ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05016	Huntington disease	156/2550	306/8135	2.697e-13	9.008e-11	6.842e-11	NDUFS1/PSMB6/COX7A2L/SLC25A6/NDUFS3/UQCRFS1/POLR2F/BAX/PSMD4/PSMD8/POLR2J/CREB1/HIP1/COX1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/NDUFB8/DNAL4/BECN1/POLR2G/UQCRQ/NDUFB2/ACTR1B/ULK1/NDUFB10/COX5A/ATG13/NDUFB9/PSMA7/NDUFB11/COX6B1/NDUFA8/COX5B/DCTN3/NDUFAB1/NDUFB7/NDUFA13/NDUFA2/NDUFA7/MAPK8/POLR2H/PSMC3/UQCR10/NDUFS6/PSMD13/VDAC2/ATP6/CYC1/NDUFB1/PSMA2/POLR2I/PSMD9/SOD2/SLC25A5/RB1CC1/NDUFS7/UQCR11/PSMC4/KIF5B/ITPR1/CREBBP/GRIN1/POLR2B/NDUFA9/NDUFA1/NDUFA3/PSMA1/PSMD12/TFAM/PSMB1/PSMD2/NDUFB5/ATG2A/CREB3/COX6A1/PSMD1/NDUFS2/IFT57/PSMB3/NDUFB3/TBP/ATG2B/CACNA1B/NDUFB4/POLR2L/NDUFV3/REST/CREB3L4/PSMD14/PSMC6/NDUFA4/SDHB/NDUFA12/NDUFA6/DCTN6/DCTN5/PSMB5/POLR2E/CREB3L2/AP2B1/PSMA4/PSMA3/NDUFA4L2/NDUFA10/DNAH7/MAPK9/AP2S1/ATG14/NDUFS4/PSMB4/POLR2D/COX7B/UQCRC2/MTOR/PSMC2/NDUFC1/CASP8/PIK3C3/TUBA1B/PPARGC1A/VDAC3/CLTA/COX7C/KLC2/TUBB1/SDHA/ACTR10/SDHD/COX4I1/HDAC1/POLR2C/PSMD6/TAF4B/GPX2/NDUFV1/CLTC/ULK2/HTT/KIF5A/TGM2/AP2A2/CLTB/DNAH5/COX8C/TUBA4A/PSMA5/HDAC2/SOD1/SIN3A/MAP2K7	156
KEGG	hsa05014	Amyotrophic lateral sclerosis	173/2550	364/8135	3.085e-11	5.151e-09	3.912e-09	NDUFS1/PSMB6/HNRNPA2B1/COX7A2L/NDUFS3/UQCRFS1/BAX/PSMD4/PSMD8/COX1/HNRNPA1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/ALYREF/NDUFB8/DNAL4/BECN1/UQCRQ/NDUFB2/ACTR1B/ULK1/MAP2K6/NDUFB10/COX5A/NUP153/NUP107/ATG13/NXF1/NDUFB9/PSMA7/NDUFB11/CHCHD10/COX6B1/NDUFA8/VCP/COX5B/DCTN3/POM121C/ATF6/NUP155/NDUFAB1/NDUFB7/CCS/NDUFA13/SMCR8/MAPK11/NDUFA2/NDUFA7/MCU/PSMC3/UQCR10/NDUFS6/UBQLN4/PSMD13/ATP6/SEH1L/CYC1/NDUFB1/PSMA2/PSMD9/SEC13/PINK1/RB1CC1/NDUFS7/UQCR11/NEFH/PSMC4/NUP205/KIF5B/GRIN1/NDUFA9/ANXA11/NDUFA1/NDUFA3/PSMA1/PSMD12/PSMB1/PSMD2/NDUFB5/NUP98/ATG2A/COX6A1/ATXN2L/PSMD1/NDUFS2/PSMB3/NCBP1/NDUFB3/ATG2B/NUP188/NDUFB4/NDUFV3/HNRNPA3/NUP62/NUP93/NUP50/PSMD14/BAD/PSMC6/NDUFA4/SDHB/EIF2AK3/SPG11/TNFRSF1B/NDUFA12/NDUFA6/NUP43/RANBP2/DCTN6/DCTN5/ITPR3/TBK1/PSMB5/NUP133/TARDBP/PSMA4/PSMA3/NDUFA4L2/NDUFA10/DNAH7/CAT/ATG14/NDUFS4/NUP85/NUP35/PSMB4/NUP160/COX7B/NOS1/FIG4/UQCRC2/MTOR/PSMC2/GLE1/POM121/NDUFC1/PIK3C3/TUBA1B/PFN1/COX7C/KLC2/TUBB1/SDHA/ACTR10/SDHD/COX4I1/MAPK13/TANK/TOMM40L/SRSF3/XBP1/PSMD6/GPX2/NDUFV1/ULK2/KIF5A/NUP37/DNAH5/NXT1/WDR41/COX8C/MATR3/TUBA4A/PSMA5/MAP1LC3B2/PPP3R1/SOD1	173
KEGG	hsa04714	Thermogenesis	118/2550	232/8135	2.851e-10	3.174e-08	2.411e-08	NDUFS1/SMARCA2/KDM3B/COX7A2L/GRB2/SMARCD2/NDUFS3/UQCRFS1/CREB1/COX1/COX8A/SDHC/NDUFA11/ND2/ND4/NDUFB8/ARID1A/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/NDUFB11/COX6B1/COX17/KRAS/PRKAG1/NDUFA8/NDUFAF2/COX5B/NDUFAB1/NDUFB7/COX15/NDUFA13/MAPK11/NDUFA2/NDUFA7/UQCR10/NDUFS6/ATP6/CYC1/NDUFB1/TSC1/SMARCC1/PRKAA1/RPS6KB1/NDUFS7/UQCR11/COX14/PRKACA/NDUFA9/GNAS/KDM3A/NDUFA1/NDUFA3/NDUFB5/NDUFAF5/CREB3/RPS6/COX6A1/NDUFS2/NDUFB3/NDUFB4/NDUFV3/CPT2/CREB3L4/NDUFA4/SDHB/COA3/ADCY4/SOS2/NDUFAF1/COA6/PRKACB/ACSL3/ATF2/NDUFA12/NDUFA6/RPS6KA1/CREB3L2/COX16/NDUFA4L2/SMARCA4/NDUFA10/COA4/COX19/NDUFS4/COX10/COX11/RPS6KA2/SMARCC2/ARID1B/COX7B/SMARCD1/UQCRC2/MTOR/RPS6KB2/NDUFAF3/NDUFC1/PPARGC1A/COA7/COX7C/COX20/SDHA/SDHD/COX4I1/MAPK13/SLC25A20/DPF1/ACSL5/ACSL1/LIPE/NDUFV1/HRAS/ADCY8/COX8C/NPPB/CNR1	118
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	113/2550	223/8135	9.121e-10	7.616e-08	5.785e-08	NDUFS1/COX7A2L/SLC25A6/GRB2/NDUFS3/UQCRFS1/COX1/COX8A/SDHC/NDUFA11/ND2/ND4/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/NDUFB11/ARAF/COX6B1/KRAS/NDUFA8/COX5B/KEAP1/NDUFAB1/NDUFB7/NDUFA13/MAPK11/NDUFA2/NDUFA7/MAPK8/UQCR10/RAF1/NDUFS6/VDAC2/ATP6/CYC1/MAPK3/NDUFB1/SOD2/SLC25A5/NDUFS7/UQCR11/RELA/BRAF/NDUFA9/NDUFA1/NDUFA3/NDUFB5/CHUK/CBR1/IKBKB/GSTM5/COX6A1/NDUFS2/NDUFB3/NDUFB4/NDUFV3/AKR1A1/NFE2L2/MAP2K4/BAD/NDUFA4/SDHB/HIF1A/SOS2/ACP1/NDUFA12/NDUFA6/IKBKG/PLD2/PDPK1/NDUFA4L2/NDUFA10/NQO1/MAP2K2/MAPK9/NFKB1/CAT/PIK3CA/SLC26A6/NDUFS4/PTK2/MAPK1/COX7B/UQCRC2/MGST2/NDUFC1/VDAC3/COX7C/VEGFA/ABL1/SDHA/SDHD/COX4I1/MAPK13/CYP1B1/GSTA4/AKT1/FOXO3/NDUFV1/EGF/SLC26A9/HRAS/GSTT2/COX8C/PRKD3/PIK3R2/ABL2/HGF/SOD1/MAP2K7	113
KEGG	hsa05010	Alzheimer disease	174/2550	384/8135	2.939e-09	1.964e-07	1.491e-07	NDUFS1/PSMB6/COX7A2L/SLC39A7/SLC25A6/NDUFS3/UQCRFS1/PSMD4/PSMD8/CALM1/COX1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/NDUFB8/BECN1/UQCRQ/NDUFB2/ULK1/NDUFB10/COX5A/ATG13/HSD17B10/NDUFB9/PSMA7/NDUFB11/ARAF/COX6B1/DVL3/KRAS/CSNK2A1/NDUFA8/COX5B/ATF6/NDUFAB1/NDUFB7/BACE1/NDUFA13/NDUFA2/NDUFA7/MCU/MAPK8/PSMC3/UQCR10/RAF1/NDUFS6/PSMD13/VDAC2/ATP6/CYC1/MAPK3/NDUFB1/PSMA2/PSMD9/FZD6/SLC25A5/FAS/RB1CC1/NDUFS7/UQCR11/FZD2/RELA/PSMC4/KIF5B/ITPR1/BRAF/GRIN1/NDUFA9/NDUFA1/NDUFA3/PSMA1/PSMD12/PSMB1/PSMD2/NDUFB5/CHUK/ADAM10/PSENEN/ATG2A/IKBKB/LRP6/COX6A1/APH1A/PSMD1/NDUFS2/PSMB3/NDUFB3/ATG2B/NDUFB4/CSNK1A1/SLC39A1/NDUFV3/FADD/SLC39A10/PSMD14/BAD/PSMC6/NDUFA4/SDHB/EIF2AK3/FZD1/NDUFA12/NDUFA6/SLC39A4/IKBKG/ITPR3/PSMB5/CTNNB1/CDK5/FRAT2/PSMA4/PSMA3/NDUFA4L2/NDUFA10/WNT8B/MAP2K2/MAPK9/NFKB1/PIK3CA/ATG14/NDUFS4/PSMB4/MAPK1/CSNK1E/PTGS2/COX7B/NOS1/UQCRC2/MTOR/DVL2/PSMC2/INSR/CSNK2B/WNT2B/NDUFC1/CASP8/PIK3C3/TUBA1B/APBB1/VDAC3/COX7C/WNT11/GAPDH/ATP2A2/KLC2/TUBB1/SDHA/SDHD/COX4I1/WNT1/AKT1/RTN3/IDE/XBP1/PSMD6/NDUFV1/RTN4/CAPN1/ULK2/KIF5A/HRAS/SLC39A11/COX8C/TUBA4A/PSMA5/PIK3R2/FZD9/PPP3R1/MAP2K7	174
KEGG	hsa05012	Parkinson disease	128/2550	266/8135	4.801e-09	2.673e-07	2.03e-07	NDUFS1/PSMB6/COX7A2L/SLC39A7/SLC25A6/NDUFS3/UQCRFS1/BAX/PSMD4/PSMD8/UBE2G2/CALM1/TXN2/COX1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/PSMA7/NDUFB11/COX6B1/NDUFA8/COX5B/GNAI2/KEAP1/ATF6/NDUFAB1/NDUFB7/NDUFA13/NDUFA2/NDUFA7/MCU/MAPK8/PSMC3/UQCR10/NDUFS6/PSMD13/VDAC2/ATP6/CYC1/NDUFB1/PSMA2/PSMD9/PINK1/SLC25A5/NDUFS7/UQCR11/PSMC4/KIF5B/ITPR1/PARK7/MFN1/PRKACA/NDUFA9/GNAS/NDUFA1/NDUFA3/PSMA1/PSMD12/PSMB1/PSMD2/NDUFB5/COX6A1/PSMD1/NDUFS2/PSMB3/NDUFB3/NDUFB4/SLC39A1/NDUFV3/CAMK2D/SLC39A10/NFE2L2/UBE2L3/PSMD14/PSMC6/NDUFA4/SDHB/EIF2AK3/PRKACB/NDUFA12/NDUFA6/SLC39A4/ITPR3/PSMB5/UBA52/PSMA4/PSMA3/NDUFA4L2/NDUFA10/UBE2L6/MAPK9/NDUFS4/PSMB4/COX7B/GNAI1/UQCRC2/UBC/PSMC2/NDUFC1/TUBA1B/VDAC3/SLC6A3/COX7C/KLC2/TUBB1/SDHA/SDHD/COX4I1/XBP1/PSMD6/NDUFV1/KIF5A/SLC39A11/COX8C/TUBA4A/PSMA5/SOD1	128
KEGG	hsa04932	Non-alcoholic fatty liver disease	83/2550	155/8135	6.052e-09	2.888e-07	2.193e-07	NDUFS1/IL6R/COX7A2L/NDUFS3/UQCRFS1/BAX/COX1/COX8A/SDHC/NDUFA11/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/NDUFB11/COX6B1/PRKAG1/NDUFA8/COX5B/NDUFAB1/NDUFB7/NDUFA13/MAPK11/NDUFA2/NDUFA7/MAPK8/UQCR10/NDUFS6/CYC1/NDUFB1/PRKAA1/FAS/NDUFS7/UQCR11/ADIPOR1/RELA/NDUFA9/NDUFA1/NDUFA3/NDUFB5/IKBKB/PPARA/COX6A1/CDC42/NDUFS2/NDUFB3/NDUFB4/NDUFV3/MAP3K11/NDUFA4/SDHB/EIF2AK3/SREBF1/NDUFA12/NDUFA6/NR1H3/NDUFA4L2/NDUFA10/LEPR/MAPK9/NFKB1/PIK3CA/NDUFS4/COX7B/UQCRC2/RXRA/INSR/NDUFC1/CASP8/COX7C/CEBPA/SDHA/SDHD/COX4I1/MAPK13/AKT1/XBP1/NDUFV1/SOCS3/COX8C/PIK3R2	83
KEGG	hsa05020	Prion disease	130/2550	273/8135	8.243e-09	3.441e-07	2.614e-07	NDUFS1/PSMB6/COX7A2L/SLC25A6/NDUFS3/UQCRFS1/BAX/PSMD4/PSMD8/CREB1/COX1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/PSMA7/NDUFB11/COX6B1/CSNK2A1/NDUFA8/COX5B/NDUFAB1/NDUFB7/NDUFA13/MAPK11/NDUFA2/NDUFA7/MCU/MAPK8/PSMC3/UQCR10/NDUFS6/PSMD13/VDAC2/ATP6/CYC1/MAPK3/NDUFB1/PSMA2/PSMD9/SLC25A5/NDUFS7/UQCR11/PSMC4/KIF5B/ITPR1/GRIN1/GRIN3B/PRKACA/NDUFA9/NDUFA1/NDUFA3/PSMA1/PSMD12/PSMB1/PSMD2/NDUFB5/CREB3/COX6A1/PSMD1/NDUFS2/PSMB3/C9/NDUFB3/CACNA1B/NDUFB4/NDUFV3/CREB3L4/PSMD14/BAD/PSMC6/NDUFA4/SDHB/EIF2AK3/PRKACB/HSPA1L/ATF2/NDUFA12/NDUFA6/ITPR3/FYN/PSMB5/CREB3L2/PSMA4/PSMA3/NDUFA4L2/NDUFA10/C6/MAPK9/PIK3CA/C1QA/NDUFS4/PSMB4/RYR2/MAPK1/COX7B/UQCRC2/PSMC2/CSNK2B/NDUFC1/TUBA1B/RAC2/VDAC3/COX7C/KLC2/TUBB1/SDHA/SDHD/COX4I1/MAPK13/PSMD6/NDUFV1/KIF5A/COX8C/TUBA4A/PSMA5/PIK3R2/PPP3R1/EGR1/SOD1	130
KEGG	hsa03040	Spliceosome	79/2550	147/8135	1.135e-08	4.213e-07	3.2e-07	PRPF6/PRPF3/PRPF19/DHX15/SF3B5/PQBP1/SRSF1/HNRNPA1/THOC1/ALYREF/SNRPD3/LSM2/TRA2B/SRSF4/SNRPC/SNRPF/CRNKL1/SF3B6/ISY1/SF3B1/LSM4/TXNL4A/PPIH/SNRPE/LSM6/U2AF2/SART1/DHX38/SNRPD2/DDX42/CWC15/NCBP1/CDC5L/SLU7/WBP11/NCBP2/ACIN1/TCERG1/BCAS2/SNRPD1/HNRNPA3/LSM7/LSM8/PUF60/HNRNPC/PRPF38B/DDX23/HSPA1L/U2AF1/SRSF10/EIF4A3/RBM17/RBM22/RP9/PRPF38A/AQR/SRSF6/PRPF40A/SNRPA/PRPF8/HNRNPK/PHF5A/CCDC12/HNRNPU/SMNDC1/BUD31/U2SURP/SNRNP200/CTNNBL1/DHX16/RBM8A/SNRNP70/SNRPA1/SRSF3/DDX46/SRSF8/SF3B2/CHERP/PCBP1	79
KEGG	hsa00190	Oxidative phosphorylation	73/2550	134/8135	1.912e-08	6.027e-07	4.578e-07	NDUFS1/COX7A2L/NDUFS3/UQCRFS1/COX1/COX8A/SDHC/NDUFA11/ND2/ND4/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/NDUFB11/ATP6V1G1/COX6B1/COX17/NDUFA8/COX5B/NDUFAB1/NDUFB7/COX15/NDUFA13/NDUFA2/NDUFA7/UQCR10/NDUFS6/ATP6/CYC1/NDUFB1/NDUFS7/UQCR11/ATP6V1D/NDUFA9/NDUFA1/NDUFA3/NDUFB5/ATP6V1E2/TCIRG1/COX6A1/NDUFS2/NDUFB3/NDUFB4/NDUFV3/PPA1/LHPP/NDUFA4/SDHB/NDUFA12/NDUFA6/NDUFA4L2/NDUFA10/NDUFS4/COX10/ATP6V0A2/COX11/PPA2/COX7B/UQCRC2/ATP6V0B/NDUFC1/COX7C/SDHA/ATP6V0D2/SDHD/COX4I1/NDUFV1/ATP6V1H/ATP6V1E1/COX8C	73
KEGG	hsa03050	Proteasome	33/2550	46/8135	1.985e-08	6.027e-07	4.578e-07	PSMB6/PSMD4/PSMD8/PSMD3/PSMB7/PSMC5/PSMA7/PSMC3/PSMD13/PSMA2/PSMD9/PSMB8/PSMC4/PSMB10/PSMA1/PSMD12/PSMB1/PSMD2/PSMD1/PSME4/PSMB3/PSME1/PSMD14/PSMC6/PSMB5/PSME3/PSMA4/PSMA3/PSMB4/PSMB9/PSMC2/PSMD6/PSMA5	33
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	203/2550	476/8135	5.795e-08	1.613e-06	1.225e-06	NDUFS1/PSMB6/COX7A2L/SLC25A6/NDUFS3/UQCRFS1/BAX/PSMD4/PSMD8/UBE2G2/CALM1/HIP1/PRKCB/COX1/COX8A/SDHC/PSMD3/NDUFA11/PSMB7/PSMC5/ND2/ND4/NDUFB8/DNAL4/BECN1/UQCRQ/NDUFB2/ACTR1B/ULK1/MAP2K6/NDUFB10/COX5A/ATG13/HSD17B10/NDUFB9/PSMA7/NDUFB11/ARAF/COX6B1/DVL3/KRAS/CSNK2A1/NDUFA8/VCP/COX5B/DCTN3/ATF6/NDUFAB1/NDUFB7/CCS/NDUFA13/SMCR8/MAPK11/NDUFA2/NDUFA7/MCU/MAPK8/PSMC3/UQCR10/RAF1/NDUFS6/PSMD13/VDAC2/ATP6/CYC1/MAPK3/NDUFB1/PSMA2/PSMD9/FZD6/PINK1/SLC25A5/FAS/RB1CC1/NDUFS7/UQCR11/FZD2/RELA/NEFH/PSMC4/KIF5B/ITPR1/BRAF/PARK7/GRIN1/MFN1/NDUFA9/NDUFA1/NDUFA3/PSMA1/PSMD12/PSMB1/PSMD2/NDUFB5/ZFYVE1/ATG2A/LRP6/COX6A1/ATXN2L/PSMD1/NDUFS2/IFT57/PSMB3/NDUFB3/ATG2B/CACNA1B/NDUFB4/CSNK1A1/NDUFV3/FADD/CAMK2D/PRKCG/UBE2L3/PSMD14/BAD/PSMC6/NDUFA4/SDHB/EIF2AK3/FZD1/SPG11/TNFRSF1B/NDUFA12/NDUFA6/DCTN6/DCTN5/ITPR3/TBK1/PSMB5/UBA52/CTNNB1/CDK5/BAK1/TARDBP/FRAT2/PSMA4/PSMA3/NDUFA4L2/NDUFA10/DNAH7/UBE2L6/WNT8B/MAP2K2/MAPK9/NFKB1/CAT/ATG14/NDUFS4/PSMB4/RYR2/MAPK1/CSNK1E/PTGS2/COX7B/NOS1/FIG4/UQCRC2/MTOR/DVL2/UBC/PSMC2/CSNK2B/WNT2B/NDUFC1/CASP8/PIK3C3/TUBA1B/VDAC3/SLC6A3/COX7C/WNT11/ATP2A2/KLC2/TUBB1/SDHA/ATXN1L/ACTR10/SDHD/COX4I1/MAPK13/WNT1/ATXN3/TANK/TOMM40L/XBP1/PSMD6/GPX2/NDUFV1/CAPN1/ULK2/HTT/KIF5A/HRAS/DNAH5/WDR41/COX8C/TUBA4A/PSMA5/FZD9/MAP1LC3B2/PPP3R1/SOD1/MAP2K7	203
KEGG	hsa03013	Nucleocytoplasmic transport	60/2550	108/8135	1.387e-07	3.564e-06	2.707e-06	THOC1/ALYREF/NUP153/NUP107/SENP2/TNPO3/NXF1/PNN/TNPO1/UPF1/POM121C/NUP155/SEH1L/THOC5/AHCTF1/SEC13/KPNA2/THOC6/NUP205/XPO4/NUP98/CSE1L/NCBP1/NUP188/NCBP2/ACIN1/SAP18/NUP62/NUP93/KPNB1/NUP50/THOC7/UPF3B/SUMO3/DDX19A/DDX19B/EIF4A3/UPF2/NUP43/RANBP2/NUP133/SUMO1/UBE2I/IPO4/NUP85/NUP35/NUP160/SNUPN/TNPO2/GLE1/POM121/KPNA1/RBM8A/XPO7/RNPS1/NUP37/NXT1/RANGAP1/RAN/KPNA5	60
KEGG	hsa05415	Diabetic cardiomyopathy	95/2550	203/8135	2.249e-06	5.366e-05	4.076e-05	NDUFS1/COX7A2L/SLC25A6/NDUFS3/UQCRFS1/PRKCB/COX1/COX8A/SDHC/NDUFA11/ND2/ND4/NDUFB8/UQCRQ/NDUFB2/NDUFB10/COX5A/NDUFB9/NDUFB11/COX6B1/NDUFA8/COX5B/NDUFAB1/NDUFB7/NDUFA13/MAPK11/NDUFA2/NDUFA7/MAPK8/UQCR10/NDUFS6/VDAC2/ATP6/CYC1/NDUFB1/SLC25A5/NDUFS7/UQCR11/RELA/PPP1CB/NDUFA9/NDUFA1/NDUFA3/NDUFB5/PARP1/PPARA/COX6A1/NDUFS2/COL1A1/NDUFB3/NDUFB4/TGFBR2/GYS2/MPC1/NDUFV3/CAMK2D/MPC2/CPT2/PRKCG/MMP9/NDUFA4/SDHB/NDUFA12/TGFBR1/NDUFA6/PPP1CA/NDUFA4L2/NDUFA10/MAPK9/NFKB1/PIK3CA/PDHB/NDUFS4/RYR2/COX7B/UQCRC2/MTOR/INSR/NDUFC1/RAC2/VDAC3/COX7C/GAPDH/ATP2A2/SDHA/SDHD/COX4I1/MAPK13/AKT1/NDUFV1/AGTR1/COL1A2/PRKCZ/COX8C/PIK3R2	95
KEGG	hsa05017	Spinocerebellar ataxia	69/2550	143/8135	1.533e-05	0.0003414	0.0002593	PSMB6/SLC25A6/PSMD4/PSMD8/PRKCB/PSMD3/PSMB7/PSMC5/RBPJ/BECN1/ULK1/ATG13/PSMA7/MCU/MAPK8/PSMC3/PSMD13/VDAC2/PSMA2/PSMD9/SLC25A5/RB1CC1/PSMC4/ITPR1/GRIN1/GRIN3B/PSMA1/PSMD12/PSMB1/PSMD2/ATG2A/CIC/ATXN2L/PSMD1/PSMB3/TBP/ATG2B/PUM2/PRKCG/ATXN10/PSMD14/PSMC6/AFG3L2/ITPR3/PSMB5/RELN/PSMA4/PSMA3/MAPK9/PIK3CA/ATG14/PSMB4/MTOR/PSMC2/PIK3C3/PUM1/VDAC3/ATP2A2/ATXN1L/NFYA/AKT1/ATXN3/KCNC3/XBP1/PSMD6/DAB1/ULK2/PSMA5/PIK3R2	69
KEGG	hsa04120	Ubiquitin mediated proteolysis	68/2550	142/8135	2.412e-05	0.0005036	0.0003825	CBL/VHL/PRPF19/XIAP/UBE2G2/UBR5/CUL3/UBE2Z/UBE2K/RNF7/KEAP1/ANAPC16/DDB1/PIAS3/ANAPC11/UBE3C/TRIP12/DDB2/SIAH1/UBE4A/ANAPC4/CDC26/HERC4/BIRC2/SKP2/FANCL/UBE2M/BIRC3/CBLB/UBE2D2/PIAS2/MDM2/STUB1/UBE2L3/PPIL2/ERCC8/HERC1/UBA52/SOCS1/UBE2R2/RCHY1/UBE2I/FBXW11/UBE2L6/RHOBTB1/SMURF2/PIAS4/UBE2Q2/ANAPC7/UBE2B/UBC/FZR1/CDC20/CUL2/BIRC6/KLHL9/SKP1/UBE2F/WWP1/CBLC/CUL4A/HUWE1/UBE2S/FBXW7/HERC2/SOCS3/ANAPC15/UBA2	68
KEGG	hsa05220	Chronic myeloid leukemia	41/2550	76/8135	3.368e-05	0.0006617	0.0005026	CBL/GRB2/BAX/ARAF/KRAS/RAF1/CTBP1/MAPK3/RELA/BRAF/DDB2/CRK/CHUK/IKBKB/SHC1/TGFBR2/MDM2/BAD/SOS2/TGFBR1/CDK6/IKBKG/GADD45A/BAK1/CDK4/MAP2K2/NFKB1/PIK3CA/POLK/STAT5A/MAPK1/E2F3/CDKN2A/ABL1/CDKN1A/AKT1/STAT5B/HDAC1/HRAS/PIK3R2/HDAC2	41
KEGG	hsa05161	Hepatitis B	75/2550	162/8135	4.072e-05	0.0007556	0.0005739	GRB2/BAX/CREB1/PRKCB/MAP2K6/ARAF/KRAS/TYK2/DDB1/MAPK11/YWHAB/MAPK8/RAF1/TAB1/MAPK3/FAS/STAT4/RELA/CREBBP/EGR2/BRAF/DDB2/CHUK/IKBKB/CREB3/TGFBR2/NFATC3/FADD/YWHAZ/CREB3L4/MAP2K4/PRKCG/BAD/MMP9/DDX3X/MAP3K7/JAK2/SOS2/PTK2B/ATF2/TGFBR1/IKBKG/TBK1/CREB3L2/IFNAR1/YWHAQ/MAP2K2/MAPK9/NFKB1/PIK3CA/NFATC1/STAT5A/MAPK1/MAVS/E2F3/IFNA17/CCNA2/EGR3/IKBKE/CASP8/TAB2/VDAC3/CCNE2/CDKN1A/MAPK13/PCNA/AKT1/STAT5B/JAK3/NFATC2/HRAS/BIRC5/HSPG2/PIK3R2/MAP2K7	75
KEGG	hsa05223	Non-small cell lung cancer	39/2550	72/8135	4.614e-05	0.000811	0.000616	GRB2/BAX/PRKCB/ARAF/KRAS/RAF1/MAPK3/KIF5B/BRAF/DDB2/EML4/STK4/PRKCG/BAD/SOS2/CDK6/RASSF5/GADD45A/BAK1/CDK4/PDPK1/MAP2K2/PIK3CA/POLK/STAT5A/MAPK1/E2F3/CDKN2A/RXRA/CDKN1A/AKT1/STAT5B/FOXO3/JAK3/EGF/KIF5A/HRAS/PIK3R2/HGF	39
KEGG	hsa04910	Insulin signaling pathway	65/2550	137/8135	5.191e-05	0.0008669	0.0006584	CBL/GRB2/CALM1/FASN/PRKCI/ARAF/INPP5A/KRAS/PRKAG1/MAPK8/RAF1/MAPK3/TSC1/SOCS4/PRKAA1/RPS6KB1/PPP1CB/BRAF/PRKACA/CRK/PPP1R3D/IKBKB/RPS6/SHC1/GYS2/CBLB/PRKAR2A/HK1/PPP1R3E/BAD/SOS2/PRKACB/SREBF1/MKNK1/PHKG1/EIF4E2/PRKAR1A/SOCS1/PPP1CA/EIF4EBP1/PDPK1/MAP2K2/MAPK9/PIK3CA/PRKAR2B/MAPK1/MTOR/RPS6KB2/PYGM/INSR/PPARGC1A/AKT1/PCK2/INPPL1/HK3/LIPE/HKDC1/FBP1/PDE3B/HRAS/PRKCZ/SOCS3/EXOC7/EIF4E/PIK3R2	65
KEGG	hsa05132	Salmonella infection	107/2550	249/8135	5.824e-05	0.0009263	0.0007035	ACTR2/HSP90B1/ARPC1B/BAX/TNFRSF10A/TXN2/M6PR/HSP90AB1/ACTR1B/MAP2K6/PIK3CG/PIK3C2A/ABI1/DCTN3/ELMO2/MAPK11/MAPK8/GSDMD/RAF1/TAB1/MAPK3/WASL/DYNLT3/AHNAK/RELA/VPS11/EXOC4/KIF5B/NCKAP1L/RIPK1/CHUK/BIRC2/CSE1L/ARPC3/GCC2/IKBKB/PYCARD/BRK1/CDC42/CYTH4/FLNA/BIRC3/FADD/MYL7/MAP2K4/MYL12B/VPS39/MAP3K7/PTPRC/TLR5/IKBKG/DCTN6/DCTN5/NAIP/TAB3/CTNNB1/BAK1/MAP2K2/MAPK9/NFKB1/RRAS/PIK3CA/STX10/CASP4/HSP90AA1/RILP/MAPK1/NOD1/ARPC4/ANXA2/ELMO1/CASP8/PIK3C3/TAB2/TRADD/TUBA1B/DYNLL1/PFN1/TLR6/GAPDH/SKP1/FLNB/DYNLL2/KLC2/TUBB1/ACTR10/KPNA1/MAPK13/FHOD1/AKT1/TLR9/PLEKHM2/SNX9/WASF3/NCKAP1/PLEKHM1/DYNLRB1/DYNC1I2/KIF5A/HRAS/EXOC7/MYLPF/TUBA4A/ARHGEF26/VPS41/DNM2/MAP2K7	107
KEGG	hsa04140	Autophagy - animal	66/2550	141/8135	7.663e-05	0.001163	0.0008836	IGBP1/BECN1/ULK1/ATG10/ATG13/KRAS/ATG4B/SMCR8/MAPK8/RAF1/ATG4D/MAPK3/CFLAR/TSC1/ATG9A/LAMP1/PRKAA1/RPS6KB1/RB1CC1/ITPR1/PRKACA/VAMP8/ZFYVE1/ATG2A/ATG12/GABARAPL2/ATG2B/SNAP29/MTMR14/BAD/EIF2AK3/MAP3K7/HIF1A/PRKACB/DEPTOR/TBK1/VMP1/PDPK1/DAPK3/MAP2K2/MAPK9/RRAS/PIK3CA/ATG14/MAPK1/MTOR/RPS6KB2/RRAS2/TP53INP2/PIK3C3/CTSB/RRAGA/EIF2AK4/ATG4A/AKT1/TANK/BNIP3/GABARAP/ULK2/HRAS/WDR41/MRAS/PIK3R2/MAP1LC3B2/PPP2CA/ATG16L2	66
KEGG	hsa05212	Pancreatic cancer	40/2550	76/8135	8.745e-05	0.00127	0.0009645	BAX/RALBP1/ARAF/KRAS/MAPK8/RAF1/MAPK3/RPS6KB1/RELA/BRAF/DDB2/CHUK/IKBKB/CDC42/TGFBR2/BAD/TGFBR1/CDK6/IKBKG/PLD2/GADD45A/BAK1/CDK4/MAPK9/NFKB1/PIK3CA/POLK/MAPK1/RALB/E2F3/RAC3/CDKN2A/MTOR/RPS6KB2/RAC2/VEGFA/CDKN1A/AKT1/EGF/PIK3R2	40
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	96/2550	222/8135	0.0001038	0.001445	0.001098	SLC25A6/CRTC2/XIAP/BAX/CREB1/KRAS/ATR/ANAPC16/MAPK8/VDAC2/MAPK3/SLC25A5/ANAPC11/HLA-A/RELA/B2M/CREBBP/EGR2/ETS1/PRKACA/ITGAL/ANAPC4/CDC26/CALR/CHUK/CCND2/IKBKB/CREB3/MAP3K3/CDKN2C/TBP/TGFBR2/CHEK2/TRRAP/HLA-C/NFATC3/KAT2B/CREB3L4/HLA-DPB1/ELK4/MAP2K4/FDPS/ADCY4/PRKACB/ATF2/TGFBR1/IKBKG/HLA-DPA1/CREB3L2/IL2RB/HLA-G/CDK4/CHEK1/ZFP36/CCNB2/CD3G/MAP2K2/MAPK9/HLA-DOA/NFKB1/PIK3CA/NFKB2/TSPO/NFATC1/STAT5A/MAPK1/DLG1/E2F3/CD3D/CDKN2A/CCNA2/ANAPC7/MAD2L1/CDC20/VDAC3/CCNE2/TNFRSF13C/CDKN1A/RANBP3/SRF/AKT1/STAT5B/HLA-DOB/JAK3/NFATC2/HRAS/ANAPC15/ADCY8/RANBP1/HLA-E/PIK3R2/IL15/PPP3R1/RELB/EGR1/RAN	96
KEGG	hsa05170	Human immunodeficiency virus 1 infection	92/2550	212/8135	0.0001232	0.001557	0.001183	GNB1/BAX/CALM1/PRKCB/AP1G1/BST2/AP1S1/MAP2K6/KRAS/RNF7/ATR/GNAI2/TAP2/DDB1/MAPK11/MAPK8/AP1G2/RAF1/TAB1/MAPK3/FAS/RPS6KB1/HLA-A/RELA/B2M/ITPR1/RIPK1/CRK/CALR/CHUK/APOBEC3C/IKBKB/SAMHD1/HLA-C/NFATC3/FADD/CFL1/PRKCG/BAD/MAP3K7/CXCR4/PTK2B/TNFRSF1B/GNG11/GNG8/IKBKG/ITPR3/TBK1/HLA-G/BAK1/GNA11/TRAF5/CHEK1/CCNB2/GNB4/CD3G/FBXW11/TAPBP/MAP2K2/MAPK9/NFKB1/PIK3CA/NFATC1/AP1S2/PTK2/MAPK1/CD3D/IFNA17/RAC3/PAK2/GNAI1/MTOR/RPS6KB2/CASP8/TAB2/TRADD/RAC2/SKP1/GNG3/GNGT2/MAPK13/AKT1/CUL4A/NFATC2/APOBEC3G/HRAS/GNB2/CCR5/HLA-E/PIK3R2/PPP3R1/MAP2K7	92
KEGG	hsa04150	mTOR signaling pathway	71/2550	156/8135	0.0001259	0.001557	0.001183	GRB2/PRKCB/STRADA/LAMTOR4/ULK1/ATP6V1G1/DVL3/KRAS/TELO2/RAF1/SEH1L/MAPK3/TSC1/MAPKAP1/FZD6/SEC13/PRKAA1/RPS6KB1/FZD2/WDR59/LAMTOR2/BRAF/ATP6V1D/EIF4B/CHUK/SKP2/MIOS/ATP6V1E2/IKBKB/LRP6/RPS6/CAB39/RICTOR/PRKCG/LAMTOR1/SOS2/FZD1/EIF4E2/DEPTOR/CLIP1/LAMTOR5/RPS6KA1/CAB39L/LPIN3/TTI1/EIF4EBP1/PDPK1/WNT8B/MAP2K2/PIK3CA/RPS6KA2/MAPK1/GRB10/LAMTOR3/MTOR/DVL2/RPS6KB2/INSR/WNT2B/RRAGA/WNT11/WNT1/AKT1/ULK2/SLC7A5/ATP6V1H/HRAS/ATP6V1E1/EIF4E/PIK3R2/FZD9	71
KEGG	hsa04218	Cellular senescence	71/2550	156/8135	0.0001259	0.001557	0.001183	SLC25A6/HIPK2/CALM1/MAP2K6/RAD1/KRAS/ATR/SIRT1/MAPK11/MCU/ZFP36L2/RAF1/VDAC2/MAPK3/TSC1/SLC25A5/HLA-A/RELA/ITPR1/PPP1CB/ETS1/LIN52/HIPK3/RBL2/CCND2/TGFBR2/CHEK2/HLA-C/NFATC3/MDM2/RBBP4/TGFBR1/RAD9A/CDK6/RASSF5/GADD45A/ITPR3/PPP1CA/HLA-G/EIF4EBP1/CDK4/CHEK1/CCNB2/FBXW11/MAP2K2/NFKB1/RRAS/PIK3CA/NFATC1/MAPK1/E2F3/CDKN2A/CCNA2/MTOR/MYBL2/RRAS2/VDAC3/CCNE2/CDKN1A/MAPK13/AKT1/FOXO3/MAPKAPK2/NFATC2/CAPN1/HRAS/MRAS/NBN/HLA-E/PIK3R2/PPP3R1	71
KEGG	hsa03015	mRNA surveillance pathway	48/2550	97/8135	0.0001361	0.001623	0.001233	PPP2R1A/ALYREF/NXF1/PNN/UPF1/PABPN1/SSU72/PPP1CB/RNMT/PPP2R3C/CPSF3/PPP2R2A/PABPC1/NCBP1/NCBP2/ACIN1/SAP18/PABPC1L/PCF11/UPF3B/NUDT21/CPSF7/DDX19A/DDX19B/EIF4A3/UPF2/GSPT1/SMG7/PPP2R5E/CPSF4/PPP1CA/PPP2R2D/TARDBP/CSTF2/PPP2R5D/SYMPK/SMG5/GSPT2/GLE1/PAPOLA/RBM8A/PAPOLG/CSTF3/HBS1L/RNPS1/NXT1/WDR82/PPP2CA	48
KEGG	hsa05163	Human cytomegalovirus infection	96/2550	225/8135	0.0001886	0.002172	0.001649	GNB1/IL6R/GRB2/AKAP13/BAX/CREB1/CALM1/PRKCB/MAP2K6/KRAS/GNAI2/TAP2/MAPK11/RAF1/MAPK3/TSC1/FAS/RPS6KB1/HLA-A/RELA/B2M/ITPR1/RIPK1/PRKACA/GNAS/CRK/CALR/CHUK/IKBKB/CREB3/HLA-C/NFATC3/FADD/MDM2/CREB3L4/PRKCG/ADCY4/SOS2/PTGER4/PRKACB/CXCR4/PTK2B/ATF2/GNG11/CDK6/GNG8/IKBKG/ITPR3/TBK1/CREB3L2/CTNNB1/HLA-G/BAK1/EIF4EBP1/CDK4/GNA11/TRAF5/GNB4/TAPBP/MAP2K2/NFKB1/PIK3CA/ARHGEF1/NFATC1/PTK2/MAPK1/E2F3/PTGS2/IFNA17/RAC3/CDKN2A/GNAI1/MTOR/RPS6KB2/CASP8/TRADD/RAC2/VEGFA/GNG3/GNGT2/CDKN1A/MAPK13/GNA13/AKT1/ARHGEF11/ITGAV/NFATC2/PTGER1/CXCR2/HRAS/GNB2/CCR5/ADCY8/HLA-E/PIK3R2/PPP3R1	96
KEGG	hsa05169	Epstein-Barr virus infection	87/2550	202/8135	0.0002541	0.002829	0.002149	BAX/PSMD4/PSMD8/PSMD3/PSMC5/RBPJ/MAP2K6/IRF9/TYK2/TAP2/MAPK11/MAPK8/PSMC3/PSMD13/TAB1/FAS/HLA-A/RELA/PSMC4/B2M/RIPK1/DDB2/ITGAL/PSMD12/PSMD2/CALR/CHUK/SKP2/CCND2/IKBKB/PSMD1/BTK/VIM/HLA-C/FADD/MDM2/HLA-DPB1/MAP2K4/PSMD14/PSMC6/MAP3K7/CDK6/IKBKG/GADD45A/HLA-DPA1/TBK1/IFNAR1/SYK/HLA-G/BAK1/CDK4/TRAF5/CD3G/CIR1/TAPBP/MAPK9/HLA-DOA/NFKB1/PIK3CA/POLK/NFKB2/MAVS/E2F3/CD3D/IFNA17/CCNA2/PSMC2/IKBKE/CASP8/TAB2/TRADD/CCNE2/CDKN1A/MAPK13/AKT1/HDAC1/TNFAIP3/HLA-DOB/JAK3/PSMD6/HLA-E/PIK3R2/OAS2/HDAC2/RELB/SIN3A/MAP2K7	87
KEGG	hsa03010	Ribosome	70/2550	158/8135	0.0003742	0.004032	0.003063	MRPS16/MRPS10/MRPL21/MRPL11/MRPL12/MRPL16/MRPL24/RPL26L1/MRPL14/RPS9/RPL8/MRPL34/MRPL15/MRPS5/RPL37A/MRPS7/MRPL36/MRPL23/MRPL22/MRPS15/MRPL18/FAU/RPS15A/RPS6/MRPL17/RPL12/RPS16/MRPS21/RPLP0/MRPS12/MRPS11/RPS10/MRPS6/RPL15/MRPL28/RPS24/RPL35/RPS18/MRPL27/MRPL3/MRPL1/UBA52/MRPL33/RPS27/RPL39/MRPL13/RPS7/RPL29/RPS5/RPS15/RPL35A/MRPS17/RPL19/RPS4X/RPL36/MRPS2/RPL14/MRPL4/RPS19/MRPL2/RPL10A/RPLP2/RPL41/RPL10L/RPL6/MRPS18A/RPL23A/RPS21/RPL18/RPL32	70
KEGG	hsa04141	Protein processing in endoplasmic reticulum	74/2550	171/8135	0.0006042	0.006306	0.00479	ERP29/SEC31B/HSP90B1/DDOST/BAX/UBE2G2/GANAB/HSP90AB1/BAG1/DNAJC3/SSR4/RPN1/SEC24B/VCP/SSR2/ATF6/MAPK8/UBQLN4/DNAJC1/SEC13/BCAP31/PDIA4/STT3A/TRAM1/EDEM1/RAD23A/SEL1L/CALR/LMAN2/SEC61A2/STT3B/NSFL1C/DAD1/PRKCSH/RAD23B/UBE2D2/NFE2L2/SEC23A/STUB1/PREB/PDIA6/PLAA/EIF2AK3/SEC31A/NPLOC4/SSR1/HSPA1L/SSR3/HSPH1/HYOU1/SEC24D/SEC24C/RPN2/BAK1/DNAJB12/WFS1/MAPK9/HSP90AA1/SIL1/EIF2AK4/SKP1/UBXN1/ATXN3/DERL2/XBP1/UBXN8/HERPUD1/CAPN1/MBTPS1/SEC24A/MBTPS2/RNF185/SAR1A/MAP2K7	74
KEGG	hsa04723	Retrograde endocannabinoid signaling	65/2550	148/8135	0.0007919	0.008015	0.006087	GNB1/NDUFS1/NDUFS3/PRKCB/NDUFA11/ND2/ND4/NDUFB8/NDUFB2/NDUFB10/NDUFB9/NDUFB11/NDUFA8/GNAI2/NDUFAB1/NDUFB7/NDUFA13/MAPK11/NDUFA2/NDUFA7/MAPK8/NDUFS6/MAPK3/NDUFB1/NDUFS7/ITPR1/PRKACA/NDUFA9/NDUFA1/NDUFA3/NDUFB5/GABRR2/NDUFS2/NDUFB3/CACNA1B/NDUFB4/NDUFV3/PRKCG/NDUFA4/ADCY4/PRKACB/GNG11/NDUFA12/NDUFA6/GNG8/ITPR3/SLC32A1/NDUFA4L2/NDUFA10/GNB4/MAPK9/NDUFS4/MAPK1/PTGS2/GNAI1/NDUFC1/DAGLB/GNG3/GNGT2/MAPK13/NDUFV1/GNB2/ADCY8/ABHD6/CNR1	65
KEGG	hsa00020	Citrate cycle (TCA cycle)	18/2550	30/8135	0.001095	0.01075	0.008168	CS/SDHC/FH/MDH2/MDH1/IDH2/SDHB/PC/ACLY/OGDH/IDH3G/PDHB/DLST/SDHA/SDHD/PCK2/ACO1/SUCLG1	18
KEGG	hsa04068	FoxO signaling pathway	58/2550	131/8135	0.001169	0.01116	0.008474	GRB2/CDKN2D/ARAF/KRAS/PRKAG1/SIRT1/PRMT1/NLK/MAPK11/MAPK8/RAF1/MAPK3/SOD2/PRKAA1/S1PR4/CREBBP/BRAF/FBXO32/RBL2/CHUK/SKP2/CCND2/IKBKB/ATG12/GABARAPL2/STK4/TGFBR2/MDM2/HOMER3/SOS2/TGFBR1/GADD45A/PDPK1/CCNB2/IL10/MAP2K2/MAPK9/CAT/PIK3CA/PLK3/MAPK1/CSNK1E/FOXO4/INSR/FOXG1/CCNG2/CDKN1A/MAPK13/AKT1/PCK2/FBXO25/FOXO3/BNIP3/EGF/GABARAP/HRAS/PIK3R2/PLK4	58
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	81/2550	194/8135	0.001264	0.01173	0.008907	GNB1/BAX/CREB1/CALM1/BECN1/MAP2K6/PIK3CG/PREX1/KRAS/IRF9/IL6ST/TYK2/MAPK11/MAPK8/RAF1/MAPK3/FAS/HLA-A/RELA/ITPR1/CREBBP/CHUK/IKBKB/RCAN1/CXCL2/HLA-C/NFATC3/FADD/MAP2K4/PIK3R5/HIF1A/JAK2/GNG11/CDK6/GNG8/IKBKG/ITPR3/TBK1/UBA52/CTNNB1/IFNAR1/SYK/HLA-G/BAK1/CDK4/CD86/ZFP36/GNB4/MAP2K2/MAPK9/NFKB1/PIK3CA/ATG14/NFATC1/MAPK1/E2F3/PTGS2/IFNA17/CCR8/MTOR/UBC/IKBKE/CASP8/PIK3C3/TRADD/VEGFA/GNG3/GNGT2/CDKN1A/MAPK13/AKT1/MAPKAPK2/NFATC2/HRAS/GNB2/CCR5/HLA-E/PIK3R2/MAP1LC3B2/PPP3R1/MAP2K7	81
KEGG	hsa04012	ErbB signaling pathway	40/2550	85/8135	0.001662	0.015	0.0114	CBL/GRB2/PRKCB/ARAF/KRAS/AREG/MAPK8/RAF1/MAPK3/RPS6KB1/BRAF/CRK/SHC1/CBLB/CAMK2D/MAP2K4/PRKCG/BAD/SOS2/EREG/EIF4EBP1/MAP2K2/MAPK9/PIK3CA/STAT5A/PTK2/MAPK1/PAK2/MTOR/RPS6KB2/ABL1/CDKN1A/AKT1/STAT5B/EGF/HBEGF/HRAS/PIK3R2/ABL2/MAP2K7	40
KEGG	hsa01200	Carbon metabolism	51/2550	115/8135	0.002157	0.01873	0.01422	AMT/ALDH6A1/PGLS/CS/SDHC/MCEE/FH/MDH2/ESD/MDH1/IDH2/PCCB/PRPS2/ACOX1/ECHS1/PGK1/HK1/ENO2/SDHB/PC/PGP/TKT/SHMT2/GOT2/TPI1/OGDH/TKTL2/IDH3G/H6PD/RGN/CAT/PDHB/PKM/TALDO1/PGAM1/DLST/GAPDH/ADH5/SDHA/SDHD/HK3/PHGDH/AGXT/HKDC1/FBP1/ACO1/SUCLG1/SDS/SHMT1/PRPS1L1/ALDOA	51
KEGG	hsa03030	DNA replication	20/2550	36/8135	0.002187	0.01873	0.01422	RPA2/RFC2/MCM7/POLE/POLE4/MCM6/RNASEH2A/POLD1/POLD2/RPA4/POLD4/MCM5/SSBP1/FEN1/PRIM1/POLA1/PCNA/RNASEH2C/MCM3/PRIM2	20
KEGG	hsa05203	Viral carcinogenesis	83/2550	204/8135	0.00269	0.02246	0.01706	CHD4/GRB2/SND1/BAX/CREB1/RBPJ/KRAS/IRF9/IL6ST/DDB1/YWHAB/MAPK3/SCRIB/HLA-A/RELA/CREBBP/EGR2/HDAC4/GTF2H4/PRKACA/RBL2/SKP2/CCND2/CREB3/CDC42/TRAF1/TBP/DNAJA3/HLA-C/HDAC3/YWHAZ/MDM2/HDAC8/KAT2B/CREB3L4/BAD/DDX3X/PRKACB/MRPS18B/ATF2/CDK6/IKBKG/CREB3L2/SYK/HLA-G/BAK1/CDK4/TRAF5/CHEK1/HNRNPK/YWHAQ/NFKB1/PIK3CA/NFKB2/STAT5A/PKM/MAPK1/DLG1/CCR8/CDKN2A/CCNA2/EGR3/CASP8/TRADD/CDC20/VDAC3/CCNE2/GTF2H3/ATP6V0D2/CDKN1A/SRF/STAT5B/HDAC1/JAK3/MAPKAPK2/GTF2E2/REL/HRAS/CCR5/RANBP1/HLA-E/PIK3R2/HDAC2	83
KEGG	hsa05165	Human papillomavirus infection	127/2550	331/8135	0.003343	0.02659	0.0202	CHD4/PPP2R1A/GRB2/BAX/CREB1/PRKCI/RBPJ/ATP6V1G1/DVL3/KRAS/ATR/IRF9/TYK2/RAF1/MAPK3/TSC1/FZD6/FAS/RPS6KB1/BCAP31/FZD2/SCRIB/HLA-A/RELA/CREBBP/TUBG2/ATP6V1D/THBS1/PRKACA/GNAS/PPP2R3C/RBL2/NFX1/CHUK/THBS3/CCND2/ATP6V1E2/IKBKB/CREB3/PPP2R2A/TCIRG1/THBS4/CDC42/COL1A1/TBP/HLA-C/CSNK1A1/FADD/MAML1/MDM2/CREB3L4/HES7/BAD/SOS2/PTGER4/PRKACB/FZD1/CDK6/PPP2R5E/IKBKG/TBK1/COL2A1/CREB3L2/CTNNB1/IFNAR1/COMP/RELN/HLA-G/BAK1/EIF4EBP1/PPP2R2D/CDK4/TNN/HES5/WNT8B/MAP2K2/NFKB1/PPP2R5D/PIK3CA/ATP6V0A2/ITGA11/PKM/PTK2/MAPK1/DLG1/ITGA5/PTGS2/IFNA17/CCNA2/MTOR/DVL2/RPS6KB2/WNT2B/ATP6V0B/IKBKE/CASP8/TRADD/DLG3/WNT11/VEGFA/CCNE2/TUBG1/ATP6V0D2/ITGA3/ITGA9/CDKN1A/ITGB5/WNT1/AKT1/COL9A2/ITGAV/HDAC1/ITGA2B/EGF/CHAD/ATP6V1H/HRAS/COL1A2/PRKCZ/ATP6V1E1/ITGB1/COL4A2/HLA-E/PIK3R2/FZD9/HDAC2/PPP2CA	127
KEGG	hsa04210	Apoptosis	58/2550	136/8135	0.003344	0.02659	0.0202	XIAP/BAX/TNFRSF10A/DFFA/CTSZ/LMNB2/KRAS/CTSK/MAPK8/RAF1/MAPK3/CFLAR/PIDD1/FAS/RELA/ITPR1/RIPK1/PARP1/CHUK/BIRC2/NGF/IKBKB/TRAF1/BIRC3/PARP3/FADD/BAD/EIF2AK3/MCL1/ENDOG/CTSC/AIFM1/CTSH/IKBKG/GADD45A/ITPR3/CASP6/CASP2/DFFB/BAK1/PDPK1/LMNB1/MAP2K2/MAPK9/NFKB1/PIK3CA/MAPK1/CASP8/TRADD/TUBA1B/CTSB/AKT1/CAPN1/DIABLO/HRAS/BIRC5/TUBA4A/PIK3R2	58
KEGG	hsa04668	TNF signaling pathway	49/2550	112/8135	0.003645	0.02831	0.0215	CREB1/MAP2K6/MAPK11/MAPK8/TAB1/MAPK3/LIF/CFLAR/FAS/RELA/RIPK1/CHUK/BIRC2/IKBKB/CREB3/TRAF1/RPS6KA4/CXCL2/BIRC3/FADD/BAG4/CREB3L4/MAP2K4/CXCL5/MMP9/MAP3K7/TNFRSF1B/ATF2/IKBKG/TAB3/CREB3L2/TRAF5/MAPK9/NFKB1/PIK3CA/MAPK1/PTGS2/CASP8/TAB2/TRADD/VCAM1/MAPK13/AKT1/TNFAIP3/SOCS3/PIK3R2/IL18R1/IL15/MAP2K7	49
KEGG	hsa04110	Cell cycle	54/2550	126/8135	0.004007	0.03042	0.0231	CDKN2D/RAD21/ATR/ANAPC16/YWHAB/STAG1/ANAPC11/CREBBP/ANAPC4/CDC26/RBL2/MCM7/SKP2/CCND2/CDKN2C/SMC3/CHEK2/CDK7/MCM6/PRKDC/MAD2L2/YWHAZ/SMC1A/MDM2/STAG2/DBF4/CDKN1C/CDK6/GADD45A/CDK4/CDC45/CHEK1/CCNB2/YWHAQ/CDC14B/MCM5/E2F3/CDKN2A/CCNA2/ANAPC7/ORC5/MAD2L1/FZR1/CDC20/ZBTB17/SKP1/CCNE2/ABL1/CDKN1A/PCNA/MCM3/HDAC1/ANAPC15/HDAC2	54
KEGG	hsa01524	Platinum drug resistance	34/2550	73/8135	0.004408	0.03222	0.02447	XIAP/BAX/REV3L/MAPK3/GSTP1/FAS/BIRC2/GSTM5/SLC31A1/BIRC3/FADD/MDM2/ABCC2/BAD/ATP7A/BAK1/PDPK1/PIK3CA/TOP2A/MAPK1/CDKN2A/POLH/MSH6/TOP2B/MGST2/CASP8/CDKN1A/GSTA4/ERCC1/AKT1/MLH1/GSTT2/BIRC5/PIK3R2	34
KEGG	hsa00510	N-Glycan biosynthesis	25/2550	50/8135	0.004437	0.03222	0.02447	DDOST/GANAB/ALG6/RPN1/ALG14/DPM3/FUT8/SRD5A3/STT3A/DOLK/MAN2A2/ALG9/STT3B/DAD1/ALG5/ALG12/DPM2/ALG13/MGAT4B/RPN2/ALG3/DOLPP1/ALG1/ST6GAL1/ALG8	25
KEGG	hsa04664	Fc epsilon RI signaling pathway	32/2550	68/8135	0.004649	0.03266	0.0248	GRB2/MAP2K6/KRAS/MAPK11/VAV1/MAPK8/RAF1/MAPK3/BTK/FCER1A/MAP2K4/SOS2/INPP5D/FYN/SYK/PDPK1/VAV3/MAP2K2/MAPK9/PIK3CA/LCP2/MAPK1/RAC3/RAC2/ALOX5AP/MAPK13/AKT1/IL13/VAV2/HRAS/PIK3R2/MAP2K7	32
KEGG	hsa03410	Base excision repair	18/2550	33/8135	0.004693	0.03266	0.0248	MPG/APEX1/NTHL1/PARP1/POLE/POLE4/PARP3/POLD1/POLD2/TDG/POLD4/UNG/SMUG1/FEN1/OGG1/PCNA/XRCC1/NEIL2	18
KEGG	hsa03250	Viral life cycle - HIV-1	30/2550	63/8135	0.004869	0.03319	0.02521	CDK9/PIN1/BICD2/BST2/NUP153/TNPO3/NELFB/SERINC3/VPS4B/CREBBP/SUPT5H/APOBEC3C/SAMHD1/SUPT4H1/KAT2B/CXCR4/CPSF7/ELL/AFF4/RANBP2/FURIN/CCNT2/ELL2/CCNT1/PPIA/CHMP4B/TSG101/APOBEC3G/CCR5/RAN	30
KEGG	hsa05219	Bladder cancer	21/2550	41/8135	0.006194	0.04137	0.03142	ARAF/KRAS/RAF1/MAPK3/BRAF/THBS1/MDM2/MMP9/CDK4/DAPK3/MAP2K2/MAPK1/E2F3/CDKN2A/VEGFA/UPK3A/CDKN1A/EGF/HBEGF/HRAS/CDH1	21
KEGG	hsa04625	C-type lectin receptor signaling pathway	45/2550	104/8135	0.006632	0.04252	0.03229	CALM1/KRAS/IRF9/MAPK11/MAPK8/RAF1/MAPK3/RELA/ITPR1/EGR2/CHUK/IKBKB/PYCARD/CBLB/NFATC3/MDM2/CLEC1B/IKBKG/ITPR3/SYK/IL10/MAPK9/NFKB1/RRAS/PIK3CA/PLK3/NFKB2/NFATC1/MAPK1/PTGS2/EGR3/RRAS2/IKBKE/CASP8/LSP1/MAPK13/AKT1/MAPKAPK2/NFATC2/HRAS/MRAS/PIK3R2/PPP3R1/RELB/IL17D	45
KEGG	hsa04660	T cell receptor signaling pathway	45/2550	104/8135	0.006632	0.04252	0.03229	GRB2/KRAS/MAPK11/VAV1/MAPK8/RAF1/MAPK3/RELA/CHUK/IKBKB/PDCD1/CDC42/ZAP70/CBLB/NFATC3/MAP3K7/PTPRC/SOS2/IKBKG/FYN/CDK4/PDPK1/VAV3/CD3G/IL10/MAP2K2/MAPK9/NFKB1/PIK3CA/NFATC1/LCP2/MAPK1/DLG1/CD3D/ICOS/PAK2/MAPK13/AKT1/CARD11/NFATC2/VAV2/HRAS/PIK3R2/PPP3R1/MAP2K7	45
KEGG	hsa04137	Mitophagy - animal	33/2550	72/8135	0.006747	0.04252	0.03229	BECN1/ULK1/KRAS/CSNK2A1/FIS1/MAPK8/ATG9A/USP8/PINK1/RELA/MFN1/RHOT2/GABARAPL2/NBR1/EIF2AK3/HIF1A/TBK1/UBA52/MAPK9/RRAS/BCL2L13/UBC/RRAS2/CSNK2B/BNIP3L/TFEB/TBC1D15/FOXO3/BNIP3/GABARAP/HRAS/MRAS/MAP1LC3B2	33
KEGG	hsa03020	RNA polymerase	18/2550	34/8135	0.007089	0.04385	0.0333	POLR2F/POLR2J/POLR3H/POLR2G/POLR2H/POLR2I/CRCP/POLR2B/POLR3K/POLR3F/POLR2L/ZNRD1/POLR2E/TWISTNB/POLR1C/POLR2D/POLR1D/POLR2C	18
KEGG	hsa05205	Proteoglycans in cancer	81/2550	205/8135	0.007398	0.04445	0.03376	CBL/GRB2/PRKCB/ARAF/KRAS/MAPK11/VAV1/RAF1/MAPK3/EZR/FZD6/FAS/RPS6KB1/IQGAP1/FZD2/ITPR1/PPP1CB/BRAF/EIF4B/THBS1/PRKACA/PPP1R12A/RPS6/CDC42/FLNA/COL1A1/CAMK2D/MDM2/PRKCG/MMP9/HIF1A/SOS2/PRKACB/FZD1/TIAM1/CTTN/ITPR3/TWIST1/PDCD4/CTNNB1/PPP1CA/PDPK1/MSN/VAV3/WNT8B/MAP2K2/RRAS/PIK3CA/ARHGEF1/PTK2/MAPK1/ITGA5/MTOR/RPS6KB2/RRAS2/WNT2B/TFAP4/WNT11/VEGFA/FLNB/NUDT16L1/CDKN1A/ITGB5/MAPK13/WNT1/AKT1/LUM/ITGAV/VAV2/HBEGF/HRAS/COL1A2/ITGB1/RDX/MRAS/HSPG2/PIK3R2/FZD9/HGF/SHH/CD63	81
KEGG	hsa04142	Lysosome	55/2550	132/8135	0.007453	0.04445	0.03376	AP3D1/AP3B1/IGF2R/M6PR/AP1G1/AP1S1/CTSZ/GGA3/CTSK/AGA/AP1G2/GNPTG/ACP5/LAMP1/NCOA7/TCIRG1/HEXA/AP3M2/MAN2B1/NAGPA/GGA2/CTSC/CTSH/LAPTM4B/AP3S1/LGMN/DNASE2/LIPA/SUMF1/NAPSA/GNPTAB/ATP6V0A2/AP1S2/DMXL1/CD164/TPP1/ATP6V0B/SORT1/CTSB/CLTA/ATP6V0D2/ABCB9/ARSG/LAPTM4A/NAGA/CLTC/ATP6V1H/CLTB/IDS/HEXB/HYAL2/GALNS/DMXL2/CD63/AP4B1	55
KEGG	hsa05210	Colorectal cancer	38/2550	86/8135	0.008028	0.04704	0.03573	GRB2/BAX/ARAF/KRAS/AREG/MAPK8/RAF1/MAPK3/RPS6KB1/BRAF/APPL1/DDB2/TGFBR2/BAD/SOS2/EREG/TGFBR1/GADD45A/CTNNB1/BAK1/MAP2K2/MAPK9/PIK3CA/POLK/MAPK1/RALB/RAC3/MSH6/MTOR/RPS6KB2/RAC2/CDKN1A/AKT1/MLH1/EGF/HRAS/BIRC5/PIK3R2	38
KEGG	hsa04136	Autophagy - other	17/2550	32/8135	0.008409	0.04842	0.03678	IGBP1/BECN1/ATG10/ATG13/ATG4B/ATG4D/ATG9A/ATG2A/ATG12/GABARAPL2/ATG2B/MTOR/PIK3C3/ATG4A/GABARAP/ULK2/PPP2CA	17
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	39/2550	89/8135	0.008609	0.04874	0.03702	MAP2K6/KRAS/CSNK2A1/MAPK11/RAF1/MAPK3/RPS6KB1/RELA/CHUK/EML4/IKBKB/MAP3K3/PDCD1/ZAP70/BATF/NFATC3/HIF1A/JAK2/CD274/IKBKG/CD3G/MAP2K2/NFKB1/PIK3CA/NFATC1/MAPK1/BATF3/CD3D/MTOR/RPS6KB2/CSNK2B/MAPK13/AKT1/TLR9/NFATC2/EGF/HRAS/PIK3R2/PPP3R1	39
KEGG	hsa01523	Antifolate resistance	16/2550	30/8135	0.009981	0.05556	0.0422	ABCC1/RELA/DHFR/CHUK/IKBKB/ABCC2/SHMT2/IKBKG/NFKB1/ATIC/FOLR2/ABCC3/ALOX12/GGH/TYMS/SHMT1	16
KEGG	hsa05213	Endometrial cancer	27/2550	58/8135	0.01062	0.05812	0.04415	GRB2/BAX/ARAF/KRAS/RAF1/MAPK3/BRAF/DDB2/BAD/SOS2/GADD45A/CTNNB1/BAK1/PDPK1/MAP2K2/PIK3CA/POLK/MAPK1/CDKN1A/AKT1/MLH1/FOXO3/CTNNA1/EGF/HRAS/CDH1/PIK3R2	27
KEGG	hsa00920	Sulfur metabolism	7/2550	10/8135	0.01368	0.07109	0.05399	BPNT1/ETHE1/PAPSS1/TST/MPST/PAPSS2/SELENBP1	7
KEGG	hsa04370	VEGF signaling pathway	27/2550	59/8135	0.01384	0.07109	0.05399	PRKCB/KRAS/MAPK11/RAF1/SH2D2A/MAPK3/CDC42/PRKCG/BAD/MAPKAPK3/SPHK2/MAP2K2/PIK3CA/PTK2/MAPK1/PTGS2/RAC3/RAC2/VEGFA/MAPK13/AKT1/MAPKAPK2/NFATC2/HRAS/SPHK1/PIK3R2/PPP3R1	27
KEGG	hsa04657	IL-17 signaling pathway	40/2550	94/8135	0.01389	0.07109	0.05399	HSP90B1/SRSF1/HSP90AB1/MAPK11/MAPK8/FOSB/MAPK3/S100A8/RELA/CHUK/IKBKB/CXCL2/FADD/LCN2/CXCL5/MMP9/JUND/MAP3K7/MAPK7/IKBKG/TBK1/IL17RC/TAB3/TRAF5/MAPK9/NFKB1/HSP90AA1/IL17RA/MAPK1/PTGS2/IKBKE/CASP8/TAB2/TRADD/MAPK13/TNFAIP3/IL13/TRAF4/IL17D/IL17F	40
KEGG	hsa05214	Glioma	33/2550	75/8135	0.0139	0.07109	0.05399	GRB2/BAX/CALM1/PRKCB/ARAF/KRAS/RAF1/CAMK1D/MAPK3/BRAF/DDB2/SHC1/CAMK2D/CAMK1/MDM2/PRKCG/SOS2/CDK6/GADD45A/BAK1/CDK4/MAP2K2/PIK3CA/POLK/MAPK1/E2F3/CDKN2A/MTOR/CDKN1A/AKT1/EGF/HRAS/PIK3R2	33
KEGG	hsa04071	Sphingolipid signaling pathway	49/2550	119/8135	0.01426	0.07109	0.05399	PPP2R1A/BAX/PRKCB/KRAS/GNAI2/MAPK11/MAPK8/RAF1/ABCC1/MAPK3/S1PR4/RELA/PPP2R3C/CERS2/PPP2R2A/NSMAF/SGMS1/FCER1A/PRKCG/PPP2R5E/PLD2/FYN/SPHK2/PPP2R2D/OPRD1/PDPK1/MAP2K2/MAPK9/NFKB1/PPP2R5D/PIK3CA/MAPK1/RAC3/GNAI1/SPTLC2/TRADD/RAC2/CERS4/SGPL1/MAPK13/GNA13/AKT1/SPTLC1/HRAS/PRKCZ/SGPP2/SPHK1/PIK3R2/PPP2CA	49
KEGG	hsa04935	Growth hormone synthesis, secretion and action	49/2550	119/8135	0.01426	0.07109	0.05399	GRB2/CREB1/PRKCB/MAP2K6/KRAS/GNAI2/MAPK11/MAPK8/RAF1/MAPK3/ITPR1/CREBBP/PRKACA/GNAS/CRK/CREB3/SHC1/CREB3L4/MAP2K4/PRKCG/ADCY4/JAK2/SOS2/PRKACB/ATF2/ITPR3/SOCS1/CREB3L2/GH1/GNA11/MAP2K2/MAPK9/PIK3CA/STAT5A/PTK2/MAPK1/GNAI1/MTOR/MAPK13/AKT1/STAT5B/SST/SSTR1/HRAS/SOCS3/CSH1/ADCY8/GHSR/PIK3R2	49
KEGG	hsa04211	Longevity regulating pathway	38/2550	89/8135	0.01527	0.075	0.05696	BAX/CREB1/ULK1/ATG13/KRAS/PRKAG1/SIRT1/TSC1/SOD2/PRKAA1/RPS6KB1/RB1CC1/ADIPOR1/RELA/APPL1/PRKACA/CREB3/CREB3L4/ADCY4/PRKACB/ATF2/EIF4E2/CREB3L2/EIF4EBP1/NFKB1/CAT/PIK3CA/MTOR/RPS6KB2/INSR/PPARGC1A/EHMT1/AKT1/FOXO3/HRAS/ADCY8/EIF4E/PIK3R2	38
KEGG	hsa00562	Inositol phosphate metabolism	32/2550	73/8135	0.01624	0.07862	0.05971	ALDH6A1/SACM1L/PIK3CG/PIK3C2A/INPP5A/IPPK/PIP4K2B/PLCD1/PIP4K2A/ISYNA1/SYNJ1/MTMR6/MTMR14/IMPA1/PIP4K2C/MTMR1/INPP5D/MIOX/PLCH1/TPI1/PIK3CA/INPP5J/INPP5E/MTMR2/FIG4/PIK3C3/INPPL1/PI4KB/MTM1/MTMR7/PLCH2/PI4K2A	32
KEGG	hsa05225	Hepatocellular carcinoma	66/2550	168/8135	0.01673	0.07984	0.06064	SMARCA2/GRB2/SMARCD2/BAX/PRKCB/ARID1A/ARAF/DVL3/KRAS/KEAP1/RAF1/MAPK3/FZD6/SMARCC1/GSTP1/RPS6KB1/FZD2/BRAF/DDB2/GSTM5/LRP6/PHF10/SHC1/TGFBR2/CSNK1A1/NFE2L2/PRKCG/ARID2/BAD/SOS2/FZD1/TGFBR1/CDK6/GADD45A/CTNNB1/BAK1/CDK4/FRAT2/SMARCA4/NQO1/WNT8B/MAP2K2/PIK3CA/POLK/MAPK1/E2F3/SMARCC2/ARID1B/SMARCD1/CDKN2A/MTOR/DVL2/MGST2/RPS6KB2/WNT2B/WNT11/CDKN1A/GSTA4/WNT1/AKT1/DPF1/HRAS/GSTT2/PIK3R2/FZD9/HGF	66
KEGG	hsa01522	Endocrine resistance	41/2550	98/8135	0.01769	0.08204	0.06231	GRB2/BAX/ARAF/KRAS/MAPK11/MAPK8/RAF1/MAPK3/RPS6KB1/BRAF/PRKACA/GNAS/NCOR1/CDKN2C/SHC1/MDM2/BAD/MMP9/ADCY4/SOS2/DLL1/PRKACB/MED1/CDK4/MAP2K2/MAPK9/PIK3CA/PTK2/MAPK1/E2F3/CDKN2A/MTOR/RPS6KB2/CDKN1A/MAPK13/AKT1/HBEGF/HRAS/ADCY8/BIK/PIK3R2	41
KEGG	hsa05231	Choline metabolism in cancer	41/2550	98/8135	0.01769	0.08204	0.06231	GRB2/WASF2/PRKCB/DGKH/PCYT1A/GPCPD1/KRAS/DGKD/MAPK8/RAF1/MAPK3/TSC1/RPS6KB1/LYPLA1/DGKA/PRKCG/HIF1A/SOS2/PLD2/EIF4EBP1/PDPK1/MAP2K2/CHKB/MAPK9/DGKQ/PIK3CA/MAPK1/RAC3/MTOR/RPS6KB2/RAC2/SLC22A5/CHPT1/AKT1/WASF3/EGF/HRAS/SLC22A3/PCYT1B/SLC22A1/PIK3R2	41
KEGG	hsa03420	Nucleotide excision repair	22/2550	47/8135	0.01862	0.0852	0.06472	DDB1/RPA2/RFC2/GTF2H4/DDB2/RAD23A/POLE/POLE4/RAD23B/CDK7/POLD1/CETN2/POLD2/ERCC2/ERCC8/RPA4/POLD4/ERCC6/GTF2H3/PCNA/ERCC1/CUL4A	22
KEGG	hsa05211	Renal cell carcinoma	30/2550	69/8135	0.02215	0.09998	0.07594	VHL/GRB2/ARAF/FH/KRAS/RAF1/MAPK3/CREBBP/BRAF/ETS1/CRK/EGLN1/CDC42/BAD/HIF1A/SOS2/PRCC/MAP2K2/PIK3CA/RAP1B/MAPK1/PAK2/CUL2/VEGFA/CDKN1A/AKT1/EGLN3/HRAS/PIK3R2/HGF	30
KEGG	hsa00100	Steroid biosynthesis	11/2550	20/8135	0.0238	0.1046	0.07943	SC5D/SOAT1/EBP/NSDHL/DHCR7/LIPA/DHCR24/CYP2R1/CEL/LBR/LSS	11
KEGG	hsa00670	One carbon pool by folate	11/2550	20/8135	0.0238	0.1046	0.07943	AMT/DHFR/MTHFD1/SHMT2/ALDH1L1/ATIC/MTHFD1L/MTR/TYMS/SHMT1/MTFMT	11
KEGG	hsa05215	Prostate cancer	40/2550	97/8135	0.02445	0.106	0.08054	GRB2/HSP90B1/CREB1/HSP90AB1/ARAF/KRAS/RAF1/MAPK3/GSTP1/RELA/CREBBP/BRAF/CHUK/IKBKB/CREB3/NKX3-1/MDM2/CREB3L4/BAD/MMP9/SOS2/IKBKG/CREB3L2/CTNNB1/SRD5A2/PDPK1/MAP2K2/NFKB1/PIK3CA/HSP90AA1/MAPK1/E2F3/MTOR/CCNE2/CDKN1A/AKT1/SPINT1/EGF/HRAS/PIK3R2	40
KEGG	hsa05221	Acute myeloid leukemia	29/2550	67/8135	0.02586	0.1107	0.0841	GRB2/ARAF/KRAS/RAF1/MAPK3/RPS6KB1/RELA/BRAF/CHUK/IKBKB/BAD/SOS2/PPARD/IKBKG/EIF4EBP1/MAP2K2/NFKB1/PIK3CA/CSF1R/STAT5A/MAPK1/CCNA2/MTOR/RPS6KB2/CEBPA/AKT1/STAT5B/HRAS/PIK3R2	29
KEGG	hsa05135	Yersinia infection	54/2550	137/8135	0.02657	0.1123	0.08533	WASF2/ACTR2/ARPC1B/MAP2K6/ELMO2/MAPK11/VAV1/PKN2/MAPK8/TAB1/MAPK3/WASL/RELA/CRK/CHUK/ARPC3/IKBKB/PYCARD/CDC42/ZAP70/NFATC3/MAP2K4/MAP3K7/PTK2B/IKBKG/TBK1/RPS6KA1/VAV3/IL10/MAP2K2/MAPK9/NFKB1/PIK3CA/ARHGEF1/RPS6KA2/NFATC1/LCP2/PTK2/MAPK1/ITGA5/ARPC4/ELMO1/WIPF1/RAC3/TAB2/RAC2/MAPK13/AKT1/NFATC2/VAV2/ITGB1/WIPF2/PIK3R2/MAP2K7	54
KEGG	hsa04926	Relaxin signaling pathway	51/2550	129/8135	0.02878	0.1202	0.09127	GNB1/GRB2/CREB1/ARRB1/KRAS/GNAI2/MAPK11/MAPK8/RAF1/MAPK3/RELA/PRKACA/GNAS/CREB3/SHC1/COL1A1/TGFBR2/CREB3L4/MAP2K4/MMP9/ADCY4/SOS2/PRKACB/ATF2/GNG11/TGFBR1/GNG8/CREB3L2/GNB4/MAP2K2/MAPK9/NFKB1/PIK3CA/MAPK1/NOS1/GNAI1/VEGFA/GNG3/GNGT2/RXFP2/MAPK13/AKT1/RXFP3/HRAS/GNB2/COL1A2/PRKCZ/ADCY8/COL4A2/PIK3R2/MAP2K7	51
KEGG	hsa04064	NF-kappa B signaling pathway	42/2550	104/8135	0.03104	0.128	0.09721	XIAP/PRKCB/CSNK2A1/ERC1/TAB1/CFLAR/PIDD1/RELA/RIPK1/PARP1/CHUK/BIRC2/IKBKB/BTK/TRAF1/CXCL2/ZAP70/BIRC3/MAP3K7/IKBKG/GADD45A/TAB3/LTB/SYK/UBE2I/TRAF5/NFKB1/NFKB2/PIAS4/PTGS2/CSNK2B/CARD10/TAB2/TRADD/VCAM1/TNFRSF13C/TNFAIP3/EDAR/TRIM25/CARD11/EDA/RELB	42
KEGG	hsa03018	RNA degradation	33/2550	79/8135	0.03181	0.1296	0.09842	PAN3/DDX6/XRN1/CNOT2/DCPS/TOB2/EXOSC5/LSM2/PAN2/LSM1/EXOSC10/LSM4/LSM6/EXOSC2/CNOT6L/C1D/PABPC1/PABPC1L/LSM7/LSM8/HSPA9/ENO2/EXOSC4/CNOT10/EDC4/BTG2/DCP1A/EXOSC7/EXOSC3/BTG3/CNOT1/CNOT6/HSPD1	33
KEGG	hsa04146	Peroxisome	34/2550	82/8135	0.03319	0.132	0.1002	PMVK/PXMP2/PRDX5/SOD2/IDH2/PECR/PEX26/ACOX1/PEX1/ACAA1/ECH1/PRDX1/PEX6/AMACR/ACSL3/NUDT7/PEX16/NUDT19/PXMP4/PHYH/CAT/MPV17L/MPV17/ECI2/DAO/PAOX/EHHADH/ACSL5/AGXT/ACSL1/CROT/HMGCL/ACOT8/SOD1	34
KEGG	hsa04662	B cell receptor signaling pathway	34/2550	82/8135	0.03319	0.132	0.1002	GRB2/PRKCB/LILRA4/KRAS/VAV1/RAF1/MAPK3/RELA/CHUK/IKBKB/BTK/NFATC3/SOS2/INPP5D/IKBKG/SYK/VAV3/MAP2K2/NFKB1/PIK3CA/NFATC1/MAPK1/RAC3/LILRA5/RAC2/AKT1/INPPL1/CARD11/NFATC2/VAV2/HRAS/PIK3R2/PPP3R1/CD72	34
KEGG	hsa04151	PI3K-Akt signaling pathway	127/2550	354/8135	0.03546	0.1393	0.1058	GNB1/PPP2R1A/IL6R/GRB2/CRTC2/HSP90B1/CREB1/HSP90AB1/PIK3CG/KRAS/AREG/YWHAB/PKN2/RAF1/MAPK3/TSC1/PRKAA1/RPS6KB1/IL4R/LPAR2/RELA/EIF4B/THBS1/EFNA4/PPP2R3C/RBL2/CHUK/EPHA2/THBS3/CCND2/NGF/MTCP1/IKBKB/CREB3/PPP2R2A/RPS6/THBS4/COL1A1/GYS2/YWHAZ/MDM2/CREB3L4/PIK3R5/BAD/IL7/JAK2/SOS2/MCL1/EREG/ATF2/EIF4E2/GNG11/CDK6/GNG8/PPP2R5E/IKBKG/COL2A1/CREB3L2/FLT4/IFNAR1/SYK/COMP/RELN/IL2RB/EIF4EBP1/PPP2R2D/GH1/CDK4/PDPK1/TNN/GNB4/LPAR4/YWHAQ/MAP2K2/NFKB1/PPP2R5D/PIK3CA/CSF1R/HSP90AA1/ITGA11/PTK2/MAPK1/ITGA5/IFNA17/MTOR/RPS6KB2/RXRA/INSR/FGF10/VEGFA/OSM/CCNE2/GNG3/PHLPP1/GNGT2/LPAR3/ITGA3/ITGA9/CDKN1A/ITGB5/AKT1/LPAR5/PCK2/COL9A2/ITGAV/FOXO3/JAK3/ITGA2B/F2R/PGF/FGF3/FGF16/EGF/CHAD/MYB/HRAS/GNB2/COL1A2/PHLPP2/ITGB1/CSH1/EIF4E/COL4A2/LPAR6/PIK3R2/PPP2CA/HGF	127
KEGG	hsa00513	Various types of N-glycan biosynthesis	18/2550	39/8135	0.03688	0.1432	0.1088	DDOST/RPN1/ALG14/FUT8/STT3A/MAN2A2/ALG9/STT3B/DAD1/HEXA/ALG12/ALG13/MGAT4B/RPN2/ALG3/B4GALNT3/HEXB/ALG1	18
KEGG	hsa04380	Osteoclast differentiation	50/2550	128/8135	0.03764	0.1445	0.1097	GRB2/CREB1/MAP2K6/LILRA4/IRF9/TYK2/CTSK/MAPK11/MAPK8/FOSB/ACP5/TAB1/MAPK3/RELA/CHUK/FOSL2/IKBKB/BTK/TGFBR2/JUND/MAP3K7/TGFBR1/IKBKG/FYN/SOCS1/IFNAR1/SYK/MAPK9/NFKB1/PIK3CA/FHL2/CSF1R/NFKB2/FCGR3B/TREM2/NFATC1/LCP2/MAPK1/LILRA5/TAB2/MAPK13/AKT1/TYROBP/NFATC2/SOCS3/PIK3R2/PPP3R1/RELB/SIRPG/MAP2K7	50
KEGG	hsa05160	Hepatitis C	60/2550	157/8135	0.03859	0.1465	0.1112	PPP2R1A/GRB2/BAX/ARAF/KRAS/IRF9/TYK2/YWHAB/RAF1/MAPK3/CFLAR/FAS/RELA/BRAF/RIPK1/CHUK/IKBKB/PPP2R2A/PPARA/FADD/YWHAZ/BAD/EIF2AK3/SOS2/CDK6/IKBKG/TBK1/PSME3/CTNNB1/IFNAR1/BAK1/PPP2R2D/CDK4/CLDN2/NR1H3/YWHAQ/MAP2K2/NFKB1/PIK3CA/MAPK1/MAVS/E2F3/IFNA17/RXRA/IKBKE/CASP8/TRADD/EIF2AK4/CLDN5/SCARB1/CDKN1A/AKT1/EGF/HRAS/SOCS3/CLDN6/PIK3R2/OAS2/PPP2CA/OCLN	60
KEGG	hsa04144	Endocytosis	92/2550	251/8135	0.03949	0.1482	0.1126	CBL/ACTR2/ARF5/ARPC1B/IGF2R/ARFGEF1/IQSEC1/ARF3/PRKCI/SNX3/RAB11FIP3/SNX12/RABEP1/ARRB1/VPS26B/IST1/ZFYVE27/WASL/SNF8/USP8/HLA-A/VPS4B/KIF5B/ARFGAP2/CHMP2A/ARFGEF2/ACAP3/AGAP6/SMAP2/ARPC3/GBF1/RUFY2/SPG21/SH3KBP1/SNX4/CDC42/CYTH4/TGFBR2/HLA-C/CBLB/EPN1/ASAP1/MDM2/VPS28/CXCR4/HSPA1L/VPS35/TGFBR1/MVB12A/PLD2/AP2B1/IL2RB/HLA-G/VPS25/CXCR1/EEA1/SMURF2/GRK4/AP2S1/RAB11FIP5/ARPC4/WIPF1/FOLR2/RAB31/CLTA/VPS37B/ARFGAP1/CHMP4B/WWP1/RNF41/VPS26A/CBLC/RAB10/DNAJC6/TSG101/SH3GL3/VPS45/CLTC/CXCR2/KIF5A/HRAS/PRKCZ/AP2A2/CLTB/CCR5/WIPF2/RAB35/HLA-E/DNM3/RAB22A/DNM2/ZFYVE16	92
KEGG	hsa04152	AMPK signaling pathway	47/2550	120/8135	0.04093	0.1519	0.1154	PPP2R1A/CRTC2/CREB1/FASN/RAB14/STRADA/ULK1/PRKAG1/SIRT1/TSC1/PRKAA1/RPS6KB1/ADIPOR1/PPP2R3C/CREB3/PPP2R2A/CAB39/GYS2/CREB3L4/MAP3K7/SREBF1/TBC1D1/PPP2R5E/CAB39L/CREB3L2/EIF4EBP1/PPP2R2D/PDPK1/LEPR/PPP2R5D/PIK3CA/EEF2/CCNA2/MTOR/RPS6KB2/INSR/PPARGC1A/RAB2A/AKT1/PCK2/RAB10/FOXO3/SCD/LIPE/FBP1/PIK3R2/PPP2CA	47
KEGG	hsa04621	NOD-like receptor signaling pathway	69/2550	184/8135	0.04246	0.1558	0.1184	NLRP1/XIAP/TXN2/HSP90AB1/IRF9/TYK2/MAPK11/PKN2/MCU/MAPK8/GSDMD/VDAC2/TAB1/MAPK3/RELA/ITPR1/RIPK1/MFN1/CHUK/BIRC2/TXNIP/IKBKB/PYCARD/ATG12/GABARAPL2/CXCL2/BIRC3/GBP5/FADD/MAP3K7/NLRP12/IKBKG/ITPR3/NLRP7/TBK1/NAIP/TAB3/TRIP6/IFNAR1/TRAF5/TRPV2/MAPK9/NFKB1/CASP4/HSP90AA1/MAPK1/NOD1/MAVS/NLRX1/IFNA17/PANX1/IKBKE/CASP8/TAB2/CTSB/VDAC3/DHX33/ANTXR2/MAPK13/TANK/TNFAIP3/GBP2/GBP3/GABARAP/CAMP/SHARPIN/BRCC3/OAS2/MAP1LC3B2	69
KEGG	hsa01250	Biosynthesis of nucleotide sugars	17/2550	37/8135	0.04383	0.1574	0.1196	PMM1/UGP2/TSTA3/GALT/HK1/NAGK/GALK1/NANS/MIOX/UGDH/UAP1L1/PGM2/GALK2/HK3/HKDC1/PGM3/GMDS	17
KEGG	hsa05216	Thyroid cancer	17/2550	37/8135	0.04383	0.1574	0.1196	BAX/KRAS/MAPK3/BRAF/DDB2/CCDC6/GADD45A/CTNNB1/BAK1/TPM3/MAP2K2/POLK/MAPK1/RXRA/CDKN1A/HRAS/CDH1	17
KEGG	hsa04371	Apelin signaling pathway	53/2550	139/8135	0.05152	0.1831	0.139	GNB1/CALM1/BECN1/PIK3CG/KRAS/PRKAG1/GNAI2/RAF1/MAPK3/PRKAA1/RPS6KB1/ITPR1/HDAC4/PRKACA/TFAM/RPS6/PIK3R5/ADCY4/PRKACB/GNG11/TGFBR1/GNG8/ITPR3/SPHK2/GNB4/MAP2K2/RRAS/RYR2/MAPK1/NOS1/GNAI1/MTOR/RPS6KB2/RRAS2/PIK3C3/PPARGC1A/GNG3/GNGT2/GNA13/AKT1/LIPE/MEF2D/AGTR1/PDE3B/HRAS/GNB2/ADCY8/APLN/MRAS/SPHK1/CDH1/MAP1LC3B2/EGR1	53
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	32/2550	79/8135	0.05251	0.1846	0.1402	IL6R/GRB2/BAX/PRKCB/ARAF/KRAS/RAF1/MAPK3/RPS6KB1/BRAF/RPS6/SHC1/PRKCG/BAD/JAK2/SOS2/EIF4E2/EIF4EBP1/MAP2K2/PIK3CA/MAPK1/MTOR/RPS6KB2/GAS6/VEGFA/AKT1/FOXO3/EGF/HRAS/EIF4E/PIK3R2/HGF	32
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	14/2550	30/8135	0.05634	0.196	0.1489	AMT/CS/MCEE/MDH2/MDH1/PCCB/HOGA1/AFMID/PGP/SHMT2/CAT/AGXT/ACO1/SHMT1	14
KEGG	hsa04931	Insulin resistance	42/2550	108/8135	0.05705	0.1964	0.1492	CRTC2/CREB1/PRKCB/OGT/PRKAG1/MAPK8/PRKAA1/RPS6KB1/RELA/PPP1CB/SLC27A5/PPP1R3D/IKBKB/CREB3/PPARA/GYS2/CREB3L4/PPP1R3E/SREBF1/SLC27A1/RPS6KA1/CREB3L2/PPP1CA/PDPK1/NR1H3/PPARGC1B/MAPK9/NFKB1/PIK3CA/RPS6KA2/MTOR/RPS6KB2/PYGM/INSR/NR1H2/PPARGC1A/SLC27A6/AKT1/PCK2/PRKCZ/SOCS3/PIK3R2	42
KEGG	hsa03440	Homologous recombination	18/2550	41/8135	0.06113	0.2084	0.1582	TOP3B/RPA2/TOPBP1/BABAM1/TOP3A/POLD1/POLD2/RPA4/BLM/BARD1/RAD51D/POLD4/UIMC1/SSBP1/RAD54B/RAD51C/NBN/BRCC3	18
KEGG	hsa05130	Pathogenic Escherichia coli infection	72/2550	197/8135	0.06616	0.2232	0.1695	WASF2/ACTR2/ARPC1B/BAX/TNFRSF10A/SEC24B/ABI1/MAPK11/MAPK8/TAB1/MAPK3/WASL/EZR/ABCF2/FAS/LPAR2/RELA/NCKAP1L/RIPK1/TMED10/CHUK/ARPC3/IKBKB/PYCARD/BRK1/CDC42/CYTH4/FADD/MAP3K7/TLR5/CTTN/IKBKG/FYN/SEC24D/NAIP/TAB3/SEC24C/BAK1/CLDN2/LPAR4/MAPK9/NFKB1/ARHGEF1/CASP4/MAPK1/ARPC4/WIPF1/PAK2/CASP8/TAB2/TRADD/TUBA1B/CLDN5/GAPDH/MYO5C/TUBB1/ABL1/MYH9/MAPK13/GNA13/LPAR5/ARHGEF11/F2/F2R/WASF3/NCKAP1/SEC24A/ITGB1/WIPF2/CLDN6/TUBA4A/OCLN	72
KEGG	hsa05218	Melanoma	29/2550	72/8135	0.06722	0.2245	0.1705	BAX/ARAF/KRAS/RAF1/MAPK3/BRAF/DDB2/MDM2/BAD/CDK6/GADD45A/BAK1/CDK4/MAP2K2/PIK3CA/POLK/MAPK1/E2F3/CDKN2A/FGF10/CDKN1A/AKT1/FGF3/FGF16/EGF/HRAS/CDH1/PIK3R2/HGF	29
KEGG	hsa05222	Small cell lung cancer	36/2550	92/8135	0.06798	0.2248	0.1707	XIAP/BAX/RELA/CKS1B/DDB2/CHUK/BIRC2/SKP2/IKBKB/TRAF1/BIRC3/CDK6/IKBKG/GADD45A/BAK1/CDK4/TRAF5/NFKB1/PIK3CA/POLK/PTK2/E2F3/PTGS2/RXRA/ZBTB17/CCNE2/ITGA3/CDKN1A/CKS2/AKT1/ITGAV/ITGA2B/TRAF4/ITGB1/COL4A2/PIK3R2	36
KEGG	hsa01230	Biosynthesis of amino acids	30/2550	75/8135	0.06913	0.2264	0.1719	CS/IDH2/PRPS2/PGK1/ENO2/ARG1/PC/ARG2/TKT/SHMT2/GOT2/TPI1/TKTL2/OTC/IDH3G/ASL/PKM/TALDO1/CTH/PGAM1/GAPDH/MAT2A/MTR/ASNS/PHGDH/ACO1/SDS/SHMT1/PRPS1L1/ALDOA	30
KEGG	hsa03430	Mismatch repair	11/2550	23/8135	0.07252	0.2352	0.1786	RPA2/RFC2/POLD1/MLH3/POLD2/RPA4/POLD4/SSBP1/MSH6/PCNA/MLH1	11
KEGG	hsa05168	Herpes simplex virus 1 infection	170/2550	495/8135	0.07664	0.241	0.183	ZNF641/BAX/SRSF1/ALYREF/ZNF155/BST2/SRSF4/NXF1/IRF9/TYK2/TAP2/TAB1/ZNF669/TSC1/ZNF383/ZNF562/FAS/ZNF567/HLA-A/RELA/ZNF26/B2M/PPP1CB/ZNF709/ZNF212/ZNF337/ZNF571/CALR/ZNF558/CHUK/BIRC2/ZNF783/ZNF566/IKBKB/ZNF440/ZNF100/ZNF808/ZNF8/ZNF43/ZNF184/SRPK1/ZNF611/ZNF224/ZNF324/ZNF331/ZNF570/POU2F1/HLA-C/ZNF275/BIRC3/FADD/ZNF200/ZNF700/ZNF222/ZNF10/ZNF677/ZNF582/ZNF548/HLA-DPB1/ZNF91/BAD/ZNF814/EIF2AK3/MAP3K7/ZNF556/JAK2/ZNF140/ZNF41/ZNF682/ZNF19/ZNF250/IKBKG/HLA-DPA1/TBK1/EIF2B4/ZNF713/SRSF6/IFNAR1/ZNF600/SYK/PPP1CA/ZNF778/ZNF461/HLA-G/ZNF684/BAK1/ZNF432/EIF4EBP1/ZNF793/ZNF189/TRAF5/ZNF480/ZNF268/ZNF555/ZNF316/ZNF436/POU2F2/TAPBP/ZNF540/HLA-DOA/NFKB1/ZNF565/ZNF136/ZNF506/PIK3CA/ZNF251/ZNF300/ZNF597/ZNF2/ZNF282/ZNF273/MAVS/ITGA5/ZNF23/ZNF205/ZNF805/IFNA17/ZNF33A/MTOR/ZFP30/ZNF225/ZNF615/ZNF689/ZNF182/ZNF568/EIF2B5/IKBKE/CASP8/TAB2/TRADD/ZNF675/ZNF17/EIF2AK4/ZNF230/ZNF763/ZNF141/EIF2B3/EIF2B1/ZNF79/ZNF12/ZNF333/AKT1/ZNF736/TLR9/ZNF578/ZNF587/ZNF530/HLA-DOB/ZNF425/SRSF3/ZNF124/ZNF93/SRSF8/ZNF443/ZNF585A/ZNF45/SOCS3/ZNF785/ZNF85/ZNF630/ZNF589/ZNF782/HLA-E/PIK3R2/OAS2/ZNF607/ZNF850/ZNF514/PILRA/ZNF107	170
KEGG	hsa03450	Non-homologous end-joining	7/2550	13/8135	0.07717	0.241	0.183	XRCC6/POLM/PRKDC/DNTT/FEN1/XRCC5/LIG4	7
KEGG	hsa04917	Prolactin signaling pathway	28/2550	70/8135	0.07719	0.241	0.183	GRB2/KRAS/MAPK11/MAPK8/RAF1/MAPK3/SOCS4/SOCS7/RELA/CCND2/SHC1/GALT/JAK2/SOS2/SOCS1/MAP2K2/MAPK9/NFKB1/PIK3CA/STAT5A/MAPK1/MAPK13/AKT1/STAT5B/FOXO3/HRAS/SOCS3/PIK3R2	28
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	28/2550	70/8135	0.07719	0.241	0.183	ATP6V1G1/MAPK11/MAPK8/RELA/ATP6V1D/CHUK/ADAM10/ATP6V1E2/IKBKB/TCIRG1/CDC42/CXCL2/MAP2K4/IKBKG/CXCR1/MAPK9/NFKB1/ATP6V0A2/NOD1/CSK/ATP6V0B/ATP6V0D2/MAPK13/F11R/CXCR2/HBEGF/ATP6V1H/ATP6V1E1	28
KEGG	hsa04115	p53 signaling pathway	29/2550	73/8135	0.0792	0.2449	0.186	SIVA1/BAX/TNFRSF10A/CD82/ATR/PIDD1/FAS/THBS1/DDB2/SIAH1/GORAB/CCND2/CHEK2/MDM2/RPRM/CDK6/GADD45A/RRM2B/RCHY1/CDK4/CHEK1/TP53I3/CCNB2/CDKN2A/CASP8/CCNG2/CCNE2/CDKN1A/STEAP3	29
KEGG	hsa04213	Longevity regulating pathway - multiple species	25/2550	62/8135	0.08392	0.2554	0.194	KRAS/PRKAG1/SIRT1/SOD2/PRKAA1/RPS6KB1/PRKACA/ADCY4/PRKACB/HSPA1L/CLPB/CAT/PIK3CA/EIF4EBP2/MTOR/RPS6KB2/INSR/AKT1/HDAC1/FOXO3/HRAS/ADCY8/PIK3R2/HDAC2/SOD1	25
KEGG	hsa04659	Th17 cell differentiation	41/2550	108/8135	0.08413	0.2554	0.194	IL6R/HSP90AB1/IL6ST/TYK2/MAPK11/MAPK8/IL27RA/MAPK3/IL4R/RELA/CHUK/IKBKB/ZAP70/TGFBR2/NFATC3/HLA-DPB1/HIF1A/JAK2/TGFBR1/IKBKG/HLA-DPA1/IL2RB/CD3G/MAPK9/HLA-DOA/NFKB1/HSP90AA1/NFATC1/STAT5A/MAPK1/CD3D/MTOR/RXRA/IL21R/MAPK13/STAT5B/HLA-DOB/JAK3/NFATC2/PPP3R1/IL17F	41
KEGG	hsa03460	Fanconi anemia pathway	22/2550	54/8135	0.09107	0.274	0.2081	EME2/REV3L/ATR/TELO2/TOP3B/WDR48/RPA2/TOP3A/FANCL/FANCI/RPA4/FANCF/BLM/USP1/FANCE/POLK/FANCG/POLH/SLX4/ERCC1/MLH1/RAD51C	22
KEGG	hsa00071	Fatty acid degradation	18/2550	43/8135	0.09453	0.2819	0.2141	HADHA/ECI1/HADH/ACOX1/ECHS1/ACAA1/CPT2/ACSL3/ALDH9A1/ALDH3A2/ACADVL/CYP2U1/ECI2/ADH5/EHHADH/ACSL5/ACSL1/GCDH	18
KEGG	hsa04062	Chemokine signaling pathway	69/2550	192/8135	0.09624	0.2845	0.2161	GNB1/GRB2/PRKCB/PIK3CG/PREX1/ARRB1/KRAS/GNAI2/VAV1/RAF1/MAPK3/RELA/BRAF/CCR10/PRKACA/CRK/CHUK/IKBKB/CDC42/SHC1/CXCL2/CXCR5/PIK3R5/CXCL5/BAD/ADCY4/JAK2/SOS2/PRKACB/CXCR4/PTK2B/GNG11/TIAM1/GNG8/IKBKG/CXCR1/VAV3/GNB4/NFKB1/PIK3CA/GRK4/RAP1B/PTK2/MAPK1/PPBP/XCR1/ELMO1/CCR8/RAC3/GNAI1/CCR2/PF4/RAC2/GNG3/GNGT2/AKT1/STAT5B/FOXO3/JAK3/VAV2/CXCR2/HRAS/GNB2/PRKCZ/PF4V1/CCR5/ADCY8/CCL27/PIK3R2	69
KEGG	hsa00310	Lysine degradation	25/2550	63/8135	0.09916	0.2905	0.2207	HADHA/DHTKD1/KMT2A/HADH/ECHS1/EZH1/TMLHE/SETD2/KMT2B/EZH2/DOT1L/PLOD3/KMT2C/ALDH9A1/ALDH3A2/CAMKMT/DLST/SETD1B/EHHADH/EHMT1/GCDH/PLOD1/ASH1L/SETMAR/PHYKPL	25
KEGG	hsa04658	Th1 and Th2 cell differentiation	35/2550	92/8135	0.1016	0.2937	0.2231	RBPJ/TYK2/MAPK11/MAPK8/MAPK3/STAT4/IL4R/RELA/CHUK/IKBKB/ZAP70/NFATC3/MAML1/HLA-DPB1/JAK2/DLL1/IKBKG/HLA-DPA1/IL2RB/CD3G/MAPK9/HLA-DOA/NFKB1/NFATC1/STAT5A/MAPK1/CD3D/MAPK13/STAT5B/HLA-DOB/JAK3/IL13/NFATC2/PPP3R1/MAF	35
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	20/2550	49/8135	0.1022	0.2937	0.2231	PMM1/UGP2/TSTA3/GALT/HEXA/HK1/NAGK/GALK1/NANS/UGDH/GNPDA1/CYB5R3/UAP1L1/PGM2/GALK2/HK3/HKDC1/PGM3/HEXB/GMDS	20
KEGG	hsa04072	Phospholipase D signaling pathway	54/2550	148/8135	0.1029	0.2937	0.2231	GRB2/DGKH/PIK3CG/KRAS/DGKD/RAF1/MAPK3/TSC1/LPAR2/GNAS/SHC1/CYTH4/DGKA/AGPAT3/FCER1A/PIK3R5/ADCY4/SOS2/PTK2B/PLD2/FYN/SYK/SPHK2/CXCR1/LPAR4/MAP2K2/DGKQ/RRAS/PIK3CA/MAPK1/RALB/MTOR/RRAS2/INSR/AGPAT4/LPAR3/GNA13/AKT1/LPAR5/F2/F2R/EGF/AGTR1/CXCR2/HRAS/ADCY8/MRAS/SPHK1/GRM6/DNM3/LPAR6/AGPAT1/PIK3R2/DNM2	54
KEGG	hsa00030	Pentose phosphate pathway	13/2550	30/8135	0.1128	0.3176	0.2413	PGLS/PRPS2/TKT/TKTL2/H6PD/RGN/DERA/TALDO1/PGM2/RBKS/FBP1/PRPS1L1/ALDOA	13
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/2550	14/8135	0.1138	0.3176	0.2413	FUT8/ST3GAL1/B4GALT4/ST3GAL2/B3GNT2/CHST1/CHST2	7
KEGG	hsa04810	Regulation of actin cytoskeleton	77/2550	218/8135	0.1141	0.3176	0.2413	WASF2/ACTR2/ARPC1B/DIAPH1/ARAF/KRAS/VAV1/PIP4K2B/RAF1/MAPK3/WASL/EZR/IQGAP1/LPAR2/NCKAP1L/PPP1CB/BRAF/PIP4K2A/ITGAL/CRK/PPP1R12A/ARPC3/ARHGAP35/SPATA13/BRK1/CDC42/CFL1/MYL7/ITGAE/MYL12B/PIP4K2C/SOS2/CXCR4/TIAM1/PPP1CA/MSN/VAV3/LPAR4/MAP2K2/RRAS/PIK3CA/ARHGEF1/ITGA11/PTK2/MAPK1/ITGA5/ARPC4/RAC3/PAK2/RRAS2/FGF10/RAC2/PFN1/CHRM4/MYH9/ITGA3/ITGA9/ITGB5/GNA13/MOS/LPAR5/ITGAV/DIAPH3/F2/ITGA2B/F2R/NCKAP1/FGF3/VAV2/FGF16/EGF/HRAS/ITGB1/MYLPF/RDX/MRAS/PIK3R2	77
KEGG	hsa04010	MAPK signaling pathway	102/2550	294/8135	0.1163	0.3211	0.2439	GRB2/PRKCB/MAP2K6/ARAF/ARRB1/KRAS/AREG/NLK/PPM1B/MAPK11/MAPK8/RAF1/TAB1/MAPK3/STMN1/MAP3K4/FAS/TAOK2/MAP4K3/RELA/BRAF/CACNA2D3/PRKACA/CRK/EFNA4/CHUK/EPHA2/NGF/IKBKB/MAP3K3/CDC42/RPS6KA4/FLNA/CACNA1B/STK4/TGFBR2/NFATC3/ELK4/MAP2K4/PRKCG/MAP3K11/JUND/MAPKAPK3/MAP3K7/CACNG1/SOS2/PRKACB/HSPA1L/EREG/MAPK7/MKNK1/ATF2/TGFBR1/IKBKG/GADD45A/RPS6KA1/FLT4/MAP2K2/MAPK9/NFKB1/RRAS/CSF1R/NFKB2/RAP1B/RPS6KA2/NFATC1/DUSP10/DUSP5/MAPK1/RAC3/PAK2/CACNB2/LAMTOR3/MAP3K6/RRAS2/INSR/FGF10/TAB2/TRADD/RAC2/VEGFA/FLNB/RASA1/MAPK13/SRF/AKT1/MAPKAPK2/PGF/CACNG7/DUSP2/FGF3/FGF16/EGF/MAPK8IP2/HRAS/MRAS/MAP4K2/CACNB4/PPP3R1/HGF/RELB/MAP2K7	102
KEGG	hsa04914	Progesterone-mediated oocyte maturation	38/2550	102/8135	0.1185	0.3243	0.2463	HSP90AB1/ARAF/KRAS/GNAI2/ANAPC16/MAPK11/MAPK8/RAF1/MAPK3/ANAPC11/BRAF/PRKACA/ANAPC4/SPDYE2/CDC26/MAD2L2/ADCY4/PRKACB/RPS6KA1/STK10/CCNB2/MAPK9/PIK3CA/HSP90AA1/RPS6KA2/MAPK1/GNAI1/CCNA2/ANAPC7/MAD2L1/FZR1/MAPK13/AKT1/MOS/PDE3B/ANAPC15/ADCY8/PIK3R2	38
KEGG	hsa04015	Rap1 signaling pathway	74/2550	210/8135	0.1243	0.3375	0.2563	CALM1/PRKCB/PRKCI/MAP2K6/KRAS/APBB1IP/GNAI2/KRIT1/MAPK11/VAV1/RAF1/MAPK3/SIPA1L1/LPAR2/BRAF/GRIN1/THBS1/GNAS/ITGAL/CRK/EFNA4/EPHA2/NGF/CDC42/PRKCG/ADCY4/TIAM1/RASSF5/RAP1GAP/ID1/CTNNB1/FLT4/VAV3/LPAR4/MAP2K2/RRAS/PIK3CA/CSF1R/RAP1B/SIPA1/LCP2/MAPK1/RALB/RAC3/DOCK4/GNAI1/INSR/FGF10/RAC2/PFN1/VASP/VEGFA/LPAR3/MAPK13/AKT1/LPAR5/ITGA2B/F2R/PGF/FGF3/VAV2/FGF16/EGF/HRAS/PRKCZ/ITGB1/ADCY8/PRKD3/MRAS/CDH1/PIK3R2/HGF/FPR1/CNR1	74
KEGG	hsa04611	Platelet activation	45/2550	124/8135	0.1364	0.3674	0.279	PRKCI/PIK3CG/APBB1IP/GNAI2/MAPK11/MAPK3/ITPR1/PPP1CB/PRKACA/GNAS/VAMP8/PPP1R12A/ARHGAP35/BTK/P2RY12/COL1A1/PIK3R5/MYL12B/ADCY4/PRKACB/ITPR3/FYN/SYK/PPP1CA/FGB/PIK3CA/ARHGEF1/RAP1B/SNAP23/LCP2/MAPK1/GNAI1/FGG/VASP/MAPK13/GNA13/AKT1/F2/ITGA2B/F2R/COL1A2/PRKCZ/ITGB1/ADCY8/PIK3R2	45
KEGG	hsa05162	Measles	50/2550	139/8135	0.1375	0.3674	0.279	BAX/CSNK2A1/IRF9/TYK2/MAPK8/FAS/RELA/CD46/CHUK/CCND2/IKBKB/CBLB/FADD/BAD/EIF2AK3/MAP3K7/HSPA1L/CDK6/IKBKG/TBK1/IFNAR1/IL2RB/BAK1/RCHY1/CDK4/MSN/CD3G/MAPK9/NFKB1/ADAR/PIK3CA/STAT5A/MAVS/CD3D/IFNA17/CSNK2B/IKBKE/CASP8/TAB2/TRADD/EIF3H/EIF2AK4/CCNE2/AKT1/TLR9/STAT5B/TNFAIP3/JAK3/PIK3R2/OAS2	50
KEGG	hsa05100	Bacterial invasion of epithelial cells	29/2550	77/8135	0.1411	0.3741	0.2841	CBL/WASF2/ACTR2/ARPC1B/ELMO2/WASL/CRK/CD2AP/ARPC3/CDC42/SHC1/MAD2L2/CTTN/CTNNB1/PIK3CA/PTK2/ITGA5/ARPC4/ELMO1/CLTA/CTNNA1/CLTC/CLTB/ITGB1/CDH1/DNM3/ARHGEF26/PIK3R2/DNM2	29
KEGG	hsa01212	Fatty acid metabolism	22/2550	57/8135	0.1492	0.3919	0.2976	HADHA/FASN/OXSM/HADH/ACOX1/ECHS1/ELOVL7/ACAA1/MCAT/HSD17B8/ELOVL6/CPT2/ACSL3/ACADVL/TECR/FADS2/MECR/EHHADH/HSD17B12/ACSL5/SCD/ACSL1	22
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	47/2550	131/8135	0.1511	0.3919	0.2976	GRB2/TNFRSF10A/PRKCB/ARAF/KRAS/HCST/VAV1/RAF1/MAPK3/FAS/HLA-A/BRAF/ITGAL/SHC1/ZAP70/HLA-C/PRKCG/SOS2/PTK2B/FYN/IFNAR1/SYK/HLA-G/VAV3/MAP2K2/PIK3CA/FCGR3B/NFATC1/LCP2/MAPK1/KIR2DL5A/IFNA17/RAC3/ULBP2/KIR2DL2/KIR2DS3/RAC2/KIR2DS2/CD244/TYROBP/NFATC2/VAV2/KIR3DL3/HRAS/HLA-E/PIK3R2/PPP3R1	47
KEGG	hsa03060	Protein export	10/2550	23/8135	0.1514	0.3919	0.2976	SRP54/SRP14/SEC11A/SRPRB/SPCS1/SPCS2/SEC61A2/SRP72/OXA1L/IMMP1L	10
KEGG	hsa00260	Glycine, serine and threonine metabolism	16/2550	40/8135	0.1557	0.4001	0.3039	AMT/SRR/GCAT/SHMT2/AOC2/BPGM/CTH/PGAM1/DAO/GATM/PHGDH/AGXT/AOC3/DMGDH/SDS/SHMT1	16
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/2550	26/8135	0.1596	0.4068	0.309	PGAP1/PIGM/PIGA/PIGB/DPM2/PIGX/PIGT/PIGF/PIGP/PIGZ/PIGC	11
KEGG	hsa04930	Type II diabetes mellitus	18/2550	46/8135	0.1628	0.4098	0.3113	MAPK8/MAPK3/SOCS4/IKBKB/CACNA1B/HK1/SOCS1/MAPK9/PIK3CA/PKM/MAPK1/MTOR/INSR/HK3/HKDC1/PRKCZ/SOCS3/PIK3R2	18
KEGG	hsa04912	GnRH signaling pathway	34/2550	93/8135	0.1639	0.4098	0.3113	GRB2/CALM1/PRKCB/MAP2K6/KRAS/MAPK11/MAPK8/RAF1/MAPK3/MAP3K4/ITPR1/PRKACA/GNAS/MAP3K3/CDC42/CAMK2D/MAP2K4/ADCY4/SOS2/PRKACB/PTK2B/MAPK7/PLD2/ITPR3/GNA11/MAP2K2/MAPK9/MAPK1/MAPK13/HBEGF/HRAS/ADCY8/EGR1/MAP2K7	34
KEGG	hsa01240	Biosynthesis of cofactors	54/2550	153/8135	0.1647	0.4098	0.3113	NADK2/LIAS/NME3/COX15/OXSM/NME6/PMM1/NME1/COASY/HMBS/NMNAT1/DHFR/HAAO/VKORC1/ALAD/UGP2/ADSL/AK1/AK2/MTHFD1/AKR1A1/UROD/RFK/AFMID/CPOX/COQ2/SHMT2/PTS/QPRT/AK6/AK9/UGDH/COQ5/RGN/NQO1/PNPO/COX10/GCLM/ALDH3A2/NMNAT3/SPR/DHODH/CTPS1/RDH13/GGCX/PANK3/MAT2A/MTHFD1L/NAPRT/GGH/MMAB/SHMT1/PHOSPHO2/GCH1	54
KEGG	hsa05030	Cocaine addiction	19/2550	49/8135	0.1656	0.4098	0.3113	CREB1/GNAI2/FOSB/RELA/GRIN1/GRIN3B/PRKACA/GNAS/CREB3/CREB3L4/PRKACB/ATF2/CREB3L2/CDK5/RGS9/NFKB1/GNAI1/DDC/SLC6A3	19
KEGG	hsa00061	Fatty acid biosynthesis	8/2550	18/8135	0.1713	0.4166	0.3164	FASN/OXSM/MCAT/HSD17B8/ACSL3/MECR/ACSL5/ACSL1	8
KEGG	hsa00511	Other glycan degradation	8/2550	18/8135	0.1713	0.4166	0.3164	AGA/HEXA/MAN2B1/NEU2/MAN2B2/ENGASE/HEXB/GBA2	8
KEGG	hsa04215	Apoptosis - multiple species	13/2550	32/8135	0.1721	0.4166	0.3164	XIAP/BAX/BECN1/MAPK8/BIRC2/BIRC3/FADD/BAK1/MAPK9/CASP8/BIRC6/DIABLO/BIRC5	13
KEGG	hsa04720	Long-term potentiation	25/2550	67/8135	0.1768	0.4249	0.3227	CALM1/PRKCB/ARAF/KRAS/RAF1/MAPK3/ITPR1/CREBBP/PPP1CB/BRAF/GRIN1/PRKACA/CAMK2D/PRKCG/PRKACB/ITPR3/RPS6KA1/PPP1CA/MAP2K2/RAP1B/RPS6KA2/MAPK1/HRAS/ADCY8/PPP3R1	25
KEGG	hsa05417	Lipid and atherosclerosis	74/2550	215/8135	0.1811	0.4291	0.3259	HSP90B1/BAX/TNFRSF10A/CALM1/HSP90AB1/MAP2K6/KRAS/ATF6/MAPK11/VAV1/MAPK8/TAB1/MAPK3/OLR1/SOD2/FAS/RELA/ITPR1/CHUK/IKBKB/PYCARD/CDC42/CXCL2/POU2F1/MIB1/NFATC3/CAMK2D/NFE2L2/MAP2K4/BAD/MMP9/EIF2AK3/MAP3K7/JAK2/HSPA1L/IKBKG/TBK1/CASP6/SELP/PDPK1/VAV3/ABCG1/POU2F2/MAPK9/NFKB1/PIK3CA/ARHGEF1/HSP90AA1/RAP1B/NFATC1/PTK2/MAPK1/IFNA17/RXRA/IKBKE/CASP8/TAB2/VCAM1/TLR6/MAPK13/CYP2C8/AKT1/ABCA1/TANK/XBP1/NFATC2/VAV2/MIB2/HRAS/CYP2A6/HSPD1/PIK3R2/PPP3R1/MAP2K7	74
KEGG	hsa05418	Fluid shear stress and atherosclerosis	49/2550	139/8135	0.1812	0.4291	0.3259	HSP90B1/BMPR2/CALM1/TXN2/HSP90AB1/MAP2K6/KEAP1/MAPK11/MAPK8/PRKAA1/GSTP1/RELA/CHUK/IKBKB/GSTM5/NFE2L2/MAP2K4/MMP9/MAP3K7/SUMO3/MAPK7/ACVR2A/IKBKG/CTNNB1/SUMO1/NQO1/ACVR2B/MAPK9/NFKB1/PIK3CA/HSP90AA1/PTK2/PIAS4/NPPC/RAC3/CDH5/MGST2/RAC2/VCAM1/VEGFA/MAPK13/GSTA4/AKT1/ITGAV/ITGA2B/PRKCZ/GSTT2/PIK3R2/MAP2K7	49
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	38/2550	106/8135	0.1833	0.431	0.3274	AKAP13/CREB1/PRKCB/ARAF/ARRB1/GNAI2/NR4A2/RAF1/MAPK3/PDE4B/ITPR1/BRAF/PRKACA/GNAS/LRP6/CREB3/CREB3L4/PRKCG/JUND/ADCY4/PRKACB/ATF2/PLD2/ITPR3/CREB3L2/GNA11/ARHGEF1/MAPK1/GNAI1/RXRA/CDKN1A/GNA13/ARHGEF11/MEF2D/HBEGF/ADCY8/PDE4A/EGR1	38
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/2550	24/8135	0.19	0.4438	0.3371	EXTL3/NDST1/EXT1/HS3ST3B1/B3GAT3/EXTL2/B3GALT6/NDST3/XYLT2/GLCE	10
KEGG	hsa04310	Wnt signaling pathway	58/2550	167/8135	0.1919	0.4451	0.3381	PRKCB/SENP2/DVL3/CSNK2A1/SERPINF1/NLK/MAPK8/CTBP1/FZD6/FZD2/CREBBP/SIAH1/PRKACA/CCND2/CTNND2/LRP6/BAMBI/RYK/CACYBP/CSNK1A1/NFATC3/CAMK2D/RNF43/TBL1X/PRKCG/MAP3K7/PRKACB/FZD1/PPARD/INVS/CTNNB1/SFRP4/RUVBL1/CTNNBIP1/FRAT2/FBXW11/WNT8B/MAPK9/PORCN/NFATC1/TBL1XR1/CSNK1E/RAC3/DVL2/CSNK2B/WNT2B/RAC2/ROR2/WNT11/TBL1Y/SKP1/WNT1/LGR4/CXXC4/LGR6/NFATC2/FZD9/PPP3R1	58
KEGG	hsa05226	Gastric cancer	52/2550	149/8135	0.1956	0.4506	0.3422	GRB2/BAX/ARAF/DVL3/KRAS/RAF1/MAPK3/FZD6/RPS6KB1/FZD2/BRAF/DDB2/LRP6/SHC1/TGFBR2/CSNK1A1/SOS2/FZD1/TGFBR1/GADD45A/CTNNB1/BAK1/FRAT2/WNT8B/MAP2K2/PIK3CA/POLK/MAPK1/E2F3/MTOR/DVL2/RPS6KB2/RXRA/WNT2B/FGF10/WNT11/CCNE2/CDKN1A/WNT1/AKT1/MLH1/FGF3/CTNNA1/FGF16/EGF/ABCB1/HRAS/CDH1/PIK3R2/FZD9/HGF/SHH	52
KEGG	hsa04510	Focal adhesion	69/2550	201/8135	0.1981	0.4531	0.3442	GRB2/XIAP/PRKCB/DIAPH1/VAV1/MAPK8/RAF1/MAPK3/PPP1CB/BRAF/THBS1/CRK/BIRC2/PPP1R12A/THBS3/CCND2/ARHGAP35/THBS4/CDC42/SHC1/FLNA/COL1A1/BIRC3/MYL7/PRKCG/MYL12B/BAD/SOS2/FYN/COL2A1/CTNNB1/FLT4/PPP1CA/COMP/RELN/PDPK1/VAV3/TNN/MAPK9/PIK3CA/RAP1B/ITGA11/PTK2/MAPK1/ITGA5/RAC3/PAK2/RAC2/VASP/VEGFA/FLNB/ITGA3/ITGA9/ITGB5/AKT1/COL9A2/ITGAV/ITGA2B/PGF/VAV2/EGF/CHAD/HRAS/COL1A2/ITGB1/MYLPF/COL4A2/PIK3R2/HGF	69
KEGG	hsa04725	Cholinergic synapse	40/2550	113/8135	0.2014	0.4574	0.3474	GNB1/CREB1/PRKCB/PIK3CG/KRAS/GNAI2/MAPK3/ITPR1/PRKACA/CREB3/CACNA1B/CAMK2D/CREB3L4/ACHE/PRKCG/PIK3R5/ADCY4/JAK2/PRKACB/GNG11/KCNQ4/GNG8/ITPR3/FYN/CREB3L2/GNA11/GNB4/PIK3CA/MAPK1/GNAI1/CHRNA6/CHRM4/GNG3/GNGT2/CHRNA3/AKT1/HRAS/GNB2/ADCY8/PIK3R2	40
KEGG	hsa05171	Coronavirus disease - COVID-19	79/2550	232/8135	0.2027	0.4574	0.3474	IL6R/PRKCB/RPL26L1/RPS9/RPL8/IRF9/IL6ST/TYK2/MAPK11/MAPK8/RPL37A/MAPK3/RELA/FAU/CHUK/IKBKB/RPS15A/RPS6/RPL12/RPS16/C9/RPLP0/RPS10/RPL15/RPS24/RPL35/RPS18/PRKCG/MAP3K7/IKBKG/TBK1/UBA52/IFNAR1/SYK/C1R/FGB/RPS27/SELP/RPL39/RPS7/RPL29/RPS5/C6/RPS15/MAPK9/NFKB1/ADAR/PIK3CA/RPL35A/C1QA/CFD/RPL19/MAPK1/MAVS/IFNA17/FGG/IKBKE/TAB2/RPS4X/RPL36/RPL14/MAPK13/RPS19/F2/RPL10A/RPLP2/RPL41/RPL10L/RPL6/MBL2/AGTR1/RPL23A/HBEGF/CFB/RPS21/RPL18/RPL32/PIK3R2/OAS2	79
KEGG	hsa04130	SNARE interactions in vesicular transport	13/2550	33/8135	0.2066	0.4631	0.3517	USE1/VAMP8/STX6/STX8/SNAP29/BET1/YKT6/STX5/VAMP4/GOSR2/SNAP23/BNIP1/STX1B	13
KEGG	hsa04728	Dopaminergic synapse	46/2550	132/8135	0.2164	0.4793	0.364	GNB1/PPP2R1A/CREB1/CALM1/PRKCB/ARRB1/GNAI2/MAPK11/MAPK8/KIF5B/ITPR1/PPP1CB/ARNTL/PRKACA/GNAS/PPP2R3C/CREB3/PPP2R2A/CACNA1B/CAMK2D/CREB3L4/PRKCG/PRKACB/ATF2/GNG11/GNG8/PPP2R5E/ITPR3/CREB3L2/PPP1CA/PPP2R2D/GNB4/MAPK9/PPP2R5D/GNAI1/DDC/SLC6A3/GNG3/GNGT2/MAPK13/COMT/AKT1/KIF5A/GNB2/PPP2CA/CLOCK	46
KEGG	hsa03022	Basal transcription factors	17/2550	45/8135	0.2179	0.4793	0.364	TAF12/TAF2/GTF2H4/TAF9B/TBP/CDK7/ERCC2/TAF8/TAF3/TAF5/GTF2F1/GTF2H3/TAF1/GTF2E2/TAF4B/TAF10/GTF2F2	17
KEGG	hsa00280	Valine, leucine and isoleucine degradation	18/2550	48/8135	0.2196	0.4793	0.364	HADHA/ALDH6A1/HSD17B10/MCEE/BCKDHA/PCCB/HADH/ECHS1/HMGCS1/ACAA1/MCCC2/ALDH9A1/ACAD8/ALDH3A2/EHHADH/BCKDHB/AACS/HMGCL	18
KEGG	hsa04670	Leukocyte transendothelial migration	40/2550	114/8135	0.2205	0.4793	0.364	PRKCB/GNAI2/MAPK11/VAV1/EZR/ITGAL/ARHGAP35/CDC42/MYL7/PRKCG/MYL12B/MMP9/CXCR4/PTK2B/RASSF5/CTNNB1/CLDN2/MSN/VAV3/PIK3CA/RAP1B/SIPA1/PTK2/GNAI1/CDH5/RAC2/TXK/VCAM1/VASP/CLDN5/MAPK13/F11R/CD99L2/CTNNA1/VAV2/ITGB1/CLDN6/MYLPF/PIK3R2/OCLN	40
KEGG	hsa00270	Cysteine and methionine metabolism	19/2550	51/8135	0.2211	0.4793	0.364	AHCY/AHCYL1/MDH2/MDH1/SRM/GOT2/DNMT3A/TST/MPST/GCLM/MTAP/CTH/MAT2A/ENOPH1/MTR/PHGDH/BHMT2/SDS/ADI1	19
KEGG	hsa05142	Chagas disease	36/2550	102/8135	0.2227	0.4793	0.364	PPP2R1A/GNAI2/MAPK11/MAPK8/MAPK3/CFLAR/FAS/RELA/GNAS/CALR/CHUK/IKBKB/PPP2R2A/TGFBR2/FADD/MAP2K4/TGFBR1/IKBKG/PPP2R2D/GNA11/CD3G/IL10/MAPK9/NFKB1/PIK3CA/C1QA/MAPK1/CD3D/GNAI1/CASP8/TLR6/MAPK13/AKT1/TLR9/PIK3R2/PPP2CA	36
KEGG	hsa04730	Long-term depression	22/2550	60/8135	0.2239	0.4793	0.364	PPP2R1A/PRKCB/ARAF/KRAS/GNAI2/RAF1/MAPK3/ITPR1/BRAF/GNAS/PRKCG/CRHR1/ITPR3/GNA11/MAP2K2/MAPK1/NOS1/GNAI1/GNA13/GNAZ/HRAS/PPP2CA	22
KEGG	hsa04919	Thyroid hormone signaling pathway	42/2550	121/8135	0.2386	0.5033	0.3823	MED27/PRKCB/KRAS/RAF1/MAPK3/PLCD1/CREBBP/PRKACA/NCOR1/RCAN1/HDAC3/MED12/MDM2/KAT2B/PRKCG/BAD/HIF1A/PRKACB/MED1/CTNNB1/DIO3/PDPK1/MED17/MYH7/THRB/NCOA2/MAP2K2/PIK3CA/MAPK1/MTOR/RXRA/ATP1B1/ATP2A2/AKT1/FXYD2/ITGAV/HDAC1/MED4/HRAS/PIK3R2/HDAC2/SIN3A	42
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2550	11/8135	0.2407	0.5033	0.3823	VKORC1/COQ2/COQ5/NQO1/GGCX	5
KEGG	hsa00410	beta-Alanine metabolism	12/2550	31/8135	0.2409	0.5033	0.3823	HADHA/ALDH6A1/ACOX1/ECHS1/CARNS1/AOC2/ALDH3B2/ALDH9A1/ALDH3A2/EHHADH/AOC3/CNDP2	12
KEGG	hsa04066	HIF-1 signaling pathway	38/2550	109/8135	0.2422	0.5033	0.3823	VHL/IL6R/PRKCB/MAPK3/RPS6KB1/RELA/CREBBP/EGLN1/RPS6/PGK1/HK1/CAMK2D/PRKCG/ENO2/HIF1A/MKNK1/EIF4E2/EIF4EBP1/MAP2K2/NFKB1/PIK3CA/PDHB/MAPK1/MTOR/RPS6KB2/INSR/CUL2/GAPDH/VEGFA/CDKN1A/AKT1/HK3/HKDC1/EGF/EGLN3/EIF4E/PIK3R2/ALDOA	38
KEGG	hsa04934	Cushing syndrome	53/2550	155/8135	0.2452	0.5033	0.3823	CREB1/PDE8A/DVL3/FH/GNAI2/MAPK3/USP8/FZD6/FZD2/ITPR1/BRAF/PRKACA/GNAS/KMT2A/WDR5/CREB3/CDKN2C/CAMK2D/CREB3L4/ADCY4/PRKACB/FZD1/RASD1/STAR/ATF2/CDK6/CRHR1/AIP/ITPR3/CREB3L2/CTNNB1/CDK4/GNA11/WNT8B/MAP2K2/RAP1B/PBX1/MAPK1/E2F3/CDKN2A/GNAI1/DVL2/WNT2B/WNT11/CCNE2/SCARB1/CDKN1A/WNT1/AIPL1/RBBP5/AGTR1/ADCY8/FZD9	53
KEGG	hsa04070	Phosphatidylinositol signaling system	34/2550	97/8135	0.2456	0.5033	0.3823	CALM1/PRKCB/DGKH/SACM1L/PIK3C2A/INPP5A/IPPK/DGKD/PIP4K2B/PLCD1/ITPR1/PIP4K2A/SYNJ1/DGKA/PPIP5K1/MTMR6/MTMR14/PRKCG/IMPA1/PIP4K2C/MTMR1/INPP5D/ITPR3/DGKQ/PIK3CA/INPP5E/MTMR2/PIK3C3/INPPL1/PI4KB/MTM1/MTMR7/PIK3R2/PI4K2A	34
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	34/2550	97/8135	0.2456	0.5033	0.3823	WASF2/ACTR2/ARPC1B/PRKCB/VAV1/RAF1/MAPK3/RPS6KB1/CRK/ARPC3/CDC42/ASAP1/CFL1/PRKCG/PTPRC/INPP5D/PLD2/SYK/SPHK2/VAV3/PIK3CA/FCGR3B/MAPK1/ARPC4/RPS6KB2/RAC2/VASP/AKT1/INPPL1/WASF3/VAV2/SPHK1/PIK3R2/DNM2	34
KEGG	hsa04622	RIG-I-like receptor signaling pathway	25/2550	70/8135	0.2513	0.5118	0.3887	PIN1/MAPK11/MAPK8/RELA/RIPK1/CHUK/IKBKB/ATG12/FADD/DDX3X/MAP3K7/IKBKG/TBK1/SIKE1/MAPK9/NFKB1/MAVS/NLRX1/IFNA17/IKBKE/CASP8/TRADD/MAPK13/TANK/TRIM25	25
KEGG	hsa04722	Neurotrophin signaling pathway	41/2550	119/8135	0.2599	0.5261	0.3996	GRB2/BAX/CALM1/KRAS/MAPK11/MAPK8/RAF1/MAPK3/RELA/BRAF/CRK/NGF/IKBKB/MAP3K3/CDC42/SHC1/CAMK2D/BAD/SOS2/MAPK7/RPS6KA1/PDPK1/MAP2K2/MAPK9/NFKB1/PIK3CA/RAP1B/RPS6KA2/MAPK1/SORT1/KIDINS220/ABL1/SH2B3/MAPK13/AKT1/FOXO3/MAPKAPK2/SH2B1/HRAS/PIK3R2/MAP2K7	41
KEGG	hsa00450	Selenocompound metabolism	7/2550	17/8135	0.2637	0.5306	0.403	SEPSECS/PAPSS1/SEPHS2/PAPSS2/CTH/MTR/SCLY	7
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/2550	20/8135	0.2702	0.5404	0.4105	CHPF2/CHSY3/B3GAT3/CHST13/CSGALNACT2/B3GALT6/XYLT2/CHST7	8
KEGG	hsa00790	Folate biosynthesis	10/2550	26/8135	0.2781	0.553	0.42	DHFR/PCBD2/CBR1/QDPR/PTS/AKR1B1/SPR/GGH/TPH1/GCH1	10
KEGG	hsa04340	Hedgehog signaling pathway	20/2550	56/8135	0.2829	0.5591	0.4247	CSNK1G1/CUL3/MEGF8/ARRB1/SPOP/PRKACA/CCND2/CSNK1A1/PRKACB/CSNK1D/PTCH2/FBXW11/SMURF2/CSNK1E/IQCE/DISP1/GAS1/HHAT/EVC/SHH	20
KEGG	hsa04936	Alcoholic liver disease	48/2550	142/8135	0.2902	0.5701	0.433	FASN/TRA2B/MAP2K6/PRKAG1/SIRT1/MAPK11/MAPK8/TAB1/PRKAA1/FAS/ADIPOR1/RELA/RIPK1/CHUK/ACOX1/IKBKB/PPARA/CXCL2/FADD/MAP2K4/MAP3K7/SREBF1/IKBKG/TBK1/IL17RC/TAB3/CTNNB1/LPIN3/ALDH9A1/MAPK9/NFKB1/C1QA/IL17RA/ALDH3A2/ACADVL/IFNA17/IKBKE/CASP8/TAB2/TRADD/PPARGC1A/ADH5/MAPK13/FABP1/AKT1/FOXO3/SCD/MAP2K7	48
KEGG	hsa04612	Antigen processing and presentation	27/2550	78/8135	0.3038	0.5933	0.4506	CREB1/HSP90AB1/TAP2/HLA-A/B2M/CALR/RFXANK/PSME1/HLA-C/HLA-DPB1/HSPA1L/HLA-DPA1/PSME3/LGMN/HLA-G/TAPBP/HLA-DOA/HSP90AA1/KIR2DL5A/KIR2DL2/CTSB/KIR2DS3/KIR2DS2/NFYA/HLA-DOB/KIR3DL3/HLA-E	27
KEGG	hsa04920	Adipocytokine signaling pathway	24/2550	69/8135	0.3087	0.5995	0.4554	PRKAG1/MAPK8/PRKAA1/ADIPOR1/RELA/CHUK/IKBKB/PPARA/JAK2/TNFRSF1B/ACSL3/IKBKG/LEPR/MAPK9/NFKB1/MTOR/RXRA/TRADD/PPARGC1A/AKT1/PCK2/ACSL5/ACSL1/SOCS3	24
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	34/2550	100/8135	0.3166	0.6016	0.4569	BAX/PRKCB/DIAPH1/KRAS/MAPK11/MAPK8/MAPK3/PLCD1/RELA/CDC42/COL1A1/TGFBR2/JAK2/TGFBR1/CDK4/F3/MAPK9/NFKB1/PIK3CA/NFATC1/STAT5A/MAPK1/VCAM1/VEGFA/MAPK13/AKT1/STAT5B/AGTR1/HRAS/COL1A2/PRKCZ/COL4A2/PIK3R2/EGR1	34
KEGG	hsa04630	JAK-STAT signaling pathway	54/2550	162/8135	0.3181	0.6016	0.4569	IL6R/GRB2/IRF9/IL6ST/TYK2/IL27RA/RAF1/PIAS3/LIF/SOCS4/STAT4/SOCS7/IL4R/CREBBP/IL11RA/CCND2/PIAS2/IL7/JAK2/SOS2/MCL1/SOCS1/IFNAR1/IL2RB/GH1/IL10/LEPR/PIK3CA/STAT5A/PTPN2/PIAS4/IFNA17/MTOR/IL9/OSM/IL21R/CDKN1A/IL20RB/AKT1/STAT5B/IL13RA2/JAK3/IL11/IL20/IL13/EGF/FHL1/HRAS/SOCS3/CSH1/IL13RA1/PIK3R2/IL15/IL17D	54
KEGG	hsa00330	Arginine and proline metabolism	18/2550	51/8135	0.3183	0.6016	0.4569	HOGA1/CARNS1/AGMAT/ARG1/ARG2/SRM/GOT2/ALDH9A1/ALDH3A2/NOS1/DAO/SAT1/GATM/AZIN2/ODC1/CKB/CKM/CNDP2	18
KEGG	hsa04350	TGF-beta signaling pathway	32/2550	94/8135	0.3208	0.6016	0.4569	PPP2R1A/BMPR2/MAPK3/RPS6KB1/CREBBP/THBS1/TGIF1/BAMBI/TGFBR2/TGIF2/ACVR2A/TGFBR1/HAMP/ID1/INHBB/SMAD5/INHBA/NOG/ACVR2B/FMOD/SMURF2/MAPK1/BMP7/RPS6KB2/SKP1/LEFTY1/NEO1/NBL1/LTBP1/SMAD7/PPP2CA/ZFYVE16	32
KEGG	hsa00230	Purine metabolism	43/2550	128/8135	0.3208	0.6016	0.4569	PDE8A/ITPA/GMPR2/NME3/DGUOK/HDDC3/NME6/APRT/NME1/PDE4B/HDDC2/ADSL/AK1/AK2/PRPS2/PDE6D/NTPCR/ADCY4/AK6/AK9/RRM2B/IMPDH2/PAPSS1/NUDT9/ATIC/PAPSS2/NUDT2/RRM1/NUDT5/HPRT1/PGM2/PDE1A/ALLC/IMPDH1/ADPRM/AMPD3/PDE3B/PFAS/ENPP4/ADCY8/PDE6C/PRPS1L1/PDE4A	43
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	70/2550	212/8135	0.3214	0.6016	0.4569	GRB2/HSP90B1/XIAP/CREB1/PRKCB/HSP90AB1/ARRB1/KRAS/GNAI2/RAF1/MAPK3/RPS6KB1/KPNA2/RELA/PRKACA/GNAS/PAQR7/GSTM5/CREB3/PPARA/CACNA1B/KPNB1/CREB3L4/PRKCG/BAD/ADCY4/JAK2/SOS2/DLL1/PRKACB/ATF2/AIP/MIRLET7D/RPS6KA1/CREB3L2/EIF4EBP1/MAP2K2/NFKB1/PIK3CA/HSP90AA1/RPS6KA2/STAT5A/MAPK1/PAQR8/GNAI1/MTOR/MGST2/RPS6KB2/RXRA/FGF10/IKBKE/VEGFA/KPNA1/CYP1B1/GSTA4/CHRNA3/WNT1/AKT1/STAT5B/AIPL1/FGF3/FGF16/EGF/HRAS/GSTT2/BIRC5/ADCY8/ADRB1/PIK3R2/KPNA5	70
KEGG	hsa00380	Tryptophan metabolism	15/2550	42/8135	0.3224	0.6016	0.4569	HADHA/DHTKD1/HAAO/HADH/ECHS1/AFMID/ALDH9A1/CAT/ALDH3A2/DDC/DLST/CYP1B1/EHHADH/TPH1/GCDH	15
KEGG	hsa00051	Fructose and mannose metabolism	12/2550	33/8135	0.3254	0.6038	0.4586	SORD/PMM1/TSTA3/HK1/KHK/TPI1/AKR1B1/HK3/HKDC1/FBP1/GMDS/ALDOA	12
KEGG	hsa04916	Melanogenesis	34/2550	101/8135	0.3416	0.6304	0.4788	CREB1/CALM1/PRKCB/DVL3/KRAS/GNAI2/RAF1/MAPK3/FZD6/FZD2/CREBBP/PRKACA/GNAS/CREB3/CAMK2D/CREB3L4/PRKCG/ADCY4/PRKACB/FZD1/CREB3L2/CTNNB1/ASIP/WNT8B/MAP2K2/MAPK1/GNAI1/DVL2/WNT2B/WNT11/WNT1/HRAS/ADCY8/FZD9	34
KEGG	hsa04520	Adherens junction	24/2550	71/8135	0.3694	0.6778	0.5148	WASF2/CSNK2A1/NLK/MAPK3/WASL/IQGAP1/CREBBP/CDC42/TGFBR2/YES1/MAP3K7/ACP1/SSX2IP/TGFBR1/FYN/CTNNB1/MAPK1/RAC3/INSR/CSNK2B/RAC2/WASF3/CTNNA1/CDH1	24
KEGG	hsa04710	Circadian rhythm	11/2550	31/8135	0.3727	0.6801	0.5166	CREB1/PRKAG1/PRKAA1/ARNTL/CSNK1D/FBXW11/CSNK1E/SKP1/BHLHE40/CRY1/CLOCK	11
KEGG	hsa04260	Cardiac muscle contraction	29/2550	87/8135	0.3827	0.6916	0.5253	COX7A2L/UQCRFS1/COX1/COX8A/UQCRQ/COX5A/COX6B1/COX5B/UQCR10/CYC1/UQCR11/CACNA2D3/COX6A1/CACNG1/TPM3/MYH7/RYR2/COX7B/CACNB2/UQCRC2/ATP1B1/COX7C/ATP2A2/COX4I1/TNNC1/FXYD2/CACNG7/COX8C/CACNB4	29
KEGG	hsa05145	Toxoplasmosis	37/2550	112/8135	0.3833	0.6916	0.5253	XIAP/MAP2K6/PIK3CG/GNAI2/TYK2/MAPK11/MAPK8/TAB1/MAPK3/RELA/CHUK/BIRC2/IKBKB/BIRC3/HLA-DPB1/PIK3R5/BAD/MAP3K7/JAK2/HSPA1L/IKBKG/HLA-DPA1/SOCS1/PDPK1/IL10/MAPK9/HLA-DOA/NFKB1/MAPK1/GNAI1/CASP8/TAB2/MAPK13/AKT1/HLA-DOB/ITGB1/CCR5	37
KEGG	hsa00360	Phenylalanine metabolism	6/2550	16/8135	0.3852	0.6916	0.5253	MIF/GOT2/AOC2/ALDH3B2/DDC/AOC3	6
KEGG	hsa04114	Oocyte meiosis	43/2550	131/8135	0.3885	0.6939	0.527	PPP2R1A/CALM1/REC8/ANAPC16/MAPK11/YWHAB/MAPK3/ANAPC11/ITPR1/PPP1CB/PRKACA/ANAPC4/SPDYE2/CDC26/SMC3/MAD2L2/CAMK2D/YWHAZ/SMC1A/ADCY4/PRKACB/PPP2R5E/ITPR3/RPS6KA1/PPP1CA/CCNB2/FBXW11/YWHAQ/SLK/PPP2R5D/RPS6KA2/MAPK1/ANAPC7/MAD2L1/CDC20/SKP1/CCNE2/MAPK13/MOS/ANAPC15/ADCY8/PPP3R1/PPP2CA	43
KEGG	hsa04721	Synaptic vesicle cycle	26/2550	78/8135	0.3931	0.6953	0.5281	ATP6V1G1/ATP6V1D/NAPA/ATP6V1E2/TCIRG1/CACNA1B/SLC32A1/AP2B1/AP2S1/SLC6A7/ATP6V0A2/RAB3A/ATP6V0B/CLTA/SLC6A3/ATP6V0D2/SLC6A4/CLTC/ATP6V1H/AP2A2/ATP6V1E1/CLTB/SYT1/DNM3/DNM2/STX1B	26
KEGG	hsa05110	Vibrio cholerae infection	17/2550	50/8135	0.3935	0.6953	0.5281	ATP6V1G1/PDIA4/ATP6V1D/PRKACA/GNAS/SEC61A2/ATP6V1E2/TCIRG1/SLC12A2/PRKACB/ATP6V0A2/ATP6V0B/ATP6V0D2/KDELR1/TJP2/ATP6V1H/ATP6V1E1	17
KEGG	hsa05224	Breast cancer	48/2550	147/8135	0.3955	0.6953	0.5281	GRB2/BAX/ARAF/DVL3/KRAS/RAF1/MAPK3/FZD6/RPS6KB1/FZD2/BRAF/DDB2/LRP6/SHC1/CSNK1A1/SOS2/DLL1/FZD1/CDK6/GADD45A/CTNNB1/FLT4/BAK1/CDK4/FRAT2/HES5/WNT8B/MAP2K2/PIK3CA/POLK/NFKB2/MAPK1/E2F3/MTOR/DVL2/RPS6KB2/WNT2B/FGF10/WNT11/CDKN1A/WNT1/AKT1/FGF3/FGF16/EGF/HRAS/PIK3R2/FZD9	48
KEGG	hsa05031	Amphetamine addiction	23/2550	69/8135	0.4044	0.706	0.5362	CREB1/CALM1/PRKCB/SIRT1/FOSB/PPP1CB/GRIN1/GRIN3B/PRKACA/GNAS/CREB3/CAMK2D/CREB3L4/PRKCG/PRKACB/ATF2/CREB3L2/PPP1CA/DDC/SLC6A3/HDAC1/HDAC2/PPP3R1	23
KEGG	hsa04216	Ferroptosis	14/2550	41/8135	0.4058	0.706	0.5362	GPX4/VDAC2/PCBP2/LPCAT3/ACSL3/GCLM/VDAC3/SAT1/ACSL5/ALOX15/ACSL1/STEAP3/MAP1LC3B2/PCBP1	14
KEGG	hsa04623	Cytosolic DNA-sensing pathway	21/2550	63/8135	0.4126	0.714	0.5423	POLR2F/POLR3H/POLR2H/RELA/RIPK1/CHUK/IKBKB/POLR3K/PYCARD/POLR3F/POLR2L/IKBKG/TBK1/POLR2E/POLR1C/NFKB1/ADAR/MAVS/POLR1D/IFNA17/IKBKE	21
KEGG	hsa01232	Nucleotide metabolism	28/2550	85/8135	0.415	0.7142	0.5424	ITPA/GMPR2/TK2/NME3/DGUOK/NME6/APRT/NME1/DCTPP1/HDDC2/ADSL/AK1/AK2/NTPCR/AK6/AK9/RRM2B/IMPDH2/RRM1/CTPS1/HPRT1/IMPDH1/TYMS/AMPD3/NT5C3A/TK1/DTYMK/UCKL1	28
KEGG	hsa05416	Viral myocarditis	20/2550	60/8135	0.4169	0.7142	0.5424	EIF4G1/HLA-A/ITGAL/HLA-C/HLA-DPB1/DAG1/HLA-DPA1/FYN/CD55/HLA-G/CD86/MYH7/HLA-DOA/RAC3/CASP8/RAC2/ABL1/HLA-DOB/HLA-E/ABL2	20
KEGG	hsa04620	Toll-like receptor signaling pathway	34/2550	104/8135	0.4193	0.7144	0.5426	MAP2K6/CTSK/MAPK11/MAPK8/TAB1/MAPK3/RELA/RIPK1/CHUK/IKBKB/FADD/MAP2K4/MAP3K7/TLR5/IKBKG/TBK1/IFNAR1/CD86/MAP2K2/MAPK9/NFKB1/PIK3CA/MAPK1/IFNA17/IKBKE/CASP8/TAB2/TLR6/MAPK13/AKT1/TLR9/TOLLIP/PIK3R2/MAP2K7	34
KEGG	hsa05164	Influenza A	55/2550	171/8135	0.4367	0.7404	0.5624	SLC25A6/BAX/TNFRSF10A/PRKCB/DNAJC3/NXF1/IRF9/TYK2/PABPN1/RAF1/MAPK3/SLC25A5/FAS/KPNA2/RELA/CREBBP/NUP98/CHUK/IKBKB/PYCARD/FADD/HLA-DPB1/FDPS/JAK2/CDK6/CPSF4/IKBKG/HLA-DPA1/TBK1/IFNAR1/BAK1/CDK4/PRSS2/MAP2K2/PRSS3/HLA-DOA/NFKB1/ADAR/PIK3CA/MAPK1/MAVS/NLRX1/IFNA17/IKBKE/CASP8/TRADD/KPNA1/AKT1/HLA-DOB/TRIM25/SOCS3/NXT1/PIK3R2/OAS2/KPNA5	55
KEGG	hsa04929	GnRH secretion	21/2550	64/8135	0.4463	0.7501	0.5697	PRKCB/ARRB1/KRAS/RAF1/MAPK3/ITPR1/PRKCG/GABBR1/ITPR3/GNA11/MAP2K2/PIK3CA/MAPK1/HCN2/KCNN1/AKT1/TRPC1/HRAS/KISS1R/HCN3/PIK3R2	21
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	46/2550	143/8135	0.4469	0.7501	0.5697	GRB2/BMPR2/DVL3/KRAS/IL6ST/MAPK11/RAF1/MAPK3/LIF/FZD6/FZD2/MEIS1/REST/JAK2/FZD1/ACVR2A/ISL1/ID1/CTNNB1/INHBB/SMAD5/INHBA/ACVR2B/WNT8B/MAP2K2/PIK3CA/MAPK1/HOXD1/DVL2/WNT2B/MYF5/WNT11/KAT6A/MAPK13/WNT1/AKT1/LEFTY1/PCGF5/JAK3/PCGF2/SMARCAD1/HRAS/JARID2/PIK3R2/FZD9/PCGF3	46
KEGG	hsa04726	Serotonergic synapse	37/2550	115/8135	0.4587	0.7661	0.5819	GNB1/PRKCB/ARAF/KRAS/GNAI2/RAF1/MAPK3/HTR7/ITPR1/BRAF/PRKACA/GNAS/HTR2B/CACNA1B/PRKCG/PRKACB/GNG11/GNG8/ITPR3/HTR4/GNB4/HTR1F/MAPK1/PTGS2/GNAI1/ALOX12/DDC/GNG3/GNGT2/CYP2C8/TRPC1/ALOX15/SLC6A4/TPH1/HRAS/GNB2/HTR1B	37
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	35/2550	109/8135	0.4674	0.7767	0.59	XRN1/GNL3L/WDR75/NXF1/NHP2/CSNK2A1/HEATR1/GTPBP4/RBM28/RPP25L/RRP7A/POP7/RPP25/RIOK1/NOP58/LSG1/FBL/RPP40/UTP15/IMP3/AK6/POP5/UTP14A/FCF1/RPP38/CSNK2B/GNL2/RPP30/GAR1/WDR36/EMG1/EIF6/NXT1/NOB1/RAN	35
KEGG	hsa04966	Collecting duct acid secretion	9/2550	27/8135	0.4835	0.7995	0.6073	ATP6V1G1/ATP6V1D/ATP6V1E2/TCIRG1/CA2/ATP6V0A2/ATP6V0D2/ATP6V1E1/SLC12A7	9
KEGG	hsa05131	Shigellosis	78/2550	247/8135	0.4926	0.8101	0.6153	WASF2/ACTR2/ARPC1B/BAX/DIAPH1/BECN1/ELMO2/MAPK11/MAPK8/GLMN/TAB1/MAPK3/WASL/PLCD1/RPS6KB1/RELA/ITPR1/RIPK1/CRK/CHUK/ARPC3/IKBKB/PYCARD/CAPNS1/CDC42/ATG12/CYTH4/HK1/CAST/UBE2D2/MDM2/MYL7/MYL12B/MAP3K7/U2AF1/TLR5/CTTN/IKBKG/ITPR3/TBK1/UBA52/NAIP/TAB3/TRAF5/FBXW11/MAPK9/NFKB1/PIK3CA/ATG14/CASP4/PTK2/MAPK1/NOD1/ITGA5/ARPC4/ELMO1/FOXO4/MTOR/RPS6KB2/UBC/PIK3C3/TAB2/TRADD/PFN1/RRAGA/SKP1/MAPK13/AKT1/HK3/FOXO3/HKDC1/BNIP3/CAPN1/ITGB1/SHARPIN/MYLPF/PIK3R2/MAP1LC3B2	78
KEGG	hsa03320	PPAR signaling pathway	24/2550	75/8135	0.4948	0.8101	0.6153	OLR1/SLC27A5/ACOX1/PPARA/HMGCS1/ACAA1/CPT2/ACSL3/PPARD/SLC27A1/PDPK1/NR1H3/UBC/RXRA/FABP5/FADS2/DBI/SLC27A6/EHHADH/FABP1/PCK2/ACSL5/SCD/ACSL1	24
KEGG	hsa04922	Glucagon signaling pathway	34/2550	107/8135	0.4983	0.8118	0.6166	CRTC2/CREB1/CALM1/PRKAG1/SIRT1/PRMT1/PRKAA1/ITPR1/CREBBP/PRKACA/GNAS/CREB3/PPARA/SIK1/GYS2/CAMK2D/CREB3L4/PRKACB/PHKG1/ATF2/ITPR3/CREB3L2/PDHB/PKM/PGAM1/PYGM/PPARGC1A/SIK2/AKT1/PCK2/FBP1/PDE3B/PPP4C/PPP3R1	34
KEGG	hsa04540	Gap junction	28/2550	88/8135	0.5021	0.8142	0.6184	GRB2/PRKCB/KRAS/GNAI2/RAF1/MAPK3/ITPR1/PRKACA/GNAS/HTR2B/PRKCG/ADCY4/SOS2/PRKACB/CSNK1D/MAPK7/ITPR3/GNA11/MAP2K2/MAPK1/GNAI1/TUBA1B/TUBB1/EGF/HRAS/ADCY8/TUBA4A/ADRB1	28
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	12/2550	37/8135	0.505	0.8148	0.6189	PRKCB/KRAS/MAPK3/PRKCG/PDPK1/PIK3CA/MAPK1/SCNN1G/INSR/ATP1B1/FXYD2/PIK3R2	12
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2550	15/8135	0.5304	0.8429	0.6402	ST3GAL1/HEXA/ST3GAL2/NAGA/HEXB	5
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/2550	15/8135	0.5304	0.8429	0.6402	ST3GAL1/HEXA/ST3GAL2/B3GALT4/HEXB	5
KEGG	hsa00730	Thiamine metabolism	5/2550	15/8135	0.5304	0.8429	0.6402	AK1/AK2/NTPCR/ACP1/THTPA	5
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	47/2550	150/8135	0.5325	0.8429	0.6402	PPP2R1A/CREB1/CALM1/PIK3CG/GNAI2/MAPK11/MAPK3/PPP1CB/CACNA2D3/PRKACA/GNAS/PPP2R3C/CREB3/PPP2R2A/CAMK2D/CREB3L4/PIK3R5/ADCY4/CACNG1/PRKACB/ATF2/PPP2R5E/CREB3L2/PPP1CA/PPP2R2D/TPM3/MYH7/PPP2R5D/RYR2/MAPK1/GNAI1/CACNB2/ATP1B1/ATP2A2/MAPK13/TNNC1/AKT1/SCN1B/FXYD2/CACNG7/AGTR1/ADCY8/CACNB4/ADRB1/CREM/PPP2CA/KCNE1	47
KEGG	hsa04024	cAMP signaling pathway	69/2550	221/8135	0.5419	0.8538	0.6485	CREB1/CALM1/GNAI2/VAV1/MAPK8/RAF1/MAPK3/RELA/PDE4B/CREBBP/PPP1CB/BRAF/GRIN1/GRIN3B/PRKACA/GNAS/ACOX1/PPP1R12A/CREB3/PPARA/OXTR/CAMK2D/CREB3L4/GIPR/GABBR1/BAD/ADCY4/PRKACB/TIAM1/CRHR1/PLD2/CREB3L2/PPP1CA/HTR4/VAV3/HTR1F/MAP2K2/MAPK9/NFKB1/RRAS/PIK3CA/RAP1B/NFATC1/RYR2/MAPK1/RAC3/GNAI1/RRAS2/ATP1B1/RAC2/ATP2A2/HCN2/AKT1/FXYD2/F2R/LIPE/VAV2/SST/PDE3B/SSTR1/CNGA4/ADCY8/VIP/GHSR/OXT/ADRB1/PIK3R2/HTR1B/PDE4A	69
KEGG	hsa04390	Hippo signaling pathway	49/2550	157/8135	0.5452	0.8549	0.6494	PPP2R1A/BMPR2/PRKCI/DVL3/AREG/YWHAB/FZD6/FZD2/SCRIB/PPP1CB/BIRC2/LIMD1/CCND2/PPP2R2A/TGFBR2/MOB1A/BIRC3/YWHAZ/FZD1/CSNK1D/LATS1/TGFBR1/ID1/CTNNB1/PPP1CA/TP53BP2/PPP2R2D/FBXW11/WNT8B/YWHAQ/SAV1/CSNK1E/DLG1/BMP7/DVL2/WNT2B/DLG3/WNT11/WNT1/DLG5/TEAD4/CTNNA1/PRKCZ/BIRC5/MOB1B/CDH1/FZD9/SMAD7/PPP2CA	49
KEGG	hsa04915	Estrogen signaling pathway	43/2550	138/8135	0.5514	0.8606	0.6536	GRB2/HSP90B1/CREB1/CALM1/HSP90AB1/KRAS/GNAI2/RAF1/MAPK3/ITPR1/PRKACA/GNAS/KRT10/CREB3/SHC1/CREB3L4/GABBR1/MMP9/ADCY4/SOS2/PRKACB/HSPA1L/ATF2/ITPR3/CREB3L2/NCOA2/MAP2K2/PIK3CA/HSP90AA1/MAPK1/KRT24/GNAI1/EBAG9/FKBP4/KRT33B/KRT14/AKT1/KRT19/KRT16/HBEGF/HRAS/ADCY8/PIK3R2	43
KEGG	hsa00220	Arginine biosynthesis	7/2550	22/8135	0.5609	0.8673	0.6587	ARG1/ARG2/GOT2/OTC/ASL/NOS1/GLS2	7
KEGG	hsa00900	Terpenoid backbone biosynthesis	7/2550	22/8135	0.5609	0.8673	0.6587	PMVK/PDSS2/PCYOX1/IDI1/HMGCS1/ICMT/FDPS	7
KEGG	hsa04014	Ras signaling pathway	72/2550	232/8135	0.5664	0.8709	0.6615	GNB1/GRB2/CALM1/PRKCB/RALBP1/KRAS/MAPK8/RAF1/MAPK3/HTR7/RELA/GRIN1/ETS1/PRKACA/EFNA4/CHUK/EPHA2/NGF/IKBKB/CDC42/SHC1/ZAP70/STK4/PRKCG/BAD/KSR2/SOS2/PRKACB/GNG11/TIAM1/RASSF5/GNG8/IKBKG/PLD2/TBK1/FLT4/GNB4/MAP2K2/MAPK9/NFKB1/RRAS/PIK3CA/CSF1R/RAP1B/PLA2G2E/MAPK1/RALB/RAC3/PAK2/FOXO4/RRAS2/INSR/FGF10/RAC2/VEGFA/GNG3/ABL1/RASA1/GNGT2/AKT1/PGF/SYNGAP1/FGF3/REL/FGF16/EGF/HRAS/GNB2/MRAS/PIK3R2/ABL2/HGF	72
KEGG	hsa00480	Glutathione metabolism	18/2550	58/8135	0.5699	0.8709	0.6615	GPX4/TXNDC12/GSTP1/IDH2/GSTM5/GGT7/SRM/RRM2B/GCLM/GGCT/RRM1/MGST2/NAT8B/GSTA4/ODC1/GPX2/HPGDS/GSTT2	18
KEGG	hsa00640	Propanoate metabolism	10/2550	32/8135	0.571	0.8709	0.6615	HADHA/ALDH6A1/MCEE/BCKDHA/PCCB/ACOX1/ECHS1/EHHADH/BCKDHB/SUCLG1	10
KEGG	hsa05332	Graft-versus-host disease	13/2550	42/8135	0.5799	0.8804	0.6687	FAS/HLA-A/HLA-C/HLA-DPB1/HLA-DPA1/HLA-G/CD86/HLA-DOA/KIR2DL5A/KIR2DL2/HLA-DOB/KIR3DL3/HLA-E	13
KEGG	hsa04918	Thyroid hormone synthesis	23/2550	75/8135	0.594	0.8957	0.6803	HSP90B1/CREB1/PRKCB/PDIA4/ITPR1/PRKACA/GNAS/DUOXA2/CREB3/TTF2/CREB3L4/PRKCG/ADCY4/PRKACB/ATF2/ITPR3/CREB3L2/TTF1/ATP1B1/ASGR1/FXYD2/GPX2/ADCY8	23
KEGG	hsa04360	Axon guidance	56/2550	182/8135	0.5953	0.8957	0.6803	BMPR2/PLXNC1/KRAS/GNAI2/RAF1/MAPK3/EFNA4/EPHA2/CDC42/RYK/NFATC3/CAMK2D/EPHA4/CFL1/MYL12B/CXCR4/SEMA5A/FYN/CDK5/PLXNB2/PDPK1/RRAS/PIK3CA/LRRC4/PTK2/MAPK1/SRGAP2/EPHB2/BMP7/RAC3/PAK2/GNAI1/SEMA7A/UNC5B/UNC5A/RHOD/RAC2/EPHB1/FES/ABL1/RASA1/SEMA4D/TRPC1/NEO1/NFATC2/DPYSL2/SEMA3G/HRAS/PRKCZ/ITGB1/RGS3/ABLIM1/PIK3R2/EPHA5/PPP3R1/SHH	56
KEGG	hsa00350	Tyrosine metabolism	11/2550	36/8135	0.603	0.9031	0.6859	GSTZ1/MIF/FAHD1/GOT2/AOC2/ALDH3B2/FAH/DDC/ADH5/COMT/AOC3	11
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	7/2550	23/8135	0.615	0.917	0.6965	MDH1/SLC25A10/CA2/ATP1B1/PCK2/FXYD2/GLS2	7
KEGG	hsa04921	Oxytocin signaling pathway	47/2550	154/8135	0.6184	0.918	0.6972	CALM1/PRKCB/PIK3CG/KRAS/PRKAG1/GNAI2/RAF1/CAMK1D/MAPK3/PRKAA1/ITPR1/PPP1CB/CACNA2D3/PRKACA/GNAS/PPP1R12A/RCAN1/OXTR/NFATC3/CAMK2D/CAMK1/PRKCG/PIK3R5/ADCY4/CACNG1/PRKACB/MAPK7/ITPR3/PPP1CA/MAP2K2/EEF2/NFATC1/RYR2/MAPK1/PTGS2/GNAI1/CACNB2/MYL6/CDKN1A/CACNG7/NFATC2/HRAS/ADCY8/OXT/CACNB4/MYL6B/PPP3R1	47
KEGG	hsa05217	Basal cell carcinoma	19/2550	63/8135	0.6274	0.9272	0.7042	BAX/DVL3/FZD6/FZD2/DDB2/FZD1/PTCH2/GADD45A/CTNNB1/BAK1/WNT8B/POLK/DVL2/WNT2B/WNT11/CDKN1A/WNT1/FZD9/SHH	19
KEGG	hsa05230	Central carbon metabolism in cancer	21/2550	70/8135	0.6402	0.9337	0.7092	KRAS/RAF1/MAPK3/IDH2/HK1/HIF1A/SIRT3/MAP2K2/PIK3CA/PDHB/PKM/MAPK1/PGAM1/MTOR/AKT1/HK3/HKDC1/SLC7A5/HRAS/GLS2/PIK3R2	21
KEGG	hsa04145	Phagosome	46/2550	152/8135	0.6441	0.9337	0.7092	CORO1A/M6PR/ATP6V1G1/TAP2/OLR1/LAMP1/HLA-A/ATP6V1D/THBS1/CALR/SEC61A2/THBS3/ATP6V1E2/TCIRG1/THBS4/HLA-C/HLA-DPB1/HLA-DPA1/COMP/HLA-G/C1R/EEA1/HLA-DOA/FCGR3B/ATP6V0A2/RILP/ITGA5/NOS1/ATP6V0B/PIK3C3/TUBA1B/TLR6/TUBB1/SCARB1/ATP6V0D2/ITGB5/ITGAV/HLA-DOB/MBL2/DYNC1I2/ATP6V1H/ATP6V1E1/ITGB1/TUBA4A/HLA-E/MSR1	46
KEGG	hsa00514	Other types of O-glycan biosynthesis	14/2550	47/8135	0.6448	0.9337	0.7092	POMT1/OGT/XXYLT1/GALNT6/POFUT1/GALNT10/GALNT3/EOGT/PLOD3/GXYLT1/GALNT9/GALNT1/ST6GAL1/GALNT11	14
KEGG	hsa00062	Fatty acid elongation	8/2550	27/8135	0.6469	0.9337	0.7092	HADHA/HADH/ECHS1/ELOVL7/ELOVL6/TECR/MECR/HSD17B12	8
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	8/2550	27/8135	0.6469	0.9337	0.7092	ACOX1/ELOVL7/ACAA1/ELOVL6/TECR/FADS2/HSD17B12/SCD	8
KEGG	hsa00010	Glycolysis / Gluconeogenesis	20/2550	67/8135	0.6491	0.9337	0.7092	PGK1/HK1/AKR1A1/ENO2/TPI1/BPGM/ALDH3B2/ALDH9A1/PDHB/PKM/ALDH3A2/PGAM1/PGM2/GAPDH/ADH5/PCK2/HK3/HKDC1/FBP1/ALDOA	20
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/2550	100/8135	0.6513	0.9337	0.7092	IL6R/TNFRSF10A/IL6ST/CCR10/CXCL2/CXCR5/CXCL5/CXCR4/TNFRSF1B/IL2RB/CXCR1/IL10/CSF1R/PPBP/XCR1/CCR8/CCR2/ACKR4/PF4/TNFRSF10C/IL20RB/ACKR3/IL20/CXCR2/PF4V1/CCR5/CCL27/IL18R1/IL18RAP/IL34	30
KEGG	hsa04713	Circadian entrainment	29/2550	97/8135	0.6584	0.9398	0.7138	GNB1/CREB1/CALM1/PRKCB/GNAI2/MAPK3/ITPR1/GRIN1/PRKACA/GNAS/CAMK2D/PRKCG/ADCY4/PRKACB/RASD1/GNG11/GNG8/ITPR3/MTNR1B/GNB4/MTNR1A/RYR2/MAPK1/NOS1/GNAI1/GNG3/GNGT2/GNB2/ADCY8	29
KEGG	hsa04977	Vitamin digestion and absorption	7/2550	24/8135	0.6653	0.9455	0.7182	ABCC1/SLC5A6/SLC19A2/BTD/SLC52A3/SCARB1/MMACHC	7
KEGG	hsa05032	Morphine addiction	27/2550	91/8135	0.6732	0.951	0.7223	GNB1/PDE8A/PRKCB/ARRB1/GNAI2/PDE4B/PRKACA/GNAS/GABRR2/CACNA1B/PRKCG/GABBR1/ADCY4/PRKACB/GNG11/GNG8/SLC32A1/GNB4/GRK4/GNAI1/GNG3/GNGT2/PDE1A/PDE3B/GNB2/ADCY8/PDE4A	27
KEGG	hsa00240	Pyrimidine metabolism	17/2550	58/8135	0.6784	0.951	0.7223	TK2/NME3/NME6/NME1/DCTPP1/HDDC2/AK9/RRM2B/NUDT2/RRM1/DHODH/CTPS1/TYMS/NT5C3A/TK1/DTYMK/UCKL1	17
KEGG	hsa04022	cGMP-PKG signaling pathway	50/2550	167/8135	0.6815	0.951	0.7223	SLC25A6/CREB1/CALM1/PIK3CG/GNAI2/RAF1/VDAC2/MAPK3/SLC25A5/ITPR1/PPP1CB/PPP1R12A/CREB3/KCNMB3/NFATC3/ADRA2B/CREB3L4/PIK3R5/BAD/ADCY4/MRVI1/ATF2/ITPR3/CREB3L2/PPP1CA/OPRD1/GNA11/MYH7/MAP2K2/NFATC1/MAPK1/NPPC/GNAI1/INSR/ATP1B1/VDAC3/VASP/ATP2A2/GNA13/SRF/AKT1/FXYD2/NFATC2/MEF2D/AGTR1/PDE3B/ADCY8/NPPB/ADRB1/PPP3R1	50
KEGG	hsa05330	Allograft rejection	11/2550	38/8135	0.6834	0.951	0.7223	FAS/HLA-A/HLA-C/HLA-DPB1/HLA-DPA1/HLA-G/CD86/IL10/HLA-DOA/HLA-DOB/HLA-E	11
KEGG	hsa05340	Primary immunodeficiency	11/2550	38/8135	0.6834	0.951	0.7223	TAP2/RFXANK/BTK/ZAP70/PTPRC/IKBKG/UNG/CD3D/ICOS/TNFRSF13C/JAK3	11
KEGG	hsa00600	Sphingolipid metabolism	15/2550	52/8135	0.7005	0.9708	0.7374	UGCG/CERS2/HEXA/SGMS1/NEU2/SMPD3/SPHK2/SPTLC2/CERS4/SGPL1/SPTLC1/SGPP2/SPHK1/HEXB/GBA2	15
KEGG	hsa04330	Notch signaling pathway	17/2550	59/8135	0.7085	0.9779	0.7427	RBPJ/DVL3/CTBP1/CREBBP/PSENEN/APH1A/MAML1/KAT2B/DLL1/NUMB/HES5/CIR1/DVL2/ATXN1L/HDAC1/DTX3L/HDAC2	17
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/2550	53/8135	0.731	1	0.7595	PRKCB/PRKACA/GNAS/PRKCG/PRKACB/AP2B1/AP2S1/ATP1B1/CLTA/FXYD2/CLTC/AP2A2/CLTB/DNM3/DNM2	15
KEGG	hsa04392	Hippo signaling pathway - multiple species	8/2550	29/8135	0.7328	1	0.7595	RASSF4/LIMD1/MOB1A/LATS1/SAV1/CSNK1E/TEAD4/MOB1B	8
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	10/2550	36/8135	0.7351	1	0.7595	NADK2/SIRT1/NMNAT1/SIRT3/QPRT/NNMT/NMNAT3/NAPRT/BST1/NMRK2	10
KEGG	hsa05134	Legionellosis	16/2550	57/8135	0.748	1	0.7595	CLK1/VCP/RELA/PYCARD/CXCL2/HSPA1L/TLR5/NAIP/NFKB1/NFKB2/BCL2L13/CASP8/HBS1L/BNIP3/SAR1A/HSPD1	16
KEGG	hsa00564	Glycerophospholipid metabolism	28/2550	98/8135	0.7575	1	0.7595	DGKH/PCYT1A/GPCPD1/DGKD/PEMT/TAZ/LYPLA1/MBOAT1/DGKA/PTDSS1/AGPAT3/ETNK1/LPCAT4/ACHE/PLD4/LPCAT3/PLD2/LPIN3/PGS1/CHKB/DGKQ/PLA2G2E/AGPAT4/CHPT1/ADPRM/PCYT1B/PNPLA7/AGPAT1	28
KEGG	hsa04925	Aldosterone synthesis and secretion	28/2550	98/8135	0.7575	1	0.7595	CREB1/CALM1/PRKCB/NR4A2/CAMK1D/ITPR1/PRKACA/GNAS/ATF1/CREB3/CAMK2D/CAMK1/CREB3L4/PRKCG/ADCY4/PRKACB/STAR/ATF2/ITPR3/CREB3L2/GNA11/ATP1B1/DAGLB/SCARB1/LIPE/AGTR1/ADCY8/PRKD3	28
KEGG	hsa00531	Glycosaminoglycan degradation	5/2550	19/8135	0.7591	1	0.7595	HEXA/IDS/HEXB/HYAL2/GALNS	5
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	5/2550	19/8135	0.7591	1	0.7595	CS/IDH2/GOT2/IDH3G/ACO1	5
KEGG	hsa04962	Vasopressin-regulated water reabsorption	12/2550	44/8135	0.7695	1	0.7595	CREB1/PRKACA/GNAS/CREB3/CREB3L4/PRKACB/DCTN6/DCTN5/CREB3L2/DYNLL1/DYNLL2/DYNC1I2	12
KEGG	hsa04514	Cell adhesion molecules	43/2550	149/8135	0.7718	1	0.7595	HLA-A/ITGAL/GLG1/PDCD1/ICAM3/HLA-C/HLA-DPB1/IGSF11/PTPRC/CD274/NLGN2/CDH4/HLA-DPA1/HLA-G/SELP/CLDN2/CD86/HLA-DOA/LRRC4/SPN/ICOS/CDH5/NRXN3/MPZL1/VCAM1/CLDN5/ALCAM/ITGA9/F11R/MAG/CDH3/CD99L2/ITGAV/HLA-DOB/NEO1/NEGR1/ITGB1/CLDN6/CDH1/HLA-E/VTCN1/NLGN4X/OCLN	43
KEGG	hsa04530	Tight junction	49/2550	169/8135	0.772	1	0.7595	PPP2R1A/ACTR2/ARPC1B/TJAP1/PRKCI/PRKAG1/MAPK8/CD1E/EZR/CD1C/PRKAA1/CD1A/SCRIB/PRKACA/ARPC3/PPP2R2A/CDC42/MYL12B/PRKACB/TIAM1/CTTN/PPP2R2D/CDK4/CLDN2/MSN/CD1B/MAPK9/SYMPK/DLG1/ARPC4/TUBA1B/DLG3/VASP/MYL6/CLDN5/MYH9/PCNA/F11R/TJP2/PRKCZ/ITGB1/CLDN6/RDX/TUBA4A/RAB8B/MYL6B/PPP2CA/OCLN/MAP2K7	49
KEGG	hsa04927	Cortisol synthesis and secretion	18/2550	65/8135	0.7778	1	0.7595	CREB1/PDE8A/ITPR1/PRKACA/GNAS/CREB3/CREB3L4/ADCY4/PRKACB/STAR/ATF2/ITPR3/CREB3L2/GNA11/PBX1/SCARB1/AGTR1/ADCY8	18
KEGG	hsa04727	GABAergic synapse	25/2550	89/8135	0.7808	1	0.7595	GNB1/PRKCB/GNAI2/SLC38A2/PRKACA/GABRR2/GABARAPL2/CACNA1B/PRKCG/GABBR1/ADCY4/PRKACB/SLC38A1/GNG11/GNG8/SLC32A1/GNB4/GNAI1/GNG3/GNGT2/GABARAP/TRAK2/GNB2/ADCY8/GLS2	25
KEGG	hsa04911	Insulin secretion	24/2550	86/8135	0.789	1	0.7595	CREB1/PRKCB/PRKACA/GNAS/CREB3/KCNMB3/CAMK2D/CREB3L4/PRKCG/ADCY4/TRPM4/PRKACB/ATF2/ITPR3/CREB3L2/GNA11/RYR2/CCKAR/RAB3A/ATP1B1/FFAR1/KCNN1/FXYD2/ADCY8	24
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2550	27/8135	0.7899	1	0.7595	FUT7/ST3GAL4/B4GALT4/B3GNT2/FUT4/B3GNT4/GCNT2	7
KEGG	hsa05133	Pertussis	21/2550	76/8135	0.794	1	0.7595	CALM1/GNAI2/MAPK11/MAPK8/MAPK3/RELA/PYCARD/C4BPB/CFL1/CXCL5/C1R/IL10/MAPK9/NFKB1/C1QA/MAPK1/NOD1/ITGA5/GNAI1/MAPK13/ITGB1	21
KEGG	hsa00052	Galactose metabolism	8/2550	31/8135	0.8032	1	0.7595	UGP2/GALT/HK1/GALK1/AKR1B1/PGM2/HK3/HKDC1	8
KEGG	hsa05310	Asthma	8/2550	31/8135	0.8032	1	0.7595	FCER1A/HLA-DPB1/HLA-DPA1/IL10/HLA-DOA/IL9/HLA-DOB/IL13	8
KEGG	hsa04923	Regulation of lipolysis in adipocytes	15/2550	56/8135	0.8102	1	0.7595	GNAI2/PRKACA/GNAS/ADCY4/PRKACB/PIK3CA/PTGS2/GNAI1/INSR/AKT1/LIPE/PDE3B/ADCY8/ADRB1/PIK3R2	15
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	27/2550	98/8135	0.8218	1	0.7595	CALM1/PRKCB/MAP2K6/MAPK11/MAPK8/ITPR1/PPP1CB/PRKACA/GNAS/HTR2B/NGF/CAMK2D/PRKCG/ADCY4/PTGER4/PRKACB/ITPR3/PPP1CA/P2RY2/TRPV2/MAPK9/PIK3CA/TRPM8/ALOX12/MAPK13/ADCY8/PIK3R2	27
KEGG	hsa00650	Butanoate metabolism	7/2550	28/8135	0.8226	1	0.7595	HADHA/HADH/ECHS1/HMGCS1/EHHADH/AACS/HMGCL	7
KEGG	hsa00120	Primary bile acid biosynthesis	4/2550	17/8135	0.83	1	0.7595	SLC27A5/AMACR/CH25H/ACOT8	4
KEGG	hsa00910	Nitrogen metabolism	4/2550	17/8135	0.83	1	0.7595	CA2/CA14/CA1/CA8	4
KEGG	hsa00860	Porphyrin metabolism	11/2550	43/8135	0.8368	1	0.7595	COX15/HMOX2/FXN/HMBS/ALAD/UROD/BLVRB/CPOX/BLVRA/COX10/MMAB	11
KEGG	hsa04940	Type I diabetes mellitus	11/2550	43/8135	0.8368	1	0.7595	FAS/HLA-A/HLA-C/HLA-DPB1/HLA-DPA1/HLA-G/CD86/HLA-DOA/HLA-DOB/HSPD1/HLA-E	11
KEGG	hsa00620	Pyruvate metabolism	12/2550	47/8135	0.8463	1	0.7595	FH/MDH2/MDH1/HAGH/AKR1A1/PC/ALDH9A1/PDHB/PKM/ALDH3A2/ADH5/PCK2	12
KEGG	hsa05321	Inflammatory bowel disease	17/2550	65/8135	0.8513	1	0.7595	STAT4/IL4R/RELA/HLA-DPB1/TLR5/HLA-DPA1/IL10/HLA-DOA/NFKB1/NFATC1/IL21R/HLA-DOB/IL13/IL18R1/IL18RAP/IL17F/MAF	17
KEGG	hsa04924	Renin secretion	18/2550	69/8135	0.8598	1	0.7595	CREB1/CALM1/GNAI2/ITPR1/PRKACA/GNAS/PTGER4/PRKACB/ITPR3/GNAI1/CTSB/PDE1A/CLCA2/CLCA1/AGTR1/PDE3B/ADRB1/PPP3R1	18
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	9/2550	37/8135	0.8657	1	0.7595	ADSL/RIMKLB/GOT2/NIT2/ASL/ASRGL1/ASNS/AGXT/GLS2	9
KEGG	hsa05143	African trypanosomiasis	9/2550	37/8135	0.8657	1	0.7595	THOP1/PRKCB/FAS/PRKCG/IL10/HBB/APOL1/VCAM1/TLR9	9
KEGG	hsa00340	Histidine metabolism	5/2550	22/8135	0.8668	1	0.7595	CARNS1/ALDH3B2/ALDH9A1/ALDH3A2/CNDP2	5
KEGG	hsa02010	ABC transporters	11/2550	45/8135	0.8791	1	0.7595	ABCB10/TAP2/ABCB7/ABCC1/ABCC2/ABCG1/ABCA5/ABCC3/ABCB9/ABCA1/ABCB1	11
KEGG	hsa04512	ECM-receptor interaction	23/2550	88/8135	0.8812	1	0.7595	THBS1/THBS3/THBS4/COL1A1/DAG1/COL2A1/COMP/RELN/TNN/ITGA11/ITGA5/ITGA3/ITGA9/ITGB5/CD47/COL9A2/ITGAV/ITGA2B/CHAD/COL1A2/ITGB1/HSPG2/COL4A2	23
KEGG	hsa04972	Pancreatic secretion	27/2550	102/8135	0.8813	1	0.7595	PRKCB/CTRL/ITPR1/GNAS/RAB3D/CELA3A/CELA3B/PRKCG/SLC12A2/ADCY4/ITPR3/PRSS2/PRSS3/CA2/RAP1B/PLA2G2E/RYR2/CCKAR/ATP1B1/ATP2A2/CEL/FXYD2/TRPC1/CLCA2/CLCA1/BST1/ADCY8	27
KEGG	hsa05414	Dilated cardiomyopathy	25/2550	96/8135	0.8936	1	0.7595	CACNA2D3/PRKACA/GNAS/ADCY4/CACNG1/PRKACB/DAG1/TPM3/MYH7/ITGA11/RYR2/ITGA5/CACNB2/ATP2A2/ITGA3/ITGA9/ITGB5/TNNC1/ITGAV/ITGA2B/CACNG7/ITGB1/ADCY8/CACNB4/ADRB1	25
KEGG	hsa05202	Transcriptional misregulation in cancer	53/2550	193/8135	0.8965	1	0.7595	CDK9/BAX/SS18L1/FUT8/RELA/MEIS1/SS18/DDB2/KMT2A/ATF1/BIRC2/CCND2/NCOR1/CDKN2C/TRAF1/TGFBR2/BIRC3/MDM2/ELK4/MMP9/ASPSCR1/DOT1L/JMJD1C/PRCC/GADD45A/IL2RB/BAK1/CD86/EYA1/CCNT2/ETV6/NFKB1/POLK/NR4A3/CSF1R/CCNT1/PTK2/PBX1/CCNA2/RXRA/ZBTB17/ETV1/CEBPA/CDKN1A/HDAC1/SPINT1/MLF1/REL/PBX3/HDAC2/MAF/NUPR1/SIN3A	53
KEGG	hsa04217	Necroptosis	43/2550	159/8135	0.8987	1	0.7595	SLC25A6/XIAP/BAX/TNFRSF10A/HSP90AB1/IRF9/TYK2/MAPK8/VDAC2/CFLAR/SLC25A5/FAS/STAT4/VPS4B/CHMP2A/RIPK1/PARP1/BIRC2/USP21/PYCARD/BIRC3/FADD/CAMK2D/JAK2/AIFM1/IFNAR1/TRAF5/MAPK9/HSP90AA1/STAT5A/IFNA17/PPIA/PYGM/CASP8/TRADD/VDAC3/CHMP4B/STAT5B/TNFAIP3/JAK3/ALOX15/CAPN1/SHARPIN	43
KEGG	hsa04724	Glutamatergic synapse	30/2550	114/8135	0.8991	1	0.7595	GNB1/PRKCB/GNAI2/SLC38A2/MAPK3/ITPR1/GRIN1/GRIN3B/PRKACA/GNAS/PRKCG/ADCY4/HOMER3/PRKACB/SLC38A1/GNG11/GNG8/PLD2/ITPR3/GNB4/MAPK1/GNAI1/GNG3/GNGT2/TRPC1/GNB2/ADCY8/GLS2/GRM6/PPP3R1	30
KEGG	hsa05144	Malaria	12/2550	50/8135	0.9016	1	0.7595	THBS1/ITGAL/THBS3/THBS4/GYPC/COMP/SELP/IL10/HBB/VCAM1/TLR9/HGF	12
KEGG	hsa00561	Glycerolipid metabolism	15/2550	61/8135	0.9021	1	0.7595	DGKH/DGKD/MBOAT1/DGKA/AKR1A1/AGPAT3/LPIN3/ALDH9A1/DGKQ/ALDH3A2/AKR1B1/AGPAT4/CEL/AGPAT1/PNPLA3	15
KEGG	hsa05152	Tuberculosis	49/2550	180/8135	0.9022	1	0.7595	CORO1A/BAX/CREB1/CALM1/MAPK11/MAPK8/RAF1/MAPK3/LAMP1/RELA/CREBBP/RFXANK/TCIRG1/FADD/CAMK2D/HSPA9/HLA-DPB1/BAD/JAK2/HLA-DPA1/SYK/SPHK2/IL10/EEA1/MAPK9/HLA-DOA/NFKB1/PLK3/FCGR3B/ATP6V0A2/MAPK1/IFNA17/ATP6V0B/CASP8/PIK3C3/TRADD/TLR6/LSP1/ATP6V0D2/MAPK13/NFYA/AKT1/TLR9/HLA-DOB/CAMP/ATP6V1H/SPHK1/HSPD1/PPP3R1	49
KEGG	hsa04971	Gastric acid secretion	19/2550	76/8135	0.9092	1	0.7595	CALM1/PRKCB/GNAI2/EZR/ITPR1/PRKACA/GNAS/CAMK2D/PRKCG/ADCY4/PRKACB/ITPR3/CA2/GNAI1/ATP1B1/KCNJ16/SST/ADCY8/KCNJ15	19
KEGG	hsa00500	Starch and sucrose metabolism	8/2550	36/8135	0.9174	1	0.7595	UGP2/GYS2/HK1/PYGM/PGM2/HK3/HKDC1/AGL	8
KEGG	hsa00512	Mucin type O-glycan biosynthesis	8/2550	36/8135	0.9174	1	0.7595	GALNT6/ST3GAL1/GALNT10/GALNT3/ST3GAL2/GALNT9/GALNT1/GALNT11	8
KEGG	hsa05146	Amoebiasis	26/2550	102/8135	0.9199	1	0.7595	PRKCB/SERPINB6/CD1E/CD1C/CD1A/RELA/PRKACA/GNAS/C9/COL1A1/CXCL2/PRDX1/SERPINB9/PRKCG/ARG1/ARG2/PRKACB/GNA11/CD1B/IL10/NFKB1/PIK3CA/PTK2/COL1A2/COL4A2/PIK3R2	26
KEGG	hsa05140	Leishmaniasis	19/2550	77/8135	0.9205	1	0.7595	PRKCB/MAPK11/TAB1/MAPK3/RELA/HLA-DPB1/MAP3K7/JAK2/HLA-DPA1/IL10/HLA-DOA/NFKB1/FCGR3B/MAPK1/PTGS2/TAB2/MAPK13/HLA-DOB/ITGB1	19
KEGG	hsa04610	Complement and coagulation cascades	21/2550	85/8135	0.9282	1	0.7595	CD46/C9/C4BPB/CD55/C1R/FGB/CLU/F3/C6/C1QA/CFD/FGG/F10/SERPINB2/CD59/F2/F2R/MBL2/CFB/PROC/CFH	21
KEGG	hsa00770	Pantothenate and CoA biosynthesis	4/2550	21/8135	0.933	1	0.7595	COASY/AASDHPPT/ALDH3A2/PANK3	4
KEGG	hsa04978	Mineral absorption	14/2550	60/8135	0.9342	1	0.7595	HMOX2/SLC31A1/SLC39A4/ATP7A/SLC26A6/ATP1B1/STEAP1/TRPV6/CYBRD1/FXYD2/SLC26A9/SLC30A1/ATOX1/STEAP2	14
KEGG	hsa05323	Rheumatoid arthritis	23/2550	93/8135	0.9352	1	0.7595	ATP6V1G1/CTSK/ACP5/ATP6V1D/ITGAL/ATP6V1E2/TCIRG1/CXCL2/HLA-DPB1/CXCL5/HLA-DPA1/LTB/CD86/HLA-DOA/ATP6V0A2/ATP6V0B/VEGFA/ATP6V0D2/HLA-DOB/IL11/ATP6V1H/ATP6V1E1/IL15	23
KEGG	hsa04672	Intestinal immune network for IgA production	11/2550	49/8135	0.9372	1	0.7595	CCR10/HLA-DPB1/CXCR4/HLA-DPA1/CD86/IL10/HLA-DOA/ICOS/TNFRSF13C/HLA-DOB/IL15	11
KEGG	hsa05320	Autoimmune thyroid disease	12/2550	53/8135	0.9393	1	0.7595	FAS/HLA-A/HLA-C/HLA-DPB1/HLA-DPA1/HLA-G/CD86/IL10/HLA-DOA/IFNA17/HLA-DOB/HLA-E	12
KEGG	hsa00053	Ascorbate and aldarate metabolism	6/2550	30/8135	0.9435	1	0.7595	AKR1A1/MIOX/UGDH/RGN/ALDH9A1/ALDH3A2	6
KEGG	hsa04979	Cholesterol metabolism	11/2550	50/8135	0.9472	1	0.7595	VDAC2/SOAT1/STAR/LIPA/TSPO/SORT1/VDAC3/SCARB1/ABCA1/VAPA/APOC2	11
KEGG	hsa00983	Drug metabolism - other enzymes	19/2550	80/8135	0.9474	1	0.7595	ITPA/TK2/NME3/TPMT/NME6/NME1/GSTP1/GSTM5/RRM2B/IMPDH2/RRM1/HPRT1/MGST2/GSTA4/IMPDH1/TK1/GSTT2/CYP2A6/UCKL1	19
KEGG	hsa04640	Hematopoietic cell lineage	24/2550	99/8135	0.9524	1	0.7595	IL6R/CD1E/CD1C/CD1A/IL4R/IL11RA/HLA-DPB1/IL7/DNTT/HLA-DPA1/CD55/CD1B/CD3G/HLA-DOA/CSF1R/ITGA5/CD3D/ITGA3/CD59/HLA-DOB/ITGA2B/CD24/IL11/CD33	24
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/2550	77/8135	0.9525	1	0.7595	CACNA2D3/CACNG1/DAG1/CTNNB1/ITGA11/RYR2/ITGA5/CACNB2/ATP2A2/ITGA3/ITGA9/ITGB5/ITGAV/ITGA2B/CACNG7/CTNNA1/ITGB1/CACNB4	18
KEGG	hsa04913	Ovarian steroidogenesis	11/2550	51/8135	0.9558	1	0.7595	PRKACA/GNAS/ADCY4/PRKACB/STAR/PTGS2/INSR/HSD17B1/SCARB1/CYP1B1/ADCY8	11
KEGG	hsa05150	Staphylococcus aureus infection	23/2550	96/8135	0.9564	1	0.7595	ITGAL/KRT10/HLA-DPB1/HLA-DPA1/C1R/SELP/IL10/HLA-DOA/C1QA/CFD/FCGR3B/KRT24/FGG/KRT33B/KRT14/KRT19/KRT16/HLA-DOB/MBL2/CAMP/CFB/CFH/FPR1	23
KEGG	hsa04614	Renin-angiotensin system	4/2550	23/8135	0.9594	1	0.7595	THOP1/PREP/ATP6AP2/AGTR1	4
KEGG	hsa04970	Salivary secretion	22/2550	93/8135	0.9602	1	0.7595	CALM1/PRKCB/ITPR1/PRKACA/GNAS/PRKCG/SLC12A2/ADCY4/PRKACB/ITPR3/BEST2/CST1/NOS1/CST4/ATP1B1/CST5/TRPV6/FXYD2/BST1/CAMP/ADCY8/ADRB1	22
KEGG	hsa05410	Hypertrophic cardiomyopathy	21/2550	90/8135	0.9639	1	0.7595	PRKAG1/PRKAA1/CACNA2D3/CACNG1/DAG1/TPM3/MYH7/ITGA11/RYR2/ITGA5/CACNB2/ATP2A2/ITGA3/ITGA9/ITGB5/TNNC1/ITGAV/ITGA2B/CACNG7/ITGB1/CACNB4	21
KEGG	hsa00565	Ether lipid metabolism	10/2550	49/8135	0.9691	1	0.7595	PAFAH1B1/PAFAH1B3/LPCAT4/PLD4/PLD2/GDPD1/PAFAH2/PLA2G2E/CHPT1/TMEM86B	10
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/2550	25/8135	0.9759	1	0.7595	ACOX1/ACAA1/PLA2G2E/FADS2	4
KEGG	hsa00040	Pentose and glucuronate interconversions	6/2550	34/8135	0.9772	1	0.7595	CRYL1/SORD/UGP2/AKR1A1/UGDH/AKR1B1	6
KEGG	hsa04270	Vascular smooth muscle contraction	32/2550	134/8135	0.9779	1	0.7595	CALM1/PRKCB/ARAF/RAF1/MAPK3/ITPR1/PPP1CB/BRAF/PRKACA/GNAS/PPP1R12A/KCNMB3/PRKCG/ADCY4/MRVI1/PRKACB/ITPR3/PPP1CA/GNA11/MAP2K2/ARHGEF1/PLA2G2E/MAPK1/NPPC/MYL6/MYH9/GNA13/ARHGEF11/AGTR1/ADCY8/NPPB/MYL6B	32
KEGG	hsa04973	Carbohydrate digestion and absorption	9/2550	47/8135	0.9794	1	0.7595	PRKCB/HK1/PIK3CA/ATP1B1/AKT1/HK3/FXYD2/HKDC1/PIK3R2	9
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/2550	16/8135	0.9799	1	0.7595	GGT7/ADO	2
KEGG	hsa04975	Fat digestion and absorption	8/2550	43/8135	0.9799	1	0.7595	GOT2/SLC27A1/PLA2G2E/SCARB1/CEL/FABP1/ABCA1/AGPAT1	8
KEGG	hsa00590	Arachidonic acid metabolism	12/2550	61/8135	0.9857	1	0.7595	CBR1/LTC4S/PLA2G2E/CYP2U1/PTGS2/ALOX12/PTGDS/CYP2C8/ALOX15/GPX2/HPGDS/PTGES2	12
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/2550	23/8135	0.9888	1	0.7595	POMT1/B3GALNT2/FUT4	3
KEGG	hsa04060	Cytokine-cytokine receptor interaction	75/2550	295/8135	0.9902	1	0.7595	IL6R/BMPR2/TNFRSF10A/IL6ST/IL27RA/LIF/FAS/IL4R/CCR10/IL11RA/TNFSF4/NGF/CXCL2/TGFBR2/CXCR5/CXCL5/IL7/CXCR4/TNFRSF1B/ACVR2A/TGFBR1/IL17RC/LTB/IFNAR1/IL2RB/INHBB/GH1/CXCR1/INHBA/IL1F10/ACVR2B/CD27/IL10/LEPR/CSF1R/IL17RA/PPBP/XCR1/IFNA17/BMP7/CCR8/IL26/TNFSF8/TNFRSF4/CCR2/ACKR4/PF4/IL9/OSM/TNFRSF10C/IL21R/TNFRSF13C/IL20RB/ACKR3/IL13RA2/EDAR/IL11/IL20/IL13/EDA/CXCR2/PF4V1/CSH1/CCR5/CCL27/IL13RA1/IL16/RELT/GDF15/IL18R1/IL15/IL18RAP/IL17D/IL17F/IL34	75
KEGG	hsa04744	Phototransduction	4/2550	29/8135	0.9919	1	0.7595	GNB1/CALM1/RGS9/GUCA1B	4
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	13/2550	69/8135	0.9934	1	0.7595	GSTP1/CBR1/GSTM5/PTGS2/MGST2/CYP1B1/CYP2C8/GSTA4/SULT1A1/HPGDS/GSTT2/CYP2A6/SULT1A2	13
KEGG	hsa05033	Nicotine addiction	6/2550	40/8135	0.9948	1	0.7595	GRIN1/GRIN3B/GABRR2/CACNA1B/SLC32A1/CHRNA6	6
KEGG	hsa05034	Alcoholism	43/2550	187/8135	0.9958	1	0.7595	GNB1/GRB2/CREB1/CALM1/ARAF/KRAS/GNAI2/RAF1/FOSB/MAPK3/PPP1CB/BRAF/HDAC4/GRIN1/GRIN3B/PRKACA/GNAS/CREB3/SHC1/HDAC3/HDAC8/CREB3L4/SOS2/PRKACB/ATF2/GNG11/GNG8/HAT1/CREB3L2/PPP1CA/GNB4/MAPK1/GNAI1/DDC/SLC6A3/GNG3/GNGT2/SLC29A2/HDAC1/SLC29A3/HRAS/GNB2/HDAC2	43
KEGG	hsa04020	Calcium signaling pathway	56/2550	240/8135	0.9978	1	0.7595	SLC25A6/CALM1/PRKCB/MCOLN2/MCU/VDAC2/CAMK1D/HTR7/PLCD1/SLC25A5/MCOLN3/ITPR1/GRIN1/PRKACA/GNAS/HTR2B/NGF/TACR1/CACNA1B/OXTR/CAMK2D/CAMK1/PRKCG/ADCY4/PRKACB/CXCR4/PTK2B/PHKG1/ITPR3/FLT4/SPHK2/HTR4/GNA11/LTB4R2/RYR2/P2RX3/CCKAR/NOS1/FGF10/VDAC3/ATP2A2/VEGFA/PDE1A/ORAI3/TNNC1/F2R/FGF3/PTGER1/FGF16/EGF/AGTR1/ADCY8/SPHK1/ADRB1/PPP3R1/HGF	56
KEGG	hsa00591	Linoleic acid metabolism	3/2550	29/8135	0.9982	1	0.7595	PLA2G2E/CYP2C8/ALOX15	3
KEGG	hsa04976	Bile secretion	16/2550	89/8135	0.9986	1	0.7595	PRKACA/GNAS/SLC27A5/ABCC2/ADCY4/PRKACB/CA2/ABCC3/RXRA/ATP1B1/SCARB1/SLCO1B1/FXYD2/ABCB1/ADCY8/SLC22A1	16
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	13/2550	78/8135	0.999	1	0.7595	GSTP1/AKR7A2/CBR1/GSTM5/AKR7A3/ALDH3B2/MGST2/ADH5/CYP1B1/GSTA4/HPGDS/GSTT2/CYP2A6	13
KEGG	hsa04950	Maturity onset diabetes of the young	2/2550	26/8135	0.9993	1	0.7595	MNX1/HNF1A	2
KEGG	hsa04974	Protein digestion and absorption	18/2550	103/8135	0.9996	1	0.7595	CTRL/SLC38A2/COL1A1/CELA3A/CELA3B/KCNE3/COL2A1/PRSS2/PRSS3/COL26A1/ATP1B1/FXYD2/COL9A2/COL1A2/COL4A2/COL16A1/COL19A1/SLC7A7	18
KEGG	hsa00140	Steroid hormone biosynthesis	8/2550	61/8135	0.9997	1	0.7595	SRD5A3/SULT2B1/HSD17B8/SRD5A2/HSD17B1/COMT/CYP1B1/HSD17B12	8
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	9/2550	66/8135	0.9998	1	0.7595	SEPSECS/GATC/HARS2/FARS2/IARS2/YARS2/FARSB/CARS2/MTFMT	9
KEGG	hsa00982	Drug metabolism - cytochrome P450	10/2550	72/8135	0.9998	1	0.7595	GSTP1/GSTM5/ALDH3B2/MGST2/ADH5/CYP2C8/GSTA4/HPGDS/GSTT2/CYP2A6	10
KEGG	hsa04742	Taste transduction	13/2550	86/8135	0.9998	1	0.7595	PRKACA/GABBR1/ADCY4/PRKACB/TAS2R38/ITPR3/HTR1F/P2RX3/SCNN1G/PDE1A/TAS2R19/ADCY8/HTR1B	13
KEGG	hsa04613	Neutrophil extracellular trap formation	38/2550	190/8135	0.9999	1	0.7595	SLC25A6/PRKCB/MAPK11/GSDMD/RAF1/VDAC2/MAPK3/SLC25A5/RELA/HDAC4/ITGAL/HDAC3/HDAC8/PRKCG/MAP3K7/HAT1/SYK/FGB/SELP/MAP2K2/NFKB1/PIK3CA/CASP4/FCGR3B/CLCN3/MAPK1/MTOR/FGG/RAC2/VDAC3/MAPK13/AKT1/HDAC1/ITGA2B/CAMP/PIK3R2/HDAC2/FPR1	38
KEGG	hsa00830	Retinol metabolism	8/2550	68/8135	1	1	0.7595	RETSAT/PNPLA4/RDH13/ADH5/CYP2C8/RPE65/CYP26B1/CYP2A6	8
KEGG	hsa05206	MicroRNAs in cancer	63/2550	310/8135	1	1	0.7595	GRB2/BMPR2/SOX4/PRKCB/KRAS/SIRT1/RAF1/ABCC1/MAPK3/EZR/STMN1/CREBBP/HDAC4/THBS1/CRK/EFNA4/CCND2/IKBKB/SHC1/VIM/MDM2/EZH2/PRKCG/MMP9/SOS2/MCL1/MAPK7/CDK6/MIRLET7D/SOCS1/PDCD4/BAK1/UBE2I/TNN/DNMT3A/HNRNPK/MAP2K2/NFKB1/PIK3CA/MIR194-2/MAPK1/ITGA5/E2F3/PTGS2/CDKN2A/MTOR/VEGFA/CCNE2/ABL1/CDKN1A/CYP1B1/FOXP1/HDAC1/ABCB1/SLC7A1/HRAS/GLS2/RDX/MIR205/ZEB2/PIK3R2/HDAC2/SPRY2	63
KEGG	hsa04080	Neuroactive ligand-receptor interaction	74/2550	353/8135	1	1	0.7595	HTR7/S1PR4/NPW/LPAR2/GRIN1/GRIN3B/HTR2B/GABRR2/TACR1/OXTR/CHRNB1/ADRA2B/GIPR/GABBR1/UCN2/UTS2R/PTGER4/NPFF/CRHR1/NMB/HTR4/GH1/PRSS2/OPRD1/GALR3/MTNR1B/P2RY2/HTR1F/THRB/LTB4R2/LPAR4/LEPR/PRSS3/TSPO/MTNR1A/P2RX3/CCKAR/GZMA/PMCH/GPR156/CHRNA6/NMU/CHRM4/PENK/PYY/LPAR3/RXFP2/CHRNA3/RXFP3/F2/F2R/GRP/MLN/NPFFR1/PTGER1/SST/AGTR1/SSTR1/KISS1R/CSH1/APLN/VIP/GHSR/OXT/OPRL1/UCN3/ADRB1/GRM6/LPAR6/HTR1B/NPBWR1/PATE1/FPR1/CNR1	74
KEGG	hsa05322	Systemic lupus erythematosus	13/2550	136/8135	1	1	0.7595	SNRPD3/C9/SNRPD1/HLA-DPB1/HLA-DPA1/C1R/CD86/IL10/C6/HLA-DOA/C1QA/FCGR3B/HLA-DOB	13
KEGG	hsa04740	Olfactory transduction	22/2550	440/8135	1	1	0.7595	GNB1/CALM1/ARRB1/PRKACA/CAMK2D/PRKACB/OR3A3/OR6A2/OR7D2/OR52D1/OR2J2/OR4D1/PDE1A/OR7C1/OR3A1/OR1D5/OR10C1/OR1J2/CNGA4/ANO2/OR2J3/OR12D2	22