ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	99/1836	222/8135	1.393e-13	4.653e-11	3.167e-11	AKT2/PRKACB/IL15/BCL2L1/PTTG1/IL15RA/ATM/MAPK9/POLB/CHEK1/TGFBR2/EGR1/IL2RG/CCNA2/MAD2L1/IL1R1/LCK/VDAC3/CCNE2/CD3E/HLA-DOB/TRRAP/XPO1/CRTC1/ADCY7/CD3D/E2F3/JUN/ADCY6/CD3G/HLA-F/ITGB2/IL2RB/NFKB2/CCNB2/JAK3/CDC20/ZFP36/CDC16/PIK3CB/MAP2K4/HLA-DMB/TERT/CD40/TGFB2/SRF/STAT5A/NFATC4/KAT2B/CDKN1A/BUB1B/CCNE1/CREBBP/MSX2/PPP3CC/HLA-C/CSF2/MYC/CCND3/HLA-DPA1/NRAS/PIK3R1/PIK3CA/HLA-DPB1/HLA-G/HLA-DMA/CRTC3/GPS2/JAK1/ATR/ETS1/TNFRSF1A/NFKB1/ADCY8/SMAD2/PRKACA/HLA-A/RELB/FOS/TP53/ITGAL/CDKN2B/BUB3/VAC14/IL2RA/SLC25A31/HLA-DRA/TLN2/LTBR/NFYB/PPP3CB/PRKACG/MAPK1/TBP/SLC25A4/CDC23/B2M/XIAP/ADCY1	99
KEGG	hsa05169	Epstein-Barr virus infection	90/1836	202/8135	1.969e-12	3.288e-10	2.238e-10	CXCL10/AKT2/PLCG2/IRF9/FAS/TAP1/MAP2K7/STAT1/MAPK14/MAPK9/BLNK/OAS2/ENTPD1/GADD45B/TAB2/HES1/CCNA2/CCNE2/CD3E/HLA-DOB/CD3D/E2F3/JUN/TRAF6/CD3G/SYK/HLA-F/TAPBP/NFKB2/PSMC2/RUNX3/JAK3/RBPJL/CD247/DDB2/CD19/PIK3CB/MAP2K4/HLA-DMB/PSMD3/CD40/DDX58/NFKBIE/BTK/TRAF3/CDKN1A/CCNE1/CASP3/TBK1/OAS1/IFNAR1/HLA-C/MYC/CCND3/HLA-DPA1/TRAF5/BAK1/IFNA1/PIK3R1/PIK3CA/HLA-DPB1/HLA-G/MAP3K7/NCOR2/PSMD8/HLA-DMA/IRF7/JAK1/FADD/NFKB1/OAS3/HLA-A/RELB/CDKN1B/TP53/ITGAL/MAPK13/HDAC1/IFNAR2/MYD88/TRADD/PSMD4/HLA-DRA/CR2/RBPJ/EIF2AK2/CD58/IRAK4/B2M/IFNA5	90
KEGG	hsa05164	Influenza A	72/1836	171/8135	6.804e-09	7.575e-07	5.157e-07	CXCL10/AKT2/IRF9/JAK2/IFIH1/FAS/SOCS3/TNFSF10/STAT1/CCL5/OAS2/HLA-DOB/PRKCB/TLR3/XPO1/CASP1/TRIM25/MX1/TNFRSF10B/TPSAB1/PIK3CB/HLA-DMB/RAB11A/NXT2/DDX58/TRAF3/TPSD1/TLR7/MX2/CASP3/CREBBP/TBK1/RNASEL/OAS1/IFNAR1/CCND3/HLA-DPA1/NXF3/BAK1/TPSB2/IFNA1/PIK3R1/PIK3CA/HLA-DPB1/IL18/IFNGR2/HLA-DMA/IRF7/ADAR/IFNG/JAK1/FADD/PRSS2/TNFRSF1A/NFKB1/TMPRSS2/OAS3/FASLG/IFNAR2/NLRX1/MYD88/TRADD/SLC25A31/HLA-DRA/MAPK1/EIF2AK2/IRAK4/PYCARD/SLC25A4/DNAJB1/PLG/IFNA5	72
KEGG	hsa04380	Osteoclast differentiation	57/1836	128/8135	2.387e-08	1.993e-06	1.357e-06	AKT2/PLCG2/IRF9/MAP2K7/SOCS3/JUNB/STAT1/MAPK14/MAPK9/BLNK/TGFBR2/TAB2/IL1R1/LCK/FCGR2B/FOSL2/JUN/SIRPG/TRAF6/SYK/NFKB2/NCF1/CSF1R/PIK3CB/SQSTM1/BTK/TGFB2/FOSB/IFNAR1/PPP3CC/CSF1/ITGB3/PIK3R1/PIK3CA/LILRB4/NOX1/MAP3K7/NCF4/IFNGR2/LILRB2/IFNG/JAK1/LILRB5/TNFRSF1A/NFKB1/CYBA/TNFSF11/RELB/FOS/MAPK13/IFNAR2/JUND/PPP3CB/LILRA5/MAPK1/PPARG/LILRA2	57
KEGG	hsa05170	Human immunodeficiency virus 1 infection	81/1836	212/8135	1.444e-07	9.645e-06	6.566e-06	AKT2/PLCG2/FAS/BCL2L1/TAP1/MAP2K7/CCR5/MAPK14/ATM/MAPK9/CHEK1/GNAI3/TAB2/PAK2/CCNB1/CD3E/PRKCB/FBXW11/RBX1/APOBEC3G/CD3D/PXN/JUN/APOBEC3B/TRAF6/AP1S2/CD3G/GNA11/AP1S1/CDK1/HLA-F/TAPBP/CCNB2/PAK3/CD247/PIK3CB/APOBEC3C/CXCR4/ITPR2/WEE1/NFATC4/TNFRSF1B/CASP3/TBK1/GNG3/PPP3CC/HLA-C/TRAF5/ITPR1/BAK1/IFNA1/NRAS/PIK3R1/PIK3CA/HLA-G/MAP3K7/RAC2/FADD/ATR/TNFRSF1A/NFKB1/RNF7/HLA-A/CALM1/FOS/FASLG/MAPK13/MYD88/TRADD/TRIM5/GNB3/PPP3CB/PRKCG/PAK1/AP1G2/ITPR3/MAPK1/CALML3/IRAK4/B2M/IFNA5	81
KEGG	hsa05162	Measles	57/1836	139/8135	7.29e-07	3.487e-05	2.374e-05	AKT2/IRF9/IFIH1/FAS/BCL2L1/STAT1/MAPK9/OAS2/IL2RG/TAB2/SLAMF1/FCGR2B/CCNE2/CD3E/CD3D/JUN/TRAF6/CD3G/IL2RB/MX1/JAK3/PIK3CB/DDX58/TRAF3/STAT5A/TLR7/MX2/CCNE1/CASP3/TBK1/OAS1/IFNAR1/CCND3/BAK1/IFNA1/PIK3R1/PIK3CA/MAP3K7/IRF7/ADAR/JAK1/HSPA1L/FADD/NFKB1/OAS3/EIF2AK1/CDKN1B/FOS/FASLG/TP53/IFNAR2/MYD88/TRADD/IL2RA/EIF2AK2/IRAK4/IFNA5	57
KEGG	hsa04658	Th1 and Th2 cell differentiation	42/1836	92/8135	7.309e-07	3.487e-05	2.374e-05	JAK2/STAT1/MAPK14/MAPK9/IL2RG/LCK/CD3E/HLA-DOB/PRKCQ/CD3D/IL13/JUN/STAT4/CD3G/IL2RB/RUNX3/JAK3/RBPJL/CD247/HLA-DMB/NFKBIE/STAT5A/STAT6/IL5/PPP3CC/HLA-DPA1/HLA-DPB1/IFNGR2/HLA-DMA/LAT/IFNG/JAK1/NFKB1/FOS/MAPK13/MAML1/IL2RA/HLA-DRA/PPP3CB/RBPJ/MAPK1/MAML3	42
KEGG	hsa04659	Th17 cell differentiation	47/1836	108/8135	9.124e-07	3.809e-05	2.593e-05	JAK2/STAT1/IL27RA/MAPK14/MAPK9/TGFBR2/IL21R/RXRB/IL2RG/IL1R1/LCK/CD3E/HLA-DOB/IL6ST/PRKCQ/CD3D/JUN/CD3G/IL2RB/JAK3/HSP90AA1/CD247/HLA-DMB/NFKBIE/STAT5A/STAT6/PPP3CC/HLA-DPA1/HLA-DPB1/IFNGR2/HLA-DMA/LAT/IFNG/JAK1/NFKB1/SMAD2/FOXP3/RXRG/FOS/MAPK13/IL2RA/HLA-DRA/PPP3CB/MAPK1/RARA/AHR/RXRA	47
KEGG	hsa04064	NF-kappa B signaling pathway	45/1836	104/8135	1.879e-06	6.973e-05	4.747e-05	PLCG2/BCL2L1/ATM/BLNK/BIRC3/MALT1/GADD45B/TAB2/PARP1/IL1R1/LCK/PRKCB/TRAF1/PRKCQ/TRAF6/SYK/TRIM25/NFKB2/CD40/DDX58/CARD14/BTK/TRAF3/CCL13/TRAF5/CD40LG/MAP3K7/LAT/LY96/TNFRSF1A/NFKB1/LTB/TNFSF11/CCL19/CD14/RELB/PIAS4/PTGS2/MYD88/CCL21/TRADD/LTBR/PIDD1/IRAK4/XIAP	45
KEGG	hsa05140	Leishmaniasis	36/1836	77/8135	2.245e-06	7.499e-05	5.105e-05	JAK2/STAT1/EEF1A1/MAPK14/TAB2/HLA-DOB/PRKCB/JUN/TRAF6/ITGA4/ITGB2/NCF1/HLA-DMB/TGFB2/HLA-DPA1/PTPN6/CR1/HLA-DPB1/MAP3K7/NCF4/IFNGR2/HLA-DMA/MARCKSL1/IFNG/JAK1/NFKB1/CYBA/FOS/PTGS2/MAPK13/MYD88/HLA-DRA/CYBB/IL10/MAPK1/IRAK4	36
KEGG	hsa04010	MAPK signaling pathway	100/1836	294/8135	3.289e-06	9.987e-05	6.799e-05	AKT2/PRKACB/FAS/PTPN7/MAP2K7/FGFR1/DUSP1/MAPK14/MAPK9/TGFBR2/TAOK3/GADD45B/TAB2/PAK2/IL1R1/PRKCB/CACNA1I/STMN1/RASGRP1/RASA1/JUN/FGFR4/TRAF6/FGF21/CACNA1B/NTRK2/MAP3K11/FLNB/NR4A1/CACNG2/NFKB2/RPS6KA1/NTRK1/MAPK8IP2/CDC25B/PPP5C/PLA2G4A/CSF1R/MAP2K4/DUSP9/EGFR/TGFB2/SRF/KITLG/CASP3/ARAF/CACNG1/PPP3CC/MYC/MAP4K1/CSF1/RPS6KA5/RASGRF1/PLA2G4C/NRAS/CACNA1E/MAP3K7/RAC2/NLK/TAOK1/CACNA1H/CACNA1S/HSPA1L/EFNA5/FGF17/TNFRSF1A/NFKB1/MAX/PRKACA/FLT3LG/CD14/RELB/MAPK8IP3/FOS/FASLG/EFNA4/TP53/MAPK13/ANGPT2/EREG/RASGRP3/MYD88/TRADD/FGF5/JUND/FGF3/RRAS/MAP3K5/RPS6KA4/PPP3CB/PDGFC/PRKCG/PAK1/AREG/MAPT/PRKACG/MAPK1/IRAK4/BDNF/PDGFA	100
KEGG	hsa04110	Cell cycle	51/1836	126/8135	4.357e-06	0.0001213	8.256e-05	PTTG1/PCNA/ATM/CHEK1/CDC7/GADD45B/CCNA2/MAD2L1/CCNB1/CCNE2/RBX1/MCM5/E2F3/CDK7/MCM2/TTK/CDK1/CDC6/MCM3/MCM6/CDC45/SMC1A/CCNB2/CDC20/CDC25B/CDC16/YWHAZ/YWHAH/TGFB2/WEE1/CDKN1A/BUB1B/CCNE1/CREBBP/ORC4/MYC/CCND3/ZBTB17/BUB1/ATR/CDKN2D/ORC3/SMAD2/CDKN1B/TP53/CDKN2B/HDAC1/E2F4/BUB3/RBL1/CDC23	51
KEGG	hsa04640	Hematopoietic cell lineage	42/1836	99/8135	7.533e-06	0.0001935	0.0001318	CD38/IL1R1/CD3E/HLA-DOB/CD8A/CD2/CD3D/MS4A1/ITGA4/CD3G/EPOR/CSF1R/CD19/HLA-DMB/KITLG/IL7/IL7R/IL5/CSF2/CD37/HLA-DPA1/CSF1/ITGB3/CD5/CR1/HLA-DPB1/HLA-DMA/DNTT/FLT3LG/CD14/EPO/CD33/CD1D/GP9/TFRC/IL11/IL2RA/HLA-DRA/CD24/CR2/CD7/CSF3	42
KEGG	hsa04218	Cellular senescence	59/1836	156/8135	1.024e-05	0.0002443	0.0001663	AKT2/HIPK2/MAPK14/ATM/CHEK1/TGFBR2/GADD45B/CCNA2/CCNB1/VDAC3/CCNE2/FBXW11/HIPK1/E2F3/RAD1/CDK1/HLA-F/CCNB2/PIK3CB/PPP1CA/ITPR2/PPID/SQSTM1/TGFB2/NFATC4/CDKN1A/CCNE1/PPP3CC/HLA-C/MYC/CCND3/ITPR1/RHEB/NRAS/PIK3R1/PIK3CA/HLA-G/ATR/ETS1/NFKB1/ZFP36L1/SMAD2/FOXM1/HLA-A/CALM1/TP53/CDKN2B/MAPK13/E2F4/FOXO3/SLC25A31/RBL1/NBN/RRAS/PPP3CB/ITPR3/MAPK1/CALML3/SLC25A4	59
KEGG	hsa05330	Allograft rejection	21/1836	38/8135	1.2e-05	0.0002672	0.0001819	FAS/HLA-DOB/PRF1/HLA-F/CD86/HLA-DMB/CD40/IL5/HLA-C/HLA-DPA1/CD40LG/HLA-DPB1/HLA-G/CD80/HLA-DMA/IFNG/HLA-A/GZMB/FASLG/HLA-DRA/IL10	21
KEGG	hsa04660	T cell receptor signaling pathway	43/1836	104/8135	1.289e-05	0.0002692	0.0001832	AKT2/MAP2K7/MAPK14/MAPK9/MALT1/PAK2/PTPRC/LCK/CD3E/CD8A/RASGRP1/PRKCQ/CD3D/JUN/NCK1/CD3G/ITK/PAK3/CTLA4/CD247/PIK3CB/VAV2/NFKBIE/IL5/PPP3CC/CSF2/CD40LG/PTPN6/NRAS/PIK3R1/PIK3CA/MAP3K7/LAT/VAV1/IFNG/NFKB1/FOS/MAPK13/VAV3/PPP3CB/PAK1/IL10/MAPK1	43
KEGG	hsa05161	Hepatitis B	60/1836	162/8135	1.828e-05	0.0003591	0.0002445	AKT2/JAK2/IFIH1/FAS/MAP2K7/PCNA/STAT1/MAPK14/MAPK9/TGFBR2/TAB2/CCNA2/VDAC3/CCNE2/PRKCB/TLR3/E2F3/JUN/STAT4/TRAF6/JAK3/DDB2/PIK3CB/MAP2K4/YWHAZ/DDX58/TGFB2/TRAF3/STAT5A/NFATC4/CDKN1A/STAT6/CCNE1/CASP3/CREBBP/TBK1/ARAF/IFNAR1/MYC/IFNA1/NRAS/PIK3R1/PIK3CA/MAP3K7/IRF7/ATP6AP1/JAK1/FADD/NFKB1/FOS/FASLG/TP53/MAPK13/MYD88/HSPG2/BIRC5/PRKCG/MAPK1/IRAK4/IFNA5	60
KEGG	hsa04662	B cell receptor signaling pathway	35/1836	82/8135	3.645e-05	0.0006555	0.0004462	AKT2/PLCG2/BLNK/MALT1/CD72/FCGR2B/PRKCB/JUN/SYK/CD19/PIK3CB/VAV2/NFKBIE/BTK/PPP3CC/CD79B/PTPN6/NRAS/PIK3R1/PIK3CA/LILRB4/RAC2/LILRB2/VAV1/LILRB5/NFKB1/FOS/VAV3/RASGRP3/PPP3CB/CR2/INPP5D/LILRA5/MAPK1/LILRA2	35
KEGG	hsa05203	Viral carcinogenesis	71/1836	204/8135	3.729e-05	0.0006555	0.0004462	GSN/IRF9/PRKACB/CCR5/HDAC6/SCIN/POLB/CHEK1/HDAC3/GTF2E1/CCNA2/VDAC3/CCNE2/TRAF1/IL6ST/PXN/JUN/SYK/CDK1/HPN/HLA-F/NFKB2/JAK3/CDC20/RBPJL/GTF2E2/PIK3CB/YWHAZ/YWHAH/SRF/TRAF3/HDAC7/STAT5A/KAT2B/CDKN1A/CCNE1/CASP3/CREBBP/CHD4/HLA-C/CCND3/TRAF5/REL/BAK1/GTF2H1/NRAS/PIK3R1/PIK3CA/HLA-G/IRF7/HNRNPK/JAK1/NFKB1/PRKACA/HLA-A/CDKN1B/TP53/CDKN2B/HDAC1/TRADD/VAC14/RBL1/LTBR/GTF2B/RBPJ/GTF2H4/PRKACG/MAPK1/EIF2AK2/TBP/HDAC11	71
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	68/1836	194/8135	4.192e-05	7e-04	0.0004765	MICB/AKT2/PLCG2/IRF9/JAK2/FAS/MAP2K7/CCR5/STAT1/MAPK14/MAPK9/LEF1/TLR3/IL6ST/E2F3/JUN/CTNNB1/SYK/HLA-F/UBC/CD86/ZFP36/PIK3CB/MAP2K4/ITPR2/TRAF3/PIK3R5/NFATC4/CDKN1A/CASP3/CREBBP/TBK1/GNG3/IFNAR1/PPP3CC/HLA-C/CSF2/MYC/ITPR1/BAK1/IFNA1/CLEC2B/NRAS/PIK3R1/PIK3CA/HLA-G/IRF7/JAK1/FADD/TNFRSF1A/NFKB1/UBB/HLA-A/CALM1/FOS/PTGS2/TP53/MAPK13/ANGPT2/IFNAR2/TRADD/GNB3/PPP3CB/ITPR3/MAPK1/CALML3/EIF2AK2/IFNA5	68
KEGG	hsa03440	Homologous recombination	21/1836	41/8135	5.505e-05	0.000862	0.0005868	TOPBP1/ATM/RPA3/XRCC3/RAD51D/POLD3/BRCA2/TOP3A/RAD52/BLM/BARD1/RAD51B/TOP3B/BRCC3/RPA4/XRCC2/PALB2/RPA2/POLD2/NBN/BRCA1	21
KEGG	hsa05165	Human papillomavirus infection	105/1836	331/8135	5.678e-05	0.000862	0.0005868	AKT2/IRF9/PRKACB/FAS/STAT1/ATM/ATP6V1D/COL6A1/PRKCZ/ITGB4/HES1/CCNA2/PPP2CB/LLGL2/CCNE2/TLR3/ATP6V0E1/PXN/FZD2/CTNNB1/ITGA7/ITGA4/TUBG1/ATP6V1H/HLA-F/WNT7A/FZD3/MX1/TNXB/RBPJL/PIK3CB/WNT5A/TERT/EGFR/MFNG/ATP6V1A/TRAF3/HEYL/LAMC3/MX2/CDKN1A/MPP5/CCNE1/CASP3/CREBBP/TBK1/PPP2R1A/CHD4/IFNAR1/HLA-C/CCND3/RHEB/ITGB3/BAK1/ATP6V1E1/PPP2R5C/FN1/IFNA1/NRAS/PIK3R1/PIK3CA/HLA-G/ITGB7/COL4A3/WNT6/LFNG/ATP6AP1/JAK1/FADD/ATR/TNFRSF1A/NFKB1/PRKACA/PARD3/HLA-A/MAGI1/CDKN1B/PTGS2/FASLG/TP53/HDAC1/TCIRG1/PSEN1/MAML1/IFNAR2/THBS2/TRADD/LAMA2/DVL1/PPP2CA/RBL1/IRF1/WNT11/HES2/RBPJ/PRKACG/MAPK1/EIF2AK2/TBP/SPP1/FZD6/MAML3/WNT8B/IFNA5/FZD1	105
KEGG	hsa04630	JAK-STAT signaling pathway	58/1836	162/8135	7.702e-05	0.001089	0.0007413	AKT2/IRF9/JAK2/IL15/BCL2L1/SOCS3/IL15RA/STAT1/IL27RA/IL21R/IL2RG/CTF1/OSM/IL6ST/IL13/CSF2RB/STAT4/EPOR/IL2RB/JAK3/PIK3CB/LIF/IL10RA/EGFR/IL10RB/STAT5A/CDKN1A/IL7/STAT6/CREBBP/IL7R/IL5/IFNAR1/CSH1/CSF2/MYC/CCND3/MCL1/STAM2/IFNA1/PTPN6/PIK3R1/PIK3CA/IFNGR2/IFNG/PTPN2/JAK1/EPO/PIAS4/CNTFR/IFNAR2/IL11/IL2RA/SOCS2/IL10/PDGFA/IFNA5/CSF3	58
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	49/1836	131/8135	7.825e-05	0.001089	0.0007413	MICB/PLCG2/FAS/TNFSF10/LCK/PRKCB/PRF1/SYK/ITGB2/SH2D1A/CD48/CD247/TNFRSF10B/PIK3CB/ICAM2/VAV2/CASP3/ARAF/IFNAR1/PPP3CC/HLA-C/CSF2/KLRD1/IFNA1/PTPN6/NRAS/PIK3R1/PIK3CA/HLA-G/RAC2/IFNGR2/LAT/VAV1/IFNG/HLA-A/GZMB/FASLG/ITGAL/VAV3/IFNAR2/KIR2DS3/PPP3CB/PRKCG/PAK1/MAPK1/NCR2/SHC1/NCR1/IFNA5	49
KEGG	hsa04210	Apoptosis	50/1836	136/8135	0.0001104	0.001467	0.0009988	AKT2/FAS/BCL2L1/TNFSF10/ATM/MAPK9/BIRC3/GADD45B/PARP1/CTSW/PARP2/TRAF1/JUN/CSF2RB/PRF1/CTSC/NTRK1/PARP4/TNFRSF10B/PIK3CB/ITPR2/CASP3/CTSH/ITPR1/MCL1/BAK1/TUBA8/NRAS/PIK3R1/PIK3CA/CTSO/FADD/TNFRSF1A/NFKB1/TUBA1A/GZMB/FOS/FASLG/HRK/TP53/TRADD/MAP3K5/DIABLO/PIDD1/BIRC5/ITPR3/TUBA1B/MAPK1/ERN1/XIAP	50
KEGG	hsa05160	Hepatitis C	56/1836	157/8135	0.0001142	0.001467	0.0009988	CXCL10/AKT2/IRF9/FAS/SOCS3/STAT1/OAS2/PPP2CB/LDLR/TLR3/E2F3/CTNNB1/TRAF6/MX1/PIK3CB/YWHAZ/DDX58/YWHAH/EGFR/TRAF3/MX2/CDKN1A/CASP3/TBK1/RNASEL/PPP2R1A/OAS1/ARAF/IFNAR1/MYC/NR1H3/BAK1/IFNA1/NRAS/PIK3R1/PIK3CA/CLDN11/EIF3E/IRF7/IFNG/JAK1/FADD/TNFRSF1A/NFKB1/IFIT1/OAS3/EIF2AK1/FASLG/TP53/IFNAR2/TRADD/PPP2CA/MAPK1/EIF2AK2/RXRA/IFNA5	56
KEGG	hsa04620	Toll-like receptor signaling pathway	40/1836	104/8135	0.0001738	0.00215	0.001463	CXCL10/AKT2/CXCL9/MAP2K7/STAT1/CCL5/MAPK14/MAPK9/CXCL11/TAB2/TLR3/JUN/TRAF6/TLR8/CD86/PIK3CB/MAP2K4/CD40/TRAF3/TLR7/TBK1/IFNAR1/IFNA1/PIK3R1/PIK3CA/MAP3K7/CD80/IRF7/LY96/FADD/NFKB1/CD14/FOS/MAPK13/IFNAR2/MYD88/MAPK1/IRAK4/SPP1/IFNA5	40
KEGG	hsa04668	TNF signaling pathway	42/1836	112/8135	0.0002322	0.002595	0.001767	CXCL10/AKT2/FAS/IL15/MAP2K7/SOCS3/JUNB/CCL5/MAPK14/MAPK9/BIRC3/TAB2/TRAF1/JUN/MMP14/PIK3CB/LIF/MAP2K4/TRAF3/TNFRSF1B/CASP3/NOD2/CSF2/CSF1/TRAF5/RPS6KA5/PIK3R1/PIK3CA/MAP3K7/FADD/TNFRSF1A/NFKB1/FOS/PTGS2/CXCL6/MAPK13/TRADD/CEBPB/MAP3K5/RPS6KA4/IRF1/MAPK1	42
KEGG	hsa05145	Toxoplasmosis	42/1836	112/8135	0.0002322	0.002595	0.001767	AKT2/JAK2/BCL2L1/CCR5/STAT1/MAPK14/MAPK9/BIRC3/GNAI3/TAB2/LDLR/HLA-DOB/TRAF6/IL10RA/HLA-DMB/CD40/IL10RB/TGFB2/PIK3R5/LAMC3/CASP3/HLA-DPA1/CD40LG/HLA-DPB1/MAP3K7/IFNGR2/HLA-DMA/IFNG/LY96/JAK1/HSPA1L/TNFRSF1A/NFKB1/MAPK13/PPIF/MYD88/LAMA2/HLA-DRA/IL10/MAPK1/IRAK4/XIAP	42
KEGG	hsa05417	Lipid and atherosclerosis	71/1836	215/8135	0.0002397	0.002595	0.001767	AKT2/JAK2/FAS/BCL2L1/APOA1/MAP2K7/TNFSF10/CCL5/MAPK14/MAPK9/RXRB/TAB2/LDLR/CASP1/ABCG1/JUN/TRAF6/NCF1/HSP90AA1/TNFRSF10B/PIK3CB/MAP2K4/CD40/VAV2/TRAF3/CASP3/TBK1/MMP1/PPP3CC/ITPR1/CD40LG/IFNA1/NRAS/PIK3R1/PIK3CA/NOX1/IL18/MAP3K7/NCF4/IRF7/POU2F3/VAV1/LY96/HSPA1L/TNFRSF1A/NFKB1/CYBA/CD14/CALM1/RXRG/FOS/FASLG/TP53/MAPK13/VAV3/MYD88/XBP1/MAP3K5/CAMK2B/PPP3CB/APOA4/CYP2C9/CYBB/MAPK1/CALML3/RXRA/IRAK4/PYCARD/IFNA5/PPARG/ERN1	71
KEGG	hsa04935	Growth hormone synthesis, secretion and action	44/1836	119/8135	0.0002409	0.002595	0.001767	AKT2/PLCG2/JAK2/PRKACB/SOCS3/JUNB/STAT1/MAPK14/MAPK9/GNAI3/PRKCB/ADCY7/ADCY6/GNA11/PIK3CB/MAP2K4/ITPR2/SSTR3/STAT5A/CREBBP/CSH1/ITPR1/IGFALS/SSTR1/NRAS/PIK3R1/PIK3CA/CACNA1S/IRS2/ADCY8/GHSR/PRKACA/FOS/MAPK13/SSTR2/GHRH/SOCS2/PRKCG/ITPR3/PRKACG/MAPK1/SSTR5/SHC1/ADCY1	44
KEGG	hsa03030	DNA replication	18/1836	36/8135	0.0002766	0.002887	0.001966	RFC4/PCNA/RPA3/RNASEH2A/MCM5/RFC1/POLD3/RFC3/POLA1/MCM2/MCM3/MCM6/FEN1/RFC5/RPA4/RNASEH2B/RPA2/POLD2	18
KEGG	hsa05222	Small cell lung cancer	35/1836	92/8135	0.000549	0.005556	0.003782	AKT2/BCL2L1/BIRC3/RXRB/GADD45B/CCNE2/TRAF1/E2F3/TRAF6/DDB2/PIK3CB/TRAF3/LAMC3/CDKN1A/CCNE1/CASP3/MYC/TRAF5/CKS2/BAK1/ZBTB17/FN1/PIK3R1/PIK3CA/COL4A3/NFKB1/MAX/RXRG/CDKN1B/PTGS2/TP53/CDKN2B/LAMA2/RXRA/XIAP	35
KEGG	hsa05320	Autoimmune thyroid disease	23/1836	53/8135	0.0005791	0.00568	0.003867	FAS/HLA-DOB/PRF1/HLA-F/CD86/CTLA4/HLA-DMB/CD40/IL5/HLA-C/HLA-DPA1/CD40LG/IFNA1/HLA-DPB1/HLA-G/CD80/HLA-DMA/HLA-A/GZMB/FASLG/HLA-DRA/IL10/IFNA5	23
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	39/1836	106/8135	0.0005952	0.00568	0.003867	PRKACB/FGFR1/GNAI3/RXRB/EGR1/LRP6/PRKCB/ADCY7/ADCY6/GNA11/MMP14/RUNX2/ITPR2/EGFR/CDKN1A/CYP24A1/ARAF/ITPR1/NR4A2/MMP13/ADCY8/PRKACA/PDE4B/TNFSF11/RXRG/NACA/TRPV5/FOS/AKAP13/HBEGF/PTH1R/JUND/PRKCG/ITPR3/PRKACG/MAPK1/RXRA/MEF2D/ADCY1	39
KEGG	hsa05340	Primary immunodeficiency	18/1836	38/8135	0.0006405	0.005943	0.004045	RFX5/TAP1/BLNK/IL2RG/PTPRC/LCK/CD3E/CD8A/CD3D/JAK3/AIRE/CD19/CD40/BTK/IL7R/CD40LG/RFXANK/ADA	18
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	36/1836	97/8135	0.0007903	0.007135	0.004857	GSN/AKT2/PLCG2/SCIN/PIP5K1A/PTPRC/FCGR2B/PRKCB/ACTR2/PIP5K1B/SYK/ARPC5/NCF1/PLA2G4A/PIK3CB/VAV2/BIN1/ASAP1/PLA2G4C/PIK3R1/PIK3CA/PLA2G6/RAC2/LAT/MARCKSL1/VAV1/PRKCE/PRKCD/MARCKS/ACTR3/VAV3/ARF6/PRKCG/INPP5D/PAK1/MAPK1	36
KEGG	hsa04657	IL-17 signaling pathway	35/1836	94/8135	0.0008679	0.007629	0.005193	CXCL10/MAPK14/MAPK9/TAB2/IL13/JUN/TRAF6/HSP90AA1/MAPK4/IL17B/TRAF3/FOSB/CASP3/TBK1/MUC5AC/MMP1/IL5/CSF2/TRAF5/IL17RC/MAP3K7/IFNG/MMP13/FADD/NFKB1/FOS/PTGS2/CXCL6/MAPK13/TRADD/JUND/CEBPB/CCL7/MAPK1/CSF3	35
KEGG	hsa05171	Coronavirus disease - COVID-19	73/1836	232/8135	0.000959	0.008205	0.005586	CXCL10/PLCG2/IRF9/IFIH1/STAT1/MAPK14/MAPK9/RPL37A/OAS2/TAB2/PRKCB/TLR3/IL6ST/CASP1/JUN/TRAF6/RPS23/RPL9/TLR8/C7/SYK/MX1/RPL35A/PIK3CB/RPL41/C8G/DDX58/EGFR/TRAF3/TLR7/MX2/MASP1/TBK1/OAS1/MMP1/IFNAR1/RPS5/CSF2/IFNA1/PIK3R1/PIK3CA/MAP3K7/RPS4Y1/RPL39/ADAR/JAK1/RPL7/TNFRSF1A/NFKB1/TMPRSS2/RPS28/RPL18/OAS3/RPS6/RPL34/FOS/MAPK13/HBEGF/IFNAR2/MYD88/FGG/CFB/PRKCG/CYBB/MAPK1/EIF2AK2/C6/IRAK4/RPS21/IFNA5/CSF3/RPL30/RPS9	73
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	36/1836	98/8135	0.0009827	0.008205	0.005586	PLCG2/PRKACB/MAPK14/MAPK9/IL1R1/TRPV2/PRKCB/ADCY7/PRKCQ/ADCY6/PRKCH/NTRK1/PLA2G4A/PIK3CB/PPP1CA/ITPR2/ITPR1/PLA2G4C/PIK3R1/PIK3CA/PLA2G6/P2RY2/PRKCE/PRKCD/ADCY8/PRKACA/CALM1/MAPK13/CAMK2B/ASIC1/PRKCG/HRH1/ITPR3/PRKACG/CALML3/ADCY1	36
KEGG	hsa04621	NOD-like receptor signaling pathway	60/1836	184/8135	0.001007	0.008205	0.005586	GABARAPL1/AIM2/IRF9/GBP2/BCL2L1/MFN2/GBP1/STAT1/RIPK2/CCL5/MAPK14/MAPK9/BIRC3/OAS2/TAB2/VDAC3/TRPV2/CASP1/JUN/TRAF6/HSP90AA1/RBCK1/ITPR2/GSDMD/TRAF3/TBK1/RNASEL/OAS1/IFNAR1/NOD2/DEFA6/TRAF5/ITPR1/IFNA1/IL18/MAP3K7/TXN2/BRCC3/IRF7/CAMP/MFN1/PRKCD/JAK1/FADD/NFKB1/CYBA/OAS3/PSTPIP1/MAPK13/IFNAR2/NLRX1/MYD88/ATG5/ITPR3/CYBB/MAPK1/IRAK4/PYCARD/IFNA5/XIAP	60
KEGG	hsa05135	Yersinia infection	47/1836	137/8135	0.001045	0.008312	0.005658	AKT2/SKAP2/MAP2K7/MAPK14/MAPK9/PIP5K1A/TAB2/LCK/ELMO1/CD8A/CASP1/ACTR2/PXN/JUN/PIP5K1B/TRAF6/ITGA4/ARPC5/RPS6KA1/GIT2/BAIAP2/PIK3CB/MAP2K4/VAV2/WASL/TBK1/FN1/PIK3R1/PIK3CA/IL18/MAP3K7/RAC2/LAT/VAV1/NFKB1/ACTR3/FOS/MAPK13/VAV3/MYD88/ARF6/ROCK1/IL10/WIPF1/MAPK1/IRAK4/PYCARD	47
KEGG	hsa05226	Gastric cancer	50/1836	149/8135	0.001282	0.009547	0.006499	AKT2/MLH1/TGFBR2/RXRB/GADD45B/LEF1/CCNE2/LRP6/E2F3/FZD2/CTNNB1/FGF21/WNT7A/FZD3/DDB2/PIK3CB/WNT5A/SHH/TERT/EGFR/FRAT1/TGFB2/CDKN1A/CCNE1/ARAF/MYC/MUC2/BAK1/NRAS/PIK3R1/PIK3CA/CTNNA1/ABCB1/WNT6/FGF17/SMAD2/RXRG/CDKN1B/TP53/CDKN2B/FGF5/DVL1/FGF3/WNT11/MAPK1/RXRA/FZD6/WNT8B/SHC1/FZD1	50
KEGG	hsa04114	Oocyte meiosis	45/1836	131/8135	0.001283	0.009547	0.006499	PRKACB/PTTG1/MAPK14/MAD2L1/CCNB1/PPP2CB/CCNE2/FBXW11/RBX1/ADCY7/ADCY6/CDK1/SMC1A/CCNB2/RPS6KA1/AR/CDC20/CDC16/YWHAZ/PPP1CA/ITPR2/YWHAH/AURKA/CCNE1/PPP2R1A/PPP3CC/SPDYE2/ITPR1/PPP2R5C/CPEB3/BUB1/ADCY8/PRKACA/CALM1/MAPK13/PPP2CA/CAMK2B/PPP3CB/ITPR3/PRKACG/MAPK1/CALML3/CDC23/FBXO5/ADCY1	45
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	33/1836	89/8135	0.001308	0.009547	0.006499	AKT2/JAK2/STAT1/MAPK14/LCK/CD3E/RASGRP1/PRKCQ/CD3D/JUN/TRAF6/CD3G/CD247/PIK3CB/ALK/NFKBIE/EGFR/PPP3CC/PTPN6/NRAS/PIK3R1/PIK3CA/IFNGR2/LAT/IFNG/JAK1/NFKB1/FOS/MAPK13/MYD88/PPP3CB/MAPK1/BATF	33
KEGG	hsa04940	Type I diabetes mellitus	19/1836	43/8135	0.001315	0.009547	0.006499	FAS/HLA-DOB/PRF1/HLA-F/CD86/HLA-DMB/HLA-C/HLA-DPA1/HLA-DPB1/HLA-G/CD80/HLA-DMA/IFNG/HLA-A/GAD2/GZMB/FASLG/HLA-DRA/PTPRN	19
KEGG	hsa05216	Thyroid cancer	17/1836	37/8135	0.001381	0.009812	0.006679	RXRB/GADD45B/LEF1/TPR/CTNNB1/NTRK1/DDB2/CDKN1A/MYC/BAK1/NRAS/TPM3/RXRG/TP53/MAPK1/RXRA/PPARG	17
KEGG	hsa05205	Proteoglycans in cancer	65/1836	205/8135	0.001434	0.009975	0.00679	AKT2/PLCG2/PRKACB/FAS/FGFR1/MAPK14/EZR/PPP1R12A/SDC1/PRKCB/GPC1/PXN/FZD2/CTNNB1/FLNB/WNT7A/FZD3/TIMP3/PIK3CB/FRS2/WNT5A/SHH/PPP1CA/ITPR2/VAV2/EGFR/TGFB2/CDKN1A/CASP3/ARAF/MYC/ITPR1/ITGB3/IHH/FN1/DROSHA/PTPN6/NRAS/PIK3R1/PIK3CA/WNT6/VAV1/SMAD2/PRKACA/IQGAP1/RPS6/FASLG/TP53/MAPK13/HBEGF/VAV3/HSPG2/RRAS/CAMK2B/ROCK1/WNT11/PRKCG/PAK1/ITPR3/PRKACG/MAPK1/FZD6/HPSE/WNT8B/FZD1	65
KEGG	hsa04912	GnRH signaling pathway	34/1836	93/8135	0.001476	0.01006	0.006848	PRKACB/MAP2K7/MAPK14/MAPK9/EGR1/PRKCB/ADCY7/JUN/ADCY6/GNA11/MMP14/PLA2G4A/MAP2K4/ITPR2/EGFR/ITPR1/PLA2G4C/NRAS/FSHB/CACNA1S/PRKCD/ADCY8/PRKACA/GNRHR/CALM1/MAPK13/GNRH2/HBEGF/CAMK2B/ITPR3/PRKACG/MAPK1/CALML3/ADCY1	34
KEGG	hsa03430	Mismatch repair	12/1836	23/8135	0.001826	0.0122	0.008302	RFC4/PCNA/MLH1/RPA3/RFC1/POLD3/RFC3/MSH2/RFC5/RPA4/RPA2/POLD2	12
KEGG	hsa04934	Cushing syndrome	51/1836	155/8135	0.001873	0.01226	0.008349	PRKACB/GNAI3/LEF1/LDLR/CCNE2/CACNA1I/ADCY7/KCNK3/E2F3/FZD2/CTNNB1/NR5A1/ADCY6/GNA11/WNT7A/FZD3/NR4A1/KCNK2/WNT5A/ITPR2/EGFR/CDKN1A/CCNE1/ITPR1/AGT/WNT6/CACNA1H/CACNA1S/WDR5B/ADCY8/CYP17A1/PRKACA/CRH/CDKN1B/CDKN2B/USP8/DVL1/CAMK2B/POMC/RBBP5/WNT11/ITPR3/KMT2A/PRKACG/MAPK1/AHR/FZD6/WNT8B/PDE8A/ADCY1/FZD1	51
KEGG	hsa05132	Salmonella infection	76/1836	249/8135	0.001961	0.0126	0.008575	AKT2/MAP2K7/EXOC2/TNFSF10/RIPK2/MAPK14/MAPK9/BIRC3/PLEKHM2/EXOC5/TAB2/ACBD3/LEF1/CYFIP2/PTPRC/ELMO1/CASP1/ABI1/ACTR2/JUN/CYTH3/CTNNB1/TRAF6/ACTR10/ARPC5/FLNB/RHOH/PAK3/HSP90AA1/VPS41/CYTH1/TNFRSF10B/PIK3CB/MAP2K4/GCC2/GSDMD/WASL/DYNLT1/ANXA2/RHOB/CASP3/MYC/MYL5/BAK1/TUBA8/TUBB/KLC1/PIK3CA/IL18/MAP3K7/TXN2/VPS39/DYNC1I2/LY96/FADD/TUBB2A/TNFRSF1A/NFKB1/TUBA1A/PIK3C2B/EXOC7/ACTR3/CD14/DCTN3/FOS/MAPK13/MYD88/TRADD/RRAS/ARF6/PAK1/TUBA1B/KIF5C/MAPK1/IRAK4/PYCARD	76
KEGG	hsa05202	Transcriptional misregulation in cancer	61/1836	193/8135	0.002151	0.01355	0.009227	BCL2L1/NCOR1/FUT8/ATM/TAF15/TGFBR2/BIRC3/RXRB/SS18/FUS/GADD45B/HHEX/CCNA2/TRAF1/CDK9/FLI1/MLLT1/HOXA11/CCNT1/IL2RB/CD86/NTRK1/DDB2/CSF1R/ID2/TFE3/RUNX2/CD40/MLLT3/BAIAP3/CDKN1A/BCL11B/CSF2/MYC/ELANE/DEFA6/REL/PTCRA/BAK1/ZBTB17/NR4A3/ITGB7/BCL6/NFKB1/TMPRSS2/MAX/CD14/RXRG/GZMB/CDKN1B/TP53/ASPSCR1/HDAC1/CCNT2/CEBPB/ZBTB16/KMT2A/RARA/RXRA/PDGFA/PPARG	61
KEGG	hsa05142	Chagas disease	36/1836	102/8135	0.002222	0.01374	0.009355	AKT2/FAS/CCL5/MAPK14/MAPK9/TGFBR2/GNAI3/PPP2CB/CD3E/CD3D/JUN/TRAF6/CD3G/GNA11/CD247/PIK3CB/MAP2K4/TGFB2/PPP2R1A/PIK3R1/PIK3CA/IFNGR2/IFNG/FADD/TNFRSF1A/NFKB1/SMAD2/FOS/FASLG/MAPK13/MYD88/PPP2CA/IL10/MAPK1/IRAK4/ADCY1	36
KEGG	hsa05332	Graft-versus-host disease	18/1836	42/8135	0.002652	0.0161	0.01096	FAS/HLA-DOB/PRF1/HLA-F/CD86/HLA-DMB/HLA-C/HLA-DPA1/KLRD1/HLA-DPB1/HLA-G/CD80/HLA-DMA/IFNG/HLA-A/GZMB/FASLG/HLA-DRA	18
KEGG	hsa05163	Human cytomegalovirus infection	69/1836	225/8135	0.002713	0.01618	0.01101	AKT2/PRKACB/FAS/TAP1/CCR5/CCL5/MAPK14/GNAI3/IL1R1/PTGER1/PRKCB/ADCY7/PXN/E2F3/CTNNB1/ADCY6/GNA11/HLA-F/TAPBP/PIK3CB/IL10RA/CXCR4/ITPR2/EGFR/IL10RB/NFATC4/CDKN1A/CASP3/TBK1/GNG3/PPP3CC/HLA-C/MYC/TRAF5/ITPR1/RHEB/ITGB3/BAK1/IFNA1/NRAS/PIK3R1/PIK3CA/HLA-G/RAC2/JAK1/FADD/TNFRSF1A/NFKB1/ADCY8/PRKACA/HLA-A/CALM1/PTGS2/FASLG/TP53/MAPK13/AKAP13/TRADD/ROCK1/GNB3/PPP3CB/PRKCG/ITPR3/PRKACG/MAPK1/CALML3/B2M/IFNA5/ADCY1	69
KEGG	hsa05152	Tuberculosis	57/1836	180/8135	0.002816	0.0165	0.01123	AKT2/JAK2/RFX5/STAT1/RIPK2/MAPK14/MAPK9/MALT1/FCGR2B/HLA-DOB/TRAF6/SYK/ATP6V1H/ITGB2/IL10RA/HLA-DMB/IL10RB/TGFB2/CASP3/CREBBP/NOD2/PPP3CC/HLA-DPA1/CORO1A/IFNA1/CR1/RFXANK/HLA-DPB1/IL18/IFNGR2/HLA-DMA/CAMP/IFNG/ATP6AP1/JAK1/FADD/TNFRSF1A/LAMP1/NFKB1/CD14/CALM1/PLK3/CD74/MAPK13/TCIRG1/MYD88/TRADD/CEBPB/HLA-DRA/CAMK2B/NFYB/PPP3CB/IL10/MAPK1/CALML3/IRAK4/IFNA5	57
KEGG	hsa04062	Chemokine signaling pathway	60/1836	192/8135	0.003111	0.01791	0.01219	CXCL10/AKT2/PLCG2/CXCL9/JAK2/PRKACB/CXCL13/CCR5/STAT1/CCL18/CCL5/GNAI3/CXCL11/PRKCZ/ELMO1/PRKCB/XCL1/ADCY7/PXN/ADCY6/CCR2/NCF1/ITK/JAK3/GRK1/PIK3CB/CXCR4/VAV2/PIK3R5/GNG3/CCL13/CCR7/DOCK2/NRAS/PIK3R1/PIK3CA/RAC2/VAV1/PRKCD/NFKB1/ADCY8/PRKACA/GRK6/PARD3/CCL19/CXCL6/CCL1/VAV3/FOXO3/CCL21/ROCK1/CCL7/GNB3/PAK1/GSK3A/PRKACG/MAPK1/SHC1/FGR/ADCY1	60
KEGG	hsa04920	Adipocytokine signaling pathway	26/1836	69/8135	0.003164	0.01791	0.01219	AKT2/JAK2/SOCS3/MAPK9/ACSL5/RXRB/AGRP/PRKCQ/STK11/NFKBIE/ACSL6/TNFRSF1B/ADIPOR1/G6PC3/ACACB/IRS2/TNFRSF1A/NFKB1/ACSL3/RXRG/PRKAA2/TRADD/PRKAB2/POMC/SLC2A4/RXRA	26
KEGG	hsa04722	Neurotrophin signaling pathway	40/1836	119/8135	0.003614	0.02012	0.0137	AKT2/PLCG2/MAP2K7/RIPK2/MAPK14/MAPK9/RAPGEF1/JUN/TRAF6/NTRK2/RPS6KA1/NTRK1/PIK3CB/FRS2/NFKBIE/ZNF274/RPS6KA5/ARHGDIB/NRAS/PIK3R1/PIK3CA/PRKCD/NFKB1/CALM1/FASLG/TP53/MAPK13/PSEN1/ARHGDIA/FOXO3/SORT1/MAP3K5/CAMK2B/SH2B3/SH2B1/MAPK1/CALML3/IRAK4/BDNF/SHC1	40
KEGG	hsa04270	Vascular smooth muscle contraction	44/1836	134/8135	0.003869	0.02118	0.01442	PRKACB/PPP1R12A/KCNMB1/PRKCB/ADCY7/PLA2G2D/PRKCQ/ADCY6/GNA11/PRKCH/MYL6/PLA2G4A/PPP1CA/ITPR2/ADM2/ARAF/AVP/ITPR1/AGT/EDN2/PLA2G2E/PLA2G4C/PLA2G6/CACNA1S/PRKCE/PRKCD/CALCA/NPPB/PRKG1/ADCY8/PRKACA/CALM1/ROCK1/MYH14/PLA2G12A/CALD1/PRKCG/KCNMB4/ITPR3/PRKACG/MAPK1/CALML3/ADM/ADCY1	44
KEGG	hsa05416	Viral myocarditis	23/1836	60/8135	0.004166	0.02244	0.01528	EIF4G1/HLA-DOB/SGCA/PRF1/HLA-F/ITGB2/CD86/HLA-DMB/CD40/CASP3/HLA-C/HLA-DPA1/CD40LG/HLA-DPB1/HLA-G/RAC2/CD80/HLA-DMA/HLA-A/ITGAL/LAMA2/HLA-DRA/DAG1	23
KEGG	hsa04060	Cytokine-cytokine receptor interaction	86/1836	295/8135	0.004403	0.02334	0.01589	CXCL10/CXCL9/CXCL13/FAS/IL15/IL15RA/CCR5/TNFSF10/IL32/CCL18/CLCF1/CCL5/IL27RA/TGFBR2/IL21R/CD27/CXCL11/IL2RG/CTF1/IL1R1/OSM/TNFRSF17/XCL1/IL6ST/IL13/CSF2RB/IL16/IL1RL2/EPOR/ACVRL1/CCR2/IL2RB/CD70/GDF5/TNFRSF10D/CSF1R/TNFRSF10B/LIF/IL17B/IL10RA/TNFSF4/CXCR4/CD40/IL10RB/TGFB2/IL7/TNFRSF1B/IL7R/IL5/IFNAR1/CCL13/CSH1/CSF2/CCR7/CSF1/AMHR2/CD40LG/IFNA1/IL17RC/IL18/IFNGR2/IFNG/GDF15/TNFRSF1A/LTB/IL36G/TNFSF11/CCL19/EPO/FASLG/CNTFR/CXCL6/CCL1/BMP10/BMP8A/IFNAR2/CCL21/IL11/IL2RA/LTBR/CCL7/GDF2/IL10/INHBA/IFNA5/CSF3	86
KEGG	hsa04611	Platelet activation	41/1836	124/8135	0.004517	0.02357	0.01605	AKT2/PLCG2/PRKACB/MAPK14/GNAI3/PRKCZ/PPP1R12A/ADCY7/RASGRP1/VAMP8/ADCY6/SYK/APBB1IP/PLA2G4A/PIK3CB/PPP1CA/ITPR2/BTK/PIK3R5/ITPR1/ITGB3/PLA2G4C/ARHGAP35/PIK3R1/PIK3CA/F2R/PRKG1/ADCY8/PRKACA/GP9/MAPK13/FGG/TLN2/ROCK1/COL3A1/P2RX1/ITPR3/PRKACG/MAPK1/SNAP23/ADCY1	41
KEGG	hsa04919	Thyroid hormone signaling pathway	40/1836	121/8135	0.005015	0.02577	0.01754	AKT2/PLCG2/PRKACB/NCOR1/STAT1/HDAC3/DIO3/RXRB/PRKCB/CTNNB1/PIK3CB/MED12/DIO2/KAT2B/CREBBP/MYC/RHEB/ITGB3/MED13L/NRAS/PIK3R1/PIK3CA/ATP2A3/PRKACA/ATP1B3/RXRG/PLCD1/MED17/TP53/TBC1D4/HDAC1/THRA/ATP1B2/PRKCG/ATP2A1/NCOA1/PRKACG/MAPK1/RXRA/MED14	40
KEGG	hsa04216	Ferroptosis	17/1836	41/8135	0.0052	0.02612	0.01778	ACSL5/SLC3A2/VDAC3/SAT1/FTL/ACSL6/SLC39A8/ACSL3/STEAP3/GPX4/TP53/GSS/TFRC/ATG5/CYBB/HMOX1/ATG7	17
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	131/1836	476/8135	0.00524	0.02612	0.01778	FAS/BCL2L1/MFN2/RAB8A/FIG4/MAP2K7/UBE2J1/HAP1/MAPK14/MAPK9/UBE2L6/NDUFA9/GRIN2C/SPG11/FUS/VDAC3/LRP6/PRKCB/UBE2G2/FZD2/ATG2B/CTNNB1/OPTN/NDUFS3/CACNA1B/RYR1/ACTR10/WNT7A/FZD3/UBC/PSMC2/NDUFS1/SNCA/APP/WNT5A/DNAL4/UBE2G1/PSMD3/TOMM40/ITPR2/PPID/SQSTM1/FRAT1/TNFRSF1B/CASP3/TBK1/UBE2L3/NDUFS7/ARAF/PPP3CC/CDK5/CSF1/DNAH9/PSMA5/ITPR1/BAK1/TUBA8/TUBB/MAP3K10/KLC1/NRAS/NOX1/PSMD8/WNT6/DNAH17/PSMB5/CACNA1S/MFN1/GPX3/PSMB2/SLC6A3/ATG13/ATXN3/PSMA4/WIPI1/FADD/ATP2A3/HIP1/TUBB2A/TNFRSF1A/NFKB1/SDHA/TUBA1A/NDUFA8/UBB/DCTN3/STX1A/CALM1/PTGS2/FASLG/TRAP1/UCHL1/MAPK13/ATXN2L/PPIF/PSEN1/XBP1/PSMA2/DVL1/SLC25A31/PSMD4/MAP3K5/DKK2/CAMK2B/NDUFB3/COX6A2/ULK1/WNT11/PPP3CB/PRKCG/PSMB7/PSMB4/ATP2A1/ITPR3/TUBA1B/CYBB/KIF5C/MAPT/NOX4/MAPK1/CALML3/NDUFB5/UQCRC1/BDNF/FZD6/SLC25A4/WNT8B/DNAH6/DKK4/ERN1/FZD1	131
KEGG	hsa04664	Fc epsilon RI signaling pathway	25/1836	68/8135	0.005463	0.02684	0.01827	AKT2/PLCG2/MAP2K7/MAPK14/MAPK9/IL13/SYK/PLA2G4A/PIK3CB/MAP2K4/VAV2/BTK/IL5/CSF2/PLA2G4C/NRAS/PIK3R1/PIK3CA/RAC2/LAT/VAV1/MAPK13/VAV3/INPP5D/MAPK1	25
KEGG	hsa05323	Rheumatoid arthritis	32/1836	93/8135	0.005886	0.02849	0.01939	IL15/CCL5/ATP6V1D/HLA-DOB/ATP6V0E1/JUN/ATP6V1H/ITGB2/CD86/CTLA4/HLA-DMB/ATP6V1A/TGFB2/MMP1/CSF2/HLA-DPA1/CSF1/ATP6V1E1/HLA-DPB1/IL18/CD80/HLA-DMA/IFNG/ATP6AP1/LTB/TNFSF11/FOS/CXCL6/ITGAL/TCIRG1/IL11/HLA-DRA	32
KEGG	hsa05210	Colorectal cancer	30/1836	86/8135	0.006027	0.02869	0.01953	AKT2/MLH1/MAPK9/TGFBR2/GADD45B/LEF1/JUN/CTNNB1/MSH2/DDB2/PIK3CB/EGFR/TGFB2/CDKN1A/CASP3/ARAF/MYC/BAK1/NRAS/PIK3R1/PIK3CA/RAC2/SMAD2/FOS/TP53/APPL1/EREG/BIRC5/AREG/MAPK1	30
KEGG	hsa04625	C-type lectin receptor signaling pathway	35/1836	104/8135	0.006098	0.02869	0.01953	AKT2/PLCG2/IRF9/STAT1/MAPK14/MAPK9/MALT1/CASP1/JUN/SYK/NFKB2/PIK3CB/ITPR2/NFATC4/PPP3CC/ITPR1/NRAS/PIK3R1/PIK3CA/PRKCD/NFKB1/RELB/CALM1/PLK3/PTGS2/MAPK13/RRAS/IRF1/PPP3CB/PAK1/ITPR3/IL10/MAPK1/CALML3/PYCARD	35
KEGG	hsa01524	Platinum drug resistance	26/1836	73/8135	0.007509	0.03483	0.02371	AKT2/FAS/BCL2L1/MLH1/ATM/BIRC3/MSH2/PIK3CB/CDKN1A/CASP3/TOP2A/BAK1/PIK3R1/PIK3CA/FADD/REV3L/FASLG/TP53/MAP3K5/BIRC5/XPA/TOP2B/MAPK1/BRCA1/SLC31A1/XIAP	26
KEGG	hsa04672	Intestinal immune network for IgA production	19/1836	49/8135	0.007643	0.03497	0.0238	IL15/IL15RA/HLA-DOB/TNFRSF17/ITGA4/CD86/HLA-DMB/CXCR4/CD40/IL5/HLA-DPA1/CD40LG/HLA-DPB1/ITGB7/CD80/HLA-DMA/HLA-DRA/LTBR/IL10	19
KEGG	hsa03250	Viral life cycle - HIV-1	23/1836	63/8135	0.008282	0.03719	0.02531	CCR5/XPO1/TSG101/CDK9/MLLT1/APOBEC3G/APOBEC3B/CCNT1/PSIP1/MX1/APOBEC3C/CXCR4/MLLT3/KAT2B/MX2/CREBBP/SERINC3/FURIN/TRIM5/PDCD6IP/CCNT2/SUPT4H1/NELFB	23
KEGG	hsa04930	Type II diabetes mellitus	18/1836	46/8135	0.00835	0.03719	0.02531	SOCS3/MAPK9/PRKCZ/CACNA1B/PIK3CB/PIK3R1/PIK3CA/CACNA1E/PRKCE/PRKCD/IRS2/GCK/SLC2A2/PDX1/SOCS2/SLC2A4/ABCC8/MAPK1	18
KEGG	hsa04012	ErbB signaling pathway	29/1836	85/8135	0.009661	0.04246	0.0289	AKT2/PLCG2/MAP2K7/MAPK9/PAK2/PRKCB/JUN/NCK1/PAK3/PIK3CB/MAP2K4/EGFR/STAT5A/CDKN1A/ARAF/MYC/NRAS/PIK3R1/PIK3CA/CDKN1B/EREG/HBEGF/BTC/CAMK2B/PRKCG/PAK1/AREG/MAPK1/SHC1	29
KEGG	hsa04310	Wnt signaling pathway	51/1836	167/8135	0.009897	0.04293	0.02923	PRKACB/MAPK9/TBL1X/LEF1/SFRP1/LRP6/PRKCB/FBXW11/RBX1/JUN/FZD2/CTNNB1/TBL1XR1/WNT7A/FZD3/VANGL1/WNT5A/FRAT1/NFATC4/CREBBP/PPP3CC/MYC/CCND3/CACYBP/RNF43/MAP3K7/RAC2/ROR1/NLK/TLE6/WNT6/PRKACA/SFRP5/TP53/PSEN1/TLE2/CXXC4/DVL1/DKK2/CAMK2B/WNT11/PPP3CB/PRKCG/DAAM1/PRKACG/FZD6/WNT8B/PORCN/DKK4/TLE1/FZD1	51
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	33/1836	100/8135	0.01048	0.04428	0.03014	CXCL10/CXCL9/CXCL13/CCR5/TNFSF10/CCL18/CCL5/CXCL11/IL2RG/XCL1/IL6ST/CCR2/IL2RB/TNFRSF10D/CSF1R/TNFRSF10B/IL10RA/CXCR4/IL10RB/TNFRSF1B/CCL13/CCR7/CSF1/IL18/TNFRSF1A/CCL19/CXCL6/CCL1/CCL21/IL2RA/LTBR/CCL7/IL10	33
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1836	100/8135	0.01048	0.04428	0.03014	AKT2/PLCG2/JAK2/STAT1/MAPK14/MAPK9/TGFBR2/EGR1/PRKCZ/PRKCB/JUN/PIK3CB/TGFB2/STAT5A/CASP3/AGT/FN1/NRAS/PIK3R1/PIK3CA/NOX1/COL4A3/PRKCE/PRKCD/NFKB1/SMAD2/PLCD1/CDKN1B/MAPK13/COL3A1/CYBB/NOX4/MAPK1	33
KEGG	hsa04140	Autophagy - animal	44/1836	141/8135	0.01062	0.04428	0.03014	GABARAPL1/AKT2/PRKACB/BCL2L1/RAB8A/MAPK9/ATG4A/PPP2CB/MTMR4/PRKCQ/ATG2B/TRAF6/VAMP8/STK11/MTMR3/MTMR14/SH3GLB1/PIK3CB/SQSTM1/TBK1/ITPR1/RHEB/NRAS/PIK3R1/PIK3CA/MAP3K7/PRKCD/ATG13/WIPI1/IRS2/LAMP1/PRKACA/PRKAA2/PPP2CA/RRAS/ULK1/ATG5/UVRAG/ATG4B/PRKACG/MAPK1/ERN1/DAPK2/ATG7	44
KEGG	hsa03420	Nucleotide excision repair	18/1836	47/8135	0.01074	0.04428	0.03014	RFC4/PCNA/RPA3/RBX1/RFC1/POLD3/CDK7/RFC3/DDB2/GTF2H1/RFC5/RPA4/RPA2/POLD2/XPA/XPC/GTF2H4/GTF2H5	18
KEGG	hsa05223	Non-small cell lung cancer	25/1836	72/8135	0.01231	0.04983	0.03392	AKT2/PLCG2/RXRB/GADD45B/PRKCB/E2F3/JAK3/DDB2/PIK3CB/ALK/EGFR/STAT5A/CDKN1A/ARAF/BAK1/NRAS/PIK3R1/PIK3CA/RXRG/TP53/FOXO3/PRKCG/KIF5C/MAPK1/RXRA	25
KEGG	hsa04927	Cortisol synthesis and secretion	23/1836	65/8135	0.01253	0.04983	0.03392	PRKACB/LDLR/CACNA1I/ADCY7/KCNK3/NR5A1/ADCY6/GNA11/NR4A1/KCNK2/ITPR2/ITPR1/AGT/CACNA1H/CACNA1S/ADCY8/CYP17A1/PRKACA/POMC/ITPR3/PRKACG/PDE8A/ADCY1	23
KEGG	hsa05321	Inflammatory bowel disease	23/1836	65/8135	0.01253	0.04983	0.03392	STAT1/IL21R/IL2RG/HLA-DOB/IL13/JUN/STAT4/HLA-DMB/TGFB2/STAT6/IL5/NOD2/HLA-DPA1/HLA-DPB1/IL18/IFNGR2/HLA-DMA/IFNG/NFKB1/SMAD2/FOXP3/HLA-DRA/IL10	23
KEGG	hsa04144	Endocytosis	72/1836	251/8135	0.01289	0.05063	0.03447	RAB8A/ARFGEF1/CCR5/RAB35/STAMBP/TGFBR2/PIP5K1A/IL2RG/PRKCZ/VPS35/LDLR/SNX6/TSG101/ACTR2/RAB11FIP3/CYTH3/EPN1/FGFR4/PIP5K1B/TRAF6/ARPC5/ZFYVE9/HLA-F/IL2RB/GIT2/SH3GLB1/GRK1/CYTH1/RAB11A/CXCR4/EHD3/EGFR/WASL/BIN1/HLA-C/ASAP1/VPS45/STAM2/HLA-G/LDLRAP1/HSPA1L/SMAP1/AGAP2/CBLC/GIT1/SMAD2/SNX4/GRK6/PSD/ACAP1/ACTR3/PARD3/SH3GL1/HLA-A/ZFYVE16/USP8/TFRC/PDCD6IP/SH3GL3/ACAP2/IL2RA/ARF6/EPS15/CHMP7/RAB22A/KIF5C/WIPF1/EPN3/SH3GLB2/EHD4/SNF8/CLTC	72
KEGG	hsa04925	Aldosterone synthesis and secretion	32/1836	98/8135	0.01366	0.05285	0.03598	PRKACB/LDLR/PRKCB/CACNA1I/ADCY7/KCNK3/ADCY6/GNA11/PRKD2/NR4A1/ITPR2/DAGLA/ITPR1/AGT/NR4A2/LIPE/CACNA1H/CACNA1S/ATP2B4/PRKCE/ADCY8/PRKACA/ATP1B3/CALM1/CAMK2B/POMC/ATP1B2/PRKCG/ITPR3/PRKACG/CALML3/ADCY1	32
KEGG	hsa05017	Spinocerebellar ataxia	44/1836	143/8135	0.01377	0.05285	0.03598	AKT2/MAPK9/GRIN2C/VDAC3/PRKCB/ATG2B/RYR1/PUM2/PSMC2/RBPJL/PIK3CB/PSMD3/ITPR2/PSMA5/ITPR1/OPA1/PIK3R1/PIK3CA/PSMD8/PSMB5/PSMB2/ATG13/ATXN3/PSMA4/WIPI1/ATP2A3/ATXN2L/PPIF/XBP1/PSMA2/SLC25A31/PSMD4/MAP3K5/ULK1/GTF2B/PRKCG/PSMB7/PSMB4/ATP2A1/RBPJ/ITPR3/TBP/SLC25A4/ERN1	44
KEGG	hsa04115	p53 signaling pathway	25/1836	73/8135	0.0148	0.05619	0.03825	FAS/BCL2L1/ATM/CHEK1/RRM2/GADD45B/CCNB1/CCNE2/ZMAT3/CDK1/CCNB2/DDB2/TNFRSF10B/CDKN1A/CCNE1/CASP3/CCND3/ATR/RPRM/STEAP3/TP53/SERPINB5/PPM1D/PIDD1/MDM4	25
KEGG	hsa04917	Prolactin signaling pathway	24/1836	70/8135	0.01648	0.06186	0.04211	AKT2/JAK2/SOCS3/STAT1/MAPK14/MAPK9/PIK3CB/STAT5A/NRAS/PIK3R1/PIK3CA/NFKB1/GCK/CYP17A1/TH/TNFSF11/FOS/MAPK13/FOXO3/SLC2A2/SOCS2/IRF1/MAPK1/SHC1	24
KEGG	hsa03050	Proteasome	17/1836	46/8135	0.01897	0.07041	0.04793	PSMB9/PSMB8/PSMB10/PSME1/PSMC2/PSMD3/PSMA5/PSMD8/PSMB5/IFNG/PSMB2/PSMA4/PSMF1/PSMA2/PSMD4/PSMB7/PSMB4	17
KEGG	hsa04929	GnRH secretion	22/1836	64/8135	0.02047	0.07423	0.05053	AKT2/PRKCB/CACNA1I/KCNN4/GNA11/KCNN3/PIK3CB/ITPR2/KCNN2/ITPR1/NRAS/PIK3R1/PIK3CA/CACNA1H/CACNA1S/HCN2/GNRH2/TRPC4/PRKCG/ITPR3/MAPK1/SPP1	22
KEGG	hsa04070	Phosphatidylinositol signaling system	31/1836	97/8135	0.02057	0.07423	0.05053	PLCG2/PI4K2A/PIP5K1A/MTMR6/PRKCB/MTMR4/CDS2/PIP5K1B/MTMR3/MTMR14/DGKQ/PIK3CB/PPIP5K2/ITPR2/MTM1/ITPR1/PIK3R1/PIK3CA/PIP4K2C/PIK3C2B/ITPKA/CALM1/PLCD1/PI4KA/ITPKB/IP6K2/PRKCG/INPP5D/ITPR3/CALML3/DGKA	31
KEGG	hsa04068	FoxO signaling pathway	40/1836	131/8135	0.02067	0.07423	0.05053	GABARAPL1/AKT2/TNFSF10/MAPK14/ATM/MAPK9/TGFBR2/GADD45B/CCNB1/STK11/CCNB2/PIK3CB/EGFR/TGFB2/CDKN1A/CREBBP/IL7R/ARAF/NRAS/PIK3R1/PIK3CA/G6PC3/NLK/BCL6/AGAP2/PLK2/IRS2/CDKN2D/PLK3/CDKN1B/FASLG/CDKN2B/MAPK13/PRKAA2/FOXO3/PRKAB2/SLC2A4/SGK1/IL10/MAPK1	40
KEGG	hsa05130	Pathogenic Escherichia coli infection	57/1836	197/8135	0.02098	0.07455	0.05075	FAS/TNFSF10/MAPK14/MAPK9/EZR/TAB2/PAK2/IL1R1/CYFIP2/CASP1/ABI1/ACTR2/JUN/NCK1/CYTH3/TRAF6/ARPC5/PAK3/BAIAP2/CYTH1/TNFRSF10B/WASL/CASP3/SEC24A/BAK1/TUBA8/TUBB/PTPN6/CLDN11/IL18/MAP3K7/F2R/MYO1A/TMED10/MYO5A/FADD/TUBB2A/TNFRSF1A/NFKB1/TUBA1A/ACTR3/FOS/FASLG/MAPK13/MYD88/TRADD/ARF6/ROCK1/MYH14/ABCF2/PAK1/MYO1F/TUBA1B/WIPF1/MAPK1/IRAK4/PYCARD	57
KEGG	hsa04916	Melanogenesis	32/1836	101/8135	0.02138	0.07515	0.05116	PRKACB/GNAI3/LEF1/PRKCB/ADCY7/FZD2/CTNNB1/EDNRB/ADCY6/WNT7A/FZD3/WNT5A/KITLG/CREBBP/NRAS/WNT6/ADCY8/TYRP1/PRKACA/CALM1/DVL1/CAMK2B/POMC/WNT11/PRKCG/PRKACG/MAPK1/CALML3/FZD6/WNT8B/ADCY1/FZD1	32
KEGG	hsa05224	Breast cancer	44/1836	147/8135	0.02236	0.0778	0.05296	AKT2/FGFR1/GADD45B/HES1/LEF1/LRP6/E2F3/JUN/FZD2/CTNNB1/FGF21/BRCA2/WNT7A/FZD3/NFKB2/DDB2/PIK3CB/WNT5A/EGFR/FRAT1/HEYL/CDKN1A/ARAF/MYC/BAK1/NRAS/PIK3R1/PIK3CA/WNT6/FGF17/TNFSF11/FOS/TP53/FGF5/DVL1/FGF3/WNT11/NCOA1/MAPK1/FZD6/WNT8B/SHC1/BRCA1/FZD1	44
KEGG	hsa04151	PI3K-Akt signaling pathway	96/1836	354/8135	0.02285	0.07867	0.05355	AKT2/JAK2/BCL2L1/FGFR1/IL2RG/COL6A1/ITGB4/PPP2CB/CCNE2/OSM/FGFR4/ITGA7/FGF21/ITGA4/SYK/NTRK2/EPOR/STK11/NR4A1/IL2RB/NTRK1/TNXB/JAK3/HSP90AA1/CSF1R/CD19/PIK3CB/YWHAZ/YWHAH/EGFR/KITLG/PIK3R5/LAMC3/CDKN1A/IL7/CCNE1/GNG3/PPP2R1A/IL7R/IFNAR1/CSH1/MYC/CCND3/CSF1/RHEB/ITGB3/MCL1/PPP2R5C/FN1/IFNA1/NRAS/PIK3R1/PIK3CA/ITGB7/G6PC3/COL4A3/F2R/JAK1/EFNA5/FGF17/NFKB1/FLT3LG/RPS6/EPO/MAGI1/CDKN1B/FASLG/EFNA4/TP53/ANGPT2/PRKAA2/EREG/IFNAR2/THBS2/FOXO3/FGF5/LAMA2/PPP2CA/IL2RA/LPAR6/EIF4E2/FGF3/GNB3/PDGFC/AREG/SGK1/MAPK1/RXRA/BDNF/SPP1/PDGFA/BRCA1/PHLPP1/GYS1/IFNA5/CSF3	96
KEGG	hsa03460	Fanconi anemia pathway	19/1836	54/8135	0.02342	0.07983	0.05434	RMI1/FANCF/MLH1/RPA3/HES1/BRCA2/TOP3A/BLM/FANCG/TOP3B/ATR/RPA4/FANCL/FANCI/REV3L/PALB2/RPA2/POLI/BRCA1	19
KEGG	hsa04914	Progesterone-mediated oocyte maturation	32/1836	102/8135	0.0246	0.08275	0.05633	AKT2/PRKACB/MAPK14/MAPK9/GNAI3/CCNA2/MAD2L1/CCNB1/ADCY7/ADCY6/CDK1/STK10/CCNB2/RPS6KA1/HSP90AA1/CDC25B/CDC16/PIK3CB/AURKA/ARAF/SPDYE2/PIK3R1/PIK3CA/CPEB3/BUB1/ADCY8/PRKACA/MAPK13/PRKACG/MAPK1/CDC23/ADCY1	32
KEGG	hsa04971	Gastric acid secretion	25/1836	76/8135	0.02478	0.08275	0.05633	PRKACB/GNAI3/EZR/PRKCB/ADCY7/ADCY6/KCNJ2/KCNK2/ITPR2/ITPR1/ATP4A/ADCY8/PRKACA/ATP1B3/CALM1/CA2/SSTR2/CAMK2B/ATP1B2/PRKCG/HRH2/ITPR3/PRKACG/CALML3/ADCY1	25
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	11/1836	27/8135	0.02623	0.08675	0.05906	FUT4/B3GNT2/FUT5/B4GALT2/FUT3/ST8SIA1/B3GALNT1/B3GNT4/B4GALT1/FUT2/ST3GAL4	11
KEGG	hsa04213	Longevity regulating pathway - multiple species	21/1836	62/8135	0.02738	0.08967	0.06104	AKT2/PRKACB/ADCY7/ADCY6/PIK3CB/CLPB/NRAS/PIK3R1/PIK3CA/HSPA1L/IRS2/ADCY8/PRKACA/PRKAA2/HDAC1/FOXO3/EIF4EBP2/PRKAB2/ATG5/PRKACG/ADCY1	21
KEGG	hsa04540	Gap junction	28/1836	88/8135	0.02837	0.092	0.06263	PRKACB/GNAI3/PRKCB/ADCY7/CSNK1D/ADCY6/GNA11/CDK1/ITPR2/EGFR/ITPR1/TUBA8/TUBB/NRAS/GJD2/TUBB2A/PRKG1/ADCY8/TUBA1A/PRKACA/PDGFC/PRKCG/ITPR3/TUBA1B/PRKACG/MAPK1/PDGFA/ADCY1	28
KEGG	hsa04071	Sphingolipid signaling pathway	36/1836	119/8135	0.03106	0.09974	0.0679	AKT2/MAPK14/MAPK9/GNAI3/PRKCZ/PPP2CB/PRKCB/SGPP1/CERS6/SGPL1/SPTLC3/PIK3CB/PPP2R1A/SMPD2/ADORA1/PPP2R5C/NRAS/PIK3R1/PIK3CA/CERS4/RAC2/PRKCE/S1PR5/TNFRSF1A/NFKB1/ADORA3/SMPD1/TP53/MAPK13/TRADD/PPP2CA/MAP3K5/ROCK1/PRKCG/OPRD1/MAPK1	36
KEGG	hsa05310	Asthma	12/1836	31/8135	0.03143	0.09997	0.06805	HLA-DOB/IL13/HLA-DMB/CD40/IL5/HLA-DPA1/CD40LG/PRG2/HLA-DPB1/HLA-DMA/HLA-DRA/IL10	12
KEGG	hsa00061	Fatty acid biosynthesis	8/1836	18/8135	0.03248	0.1022	0.06959	ACSL5/ACSL6/FASN/ACACB/MECR/ACSL3/OXSM/HSD17B8	8
KEGG	hsa04211	Longevity regulating pathway	28/1836	89/8135	0.03275	0.1022	0.06959	AKT2/PRKACB/ADCY7/EHMT1/ADCY6/STK11/PIK3CB/ADIPOR1/RHEB/NRAS/PIK3R1/PIK3CA/ATG13/IRS2/NFKB1/ADCY8/PRKACA/TP53/APPL1/PRKAA2/FOXO3/PRKAB2/EIF4E2/ULK1/ATG5/PRKACG/PPARG/ADCY1	28
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/1836	15/8135	0.03386	0.1038	0.07065	ST8SIA1/SLC33A1/ST8SIA5/ST6GALNAC4/B3GALT4/HEXB/ST3GAL5	7
KEGG	hsa04612	Antigen processing and presentation	25/1836	78/8135	0.03387	0.1038	0.07065	RFX5/TAP1/HLA-DOB/CD8A/PSME1/HLA-F/TAPBP/HSP90AA1/HLA-DMB/HLA-C/HLA-DPA1/KLRD1/RFXANK/HLA-DPB1/HLA-G/HLA-DMA/IFNG/HSPA1L/HLA-A/CD74/KIR2DS3/HLA-DRA/NFYB/LGMN/B2M	25
KEGG	hsa04720	Long-term potentiation	22/1836	67/8135	0.03447	0.1047	0.07125	PRKACB/GRIN2C/PRKCB/RPS6KA1/PPP1CA/ITPR2/CREBBP/ARAF/PPP3CC/ITPR1/NRAS/ADCY8/PRKACA/CALM1/CAMK2B/PPP3CB/PRKCG/ITPR3/PRKACG/MAPK1/CALML3/ADCY1	22
KEGG	hsa04217	Necroptosis	46/1836	159/8135	0.03536	0.1064	0.07243	IRF9/JAK2/FAS/TNFSF10/STAT1/MAPK9/BIRC3/PARP1/VDAC3/TLR3/CASP1/STAT4/JAK3/HSP90AA1/RBCK1/PLA2G4A/TNFRSF10B/FTL/GLUD1/PPID/SQSTM1/STAT5A/STAT6/IFNAR1/TRAF5/PLA2G4C/IFNA1/IFNGR2/IFNG/JAK1/FADD/TNFRSF1A/GLUL/SMPD1/FASLG/IFNAR2/TRADD/SLC25A31/CAMK2B/CHMP7/CYBB/EIF2AK2/PYCARD/SLC25A4/IFNA5/XIAP	46
KEGG	hsa04911	Insulin secretion	27/1836	86/8135	0.03647	0.1083	0.07374	PRKACB/KCNMB1/PRKCB/KCNN4/ADCY7/ADCY6/GNA11/KCNN3/KCNN2/CACNA1S/ADCY8/GCK/PRKACA/STX1A/ATP1B3/ADCYAP1R1/SLC2A2/PDX1/CAMK2B/ATP1B2/ABCC8/PRKCG/GIP/KCNMB4/ITPR3/PRKACG/ADCY1	27
KEGG	hsa04142	Lysosome	39/1836	132/8135	0.03665	0.1083	0.07374	AP3D1/CTSW/GM2A/AGA/GNPTAB/AP1S2/CTSC/AP1S1/ATP6V1H/WDR7/LAMP3/ABCA2/ACP2/CLN5/AP3B1/DMXL1/CTSH/NAGA/MAN2B1/ATP6AP1/CTSO/IDS/LAMP1/AP3B2/SMPD1/SLC11A1/LAPTM4A/DMXL2/SCARB2/ABCB9/TCIRG1/MCOLN1/TPP1/SORT1/HEXB/CTSG/AP1G2/LGMN/CLTC	39
KEGG	hsa04066	HIF-1 signaling pathway	33/1836	109/8135	0.03736	0.1095	0.07451	AKT2/PLCG2/CUL2/PRKCB/RBX1/ENO1/PDK1/PIK3CB/EGFR/CDKN1A/CREBBP/ENO2/ENO3/PIK3R1/PIK3CA/IFNGR2/IFNG/EGLN3/NFKB1/RPS6/EPO/CDKN1B/LDHAL6B/ANGPT2/TFRC/ALDOC/EIF4E2/CAMK2B/LTBR/PRKCG/CYBB/MAPK1/HMOX1	33
KEGG	hsa04020	Calcium signaling pathway	66/1836	240/8135	0.04	0.1157	0.07873	PLCG2/PRKACB/FGFR1/CD38/GRIN2C/ASPH/PDE1B/VDAC3/PTGER1/PRKCB/CACNA1I/ADCY7/FGFR4/FGF21/EDNRB/CACNA1B/RYR1/GNA11/TACR2/NTRK2/NTRK1/P2RX6/CXCR4/ITPR2/EGFR/HTR6/PPP3CC/ITPR1/GDNF/CACNA1E/F2R/CACNA1H/CACNA1S/ATP2B4/FGF17/ATP2A3/PHKB/ADCY8/PRKACA/ITPKA/CALM1/PLCD1/PPIF/P2RX2/MCOLN1/FGF5/SLC25A31/FGF3/NTSR1/CAMK2B/PHKG1/PPP3CB/ITPKB/PDGFC/PRKCG/HRH1/HRH2/ATP2A1/P2RX1/ITPR3/PRKACG/CALML3/PDGFA/SLC25A4/PHKA1/ADCY1	66
KEGG	hsa04014	Ras signaling pathway	64/1836	232/8135	0.04017	0.1157	0.07873	AKT2/PLCG2/PRKACB/BCL2L1/EXOC2/FGFR1/MAPK9/PAK2/PRKCB/PLA2G2D/RASGRP1/RASA1/RASA3/FGFR4/FGF21/NTRK2/PAK3/NTRK1/PLA2G4A/CSF1R/PIK3CB/EGFR/KITLG/TBK1/GNG3/CSF1/REL/RASGRF1/PLA2G2E/PLA2G4C/NRAS/PIK3R1/PIK3CA/PLA2G6/RAC2/LAT/RGL1/EFNA5/FGF17/ETS1/NFKB1/PRKACA/FLT3LG/CALM1/FASLG/EFNA4/ANGPT2/RASGRP3/FGF5/PLA1A/FGF3/RRAS/ARF6/PLA2G12A/GNB3/PDGFC/PRKCG/PAK1/PRKACG/MAPK1/CALML3/BDNF/PDGFA/SHC1	64
KEGG	hsa04024	cAMP signaling pathway	61/1836	221/8135	0.04383	0.1251	0.08518	AKT2/PRKACB/ABCC4/MAPK9/GNAI3/GRIN2C/PPP1R12A/VIPR2/ADCY7/JUN/ADCY6/PIK3CB/PPP1CA/VAV2/HTR6/CREBBP/ADORA1/SOX9/EDN2/GIPR/SSTR1/GLI1/PIK3R1/PIK3CA/LIPE/RAC2/FSHB/F2R/VAV1/CACNA1S/ATP2B4/ATP2A3/NFKB1/ADCY8/GHSR/PRKACA/HCN2/PDE4B/CRH/ATP1B3/CALM1/FOS/ADCYAP1R1/SSTR2/VAV3/RRAS/CAMK2B/POMC/ROCK1/ATP1B2/PAK1/GIP/ATP2A1/PRKACG/MAPK1/CALML3/ACOX3/BDNF/SSTR5/FXYD1/ADCY1	61
KEGG	hsa05213	Endometrial cancer	19/1836	58/8135	0.04825	0.1366	0.09297	AKT2/MLH1/GADD45B/LEF1/CTNNB1/DDB2/PIK3CB/EGFR/CDKN1A/ARAF/MYC/BAK1/NRAS/PIK3R1/PIK3CA/CTNNA1/TP53/FOXO3/MAPK1	19
KEGG	hsa05131	Shigellosis	67/1836	247/8135	0.05036	0.1413	0.09622	AKT2/PLCG2/BCL2L1/RIPK2/CCL5/MAPK14/ATM/MAPK9/MALT1/TNIP1/TAB2/IL1R1/ELMO1/FBXW11/RBX1/CASP1/PRKCQ/ACTR2/PXN/JUN/CYTH3/TRAF6/FNBP1/ARPC5/UBC/RBCK1/CYTH1/PIK3CB/ITPR2/PPID/SQSTM1/EGFR/WASL/GLMN/TBK1/CSF2/TRAF5/RPS6KA5/ITPR1/MYL5/UBE2D4/PIK3R1/PIK3CA/IL18/MAP3K7/PRKCE/PRKCD/WIPI1/TNFRSF1A/NFKB1/ACTR3/UBB/CD14/PLCD1/TP53/MAPK13/FOXO3/MYD88/TRADD/TLN2/ARF6/ROCK1/ATG5/GSK3A/ITPR3/MAPK1/PYCARD	67
KEGG	hsa04931	Insulin resistance	32/1836	108/8135	0.05251	0.1457	0.0992	AKT2/SOCS3/MAPK9/PRKCZ/PRKCB/PRKCQ/PTPRF/RPS6KA1/PIK3CB/PPP1CA/NR1H3/AGT/MLXIPL/PIK3R1/PIK3CA/G6PC3/PRKCE/ACACB/PRKCD/MLXIP/IRS2/TNFRSF1A/NFKB1/PTPN1/SLC27A5/PRKAA2/TBC1D4/SLC2A2/PRKAB2/SLC2A4/SLC27A3/GYS1	32
KEGG	hsa00920	Sulfur metabolism	5/1836	10/8135	0.05279	0.1457	0.0992	PAPSS1/PAPSS2/BPNT1/SUOX/ETHE1	5
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1836	70/8135	0.05459	0.1495	0.1017	PLCG2/CCL5/MAPK14/MAPK9/ATP6V1D/ADAM10/ATP6V0E1/JUN/ATP6V1H/MAP2K4/EGFR/ATP6V1A/CASP3/ATP6V1E1/ATP6AP1/GIT1/NFKB1/CSK/MAPK13/HBEGF/TCIRG1/PAK1	22
KEGG	hsa05010	Alzheimer disease	100/1836	384/8135	0.0559	0.1518	0.1033	AKT2/FAS/MAP2K7/MAPK9/NDUFA9/GRIN2C/LRP1/ADAM10/VDAC3/LRP6/IDE/FZD2/ATG2B/CTNNB1/NDUFS3/WNT7A/FZD3/PSMC2/NDUFS1/SNCA/APP/PIK3CB/WNT5A/PSMD3/ITPR2/PPID/FRAT1/SLC39A6/CASP3/NDUFS7/ARAF/PPP3CC/CDK5/CSF1/RTN4/PSMA5/ITPR1/TUBA8/TUBB/KLC1/NRAS/PIK3R1/PIK3CA/NOX1/SLC39A7/PSMD8/WNT6/PSMB5/CACNA1S/PSMB2/ATG13/PSMA4/WIPI1/FADD/ATP2A3/TUBB2A/IRS2/TNFRSF1A/NFKB1/SDHA/TUBA1A/SLC39A8/NDUFA8/CALM1/PTGS2/PPIF/PSEN1/XBP1/PSMA2/DVL1/SLC25A31/PSMD4/MAP3K5/DKK2/NDUFB3/COX6A2/ULK1/WNT11/PPP3CB/PSMB7/PSMB4/ATP2A1/ITPR3/TUBA1B/CYBB/KIF5C/MAPT/NOX4/MAPK1/CALML3/EIF2AK2/NDUFB5/UQCRC1/FZD6/APBB1/SLC25A4/WNT8B/DKK4/ERN1/FZD1	100
KEGG	hsa04370	VEGF signaling pathway	19/1836	59/8135	0.05664	0.1526	0.1038	AKT2/PLCG2/MAPK14/PRKCB/PXN/PLA2G4A/PIK3CB/PPP3CC/SH2D2A/PLA2G4C/NRAS/PIK3R1/PIK3CA/RAC2/PTGS2/MAPK13/PPP3CB/PRKCG/MAPK1	19
KEGG	hsa04725	Cholinergic synapse	33/1836	113/8135	0.05943	0.1588	0.1081	AKT2/JAK2/PRKACB/GNAI3/KCNJ4/PRKCB/ADCY7/CACNA1B/ADCY6/GNA11/KCNJ2/PIK3CB/ITPR2/PIK3R5/KCNQ4/GNG3/ITPR1/NRAS/PIK3R1/PIK3CA/SLC18A3/CACNA1S/ADCY8/PRKACA/CHAT/FOS/CAMK2B/GNB3/PRKCG/ITPR3/PRKACG/MAPK1/ADCY1	33
KEGG	hsa04910	Insulin signaling pathway	39/1836	137/8135	0.06181	0.1639	0.1115	AKT2/PRKACB/SOCS3/MAPK9/RAPGEF1/PRKCZ/PTPRF/FLOT2/PIK3CB/PPP1CA/ARAF/FASN/RHEB/NRAS/PIK3R1/PIK3CA/LIPE/G6PC3/ACACB/IRS2/PHKB/PTPN1/GCK/PRKACA/EXOC7/RPS6/CALM1/PRKAA2/PRKAB2/EIF4E2/SOCS2/SLC2A4/PHKG1/PRKACG/MAPK1/CALML3/PHKA1/SHC1/GYS1	39
KEGG	hsa04350	TGF-beta signaling pathway	28/1836	94/8135	0.06263	0.1645	0.112	TGFBR2/PPP2CB/RBX1/SMAD6/CHRD/ZFYVE9/GDF5/ID4/ID2/TGFB2/CREBBP/PPP2R1A/MYC/AMHR2/LEFTY1/IFNG/SMAD2/CDKN2B/HAMP/BMP8A/E2F4/ZFYVE16/PPP2CA/RBL1/ROCK1/MAPK1/INHBA/GREM1	28
KEGG	hsa04923	Regulation of lipolysis in adipocytes	18/1836	56/8135	0.06347	0.1645	0.112	AKT2/PRKACB/GNAI3/ADCY7/PNPLA2/ADCY6/PIK3CB/ADORA1/PIK3R1/PIK3CA/LIPE/IRS2/PRKG1/ADCY8/PRKACA/PTGS2/PRKACG/ADCY1	18
KEGG	hsa01522	Endocrine resistance	29/1836	98/8135	0.06352	0.1645	0.112	AKT2/PRKACB/NCOR1/MAPK14/MAPK9/ADCY7/E2F3/JUN/ADCY6/PIK3CB/EGFR/CDKN1A/ARAF/NRAS/PIK3R1/PIK3CA/BIK/ADCY8/PRKACA/CYP2D6/CDKN1B/FOS/TP53/MAPK13/HBEGF/PRKACG/MAPK1/SHC1/ADCY1	29
KEGG	hsa05146	Amoebiasis	30/1836	102/8135	0.06431	0.1646	0.112	PRKACB/IL1R1/PRKCB/GNA11/ITGB2/PIK3CB/C8G/TGFB2/LAMC3/CASP3/CSF2/MUC2/FN1/PIK3R1/PIK3CA/COL4A3/IFNG/SERPINB6/NFKB1/PRKACA/CD14/CD1D/LAMA2/CTSG/PRKCG/COL3A1/SERPINB4/IL10/PRKACG/ADCY1	30
KEGG	hsa03022	Basal transcription factors	15/1836	45/8135	0.06455	0.1646	0.112	TAF15/GTF2E1/GTF2I/TAF1/GTF2IRD1/CDK7/GTF2E2/TAF6L/GTF2H1/TAF5L/TAF12/GTF2B/GTF2H4/GTF2H5/TBP	15
KEGG	hsa04730	Long-term depression	19/1836	60/8135	0.06599	0.1649	0.1123	GNAI3/PPP2CB/PRKCB/RYR1/GNA11/PLA2G4A/ITPR2/PPP2R1A/ARAF/ITPR1/PLA2G4C/GNAZ/NRAS/PRKG1/CRH/PPP2CA/PRKCG/ITPR3/MAPK1	19
KEGG	hsa04015	Rap1 signaling pathway	57/1836	210/8135	0.06607	0.1649	0.1123	AKT2/FGFR1/MAPK14/GNAI3/RAPGEF1/PRKCZ/EVL/PRKCB/ADCY7/CTNNB1/FGFR4/FGF21/ADCY6/APBB1IP/PRKD2/ITGB2/RAP1GAP/SIPA1/CSF1R/PIK3CB/SKAP1/RAPGEF6/VAV2/EGFR/KITLG/CSF1/CNR1/ITGB3/NRAS/PIK3R1/PIK3CA/RAC2/LAT/F2R/VAV1/EFNA5/FGF17/ADCY8/PARD3/CALM1/MAGI1/EFNA4/ITGAL/MAPK13/ANGPT2/VAV3/RASGRP3/FGF5/FGF3/RRAS/TLN2/PDGFC/PRKCG/MAPK1/CALML3/PDGFA/ADCY1	57
KEGG	hsa04670	Leukocyte transendothelial migration	33/1836	114/8135	0.06617	0.1649	0.1123	PLCG2/MAPK14/GNAI3/EZR/PRKCB/PXN/CTNNB1/ITGA4/ITGB2/NCF1/ITK/RHOH/SIPA1/PIK3CB/CXCR4/VAV2/TXK/MYL5/ARHGAP35/PIK3R1/PIK3CA/CLDN11/RAC2/NCF4/CTNNA1/VAV1/CYBA/ITGAL/MAPK13/VAV3/ROCK1/PRKCG/CYBB	33
KEGG	hsa00910	Nitrogen metabolism	7/1836	17/8135	0.06723	0.1663	0.1132	CA12/GLUD1/CA5A/GLUL/CA2/CA4/CA5B	7
KEGG	hsa04120	Ubiquitin mediated proteolysis	40/1836	142/8135	0.0682	0.1667	0.1135	CUL2/SOCS3/UBE2J1/UBE2L6/BIRC3/UBE2A/HERC1/FBXW11/RBX1/UBE2G2/TRAF6/UBE2H/UBC/DET1/CDC20/DDB2/UBA3/CDC16/AIRE/UBE2G1/UBE2L3/UBE2Z/UBE2D4/UBE2Q1/CBLC/UBE2C/FANCL/RNF7/STUB1/UBB/PIAS4/UBE4A/HERC4/TRIM37/PRPF19/CDC23/FBXW7/BRCA1/TRIP12/XIAP	40
KEGG	hsa04921	Oxytocin signaling pathway	43/1836	154/8135	0.06837	0.1667	0.1135	PRKACB/CD38/GNAI3/KCNJ4/PPP1R12A/EEF2/PRKCB/ADCY7/JUN/RYR1/ADCY6/KCNJ2/CACNG2/MYL6/PLA2G4A/PPP1CA/ITPR2/EGFR/PIK3R5/NFATC4/CDKN1A/CACNG1/PPP3CC/ITPR1/PLA2G4C/NRAS/CACNA1S/ADCY8/PRKACA/CALM1/FOS/PTGS2/PRKAA2/PRKAB2/CAMK2B/ROCK1/PPP3CB/PRKCG/ITPR3/PRKACG/MAPK1/CALML3/ADCY1	43
KEGG	hsa04710	Circadian rhythm	11/1836	31/8135	0.07064	0.171	0.1164	BHLHE41/FBXW11/RBX1/CSNK1D/PER3/NPAS2/BHLHE40/CLOCK/PRKAA2/PRKAB2/ARNTL	11
KEGG	hsa05133	Pertussis	23/1836	76/8135	0.07349	0.1753	0.1193	MAPK14/MAPK9/GNAI3/CASP1/JUN/TRAF6/IRF8/ITGB2/CASP3/LY96/NFKB1/CD14/CALM1/FOS/CXCL6/MAPK13/MYD88/IRF1/IL10/MAPK1/CALML3/IRAK4/PYCARD	23
KEGG	hsa05212	Pancreatic cancer	23/1836	76/8135	0.07349	0.1753	0.1193	AKT2/BCL2L1/STAT1/MAPK9/TGFBR2/GADD45B/E2F3/BRCA2/DDB2/PIK3CB/EGFR/TGFB2/CDKN1A/ARAF/BAK1/PIK3R1/PIK3CA/RAC2/JAK1/NFKB1/SMAD2/TP53/MAPK1	23
KEGG	hsa00510	N-Glycan biosynthesis	16/1836	50/8135	0.07998	0.1875	0.1277	ALG6/DPAGT1/FUT8/MAN2A1/B4GALT2/MGAT3/MGAT4A/ST6GAL1/ALG9/B4GALT1/ALG5/ALG8/RPN2/MGAT5/MGAT2/RPN1	16
KEGG	hsa05144	Malaria	16/1836	50/8135	0.07998	0.1875	0.1277	LRP1/SDC1/ITGB2/CD40/TGFB2/CD40LG/CR1/IL18/IFNG/KLRB1/ITGAL/THBS2/MYD88/IL10/GYPC/CSF3	16
KEGG	hsa05211	Renal cell carcinoma	21/1836	69/8135	0.08029	0.1875	0.1277	AKT2/CUL2/RAPGEF1/PAK2/RBX1/EPAS1/JUN/PAK3/PIK3CB/TFE3/TGFB2/CDKN1A/CREBBP/ARAF/NRAS/PIK3R1/PIK3CA/ETS1/EGLN3/PAK1/MAPK1	21
KEGG	hsa04145	Phagosome	42/1836	152/8135	0.08159	0.1893	0.1288	TAP1/STX18/ATP6V1D/FCGR2B/SEC22B/HLA-DOB/ATP6V0E1/STX12/ATP6V1H/HLA-F/ITGB2/NCF1/HLA-DMB/ATP6V1A/HLA-C/HLA-DPA1/ITGB3/ATP6V1E1/TUBA8/CORO1A/TUBB/HLA-DPB1/HLA-G/NCF4/HLA-DMA/DYNC1I2/ATP6AP1/TUBB2A/LAMP1/COLEC12/TUBA1A/CYBA/CD14/HLA-A/TCIRG1/THBS2/TFRC/STX7/HLA-DRA/TUBA1B/CYBB/MSR1	42
KEGG	hsa04713	Circadian entrainment	28/1836	97/8135	0.08784	0.2023	0.1377	PRKACB/GNAI3/GRIN2C/PRKCB/CACNA1I/ADCY7/RYR1/ADCY6/PER3/GNG3/RPS6KA5/ITPR1/CACNA1H/PRKG1/ADCY8/PRKACA/CALM1/FOS/ADCYAP1R1/CAMK2B/GNB3/PRKCG/MTNR1B/ITPR3/PRKACG/MAPK1/CALML3/ADCY1	28
KEGG	hsa04514	Cell adhesion molecules	41/1836	149/8135	0.08909	0.2038	0.1387	PTPRC/SDC1/HLA-DOB/CD8A/CD2/ALCAM/MAG/PTPRF/ITGA4/PVR/HLA-F/ITGB2/CD86/CADM3/CTLA4/PDCD1LG2/ICAM2/CDH15/HLA-DMB/CD40/HLA-C/NLGN4X/HLA-DPA1/SPN/NRXN1/CD40LG/CLDN11/HLA-DPB1/HLA-G/MPZL1/ITGB7/CD80/HLA-DMA/ICAM3/HLA-A/SIGLEC1/ITGAL/NLGN4Y/HLA-DRA/CNTN1/CD58	41
KEGG	hsa04622	RIG-I-like receptor signaling pathway	21/1836	70/8135	0.0913	0.2074	0.1412	CXCL10/IFIH1/RNF125/MAPK14/MAPK9/TRAF6/TRIM25/DDX58/TRAF3/TBK1/TBKBP1/IFNA1/MAP3K7/IRF7/FADD/NFKB1/MAPK13/NLRX1/TRADD/ATG5/IFNA5	21
KEGG	hsa04360	Axon guidance	49/1836	182/8135	0.09329	0.2105	0.1433	PLCG2/GNAI3/EFNB1/PRKCZ/PAK2/SEMA4D/RASA1/NCK1/SEMA4A/FZD3/RND1/PAK3/EFNB2/PIK3CB/WNT5A/SHH/SEMA6D/CXCR4/SEMA3B/SLIT1/NFATC4/PLXNB1/NTN3/PPP3CC/SEMA6A/CDK5/MYL5/NRAS/PIK3R1/PIK3CA/RAC2/SEMA4G/EFNA5/PARD3/EFNA4/EPHB6/RRAS/SEMA7A/ABLIM1/CAMK2B/ROCK1/TRPC4/PPP3CB/SEMA6C/PAK1/MAPK1/SEMA3C/RHOD/SEMA4C	49
KEGG	hsa04330	Notch signaling pathway	18/1836	59/8135	0.09819	0.2201	0.1498	HES1/RBPJL/MFNG/HEYL/KAT2B/CREBBP/PTCRA/NCOR2/TLE6/LFNG/HDAC1/PSEN1/MAML1/TLE2/DVL1/RBPJ/MAML3/TLE1	18
KEGG	hsa05217	Basal cell carcinoma	19/1836	63/8135	0.1002	0.223	0.1518	GADD45B/LEF1/FZD2/CTNNB1/WNT7A/FZD3/DDB2/WNT5A/SHH/CDKN1A/BAK1/GLI1/WNT6/TP53/DVL1/WNT11/FZD6/WNT8B/FZD1	19
KEGG	hsa00900	Terpenoid backbone biosynthesis	8/1836	22/8135	0.1015	0.2245	0.1529	MVK/DHDDS/ICMT/GGPS1/MVD/HMGCR/ZMPSTE24/PDSS2	8
KEGG	hsa04022	cGMP-PKG signaling pathway	45/1836	167/8135	0.103	0.2263	0.154	AKT2/GNAI3/PPP1R12A/GTF2I/KCNMB1/VDAC3/ADCY7/GTF2IRD1/EDNRB/ADCY6/GNA11/ADRA2B/PPP1CA/ITPR2/SRF/PIK3R5/NFATC4/PPP3CC/ADORA1/ITPR1/CACNA1S/ATP2B4/PRKCE/ATP2A3/NPPB/IRS2/PRKG1/ADCY8/ADORA3/ATP1B3/CALM1/PPIF/SLC25A31/ROCK1/ATP1B2/PPP3CB/OPRD1/ATP2A1/KCNMB4/ITPR3/MAPK1/CALML3/MEF2D/SLC25A4/ADCY1	45
KEGG	hsa05214	Glioma	22/1836	75/8135	0.1044	0.2269	0.1544	AKT2/PLCG2/GADD45B/PRKCB/E2F3/DDB2/PIK3CB/EGFR/CDKN1A/ARAF/BAK1/NRAS/PIK3R1/PIK3CA/CALM1/TP53/CAMK2B/PRKCG/MAPK1/CALML3/PDGFA/SHC1	22
KEGG	hsa05012	Parkinson disease	69/1836	266/8135	0.1046	0.2269	0.1544	PRKACB/BCL2L1/MFN2/UBE2J1/DUSP1/MAPK9/UBE2L6/NDUFA9/GNAI3/VDAC3/UBE2G2/NDUFS3/UBC/PSMC2/NDUFS1/SNCA/UBE2G1/PSMD3/ITPR2/SLC39A6/CASP3/UBE2L3/NDUFS7/PSMA5/ITPR1/TUBA8/TUBB/KLC1/SLC39A7/PSMD8/TXN2/PSMB5/MFN1/PSMB2/SLC6A3/PSMA4/TUBB2A/SDHA/TUBA1A/SLC39A8/PRKACA/TH/NDUFA8/UBB/CALM1/TRAP1/UCHL1/TP53/PPIF/XBP1/PSMA2/SLC25A31/PSMD4/MAP3K5/CAMK2B/NDUFB3/COX6A2/PSMB7/PSMB4/ITPR3/TUBA1B/KIF5C/MAPT/PRKACG/CALML3/NDUFB5/UQCRC1/SLC25A4/ERN1	69
KEGG	hsa05418	Fluid shear stress and atherosclerosis	38/1836	139/8135	0.1065	0.2295	0.1562	AKT2/MAP2K7/DUSP1/MAPK14/MAPK9/PRKCZ/IL1R1/SDC1/GPC1/JUN/CTNNB1/NCF1/HSP90AA1/PIK3CB/MAP2K4/SQSTM1/SUMO3/ITGB3/PIK3R1/PIK3CA/NOX1/MAP3K7/RAC2/TXN2/IFNG/TNFRSF1A/NFKB1/CYBA/CALM1/FOS/PIAS4/TP53/MAPK13/PRKAA2/MAP3K5/HMOX1/CALML3/PDGFA	38
KEGG	hsa05225	Hepatocellular carcinoma	45/1836	168/8135	0.1111	0.2379	0.1619	AKT2/PLCG2/BCL2L1/BRD7/TGFBR2/ARID1A/GADD45B/LEF1/LRP6/PRKCB/E2F3/FZD2/CTNNB1/DPF1/WNT7A/FZD3/SMARCA4/DDB2/PIK3CB/WNT5A/TERT/EGFR/FRAT1/TGFB2/CDKN1A/ARAF/MYC/BAK1/NRAS/PIK3R1/PIK3CA/TXNRD2/WNT6/SMAD2/TP53/DVL1/WNT11/PRKCG/MAPK1/HMOX1/FZD6/WNT8B/SHC1/FZD1/SMARCD3	45
KEGG	hsa05219	Bladder cancer	13/1836	41/8135	0.1143	0.2428	0.1653	E2F3/EGFR/CDKN1A/UPK3A/MMP1/ARAF/MYC/RPS6KA5/NRAS/TP53/HBEGF/MAPK1/DAPK2	13
KEGG	hsa04137	Mitophagy - animal	21/1836	72/8135	0.1161	0.2428	0.1653	GABARAPL1/BCL2L1/MFN2/MAPK9/JUN/OPTN/UBC/TFE3/SQSTM1/TBK1/NRAS/MFN1/TFEB/UBB/TP53/FOXO3/USP8/RRAS/ULK1/ATG5/RHOT1	21
KEGG	hsa05218	Melanoma	21/1836	72/8135	0.1161	0.2428	0.1653	AKT2/FGFR1/GADD45B/E2F3/FGF21/DDB2/PIK3CB/EGFR/CDKN1A/ARAF/BAK1/NRAS/PIK3R1/PIK3CA/FGF17/TP53/FGF5/FGF3/PDGFC/MAPK1/PDGFA	21
KEGG	hsa04810	Regulation of actin cytoskeleton	57/1836	218/8135	0.1164	0.2428	0.1653	GSN/FGFR1/SCIN/IQGAP2/PIP5K1A/EZR/PPP1R12A/PAK2/ITGB4/CYFIP2/ACTR2/PXN/FGFR4/PIP5K1B/ITGA7/FGF21/ITGA4/ARPC5/ITGB2/PAK3/BAIAP2/INSRR/PIK3CB/CXCR4/PPP1CA/VAV2/EGFR/WASL/ARAF/MYL5/ITGB3/FN1/ARHGAP35/NRAS/PIK3R1/PIK3CA/RAC2/ITGB7/PIP4K2C/F2R/VAV1/FGF17/GIT1/ACTR3/IQGAP1/ITGAL/VAV3/FGF5/TMSB4Y/FGF3/RRAS/ROCK1/MYH14/PDGFC/PAK1/MAPK1/PDGFA	57
KEGG	hsa05220	Chronic myeloid leukemia	22/1836	76/8135	0.117	0.2428	0.1653	AKT2/BCL2L1/TGFBR2/GADD45B/E2F3/DDB2/PIK3CB/TGFB2/STAT5A/CDKN1A/ARAF/MYC/BAK1/NRAS/PIK3R1/PIK3CA/NFKB1/CDKN1B/TP53/HDAC1/MAPK1/SHC1	22
KEGG	hsa04152	AMPK signaling pathway	33/1836	120/8135	0.118	0.2433	0.1656	AKT2/RAB8A/CAB39/CCNA2/PPP2CB/EEF2/TBC1D1/STK11/PIK3CB/HNF4A/PPP2R1A/ADIPOR1/FASN/RHEB/PPP2R5C/PIK3R1/PIK3CA/LIPE/MAP3K7/G6PC3/ACACB/IRS2/HMGCR/PRKAA2/FOXO3/PRKAB2/PPP2CA/ULK1/SLC2A4/CAB39L/PFKFB4/GYS1/PPARG	33
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	8/1836	23/8135	0.1263	0.2587	0.1761	SLC25A10/GLUD1/SLC38A3/ATP1B3/CA2/MDH1/CA4/ATP1B2	8
KEGG	hsa00562	Inositol phosphate metabolism	21/1836	73/8135	0.13	0.2624	0.1787	PLCG2/FIG4/PI4K2A/PIP5K1A/MTMR6/MTMR4/PIP5K1B/MTMR3/MTMR14/PIK3CB/MINPP1/MTM1/TPI1/PIK3CA/PIP4K2C/PIK3C2B/ITPKA/PLCD1/PI4KA/ITPKB/INPP5D	21
KEGG	hsa05215	Prostate cancer	27/1836	97/8135	0.1311	0.2624	0.1787	AKT2/FGFR1/LEF1/CCNE2/E2F3/CTNNB1/AR/HSP90AA1/INSRR/PIK3CB/EGFR/CDKN1A/CCNE1/CREBBP/ARAF/NRAS/PIK3R1/PIK3CA/NFKB1/TMPRSS2/CDKN1B/TP53/KLK3/PDGFC/MAPK1/PDGFA/SRD5A2	27
KEGG	hsa04970	Salivary secretion	26/1836	93/8135	0.1312	0.2624	0.1787	PRKACB/CD38/PRKCB/KCNN4/ADCY7/ADCY6/BEST2/ITPR2/ITPR1/STATH/CAMP/ATP2B4/PRKG1/ADCY8/TRPV6/PRKACA/ATP1B3/CALM1/HTN1/ATP1B2/PRKCG/CST4/ITPR3/PRKACG/CALML3/ADCY1	26
KEGG	hsa04976	Bile secretion	25/1836	89/8135	0.1312	0.2624	0.1787	PRKACB/ABCC4/LDLR/ADCY7/UGT2B17/ADCY6/KCNN2/NR0B2/SLC22A7/ABCB1/AQP8/ADCY8/SLC27A5/PRKACA/HMGCR/ATP1B3/CA2/SCT/SLC22A1/ATP1B2/UGT2A3/PRKACG/UGT2B4/RXRA/ADCY1	25
KEGG	hsa04966	Collecting duct acid secretion	9/1836	27/8135	0.1347	0.2677	0.1822	ATP6V1D/CLCNKB/ATP6V0E1/ATP6V1A/ATP6V1E1/ATP4A/SLC12A7/CA2/TCIRG1	9
KEGG	hsa04936	Alcoholic liver disease	38/1836	142/8135	0.1354	0.2677	0.1822	AKT2/FAS/MAP2K7/MAPK14/MAPK9/TAB2/LEF1/CTNNB1/TRAF6/MAP2K4/TRAF3/CASP3/TBK1/ADIPOR1/FASN/IFNA1/IL17RC/MAP3K7/LY96/ACACB/FADD/TNFRSF1A/NFKB1/CD14/FABP1/FASLG/TRA2B/MAPK13/PRKAA2/FOXO3/MYD88/TRADD/PRKAB2/MAP3K5/NOX4/ACOX3/IRAK4/IFNA5	38
KEGG	hsa04972	Pancreatic secretion	28/1836	102/8135	0.1433	0.2815	0.1916	RAB8A/CD38/PRKCB/ADCY7/PLA2G2D/ADCY6/CEL/RAB11A/ITPR2/ITPR1/PLA2G2E/RAB3D/ATP2B4/ATP2A3/PRSS2/ADCY8/CELA2B/ATP1B3/CA2/SCT/CPA1/PLA2G12A/ATP1B2/CELA3A/PRKCG/ATP2A1/ITPR3/ADCY1	28
KEGG	hsa00100	Steroid biosynthesis	7/1836	20/8135	0.1441	0.2815	0.1916	CEL/MSMO1/CYP24A1/LSS/LBR/SC5D/DHCR7	7
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	38/1836	143/8135	0.1461	0.2837	0.1931	AKT2/JAK2/FGFR1/MAPK14/IL6ST/FZD2/CTNNB1/FGFR4/WNT7A/FZD3/JAK3/PIK3CB/LIF/WNT5A/ID4/ID2/DUSP9/HOXA1/POU5F1B/KLF4/MYC/NRAS/SOX2/PIK3R1/PIK3CA/LEFTY1/WNT6/JAK1/SMAD2/MAPK13/DVL1/WNT11/LHX5/MAPK1/FZD6/INHBA/WNT8B/FZD1	38
KEGG	hsa04913	Ovarian steroidogenesis	15/1836	51/8135	0.1573	0.3036	0.2067	PRKACB/HSD17B1/LDLR/ADCY7/ADCY6/PLA2G4A/PLA2G4C/FSHB/ADCY8/CYP17A1/PRKACA/PTGS2/CYP1B1/PRKACG/ADCY1	15
KEGG	hsa04623	Cytosolic DNA-sensing pathway	18/1836	63/8135	0.16	0.3043	0.2071	CXCL10/AIM2/CCL5/POLR2F/CASP1/DDX58/TBK1/POLR3B/IFNA1/POLR3G/IL18/IRF7/ADAR/NFKB1/POLR2E/POLR3K/PYCARD/IFNA5	18
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1836	79/8135	0.1601	0.3043	0.2071	AKT2/PLCG2/JAK2/BCL2L1/PRKCB/PIK3CB/EGFR/ARAF/NRAS/GAS6/PIK3R1/PIK3CA/JAK1/RPS6/AXL/FOXO3/EIF4E2/PDGFC/PRKCG/MAPK1/PDGFA/SHC1	22
KEGG	hsa04520	Adherens junction	20/1836	71/8135	0.1605	0.3043	0.2071	FGFR1/TGFBR2/LEF1/CTNNB1/PTPRF/BAIAP2/EGFR/WASL/CREBBP/PTPN6/MAP3K7/RAC2/CTNNA1/NLK/PTPN1/PARD3/IQGAP1/SNAI1/MAPK1/SSX2IP	20
KEGG	hsa04728	Dopaminergic synapse	35/1836	132/8135	0.1612	0.3043	0.2071	AKT2/PRKACB/MAPK14/MAPK9/GNAI3/PPP2CB/PRKCB/CACNA1B/PPP1CA/ITPR2/GNG3/PPP2R1A/PPP3CC/ITPR1/PPP2R5C/CALY/DRD3/SLC6A3/PRKACA/TH/CALM1/FOS/CLOCK/MAPK13/PPP2CA/CAMK2B/GNB3/PPP3CB/PRKCG/GSK3A/ARNTL/ITPR3/KIF5C/PRKACG/CALML3	35
KEGG	hsa04390	Hippo signaling pathway	41/1836	157/8135	0.1641	0.3079	0.2096	DLG5/TGFBR2/BIRC3/PRKCZ/LEF1/PPP2CB/LLGL2/FBXW11/FZD2/CTNNB1/CSNK1D/ITGB2/WNT7A/FZD3/GDF5/WNT5A/ID2/YWHAZ/PPP1CA/YWHAH/TGFB2/MPP5/PPP2R1A/MYC/CCND3/SOX2/CTNNA1/WNT6/SMAD2/PARD3/BMP8A/DVL1/PPP2CA/WNT11/BIRC5/AREG/FZD6/WNT8B/WWTR1/FRMD1/FZD1	41
KEGG	hsa04136	Autophagy - other	10/1836	32/8135	0.1661	0.3083	0.2098	GABARAPL1/ATG4A/PPP2CB/ATG2B/ATG13/WIPI1/PPP2CA/ATG5/ATG4B/ATG7	10
KEGG	hsa04215	Apoptosis - multiple species	10/1836	32/8135	0.1661	0.3083	0.2098	BCL2L1/MAPK9/BIRC3/CASP3/BAK1/FADD/TNFRSF1A/DIABLO/BIRC5/XIAP	10
KEGG	hsa05414	Dilated cardiomyopathy	26/1836	96/8135	0.1725	0.3182	0.2166	PRKACB/ITGB4/ADCY7/SGCA/ITGA7/ITGA4/ADCY6/MYBPC3/CACNG2/EMD/TGFB2/CACNG1/ITGB3/AGT/MYL3/TPM3/ITGB7/CACNA1S/ATP2A3/ADCY8/PRKACA/LAMA2/ATP2A1/PRKACG/DAG1/ADCY1	26
KEGG	hsa04926	Relaxin signaling pathway	34/1836	129/8135	0.1752	0.3214	0.2188	AKT2/PRKACB/MAP2K7/MAPK14/MAPK9/TGFBR2/GNAI3/PRKCZ/ADCY7/JUN/EDNRB/ADCY6/PIK3CB/MAP2K4/EGFR/GNG3/MMP1/NRAS/PIK3R1/PIK3CA/COL4A3/MMP13/NFKB1/ADCY8/SMAD2/PRKACA/FOS/MAPK13/GNB3/COL3A1/PRKACG/MAPK1/SHC1/ADCY1	34
KEGG	hsa04727	GABAergic synapse	24/1836	89/8135	0.1905	0.3477	0.2367	GABARAPL1/PRKACB/HAP1/GNAI3/PRKCB/ADCY7/CACNA1B/ADCY6/GNG3/SLC38A3/CACNA1S/SLC6A11/GLUL/ADCY8/PRKACA/GABRR1/SLC12A5/GAD2/PLCL1/GNB3/PRKCG/PRKACG/GABRR2/ADCY1	24
KEGG	hsa03410	Base excision repair	10/1836	33/8135	0.1929	0.3502	0.2384	PCNA/POLB/PARP1/PARP2/APEX2/POLD3/PARP4/FEN1/POLD2/MBD4	10
KEGG	hsa05143	African trypanosomiasis	11/1836	37/8135	0.1955	0.3509	0.2389	FAS/APOA1/PRKCB/IDO1/IL18/IFNG/APOL1/FASLG/MYD88/PRKCG/IL10	11
KEGG	hsa04924	Renin secretion	19/1836	69/8135	0.1965	0.3509	0.2389	PRKACB/GNAI3/PDE1B/ADCY6/KCNJ2/ITPR2/PPP3CC/ADORA1/ITPR1/AGT/EDN2/CACNA1S/PRKACA/CALM1/ADCYAP1R1/PPP3CB/ITPR3/PRKACG/CALML3	19
KEGG	hsa05031	Amphetamine addiction	19/1836	69/8135	0.1965	0.3509	0.2389	PRKACB/GRIN2C/PRKCB/JUN/PPP1CA/FOSB/PPP3CC/SLC6A3/PRKACA/TH/STX1A/CALM1/FOS/HDAC1/CAMK2B/PPP3CB/PRKCG/PRKACG/CALML3	19
KEGG	hsa04150	mTOR signaling pathway	40/1836	156/8135	0.2017	0.3584	0.244	AKT2/ATP6V1D/SLC3A2/CAB39/LRP6/PRKCB/FZD2/WDR59/STK11/ATP6V1H/GRB10/WNT7A/FZD3/RPS6KA1/PIK3CB/WNT5A/ATP6V1A/RHEB/ATP6V1E1/NRAS/PIK3R1/PIK3CA/NPRL3/WNT6/TNFRSF1A/RPS6/DEPDC5/SEC13/PRKAA2/DVL1/EIF4E2/ULK1/WNT11/PRKCG/SGK1/CAB39L/MAPK1/FZD6/WNT8B/FZD1	40
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1836	26/8135	0.2163	0.3803	0.2589	PIGN/PIGV/PIGF/PIGC/PIGB/PIGQ/PIGK/MPPE1	8
KEGG	hsa04950	Maturity onset diabetes of the young	8/1836	26/8135	0.2163	0.3803	0.2589	HHEX/HES1/HNF1A/HNF4A/GCK/SLC2A2/PDX1/NEUROG3	8
KEGG	hsa01523	Antifolate resistance	9/1836	30/8135	0.2195	0.3839	0.2614	GGH/ABCC4/SLC19A1/TYMS/ATIC/NFKB1/MTHFR/SHMT1/FPGS	9
KEGG	hsa03013	Nucleocytoplasmic transport	28/1836	108/8135	0.2315	0.4027	0.2741	EEF1A1/UPF1/IPO8/NUP37/XPO7/TPR/XPO1/NXT2/POM121C/XPO4/SNUPN/POM121/SUMO3/NXF3/THOC2/NUP133/NUP107/TNPO2/TNPO1/SEC13/IPO9/NUP93/UPF3B/NDC1/NUP210/RANBP17/NUP205/NUP85	28
KEGG	hsa01230	Biosynthesis of amino acids	20/1836	75/8135	0.2339	0.4047	0.2755	IDH3B/GOT2/MAT2A/PGAM1/ENO1/BCAT2/MAT2B/IDH2/TKT/ASL/SDS/TPI1/ENO2/ENO3/GLUL/TALDO1/OTC/ALDOC/SHMT1/PRPS2	20
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1836	15/8135	0.2362	0.4067	0.2769	ST8SIA1/NAGA/B3GALNT1/FUT2/HEXB	5
KEGG	hsa05221	Acute myeloid leukemia	18/1836	67/8135	0.2384	0.4084	0.278	AKT2/CCNA2/LEF1/CSF1R/PIK3CB/PIM2/STAT5A/ARAF/CSF2/MYC/NRAS/PIK3R1/PIK3CA/NFKB1/CD14/ZBTB16/MAPK1/RARA	18
KEGG	hsa00310	Lysine degradation	17/1836	63/8135	0.2406	0.41	0.2791	SMYD2/HADHA/EHMT1/AASS/DHTKD1/EZH2/CAMKMT/ASH1L/PRDM16/NSD1/DLST/SETD1A/KMT2B/SMYD3/PLOD3/SUV39H2/KMT2A	17
KEGG	hsa04915	Estrogen signaling pathway	35/1836	138/8135	0.2425	0.4111	0.2798	AKT2/PRKACB/GNAI3/FKBP5/ADCY7/JUN/KRT33A/ADCY6/HSP90AA1/PIK3CB/ITPR2/EGFR/ITPR1/NRAS/PIK3R1/PIK3CA/KRT32/PRKCD/HSPA1L/OPRM1/ADCY8/PRKACA/CALM1/FOS/HBEGF/POMC/KRT13/NCOA1/ITPR3/PRKACG/MAPK1/RARA/CALML3/SHC1/ADCY1	35
KEGG	hsa04932	Non-alcoholic fatty liver disease	39/1836	155/8135	0.2446	0.4127	0.2809	AKT2/FAS/SOCS3/MAPK14/MAPK9/NDUFA9/JUN/NDUFS3/MAP3K11/NDUFS1/PIK3CB/CASP3/ADIPOR1/NDUFS7/NR1H3/MLXIPL/PIK3R1/PIK3CA/MLXIP/IRS2/TNFRSF1A/NFKB1/SDHA/NDUFA8/FOS/FASLG/MAPK13/PRKAA2/PRKAB2/XBP1/MAP3K5/NDUFB3/COX6A2/GSK3A/RXRA/NDUFB5/UQCRC1/PPARG/ERN1	39
KEGG	hsa00514	Other types of O-glycan biosynthesis	13/1836	47/8135	0.2483	0.4168	0.2837	GALNT10/B4GALT2/MFNG/C1GALT1C1/ST6GAL1/POFUT1/GALNT6/LFNG/B4GALT1/POFUT2/C1GALT1/PLOD3/GALNT8	13
KEGG	hsa00513	Various types of N-glycan biosynthesis	11/1836	39/8135	0.2509	0.419	0.2852	FUT8/MAN2A1/B4GALT2/MGAT4A/ALG9/B4GALT1/CHST8/RPN2/HEXB/MGAT2/RPN1	11
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1836	77/8135	0.2752	0.4573	0.3113	ITGB4/LEF1/SGCA/CTNNB1/DSC2/ITGA7/ITGA4/CACNG2/EMD/CACNG1/DSP/ITGB3/ITGB7/CTNNA1/CACNA1S/ACTN3/ATP2A3/LAMA2/ATP2A1/DAG1	20
KEGG	hsa01200	Carbon metabolism	29/1836	115/8135	0.2792	0.4617	0.3143	IDH3B/GOT2/PGAM1/OGDHL/ADPGK/ENO1/IDH2/H6PD/TKT/GPI/GLUD1/SDS/TPI1/HAO2/GLDC/ENO2/DLST/ENO3/HIBCH/SDHA/TALDO1/GCK/ME1/MDH1/ALDOC/SHMT1/PRPS2/ACOX3/PGP	29
KEGG	hsa00670	One carbon pool by folate	6/1836	20/8135	0.2869	0.4705	0.3203	TYMS/ATIC/MTHFR/ALDH1L1/SHMT1/FTCD	6
KEGG	hsa04977	Vitamin digestion and absorption	7/1836	24/8135	0.2874	0.4705	0.3203	APOA1/SLC19A1/MMACHC/LMBRD1/SLC19A2/APOA4/CUBN	7
KEGG	hsa04141	Protein processing in endoplasmic reticulum	42/1836	171/8135	0.2916	0.4742	0.3228	DNAJC10/SSR1/MAP2K7/UBE2J1/MAPK9/RBX1/RRBP1/UBE2G2/SEC63/TRAM1/HSPA4L/RNF5/HSP90AA1/EDEM1/UBE2G1/SEC24A/SSR4/PLAA/BAK1/UBE2D4/HSPA1L/ATXN3/PDIA4/HERPUD1/DNAJB12/STUB1/SEC23A/PPP1R15A/EIF2AK1/SEC13/XBP1/MAP3K5/RPN2/EDEM3/PREB/EDEM2/NSFL1C/EIF2AK2/RPN1/NPLOC4/DNAJB1/ERN1	42
KEGG	hsa04510	Focal adhesion	49/1836	201/8135	0.2925	0.4742	0.3228	AKT2/MAPK9/BIRC3/PIP5K1A/RAPGEF1/COL6A1/PPP1R12A/PAK2/ITGB4/PRKCB/PXN/JUN/CTNNB1/PIP5K1B/ITGA7/ITGA4/FLNB/PAK3/TNXB/PIK3CB/PPP1CA/VAV2/EGFR/LAMC3/CCND3/MYL5/ITGB3/RASGRF1/FN1/ARHGAP35/PIK3R1/PIK3CA/RAC2/ITGB7/COL4A3/VAV1/VAV3/THBS2/LAMA2/TLN2/ROCK1/PDGFC/PRKCG/PAK1/MAPK1/SPP1/PDGFA/SHC1/XIAP	49
KEGG	hsa05230	Central carbon metabolism in cancer	18/1836	70/8135	0.3058	0.4934	0.3358	AKT2/FGFR1/PGAM1/IDH2/NTRK1/PDK1/PIK3CB/EGFR/MYC/NRAS/PIK3R1/PIK3CA/GCK/SLC1A5/TP53/LDHAL6B/SLC2A2/MAPK1	18
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	10/1836	37/8135	0.3153	0.5063	0.3447	PRKCB/PIK3CB/PIK3R1/PIK3CA/ATP1B3/SLC9A3R2/ATP1B2/PRKCG/SGK1/MAPK1	10
KEGG	hsa04130	SNARE interactions in vesicular transport	9/1836	33/8135	0.3195	0.5106	0.3476	STX18/SEC22B/BET1L/VAMP8/VAMP5/BET1/STX1A/STX7/SNAP23	9
KEGG	hsa03320	PPAR signaling pathway	19/1836	75/8135	0.3241	0.5154	0.3509	APOA1/ACSL5/RXRB/UBC/CYP27A1/FABP6/ACSL6/MMP1/NR1H3/ACSL3/SLC27A5/FABP1/APOA2/RXRG/ME1/ANGPTL4/RXRA/ACOX3/PPARG	19
KEGG	hsa00592	alpha-Linolenic acid metabolism	7/1836	25/8135	0.3276	0.5186	0.353	PLA2G2D/PLA2G4A/PLA2G2E/PLA2G4C/PLA2G6/PLA2G12A/ACOX3	7
KEGG	hsa05110	Vibrio cholerae infection	13/1836	50/8135	0.3309	0.5192	0.3534	PLCG2/PRKACB/ATP6V1D/KDELR3/ATP6V0E1/ATP6V1H/ATP6V1A/ATP6V1E1/ATP6AP1/PDIA4/PRKACA/TCIRG1/PRKACG	13
KEGG	hsa00770	Pantothenate and CoA biosynthesis	6/1836	21/8135	0.3311	0.5192	0.3534	PANK2/BCAT2/PPCS/VNN1/ENPP1/PPCDC	6
KEGG	hsa04072	Phospholipase D signaling pathway	36/1836	148/8135	0.3334	0.5204	0.3542	AKT2/PLCG2/PIP5K1A/ADCY7/CYTH3/PIP5K1B/ADCY6/SYK/CYTH1/DGKQ/PLA2G4A/PIK3CB/EGFR/KITLG/PIK3R5/GRM4/AGPAT3/AVP/RHEB/AGT/PLA2G4C/NRAS/PIK3R1/PIK3CA/F2R/ADCY8/AVPR2/LPAR6/RRAS/ARF6/PDGFC/MAPK1/PDGFA/SHC1/DGKA/ADCY1	36
KEGG	hsa01240	Biosynthesis of cofactors	37/1836	153/8135	0.345	0.5359	0.3648	GGH/ALAS1/GCH1/PANK2/MAT2A/NME6/RDH11/KMO/IDO1/TPK1/BCAT2/MAT2B/CPOX/UGT2B17/PNPO/HPD/ALPI/COQ7/NADK/HAAO/PPCS/KYNU/TDO2/RFK/AKR1A1/PDXK/GSS/MOCS2/ALAD/UGT2A3/NFS1/SHMT1/UGT2B4/FPGS/PPCDC/OXSM/COX15	37
KEGG	hsa04726	Serotonergic synapse	28/1836	115/8135	0.3577	0.5531	0.3765	PRKACB/DUSP1/GNAI3/PRKCB/CACNA1B/ALOX12B/APP/PLA2G4A/ITPR2/HTR6/KCNN2/CASP3/GNG3/ARAF/ITPR1/PLA2G4C/NRAS/CACNA1S/PRKACA/CYP2D6/KCND2/PTGS2/GNB3/PRKCG/CYP2C9/ITPR3/PRKACG/MAPK1	28
KEGG	hsa05231	Choline metabolism in cancer	24/1836	98/8135	0.3613	0.5561	0.3785	AKT2/MAPK9/PIP5K1A/CHKA/PRKCB/JUN/PIP5K1B/DGKQ/PLA2G4A/PIK3CB/EGFR/RHEB/PLA2G4C/NRAS/PIK3R1/PIK3CA/RAC2/FOS/SLC22A1/PDGFC/PRKCG/MAPK1/PDGFA/DGKA	24
KEGG	hsa00790	Folate biosynthesis	7/1836	26/8135	0.3686	0.5636	0.3837	GGH/GCH1/ALPI/TH/MOCS2/AKR1B10/FPGS	7
KEGG	hsa04922	Glucagon signaling pathway	26/1836	107/8135	0.3696	0.5636	0.3837	AKT2/PRKACB/PGAM1/ITPR2/CREBBP/PPP3CC/ITPR1/G6PC3/ACACB/PHKB/GCK/PRKACA/GCGR/CALM1/LDHAL6B/PRKAA2/SLC2A2/PRKAB2/CAMK2B/PHKG1/PPP3CB/ITPR3/PRKACG/CALML3/PHKA1/GYS1	26
KEGG	hsa05020	Prion disease	64/1836	273/8135	0.3862	0.5857	0.3987	PRKACB/CCL5/MAPK14/MAPK9/NDUFA9/GRIN2C/EGR1/VDAC3/NDUFS3/CACNA1B/RYR1/C7/NCF1/PSMC2/NDUFS1/PIK3CB/PSMD3/C8G/ITPR2/CASP3/NDUFS7/PPP3CC/PSMA5/ITPR1/TUBA8/TUBB/KLC1/PIK3R1/PIK3CA/RAC2/NCF4/PSMD8/PSMB5/CACNA1S/PRKCD/PSMB2/HSPA1L/PSMA4/TUBB2A/SDHA/TUBA1A/PRKACA/CYBA/NDUFA8/MAPK13/PPIF/PSMA2/SLC25A31/PSMD4/NDUFB3/COX6A2/PPP3CB/PSMB7/PSMB4/ITPR3/TUBA1B/CYBB/KIF5C/PRKACG/MAPK1/C6/NDUFB5/UQCRC1/SLC25A4	64
KEGG	hsa04146	Peroxisome	20/1836	82/8135	0.3876	0.5857	0.3987	MVK/FAR2/ACSL5/PEX11B/DECR2/PEX2/PEX5/IDH2/GNPAT/ACSL6/PEX26/HAO2/PEX3/GSTK1/MPV17/ACSL3/PEX12/PAOX/PEX1/ACOX3	20
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1836	14/8135	0.3922	0.59	0.4017	FUT8/B3GNT2/B4GALT2/B4GALT1	4
KEGG	hsa04080	Neuroactive ligand-receptor interaction	82/1836	353/8135	0.4019	0.6019	0.4097	GRIN2C/GZMA/PTGER1/VIPR2/CHRNE/EDNRB/TACR2/GALR1/NR3C1/ADRA2B/P2RX6/LTB4R/NPFFR1/CHRNG/SSTR3/HTR6/ADM2/UTS2/PENK/CSH1/SLURP1/ADORA1/GRM4/AVP/CNR1/AGT/CHRNA5/GALR3/EDN2/GIPR/SSTR1/OPRL1/P2RY2/FSHB/F2R/DRD3/S1PR5/PRSS2/CALCA/P2RY6/HCRT/OPRM1/GHSR/ADORA3/AVPR2/GNRHR/GABRR1/CRH/PARD3/GCGR/F2RL2/HRH3/SCT/ADCYAP1R1/P2RY10/SSTR2/GNRH2/CHRNB1/P2RX2/PTH1R/UCN/THRA/LPAR6/NTSR1/POMC/GHRH/GAL/CTSG/OPRD1/SSTR4/MTNR1B/HRH1/OPRK1/GIP/HRH2/NTSR2/P2RX1/SSTR5/CHRND/ADM/PLG/GABRR2	82
KEGG	hsa04962	Vasopressin-regulated water reabsorption	11/1836	44/8135	0.4063	0.6058	0.4124	PRKACB/ADCY6/RAB11A/AQP2/AVP/ARHGDIB/DYNC1I2/PRKACA/AVPR2/ARHGDIA/PRKACG	11
KEGG	hsa05134	Legionellosis	14/1836	57/8135	0.4093	0.6075	0.4136	EEF1A1/HSF1/SEC22B/CASP1/ITGB2/NFKB2/CASP3/CR1/IL18/HSPA1L/NFKB1/CD14/MYD88/PYCARD	14
KEGG	hsa00260	Glycine, serine and threonine metabolism	10/1836	40/8135	0.4159	0.6147	0.4185	ALAS1/BPGM/PGAM1/SARDH/SDS/SRR/GLDC/SHMT1/GATM/GNMT	10
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1836	53/8135	0.4183	0.6155	0.419	PRKACB/PRKCB/ADCY6/RAB11A/ATP2B4/PRKACA/ATP1B3/TRPV5/PTH1R/ATP1B2/PRKCG/PRKACG/CLTC	13
KEGG	hsa00350	Tyrosine metabolism	9/1836	36/8135	0.4265	0.6188	0.4213	GOT2/FAH/PNMT/ALDH3A1/HPD/HGD/MIF/TYRP1/TH	9
KEGG	hsa00512	Mucin type O-glycan biosynthesis	9/1836	36/8135	0.4265	0.6188	0.4213	GALNT10/GCNT1/C1GALT1C1/GALNT6/ST6GALNAC4/ST6GALNAC2/C1GALT1/GALNT8/GCNT3	9
KEGG	hsa00565	Ether lipid metabolism	12/1836	49/8135	0.428	0.6188	0.4213	GAL3ST1/PLA2G2D/PAFAH1B1/PAFAH1B3/PLA2G4A/LPCAT4/PLA2G2E/PLA2G4C/PLA2G6/GDPD3/PLA2G7/PLA2G12A	12
KEGG	hsa05030	Cocaine addiction	12/1836	49/8135	0.428	0.6188	0.4213	PRKACB/GNAI3/GRIN2C/JUN/FOSB/CDK5/SLC6A3/NFKB1/PRKACA/TH/PRKACG/BDNF	12
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1836	24/8135	0.4657	0.6694	0.4557	HS6ST1/EXTL1/EXTL3/HS2ST1/HS3ST3A1/GLCE	6
KEGG	hsa04530	Tight junction	39/1836	169/8135	0.467	0.6694	0.4557	PRKACB/RAB8A/MAP2K7/PCNA/MAPK9/EZR/PRKCZ/PPP2CB/LLGL2/ACTR2/JUN/STK11/ARPC5/YBX3/MYL6/ARHGEF18/RAP2C/RAPGEF6/MPP5/PPP2R1A/TUBA8/CLDN11/PRKCE/TUBA1A/PRKACA/ACTR3/PARD3/MAGI1/CD1D/PRKAA2/PRKAB2/PPP2CA/MAP3K5/ROCK1/MYH14/SYNPO/TUBA1B/PRKACG/ARHGAP17	39
KEGG	hsa05410	Hypertrophic cardiomyopathy	21/1836	90/8135	0.472	0.6737	0.4586	ITGB4/SGCA/ITGA7/ITGA4/MYBPC3/CACNG2/EMD/TGFB2/CACNG1/ITGB3/AGT/MYL3/TPM3/ITGB7/CACNA1S/ATP2A3/PRKAA2/PRKAB2/LAMA2/ATP2A1/DAG1	21
KEGG	hsa04371	Apelin signaling pathway	32/1836	139/8135	0.4823	0.6854	0.4666	AKT2/PRKACB/GNAI3/EGR1/ADCY7/RYR1/ADCY6/ITPR2/PIK3R5/GNG3/ITPR1/NRAS/MYL3/LIPE/PRKCE/TFAM/ADCY8/SMAD2/PRKACA/RPS6/CALM1/PRKAA2/PRKAB2/RRAS/GNB3/ITPR3/PRKACG/MAPK1/CALML3/MEF2D/SPP1/ADCY1	32
KEGG	hsa04723	Retrograde endocannabinoid signaling	34/1836	148/8135	0.4853	0.6868	0.4675	PRKACB/MAPK14/MAPK9/NDUFA9/GNAI3/PRKCB/ADCY7/NDUFS3/CACNA1B/ADCY6/NDUFS1/ITPR2/GNG3/DAGLA/NDUFS7/ITPR1/CNR1/FAAH/CACNA1S/ADCY8/PRKACA/GABRR1/NDUFA8/PTGS2/MAPK13/NDUFB3/GNB3/PRKCG/ITPR3/PRKACG/MAPK1/NDUFB5/GABRR2/ADCY1	34
KEGG	hsa00591	Linoleic acid metabolism	7/1836	29/8135	0.4915	0.6927	0.4715	PLA2G2D/PLA2G4A/PLA2G2E/PLA2G4C/PLA2G6/PLA2G12A/CYP2C9	7
KEGG	hsa05032	Morphine addiction	21/1836	91/8135	0.4948	0.6943	0.4727	PRKACB/GNAI3/PDE1B/PRKCB/ADCY7/CACNA1B/ADCY6/GNG3/ADORA1/OPRM1/ADCY8/PRKACA/GRK6/GABRR1/PDE4B/GNB3/PRKCG/PRKACG/PDE8A/GABRR2/ADCY1	21
KEGG	hsa00360	Phenylalanine metabolism	4/1836	16/8135	0.5038	0.6984	0.4755	GOT2/ALDH3A1/HPD/MIF	4
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/1836	16/8135	0.5038	0.6984	0.4755	ADO/GAD2/FMO1/FMO4	4
KEGG	hsa05168	Herpes simplex virus 1 infection	112/1836	495/8135	0.5061	0.6984	0.4755	AKT2/IRF9/JAK2/IFIH1/FAS/BCL2L1/TAP1/SOCS3/STAT1/CCL5/BIRC3/OAS2/ZNF430/ZNF544/TAB2/ZNF43/HLA-DOB/TLR3/ZNF764/ZNF141/ZNF529/ZNF419/ZNF45/ZNF253/TRAF6/ZNF557/SYK/ZNF107/ZNF780B/HLA-F/TAPBP/ZNF3/ZNF257/ZNF426/ZNF14/PIK3CB/HLA-DMB/ZNF200/PPP1CA/DDX58/TRAF3/ZNF324/ZNF180/ZNF85/CASP3/TBK1/RNASEL/OAS1/IFNAR1/HLA-C/ZNF682/ZNF112/HLA-DPA1/TRAF5/ZNF160/ZNF184/NXF3/RHEB/ITGB3/BAK1/IFNA1/ZNF471/PIK3R1/PIK3CA/HLA-DPB1/HLA-G/MAP3K7/IFNGR2/ZNF214/ZNF195/HLA-DMA/IRF7/POU2F3/IFNG/ZNF304/ZNF606/JAK1/ZNF211/ZNF205/ZNF813/FADD/ZNF331/TNFRSF1A/NFKB1/ZNF415/ZNF267/ZNF562/ZNF324B/ZNF468/OAS3/ZNF154/HLA-A/EIF2AK1/FASLG/TP53/CD74/ZNF667/IFNAR2/MYD88/ZNF814/TRADD/HLA-DRA/ZNF93/EIF2B2/ZNF33B/ZNF671/EIF2AK2/ZNF354A/IRAK4/ZNF549/B2M/IFNA5	112
KEGG	hsa04340	Hedgehog signaling pathway	13/1836	56/8135	0.5061	0.6984	0.4755	PRKACB/CSNK1G3/IQCE/FBXW11/CSNK1D/CSNK1G2/SHH/CDON/IHH/GLI1/MEGF8/PRKACA/PRKACG	13
KEGG	hsa05415	Diabetic cardiomyopathy	46/1836	203/8135	0.5155	0.7085	0.4823	AKT2/MAPK14/MAPK9/TGFBR2/NDUFA9/PRKCZ/PARP1/VDAC3/PRKCB/PDK3/NDUFS3/NCF1/NDUFS1/PIK3CB/PPP1CA/TGFB2/NDUFS7/AGT/PIK3R1/PIK3CA/RAC2/NCF4/PRKCD/ATP2A3/NFKB1/SDHA/SMAD2/PDK2/CYBA/NDUFA8/MAPK13/PPIF/TBC1D4/SLC25A31/CAMK2B/NDUFB3/COX6A2/SLC2A4/PRKCG/COL3A1/ATP2A1/CYBB/NDUFB5/UQCRC1/SLC25A4/GYS1	46
KEGG	hsa00600	Sphingolipid metabolism	12/1836	52/8135	0.5192	0.7101	0.4834	CERK/GAL3ST1/SGPP1/CERS6/SGPL1/SPTLC3/SMPD2/CERS4/SMPD1/NEU2/B4GALT6/HEXB	12
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	34/1836	150/8135	0.5209	0.7101	0.4834	AKT2/PRKACB/MAPK14/GNAI3/PPP2CB/ADCY7/ADCY6/CACNG2/PPP1CA/PIK3R5/PPP2R1A/CACNG1/RPS6KA5/AGT/PPP2R5C/MYL3/TPM3/CACNA1S/ATP2B4/ATP2A3/ADCY8/PRKACA/ATP1B3/CALM1/MAPK13/PPP2CA/CAMK2B/ATP1B2/SCN1B/ATP2A1/PRKACG/MAPK1/CALML3/ADCY1	34
KEGG	hsa00030	Pentose phosphate pathway	7/1836	30/8135	0.531	0.7181	0.4888	H6PD/TKT/DERA/GPI/TALDO1/ALDOC/PRPS2	7
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1836	30/8135	0.531	0.7181	0.4888	HAO2/GLDC/HYI/GLUL/MDH1/SHMT1/PGP	7
KEGG	hsa04918	Thyroid hormone synthesis	17/1836	75/8135	0.5372	0.7235	0.4925	PRKACB/PRKCB/ADCY7/ADCY6/ITPR2/ITPR1/GPX3/PDIA4/ADCY8/PRKACA/ASGR1/ATP1B3/ATP1B2/PRKCG/ITPR3/PRKACG/ADCY1	17
KEGG	hsa00450	Selenocompound metabolism	4/1836	17/8135	0.5561	0.7459	0.5078	PAPSS1/PAPSS2/TXNRD2/SEPHS1	4
KEGG	hsa00010	Glycolysis / Gluconeogenesis	15/1836	67/8135	0.5621	0.7509	0.5112	BPGM/PGAM1/ADPGK/ENO1/ALDH3A1/GPI/MINPP1/TPI1/ENO2/ENO3/G6PC3/GCK/AKR1A1/LDHAL6B/ALDOC	15
KEGG	hsa00220	Arginine biosynthesis	5/1836	22/8135	0.5757	0.7661	0.5215	GOT2/ASL/GLUD1/GLUL/OTC	5
KEGG	hsa05014	Amyotrophic lateral sclerosis	81/1836	364/8135	0.5799	0.7662	0.5216	BCL2L1/RAB8A/FIG4/HDAC6/HAP1/MAPK14/NDUFA9/GRIN2C/SPG11/FUS/NUP37/TPR/CASP1/ATG2B/OPTN/NDUFS3/ACTR10/PSMC2/NDUFS1/DNAL4/PSMD3/TOMM40/NXT2/POM121C/SQSTM1/TNFRSF1B/CASP3/TBK1/POM121/NDUFS7/SETX/PPP3CC/DNAH9/PSMA5/NXF3/TUBA8/TUBB/KLC1/PSMD8/DNAH17/NUP133/PSMB5/GPX3/PSMB2/ATG13/PSMA4/WIPI1/TUBB2A/TNFRSF1A/SDHA/TUBA1A/NDUFA8/NUP107/DCTN3/TP53/MAPK13/SEC13/ATXN2L/XBP1/PSMA2/PSMD4/MAP3K5/NDUFB3/COX6A2/ULK1/PPP3CB/NUP93/NDC1/PSMB7/HNRNPA1/PSMB4/ITPR3/TUBA1B/KIF5C/NDUFB5/UQCRC1/NUP210/DNAH6/NUP205/NUP85/ERN1	81
KEGG	hsa02010	ABC transporters	10/1836	45/8135	0.5804	0.7662	0.5216	TAP1/ABCC4/ABCG1/ABCC10/ABCA2/ABCB1/ABCG4/ABCB9/ABCA8/ABCC8	10
KEGG	hsa00500	Starch and sucrose metabolism	8/1836	36/8135	0.5848	0.769	0.5235	GYG1/AGL/GPI/GBA3/G6PC3/GCK/ENPP1/GYS1	8
KEGG	hsa03450	Non-homologous end-joining	3/1836	13/8135	0.5896	0.77	0.5242	XRCC4/FEN1/DNTT	3
KEGG	hsa04613	Neutrophil extracellular trap formation	42/1836	190/8135	0.5902	0.77	0.5242	AKT2/PLCG2/HDAC6/MAPK14/HDAC3/VDAC3/PRKCB/CASP1/TLR8/SYK/ITGB2/NCF1/PIK3CB/HAT1/GSDMD/HDAC7/TLR7/ELANE/ITGB3/CR1/PIK3R1/PIK3CA/MAP3K7/RAC2/NCF4/AZU1/CAMP/NFKB1/CYBA/ITGAL/MAPK13/PPIF/HDAC1/FGG/SLC25A31/CTSG/PRKCG/CYBB/MAPK1/SLC25A4/HDAC11/ATG7	42
KEGG	hsa04979	Cholesterol metabolism	11/1836	50/8135	0.5936	0.7714	0.5251	APOA1/LRP1/LDLR/VDAC3/CYP27A1/LCAT/LDLRAP1/APOA2/ANGPTL4/SORT1/APOA4	11
KEGG	hsa04724	Glutamatergic synapse	25/1836	114/8135	0.6019	0.7792	0.5305	PRKACB/GNAI3/GRIN2C/PRKCB/ADCY7/ADCY6/PLA2G4A/ITPR2/GNG3/PPP3CC/SLC38A3/GRM4/SLC1A1/ITPR1/PLA2G4C/GLUL/ADCY8/PRKACA/GNB3/PPP3CB/PRKCG/ITPR3/PRKACG/MAPK1/ADCY1	25
KEGG	hsa00511	Other glycan degradation	4/1836	18/8135	0.6053	0.7805	0.5314	AGA/MAN2B1/NEU2/HEXB	4
KEGG	hsa04721	Synaptic vesicle cycle	17/1836	78/8135	0.6093	0.7828	0.5329	ATP6V1D/ATP6V0E1/CACNA1B/ATP6V1H/ATP6V1A/SLC1A1/ATP6V1E1/SLC18A3/SLC6A11/SLC6A3/SLC6A9/CPLX3/STX1A/SLC6A7/TCIRG1/CPLX2/CLTC	17
KEGG	hsa01250	Biosynthesis of nucleotide sugars	8/1836	37/8135	0.6186	0.7916	0.5389	UXS1/NAGK/FPGT/GPI/GALK2/CMAS/TGDS/GCK	8
KEGG	hsa00270	Cysteine and methionine metabolism	11/1836	51/8135	0.6223	0.7933	0.54	DNMT1/GOT2/MAT2A/BCAT2/MAT2B/APIP/SDS/BHMT2/LDHAL6B/GSS/MDH1	11
KEGG	hsa03015	mRNA surveillance pathway	21/1836	97/8135	0.6256	0.7945	0.5409	CPSF1/FUS/UPF1/PPP2CB/GSPT2/RNGTT/NXT2/PPP1CA/PPP2R1A/CLP1/NXF3/PPP2R5C/CSTF1/PAPOLA/PABPC3/PABPC1/PPP2CA/PAPOLG/UPF3B/MSI1/WDR82	21
KEGG	hsa00380	Tryptophan metabolism	9/1836	42/8135	0.6299	0.797	0.5425	HADHA/KMO/IDO1/DHTKD1/DLST/HAAO/KYNU/TDO2/CYP1B1	9
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	46/1836	212/8135	0.6474	0.8159	0.5554	AKT2/JAK2/PRKACB/GNAI3/RXRB/PRKCB/ADCY7/JUN/UGT2B17/CACNA1B/ADCY6/CDC6/RPS6KA1/AR/HSP90AA1/PIK3CB/EGFR/KLF4/STAT5A/MYC/CCND3/NRAS/PIK3R1/PIK3CA/BCL6/CACNA1S/FGF17/NFKB1/ADCY8/PRKACA/TNFSF11/RXRG/FOS/FGF5/CYP1B1/FGF3/UGT2A3/BIRC5/PRKCG/PRKACG/MAPK1/AHR/UGT2B4/RXRA/XIAP/ADCY1	46
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1836	19/8135	0.651	0.8174	0.5564	IDH3B/GOT2/BCAT2/IDH2	4
KEGG	hsa00860	Porphyrin metabolism	9/1836	43/8135	0.66	0.8225	0.5599	ALAS1/CPOX/UGT2B17/BLVRA/ALAD/UGT2A3/HMOX1/UGT2B4/COX15	9
KEGG	hsa04975	Fat digestion and absorption	9/1836	43/8135	0.66	0.8225	0.5599	APOA1/GOT2/PLA2G2D/CEL/PLA2G2E/FABP1/PLA2G12A/APOA4/DGAT1	9
KEGG	hsa04610	Complement and coagulation cascades	18/1836	85/8135	0.6626	0.8227	0.5601	F7/C7/ITGB2/F10/C8G/MASP1/F9/CR1/PROS1/F2R/F12/F2RL2/FGG/CFB/F11/CR2/C6/PLG	18
KEGG	hsa04714	Thermogenesis	50/1836	232/8135	0.6717	0.8309	0.5657	PRKACB/FGFR1/MAPK14/ACSL5/NDUFA9/ARID1A/ADCY7/PNPLA2/KDM3A/FGF21/NDUFS3/ADCY6/DPF1/RPS6KA1/NDUFS1/SMARCA4/FRS2/COA7/ACSL6/NDUFS7/PRDM16/CNR1/RHEB/SLC25A20/NRAS/NDUFAF1/LIPE/NPPB/PRKG1/SDHA/ADCY8/ACSL3/PRKACA/NDUFA8/RPS6/MAPK13/BMP8A/PRKAA2/PRKAB2/MAP3K5/NDUFB3/COA1/COX6A2/PRKACG/NDUFB5/UQCRC1/COX15/PPARG/ADCY1/SMARCD3	50
KEGG	hsa03020	RNA polymerase	7/1836	34/8135	0.6743	0.831	0.5657	POLR2F/CRCP/POLR1B/POLR3B/POLR3G/POLR2E/POLR3K	7
KEGG	hsa00230	Purine metabolism	27/1836	128/8135	0.6896	0.8467	0.5764	NME6/CANT1/RRM2/ENTPD1/PDE1B/ENTPD2/DCK/ADCY7/PAPSS1/ADCY6/PAPSS2/AMPD1/PDE6D/AMPD3/ATIC/GMPR2/ADCY8/GUCY2D/PDE4B/GMPR/RRM1/ENPP1/PRPS2/ADA/DGUOK/PDE8A/ADCY1	27
KEGG	hsa00730	Thiamine metabolism	3/1836	15/8135	0.692	0.8467	0.5764	TPK1/ALPI/NFS1	3
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/1836	30/8135	0.7006	0.854	0.5814	IDH3B/OGDHL/IDH2/DLST/SDHA/MDH1	6
KEGG	hsa04512	ECM-receptor interaction	18/1836	88/8135	0.7225	0.877	0.597	COL6A1/ITGB4/SDC1/HMMR/ITGA7/ITGA4/TNXB/LAMC3/ITGB3/FN1/ITGB7/COL4A3/GP9/THBS2/LAMA2/HSPG2/SPP1/DAG1	18
KEGG	hsa03018	RNA degradation	16/1836	79/8135	0.7306	0.877	0.597	DCPS/ENO1/PARN/TTC37/DCP2/EDC3/LSM1/TOB2/ENO2/ENO3/EXOSC2/CNOT1/BTG2/CNOT2/PABPC3/PABPC1	16
KEGG	hsa00410	beta-Alanine metabolism	6/1836	31/8135	0.7321	0.877	0.597	HADHA/ALDH3A1/HIBCH/GAD2/CNDP2/ACOX3	6
KEGG	hsa00564	Glycerophospholipid metabolism	20/1836	98/8135	0.7334	0.877	0.597	CHKA/PLA2G2D/CDS2/ETNK1/GNPAT/DGKQ/PLA2G4A/PNPLA6/LPCAT4/PEMT/AGPAT3/LCAT/PLA2G2E/PLA2G4C/PLA2G6/CHAT/PTDSS1/PLA1A/PLA2G12A/DGKA	20
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	7/1836	36/8135	0.7345	0.877	0.597	CD38/SIRT5/SIRT7/NNT/NADK/NMRK1/ENPP1	7
KEGG	hsa05016	Huntington disease	65/1836	306/8135	0.7352	0.877	0.597	MAP2K7/HAP1/MAPK9/POLR2F/NDUFA9/VDAC3/ATG2B/NDUFS3/CACNA1B/ACTR10/PSMC2/NDUFS1/DNAL4/PSMD3/CASP3/CREBBP/NDUFS7/DNAH9/PSMA5/ITPR1/TUBA8/TUBB/MAP3K10/KLC1/PSMD8/DNAH17/PSMB5/GPX3/PSMB2/ATG13/PSMA4/WIPI1/TFAM/HIP1/TUBB2A/SDHA/TUBA1A/NDUFA8/POLR2E/DCTN3/STX1A/TP53/PPIF/HDAC1/PSMA2/SLC25A31/PSMD4/MAP3K5/NDUFB3/COX6A2/ULK1/RCOR1/PSMB7/PSMB4/TUBA1B/KIF5C/NDUFB5/TBP/UQCRC1/BDNF/SLC25A4/DNAH6/CLTC/PPARG/ERN1	65
KEGG	hsa04974	Protein digestion and absorption	21/1836	103/8135	0.7385	0.8778	0.5976	SLC7A8/COL6A1/SLC3A2/KCNN4/COL8A1/COL14A1/MEP1B/SLC1A1/COL4A3/PRSS2/COL17A1/SLC1A5/COL11A2/CELA2B/ATP1B3/CPA1/KCNK5/COL19A1/ATP1B2/CELA3A/COL3A1	21
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1836	11/8135	0.7479	0.8858	0.603	HPD/COQ7	2
KEGG	hsa00590	Arachidonic acid metabolism	12/1836	61/8135	0.7524	0.8869	0.6038	PLA2G2D/HPGDS/ALOX12B/PLA2G4A/PLA2G2E/PLA2G4C/PLA2G6/GPX3/PTGS2/CBR3/PLA2G12A/CYP2C9	12
KEGG	hsa01232	Nucleotide metabolism	17/1836	85/8135	0.7542	0.8869	0.6038	NME6/CANT1/RRM2/ENTPD1/ENTPD2/DCK/TYMS/AMPD1/AMPD3/GMPR2/GMPR/RRM1/DCTD/ENPP1/ASMTL/ADA/DGUOK	17
KEGG	hsa00062	Fatty acid elongation	5/1836	27/8135	0.7623	0.8913	0.6067	HADHA/ACOT7/MECR/ELOVL2/ELOVL4	5
KEGG	hsa04973	Carbohydrate digestion and absorption	9/1836	47/8135	0.7649	0.8913	0.6067	AKT2/PRKCB/PIK3CB/PIK3R1/PIK3CA/G6PC3/ATP1B3/SLC2A2/ATP1B2	9
KEGG	hsa00340	Histidine metabolism	4/1836	22/8135	0.7658	0.8913	0.6067	ALDH3A1/CNDP2/HDC/FTCD	4
KEGG	hsa01212	Fatty acid metabolism	11/1836	57/8135	0.77	0.8929	0.6079	ACSL5/HADHA/ACSL6/FASN/MECR/ACSL3/ELOVL2/ELOVL4/ACOX3/OXSM/HSD17B8	11
KEGG	hsa00120	Primary bile acid biosynthesis	3/1836	17/8135	0.7739	0.8944	0.6089	CYP7B1/CYP27A1/SLC27A5	3
KEGG	hsa05150	Staphylococcus aureus infection	19/1836	96/8135	0.779	0.8972	0.6107	FCGR2B/HLA-DOB/KRT33A/ITGB2/HLA-DMB/MASP1/DEFA6/HLA-DPA1/HLA-DPB1/KRT32/HLA-DMA/CAMP/ITGAL/FGG/CFB/HLA-DRA/KRT13/IL10/PLG	19
KEGG	hsa05100	Bacterial invasion of epithelial cells	15/1836	77/8135	0.7819	0.8975	0.611	ELMO1/ACTR2/PXN/CTNNB1/ARPC5/PIK3CB/WASL/FN1/PIK3R1/PIK3CA/CTNNA1/ACTR3/CD2AP/SHC1/CLTC	15
KEGG	hsa00480	Glutathione metabolism	11/1836	58/8135	0.7901	0.9022	0.6142	LAP3/RRM2/HPGDS/IDH2/NAT8B/GSTK1/GPX3/PRDX6/GPX4/RRM1/GSS	11
KEGG	hsa00515	Mannose type O-glycan biosynthesis	4/1836	23/8135	0.7968	0.9022	0.6142	FUT4/B4GALT2/B4GALT1/POMGNT1	4
KEGG	hsa03060	Protein export	4/1836	23/8135	0.7968	0.9022	0.6142	SEC63/SPCS1/SPCS2/SPCS3	4
KEGG	hsa04614	Renin-angiotensin system	4/1836	23/8135	0.7968	0.9022	0.6142	PREP/AGT/ATP6AP2/CTSG	4
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1836	49/8135	0.8078	0.9116	0.6205	UXS1/NAGK/FPGT/GPI/GALK2/CMAS/CYB5R4/GCK/HEXB	9
KEGG	hsa04744	Phototransduction	5/1836	29/8135	0.8168	0.9186	0.6253	GRK1/GUCY2D/CALM1/GNAT1/CALML3	5
KEGG	hsa00531	Glycosaminoglycan degradation	3/1836	19/8135	0.837	0.9381	0.6386	IDS/HEXB/HPSE	3
KEGG	hsa04742	Taste transduction	16/1836	86/8135	0.845	0.9439	0.6426	PRKACB/PDE1B/ENTPD2/ADCY6/PKD2L1/GRM4/ADCY8/PRKACA/P2RX2/SCN3A/KCNK5/SCN9A/GNB3/ITPR3/PRKACG/TAS2R16	16
KEGG	hsa00052	Galactose metabolism	5/1836	31/8135	0.8608	0.957	0.6515	B4GALT2/G6PC3/GCK/B4GALT1/AKR1B10	5
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1836	20/8135	0.8624	0.957	0.6515	UST/DSE/CHST3	3
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/1836	223/8135	0.8672	0.959	0.6529	AKT2/MAP2K7/MAPK14/MAPK9/NDUFA9/VDAC3/JUN/NDUFS3/PRKD2/NCF1/NDUFS1/SLC26A1/PIK3CB/MAP2K4/EGFR/NDUFS7/ARAF/NRAS/PIK3R1/PIK3CA/NOX1/PRKCD/NFKB1/SDHA/PTPN1/CYBA/NDUFA8/FOS/AKR1A1/MAPK13/PPIF/FOXO3/SLC25A31/CYP1B1/MAP3K5/NDUFB3/COX6A2/NOX4/MAPK1/HMOX1/AHR/NDUFB5/UQCRC1/SLC25A4	44
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/1836	37/8135	0.8722	0.9595	0.6532	GOT2/ASL/GLUD1/GLUL/GAD2/ALDH4A1	6
KEGG	hsa00240	Pyrimidine metabolism	10/1836	58/8135	0.8733	0.9595	0.6532	NME6/CANT1/RRM2/ENTPD1/DCK/TYMS/RRM1/DCTD/ENPP1/ASMTL	10
KEGG	hsa00640	Propanoate metabolism	5/1836	32/8135	0.8793	0.9629	0.6555	HADHA/HIBCH/ACACB/LDHAL6B/ACOX3	5
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/1836	27/8135	0.8891	0.9705	0.6606	ACOT7/ELOVL2/ELOVL4/ACOX3	4
KEGG	hsa00051	Fructose and mannose metabolism	5/1836	33/8135	0.8956	0.9743	0.6633	FPGT/TPI1/ALDOC/AKR1B10/PFKFB4	5
KEGG	hsa04978	Mineral absorption	10/1836	60/8135	0.8985	0.9743	0.6633	ATOX1/STEAP1/FTL/SLC30A1/ATP2B4/TRPV6/ATP1B3/ATP1B2/HMOX1/SLC31A1	10
KEGG	hsa00140	Steroid hormone biosynthesis	10/1836	61/8135	0.9094	0.9804	0.6674	SRD5A1/HSD17B1/UGT2B17/CYP7B1/CYP17A1/CYP1B1/UGT2A3/UGT2B4/SRD5A2/HSD17B8	10
KEGG	hsa00040	Pentose and glucuronate interconversions	5/1836	34/8135	0.91	0.9804	0.6674	UGT2B17/AKR1A1/UGT2A3/AKR1B10/UGT2B4	5
KEGG	hsa04392	Hippo signaling pathway - multiple species	4/1836	29/8135	0.9196	0.9877	0.6723	RASSF2/PAK1/WWTR1/FRMD1	4
KEGG	hsa00830	Retinol metabolism	11/1836	68/8135	0.9257	0.991	0.6746	RDH16/RDH11/UGT2B17/CYP2W1/RPE65/DHRS9/UGT2A3/CYP2C9/UGT2B4/DGAT1/ALDH1A2	11
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/1836	30/8135	0.9319	0.9944	0.6769	UGT2B17/AKR1A1/UGT2A3/UGT2B4	4
KEGG	hsa00561	Glycerolipid metabolism	9/1836	61/8135	0.9533	1	0.6807	PNPLA2/DGKQ/CEL/PNPLA3/AGPAT3/AKR1A1/AKR1B10/DGAT1/DGKA	9
KEGG	hsa00330	Arginine and proline metabolism	7/1836	51/8135	0.9606	1	0.6807	LAP3/GOT2/SAT1/P4HA1/CNDP2/ALDH4A1/GATM	7
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	10/1836	69/8135	0.9661	1	0.6807	NAT1/HPGDS/UGT2B17/GSTK1/PTGS2/CYP1B1/UGT2A3/CYP2C9/UGT2B4/CYP2A13	10
KEGG	hsa04260	Cardiac muscle contraction	13/1836	87/8135	0.9719	1	0.6807	SLC9A6/ASPH/CACNG2/CACNG1/MYL3/TPM3/CACNA1S/ATP2A3/ATP1B3/COX6A2/ATP1B2/ATP2A1/UQCRC1	13
KEGG	hsa00982	Drug metabolism - cytochrome P450	10/1836	72/8135	0.9772	1	0.6807	HPGDS/UGT2B17/ALDH3A1/GSTK1/CYP2D6/FMO1/UGT2A3/CYP2C9/UGT2B4/FMO4	10
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1836	78/8135	0.9783	1	0.6807	HPGDS/UGT2B17/ALDH3A1/GSTK1/CYP2D6/CBR3/CYP1B1/UGT2A3/CYP2C9/UGT2B4/CYP2A13	11
KEGG	hsa00071	Fatty acid degradation	5/1836	43/8135	0.9787	1	0.6807	ACSL5/HADHA/ACSL6/ACSL3/ACOX3	5
KEGG	hsa03040	Spliceosome	23/1836	147/8135	0.9861	1	0.6807	FUS/DDX23/CRNKL1/HNRNPU/SF3B1/PPIE/DHX38/PRPF6/SNRNP70/CDC40/DDX46/PRPF18/THOC2/HNRNPK/HSPA1L/CTNNBL1/U2AF2/TRA2B/XAB2/PRPF8/HNRNPA1/PRPF19/BUD31	23
KEGG	hsa05033	Nicotine addiction	4/1836	40/8135	0.9885	1	0.6807	GRIN2C/CACNA1B/GABRR1/GABRR2	4
KEGG	hsa00620	Pyruvate metabolism	5/1836	47/8135	0.9894	1	0.6807	ACACB/ME1/AKR1A1/LDHAL6B/MDH1	5
KEGG	hsa03010	Ribosome	24/1836	158/8135	0.9924	1	0.6807	RPL37A/MRPL18/MRPL16/RPS23/RPL9/RPL35A/RPL41/RPS5/MRPL22/RPS4Y1/RPL39/MRPL13/MRPS14/RPL7/RPS28/RPL18/RPS6/RPL34/MRPL11/MRPS12/MRPL19/RPS21/RPL30/RPS9	24
KEGG	hsa00650	Butanoate metabolism	2/1836	28/8135	0.993	1	0.6807	HADHA/GAD2	2
KEGG	hsa00190	Oxidative phosphorylation	19/1836	134/8135	0.9948	1	0.6807	ATP6V1D/NDUFA9/ATP6V0E1/NDUFS3/ATP6V1H/NDUFS1/ATP6V1A/NDUFS7/ATP6V1E1/ATP6AP1/ATP4A/SDHA/NDUFA8/TCIRG1/NDUFB3/COX6A2/NDUFB5/UQCRC1/COX15	19
KEGG	hsa05206	MicroRNAs in cancer	52/1836	310/8135	0.9958	1	0.6807	PLCG2/DNMT1/ATM/EZR/CCNE2/PRKCB/STMN1/E2F3/FZD3/KIF23/TNXB/TIMP3/CDC25B/PIK3CB/EGFR/TGFB2/EZH2/CDKN1A/CCNE1/CASP3/CREBBP/CYP24A1/MYC/RPS6KA5/ITGB3/MCL1/BAK1/NRAS/PIK3R1/PIK3CA/ABCB1/HNRNPK/PRKCE/EFNA5/IRS2/NFKB1/MARCKS/CDKN1B/PTGS2/EFNA4/TP53/HDAC1/SERPINB5/CYP1B1/ROCK1/PRKCG/MAPK1/HMOX1/PDGFA/SHC1/BRCA1/MDM4	52
KEGG	hsa05034	Alcoholism	28/1836	187/8135	0.9967	1	0.6807	PRKACB/HDAC6/HDAC3/GNAI3/GRIN2C/SLC29A3/NTRK2/PKIA/HAT1/PPP1CA/HDAC7/FOSB/GNG3/ARAF/NRAS/SLC6A3/PRKACA/TH/CRH/CALM1/HDAC1/GNB3/PRKACG/MAPK1/CALML3/BDNF/HDAC11/SHC1	28
KEGG	hsa00280	Valine, leucine and isoleucine degradation	4/1836	48/8135	0.9975	1	0.6807	HADHA/BCAT2/HIBCH/IVD	4
KEGG	hsa05322	Systemic lupus erythematosus	18/1836	136/8135	0.998	1	0.6807	TRIM21/HLA-DOB/C7/CD86/HLA-DMB/C8G/CD40/ELANE/HLA-DPA1/CD40LG/HLA-DPB1/CD80/HLA-DMA/IFNG/HLA-DRA/CTSG/IL10/C6	18
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	6/1836	66/8135	0.9989	1	0.6807	FARS2/HARS2/FARSA/IARS2/QRSL1/NARS2	6
KEGG	hsa00983	Drug metabolism - other enzymes	8/1836	80/8135	0.999	1	0.6807	NAT1/NME6/RRM2/UGT2B17/RRM1/UGT2A3/UGT2B4/TPMT	8
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	11/1836	109/8135	0.9998	1	0.6807	POP5/RPP30/XPO1/POP4/NXT2/WDR43/NXF3/DROSHA/TCOF1/FCF1/IMP3	11
KEGG	hsa04740	Olfactory transduction	19/1836	440/8135	1	1	0.6807	PRKACB/PDE1B/OR7A17/OR1F1/OR10H1/OR3A3/OR3A1/OR2H2/NCALD/PRKG1/OR7A10/PRKACA/GUCY2D/OR10H2/CALM1/OR7C1/CAMK2B/PRKACG/CALML3	19