ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	71/1378	223/8135	2.366e-08	7.878e-06	5.18e-06	GSTA4/NFKBIA/EPHX1/MAP3K5/PRKD2/COX7A1/NDUFC1/MAPK3/SLC25A4/SDHC/EPHX2/NDUFA13/NDUFS4/NDUFA4L2/SOS1/HGF/BAD/EGFR/NDUFB4/EGF/NQO1/NDUFA4/UQCR10/NDUFA8/PRKD3/MGST3/GSTM4/PLD1/CYC1/COX6C/COX8A/NDUFA2/CAT/COX6A1/NDUFB6/NFKB1/NDUFB7/SDHD/MAPK11/CHUK/PIK3CB/NDUFB2/GSTM5/AKR1C3/NDUFA6/COX5B/GSTM3/NDUFA10/VEGFA/NDUFB11/SOD1/ACP1/HIF1A/NDUFB8/NDUFA3/UQCRQ/PIK3CD/IKBKG/RAF1/NDUFS3/VDAC3/NDUFS7/NDUFS6/CBR1/KRAS/AKR1C4/NDUFA1/UQCRC1/NRAS/PIK3CA/NCF1	71
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	69/1378	222/8135	1.079e-07	1.232e-05	8.101e-06	NFKBIA/IL15RA/HLA-C/HLA-DRB4/MAPK3/SLC25A4/SMAD3/IL15/HLA-F/IL2RG/CCNA2/HLA-G/HLA-A/ATR/CHEK2/CHEK1/ATM/CDKN2C/ITGAL/PTTG1/CDK4/HLA-B/HLA-E/CREB3/BUB1B/JAK1/CD40/NFKB1/CD3E/RELB/LCK/CCNB2/CHUK/PIK3CB/TSPO/TRRAP/MYC/IL2RB/CD3D/IL6/EGR1/ADCY1/CDC20/HLA-DOB/HLA-DQB1/PPP3CA/MAP3K3/KAT5/TLN2/PIK3CD/ADCY2/IKBKG/TCF3/CREB1/VDAC3/STAT5A/CCND2/KAT2B/CDKN1A/ATF2/EP300/CRTC3/CD3G/KRAS/ETS2/ATF4/PTTG2/NRAS/PIK3CA	69
KEGG	hsa04932	Non-alcoholic fatty liver disease	53/1378	155/8135	1.11e-07	1.232e-05	8.101e-06	CEBPA/MAP3K5/COX7A1/NDUFC1/FAS/SDHC/NDUFA13/NDUFS4/NDUFA4L2/NDUFB4/MAP3K11/NDUFA4/UQCR10/NDUFA8/GSK3B/INSR/PRKAG1/RXRA/PRKAB1/PPARG/CYC1/COX6C/COX8A/NDUFA2/COX6A1/NDUFB6/NFKB1/NDUFB7/SDHD/MAPK11/PIK3CB/NDUFB2/IL6/NDUFA6/COX5B/NDUFA10/NDUFB11/NDUFB8/PRKAA1/NDUFA3/UQCRQ/PIK3CD/IL6R/NDUFS3/NDUFS7/NDUFS6/XBP1/CXCL8/ATF4/NDUFA1/UQCRC1/DDIT3/PIK3CA	53
KEGG	hsa04660	T cell receptor signaling pathway	39/1378	104/8135	3.62e-07	2.526e-05	1.661e-05	NFKBIA/RASGRP1/MAPK3/MALT1/PTPRC/SOS1/CD8A/ITK/CTLA4/NCK2/GSK3B/CDK4/CD28/ZAP70/MAP3K8/NFKB1/CBLB/CD3E/IFNG/LCK/MAPK11/CHUK/PIK3CB/CD3D/CD247/PRKCQ/PPP3CA/LAT/PIK3CD/IKBKG/RAF1/PAK2/BCL10/CD3G/KRAS/LCP2/CD40LG/NRAS/PIK3CA	39
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	35/1378	89/8135	3.794e-07	2.526e-05	1.661e-05	NFKBIA/STAT1/JAK2/RASGRP1/MAPK3/EGFR/EGF/JAK1/CSNK2B/CD28/ZAP70/NFKB1/CD3E/IFNG/LCK/MAPK11/CHUK/PIK3CB/CD3D/CD247/PRKCQ/BATF/PPP3CA/MAP3K3/LAT/HIF1A/PIK3CD/IKBKG/RAF1/EML4/MYD88/CD3G/KRAS/NRAS/PIK3CA	35
KEGG	hsa04658	Th1 and Th2 cell differentiation	34/1378	92/8135	2.96e-06	0.0001643	0.000108	NFKBIA/NOTCH1/STAT1/JAK2/HLA-DRB4/MAPK3/IL2RG/IL4R/RUNX3/TYK2/JAK1/ZAP70/MAML1/NFKB1/STAT4/CD3E/IFNG/LCK/MAPK11/CHUK/IL2RB/CD3D/RBPJ/CD247/HLA-DOB/HLA-DQB1/PRKCQ/PPP3CA/LAT/JAG2/IKBKG/MAF/STAT5A/CD3G	34
KEGG	hsa05169	Epstein-Barr virus infection	60/1378	202/8135	3.845e-06	0.0001726	0.0001135	TNFAIP3/NFKBIA/TAP1/CXCL10/HLA-C/STAT1/HLA-DRB4/PLCG2/TBK1/HLA-F/FAS/CCNA2/HLA-G/HLA-A/TRAF5/ITGAL/RUNX3/CDK4/TYK2/HLA-B/HLA-E/JAK1/IRF3/PSMC2/CD40/TAPBP/CD44/NFKB1/CD3E/RELB/APAF1/MAPK11/CHUK/PIK3CB/PSMC3/MYC/CD3D/IL6/IRAK4/RBPJ/CD247/HLA-DOB/CD19/HLA-DQB1/CASP9/PSMD8/TAP2/TRAF3/DDB2/CD58/HDAC1/PIK3CD/IKBKG/CCND2/CDKN1A/OAS2/SAP30/MYD88/CD3G/PIK3CA	60
KEGG	hsa04010	MAPK signaling pathway	80/1378	294/8135	4.611e-06	0.0001726	0.0001135	CDC25B/DUSP5/MAP3K5/RASGRP1/MAPK3/PGF/ANGPT1/FAS/DUSP6/PRKCB/SOS1/HGF/EGFR/EGF/MAP3K11/ANGPT2/NTRK2/PTPN7/INSR/RASGRP3/NTF3/KIT/MAPK7/FGF20/ERBB2/EFNA5/GNG12/MAP4K1/ARRB1/MAP3K8/HSPB1/NFKB1/NTRK1/PLA2G4C/RELB/DAXX/MAPK11/CHUK/IGF1/FGF18/KDR/RAC2/MYC/HSPA6/TAOK1/MAP4K4/IRAK4/EREG/PDGFB/DUSP2/VEGFA/NLK/MAPKAPK2/PPP3CA/MAP3K3/PPM1B/CACNB2/MKNK2/TAOK3/CACNA1D/NGFR/IKBKG/RAF1/PAK2/ATF2/ERBB4/MYD88/RASGRP2/HSPA2/CACNA2D3/FLNA/KRAS/RPS6KA1/RAP1B/FGF5/ATF4/BDNF/DDIT3/VEGFB/NRAS	80
KEGG	hsa05170	Human immunodeficiency virus 1 infection	62/1378	212/8135	4.665e-06	0.0001726	0.0001135	NFKBIA/TAP1/HLA-C/TNFRSF1B/MAPK3/PLCG2/SKP1/TBK1/HLA-F/LIMK2/FAS/HLA-G/PRKCB/HLA-A/ATR/TRAF5/CHEK1/ATM/BAD/AP1B1/APOBEC3C/AP1G2/HLA-B/HLA-E/CCR5/SAMHD1/GNG3/GNG12/IRF3/TAPBP/CXCR4/NFKB1/CD3E/ITPR2/CCNB2/MAPK11/CHUK/PIK3CB/CCNB1/RAC2/CD3D/IRAK4/CD247/APOBEC3B/AP1S1/CASP9/TAP2/GNB2/PPP3CA/PIK3CD/IKBKG/RAF1/CDK1/PAK2/WEE1/MYD88/CD3G/KRAS/PTK2B/CALML4/NRAS/PIK3CA	62
KEGG	hsa04064	NF-kappa B signaling pathway	36/1378	104/8135	8.73e-06	0.0002907	0.0001911	TNFAIP3/NFKBIA/BIRC3/PLCG2/TRAF1/MALT1/PRKCB/TRAF5/CFLAR/BCL2A1/ATM/TNFRSF11A/BIRC2/CXCL2/UBE2I/CSNK2B/CD40/ZAP70/NFKB1/RELB/LCK/CARD14/CHUK/IRAK4/PRKCQ/CXCL3/TRAF3/CCL13/LAT/CYLD/IKBKG/TNFSF14/BCL10/MYD88/CXCL8/CD40LG	36
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	56/1378	194/8135	2.034e-05	0.0005685	0.0003738	NFKBIA/HLA-C/STAT1/JAK2/MAPK3/PLCG2/TBK1/HLA-F/FAS/HLA-G/MICB/HLA-A/TCF7/ANGPT2/GSK3B/CDK4/TYK2/HLA-B/HLA-E/CXCL2/CCR5/JAK1/GNG3/LEF1/GNG12/IRF3/NFKB1/ITPR2/MAPK11/CHUK/PIK3CB/MYC/IL6/PIK3R5/PDGFB/CASP9/VEGFA/UBB/GNB2/CXCL3/TRAF3/MAPKAPK2/PPP3CA/HIF1A/PIK3CD/IKBKG/RAF1/CREB1/TCF7L2/CDKN1A/EP300/CXCL8/KRAS/CALML4/NRAS/PIK3CA	56
KEGG	hsa04659	Th17 cell differentiation	36/1378	108/8135	2.262e-05	0.0005685	0.0003738	NFKBIA/STAT1/JAK2/HLA-DRB4/IL21R/IL27RA/MAPK3/SMAD3/IL2RG/RORA/IL4R/TYK2/RXRA/JAK1/ZAP70/NFKB1/CD3E/IFNG/LCK/MAPK11/CHUK/IL2RB/CD3D/IL6/CD247/HLA-DOB/HLA-DQB1/PRKCQ/PPP3CA/LAT/HIF1A/IKBKG/IL6R/STAT5A/CD3G/IL22	36
KEGG	hsa05020	Prion disease	73/1378	273/8135	2.308e-05	0.0005685	0.0003738	NOTCH1/C7/CCL5/COX7A1/NDUFC1/MAPK3/SLC25A4/SDHC/NDUFA13/NDUFS4/NDUFA4L2/TUBB2B/BAD/NDUFB4/PRNP/NDUFA4/UQCR10/NDUFA8/GSK3B/CREB3/CSNK2B/PSMC2/CYC1/COX6C/COX8A/NDUFA2/COX6A1/NDUFB6/ITPR2/TUBA4A/APAF1/NDUFB7/PSMB6/KIF5C/SDHD/MAPK11/PIK3CB/TUBB6/RAC2/PSMC3/NDUFB2/HSPA6/IL6/EGR1/NDUFA6/COX5B/CASP9/NDUFA10/PSMD8/NDUFB11/PSMB5/PPP3CA/SOD1/NDUFB8/NDUFA3/UQCRQ/PIK3CD/CACNA1D/NDUFS3/CREB1/VDAC3/TUBB2A/NDUFS7/ATF2/NDUFS6/HSPA2/ATF4/NDUFA1/UQCRC1/HSPA5/DDIT3/PIK3CA/NCF1	73
KEGG	hsa05014	Amyotrophic lateral sclerosis	92/1378	364/8135	2.404e-05	0.0005685	0.0003738	SETX/TNFRSF1B/MAP3K5/COX7A1/NDUFC1/DNAL4/TBK1/HNRNPA2B1/SIGMAR1/SDHC/NDUFA13/NDUFS4/NXF3/NDUFA4L2/NUP160/SPG11/TUBB2B/BAD/NUP153/NDUFB4/PFN2/PINK1/DCTN6/NDUFA4/UQCR10/NDUFA8/DCTN3/GPX3/TPR/NUP50/PSMC2/GPX1/CYC1/COX6C/SEC13/GRIA2/COX8A/RANBP2/NDUFA2/NXF1/CAT/COX6A1/NDUFB6/ATG2B/DCTN2/TUBA4A/APAF1/NDUFB7/PSMB6/DAXX/KIF5C/SDHD/MAPK11/ATF6/TUBB6/PSMC3/NDUFB2/ANG/NDUFA6/NUP210/COX5B/CASP9/NDUFA10/HNRNPA1/PSMD8/UBQLN4/NDUFB11/ATG13/PSMB5/OPTN/PPP3CA/SOD1/NUP43/NDC1/NDUFB8/NDUFA3/TARDBP/ANXA7/UQCRQ/NDUFS3/TUBB2A/NDUFS7/NDUFS6/ERBB4/XBP1/ATF4/NDUFA1/UQCRC1/HSPA5/NUP98/DDIT3/NUP62	92
KEGG	hsa05010	Alzheimer disease	96/1378	384/8135	2.561e-05	0.0005685	0.0003738	WNT5B/MAP3K5/COX7A1/NDUFC1/MAPK3/ATP2A3/SNCA/SLC25A4/FAS/SDHC/NDUFA13/NDUFS4/NDUFA4L2/ADAM17/TUBB2B/BAD/HSD17B10/NDUFB4/NDUFA4/UQCR10/APOE/NDUFA8/GSK3B/INSR/IDE/WNT11/CSNK2B/PSMC2/CYC1/FZD3/COX6C/COX8A/NDUFA2/COX6A1/NDUFB6/NFKB1/ATG2B/ITPR2/TUBA4A/APAF1/NDUFB7/PSMB6/KIF5C/SDHD/SLC39A8/CHUK/ATF6/LRP5/PIK3CB/TUBB6/PSMC3/NDUFB2/PSENEN/IL6/NDUFA6/CSNK1A1/COX5B/DKK4/CASP9/NDUFA10/PSMD8/NDUFB11/ATG13/PSMB5/FRAT1/CSNK1E/PPP3CA/SLC39A14/LPL/RTN3/NDUFB8/NDUFA3/UQCRQ/PIK3CD/CACNA1D/APH1B/IKBKG/RAF1/NDUFS3/VDAC3/TUBB2A/NDUFS7/FZD6/NDUFS6/XBP1/KRAS/FZD7/ATF4/NDUFA1/UQCRC1/APH1A/DDIT3/CALML4/FZD2/NRAS/PIK3CA	96
KEGG	hsa04151	PI3K-Akt signaling pathway	89/1378	354/8135	4.039e-05	0.0007986	0.0005251	JAK2/LAMC3/MAPK3/PGF/THBS4/ANGPT1/IL2RG/IL7R/IL4R/SOS1/HGF/DDIT4/G6PC3/BAD/EGFR/EGF/ITGA5/ANGPT2/NTRK2/GSK3B/INSR/CDK4/NTF3/KIT/CREB3/RXRA/FGF20/ERBB2/EFNA5/JAK1/MAGI2/GNG3/GNG12/CHAD/ITGB7/LAMA5/F2R/NFKB1/NTRK1/YWHAH/CHUK/PIK3CB/IGF1/COMP/NOS3/FGF18/KDR/MYC/IL2RB/IL6/PIK3R5/EREG/PDGFB/PCK2/CD19/CASP9/VEGFA/GNB2/MLST8/MCL1/COL6A3/IL3RA/PRKAA1/LPAR2/PIK3CD/NGFR/IKBKG/RAF1/IL6R/THBS2/ITGB5/CREB1/CCND2/GHR/COL4A1/CDKN1A/ATF2/ERBB4/PHLPP1/KRAS/FGF5/COL4A2/ATF4/BDNF/RBL2/VEGFB/EPOR/NRAS/PIK3CA	89
KEGG	hsa04146	Peroxisome	29/1378	82/8135	4.077e-05	0.0007986	0.0005251	ECI2/PEX10/PMVK/EPHX2/ACOX2/PEX19/DECR2/DDO/PHYH/ACSL5/HMGCL/PXMP2/ECH1/PEX7/PEX11A/CAT/PEX2/SCP2/PEX12/PEX14/SOD1/ACOX1/AGPS/ACOT8/MPV17/FAR2/CRAT/PXMP4/MVK	29
KEGG	hsa05221	Acute myeloid leukemia	25/1378	67/8135	4.941e-05	0.0009141	0.000601	CEBPA/MAPK3/DUSP6/CCNA2/BCL2A1/SOS1/TCF7/BAD/PIM1/KIT/LEF1/PIM2/NFKB1/CHUK/PIK3CB/MYC/PML/PIK3CD/IKBKG/RAF1/STAT5A/TCF7L2/KRAS/NRAS/PIK3CA	25
KEGG	hsa05340	Primary immunodeficiency	17/1378	38/8135	5.645e-05	0.0009894	0.0006505	TAP1/DCLRE1C/RFX5/IL2RG/IL7R/PTPRC/CD8A/ADA/CD40/ZAP70/CD3E/LCK/CD3D/CD19/TAP2/IKBKG/CD40LG	17
KEGG	hsa04062	Chemokine signaling pathway	54/1378	192/8135	6.228e-05	0.001037	0.0006818	CXCL9/NFKBIA/CXCL10/STAT1/JAK2/CCL5/MAPK3/PLCG2/CXCL13/CCL18/CXCL11/PRKCB/SOS1/ITK/BAD/CX3CR1/GSK3B/CXCL2/CCR5/GNG3/GNG12/ROCK1/FGR/CXCR4/ARRB1/NFKB1/CCL8/CHUK/PIK3CB/RAC2/PIK3R5/ADCY1/XCL1/GNB2/CCR7/CXCL3/CXCR2/CCL13/PIK3CD/ADCY2/IKBKG/RAF1/GRK6/CCL7/RASGRP2/CXCL8/KRAS/PTK2B/RAP1B/CCR2/NRAS/PIK3CA/CXCR6/NCF1	54
KEGG	hsa04066	HIF-1 signaling pathway	35/1378	109/8135	7.049e-05	0.001118	0.000735	TFRC/MAPK3/PLCG2/ANGPT1/PRKCB/EGFR/EGF/SERPINE1/ANGPT2/INSR/ERBB2/ENO2/PFKFB3/NFKB1/PFKM/IFNG/PIK3CB/IGF1/NOS3/IL6/PDK1/VEGFA/EGLN3/MKNK2/HIF1A/PDHB/PIK3CD/IL6R/ALDOC/TIMP1/CDKN1A/EP300/CUL2/CAMK2B/PIK3CA	35
KEGG	hsa04210	Apoptosis	41/1378	136/8135	8.896e-05	0.001331	0.0008748	NFKBIA/CSF2RB/PARP3/MAP3K5/BIRC3/MAPK3/TRAF1/CTSW/FAS/CFLAR/BCL2A1/ATM/BAD/BIRC2/CTSF/PRF1/GZMB/CTSO/LMNB1/NFKB1/NTRK1/ITPR2/TUBA4A/APAF1/DAXX/CHUK/PIK3CB/CASP9/PARP4/BIRC5/MCL1/IL3RA/DFFB/PIK3CD/IKBKG/RAF1/KRAS/ATF4/DDIT3/NRAS/PIK3CA	41
KEGG	hsa04722	Neurotrophin signaling pathway	37/1378	119/8135	9.521e-05	0.001331	0.0008748	NFKBIA/IRAK3/MAP3K5/MAPK3/RIPK2/PLCG2/SH2B2/SOS1/BAD/NTRK2/GSK3B/NTF3/MAPK7/NFKB1/NTRK1/MAPK11/PIK3CB/IRAK4/SORT1/MAGED1/MAPKAPK2/MAP3K3/MATK/PRDM4/PIK3CD/NGFR/RAF1/SH2B3/KRAS/RPS6KA1/RAP1B/ATF4/CAMK2B/BDNF/CALML4/NRAS/PIK3CA	37
KEGG	hsa04014	Ras signaling pathway	62/1378	232/8135	9.59e-05	0.001331	0.0008748	RASGRP1/MAPK3/RGL1/PLCG2/PGF/TBK1/ANGPT1/PRKCB/PLA2G2D/SOS1/HGF/BAD/REL/EGFR/EGF/ANGPT2/NTRK2/INSR/RASGRP3/RALA/NTF3/KIT/FGF20/EFNA5/GNG3/GNG12/SHOC2/PLD1/ZAP70/NFKB1/NTRK1/PLA2G4C/CHUK/PIK3CB/IGF1/FGF18/EXOC2/KDR/RAC2/RALGDS/PDGFB/VEGFA/PLA1A/PLCE1/GNB2/LAT/PIK3CD/NGFR/IKBKG/RAF1/PAK2/RASAL2/RASGRP2/KRAS/ETS2/RAP1B/FGF5/BDNF/CALML4/VEGFB/NRAS/PIK3CA	62
KEGG	hsa05012	Parkinson disease	69/1378	266/8135	0.0001076	0.001433	0.0009424	MAP3K5/COX7A1/NDUFC1/SLC18A2/SNCA/SLC25A4/SDHC/UCHL1/NDUFA13/NDUFS4/NDUFA4L2/TUBB2B/UBE2J1/NDUFB4/PINK1/NDUFA4/UQCR10/NDUFA8/PSMC2/CYC1/COX6C/COX8A/NDUFA2/COX6A1/NDUFB6/ITPR2/TUBA4A/APAF1/NDUFB7/PSMB6/DAXX/KIF5C/SDHD/SLC39A8/ATF6/TUBB6/SNCAIP/PSMC3/NDUFB2/NDUFA6/TRAP1/COX5B/CASP9/NDUFA10/TXN2/PSMD8/UBB/NDUFB11/PSMB5/SLC39A14/SOD1/NDUFB8/NDUFA3/UQCRQ/UBE2L6/NDUFS3/VDAC3/TUBB2A/NDUFS7/NDUFS6/XBP1/ATF4/NDUFA1/CAMK2B/UQCRC1/HSPA5/TH/DDIT3/CALML4	69
KEGG	hsa04218	Cellular senescence	45/1378	156/8135	0.0001315	0.001685	0.001108	HLA-C/MAPK3/SLC25A4/NBN/SMAD3/HLA-F/CCNA2/HLA-G/HLA-A/ATR/CHEK2/CHEK1/ATM/SERPINE1/CDK4/HLA-B/HLA-E/NFKB1/FOXM1/ITPR2/CCNB2/MAPK11/PIK3CB/CCNB1/MYC/IL6/RAD50/RAD1/MAPKAPK2/PPP3CA/ZFP36L2/PIK3CD/CACNA1D/RAF1/CDK1/VDAC3/RAD9A/CCND2/CDKN1A/CXCL8/KRAS/CALML4/RBL2/NRAS/PIK3CA	45
KEGG	hsa04370	VEGF signaling pathway	22/1378	59/8135	0.0001398	0.001705	0.001121	SPHK1/MAPK3/PLCG2/PRKCB/BAD/SH2D2A/HSPB1/PLA2G4C/MAPK11/PIK3CB/NOS3/KDR/RAC2/CASP9/VEGFA/MAPKAPK2/PPP3CA/PIK3CD/RAF1/KRAS/NRAS/PIK3CA	22
KEGG	hsa05202	Transcriptional misregulation in cancer	53/1378	193/8135	0.0001433	0.001705	0.001121	SIX1/HOXA11/NUPR1/CEBPA/HOXA10/BIRC3/TRAF1/MLF1/DUSP6/CCNA2/BCL2A1/SS18L1/ATM/CDKN2C/REL/BIRC2/BCL11B/RXRA/GZMB/HPGD/PPARG/ITGB7/CD40/ELANE/NFKB1/NTRK1/CCNT2/IGF1/ETV6/MYC/IL2RB/IL6/PML/DEFA6/FUT8/DDB2/ETV7/NCOR1/HDAC1/TSPAN7/NGFR/TCF3/MAF/DEFA5/ID2/CCND2/CDKN1A/CXCL8/CDK9/CEBPB/PBX3/HMGA2/DDIT3	53
KEGG	hsa04068	FoxO signaling pathway	39/1378	131/8135	0.0001758	0.002019	0.001328	MAPK3/GABARAPL1/SMAD3/GABARAPL2/IL7R/SOS1/G6PC3/ATM/EGFR/EGF/INSR/PRKAG1/PRKAB1/CAT/S1PR1/PLK2/CCNB2/MAPK11/CHUK/PIK3CB/IGF1/CCNB1/IL6/PCK2/HOMER3/CSNK1E/NLK/PRKAA1/PIK3CD/RAF1/CCND2/CDKN1A/ATG12/EP300/KRAS/GABARAP/RBL2/NRAS/PIK3CA	39
KEGG	hsa05212	Pancreatic cancer	26/1378	76/8135	0.0001878	0.002085	0.001371	STAT1/MAPK3/SMAD3/BAD/EGFR/EGF/CDK4/RALA/ERBB2/JAK1/PLD1/NFKB1/CHUK/PIK3CB/RAC2/BRCA2/RALGDS/CASP9/VEGFA/DDB2/PIK3CD/IKBKG/RAF1/CDKN1A/KRAS/PIK3CA	26
KEGG	hsa05330	Allograft rejection	16/1378	38/8135	0.0002227	0.002393	0.001573	HLA-C/HLA-DRB4/HLA-F/FAS/HLA-G/HLA-A/HLA-B/HLA-E/PRF1/GZMB/CD28/CD40/IFNG/HLA-DOB/HLA-DQB1/CD40LG	16
KEGG	hsa05163	Human cytomegalovirus infection	59/1378	225/8135	0.0002446	0.002545	0.001673	NFKBIA/TAP1/HLA-C/CCL5/MAPK3/TBK1/HLA-F/FAS/HLA-G/PRKCB/HLA-A/TRAF5/SOS1/EGFR/GSK3B/CDK4/HLA-B/HLA-E/CREB3/CCR5/JAK1/GNG3/GNG12/IRF3/ROCK1/TAPBP/PTGER4/CXCR4/NFKB1/ITPR2/MAPK11/CHUK/PIK3CB/RAC2/MYC/IL6/ADCY1/CASP9/VEGFA/TAP2/GNB2/CXCR2/PPP3CA/PIK3CD/ADCY2/IKBKG/RAF1/IL6R/AKAP13/CREB1/CDKN1A/ATF2/CXCL8/KRAS/PTK2B/ATF4/CALML4/NRAS/PIK3CA	59
KEGG	hsa04668	TNF signaling pathway	34/1378	112/8135	0.0002993	0.002947	0.001938	TNFAIP3/NFKBIA/CXCL10/IRF1/TNFRSF1B/MAP3K5/BIRC3/CCL5/MAPK3/TRAF1/IL15/FAS/TRAF5/CFLAR/BIRC2/CXCL2/CREB3/SELE/MAP3K8/NFKB1/MAPK11/CHUK/PIK3CB/IL6/NOD2/CXCL3/TRAF3/PIK3CD/IKBKG/CREB1/ATF2/CEBPB/ATF4/PIK3CA	34
KEGG	hsa05415	Diabetic cardiomyopathy	54/1378	203/8135	0.0003009	0.002947	0.001938	PDK2/COX7A1/NDUFC1/ATP2A3/SLC25A4/SMAD3/SDHC/PRKCB/NDUFA13/NDUFS4/MPC2/NDUFA4L2/NDUFB4/NDUFA4/UQCR10/NDUFA8/GSK3B/INSR/CMA1/CYC1/COX6C/COX8A/NDUFA2/COX6A1/NDUFB6/NFKB1/NDUFB7/SDHD/AGT/MAPK11/PIK3CB/NOS3/RAC2/NDUFB2/NDUFA6/COX5B/NDUFA10/NDUFB11/PDHB/NDUFB8/NDUFA3/UQCRQ/PIK3CD/NDUFS3/VDAC3/NDUFS7/NDUFS6/COL3A1/MPC1/NDUFA1/CAMK2B/UQCRC1/PIK3CA/NCF1	54
KEGG	hsa04919	Thyroid hormone signaling pathway	36/1378	121/8135	0.0003119	0.002967	0.001951	NOTCH1/DIO3/ATP1B1/STAT1/MAPK3/ATP2A3/PLCG2/PRKCB/MED13/SLC16A2/NCOA3/BAD/NOTCH4/GSK3B/RXRA/BMP4/MED1/MED13L/PFKM/PIK3CB/MYC/CASP9/PLCE1/DIO2/NCOR1/PLCD1/HIF1A/HDAC1/PIK3CD/RAF1/MED27/KAT2B/EP300/KRAS/NRAS/PIK3CA	36
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	109/1378	476/8135	0.0003488	0.003226	0.002121	WNT5B/TNFRSF1B/MAP3K5/COX7A1/NDUFC1/MAPK3/ATP2A3/DNAL4/TBK1/SNCA/SLC25A4/SIGMAR1/FAS/SDHC/PRKCB/UCHL1/NDUFA13/NDUFS4/NDUFA4L2/SPG11/TUBB2B/BAD/HSD17B10/UBE2J1/NDUFB4/PRNP/PINK1/DCTN6/NDUFA4/UQCR10/NDUFA8/GSK3B/DCTN3/GPX3/WNT11/CSNK2B/PSMC2/GPX1/CYC1/FZD3/COX6C/GRIA2/COX8A/NDUFA2/CAT/COX6A1/NDUFB6/NFKB1/ATG2B/DCTN2/ITPR2/TUBA4A/APAF1/NDUFB7/PSMB6/DAXX/KIF5C/SDHD/MAPK11/ATF6/LRP5/TUBB6/SNCAIP/PSMC3/NDUFB2/IL6/NDUFA6/TRAP1/CSNK1A1/COX5B/DKK4/CASP9/NDUFA10/PSMD8/UBB/NDUFB11/ATG13/PSMB5/FRAT1/CSNK1E/OPTN/PPP3CA/SOD1/NDUFB8/NDUFA3/TARDBP/UQCRQ/CACNA1D/RAF1/UBE2L6/NDUFS3/VDAC3/TUBB2A/NDUFS7/FZD6/NDUFS6/XBP1/KRAS/FZD7/ATF4/NDUFA1/CAMK2B/UQCRC1/HSPA5/BDNF/DDIT3/CALML4/FZD2/NRAS	109
KEGG	hsa05132	Salmonella infection	63/1378	249/8135	0.0004415	0.003906	0.002568	NFKBIA/ACTR3B/BIRC3/MAPK3/RIPK2/ARPC1A/SKP1/PTPRC/TCF7/TUBB2B/PFN2/DCTN6/ACTR3/DCTN3/BIRC2/CASP4/RALA/DYNLRB1/STX10/EXOC7/PIK3C2B/LEF1/CYFIP2/NFKB1/DCTN2/VPS16/TUBA4A/KIF5C/MAPK11/CHUK/PIK3CB/EXOC2/TUBB6/DYNC1I1/MYC/IL6/TLR5/IRAK4/DYNC1H1/TXN2/NAIP/ABI1/ARPC5L/PIK3CD/GSDMD/NOD1/IKBKG/RAF1/KPNA1/TCF7L2/RHOH/TUBB2A/CYFIP1/MYD88/KPNA3/FLNA/CXCL8/PIK3C2G/ACTR2/PODXL/ACBD3/PIK3CA/DYNC2LI1	63
KEGG	hsa04142	Lysosome	38/1378	132/8135	0.0004457	0.003906	0.002568	FUCA1/LGMN/GUSB/LAMP3/ATP6V0D1/CTSW/PLA2G15/ENTPD4/CTSA/DMXL2/AP1B1/GNPTAB/AP1G2/CTSF/CTSO/ASAH1/NAGLU/TCIRG1/HEXA/CD63/ABCA2/GM2A/AP4S1/AP1S1/SLC11A1/SORT1/DNASE2/LIPA/NEU1/GAA/MCOLN1/CTSG/CD164/NPC1/SGSH/PSAP/AP4M1/ARSB	38
KEGG	hsa05223	Non-small cell lung cancer	24/1378	72/8135	0.0005075	0.004334	0.002849	MAPK3/PLCG2/PRKCB/SOS1/HGF/BAD/EGFR/EGF/CDK4/RXRA/ERBB2/FHIT/KIF5C/PIK3CB/CASP9/DDB2/PIK3CD/RAF1/STAT5A/CDKN1A/EML4/KRAS/NRAS/PIK3CA	24
KEGG	hsa05164	Influenza A	46/1378	171/8135	0.0006307	0.005251	0.003452	NFKBIA/TPSAB1/CXCL10/TPSB2/STAT1/JAK2/HLA-DRB4/CCL5/MAPK3/ADAR/TBK1/SLC25A4/FAS/PRKCB/NXF3/KPNA2/CDK4/TYK2/JAK1/TPSD1/IRF3/NXF1/NFKB1/IFNG/APAF1/CHUK/PIK3CB/IL6/PML/IRAK4/HLA-DOB/HLA-DQB1/CASP9/TRAF3/DNAJC3/PIK3CD/IKBKG/RAF1/KPNA1/RAB11B/OAS2/EP300/MYD88/CXCL8/NUP98/PIK3CA	46
KEGG	hsa05161	Hepatitis B	44/1378	162/8135	0.0006588	0.00535	0.003518	NFKBIA/STAT1/JAK2/MAPK3/TBK1/SMAD3/FAS/CCNA2/PRKCB/SOS1/BAD/TYK2/CREB3/JAK1/IRF3/NFKB1/STAT4/APAF1/MAPK11/CHUK/PIK3CB/MYC/IL6/IRAK4/CASP9/BIRC5/TRAF3/DDB2/PIK3CD/IKBKG/RAF1/CREB1/VDAC3/STAT5A/CDKN1A/ATF2/EP300/MYD88/CXCL8/KRAS/PTK2B/ATF4/NRAS/PIK3CA	44
KEGG	hsa04662	B cell receptor signaling pathway	26/1378	82/8135	0.0007204	0.005712	0.003755	NFKBIA/MAPK3/PLCG2/DAPP1/MALT1/PRKCB/LILRB2/SOS1/LILRA2/GSK3B/RASGRP3/CD72/CD81/NFKB1/CHUK/PIK3CB/RAC2/CD19/PPP3CA/PIK3CD/IKBKG/RAF1/BCL10/KRAS/NRAS/PIK3CA	26
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	30/1378	100/8135	0.0008239	0.00638	0.004195	STAT1/JAK2/MAPK3/PLCG2/SMAD3/PRKCB/PIM1/SERPINE1/CDK4/SELE/NFKB1/AGT/MAPK11/PIK3CB/NOS3/IL6/EGR1/VEGFA/PLCE1/PLCD1/PIK3CD/STAT5A/COL4A1/COL3A1/CXCL8/KRAS/COL4A2/VEGFB/NRAS/PIK3CA	30
KEGG	hsa05213	Endometrial cancer	20/1378	58/8135	0.0008981	0.006676	0.004389	MAPK3/SOS1/TCF7/BAD/EGFR/EGF/GSK3B/ERBB2/LEF1/PIK3CB/MYC/CASP9/DDB2/PIK3CD/RAF1/TCF7L2/CDKN1A/KRAS/NRAS/PIK3CA	20
KEGG	hsa05144	Malaria	18/1378	50/8135	0.0009021	0.006676	0.004389	THBS4/GYPC/HGF/SDC1/ITGAL/PECAM1/SELE/CD40/CD81/CR1/IFNG/COMP/IL6/HBB/THBS2/MYD88/CXCL8/CD40LG	18
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1378	79/8135	0.0009339	0.006761	0.004445	JAK2/MAPK3/PLCG2/PRKCB/SOS1/HGF/BAD/EGFR/EGF/GSK3B/ERBB2/JAK1/PIK3CB/IGF1/KDR/IL6/AXL/PDGFB/VEGFA/PIK3CD/RAF1/IL6R/KRAS/NRAS/PIK3CA	25
KEGG	hsa04621	NOD-like receptor signaling pathway	48/1378	184/8135	0.001012	0.007172	0.004716	TNFAIP3/GBP1/AIM2/NFKBIA/GBP2/STAT1/BIRC3/CCL5/MAPK3/RIPK2/GABARAPL1/TBK1/TRIP6/GABARAPL2/TRAF5/NLRP1/CARD8/TYK2/BIRC2/CASP4/CXCL2/JAK1/IRF3/NFKB1/ITPR2/MAPK11/CHUK/IL6/IRAK4/NAMPT/DEFA6/TXN2/NOD2/CXCL3/TRAF3/NAIP/IFI16/GSDMD/NOD1/IKBKG/TRPV2/DEFA5/VDAC3/OAS2/ATG12/MYD88/CXCL8/GABARAP	48
KEGG	hsa05215	Prostate cancer	29/1378	97/8135	0.001061	0.007361	0.00484	NFKBIA/AR/MAPK3/SOS1/TCF7/BAD/EGFR/EGF/GSK3B/CREB3/ERBB2/LEF1/NFKB1/CHUK/PIK3CB/IGF1/PDGFB/CASP9/PIK3CD/IKBKG/RAF1/CREB1/TCF7L2/CDKN1A/EP300/KRAS/ATF4/NRAS/PIK3CA	29
KEGG	hsa04940	Type I diabetes mellitus	16/1378	43/8135	0.001143	0.007767	0.005107	HLA-C/HLA-DRB4/HLA-F/FAS/HLA-G/HLA-A/HLA-B/HLA-E/PRF1/GZMB/CD28/IFNG/PTPRN2/HLA-DOB/HLA-DQB1/CPE	16
KEGG	hsa04630	JAK-STAT signaling pathway	43/1378	162/8135	0.001251	0.008225	0.005408	IL11RA/CSF2RB/IL15RA/STAT1/SOCS6/JAK2/IL21R/IL27RA/IL15/IL2RG/IL7R/IL4R/SOS1/EGFR/EGF/PIM1/TYK2/SOCS1/JAK1/CTF1/PTPN2/STAT4/IFNG/PIK3CB/MYC/IL2RB/IL6/PDGFB/MCL1/IL3RA/PIK3CD/RAF1/IL6R/STAT5A/CCND2/GHR/CDKN1A/EP300/IL13RA2/IL22/CISH/EPOR/PIK3CA	43
KEGG	hsa04015	Rap1 signaling pathway	53/1378	210/8135	0.001295	0.008225	0.005408	PRKD2/MAPK3/PGF/ANGPT1/PRKCB/HGF/EGFR/EGF/ITGAL/PFN2/ANGPT2/INSR/RASGRP3/RALA/PRKD3/KIT/FGF20/EFNA5/MAGI2/SIPA1L1/F2R/KRIT1/ARAP3/MAPK11/PRKCI/PIK3CB/IGF1/FGF18/KDR/RAC2/RAPGEF6/ADCY1/RALGDS/SIPA1L3/PDGFB/VEGFA/PLCE1/LAT/LPAR2/TLN2/PIK3CD/NGFR/ADCY2/RAF1/RASGRP2/KRAS/LCP2/RAP1B/FGF5/CALML4/VEGFB/NRAS/PIK3CA	53
KEGG	hsa04012	ErbB signaling pathway	26/1378	85/8135	0.001307	0.008225	0.005408	MAPK3/PLCG2/PRKCB/BTC/SOS1/BAD/EGFR/EGF/NCK2/GSK3B/ERBB2/CBLB/PIK3CB/MYC/HBEGF/EREG/PIK3CD/RAF1/STAT5A/PAK2/CDKN1A/ERBB4/KRAS/CAMK2B/NRAS/PIK3CA	26
KEGG	hsa05162	Measles	38/1378	139/8135	0.001309	0.008225	0.005408	TNFAIP3/NFKBIA/STAT1/ADAR/TBK1/SLAMF1/FAS/IL2RG/BAD/GSK3B/CDK4/TYK2/JAK1/CSNK2B/IRF3/CD28/NFKB1/CBLB/CD3E/APAF1/CHUK/PIK3CB/HSPA6/IL2RB/CD3D/IL6/IRAK4/CASP9/TRAF3/PIK3CD/IKBKG/STAT5A/CCND2/OAS2/MYD88/HSPA2/CD3G/PIK3CA	38
KEGG	hsa05416	Viral myocarditis	20/1378	60/8135	0.00145	0.008944	0.005881	SGCA/HLA-C/HLA-DRB4/SGCG/HLA-F/HLA-G/HLA-A/SGCB/ITGAL/HLA-B/HLA-E/PRF1/CD28/CD40/RAC2/HLA-DOB/HLA-DQB1/CASP9/CXADR/CD40LG	20
KEGG	hsa05222	Small cell lung cancer	27/1378	92/8135	0.002098	0.0127	0.00835	NFKBIA/BIRC3/LAMC3/TRAF1/TRAF5/CKS1B/CDK4/BIRC2/BIRC7/RXRA/FHIT/LAMA5/CKS2/NFKB1/APAF1/CHUK/PIK3CB/MYC/CASP9/TRAF3/DDB2/PIK3CD/IKBKG/COL4A1/CDKN1A/COL4A2/PIK3CA	27
KEGG	hsa05165	Human papillomavirus infection	76/1378	331/8135	0.002474	0.01471	0.009673	NOTCH1/HLA-C/WNT5B/STAT1/IRF1/LAMC3/MAPK3/TUBG2/THBS4/TBK1/ATP6V0D1/HLA-F/FAS/CCNA2/HLA-G/HLA-A/ATR/SOS1/TCF7/ATM/BAD/EGFR/EGF/ITGA5/TADA3/NOTCH4/GSK3B/CDK4/TYK2/HLA-B/HLA-E/CREB3/JAK1/WNT11/RFNG/IRF3/CHAD/FZD3/ITGB7/PTGER4/LAMA5/TCIRG1/MAML1/NFKB1/CHUK/PRKCI/PIK3CB/COMP/RBPJ/CSNK1A1/VEGFA/LLGL2/ATP6V0E2/TRAF3/COL6A3/HDAC1/PIK3CD/IKBKG/RAF1/THBS2/ITGB5/CREB1/TCF7L2/CCND2/COL4A1/CDKN1A/FZD6/EP300/UBR4/KRAS/COL4A2/FZD7/FZD2/RBL2/NRAS/PIK3CA	76
KEGG	hsa05016	Huntington disease	71/1378	306/8135	0.002556	0.01489	0.009789	MAP3K5/COX7A1/NDUFC1/DNAL4/SLC25A4/SDHC/NDUFA13/NDUFS4/POLR2J/NDUFA4L2/POLR2I/POLR2L/TUBB2B/POLR2E/NDUFB4/POLR2F/DCTN6/NDUFA4/UQCR10/NDUFA8/DCTN3/GPX3/AP2M1/CREB3/PSMC2/PPARG/POLR2C/GPX1/CYC1/COX6C/GRIA2/COX8A/NDUFA2/COX6A1/NDUFB6/ATG2B/DCTN2/TUBA4A/APAF1/NDUFB7/PSMB6/KIF5C/SDHD/TUBB6/PSMC3/NDUFB2/POLR2G/NDUFA6/COX5B/CASP9/NDUFA10/PSMD8/NDUFB11/ATG13/PSMB5/SOD1/RCOR1/HDAC1/NDUFB8/NDUFA3/UQCRQ/NDUFS3/CREB1/VDAC3/TUBB2A/NDUFS7/NDUFS6/EP300/NDUFA1/UQCRC1/BDNF	71
KEGG	hsa05332	Graft-versus-host disease	15/1378	42/8135	0.002593	0.01489	0.009789	HLA-C/HLA-DRB4/HLA-F/FAS/HLA-G/HLA-A/HLA-B/HLA-E/PRF1/GZMB/CD28/IFNG/IL6/HLA-DOB/HLA-DQB1	15
KEGG	hsa04110	Cell cycle	34/1378	126/8135	0.002893	0.01633	0.01074	CDC25B/CDC7/SKP1/SMAD3/CCNA2/ATR/CHEK2/CHEK1/ATM/CDKN2C/ORC3/PTTG1/GSK3B/CDK4/DBF4/BUB1B/ORC6/CDC14A/YWHAH/CCNB2/CCNB1/CCNH/MYC/CDKN1C/CDC20/SMC1A/HDAC1/CDK1/CCND2/CDKN1A/WEE1/EP300/PTTG2/RBL2	34
KEGG	hsa05203	Viral carcinogenesis	50/1378	204/8135	0.003358	0.01863	0.01225	NFKBIA/HLA-C/MAPK3/ATP6V0D1/TRAF1/HLA-F/CCNA2/HLA-G/HLA-A/TRAF5/CHEK1/BAD/REL/CDK4/HLA-B/HLA-E/CREB3/CCR5/JAK1/HNRNPK/IRF3/NFKB1/YWHAH/GTF2A2/PIK3CB/RBPJ/CDC20/SCIN/TRAF3/MAPKAPK2/HDAC1/PIK3CD/IKBKG/CREB1/CDK1/VDAC3/STAT5A/CCND2/KAT2B/CDKN1A/ATF2/EP300/ACTN1/UBR4/KRAS/GTF2H3/ATF4/RBL2/NRAS/PIK3CA	50
KEGG	hsa05210	Colorectal cancer	25/1378	86/8135	0.003467	0.01893	0.01244	MAPK3/SMAD3/SOS1/TCF7/BAD/EGFR/EGF/GSK3B/RALA/LEF1/PIK3CB/RAC2/MYC/RALGDS/EREG/CASP9/BIRC5/DDB2/PIK3CD/RAF1/TCF7L2/CDKN1A/KRAS/NRAS/PIK3CA	25
KEGG	hsa01524	Platinum drug resistance	22/1378	73/8135	0.003657	0.01964	0.01291	GSTA4/MAP3K5/BIRC3/MAPK3/ERCC1/FAS/ATM/BAD/BIRC2/MGST3/GSTM4/ERBB2/APAF1/PIK3CB/GSTM5/GSTM3/CASP9/BIRC5/TOP2A/PIK3CD/CDKN1A/PIK3CA	22
KEGG	hsa05224	Breast cancer	38/1378	147/8135	0.003832	0.02026	0.01332	NOTCH1/WNT5B/MAPK3/SOS1/NCOA3/TCF7/EGFR/EGF/NOTCH4/GSK3B/CDK4/KIT/FGF20/ERBB2/WNT11/LEF1/FZD3/LRP5/PIK3CB/IGF1/FGF18/MYC/BRCA2/CSNK1A1/FRAT1/DDB2/JAG2/PIK3CD/RAF1/TCF7L2/CDKN1A/FZD6/KRAS/FGF5/FZD7/FZD2/NRAS/PIK3CA	38
KEGG	hsa00280	Valine, leucine and isoleucine degradation	16/1378	48/8135	0.0042	0.02186	0.01437	IVD/ALDH7A1/ECHS1/BCKDHB/HSD17B10/PCCB/HMGCL/HADH/OXCT1/ACAT1/DLD/ALDH9A1/ALDH3A2/ACADM/ACAA2/ALDH6A1	16
KEGG	hsa00190	Oxidative phosphorylation	35/1378	134/8135	0.004505	0.02308	0.01517	COX7A1/NDUFC1/ATP6V0D1/SDHC/NDUFA13/NDUFS4/NDUFA4L2/NDUFB4/NDUFA4/UQCR10/NDUFA8/CYC1/COX6C/COX8A/NDUFA2/TCIRG1/COX6A1/NDUFB6/NDUFB7/SDHD/NDUFB2/NDUFA6/COX5B/NDUFA10/ATP6V0E2/NDUFB11/NDUFB8/NDUFA3/UQCRQ/NDUFS3/NDUFS7/NDUFS6/NDUFA1/UQCRC1/PPA2	35
KEGG	hsa05225	Hepatocellular carcinoma	42/1378	168/8135	0.004708	0.02352	0.01547	GSTA4/WNT5B/MAPK3/PLCG2/SMAD3/PRKCB/SOS1/HGF/TCF7/BAD/EGFR/SMARCD3/NQO1/GSK3B/CDK4/MGST3/GSTM4/WNT11/LEF1/FZD3/ARID1A/LRP5/PIK3CB/MYC/GSTM5/CSNK1A1/GSTM3/PBRM1/FRAT1/DDB2/SMARCD2/PIK3CD/RAF1/TCF7L2/CDKN1A/FZD6/TXNRD2/KRAS/FZD7/FZD2/NRAS/PIK3CA	42
KEGG	hsa04917	Prolactin signaling pathway	21/1378	70/8135	0.004732	0.02352	0.01547	STAT1/IRF1/SOCS6/JAK2/MAPK3/SOS1/TNFRSF11A/GSK3B/SOCS1/NFKB1/MAPK11/PIK3CB/PIK3CD/RAF1/STAT5A/CCND2/KRAS/CISH/TH/NRAS/PIK3CA	21
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/1378	11/8135	0.004981	0.02439	0.01604	VKORC1/HPD/NQO1/COQ6/GGCX/COQ2	6
KEGG	hsa05145	Toxoplasmosis	30/1378	112/8135	0.005557	0.02666	0.01753	NFKBIA/STAT1/BIRC3/JAK2/HLA-DRB4/LAMC3/MAPK3/BAD/TYK2/BIRC2/BIRC7/SOCS1/CCR5/JAK1/CD40/LAMA5/NFKB1/IFNG/MAPK11/CHUK/HSPA6/PIK3R5/IRAK4/HLA-DOB/HLA-DQB1/CASP9/IKBKG/MYD88/HSPA2/CD40LG	30
KEGG	hsa05219	Bladder cancer	14/1378	41/8135	0.005666	0.02666	0.01753	MAPK3/EGFR/EGF/CDK4/ERBB2/TYMP/MYC/HBEGF/VEGFA/RAF1/CDKN1A/CXCL8/KRAS/NRAS	14
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	13/1378	37/8135	0.005764	0.02666	0.01753	ATP1B1/MAPK3/PRKCB/HSD11B2/INSR/PIK3CB/IGF1/NR3C2/PIK3CD/SLC9A3R2/KRAS/NEDD4L/PIK3CA	13
KEGG	hsa05216	Thyroid cancer	13/1378	37/8135	0.005764	0.02666	0.01753	MAPK3/TCF7/TPR/RXRA/LEF1/PPARG/NTRK1/MYC/DDB2/TCF7L2/CDKN1A/KRAS/NRAS	13
KEGG	hsa05135	Yersinia infection	35/1378	137/8135	0.006554	0.0299	0.01966	NFKBIA/ACTR3B/MAPK3/ARPC1A/GIT2/TBK1/CD8A/ITGA5/BAIAP2/ACTR3/GSK3B/IRF3/ROCK1/ZAP70/NFKB1/LCK/ARHGEF7/WIPF1/MAPK11/CHUK/PIK3CB/RAC2/IL6/IRAK4/LAT/ARPC5L/PIK3CD/IKBKG/MYD88/CXCL8/RPS6KA1/LCP2/PTK2B/ACTR2/PIK3CA	35
KEGG	hsa00790	Folate biosynthesis	10/1378	26/8135	0.007293	0.0328	0.02157	GCH1/AKR1B1/AKR1B10/QDPR/PCBD1/MOCS2/GGH/AKR1C3/CBR1/TH	10
KEGG	hsa04714	Thermogenesis	54/1378	232/8135	0.007388	0.0328	0.02157	MAP3K5/COX7A1/NDUFC1/NDUFAF3/SDHC/NDUFA13/NDUFS4/NDUFA4L2/SOS1/NDUFB4/SMARCD3/NDUFA4/UQCR10/NDUFA8/ACSL5/CREB3/PRKAG1/PRKAB1/PPARG/CYC1/KDM3A/COX6C/COX8A/NDUFA2/ARID1A/COX6A1/NDUFB6/NDUFB7/SDHD/MAPK11/NDUFB2/ADCY1/NDUFA6/COX5B/NDUFA10/COA3/NDUFB11/MLST8/SMARCD2/NDUFB8/PRKAA1/NDUFA3/UQCRQ/ADCY2/NDUFS3/CREB1/NDUFS7/ATF2/NDUFS6/KRAS/RPS6KA1/NDUFA1/UQCRC1/NRAS	54
KEGG	hsa05211	Renal cell carcinoma	20/1378	69/8135	0.008722	0.03822	0.02513	MAPK3/SOS1/HGF/BAD/PIK3CB/PDGFB/VEGFA/EGLN3/HIF1A/PIK3CD/RAF1/PAK2/CDKN1A/EP300/CUL2/KRAS/RAP1B/FH/NRAS/PIK3CA	20
KEGG	hsa01522	Endocrine resistance	26/1378	98/8135	0.01072	0.04634	0.03047	NOTCH1/MAPK3/SOS1/NCOA3/CDKN2C/BAD/EGFR/NOTCH4/CDK4/ERBB2/MED1/GPER1/MAPK11/PIK3CB/IGF1/HBEGF/ADCY1/NCOR1/JAG2/PIK3CD/ADCY2/RAF1/CDKN1A/KRAS/NRAS/PIK3CA	26
KEGG	hsa04657	IL-17 signaling pathway	25/1378	94/8135	0.0118	0.05039	0.03313	TNFAIP3/NFKBIA/CXCL10/MAPK3/TBK1/TRAF5/GSK3B/CXCL2/MAPK7/NFKB1/IFNG/MAPK11/CHUK/IL6/MMP13/IL17RB/CXCL3/TRAF3/IL17RC/MUC5AC/IKBKG/CCL7/CXCL8/CEBPB/IL17RA	25
KEGG	hsa05320	Autoimmune thyroid disease	16/1378	53/8135	0.01201	0.05039	0.03313	HLA-C/HLA-DRB4/HLA-F/FAS/HLA-G/HLA-A/CTLA4/HLA-B/HLA-E/PRF1/GZMB/CD28/CD40/HLA-DOB/HLA-DQB1/CD40LG	16
KEGG	hsa04213	Longevity regulating pathway - multiple species	18/1378	62/8135	0.01225	0.05039	0.03313	INSR/PRKAG1/PRKAB1/CRYAB/CAT/PIK3CB/IGF1/HSPA6/ADCY1/SOD1/HDAC1/PRKAA1/PIK3CD/ADCY2/HSPA2/KRAS/NRAS/PIK3CA	18
KEGG	hsa04640	Hematopoietic cell lineage	26/1378	99/8135	0.01226	0.05039	0.03313	IL11RA/HLA-DRB4/TFRC/IL7R/IL4R/CD38/CD8A/ITGA5/KIT/CD44/CD3E/CR1/CD3D/IL6/CD7/HLA-DOB/CD19/HLA-DQB1/IL3RA/CD2/IL6R/CD3G/MS4A1/ANPEP/EPOR/CD59	26
KEGG	hsa01232	Nucleotide metabolism	23/1378	85/8135	0.01243	0.05048	0.03319	HDDC2/NME4/TK2/ENPP1/NME7/ENTPD4/IMPDH2/NT5C2/ADK/ADA/RRM2/DGUOK/NME3/TYMP/AK1/PNP/AK6/GUK1/DCTD/CTPS1/TYMS/NT5E/AMPD3	23
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1378	100/8135	0.01397	0.05606	0.03686	CXCL9/CXCL10/TNFRSF1B/CCL5/CXCL13/CCL18/IL2RG/CXCL11/CX3CR1/TNFRSF14/CXCL2/CCR5/CXCR4/CCL8/IL2RB/IL6/XCL1/CCR7/CXCL3/CXCR2/CCL13/IL6R/TNFSF14/CCL7/CXCL8/CCR2	26
KEGG	hsa03440	Homologous recombination	13/1378	41/8135	0.01478	0.05858	0.03852	TOPBP1/NBN/POLD2/ATM/BARD1/RPA1/RPA3/POLD4/BRCA2/RAD51C/RAD50/BABAM1/RAD51B	13
KEGG	hsa00120	Primary bile acid biosynthesis	7/1378	17/8135	0.01591	0.06234	0.04099	CH25H/ACOX2/SLC27A5/CYP7B1/SCP2/ACOT8/AKR1C4	7
KEGG	hsa04115	p53 signaling pathway	20/1378	73/8135	0.01654	0.06406	0.04212	FAS/ATR/CHEK2/CHEK1/ATM/SIVA1/SERPINE1/CDK4/RRM2/APAF1/CCNB2/IGF1/CCNB1/CASP9/DDB2/GTSE1/CDK1/CCND2/CDKN1A/SESN1	20
KEGG	hsa04612	Antigen processing and presentation	21/1378	78/8135	0.0174	0.06658	0.04378	TAP1/HLA-C/LGMN/HLA-DRB4/RFX5/HLA-F/HLA-G/HLA-A/CD8A/HLA-B/HLA-E/TAPBP/IFNG/HSPA6/HLA-DOB/HLA-DQB1/TAP2/CREB1/HSPA2/NFYC/HSPA5	21
KEGG	hsa04145	Phagosome	36/1378	152/8135	0.01968	0.07448	0.04897	TAP1/HLA-C/HLA-DRB4/TFRC/COLEC12/THBS4/ATP6V0D1/HLA-F/HLA-G/HLA-A/MRC2/OLR1/TUBB2B/PIKFYVE/ITGA5/HLA-B/HLA-E/SEC22B/TCIRG1/VAMP3/TUBA4A/COMP/TUBB6/DYNC1I1/HLA-DOB/HLA-DQB1/DYNC1H1/PLA2R1/TAP2/ATP6V0E2/SEC61A2/MBL2/THBS2/ITGB5/TUBB2A/NCF1	36
KEGG	hsa00620	Pyruvate metabolism	14/1378	47/8135	0.02043	0.07609	0.05003	ALDH7A1/ME2/PC/MDH2/ACAT1/DLD/ALDH9A1/GRHPR/PCK2/ALDH3A2/PDHB/GLO1/MDH1/FH	14
KEGG	hsa04931	Insulin resistance	27/1378	108/8135	0.02065	0.07609	0.05003	NFKBIA/PPP1R3C/PRKCB/PTPRF/G6PC3/SLC27A6/GSK3B/INSR/SLC27A5/CREB3/PRKAG1/PRKAB1/PYGM/NFKB1/AGT/PIK3CB/NOS3/NR1H2/IL6/PCK2/PRKCQ/OGT/PRKAA1/PIK3CD/CREB1/RPS6KA1/PIK3CA	27
KEGG	hsa05230	Central carbon metabolism in cancer	19/1378	70/8135	0.02113	0.07609	0.05003	MAPK3/SLC7A5/EGFR/SCO2/KIT/ERBB2/NTRK1/PFKM/SIRT3/PIK3CB/MYC/PDK1/HIF1A/PDHB/PIK3CD/RAF1/KRAS/NRAS/PIK3CA	19
KEGG	hsa04380	Osteoclast differentiation	31/1378	128/8135	0.02152	0.07609	0.05003	NFKBIA/TREM2/STAT1/TNFRSF11B/MAPK3/PLCG2/LILRB2/LILRA2/TNFRSF11A/TYK2/SOCS1/JAK1/PPARG/NFKB1/RELB/IFNG/LCK/MAPK11/CHUK/PIK3CB/TYROBP/CALCR/PPP3CA/CYLD/PIK3CD/IKBKG/CREB1/FHL2/LCP2/PIK3CA/NCF1	31
KEGG	hsa00020	Citrate cycle (TCA cycle)	10/1378	30/8135	0.0217	0.07609	0.05003	SDHC/PC/MDH2/SDHD/DLD/PCK2/PDHB/SUCLG1/MDH1/FH	10
KEGG	hsa01523	Antifolate resistance	10/1378	30/8135	0.0217	0.07609	0.05003	FOLR1/ABCC4/GGH/NFKB1/FOLR2/ABCC1/CHUK/IL6/IKBKG/TYMS	10
KEGG	hsa04072	Phospholipase D signaling pathway	35/1378	148/8135	0.02171	0.07609	0.05003	SPHK1/MS4A2/MAPK3/PLCG2/AGPAT1/FCER1A/SOS1/EGFR/EGF/AGPAT5/DGKA/INSR/RALA/KIT/PLD1/PTGFR/F2R/PLA2G4C/DGKZ/AGT/PIK3CB/PIK3R5/ADCY1/RALGDS/PDGFB/CXCR2/LPAR2/PIK3CD/ADCY2/RAF1/CXCL8/KRAS/PTK2B/NRAS/PIK3CA	35
KEGG	hsa05214	Glioma	20/1378	75/8135	0.02211	0.07669	0.05043	MAPK3/PLCG2/PRKCB/SOS1/EGFR/EGF/CDK4/PIK3CB/IGF1/PDGFB/DDB2/CAMK1/PIK3CD/RAF1/CDKN1A/KRAS/CAMK2B/CALML4/NRAS/PIK3CA	20
KEGG	hsa04620	Toll-like receptor signaling pathway	26/1378	104/8135	0.02284	0.0784	0.05155	CXCL9/NFKBIA/CXCL10/STAT1/CCL5/MAPK3/TBK1/CXCL11/IRF3/TOLLIP/CD40/MAP3K8/NFKB1/MAPK11/CHUK/PIK3CB/IL6/TLR5/IRAK4/TRAF3/PIK3CD/IKBKG/MYD88/CXCL8/TLR8/PIK3CA	26
KEGG	hsa05417	Lipid and atherosclerosis	48/1378	215/8135	0.02334	0.0793	0.05214	NFKBIA/MAP3K5/JAK2/CCL5/MAPK3/TBK1/FAS/OLR1/BAD/GSK3B/CXCL2/RXRA/SELE/IRF3/PPARG/CD40/POU2F1/NFKB1/APAF1/MAPK11/CHUK/ATF6/PIK3CB/NOS3/HSPA6/IL6/IRAK4/CASP9/CXCL3/TRAF3/PPP3CA/PIK3CD/IKBKG/XBP1/MYD88/HSPA2/CXCL8/KRAS/RAP1B/CD40LG/ATF4/CAMK2B/HSPA5/DDIT3/CALML4/NRAS/PIK3CA/NCF1	48
KEGG	hsa04935	Growth hormone synthesis, secretion and action	29/1378	119/8135	0.02362	0.07946	0.05224	STAT1/JAK2/MAPK3/PLCG2/PRKCB/SOS1/GSK3B/SOCS1/CREB3/ITPR2/MAPK11/PIK3CB/IGF1/GHSR/ADCY1/SSTR5/PIK3CD/CACNA1D/ADCY2/RAF1/CREB1/STAT5A/GHR/ATF2/EP300/KRAS/ATF4/NRAS/PIK3CA	29
KEGG	hsa05134	Legionellosis	16/1378	57/8135	0.02415	0.08044	0.05289	NFKBIA/CXCL2/SEC22B/NFKB1/CR1/APAF1/HSPA6/IL6/TLR5/CASP9/CXCL3/NAIP/MYD88/HSPA2/CLK1/CXCL8	16
KEGG	hsa05220	Chronic myeloid leukemia	20/1378	76/8135	0.02538	0.08369	0.05502	NFKBIA/MAPK3/SMAD3/SOS1/BAD/CDK4/NFKB1/CHUK/PIK3CB/MYC/DDB2/HDAC1/PIK3CD/IKBKG/RAF1/STAT5A/CDKN1A/KRAS/NRAS/PIK3CA	20
KEGG	hsa01200	Carbon metabolism	28/1378	115/8135	0.02612	0.08481	0.05576	SDS/ECHS1/SDHC/GOT1/ME2/PCCB/ENO2/PC/ESD/CAT/PFKM/MDH2/SDHD/ACAT1/DLD/PSPH/CPS1/PDHB/ACOX1/SUCLG1/ALDOC/ALDH6A1/MDH1/PRPS1/PRPS2/FH/RPE/ADPGK	28
KEGG	hsa04060	Cytokine-cytokine receptor interaction	63/1378	295/8135	0.02623	0.08481	0.05576	CXCL9/IL11RA/CSF2RB/IL15RA/CXCL10/TNFRSF1B/TNFRSF11B/CCL5/IL32/IL21R/IL27RA/CXCL13/CCL18/IL15/FAS/IL2RG/CXCL11/IL7R/IL4R/TNFRSF21/CX3CR1/TNFRSF11A/TNFRSF14/CXCL2/CCR5/BMP4/GDF5/TNFRSF17/CTF1/IL1RL2/CD40/CXCR4/CCL8/CD27/IFNG/IL2RB/IL6/XCL1/IL17RB/TNFSF4/CCR7/CXCL3/CXCR2/CCL13/IL3RA/TNFSF8/IL17RC/IL1RN/GDF9/NGFR/IL6R/TNFSF14/GHR/CCL7/INHBB/CXCL8/IL13RA2/CCR2/CD40LG/IL22/IL17RA/EPOR/CXCR6	63
KEGG	hsa05218	Melanoma	19/1378	72/8135	0.02807	0.08969	0.05897	MAPK3/HGF/BAD/EGFR/EGF/CDK4/FGF20/PIK3CB/IGF1/FGF18/PDGFB/DDB2/PIK3CD/RAF1/CDKN1A/KRAS/FGF5/NRAS/PIK3CA	19
KEGG	hsa00480	Glutathione metabolism	16/1378	58/8135	0.02828	0.08969	0.05897	HPGDS/GSTA4/LAP3/GPX3/PRDX6/RRM2/SMS/MGST3/GSTM4/GPX1/GPX4/GSTM5/GSTM3/SRM/GGCT/ANPEP	16
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	31/1378	131/8135	0.0292	0.09174	0.06032	HLA-C/MAPK3/PLCG2/FAS/HLA-G/PRKCB/MICB/HLA-A/SOS1/ITGAL/HLA-B/HLA-E/PRF1/GZMB/ZAP70/IFNG/LCK/PIK3CB/RAC2/CD247/TYROBP/ULBP2/PPP3CA/LAT/PIK3CD/RAF1/KRAS/LCP2/PTK2B/NRAS/PIK3CA	31
KEGG	hsa04614	Renin-angiotensin system	8/1378	23/8135	0.02991	0.0931	0.06121	CPA3/CTSA/CMA1/AGT/LNPEP/CTSG/ANPEP/PREP	8
KEGG	hsa05160	Hepatitis C	36/1378	157/8135	0.0313	0.09594	0.06308	NFKBIA/CXCL10/STAT1/MAPK3/TBK1/FAS/CFLAR/SOS1/BAD/EGFR/EGF/GSK3B/CDK4/TYK2/RXRA/JAK1/IRF3/CLDN11/CD81/NFKB1/YWHAH/IFNG/APAF1/CHUK/PIK3CB/MYC/CASP9/TRAF3/PIK3CD/IKBKG/RAF1/CDKN1A/OAS2/KRAS/NRAS/PIK3CA	36
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	24/1378	97/8135	0.0314	0.09594	0.06308	SPHK1/ACTR3B/MAPK3/ARPC1A/PLCG2/LIMK2/PRKCB/PTPRC/ASAP1/MARCKSL1/ACTR3/BIN1/PLD1/PLA2G4C/PIK3CB/RAC2/SCIN/LAT/ARPC5L/PIK3CD/RAF1/ACTR2/PIK3CA/NCF1	24
KEGG	hsa04723	Retrograde endocannabinoid signaling	34/1378	148/8135	0.03475	0.1052	0.06916	NDUFC1/MAPK3/PRKCB/ABHD6/NDUFA13/NDUFS4/NDUFA4L2/GABRB1/NDUFB4/NDUFA4/NDUFA8/GNG3/GABRA4/GNG12/GRIA2/NDUFA2/NDUFB6/ITPR2/NDUFB7/MAPK11/NDUFB2/ADCY1/NDUFA6/NDUFA10/NDUFB11/GNB2/NDUFB8/NDUFA3/CACNA1D/ADCY2/NDUFS3/NDUFS7/NDUFS6/NDUFA1	34
KEGG	hsa05205	Proteoglycans in cancer	45/1378	205/8135	0.03574	0.107	0.07035	WNT5B/MAPK3/PLCG2/FAS/PRKCB/SOS1/HGF/SDC1/EGFR/ITGA5/ERBB2/WNT11/ROCK1/FZD3/ANK3/CD44/PPP1R12A/ITPR2/CD63/MAPK11/PIK3CB/IGF1/KDR/MYC/HBEGF/HSPB2/VEGFA/PLCE1/HIF1A/CTTN/PIK3CD/RAF1/ITGB5/CDKN1A/FZD6/ERBB4/FLNA/KRAS/FZD7/SMO/CAMK2B/TWIST1/FZD2/NRAS/PIK3CA	45
KEGG	hsa05131	Shigellosis	53/1378	247/8135	0.03599	0.107	0.07035	NFKBIA/ACTR3B/FNBP1/CCL5/UBE2D4/MAPK3/RIPK2/ARPC1A/PLCG2/SKP1/TBK1/MALT1/TNIP1/TRAF5/ATM/EGFR/ITGA5/PFN2/ACTR3/GSK3B/CASP4/CAPNS1/RRAGA/ARHGEF2/IRF3/ROCK1/CD44/NFKB1/ITPR2/MAPK11/CHUK/PIK3CB/TLR5/UBB/PLCE1/GLMN/PRKCQ/NAIP/PLCD1/ARPC5L/TLN2/CTTN/PIK3CD/NOD1/IKBKG/RRAGD/BCL10/ATG12/MYD88/ACTN1/CXCL8/ACTR2/PIK3CA	53
KEGG	hsa05226	Gastric cancer	34/1378	149/8135	0.03795	0.1118	0.07353	WNT5B/MAPK3/SMAD3/SOS1/HGF/TCF7/EGFR/EGF/GSK3B/RXRA/FGF20/ERBB2/WNT11/LEF1/FZD3/LRP5/PIK3CB/FGF18/MYC/CSNK1A1/FRAT1/DDB2/ABCB1/PIK3CD/RAF1/TCF7L2/CDKN1A/FZD6/KRAS/FGF5/FZD7/FZD2/NRAS/PIK3CA	34
KEGG	hsa05418	Fluid shear stress and atherosclerosis	32/1378	139/8135	0.03858	0.1123	0.07385	GSTA4/MAP3K5/SDC1/NQO1/PECAM1/MAPK7/MGST3/BMP4/GSTM4/ARHGEF2/SELE/NFKB1/CDH5/IFNG/ASS1/MAPK11/CHUK/PIK3CB/NOS3/KDR/RAC2/GSTM5/PDGFB/GSTM3/VEGFA/TXN2/PRKAA1/PIK3CD/IKBKG/CALML4/PIK3CA/NCF1	32
KEGG	hsa04510	Focal adhesion	44/1378	201/8135	0.03911	0.1123	0.07385	BIRC3/LAMC3/MAPK3/PGF/THBS4/PRKCB/SOS1/HGF/BAD/EGFR/EGF/ITGA5/GSK3B/BIRC2/ERBB2/ROCK1/CHAD/ITGB7/LAMA5/PPP1R12A/PIK3CB/IGF1/COMP/KDR/RAC2/PDGFB/VEGFA/ARHGAP35/COL6A3/PARVB/TLN2/PIK3CD/RAF1/THBS2/ITGB5/PAK2/CCND2/COL4A1/ACTN1/FLNA/RAP1B/COL4A2/VEGFB/PIK3CA	44
KEGG	hsa04625	C-type lectin receptor signaling pathway	25/1378	104/8135	0.03937	0.1123	0.07385	NFKBIA/STAT1/IRF1/MAPK3/PLCG2/MALT1/NFKB1/CBLB/RELB/ITPR2/MAPK11/CHUK/PIK3CB/IL6/MAPKAPK2/PPP3CA/CYLD/PIK3CD/IKBKG/RAF1/BCL10/KRAS/CALML4/NRAS/PIK3CA	25
KEGG	hsa05321	Inflammatory bowel disease	17/1378	65/8135	0.03946	0.1123	0.07385	STAT1/HLA-DRB4/IL21R/SMAD3/IL2RG/RORA/IL4R/NFKB1/STAT4/IFNG/IL6/TLR5/HLA-DOB/HLA-DQB1/NOD2/MAF/IL22	17
KEGG	hsa00330	Arginine and proline metabolism	14/1378	51/8135	0.0402	0.113	0.07427	ALDH7A1/GAMT/GOT1/LAP3/AGMAT/SMS/GATM/NOS3/ALDH9A1/ALDH3A2/OAT/SRM/PYCR1/ALDH18A1	14
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/1378	70/8135	0.0406	0.113	0.07427	NFKBIA/CCL5/PLCG2/ATP6V0D1/ADAM17/EGFR/CXCL2/TCIRG1/NFKB1/MAPK11/CHUK/HBEGF/ATP6V0E2/CXCL3/CXCR2/NOD1/IKBKG/CXCL8	18
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	46/1378	212/8135	0.04071	0.113	0.07427	GSTA4/EPHX1/AR/JAK2/MAPK3/EPHX2/PRKCB/SOS1/BAD/EGFR/EGF/KPNA2/CREB3/MGST3/RXRA/FGF20/GSTM4/ARRB1/ADRB2/NFKB1/CHRNA3/PIK3CB/FGF18/UGT2B17/MYC/GSTM5/ADCY1/GSTM3/VEGFA/BIRC5/KPNB1/PIK3CD/CACNA1D/ADCY2/RAF1/CREB1/KPNA1/STAT5A/ATF2/KPNA3/KRAS/RPS6KA1/FGF5/ATF4/NRAS/PIK3CA	46
KEGG	hsa04810	Regulation of actin cytoskeleton	47/1378	218/8135	0.04294	0.1182	0.07769	IQGAP2/ACTR3B/MAPK3/ARPC1A/LIMK2/SOS1/ITGAX/EGFR/EGF/ITGAL/PIKFYVE/ITGA5/ITGAE/PFN2/BAIAP2/ACTR3/FGF20/GNG12/CYFIP2/ROCK1/ITGB7/CXCR4/SSH3/F2R/PPP1R12A/DIAPH2/ARHGEF7/PIK3CB/FGF18/RAC2/PDGFB/SCIN/ARHGAP35/ARPC5L/LPAR2/PIK3CD/RAF1/ITGB5/PAK2/CYFIP1/ACTN1/KRAS/FGF5/ACTR2/MYH10/NRAS/PIK3CA	47
KEGG	hsa04020	Calcium signaling pathway	51/1378	240/8135	0.04563	0.1246	0.0819	SPHK1/TACR2/ATP2A3/PLCG2/SLC25A4/PRKCB/CD38/HGF/PDE1A/EGFR/EGF/NTRK2/FGF20/ERBB2/HTR2B/ASPH/CXCR4/PTGFR/F2R/ADRB2/NTRK1/ITPR2/MCOLN3/ATP2B2/NOS3/FGF18/KDR/ADCY1/PDGFB/VEGFA/P2RX4/PLCE1/PPP3CA/CAMK1/PLCD1/ORAI3/TPCN1/MCOLN1/ATP2B4/CACNA1D/ADCY2/VDAC3/CCKAR/GNA14/ERBB4/PTK2B/FGF5/CAMK2B/ATP2B1/CALML4/VEGFB	51
KEGG	hsa04144	Endocytosis	53/1378	251/8135	0.04681	0.1267	0.08333	FOLR1/HLA-C/ACTR3B/TFRC/ARPC1A/GIT2/SMAD3/HLA-F/SH3GL1/IL2RG/VPS37C/HLA-G/HLA-A/ZFYVE16/EGFR/ASAP1/ACTR3/AP2M1/HLA-B/HLA-E/CAPZA1/BIN1/CCR5/EHD3/PLD1/RAB11FIP1/CXCR4/CHMP6/ARRB1/ACAP1/CBLB/FOLR2/ARAP3/SNX2/KIF5C/WIPF1/PRKCI/CHMP2A/HSPA6/IL2RB/PML/ACAP2/USP8/CXCR2/ARPC5L/RUFY2/CHMP1B/GRK6/RAB11B/HSPA2/ARFGEF1/ACTR2/NEDD4L	53
KEGG	hsa04916	Melanogenesis	24/1378	101/8135	0.04836	0.1299	0.08539	WNT5B/MAPK3/PRKCB/TCF7/GSK3B/KIT/CREB3/WNT11/LEF1/FZD3/ADCY1/DCT/ADCY2/RAF1/CREB1/TCF7L2/FZD6/EP300/KRAS/FZD7/CAMK2B/CALML4/FZD2/NRAS	24
KEGG	hsa00071	Fatty acid degradation	12/1378	43/8135	0.04912	0.1309	0.08604	ALDH7A1/ECI2/ECHS1/ACSL5/HADH/ECI1/ACAT1/ALDH9A1/ALDH3A2/ACADM/ACOX1/ACAA2	12
KEGG	hsa04936	Alcoholic liver disease	32/1378	142/8135	0.05014	0.1315	0.08648	NFKBIA/MAP3K5/ALDH7A1/TBK1/FAS/TCF7/GSK3B/CXCL2/PRKAG1/PRKAB1/LEF1/IRF3/NFKB1/MAPK11/CHUK/SCD5/ALDH9A1/IL6/IRAK4/ALDH3A2/CXCL3/TRAF3/ACADM/ACOX1/IL17RC/PRKAA1/IKBKG/TCF7L2/MYD88/CXCL8/LPIN1/IL17RA	32
KEGG	hsa03020	RNA polymerase	10/1378	34/8135	0.05016	0.1315	0.08648	POLR2J/POLR2I/POLR2L/POLR3C/POLR2E/POLR2F/POLR2C/POLR1B/POLR2G/POLR1C	10
KEGG	hsa05142	Chagas disease	24/1378	102/8135	0.05348	0.1391	0.09148	NFKBIA/CCL5/MAPK3/FAS/CFLAR/SERPINE1/NFKB1/CD3E/IFNG/MAPK11/CHUK/PIK3CB/CD3D/IL6/ADCY1/IRAK4/CD247/PIK3CD/IKBKG/GNA14/MYD88/CD3G/CXCL8/PIK3CA	24
KEGG	hsa00240	Pyrimidine metabolism	15/1378	58/8135	0.0557	0.1438	0.09453	HDDC2/NME4/TK2/ENPP1/NME7/ENTPD4/NT5C2/RRM2/DPYS/NME3/TYMP/DCTD/CTPS1/TYMS/NT5E	15
KEGG	hsa03250	Viral life cycle - HIV-1	16/1378	63/8135	0.057	0.1449	0.09526	NUP153/APOBEC3C/CCR5/SAMHD1/CPSF7/RANBP2/CXCR4/CHMP6/SERINC5/CCNT2/APOBEC3B/PIN1/ELL2/KAT2B/EP300/CDK9	16
KEGG	hsa04623	Cytosolic DNA-sensing pathway	16/1378	63/8135	0.057	0.1449	0.09526	AIM2/NFKBIA/CXCL10/CCL5/ADAR/TBK1/POLR2L/POLR3C/POLR2E/POLR2F/IRF3/NFKB1/CHUK/IL6/IKBKG/POLR1C	16
KEGG	hsa04664	Fc epsilon RI signaling pathway	17/1378	68/8135	0.05796	0.1462	0.09614	MS4A2/MAPK3/PLCG2/ALOX5AP/FCER1A/SOS1/PLA2G4C/MAPK11/PIK3CB/RAC2/LAT/PIK3CD/RAF1/KRAS/LCP2/NRAS/PIK3CA	17
KEGG	hsa03013	Nucleocytoplasmic transport	25/1378	108/8135	0.05861	0.1467	0.09649	NXF3/NUP160/THOC2/NUP153/XPO6/KPNA2/THOC1/TPR/UBE2I/NUP50/SEC13/NMD3/RANBP2/NXF1/SNUPN/TNPO1/NUP210/KPNB1/NUP43/NDC1/KPNA1/NCBP2/KPNA3/NUP98/NUP62	25
KEGG	hsa04912	GnRH signaling pathway	22/1378	93/8135	0.05942	0.1477	0.09709	MAPK3/PRKCB/SOS1/EGFR/MAPK7/PLD1/PLA2G4C/ITPR2/MAPK11/HBEGF/EGR1/ADCY1/MAP3K3/CACNA1D/ADCY2/RAF1/KRAS/PTK2B/ATF4/CAMK2B/CALML4/NRAS	22
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1378	26/8135	0.05988	0.1477	0.09711	PIGT/GPAA1/PIGK/PIGA/PIGP/PIGH/PIGZ/PIGC	8
KEGG	hsa04926	Relaxin signaling pathway	29/1378	129/8135	0.06158	0.1508	0.09913	NFKBIA/MAPK3/SOS1/EGFR/CREB3/GNG3/GNG12/ARRB1/NFKB1/MAPK11/PIK3CB/NOS3/MMP13/ADCY1/VEGFA/GNB2/PIK3CD/ADCY2/RAF1/CREB1/COL4A1/ATF2/COL3A1/KRAS/COL4A2/ATF4/VEGFB/NRAS/PIK3CA	29
KEGG	hsa04071	Sphingolipid signaling pathway	27/1378	119/8135	0.06304	0.1532	0.1007	ADORA3/SPHK1/MS4A2/MAP3K5/MAPK3/FCER1A/PRKCB/CERS6/ASAH1/ROCK1/PLD1/CERS4/S1PR1/NFKB1/CERS2/ABCC1/MAPK11/PIK3CB/NOS3/RAC2/SGMS1/PIK3CD/RAF1/SGPL1/KRAS/NRAS/PIK3CA	27
KEGG	hsa04330	Notch signaling pathway	15/1378	59/8135	0.06347	0.1532	0.1007	NOTCH1/ADAM17/NOTCH4/RFNG/MAML1/PSENEN/RBPJ/JAG2/TLE3/HDAC1/APH1B/KAT2B/TLE2/EP300/APH1A	15
KEGG	hsa04211	Longevity regulating pathway	21/1378	89/8135	0.06592	0.1579	0.1038	INSR/CREB3/PRKAG1/PRKAB1/PPARG/CAT/NFKB1/PIK3CB/IGF1/ADCY1/ATG13/PRKAA1/PIK3CD/ADCY2/CREB1/ATF2/SESN1/KRAS/ATF4/NRAS/PIK3CA	21
KEGG	hsa04150	mTOR signaling pathway	34/1378	156/8135	0.06695	0.1592	0.1047	WNT5B/MAPK3/SLC7A5/PRKCB/SOS1/DDIT4/DEPTOR/GSK3B/INSR/RRAGA/WNT11/FZD3/SEC13/GRB10/PRR5L/CHUK/LRP5/PIK3CB/IGF1/LAMTOR2/MLST8/PRKAA1/PIK3CD/RAF1/RRAGD/FZD6/KRAS/RPS6KA1/FZD7/LPIN1/CAB39L/FZD2/NRAS/PIK3CA	34
KEGG	hsa04310	Wnt signaling pathway	36/1378	167/8135	0.06952	0.1642	0.108	WIF1/SFRP1/WNT5B/CHD8/SKP1/SMAD3/PRKCB/CBY1/TCF7/CTNNBIP1/GSK3B/WNT11/LEF1/CSNK2B/FZD3/LRP5/RAC2/MYC/CSNK1A1/DKK4/CXXC4/LGR5/FRAT1/CSNK1E/NLK/PPP3CA/TLE3/TCF7L2/CCND2/TLE2/FZD6/EP300/FZD7/SERPINF1/CAMK2B/FZD2	36
KEGG	hsa00920	Sulfur metabolism	4/1378	10/8135	0.07321	0.1709	0.1124	SELENBP1/SUOX/MPST/PAPSS1	4
KEGG	hsa03320	PPAR signaling pathway	18/1378	75/8135	0.0734	0.1709	0.1124	ACOX2/OLR1/SLC27A6/ACSL5/SLC27A5/RXRA/GK/PPARG/SCD5/SCP2/PCK2/ACADM/LPL/ACOX1/PLIN2/FABP7/FABP3/SORBS1	18
KEGG	hsa01240	Biosynthesis of cofactors	33/1378	153/8135	0.07902	0.1827	0.1202	GCH1/VKORC1/HPD/NME4/MTHFD2/HAAO/NME7/GUSB/FECH/DHRS3/MPI/PNPO/IDO1/NQO1/MOCS2/UROD/NME3/COQ6/UROS/LIPT1/AK1/GGH/AK6/DLD/UGT2B17/GGCX/ALDH3A2/NADSYN1/CTPS1/PMM1/PANK3/CPOX/COQ2	33
KEGG	hsa04520	Adherens junction	17/1378	71/8135	0.08172	0.1877	0.1234	MAPK3/SMAD3/PTPRF/TCF7/EGFR/BAIAP2/INSR/ERBB2/LEF1/CSNK2B/RAC2/NLK/ACP1/TCF7L2/EP300/ACTN1/SORBS1	17
KEGG	hsa00230	Purine metabolism	28/1378	128/8135	0.08652	0.1973	0.1297	HDDC2/NME4/ENPP1/NME7/PDE1A/ENTPD4/IMPDH2/NT5C2/ADK/PGM1/ADA/RRM2/DGUOK/NME3/NUDT9/FHIT/AK1/PNP/NPR2/AK6/ADCY1/GUK1/ADCY2/NT5E/PRPS1/PRPS2/AMPD3/PAPSS1	28
KEGG	hsa03420	Nucleotide excision repair	12/1378	47/8135	0.08832	0.2001	0.1315	CETN2/ERCC1/POLD2/RPA1/RPA3/POLD4/CCNH/DDB2/ERCC2/MNAT1/GTF2H3/RFC2	12
KEGG	hsa00051	Fructose and mannose metabolism	9/1378	33/8135	0.09287	0.2089	0.1374	AKR1B1/AKR1B10/MPI/SORD/PFKFB3/PFKM/GMDS/PMM1/ALDOC	9
KEGG	hsa04929	GnRH secretion	15/1378	64/8135	0.113	0.2522	0.1658	KCNN3/MAPK3/PRKCB/GPER1/ARRB1/ITPR2/PIK3CB/KCNN2/PIK3CD/CACNA1D/RAF1/GABBR1/KRAS/NRAS/PIK3CA	15
KEGG	hsa04672	Intestinal immune network for IgA production	12/1378	49/8135	0.1136	0.2522	0.1658	IL15RA/HLA-DRB4/IL15/TNFRSF17/CD28/ITGB7/CD40/CXCR4/IL6/HLA-DOB/HLA-DQB1/CD40LG	12
KEGG	hsa05152	Tuberculosis	37/1378	180/8135	0.1152	0.254	0.167	SPHK1/STAT1/JAK2/HLA-DRB4/MAPK3/RIPK2/RFX5/ATP6V0D1/MALT1/MRC2/BAD/ITGAX/JAK1/TCIRG1/NFKB1/CR1/IFNG/APAF1/MAPK11/IL6/IRAK4/HLA-DOB/HLA-DQB1/CASP9/PLA2R1/NOD2/PPP3CA/RAF1/CEBPG/CREB1/BCL10/EP300/MYD88/CEBPB/CAMK2B/NFYC/CALML4	37
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	30/1378	143/8135	0.1192	0.2611	0.1717	JARID2/WNT5B/JAK2/MAPK3/SMAD3/TCF7/GSK3B/BMP4/JAK1/WNT11/FZD3/ID4/PCGF1/MAPK11/PIK3CB/IGF1/MYC/KAT6A/PIK3CD/TCF3/RAF1/ID2/ID3/FZD6/INHBB/KRAS/FZD7/FZD2/NRAS/PIK3CA	30
KEGG	hsa05130	Pathogenic Escherichia coli infection	40/1378	197/8135	0.1206	0.2624	0.1725	NFKBIA/ACTR3B/MAPK3/ARPC1A/SEC24A/FAS/TUBB2B/BAIAP2/NCK2/ACTR3/CASP4/ARHGEF2/CYFIP2/ROCK1/F2R/CLDN11/NFKB1/TUBA4A/WIPF1/MAPK11/CHUK/TUBB6/IL6/TLR5/IRAK4/CASP9/NAIP/ABI1/TMED10/ARPC5L/LPAR2/CTTN/IKBKG/TUBB2A/PAK2/CYFIP1/MYD88/CXCL8/ACTR2/MYH10	40
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1378	30/8135	0.1217	0.2632	0.173	PCCB/CAT/MDH2/ACAT1/DLD/GRHPR/HYI/MDH1	8
KEGG	hsa00260	Glycine, serine and threonine metabolism	10/1378	40/8135	0.1268	0.2723	0.1791	CBS/ALDH7A1/SDS/GAMT/GCAT/GATM/DLD/GRHPR/PSPH/SRR	10
KEGG	hsa04141	Protein processing in endoplasmic reticulum	35/1378	171/8135	0.1282	0.2736	0.1799	MAP3K5/UBE2D4/SEC24A/SKP1/HERPUD1/SIL1/HSPH1/UBE2J1/LMAN2/DNAJC1/DNAJA1/SEC13/UBXN4/CRYAB/MBTPS1/ATF6/DAD1/MAN1C1/NGLY1/HSPA6/MAN1B1/UBQLN4/BAG1/SEC61A2/EDEM1/DDOST/DNAJC3/UBXN8/SSR2/XBP1/HSPA2/ATF4/HSPA5/SEL1L/DDIT3	35
KEGG	hsa04725	Cholinergic synapse	24/1378	113/8135	0.1364	0.2892	0.1902	JAK2/MAPK3/KCNQ1/PRKCB/CREB3/GNG3/GNG12/KCNJ2/ITPR2/CHRNA3/PIK3CB/PIK3R5/ADCY1/GNB2/PIK3CD/CACNA1D/ADCY2/CREB1/KRAS/KCNQ3/ATF4/CAMK2B/NRAS/PIK3CA	24
KEGG	hsa00052	Galactose metabolism	8/1378	31/8135	0.141	0.2935	0.193	AKR1B1/AKR1B10/G6PC3/B4GALT2/PGM1/PFKM/GAA/LCT	8
KEGG	hsa00410	beta-Alanine metabolism	8/1378	31/8135	0.141	0.2935	0.193	ALDH7A1/ECHS1/DPYS/ALDH9A1/ALDH3A2/ACOX1/ALDH6A1/ALDH3B1	8
KEGG	hsa04710	Circadian rhythm	8/1378	31/8135	0.141	0.2935	0.193	SKP1/RORA/PRKAG1/PRKAB1/CSNK1E/PRKAA1/CREB1/CRY1	8
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	9/1378	36/8135	0.1429	0.2947	0.1938	ENPP1/CD38/NT5C2/PNP/SIRT3/NAMPT/NADSYN1/NT5E/SIRT7	9
KEGG	hsa04216	Ferroptosis	10/1378	41/8135	0.1436	0.2947	0.1938	TFRC/SLC7A11/PRNP/ACSL5/GPX4/FTL/SLC39A8/CP/SLC39A14/VDAC3	10
KEGG	hsa04925	Aldosterone synthesis and secretion	21/1378	98/8135	0.1458	0.2947	0.1938	ATP1B1/PRKD2/PRKCB/PRKD3/CYP11A1/CREB3/KCNK3/ITPR2/ATP2B2/AGT/ADCY1/CAMK1/ATP2B4/CACNA1D/ADCY2/CREB1/ATF2/ATF4/CAMK2B/ATP2B1/CALML4	21
KEGG	hsa05231	Choline metabolism in cancer	21/1378	98/8135	0.1458	0.2947	0.1938	MAPK3/SLC22A4/PRKCB/SOS1/EGFR/EGF/DGKA/PLD1/PLA2G4C/DGKZ/PIK3CB/RAC2/RALGDS/PDGFB/HIF1A/PIK3CD/RAF1/KRAS/CHPT1/NRAS/PIK3CA	21
KEGG	hsa05140	Leishmaniasis	17/1378	77/8135	0.146	0.2947	0.1938	NFKBIA/STAT1/JAK2/HLA-DRB4/MAPK3/PRKCB/MARCKSL1/JAK1/NFKB1/CR1/IFNG/MAPK11/IRAK4/HLA-DOB/HLA-DQB1/MYD88/NCF1	17
KEGG	hsa04140	Autophagy - animal	29/1378	141/8135	0.1482	0.2973	0.1954	MAPK3/GABARAPL1/TBK1/GABARAPL2/CFLAR/MTMR4/DDIT4/BAD/DEPTOR/UVRAG/RRAGA/SUPT20H/ATG2B/PIK3CB/HMGB1/PRKCQ/ATG13/MLST8/HIF1A/PRKAA1/ATG4A/PIK3CD/RAF1/RRAGD/ATG12/KRAS/GABARAP/NRAS/PIK3CA	29
KEGG	hsa04720	Long-term potentiation	15/1378	67/8135	0.1514	0.3018	0.1984	MAPK3/PRKCB/GRIA2/ITPR2/ADCY1/PPP3CA/RAF1/EP300/KRAS/RPS6KA1/RAP1B/ATF4/CAMK2B/CALML4/NRAS	15
KEGG	hsa04540	Gap junction	19/1378	88/8135	0.1523	0.3018	0.1984	MAPK3/PRKCB/SOS1/TUBB2B/EGFR/EGF/MAPK7/HTR2B/ITPR2/TUBA4A/TUBB6/ADCY1/PDGFB/ADCY2/RAF1/CDK1/TUBB2A/KRAS/NRAS	19
KEGG	hsa00340	Histidine metabolism	6/1378	22/8135	0.1553	0.3061	0.2012	ALDH7A1/HDC/ALDH9A1/ALDH3A2/HNMT/ALDH3B1	6
KEGG	hsa00600	Sphingolipid metabolism	12/1378	52/8135	0.1585	0.3088	0.203	SPHK1/CERS6/ASAH1/CERS4/UGCG/HEXA/CERS2/NEU1/SGMS1/SGPL1/PSAP/CERK	12
KEGG	hsa00380	Tryptophan metabolism	10/1378	42/8135	0.1616	0.3088	0.203	ALDH7A1/HAAO/ECHS1/IDO1/CAT/HADH/ACAT1/DLD/ALDH9A1/ALDH3A2	10
KEGG	hsa04910	Insulin signaling pathway	28/1378	137/8135	0.1616	0.3088	0.203	PPP1R3C/MAPK3/SH2B2/PRKAR2A/PTPRF/SOS1/G6PC3/BAD/GSK3B/INSR/SOCS1/PRKAG1/EXOC7/PRKAB1/PYGM/CBLB/PRKCI/PIK3CB/PCK2/MKNK2/PRKAA1/PIK3CD/RAF1/KRAS/CALML4/NRAS/PIK3CA/SORBS1	28
KEGG	hsa04136	Autophagy - other	8/1378	32/8135	0.1617	0.3088	0.203	GABARAPL1/GABARAPL2/ATG2B/ATG13/MLST8/ATG4A/ATG12/GABARAP	8
KEGG	hsa05143	African trypanosomiasis	9/1378	37/8135	0.1622	0.3088	0.203	FAS/PRKCB/APOL1/IDO1/SELE/IFNG/IL6/HBB/MYD88	9
KEGG	hsa00562	Inositol phosphate metabolism	16/1378	73/8135	0.1623	0.3088	0.203	PLCG2/MTMR4/SYNJ1/PIKFYVE/MTMR6/PIK3C2B/PIK3CB/MTMR1/PLCE1/PLCD1/ISYNA1/PIK3CD/INPP5E/ALDH6A1/PIK3C2G/PIK3CA	16
KEGG	hsa05217	Basal cell carcinoma	14/1378	63/8135	0.1689	0.3195	0.2101	WNT5B/TCF7/GSK3B/BMP4/WNT11/LEF1/FZD3/DDB2/TCF7L2/CDKN1A/FZD6/FZD7/SMO/FZD2	14
KEGG	hsa04915	Estrogen signaling pathway	28/1378	138/8135	0.1718	0.3231	0.2125	MAPK3/SOS1/NCOA3/EGFR/KRT10/CREB3/GPER1/KRT14/ITPR2/PIK3CB/NOS3/HSPA6/HBEGF/ADCY1/PIK3CD/ADCY2/RAF1/GABBR1/CREB1/ATF2/HSPA2/KRAS/KRT33A/ATF4/KRT24/CALML4/NRAS/PIK3CA	28
KEGG	hsa04514	Cell adhesion molecules	30/1378	149/8135	0.173	0.3236	0.2127	HLA-C/CDH2/HLA-DRB4/HLA-F/HLA-G/HLA-A/PTPRF/PTPRC/CD8A/SDC1/NEO1/CTLA4/ITGAL/HLA-B/HLA-E/PECAM1/SELE/CD28/ITGB7/CD40/CLDN11/CDH5/HLA-DOB/HLA-DQB1/CADM3/CD58/CD2/VCAN/CD40LG/ICAM3	30
KEGG	hsa04934	Cushing syndrome	31/1378	155/8135	0.1783	0.3317	0.2181	WNT5B/MAPK3/TCF7/CDKN2C/EGFR/GSK3B/CDK4/CYP11A1/CREB3/WNT11/LEF1/KCNK3/FZD3/ITPR2/AGT/WDR5B/ADCY1/USP8/CACNA1D/ADCY2/CREB1/TCF7L2/CDKN1A/FZD6/ATF2/RAP1B/FZD7/ATF4/CAMK2B/FH/FZD2	31
KEGG	hsa04920	Adipocytokine signaling pathway	15/1378	69/8135	0.1804	0.3338	0.2195	NFKBIA/TNFRSF1B/JAK2/G6PC3/ACSL5/PRKAG1/RXRA/PRKAB1/NFKB1/CHUK/PCK2/PRKCQ/AGRP/PRKAA1/IKBKG	15
KEGG	hsa00650	Butanoate metabolism	7/1378	28/8135	0.1838	0.3381	0.2223	ECHS1/ACSM5/BDH2/HMGCL/HADH/OXCT1/ACAT1	7
KEGG	hsa00983	Drug metabolism - other enzymes	17/1378	80/8135	0.1864	0.3411	0.2243	GSTA4/NME4/TK2/NME7/GUSB/IMPDH2/CES2/RRM2/DPYS/MGST3/GSTM4/NME3/TYMP/UGT2B17/GSTM5/GSTM3/NAT2	17
KEGG	hsa01230	Biosynthesis of amino acids	16/1378	75/8135	0.1911	0.3478	0.2287	CBS/SDS/GOT1/ENO2/PC/PFKM/ASS1/PSPH/CPS1/ALDOC/PYCR1/PRPS1/ALDH18A1/PRPS2/RPE/ASNS	16
KEGG	hsa05146	Amoebiasis	21/1378	102/8135	0.1938	0.3507	0.2306	LAMC3/PRKCB/CXCL2/SERPINB6/LAMA5/HSPB1/NFKB1/IFNG/PIK3CB/IL6/ADCY1/CXCL3/PIK3CD/CTSG/COL4A1/GNA14/COL3A1/ACTN1/CXCL8/COL4A2/PIK3CA	21
KEGG	hsa04611	Platelet activation	25/1378	124/8135	0.1974	0.3552	0.2336	PTGS1/TBXAS1/RASGRP1/MAPK3/PLCG2/ROCK1/F2R/PPP1R12A/PLA2G4C/ITPR2/MAPK11/PRKCI/PIK3CB/NOS3/PIK3R5/ADCY1/ARHGAP35/TLN2/PIK3CD/ADCY2/RASGRP2/COL3A1/LCP2/RAP1B/PIK3CA	25
KEGG	hsa04962	Vasopressin-regulated water reabsorption	10/1378	44/8135	0.2005	0.3589	0.236	DCTN6/CREB3/DCTN2/DYNC1I1/DYNC1H1/VAMP2/AQP2/CREB1/RAB11B/DYNC2LI1	10
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1378	14/8135	0.2018	0.3593	0.2363	B4GALT2/ST3GAL2/FUT8/B4GALT3	4
KEGG	hsa00513	Various types of N-glycan biosynthesis	9/1378	39/8135	0.204	0.3614	0.2376	MGAT4C/B4GALT2/HEXA/DAD1/MAN1C1/MAN1B1/FUT8/DDOST/B4GALT3	9
KEGG	hsa00531	Glycosaminoglycan degradation	5/1378	19/8135	0.2083	0.367	0.2413	GUSB/NAGLU/HEXA/SGSH/ARSB	5
KEGG	hsa00510	N-Glycan biosynthesis	11/1378	50/8135	0.2162	0.3769	0.2478	MGAT4C/B4GALT2/DPM3/DPAGT1/DAD1/MAN1C1/MAN1B1/FUT8/DDOST/ALG6/B4GALT3	11
KEGG	hsa04979	Cholesterol metabolism	11/1378	50/8135	0.2162	0.3769	0.2478	LIPC/LRPAP1/APOE/APOC1/TSPO/SORT1/LIPA/LPL/VDAC3/NPC1/VAPA	11
KEGG	hsa05323	Rheumatoid arthritis	19/1378	93/8135	0.2188	0.3794	0.2495	HLA-DRB4/CCL5/ANGPT1/ATP6V0D1/IL15/CTLA4/ITGAL/TNFRSF11A/CXCL2/CD28/TCIRG1/IFNG/IL6/HLA-DOB/HLA-DQB1/VEGFA/ATP6V0E2/CXCL3/CXCL8	19
KEGG	hsa02010	ABC transporters	10/1378	45/8135	0.2213	0.3819	0.2511	TAP1/ABCC10/ABCC4/ABCA8/ABCA3/ABCC1/ABCA2/TAP2/ABCC8/ABCB1	10
KEGG	hsa00561	Glycerolipid metabolism	13/1378	61/8135	0.2238	0.3841	0.2526	AKR1B1/AKR1B10/ALDH7A1/LIPC/AGPAT1/AGPAT5/DGKA/GK/DGKZ/ALDH9A1/ALDH3A2/LPL/LPIN1	13
KEGG	hsa04921	Oxytocin signaling pathway	30/1378	154/8135	0.2264	0.3866	0.2542	MAPK3/MYL6B/PRKCB/CD38/EGFR/MAPK7/PRKAG1/PRKAB1/ROCK1/KCNJ2/PPP1R12A/PLA2G4C/ITPR2/NPR2/NOS3/PIK3R5/ADCY1/PPP3CA/CACNB2/CAMK1/PRKAA1/CACNA1D/ADCY2/RAF1/CDKN1A/CACNA2D3/KRAS/CAMK2B/CALML4/NRAS	30
KEGG	hsa04360	Axon guidance	35/1378	182/8135	0.2286	0.3884	0.2554	WNT5B/SEMA4D/MAPK3/UNC5C/PLCG2/LIMK2/SEMA4A/SEMA3A/NEO1/NCK2/GSK3B/SEMA4C/EFNA5/ROCK1/FZD3/CXCR4/SSH3/EPHB6/SEMA3F/PIK3CB/EFNB1/RAC2/EPHA4/SEMA3E/PPP3CA/PIK3CD/RAF1/PLXNA1/PAK2/KRAS/SMO/CAMK2B/LRIG2/NRAS/PIK3CA	35
KEGG	hsa00030	Pentose phosphate pathway	7/1378	30/8135	0.2359	0.3975	0.2614	RBKS/PGM1/PFKM/ALDOC/PRPS1/PRPS2/RPE	7
KEGG	hsa00270	Cysteine and methionine metabolism	11/1378	51/8135	0.2364	0.3975	0.2614	CBS/BHMT2/SDS/GOT1/DNMT1/SMS/MDH2/MPST/AHCY/SRM/MDH1	11
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1378	15/8135	0.2407	0.4025	0.2646	B3GALNT1/FUT1/HEXA/ST3GAL2	4
KEGG	hsa00100	Steroid biosynthesis	5/1378	20/8135	0.2417	0.4025	0.2646	LBR/SC5D/LIPA/DHCR24/DHCR7	5
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	21/1378	106/8135	0.2486	0.4115	0.2706	MAPK3/PRKCB/PTH1R/EGFR/CREB3/RXRA/PLD1/ARRB1/ITPR2/LRP5/MMP13/HBEGF/EGR1/ADCY1/ADCY2/RAF1/AKAP13/CREB1/CDKN1A/ATF2/ATF4	21
KEGG	hsa01212	Fatty acid metabolism	12/1378	57/8135	0.2496	0.4115	0.2706	ECHS1/TECR/MECR/ACSL5/HADH/ACAT1/SCD5/SCP2/ACADM/ACOX1/ACAA2/MCAT	12
KEGG	hsa00350	Tyrosine metabolism	8/1378	36/8135	0.2566	0.4209	0.2768	FAH/HPD/GOT1/COMT/GSTZ1/DCT/ALDH3B1/TH	8
KEGG	hsa00310	Lysine degradation	13/1378	63/8135	0.2614	0.4267	0.2806	ALDH7A1/ECHS1/EZH2/SETMAR/HADH/SMYD2/ACAT1/DLD/SETD1B/ALDH9A1/ALDH3A2/SETD2/SUV39H2	13
KEGG	hsa05310	Asthma	7/1378	31/8135	0.2635	0.428	0.2814	MS4A2/HLA-DRB4/FCER1A/CD40/HLA-DOB/HLA-DQB1/CD40LG	7
KEGG	hsa00514	Other types of O-glycan biosynthesis	10/1378	47/8135	0.2653	0.4289	0.282	GALNT11/GALNT10/EOGT/B4GALT2/RFNG/POFUT1/GALNT3/OGT/C1GALT1C1/B4GALT3	10
KEGG	hsa00770	Pantothenate and CoA biosynthesis	5/1378	21/8135	0.2764	0.4447	0.2924	ENPP1/DPYS/ALDH3A2/PANK3/VNN1	5
KEGG	hsa04070	Phosphatidylinositol signaling system	19/1378	97/8135	0.2799	0.4481	0.2946	PLCG2/PRKCB/MTMR4/SYNJ1/PIKFYVE/DGKA/MTMR6/PIK3C2B/DGKZ/ITPR2/PIK3CB/MTMR1/PLCE1/PLCD1/PIK3CD/INPP5E/PIK3C2G/CALML4/PIK3CA	19
KEGG	hsa04622	RIG-I-like receptor signaling pathway	14/1378	70/8135	0.291	0.4608	0.303	NFKBIA/RNF125/CXCL10/TBK1/IRF3/NFKB1/MAPK11/CHUK/PIN1/TRAF3/CYLD/IKBKG/ATG12/CXCL8	14
KEGG	hsa00640	Propanoate metabolism	7/1378	32/8135	0.292	0.4608	0.303	ECHS1/BCKDHB/PCCB/DLD/ACOX1/SUCLG1/ALDH6A1	7
KEGG	hsa04215	Apoptosis - multiple species	7/1378	32/8135	0.292	0.4608	0.303	BIRC3/BIRC2/BIRC7/APAF1/CASP9/BIRC5/NGFR	7
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	19/1378	98/8135	0.296	0.465	0.3057	PLCG2/PRKCB/PRKCH/HTR2B/PTGER4/NTRK1/PLA2G4C/ITPR2/MAPK11/PIK3CB/IGF1/ADCY1/PRKCQ/PIK3CD/ADCY2/TRPV2/CAMK2B/CALML4/PIK3CA	19
KEGG	hsa04260	Cardiac muscle contraction	17/1378	87/8135	0.2983	0.4663	0.3066	ATP1B1/COX7A1/ATP2A3/UQCR10/ASPH/CYC1/MYL3/COX6C/COX8A/COX6A1/COX5B/MYL4/CACNB2/UQCRQ/CACNA1D/CACNA2D3/UQCRC1	17
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1378	27/8135	0.3018	0.4697	0.3088	B4GALT2/B3GALNT1/FUT1/ABO/FUT4/B4GALT3	6
KEGG	hsa04022	cGMP-PKG signaling pathway	31/1378	167/8135	0.3163	0.4898	0.3221	ADORA3/ATP1B1/MAPK3/ATP2A3/SLC25A4/GTF2IRD1/BAD/INSR/CREB3/ROCK1/ADRB2/PPP1R12A/ITPR2/NPR2/ATP2B2/NOS3/PIK3R5/ADCY1/PPP3CA/KCNJ8/ATP2B4/CACNA1D/ADCY2/RAF1/CREB1/VDAC3/ATF2/ATF4/KCNMB2/ATP2B1/CALML4	31
KEGG	hsa03410	Base excision repair	7/1378	33/8135	0.3211	0.4928	0.324	PARP3/POLD2/TDG/POLD4/MPG/PARP4/HMGB1	7
KEGG	hsa04130	SNARE interactions in vesicular transport	7/1378	33/8135	0.3211	0.4928	0.324	BNIP1/SEC22B/VTI1B/VAMP3/VAMP7/USE1/VAMP2	7
KEGG	hsa04137	Mitophagy - animal	14/1378	72/8135	0.3301	0.5043	0.3316	FIS1/GABARAPL1/TBK1/GABARAPL2/PINK1/CSNK2B/USP8/UBB/OPTN/HIF1A/KRAS/ATF4/GABARAP/NRAS	14
KEGG	hsa00590	Arachidonic acid metabolism	12/1378	61/8135	0.3333	0.5068	0.3332	HPGDS/LTC4S/PTGS1/TBXAS1/EPHX2/PLA2G2D/GPX3/GPX1/PLA2G4C/AKR1C3/PTGDS/CBR1	12
KEGG	hsa00010	Glycolysis / Gluconeogenesis	13/1378	67/8135	0.3422	0.5157	0.3391	ALDH7A1/G6PC3/PGM1/ENO2/PFKM/DLD/ALDH9A1/PCK2/ALDH3A2/PDHB/ALDOC/ALDH3B1/ADPGK	13
KEGG	hsa05171	Coronavirus disease - COVID-19	42/1378	232/8135	0.3422	0.5157	0.3391	NFKBIA/CXCL10/C7/STAT1/MAPK3/ADAR/PLCG2/TBK1/PRKCB/ADAM17/EGFR/TYK2/CFD/JAK1/IRF3/RPS8/RPL12/NFKB1/RPS11/MAPK11/CHUK/PIK3CB/IL6/HBEGF/RPL10A/IRAK4/RPS5/TRAF3/MBL2/RPL27A/PIK3CD/RPL8/IKBKG/IL6R/RPL19/OAS2/MYD88/CXCL8/TLR8/RPL35A/PIK3CA/RPLP0	42
KEGG	hsa04024	cAMP signaling pathway	40/1378	221/8135	0.3477	0.5158	0.3391	NFKBIA/ATP1B1/FXYD1/SOX9/MAPK3/ATP2A3/BAD/ABCC4/CREB3/ROCK1/PLD1/GRIA2/F2R/ADRB2/NFKB1/PPP1R12A/ARAP3/ATP2B2/PIK3CB/RAC2/GHSR/ADCY1/NPY1R/PLCE1/SSTR5/ACOX1/ATP2B4/PIK3CD/CACNA1D/ADCY2/RAF1/GABBR1/CREB1/EP300/RAP1B/CAMK2B/BDNF/ATP2B1/CALML4/PIK3CA	40
KEGG	hsa03060	Protein export	5/1378	23/8135	0.3482	0.5158	0.3391	SPCS3/SEC11A/SEC61A2/SRP54/HSPA5	5
KEGG	hsa03430	Mismatch repair	5/1378	23/8135	0.3482	0.5158	0.3391	POLD2/RPA1/RPA3/POLD4/RFC2	5
KEGG	hsa03022	Basal transcription factors	9/1378	45/8135	0.3492	0.5158	0.3391	GTF2IRD1/TAF10/GTF2A2/CCNH/TAF9B/TAF7/ERCC2/MNAT1/GTF2H3	9
KEGG	hsa00040	Pentose and glucuronate interconversions	7/1378	34/8135	0.3507	0.5158	0.3391	AKR1B1/CRYL1/AKR1B10/GUSB/SORD/UGT2B17/RPE	7
KEGG	hsa05410	Hypertrophic cardiomyopathy	17/1378	90/8135	0.3516	0.5158	0.3391	SGCA/ATP2A3/SGCG/SGCB/ITGA5/PRKAG1/PRKAB1/MYL3/ITGB7/AGT/IGF1/IL6/CACNB2/PRKAA1/CACNA1D/ITGB5/CACNA2D3	17
KEGG	hsa04610	Complement and coagulation cascades	16/1378	85/8135	0.3639	0.5295	0.3482	C7/PROS1/CLU/SERPINA1/SERPINA5/ITGAX/SERPINE1/CFD/TFPI/CFI/F8/F2R/CR1/C4BPB/MBL2/CD59	16
KEGG	hsa00511	Other glycan degradation	4/1378	18/8135	0.3642	0.5295	0.3482	FUCA1/MAN2B2/HEXA/NEU1	4
KEGG	hsa04670	Leukocyte transendothelial migration	21/1378	114/8135	0.3732	0.5403	0.3553	PLCG2/PRKCB/ITK/ITGAL/PECAM1/ROCK1/CXCR4/CLDN11/CDH5/MAPK11/PIK3CB/RAC2/TXK/ARHGAP35/PIK3CD/RHOH/ACTN1/PTK2B/RAP1B/PIK3CA/NCF1	21
KEGG	hsa04911	Insulin secretion	16/1378	86/8135	0.3828	0.5517	0.3627	ATP1B1/KCNN3/PRKCB/CREB3/ADCY1/ABCC8/VAMP2/KCNN2/CACNA1D/ADCY2/CREB1/CCKAR/ATF2/ATF4/CAMK2B/KCNMB2	16
KEGG	hsa05031	Amphetamine addiction	13/1378	69/8135	0.3844	0.5517	0.3627	SLC18A2/PRKCB/CREB3/GRIA2/PPP3CA/HDAC1/CACNA1D/CREB1/ATF2/ATF4/CAMK2B/TH/CALML4	13
KEGG	hsa04973	Carbohydrate digestion and absorption	9/1378	47/8135	0.401	0.5732	0.3769	ATP1B1/PRKCB/G6PC3/PIK3CB/SLC2A5/PIK3CD/CACNA1D/LCT/PIK3CA	9
KEGG	hsa04530	Tight junction	30/1378	169/8135	0.42	0.5965	0.3922	ACTR3B/MAP3K5/ARPC1A/MYL6B/MICALL2/ACTR3/RAP2C/CDK4/PRKAG1/ERBB2/PRKAB1/ARHGEF2/ROCK1/CLDN11/TUBA4A/PRKCI/RAB13/RAPGEF6/LLGL2/AMOTL2/ARPC5L/PRKAA1/NF2/CTTN/CACNA1D/TJP2/ACTN1/ACTR2/MYH10/NEDD4L	30
KEGG	hsa04512	ECM-receptor interaction	16/1378	88/8135	0.4209	0.5965	0.3922	LAMC3/THBS4/SDC1/ITGA5/HMMR/CHAD/ITGB7/LAMA5/CD44/COMP/SV2B/COL6A3/THBS2/ITGB5/COL4A1/COL4A2	16
KEGG	hsa04350	TGF-beta signaling pathway	17/1378	94/8135	0.4252	0.6	0.3945	MAPK3/SKP1/SMAD3/ZFYVE16/NEO1/BMP4/GDF5/ROCK1/ID4/IFNG/MYC/NBL1/TGIF2/ID2/ID3/EP300/INHBB	17
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/1378	77/8135	0.4318	0.6067	0.3989	SGCA/CDH2/ATP2A3/SGCG/SGCB/TCF7/ITGA5/LEF1/ITGB7/CACNB2/CACNA1D/ITGB5/TCF7L2/CACNA2D3	14
KEGG	hsa03040	Spliceosome	26/1378	147/8135	0.438	0.6128	0.4029	LSM4/SNRNP40/THOC2/SF3B1/THOC1/LSM3/TCERG1/HNRNPK/DDX46/DDX23/SF3B5/HSPA6/LSM5/SRSF4/BUD31/HNRNPA1/SRSF8/PPIE/SNRPD2/TXNL4A/NCBP2/HSPA2/U2SURP/PUF60/PPIH/LSM2	26
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1378	20/8135	0.4467	0.6224	0.4092	UST/CHST15/B4GALT7/CHST12	4
KEGG	hsa04922	Glucagon signaling pathway	19/1378	107/8135	0.4503	0.6248	0.4108	SIK1/G6PC3/CREB3/PRKAG1/PRKAB1/PYGM/PFKM/ITPR2/PCK2/PPP3CA/PDHB/PRKAA1/ADCY2/CREB1/ATF2/EP300/ATF4/CAMK2B/CALML4	19
KEGG	hsa05030	Cocaine addiction	9/1378	49/8135	0.453	0.6259	0.4116	SLC18A2/CREB3/GRIA2/NFKB1/CREB1/ATF2/ATF4/BDNF/TH	9
KEGG	hsa00730	Thiamine metabolism	3/1378	15/8135	0.4794	0.6597	0.4338	THTPA/AK1/ACP1	3
KEGG	hsa00062	Fatty acid elongation	5/1378	27/8135	0.4919	0.6713	0.4414	ECHS1/TECR/MECR/HADH/ACAA2	5
KEGG	hsa04966	Collecting duct acid secretion	5/1378	27/8135	0.4919	0.6713	0.4414	ATP6V0D1/SLC12A7/TCIRG1/CA2/ATP6V0E2	5
KEGG	hsa04918	Thyroid hormone synthesis	13/1378	75/8135	0.5117	0.6955	0.4573	ATP1B1/PRKCB/GPX3/CREB3/GPX1/ITPR2/ADCY1/ADCY2/CREB1/ATF2/ASGR1/ATF4/HSPA5	13
KEGG	hsa00360	Phenylalanine metabolism	3/1378	16/8135	0.5252	0.7058	0.464	HPD/GOT1/ALDH3B1	3
KEGG	hsa00220	Arginine biosynthesis	4/1378	22/8135	0.5256	0.7058	0.464	GOT1/ASS1/NOS3/CPS1	4
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/1378	22/8135	0.5256	0.7058	0.464	PMVK/ACAT1/DHDDS/MVK	4
KEGG	hsa04930	Type II diabetes mellitus	8/1378	46/8135	0.5285	0.7068	0.4647	MAPK3/INSR/SOCS1/PIK3CB/ABCC8/PIK3CD/CACNA1D/PIK3CA	8
KEGG	hsa05133	Pertussis	13/1378	76/8135	0.5324	0.7092	0.4663	IRF1/MAPK3/ITGA5/IRF3/NFKB1/MAPK11/IL6/IRAK4/C4BPB/NOD1/MYD88/CXCL8/CALML4	13
KEGG	hsa04120	Ubiquitin mediated proteolysis	24/1378	142/8135	0.5402	0.7167	0.4712	BIRC3/UBE2D4/FBXW7/SKP1/TRIP12/UBE2J1/BIRC2/BIRC7/SOCS1/UBE2I/HERC1/CBLB/UBE2E3/DET1/UBE2M/PML/CDC20/UBB/DDB2/UBE2L6/TRIM32/CUL2/UBR5/NEDD4L	24
KEGG	hsa04727	GABAergic synapse	15/1378	89/8135	0.553	0.728	0.4786	GABARAPL1/GABARAPL2/PRKCB/GABRB1/SLC38A2/GNG3/GABRA4/GNG12/SLC38A1/ADCY1/GNB2/CACNA1D/ADCY2/GABBR1/GABARAP	15
KEGG	hsa04927	Cortisol synthesis and secretion	11/1378	65/8135	0.5531	0.728	0.4786	CYP11A1/CREB3/KCNK3/ITPR2/AGT/ADCY1/CACNA1D/ADCY2/CREB1/ATF2/ATF4	11
KEGG	hsa05017	Spinocerebellar ataxia	24/1378	143/8135	0.5553	0.728	0.4786	MAP3K5/ATP2A3/SLC25A4/RORA/PRKCB/FGF14/PUM2/ATXN10/PSMC2/GRIA2/ATG2B/ITPR2/PSMB6/PIK3CB/PSMC3/RBPJ/PSMD8/ATG13/PSMB5/KAT5/PIK3CD/VDAC3/XBP1/PIK3CA	24
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	4/1378	23/8135	0.563	0.7312	0.4808	ATP1B1/PCK2/CA2/MDH1	4
KEGG	hsa00450	Selenocompound metabolism	3/1378	17/8135	0.5686	0.7312	0.4808	SEPHS1/TXNRD2/PAPSS1	3
KEGG	hsa00910	Nitrogen metabolism	3/1378	17/8135	0.5686	0.7312	0.4808	CA12/CPS1/CA2	3
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	25/1378	150/8135	0.5702	0.7312	0.4808	SCN1B/ATP1B1/MAPK3/ATP2A3/KCNQ1/CREB3/MYL3/ADRB2/ATP2B2/AGT/MAPK11/PIK3R5/ADCY1/MYL4/CACNB2/ATP2B4/CACNA1D/ADCY2/CREB1/ATF2/CACNA2D3/ATF4/CAMK2B/ATP2B1/CALML4	25
KEGG	hsa04914	Progesterone-mediated oocyte maturation	17/1378	102/8135	0.5709	0.7312	0.4808	CDC25B/MAPK3/CCNA2/STK10/CCNB2/MAPK11/PIK3CB/IGF1/CCNB1/ADCY1/PIK3CD/ADCY2/RAF1/CDK1/KRAS/RPS6KA1/PIK3CA	17
KEGG	hsa04972	Pancreatic secretion	17/1378	102/8135	0.5709	0.7312	0.4808	ATP1B1/CPA3/ATP2A3/KCNQ1/PRKCB/PLA2G2D/CD38/CLCA2/ITPR2/ATP2B2/ADCY1/CA2/ATP2B4/ADCY2/CCKAR/RAP1B/ATP2B1	17
KEGG	hsa04390	Hippo signaling pathway	26/1378	157/8135	0.5844	0.7427	0.4883	WNT5B/BIRC3/SMAD3/TCF7/SERPINE1/GSK3B/BIRC2/BMP4/GDF5/WNT11/LEF1/FZD3/YWHAH/PRKCI/TP53BP2/MYC/LLGL2/BIRC5/CSNK1E/NF2/ID2/TCF7L2/CCND2/FZD6/FZD7/FZD2	26
KEGG	hsa00512	Mucin type O-glycan biosynthesis	6/1378	36/8135	0.5866	0.7427	0.4883	GALNT11/GALNT10/GCNT3/ST3GAL2/GALNT3/C1GALT1C1	6
KEGG	hsa03030	DNA replication	6/1378	36/8135	0.5866	0.7427	0.4883	POLD2/DNA2/RPA1/RPA3/POLD4/RFC2	6
KEGG	hsa00053	Ascorbate and aldarate metabolism	5/1378	30/8135	0.5916	0.7462	0.4906	ALDH7A1/GUSB/UGT2B17/ALDH9A1/ALDH3A2	5
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1378	49/8135	0.605	0.7545	0.4961	CYB5R1/GNPDA1/MPI/PGM1/HEXA/GMDS/CYB5R3/PMM1	8
KEGG	hsa00565	Ether lipid metabolism	8/1378	49/8135	0.605	0.7545	0.4961	PLA2G2D/PLD3/PLA2G7/PLD1/PLA2G4C/AGPS/LPCAT4/CHPT1	8
KEGG	hsa00564	Glycerophospholipid metabolism	16/1378	98/8135	0.6068	0.7545	0.4961	PNPLA6/PEMT/AGPAT1/PLA2G2D/PLA2G15/AGPAT5/DGKA/PLD3/PLD1/TAZ/PLA2G4C/DGKZ/PLA1A/LPCAT4/LPIN1/CHPT1	16
KEGG	hsa00860	Porphyrin metabolism	7/1378	43/8135	0.6093	0.7545	0.4961	GUSB/FECH/UROD/UROS/UGT2B17/CP/CPOX	7
KEGG	hsa00061	Fatty acid biosynthesis	3/1378	18/8135	0.6095	0.7545	0.4961	MECR/ACSL5/MCAT	3
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/1378	37/8135	0.6149	0.7584	0.4986	GOT1/DDO/ASRGL1/ASS1/CPS1/ASNS	6
KEGG	hsa04923	Regulation of lipolysis in adipocytes	9/1378	56/8135	0.6243	0.7672	0.5044	PTGS1/INSR/ADRB2/PIK3CB/ADCY1/NPY1R/PIK3CD/ADCY2/PIK3CA	9
KEGG	hsa05110	Vibrio cholerae infection	8/1378	50/8135	0.629	0.7701	0.5063	PLCG2/ATP6V0D1/KCNQ1/KDELR3/TCIRG1/ATP6V0E2/SEC61A2/TJP2	8
KEGG	hsa04924	Renin secretion	11/1378	69/8135	0.6376	0.7748	0.5095	PDE1A/KCNJ2/PTGER4/ADRB2/CLCA2/ITPR2/AGT/PPP3CA/CACNA1D/CREB1/CALML4	11
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	11/1378	69/8135	0.6376	0.7748	0.5095	HPGDS/GSTA4/EPHX1/MGST3/GSTM4/UGT2B17/GSTM5/SULT1A2/GSTM3/NAT2/CBR1	11
KEGG	hsa04114	Oocyte meiosis	21/1378	131/8135	0.6463	0.7826	0.5145	AR/MAPK3/SKP1/PTTG1/YWHAH/ITPR2/CCNB2/MAPK11/IGF1/CCNB1/ADCY1/CDC20/PPP3CA/SMC1A/ADCY2/CDK1/RPS6KA1/CAMK2B/PTTG2/CALML4/FBXO5	21
KEGG	hsa04913	Ovarian steroidogenesis	8/1378	51/8135	0.6523	0.787	0.5174	INSR/HSD17B1/CYP11A1/PLA2G4C/IGF1/AKR1C3/ADCY1/ADCY2	8
KEGG	hsa04728	Dopaminergic synapse	21/1378	132/8135	0.6607	0.7942	0.5222	SLC18A2/PRKCB/COMT/GSK3B/CREB3/GNG3/GNG12/GRIA2/ARRB1/ITPR2/KIF5C/MAPK11/GNB2/PPP3CA/CACNA1D/CREB1/ATF2/ATF4/CAMK2B/TH/CALML4	21
KEGG	hsa04152	AMPK signaling pathway	19/1378	120/8135	0.6651	0.7967	0.5238	CCNA2/G6PC3/INSR/CREB3/PRKAG1/PRKAB1/PPARG/PFKFB3/PFKM/PIK3CB/IGF1/SCD5/PCK2/PRKAA1/PIK3CD/CREB1/RAB11B/CAB39L/PIK3CA	19
KEGG	hsa04371	Apelin signaling pathway	22/1378	139/8135	0.6726	0.8006	0.5264	SPHK1/MAPK3/SMAD3/SERPINE1/PRKAG1/PRKAB1/GNG3/GNG12/MYL3/ITPR2/NOS3/PIK3R5/EGR1/ADCY1/GNB2/MYL4/PRKAA1/ADCY2/RAF1/KRAS/CALML4/NRAS	22
KEGG	hsa03450	Non-homologous end-joining	2/1378	13/8135	0.6732	0.8006	0.5264	DCLRE1C/RAD50	2
KEGG	hsa05414	Dilated cardiomyopathy	15/1378	96/8135	0.6768	0.802	0.5273	SGCA/ATP2A3/SGCG/SGCB/ITGA5/MYL3/ITGB7/AGT/IGF1/ADCY1/CACNB2/CACNA1D/ADCY2/ITGB5/CACNA2D3	15
KEGG	hsa03050	Proteasome	7/1378	46/8135	0.6828	0.8063	0.5301	PSMB9/PSMC2/IFNG/PSMB6/PSMC3/PSMD8/PSMB5	7
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1378	78/8135	0.6895	0.8113	0.5335	HPGDS/GSTA4/EPHX1/AKR7A3/MGST3/GSTM4/AKR7A2/UGT2B17/GSTM5/GSTM3/CBR1/ALDH3B1	12
KEGG	hsa04217	Necroptosis	25/1378	159/8135	0.6924	0.8114	0.5335	TNFAIP3/STAT1/BIRC3/JAK2/SLC25A4/FAS/TRAF5/CFLAR/TYK2/BIRC2/JAK1/CHMP6/PYGM/STAT4/PLA2G4C/IFNG/FTL/CHMP2A/HMGB1/CYLD/CHMP1B/VDAC3/STAT5A/CAMK2B/USP21	25
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/1378	27/8135	0.6945	0.8114	0.5335	TECR/SCD5/SCP2/ACOX1	4
KEGG	hsa04730	Long-term depression	9/1378	60/8135	0.7082	0.8246	0.5422	MAPK3/PRKCB/GRIA2/PLA2G4C/ITPR2/IGF1/RAF1/KRAS/NRAS	9
KEGG	hsa03460	Fanconi anemia pathway	8/1378	54/8135	0.7166	0.8314	0.5467	ERCC1/ATR/FANCI/RPA1/RPA3/RMI1/BRCA2/RAD51C	8
KEGG	hsa00140	Steroid hormone biosynthesis	9/1378	61/8135	0.7272	0.8408	0.5528	HSD11B2/COMT/HSD17B1/CYP11A1/CYP7B1/STS/UGT2B17/AKR1C3/AKR1C4	9
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1378	15/8135	0.7494	0.8619	0.5667	HEXA/ST3GAL2	2
KEGG	hsa00500	Starch and sucrose metabolism	5/1378	36/8135	0.7536	0.8619	0.5667	ENPP1/G6PC3/PGM1/PYGM/GAA	5
KEGG	hsa04340	Hedgehog signaling pathway	8/1378	56/8135	0.7548	0.8619	0.5667	GAS1/SCUBE2/GSK3B/ARRB1/CSNK1A1/CSNK1E/CCND2/SMO	8
KEGG	hsa04724	Glutamatergic synapse	17/1378	114/8135	0.7558	0.8619	0.5667	MAPK3/PRKCB/SLC38A2/GNG3/GNG12/PLD1/GRIA2/SLC38A1/PLA2G4C/ITPR2/ADCY1/GNB2/HOMER3/PPP3CA/CACNA1D/ADCY2/SLC1A1	17
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/1378	23/8135	0.7734	0.879	0.5779	B4GALT2/FUT4/B4GALT3	3
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/1378	16/8135	0.7815	0.8851	0.582	FMO3/FMO4	2
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1378	24/8135	0.7984	0.9	0.5917	EXT2/EXTL2/B4GALT7	3
KEGG	hsa00982	Drug metabolism - cytochrome P450	10/1378	72/8135	0.8	0.9	0.5917	HPGDS/GSTA4/MGST3/GSTM4/UGT2B17/GSTM5/GSTM3/FMO3/FMO4/ALDH3B1	10
KEGG	hsa03018	RNA degradation	11/1378	79/8135	0.8054	0.903	0.5937	LSM4/WDR61/EXOSC7/LSM3/ENO2/PABPC3/PFKM/DCP2/LSM5/EDC4/LSM2	11
KEGG	hsa04970	Salivary secretion	13/1378	93/8135	0.8158	0.91	0.5983	ATP1B1/PRKCB/CD38/ADRB2/ITPR2/ATP2B2/ADCY1/VAMP2/ATP2B4/ADCY2/CST4/ATP2B1/CALML4	13
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1378	53/8135	0.8171	0.91	0.5983	ATP1B1/PRKCB/PTH1R/AP2M1/ATP2B2/ATP2B4/ATP2B1	7
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1378	25/8135	0.821	0.9113	0.5992	PLA2G2D/PLA2G4C/ACOX1	3
KEGG	hsa04270	Vascular smooth muscle contraction	19/1378	134/8135	0.8351	0.9239	0.6074	MAPK3/MYL6B/PRKCB/PLA2G2D/PRKCH/ROCK1/PPP1R12A/PLA2G4C/ITPR2/NPR2/AGT/ADCY1/PRKCQ/CACNA1D/ADCY2/RAF1/KCNMB2/MYH10/CALML4	19
KEGG	hsa04726	Serotonergic synapse	16/1378	115/8135	0.8407	0.927	0.6095	PTGS1/SLC18A2/MAPK3/PRKCB/GABRB1/HTR2B/GNG3/GNG12/PLA2G4C/ITPR2/GNB2/KCNN2/CACNA1D/RAF1/KRAS/NRAS	16
KEGG	hsa05150	Staphylococcus aureus infection	13/1378	96/8135	0.8492	0.9322	0.613	HLA-DRB4/ITGAL/KRT10/CFD/CFI/KRT14/HLA-DOB/DEFA6/HLA-DQB1/MBL2/DEFA5/KRT33A/KRT24	13
KEGG	hsa04971	Gastric acid secretion	10/1378	76/8135	0.8511	0.9322	0.613	ATP1B1/KCNQ1/PRKCB/KCNJ2/ITPR2/ADCY1/CA2/ADCY2/CAMK2B/CALML4	10
KEGG	hsa05100	Bacterial invasion of epithelial cells	10/1378	77/8135	0.8621	0.9412	0.6189	ACTR3B/ARPC1A/ITGA5/ACTR3/PIK3CB/ARPC5L/CTTN/PIK3CD/ACTR2/PIK3CA	10
KEGG	hsa05032	Morphine addiction	12/1378	91/8135	0.8663	0.9427	0.6198	PRKCB/PDE1A/GABRB1/GNG3/GABRA4/GNG12/ARRB1/ADCY1/GNB2/ADCY2/GABBR1/GRK6	12
KEGG	hsa00670	One carbon pool by folate	2/1378	20/8135	0.8762	0.9504	0.6249	MTHFD2/TYMS	2
KEGG	hsa01250	Biosynthesis of nucleotide sugars	4/1378	37/8135	0.8941	0.9667	0.6356	MPI/PGM1/GMDS/PMM1	4
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	14/1378	109/8135	0.9028	0.9729	0.6397	RBM28/NXF3/UTP6/NHP2/CSNK2B/HEATR1/NMD3/NXF1/POP7/AK6/MDN1/WDR43/EIF6/IMP3	14
KEGG	hsa04976	Bile secretion	11/1378	89/8135	0.9077	0.9751	0.6411	ATP1B1/EPHX1/ABCC4/SLC27A5/RXRA/UGT2B17/ADCY1/CA2/ABCB1/KCNN2/ADCY2	11
KEGG	hsa04713	Circadian entrainment	12/1378	97/8135	0.915	0.9797	0.6442	MAPK3/PRKCB/GNG3/GNG12/GRIA2/ADCY1/GNB2/CACNA1D/ADCY2/CREB1/CAMK2B/CALML4	12
KEGG	hsa04721	Synaptic vesicle cycle	9/1378	78/8135	0.9296	0.9913	0.6518	SLC18A2/ATP6V0D1/AP2M1/TCIRG1/ATP6V0E2/VAMP2/SYT1/NAPA/SLC1A1	9
KEGG	hsa04977	Vitamin digestion and absorption	2/1378	24/8135	0.9317	0.9913	0.6518	ABCC1/LMBRD1	2
KEGG	hsa05206	MicroRNAs in cancer	43/1378	310/8135	0.9418	0.9985	0.6565	CDC25B/NOTCH1/MAPK3/PLCG2/PRKCB/DNMT1/SOS1/DDIT4/EZH2/ATM/EGFR/ITGA5/PIM1/NOTCH4/SOCS1/MAPK7/UBE2I/ERBB2/EFNA5/HNRNPK/ROCK1/FZD3/CD44/NFKB1/ZFPM2/ABCC1/PIK3CB/MYC/PDGFB/VEGFA/MCL1/ABCB1/HDAC1/BCL2L2/PIK3CD/RAF1/CCND2/CDKN1A/EP300/KRAS/HMGA2/NRAS/PIK3CA	43
KEGG	hsa03010	Ribosome	20/1378	158/8135	0.9445	0.9985	0.6565	RPS8/RPL12/MRPL24/MRPL11/RPS11/RPL10A/MRPL23/RPS5/RPL27A/MRPS17/RPL8/RPL19/MRPS11/MRPL17/MRPL20/MRPL18/MRPS14/RPL35A/MRPL4/RPLP0	20
KEGG	hsa04978	Mineral absorption	6/1378	60/8135	0.9547	1	0.6575	ATP1B1/CYBRD1/FTL/ATP2B2/ATP2B4/ATP2B1	6
KEGG	hsa05168	Herpes simplex virus 1 infection	70/1378	495/8135	0.9643	1	0.6575	NFKBIA/TAP1/SRPK1/HLA-C/STAT1/BIRC3/JAK2/HLA-DRB4/CCL5/ZNF611/TBK1/ZNF267/HLA-F/FAS/HLA-G/HLA-A/TRAF5/NXF3/BAD/ZNF721/ZNF160/ITGA5/TNFRSF14/TYK2/BIRC2/HLA-B/HLA-E/JAK1/IRF3/ZNF430/TAPBP/NXF1/ZNF226/POU2F1/NFKB1/IFNG/APAF1/DAXX/HCFC2/CHUK/PIK3CB/IL6/PML/IRAK4/ZNF552/HLA-DOB/ZNF93/SRSF4/HLA-DQB1/CASP9/ZNF415/SRSF8/TAP2/TRAF3/ZNF132/ZNF587/ZNF222/ZNF562/PIK3CD/IKBKG/ZNF667/TNFSF14/OAS2/ZNF613/MYD88/ZNF343/ZNF91/CFP/ZNF549/PIK3CA	70
KEGG	hsa00591	Linoleic acid metabolism	2/1378	29/8135	0.9684	1	0.6575	PLA2G2D/PLA2G4C	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/1378	29/8135	0.9684	1	0.6575	CSNK1E/NF2	2
KEGG	hsa04744	Phototransduction	2/1378	29/8135	0.9684	1	0.6575	GUCA1A/CALML4	2
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/1378	19/8135	0.9707	1	0.6575	GOT1	1
KEGG	hsa04974	Protein digestion and absorption	11/1378	103/8135	0.9727	1	0.6575	ATP1B1/CPA3/KCNQ1/SLC38A2/COL15A1/COL5A3/COL6A3/COL4A1/COL3A1/COL4A2/SLC1A1	11
KEGG	hsa05033	Nicotine addiction	3/1378	40/8135	0.9754	1	0.6575	GABRB1/GABRA4/GRIA2	3
KEGG	hsa00830	Retinol metabolism	6/1378	68/8135	0.9818	1	0.6575	PNPLA4/ALDH1A1/DHRS3/DHRS9/UGT2B17/ALDH1A3	6
KEGG	hsa04975	Fat digestion and absorption	3/1378	43/8135	0.984	1	0.6575	AGPAT1/PLA2G2D/ACAT1	3
KEGG	hsa04613	Neutrophil extracellular trap formation	22/1378	190/8135	0.9852	1	0.6575	MAPK3/PLCG2/SLC25A4/PRKCB/ITGAL/CASP4/ELANE/NFKB1/CR1/MAPK11/PIK3CB/RAC2/HMGB1/HDAC1/PIK3CD/GSDMD/RAF1/CTSG/VDAC3/TLR8/PIK3CA/NCF1	22
KEGG	hsa03015	mRNA surveillance pathway	9/1378	97/8135	0.9894	1	0.6575	NXF3/RNGTT/CPSF7/NXF1/PABPC3/TARDBP/NCBP2/DAZAP1/CSTF2	9
KEGG	hsa04950	Maturity onset diabetes of the young	1/1378	26/8135	0.992	1	0.6575	NR5A2	1
KEGG	hsa04742	Taste transduction	7/1378	86/8135	0.9943	1	0.6575	PDE1A/GABRA4/TAS2R3/PKD2L1/SCN9A/GABBR1/SCN3A	7
KEGG	hsa05034	Alcoholism	19/1378	187/8135	0.997	1	0.6575	SLC18A2/MAPK3/SLC29A1/SOS1/NTRK2/CREB3/GNG3/GNG12/GNB2/HDAC1/RAF1/CREB1/ATF2/KRAS/ATF4/BDNF/TH/CALML4/NRAS	19
KEGG	hsa05322	Systemic lupus erythematosus	12/1378	136/8135	0.9979	1	0.6575	C7/HLA-DRB4/CD28/CD40/ELANE/IFNG/TRIM21/HLA-DOB/HLA-DQB1/CTSG/ACTN1/CD40LG	12
KEGG	hsa04080	Neuroactive ligand-receptor interaction	36/1378	353/8135	0.9999	1	0.6575	ADORA3/TACR2/PTH1R/GABRB1/PENK/HTR2B/GABRA4/HRH3/GZMA/GRIA2/PTGER4/PTGFR/S1PR1/F2R/ADRB2/CHRNA3/AGT/TSPO/HCRT/GHSR/VIPR1/HCRTR2/NPY1R/P2RX4/CALCR/CHRNB1/SSTR5/NMB/LPAR2/TAC1/CTSG/GABBR1/GAL/CCKAR/GHR/GALR3	36
KEGG	hsa04740	Olfactory transduction	8/1378	440/8135	1	1	0.6575	PDE1A/OR7A17/ARRB1/OR10H1/OR1F1/CAMK2B/OR12D2/CALML4	8