NRAS/ARPC3/PAK2/MYL9	56
KEGG	hsa05321	Inflammatory bowel disease	22/1364	65/8135	0.0005869	0.003609	0.002334	IL2RG/IL21R/HLA-DOB/SMAD3/TLR2/IL4R/NOD2/HLA-DMB/STAT1/IL6/HLA-DMA/STAT4/RORA/TGFB2/TBX21/HLA-DPA1/HLA-DRB4/IL12RB1/IL18RAP/IFNG/HLA-DPB1/STAT6	22
KEGG	hsa05134	Legionellosis	20/1364	57/8135	0.0006095	0.003611	0.002336	NFKBIA/MYD88/TLR2/CR1/NAIP/CD14/CYCS/CXCL1/IL6/CXCL3/CLK4/SAR1B/CXCL2/NFKB2/CASP1/CXCL8/ITGB2/CASP9/BCL2L13/HSPA6	20
KEGG	hsa05320	Autoimmune thyroid disease	19/1364	53/8135	0.0006107	0.003611	0.002336	HLA-DOB/PRF1/GZMB/CD40/HLA-DMB/HLA-A/HLA-E/HLA-F/HLA-C/HLA-DMA/CD40LG/HLA-DPA1/HLA-B/HLA-DRB4/HLA-G/FAS/HLA-DPB1/CD86/CTLA4	19
KEGG	hsa04360	Axon guidance	48/1364	182/8135	0.0006206	0.003611	0.002336	SEMA4D/PLCG2/RAC2/EFNA5/SEMA4A/NEO1/WNT5B/MAPK3/UNC5C/CXCL12/SEMA3E/SEMA3G/CXCR4/SLIT3/SEMA3A/TRPC1/LIMK2/EPHA3/GSK3B/WNT5A/KRAS/MYL12A/EFNA1/CDC42/PPP3CA/SEMA5A/ENAH/RYK/PLXNB2/PTPN11/MET/PIK3R3/DPYSL2/SEMA3C/PTK2/SEMA4C/PARD3/MYL12B/TRPC4/EPHA2/SSH3/PIK3R2/NRAS/SLIT2/PAK2/MYL9/ROBO1/ABLIM1	48
KEGG	hsa05225	Hepatocellular carcinoma	45/1364	168/8135	0.0006346	0.003611	0.002336	TCF7L2/PLCG2/TCF7L1/FZD4/NQO1/GSTA4/SMAD3/WNT5B/MAPK3/GSTT1/SMARCA2/PRKCB/FZD2/FRAT2/FZD7/FZD6/PHF10/GSK3B/LRP5/BAD/TXNRD2/LEF1/KEAP1/WNT5A/TGFB2/KRAS/SHC1/EGFR/TCF7/MAP2K1/GSTM2/WNT11/MET/GSTM1/PIK3R3/SMARCD3/HGF/WNT10B/E2F3/MGST3/ARID1A/PIK3R2/NRAS/AKT2/CCND1	45
KEGG	hsa04625	C-type lectin receptor signaling pathway	31/1364	104/8135	0.0006418	0.003611	0.002336	PLCG2/SYK/NFKBIA/IRF1/MAPK3/LSP1/EGR3/RELB/CHUK/STAT1/CBLB/CLEC7A/BCL10/IL6/CD209/MALT1/IRF9/KRAS/MAPK10/PPP3CA/NFKB2/CASP1/PTPN11/ITPR1/PIK3R3/EGR2/MAPK13/PIK3R2/NRAS/MAPKAPK2/AKT2	31
KEGG	hsa04917	Prolactin signaling pathway	23/1364	70/8135	0.0007147	0.003954	0.002558	IRF1/MAPK3/SOCS2/STAT1/GSK3B/SOCS1/TNFRSF11A/JAK2/SOCS6/KRAS/MAPK10/SHC1/MAP2K1/GALT/PIK3R3/MAPK13/CCND2/PIK3R2/NRAS/ELF5/CISH/AKT2/CCND1	23
KEGG	hsa05202	Transcriptional misregulation in cancer	50/1364	193/8135	0.0007502	0.004083	0.002641	GZMB/HOXA10/PPARG/CEBPA/IL2RB/FOXO1/MLF1/SIX1/NUPR1/PBX1/ZBTB16/BCL2A1/TRAF1/HOXA11/TSPAN7/CDKN2C/BIRC3/CD40/FLI1/FUT8/CD14/CDK14/LMO2/IL6/ITGB7/BCL11B/PML/PBX3/REL/RUNX1T1/RXRA/HDAC1/BMP2K/MET/BAIAP3/CXCL8/PTK2/MITF/CCNA2/MLLT3/MEIS1/CCND2/IL1R2/DUSP6/CSF1R/FCGR1A/CEBPB/PAX5/CD86/SSX2B	50
KEGG	hsa04630	JAK-STAT signaling pathway	43/1364	162/8135	0.001013	0.00534	0.003454	CSF2RB/IL2RG/IL11RA/IL7R/IL27RA/IL15RA/IL21R/GHR/IFNAR2/IL2RB/PTPN2/IL4R/IL15/SOCS2/IL7/STAT1/IL6R/SOCS1/IL6/PIM1/STAT4/IL2RA/JAK2/SOCS6/PTPN6/IL3RA/IRF9/FHL1/IL10RA/EGFR/IL10RB/PTPN11/PIK3R3/IL12RB1/IFNG/CCND2/PIK3R2/LIFR/CISH/CCND3/AKT2/CCND1/STAT6	43
KEGG	hsa05161	Hepatitis B	43/1364	162/8135	0.001013	0.00534	0.003454	NFKBIA/TRAF3/MYD88/SMAD3/MAPK3/TLR2/PRKCB/EGR3/CHUK/CCNE1/CYCS/STAT1/IL6/IRF7/BAD/STAT4/DDB1/JAK2/IRAK4/TGFB2/KRAS/MAPK10/MAP2K1/TICAM1/IFIH1/CXCL8/PIK3R3/EGR2/CASP9/CASP10/MAPK13/E2F3/CREB3L2/CREB3/CCNA2/FAS/DDX58/PIK3R2/YWHAQ/NRAS/AKT2/MAP2K6/STAT6	43
KEGG	hsa05212	Pancreatic cancer	24/1364	76/8135	0.001046	0.005424	0.003508	RAC2/SMAD3/MAPK3/VEGFA/PLD1/RALA/CHUK/STAT1/ERBB2/BAD/TGFB2/KRAS/CDC42/MAPK10/EGFR/MAP2K1/PIK3R3/CASP9/RALBP1/RALGDS/E2F3/PIK3R2/AKT2/CCND1	24
KEGG	hsa04664	Fc epsilon RI signaling pathway	22/1364	68/8135	0.001167	0.005961	0.003856	PLCG2/RAC2/SYK/LCP2/MAPK3/MS4A2/LAT/LYN/ALOX5/VAV2/KRAS/MAPK10/GAB2/MAP2K1/INPP5D/PIK3R3/MAPK13/PLA2G4C/PIK3R2/NRAS/AKT2/MAP2K6	22
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	24/1364	77/8135	0.001282	0.00645	0.004172	TCF7L2/SGCA/TCF7L1/DAG1/SGCB/ITGA4/ITGAV/ITGB7/LEF1/CDH2/DSC2/ATP2A3/ITGB5/ITGA7/TCF7/LMNA/ITGB3/CACNA1D/LAMA2/ITGA3/CACNG3/SGCD/CACNB2/CACNA1F	24
KEGG	hsa05131	Shigellosis	60/1364	247/8135	0.001363	0.006752	0.004367	PLCG2/PLCB1/CCL5/NFKBIA/FNBP1/ACTR3/MYD88/MAPK3/FOXO1/ARPC2/FNBP1L/PFN2/PRKCQ/ARPC5L/HCLS1/NAIP/CHUK/ARPC1A/CD14/RRAGA/DOCK1/CYCS/PLCE1/WIPI1/GSK3B/BCL10/TLN2/PLCD1/RRAGB/MALT1/TNIP1/MYL12A/CDC42/CAPN2/MAPK10/EGFR/CYTH1/CASP1/UBE2D1/ITPR1/CXCL8/PIK3R3/RIPK2/SKP1/ACTR3B/MAPK13/PTK2/PRKCE/MYL12B/CYTH3/PIK3R2/CD44/ARPC3/CAPNS1/RPS27A/SQSTM1/CAST/MYL9/AKT2/ARHGEF2	60
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/1364	100/8135	0.001523	0.007436	0.00481	PLCG2/PLCB1/AGTR1/SMAD3/MAPK3/FOXO1/VEGFA/PRKCB/ICAM1/PLCE1/STAT1/SELE/IL6/PLCD1/EDN1/PIM1/JAK2/TGFB2/KRAS/CDC42/MAPK10/CXCL8/PIK3R3/MAPK13/PRKCE/PIK3R2/NRAS/AKT2/CCND1	29
KEGG	hsa04722	Neurotrophin signaling pathway	33/1364	119/8135	0.001724	0.008295	0.005365	PLCG2/NFKBIA/MAPK3/SH2B2/MAGED1/NTRK2/ARHGDIB/MAP3K5/NFKBIE/RPS6KA1/KIDINS220/GSK3B/RAP1B/BAD/SORT1/IRAK4/KRAS/IRAK3/CDC42/MAPK10/ZNF274/SHC1/MAP2K1/PTPN11/MAPK7/PIK3R3/RIPK2/MAPK13/NTF3/PIK3R2/NRAS/MAPKAPK2/AKT2	33
KEGG	hsa04672	Intestinal immune network for IgA production	17/1364	49/8135	0.001766	0.008376	0.005418	TNFRSF17/IL15RA/HLA-DOB/CXCL12/CXCR4/IL15/CD40/HLA-DMB/ITGA4/IL6/ITGB7/HLA-DMA/CD40LG/HLA-DPA1/HLA-DRB4/HLA-DPB1/CD86	17
KEGG	hsa04916	Melanogenesis	29/1364	101/8135	0.001802	0.008426	0.00545	TCF7L2/PLCB1/TCF7L1/FZD4/KIT/WNT5B/MAPK3/PRKCB/FZD2/FZD7/KITLG/FZD6/ADCY8/GSK3B/EDN1/LEF1/WNT5A/KRAS/TCF7/MAP2K1/ADCY7/WNT11/ADCY6/WNT10B/CREB3L2/CREB3/MITF/NRAS/GNAS	29
KEGG	hsa04144	Endocytosis	60/1364	251/8135	0.002048	0.009445	0.006109	IL2RG/TFRC/RAB11FIP1/CCR5/ACTR3/ASAP2/IL2RB/SMAD3/PLD1/ARPC2/SNX1/ASAP3/WIPF1/CXCR4/ARPC5L/GRK5/ARRB1/ARPC1A/SH3GL1/ACAP1/HLA-A/HLA-E/HLA-F/CBLB/VPS28/EHD3/SMURF2/CAPZA1/HLA-C/PML/EHD1/IQSEC1/BIN1/VPS37C/IL2RA/SNX5/RAB22A/ACAP2/CDC42/EGFR/HLA-B/PSD4/CYTH1/AP2M1/EPN3/CHMP7/ACTR3B/KIF5C/HLA-G/PRKCI/WWP1/PARD3/HSPA6/CYTH3/CAV1/GRK6/ARPC3/DNM1/ARFGAP2/RAB8A	60
KEGG	hsa05142	Chagas disease	29/1364	102/8135	0.002124	0.009658	0.006247	PLCB1/CCL5/CD3D/NFKBIA/MYD88/CD3E/MAPK3/TLR2/CD247/CHUK/PPP2CA/IL6/GNA11/CD3G/PPP2R1A/IRAK4/TGFB2/MAPK10/TICAM1/CXCL8/PIK3R3/GNAL/MAPK13/FAS/IFNG/PPP2R1B/PIK3R2/AKT2/GNAS	29
KEGG	hsa04919	Thyroid hormone signaling pathway	33/1364	121/8135	0.002323	0.01042	0.006741	PLCG2/PLCB1/BMP4/MAPK3/FOXO1/DIO3/PRKCB/PLCE1/STAT1/GSK3B/PLCD1/ITGAV/BAD/THRB/ATP2A3/KRAS/DIO2/MAP2K1/RXRA/HDAC1/SLC9A1/PIK3R3/CASP9/NOTCH1/ITGB3/HIF1A/PIK3R2/NRAS/TSC2/AKT2/RHEB/NCOA1/CCND1	33
KEGG	hsa04934	Cushing syndrome	40/1364	155/8135	0.002619	0.01159	0.007499	TCF7L2/PLCB1/TCF7L1/FZD4/AGTR1/WNT5B/MAPK3/PBX1/FZD2/CDKN2C/FZD7/CCNE1/FZD6/ADCY8/GSK3B/RAP1B/GNA11/LEF1/WNT5A/NR4A1/ARNT/EGFR/TCF7/MAP2K1/ADCY7/WNT11/PDE8A/ITPR1/ADCY6/RBBP5/CACNA1D/WNT10B/E2F3/CREB3L2/CREB3/KCNK3/CACNA1F/CRHR1/CCND1/GNAS	40
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1364	20/8135	0.002928	0.01279	0.008274	CHST3/UST/XYLT1/CHST15/CHST11/DSE/XYLT2/CHST12/CSGALNACT1	9
KEGG	hsa04670	Leukocyte transendothelial migration	31/1364	114/8135	0.003257	0.01404	0.009083	PLCG2/RAC2/ITGAL/RHOH/NCF1/CXCL12/PRKCB/ITK/CXCR4/ICAM1/ARHGAP35/NCF4/ITGA4/JAM3/NCF2/RAP1B/PECAM1/VAV2/MYL12A/CDC42/PTPN11/PIK3R3/ITGB2/CLDN11/CDH5/MAPK13/PTK2/MYL12B/CD99/PIK3R2/MYL9	31
KEGG	hsa04072	Phospholipase D signaling pathway	38/1364	148/8135	0.00363	0.01545	0.009993	PLCG2/SYK/PLCB1/AGTR1/KIT/MAPK3/PLD1/AGPAT5/RALA/MS4A2/KITLG/PDGFD/F2R/LPAR1/ADCY8/KRAS/GAB2/SHC1/EGFR/MAP2K1/CYTH1/AGPAT1/TSC1/ADCY7/PTPN11/CXCL8/PIK3R3/ADCY6/RALGDS/PLA2G4C/CYTH3/PIK3R2/NRAS/TSC2/DNM1/AKT2/RHEB/GNAS	38
KEGG	hsa05215	Prostate cancer	27/1364	97/8135	0.004105	0.01725	0.01116	TCF7L2/TCF7L1/NFKBIA/MAPK3/FOXO1/CHUK/CCNE1/PDGFD/ERBB2/AR/GSK3B/BAD/LEF1/KRAS/EGFR/TCF7/MAP2K1/PIK3R3/CASP9/E2F3/CREB3L2/CREB3/PIK3R2/IL1R2/NRAS/AKT2/CCND1	27
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	23/1364	79/8135	0.004248	0.01763	0.0114	PLCG2/MAPK3/VEGFA/PRKCB/AXL/PDGFD/ERBB2/IL6R/GSK3B/IL6/BAD/JAK2/KRAS/FGF2/SHC1/EGFR/MAP2K1/MET/PIK3R3/HGF/PIK3R2/NRAS/AKT2	23
KEGG	hsa05219	Bladder cancer	14/1364	41/8135	0.005159	0.02114	0.01368	HBEGF/MAPK3/VEGFA/ERBB2/KRAS/MMP1/EGFR/MAP2K1/DAPK1/CXCL8/E2F3/THBS1/NRAS/CCND1	14
KEGG	hsa04910	Insulin signaling pathway	35/1364	137/8135	0.005567	0.02254	0.01458	PTPRF/MAPK3/FOXO1/SH2B2/PPP1R3C/SORBS1/LIPE/SOCS2/PCK1/ACACB/CBLB/GSK3B/SOCS1/BAD/INPP5A/KRAS/GYS1/PYGB/MAPK10/SHC1/MAP2K1/TSC1/PPP1CC/PCK2/INPPL1/SREBF1/PIK3R3/EXOC7/PRKCI/RHOQ/PIK3R2/NRAS/TSC2/AKT2/RHEB	35
KEGG	hsa05210	Colorectal cancer	24/1364	86/8135	0.006361	0.02544	0.01646	TCF7L2/RAC2/TCF7L1/SMAD3/MAPK3/RALA/CYCS/GSK3B/BAD/LEF1/TGFB2/KRAS/MAPK10/EGFR/TCF7/MAP2K1/PIK3R3/CASP9/RALGDS/PIK3R2/NRAS/AKT2/CCND1/EREG	24
KEGG	hsa04935	Growth hormone synthesis, secretion and action	31/1364	119/8135	0.006486	0.02564	0.01658	PLCG2/PLCB1/GHR/MAPK3/PRKCB/SOCS2/STAT1/ADCY8/GSK3B/SOCS1/GNA11/JAK2/KRAS/MAPK10/SHC1/MAP2K1/ADCY7/ITPR1/PIK3R3/ADCY6/CACNA1D/MAPK13/CREB3L2/PTK2/CREB3/PIK3R2/NRAS/CACNA1F/AKT2/MAP2K6/GNAS	31
KEGG	hsa00562	Inositol phosphate metabolism	21/1364	73/8135	0.007127	0.02784	0.018	PLCG2/PLCB1/ISYNA1/PIP4K2B/PLCE1/TPI1/PLCD1/INPP5A/INPP5K/IMPA1/MTMR6/INPP5D/ITPKB/INPPL1/MTMR14/ALDH6A1/INPP4A/PI4KB/PI4KA/MTM1/PIK3C2A	21
KEGG	hsa05222	Small cell lung cancer	25/1364	92/8135	0.007821	0.03019	0.01953	NFKBIA/TRAF3/CKS2/LAMB2/TRAF1/BIRC3/CHUK/CCNE1/CYCS/LAMC3/ITGAV/CKS1B/RXRA/LAMB3/PIK3R3/CASP9/LAMA4/E2F3/PTK2/TRAF4/LAMA2/ITGA3/PIK3R2/AKT2/CCND1	25
KEGG	hsa05146	Amoebiasis	27/1364	102/8135	0.008504	0.03245	0.02099	PLCB1/HSPB1/TLR2/PRKCB/LAMB2/CD14/LAMC3/CXCL1/IL6/GNA11/CXCL3/TGFB2/CXCL2/LAMB3/CTSG/CXCL8/PIK3R3/ITGB2/SERPINB9/LAMA4/GNAL/PTK2/LAMA2/IFNG/PIK3R2/IL1R2/GNAS	27
KEGG	hsa03320	PPAR signaling pathway	21/1364	75/8135	0.009895	0.0372	0.02406	FABP4/LPL/PPARG/PLIN1/ACSL5/ACOX2/SORBS1/ME3/ADIPOQ/GK/PCK1/SCD/MMP1/RXRA/PCK2/PLIN2/APOA2/PPARD/FABP1/ACSBG2/OLR1	21
KEGG	hsa05130	Pathogenic Escherichia coli infection	46/1364	197/8135	0.01003	0.0372	0.02406	NFKBIA/ACTR3/MYD88/TUBA4A/MAPK3/MYO1F/SEC24A/CYFIP2/ARPC2/TNFSF10/WIPF1/ARPC5L/HCLS1/WASF3/NAIP/CHUK/ARPC1A/CYCS/F2R/FCGR2A/LPAR1/IL6/MYH10/IRAK4/PTPN6/CDC42/MYO1B/MAPK10/TUBB6/CYTH1/MYH11/CASP1/PTPN11/NCKAP1L/CXCL8/CLDN11/CASP9/NCL/ACTR3B/MAPK13/FAS/CYTH3/ARPC3/PAK2/ABI1/ARHGEF2	46
KEGG	hsa05224	Breast cancer	36/1364	147/8135	0.01008	0.0372	0.02406	TCF7L2/TCF7L1/FZD4/KIT/WNT5B/MAPK3/FZD2/FRAT2/FZD7/FZD6/ERBB2/FGF7/GSK3B/LRP5/LEF1/HEY1/WNT5A/KRAS/FGF2/SHC1/EGFR/TCF7/MAP2K1/NFKB2/WNT11/PIK3R3/NOTCH1/HES1/WNT10B/E2F3/HEY2/PIK3R2/NRAS/AKT2/NCOA1/CCND1	36
KEGG	hsa04657	IL-17 signaling pathway	25/1364	94/8135	0.01041	0.03797	0.02456	TNFAIP3/CXCL10/NFKBIA/TRAF3/MAPK3/S100A9/CCL7/CHUK/CXCL6/CCL20/CXCL1/GSK3B/IL6/CXCL3/MMP1/CXCL2/MAPK10/IL17RC/S100A8/MAPK7/CXCL8/MAPK13/TRAF4/IFNG/CEBPB	25
KEGG	hsa04520	Adherens junction	20/1364	71/8135	0.01088	0.03926	0.02539	PTPRF/TCF7L2/RAC2/TCF7L1/SMAD3/MAPK3/WAS/SORBS1/NLK/PTPRM/WASF3/ERBB2/LEF1/CSNK2A2/PTPN6/CDC42/EGFR/TCF7/MET/PARD3	20
KEGG	hsa01232	Nucleotide metabolism	23/1364	85/8135	0.01103	0.03939	0.02548	ADA/RRM2/ENPP1/NME3/AMPD3/HPRT1/PNP/IMPDH2/AK1/TYMS/GUK1/GMPR/ENTPD4/CTPS1/TK2/NME4/DCK/HDDC2/TK1/ASMTL/IMPDH1/UPP1/GMPR2	23
KEGG	hsa04071	Sphingolipid signaling pathway	30/1364	119/8135	0.01185	0.04186	0.02708	RAC2/PLCB1/MAPK3/PLD1/MS4A2/PRKCB/S1PR1/ADORA3/MAP3K5/PPP2CA/SGPL1/PPP2R5D/CERS6/PPP2R1A/KRAS/MAPK10/GAB2/S1PR4/MAP2K1/CERS4/PIK3R3/NSMAF/ADORA1/S1PR5/MAPK13/PRKCE/PPP2R1B/PIK3R2/NRAS/AKT2	30
KEGG	hsa05213	Endometrial cancer	17/1364	58/8135	0.01208	0.0422	0.0273	TCF7L2/TCF7L1/MAPK3/ERBB2/GSK3B/BAD/LEF1/KRAS/EGFR/TCF7/MAP2K1/PIK3R3/CASP9/PIK3R2/NRAS/AKT2/CCND1	17
KEGG	hsa04621	NOD-like receptor signaling pathway	43/1364	184/8135	0.01232	0.04262	0.02757	GBP1/PLCB1/CCL5/TNFAIP3/NFKBIA/TRAF3/IFNAR2/CTSB/MYD88/AIM2/MAPK3/GBP2/NAMPT/GABARAPL1/TRIP6/NOD2/BIRC3/PSTPIP1/NAIP/CHUK/TRPV2/STAT1/OAS2/CXCL1/CARD8/IL6/IRF7/TANK/CXCL3/IRAK4/IRF9/CXCL2/MAPK10/CASP1/TICAM1/ITPR1/CXCL8/RIPK2/MAPK13/TXN/PANX1/TXN2/NLRX1	43
KEGG	hsa05223	Non-small cell lung cancer	20/1364	72/8135	0.01275	0.04365	0.02824	PLCG2/MAPK3/PRKCB/ERBB2/BAD/KRAS/EGFR/MAP2K1/RXRA/MET/PIK3R3/CASP9/HGF/KIF5C/E2F3/PIK3R2/NRAS/AKT2/CCND1/ALK	20
KEGG	hsa05143	African trypanosomiasis	12/1364	37/8135	0.01447	0.04903	0.03171	PLCB1/MYD88/PRKCB/IDO1/ICAM1/SELE/APOL1/IL6/HBB/LAMA4/FAS/IFNG	12
KEGG	hsa01524	Platinum drug resistance	20/1364	73/8135	0.01488	0.04989	0.03227	GSTA4/MAPK3/GSTT1/TOP2A/BIRC3/MAP3K5/CYCS/ERBB2/ERCC1/BAD/REV3L/SLC31A1/GSTM2/GSTM1/PIK3R3/CASP9/MGST3/FAS/PIK3R2/AKT2	20
KEGG	hsa05211	Renal cell carcinoma	19/1364	69/8135	0.01643	0.05436	0.03516	MAPK3/VEGFA/RAP1B/BAD/TGFB2/KRAS/ARNT/CDC42/MAP2K1/PTPN11/MET/PIK3R3/HGF/HIF1A/EGLN1/PIK3R2/NRAS/PAK2/AKT2	19
KEGG	hsa04390	Hippo signaling pathway	37/1364	157/8135	0.01693	0.05436	0.03516	TCF7L2/DLG5/TCF7L1/FZD4/BMP4/SMAD3/WNT5B/FZD2/BIRC3/FZD7/FZD6/ID1/PPP2CA/GSK3B/LEF1/PPP2R1A/WNT5A/TGFB2/LLGL2/BMPR1A/TCF7/PPP1CC/WNT11/ITGB2/BMP5/MPP5/WNT10B/PRKCI/PARD3/YAP1/PPP2R1B/CCND2/YWHAQ/CRB1/TEAD4/CCND3/CCND1	37
KEGG	hsa05160	Hepatitis C	37/1364	157/8135	0.01693	0.05436	0.03516	MX2/CXCL10/NFKBIA/TRAF3/IFNAR2/MAPK3/CHUK/CYCS/STAT1/OAS2/PPP2CA/GSK3B/IRF7/BAD/PPP2R1A/IRF9/KRAS/EIF3E/EGFR/MAP2K1/RXRA/TICAM1/CD81/PIK3R3/CLDN11/CASP9/E2F3/FAS/IFNG/PPP2R1B/DDX58/PIK3R2/YWHAQ/NRAS/MX1/AKT2/CCND1	37
KEGG	hsa04142	Lysosome	32/1364	132/8135	0.01697	0.05436	0.03516	GNPTAB/CTSB/CTSF/DMXL2/NPC1/LAMP3/CTSH/CTSL/CTSC/CTSA/AP1B1/HYAL1/PLA2G15/FUCA1/ABCA2/CTSO/ENTPD4/SORT1/PSAP/NAGA/NAGLU/AP1G2/CTSG/ACP2/CTSS/CTSW/CD63/LAMP2/LAMP1/LITAF/LIPA/GUSB	32
KEGG	hsa04730	Long-term depression	17/1364	60/8135	0.01703	0.05436	0.03516	PLCB1/MAPK3/PRKCB/GRIA2/LYN/PPP2CA/GNA11/PPP2R1A/KRAS/MAP2K1/ITPR1/PRKG1/PLA2G4C/PPP2R1B/NRAS/CRHR1/GNAS	17
KEGG	hsa04912	GnRH signaling pathway	24/1364	93/8135	0.01725	0.05455	0.03528	PLCB1/HBEGF/MAPK3/PLD1/PRKCB/ADCY8/GNA11/KRAS/CDC42/MAPK10/EGFR/MAP2K1/ADCY7/MAPK7/ITPR1/ADCY6/CACNA1D/MAPK13/PLA2G4C/NRAS/CACNA1F/MAP2K6/GNAS/MAP3K4	24
KEGG	hsa04530	Tight junction	39/1364	169/8135	0.02018	0.0632	0.04088	ACTR3/TUBA4A/WAS/ARPC2/ARPC5L/AMOTL2/HCLS1/ARPC1A/MAP3K5/ERBB2/PPP2CA/JAM3/PPP2R1A/ARHGEF18/MYH10/MYL12A/CDC42/MAPK10/LLGL2/RAP2C/MYH11/CLDN11/RDX/TIAM1/ACTR3B/MPP5/CACNA1D/PRKCI/PRKCE/PARD3/MYL12B/PPP2R1B/MYL6B/MPDZ/ARPC3/MYL9/CCND1/ARHGEF2/RAB8A	39
KEGG	hsa05226	Gastric cancer	35/1364	149/8135	0.02075	0.06421	0.04153	TCF7L2/TCF7L1/FZD4/SMAD3/WNT5B/MAPK3/FZD2/FRAT2/FZD7/CCNE1/FZD6/ERBB2/FGF7/GSK3B/LRP5/LEF1/WNT5A/TGFB2/KRAS/FGF2/SHC1/EGFR/TCF7/MAP2K1/RXRA/WNT11/MET/PIK3R3/HGF/WNT10B/E2F3/PIK3R2/NRAS/AKT2/CCND1	35
KEGG	hsa04611	Platelet activation	30/1364	124/8135	0.02089	0.06421	0.04153	PLCG2/SYK/PLCB1/RASGRP1/LCP2/MAPK3/ARHGAP35/LYN/F2R/FCGR2A/ADCY8/TLN2/RAP1B/RASGRP2/PTGS1/MYL12A/PPP1CC/ADCY7/ITPR1/PIK3R3/ADCY6/ITGB3/MAPK13/PRKCI/MYL12B/PRKG1/PLA2G4C/PIK3R2/AKT2/GNAS	30
KEGG	hsa04012	ErbB signaling pathway	22/1364	85/8135	0.02127	0.06479	0.0419	PLCG2/HBEGF/MAPK3/PRKCB/BTC/ERBB2/CBLB/GSK3B/BAD/ABL2/KRAS/MAPK10/SHC1/EGFR/MAP2K1/PIK3R3/PTK2/PIK3R2/NRAS/PAK2/AKT2/EREG	22
KEGG	hsa05220	Chronic myeloid leukemia	20/1364	76/8135	0.02295	0.06925	0.04479	NFKBIA/SMAD3/MAPK3/CHUK/BAD/TGFB2/KRAS/GAB2/SHC1/MAP2K1/HDAC1/BCR/PTPN11/PIK3R3/E2F3/PIK3R2/NRAS/AKT2/CCND1/MECOM	20
KEGG	hsa04152	AMPK signaling pathway	29/1364	120/8135	0.02319	0.06935	0.04485	PPARG/FOXO1/LIPE/ADIPOQ/PCK1/ACACB/PPP2CA/CAB39L/PPP2R5D/EEF2/PPP2R1A/SCD/GYS1/PFKFB3/TSC1/PCK2/SREBF1/PIK3R3/CAMKK2/CREB3L2/CREB3/CCNA2/PPP2R1B/PIK3R2/TSC2/AKT2/RHEB/CCND1/RAB8A	29
KEGG	hsa05150	Staphylococcus aureus infection	24/1364	96/8135	0.02503	0.07355	0.04757	FCGR2B/HLA-DOB/FPR1/ITGAL/CFD/CFH/C5AR1/FCGR3B/CFB/ICAM1/HLA-DMB/FCGR2A/CFI/HLA-DMA/FCGR2C/HLA-DPA1/C3AR1/SELPLG/HLA-DRB4/ITGB2/KRT32/FPR2/FCGR1A/HLA-DPB1	24
KEGG	hsa05414	Dilated cardiomyopathy	24/1364	96/8135	0.02503	0.07355	0.04757	SGCA/DAG1/SGCB/ITGA4/ADCY8/ITGAV/ITGB7/TNNI3/ATP2A3/TGFB2/ITGB5/ITGA7/LMNA/ADCY7/ADCY6/ITGB3/CACNA1D/LAMA2/ITGA3/CACNG3/SGCD/CACNB2/CACNA1F/GNAS	24
KEGG	hsa04140	Autophagy - animal	33/1364	141/8135	0.02545	0.07412	0.04794	CTSB/MAPK3/CTSL/GABARAPL1/PRKCQ/DDIT4/RRAGA/PPP2CA/WIPI1/RRAGB/BAD/TANK/KRAS/MAPK10/MAP2K1/DAPK1/TSC1/ITPR1/PIK3R3/CAMKK2/MTMR14/HIF1A/LAMP2/LAMP1/PIK3R2/NRAS/SQSTM1/TSC2/RAB33B/AKT2/RHEB/ULK2/RAB8A	33
KEGG	hsa04068	FoxO signaling pathway	31/1364	131/8135	0.02569	0.07416	0.04796	IL7R/SMAD3/MAPK3/FOXO1/TNFSF10/GABARAPL1/NLK/S1PR1/CHUK/PCK1/IL6/CAT/PLK2/TGFB2/KRAS/CCNB2/MAPK10/S1PR4/EGFR/MAP2K1/PCK2/PIK3R3/MAPK13/CCND2/PIK3R2/NRAS/CCNG2/SGK2/CCNB1/AKT2/CCND1	31
KEGG	hsa04310	Wnt signaling pathway	38/1364	167/8135	0.02665	0.07629	0.04934	TCF7L2/SFRP1/RAC2/PLCB1/TCF7L1/FZD4/SMAD3/WNT5B/PRKCB/NLK/FZD2/FRAT2/FZD7/FZD6/GSK3B/TBL1XR1/LRP5/LEF1/CSNK2A2/CBY1/WNT5A/MAPK10/PPP3CA/TCF7/GPC4/WIF1/RYK/WNT11/SKP1/SENP2/DAAM2/PPARD/WNT10B/VANGL1/CCND2/TLE3/CCND3/CCND1	38
KEGG	hsa04146	Peroxisome	21/1364	82/8135	0.02691	0.07637	0.0494	ACSL5/ACOX2/PEX5/EPHX2/PMVK/IDH2/CAT/PHYH/DDO/ECH1/GSTK1/PEX6/PEX19/SOD1/FAR2/HMGCL/PAOX/PXMP2/PEX11A/PEX10/PEX7	21
KEGG	hsa04115	p53 signaling pathway	19/1364	73/8135	0.02922	0.0822	0.05317	RRM2/CCNE1/CYCS/CCNB2/CCNG1/ATR/CD82/CASP9/CHEK2/CDK1/FAS/CCND2/THBS1/CCNG2/TSC2/CCND3/STEAP3/CCNB1/CCND1	19
KEGG	hsa04540	Gap junction	22/1364	88/8135	0.03098	0.08588	0.05555	PLCB1/TUBA4A/MAPK3/PRKCB/PDGFD/LPAR1/ADCY8/GNA11/KRAS/HTR2A/EGFR/MAP2K1/TUBB6/ADCY7/MAPK7/ITPR1/ADCY6/HTR2B/CDK1/PRKG1/NRAS/GNAS	22
KEGG	hsa04929	GnRH secretion	17/1364	64/8135	0.03148	0.08588	0.05555	PLCB1/MAPK3/PRKCB/TRPC1/ARRB1/GNA11/KRAS/GPER1/MAP2K1/ITPR1/PIK3R3/CACNA1D/TRPC4/PIK3R2/NRAS/CACNA1F/AKT2	17
KEGG	hsa01522	Endocrine resistance	24/1364	98/8135	0.03156	0.08588	0.05555	HBEGF/MAPK3/CDKN2C/ERBB2/ADCY8/BAD/KRAS/GPER1/MAPK10/SHC1/EGFR/MAP2K1/ADCY7/PIK3R3/ADCY6/NOTCH1/MAPK13/E2F3/PTK2/PIK3R2/NRAS/AKT2/CCND1/GNAS	24
KEGG	hsa05231	Choline metabolism in cancer	24/1364	98/8135	0.03156	0.08588	0.05555	RAC2/MAPK3/WAS/PLD1/PRKCB/LYPLA1/WASF3/PDGFD/CHPT1/CHKA/KRAS/MAPK10/EGFR/MAP2K1/TSC1/PIK3R3/HIF1A/RALGDS/PLA2G4C/PIK3R2/NRAS/TSC2/AKT2/RHEB	24
KEGG	hsa05216	Thyroid cancer	11/1364	37/8135	0.03565	0.09622	0.06224	TCF7L2/TCF7L1/PPARG/MAPK3/LEF1/KRAS/TCF7/MAP2K1/RXRA/NRAS/CCND1	11
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	48/1364	223/8135	0.03608	0.0966	0.06248	NFKBIA/NQO1/GSTA4/NCF1/MAPK3/VEGFA/GSTT1/PLD1/CHUK/EPHX2/MAP3K5/COX7A1/EPHX1/NCF2/PRKD2/CAT/BAD/ABL2/KEAP1/AKR1C1/KRAS/ARNT/MAPK10/NDUFV1/EGFR/MAP2K1/GSTM2/SLC25A6/SOD1/PTPN11/MET/GSTM1/PIK3R3/COX5A/COX6C/NDUFS4/NDUFA10/NDUFA13/HGF/HIF1A/MAPK13/NDUFB7/PTK2/MGST3/PIK3R2/NRAS/AKT2/NDUFS7	48
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/1364	70/8135	0.03715	0.09867	0.06382	PLCG2/CCL5/HBEGF/NFKBIA/CHUK/LYN/JAM3/CXCL1/CXCL3/CSK/CXCL2/CDC42/MAPK10/EGFR/PTPN11/MET/CXCL8/MAPK13	18
KEGG	hsa04610	Complement and coagulation cascades	21/1364	85/8135	0.03884	0.1014	0.06561	SERPINA1/PROS1/F13A1/C7/CLU/CFD/CFH/C6/C5AR1/CR1/CFB/F2R/CFI/ITGAX/TFPI/SERPINA5/F8/CFHR2/C3AR1/ITGB2/C4BPB	21
KEGG	hsa04923	Regulation of lipolysis in adipocytes	15/1364	56/8135	0.03896	0.1014	0.06561	FABP4/NPY1R/PLIN1/LIPE/ADCY8/PTGS1/PNPLA2/ADCY7/PIK3R3/ADCY6/ADORA1/PRKG1/PIK3R2/AKT2/GNAS	15
KEGG	hsa05410	Hypertrophic cardiomyopathy	22/1364	90/8135	0.03911	0.1014	0.06561	SGCA/DAG1/SGCB/ITGA4/IL6/ITGAV/ITGB7/EDN1/TNNI3/ATP2A3/TGFB2/ITGB5/ITGA7/LMNA/ITGB3/CACNA1D/LAMA2/ITGA3/CACNG3/SGCD/CACNB2/CACNA1F	22
KEGG	hsa00230	Purine metabolism	29/1364	128/8135	0.05057	0.1301	0.08417	PDE1A/ADA/RRM2/ENPP1/NME3/AMPD3/NPR2/HPRT1/PNP/IMPDH2/AK1/ADCY8/GUK1/PAPSS2/GMPR/ENTPD4/NME4/PDE1B/DCK/HDDC2/PAPSS1/ENPP4/ADCY7/PDE8A/ADCY6/PDE5A/IMPDH1/GART/GMPR2	29
KEGG	hsa04066	HIF-1 signaling pathway	25/1364	109/8135	0.0582	0.1486	0.09614	TFRC/PLCG2/MAPK3/VEGFA/PRKCB/ANGPT1/ANGPT2/ERBB2/IL6R/IL6/EDN1/TF/PFKFB3/ARNT/EGFR/TEK/MAP2K1/PIK3R3/ALDOC/HIF1A/PDK1/IFNG/EGLN1/PIK3R2/AKT2	25
KEGG	hsa04920	Adipocytokine signaling pathway	17/1364	69/8135	0.06028	0.1528	0.09881	TNFRSF1B/NFKBIA/ACSL5/ADIPOQ/PRKCQ/CHUK/PCK1/ACACB/NFKBIE/JAK2/MAPK10/RXRA/PCK2/PTPN11/CAMKK2/ACSBG2/AKT2	17
KEGG	hsa00410	beta-Alanine metabolism	9/1364	31/8135	0.06271	0.1565	0.1012	ALDH3A2/ALDH7A1/HIBCH/ECHS1/ALDH6A1/ALDH3B1/CNDP2/DPYS/AOC3	9
KEGG	hsa05310	Asthma	9/1364	31/8135	0.06271	0.1565	0.1012	HLA-DOB/MS4A2/CD40/HLA-DMB/HLA-DMA/CD40LG/HLA-DPA1/HLA-DRB4/HLA-DPB1	9
KEGG	hsa04979	Cholesterol metabolism	13/1364	50/8135	0.06461	0.1601	0.1035	LRP1/LPL/NPC1/APOE/LRPAP1/LIPC/SORT1/APOA2/SOAT1/APOC1/LCAT/LIPA/VAPA	13
KEGG	hsa04110	Cell cycle	28/1364	126/8135	0.06647	0.1635	0.1057	PTTG1/SMAD3/MCM5/CDC7/CDKN2C/CDC20/CCNE1/SMC1A/CDKN1C/DBF4/GSK3B/TGFB2/CCNB2/MCM7/HDAC1/ATR/SKP1/BUB1B/CHEK2/CDK1/E2F3/CCNA2/CCND2/ESPL1/YWHAQ/CCND3/CCNB1/CCND1	28
KEGG	hsa04927	Cortisol synthesis and secretion	16/1364	65/8135	0.06744	0.1641	0.1061	PLCB1/AGTR1/PBX1/ADCY8/GNA11/NR4A1/ADCY7/PDE8A/ITPR1/ADCY6/CACNA1D/CREB3L2/CREB3/KCNK3/CACNA1F/GNAS	16
KEGG	hsa05230	Central carbon metabolism in cancer	17/1364	70/8135	0.0677	0.1641	0.1061	SLC7A5/KIT/MAPK3/ERBB2/IDH2/KRAS/SCO2/EGFR/MAP2K1/SIRT3/MET/PIK3R3/HIF1A/PDK1/PIK3R2/NRAS/AKT2	17
KEGG	hsa00920	Sulfur metabolism	4/1364	10/8135	0.07092	0.1706	0.1104	SELENBP1/PAPSS2/PAPSS1/TST	4
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1364	143/8135	0.07364	0.1759	0.1138	FZD4/BMP4/SMAD3/WNT5B/MAPK3/ID3/FZD2/FZD7/FZD6/ID1/PCGF2/GSK3B/JAK2/ID4/WNT5A/KRAS/FGF2/BMPR1A/TCF7/MAP2K1/WNT11/PIK3R3/HOXA1/MAPK13/WNT10B/JARID2/MEIS1/PIK3R2/NRAS/LIFR/AKT2	31
KEGG	hsa04070	Phosphatidylinositol signaling system	22/1364	97/8135	0.07983	0.1893	0.1224	PLCG2/PLCB1/PRKCB/CDS2/PIP4K2B/PLCE1/PLCD1/INPP5A/IMPA1/MTMR6/INPP5D/ITPKB/INPPL1/ITPR1/PIK3R3/MTMR14/PIK3R2/INPP4A/PI4KB/PI4KA/MTM1/PIK3C2A	22
KEGG	hsa00380	Tryptophan metabolism	11/1364	42/8135	0.08129	0.1914	0.1238	ALDH3A2/ALDH7A1/IDO1/ACAT1/HADH/CAT/MAOA/ECHS1/KYNU/KMO/HAAO	11
KEGG	hsa00650	Butanoate metabolism	8/1364	28/8135	0.08352	0.1944	0.1257	BDH2/ACSM5/ACAT1/HADH/OXCT1/ECHS1/HMGCL/ALDH5A1	8
KEGG	hsa05218	Melanoma	17/1364	72/8135	0.08433	0.1944	0.1257	MAPK3/PDGFD/FGF7/BAD/KRAS/FGF2/EGFR/MAP2K1/MET/PIK3R3/HGF/E2F3/MITF/PIK3R2/NRAS/AKT2/CCND1	17
KEGG	hsa04931	Insulin resistance	24/1364	108/8135	0.08441	0.1944	0.1257	PTPRF/NFKBIA/FOXO1/PPP1R3C/PRKCB/PRKCQ/PCK1/ACACB/RPS6KA1/GSK3B/IL6/GYS1/PYGB/MAPK10/PPP1CC/PCK2/PTPN11/SREBF1/PIK3R3/CREB3L2/PRKCE/CREB3/PIK3R2/AKT2	24
KEGG	hsa04213	Longevity regulating pathway - multiple species	15/1364	62/8135	0.08491	0.1944	0.1257	FOXO1/CRYAB/ADCY8/CAT/KRAS/EIF4EBP2/HDAC1/ADCY7/SOD1/PIK3R3/ADCY6/HSPA6/PIK3R2/NRAS/AKT2	15
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	22/1364	98/8135	0.08737	0.1987	0.1285	PLCG2/PLCB1/PRKCB/PRKCQ/TRPV2/PRKCH/ADCY8/PTGER4/MAPK10/HTR2A/PPP1CC/ADCY7/ITPR1/PIK3R3/ADCY6/HTR2B/MAPK13/PRKCE/PLA2G4C/PIK3R2/MAP2K6/GNAS	22
KEGG	hsa04512	ECM-receptor interaction	20/1364	88/8135	0.09013	0.2036	0.1317	SDC1/SV2B/DAG1/THBS4/LAMB2/LAMC3/ITGA4/ITGAV/ITGB7/COMP/ITGB5/ITGA7/LAMB3/LAMA4/ITGB3/LAMA2/ITGA3/THBS1/CD44/DSPP	20
KEGG	hsa00071	Fatty acid degradation	11/1364	43/8135	0.09345	0.2081	0.1346	ALDH3A2/ALDH7A1/ACSL5/ACADVL/ECI1/ACAT1/HADH/ECHS1/ADH5/ADH1C/ACSBG2	11
KEGG	hsa00280	Valine, leucine and isoleucine degradation	12/1364	48/8135	0.09465	0.2081	0.1346	ALDH3A2/ALDH7A1/ACAT1/HIBCH/BCKDHB/HADH/OXCT1/ECHS1/MCCC1/HMGCL/BCAT1/ALDH6A1	12
KEGG	hsa04623	Cytosolic DNA-sensing pathway	15/1364	63/8135	0.09498	0.2081	0.1346	CCL5/CXCL10/NFKBIA/AIM2/CHUK/POLR2E/IL6/IRF7/CCL4/POLR1D/CASP1/POLR2L/DDX58/POLR2F/POLR3F	15
KEGG	hsa00240	Pyrimidine metabolism	14/1364	58/8135	0.09529	0.2081	0.1346	RRM2/ENPP1/NME3/TYMS/ENTPD4/CTPS1/TK2/NME4/DCK/HDDC2/TK1/DPYS/ASMTL/UPP1	14
KEGG	hsa00480	Glutathione metabolism	14/1364	58/8135	0.09529	0.2081	0.1346	LAP3/GPX4/HPGDS/GPX3/RRM2/GSTA4/GSTT1/IDH2/LANCL1/PRDX6/GSTK1/GSTM2/GSTM1/MGST3	14
KEGG	hsa04114	Oocyte meiosis	28/1364	131/8135	0.09847	0.2137	0.1382	PTTG1/MAPK3/CDC20/CCNE1/PPP2CA/SMC1A/AR/RPS6KA1/ADCY8/PPP2R5D/PPP2R1A/CCNB2/CPEB1/PPP3CA/MAP2K1/PPP1CC/ADCY7/FBXO5/ITPR1/ADCY6/SKP1/CDK1/MAPK13/SLK/PPP2R1B/ESPL1/YWHAQ/CCNB1	28
KEGG	hsa04924	Renin secretion	16/1364	69/8135	0.1047	0.2257	0.146	PDE1A/PLCB1/AGTR1/CTSB/EDN1/PTGER4/KCNJ2/PDE1B/PPP3CA/ITPR1/ADCY6/ADORA1/CACNA1D/AQP1/CACNA1F/GNAS	16
KEGG	hsa05203	Viral carcinogenesis	41/1364	204/8135	0.1175	0.2516	0.1627	SYK/NFKBIA/CCR5/TRAF3/MAPK3/TRAF1/GSN/EGR3/CDC20/CCNE1/LYN/HLA-A/HLA-E/HLA-F/IRF7/HLA-C/BAD/DDB1/IRF9/REL/KRAS/CDC42/HLA-B/NFKB2/HDAC1/PIK3R3/EGR2/HDAC4/CDK1/HLA-G/CREB3L2/SND1/CREB3/CCNA2/CCND2/PIK3R2/YWHAQ/NRAS/MAPKAPK2/CCND3/CCND1	41
KEGG	hsa04270	Vascular smooth muscle contraction	28/1364	134/8135	0.1218	0.2593	0.1677	PLCB1/PLA2G2D/AGTR1/CALD1/MAPK3/NPR2/PRKCB/PRKCQ/PRKCH/ADCY8/EDN1/GNA11/MYH10/MAP2K1/MYH11/PPP1CC/ADCY7/ITPR1/ADCY6/CACNA1D/PRKCE/PLA2G2F/PRKG1/PLA2G4C/MYL6B/CACNA1F/MYL9/GNAS	28
KEGG	hsa04150	mTOR signaling pathway	32/1364	156/8135	0.125	0.2628	0.17	FZD4/SLC7A5/WNT5B/MAPK3/PRKCB/FZD2/DDIT4/FZD7/CHUK/RRAGA/FZD6/CAB39L/RPS6KA1/GSK3B/RRAGB/LRP5/WNT5A/KRAS/MAP2K1/TSC1/WNT11/PIK3R3/WNT10B/SLC3A2/NPRL2/PIK3R2/GRB10/NRAS/TSC2/AKT2/RHEB/ULK2	32
KEGG	hsa04725	Cholinergic synapse	24/1364	113/8135	0.1256	0.2628	0.17	PLCB1/GNG12/MAPK3/PRKCB/GNG10/ADCY8/GNA11/JAK2/KCNJ2/KRAS/MAP2K1/KCNQ3/ADCY7/ITPR1/PIK3R3/ADCY6/CACNA1D/CREB3L2/CREB3/PIK3R2/NRAS/CACNA1F/ACHE/AKT2	24
KEGG	hsa00770	Pantothenate and CoA biosynthesis	6/1364	21/8135	0.1259	0.2628	0.17	ALDH3A2/ENPP1/BCAT1/DPYS/VNN2/VNN1	6
KEGG	hsa05100	Bacterial invasion of epithelial cells	17/1364	77/8135	0.1366	0.2819	0.1823	ACTR3/ARPC2/ARPC5L/HCLS1/ARPC1A/DOCK1/CDC42/SHC1/MET/PIK3R3/ACTR3B/PTK2/CAV1/PIK3R2/RHOG/ARPC3/DNM1	17
KEGG	hsa04216	Ferroptosis	10/1364	41/8135	0.1367	0.2819	0.1823	TFRC/GPX4/SLC39A8/ACSL5/CP/TF/FTL/SLC3A2/STEAP3/SLC39A14	10
KEGG	hsa00450	Selenocompound metabolism	5/1364	17/8135	0.1421	0.2913	0.1884	PAPSS2/SEPHS1/TXNRD2/PAPSS1/SEPHS2	5
KEGG	hsa00340	Histidine metabolism	6/1364	22/8135	0.1499	0.3052	0.1974	ALDH3A2/ALDH7A1/MAOA/HDC/ALDH3B1/CNDP2	6
KEGG	hsa00620	Pyruvate metabolism	11/1364	47/8135	0.1523	0.3083	0.1994	ALDH3A2/PC/ALDH7A1/ME3/ACAT1/PCK1/ACACB/PCK2/ADH5/ADH1C/ACYP1	11
KEGG	hsa04211	Longevity regulating pathway	19/1364	89/8135	0.1536	0.3092	0.2	PPARG/FOXO1/ADIPOQ/ADCY8/CAT/KRAS/TSC1/ADCY7/PIK3R3/ADCY6/CAMKK2/CREB3L2/CREB3/PIK3R2/NRAS/KL/TSC2/AKT2/RHEB	19
KEGG	hsa05217	Basal cell carcinoma	14/1364	63/8135	0.1595	0.3189	0.2063	TCF7L2/TCF7L1/FZD4/BMP4/WNT5B/FZD2/FZD7/FZD6/GSK3B/LEF1/WNT5A/TCF7/WNT11/WNT10B	14
KEGG	hsa00983	Drug metabolism - other enzymes	17/1364	80/8135	0.1752	0.3483	0.2253	RRM2/GSTA4/NME3/GSTT1/HPRT1/IMPDH2/TK2/NME4/GSTM2/GSTM1/TK1/DPYS/MGST3/IMPDH1/UPP1/GUSB/UGT2B4	17
KEGG	hsa05133	Pertussis	16/1364	76/8135	0.1948	0.3849	0.2489	MYD88/IRF1/MAPK3/CD14/CXCL6/IRF8/LY96/IL6/IRAK4/MAPK10/CASP1/TICAM1/CXCL8/ITGB2/MAPK13/C4BPB	16
KEGG	hsa03020	RNA polymerase	8/1364	34/8135	0.1991	0.3911	0.2529	POLR2E/POLR1D/POLR2L/POLR1E/POLR2I/POLR2F/POLR2D/POLR3F	8
KEGG	hsa04728	Dopaminergic synapse	26/1364	132/8135	0.2117	0.4114	0.2661	PLCB1/GNG12/PRKCB/SLC18A2/GRIA2/GNG10/ARRB1/PPP2CA/GSK3B/PPP2R5D/MAOA/PPP2R1A/DRD4/MAPK10/PPP3CA/PPP1CC/ITPR1/GNAL/KIF5C/CACNA1D/MAPK13/CREB3L2/CREB3/PPP2R1B/AKT2/GNAS	26
KEGG	hsa02010	ABC transporters	10/1364	45/8135	0.2119	0.4114	0.2661	TAP1/ABCC4/ABCA8/ABCG1/ABCA2/ABCA3/ABCA5/ABCC3/ABCA6/ABCC10	10
KEGG	hsa00260	Glycine, serine and threonine metabolism	9/1364	40/8135	0.2174	0.4196	0.2714	ALDH7A1/MAOA/SDS/CBS/BHMT/AOC3/SARDH/ALAS1/GAMT	9
KEGG	hsa04350	TGF-beta signaling pathway	19/1364	94/8135	0.2196	0.4215	0.2726	BMP4/NEO1/SMAD3/MAPK3/NBL1/ID3/ID1/PPP2CA/SMURF2/PPP2R1A/ID4/TGFB2/BMPR1A/TGIF2/BMP5/SKP1/IFNG/PPP2R1B/THBS1	19
KEGG	hsa04720	Long-term potentiation	14/1364	67/8135	0.2235	0.4265	0.2759	PLCB1/MAPK3/PPP1R1A/PRKCB/GRIA2/RPS6KA1/ADCY8/RAP1B/KRAS/PPP3CA/MAP2K1/PPP1CC/ITPR1/NRAS	14
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	16/1364	78/8135	0.2258	0.4273	0.2763	HPGDS/AKR7A2/GSTA4/GSTT1/AKR7A3/EPHX1/AKR1C1/GSTK1/GSTM2/GSTM1/ALDH3B1/ADH5/ADH1C/MGST3/CBR3/UGT2B4	16
KEGG	hsa00020	Citrate cycle (TCA cycle)	7/1364	30/8135	0.2278	0.4273	0.2763	PC/PCK1/IDH2/IDH3A/PCK2/OGDHL/IDH3B	7
KEGG	hsa01523	Antifolate resistance	7/1364	30/8135	0.2278	0.4273	0.2763	ABCC4/GGH/CHUK/TYMS/IL6/ABCC3/GART	7
KEGG	hsa04926	Relaxin signaling pathway	25/1364	129/8135	0.2434	0.4539	0.2936	PLCB1/GNG12/NFKBIA/MAPK3/VEGFA/GNG10/ARRB1/ADCY8/EDN1/KRAS/MMP1/MAPK10/SHC1/EGFR/MAP2K1/ADCY7/PIK3R3/ADCY6/MAPK13/CREB3L2/CREB3/PIK3R2/NRAS/AKT2/GNAS	25
KEGG	hsa00350	Tyrosine metabolism	8/1364	36/8135	0.2474	0.4589	0.2968	FAH/HPD/MAOA/PNMT/ALDH3B1/ADH5/ADH1C/AOC3	8
KEGG	hsa00790	Folate biosynthesis	6/1364	26/8135	0.2622	0.4813	0.3113	GCH1/ALPL/GGH/AKR1B10/PCBD1/AKR1B1	6
KEGG	hsa01240	Biosynthesis of cofactors	29/1364	153/8135	0.2624	0.4813	0.3113	GCH1/ALDH3A2/MTHFD2/NQO1/ALPL/NME3/GGH/PPOX/IDO1/HPD/AK1/RFK/CTPS1/NME4/VKORC1/UROD/RGN/ALAD/KYNU/PMM1/DHRS3/MAT2A/BCAT1/KMO/UGP2/GUSB/ALAS1/UGT2B4/HAAO	29
KEGG	hsa00360	Phenylalanine metabolism	4/1364	16/8135	0.2746	0.5	0.3234	HPD/MAOA/ALDH3B1/AOC3	4
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1364	11/8135	0.2764	0.5	0.3234	NQO1/HPD/VKORC1	3
KEGG	hsa04622	RIG-I-like receptor signaling pathway	14/1364	70/8135	0.2776	0.5	0.3234	CXCL10/NFKBIA/TRAF3/CHUK/IRF7/TANK/MAPK10/IFIH1/CXCL8/PIN1/CASP10/MAPK13/DDX58/NLRX1	14
KEGG	hsa00564	Glycerophospholipid metabolism	19/1364	98/8135	0.2801	0.5	0.3234	PLA2G2D/PLD1/AGPAT5/LYPLA1/CDS2/PTDSS1/PLA2G15/CHPT1/PEMT/CHKA/GPD1/AGPAT1/PLA1A/LCAT/PLA2G2F/PNPLA6/PLA2G4C/MBOAT2/ACHE	19
KEGG	hsa04925	Aldosterone synthesis and secretion	19/1364	98/8135	0.2801	0.5	0.3234	PLCB1/AGTR1/PRKCB/LIPE/ADCY8/PRKD2/GNA11/ATP2B1/NR4A1/ADCY7/ITPR1/ADCY6/CACNA1D/CREB3L2/PRKCE/CREB3/KCNK3/CACNA1F/GNAS	19
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	39/1364	212/8135	0.2865	0.5074	0.3282	GSTA4/MAPK3/VEGFA/GSTT1/PRKCB/ARRB1/EPHX2/EPHX1/AR/RPS6KA1/KPNA3/FGF7/ADCY8/BAD/JAK2/KRAS/ARNT/FGF2/KPNA2/EGFR/MAP2K1/GSTM2/RXRA/ADCY7/GSTM1/PIK3R3/ADCY6/CACNA1D/CREB3L2/CREB3/MGST3/PIK3R2/NRAS/CACNA1F/CCND3/AKT2/CCND1/GNAS/UGT2B4	39
KEGG	hsa04932	Non-alcoholic fatty liver disease	29/1364	155/8135	0.2873	0.5074	0.3282	XBP1/PPARG/CEBPA/ADIPOQ/MAP3K5/COX7A1/CYCS/IL6R/GSK3B/IL6/CDC42/MAPK10/NDUFV1/RXRA/SREBF1/CXCL8/PIK3R3/COX5A/MAP3K11/COX6C/NDUFS4/NDUFA10/NDUFA13/MAPK13/NDUFB7/FAS/PIK3R2/AKT2/NDUFS7	29
KEGG	hsa00982	Drug metabolism - cytochrome P450	14/1364	72/8135	0.3158	0.5518	0.3569	HPGDS/GSTA4/GSTT1/MAOA/GSTK1/GSTM2/GSTM1/ALDH3B1/ADH5/FMO2/ADH1C/MGST3/FMO1/UGT2B4	14
KEGG	hsa04137	Mitophagy - animal	14/1364	72/8135	0.3158	0.5518	0.3569	FIS1/GABARAPL1/CSNK2A2/KRAS/PINK1/MAPK10/NBR1/OPTN/HIF1A/BCL2L13/MITF/NRAS/RPS27A/SQSTM1	14
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	20/1364	106/8135	0.3177	0.5522	0.3572	PLCB1/HBEGF/MAPK3/PLD1/PRKCB/PTH1R/ARRB1/ADCY8/LRP5/GNA11/EGFR/MAP2K1/RXRA/ADCY7/ITPR1/ADCY6/CREB3L2/CREB3/KL/GNAS	20
KEGG	hsa00510	N-Glycan biosynthesis	10/1364	50/8135	0.3236	0.5596	0.3619	DPM3/FUT8/DPAGT1/B4GALT3/MGAT4C/MAN1B1/MAN2A1/ST6GAL1/MAN1C1/ALG6	10
KEGG	hsa03060	Protein export	5/1364	23/8135	0.3398	0.5796	0.3749	SPCS3/SRP19/SEC63/SEC11A/SPCS1	5
KEGG	hsa03430	Mismatch repair	5/1364	23/8135	0.3398	0.5796	0.3749	RPA1/RFC4/MLH3/POLD4/POLD2	5
KEGG	hsa00040	Pentose and glucuronate interconversions	7/1364	34/8135	0.3405	0.5796	0.3749	CRYL1/AKR1B10/AKR1B1/UGP2/GUSB/KL/UGT2B4	7
KEGG	hsa04914	Progesterone-mediated oocyte maturation	19/1364	102/8135	0.3456	0.5796	0.3749	STK10/MAPK3/RPS6KA1/ADCY8/KRAS/CCNB2/CPEB1/MAPK10/MAP2K1/ADCY7/PIK3R3/ADCY6/KIF22/CDK1/MAPK13/CCNA2/PIK3R2/CCNB1/AKT2	19
KEGG	hsa04972	Pancreatic secretion	19/1364	102/8135	0.3456	0.5796	0.3749	CD38/PLCB1/PLA2G2D/PRKCB/TRPC1/ADCY8/RAP1B/CPA3/ATP2B1/ATP2A3/SLC4A2/SLC9A1/ADCY7/ITPR1/ADCY6/PLA2G2F/CPB1/GNAS/RAB8A	19
KEGG	hsa00270	Cysteine and methionine metabolism	10/1364	51/8135	0.3474	0.5796	0.3749	BHMT2/DNMT1/AMD1/CDO1/SDS/MAT2A/TST/CBS/BCAT1/BHMT	10
KEGG	hsa00330	Arginine and proline metabolism	10/1364	51/8135	0.3474	0.5796	0.3749	LAP3/ALDH3A2/ALDH7A1/CKB/MAOA/AMD1/CNDP2/ALDH4A1/GAMT/ALDH18A1	10
KEGG	hsa04921	Oxytocin signaling pathway	28/1364	154/8135	0.3499	0.5809	0.3757	CD38/PLCB1/MAPK3/NPR2/PRKCB/ADCY8/EEF2/KCNJ2/KRAS/PPP3CA/EGFR/MAP2K1/PPP1CC/ADCY7/MAPK7/ITPR1/ADCY6/CAMKK2/CACNA1D/PLA2G4C/CACNG3/CACNB2/MYL6B/NRAS/CACNA1F/MYL9/CCND1/GNAS	28
KEGG	hsa05032	Morphine addiction	17/1364	91/8135	0.3531	0.5832	0.3772	PDE1A/GNG12/PRKCB/GNG10/GRK5/ARRB1/ADCY8/GABRB1/GABRA4/PDE1B/ADCY7/PDE8A/ADCY6/ADORA1/GRK6/GABRR1/GNAS	17
KEGG	hsa04392	Hippo signaling pathway - multiple species	6/1364	29/8135	0.357	0.5867	0.3795	RASSF4/RASSF2/DCHS1/FAT4/YAP1/TEAD4	6
KEGG	hsa04930	Type II diabetes mellitus	9/1364	46/8135	0.363	0.5937	0.384	MAPK3/ADIPOQ/SOCS2/SOCS1/MAPK10/PIK3R3/CACNA1D/PRKCE/PIK3R2	9
KEGG	hsa04613	Neutrophil extracellular trap formation	34/1364	190/8135	0.3665	0.5964	0.3858	PLCG2/RAC2/SYK/PLCB1/FPR1/ITGAL/NCF1/MAPK3/TLR2/C5AR1/PRKCB/CR1/FCGR3B/NCF4/FCGR2A/CLEC7A/NCF2/AQP9/MAP2K1/HDAC1/CASP1/SLC25A6/CLCN4/SELPLG/CTSG/PIK3R3/ITGB2/ITGB3/HDAC4/MAPK13/PIK3R2/FPR2/FCGR1A/AKT2	34
KEGG	hsa04726	Serotonergic synapse	21/1364	115/8135	0.3705	0.6	0.3881	PLCB1/GNG12/MAPK3/PRKCB/SLC18A2/TRPC1/GNG10/GABRB1/ALOX5/MAOA/PTGS1/KRAS/HTR2A/MAP2K1/ITPR1/HTR2B/CACNA1D/PLA2G4C/NRAS/CACNA1F/GNAS	21
KEGG	hsa00514	Other types of O-glycan biosynthesis	9/1364	47/8135	0.3887	0.6214	0.4019	GALNT10/GALNT6/GALNT11/B4GALT3/EOGT/LFNG/POFUT2/ST6GAL1/POFUT1	9
KEGG	hsa03420	Nucleotide excision repair	9/1364	47/8135	0.3887	0.6214	0.4019	RPA1/ERCC1/DDB1/RFC4/ERCC2/CETN2/POLD4/POLD2/CUL4B	9
KEGG	hsa00053	Ascorbate and aldarate metabolism	6/1364	30/8135	0.3893	0.6214	0.4019	ALDH3A2/ALDH7A1/RGN/GUSB/KL/UGT2B4	6
KEGG	hsa00531	Glycosaminoglycan degradation	4/1364	19/8135	0.3977	0.6287	0.4066	HYAL1/NAGLU/HPSE/GUSB	4
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1364	19/8135	0.3977	0.6287	0.4066	IDH2/IDH3A/BCAT1/IDH3B	4
KEGG	hsa03030	DNA replication	7/1364	36/8135	0.3996	0.6287	0.4066	MCM5/RPA1/RFC4/MCM7/FEN1/POLD4/POLD2	7
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	7/1364	37/8135	0.4291	0.671	0.434	MAPK3/PRKCB/NR3C2/KRAS/PIK3R3/HSD11B2/PIK3R2	7
KEGG	hsa04723	Retrograde endocannabinoid signaling	26/1364	148/8135	0.4305	0.671	0.434	PLCB1/GNG12/MAPK3/PRKCB/ABHD6/GRIA2/GNG10/ADCY8/GABRB1/GABRA4/MAPK10/NDUFV1/RIMS1/ADCY7/ITPR1/SLC17A6/ADCY6/NDUFS4/NDUFA10/NDUFA13/CACNA1D/MAPK13/NDUFB7/CACNA1F/GABRR1/NDUFS7	26
KEGG	hsa00860	Porphyrin metabolism	8/1364	43/8135	0.4351	0.6751	0.4366	CP/PPOX/UROD/ALAD/GUSB/ALAS1/BLVRA/UGT2B4	8
KEGG	hsa00565	Ether lipid metabolism	9/1364	49/8135	0.4401	0.6796	0.4395	PLA2G2D/PLD1/CHPT1/GDPD3/PLA2G7/PAFAH1B3/PAFAH1B2/PLA2G2F/PLA2G4C	9
KEGG	hsa00561	Glycerolipid metabolism	11/1364	61/8135	0.4479	0.6849	0.443	ALDH3A2/LPL/ALDH7A1/AGPAT5/GK/LIPC/AKR1B10/AGPAT1/PNPLA2/AKR1B1/MBOAT2	11
KEGG	hsa00590	Arachidonic acid metabolism	11/1364	61/8135	0.4479	0.6849	0.443	LTC4S/HPGDS/GPX3/PTGDS/PLA2G2D/EPHX2/ALOX5/PTGS1/PLA2G2F/PLA2G4C/CBR3	11
KEGG	hsa04022	cGMP-PKG signaling pathway	29/1364	167/8135	0.4497	0.6849	0.443	PLCB1/AGTR1/MAPK3/NPR2/GTF2IRD1/ADORA3/ADCY8/KCNJ8/GNA11/BAD/ATP2B1/ATP2A3/PPP3CA/MAP2K1/SLC25A6/PPP1CC/ADCY7/ITPR1/ADCY6/ADORA1/CACNA1D/PDE5A/CREB3L2/PRKCE/CREB3/PRKG1/CACNA1F/MYL9/AKT2	29
KEGG	hsa00640	Propanoate metabolism	6/1364	32/8135	0.4536	0.6876	0.4448	HIBCH/BCKDHB/ACSS3/ACACB/ECHS1/ALDH6A1	6
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	26/1364	150/8135	0.46	0.6912	0.447	PLCB1/AGTR1/MAPK3/PPP1R1A/PPP2CA/ADCY8/PPP2R5D/PPP2R1A/ATP2B1/TNNI3/ATP2A3/SLC9A1/PPP1CC/ADCY7/ADCY6/CACNA1D/MAPK13/CREB3L2/CREB3/PPP2R1B/CACNG3/CACNB2/CACNA1F/SCN1B/AKT2/GNAS	26
KEGG	hsa04024	cAMP signaling pathway	38/1364	221/8135	0.4601	0.6912	0.447	RAC2/NPY1R/NFKBIA/ABCC4/FXYD1/MAPK3/SOX9/PLD1/LIPE/GRIA2/PLCE1/F2R/ADCY8/RAP1B/EDN1/BAD/ATP2B1/TNNI3/ATP2A3/VAV2/MAPK10/MAP2K1/SLC9A1/PPP1CC/ADCY7/PIK3R3/ADCY6/TIAM1/ADORA1/CACNA1D/CREB3L2/CREB3/PIK3R2/CACNA1F/CRHR1/MYL9/AKT2/GNAS	38
KEGG	hsa04962	Vasopressin-regulated water reabsorption	8/1364	44/8135	0.4624	0.6915	0.4473	ARHGDIB/DYNC2LI1/DCTN2/ADCY6/CREB3L2/CREB3/DYNC1H1/GNAS	8
KEGG	hsa00730	Thiamine metabolism	3/1364	15/8135	0.4721	0.7029	0.4546	ALPL/AK1/THTPA	3
KEGG	hsa04020	Calcium signaling pathway	41/1364	240/8135	0.4746	0.7034	0.455	CD38/PDE1A/PLCG2/PLCB1/AGTR1/VEGFA/TPCN1/NTRK2/ASPH/PRKCB/CXCR4/P2RX5/PLCE1/PDGFD/F2R/ERBB2/FGF7/ADCY8/PLCD1/GNA11/ATP2B1/ORAI2/PDE1B/ATP2A3/FGF2/HTR2A/PPP3CA/EGFR/ITPKB/SLC25A6/ADCY7/MET/ITPR1/HTR2B/HGF/GNAL/ORAI3/CACNA1D/CACNA1F/MCOLN3/GNAS	41
KEGG	hsa00051	Fructose and mannose metabolism	6/1364	33/8135	0.4852	0.7127	0.461	TPI1/AKR1B10/PFKFB3/PMM1/ALDOC/AKR1B1	6
KEGG	hsa03410	Base excision repair	6/1364	33/8135	0.4852	0.7127	0.461	PARP3/PARP1/FEN1/POLD4/LIG3/POLD2	6
KEGG	hsa05010	Alzheimer disease	65/1364	384/8135	0.488	0.7137	0.4616	XBP1/PLCB1/LRP1/FZD4/LPL/TUBA4A/WNT5B/MAPK3/SLC39A8/APOE/FZD2/ATF6/FRAT2/FZD7/CHUK/MAP3K5/COX7A1/CYCS/FZD6/WIPI1/GSK3B/IL6/LRP5/BACE1/BACE2/BAD/KLC1/CSNK2A2/WNT5A/ATP2A3/RTN3/KRAS/CAPN2/MAPK10/NDUFV1/PPP3CA/MAP2K1/TUBB6/SLC25A6/WNT11/ITPR1/PIK3R3/COX5A/CASP9/COX6C/NDUFS4/NDUFA10/NDUFA13/PSMC3/KIF5C/CACNA1D/APH1B/CSF1/WNT10B/NDUFB7/FAS/PSMA5/PIK3R2/NRAS/CACNA1F/SLC39A6/AKT2/SLC39A14/ULK2/NDUFS7	65
KEGG	hsa03250	Viral life cycle - HIV-1	11/1364	63/8135	0.4936	0.7186	0.4648	MX2/APOBEC3G/CCR5/SAMHD1/CXCR4/PSIP1/SERINC5/PIN1/APOBEC3F/MLLT3/MX1	11
KEGG	hsa05214	Glioma	13/1364	75/8135	0.4957	0.7186	0.4648	PLCG2/MAPK3/PRKCB/KRAS/SHC1/EGFR/MAP2K1/PIK3R3/E2F3/PIK3R2/NRAS/AKT2/CCND1	13
KEGG	hsa04141	Protein processing in endoplasmic reticulum	29/1364	171/8135	0.5054	0.7295	0.4718	XBP1/HERPUD1/WFS1/SEC24A/ATF6/UBE2J1/UBE4B/PRKCSH/MAP3K5/NGLY1/CRYAB/MBTPS1/NSFL1C/PREB/SEC63/CANX/MAN1B1/SAR1B/HYOU1/CAPN2/MAPK10/DERL1/UBE2D1/MAN1C1/SKP1/HSPA6/MBTPS2/UGGT2/OS9	29
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/1364	22/8135	0.5169	0.7384	0.4776	ACAT1/PMVK/PDSS1/ZMPSTE24	4
KEGG	hsa00430	Taurine and hypotaurine metabolism	3/1364	16/8135	0.5177	0.7384	0.4776	CDO1/FMO2/FMO1	3
KEGG	hsa04120	Ubiquitin mediated proteolysis	24/1364	142/8135	0.5182	0.7384	0.4776	UBE2L6/UBE2I/UBE2J1/UBE4B/BIRC3/CDC20/UBA3/CBLB/SOCS1/SMURF2/UBE2E3/PML/KEAP1/UBE2C/DDB1/HERC2/TRIM32/FBXW7/UBE2D1/WWP2/SKP1/CUL4B/WWP1/RPS27A	24
KEGG	hsa04330	Notch signaling pathway	10/1364	59/8135	0.5394	0.7621	0.4929	DTX4/HEY1/LFNG/MAML1/HDAC1/NOTCH1/HES1/APH1B/HEY2/TLE3	10
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1364	53/8135	0.5406	0.7621	0.4929	PLCB1/PRKCB/PTH1R/ATP2B1/AP2M1/ADCY6/KL/DNM1/GNAS	9
KEGG	hsa04973	Carbohydrate digestion and absorption	8/1364	47/8135	0.5421	0.7621	0.4929	PLCB1/PRKCB/LCT/PIK3R3/CACNA1D/PIK3R2/SLC5A1/AKT2	8
KEGG	hsa03440	Homologous recombination	7/1364	41/8135	0.544	0.7621	0.4929	TOPBP1/RPA1/BLM/POLD4/POLD2/NBN/RBBP8	7
KEGG	hsa04724	Glutamatergic synapse	19/1364	114/8135	0.551	0.7635	0.4938	PLCB1/GNG12/SLC38A1/MAPK3/PLD1/PRKCB/GRIA2/TRPC1/GNG10/ADCY8/PPP3CA/ADCY7/ITPR1/SLC17A6/ADCY6/SHANK2/CACNA1D/PLA2G4C/GNAS	19
KEGG	hsa03013	Nucleocytoplasmic transport	18/1364	108/8135	0.5517	0.7635	0.4938	UBE2I/KPNA3/NUP210/NUP50/UPF3A/SAP18/UPF1/SUMO4/NMD3/KPNA2/NXF3/NUP62/IPO8/SENP2/CSE1L/XPOT/NXT1/NUP155	18
KEGG	hsa04614	Renin-angiotensin system	4/1364	23/8135	0.5542	0.7635	0.4938	AGTR1/CTSA/CPA3/CTSG	4
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	4/1364	23/8135	0.5542	0.7635	0.4938	PCK1/GLUD2/PCK2/AQP1	4
KEGG	hsa00120	Primary bile acid biosynthesis	3/1364	17/8135	0.5611	0.7666	0.4958	ACOX2/CH25H/CYP7B1	3
KEGG	hsa00910	Nitrogen metabolism	3/1364	17/8135	0.5611	0.7666	0.4958	CA12/GLUD2/CA6	3
KEGG	hsa03460	Fanconi anemia pathway	9/1364	54/8135	0.5647	0.7684	0.497	RPA1/RMI1/BLM/ERCC1/REV3L/FANCI/ATR/POLI/HES1	9
KEGG	hsa01200	Carbon metabolism	19/1364	115/8135	0.5675	0.7691	0.4974	PC/ME3/ACAT1/HIBCH/TPI1/ADPGK/IDH2/ESD/CAT/ECHS1/GLUD2/RGN/SDS/IDH3A/ALDOC/OGDHL/ALDH6A1/IDH3B/ADH5	19
KEGG	hsa00500	Starch and sucrose metabolism	6/1364	36/8135	0.5758	0.7771	0.5026	ENPP1/GYS1/PYGB/GYG1/AGL/UGP2	6
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1364	24/8135	0.5899	0.7929	0.5128	XYLT1/EXT2/EXTL2/XYLT2	4
KEGG	hsa00061	Fatty acid biosynthesis	3/1364	18/8135	0.602	0.8056	0.5211	ACSL5/ACACB/ACSBG2	3
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/1364	37/8135	0.6042	0.8056	0.5211	DDO/GLUD2/ASS1/ALDH5A1/ALDH4A1/ASRGL1	6
KEGG	hsa04340	Hedgehog signaling pathway	9/1364	56/8135	0.6113	0.8102	0.524	GAS1/CDON/ARRB1/GSK3B/SMURF2/SCUBE2/EVC/CCND2/CCND1	9
KEGG	hsa00052	Galactose metabolism	5/1364	31/8135	0.6125	0.8102	0.524	AKR1B10/LCT/GALT/AKR1B1/UGP2	5
KEGG	hsa01230	Biosynthesis of amino acids	12/1364	75/8135	0.619	0.8123	0.5254	PC/TPI1/IDH2/SDS/MAT2A/IDH3A/CBS/ALDOC/BCAT1/IDH3B/ASS1/ALDH18A1	12
KEGG	hsa04918	Thyroid hormone synthesis	12/1364	75/8135	0.619	0.8123	0.5254	PLCB1/GPX3/PRKCB/ADCY8/CANX/ASGR1/ADCY7/ITPR1/ADCY6/CREB3L2/CREB3/GNAS	12
KEGG	hsa05031	Amphetamine addiction	11/1364	69/8135	0.6232	0.8146	0.5269	PRKCB/SLC18A2/GRIA2/MAOA/PPP3CA/HDAC1/PPP1CC/CACNA1D/CREB3L2/CREB3/GNAS	11
KEGG	hsa01212	Fatty acid metabolism	9/1364	57/8135	0.6336	0.8249	0.5335	ACSL5/ACADVL/ACAT1/HADH/TECR/ECHS1/SCD/ELOVL4/ACSBG2	9
KEGG	hsa04915	Estrogen signaling pathway	22/1364	138/8135	0.6387	0.8275	0.5352	PLCB1/HBEGF/MAPK3/ADCY8/KRAS/GPER1/SHC1/EGFR/MAP2K1/ADCY7/ITPR1/PIK3R3/ADCY6/KRT32/CREB3L2/CREB3/HSPA6/PIK3R2/NRAS/AKT2/NCOA1/GNAS	22
KEGG	hsa05020	Prion disease	44/1364	273/8135	0.6405	0.8275	0.5352	RAC2/CCL5/C7/NCF1/TUBA4A/MAPK3/C6/COX7A1/CYCS/NCF4/NCF2/GSK3B/IL6/BAD/KLC1/CSNK2A2/MAPK10/NDUFV1/PPP3CA/TUBB6/SLC25A6/SOD1/ITPR1/PIK3R3/COX5A/CASP9/COX6C/NDUFS4/NOTCH1/NDUFA10/NDUFA13/PSMC3/KIF5C/CACNA1D/MAPK13/CREB3L2/NDUFB7/CREB3/HSPA6/PSMA5/CAV1/PIK3R2/CACNA1F/NDUFS7	44
KEGG	hsa04976	Bile secretion	14/1364	89/8135	0.6477	0.8335	0.5391	ABCC4/EPHX1/ADCY8/AQP9/ABCC3/SLC4A2/RXRA/SLC9A1/ADCY7/ADCY6/AQP1/SLC5A1/GNAS/UGT2B4	14
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1364	26/8135	0.656	0.8398	0.5432	GPAA1/PIGT/PIGZ/PIGQ	4
KEGG	hsa00513	Various types of N-glycan biosynthesis	6/1364	39/8135	0.6577	0.8398	0.5432	FUT8/B4GALT3/MGAT4C/MAN1B1/MAN2A1/MAN1C1	6
KEGG	hsa03050	Proteasome	7/1364	46/8135	0.6717	0.85	0.5498	PSMB8/PSMB9/PSME1/PSMC3/IFNG/PSMA5/PSMB10	7
KEGG	hsa04217	Necroptosis	25/1364	159/8135	0.6717	0.85	0.5498	TNFAIP3/IFNAR2/TNFSF10/BIRC3/STAT1/PARP1/STAT4/GLUD2/JAK2/IRF9/USP21/PYGB/CAPN2/MAPK10/CASP1/SLC25A6/FTL/TICAM1/CHMP7/SPATA2L/PLA2G4C/FAS/IFNG/SQSTM1/STAT6	25
KEGG	hsa00100	Steroid biosynthesis	3/1364	20/8135	0.6759	0.85	0.5498	LBR/SOAT1/LIPA	3
KEGG	hsa00670	One carbon pool by folate	3/1364	20/8135	0.6759	0.85	0.5498	MTHFD2/TYMS/GART	3
KEGG	hsa00062	Fatty acid elongation	4/1364	27/8135	0.6862	0.8597	0.556	HADH/TECR/ECHS1/ELOVL4	4
KEGG	hsa05017	Spinocerebellar ataxia	22/1364	143/8135	0.7062	0.8767	0.567	XBP1/PLCB1/PRKCB/GRIA2/MAP3K5/CYCS/WIPI1/RORA/ATXN10/ATP2A3/MAPK10/SLC25A6/KAT5/ITPR1/PIK3R3/FGF14/PSMC3/PSMA5/VLDLR/PIK3R2/AKT2/ULK2	22
KEGG	hsa00010	Glycolysis / Gluconeogenesis	10/1364	67/8135	0.7068	0.8767	0.567	ALDH3A2/ALDH7A1/PCK1/TPI1/ADPGK/PCK2/ALDOC/ALDH3B1/ADH5/ADH1C	10
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1364	14/8135	0.7077	0.8767	0.567	FUT8/B4GALT3	2
KEGG	hsa03010	Ribosome	24/1364	158/8135	0.7356	0.9038	0.5846	RPLP0/RPL15/RPL8/RPL7/RPS18/RPS28/RPS23/RPL41/RPS9/RPS15/RPL3/RPL12/RPL24/RPLP1/RPL29/RPL30/MRPL23/RPS5/RPL34/RPL10A/RPL35A/RPS27A/MRPS18A/RPL9	24
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1364	15/8135	0.7439	0.9038	0.5846	B3GALNT1/NAGA	2
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	5/1364	36/8135	0.745	0.9038	0.5846	CD38/ENPP1/NAMPT/PNP/SIRT3	5
KEGG	hsa05415	Diabetic cardiomyopathy	31/1364	203/8135	0.746	0.9038	0.5846	PDK2/RAC2/PLCB1/AGTR1/NCF1/SMAD3/PRKCB/COX7A1/NCF4/PARP1/NCF2/GSK3B/TNNI3/ATP2A3/TGFB2/GYS1/MAPK10/NDUFV1/SLC25A6/PPP1CC/PIK3R3/COX5A/COX6C/NDUFS4/NDUFA10/NDUFA13/MAPK13/NDUFB7/PIK3R2/AKT2/NDUFS7	31
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	75/1364	476/8135	0.7469	0.9038	0.5846	XBP1/TNFRSF1B/PLCB1/GPX3/FZD4/UBE2L6/TUBA4A/WNT5B/MAPK3/DAXX/PRKCB/UCHL1/FZD2/ATF6/FRAT2/GRIA2/UBE2J1/FZD7/MAP3K5/COX7A1/CYCS/FZD6/WIPI1/GSK3B/SNCAIP/IL6/CAT/LRP5/BAD/KLC1/CSNK2A2/TANK/WNT5A/ATP2A3/DCTN3/KRAS/DNALI1/PINK1/CAPN2/MAPK10/NDUFV1/DCTN2/PPP3CA/MAP2K1/TUBB6/SLC25A6/DERL1/SOD1/WNT11/ITPR1/COX5A/CASP9/COX6C/OPTN/NDUFS4/NDUFA10/NDUFA13/PSMC3/KIF5C/CACNA1D/CSF1/MAPK13/WNT10B/DNAH6/NDUFB7/FAS/PSMA5/NRAS/CACNA1F/RPS27A/SQSTM1/MAP2K6/ULK2/NDUFS7/RAB8A	75
KEGG	hsa04727	GABAergic synapse	13/1364	89/8135	0.75	0.9038	0.5846	GNG12/SLC38A1/PRKCB/GABARAPL1/GNG10/ADCY8/GABRB1/GABRA4/ADCY7/ADCY6/CACNA1D/CACNA1F/GABRR1	13
KEGG	hsa05012	Parkinson disease	41/1364	266/8135	0.7501	0.9038	0.5846	XBP1/UBE2L6/TUBA4A/SLC39A8/DAXX/SLC18A2/UCHL1/ATF6/UBE2J1/MAP3K5/COX7A1/CYCS/SNCAIP/MAOA/KLC1/KEAP1/PINK1/MAPK10/NDUFV1/TUBB6/SLC25A6/SOD1/ITPR1/COX5A/CASP9/COX6C/NDUFS4/NDUFA10/NDUFA13/PSMC3/GNAL/KIF5C/TXN/NDUFB7/PSMA5/TXN2/SLC39A6/RPS27A/SLC39A14/GNAS/NDUFS7	41
KEGG	hsa00310	Lysine degradation	9/1364	63/8135	0.7514	0.9038	0.5846	ALDH3A2/ALDH7A1/ACAT1/HADH/EZH1/EZH2/SMYD2/ECHS1/MECOM	9
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/1364	23/8135	0.7669	0.9192	0.5946	FUT4/B4GALT3/CHST10	3
KEGG	hsa04713	Circadian entrainment	14/1364	97/8135	0.7712	0.921	0.5957	PLCB1/GNG12/MAPK3/PRKCB/GRIA2/GNG10/ADCY8/PER3/ADCY7/ITPR1/ADCY6/CACNA1D/PRKG1/GNAS	14
KEGG	hsa04710	Circadian rhythm	4/1364	31/8135	0.7879	0.9376	0.6064	RORA/PER3/CRY2/SKP1	4
KEGG	hsa04970	Salivary secretion	13/1364	93/8135	0.804	0.9463	0.6121	CD38/PLCB1/PRKCB/ADCY8/ATP2B1/SLC4A2/LYZ/SLC9A1/ADCY7/ITPR1/ADCY6/PRKG1/GNAS	13
KEGG	hsa04371	Apelin signaling pathway	20/1364	139/8135	0.8068	0.9463	0.6121	PLCB1/GNG12/AGTR1/PLIN1/SMAD3/MAPK3/LIPE/GNG10/ADCY8/KRAS/MAP2K1/SLC9A1/ADCY7/ITPR1/ADCY6/HDAC4/PRKCE/NRAS/AKT2/CCND1	20
KEGG	hsa04136	Autophagy - other	4/1364	32/8135	0.8088	0.9463	0.6121	GABARAPL1/PPP2CA/WIPI1/ULK2	4
KEGG	hsa04215	Apoptosis - multiple species	4/1364	32/8135	0.8088	0.9463	0.6121	BIRC3/CYCS/MAPK10/CASP9	4
KEGG	hsa04978	Mineral absorption	8/1364	60/8135	0.8107	0.9463	0.6121	CYBRD1/ATP2B1/TF/SLC31A1/FTL/ATOX1/TRPM6/SLC5A1	8
KEGG	hsa04922	Glucagon signaling pathway	15/1364	107/8135	0.8136	0.9463	0.6121	PLCB1/SIK1/FOXO1/PCK1/ACACB/SIK2/GYS1/PYGB/PPP3CA/PCK2/ITPR1/CREB3L2/CREB3/AKT2/GNAS	15
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1364	25/8135	0.8152	0.9463	0.6121	PLA2G2D/PLA2G2F/PLA2G4C	3
KEGG	hsa05033	Nicotine addiction	5/1364	40/8135	0.8243	0.9536	0.6168	GRIA2/GABRB1/GABRA4/SLC17A6/GABRR1	5
KEGG	hsa00511	Other glycan degradation	2/1364	18/8135	0.8303	0.9571	0.6191	FUCA1/MAN2B2	2
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	9/1364	69/8135	0.84	0.9619	0.6222	HPGDS/GSTA4/GSTT1/EPHX1/GSTK1/GSTM2/GSTM1/MGST3/UGT2B4	9
KEGG	hsa04971	Gastric acid secretion	10/1364	76/8135	0.8418	0.9619	0.6222	PLCB1/PRKCB/ADCY8/KCNJ2/SLC4A2/SLC9A1/ADCY7/ITPR1/ADCY6/GNAS	10
KEGG	hsa03015	mRNA surveillance pathway	13/1364	97/8135	0.8491	0.9619	0.6222	PPP2CA/UPF3A/PPP2R5D/SAP18/PPP2R1A/PABPC1/UPF1/DAZAP1/NXF3/PPP1CC/PPP2R1B/PABPC3/NXT1	13
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1364	49/8135	0.8528	0.9619	0.6222	CYB5R3/CYB5R1/PMM1/GALT/UGP2/CYB5R4	6
KEGG	hsa05030	Cocaine addiction	6/1364	49/8135	0.8528	0.9619	0.6222	SLC18A2/GRIA2/MAOA/CREB3L2/CREB3/GNAS	6
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1364	27/8135	0.8547	0.9619	0.6222	FUT4/B3GALNT1/B4GALT3	3
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/1364	27/8135	0.8547	0.9619	0.6222	TECR/SCD/ELOVL4	3
KEGG	hsa04975	Fat digestion and absorption	5/1364	43/8135	0.8697	0.9718	0.6286	PLA2G2D/ACAT1/AGPAT1/PLA2G2F/FABP1	5
KEGG	hsa04714	Thermogenesis	33/1364	232/8135	0.8745	0.9718	0.6286	PPARG/PLIN1/ACSL5/SMARCA2/LIPE/MAP3K5/COX7A1/RPS6KA1/ADCY8/NDUFAF3/KRAS/NDUFV1/PNPLA2/TSC1/ADCY7/ADCY6/COX5A/COX6C/NDUFS4/SMARCD3/NDUFA10/NDUFA13/MAPK13/CREB3L2/NDUFB7/CREB3/PRKG1/ARID1A/NRAS/TSC2/RHEB/GNAS/NDUFS7	33
KEGG	hsa04911	Insulin secretion	11/1364	86/8135	0.8749	0.9718	0.6286	PLCB1/PRKCB/ADCY8/GNA11/ADCY7/ADCY6/CACNA1D/CREB3L2/CREB3/CACNA1F/GNAS	11
KEGG	hsa00512	Mucin type O-glycan biosynthesis	4/1364	36/8135	0.876	0.9718	0.6286	GALNT10/GCNT1/GALNT6/GALNT11	4
KEGG	hsa04913	Ovarian steroidogenesis	6/1364	51/8135	0.8781	0.9718	0.6286	ADCY8/ALOX5/ADCY7/ADCY6/PLA2G4C/GNAS	6
KEGG	hsa04260	Cardiac muscle contraction	11/1364	87/8135	0.884	0.9747	0.6304	ASPH/COX7A1/TNNI3/ATP2A3/SLC9A1/COX5A/COX6C/CACNA1D/CACNG3/CACNB2/CACNA1F	11
KEGG	hsa00591	Linoleic acid metabolism	3/1364	29/8135	0.8866	0.9747	0.6304	PLA2G2D/PLA2G2F/PLA2G4C	3
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1364	30/8135	0.9001	0.9862	0.6379	HYI/ACAT1/CAT	3
KEGG	hsa00220	Arginine biosynthesis	2/1364	22/8135	0.9045	0.9878	0.6389	GLUD2/ASS1	2
KEGG	hsa03450	Non-homologous end-joining	1/1364	13/8135	0.9082	0.9886	0.6394	FEN1	1
KEGG	hsa04721	Synaptic vesicle cycle	9/1364	78/8135	0.9243	1	0.6468	SLC18A2/STXBP1/RIMS1/AP2M1/SLC17A6/SLC6A7/CPLX2/UNC13B/DNM1	9
KEGG	hsa04977	Vitamin digestion and absorption	2/1364	24/8135	0.929	1	0.6468	SLC19A3/SLC5A6	2
KEGG	hsa05322	Systemic lupus erythematosus	17/1364	136/8135	0.9322	1	0.6468	HLA-DOB/C7/C6/TRIM21/FCGR3B/CD40/HLA-DMB/FCGR2A/HLA-DMA/CD40LG/HLA-DPA1/CTSG/HLA-DRB4/IFNG/FCGR1A/HLA-DPB1/CD86	17
KEGG	hsa04130	SNARE interactions in vesicular transport	3/1364	33/8135	0.9323	1	0.6468	BNIP1/VAMP5/STX11	3
KEGG	hsa05014	Amyotrophic lateral sclerosis	51/1364	364/8135	0.9373	1	0.6468	XBP1/TNFRSF1B/GPX3/TUBA4A/DAXX/ATF6/PFN2/GRIA2/MAP3K5/COX7A1/CYCS/WIPI1/NUP210/CAT/NUP50/HNRNPA1/BAD/KLC1/TANK/DCTN3/DNALI1/PINK1/NDUFV1/DCTN2/NXF3/PPP3CA/TUBB6/CASP1/NUP62/DERL1/SOD1/COX5A/CASP9/COX6C/OPTN/NDUFS4/NDUFA10/NDUFA13/PSMC3/KIF5C/MAPK13/DNAH6/NDUFB7/PSMA5/SQSTM1/NXT1/NUP155/MAP2K6/ULK2/NDUFS7/RAB8A	51
KEGG	hsa05206	MicroRNAs in cancer	42/1364	310/8135	0.9509	1	0.6468	PLCG2/BCL2L2/EFNA5/ZFPM2/MAPK3/VEGFA/UBE2I/DNMT1/PRKCB/DDIT4/SPRY2/CCNE1/ERBB2/EZH2/RECK/SOCS1/PIM1/TGFB2/KRAS/EFNA1/CCNG1/SHC1/EGFR/MAP2K1/TIMP3/HDAC1/MAPK7/MET/PIK3R3/RDX/NOTCH1/ITGB3/MARCKS/HDAC4/E2F3/PRKCE/CCND2/PIK3R2/THBS1/CD44/NRAS/CCND1	42
KEGG	hsa00600	Sphingolipid metabolism	5/1364	52/8135	0.9509	1	0.6468	UGCG/SGPL1/CERS6/PSAP/CERS4	5
KEGG	hsa00830	Retinol metabolism	7/1364	68/8135	0.9526	1	0.6468	DHRS9/RETSAT/DHRS3/ALDH1A3/ADH5/ADH1C/UGT2B4	7
KEGG	hsa05016	Huntington disease	41/1364	306/8135	0.9572	1	0.6468	PLCB1/GPX3/PPARG/TUBA4A/GRIA2/MAP3K5/COX7A1/CYCS/WIPI1/POLR2E/KLC1/DCTN3/DNALI1/MAPK10/NDUFV1/DCTN2/TUBB6/HDAC1/SLC25A6/POLR2L/SOD1/AP2M1/ITPR1/COX5A/CASP9/COX6C/NDUFS4/NDUFA10/NDUFA13/PSMC3/KIF5C/DNAH6/CREB3L2/NDUFB7/POLR2I/CREB3/PSMA5/POLR2F/POLR2D/ULK2/NDUFS7	41
KEGG	hsa03022	Basal transcription factors	4/1364	45/8135	0.9574	1	0.6468	GTF2IRD1/ERCC2/GTF2F1/TAF11	4
KEGG	hsa01250	Biosynthesis of nucleotide sugars	3/1364	37/8135	0.9604	1	0.6468	PMM1/GALT/UGP2	3
KEGG	hsa00030	Pentose phosphate pathway	2/1364	30/8135	0.9716	1	0.6468	RGN/ALDOC	2
KEGG	hsa05168	Herpes simplex virus 1 infection	67/1364	495/8135	0.9817	1	0.6468	TAP1/SYK/CCL5/HLA-DOB/CFP/NFKBIA/TRAF3/IFNAR2/MYD88/TAPBP/TLR2/DAXX/BIRC3/CHUK/HLA-DMB/CYCS/STAT1/HLA-A/OAS2/HLA-E/ZNF267/HLA-F/IL6/IRF7/HLA-C/BAD/HLA-DMA/PML/CD74/ZNF184/JAK2/ZNF606/SRSF8/IRAK4/IRF9/ZNF415/ZNF124/NXF3/HLA-DPA1/TNFRSF14/HLA-B/PILRA/TICAM1/IFIH1/TSC1/SRPK1/PPP1CC/ZNF468/ZNF282/PTPN11/HLA-DRB4/PIK3R3/CASP9/ITGB3/HLA-G/FAS/IFNG/ZNF665/DDX58/PIK3R2/SRSF6/B2M/HLA-DPB1/TSC2/AKT2/RHEB/ZNF200	67
KEGG	hsa00140	Steroid hormone biosynthesis	5/1364	61/8135	0.9832	1	0.6468	AKR1C1/CYP7B1/HSD11B2/STS/UGT2B4	5
KEGG	hsa03040	Spliceosome	16/1364	147/8135	0.9835	1	0.6468	PRPF8/TCERG1/PRPF6/HNRNPA1/SF3B2/SRSF8/SNRPA/PRPF31/PUF60/LSM3/PRPF40A/HSPA6/SRSF6/SMNDC1/U2AF2/BUD31	16
KEGG	hsa04950	Maturity onset diabetes of the young	1/1364	26/8135	0.9916	1	0.6468	HES1	1
KEGG	hsa04966	Collecting duct acid secretion	1/1364	27/8135	0.993	1	0.6468	SLC12A7	1
KEGG	hsa04742	Taste transduction	7/1364	86/8135	0.9936	1	0.6468	PDE1A/PLCB1/ADCY8/GABRA4/PDE1B/ADCY6/SCN9A	7
KEGG	hsa04974	Protein digestion and absorption	9/1364	103/8135	0.9938	1	0.6468	COL14A1/CPA3/SLC36A1/COL16A1/COL15A1/CPB1/SLC3A2/COL8A2/COL21A1	9
KEGG	hsa05110	Vibrio cholerae infection	3/1364	50/8135	0.9938	1	0.6468	PLCG2/KDELR3/GNAS	3
KEGG	hsa04744	Phototransduction	1/1364	29/8135	0.9952	1	0.6468	GUCA1A	1
KEGG	hsa05034	Alcoholism	18/1364	187/8135	0.9983	1	0.6468	GNG12/MAPK3/SLC29A1/NTRK2/SLC18A2/GNG10/MAOA/KRAS/SHC1/MAP2K1/HDAC1/PPP1CC/CAMKK2/HDAC4/CREB3L2/CREB3/NRAS/GNAS	18
KEGG	hsa03018	RNA degradation	5/1364	79/8135	0.9984	1	0.6468	PABPC1/CNOT7/LSM3/PARN/PABPC3	5
KEGG	hsa04080	Neuroactive ligand-receptor interaction	40/1364	353/8135	0.9986	1	0.6468	GZMA/NPY1R/GHR/FPR1/AGTR1/C5AR1/PTH1R/S1PR1/PENK/ADORA3/GRIA2/MC3R/P2RX5/NMB/F2R/LPAR1/GABRB1/GABRA4/EDN1/P2RY6/THRB/PTGER4/DRD4/HTR2A/S1PR4/C3AR1/CTSG/HTR2B/ADORA1/S1PR5/CALCR/GAL/PARD3/MLNR/P2RY13/FPR2/GABRR1/VIPR1/CRHR1/NMU	40
KEGG	hsa00190	Oxidative phosphorylation	10/1364	134/8135	0.9995	1	0.6468	COX7A1/CYCS/NDUFV1/COX5A/COX6C/NDUFS4/NDUFA10/NDUFA13/NDUFB7/NDUFS7	10
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	7/1364	109/8135	0.9996	1	0.6468	CSNK2A2/NMD3/NXF3/EIF6/NXT1/NHP2/RPP40	7
KEGG	hsa04740	Olfactory transduction	9/1364	440/8135	1	1	0.6468	PDE1A/ARRB1/PDE1B/OR11A1/OR3A1/GNAL/NCALD/PRKG1/OR7C1	9