ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05169	Epstein-Barr virus infection	68/1141	202/8135	6.525e-13	2.147e-10	1.511e-10	TRAF3/CD3D/RELB/PIK3R1/CD3E/TNFAIP3/TAP1/TAPBP/RUNX3/IRF9/CD247/HLA-F/HLA-A/STAT1/TAP2/MYD88/HLA-C/CCND2/OAS2/NFKB2/TLR2/BID/CD3G/OAS1/NFKBIE/HLA-G/ICAM1/IRF7/CD40/CXCL10/HLA-E/ITGAL/HLA-DRA/HLA-DPB1/PLCG2/HLA-B/BAK1/CCNA2/NFKBIA/PIK3CD/MAPK13/HLA-DMA/DDX58/NFKB1/CD19/ADRM1/HLA-DMB/PIK3CA/OAS3/SYK/CCND1/IKBKG/PIK3R3/BTK/AKT3/APAF1/IL6/ENTPD1/HLA-DPA1/RB1/LYN/TP53/USP7/CCNE2/IFNA1/TYK2/ISG15/CR2	68
KEGG	hsa05144	Malaria	25/1141	50/8135	1.373e-09	2.039e-07	1.435e-07	KLRB1/MYD88/TLR2/HBB/ITGB2/ICAM1/CD36/CD40/COMP/GYPC/THBS4/ITGAL/CXCL8/CR1/SELE/HGF/CD40LG/IFNG/PECAM1/TGFB3/IL6/IL18/CD81/CCL2/IL1B	25
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	38/1141	100/8135	1.859e-09	2.039e-07	1.435e-07	CCL5/CXCL13/IL2RG/CXCL9/CCR5/XCL1/CCR2/TNFRSF1B/CXCR4/IL2RB/CCL19/CCL13/CCR7/TNFSF10/ACKR3/CXCL1/TNFRSF14/CXCL10/CXCL8/CCL21/CCR1/CX3CR1/CCL18/CXCL3/IL6ST/CXCL11/CCL7/IL10RA/IL6/CXCL2/CCR8/CXCL5/CXCL6/IL18/CCL17/IL2RA/CCL2/CCL23	38
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	37/1141	97/8135	2.688e-09	2.211e-07	1.556e-07	WASF3/PIK3R1/PTPRC/RAC2/LAT/PRKCB/LIMK2/SPHK1/PLCG2/WAS/PLD1/ASAP2/DOCK1/PIK3CD/MARCKSL1/PLA2G4C/VASP/ARPC5L/VAV1/PIK3CA/PAK1/SYK/PIK3R3/AKT3/INPP5D/CFL1/GAB2/LYN/HCK/ARPC1A/WASF2/NCF1/ACTR3/FCGR3B/GSN/VAV3/ACTR2	37
KEGG	hsa04662	B cell receptor signaling pathway	33/1141	82/8135	3.984e-09	2.621e-07	1.845e-07	PIK3R1/LILRB2/RAC2/PPP3CA/RASGRP3/PRKCB/LILRA3/CD72/NFKBIE/MALT1/LILRB3/PTPN6/PLCG2/LILRB4/NFKBIA/PIK3CD/NFKB1/CD19/VAV1/PIK3CA/SYK/IKBKG/PIK3R3/BTK/AKT3/INPP5D/LYN/CD81/DAPP1/LILRA6/VAV3/CR2/LILRB1	33
KEGG	hsa05416	Viral myocarditis	27/1141	60/8135	5.784e-09	3.172e-07	2.233e-07	SGCB/PRF1/HLA-F/HLA-A/RAC2/HLA-C/SGCA/BID/ITGB2/LAMA2/HLA-G/ICAM1/CD40/HLA-E/DAG1/ITGAL/HLA-DRA/HLA-DPB1/HLA-B/CD40LG/SGCD/HLA-DMA/CD86/HLA-DMB/CCND1/CD80/HLA-DPA1	27
KEGG	hsa04064	NF-kappa B signaling pathway	37/1141	104/8135	2.426e-08	1.14e-06	8.027e-07	TRAF3/RELB/LCK/TNFAIP3/BIRC3/BCL2A1/TRAF1/PRKCQ/CCL19/MYD88/LAT/CCL13/NFKB2/PRKCB/LTB/ICAM1/MALT1/CXCL1/CD40/ZAP70/CXCL8/PLCG2/CCL21/NFKBIA/CD40LG/DDX58/NFKB1/CXCL3/SYK/PARP1/IKBKG/BTK/CXCL2/LYN/CFLAR/IL1R1/IL1B	37
KEGG	hsa04062	Chemokine signaling pathway	56/1141	192/8135	2.858e-08	1.175e-06	8.272e-07	CCL5/CXCL13/ITK/CXCL9/CCR5/XCL1/PIK3R1/CCR2/GNG12/RAC2/STAT1/CXCR4/GRK6/CCL19/CCL13/PARD3/CCR7/PRKCB/CXCL1/JAK2/CXCL10/FGR/CXCL8/PLCG2/CCL21/WAS/CCR1/CX3CR1/CXCR6/NFKBIA/PIK3CD/CCL18/NFKB1/DOCK2/VAV1/CXCL3/CXCL11/PIK3CA/CCL7/PAK1/IKBKG/PIK3R3/AKT3/CXCL2/CCR8/CXCL5/CXCL6/FOXO3/LYN/SHC2/HCK/NCF1/CCL17/CCL2/CCL23/VAV3	56
KEGG	hsa04659	Th17 cell differentiation	37/1141	108/8135	7.579e-08	2.557e-06	1.8e-06	CD3D/IL2RG/LCK/CD3E/IL27RA/IL21R/CD247/STAT1/PRKCQ/IL2RB/LAT/PPP3CA/IRF4/CD3G/IL4R/NFKBIE/JAK2/ZAP70/HLA-DRA/HLA-DPB1/TBX21/NFKBIA/MAPK13/HLA-DMA/NFKB1/HLA-DMB/SMAD3/IL6ST/IFNG/HSP90AB1/IKBKG/IL6/HLA-DPA1/IL2RA/TYK2/IL1R1/IL1B	37
KEGG	hsa04514	Cell adhesion molecules	46/1141	149/8135	7.771e-08	2.557e-06	1.8e-06	PTPRC/CTLA4/CD2/HLA-F/ITGB7/CD8A/HLA-A/ITGA4/HLA-C/MPZL1/JAM3/ITGB2/HLA-G/ICAM1/SELL/CD40/HLA-E/ITGAL/HLA-DRA/SELE/HLA-DPB1/HLA-B/NEO1/CD226/GLG1/PDCD1LG2/NLGN1/PTPRF/CD40LG/CDH2/CADM1/HLA-DMA/ICAM3/CD86/VCAN/CD6/HLA-DMB/ICOS/PECAM1/CD80/ICOSLG/SELPLG/HLA-DPA1/ITGAV/CLDN14/CDH5	46
KEGG	hsa04060	Cytokine-cytokine receptor interaction	75/1141	295/8135	8.965e-08	2.681e-06	1.887e-06	CCL5/CXCL13/CSF2RB/IL2RG/CXCL9/CCR5/XCL1/CCR2/GDF5/BMP4/IL27RA/TNFRSF11B/IL15RA/IL21R/IL32/TNFRSF1B/CXCR4/IL2RB/IL3RA/CCL19/IL15/IL7R/IL11RA/INHBA/CCL13/CCR7/TNFSF10/LTB/IL4R/ACKR3/BMPR1A/CXCL1/CD40/TNFRSF14/CXCL10/CXCL8/CCL21/GHR/CCR1/IL13RA2/CX3CR1/CXCR6/CD27/CD40LG/CCL18/CXCL3/LEP/IL6ST/IL16/IFNG/CXCL11/PRL/CCL7/ACVR1/IL10RA/CTF1/TGFB3/TNFRSF4/IL6/CXCL2/CCR8/LIFR/CXCL5/CXCL6/IL18/IL1RN/CCL17/TNFRSF9/IL2RA/CCL2/CCL23/IFNA1/IL1R1/IL1B/TNFRSF17	75
KEGG	hsa05164	Influenza A	50/1141	171/8135	1.457e-07	3.994e-06	2.811e-06	CCL5/TRAF3/PIK3R1/IRF9/STAT1/MYD88/OAS2/PRKCB/BID/TNFSF10/MX2/OAS1/ICAM1/IRF7/JAK2/IFIH1/CXCL10/CREBBP/HLA-DRA/CXCL8/HLA-DPB1/BAK1/NFKBIA/PIK3CD/HLA-DMA/DDX58/NFKB1/CASP1/HLA-DMB/SLC25A4/IFNG/PIK3CA/ADAR/OAS3/IKBKG/PIK3R3/AKT3/APAF1/IL6/HLA-DPA1/KPNA2/IL18/SLC25A5/MX1/CCL2/IFNA1/TYK2/IL1B/PML/NLRP3	50
KEGG	hsa05162	Measles	43/1141	139/8135	1.935e-07	4.896e-06	3.446e-06	TRAF3/CD3D/IL2RG/PIK3R1/CD3E/TNFAIP3/SLAMF1/IRF9/STAT1/IL2RB/MYD88/CCND2/OAS2/TLR2/BID/MX2/CD3G/OAS1/IRF7/IFIH1/HSPA6/BAK1/NFKBIA/PIK3CD/DDX58/NFKB1/PIK3CA/ADAR/OAS3/CCND1/IKBKG/PIK3R3/AKT3/APAF1/IL6/HSPA1L/MX1/IL2RA/TP53/CCNE2/IFNA1/TYK2/IL1B	43
KEGG	hsa04640	Hematopoietic cell lineage	34/1141	99/8135	2.385e-07	5.605e-06	3.945e-06	CD3D/KITLG/CD3E/CD2/CD7/CD8A/IL3RA/IL7R/ITGA4/IL11RA/CD3G/IL4R/CD5/CD36/TFRC/HLA-DRA/CR1/HLA-DPB1/HLA-DMA/MS4A1/CD19/HLA-DMB/CD9/FLT3/CD37/IL6/ANPEP/CD38/HLA-DPA1/GP1BA/IL2RA/IL1R1/IL1B/CR2	34
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	54/1141	194/8135	2.769e-07	5.752e-06	4.049e-06	TRAF3/CCR5/PIK3R1/IRF9/HLA-F/GNG12/HLA-A/STAT1/HLA-C/PPP3CA/BID/HLA-G/ICAM1/IRF7/CXCL1/JAK2/MICB/HLA-E/FGF2/CREBBP/CXCL8/PLCG2/HLA-B/TCF7/BAK1/CCR1/TCF7L2/NFKBIA/PIK3CD/MAPK13/NFKB1/CD86/LEF1/CXCL3/IL6ST/TCF7L1/PIK3CA/ATG3/SYK/CCND1/IKBKG/PIK3R3/AKT3/MAPKAPK2/IL6/CXCL2/CCR8/RB1/LYN/CLEC2B/HCK/TP53/IFNA1/TYK2	54
KEGG	hsa04660	T cell receptor signaling pathway	35/1141	104/8135	2.797e-07	5.752e-06	4.049e-06	ITK/CD3D/LCK/PIK3R1/CD3E/PTPRC/CTLA4/RASGRP1/CD247/CD8A/PRKCQ/LAT/PPP3CA/LCP2/CD3G/NFKBIE/MALT1/MAP3K8/PTPN6/ZAP70/NFKBIA/CD40LG/PIK3CD/MAPK13/NFKB1/ICOS/VAV1/IFNG/PIK3CA/PAK1/TEC/IKBKG/PIK3R3/AKT3/VAV3	35
KEGG	hsa04380	Osteoclast differentiation	40/1141	128/8135	3.827e-07	7.406e-06	5.213e-06	RELB/LCK/PIK3R1/TNFRSF11B/IRF9/LILRB2/STAT1/PPP3CA/SIRPG/NFKB2/LCP2/LILRA3/LILRB3/SOCS1/PLCG2/LILRB4/NCF4/NFKBIA/PIK3CD/MAPK13/NFKB1/IFNG/PIK3CA/SYK/TEC/FOSL1/IKBKG/SPI1/PIK3R3/BTK/AKT3/CYBA/GAB2/NCF1/LILRA6/FCGR3B/TYK2/IL1R1/IL1B/LILRB1	40
KEGG	hsa04630	JAK-STAT signaling pathway	47/1141	162/8135	4.437e-07	8.11e-06	5.709e-06	CSF2RB/IL2RG/PIK3R1/IL27RA/IRF9/IL15RA/IL21R/STAT1/IL2RB/IL3RA/IL15/IL7R/IL11RA/PIM1/CCND2/PTPN2/IL4R/JAK2/SOCS1/CISH/EGFR/STAT4/PTPN6/CREBBP/FHL1/GHR/IL13RA2/SOCS2/PIK3CD/PTPN11/LEP/IL6ST/IFNG/SOCS6/PIK3CA/PRL/CCND1/IL10RA/CTF1/PIK3R3/AKT3/IL6/LIFR/GFAP/IL2RA/IFNA1/TYK2	47
KEGG	hsa05323	Rheumatoid arthritis	32/1141	93/8135	5.121e-07	8.868e-06	6.242e-06	CCL5/CTLA4/IL15/MMP1/TLR2/ANGPT1/TCIRG1/ITGB2/LTB/ICAM1/CXCL1/CTSL/ITGAL/HLA-DRA/CXCL8/HLA-DPB1/HLA-DMA/CD86/HLA-DMB/CXCL3/IFNG/CD80/TGFB3/IL6/CXCL2/HLA-DPA1/CXCL5/CXCL6/IL18/CCL2/ATP6V1B2/IL1B	32
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	40/1141	131/8135	7.528e-07	1.2e-05	8.445e-06	LCK/PIK3R1/PRF1/CD48/CD247/HLA-A/RAC2/HLA-C/LAT/PPP3CA/GZMB/PRKCB/BID/LCP2/TNFSF10/ITGB2/HLA-G/ICAM1/MICB/HLA-E/PTPN6/ITGAL/ZAP70/SH2D1A/PLCG2/HLA-B/KLRD1/PIK3CD/PTPN11/VAV1/IFNG/PIK3CA/PAK1/SYK/PIK3R3/SHC2/KIR2DS1/FCGR3B/IFNA1/VAV3	40
KEGG	hsa05330	Allograft rejection	18/1141	38/8135	8.023e-07	1.2e-05	8.445e-06	PRF1/HLA-F/HLA-A/HLA-C/GZMB/HLA-G/CD40/HLA-E/HLA-DRA/HLA-DPB1/HLA-B/CD40LG/HLA-DMA/CD86/HLA-DMB/IFNG/CD80/HLA-DPA1	18
KEGG	hsa05340	Primary immunodeficiency	18/1141	38/8135	8.023e-07	1.2e-05	8.445e-06	CD3D/IL2RG/LCK/CD3E/PTPRC/TAP1/CD8A/IL7R/TAP2/RFX5/CD40/ADA/ZAP70/CD40LG/CD19/ICOS/IKBKG/BTK	18
KEGG	hsa05332	Graft-versus-host disease	19/1141	42/8135	9.64e-07	1.379e-05	9.706e-06	PRF1/HLA-F/HLA-A/HLA-C/GZMB/HLA-G/HLA-E/HLA-DRA/HLA-DPB1/HLA-B/KLRD1/HLA-DMA/CD86/HLA-DMB/IFNG/CD80/IL6/HLA-DPA1/IL1B	19
KEGG	hsa04658	Th1 and Th2 cell differentiation	31/1141	92/8135	1.293e-06	1.773e-05	1.248e-05	CD3D/IL2RG/LCK/CD3E/RUNX3/CD247/STAT1/PRKCQ/IL2RB/LAT/PPP3CA/CD3G/IL4R/NFKBIE/JAK2/STAT4/ZAP70/HLA-DRA/HLA-DPB1/TBX21/NFKBIA/MAPK13/HLA-DMA/NFKB1/HLA-DMB/NOTCH1/IFNG/IKBKG/HLA-DPA1/IL2RA/TYK2	31
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	30/1141	89/8135	1.897e-06	2.496e-05	1.757e-05	CD3D/LCK/PIK3R1/CD3E/EML4/RASGRP1/CD247/STAT1/PRKCQ/BATF/MYD88/LAT/PPP3CA/TLR2/CD3G/NFKBIE/JAK2/EGFR/PTPN6/ZAP70/NFKBIA/PIK3CD/MAPK13/NFKB1/PTPN11/IFNG/PIK3CA/IKBKG/PIK3R3/AKT3	30
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	57/1141	222/8135	2.315e-06	2.929e-05	2.062e-05	CD3D/IL2RG/RELB/CDKN2C/LCK/PIK3R1/CD3E/IL15RA/HLA-F/HLA-A/IL2RB/IL15/PTTG1/HLA-C/CCND2/PPP3CA/NFKB2/CCNB2/ITGB2/CD3G/HLA-G/ICAM1/MAD2L1/CD40/HLA-E/CREBBP/ITGAL/HLA-DRA/HLA-DPB1/HLA-B/CREB3L2/CCNA2/BUB1B/NFKBIA/PIK3CD/HLA-DMA/NFKB1/HLA-DMB/SMAD3/SLC25A4/PIK3CA/CCND1/FOSL1/IKBKG/SPI1/TGFB3/PIK3R3/AKT3/IL6/HLA-DPA1/RB1/CDC20/SLC25A5/IL2RA/TP53/CCNE2/IL1R1	57
KEGG	hsa05132	Salmonella infection	62/1141	249/8135	2.544e-06	3.1e-05	2.182e-05	WASF3/PTPRC/BIRC3/DYNC2LI1/CYTH1/MYD88/SKP1/TLR2/TNFSF10/PFN2/DYNC1LI2/ARHGEF26/WASL/TUBA4A/RIPK2/TUBB2B/CXCL8/TCF7/BAK1/RHOH/TCF7L2/TUBB4A/NFKBIA/TLR5/NCKAP1L/PIK3CD/DYNC1I1/MAPK13/RRAS/VPS16/NFKB1/CASP1/LEF1/CYFIP2/ARPC5L/CASP5/RHOG/CYTH4/TCF7L1/AHNAK2/PIK3CA/MYL5/HSP90AB1/PAK1/DCTN6/IKBKG/AKT3/IL6/MYL9/IL18/NOD1/ARPC1A/DYNLRB1/FYCO1/ACTR3/PFN1/CASP4/TLR6/IL1B/ACTR2/NLRP3/TXN2	62
KEGG	hsa04612	Antigen processing and presentation	27/1141	78/8135	3.463e-06	4.069e-05	2.864e-05	TAP1/TAPBP/HLA-F/CD8A/HLA-A/TAP2/HLA-C/RFX5/CD74/HLA-G/CTSL/PSME1/HLA-E/HSPA6/HLA-DRA/HLA-DPB1/HLA-B/KLRD1/HLA-DMA/CTSB/HLA-DMB/IFNG/NFYA/HSP90AB1/HLA-DPA1/HSPA1L/KIR2DS1	27
KEGG	hsa04668	TNF signaling pathway	34/1141	112/8135	5.816e-06	6.599e-05	4.645e-05	CCL5/TRAF3/PIK3R1/TNFAIP3/IRF1/BIRC3/TNFRSF1B/TRAF1/IL15/ICAM1/NOD2/CXCL1/MAP3K8/CXCL10/CASP10/SELE/CREB3L2/NFKBIA/PIK3CD/MAPK13/RPS6KA4/NFKB1/CXCL3/PIK3CA/IKBKG/PIK3R3/AKT3/IL6/CXCL2/CXCL5/CXCL6/CFLAR/CCL2/IL1B	34
KEGG	hsa05221	Acute myeloid leukemia	24/1141	67/8135	6.102e-06	6.692e-05	4.71e-05	PIK3R1/BCL2A1/ZBTB16/PIM1/RUNX1T1/TCF7/CCNA2/TCF7L2/PER2/PIK3CD/NFKB1/LEF1/TCF7L1/PIK3CA/FLT3/CCND1/IKBKG/SPI1/PIK3R3/AKT3/DUSP6/CEBPA/PIM2/PML	24
KEGG	hsa04940	Type I diabetes mellitus	18/1141	43/8135	7.245e-06	7.689e-05	5.413e-05	PRF1/HLA-F/HLA-A/HLA-C/GZMB/HLA-G/HLA-E/HLA-DRA/HLA-DPB1/HLA-B/HLA-DMA/CD86/CPE/HLA-DMB/IFNG/CD80/HLA-DPA1/IL1B	18
KEGG	hsa04810	Regulation of actin cytoskeleton	53/1141	218/8135	2.78e-05	0.0002794	0.0001967	PIK3R1/GNG12/ITGB7/RAC2/MYH10/FGF18/CXCR4/ITGA4/LPAR1/FGF7/PFN2/ITGB2/LIMK2/PDGFD/WASL/PIP4K2B/EGFR/FGF2/ITGAL/ENAH/DOCK1/NCKAP1L/PIK3CD/RRAS/ARHGEF12/CYFIP2/ARPC5L/VAV1/ITGA10/PPP1CA/PIK3CA/MYL5/PAK1/FGF9/ITGAX/PIK3R3/SSH3/CFL1/MYH11/PIP4K2A/MYL9/ARPC1A/MYLK/WASF2/ABI2/ACTR3/PFN1/ITGAV/IQGAP2/GSN/ITGAE/VAV3/ACTR2	53
KEGG	hsa05140	Leishmaniasis	25/1141	77/8135	2.803e-05	0.0002794	0.0001967	STAT1/ITGA4/MYD88/PRKCB/TLR2/ITGB2/JAK2/PTPN6/HLA-DRA/CR1/HLA-DPB1/NCF4/NFKBIA/MAPK13/HLA-DMA/MARCKSL1/NFKB1/HLA-DMB/IFNG/TGFB3/HLA-DPA1/CYBA/NCF1/FCGR3B/IL1B	25
KEGG	hsa05202	Transcriptional misregulation in cancer	48/1141	193/8135	3.547e-05	0.000337	0.0002372	CDKN2C/BCL11B/IGF1/BIRC3/ITGB7/BCL2A1/TRAF1/HOXA10/IL2RB/FLI1/ZBTB16/PBX3/CCND2/RUNX1T1/GZMB/MEIS1/SIX1/CD40/KMT2A/ETV5/CXCL8/CCNT1/BAK1/SP1/CCNA2/PER2/PLAT/PBX1/NFKB1/CD86/FOXO1/ETV6/CDK14/PAX5/FLT3/MLF1/SPI1/IL6/DUSP6/DDIT3/BMP2K/CEBPA/FUT8/HOXA11/SS18/TP53/SSX1/PML	48
KEGG	hsa04210	Apoptosis	37/1141	136/8135	3.585e-05	0.000337	0.0002372	CSF2RB/PIK3R1/PRF1/BIRC3/BCL2A1/TRAF1/IL3RA/CTSF/GZMB/LMNB1/BID/TNFSF10/CTSC/TUBA4A/CTSL/CTSW/CASP10/BAK1/CTSO/NFKBIA/PIK3CD/NFKB1/PMAIP1/CTSB/PTPN13/PIK3CA/PARP4/PARP1/IKBKG/PIK3R3/AKT3/APAF1/DDIT3/LMNA/CFLAR/TP53/CTSH	37
KEGG	hsa05135	Yersinia infection	37/1141	137/8135	4.263e-05	0.0003896	0.0002742	LCK/PIK3R1/CD8A/RAC2/ITGA4/MYD88/LAT/LCP2/WASL/RPS6KA1/ZAP70/CXCL8/WAS/NFKBIA/DOCK1/PIK3CD/MAPK13/NFKB1/CASP1/ARHGEF12/ARPC5L/VAV1/RHOG/PIK3CA/IKBKG/PIK3R3/AKT3/IL6/IL18/ARPC1A/WASF2/ACTR3/CCL2/VAV3/IL1B/ACTR2/NLRP3	37
KEGG	hsa04621	NOD-like receptor signaling pathway	46/1141	184/8135	4.473e-05	0.0003977	0.0002799	CCL5/TRAF3/AIM2/TNFAIP3/GBP1/IRF9/BIRC3/GABARAPL1/GBP2/STAT1/MYD88/OAS2/ANTXR1/OAS1/NOD2/IRF7/CXCL1/RIPK2/GABARAPL2/CXCL8/TRPV2/NFKBIA/NEK7/MAPK13/NFKB1/CASP1/CTSB/CXCL3/CASP5/HSP90AB1/OAS3/TRIP6/IKBKG/IL6/CXCL2/CYBA/IL18/NOD1/PANX1/CASP4/CCL2/IFNA1/TYK2/IL1B/NLRP3/TXN2	46
KEGG	hsa05134	Legionellosis	20/1141	57/8135	5.068e-05	0.0004388	0.0003089	MYD88/NFKB2/TLR2/ITGB2/CXCL1/HSPA6/CXCL8/CR1/NFKBIA/TLR5/NFKB1/CASP1/VCP/CXCL3/APAF1/IL6/CXCL2/IL18/HSPA1L/IL1B	20
KEGG	hsa05320	Autoimmune thyroid disease	19/1141	53/8135	5.546e-05	0.0004679	0.0003293	CTLA4/PRF1/HLA-F/HLA-A/HLA-C/GZMB/HLA-G/CD40/HLA-E/HLA-DRA/HLA-DPB1/HLA-B/CD40LG/HLA-DMA/CD86/HLA-DMB/CD80/HLA-DPA1/IFNA1	19
KEGG	hsa04625	C-type lectin receptor signaling pathway	30/1141	104/8135	5.965e-05	0.00048	0.0003379	RELB/PIK3R1/IRF1/IRF9/STAT1/PPP3CA/NFKB2/MALT1/CLEC7A/PLCG2/CLEC4E/NFKBIA/PIK3CD/MAPK13/RRAS/NFKB1/CASP1/ARHGEF12/PTPN11/PIK3CA/PAK1/SYK/IKBKG/PIK3R3/AKT3/MAPKAPK2/IL6/CCL17/IL1B/NLRP3	30
KEGG	hsa04672	Intestinal immune network for IgA production	18/1141	49/8135	5.982e-05	0.00048	0.0003379	IL15RA/ITGB7/CXCR4/IL15/ITGA4/CD40/HLA-DRA/HLA-DPB1/CD40LG/HLA-DMA/CD86/HLA-DMB/ICOS/CD80/ICOSLG/IL6/HLA-DPA1/TNFRSF17	18
KEGG	hsa05321	Inflammatory bowel disease	21/1141	65/8135	0.0001307	0.001024	0.0007207	IL2RG/IL21R/STAT1/TLR2/IL4R/NOD2/STAT4/HLA-DRA/HLA-DPB1/TBX21/TLR5/HLA-DMA/NFKB1/HLA-DMB/SMAD3/IFNG/TGFB3/IL6/HLA-DPA1/IL18/IL1B	21
KEGG	hsa04620	Toll-like receptor signaling pathway	29/1141	104/8135	0.0001527	0.001168	0.0008222	CCL5/TRAF3/CXCL9/PIK3R1/TLR8/STAT1/MYD88/TLR2/IRF7/CD40/MAP3K8/CXCL10/CXCL8/NFKBIA/TLR5/PIK3CD/MAPK13/NFKB1/CD86/CXCL11/PIK3CA/CD80/IKBKG/PIK3R3/AKT3/IL6/IFNA1/TLR6/IL1B	29
KEGG	hsa04145	Phagosome	38/1141	152/8135	0.000201	0.001503	0.001058	TAP1/CORO1A/HLA-F/HLA-A/TAP2/HLA-C/TLR2/TCIRG1/ITGB2/HLA-G/DYNC1LI2/CD36/COMP/TUBA4A/CTSL/TFRC/TUBB2B/HLA-E/THBS4/CLEC7A/HLA-DRA/HLA-DPB1/MRC2/HLA-B/TUBB4A/NCF4/DYNC1I1/HLA-DMA/HLA-DMB/COLEC12/STX18/HLA-DPA1/CYBA/NCF1/ITGAV/ATP6V1B2/FCGR3B/TLR6	38
KEGG	hsa05152	Tuberculosis	43/1141	180/8135	0.0002359	0.001724	0.001214	CORO1A/STAT1/MYD88/PPP3CA/RFX5/TLR2/CD74/BID/TCIRG1/ITGB2/NOD2/MALT1/JAK2/RIPK2/CREBBP/SPHK1/CASP10/CLEC7A/HLA-DRA/CR1/HLA-DPB1/MRC2/CLEC4E/MAPK13/HLA-DMA/NFKB1/ARHGEF12/HLA-DMB/IFNG/NFYA/SYK/IL10RA/ITGAX/TGFB3/AKT3/APAF1/IL6/HLA-DPA1/IL18/FCGR3B/IFNA1/TLR6/IL1B	43
KEGG	hsa05215	Prostate cancer	27/1141	97/8135	0.000263	0.001881	0.001324	PIK3R1/IGF1/AR/PDGFD/EGFR/CREBBP/ETV5/ERBB2/CREB3L2/TCF7/TCF7L2/NFKBIA/PLAT/PIK3CD/NFKB1/LEF1/FOXO1/TCF7L1/PIK3CA/HSP90AB1/CCND1/IKBKG/PIK3R3/AKT3/RB1/TP53/CCNE2	27
KEGG	hsa05417	Lipid and atherosclerosis	49/1141	215/8135	0.0002995	0.002052	0.001445	CCL5/TRAF3/PIK3R1/MYD88/MMP1/PPP3CA/ABCG1/TLR2/BID/TNFSF10/ICAM1/IRF7/CXCL1/JAK2/CD36/CD40/HSPA6/CXCL8/SELE/NCF4/NFKBIA/CD40LG/PIK3CD/MAPK13/NFKB1/CASP1/VAV1/CXCL3/PIK3CA/HSP90AB1/IKBKG/PIK3R3/AKT3/APAF1/IL6/CXCL2/DDIT3/CYBA/IL18/LYN/HSPA1L/NCF1/TP53/CCL2/IFNA1/TLR6/VAV3/IL1B/NLRP3	49
KEGG	hsa05418	Fluid shear stress and atherosclerosis	35/1141	139/8135	0.0003053	0.002052	0.001445	PIK3R1/BMP4/NQO1/RAC2/GSTM5/GSTM3/GSTA4/ICAM1/BMPR1A/CTSL/SELE/PLAT/PIK3CD/MAPK13/NFKB1/IFNG/PECAM1/PIK3CA/HSP90AB1/ACVR1/IKBKG/PIK3R3/AKT3/CYBA/KDR/GSTO1/NCF1/GSTM2/ITGAV/TP53/CCL2/IL1R1/IL1B/CDH5/TXN2	35
KEGG	hsa05171	Coronavirus disease - COVID-19	52/1141	232/8135	0.0003057	0.002052	0.001445	TRAF3/PIK3R1/IRF9/TLR8/STAT1/MYD88/MMP1/OAS2/PRKCB/TLR2/MX2/OAS1/RPL31/IFIH1/CXCL10/EGFR/HBEGF/RPL24/CXCL8/PLCG2/NFKBIA/PIK3CD/CFD/MAPK13/DDX58/NFKB1/CASP1/IL6ST/AGTR1/RPS4X/PIK3CA/C7/ADAR/RPL12/OAS3/SYK/RSL24D1/IKBKG/PIK3R3/IL6/CFB/RPL15/MX1/RPL10A/CCL2/IFNA1/TYK2/ISG15/IL1B/RPS14/C6/NLRP3	52
KEGG	hsa04670	Leukocyte transendothelial migration	30/1141	114/8135	0.0003597	0.002367	0.001666	ITK/PIK3R1/RAC2/CXCR4/SIPA1/ITGA4/PRKCB/JAM3/ITGB2/ICAM1/ITGAL/PLCG2/TXK/RHOH/NCF4/PIK3CD/MAPK13/VASP/PTPN11/VAV1/PECAM1/PIK3CA/MYL5/PIK3R3/MYL9/CYBA/NCF1/CLDN14/VAV3/CDH5	30
KEGG	hsa05225	Hepatocellular carcinoma	40/1141	168/8135	0.0004132	0.002618	0.001843	PIK3R1/LRP6/WNT5B/NQO1/GSTM5/PRKCB/GSTM3/GSTA4/EGFR/PLCG2/SMARCD3/TCF7/BAK1/HGF/TCF7L2/LRP5/PIK3CD/FZD4/LEF1/SMAD3/SMARCC2/FZD7/SMARCA2/TCF7L1/PIK3CA/SMARCD1/CCND1/TGFB3/PIK3R3/AKT3/FZD6/PHF10/RB1/SHC2/DVL1/GSTO1/GSTM2/FZD2/TP53/FRAT1	40
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/1141	70/8135	0.0004138	0.002618	0.001843	CCL5/CSK/JAM3/TCIRG1/CXCL1/EGFR/HBEGF/CXCL8/PLCG2/NFKBIA/MAPK13/NFKB1/PTPN11/CXCL3/PAK1/IKBKG/CXCL2/ADAM10/LYN/NOD1/ATP6V1B2	21
KEGG	hsa04068	FoxO signaling pathway	33/1141	131/8135	0.000445	0.002762	0.001944	PIK3R1/IGF1/GABARAPL1/IL7R/CCND2/CCNB2/TNFSF10/PLK1/EGFR/GABARAPL2/CREBBP/PCK1/PIK3CD/MAPK13/FOXO1/SMAD3/PLK2/CCNB1/PIK3CA/CCND1/TGFB3/PIK3R3/AKT3/IL6/NLK/FOXO3/CAT/S1PR1/PRMT1/IRS4/USP7/PRKAB1/S1PR4	33
KEGG	hsa04110	Cell cycle	32/1141	126/8135	0.0004627	0.002819	0.001984	CDKN2C/TFDP2/CDKN1C/PTTG1/CCND2/BUB1/SKP1/CCNB2/MAD2L1/PLK1/CDC14B/CDC45/CREBBP/CDC25B/CDK1/CCNA2/STAG2/BUB1B/MCM5/SMAD3/CDC7/MCM2/CCNB1/CCND1/DBF4/TGFB3/TTK/RB1/CDC20/MCM4/TP53/CCNE2	32
KEGG	hsa05142	Chagas disease	27/1141	102/8135	0.0006299	0.003768	0.002652	CCL5/CD3D/PIK3R1/CD3E/CD247/GNAL/MYD88/PPP2CA/TLR2/CD3G/CXCL8/NFKBIA/PIK3CD/MAPK13/PPP2CB/NFKB1/IFNG/PIK3CA/IKBKG/TGFB3/PIK3R3/AKT3/IL6/CFLAR/CCL2/TLR6/IL1B	27
KEGG	hsa04218	Cellular senescence	37/1141	156/8135	0.0007242	0.004255	0.002995	PIK3R1/HLA-F/HLA-A/HLA-C/CCND2/PPP3CA/CCNB2/HLA-G/HLA-E/CXCL8/HLA-B/CDK1/CCNA2/PIK3CD/MAPK13/RRAS/NFKB1/FOXO1/SMAD3/SLC25A4/ZFP36L1/CCNB1/PPP1CA/PIK3CA/CCND1/TGFB3/PIK3R3/AKT3/MAPKAPK2/IL6/FOXO3/RB1/SLC25A5/HIPK2/ZFP36L2/TP53/CCNE2	37
KEGG	hsa04664	Fc epsilon RI signaling pathway	20/1141	68/8135	0.0007466	0.004309	0.003033	PIK3R1/RAC2/LAT/MS4A2/LCP2/PLCG2/PIK3CD/MAPK13/PLA2G4C/VAV1/PIK3CA/SYK/PIK3R3/BTK/AKT3/INPP5D/GAB2/LYN/VAV3/ALOX5	20
KEGG	hsa05224	Breast cancer	35/1141	147/8135	0.0009256	0.005251	0.003696	PIK3R1/LRP6/IGF1/WNT5B/FGF18/NFKB2/FGF7/EGFR/FGF2/ERBB2/TCF7/BAK1/SP1/TCF7L2/LRP5/PIK3CD/FZD4/LEF1/FZD7/NOTCH1/TCF7L1/PIK3CA/HEY2/CCND1/FGF9/PIK3R3/AKT3/FZD6/RB1/HEY1/SHC2/DVL1/FZD2/TP53/FRAT1	35
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/1141	100/8135	0.001052	0.005869	0.004131	PIK3R1/PLCE1/STAT1/PIM1/PRKCB/ICAM1/JAK2/CXCL8/SELE/PLCG2/NOX4/PIK3CD/MAPK13/NFKB1/FOXO1/SMAD3/AGTR1/PIK3CA/CCND1/TGFB3/PIK3R3/AKT3/IL6/VEGFB/CCL2/IL1B	26
KEGG	hsa04917	Prolactin signaling pathway	20/1141	70/8135	0.001116	0.00612	0.004308	PIK3R1/IRF1/GALT/STAT1/CCND2/JAK2/SOCS1/CISH/SOCS2/PIK3CD/MAPK13/NFKB1/SOCS6/PIK3CA/PRL/CCND1/PIK3R3/AKT3/FOXO3/SHC2	20
KEGG	hsa05170	Human immunodeficiency virus 1 infection	46/1141	212/8135	0.001374	0.007409	0.005215	CD3D/CCR5/PIK3R1/CD3E/AP1G2/TAP1/TAPBP/CD247/HLA-F/GNG12/TNFRSF1B/HLA-A/RAC2/CXCR4/TAP2/MYD88/HLA-C/PPP3CA/PRKCB/SKP1/TLR2/BID/CCNB2/APOBEC3G/CD3G/LIMK2/HLA-G/APOBEC3B/HLA-E/PLCG2/HLA-B/CDK1/BAK1/NFKBIA/PIK3CD/MAPK13/NFKB1/CCNB1/PIK3CA/PAK1/IKBKG/PIK3R3/AKT3/CFL1/CUL4B/IFNA1	46
KEGG	hsa00071	Fatty acid degradation	14/1141	43/8135	0.001555	0.00825	0.005807	ALDH7A1/ALDH3A2/ACADVL/ADH1C/ACAT1/ADH1B/ECI2/ECI1/ADH5/ACADL/HADH/ECHS1/ACSL5/HADHA	14
KEGG	hsa05160	Hepatitis C	36/1141	157/8135	0.001619	0.008452	0.005949	TRAF3/PIK3R1/IRF9/STAT1/PPP2CA/OAS2/BID/MX2/OAS1/IRF7/CXCL10/EGFR/BAK1/EIF3E/NFKBIA/PIK3CD/PPP2CB/DDX58/NFKB1/IFNG/PIK3CA/OAS3/CCND1/IKBKG/PIK3R3/AKT3/APAF1/NR1H3/RB1/CD81/MX1/CFLAR/TP53/IFNA1/TYK2/CLDN14	36
KEGG	hsa01524	Platinum drug resistance	20/1141	73/8135	0.001958	0.01007	0.007085	PIK3R1/BIRC3/GSTM5/GSTM3/BID/GSTA4/ERBB2/BAK1/PIK3CD/REV3L/TOP2A/PMAIP1/PIK3CA/PIK3R3/AKT3/APAF1/GSTO1/ERCC1/GSTM2/TP53	20
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	47/1141	223/8135	0.002297	0.01158	0.008149	PIK3R1/NQO1/NDUFC1/EPHX1/NDUFA4L2/GSTM5/AKR1C3/GSTM3/GSTA4/NDUFS2/COX7A1/SLC26A2/PRKD2/NDUFS4/EGFR/AKR1C1/HGF/PLD1/NFKBIA/NOX4/PIK3CD/NDUFA13/SOD1/MAPK13/NFKB1/PTPN11/SLC25A4/ARNT/PIK3CA/IKBKG/PIK3R3/AKT3/NDUFA9/FOXO3/CYBA/PRKD1/SLC25A5/SDHA/GSTO1/NDUFB6/CAT/NCF1/GSTM2/EPHX3/NDUFA4/EPHX2/COX7A2	47
KEGG	hsa04370	VEGF signaling pathway	17/1141	59/8135	0.002323	0.01158	0.008149	PIK3R1/RAC2/PPP3CA/PRKCB/SH2D2A/SPHK1/PLCG2/PIK3CD/MAPK13/PLA2G4C/PIK3CA/HSPB1/PIK3R3/AKT3/MAPKAPK2/KDR/SHC2	17
KEGG	hsa05145	Toxoplasmosis	27/1141	112/8135	0.002817	0.01383	0.009737	CCR5/BIRC3/STAT1/MYD88/TLR2/LAMA2/JAK2/CD40/SOCS1/HSPA6/HLA-DRA/HLA-DPB1/NFKBIA/CD40LG/MAPK13/HLA-DMA/NFKB1/HLA-DMB/IFNG/IL10RA/IKBKG/TGFB3/AKT3/HLA-DPA1/HSPA1L/TYK2/ALOX5	27
KEGG	hsa05130	Pathogenic Escherichia coli infection	42/1141	197/8135	0.00307	0.01485	0.01045	WASF3/MYH10/CYTH1/MYD88/LPAR1/TNFSF10/HCLS1/MYO1F/WASL/TUBA4A/TUBB2B/PTPN6/CXCL8/BAK1/TUBB4A/NFKBIA/TLR5/NCKAP1L/MAPK13/NFKB1/CASP1/ARHGEF12/CYFIP2/ARPC5L/PTPN11/CYTH4/PAK1/MYO1C/IKBKG/CTTN/IL6/MYH11/IL18/ARPC1A/WASF2/ACTR3/CASP4/IL1R1/CLDN14/IL1B/ACTR2/NLRP3	42
KEGG	hsa05212	Pancreatic cancer	20/1141	76/8135	0.003284	0.01559	0.01097	PIK3R1/RAC2/STAT1/RALGDS/EGFR/ERBB2/BAK1/PLD1/PIK3CD/NFKB1/SMAD3/PIK3CA/CCND1/IKBKG/TGFB3/PIK3R3/AKT3/RB1/RALBP1/TP53	20
KEGG	hsa04520	Adherens junction	19/1141	71/8135	0.003357	0.01559	0.01097	WASF3/RAC2/PARD3/WASL/EGFR/PTPN6/CREBBP/WAS/ERBB2/TCF7/TCF7L2/PTPRF/LEF1/SMAD3/TCF7L1/SORBS1/FER/NLK/WASF2	19
KEGG	hsa00650	Butanoate metabolism	10/1141	28/8135	0.003363	0.01559	0.01097	OXCT1/ACAT1/BDH2/BDH1/HADH/ACSM5/ECHS1/ACSM3/ALDH5A1/HADHA	10
KEGG	hsa05205	Proteoglycans in cancer	43/1141	205/8135	0.003786	0.0173	0.01218	PIK3R1/IGF1/WNT5B/TIMP3/PLCE1/ANK2/PRKCB/TLR2/HCLS1/CTSL/EGFR/HBEGF/PTPN6/FGF2/DCN/PLCG2/ERBB2/HGF/LUM/PIK3CD/MAPK13/RRAS/FZD4/ARHGEF12/PTPN11/FZD7/VAV1/PPP1CA/PIK3CA/EIF4B/PAK1/CCND1/HOXD10/CTTN/PIK3R3/AKT3/FZD6/KDR/HSPB2/FZD2/ITGAV/TP53/VAV3	43
KEGG	hsa05226	Gastric cancer	33/1141	149/8135	0.004431	0.01997	0.01406	PIK3R1/LRP6/WNT5B/FGF18/FGF7/EGFR/FGF2/ERBB2/TCF7/BAK1/HGF/TCF7L2/LRP5/PIK3CD/FZD4/LEF1/SMAD3/FZD7/TCF7L1/PIK3CA/CCND1/FGF9/TGFB3/PIK3R3/AKT3/FZD6/RB1/SHC2/DVL1/FZD2/TP53/FRAT1/CCNE2	33
KEGG	hsa04657	IL-17 signaling pathway	23/1141	94/8135	0.004595	0.02043	0.01438	TRAF3/TNFAIP3/S100A9/MMP1/CXCL1/CXCL10/CXCL8/NFKBIA/MAPK13/NFKB1/CXCL3/IFNG/CCL7/HSP90AB1/FOSL1/IKBKG/IL6/CXCL2/CXCL5/CXCL6/CCL17/CCL2/IL1B	23
KEGG	hsa05203	Viral carcinogenesis	42/1141	204/8135	0.005904	0.02578	0.01814	TRAF3/CCR5/PIK3R1/IRF9/HLA-F/HLA-A/TRAF1/HLA-C/CCND2/NFKB2/HLA-G/IRF7/HDAC4/HLA-E/CREBBP/HLA-B/CREB3L2/CDK1/BAK1/CCNA2/NFKBIA/PIK3CD/NFKB1/PMAIP1/RASA2/IL6ST/PIK3CA/SYK/CCND1/CHD4/IKBKG/GTF2A1/PIK3R3/MAPKAPK2/CCR8/RB1/CDC20/LYN/TP53/USP7/CCNE2/GSN	42
KEGG	hsa04015	Rap1 signaling pathway	43/1141	210/8135	0.005954	0.02578	0.01814	KITLG/PIK3R1/IGF1/RAC2/PLCE1/FGF18/SIPA1/RALGDS/LAT/PARD3/RASGRP3/LPAR1/PRKCB/ANGPT1/FGF7/LCP2/PFN2/ITGB2/PDGFD/PRKD2/EGFR/FGF2/ITGAL/HGF/MAGI2/ENAH/PIK3CD/MAPK13/SKAP1/RRAS/EFNA5/VASP/VAV1/FPR1/PIK3CA/FGF9/PIK3R3/AKT3/VEGFB/PRKD1/KDR/PFN1/VAV3	43
KEGG	hsa05131	Shigellosis	49/1141	247/8135	0.00659	0.02816	0.01982	CCL5/PIK3R1/PLCE1/PRKCQ/CYTH1/MYD88/SKP1/HCLS1/PFN2/MALT1/WASL/RIPK2/EGFR/HK3/CXCL8/FNBP1/PLCG2/NFKBIA/TLR5/DOCK1/PIK3CD/MAPK13/NFKB1/CASP1/FOXO1/ARPC5L/UBE2D1/CYTH4/PIK3CA/MYL5/FNBP1L/IKBKG/CTTN/PIK3R3/AKT3/FOXO3/MYL9/IL18/NOD1/ARPC1A/WASF2/ACTR3/PFN1/CASP4/TP53/IL1R1/IL1B/ACTR2/NLRP3	49
KEGG	hsa04931	Insulin resistance	25/1141	108/8135	0.006905	0.02913	0.0205	PIK3R1/PPP1R3C/PRKCQ/PRKCB/CD36/RPS6KA1/CREB3L2/PCK1/NFKBIA/PTPRF/PIK3CD/ACACB/NFKB1/FOXO1/PTPN11/GFPT1/PPP1CA/PIK3CA/PIK3R3/AKT3/IL6/NR1H3/SLC27A5/GFPT2/PRKAB1	25
KEGG	hsa04936	Alcoholic liver disease	31/1141	142/8135	0.007093	0.02954	0.02079	TRAF3/ALDH7A1/MYD88/ALDH3A2/ACADVL/ADH1C/CXCL1/CXCL8/TCF7/TCF7L2/NFKBIA/NOX4/ACACB/MAPK13/NFKB1/LEF1/FOXO1/CXCL3/TCF7L1/ADH1B/ADIPOQ/CCND1/IKBKG/AKT3/IL6/ADH5/CXCL2/FOXO3/PRKAB1/IFNA1/IL1B	31
KEGG	hsa05163	Human cytomegalovirus infection	45/1141	225/8135	0.007739	0.03183	0.0224	CCL5/CCR5/PIK3R1/TAP1/TAPBP/HLA-F/GNG12/HLA-A/RAC2/CXCR4/TAP2/HLA-C/PPP3CA/PRKCB/BID/HLA-G/EGFR/HLA-E/CXCL8/HLA-B/CREB3L2/BAK1/SP1/CCR1/NFKBIA/PIK3CD/MAPK13/NFKB1/ARHGEF12/PIK3CA/PTGER4/CCND1/IL10RA/IKBKG/PIK3R3/AKT3/IL6/AKAP13/RB1/ITGAV/TP53/CCL2/IFNA1/IL1R1/IL1B	45
KEGG	hsa04919	Thyroid hormone signaling pathway	27/1141	121/8135	0.008554	0.03467	0.0244	PIK3R1/BMP4/PLCE1/STAT1/PRKCB/DIO2/SLC16A2/CREBBP/PLCG2/PLN/PIK3CD/ATP1B1/FOXO1/NOTCH1/ATP1A2/PIK3CA/CCND1/PIK3R3/AKT3/DIO3/MED14/SLCO1C1/ITGAV/TP53/MED13/THRA/ATP2A3	27
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/1141	77/8135	0.00864	0.03467	0.0244	SGCB/ITGB7/ITGA4/CACNA2D1/SGCA/LAMA2/DAG1/TCF7/TCF7L2/CDH2/SGCD/LEF1/ITGA10/DSC2/TCF7L1/SLC8A1/LMNA/ITGAV/ATP2A3	19
KEGG	hsa05165	Human papillomavirus infection	62/1141	331/8135	0.009133	0.03585	0.02524	TRAF3/PIK3R1/IRF1/IRF9/WNT5B/HLA-F/ITGB7/HLA-A/STAT1/ITGA4/HLA-C/CCND2/PARD3/PPP2CA/TCIRG1/MX2/LAMA2/HLA-G/COMP/EGFR/HLA-E/CREBBP/THBS4/OASL/HLA-B/CREB3L2/TCF7/BAK1/CCNA2/TCF7L2/PIK3CD/PPP2CB/NFKB1/FZD4/FOXO1/FZD7/NOTCH1/ITGA10/TCF7L1/PIK3CA/HEY2/PTGER4/CCND1/CHD4/IKBKG/PIK3R3/AKT3/FZD6/RB1/MPP5/TUBG2/HEY1/DVL1/MX1/FZD2/ITGAV/TP53/ATP6V1B2/CCNE2/IFNA1/TYK2/ISG15	62
KEGG	hsa04010	MAPK signaling pathway	56/1141	294/8135	0.009154	0.03585	0.02524	RELB/KITLG/IGF1/RASGRP1/GNG12/RAC2/FGF18/MYD88/NTRK2/CACNA2D1/PPP3CA/RASGRP3/DUSP5/NFKB2/PRKCB/ANGPT1/FGF7/MAP3K11/PTPN7/PDGFD/MAP3K8/RPS6KA1/EGFR/FGF2/CDC25B/HSPA6/MAP4K1/ERBB2/HGF/MAPK13/RRAS/RPS6KA4/NFKB1/PLA2G4C/EFNA5/RASA2/MAP3K2/FLT3/PAK1/FGF9/IKBKG/TGFB3/HSPB1/AKT3/MAPKAPK2/DUSP6/ECSIT/DUSP2/DDIT3/NLK/VEGFB/KDR/HSPA1L/TP53/IL1R1/IL1B	56
KEGG	hsa05161	Hepatitis B	34/1141	162/8135	0.009274	0.0359	0.02527	TRAF3/PIK3R1/STAT1/MYD88/PRKCB/TLR2/BID/IRF7/JAK2/IFIH1/STAT4/CREBBP/CASP10/CXCL8/CREB3L2/CCNA2/NFKBIA/PIK3CD/MAPK13/DDX58/NFKB1/SMAD3/PIK3CA/IKBKG/TGFB3/PIK3R3/AKT3/APAF1/IL6/RB1/TP53/CCNE2/IFNA1/TYK2	34
KEGG	hsa05143	African trypanosomiasis	11/1141	37/8135	0.01029	0.03937	0.02771	IDO1/APOL1/MYD88/PRKCB/HBB/ICAM1/SELE/IFNG/IL6/IL18/IL1B	11
KEGG	hsa00380	Tryptophan metabolism	12/1141	42/8135	0.01053	0.03981	0.02802	IDO1/ALDH7A1/KYNU/ALDH3A2/ACAT1/MAOA/KMO/MAOB/CAT/HADH/ECHS1/HADHA	12
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1141	79/8135	0.01144	0.04239	0.02984	PIK3R1/IGF1/PRKCB/AXL/JAK2/PDGFD/EGFR/FGF2/PLCG2/ERBB2/HGF/PIK3CD/PIK3CA/PIK3R3/AKT3/IL6/FOXO3/KDR/SHC2	19
KEGG	hsa04360	Axon guidance	37/1141	182/8135	0.01147	0.04239	0.02984	PIK3R1/EPHA3/SEMA4A/WNT5B/RAC2/CXCR4/SEMA4D/SEMA3A/PARD3/PPP3CA/LIMK2/PLCG2/NEO1/ENAH/EPHB1/PIK3CD/UNC5C/RYK/RRAS/TRPC1/ARHGEF12/SEMA3F/EFNA5/PTPN11/ABLIM1/PIK3CA/MYL5/PAK1/RHOD/PIK3R3/DPYSL2/SSH3/CFL1/SEMA4F/MYL9/SEMA3E/SEMA6B	37
KEGG	hsa00480	Glutathione metabolism	15/1141	58/8135	0.012	0.04337	0.03053	LAP3/GSTM5/GSTM3/GSTA4/RRM2/LANCL1/IDH2/HPGDS/GPX3/PGD/GPX4/PRDX6/ANPEP/GSTO1/GSTM2	15
KEGG	hsa05213	Endometrial cancer	15/1141	58/8135	0.012	0.04337	0.03053	PIK3R1/EGFR/ERBB2/TCF7/BAK1/TCF7L2/PIK3CD/LEF1/TCF7L1/PIK3CA/CCND1/PIK3R3/AKT3/FOXO3/TP53	15
KEGG	hsa01232	Nucleotide metabolism	20/1141	85/8135	0.0123	0.04398	0.03096	ENPP1/AMPD3/TYMP/NT5E/HDDC2/UPP1/ADK/RRM2/NME7/ADA/AK1/PNP/ENTPD1/TYMS/ENTPD4/NME4/CANT1/TK2/TK1/AK6	20
KEGG	hsa04920	Adipocytokine signaling pathway	17/1141	69/8135	0.01279	0.04523	0.03184	TNFRSF1B/PRKCQ/NFKBIE/JAK2/CD36/PCK1/NFKBIA/ACACB/NFKB1/PTPN11/LEP/ADIPOQ/IKBKG/AKT3/IRS4/PRKAB1/ACSL5	17
KEGG	hsa05415	Diabetic cardiomyopathy	40/1141	203/8135	0.01474	0.05114	0.036	PIK3R1/RAC2/NDUFC1/NDUFA4L2/PRKCB/NDUFS2/COX7A1/CD36/NDUFS4/MPC2/SP1/PLN/NCF4/PIK3CD/NDUFA13/MAPK13/NFKB1/SMAD3/SLC25A4/GFPT1/AGTR1/PPP1CA/PIK3CA/PDK4/PARP1/TGFB3/PIK3R3/AKT3/NDUFA9/MPC1/CYBA/SLC25A5/SDHA/NDUFB6/REN/NCF1/GFPT2/NDUFA4/COX7A2/ATP2A3	40
KEGG	hsa05222	Small cell lung cancer	21/1141	92/8135	0.01477	0.05114	0.036	TRAF3/PIK3R1/BIRC3/TRAF1/LAMA2/BAK1/NFKBIA/PIK3CD/NFKB1/CKS2/PIK3CA/CCND1/IKBKG/CKS1B/PIK3R3/AKT3/APAF1/RB1/ITGAV/TP53/CCNE2	21
KEGG	hsa05218	Melanoma	17/1141	72/8135	0.01937	0.06637	0.04672	PIK3R1/IGF1/FGF18/FGF7/PDGFD/EGFR/FGF2/BAK1/HGF/PIK3CD/PIK3CA/CCND1/FGF9/PIK3R3/AKT3/RB1/TP53	17
KEGG	hsa04014	Ras signaling pathway	44/1141	232/8135	0.02073	0.07031	0.04949	PLA2G2D/KITLG/PIK3R1/IGF1/RASGRP1/GNG12/RAC2/PLCE1/FGF18/RALGDS/NTRK2/LAT/RASGRP3/PRKCB/ANGPT1/FGF7/PDGFD/EGFR/FGF2/ZAP70/PLCG2/HGF/PLD1/PLA2G12A/PIK3CD/RRAS/NFKB1/PLA2G4C/EFNA5/PTPN11/RASA2/PIK3CA/FLT3/PLA1A/PAK1/FGF9/IKBKG/PIK3R3/AKT3/RALBP1/GAB2/VEGFB/KDR/SHC2	44
KEGG	hsa04213	Longevity regulating pathway - multiple species	15/1141	62/8135	0.02193	0.07361	0.05181	PIK3R1/IGF1/CRYAB/HSPA6/PIK3CD/SOD1/FOXO1/PIK3CA/PIK3R3/AKT3/FOXO3/HSPA1L/CAT/IRS4/PRKAB1	15
KEGG	hsa04623	Cytosolic DNA-sensing pathway	15/1141	63/8135	0.02517	0.08365	0.05888	CCL5/AIM2/IRF7/CXCL10/NFKBIA/DDX58/NFKB1/CASP1/ADAR/POLR2L/IKBKG/IL6/IL18/IFNA1/IL1B	15
KEGG	hsa00620	Pyruvate metabolism	12/1141	47/8135	0.02568	0.08448	0.05946	ALDH7A1/ALDH3A2/ADH1C/PC/ACAT1/PCK1/ACACB/GLO1/ADH1B/MDH1/ADH5/HAGH	12
KEGG	hsa00240	Pyrimidine metabolism	14/1141	58/8135	0.02679	0.08728	0.06143	ENPP1/TYMP/NT5E/HDDC2/UPP1/RRM2/NME7/ENTPD1/TYMS/ENTPD4/NME4/CANT1/TK2/TK1	14
KEGG	hsa05220	Chronic myeloid leukemia	17/1141	76/8135	0.03184	0.1027	0.07228	PIK3R1/BAK1/NFKBIA/PIK3CD/NFKB1/SMAD3/PTPN11/PIK3CA/CCND1/IKBKG/TGFB3/PIK3R3/AKT3/RB1/GAB2/SHC2/TP53	17
KEGG	hsa05100	Bacterial invasion of epithelial cells	17/1141	77/8135	0.03572	0.1141	0.0803	PIK3R1/HCLS1/ARHGEF26/WASL/DNM1/DOCK1/PIK3CD/ARPC5L/RHOG/PIK3CA/CTTN/PIK3R3/SHC2/ARPC1A/WASF2/ACTR3/ACTR2	17
KEGG	hsa05223	Non-small cell lung cancer	16/1141	72/8135	0.03864	0.1222	0.08605	PIK3R1/EML4/PRKCB/EGFR/PLCG2/ERBB2/BAK1/HGF/PIK3CD/PIK3CA/CCND1/PIK3R3/AKT3/FOXO3/RB1/TP53	16
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	28/1141	143/8135	0.03961	0.1241	0.08737	PIK3R1/BMP4/IGF1/WNT5B/INHBA/MEIS1/ZFHX3/BMPR1A/JAK2/FGF2/TCF7/SOX2/ID3/PIK3CD/MAPK13/FZD4/SMAD3/FZD7/IL6ST/PIK3CA/ACVR1/PIK3R3/AKT3/FZD6/JARID2/LIFR/DVL1/FZD2	28
KEGG	hsa04914	Progesterone-mediated oocyte maturation	21/1141	102/8135	0.04284	0.1321	0.09299	PIK3R1/STK10/IGF1/BUB1/CCNB2/MAD2L1/PLK1/RPS6KA1/CPEB1/CDC25B/CDK1/CCNA2/PIK3CD/MAPK13/CCNB1/PIK3CA/HSP90AB1/PIK3R3/AKT3/PDE3B/AURKA	21
KEGG	hsa04923	Regulation of lipolysis in adipocytes	13/1141	56/8135	0.04297	0.1321	0.09299	PIK3R1/NPY1R/PIK3CD/PLIN1/PIK3CA/PIK3R3/AKT3/PTGS1/PRKG1/FABP4/PDE3B/IRS4/PRKG2	13
KEGG	hsa04152	AMPK signaling pathway	24/1141	120/8135	0.0434	0.1322	0.09305	PIK3R1/CAB39L/IGF1/RAB8A/PPP2CA/CD36/CREB3L2/CCNA2/PCK1/PIK3CD/ACACB/TBC1D1/PPP2CB/FOXO1/LEP/PIK3CA/ADIPOQ/CCND1/PIK3R3/AKT3/FOXO3/IRS4/PRKAB1/RAB14	24
KEGG	hsa04390	Hippo signaling pathway	30/1141	157/8135	0.04547	0.1372	0.0966	GDF5/BMP4/BIRC3/WNT5B/DLG5/CCND2/PARD3/PPP2CA/ITGB2/BMPR1A/YAP1/TCF7/TCF7L2/SOX2/PPP2CB/FZD4/LEF1/SMAD3/FZD7/PPP1CA/TCF7L1/CCND1/TGFB3/WWTR1/FZD6/MPP5/DVL1/TP53BP2/FZD2/TEAD4	30
KEGG	hsa05210	Colorectal cancer	18/1141	86/8135	0.05023	0.1502	0.1057	PIK3R1/RAC2/RALGDS/EGFR/TCF7/BAK1/TCF7L2/PIK3CD/PMAIP1/LEF1/SMAD3/TCF7L1/PIK3CA/CCND1/TGFB3/PIK3R3/AKT3/TP53	18
KEGG	hsa05217	Basal cell carcinoma	14/1141	63/8135	0.05089	0.1508	0.1062	BMP4/WNT5B/GLI3/TCF7/BAK1/TCF7L2/FZD4/LEF1/FZD7/TCF7L1/FZD6/DVL1/FZD2/TP53	14
KEGG	hsa00350	Tyrosine metabolism	9/1141	36/8135	0.05613	0.1649	0.1161	FAH/ADH1C/MAOA/HPD/ADH1B/AOC2/MAOB/ADH5/AOC3	9
KEGG	hsa00410	beta-Alanine metabolism	8/1141	31/8135	0.05921	0.17	0.1197	ALDH7A1/ALDH3A2/ALDH6A1/CNDP2/AOC2/AOC3/ECHS1/HADHA	8
KEGG	hsa05310	Asthma	8/1141	31/8135	0.05921	0.17	0.1197	MS4A2/CD40/HLA-DRA/HLA-DPB1/CD40LG/HLA-DMA/HLA-DMB/HLA-DPA1	8
KEGG	hsa04310	Wnt signaling pathway	31/1141	167/8135	0.05942	0.17	0.1197	SFRP1/LRP6/WNT5B/RAC2/CCND2/PPP3CA/PRKCB/SKP1/CBY1/CREBBP/TCF7/TCF7L2/LRP5/RYK/FZD4/LEF1/SMAD3/FZD7/DAAM2/TCF7L1/CCND1/FOSL1/GPC4/FZD6/NLK/DVL1/FZD2/TP53/WIF1/FRAT1/TBL1X	31
KEGG	hsa04350	TGF-beta signaling pathway	19/1141	94/8135	0.06115	0.1721	0.1211	GDF5/BMP4/FMOD/INHBA/PPP2CA/SKP1/BMPR1A/CREBBP/DCN/NEO1/SP1/ID3/PPP2CB/SMAD3/NBL1/IFNG/ACVR1/TGFB3/FST	19
KEGG	hsa04932	Non-alcoholic fatty liver disease	29/1141	155/8135	0.06119	0.1721	0.1211	PIK3R1/NDUFC1/NDUFA4L2/BID/NDUFS2/COX7A1/MAP3K11/NDUFS4/CXCL8/PIK3CD/NDUFA13/MAPK13/NFKB1/LEP/PIK3CA/ADIPOQ/PIK3R3/AKT3/NDUFA9/IL6/DDIT3/NR1H3/CEBPA/SDHA/NDUFB6/PRKAB1/NDUFA4/IL1B/COX7A2	29
KEGG	hsa00360	Phenylalanine metabolism	5/1141	16/8135	0.06204	0.173	0.1218	MAOA/HPD/AOC2/MAOB/AOC3	5
KEGG	hsa00280	Valine, leucine and isoleucine degradation	11/1141	48/8135	0.06467	0.1783	0.1255	ALDH7A1/ALDH3A2/OXCT1/ALDH6A1/MCCC1/ACAT1/PCCA/BCKDHB/HADH/ECHS1/HADHA	11
KEGG	hsa05216	Thyroid cancer	9/1141	37/8135	0.06533	0.1783	0.1255	TPR/TCF7/BAK1/TCF7L2/LEF1/CCDC6/TCF7L1/CCND1/TP53	9
KEGG	hsa04071	Sphingolipid signaling pathway	23/1141	119/8135	0.06558	0.1783	0.1255	PIK3R1/RAC2/PPP2CA/MS4A2/PRKCB/BID/SGPL1/SPHK1/ADORA3/PLD1/PIK3CD/MAPK13/PPP2CB/NFKB1/PIK3CA/PIK3R3/AKT3/SGMS1/GAB2/S1PR1/TP53/S1PR4/CERS4	23
KEGG	hsa00640	Propanoate metabolism	8/1141	32/8135	0.06965	0.1878	0.1322	ALDH6A1/ACSS3/ACACB/PCCA/SUCLA2/BCKDHB/ECHS1/HADHA	8
KEGG	hsa05146	Amoebiasis	20/1141	102/8135	0.07255	0.1939	0.1364	PIK3R1/GNAL/PRKCB/TLR2/ITGB2/LAMA2/CXCL1/CXCL8/PIK3CD/NFKB1/CXCL3/IFNG/PIK3CA/TGFB3/HSPB1/PIK3R3/IL6/CXCL2/IL1R1/IL1B	20
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1141	49/8135	0.0733	0.1939	0.1364	GALT/HK3/CYB5R3/CYB5R4/CYB5R1/UGDH/NANS/NAGK/GFPT1/UGP2/GFPT2	11
KEGG	hsa00062	Fatty acid elongation	7/1141	27/8135	0.07365	0.1939	0.1364	HSD17B12/ELOVL4/ELOVL2/HADH/ECHS1/ELOVL5/HADHA	7
KEGG	hsa00340	Histidine metabolism	6/1141	22/8135	0.07683	0.2006	0.1412	ALDH7A1/ALDH3A2/CNDP2/ASPA/MAOA/MAOB	6
KEGG	hsa04151	PI3K-Akt signaling pathway	59/1141	354/8135	0.08522	0.2208	0.1554	IL2RG/KITLG/PIK3R1/IGF1/GNG12/ITGB7/FGF18/IL2RB/IL3RA/IL7R/ITGA4/NTRK2/CCND2/PPP2CA/LPAR1/TLR2/ANGPT1/FGF7/IL4R/LAMA2/JAK2/PDGFD/COMP/EGFR/FGF2/THBS4/GHR/ERBB2/CREB3L2/HGF/MAGI2/PCK1/PIK3CD/PPP2CB/NFKB1/CD19/EFNA5/ITGA10/PIK3CA/PRL/FLT3/HSP90AB1/EIF4B/SYK/PHLPP1/CCND1/FGF9/IKBKG/PIK3R3/AKT3/IL6/FOXO3/VEGFB/KDR/IL2RA/ITGAV/TP53/CCNE2/IFNA1	59
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	19/1141	98/8135	0.086	0.221	0.1556	PIK3R1/IGF1/PRKCH/PRKCQ/PRKCB/HTR2B/TRPV2/PLCG2/PIK3CD/MAPK13/PLA2G4C/HTR2A/HRH1/PPP1CA/PIK3CA/PTGER4/PIK3R3/IL1R1/IL1B	19
KEGG	hsa04072	Phospholipase D signaling pathway	27/1141	148/8135	0.08828	0.2252	0.1585	KITLG/PIK3R1/RALGDS/CYTH1/MS4A2/LPAR1/PDGFD/DNM1/EGFR/SPHK1/CXCL8/PLCG2/PLD1/PIK3CD/RRAS/PLA2G4C/PTPN11/AGTR1/CYTH4/DGKA/PIK3CA/PTGFR/SYK/PIK3R3/AKT3/GAB2/SHC2	27
KEGG	hsa04144	Endocytosis	43/1141	251/8135	0.09138	0.2313	0.1628	IL2RG/CCR5/HLA-F/HLA-A/CXCR4/GRK6/IL2RB/CYTH1/HLA-C/RAB8A/PARD3/HLA-G/ACAP1/WASL/DNM1/TFRC/EGFR/HLA-E/HSPA6/HLA-B/AGAP1/PLD1/ASAP2/EHD4/SNX5/SMAD3/PSD3/VPS37C/ARPC5L/CYTH4/PSD4/CHMP2B/CAPZA1/HSPA1L/ARPC1A/ACTR3/RAB11FIP2/IL2RA/SH3GL3/ACTR2/CHMP1B/PML/RAB11FIP1	43
KEGG	hsa00310	Lysine degradation	13/1141	63/8135	0.09524	0.2349	0.1654	COLGALT2/ALDH7A1/ALDH3A2/KMT2A/EZH2/ACAT1/SMYD2/HADH/AASS/SETMAR/ECHS1/EZH1/HADHA	13
KEGG	hsa03250	Viral life cycle - HIV-1	13/1141	63/8135	0.09524	0.2349	0.1654	CCR5/CXCR4/SERINC3/APOBEC3G/MX2/APOBEC3B/CREBBP/CPSF6/CCNT1/FEZ1/MAP1B/MX1/PSIP1	13
KEGG	hsa03320	PPAR signaling pathway	15/1141	75/8135	0.09568	0.2349	0.1654	GK/MMP1/ACOX2/CD36/PCK1/ANGPTL4/PLIN1/ADIPOQ/FABP5/SORBS1/NR1H3/FABP4/SLC27A5/ACADL/ACSL5	15
KEGG	hsa05214	Glioma	15/1141	75/8135	0.09568	0.2349	0.1654	PIK3R1/IGF1/PRKCB/EGFR/PLCG2/BAK1/CAMK1D/PIK3CD/PIK3CA/CCND1/PIK3R3/AKT3/RB1/SHC2/TP53	15
KEGG	hsa04510	Focal adhesion	35/1141	201/8135	0.0996	0.2427	0.1708	PIK3R1/IGF1/BIRC3/ITGB7/RAC2/ITGA4/CCND2/PRKCB/LAMA2/PDGFD/COMP/EGFR/THBS4/ERBB2/HGF/DOCK1/PIK3CD/PARVA/VASP/VAV1/ITGA10/PPP1CA/PIK3CA/MYL5/PAK1/CCND1/PIK3R3/AKT3/MYL9/VEGFB/KDR/SHC2/MYLK/ITGAV/VAV3	35
KEGG	hsa04392	Hippo signaling pathway - multiple species	7/1141	29/8135	0.1013	0.2451	0.1725	YAP1/DCHS1/RASSF4/PAK1/WWTR1/FAT4/TEAD4	7
KEGG	hsa05133	Pertussis	15/1141	76/8135	0.1045	0.2511	0.1767	IRF1/MYD88/IRF8/ITGB2/CXCL8/MAPK13/NFKB1/CASP1/IL6/CFL1/CXCL5/CXCL6/NOD1/IL1B/NLRP3	15
KEGG	hsa04613	Neutrophil extracellular trap formation	33/1141	190/8135	0.1101	0.262	0.1844	PIK3R1/TLR8/RAC2/PRKCB/TLR2/ITGB2/AQP9/CLCN4/HDAC4/ITGAL/CLEC7A/CR1/PLCG2/NCF4/PIK3CD/MAPK13/NFKB1/CASP1/SLC25A4/FPR1/PIK3CA/SYK/PIK3R3/AKT3/SELPLG/FPR2/CYBA/SLC25A5/GP1BA/NCF1/CLCN5/CASP4/FCGR3B	33
KEGG	hsa05219	Bladder cancer	9/1141	41/8135	0.1112	0.262	0.1844	TYMP/MMP1/EGFR/HBEGF/CXCL8/ERBB2/CCND1/RB1/TP53	9
KEGG	hsa04211	Longevity regulating pathway	17/1141	89/8135	0.1115	0.262	0.1844	PIK3R1/IGF1/CREB3L2/PIK3CD/NFKB1/FOXO1/KL/PIK3CA/ADIPOQ/PIK3R3/AKT3/FOXO3/SESN1/CAT/IRS4/TP53/PRKAB1	17
KEGG	hsa04973	Carbohydrate digestion and absorption	10/1141	47/8135	0.1135	0.2649	0.1864	PIK3R1/PRKCB/HK3/PIK3CD/ATP1B1/ATP1A2/PIK3CA/PIK3R3/AKT3/SLC2A5	10
KEGG	hsa00030	Pentose phosphate pathway	7/1141	30/8135	0.117	0.271	0.1908	ALDOC/RPIA/PGD/RGN/TALDO1/TKTL1/PRPS2	7
KEGG	hsa05410	Hypertrophic cardiomyopathy	17/1141	90/8135	0.1204	0.2753	0.1938	SGCB/IGF1/ITGB7/ITGA4/CACNA2D1/SGCA/LAMA2/DAG1/SGCD/ITGA10/SLC8A1/TGFB3/IL6/LMNA/ITGAV/PRKAB1/ATP2A3	17
KEGG	hsa01200	Carbon metabolism	21/1141	115/8135	0.1205	0.2753	0.1938	ALDH6A1/HK3/ESD/ALDOC/PC/IDH2/ACAT1/RPIA/PGD/PCCA/SUCLA2/PSPH/RGN/MDH1/ADH5/SDHA/CAT/ECHS1/TALDO1/TKTL1/PRPS2	21
KEGG	hsa03030	DNA replication	8/1141	36/8135	0.1219	0.2766	0.1947	LIG1/MCM5/RFC3/FEN1/MCM2/POLE2/RNASEH2A/MCM4	8
KEGG	hsa04066	HIF-1 signaling pathway	20/1141	109/8135	0.1229	0.2769	0.1949	PIK3R1/IGF1/PRKCB/ANGPT1/TFRC/EGFR/HK3/ALDOC/CREBBP/PLCG2/ERBB2/PIK3CD/NFKB1/IFNG/ARNT/PIK3CA/PIK3R3/AKT3/IL6/CUL2	20
KEGG	hsa04610	Complement and coagulation cascades	16/1141	85/8135	0.132	0.2954	0.2079	SERPINA1/CLU/SERPINA5/ITGB2/PROS1/F5/PROCR/CR1/PLAT/CFD/C7/ITGAX/TFPI/CFB/CR2/C6	16
KEGG	hsa04115	p53 signaling pathway	14/1141	73/8135	0.1359	0.2996	0.2109	IGF1/CCND2/BID/CCNB2/RRM2/CDK1/PMAIP1/CCNB1/CCND1/APAF1/SESN1/CCNG1/TP53/CCNE2	14
KEGG	hsa05231	Choline metabolism in cancer	18/1141	98/8135	0.1369	0.2996	0.2109	WASF3/PIK3R1/RAC2/RALGDS/CHPT1/PRKCB/PDGFD/EGFR/WAS/SP1/PLD1/PIK3CD/PLA2G4C/DGKA/PIK3CA/PIK3R3/AKT3/WASF2	18
KEGG	hsa01250	Biosynthesis of nucleotide sugars	8/1141	37/8135	0.1375	0.2996	0.2109	GALT/HK3/UGDH/NANS/NAGK/GFPT1/UGP2/GFPT2	8
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	8/1141	37/8135	0.1375	0.2996	0.2109	PIK3R1/IGF1/PRKCB/PIK3CD/ATP1B1/ATP1A2/PIK3CA/PIK3R3	8
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1141	26/8135	0.147	0.316	0.2224	PIGK/GPAA1/PIGH/PIGP/PIGT/PIGF	6
KEGG	hsa00790	Folate biosynthesis	6/1141	26/8135	0.147	0.316	0.2224	GCH1/AKR1C3/PCBD1/AKR1B1/MOCS2/ALPL	6
KEGG	hsa04114	Oocyte meiosis	23/1141	131/8135	0.1479	0.316	0.2224	IGF1/PTTG1/PPP2CA/PPP3CA/BUB1/SKP1/CCNB2/AR/MAD2L1/PLK1/RPS6KA1/CPEB1/CDK1/MAPK13/PPP2CB/STAG3/CCNB1/PPP1CA/FBXO5/REC8/CDC20/CCNE2/AURKA	23
KEGG	hsa04722	Neurotrophin signaling pathway	21/1141	119/8135	0.1554	0.3298	0.2321	PIK3R1/ARHGDIB/NTRK2/SH2B2/NFKBIE/RIPK2/RPS6KA1/PLCG2/NFKBIA/PIK3CD/MAPK13/NFKB1/PTPN11/PIK3CA/PIK3R3/AKT3/MAPKAPK2/FOXO3/SH2B3/SHC2/TP53	21
KEGG	hsa04142	Lysosome	23/1141	132/8135	0.1567	0.3305	0.2326	LAMP3/AP1G2/SLC17A5/CTSF/TCIRG1/DMXL2/CTSC/CTSL/CTSW/NPC1/ACP2/CTSO/CTSB/HYAL1/IDUA/FUCA1/SCARB2/GLA/MAN2B1/ENTPD4/CD164/MANBA/CTSH	23
KEGG	hsa01212	Fatty acid metabolism	11/1141	57/8135	0.1673	0.3505	0.2467	ACADVL/ACAT1/HSD17B12/ELOVL4/ACADL/ELOVL2/HADH/ECHS1/ACSL5/ELOVL5/HADHA	11
KEGG	hsa04130	SNARE interactions in vesicular transport	7/1141	33/8135	0.1708	0.3557	0.2504	STX16/STX18/STX4/VAMP2/STX6/VTI1B/USE1	7
KEGG	hsa04622	RIG-I-like receptor signaling pathway	13/1141	70/8135	0.175	0.3599	0.2533	TRAF3/IRF7/IFIH1/CXCL10/CASP10/CXCL8/NFKBIA/MAPK13/DDX58/NFKB1/IKBKG/IFNA1/ISG15	13
KEGG	hsa05230	Central carbon metabolism in cancer	13/1141	70/8135	0.175	0.3599	0.2533	PIK3R1/SCO2/EGFR/HK3/IDH2/ERBB2/PIK3CD/SLC7A5/PIK3CA/FLT3/PIK3R3/AKT3/TP53	13
KEGG	hsa05150	Staphylococcus aureus infection	17/1141	96/8135	0.1827	0.3733	0.2628	ITGB2/ICAM1/ITGAL/HLA-DRA/HLA-DPB1/CFD/HLA-DMA/HLA-DMB/FPR1/KRT19/SELPLG/HLA-DPA1/FPR2/CFB/KRT10/FCGR3B/KRT33B	17
KEGG	hsa04930	Type II diabetes mellitus	9/1141	46/8135	0.1878	0.3814	0.2684	PIK3R1/SOCS1/HK3/SOCS2/PIK3CD/PIK3CA/ADIPOQ/PIK3R3/IRS4	9
KEGG	hsa00260	Glycine, serine and threonine metabolism	8/1141	40/8135	0.1898	0.3832	0.2697	ALDH7A1/CBS/MAOA/ALAS1/PSPH/AOC2/MAOB/AOC3	8
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1141	11/8135	0.1921	0.3854	0.2713	NQO1/VKORC1/HPD	3
KEGG	hsa00982	Drug metabolism - cytochrome P450	13/1141	72/8135	0.2025	0.4038	0.2842	FMO2/GSTM5/ADH1C/GSTM3/GSTA4/MAOA/HPGDS/ADH1B/MAOB/ADH5/UGT2B17/GSTO1/GSTM2	13
KEGG	hsa04611	Platelet activation	21/1141	124/8135	0.2059	0.4068	0.2863	PIK3R1/RASGRP1/LCP2/PLCG2/PIK3CD/MAPK13/PLA2G4C/ARHGEF12/VASP/PPP1CA/PIK3CA/SYK/PIK3R3/BTK/AKT3/PTGS1/PRKG1/LYN/MYLK/GP1BA/PRKG2	21
KEGG	hsa01522	Endocrine resistance	17/1141	98/8135	0.2065	0.4068	0.2863	CDKN2C/PIK3R1/IGF1/EGFR/HBEGF/ERBB2/SP1/PIK3CD/MAPK13/NOTCH1/PIK3CA/CCND1/PIK3R3/AKT3/RB1/SHC2/TP53	17
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	5/1141	23/8135	0.2125	0.4162	0.2929	PCK1/ATP1B1/CA2/ATP1A2/MDH1	5
KEGG	hsa01240	Biosynthesis of cofactors	25/1141	153/8135	0.2333	0.4539	0.3195	GCH1/IDO1/NQO1/KYNU/ALDH3A2/NME7/DHRS3/MTHFD2/VKORC1/AK1/MOCS2/HPD/MAT1A/UGDH/ALAS1/KMO/RGN/ALPL/UGP2/UGT2B17/HMBS/NME4/LIPT1/ALAD/AK6	25
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/1141	30/8135	0.2373	0.4539	0.3195	PC/IDH2/PCK1/SUCLA2/MDH1/SDHA	6
KEGG	hsa00053	Ascorbate and aldarate metabolism	6/1141	30/8135	0.2373	0.4539	0.3195	ALDH7A1/ALDH3A2/KL/UGDH/RGN/UGT2B17	6
KEGG	hsa01523	Antifolate resistance	6/1141	30/8135	0.2373	0.4539	0.3195	ABCC4/NFKB1/IKBKG/IL6/TYMS/IL1B	6
KEGG	hsa05211	Renal cell carcinoma	12/1141	69/8135	0.255	0.4849	0.3413	PIK3R1/CREBBP/HGF/PIK3CD/PTPN11/ARNT/PIK3CA/PAK1/TGFB3/PIK3R3/AKT3/CUL2	12
KEGG	hsa04979	Cholesterol metabolism	9/1141	50/8135	0.2617	0.4901	0.3449	CD36/NPC1/LRPAP1/ANGPTL4/LIPG/MYLIP/CETP/LIPC/SOAT2	9
KEGG	hsa00052	Galactose metabolism	6/1141	31/8135	0.2622	0.4901	0.3449	GALT/AKR1B1/HK3/UGP2/GLA/B4GALT2	6
KEGG	hsa04710	Circadian rhythm	6/1141	31/8135	0.2622	0.4901	0.3449	SKP1/PER2/BHLHE41/ARNTL/PER3/PRKAB1	6
KEGG	hsa05414	Dilated cardiomyopathy	16/1141	96/8135	0.2664	0.4952	0.3486	SGCB/IGF1/ITGB7/ITGA4/CACNA2D1/SGCA/LAMA2/DAG1/PLN/SGCD/ITGA10/SLC8A1/TGFB3/LMNA/ITGAV/ATP2A3	16
KEGG	hsa04962	Vasopressin-regulated water reabsorption	8/1141	44/8135	0.2701	0.4992	0.3514	DYNC2LI1/ARHGDIB/DYNC1LI2/CREB3L2/DYNC1I1/STX4/DCTN6/VAMP2	8
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	13/1141	78/8135	0.2948	0.5419	0.3815	EPHX1/GSTM5/ADH1C/GSTM3/GSTA4/AKR1C1/HPGDS/ADH1B/ADH5/UGT2B17/GSTO1/GSTM2/AKR7A2	13
KEGG	hsa04935	Growth hormone synthesis, secretion and action	19/1141	119/8135	0.3069	0.5609	0.3948	PIK3R1/IGF1/STAT1/PRKCB/JAK2/SOCS1/CREBBP/PLCG2/GHR/CREB3L2/SOCS2/PIK3CD/MAPK13/SSTR5/PIK3CA/PIK3R3/AKT3/SHC2/IRS4	19
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1141	14/8135	0.3121	0.5674	0.3994	B3GNT2/FUT8/B4GALT2	3
KEGG	hsa00983	Drug metabolism - other enzymes	13/1141	80/8135	0.3281	0.5931	0.4175	TYMP/GSTM5/UPP1/GSTM3/GSTA4/RRM2/NME7/UGT2B17/NME4/GSTO1/GSTM2/TK2/TK1	13
KEGG	hsa04530	Tight junction	26/1141	169/8135	0.336	0.604	0.4251	MYH10/RAB8A/PARD3/PPP2CA/ARHGEF18/JAM3/HCLS1/TUBA4A/AMOTL2/ARHGAP17/WAS/ERBB2/PPP2CB/VASP/ARPC5L/CCND1/CTTN/MYH11/MYL9/MPP5/ARPC1A/MYL6B/ACTR3/PRKAB1/CLDN14/ACTR2	26
KEGG	hsa00590	Arachidonic acid metabolism	10/1141	61/8135	0.3492	0.6226	0.4382	PLA2G2D/LTC4S/AKR1C3/PLA2G12A/HPGDS/PLA2G4C/GPX3/PTGS1/EPHX2/ALOX5	10
KEGG	hsa04216	Ferroptosis	7/1141	41/8135	0.3501	0.6226	0.4382	LPCAT3/CP/TFRC/SLC39A8/GPX4/TP53/ACSL5	7
KEGG	hsa04020	Calcium signaling pathway	36/1141	240/8135	0.3574	0.6322	0.445	GNAL/PLCE1/FGF18/CXCR4/NTRK2/PPP3CA/PRKCB/FGF7/PDGFD/HTR2B/EGFR/FGF2/SPHK1/PDE1A/PLCG2/PHKB/ERBB2/HGF/PLN/ASPH/CAMK1D/HTR2A/HRH1/SLC25A4/AGTR1/PTGFR/SLC8A1/EDNRB/FGF9/CD38/RYR3/VEGFB/SLC25A5/KDR/MYLK/ATP2A3	36
KEGG	hsa04910	Insulin signaling pathway	21/1141	137/8135	0.3653	0.6426	0.4523	PIK3R1/PPP1R3C/SH2B2/SOCS1/HK3/PHKB/SOCS2/PCK1/PTPRF/PIK3CD/ACACB/FOXO1/PPP1CA/PIK3CA/SORBS1/PIK3R3/AKT3/PDE3B/SHC2/IRS4/PRKAB1	21
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/1141	22/8135	0.373	0.6528	0.4595	PCYOX1/PMVK/ACAT1/ICMT	4
KEGG	hsa04070	Phosphatidylinositol signaling system	15/1141	97/8135	0.3839	0.6683	0.4704	PIK3R1/PLCE1/PRKCB/PIP4K2B/PLCG2/MTMR14/PIK3CD/INPP1/DGKA/PIK3CA/PIK3R3/PPIP5K1/INPP5D/PIP4K2A/MTMR2	15
KEGG	hsa00510	N-Glycan biosynthesis	8/1141	50/8135	0.403	0.6978	0.4912	MGAT4C/ALG6/DPM3/MAN1C1/STT3A/MAN2A2/FUT8/B4GALT2	8
KEGG	hsa04614	Renin-angiotensin system	4/1141	23/8135	0.4068	0.6987	0.4918	AGTR1/CPA3/ANPEP/REN	4
KEGG	hsa05020	Prion disease	40/1141	273/8135	0.4078	0.6987	0.4918	CCL5/PIK3R1/RAC2/NDUFC1/NDUFA4L2/PPP3CA/NDUFS2/COX7A1/TUBA4A/NDUFS4/TUBB2B/HSPA6/CREB3L2/TUBB4A/NCF4/PIK3CD/NDUFA13/SOD1/MAPK13/ADRM1/NOTCH1/SLC25A4/PIK3CA/C7/PIK3R3/NDUFA9/APAF1/IL6/DDIT3/RYR3/CYBA/SLC25A5/HSPA1L/SDHA/NDUFB6/NCF1/NDUFA4/IL1B/COX7A2/C6	40
KEGG	hsa04012	ErbB signaling pathway	13/1141	85/8135	0.414	0.703	0.4948	PIK3R1/BTC/PRKCB/EGFR/HBEGF/PLCG2/ERBB2/PIK3CD/PIK3CA/PAK1/PIK3R3/AKT3/SHC2	13
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1141	30/8135	0.4145	0.703	0.4948	HYI/ACAT1/PCCA/MDH1/CAT	5
KEGG	hsa00920	Sulfur metabolism	2/1141	10/8135	0.4195	0.7077	0.4982	SELENBP1/BPNT1	2
KEGG	hsa00270	Cysteine and methionine metabolism	8/1141	51/8135	0.4256	0.7144	0.5029	BHMT2/CDO1/CBS/AHCYL1/DNMT1/MAT1A/AHCYL2/MDH1	8
KEGG	hsa00230	Purine metabolism	19/1141	128/8135	0.4327	0.7207	0.5073	ENPP1/AMPD3/NT5E/HDDC2/ADK/NPR2/RRM2/NME7/ADA/PDE1A/AK1/PNP/ENTPD1/ENTPD4/NME4/PDE3B/CANT1/AK6/PRPS2	19
KEGG	hsa00120	Primary bile acid biosynthesis	3/1141	17/8135	0.4337	0.7207	0.5073	ACOX2/SLC27A5/CYP46A1	3
KEGG	hsa05168	Herpes simplex virus 1 infection	71/1141	495/8135	0.4376	0.7235	0.5093	CCL5/TRAF3/PIK3R1/TAP1/TAPBP/ZNF12/IRF9/BIRC3/HLA-F/HLA-A/STAT1/TAP2/MYD88/ZNF573/HLA-C/OAS2/TLR2/CD74/BID/OAS1/HLA-G/IRF7/JAK2/CFP/IFIH1/TNFRSF14/HLA-E/ZNF510/SRPK1/HLA-DRA/HLA-DPB1/HLA-B/SRSF8/BAK1/ZNF211/ZNF331/ZNF623/NFKBIA/PIK3CD/HLA-DMA/DDX58/ZNF3/NFKB1/HLA-DMB/PTPN11/ZNF354A/IFNG/PPP1CA/PIK3CA/ZNF267/ZNF200/OAS3/SYK/IKBKG/PIK3R3/AKT3/APAF1/ZNF34/IL6/ZNF506/HLA-DPA1/ZNF667/ZNF8/TP53/ZNF415/CCL2/IFNA1/TYK2/ZSCAN32/IL1B/PML	71
KEGG	hsa04916	Melanogenesis	15/1141	101/8135	0.4484	0.7349	0.5173	KITLG/WNT5B/PRKCB/CREBBP/CREB3L2/TCF7/TCF7L2/FZD4/LEF1/FZD7/TCF7L1/EDNRB/FZD6/DVL1/FZD2	15
KEGG	hsa00562	Inositol phosphate metabolism	11/1141	73/8135	0.449	0.7349	0.5173	PLCE1/ALDH6A1/PIP4K2B/PLCG2/MTMR14/PIK3CD/INPP1/PIK3CA/INPP5D/PIP4K2A/MTMR2	11
KEGG	hsa04540	Gap junction	13/1141	88/8135	0.4662	0.755	0.5314	LPAR1/PRKCB/PDGFD/HTR2B/TUBA4A/TUBB2B/EGFR/CDK1/TUBB4A/HTR2A/MAP3K2/PRKG1/PRKG2	13
KEGG	hsa00513	Various types of N-glycan biosynthesis	6/1141	39/8135	0.4721	0.755	0.5314	MGAT4C/MAN1C1/STT3A/MAN2A2/FUT8/B4GALT2	6
KEGG	hsa00511	Other glycan degradation	3/1141	18/8135	0.4727	0.755	0.5314	FUCA1/MAN2B1/MANBA	3
KEGG	hsa04136	Autophagy - other	5/1141	32/8135	0.4727	0.755	0.5314	GABARAPL1/PPP2CA/GABARAPL2/PPP2CB/ATG3	5
KEGG	hsa04215	Apoptosis - multiple species	5/1141	32/8135	0.4727	0.755	0.5314	BIRC3/BID/BAK1/PMAIP1/APAF1	5
KEGG	hsa04022	cGMP-PKG signaling pathway	24/1141	167/8135	0.4827	0.7672	0.54	PPP3CA/NPR2/ADORA3/CREB3L2/PLN/ATP1B1/VASP/KCNJ8/SLC25A4/GTF2IRD1/AGTR1/PPP1CA/ATP1A2/SLC8A1/EDNRB/AKT3/PRKG1/MYL9/SLC25A5/PDE3B/MYLK/IRS4/PRKG2/ATP2A3	24
KEGG	hsa03420	Nucleotide excision repair	7/1141	47/8135	0.4951	0.7832	0.5513	LIG1/CETN2/RFC3/POLE2/CUL4B/ERCC1/GTF2H5	7
KEGG	hsa03410	Base excision repair	5/1141	33/8135	0.5012	0.7889	0.5553	LIG1/FEN1/PARP4/PARP1/POLE2	5
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	30/1141	212/8135	0.5096	0.7976	0.5614	PIK3R1/FGF18/EPHX1/GSTM5/PRKCB/FGF7/GSTM3/GSTA4/AR/JAK2/RPS6KA1/EGFR/FGF2/CREB3L2/PIK3CD/NFKB1/ARNT/PIK3CA/HSP90AB1/CCND1/FGF9/PIK3R3/AKT3/KPNA2/UGT2B17/RB1/GSTO1/GSTM2/EPHX3/EPHX2	30
KEGG	hsa04934	Cushing syndrome	22/1141	155/8135	0.5116	0.7976	0.5614	CDKN2C/WNT5B/EGFR/KMT2A/CREB3L2/TCF7/KCNK2/SP1/TCF7L2/PBX1/FZD4/LEF1/FZD7/AGTR1/ARNT/TCF7L1/CCND1/FZD6/RB1/DVL1/FZD2/CCNE2	22
KEGG	hsa04140	Autophagy - animal	20/1141	141/8135	0.5156	0.8002	0.5632	PIK3R1/GABARAPL1/PRKCQ/RAB8A/PPP2CA/CTSL/DEPTOR/GABARAPL2/MTMR14/RAB33B/PIK3CD/PPP2CB/RRAS/CTSB/PIK3CA/ATG3/PIK3R3/AKT3/CFLAR/IRS4	20
KEGG	hsa04150	mTOR signaling pathway	22/1141	156/8135	0.5246	0.8094	0.5697	PIK3R1/LRP6/CAB39L/IGF1/WNT5B/PRKCB/RPS6KA1/DEPTOR/LRP5/PIK3CD/SLC7A5/FZD4/FZD7/PIK3CA/EIF4B/PIK3R3/AKT3/FZD6/DVL1/PRR5L/FZD2/ATP6V1B2	22
KEGG	hsa00040	Pentose and glucuronate interconversions	5/1141	34/8135	0.529	0.8094	0.5697	AKR1B1/KL/UGDH/UGP2/UGT2B17	5
KEGG	hsa04340	Hedgehog signaling pathway	8/1141	56/8135	0.5362	0.8094	0.5697	GAS1/GLI3/CCND2/CDON/SCUBE2/SPOP/CCND1/MEGF8	8
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1141	27/8135	0.5363	0.8094	0.5697	B3GALNT1/B3GNT2/FUT4/B4GALT2	4
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/1141	27/8135	0.5363	0.8094	0.5697	HSD17B12/ELOVL4/ELOVL2/ELOVL5	4
KEGG	hsa04966	Collecting duct acid secretion	4/1141	27/8135	0.5363	0.8094	0.5697	TCIRG1/CA2/SLC12A7/ATP6V1B2	4
KEGG	hsa00100	Steroid biosynthesis	3/1141	20/8135	0.5465	0.8173	0.5753	LBR/SC5D/SOAT2	3
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1141	20/8135	0.5465	0.8173	0.5753	CHST15/CHST3/CHST11	3
KEGG	hsa04217	Necroptosis	22/1141	159/8135	0.563	0.8382	0.59	TNFAIP3/IRF9/BIRC3/STAT1/BID/TNFSF10/JAK2/STAT4/PLA2G4C/CASP1/SLC25A4/IFNG/HSP90AB1/PARP1/CHMP2B/SLC25A5/CFLAR/IFNA1/TYK2/IL1B/CHMP1B/NLRP3	22
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	5/1141	36/8135	0.5824	0.8631	0.6075	ENPP1/NT5E/SIRT7/PNP/CD38	5
KEGG	hsa00330	Arginine and proline metabolism	7/1141	51/8135	0.5862	0.8648	0.6087	LAP3/ALDH7A1/ALDH3A2/OAT/CNDP2/MAOA/MAOB	7
KEGG	hsa00600	Sphingolipid metabolism	7/1141	52/8135	0.6076	0.8888	0.6256	SGPL1/SPHK1/SGMS1/GLA/UGCG/CERK/CERS4	7
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	5/1141	37/8135	0.6078	0.8888	0.6256	ASPA/GFPT1/FOLH1/GFPT2/ALDH5A1	5
KEGG	hsa04730	Long-term depression	8/1141	60/8135	0.6183	0.8913	0.6273	IGF1/PPP2CA/PRKCB/PPP2CB/PLA2G4C/PRKG1/LYN/PRKG2	8
KEGG	hsa02010	ABC transporters	6/1141	45/8135	0.6187	0.8913	0.6273	TAP1/TAP2/ABCG1/ABCC4/ABCA8/ABCA3	6
KEGG	hsa01230	Biosynthesis of amino acids	10/1141	75/8135	0.6196	0.8913	0.6273	CBS/ALDOC/PC/IDH2/RPIA/MAT1A/PSPH/TALDO1/TKTL1/PRPS2	10
KEGG	hsa05012	Parkinson disease	36/1141	266/8135	0.6204	0.8913	0.6273	UCHL1/GNAL/NDUFC1/NDUFA4L2/UBE2L6/NDUFS2/COX7A1/SLC18A2/TUBA4A/SNCAIP/NDUFS4/TUBB2B/SLC39A8/TUBB4A/MAOA/NDUFA13/SOD1/ADRM1/SLC25A4/PINK1/NDUFA9/APAF1/SLC39A6/MAOB/DDIT3/RYR3/UBE2J1/SLC25A5/SDHA/NDUFB6/SLC39A7/TP53/NDUFA4/UBE2G2/COX7A2/TXN2	36
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1141	53/8135	0.6285	0.8967	0.6312	PRKCB/DNM1/ATP1B1/KL/ATP1A2/SLC8A1/PTH1R	7
KEGG	hsa00564	Glycerophospholipid metabolism	13/1141	98/8135	0.6307	0.8967	0.6312	PLA2G2D/LPCAT3/CHPT1/PNPLA6/PLD1/ETNK1/PLA2G12A/PLA2G4C/DGKA/PLA1A/PTDSS1/MBOAT7/GPD1L	13
KEGG	hsa00561	Glycerolipid metabolism	8/1141	61/8135	0.6376	0.8967	0.6312	GK/ALDH7A1/ALDH3A2/AKR1B1/LIPG/DGKA/GLA/LIPC	8
KEGG	hsa03050	Proteasome	6/1141	46/8135	0.6408	0.8967	0.6312	PSMB9/PSMB8/PSMB10/PSME1/ADRM1/IFNG	6
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1141	15/8135	0.643	0.8967	0.6312	B3GALNT1/GLA	2
KEGG	hsa00730	Thiamine metabolism	2/1141	15/8135	0.643	0.8967	0.6312	AK1/ALPL	2
KEGG	hsa03060	Protein export	3/1141	23/8135	0.645	0.8967	0.6312	SEC62/SEC63/SEC11A	3
KEGG	hsa04924	Renin secretion	9/1141	69/8135	0.6459	0.8967	0.6312	PPP3CA/PDE1A/KCNJ2/CTSB/AGTR1/PTGER4/PDE3B/REN/PRKG2	9
KEGG	hsa03013	Nucleocytoplasmic transport	14/1141	108/8135	0.6675	0.9201	0.6477	NUP93/XPO6/TPR/NUP160/SAP18/THOC2/PNN/IPO7/KPNA2/NUP88/THOC1/NUP50/THOC6/XPO4	14
KEGG	hsa04915	Estrogen signaling pathway	18/1141	138/8135	0.6684	0.9201	0.6477	PIK3R1/EGFR/HBEGF/KCNJ5/HSPA6/CREB3L2/SP1/PIK3CD/FKBP5/PIK3CA/HSP90AB1/KRT19/PIK3R3/AKT3/SHC2/HSPA1L/KRT10/KRT33B	18
KEGG	hsa04977	Vitamin digestion and absorption	3/1141	24/8135	0.6743	0.9243	0.6506	FOLH1/LMBRD1/SLC5A6	3
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/1141	16/8135	0.6786	0.9264	0.6521	CDO1/FMO2	2
KEGG	hsa04024	cAMP signaling pathway	29/1141	221/8135	0.6819	0.9271	0.6526	PIK3R1/RAC2/PLCE1/SOX9/NPY1R/GLI3/ABCC4/FXYD1/CREBBP/CREB3L2/PLD1/PLN/NFKBIA/PIK3CD/RRAS/NFKB1/ATP1B1/VAV1/SSTR5/PPP1CA/ATP1A2/PIK3CA/PAK1/PIK3R3/AKT3/MYL9/PDE3B/VAV3/ATP2A3	29
KEGG	hsa04972	Pancreatic secretion	13/1141	102/8135	0.6889	0.9323	0.6562	PLA2G2D/RAB8A/PRKCB/PLA2G12A/TRPC1/ATP1B1/CA2/ATP1A2/CPA3/SLC12A2/CD38/CTRB2/ATP2A3	13
KEGG	hsa04929	GnRH secretion	8/1141	64/8135	0.692	0.9323	0.6562	PIK3R1/PRKCB/KCNJ5/PIK3CD/TRPC1/PIK3CA/PIK3R3/AKT3	8
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1141	25/8135	0.7017	0.9323	0.6562	PLA2G2D/PLA2G12A/PLA2G4C	3
KEGG	hsa00565	Ether lipid metabolism	6/1141	49/8135	0.7023	0.9323	0.6562	PLA2G2D/CHPT1/PLD1/PLA2G12A/PLA2G4C/PLA2G7	6
KEGG	hsa05030	Cocaine addiction	6/1141	49/8135	0.7023	0.9323	0.6562	SLC18A2/PDYN/CREB3L2/MAOA/NFKB1/MAOB	6
KEGG	hsa04141	Protein processing in endoplasmic reticulum	22/1141	171/8135	0.7036	0.9323	0.6562	SKP1/SEC62/CRYAB/HSPA6/SEC31A/BAG2/BAK1/HSPA4L/EDEM1/UBE2D1/VCP/SEC63/HSP90AB1/MAN1C1/DDIT3/UBE2J1/MBTPS2/STT3A/HSPA1L/EDEM2/SEC23B/UBE2G2	22
KEGG	hsa04512	ECM-receptor interaction	11/1141	88/8135	0.7065	0.9323	0.6562	ITGB7/ITGA4/HMMR/LAMA2/CD36/COMP/DAG1/THBS4/ITGA10/GP1BA/ITGAV	11
KEGG	hsa04270	Vascular smooth muscle contraction	17/1141	134/8135	0.7107	0.9323	0.6562	PLA2G2D/PRKCH/MYH10/PRKCQ/PRKCB/NPR2/CALD1/PLA2G12A/PLA2G4C/ARHGEF12/AGTR1/PPP1CA/PRKG1/MYH11/MYL9/MYLK/MYL6B	17
KEGG	hsa00910	Nitrogen metabolism	2/1141	17/8135	0.7112	0.9323	0.6562	CA14/CA2	2
KEGG	hsa05110	Vibrio cholerae infection	6/1141	50/8135	0.7211	0.9415	0.6627	TCIRG1/PLCG2/KDELR3/SLC12A2/KDELR2/ATP6V1B2	6
KEGG	hsa04146	Peroxisome	10/1141	82/8135	0.7312	0.9509	0.6693	ACOX2/PEX26/PMVK/IDH2/SOD1/ECI2/PEX19/CAT/ACSL5/EPHX2	10
KEGG	hsa00860	Porphyrin metabolism	5/1141	43/8135	0.7401	0.9524	0.6704	CP/ALAS1/UGT2B17/HMBS/ALAD	5
KEGG	hsa00010	Glycolysis / Gluconeogenesis	8/1141	67/8135	0.7409	0.9524	0.6704	ALDH7A1/ALDH3A2/ADH1C/HK3/ALDOC/PCK1/ADH1B/ADH5	8
KEGG	hsa00061	Fatty acid biosynthesis	2/1141	18/8135	0.7411	0.9524	0.6704	ACACB/ACSL5	2
KEGG	hsa04922	Glucagon signaling pathway	13/1141	107/8135	0.7536	0.9647	0.679	PPP3CA/CREBBP/PHKB/CREB3L2/SIK1/PCK1/ACACB/PPP4C/FOXO1/AKT3/PDE3B/PRMT1/PRKAB1	13
KEGG	hsa04371	Apelin signaling pathway	17/1141	139/8135	0.7657	0.9712	0.6836	GNG12/HDAC4/SPHK1/PLAT/RRAS/SMAD3/AGTR1/PLIN1/SLC8A1/CCND1/APLNR/AKT3/TFAM/RYR3/PDE3B/MYLK/PRKAB1	17
KEGG	hsa00531	Glycosaminoglycan degradation	2/1141	19/8135	0.7682	0.9712	0.6836	HYAL1/IDUA	2
KEGG	hsa05031	Amphetamine addiction	8/1141	69/8135	0.7704	0.9712	0.6836	PPP3CA/PRKCB/SLC18A2/PDYN/CREB3L2/MAOA/PPP1CA/MAOB	8
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	8/1141	69/8135	0.7704	0.9712	0.6836	EPHX1/GSTM5/GSTM3/GSTA4/HPGDS/UGT2B17/GSTO1/GSTM2	8
KEGG	hsa03022	Basal transcription factors	5/1141	45/8135	0.7761	0.9745	0.686	TAF7/GTF2F1/GTF2IRD1/GTF2A1/GTF2H5	5
KEGG	hsa05010	Alzheimer disease	49/1141	384/8135	0.7885	0.9856	0.6938	PIK3R1/LRP6/WNT5B/NDUFC1/NDUFA4L2/PPP3CA/BID/NDUFS2/COX7A1/TUBA4A/NDUFS4/TUBB2B/SLC39A8/TUBB4A/LRP5/NOX4/PIK3CD/NDUFA13/NFKB1/FZD4/ADRM1/FZD7/SLC25A4/PIK3CA/IKBKG/BACE1/PIK3R3/AKT3/NDUFA9/APAF1/SLC39A6/IL6/FZD6/DDIT3/RYR3/ADAM10/SLC25A5/SDHA/DVL1/NDUFB6/NAE1/SLC39A7/IRS4/FZD2/FRAT1/NDUFA4/IL1B/COX7A2/ATP2A3	49
KEGG	hsa00670	One carbon pool by folate	2/1141	20/8135	0.7928	0.9856	0.6938	MTHFD2/TYMS	2
KEGG	hsa00591	Linoleic acid metabolism	3/1141	29/8135	0.7939	0.9856	0.6938	PLA2G2D/PLA2G12A/PLA2G4C	3
KEGG	hsa05017	Spinocerebellar ataxia	17/1141	143/8135	0.8044	0.9949	0.7003	PIK3R1/PRKCB/PDYN/SP1/AFG3L2/PIK3CD/ADRM1/SLC25A4/PIK3CA/NFYA/FGF14/PIK3R3/AKT3/SLC25A5/ATXN2/ATXN10/ATP2A3	17
KEGG	hsa04137	Mitophagy - animal	8/1141	72/8135	0.81	0.9981	0.7025	GABARAPL1/GABARAPL2/SP1/RRAS/PINK1/FOXO3/TP53/BNIP3L	8
KEGG	hsa00770	Pantothenate and CoA biosynthesis	2/1141	21/8135	0.8151	1	0.7039	ENPP1/ALDH3A2	2
KEGG	hsa04926	Relaxin signaling pathway	15/1141	129/8135	0.8197	1	0.7039	PIK3R1/GNG12/MMP1/EGFR/CREB3L2/NFKBIA/PIK3CD/MAPK13/NFKB1/PIK3CA/EDNRB/PIK3R3/AKT3/VEGFB/SHC2	15
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	12/1141	106/8135	0.8279	1	0.7039	LRP6/PTHLH/PRKCB/EGFR/HBEGF/CREB3L2/SP1/PLD1/LRP5/KL/AKAP13/PTH1R	12
KEGG	hsa04728	Dopaminergic synapse	15/1141	132/8135	0.8453	1	0.7039	GNG12/GNAL/PPP2CA/PPP3CA/PRKCB/SLC18A2/KCNJ5/CREB3L2/MAOA/MAPK13/PPP2CB/ARNTL/PPP1CA/AKT3/MAOB	15
KEGG	hsa00515	Mannose type O-glycan biosynthesis	2/1141	23/8135	0.8534	1	0.7039	FUT4/B4GALT2	2
KEGG	hsa03430	Mismatch repair	2/1141	23/8135	0.8534	1	0.7039	LIG1/RFC3	2
KEGG	hsa04971	Gastric acid secretion	8/1141	76/8135	0.8544	1	0.7039	PRKCB/KCNK2/KCNJ15/KCNJ2/ATP1B1/CA2/ATP1A2/MYLK	8
KEGG	hsa04970	Salivary secretion	10/1141	93/8135	0.8581	1	0.7039	PRKCB/LYZ/ATP1B1/ATP1A2/SLC12A2/VAMP2/CD38/PRKG1/RYR3/PRKG2	10
KEGG	hsa00830	Retinol metabolism	7/1141	68/8135	0.8587	1	0.7039	ADH1C/DHRS3/ADH1B/ADH5/DHRS9/UGT2B17/RETSAT	7
KEGG	hsa03450	Non-homologous end-joining	1/1141	13/8135	0.86	1	0.7039	FEN1	1
KEGG	hsa04120	Ubiquitin mediated proteolysis	16/1141	142/8135	0.8606	1	0.7039	BIRC3/SKP1/UBE2L6/UBE2C/SOCS1/UBE2B/UBE2Z/UBE2D1/KLHL9/CUL2/UBE2J1/CDC20/CUL4B/UBE2E3/UBE2G2/PML	16
KEGG	hsa00051	Fructose and mannose metabolism	3/1141	33/8135	0.861	1	0.7039	AKR1B1/HK3/ALDOC	3
KEGG	hsa04978	Mineral absorption	6/1141	60/8135	0.8645	1	0.7039	CYBRD1/ATP1B1/ATP1A2/SLC8A1/TRPM6/MT1X	6
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1141	24/8135	0.8696	1	0.7039	EXTL2/EXT2	2
KEGG	hsa04975	Fat digestion and absorption	4/1141	43/8135	0.8717	1	0.7039	PLA2G2D/CD36/ACAT1/PLA2G12A	4
KEGG	hsa05322	Systemic lupus erythematosus	15/1141	136/8135	0.875	1	0.7039	CD40/HLA-DRA/HLA-DPB1/CD40LG/HLA-DMA/CD86/TRIM21/HLA-DMB/IFNG/C7/CD80/SNRPB/HLA-DPA1/FCGR3B/C6	15
KEGG	hsa04921	Oxytocin signaling pathway	17/1141	154/8135	0.8867	1	0.7039	CACNA2D1/PPP3CA/PRKCB/NPR2/EGFR/KCNJ5/CAMK1D/KCNJ2/PLA2G4C/PPP1CA/CCND1/CD38/RYR3/MYL9/MYLK/MYL6B/PRKAB1	17
KEGG	hsa03460	Fanconi anemia pathway	5/1141	54/8135	0.8923	1	0.7039	FANCI/BLM/REV3L/RMI1/ERCC1	5
KEGG	hsa00500	Starch and sucrose metabolism	3/1141	36/8135	0.898	1	0.7039	ENPP1/HK3/UGP2	3
KEGG	hsa04726	Serotonergic synapse	12/1141	115/8135	0.8988	1	0.7039	GNG12/PRKCB/SLC18A2/HTR2B/KCNJ5/MAOA/PLA2G4C/TRPC1/HTR2A/PTGS1/MAOB/ALOX5	12
KEGG	hsa00514	Other types of O-glycan biosynthesis	4/1141	47/8135	0.9119	1	0.7039	COLGALT2/GALNT11/GALNT10/B4GALT2	4
KEGG	hsa00190	Oxidative phosphorylation	14/1141	134/8135	0.9124	1	0.7039	NDUFC1/NDUFA4L2/TCIRG1/NDUFS2/COX7A1/NDUFS4/COX11/NDUFA13/NDUFA9/SDHA/NDUFB6/ATP6V1B2/NDUFA4/COX7A2	14
KEGG	hsa04974	Protein digestion and absorption	10/1141	103/8135	0.9271	1	0.7039	COL8A2/COL8A1/COL14A1/ATP1B1/COL15A1/ATP1A2/SLC8A1/CPA3/CTRB2/COL16A1	10
KEGG	hsa04330	Notch signaling pathway	5/1141	59/8135	0.931	1	0.7039	CREBBP/NOTCH1/HEY2/HEY1/DVL1	5
KEGG	hsa05014	Amyotrophic lateral sclerosis	42/1141	364/8135	0.9329	1	0.7039	TNFRSF1B/NDUFC1/NDUFA4L2/RAB8A/PPP3CA/BID/PFN2/SIGMAR1/NDUFS2/COX7A1/NUP93/TUBA4A/NDUFS4/TUBB2B/TPR/TUBB4A/NDUFA13/NUP160/SOD1/MAPK13/GPX3/CASP1/ADRM1/VCP/DCTN6/PINK1/NDUFA9/APAF1/CHMP2B/DDIT3/ANG/NUP88/SDHA/NDUFB6/CAT/ATXN2/NUP50/PFN1/TP53/HNRNPA3/NDUFA4/COX7A2	42
KEGG	hsa04721	Synaptic vesicle cycle	7/1141	78/8135	0.9347	1	0.7039	TCIRG1/SLC18A2/DNM1/SLC1A3/VAMP2/STXBP1/ATP6V1B2	7
KEGG	hsa04260	Cardiac muscle contraction	8/1141	87/8135	0.9349	1	0.7039	CACNA2D1/COX7A1/ASPH/ATP1B1/ATP1A2/SLC8A1/COX7A2/ATP2A3	8
KEGG	hsa03018	RNA degradation	7/1141	79/8135	0.9398	1	0.7039	TOB1/DDX6/LSM3/TOB2/EXOSC7/LSM5/PARN	7
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	56/1141	476/8135	0.9399	1	0.7039	UCHL1/LRP6/WNT5B/TNFRSF1B/NDUFC1/NDUFA4L2/RAB8A/PPP3CA/PRKCB/BID/UBE2L6/SIGMAR1/NDUFS2/COX7A1/TUBA4A/SNCAIP/NDUFS4/TUBB2B/PDYN/BAK1/TUBB4A/LRP5/NOX4/NDUFA13/SOD1/MAPK13/NFKB1/GPX3/FZD4/ADRM1/FZD7/VCP/SLC25A4/DCTN6/PINK1/NDUFA9/APAF1/IL6/FZD6/CHMP2B/DDIT3/RYR3/UBE2J1/SLC25A5/SDHA/DVL1/NDUFB6/CAT/ATXN2/FZD2/FRAT1/NDUFA4/IL1B/UBE2G2/COX7A2/ATP2A3	56
KEGG	hsa03440	Homologous recombination	3/1141	41/8135	0.9403	1	0.7039	BLM/BARD1/TOPBP1	3
KEGG	hsa04913	Ovarian steroidogenesis	4/1141	51/8135	0.9405	1	0.7039	IGF1/AKR1C3/PLA2G4C/ALOX5	4
KEGG	hsa00140	Steroid hormone biosynthesis	5/1141	61/8135	0.9426	1	0.7039	AKR1C3/STS/AKR1C1/HSD17B12/UGT2B17	5
KEGG	hsa04714	Thermogenesis	25/1141	232/8135	0.9426	1	0.7039	NDUFC1/NDUFA4L2/NDUFS2/COX7A1/RPS6KA1/NDUFS4/SMARCD3/CREB3L2/COX11/NDUFA13/MAPK13/SMARCC2/SMARCA2/NDUFAF3/PLIN1/SMARCD1/NDUFA9/PRKG1/SDHA/NDUFB6/PRKAB1/ACSL5/NDUFA4/COX7A2/PRKG2	25
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/1141	19/8135	0.9436	1	0.7039	IDH2	1
KEGG	hsa04976	Bile secretion	8/1141	89/8135	0.9443	1	0.7039	EPHX1/ABCC4/AQP9/ATP1B1/CA2/ATP1A2/UGT2B17/SLC27A5	8
KEGG	hsa04925	Aldosterone synthesis and secretion	9/1141	98/8135	0.9446	1	0.7039	PRKCB/PRKD2/KCNJ5/CREB3L2/CAMK1D/ATP1B1/AGTR1/ATP1A2/PRKD1	9
KEGG	hsa04927	Cortisol synthesis and secretion	5/1141	65/8135	0.9607	1	0.7039	CREB3L2/KCNK2/SP1/PBX1/AGTR1	5
KEGG	hsa04918	Thyroid hormone synthesis	6/1141	75/8135	0.962	1	0.7039	PRKCB/TTF1/CREB3L2/GPX3/ATP1B1/ATP1A2	6
KEGG	hsa04725	Cholinergic synapse	10/1141	113/8135	0.9651	1	0.7039	PIK3R1/GNG12/PRKCB/JAK2/CREB3L2/PIK3CD/KCNJ2/PIK3CA/PIK3R3/AKT3	10
KEGG	hsa04720	Long-term potentiation	5/1141	67/8135	0.9676	1	0.7039	PPP3CA/PRKCB/RPS6KA1/CREBBP/PPP1CA	5
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	14/1141	150/8135	0.9688	1	0.7039	CACNA2D1/PPP2CA/CREB3L2/PLN/MAPK13/PPP2CB/ATP1B1/SCN1B/AGTR1/PPP1CA/ATP1A2/SLC8A1/AKT3/ATP2A3	14
KEGG	hsa00512	Mucin type O-glycan biosynthesis	2/1141	36/8135	0.9704	1	0.7039	GALNT11/GALNT10	2
KEGG	hsa03015	mRNA surveillance pathway	8/1141	97/8135	0.9711	1	0.7039	PPP2CA/CPSF6/CSTF2/PPP2CB/SAP18/PPP1CA/PNN/CLP1	8
KEGG	hsa04713	Circadian entrainment	8/1141	97/8135	0.9711	1	0.7039	GNG12/PRKCB/KCNJ5/PER2/PRKG1/PER3/RYR3/PRKG2	8
KEGG	hsa04723	Retrograde endocannabinoid signaling	13/1141	148/8135	0.981	1	0.7039	GNG12/NDUFC1/NDUFA4L2/PRKCB/NDUFS2/NDUFS4/KCNJ5/NDUFA13/MAPK13/NDUFA9/ABHD6/NDUFB6/NDUFA4	13
KEGG	hsa04912	GnRH signaling pathway	7/1141	93/8135	0.9823	1	0.7039	PRKCB/EGFR/HBEGF/PLD1/MAPK13/PLA2G4C/MAP3K2	7
KEGG	hsa04744	Phototransduction	1/1141	29/8135	0.9876	1	0.7039	GUCA1A	1
KEGG	hsa05206	MicroRNAs in cancer	31/1141	310/8135	0.9876	1	0.7039	PIK3R1/TIMP3/PIM1/CCND2/PRKCB/ZFPM2/HDAC4/SOCS1/EGFR/RECK/CREBBP/CDC25B/PLCG2/ERBB2/BAK1/EZH2/PIK3CD/TP63/BCL2L2/NFKB1/DNMT1/EFNA5/NOTCH1/PIK3CA/CCND1/HOXD10/PIK3R3/CCNG1/TP53/CCNE2/KIF23	31
KEGG	hsa05032	Morphine addiction	6/1141	91/8135	0.9918	1	0.7039	GNG12/GRK6/PRKCB/KCNJ5/PDE1A/PDE3B	6
KEGG	hsa03020	RNA polymerase	1/1141	34/8135	0.9942	1	0.7039	POLR2L	1
KEGG	hsa05016	Huntington disease	29/1141	306/8135	0.9943	1	0.7039	NDUFC1/NDUFA4L2/NDUFS2/COX7A1/TUBA4A/NDUFS4/TUBB2B/CREBBP/SLC1A3/CREB3L2/SP1/TUBB4A/NDUFA13/SOD1/GPX3/ADRM1/SLC25A4/POLR2L/DCTN6/NDUFA9/APAF1/TFAM/SLC25A5/SDHA/NDUFB6/TGM2/TP53/NDUFA4/COX7A2	29
KEGG	hsa03040	Spliceosome	11/1141	147/8135	0.9954	1	0.7039	HSPA6/SRSF8/DHX8/THOC2/SNRPB/HSPA1L/SYF2/LSM3/THOC1/HNRNPA3/LSM5	11
KEGG	hsa04911	Insulin secretion	5/1141	86/8135	0.9955	1	0.7039	PRKCB/CREB3L2/ATP1B1/ATP1A2/VAMP2	5
KEGG	hsa04080	Neuroactive ligand-receptor interaction	34/1141	353/8135	0.9956	1	0.7039	GZMA/PENK/NPY1R/PARD3/LPAR1/GLRB/HTR2B/PDYN/TAC1/ADORA3/NMB/GHR/HTR2A/CHRNA5/HRH1/LEP/FPR1/SSTR5/AGTR1/PTGFR/PRL/PTGER4/P2RY6/APLNR/EDNRB/HCRTR1/FPR2/P2RY14/S1PR1/PTH1R/VIPR1/S1PR4/P2RY4/THRA	34
KEGG	hsa04727	GABAergic synapse	5/1141	89/8135	0.9967	1	0.7039	GNG12/GABARAPL1/PRKCB/TRAK2/GABARAPL2	5
KEGG	hsa04724	Glutamatergic synapse	7/1141	114/8135	0.9977	1	0.7039	GNG12/PPP3CA/PRKCB/SLC1A3/PLD1/PLA2G4C/TRPC1	7
KEGG	hsa03010	Ribosome	11/1141	158/8135	0.9983	1	0.7039	RPL31/RPL24/RPS4X/RPL12/RSL24D1/MRPL15/MRPS14/RPL15/RPL10A/RPS14/MRPL20	11
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	5/1141	109/8135	0.9997	1	0.7039	REXO2/RPP38/AK6/WDR43/UTP18	5
KEGG	hsa05034	Alcoholism	12/1141	187/8135	0.9997	1	0.7039	GNG12/NTRK2/HDAC4/SLC18A2/SLC29A1/PDYN/CREB3L2/MAOA/PPP1CA/MAOB/SLC29A2/SHC2	12
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	1/1141	66/8135	1	1	0.7039	WARS2	1
KEGG	hsa04742	Taste transduction	2/1141	86/8135	1	1	0.7039	PDE1A/P2RY4	2
KEGG	hsa04740	Olfactory transduction	10/1141	440/8135	1	1	0.7039	GNAL/PDE1A/OR7C2/OR51E2/SLC8A1/OR11A1/PRKG1/OR1D5/OR7E24/PRKG2	10