ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04142	Lysosome	89/3489	132/8135	8.708e-09	2.908e-06	2.099e-06	PSAPL1/AP1M2/CTSZ/CLTB/ATP6V0A4/PSAP/LAPTM5/TPP1/SCARB2/NPC2/LGMN/ACP2/NAGA/CTSO/FUCA1/SLC11A1/HEXB/CD63/PLA2G15/GGA2/GLB1/CTSS/MANBA/GAA/GUSB/PPT1/DMXL2/FUCA2/SUMF1/LAPTM4B/HEXA/NEU1/GNS/CD68/TCIRG1/CTSB/CTSF/AGA/LAMP3/ARSB/NAGLU/GALNS/ARSA/MAN2B1/AP1M1/GNPTG/M6PR/AP4M1/HYAL2/AP4E1/GLA/MCOLN1/GALC/MFSD8/AP1S1/HYAL4/DNASE2/ABCA2/AP1G1/ATP6AP1/AP4B1/IGF2R/CTSD/ACP5/SLC11A2/AP3B2/ATP6V0A2/CTSA/NAGPA/CD164/IDUA/CTSK/AP1G2/HYAL1/SPAM1/NCOA7/CTSH/HGSNAT/PPT2/ATP6V0B/LAMP2/DNASE2B/CLN5/IDS/NAPSA/AP3M1/SGSH/CTSE/AP1B1	89
KEGG	hsa04360	Axon guidance	111/3489	182/8135	5.17e-07	8.633e-05	6.231e-05	PAK6/EPHA1/EFNA1/LIMK2/RGS3/EFNA3/FYN/BMP7/EFNA4/GNAI1/FES/GNAI2/EPHA4/NRP1/EPHB6/RRAS/SRGAP1/SEMA4G/ILK/SEMA6B/NTNG2/WNT4/PRKCZ/GNAI3/HRAS/NEO1/ROBO2/RHOD/ABL1/EFNB2/RAC2/FZD3/RAF1/DPYSL2/ROBO3/EPHB1/PARD3/PPP3CC/CXCR4/RGMA/EPHA2/EPHB3/SEMA3F/CFL2/LRRC4/ABLIM1/LRIG2/GSK3B/RHOA/MYL9/SEMA4A/WNT5B/NFATC4/SSH2/SRGAP3/SSH1/PAK2/WNT5A/CAMK2A/PIK3CD/SEMA4B/EFNB3/TRPC1/PLXNB3/PLXNB1/CXCL12/SLIT1/SEMA5B/SEMA6D/ROCK1/NGEF/NCK1/EPHB2/PARD6B/SEMA3A/SEMA5A/ABLIM3/LRRC4C/NTN4/BMPR1B/PIK3R3/PRKCA/PARD6A/ABLIM2/CFL1/SEMA3C/ROCK2/PLCG1/NFATC3/NTN3/BMPR2/UNC5D/SRGAP2/MYL5/DCC/MYL12B/SEMA4F/BOC/RND1/PLXNB2/SEMA4D/SEMA7A/MAPK1/SSH3/RASA1/TRPC3/PAK1/SEMA3B/NFATC2/PLXNA1/SLIT2	111
KEGG	hsa04144	Endocytosis	144/3489	251/8135	1.964e-06	0.0001907	0.0001376	CHMP4C/FGFR3/ARPC5L/RAB11A/CLTB/RAB11FIP4/AP2A2/PLD1/WIPF1/ARPC1B/TGFBR2/EPN3/FOLR2/IQSEC1/ARRB1/DAB2/ARAP1/ARRB2/FGFR2/CHMP1B/RAB4A/LDLR/SNX2/SMAP1/STAMBP/PRKCZ/SNX4/AP2B1/DNM1/HRAS/CBLB/RAB11FIP5/CHMP4B/ZFYVE9/BIN1/CAPZA3/HSPA6/RAB5C/CBLC/CCR5/RABEP1/AP2M1/RAB31/RAB5A/IL2RG/PDGFRA/IQSEC2/RAB11FIP1/CYTH4/ARAP3/TGFBR1/PIP5K1C/PRKCI/PARD3/EHD2/ARPC1A/ARFGEF2/CHMP2B/CXCR4/WIPF3/NEDD4/HLA-C/SH3GL3/ARPC5/GIT2/FOLR3/DNAJC6/ARAP2/RHOA/SH3KBP1/TSG101/RAB10/HSPA2/AMPH/SNX6/SH3GL2/ACAP1/ARFGEF1/ARFGAP3/VTA1/EHD4/RAB5B/CBL/CHMP7/IQSEC3/ACTR3C/CAPZB/USP8/RAB22A/IGF2R/ITCH/CYTH1/VPS35/HLA-F/PIP5KL1/VPS4B/PARD6B/PSD3/CAV1/EGFR/ASAP3/EPN2/PIP5K1A/SMAD3/EHD3/HLA-B/SNX32/ARPC2/RAB11B/RAB11FIP2/PARD6A/CAPZA2/SMURF2/ARF3/MDM2/CYTH3/WIPF2/ARFGAP1/ARF5/HLA-G/HLA-A/SMAP2/CYTH2/ACAP2/ARF6/IL2RA/STAM/ASAP1/RAB11FIP3/STAM2/VPS36/CXCR1/PSD2/EPS15L1/ARF4/ASAP2/CXCR2/GIT1/CAPZA1/DNM3/EPN1/VPS25/SNF8/ACTR2	144
KEGG	hsa04514	Cell adhesion molecules	92/3489	149/8135	2.283e-06	0.0001907	0.0001376	CDH1/CLDN1/CNTN1/CDH3/IGSF11/HLA-DMA/ICAM2/CLDN8/CD4/SIGLEC1/SDC1/SELPLG/NRXN1/SDC2/ITGAM/OCLN/F11R/GLG1/CD99/CLDN10/NRXN2/CLDN4/HLA-DMB/CD86/ITGB2/ICAM3/SDC3/SELP/CD99L2/ESAM/PECAM1/NTNG2/PTPRC/CDH5/SDC4/PTPRM/CNTNAP1/VCAM1/VCAN/NEO1/JAM2/PTPRF/CADM3/CD8A/CD22/NCAM2/NRCAM/ITGAL/VTCN1/PDCD1LG2/NFASC/ITGA4/HLA-C/LRRC4/CD40/SELL/ITGA9/CD226/HLA-DRB1/NRXN3/HLA-DPA1/CD34/CD2/CLDN16/CD40LG/CLDN19/HLA-F/CLDN5/HLA-DOA/LRRC4C/HLA-DRA/HLA-B/CADM1/CD8B/TIGIT/NLGN2/ITGA6/HLA-G/HLA-A/CD28/NLGN4X/ICAM1/ALCAM/NLGN3/CLDN23/CLDN7/JAM3/ITGB8/ICOS/CD58/CLDN3/SELE	92
KEGG	hsa04670	Leukocyte transendothelial migration	72/3489	114/8135	9.118e-06	0.0005383	0.0003885	CLDN1/NCF4/CLDN8/VAV3/VAV1/GNAI1/ITGAM/GNAI2/OCLN/F11R/CD99/CLDN10/CYBA/CLDN4/RAPGEF4/CYBB/ITGB2/MAPK13/CD99L2/ESAM/PECAM1/EZR/THY1/SIPA1/CDH5/GNAI3/VCAM1/RHOH/JAM2/MAPK12/VASP/CTNND1/RAC2/RAPGEF3/ITGAL/ITGA4/CXCR4/RHOA/NCF2/MYL9/ITK/PXN/RAP1B/ACTN1/PIK3CD/MSN/CXCL12/CLDN16/MAPK11/ROCK1/CLDN19/CLDN5/MMP9/ARHGAP5/MMP2/PIK3R3/PRKCA/ICAM1/VCL/ROCK2/PLCG1/PRKCB/MYL5/MYL2/MAPK14/CLDN23/MYL12B/PTK2B/CLDN7/JAM3/RAP1A/CLDN3	72
KEGG	hsa04015	Rap1 signaling pathway	121/3489	210/8135	9.67e-06	0.0005383	0.0003885	CDH1/FGFR3/LPAR3/CALML5/EFNA1/CSF1R/CALML3/TLN1/EFNA3/CALM3/VAV3/EFNA4/CSF1/VAV1/GNAI1/ITGAM/GNAI2/VEGFC/APBB1IP/PFN4/RASGRP3/RRAS/RAPGEF4/P2RY1/ITGB2/MAPK13/HGF/DOCK4/FGFR2/RAPGEF1/RASGRP2/PDGFD/BRAF/PLCB2/PRKCZ/SIPA1/TIAM1/FGF18/GNAI3/HRAS/LCP2/PDGFB/AKT3/IGF1/MAPK12/MAGI1/VASP/CTNND1/RAC2/KIT/LPAR4/RAF1/ANGPT2/GNAQ/PDGFRA/RAPGEF3/F2R/PRKD1/ARAP3/PRKCI/MAP2K1/ITGAL/PARD3/ADCY4/PDGFRB/ADCY1/FARP2/EPHA2/VEGFB/ITGB3/FLT4/RHOA/PDGFC/FLT1/TEK/FPR1/AKT1/RAP1B/EVL/MAGI2/GNAS/ADORA2B/PFN2/FGF10/ADCY2/RAP1GAP/PIK3CD/LPAR1/EGF/PFN1/MRAS/FGFR1/KDR/SKAP1/MAPK11/PARD6B/TLN2/EGFR/PDGFA/ADCY8/PIK3R3/PRKCA/PARD6A/RGS14/ADCY9/ADCY6/PLCG1/PRKCB/CALM2/PRKD3/MAPK14/RAPGEF5/RALB/FGF17/SIPA1L3/RAP1A/MAPK1/ANGPT1/ITGA2B/FGF6/PGF	121
KEGG	hsa04510	Focal adhesion	116/3489	201/8135	1.328e-05	0.0006339	0.0004575	PAK6/ITGA2/ITGB6/COL4A5/TLN1/FYN/VAV3/LAMB1/PARVB/VAV1/PARVG/VEGFC/ITGA5/SPP1/LAMC2/COL6A1/COL4A1/HGF/LAMB4/COL4A2/ILK/RAPGEF1/GRB2/COL6A2/THBS3/COL4A6/FN1/PDGFD/BRAF/LAMC1/ZYX/THBS4/LAMA4/COL6A3/HRAS/PDGFB/AKT3/IGF1/VASP/RAC2/RAF1/PDGFRA/ITGB5/LAMB2/PIP5K1C/PARVA/MAP2K1/FLNA/PDGFRB/VWF/ITGA4/ITGA10/LAMC3/RELN/VEGFB/ITGB3/FLT4/GSK3B/RHOA/PDGFC/FLT1/MYL9/ITGA9/PXN/LAMB3/AKT1/RAP1B/COL9A3/SHC3/TNC/PAK2/ITGA11/ACTN1/PIK3CD/COMP/EGF/KDR/CAPN2/SHC1/SHC4/PPP1CB/ROCK1/IBSP/MAPK8/TLN2/ARHGAP5/CAV1/EGFR/PIP5K1A/PDGFA/ITGA7/FLNC/CCND2/ITGA3/PIK3R3/PRKCA/LAMA3/LAMA1/ITGA6/FLNB/COL1A2/MYLK4/VCL/ROCK2/ITGB4/PRKCB/MYL5/MYL2/MYL12B/ITGB8/RAP1A/MAPK1/PAK1/ITGA2B/PGF/PTEN	116
KEGG	hsa04640	Hematopoietic cell lineage	63/3489	99/8135	2.316e-05	0.0009669	0.0006978	CD1A/ITGA2/CD24/HLA-DMA/CSF1R/CD33/CD4/EPOR/CSF1/CD37/ITGAM/CD14/ITGA5/HLA-DMB/CD8A/CD22/KIT/CSF3R/MS4A1/CD38/CD3E/CD1D/IL3RA/ITGA4/FCGR1A/ITGB3/IL11/CSF2RA/CD59/HLA-DRB1/IL1R2/FLT3LG/HLA-DPA1/CD34/MME/CD2/CD19/CR1/EPO/CD3D/THPO/IL7R/CD1E/HLA-DOA/IL7/HLA-DRA/CD1B/CD3G/ITGA3/FCER2/CD8B/IL6R/ITGA6/IL5RA/CD1C/CD9/CD5/IL2RA/IL5/DNTT/GP9/ITGA2B/CSF2	63
KEGG	hsa00531	Glycosaminoglycan degradation	17/3489	19/8135	3.344e-05	0.001241	0.0008958	HEXB/GLB1/GUSB/HEXA/GNS/ARSB/NAGLU/GALNS/HPSE/HYAL2/HYAL4/IDUA/HYAL1/SPAM1/HGSNAT/IDS/SGSH	17
KEGG	hsa04611	Platelet activation	75/3489	124/8135	5.338e-05	0.001783	0.001287	ITGA2/TLN1/TBXAS1/FYN/FCER1G/FCGR2A/GNAI1/TBXA2R/PTGS1/GNAI2/APBB1IP/FERMT3/BTK/RASGRP1/P2RY1/PRKACB/MAPK13/PIK3R5/RASGRP2/PLA2G4F/PLCB2/PRKCZ/GNAI3/LCP2/PLA2G4C/AKT3/PIK3CG/MAPK12/VASP/GNAQ/F2R/PIK3R6/PRKCI/ADCY4/ADCY1/VWF/ITGB3/RHOA/AKT1/RAP1B/ITPR3/GNAS/P2RY12/PLA2G4D/ADCY2/SNAP23/PRKACA/PIK3CD/LYN/GP6/SYK/MAPK11/PPP1CB/ROCK1/COL3A1/PRKG1/TLN2/ITPR1/ADCY8/PIK3R3/ITPR2/PTGIR/ADCY9/PRKG2/ADCY6/COL1A2/MYLK4/ROCK2/MAPK14/MYL12B/FGB/RAP1A/MAPK1/GP9/ITGA2B	75
KEGG	hsa04512	ECM-receptor interaction	56/3489	88/8135	6.513e-05	0.001978	0.001427	ITGA2/ITGB6/COL4A5/LAMB1/SDC1/ITGA5/SPP1/LAMC2/COL6A1/COL4A1/LAMB4/COL4A2/HSPG2/COL6A2/THBS3/COL4A6/FN1/LAMC1/THBS4/LAMA4/COL6A3/SDC4/ITGB5/LAMB2/VWF/ITGA4/ITGA10/LAMC3/RELN/SV2A/FREM2/ITGB3/ITGA9/LAMB3/COL9A3/TNC/ITGA11/COMP/GP6/IBSP/HMMR/ITGA7/FRAS1/ITGA3/LAMA3/LAMA1/DMP1/ITGA6/COL1A2/SV2C/ITGB4/SV2B/ITGB8/GP9/ITGA2B/NPNT	56
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	65/3489	106/8135	9.236e-05	0.002571	0.001855	GATA3/GNA12/PLD1/GNAI1/GNAI2/ARRB1/CREB3L2/PRKACB/ARHGEF11/ARRB2/MEF2C/AKAP13/BRAF/PLCB2/TNFSF11/CREB3/GNAI3/CREB5/RAF1/GNAQ/BGLAP/MAP2K1/FOS/ADCY4/ADCY1/RHOA/RXRB/ITPR3/CREB3L1/GNAS/ADCY2/MEF2A/PRKACA/MMP13/PTHLH/MMP14/FGFR1/RUNX2/EGR1/PDE4A/EGFR/ITPR1/ADCY8/NACA/NR4A2/MMP15/PRKCA/ITPR2/ADCY9/KL/CYP24A1/ADCY6/MEF2D/ATF6B/PRKCB/SLC34A3/CREB3L4/VDR/LRP5/CDKN1A/SLC34A2/PTH1R/LRP6/MAPK1/ARAF	65
KEGG	hsa04151	PI3K-Akt signaling pathway	186/3489	354/8135	0.0001176	0.003022	0.002181	FGFR3/LPAR3/ITGA2/EFNA1/MYB/CSF1R/ITGB6/COL4A5/TLR4/EFNA3/EFNA4/PPP2R3A/LAMB1/ERBB3/EREG/PKN1/EPOR/CSF1/PIK3AP1/VEGFC/GNG10/CCNE2/CREB3L2/ITGA5/SPP1/LAMC2/G6PC3/COL6A1/COL4A1/HGF/LAMB4/COL4A2/FGFR2/PIK3R5/PPP2R2C/GRB2/GNG2/COL6A2/CASP9/THBS3/COL4A6/FN1/PDGFD/LAMC1/GNB3/THBS4/LAMA4/NTF4/PHLPP1/MYC/CREB3/FGF18/TGFA/COL6A3/HRAS/IFNAR2/CREB5/PDGFB/AKT3/PIK3CG/YWHAZ/IGF1/MAGI1/IFNAR1/PHLPP2/KIT/LPAR4/IL2RG/RAF1/ANGPT2/PDGFRA/CSF3R/F2R/ITGB5/LAMB2/PIK3R6/HSP90B1/GNG11/MAP2K1/PPP2CA/PDGFRB/CCNE1/VWF/IL3RA/ITGA4/ITGA10/LAMC3/RELN/EPHA2/AREG/VEGFB/ITGB3/FLT4/GSK3B/PDGFC/FLT1/TEK/TLR2/ITGA9/LAMB3/AKT1/GNB4/COL9A3/GNG7/CREB3L1/TNC/MAGI2/FGF10/FASLG/ITGA11/PIK3CD/COMP/LPAR1/EGF/SGK1/FGFR1/KDR/FLT3LG/NFKB1/RPS6/PPP2R2B/MTOR/SYK/CD19/EPO/YWHAE/GNB1/IBSP/IFNA1/IL7R/PKN3/IL7/CDK4/EGFR/GNGT2/EIF4E/EIF4EBP1/PDGFA/BCL2L11/RPS6KB2/ITGA7/CCND2/GNG5/ITGA3/PIK3R3/PRKCA/LAMA3/GH1/PPP2R2A/MDM2/IL6R/LAMA1/ITGA6/NTF3/CRTC2/STK11/PRKAA1/COL1A2/RPS6KB1/ATF6B/ITGB4/CHRM1/ERBB4/IL2RA/CDC37/CREB3L4/CDKN1A/NTRK1/FGF17/NR4A1/PCK2/IKBKG/ITGB8/MAPK1/OSMR/BDNF/BRCA1/ANGPT1/BCL2L1/ITGA2B/PPP2R3C/FGF6/CDK6/JAK1/PGF/PTEN	186
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	34/3489	49/8135	0.000155	0.003636	0.002624	CYB5R2/GFPT2/PGM2/HEXB/CMAS/NPL/TSTA3/HEXA/GMPPA/NANP/CYB5R1/GMDS/HK3/UAP1/UGP2/GNPDA1/GCK/UGDH/NANS/GNE/GPI/RENBP/CYB5R3/GALK2/MPI/UAP1L1/NAGK/PGM3/GFPT1/CHIT1/PGM1/UXS1/HK1/GALK1	34
KEGG	hsa04530	Tight junction	96/3489	169/8135	0.0001633	0.003636	0.002624	CLDN1/MARVELD2/CGN/TUBA4A/CD1A/ARPC5L/CLDN8/HCLS1/DLG3/ARHGEF2/ARPC1B/TJP1/RAB8B/OCLN/F11R/TJP3/AMOTL1/CLDN10/CLDN4/PRKACB/CRB3/LLGL2/WAS/PPP2R2C/RAB13/DLG2/EZR/BVES/PRKCZ/TIAM1/JAM2/MAGI1/VASP/MARVELD3/PRKCI/MPDZ/PARD3/TJP2/PPP2CA/CD1D/PRKAG2/ARPC1A/MYH14/NEDD4/MPP5/ARPC5/RHOA/MYL9/DLG1/CFTR/TJAP1/PCNA/ACTN1/PRKACA/CACNA1D/ACTR3C/RAP2C/MSN/PPP2R2B/CLDN16/ROCK1/CLDN19/MPP4/MAPK8/PARD6B/CD1E/CLDN5/CDK4/CD1B/ARPC2/PARD6A/HSPA4/TUBA1A/PPP2R2A/STK11/CD1C/PRKAA1/TUBA3C/ROCK2/MYH9/MYL2/MAP3K1/CTTN/CLDN23/MYL12B/WHAMM/CLDN7/RUNX1/JAM3/RAP1A/ARHGAP17/MYH10/CLDN3/NF2/SYMPK/ACTR2	96
KEGG	hsa05146	Amoebiasis	62/3489	102/8135	0.0001902	0.003798	0.002741	CD1A/ARG1/COL4A5/TLR4/SERPINB3/LAMB1/SERPINB13/ITGAM/CD14/LAMC2/ITGB2/PRKACB/COL4A1/LAMB4/COL4A2/TGFB1/COL4A6/FN1/LAMC1/LAMA4/PLCB2/TGFB3/SERPINB6/RAB5C/IL10/RAB5A/GNAQ/CASP3/LAMB2/CD1D/ADCY1/SERPINB4/LAMC3/TLR2/LAMB3/GNAS/RAB5B/ACTN1/PRKACA/PIK3CD/IL1R2/NFKB1/RAB7B/TGFB2/C9/COL3A1/CD1E/SERPINB10/CD1B/HSPB1/PIK3R3/PRKCA/LAMA3/LAMA1/CD1C/GNA15/COL1A2/VCL/PRKCB/MUC2/GNA14/CSF2	62
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	50/3489	79/8135	0.0001933	0.003798	0.002741	FGFR3/ERBB3/HGF/FGFR2/GRB2/PDGFD/BRAF/TGFA/HRAS/AXL/PDGFB/AKT3/IGF1/RAF1/PDGFRA/MAP2K1/PDGFRB/GSK3B/PDGFC/AKT1/SHC3/PIK3CD/EGF/KDR/SHC1/SHC4/RPS6/MTOR/BAX/NRG1/GAB1/EGFR/EIF4E/EIF4EBP1/PDGFA/BCL2L11/RPS6KB2/PIK3R3/PRKCA/IL6R/NRG2/RPS6KB1/PLCG1/PRKCB/GAS6/MAPK1/BCL2L1/JAK1/ARAF/PTEN	50
KEGG	hsa04072	Phospholipase D signaling pathway	85/3489	148/8135	0.0002304	0.004275	0.003086	LPAR3/FYN/FCER1G/GNA12/PLD1/AGPAT4/RRAS/FCER1A/RAPGEF4/AGPAT1/PIK3R5/PLA2G4F/GRB2/PDGFD/PLCB2/DNM1/HRAS/PLA2G4C/PDGFB/AKT3/PIK3CG/KIT/LPAR4/RAF1/PDGFRA/RAPGEF3/F2R/CYTH4/PIK3R6/PIP5K1C/SPHK2/GRM2/DGKA/MAP2K1/ADCY4/PDGFRB/ADCY1/AVPR2/DGKD/RHOA/PDGFC/AKT1/SHC3/AGT/GNAS/PLA2G4D/ADCY2/DGKI/PIK3CD/LPAR1/EGF/MRAS/SHC1/SHC4/MTOR/SYK/CYTH1/GAB2/PTGFR/GAB1/EGFR/PIP5K1A/PDGFA/DGKZ/ADCY8/PIK3R3/PRKCA/ADCY9/CYTH3/CYTH2/ADCY6/PLCG1/ARF6/SPHK1/AGTR1/GRM3/RALB/CXCR1/PTK2B/GRM7/MAPK1/CXCR2/AGPAT2/DGKG/DNM3	85
KEGG	hsa05130	Pathogenic Escherichia coli infection	109/3489	197/8135	0.0002525	0.004439	0.003203	CLDN1/MYO5B/TUBA4A/TLR4/ARPC5L/CLDN8/HCLS1/FYN/IL18/GNA12/WIPF1/ARHGEF2/FCGR2A/ARPC1B/TJP1/NCKAP1L/OCLN/MYO6/MYO1F/CLDN10/BAIAP2L1/CLDN4/ARHGEF11/MAPK13/MYO10/CASP9/EZR/TUBB2A/TAB3/MAPK12/ABL1/LPAR4/F2R/PTPN6/CASP3/CYTH4/MYO1G/CYFIP2/TNFRSF10B/FOS/MAP3K7/ARPC1A/WIPF3/TUBB3/MYH14/NCL/TLR5/ARPC5/RHOA/SEC24D/TUBB2B/BAIAP2/PAK2/ABI1/FASLG/NAIP/LPAR1/ACTR3C/TMBIM6/NFKB1/NLRP3/RPS3/CLDN16/CYCS/MYO1D/TNFSF10/MAPK11/BAX/CYTH1/ROCK1/RAB1A/CLDN19/NCK1/PYCARD/MAPK8/CLDN5/SEC24B/ARPC2/TNFRSF1A/TUBA1A/CYTH3/RIPK1/WIPF2/MYO1C/CYTH2/MYO1E/TUBA3C/TUBB1/ROCK2/MYH9/WASF2/NFKBIA/ARF6/FADD/ABCF2/CTTN/MAPK14/CLDN23/MYO1A/MYO1H/CLDN7/IKBKG/MAPK1/MYH10/PAK1/CLDN3/CYFIP1/ACTR2/TRADD	109
KEGG	hsa05132	Salmonella infection	134/3489	249/8135	0.0002765	0.004618	0.003333	PIK3C2G/TUBA4A/DYNC1LI1/TLR4/ARPC5L/LY96/IL18/PKN1/ARPC1B/NCKAP1L/PFN4/MAP2K4/MYO6/CD14/RRAS/DYNLL1/NLRC4/MAPK13/KLC3/S100A10/ELMO1/PTPRC/TUBB2A/PIK3C2B/MYC/HRAS/TAB3/AKT3/PIK3CG/RAB5C/RHOH/MAPK12/RAB5A/RAF1/RHOJ/RILP/MLKL/CASP3/CYTH4/AHNAK2/FHOD1/HSP90B1/ARL8B/CYFIP2/MAP2K1/TNFRSF10B/FLNA/FOS/MAP3K7/ARPC1A/TLR6/GSDMD/M6PR/DCTN3/TUBB3/DYNLRB2/TLR5/ARPC5/SNX9/RHOA/MYL9/TLR2/DYNC1I1/AKT1/CSE1L/PODXL/TUBB2B/VPS18/SNX33/DYNLT1/PFN2/SNX18/ABI1/NAIP/RHOG/RAB5B/PIK3CD/ACTR3C/PFN1/GCC2/TXN/NFKB1/NLRP3/RPS3/CYCS/ARL8A/TNFSF10/MAPK11/BAX/CYTH1/RAB7B/PYCARD/MAPK8/RIPK2/SKP1/FYCO1/DCTN5/FLNC/ARPC2/TNFRSF1A/KLC4/KPNA3/FBXO22/TUBA1A/CYTH3/RIPK1/FLNB/DYNLT3/CYTH2/DCTN6/TUBA3C/ELMO2/RAB9B/TUBB1/ROCK2/NFKBIA/ARF6/FADD/MYL5/MYL2/MAPK14/MYL12B/RIPK3/NOD1/TCF7L2/IKBKG/MAPK1/PAK1/EXOC7/TCF7L1/CYFIP1/ACTR1A/ACTR2/TRADD	134
KEGG	hsa04662	B cell receptor signaling pathway	51/3489	82/8135	0.000314	0.0048	0.003464	FCGR2B/VAV3/LILRB5/LILRB1/VAV1/PIK3AP1/LILRB3/RASGRP3/BTK/LILRB4/LILRB2/GRB2/LILRA6/HRAS/LILRA2/AKT3/RAC2/CD22/CD81/NFATC1/RAF1/PTPN6/INPP5D/MAP2K1/CD72/FOS/CD79A/INPPL1/PPP3CC/MALT1/LILRA1/DAPP1/GSK3B/LILRA5/AKT1/LILRA3/PIK3CD/BCL10/LYN/NFKB1/SYK/CD19/IFITM1/NFKBIE/PIK3R3/NFATC3/NFKBIA/PRKCB/IKBKG/MAPK1/NFATC2	51
KEGG	hsa04926	Relaxin signaling pathway	75/3489	129/8135	0.0003162	0.0048	0.003464	COL4A5/GNAI1/TGFBR2/GNAI2/VEGFC/MAP2K4/ARRB1/GNG10/CREB3L2/PRKACB/COL4A1/MAPK13/ARRB2/COL4A2/GRB2/GNG2/TGFB1/COL4A6/GNB3/PLCB2/PRKCZ/CREB3/GNAI3/HRAS/CREB5/AKT3/MAPK12/RAF1/TGFBR1/GNG11/MAP2K1/FOS/ADCY4/ADCY1/VEGFB/AKT1/GNB4/GNG7/SHC3/CREB3L1/GNAS/ADCY2/PRKACA/PIK3CD/MMP13/SHC1/NFKB1/SHC4/INSL3/MAPK11/COL3A1/GNB1/MAPK8/NOS1/MMP9/EGFR/MMP2/GNGT2/ADCY8/GNG5/PIK3R3/PRKCA/ADCY9/RLN2/GNA15/RXFP2/ADCY6/COL1A2/ATF6B/NFKBIA/INSL5/CREB3L4/MAPK14/EDN1/MAPK1	75
KEGG	hsa04115	p53 signaling pathway	46/3489	73/8135	0.0003993	0.005717	0.004126	PERP/SFN/TP53AIP1/SERPINB5/CCNE2/CASP9/GORAB/EI24/PMAIP1/SERPINE1/IGF1/CASP3/TNFRSF10B/CCNB1/CCNE1/SHISA5/TP53I3/BID/SIAH1/TP73/APAF1/CDK1/CYCS/CHEK1/RPRM/CCNB2/BAX/PPM1D/MDM4/CDK4/GADD45A/CCND2/GTSE1/MDM2/ZMAT3/CDKN2A/DDB2/GADD45G/AIFM2/STEAP3/CDKN1A/RRM2/RRM2B/BCL2L1/CDK6/PTEN	46
KEGG	hsa04014	Ras signaling pathway	125/3489	232/8135	0.0004108	0.005717	0.004126	FGFR3/PAK6/PLA2G3/CALML5/EFNA1/CSF1R/CALML3/EFNA3/CALM3/RASAL1/RALBP1/EFNA4/CSF1/PLD1/RGL1/VEGFC/GNG10/RASGRP3/RRAS/RASGRP1/ETS1/PRKACB/HGF/FGFR2/RASGRP2/PLA2G4F/GRB2/GNG2/PDGFD/GNB3/ETS2/NTF4/TIAM1/FGF18/TGFA/HRAS/PLA2G4C/PDGFB/AKT3/RAB5C/PLA2G2A/IGF1/ABL1/RAC2/KIT/RAB5A/RASAL3/RAF1/ANGPT2/PDGFRA/REL/GNG11/MAP2K1/PDGFRB/EPHA2/VEGFB/FLT4/RHOA/PDGFC/FLT1/TEK/AKT1/GNB4/RAP1B/GNG7/SHC3/FGF10/PLA2G4D/PAK2/FASLG/RAB5B/PRKACA/PIK3CD/RASGRP4/EGF/PLA2G2F/MRAS/FGFR1/KDR/FLT3LG/SHC1/NFKB1/BRAP/SHC4/PLA2G2D/RASGRF2/GAB2/GNB1/MAPK8/SYNGAP1/GAB1/EGFR/GNGT2/PDGFA/PLA2G12A/ABL2/GNG5/PIK3R3/RASSF1/PRKCA/PLA2G1B/NTF3/HTR7/RASAL2/PLCG1/ARF6/PRKCB/ZAP70/CALM2/RAPGEF5/RALB/NTRK1/RASA3/FGF17/IKBKG/RIN1/RAP1A/MAPK1/RASA1/BDNF/PAK1/ANGPT1/BCL2L1/FGF6/PGF	125
KEGG	hsa04380	Osteoclast differentiation	74/3489	128/8135	0.0004368	0.005773	0.004166	CSF1R/TYROBP/NCF4/FYN/FCGR2B/LILRB5/CSF1/TREM2/LILRB1/FCGR2C/FCGR2A/TGFBR2/LILRB3/CYBA/BTK/LILRB4/LILRB2/MAPK13/OSCAR/GRB2/TGFB1/LILRA6/SPI1/TNFSF11/IFNAR2/LILRA2/LCP2/AKT3/MAPK12/IFNAR1/SQSTM1/NFATC1/TNFRSF11B/TGFBR1/SIRPA/MAP2K1/FOS/MAP3K7/SIRPB1/PPP3CC/FCGR1A/LILRA1/FOSB/ITGB3/NCF2/LILRA5/AKT1/LILRA3/PIK3CD/NFKB1/SYK/MAPK11/TGFB2/ACP5/GAB2/LCK/MAPK8/TEC/CTSK/PIK3R3/TNFRSF1A/MAP3K14/JUNB/SIRPG/FOSL2/NFKBIA/FOSL1/MAPK14/TYK2/IKBKG/MAPK1/PPARG/NFATC2/JAK1	74
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	120/3489	222/8135	0.0004494	0.005773	0.004166	HLA-DMA/TLN1/CD4/SLC2A1/TGFBR2/NRP1/MAP2K4/CCNE2/CREB3L2/SLC25A5/HLA-DMB/ETS1/ITGB2/PRKACB/TGFB1/BUB1B/MAP3K3/ETS2/FDPS/SPI1/MYC/CREB3/TGFB3/HRAS/PTTG1/CREB5/AKT3/POLB/CDKN2B/NFATC1/IL2RG/CDC20/IL15/ELK4/TGFBR1/CD3E/E2F3/MAP2K1/ITGAL/STAT5A/FOS/ADCY4/CDC27/ADCY1/CCNE1/PPP3CC/HLA-C/CD40/MAD2L1/DLG1/AKT1/NFATC4/CREB3L1/ADCY2/CANX/HLA-DRB1/PRKACA/PIK3CD/IL1R2/HLA-DPA1/NFKB1/ESPL1/CHEK1/CCNB2/BAX/TGFB2/CD3D/HLA-F/CCNA2/LCK/EGR1/RAN/MAPK8/HLA-DOA/TLN2/MSX2/CDK4/VDAC1/CDC26/SMAD3/HLA-DRA/EP300/HLA-B/CCND2/CD3G/ADCY8/PIK3R3/TNFRSF1A/SRF/ANAPC10/MAP3K14/ADCY9/RB1/TERT/CRTC2/HLA-G/HLA-A/CDKN2A/ADCY6/ICAM1/ANAPC7/ATF6B/NFATC3/NFKBIA/B2M/ZFP36/IL2RA/MAP3K1/CREB3L4/CDKN1A/FOSL1/RANBP3/STAT5B/IKBKG/MAPK1/BCL2L1/NFATC2/CSF2/JAK1/PTEN	120
KEGG	hsa05165	Human papillomavirus infection	171/3489	331/8135	0.0006412	0.007652	0.005523	ATP6V1C2/ITGA2/WNT16/ITGB6/COL4A5/CSNK1A1/ATP6V0A4/DLG3/PPP2R3A/LAMB1/WNT3/FZD6/CCNE2/CREB3L2/HES1/ITGA5/SPP1/LAMC2/COL6A1/PRKACB/COL4A1/CRB3/LAMB4/COL4A2/RBPJ/LLGL2/PPP2R2C/FZD2/GRB2/COL6A2/MFNG/DLG2/THBS3/COL4A6/FN1/WNT4/LAMC1/THBS4/LAMA4/TCIRG1/PRKCZ/PTGER4/CREB3/COL6A3/HRAS/IFNAR2/CREB5/NOTCH2/AKT3/MAGI1/IFNAR1/FZD3/RAF1/ATP6V0E1/ITGB5/CASP3/LAMB2/PRKCI/MAP2K1/PARD3/PPP2CA/PDGFRB/CCNE1/VWF/ITGA4/ITGA10/LAMC3/RELN/HLA-C/MPP5/ITGB3/GSK3B/DLG1/ITGA9/PXN/HES2/LAMB3/AKT1/HEYL/WNT5B/COL9A3/JAG1/CREB3L1/TNC/FZD4/GNAS/WNT5A/FASLG/WNT2B/ITGA11/PRKACA/PIK3CD/COMP/FOXO1/EGF/NOTCH4/HES5/NFKB1/PPP2R2B/HEY2/MTOR/ATP6AP1/BAX/HLA-F/ATP6V0E2/IBSP/IFNA1/CCNA2/PARD6B/ATP6V1C1/ATP6V1G1/ATP6V0A2/WNT10A/CDK4/EGFR/EIF4EBP1/RPS6KB2/EP300/ITGA7/WNT7B/HLA-B/CCND2/ATP6V1B1/ITGA3/PIK3R3/TNFRSF1A/LAMA3/PARD6A/PPP2R2A/MDM2/LAMA1/RB1/WNT7A/ITGA6/TUBG1/TERT/ATP6V0B/HLA-G/HLA-A/COL1A2/RPS6KB1/HDAC1/ITGB4/IRF3/FZD1/RFNG/FADD/CREB3L4/CDKN1A/WNT1/ATP6V1G2/TYK2/HDAC2/TCF7L2/MAML2/ATP6V1A/IKBKG/ITGB8/MAPK1/TLR3/TADA3/TCF7L1/ITGA2B/FZD8/PPP2R3C/HES4/CDK6/JAK1/TRAF3/PTEN/TRADD	171
KEGG	hsa05220	Chronic myeloid leukemia	47/3489	76/8135	0.0006415	0.007652	0.005523	TGFBR2/GRB2/TGFB1/BRAF/MYC/TGFB3/HRAS/AKT3/ABL1/CTBP2/RAF1/TGFBR1/E2F3/MAP2K1/STAT5A/AKT1/SHC3/PIK3CD/CBL/SHC1/NFKB1/SHC4/POLK/BAX/TGFB2/GAB2/CDK4/SMAD3/GADD45A/PIK3R3/MDM2/RB1/MECOM/CDKN2A/HDAC1/NFKBIA/DDB2/GADD45G/CDKN1A/STAT5B/HDAC2/IKBKG/RUNX1/MAPK1/BCL2L1/CDK6/ARAF	47
KEGG	hsa05205	Proteoglycans in cancer	111/3489	205/8135	0.0006663	0.007674	0.005539	ITGA2/WNT16/ANK3/TLR4/HCLS1/VAV3/ERBB3/SDC1/WNT3/VAV1/SDC2/FZD6/ITGA5/CD63/RRAS/PRKACB/MAPK13/HGF/HSPG2/FZD2/GRB2/TGFB1/FN1/EZR/BRAF/PDCD4/WNT4/MYC/TIAM1/HRAS/SDC4/TIMP3/AKT3/IGF1/MAPK12/ANK1/FZD3/RAF1/ITGB5/PTPN6/CASP3/MAP2K1/FLNA/HPSE/ITGB3/RHOA/TLR2/PXN/AKT1/PLAUR/LUM/WNT5B/ITPR3/PLAU/FZD4/WNT5A/CAMK2A/FASLG/WNT2B/PRKACA/PIK3CD/CBL/MRAS/FGFR1/KDR/NANOG/MSN/RPS6/MTOR/MAPK11/PPP1CB/ROCK1/TGFB2/HSPB2/MMP9/WNT10A/GPC1/GAB1/CAV1/EGFR/MMP2/ITPR1/RPS6KB2/WNT7B/FLNC/PIK3R3/PRKCA/ITPR2/MDM2/WNT7A/FLNB/COL1A2/TWIST1/RPS6KB1/ROCK2/PLCG1/FZD1/ERBB4/PRKCB/MIR21/HOXD10/CTTN/CDKN1A/MAPK14/WNT1/SLC9A1/GPC3/MAPK1/PAK1/FZD8/ARAF	111
KEGG	hsa05222	Small cell lung cancer	55/3489	92/8135	0.0007675	0.0085	0.006134	ITGA2/COL4A5/LAMB1/CCNE2/LAMC2/COL4A1/LAMB4/COL4A2/SKP2/CASP9/COL4A6/FN1/LAMC1/LAMA4/MYC/AKT3/CDKN2B/CASP3/LAMB2/E2F3/TRAF5/CCNE1/LAMC3/RXRB/LAMB3/AKT1/APAF1/PIK3CD/NFKB1/TRAF4/CYCS/POLK/BAX/CDK4/GADD45A/CKS2/ITGA3/PIK3R3/LAMA3/CKS1B/LAMA1/RB1/ITGA6/NFKBIA/DDB2/GADD45G/MAX/TRAF1/CDKN1A/IKBKG/BCL2L1/ITGA2B/CDK6/TRAF3/PTEN	55
KEGG	hsa04010	MAPK signaling pathway	153/3489	294/8135	0.0008066	0.0085	0.006134	FGFR3/EFNA1/CSF1R/CACNA2D4/EFNA3/EFNA4/ERBB3/EREG/GNA12/CSF1/TGFBR2/MKNK1/VEGFC/MAP2K4/ARRB1/CD14/MAP3K12/RASGRP3/RRAS/RASGRP1/PRKACB/MAPK13/RPS6KA2/HGF/ARRB2/MEF2C/FGFR2/RASGRP2/PLA2G4F/GRB2/TGFB1/PDGFD/BRAF/MAP3K3/NTF4/NLK/MYC/FGF18/TGFA/TGFB3/HRAS/PLA2G4C/PDGFB/AKT3/IL1RAP/HSPA6/DUSP3/IGF1/MAPK12/RAC2/KIT/NFATC1/RAF1/ANGPT2/PDGFRA/CASP3/ELK4/TGFBR1/RPS6KA6/MAP4K3/MAP2K1/FLNA/DUSP2/FOS/PDGFRB/MAP3K7/DUSP7/PPP3CC/DUSP16/EPHA2/AREG/VEGFB/MAPT/FLT4/PDGFC/FLT1/TEK/AKT1/RAP1B/HSPA2/DUSP6/FGF10/PLA2G4D/PAK2/FASLG/CACNA2D2/CACNB1/PRKACA/PTPN7/CACNA1D/RASGRP4/EGF/MRAS/FGFR1/DDIT3/KDR/FLT3LG/NFKB1/MAP4K2/MAPK11/DUSP10/DUSP1/RASGRF2/TGFB2/MAP4K1/MAPKAPK3/CACNB4/DUSP5/MAPK8/MAP3K4/EGFR/MAP3K11/PDGFA/GADD45A/FLNC/STMN1/HSPB1/TNFRSF1A/PRKCA/SRF/MAP4K4/MAP3K14/MAP3K6/FLNB/NTF3/MAP3K13/MECOM/NFATC3/GADD45G/ERBB4/PRKCB/MAX/MAP3K1/MAPK14/MAPKAPK5/NTRK1/FGF17/NR4A1/CACNA1A/IKBKG/CACNB2/TAOK3/RAP1A/MAPK1/RASA1/BDNF/PAK1/MAPK8IP1/ANGPT1/FGF6/PGF/ARAF/TRADD	153
KEGG	hsa04660	T cell receptor signaling pathway	61/3489	104/8135	0.0008143	0.0085	0.006134	PAK6/FYN/CD4/VAV3/VAV1/RASGRP1/MAPK13/GRB2/PTPRC/HRAS/CBLB/LCP2/AKT3/MAPK12/IL10/CD8A/NFATC1/RAF1/PTPN6/CD3E/MAP2K1/FOS/MAP3K7/PPP3CC/MALT1/GSK3B/RHOA/DLG1/ITK/AKT1/PAK2/CD247/PIK3CD/BCL10/NFKB1/CD40LG/MAPK11/CD3D/LCK/NCK1/MAPK8/CDK4/NFKBIE/TEC/CD3G/PIK3R3/CD8B/MAP3K14/CD28/PLCG1/NFATC3/NFKBIA/ZAP70/IL5/MAPK14/IKBKG/MAPK1/ICOS/PAK1/NFATC2/CSF2	61
KEGG	hsa04727	GABAergic synapse	53/3489	89/8135	0.001079	0.01092	0.00788	GLS2/SLC38A1/GNAI1/GABRP/SLC6A11/GNAI2/GNG10/PRKACB/GABRB2/GNG2/GNB3/GNAI3/GNG11/ADCY4/TRAK2/ADCY1/ABAT/GABRR2/PLCL1/SLC6A12/GNB4/SLC38A2/KCNJ6/GABARAPL1/GNG7/ADCY2/GLUL/PRKACA/CACNA1D/GABARAP/GABRQ/GNB1/GABRB1/GNGT2/ADCY8/GNG5/PRKCA/GABBR1/ADCY9/GABBR2/GABRE/ADCY6/GLS/SLC12A5/PRKCB/SLC38A5/GPHN/GAD2/CACNA1A/GABRR1/SLC38A3/SLC32A1/GABARAPL2	53
KEGG	hsa05215	Prostate cancer	57/3489	97/8135	0.00112	0.011	0.00794	TMPRSS2/SPINT1/CCNE2/CREB3L2/FGFR2/GRB2/CASP9/PDGFD/BRAF/CREB3/TGFA/HRAS/CREB5/PDGFB/AKT3/IGF1/ERG/RAF1/PDGFRA/MMP3/HSP90B1/E2F3/MAP2K1/PDGFRB/CCNE1/ETV5/GSK3B/PDGFC/AKT1/ZEB1/PLAU/CREB3L1/GSTP1/PIK3CD/FOXO1/EGF/IL1R2/FGFR1/NFKB1/MTOR/MMP9/EGFR/PDGFA/EP300/PIK3R3/MDM2/RB1/NFKBIA/CREB3L4/CDKN1A/TCF7L2/IKBKG/MAPK1/TCF7L1/ARAF/KLK3/PTEN	57
KEGG	hsa05170	Human immunodeficiency virus 1 infection	112/3489	212/8135	0.002	0.01863	0.01345	PAK6/AP1M2/CALML5/CALML3/TLR4/LIMK2/CALM3/CD4/GNAI1/GNAI2/SAMHD1/GNG10/MAPK13/TNFRSF1B/APOBEC3G/APOBEC3F/GNG2/BST2/CASP9/TAPBP/GNB3/GNAI3/HRAS/AKT3/MAPK12/CCR5/RAC2/NFATC1/RAF1/GNAQ/CUL1/WEE1/CASP3/CD3E/GNG11/MAP2K1/AP1M1/FOS/TRAF5/MAP3K7/CCNB1/PPP3CC/CXCR4/HLA-C/CFL2/TLR2/PXN/AKT1/GNB4/NFATC4/ITPR3/GNG7/BID/PAK2/RBX1/FASLG/CD247/PIK3CD/CDK1/AP1S1/NFKB1/CYCS/MTOR/AP1G1/CHEK1/MAPK11/CCNB2/BAX/CUL4A/CD3D/GNB1/HLA-F/IFNA1/MAPK8/SKP1/GNGT2/ITPR1/RPS6KB2/HLA-B/CD3G/GNG5/AP1G2/PIK3R3/TNFRSF1A/PRKCA/ITPR2/RIPK1/DDB1/HLA-G/APOBEC3C/HLA-A/CFL1/RPS6KB1/PLCG1/IRF3/NFATC3/NFKBIA/CUL5/B2M/PRKCB/FADD/CALM2/MAPK14/APOBEC3B/PTK2B/IKBKG/MAPK1/PAK1/BCL2L1/NFATC2/AP1B1/TRADD	112
KEGG	hsa05214	Glioma	45/3489	75/8135	0.002025	0.01863	0.01345	CALML5/CALML3/CALM3/GRB2/BRAF/CAMK1/TGFA/HRAS/PDGFB/AKT3/IGF1/RAF1/PDGFRA/E2F3/MAP2K1/PDGFRB/AKT1/SHC3/CAMK2A/PIK3CD/EGF/SHC1/SHC4/MTOR/POLK/BAX/CDK4/EGFR/PDGFA/GADD45A/PIK3R3/PRKCA/MDM2/RB1/CDKN2A/PLCG1/DDB2/GADD45G/PRKCB/CALM2/CDKN1A/MAPK1/CDK6/ARAF/PTEN	45
KEGG	hsa01250	Biosynthesis of nucleotide sugars	25/3489	37/8135	0.002094	0.01863	0.01345	GFPT2/PGM2/CMAS/TSTA3/GMPPA/NANP/GMDS/HK3/UAP1/UGP2/GCK/UGDH/NANS/GNE/GPI/GALK2/MPI/UAP1L1/NAGK/PGM3/GFPT1/PGM1/UXS1/HK1/GALK1	25
KEGG	hsa05163	Human cytomegalovirus infection	118/3489	225/8135	0.002158	0.01863	0.01345	CALML5/CALML3/CALM3/GNA12/PTGER2/GNAI1/CCR1/GNAI2/GNG10/CREB3L2/IL10RA/PRKACB/ARHGEF11/MAPK13/GRB2/GNG2/CASP9/TAPBP/AKAP13/GNB3/PLCB2/PTGER4/MYC/CREB3/GNAI3/HRAS/CCL5/CREB5/AKT3/MAPK12/CCR5/RAC2/NFATC1/RAF1/GNAQ/PDGFRA/CASP3/E2F3/GNG11/MAP2K1/ADCY4/TRAF5/ADCY1/PPP3CC/CXCR4/HLA-C/ITGB3/GSK3B/RHOA/PXN/AKT1/GNB4/NFATC4/ITPR3/GNG7/CREB3L1/BID/GNAS/ADCY2/FASLG/PRKACA/PIK3CD/NFKB1/IL10RB/CXCL12/CYCS/MTOR/MAPK11/BAX/ROCK1/GNB1/HLA-F/IFNA1/CCL4/CDK4/EGFR/GNGT2/ITPR1/EIF4EBP1/RPS6KB2/HLA-B/ADCY8/GNG5/PIK3R3/TNFRSF1A/PRKCA/ITPR2/ADCY9/MDM2/IL6R/RIPK1/RB1/HLA-G/HLA-A/CDKN2A/ADCY6/RPS6KB1/ATF6B/ROCK2/IRF3/NFATC3/NFKBIA/B2M/PRKCB/FADD/CALM2/CREB3L4/CDKN1A/MAPK14/PTK2B/IKBKG/MAPK1/CXCR2/PTGER1/NFATC2/CDK6/JAK1/TRADD	118
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	56/3489	97/8135	0.002176	0.01863	0.01345	LIMK2/ARPC5L/FCGR2B/VAV3/PLD1/VAV1/FCGR2A/ARPC1B/HCK/WAS/PLA2G4F/MYO10/PTPRC/PLA2G4C/AKT3/BIN1/VASP/RAC2/RAF1/INPP5D/PIP5K1C/SPHK2/MAP2K1/INPPL1/ARPC1A/FCGR1A/ARPC5/CFL2/AKT1/AMPH/PLA2G4D/PIK3CD/ACTR3C/LYN/SYK/GAB2/ASAP3/PIP5K1A/RPS6KB2/ARPC2/PIK3R3/PRKCA/MARCKSL1/GSN/CFL1/RPS6KB1/PLCG1/WASF2/ARF6/PRKCB/SPHK1/ASAP1/ASAP2/MAPK1/PAK1/ACTR2	56
KEGG	hsa05150	Staphylococcus aureus infection	55/3489	96/8135	0.002993	0.0239	0.01725	DSG1/KRT14/KRT23/KRT10/KRT15/HLA-DMA/KRT17/C1QA/FCGR2B/FPR3/SELPLG/KRT16/FCGR2C/FCGR2A/C1QB/KRT19/C3AR1/ITGAM/C2/C1QC/HLA-DMB/ITGB2/SELP/DEFB1/KRT31/C5AR1/CFI/KRT9/IL10/C1S/KRT33A/DEFB4A/ITGAL/FCGR1A/KRT37/FPR1/C1R/HLA-DRB1/CFB/HLA-DPA1/KRT34/KRT27/KRT20/HLA-DOA/CFD/HLA-DRA/KRT25/MASP2/KRT36/ICAM1/KRT18/PTAFR/C5/KRT32/PLG	55
KEGG	hsa04350	TGF-beta signaling pathway	54/3489	94/8135	0.003002	0.0239	0.01725	BMP7/ACVR2A/TGFBR2/THSD4/TGFB1/MYC/TGFB3/ZFYVE9/NEO1/ACVR1/FBN1/CDKN2B/BMP2/CUL1/TGFBR1/FMOD/PPP2CA/RGMA/TGIF2/TFDP1/RGMB/RHOA/LEFTY2/RBX1/SMAD6/ID3/ROCK1/TGFB2/LTBP1/NBL1/CHRD/NOG/GREM2/BMP5/SKP1/SMAD3/RPS6KB2/EP300/SMAD1/BMPR1B/SMAD7/SMURF2/TGIF1/SMAD9/ID4/BMP8A/RPS6KB1/INHBE/GREM1/ID2/BMPR2/FST/MAPK1/PITX2	54
KEGG	hsa05210	Colorectal cancer	50/3489	86/8135	0.003005	0.0239	0.01725	EREG/TGFBR2/GRB2/CASP9/TGFB1/BRAF/MYC/TGFA/TGFB3/HRAS/AKT3/PMAIP1/MSH2/RAC2/RAF1/CASP3/TGFBR1/MAP2K1/FOS/AREG/GSK3B/RHOA/MSH3/AKT1/PIK3CD/EGF/CYCS/MTOR/POLK/BAX/TGFB2/MAPK8/EGFR/SMAD3/BCL2L11/RPS6KB2/GADD45A/PIK3R3/APPL1/RPS6KB1/MLH1/DDB2/GADD45G/DCC/CDKN1A/RALB/TCF7L2/MAPK1/TCF7L1/ARAF	50
KEGG	hsa05225	Hepatocellular carcinoma	90/3489	168/8135	0.003132	0.02433	0.01756	GSTO2/WNT16/GSTA3/CSNK1A1/WNT3/TGFBR2/FZD6/HGF/GSTA4/FZD2/GRB2/TGFB1/BRAF/WNT4/MYC/TGFA/TGFB3/HRAS/AKT3/SMARCC1/FZD3/RAF1/TGFBR1/E2F3/MAP2K1/MGST2/SMARCB1/GSK3B/AKT1/WNT5B/GSTO1/SHC3/FZD4/GSTP1/WNT5A/WNT2B/PIK3CD/SHC1/SHC4/MTOR/POLK/BAX/TGFB2/FRAT1/MGST3/SMARCD3/GSTT2/WNT10A/GAB1/CDK4/ARID1B/EGFR/ACTL6A/SMAD3/RPS6KB2/GADD45A/WNT7B/ARID2/TXNRD2/PIK3R3/PRKCA/PBRM1/GSTT1/RB1/WNT7A/TERT/NFE2L2/CDKN2A/RPS6KB1/BRD7/PLCG1/FZD1/DDB2/GADD45G/PRKCB/LRP5/CDKN1A/WNT1/TCF7L2/LRP6/MAPK1/GSTM5/HMOX1/TCF7L1/BCL2L1/FZD8/CDK6/DPF1/ARAF/PTEN	90
KEGG	hsa04012	ErbB signaling pathway	49/3489	85/8135	0.004166	0.03092	0.02232	PAK6/ERBB3/EREG/MAP2K4/GRB2/BRAF/MYC/TGFA/HRAS/CBLB/AKT3/ABL1/NRG4/RAF1/NRG3/MAP2K1/STAT5A/AREG/GSK3B/AKT1/SHC3/PAK2/CAMK2A/PIK3CD/CBL/EGF/SHC1/SHC4/MTOR/NRG1/NCK1/MAPK8/GAB1/EGFR/EIF4EBP1/RPS6KB2/ABL2/PIK3R3/PRKCA/NRG2/RPS6KB1/PLCG1/ERBB4/PRKCB/CDKN1A/STAT5B/MAPK1/PAK1/ARAF	49
KEGG	hsa04610	Complement and coagulation cascades	49/3489	85/8135	0.004166	0.03092	0.02232	SERPINB2/C1QA/VSIG4/C1QB/C3AR1/ITGAM/C2/C1QC/F2RL2/ITGB2/THBD/KLKB1/F12/C5AR1/SERPING1/CFI/SERPINE1/A2M/F13A1/PROCR/C4BPB/C1S/F2R/CLU/TFPI/VWF/PLAUR/ITGAX/PLAU/C1R/CD59/F10/CFB/SERPINA1/CR1/C9/CFD/CFHR2/MASP2/CD46/F8/F5/C5/PLG/F11/FGB/SERPINC1/C6/BDKRB2	49
KEGG	hsa03410	Base excision repair	22/3489	33/8135	0.004952	0.03596	0.02595	OGG1/UNG/NEIL3/POLB/PARP3/TDG/POLE2/PARP4/POLD4/MPG/POLE3/PCNA/LIG1/PARP1/POLD3/XRCC1/NEIL1/MUTYH/APEX2/NEIL2/MBD4/POLL	22
KEGG	hsa05416	Viral myocarditis	36/3489	60/8135	0.005498	0.03907	0.0282	CXADR/HLA-DMA/FYN/SGCD/HLA-DMB/CD86/ITGB2/CASP9/SGCB/ABL1/RAC2/CASP3/ITGAL/HLA-C/CD40/BID/HLA-DRB1/PRF1/HLA-DPA1/SGCA/CYCS/CD40LG/HLA-F/HLA-DOA/CAV1/HLA-DRA/HLA-B/ABL2/LAMA1/HLA-G/HLA-A/CD28/ICAM1/MYH7/EIF4G1/DMD	36
KEGG	hsa05212	Pancreatic cancer	44/3489	76/8135	0.005788	0.04009	0.02893	RALBP1/PLD1/TGFBR2/CASP9/TGFB1/BRAF/ARHGEF6/TGFA/TGFB3/AKT3/RAC2/RAD51/RAF1/TGFBR1/E2F3/MAP2K1/AKT1/PIK3CD/EGF/NFKB1/MTOR/POLK/BAX/TGFB2/MAPK8/CDK4/EGFR/SMAD3/RPS6KB2/GADD45A/PIK3R3/RB1/CDKN2A/RPS6KB1/DDB2/GADD45G/CDKN1A/RALB/IKBKG/MAPK1/BCL2L1/CDK6/JAK1/ARAF	44
KEGG	hsa04062	Chemokine signaling pathway	100/3489	192/8135	0.005881	0.04009	0.02893	CXCL14/VAV3/CCL27/VAV1/GNAI1/CCL28/CCR1/GNAI2/ARRB1/GNG10/DOCK2/HCK/PRKACB/ARRB2/PIK3R5/RASGRP2/WAS/GRB2/GNG2/PREX1/FGR/CCL18/BRAF/GNB3/ELMO1/PLCB2/PRKCZ/CCL23/CCL16/TIAM1/CCL21/GNAI3/HRAS/CCL5/AKT3/PIK3CG/CCR5/RAC2/RAF1/CCL22/GNAQ/PIK3R6/GNG11/MAP2K1/PARD3/ADCY4/ADCY1/CXCR4/GSK3B/RHOA/ITK/PXN/AKT1/GNB4/RAP1B/GNG7/SHC3/CXCR5/ADCY2/PRKACA/PIK3CD/CCR10/CCR2/LYN/SHC1/NFKB1/SHC4/CXCL12/CXCR3/CXCL16/ROCK1/CCL19/GNB1/CCL4/GNGT2/ADCY8/GNG5/PIK3R3/CX3CR1/ADCY9/CCR6/CCL7/CXCL5/ADCY6/ROCK2/PLCG1/NFKBIA/CCR4/PRKCB/CCL13/CXCR1/PTK2B/STAT5B/IKBKG/RAP1A/MAPK1/CXCR2/PAK1/CCR7/PF4V1	100
KEGG	hsa05221	Acute myeloid leukemia	39/3489	67/8135	0.008046	0.05375	0.03879	JUP/CSF1R/ITGAM/PIM1/CD14/GRB2/BRAF/SPI1/MYC/RARA/HRAS/AKT3/KIT/RAF1/MAP2K1/STAT5A/FCGR1A/AKT1/DUSP6/PIK3CD/NFKB1/MTOR/CCNA2/PIM2/EIF4EBP1/RPS6KB2/PIK3R3/CEBPA/RUNX1T1/RPS6KB1/BCL2A1/STAT5B/TCF7L2/IKBKG/RUNX1/MAPK1/TCF7L1/CSF2/ARAF	39
KEGG	hsa04371	Apelin signaling pathway	74/3489	139/8135	0.008468	0.05546	0.04002	CDH1/CALML5/CALML3/CALM3/GNAI1/GNAI2/GNG10/RRAS/APLNR/SPP1/PRKACB/MEF2C/PIK3R5/GNG2/GNB3/PLCB2/GNAI3/HRAS/AKT3/PIK3CG/SERPINE1/RAF1/GNAQ/SLC8A1/TGFBR1/PIK3R6/SPHK2/GNG11/MAP2K1/MAP1LC3C/ADCY4/PRKAG2/ADCY1/AKT1/GNB4/ITPR3/GNG7/JAG1/TFAM/ADCY2/MEF2A/PRKACA/MRAS/RPS6/HDAC4/MTOR/GNB1/EGR1/NOS1/GNGT2/ITPR1/SMAD3/RPS6KB2/RYR1/ADCY8/GNG5/PPARGC1A/ITPR2/ADCY9/PIK3R4/PRKAA1/ADCY6/MYLK4/MEF2D/RYR3/RPS6KB1/CALM2/MYL2/SPHK1/BECN1/AGTR1/SLC9A1/MAPK1/SLC8A2	74
KEGG	hsa05340	Primary immunodeficiency	24/3489	38/8135	0.009273	0.05941	0.04287	CD4/BTK/UNG/ADA/PTPRC/RFX5/CD8A/IL2RG/CD3E/CD79A/CD40/CD40LG/CD19/CD3D/LCK/IL7R/CD8B/DCLRE1C/RFXAP/ZAP70/IKBKG/TNFRSF13B/ICOS/AICDA	24
KEGG	hsa04810	Regulation of actin cytoskeleton	111/3489	218/8135	0.009427	0.05941	0.04287	FGFR3/PAK6/ITGA2/ITGB6/LIMK2/ARPC5L/VAV3/GNA12/VAV1/ARPC1B/NCKAP1L/ITGAM/PFN4/ITGA5/RRAS/ITGB2/FGFR2/IQGAP2/FN1/PDGFD/PIP4K2C/EZR/BRAF/ARHGEF6/TIAM1/FGF18/HRAS/PDGFB/RAC2/PIP4K2A/LPAR4/RAF1/PDGFRA/F2R/ITGB5/PIP5K1C/CYFIP2/MAP2K1/ITGAL/PDGFRB/ARPC1A/ITGA4/CXCR4/ITGA10/MYH14/ITGB3/ARPC5/CFL2/RHOA/PDGFC/MYL9/ITGA9/PXN/ITGAX/SSH2/BAIAP2/SSH1/PFN2/FGF10/PAK2/ITGA11/ACTN1/PIK3CD/LPAR1/EGF/ACTR3C/PFN1/MRAS/FGFR1/MSN/ARHGEF4/CXCL12/PPP1CB/ROCK1/EGFR/PIP5K1A/PDGFA/ITGA7/ARPC2/ITGA3/PIK3R3/DIAPH3/ITGA6/GSN/CFL1/MYLK4/CHRM3/VCL/ROCK2/MYH9/ITGB4/CHRM1/WASF2/MYL5/MYL2/MYL12B/SLC9A1/FGF17/ITGB8/MAPK1/SSH3/MYH10/PAK1/GIT1/ITGA2B/DIAPH2/CYFIP1/FGF6/BDKRB2/ARAF/ACTR2	111
KEGG	hsa05414	Dilated cardiomyopathy	53/3489	96/8135	0.009714	0.06008	0.04336	ITGA2/ITGB6/CACNA2D4/SGCD/TNNT2/ITGA5/PRKACB/TGFB1/TNNI3/TGFB3/IGF1/SGCB/ITGB5/SLC8A1/ADCY4/ADCY1/ITGA4/ITGA10/TTN/ITGB3/ITGA9/AGT/GNAS/ADCY2/ATP2A3/CACNA2D2/ITGA11/CACNB1/PRKACA/CACNA1D/SGCA/TGFB2/CACNB4/ITGA7/ADCY8/ITGA3/TPM2/ADCY9/ADRB1/LAMA1/TNNC1/LMNA/ITGA6/ADCY6/ITGB4/MYH7/MYL2/TPM1/CACNB2/ITGB8/DMD/SLC8A2/ITGA2B	53
KEGG	hsa04540	Gap junction	49/3489	88/8135	0.01024	0.06221	0.0449	TUBA4A/GNAI1/TJP1/GNAI2/HTR2A/GJA1/PRKACB/GRB2/PDGFD/PLCB2/TUBB2A/GNAI3/HRAS/PDGFB/RAF1/GNAQ/PDGFRA/MAP2K1/ADCY4/PDGFRB/ADCY1/TUBB3/PDGFC/ITPR3/TUBB2B/GNAS/ADCY2/PRKACA/LPAR1/EGF/CDK1/PRKG1/GJD2/EGFR/ITPR1/PDGFA/CSNK1D/ADCY8/PRKCA/ITPR2/TUBA1A/ADCY9/ADRB1/PRKG2/ADCY6/TUBA3C/TUBB1/PRKCB/MAPK1	49
KEGG	hsa04915	Estrogen signaling pathway	73/3489	138/8135	0.01077	0.06424	0.04636	KRT14/KRT23/KRT10/KRT15/CALML5/CALML3/KRT17/CALM3/KRT16/GNAI1/KRT19/GNAI2/CREB3L2/PRKACB/KRT31/GRB2/FKBP4/PLCB2/CREB3/RARA/KRT9/TGFA/GNAI3/HRAS/CREB5/AKT3/HSPA6/RAF1/GNAQ/KRT33A/HSP90B1/MAP2K1/FOS/ADCY4/ADCY1/KRT37/AKT1/KCNJ6/ITPR3/SHC3/CREB3L1/HSPA2/GNAS/ADCY2/PRKACA/PIK3CD/SHC1/SHC4/KRT34/CTSD/KRT27/KRT20/MMP9/EGFR/MMP2/ITPR1/ADCY8/PIK3R3/KRT25/GABBR1/KCNJ5/ITPR2/ADCY9/KRT36/GABBR2/ADCY6/KRT18/ATF6B/CALM2/KRT32/CREB3L4/MAPK1/NCOA1	73
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	14/3489	20/8135	0.01318	0.07723	0.05574	CHST14/CHST7/CHST11/CHST12/CSGALNACT2/CSGALNACT1/CHPF/CHST15/CHSY3/B4GALT7/XYLT1/B3GAT3/CHPF2/CHST13	14
KEGG	hsa05135	Yersinia infection	72/3489	137/8135	0.01362	0.07837	0.05656	TLR4/ARPC5L/CD4/VAV3/IL18/PKN1/WIPF1/VAV1/FCGR2A/ARPC1B/MAP2K4/ITGA5/NLRC4/MAPK13/RPS6KA2/WAS/FN1/ELMO1/LCP2/AKT3/MAPK12/IL10/CD8A/RAC2/NFATC1/GNAQ/RPS6KA6/PIP5K1C/MAP2K1/FOS/MAP3K7/ARPC1A/ITGA4/WIPF3/ARPC5/GIT2/GSK3B/RHOA/PXN/AKT1/BAIAP2/RHOG/PIK3CD/ACTR3C/NFKB1/NLRP3/MAPK11/ROCK1/LCK/PYCARD/MAPK8/PIP5K1A/ARPC2/PIK3R3/CD8B/WIPF2/ELMO2/ROCK2/PLCG1/IRF3/NFATC3/WASF2/NFKBIA/ARF6/ZAP70/MAPK14/PTK2B/IKBKG/MAPK1/NFATC2/SKAP2/ACTR2	72
KEGG	hsa04141	Protein processing in endoplasmic reticulum	88/3489	171/8135	0.01384	0.07837	0.05656	HSPA4L/YOD1/BAG2/MAN1A1/EDEM2/DNAJC10/DNAJA2/OS9/MBTPS1/SEC63/RAD23B/MAN1C1/HSPA6/UBE2D3/SEC31A/FBXO2/UBE2G1/CUL1/DNAJB1/SEC62/SIL1/ERLEC1/HSP90B1/DERL3/EIF2S1/RRBP1/SSR2/LMAN1/DNAJC5B/SEC24D/HSPA2/UBE4B/SEL1L/UBQLN4/XBP1/MBTPS2/CANX/SEC23A/RBX1/SVIP/DDIT3/CAPN2/PDIA4/PRKCSH/BAX/TRAM1L1/DAD1/VCP/DERL1/UBXN4/MAPK8/EIF2AK4/BAG1/NSFL1C/SKP1/UBXN2A/UBXN8/EDEM3/SEC24B/MAN1B1/DNAJA1/ATXN3/SEC13/PREB/SEC61A1/SSR4/UBE2D4/HERPUD1/NGLY1/SEC31B/NFE2L2/GANAB/DNAJC1/UGGT2/ATF6B/SYVN1/ERN1/DERL2/MOGS/WFS1/RPN2/RNF5/HYOU1/DNAJB11/SAR1A/PPP1R15A/STT3A/UBE2D1	88
KEGG	hsa04918	Thyroid hormone synthesis	42/3489	75/8135	0.01477	0.08221	0.05933	GPX2/ATP1B1/DUOX1/GPX1/GPX7/CREB3L2/PRKACB/GPX8/FXYD2/DUOXA2/PLCB2/CREB3/ATP1B3/CREB5/ATP1A1/DUOX2/GNAQ/HSP90B1/ADCY4/ADCY1/ITPR3/CREB3L1/GNAS/ADCY2/CANX/GSR/PRKACA/PDIA4/TTF2/GPX3/ITPR1/ADCY8/PRKCA/ITPR2/ADCY9/ADCY6/ATF6B/TG/PRKCB/CREB3L4/ATP1B2/ASGR2	42
KEGG	hsa04924	Renin secretion	39/3489	69/8135	0.01522	0.08333	0.06014	CLCA2/CALML5/CLCA4/CALML3/CALM3/PTGER2/GNAI1/GNAI2/PDE1A/PRKACB/ACE/PLCB2/PTGER4/GNAI3/CTSB/KCNMA1/PDE1C/GNAQ/PPP3CC/ITPR3/AQP1/NPR1/AGT/GNAS/EDN3/PRKACA/CACNA1D/KCNJ2/ITPR1/ITPR2/ADRB1/PRKG2/ADORA1/ADCY6/ADCYAP1/CALM2/AGTR1/EDN1/NPPA	39
KEGG	hsa00590	Arachidonic acid metabolism	35/3489	61/8135	0.01563	0.08421	0.06077	ALOX12B/PLA2G3/ALOX12/GPX2/CYP2E1/TBXAS1/GPX1/CYP4F3/PTGS1/GPX7/GGT5/CYP2J2/CBR1/GPX8/PLA2G4F/CYP2U1/PLA2G4C/CYP4F2/PLA2G2A/ALOX15B/EPHX2/CYP2C9/ALOX5/PLA2G4D/PLA2G2F/PLA2G2D/ALOX15/GPX3/PLA2G12A/PTGIS/PLA2G1B/PTGES/AKR1C3/HPGDS/CYP4F8	35
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	11/3489	15/8135	0.01695	0.08986	0.06485	GBGT1/NAGA/FUT1/HEXB/ST3GAL2/FUT2/HEXA/ST3GAL1/A4GALT/GLA/B3GALNT1	11
KEGG	hsa05133	Pertussis	42/3489	76/8135	0.01955	0.102	0.07363	CALML5/CALML3/TLR4/C1QA/CALM3/LY96/GNAI1/C1QB/ITGAM/GNAI2/C2/C1QC/CD14/ITGA5/ITGB2/MAPK13/SERPING1/GNAI3/MAPK12/IL10/C4BPB/C1S/CASP3/IRF8/FOS/CFL2/RHOA/C1R/NFKB1/NLRP3/MAPK11/PYCARD/MAPK8/CXCL5/CFL1/IRF3/CALM2/C5/MAPK14/NOD1/MAPK1/IL23A	42
KEGG	hsa04916	Melanogenesis	54/3489	101/8135	0.02016	0.1031	0.07443	TYRP1/DCT/CALML5/WNT16/CALML3/CALM3/WNT3/TYR/GNAI1/GNAI2/FZD6/CREB3L2/PRKACB/FZD2/WNT4/PLCB2/CREB3/GNAI3/HRAS/KIT/FZD3/RAF1/GNAQ/MAP2K1/ADCY4/ADCY1/GSK3B/WNT5B/CREB3L1/FZD4/GNAS/ADCY2/WNT5A/CAMK2A/WNT2B/PRKACA/WNT10A/EP300/WNT7B/ADCY8/PRKCA/ADCY9/WNT7A/ADCY6/FZD1/PRKCB/CALM2/CREB3L4/WNT1/EDN1/TCF7L2/MAPK1/TCF7L1/FZD8	54
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	39/3489	70/8135	0.02038	0.1031	0.07443	ATP6V1C2/PTPRZ1/ATP6V0A4/TJP1/F11R/MAP2K4/MAPK13/TCIRG1/CCL5/JAM2/MAPK12/ATP6V0E1/CASP3/LYN/NFKB1/ATP6AP1/MAPK11/ATP6V0E2/MAPK8/ATP6V1C1/ATP6V1G1/ATP6V0A2/EGFR/ATP6V1B1/MAP3K14/ATP6V0B/ADAM10/PLCG1/NFKBIA/MAPK14/CXCR1/ATP6V1G2/NOD1/ATP6V1A/IKBKG/JAM3/CXCR2/PAK1/GIT1	39
KEGG	hsa04070	Phosphatidylinositol signaling system	52/3489	97/8135	0.02101	0.1045	0.07543	CDS1/PIK3C2G/IPPK/CALML5/CALML3/IMPA2/CALM3/INPP4A/MTMR1/PIP4K2C/CDS2/PLCB2/PPIP5K1/INPP5B/PIK3C2B/INPP1/PIP4K2A/INPP5D/PIP5K1C/IP6K2/DGKA/INPPL1/ITPKC/PI4KA/DGKD/MTMR4/ITPR3/SYNJ1/DGKI/PIK3CD/MTMR2/MTMR14/ITPKB/ITPR1/PIP5K1A/MTMR6/DGKZ/CDIPT/PIK3R3/PRKCA/ITPR2/INPP4B/ITPK1/PLCZ1/PI4KB/PLCG1/PRKCB/CALM2/IMPA1/IP6K1/DGKG/PTEN	52
KEGG	hsa04145	Phagosome	78/3489	152/8135	0.02128	0.1045	0.07543	ATP6V1C2/TUBA4A/ITGA2/HLA-DMA/DYNC1LI1/TLR4/NCF4/FCGR2B/ATP6V0A4/FCGR2C/SFTPD/FCGR2A/MARCO/ITGAM/CD14/CYBA/ITGA5/HLA-DMB/CYBB/ITGB2/CTSS/COLEC12/THBS3/THBS4/TCIRG1/PLA2R1/TUBB2A/MSR1/RAB5C/MRC2/RAB5A/ATP6V0E1/ITGB5/RILP/TLR6/OLR1/M6PR/CORO1A/TUBB3/FCGR1A/HLA-C/ITGB3/NCF2/TLR2/DYNC1I1/SEC22B/TUBB2B/C1R/CANX/RAB5B/HLA-DRB1/COMP/HLA-DPA1/ATP6AP1/RAB7B/HLA-F/ATP6V0E2/SCARB1/STX7/NOS1/ATP6V1C1/HLA-DOA/ATP6V1G1/ATP6V0A2/HLA-DRA/HLA-B/ATP6V1B1/SEC61A1/TUBA1A/ATP6V0B/HLA-G/HLA-A/LAMP2/TUBA3C/TUBB1/ATP6V1G2/ATP6V1A/STX18	78
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	77/3489	150/8135	0.02181	0.1056	0.0762	CALML5/CALML3/CACNA2D4/ATP1B1/CALM3/PPP2R3A/GNAI1/SCN1B/GNAI2/SCN7A/TNNT2/CREB3L2/RAPGEF4/PRKACB/MAPK13/KCNQ1/PIK3R5/FXYD2/PPP2R2C/PLCB2/TNNI3/CREB3/CREM/GNAI3/ATP1B3/CREB5/AKT3/PIK3CG/ATP1A1/MAPK12/GNAQ/RAPGEF3/SLC8A1/PIK3R6/ADCY4/PPP2CA/ADCY1/AKT1/CREB3L1/AGT/GNAS/ADCY2/ATP2A3/CAMK2A/CACNA2D2/CACNB1/PRKACA/CACNA1D/KCNE1/PPP2R2B/MAPK11/PPP1CB/CACNB4/ADCY8/TPM2/PRKCA/ADCY9/PPP2R2A/ADRB1/TNNC1/ATP2B1/ADCY6/ATF6B/SCN4B/MYH7/CALM2/MYL2/CREB3L4/AGTR1/MAPK14/TPM1/ATP1B2/SLC9A1/CACNB2/MAPK1/SLC8A2/PPP2R3C	77
KEGG	hsa05145	Toxoplasmosis	59/3489	112/8135	0.02259	0.1071	0.0773	HLA-DMA/TLR4/LY96/LAMB1/GNAI1/GNAI2/HLA-DMB/LAMC2/IL10RA/MAPK13/LAMB4/PIK3R5/LDLR/CASP9/TGFB1/LAMC1/LAMA4/GNAI3/TGFB3/AKT3/PIK3CG/HSPA6/MAPK12/IL10/CCR5/CASP3/LAMB2/PIK3R6/ALOX5/MAP3K7/LAMC3/CD40/TLR2/LAMB3/AKT1/HSPA2/HLA-DRB1/HLA-DPA1/PPIF/NFKB1/IL10RB/CYCS/CD40LG/MAPK11/TGFB2/MAPK8/HLA-DOA/HLA-DRA/TNFRSF1A/LAMA3/LAMA1/ITGA6/NFKBIA/MAPK14/TYK2/IKBKG/MAPK1/BCL2L1/JAK1	59
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	48/3489	89/8135	0.02277	0.1071	0.0773	TLR4/CD4/RASGRP1/MAPK13/CSNK2A2/MAP3K3/BATF3/HRAS/AKT3/MAPK12/NFATC1/RAF1/PTPN6/CD3E/MAP2K1/FOS/PPP3CC/EML4/TLR2/AKT1/CD247/PIK3CD/EGF/NFKB1/MTOR/MAPK11/CD3D/LCK/EGFR/NFKBIE/RPS6KB2/CD3G/PIK3R3/CD28/RPS6KB1/PLCG1/NFATC3/NFKBIA/CSNK2A1/ZAP70/CSNK2B/MAPK14/BATF2/IKBKG/MAPK1/NFATC2/JAK1/PTEN	48
KEGG	hsa03430	Mismatch repair	15/3489	23/8135	0.02574	0.1187	0.08568	RFC2/MSH2/RFC5/MLH3/POLD4/MSH3/PCNA/EXO1/LIG1/RPA1/MLH1/POLD3/SSBP1/RFC1/RFC3	15
KEGG	hsa04071	Sphingolipid signaling pathway	62/3489	119/8135	0.02595	0.1187	0.08568	ACER1/SGPP2/SPTLC3/DEGS1/FYN/PPP2R3A/FCER1G/ADORA3/GNA12/PLD1/GNAI1/S1PR3/GNAI2/DEGS2/FCER1A/MAPK13/PPP2R2C/S1PR1/PLCB2/PRKCZ/GNAI3/HRAS/AKT3/MAPK12/SMPD2/RAC2/RAF1/GNAQ/SPHK2/MAP2K1/PPP2CA/RHOA/AKT1/BID/PIK3CD/NFKB1/S1PR2/PPP2R2B/MAPK11/BAX/CTSD/ROCK1/GAB2/SGPL1/MAPK8/PIK3R3/TNFRSF1A/PRKCA/PPP2R2A/ADORA1/ROCK2/PRKCB/SPHK1/SGPP1/MAPK14/S1PR4/MAPK1/PPP2R3C/SPTLC1/BDKRB2/PTEN/TRADD	62
KEGG	hsa05231	Choline metabolism in cancer	52/3489	98/8135	0.02644	0.1193	0.08611	PLD1/WAS/PLA2G4F/GRB2/PDGFD/CHKA/LYPLA1/HRAS/PLA2G4C/PDGFB/AKT3/RAC2/RAF1/PDGFRA/SLC22A3/PIP5K1C/DGKA/SLC44A3/MAP2K1/FOS/PDGFRB/CHPT1/DGKD/SLC44A5/PDGFC/AKT1/PCYT1A/PLA2G4D/DGKI/PIK3CD/EGF/SLC44A2/MTOR/MAPK8/EGFR/EIF4EBP1/PIP5K1A/PDGFA/RPS6KB2/DGKZ/PIK3R3/PRKCA/CHKB/RPS6KB1/PLCG1/WASF2/PRKCB/SLC44A1/SLC22A4/MAPK1/DGKG/SLC44A4	52
KEGG	hsa04520	Adherens junction	39/3489	71/8135	0.02684	0.1193	0.08611	CDH1/FYN/SSX2IP/TGFBR2/TJP1/PTPRB/CSNK2A2/WAS/NLK/PTPRM/PTPRF/LMO7/CTNND1/RAC2/PTPN6/TGFBR1/PARD3/YES1/MAP3K7/FARP2/RHOA/BAIAP2/ACTN1/FGFR1/PTPN1/EGFR/SMAD3/EP300/VCL/WASF2/CSNK2A1/CSNK2B/FER/TCF7L2/PTPRJ/MAPK1/SNAI1/TCF7L1/SNAI2	39
KEGG	hsa05211	Renal cell carcinoma	38/3489	69/8135	0.02728	0.1193	0.08611	PAK6/SLC2A1/ETS1/HGF/RAPGEF1/EGLN3/GRB2/TGFB1/BRAF/TGFA/TGFB3/HRAS/PDGFB/AKT3/RAF1/MAP2K1/ARNT/CUL2/AKT1/RAP1B/PAK2/RBX1/PIK3CD/TFE3/TGFB2/FH/VHL/GAB1/FLCN/EP300/PIK3R3/EGLN1/CDKN1A/EPAS1/RAP1A/MAPK1/PAK1/ARAF	38
KEGG	hsa05224	Breast cancer	75/3489	147/8135	0.02751	0.1193	0.08611	WNT16/CSNK1A1/DLL1/WNT3/FZD6/HES1/FZD2/GRB2/BRAF/WNT4/TNFSF11/MYC/FGF18/HRAS/NOTCH2/AKT3/IGF1/KIT/FZD3/RAF1/E2F3/MAP2K1/FOS/FLT4/GSK3B/AKT1/HEYL/WNT5B/JAG1/SHC3/FZD4/FGF10/WNT5A/WNT2B/PIK3CD/EGF/NOTCH4/FGFR1/HES5/SHC1/SHC4/HEY2/MTOR/POLK/BAX/FRAT1/WNT10A/CDK4/EGFR/RPS6KB2/GADD45A/WNT7B/PIK3R3/RB1/WNT7A/RPS6KB1/FZD1/DDB2/GADD45G/LRP5/CDKN1A/WNT1/FGF17/TCF7L2/JAG2/LRP6/MAPK1/BRCA1/TCF7L1/FZD8/FGF6/CDK6/NCOA1/ARAF/PTEN	75
KEGG	hsa05418	Fluid shear stress and atherosclerosis	71/3489	139/8135	0.03044	0.128	0.09239	GSTO2/CALML5/CALML3/GSTA3/CALM3/ACVR2A/SDC1/ARHGEF2/SDC2/MAP2K4/CYBA/MAPK13/THBD/MEF2C/GSTA4/PECAM1/PRKCZ/CDH5/SDC4/PDGFB/AKT3/VCAM1/ACVR1/MAPK12/RAC2/SQSTM1/SUMO3/HSP90B1/FOS/MAP3K7/MGST2/ITGB3/RHOA/NCF2/AKT1/GSTO1/GSTP1/MEF2A/PIK3CD/IL1R2/KDR/TXN/NFKB1/MAPK11/DUSP1/MGST3/MAPK8/GSTT2/MMP9/GPC1/CAV1/MMP2/PDGFA/BMPR1B/PIK3R3/TNFRSF1A/GSTT1/NFE2L2/PRKAA1/ICAM1/BMPR2/CALM2/MAPK14/SUMO2/EDN1/IKBKG/ASS1/GSTM5/HMOX1/ITGA2B/SELE	71
KEGG	hsa04310	Wnt signaling pathway	84/3489	167/8135	0.03078	0.128	0.09239	RNF43/VANGL2/WNT16/CSNK1A1/FRZB/WNT3/RSPO1/VANGL1/FZD6/RSPO3/DKK2/PRKACB/CSNK2A2/FZD2/CTNNBIP1/WNT4/PLCB2/NLK/MYC/ZNRF3/LGR5/SFRP4/SERPINF1/LGR6/CTBP2/RAC2/FZD3/NFATC1/CUL1/DAAM2/DAAM1/MAP3K7/ROR1/PPP3CC/NKD2/RSPO2/GSK3B/RHOA/SOX17/WNT5B/NFATC4/WIF1/FZD4/SIAH1/WNT5A/CAMK2A/GPC4/RBX1/WNT2B/PRKACA/TLE4/FRAT1/MAPK8/WNT10A/CHD8/TLE3/SKP1/TBL1X/SMAD3/EP300/WNT7B/CCND2/PRKCA/CSNK1E/ROR2/WNT7A/ROCK2/NFATC3/FZD1/CSNK2A1/PRKCB/CSNK2B/LRP5/FOSL1/PRICKLE1/WNT1/SENP2/TCF7L2/LRP6/TLE2/TCF7L1/FZD8/NFATC2/CACYBP	84
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	22/3489	37/8135	0.03104	0.128	0.09239	GLS2/GFPT2/FOLH1/GPT2/DDO/GOT2/ALDH5A1/GOT1/ABAT/NIT2/GLUL/GPT/ASRGL1/ADSL/ASNS/GFPT1/GLS/AGXT/ALDH4A1/GAD2/ASL/ASS1	22
KEGG	hsa00071	Fatty acid degradation	25/3489	43/8135	0.03127	0.128	0.09239	ACSBG1/ACAT2/ACSL5/CPT1C/CYP2U1/ACSL3/ALDH7A1/ALDH3A2/ACSL4/ADH6/ACAA2/ADH7/ACADSB/ADH1C/ALDH1B1/ACOX3/ACADS/ACSBG2/GCDH/ACSL6/ACOX1/ALDH2/ADH1B/ALDH9A1/ACSL1	25
KEGG	hsa04146	Peroxisome	44/3489	82/8135	0.03143	0.128	0.09239	ABCD3/ACSL5/PEX3/PXMP4/PEX7/ACOT8/CROT/DDO/MPV17/ACSL3/XDH/PMVK/PEX10/HMGCL/AGPS/EPHX2/AMACR/SLC25A17/PEX1/CRAT/ACOX2/ACSL4/ABCD1/ABCD4/FAR1/HSD17B4/NUDT19/MVK/IDH2/ACOX3/PIPOX/PHYH/PEX2/MPV17L/ACSL6/ACOX1/SOD1/PEX6/IDH1/AGXT/MLYCD/ACSL1/FAR2/NUDT12	44
KEGG	hsa05169	Epstein-Barr virus infection	100/3489	202/8135	0.03244	0.1306	0.09423	HLA-DMA/PSMD11/MAP2K4/CCNE2/HES1/BTK/HLA-DMB/ENTPD3/MAPK13/SKP2/RBPJ/CASP9/TAPBP/VIM/MYC/IFNAR2/AKT3/MAPK12/IFNAR1/ENTPD1/CASP3/CD3E/E2F3/ITGAL/PSMD12/NCOR2/TRAF5/MAP3K7/CCNE1/PSMD14/NEDD4/HLA-C/CD40/TLR2/AKT1/USP7/BID/CD247/HLA-DRB1/APAF1/PIK3CD/PSMD7/LYN/HLA-DPA1/SIN3A/NFKB1/CYCS/SYK/POLK/CD19/MAPK11/BAX/CD3D/HLA-F/IFNA1/CCNA2/MAPK8/HLA-DOA/CDK4/SAP30/SAP30L/NFKBIE/BCL2L11/HLA-DRA/GADD45A/PSMC6/HLA-B/CCND2/CD3G/FCER2/PIK3R3/MAP3K14/MDM2/RIPK1/RB1/HLA-G/HLA-A/ICAM1/PSMD6/HDAC1/IRF3/NFKBIA/DDB2/B2M/GADD45G/FADD/CDKN1A/MAPK14/PSMC3/TYK2/HDAC2/IKBKG/PSMD3/CD58/CDK6/JAK1/TRAF3/PSMD2/TRADD/PSMC4	100
KEGG	hsa04971	Gastric acid secretion	41/3489	76/8135	0.03343	0.1324	0.09556	CALML5/CALML3/ATP1B1/CALM3/GNAI1/GNAI2/PRKACB/KCNQ1/CA2/EZR/PLCB2/GNAI3/ATP1B3/ATP1A1/GNAQ/KCNK2/ADCY4/ADCY1/SLC4A2/CFTR/ITPR3/GNAS/ADCY2/CAMK2A/PRKACA/KCNJ2/ITPR1/KCNK10/ADCY8/PRKCA/ITPR2/ADCY9/KCNJ16/ADCY6/MYLK4/CHRM3/PRKCB/CALM2/ATP1B2/SLC9A1/KCNJ1	41
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	67/3489	131/8135	0.0337	0.1324	0.09556	ICAM2/TYROBP/FYN/VAV3/FCER1G/VAV1/KLRK1/HCST/RAET1E/ITGB2/GRB2/BRAF/MICB/HRAS/IFNAR2/LCP2/IFNAR1/RAC2/CD48/NFATC1/RAF1/PTPN6/SH2D1A/CASP3/MAP2K1/ITGAL/TNFRSF10B/PPP3CC/HLA-C/ULBP2/SHC3/BID/FASLG/CD247/PIK3CD/PRF1/MICA/SHC1/SHC4/SYK/TNFSF10/IFNA1/LCK/CD244/KLRD1/HLA-B/PIK3R3/PRKCA/HLA-G/HLA-A/SH3BP2/ICAM1/PLCG1/KIR3DL3/PRKCB/ZAP70/KLRC3/KIR2DL1/GZMB/PTK2B/ULBP1/NCR2/MAPK1/PAK1/NFATC2/CSF2/ARAF	67
KEGG	hsa05218	Melanoma	39/3489	72/8135	0.03479	0.1346	0.09718	CDH1/HGF/PDGFD/BRAF/FGF18/HRAS/PDGFB/AKT3/IGF1/RAF1/PDGFRA/E2F3/MAP2K1/PDGFRB/PDGFC/AKT1/FGF10/PIK3CD/EGF/FGFR1/POLK/BAX/CDK4/EGFR/PDGFA/GADD45A/PIK3R3/MDM2/RB1/CDKN2A/DDB2/GADD45G/CDKN1A/FGF17/MAPK1/FGF6/CDK6/ARAF/PTEN	39
KEGG	hsa05323	Rheumatoid arthritis	49/3489	93/8135	0.03533	0.1346	0.09718	ATP6V1C2/HLA-DMA/TLR4/ATP6V0A4/IL18/CSF1/TNFSF13/HLA-DMB/CD86/ITGB2/TGFB1/TCIRG1/TNFSF11/TGFB3/CCL5/TNFSF13B/ATP6V0E1/MMP3/IL15/ITGAL/FOS/FLT1/TEK/TLR2/IL11/HLA-DRB1/LTB/HLA-DPA1/CXCL12/ATP6AP1/TGFB2/ACP5/ATP6V0E2/ATP6V1C1/HLA-DOA/ATP6V1G1/ATP6V0A2/HLA-DRA/CTSK/ATP6V1B1/ATP6V0B/CXCL5/CD28/ICAM1/ATP6V1G2/ATP6V1A/ANGPT1/IL23A/CSF2	49
KEGG	hsa05230	Central carbon metabolism in cancer	38/3489	70/8135	0.03548	0.1346	0.09718	FGFR3/GLS2/SLC2A1/FGFR2/SLC16A3/MYC/HRAS/HK3/AKT3/PDK1/KIT/RAF1/PDGFRA/SLC7A5/MAP2K1/PDGFRB/GCK/AKT1/PIK3CD/FGFR1/LDHB/MTOR/IDH2/LDHAL6B/EGFR/PFKP/RET/PIK3R3/GLS/SIRT3/IDH1/SLC1A5/NTRK1/PDHB/MAPK1/HK1/LDHA/PTEN	38
KEGG	hsa00511	Other glycan degradation	12/3489	18/8135	0.0363	0.1362	0.09831	FUCA1/HEXB/GLB1/MANBA/FUCA2/HEXA/NEU1/MAN2B2/AGA/MAN2B1/ENGASE/NEU3	12
KEGG	hsa00100	Steroid biosynthesis	13/3489	20/8135	0.03861	0.1433	0.1034	DHCR24/FDFT1/SQLE/DHCR7/CYP2R1/CYP51A1/EBP/NSDHL/HSD17B7/TM7SF2/LSS/SOAT1/CYP24A1	13
KEGG	hsa04972	Pancreatic secretion	53/3489	102/8135	0.03958	0.1446	0.1043	CLCA2/PRSS3/PLA2G3/PRSS2/CLCA4/RAB3D/RAB27B/SLC12A2/RAB11A/ATP1B1/KCNQ1/CA2/BST1/FXYD2/PLCB2/ATP1B3/KCNMA1/ATP1A1/PLA2G2A/CELA2A/GNAQ/CD38/ADCY4/ADCY1/SLC4A2/RHOA/RAP1B/CFTR/ITPR3/GNAS/ADCY2/ATP2A3/PLA2G2F/TRPC1/PLA2G2D/SCTR/ITPR1/PLA2G12A/ADCY8/PRKCA/PLA2G1B/ITPR2/ADCY9/ATP2B1/CTRL/ADCY6/TPCN2/CHRM3/PRKCB/ATP1B2/SLC9A1/CPB1/RAP1A	53
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	52/3489	100/8135	0.04057	0.1446	0.1043	IL20RB/CXCL14/IL22RA1/IL20RA/CSF1R/CCL27/IL18/CSF1/CCL28/CCR1/IL10RA/TNFRSF1B/CCL18/CCL23/CCL16/CCL21/CCL5/IL10/CCR5/IL2RG/CCL22/TNFRSF10B/CXCR4/IL6ST/CXCR5/TNFRSF10C/CCR10/CCR2/IL10RB/CXCL12/TNFRSF14/TNFSF10/CXCR3/CCL19/IL20/CCL4/TNFRSF1A/CX3CR1/TNFRSF10D/IL6R/CCR6/CCL7/CXCL5/CCR4/CCL13/IL2RA/IL18R1/CXCR1/IL19/CXCR2/CCR7/PF4V1	52
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	52/3489	100/8135	0.04057	0.1446	0.1043	COL4A5/NOX4/TGFBR2/PIM1/VEGFC/CYBB/COL4A1/MAPK13/THBD/COL4A2/TGFB1/COL4A6/FN1/PLCB2/PRKCZ/TGFB3/HRAS/AKT3/VCAM1/SERPINE1/MAPK12/NFATC1/CASP3/TGFBR1/STAT5A/VEGFB/AKT1/AGT/PIK3CD/FOXO1/NFKB1/MAPK11/BAX/TGFB2/COL3A1/EGR1/MAPK8/CDK4/MMP2/SMAD3/PIK3R3/PRKCA/ICAM1/COL1A2/PLCG1/PRKCB/AGTR1/MAPK14/EDN1/STAT5B/MAPK1/SELE	52
KEGG	hsa01522	Endocrine resistance	51/3489	98/8135	0.04159	0.1446	0.1043	DLL1/BIK/PRKACB/MAPK13/GRB2/BRAF/HRAS/NOTCH2/AKT3/IGF1/MAPK12/RAF1/E2F3/MAP2K1/FOS/ADCY4/ADCY1/AKT1/JAG1/SHC3/GNAS/ADCY2/PRKACA/PIK3CD/NOTCH4/NCOR1/SHC1/SHC4/MTOR/MAPK11/BAX/MAPK8/MMP9/CDK4/EGFR/MMP2/RPS6KB2/ADCY8/PIK3R3/ADCY9/MDM2/RB1/CDKN2A/ADCY6/RPS6KB1/CDKN1A/MAPK14/CARM1/JAG2/MAPK1/ARAF	51
KEGG	hsa04925	Aldosterone synthesis and secretion	51/3489	98/8135	0.04159	0.1446	0.1043	CALML5/CALML3/ATP1B1/CALM3/CREB3L2/PRKACB/LDLR/CAMK1/PLCB2/CREB3/CYP11A1/ATP1B3/STAR/CREB5/ATP1A1/GNAQ/PRKD1/ADCY4/ADCY1/PDE2A/ITPR3/NPR1/CREB3L1/AGT/GNAS/ADCY2/CAMK2A/PRKACA/CACNA1D/CYP21A2/SCARB1/DAGLA/ITPR1/ADCY8/NR4A2/PRKCA/KCNJ5/ITPR2/ADCY9/ATP2B1/KCNK3/ADCY6/ATF6B/PRKCB/CALM2/CREB3L4/PRKD3/AGTR1/ATP1B2/NR4A1/NPPA	51
KEGG	hsa05110	Vibrio cholerae infection	28/3489	50/8135	0.04199	0.1446	0.1043	ATP6V1C2/SLC12A2/ATP6V0A4/TJP1/PRKACB/KCNQ1/TCIRG1/KDELR3/KDELR1/ATP6V0E1/TJP2/CFTR/GNAS/PRKACA/PDIA4/ATP6AP1/ATP6V0E2/ATP6V1C1/ATP6V1G1/ATP6V0A2/ATP6V1B1/PRKCA/SEC61A1/ADCY9/ATP6V0B/PLCG1/ATP6V1G2/ATP6V1A	28
KEGG	hsa05144	Malaria	28/3489	50/8135	0.04199	0.1446	0.1043	TLR4/IL18/SDC1/SDC2/KLRK1/LRP1/ITGB2/HGF/SELP/PECAM1/TGFB1/THBS3/THBS4/TGFB3/VCAM1/GYPC/IL10/CD81/ITGAL/CD40/TLR2/COMP/CD40LG/CR1/TGFB2/KLRB1/ICAM1/SELE	28
KEGG	hsa04962	Vasopressin-regulated water reabsorption	25/3489	44/8135	0.04348	0.1482	0.1069	AQP3/DYNC1LI1/RAB11A/CREB3L2/DYNLL1/PRKACB/CREB3/CREB5/RAB5C/RAB5A/ARHGDIB/AVPR2/DYNC1I1/CREB3L1/GNAS/RAB5B/PRKACA/STX4/DCTN5/RAB11B/ADCY9/ARHGDIA/ADCY6/DCTN6/CREB3L4	25
KEGG	hsa00512	Mucin type O-glycan biosynthesis	21/3489	36/8135	0.04455	0.1488	0.1074	ST6GALNAC2/GALNT3/GCNT1/GALNT10/C1GALT1C1/B4GALT5/ST3GAL2/ST3GAL1/ST6GALNAC3/C1GALT1/GALNT14/GALNT5/GALNT2/ST6GALNAC1/GALNT7/GALNT12/ST6GALNAC4/GALNT6/B3GNT3/GALNT4/GALNTL5	21
KEGG	hsa03030	DNA replication	21/3489	36/8135	0.04455	0.1488	0.1074	MCM4/RNASEH2C/RFC2/RFC5/POLE2/POLD4/RNASEH2B/POLE3/PCNA/MCM2/POLA1/LIG1/MCM6/PRIM2/RPA1/POLD3/PRIM1/SSBP1/RFC1/RFC3/RNASEH1	21
KEGG	hsa05410	Hypertrophic cardiomyopathy	47/3489	90/8135	0.04593	0.1519	0.1096	ITGA2/ITGB6/CACNA2D4/SGCD/TNNT2/ITGA5/ACE/TGFB1/TNNI3/TGFB3/IGF1/SGCB/ITGB5/SLC8A1/PRKAG2/ITGA4/ITGA10/TTN/ITGB3/ITGA9/AGT/ATP2A3/CACNA2D2/ITGA11/CACNB1/CACNA1D/SGCA/TGFB2/CACNB4/ITGA7/ITGA3/TPM2/LAMA1/TNNC1/LMNA/ITGA6/PRKAA1/ITGB4/MYH7/MYL2/TPM1/EDN1/CACNB2/ITGB8/DMD/SLC8A2/ITGA2B	47
KEGG	hsa00010	Glycolysis / Gluconeogenesis	36/3489	67/8135	0.04745	0.1554	0.1121	ALDH3B2/ALDH3A1/GALM/PGM2/G6PC3/ENO2/FBP1/HK3/ALDH7A1/ALDH3B1/ALDH3A2/AKR1A1/GCK/GAPDHS/GPI/ADH6/DLAT/ADH7/LDHB/ADH1C/ALDH1B1/LDHAL6B/PFKP/ALDOC/ADPGK/MINPP1/ENO3/ALDH2/ADH1B/PGM1/ALDH9A1/PCK2/PDHB/HK1/DLD/LDHA	36
KEGG	hsa04974	Protein digestion and absorption	53/3489	103/8135	0.04824	0.1564	0.1129	SLC15A1/COL17A1/PRSS3/PRSS2/COL4A5/ATP1B1/SLC7A7/SLC16A10/COL6A1/COL4A1/COL14A1/KCNQ1/COL4A2/COL7A1/FXYD2/COL6A2/COL4A6/COL5A2/COL6A3/ATP1B3/COL5A1/ATP1A1/CELA2A/SLC1A1/ACE2/SLC8A1/COL28A1/COL11A1/COL12A1/COL5A3/COL8A1/SLC38A2/COL9A3/PRCP/COL15A1/COL24A1/SLC36A1/ELN/COL18A1/MME/KCNJ13/COL3A1/SLC7A9/COL8A2/COL22A1/KCNK5/CTRL/COL1A2/XPNPEP2/ATP1B2/SLC1A5/CPB1/SLC8A2	53
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	95/3489	194/8135	0.04906	0.1565	0.1129	CALML5/CALML3/CALM3/CCR1/MAP2K4/GNG10/HCK/CD86/MAPK13/PIK3R5/GNG2/PREX1/CASP9/MICB/GNB3/MYC/HRAS/IFNAR2/PDGFB/AKT3/PIK3CG/MAPK12/CCR5/IFNAR1/NFATC1/RAF1/ANGPT2/CASP3/PIK3R6/E2F3/GNG11/MAP2K1/MAP1LC3C/FOS/PPP3CC/HLA-C/CD200R1/GSK3B/AKT1/GNB4/NFATC4/ITPR3/GNG7/IL6ST/CLEC2B/BID/PIK3CD/LYN/MICA/NFKB1/CYCS/MTOR/SYK/MAPK11/BAX/GNB1/HLA-F/IFNA1/MAPK8/CDK4/GNGT2/ITPR1/EP300/HLA-B/GNG5/PIK3R3/TNFRSF1A/ITPR2/RB1/HLA-G/HLA-A/ICAM1/PLCG1/IRF3/NFATC3/NFKBIA/CCR4/ZFP36/FADD/CALM2/BECN1/CDKN1A/MAPK14/TYK2/TCF7L2/IKBKG/MAPK1/TLR3/TCF7L1/NFATC2/CSF2/CDK6/JAK1/TRAF3/TRADD	95
KEGG	hsa04068	FoxO signaling pathway	66/3489	131/8135	0.0492	0.1565	0.1129	HOMER2/HOMER1/TGFBR2/PLK2/G6PC3/MAPK13/SKP2/GRB2/TGFB1/BRAF/S1PR1/PLK4/NLK/TGFB3/HRAS/AKT3/IGF1/MAPK12/IL10/CDKN2B/RAF1/TGFBR1/MAP2K1/PRKAG2/ATG12/CCNB1/AKT1/GABARAPL1/USP7/FASLG/PIK3CD/GABARAP/FOXO1/EGF/SGK1/TNFSF10/MAPK11/CCNB2/TGFB2/IL7R/MAPK8/EGFR/SMAD3/BCL2L11/GADD45A/EP300/CCND2/PIK3R3/CSNK1E/MDM2/STK11/PRKAA1/GADD45G/CDKN1A/MAPK14/S1PR4/IRS2/SETD7/PCK2/HOMER3/MAPK1/PLK1/GABARAPL2/FBXO25/ARAF/PTEN	66
KEGG	hsa04934	Cushing syndrome	77/3489	155/8135	0.05077	0.1578	0.1139	WNT16/NCEH1/WNT3/GNAI1/AIP/GNAI2/FZD6/CCNE2/CREB3L2/PRKACB/LDLR/FZD2/BRAF/WNT4/PLCB2/CREB3/CYP11A1/GNAI3/STAR/CREB5/FZD3/CDKN2B/GNAQ/KCNK2/E2F3/MAP2K1/ADCY4/ADCY1/CCNE1/ARNT/GSK3B/RAP1B/WNT5B/ITPR3/CREB3L1/FZD4/AGT/GNAS/ADCY2/WNT5A/CAMK2A/WDR5B/WNT2B/PRKACA/CACNA1D/CYP21A2/USP8/FH/SCARB1/WNT10A/CDK4/EGFR/ITPR1/WNT7B/ADCY8/ITPR2/ADCY9/RB1/WNT7A/CDKN2A/KCNK3/ADCY6/ATF6B/PBX1/FZD1/CREB3L4/CDKN1A/AGTR1/WNT1/NR4A1/TCF7L2/RAP1A/MAPK1/TCF7L1/FZD8/CDK6/ARMC5	77
KEGG	hsa05131	Shigellosis	119/3489	247/8135	0.05087	0.1578	0.1139	TLR4/TLN1/ARPC5L/HCLS1/CAPNS1/IL18/ARHGEF2/ARPC1B/PFN4/CD14/ITGA5/NLRC4/MAPK13/ILK/GLMN/ELMO1/PLCB2/CCL5/HK3/TAB3/AKT3/UBE2D3/MAPK12/SQSTM1/CUL1/CYTH4/MAP1LC3C/TRAF5/MAP3K7/ATG12/ARPC1A/MALT1/TIFA/TLR5/ARPC5/GSK3B/RHOA/MYL9/PXN/AKT1/UBE2NL/ITPR3/CAST/PFN2/RBX1/NAIP/ACTN1/PIK3CD/FOXO1/ACTR3C/PFN1/BCL10/CAPN2/NFKB1/NLRP3/CYCS/MTOR/MAPK11/BAX/CYTH1/ROCK1/TECPR1/U2AF1L4/PYCARD/MAPK8/RIPK2/TLN2/SKP1/EGFR/VDAC1/UBE2V2/ITPR1/RPS6KB2/SHARPIN/ARPC2/ATG5/PIK3R3/TNFRSF1A/RRAGC/ITPR2/WIPI1/MDM2/UBE2D4/ATG16L1/CYTH3/RIPK1/PLCZ1/TNIP1/CALCOCO2/PIK3R4/CYTH2/RPS6KB1/UBE2N/ELMO2/VCL/ROCK2/PLCG1/IRF3/WASF2/NFKBIA/ARF6/MYL5/MYL2/BECN1/RRAGB/CTTN/MAPK14/MYL12B/NOD1/IKBKG/MAPK1/RBCK1/HK1/BCL2L1/CSF2/UBE2D1/FNBP1L/ACTR2/TRADD	119
KEGG	hsa04724	Glutamatergic synapse	58/3489	114/8135	0.05103	0.1578	0.1139	HOMER2/HOMER1/GLS2/SLC38A1/PLD1/GNAI1/GNAI2/GNG10/PRKACB/SLC1A6/PLA2G4F/GNG2/GNB3/PLCB2/GNAI3/PLA2G4C/SLC1A1/GNAQ/GRM2/GNG11/ADCY4/ADCY1/PPP3CC/DLG4/GNB4/SLC38A2/ITPR3/GNG7/SLC17A7/GNAS/PLA2G4D/ADCY2/GLUL/PRKACA/CACNA1D/TRPC1/SHANK3/SHANK2/GNB1/GNGT2/ITPR1/ADCY8/GNG5/GRIN2D/PRKCA/ITPR2/ADCY9/SLC1A3/ADCY6/GLS/PRKCB/GRM3/GRM7/CACNA1A/HOMER3/MAPK1/SLC38A3/GRIA2	58
KEGG	hsa05161	Hepatitis B	80/3489	162/8135	0.05454	0.1634	0.1179	EGR3/TLR4/TGFBR2/MAP2K4/CCNE2/CREB3L2/MAPK13/HSPG2/GRB2/CASP9/TGFB1/BRAF/STAT4/MYC/CREB3/TGFB3/HRAS/CREB5/AKT3/YWHAZ/MAPK12/IFNAR1/NFATC1/RAF1/CASP3/TGFBR1/E2F3/MAP2K1/STAT5A/FOS/MAP3K7/CCNE1/TLR2/AKT1/NFATC4/CREB3L1/BID/PCNA/FASLG/APAF1/PIK3CD/NFKB1/CYCS/ATP6AP1/MAPK11/BAX/TGFB2/IFNA1/CCNA2/MAPK8/MMP9/IFIH1/SMAD3/EP300/PIK3R3/PRKCA/DDB1/RB1/ATF6B/IRF3/NFATC3/NFKBIA/DDB2/PRKCB/FADD/MAP3K1/CREB3L4/CDKN1A/MAPK14/CASP10/PTK2B/STAT5B/TYK2/IKBKG/MAPK1/TLR3/NFATC2/JAK1/ARAF/TRAF3	80
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	29/3489	53/8135	0.05479	0.1634	0.1179	KLK1/RAB11A/ATP1B1/CLTB/AP2A2/PRKACB/FXYD2/PLCB2/AP2B1/DNM1/ATP1B3/ATP1A1/AP2M1/GNAQ/SLC8A1/GNAS/PRKACA/PRKCA/ADCY9/KL/ATP2B1/ADCY6/PRKCB/VDR/ATP1B2/PTH1R/SLC8A2/DNM3/BDKRB2	29
KEGG	hsa04210	Apoptosis	68/3489	136/8135	0.05505	0.1634	0.1179	TP53AIP1/TUBA4A/CTSZ/CTSO/DFFB/PTPN13/CTSS/CASP9/HRAS/CTSB/CTSF/AKT3/PMAIP1/PARP3/RAF1/CASP3/MAP2K1/TNFRSF10B/FOS/PARP4/IL3RA/EIF2S1/AKT1/ITPR3/BID/FASLG/APAF1/PIK3CD/PRF1/CSF2RB/DDIT3/CAPN2/NFKB1/HTRA2/CYCS/LMNB1/TNFSF10/BAX/CTSD/MAPK8/ITPR1/BCL2L11/GADD45A/CTSK/PIK3R3/TNFRSF1A/ITPR2/TUBA1A/MAP3K14/RIPK1/CTSH/LMNA/TUBA3C/ERN1/NFKBIA/PARP1/GADD45G/BCL2A1/FADD/TRAF1/CASP10/GZMB/NTRK1/CASP6/IKBKG/MAPK1/BCL2L1/TRADD	68
KEGG	hsa04659	Th17 cell differentiation	55/3489	108/8135	0.05524	0.1634	0.1179	GATA3/HLA-DMA/RORA/CD4/IL27RA/TGFBR2/HLA-DMB/MAPK13/TGFB1/RORC/RARA/IL1RAP/MAPK12/NFATC1/IL2RG/TGFBR1/CD3E/STAT5A/FOS/PPP3CC/RXRB/IL6ST/CD247/HLA-DRB1/HLA-DPA1/NFKB1/IL21R/MTOR/MAPK11/CD3D/LCK/TBX21/MAPK8/HLA-DOA/NFKBIE/SMAD3/HLA-DRA/CD3G/IL6R/FOXP3/PLCG1/NFATC3/NFKBIA/ZAP70/IL2RA/MAPK14/IL22/STAT5B/TYK2/IKBKG/RUNX1/MAPK1/IL23A/NFATC2/JAK1	55
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	10/3489	15/8135	0.05529	0.1634	0.1179	HEXB/GLB1/ST3GAL2/HEXA/ST3GAL1/ST6GALNAC3/ST3GAL5/ST6GALNAC6/B4GALNT1/ST6GALNAC4	10
KEGG	hsa04672	Intestinal immune network for IgA production	27/3489	49/8135	0.05686	0.1666	0.1202	HLA-DMA/TNFSF13/CCL28/HLA-DMB/CD86/TGFB1/TNFSF13B/IL10/IL15/TNFRSF17/ITGA4/CXCR4/CD40/PIGR/HLA-DRB1/CCR10/HLA-DPA1/CXCL12/CD40LG/HLA-DOA/HLA-DRA/MAP3K14/CD28/IL5/TNFRSF13B/ICOS/AICDA	27
KEGG	hsa05152	Tuberculosis	88/3489	180/8135	0.05882	0.1708	0.1233	CALML5/HLA-DMA/CALML3/TLR4/CALM3/FCGR2B/ATP6V0A4/FCER1G/IL18/CEBPG/FCGR2C/FCGR2A/ITGAM/CD14/HLA-DMB/IL10RA/ITGB2/MAPK13/CTSS/CASP9/TGFB1/TCIRG1/PLA2R1/RFX5/TGFB3/AKT3/RAB5C/MAPK12/IL10/TLR1/CD74/MRC2/RAB5A/RAF1/CLEC4E/CASP3/SPHK2/LSP1/TLR6/PPP3CC/CORO1A/MALT1/FCGR1A/RHOA/TLR2/AKT1/NOD2/ITGAX/BID/CAMK2A/RAB5B/HLA-DRB1/APAF1/HSPA9/BCL10/HLA-DPA1/NFKB1/IL10RB/CYCS/ATP6AP1/SYK/MAPK11/CR1/BAX/CTSD/TGFB2/IFNA1/MAPK8/HLA-DOA/ATP6V0A2/RIPK2/HLA-DRA/EP300/LBP/TNFRSF1A/RFXAP/ATP6V0B/LAMP2/FADD/CALM2/SPHK1/VDR/MAPK14/CASP10/MAPK1/IL23A/JAK1/TRADD	88
KEGG	hsa04664	Fc epsilon RI signaling pathway	36/3489	68/8135	0.06015	0.1732	0.125	FYN/VAV3/FCER1G/VAV1/MAP2K4/BTK/FCER1A/MAPK13/PLA2G4F/GRB2/ALOX5AP/HRAS/LCP2/PLA2G4C/AKT3/MAPK12/RAC2/RAF1/INPP5D/MAP2K1/ALOX5/AKT1/PLA2G4D/PIK3CD/LYN/SYK/MAPK11/GAB2/MAPK8/PIK3R3/PRKCA/PLCG1/IL5/MAPK14/MAPK1/CSF2	36
KEGG	hsa04216	Ferroptosis	23/3489	41/8135	0.06068	0.1732	0.125	ACSL5/FTH1/CYBB/FTL/SAT2/SLC40A1/ACSL3/MAP1LC3C/GPX4/ACSL4/SLC7A11/GCLC/SLC39A8/ALOX15/SLC11A2/ATG5/ACSL6/STEAP3/PCBP1/ATG7/ACSL1/CP/HMOX1	23
KEGG	hsa04110	Cell cycle	63/3489	126/8135	0.06294	0.177	0.1278	SFN/MCM4/CDK7/CCNE2/SKP2/TGFB1/BUB1B/MYC/TGFB3/PTTG1/YWHAZ/ABL1/CDKN2B/TTK/CUL1/WEE1/CDC20/E2F3/CDC27/CCNB1/CCNE1/DBF4/CDC45/TFDP1/GSK3B/MAD2L1/PCNA/RBX1/PRKDC/MCM2/CDK1/MAD2L2/ESPL1/CHEK1/CCNB2/TGFB2/YWHAE/CCNA2/SKP1/STAG1/CDK4/CDC26/CDC7/SMAD3/GADD45A/EP300/CCND2/ANAPC10/MDM2/MCM6/RB1/CDKN2A/ANAPC7/HDAC1/GADD45G/SMC3/CDC6/CDKN1A/CDKN1C/HDAC2/PLK1/TFDP2/CDK6	63
KEGG	hsa04130	SNARE interactions in vesicular transport	19/3489	33/8135	0.0635	0.177	0.1278	STX19/STX2/VAMP1/VAMP5/STX5/STX1A/SEC22B/STX17/SNAP23/STX4/GOSR2/STX8/BET1L/VTI1B/STX7/VTI1A/BET1/VAMP4/STX18	19
KEGG	hsa00410	beta-Alanine metabolism	18/3489	31/8135	0.0639	0.177	0.1278	ALDH3B2/ALDH3A1/ALDH7A1/ALDH3B1/ALDH3A2/ABAT/HIBCH/ALDH1B1/ACOX3/ACADS/ACOX1/ALDH2/MLYCD/ALDH9A1/CNDP2/GAD2/DPYD/AOC2	18
KEGG	hsa04392	Hippo signaling pathway - multiple species	17/3489	29/8135	0.06413	0.177	0.1278	WWC1/RASSF4/DCHS1/TEAD3/RASSF2/TEAD4/YAP1/RASSF6/LIMD1/FRMD6/TEAD1/WTIP/RASSF1/CSNK1E/LATS1/PAK1/NF2	17
KEGG	hsa00480	Glutathione metabolism	31/3489	58/8135	0.06777	0.1854	0.1338	GGT6/GSTO2/GPX2/GGCT/GSTA3/GPX1/GPX7/GGT5/GPX8/LANCL1/GSTA4/TXNDC12/MGST2/GPX4/GSTO1/SMS/GSTP1/GSR/GCLC/RRM1/IDH2/MGST3/GSTT2/GPX3/GSTT1/IDH1/SRM/HPGDS/RRM2/GSTM5/RRM2B	31
KEGG	hsa04390	Hippo signaling pathway	77/3489	157/8135	0.06827	0.1854	0.1338	CDH1/WWC1/WNT16/BMP7/DLG3/WNT3/TGFBR2/FZD6/ITGB2/LLGL2/PPP2R2C/FZD2/TGFB1/DLG2/WNT4/TEAD3/PRKCZ/MYC/TGFB3/DLG5/SERPINE1/YWHAZ/SOX2/FZD3/BMP2/TGFBR1/PRKCI/PARD3/TEAD4/PPP2CA/YAP1/RASSF6/MPP5/AREG/DLG4/NKD2/GSK3B/DLG1/WNT5B/FZD4/LIMD1/WNT5A/WNT2B/TP73/FRMD6/PPP2R2B/PPP1CB/TGFB2/YWHAE/PARD6B/WNT10A/BMP5/TEAD1/WTIP/SMAD3/WNT7B/SMAD1/CCND2/CSNK1D/BMPR1B/RASSF1/SMAD7/PARD6A/CSNK1E/PPP2R2A/WNT7A/LATS1/BMP8A/ID2/FZD1/BMPR2/WNT1/TCF7L2/TCF7L1/FZD8/NF2/SNAI2	77
KEGG	hsa05171	Coronavirus disease - COVID-19	111/3489	232/8135	0.0698	0.188	0.1357	TLR4/C1QA/TMPRSS2/FCGR2A/C1QB/C3AR1/TLR7/C2/NRP1/C1QC/RPLP1/CYBB/MAPK13/RPL36/SELP/ACE/TLR8/RPLP0/C5AR1/IFNAR2/RPL35A/RPS19/RPL13/MAPK12/RPS7/IFNAR1/RPL36A/F13A1/RPL35/C1S/ACE2/MMP3/RPL11/FOS/MAP3K7/RPS27L/VWF/RPL10/RPL7A/RPL14/TLR2/RPL10A/RPL27A/IL6ST/RPS18/RPL23/C1R/RPS13/PIK3CD/RPL4/RPS10/CFB/RPS29/RPS17/RPS8/NFKB1/NLRP3/RPS6/RPS3/SYK/MAPK11/RPL29/RPL5/C9/RPL18/IFNA1/MAPK8/RPS15/RPL7/RPL22/CFD/EGFR/IFIH1/RPSA/PIK3R3/RPS16/TNFRSF1A/PRKCA/RPS21/MASP2/RPL22L1/RPS2/RPL6/IL6R/RPS5/RPL3/RPL12/PLCG1/IRF3/NFKBIA/PRKCB/RPS28/FAU/C5/AGTR1/MAPK14/RSL24D1/RPL38/RPL37/TYK2/FGB/IKBKG/MAPK1/TLR3/C6/RPL27/CSF2/JAK1/RPS9/TRAF3/RPL31	111
KEGG	hsa00562	Inositol phosphate metabolism	38/3489	73/8135	0.07128	0.1905	0.1375	PIK3C2G/IPPK/IMPA2/INPP4A/MTMR1/PIP4K2C/PLCB2/INPP5B/PIK3C2B/PIK3CG/INPP1/PIP4K2A/INPP5D/PIP5K1C/INPPL1/ITPKC/PI4KA/MTMR4/SYNJ1/PIK3CD/MTMR2/MTMR14/ITPKB/INPP5J/PIP5KL1/ISYNA1/PIP5K1A/MTMR6/CDIPT/FIG4/INPP4B/ITPK1/PLCZ1/PI4KB/MINPP1/PLCG1/IMPA1/PTEN	38
KEGG	hsa05226	Gastric cancer	73/3489	149/8135	0.07595	0.1987	0.1434	CDH1/JUP/WNT16/CSNK1A1/WNT3/TGFBR2/FZD6/CCNE2/HGF/FGFR2/FZD2/GRB2/TGFB1/BRAF/WNT4/MYC/FGF18/TGFB3/HRAS/AKT3/FZD3/CDKN2B/RAF1/TGFBR1/E2F3/MAP2K1/CCNE1/GSK3B/RXRB/AKT1/WNT5B/SHC3/FZD4/FGF10/WNT5A/WNT2B/PIK3CD/EGF/SHC1/SHC4/MTOR/POLK/BAX/TGFB2/FRAT1/WNT10A/GAB1/EGFR/SMAD3/RPS6KB2/GADD45A/WNT7B/PIK3R3/RB1/WNT7A/TERT/RPS6KB1/MLH1/FZD1/DDB2/GADD45G/MUC2/LRP5/CDKN1A/WNT1/FGF17/TCF7L2/LRP6/MAPK1/TCF7L1/FZD8/FGF6/ARAF	73
KEGG	hsa00280	Valine, leucine and isoleucine degradation	26/3489	48/8135	0.07599	0.1987	0.1434	BCAT1/HMGCS1/ACAT2/HMGCS2/ALDH7A1/ACAD8/IVD/HMGCL/ALDH3A2/AACS/ABAT/HIBCH/OXCT1/ACAA2/ACADSB/MCCC2/ALDH1B1/ACADS/HIBADH/MCCC1/PCCA/ALDH2/HSD17B10/ALDH9A1/MCEE/DLD	26
KEGG	hsa04668	TNF signaling pathway	56/3489	112/8135	0.07614	0.1987	0.1434	CSF1/VEGFC/MAP2K4/CREB3L2/MAPK13/TNFRSF1B/CREB3/CCL5/CREB5/TAB3/AKT3/VCAM1/MAPK12/MMP3/MLKL/CASP3/IL15/MAP2K1/FOS/TRAF5/MAP3K7/AKT1/NOD2/JAG1/CREB3L1/PIK3CD/MMP14/NFKB1/MAPK11/ITCH/MAPK8/MMP9/PIK3R3/TNFRSF1A/MAP3K14/RIPK1/JUNB/CXCL5/ICAM1/ATF6B/NFKBIA/FADD/TRAF1/CREB3L4/MAPK14/IL18R1/CASP10/RIPK3/EDN1/IKBKG/MAPK1/BCL3/CSF2/SELE/TRAF3/TRADD	56
KEGG	hsa04150	mTOR signaling pathway	76/3489	156/8135	0.08063	0.2061	0.1487	ATP6V1C2/WNT16/PRR5L/WNT3/LPIN2/FZD6/RPS6KA2/SKP2/FZD2/GRB2/CLIP1/BRAF/WNT4/HRAS/AKT3/SEH1L/IGF1/FZD3/RAF1/SLC7A5/RPS6KA6/MAP2K1/LPIN1/MIOS/GSK3B/RHOA/AKT1/WNT5B/TBC1D7/FZD4/WNT5A/WNT2B/PIK3CD/GRB10/SGK1/STRADA/RPS6/MTOR/STRADB/WDR59/ATP6V1C1/NPRL3/ATP6V1G1/WNT10A/EIF4E/EIF4EBP1/FLCN/FNIP1/RPS6KB2/WNT7B/SEC13/ATP6V1B1/PIK3R3/TNFRSF1A/PRKCA/RRAGC/WNT7A/STK11/RNF152/PRKAA1/RPS6KB1/MAPKAP1/FNIP2/FZD1/PRKCB/RRAGB/LRP5/WNT1/ATP6V1G2/ATP6V1A/LRP6/MAPK1/WDR24/FZD8/PRR5/PTEN	76
KEGG	hsa04218	Cellular senescence	76/3489	156/8135	0.08063	0.2061	0.1487	CALML5/CALML3/CALM3/TGFBR2/CCNE2/RRAS/SLC25A5/ETS1/MAPK13/TGFB1/MYC/TGFB3/HRAS/AKT3/SERPINE1/MAPK12/SQSTM1/CDKN2B/NFATC1/RAF1/TGFBR1/E2F3/MAP2K1/CCNB1/CCNE1/PPP3CC/HLA-C/AKT1/NFATC4/ITPR3/PIK3CD/CACNA1D/FOXO1/CDK1/MRAS/CAPN2/NFKB1/MTOR/CHEK1/MAPK11/CCNB2/PPP1CB/TGFB2/HLA-F/CCNA2/CDK4/VDAC1/ITPR1/EIF4EBP1/SMAD3/GADD45A/HLA-B/CCND2/PIK3R3/LIN37/NBN/ITPR2/MDM2/RB1/HLA-G/HLA-A/CDKN2A/NFATC3/GADD45G/CALM2/RAD1/FOXM1/CDKN1A/MAPK14/LIN54/KIR2DL4/MAPK1/RAD50/NFATC2/CDK6/PTEN	76
KEGG	hsa04022	cGMP-PKG signaling pathway	81/3489	167/8135	0.08084	0.2061	0.1487	CALML5/CALML3/ATP1B1/CALM3/ADORA3/GNA12/GNAI1/GNAI2/CREB3L2/SLC25A5/MEF2C/PIK3R5/FXYD2/PLCB2/CREB3/GNAI3/KCNJ8/ATP1B3/CREB5/AKT3/PIK3CG/KCNMA1/ATP1A1/VASP/GTF2IRD1/KCNMB1/NFATC1/RAF1/GNAQ/SLC8A1/PIK3R6/MAP2K1/ADCY4/ADCY1/PPP3CC/PDE2A/RHOA/MYL9/AKT1/NFATC4/ITPR3/NPR1/CREB3L1/CNGA1/ADCY2/KCNMB3/ATP2A3/MEF2A/CACNA1D/PPIF/PPP1CB/ROCK1/PRKG1/VDAC1/ITPR1/ADCY8/SRF/ITPR2/PDE5A/ADCY9/ADRB1/PRKG2/ATP2B1/ADORA1/ADCY6/MYLK4/MEF2D/ATF6B/ROCK2/NFATC3/MYH7/CALM2/CREB3L4/AGTR1/ATP1B2/IRS2/MAPK1/SLC8A2/NPPA/NFATC2/BDKRB2	81
KEGG	hsa05142	Chagas disease	51/3489	102/8135	0.08744	0.2212	0.1597	TLR4/C1QA/GNAI1/C1QB/TGFBR2/GNAI2/C1QC/MAP2K4/MAPK13/ACE/PPP2R2C/TGFB1/PLCB2/GNAI3/TGFB3/CCL5/AKT3/SERPINE1/MAPK12/IL10/GNAQ/TGFBR1/CD3E/FOS/PPP2CA/ADCY1/TLR6/TLR2/AKT1/GNAS/FASLG/CD247/PIK3CD/NFKB1/PPP2R2B/MAPK11/TGFB2/CD3D/MAPK8/CD3G/PIK3R3/TNFRSF1A/PPP2R2A/GNA15/NFKBIA/FADD/MAPK14/IKBKG/MAPK1/GNA14/BDKRB2	51
KEGG	hsa04725	Cholinergic synapse	56/3489	113/8135	0.08948	0.2247	0.1622	FYN/GNAI1/GNAI2/GNG10/CREB3L2/PRKACB/KCNQ1/PIK3R5/GNG2/GNB3/PLCB2/CREB3/GNAI3/HRAS/CREB5/AKT3/PIK3CG/GNAQ/PIK3R6/GNG11/MAP2K1/FOS/ADCY4/ADCY1/KCNJ14/KCNJ12/AKT1/GNB4/KCNJ6/ITPR3/GNG7/CREB3L1/ADCY2/CAMK2A/PRKACA/PIK3CD/CACNA1D/CHRNA3/GNB1/KCNJ2/GNGT2/ITPR1/ADCY8/GNG5/PIK3R3/PRKCA/ITPR2/ADCY9/ADCY6/CHRM3/CHRM1/PRKCB/CREB3L4/CHRNA6/CACNA1A/MAPK1	56
KEGG	hsa00650	Butanoate metabolism	16/3489	28/8135	0.09152	0.2258	0.163	HMGCS1/ACAT2/ACSM1/BDH1/L2HGDH/HMGCS2/ALDH5A1/HMGCL/AACS/ABAT/BDH2/OXCT1/ACSM3/ACSM5/ACADS/GAD2	16
KEGG	hsa00430	Taurine and hypotaurine metabolism	10/3489	16/8135	0.09181	0.2258	0.163	GGT6/GGT5/CDO1/FMO5/ADO/FMO3/FMO1/FMO2/FMO4/GAD2	10
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	49/3489	98/8135	0.09248	0.2258	0.163	F2RL1/ALOX12/CALML5/CALML3/CALM3/PTGER2/TRPV2/HTR2A/CYP2J2/PRKACB/MAPK13/PLA2G4F/P2RY2/PLCB2/PTGER4/PLA2G4C/IL1RAP/IGF1/MAPK12/GNAQ/ADCY4/ADCY1/ITPR3/GNAS/PLA2G4D/ADCY2/CAMK2A/HRH1/PRKACA/PIK3CD/MAPK11/PPP1CB/MAPK8/TRPM8/ITPR1/ADCY8/PIK3R3/PRKCA/ITPR2/ADCY9/TRPV3/ADCY6/PRKCH/PLCG1/PRKCB/CALM2/MAPK14/NTRK1/BDKRB2	49
KEGG	hsa00061	Fatty acid biosynthesis	11/3489	18/8135	0.09318	0.2258	0.163	ACSBG1/ACSL5/HSD17B8/ACSL3/ACACA/ACSL4/MECR/ACSBG2/ACSL6/FASN/ACSL1	11
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	14/3489	24/8135	0.09331	0.2258	0.163	EXTL2/EXT2/B4GALT7/NDST1/HS3ST2/HS6ST2/XYLT1/B3GAT3/EXTL1/HS6ST1/EXT1/HS3ST1/HS2ST1/GLCE	14
KEGG	hsa04066	HIF-1 signaling pathway	54/3489	109/8135	0.09461	0.2273	0.1641	TLR4/SLC2A1/MKNK1/CYBB/TIMP1/ENO2/EGLN3/HK3/AKT3/SERPINE1/IGF1/PDK1/ANGPT2/MAP2K1/ARNT/CUL2/FLT1/TEK/AKT1/CAMK2A/RBX1/PIK3CD/EGF/NFKB1/LDHB/RPS6/MTOR/EPO/VHL/LDHAL6B/EGFR/EIF4E/EIF4EBP1/RPS6KB2/EP300/PFKP/ALDOC/PIK3R3/PRKCA/IL6R/EGLN1/RPS6KB1/PLCG1/ENO3/PRKCB/CDKN1A/EDN1/PDHB/MAPK1/HK1/ANGPT1/HMOX1/NPPA/LDHA	54
KEGG	hsa05202	Transcriptional misregulation in cancer	92/3489	193/8135	0.09984	0.2351	0.1697	JUP/BCL11B/WNT16/PROM1/CSF1R/SIX4/HPGD/TMPRSS2/HOXA11/SIX1/TGFBR2/SPINT1/ITGAM/LYL1/CD14/LMO2/CD86/MEF2C/HHEX/NFKBIZ/ETV7/SPI1/MYC/RARA/FLI1/IGF1/HOXA10/ERG/KLF3/MMP3/REL/ELK4/MEIS1/FCGR1A/CD40/ETV5/FLT1/RXRB/ZEB1/FUT8/PLAU/SS18/LDB1/DUSP6/SS18L1/TSPAN7/FOXO1/CDK14/IL1R2/DDIT3/NCOR1/TFE3/SIN3A/NFKB1/PBX3/POLK/BAX/TAF15/RUNX2/CCNA2/MMP9/PAX3/PDGFA/GADD45A/SMAD1/CCND2/CEBPA/MDM2/RUNX1T1/NR4A3/HDAC1/ID2/PBX1/DDB2/WT1/GADD45G/MAX/BCL2A1/TRAF1/SUPT3H/CDKN1A/FUS/GZMB/NTRK1/AFF1/HDAC2/RUNX1/PAX5/CDK9/PPARG/BCL2L1/CSF2	92
KEGG	hsa00620	Pyruvate metabolism	25/3489	47/8135	0.1002	0.2351	0.1697	ACAT2/GLO1/ME3/ALDH7A1/ACACA/ALDH3A2/AKR1A1/ME2/ADH6/DLAT/ADH7/LDHB/FH/ADH1C/ALDH1B1/LDHAL6B/ALDH2/ADH1B/ALDH9A1/PCK2/MDH2/PDHB/HAGH/DLD/LDHA	25
KEGG	hsa03420	Nucleotide excision repair	25/3489	47/8135	0.1002	0.2351	0.1697	CDK7/RAD23B/RFC2/RFC5/POLE2/POLD4/GTF2H3/POLE3/GTF2H1/PCNA/RBX1/CUL4A/GTF2H2/ERCC6/LIG1/DDB1/RPA1/ERCC1/GTF2H4/DDB2/POLD3/RFC1/ERCC8/RFC3/ERCC5	25
KEGG	hsa04658	Th1 and Th2 cell differentiation	46/3489	92/8135	0.1007	0.2351	0.1697	GATA3/HLA-DMA/CD4/DLL1/HLA-DMB/MAPK13/RBPJ/STAT4/NOTCH2/MAPK12/IL12RB2/NFATC1/IL2RG/CD3E/STAT5A/FOS/PPP3CC/JAG1/CD247/HLA-DRB1/HLA-DPA1/NFKB1/MAPK11/CD3D/LCK/TBX21/MAPK8/HLA-DOA/NFKBIE/HLA-DRA/CD3G/PLCG1/NFATC3/NFKBIA/ZAP70/IL2RA/IL5/MAPK14/STAT5B/TYK2/MAML2/JAG2/IKBKG/MAPK1/NFATC2/JAK1	46
KEGG	hsa04270	Vascular smooth muscle contraction	65/3489	134/8135	0.1083	0.2513	0.1813	PLA2G3/CALML5/CALML3/CALM3/GNA12/RAMP2/PRKACB/ARHGEF11/RAMP3/PLA2G4F/BRAF/PLCB2/CALCRL/PLA2G4C/KCNMA1/PLA2G2A/KCNMB1/RAF1/GNAQ/MAP2K1/ADCY4/ADCY1/MYH14/RHOA/MYL9/ITPR3/NPR1/AGT/GNAS/ADORA2B/PLA2G4D/ADCY2/KCNMB3/EDN3/PRKACA/CACNA1D/PLA2G2F/PLA2G2D/CALD1/PPP1CB/ROCK1/PRKG1/ITPR1/PLA2G12A/ADCY8/PRKCA/PLA2G1B/ITPR2/PTGIR/ADCY9/RAMP1/ADCY6/MYLK4/ROCK2/MYH9/PRKCH/PRKCB/CALM2/ACTG2/AGTR1/EDN1/MAPK1/MYH10/NPPA/ARAF	65
KEGG	hsa01524	Platinum drug resistance	37/3489	73/8135	0.1091	0.2514	0.1814	GSTO2/GSTA3/GSTA4/CASP9/ATP7A/AKT3/PMAIP1/MSH2/TOP2A/CASP3/MGST2/MSH3/AKT1/GSTO1/TOP2B/BID/GSTP1/FASLG/APAF1/PIK3CD/SLC31A1/CYCS/BAX/MGST3/GSTT2/PIK3R3/MDM2/GSTT1/ERCC1/CDKN2A/MLH1/FADD/CDKN1A/MAPK1/GSTM5/BRCA1/BCL2L1	37
KEGG	hsa04340	Hedgehog signaling pathway	29/3489	56/8135	0.1127	0.2578	0.1861	CSNK1A1/ARRB1/PRKACB/ARRB2/KIF7/HHIP/CUL1/SCUBE2/GSK3B/DISP1/PRKACA/MGRN1/MEGF8/EVC/CCND2/CSNK1D/SMURF2/CSNK1E/SPOPL/KIF3A/HHAT/SPOP/CUL3/EVC2/SUFU/BOC/CSNK1G1/IQCE/GPR161	29
KEGG	hsa04910	Insulin signaling pathway	66/3489	137/8135	0.1205	0.2714	0.1959	CALML5/CALML3/CALM3/FLOT1/MKNK1/G6PC3/PRKACB/RAPGEF1/GRB2/BRAF/PRKCZ/FBP1/HRAS/CBLB/HK3/AKT3/PTPRF/RHOQ/PHKA1/RAF1/ACACA/PRKCI/MAP2K1/PRKAG2/INPPL1/GSK3B/GCK/AKT1/SHC3/PHKB/PRKACA/PIK3CD/CBL/FOXO1/SHC1/SHC4/RPS6/MTOR/PPP1R3D/PYGM/PPP1CB/PTPN1/SOCS2/MAPK8/PRKAR2A/EIF4E/EIF4EBP1/RPS6KB2/PPARGC1A/PIK3R3/FLOT2/PRKAA1/RPS6KB1/CALM2/PHKG1/IRS2/FASN/PCK2/MAPK1/HK1/EXOC7/PYGL/PPP1R3C/PPP1R3F/TRIP10/ARAF	66
KEGG	hsa04726	Serotonergic synapse	56/3489	115/8135	0.1208	0.2714	0.1959	ALOX12B/ALOX12/CYP2C18/GNAI1/PTGS1/GNAI2/HTR2A/GNG10/CYP2J2/PRKACB/GABRB2/PLA2G4F/GNG2/BRAF/GNB3/PLCB2/GNAI3/HRAS/PLA2G4C/ALOX15B/RAF1/GNAQ/RAPGEF3/CASP3/GNG11/MAP2K1/CYP2C9/ALOX5/HTR3A/GNB4/KCNJ6/ITPR3/GNG7/GNAS/PLA2G4D/PRKACA/CACNA1D/TRPC1/DUSP1/ALOX15/GNB1/GABRB1/GNGT2/ITPR1/GNG5/SLC18A2/PRKCA/KCNJ5/ITPR2/SLC6A4/HTR7/PRKCB/HTR1A/CACNA1A/MAPK1/ARAF	56
KEGG	hsa05032	Morphine addiction	45/3489	91/8135	0.1222	0.2714	0.1959	GNAI1/GABRP/GNAI2/ARRB1/GNG10/PDE1A/PRKACB/ARRB2/GABRB2/GNG2/GNB3/GNAI3/PDE1C/GNG11/ADCY4/ADCY1/GABRR2/PDE2A/GNB4/KCNJ6/GNG7/PDE7B/GNAS/ADCY2/PRKACA/GABRQ/GNB1/GABRB1/PDE4A/GNGT2/ADCY8/GNG5/PRKCA/GABBR1/KCNJ5/ADCY9/GABBR2/GABRE/ADORA1/ADCY6/PRKCB/PDE7A/CACNA1A/GABRR1/SLC32A1	45
KEGG	hsa00052	Galactose metabolism	17/3489	31/8135	0.1224	0.2714	0.1959	GALM/PGM2/AKR1B1/G6PC3/GLB1/GAA/AKR1B10/HK3/UGP2/LCT/GCK/GLA/PFKP/MGAM/PGM1/HK1/GALK1	17
KEGG	hsa04927	Cortisol synthesis and secretion	33/3489	65/8135	0.1227	0.2714	0.1959	NCEH1/CREB3L2/PRKACB/LDLR/PLCB2/CREB3/CYP11A1/STAR/CREB5/GNAQ/KCNK2/ADCY4/ADCY1/ITPR3/CREB3L1/AGT/GNAS/ADCY2/PRKACA/CACNA1D/CYP21A2/SCARB1/ITPR1/ADCY8/ITPR2/ADCY9/KCNK3/ADCY6/ATF6B/PBX1/CREB3L4/AGTR1/NR4A1	33
KEGG	hsa00561	Glycerolipid metabolism	31/3489	61/8135	0.1302	0.2862	0.2065	PNLIPRP3/MBOAT2/LPIN2/PNPLA3/AGPAT4/AKR1B1/MBOAT1/AGPAT1/AKR1B10/ALDH7A1/DGAT2/ALDH3A2/AKR1A1/DGKA/LPIN1/DGKD/GLA/DGKI/LCLAT1/ALDH1B1/GPAT2/DGKZ/MGLL/GK2/ALDH2/GLYCTK/ALDH9A1/DGAT1/LIPG/AGPAT2/DGKG	31
KEGG	hsa05223	Non-small cell lung cancer	36/3489	72/8135	0.1348	0.2942	0.2123	HGF/GRB2/CASP9/BRAF/TGFA/HRAS/AKT3/RAF1/E2F3/MAP2K1/STAT5A/EML4/RXRB/AKT1/PIK3CD/EGF/POLK/BAX/CDK4/EGFR/GADD45A/RET/PIK3R3/RASSF1/PRKCA/RB1/CDKN2A/PLCG1/DDB2/GADD45G/PRKCB/CDKN1A/STAT5B/MAPK1/CDK6/ARAF	36
KEGG	hsa00770	Pantothenate and CoA biosynthesis	12/3489	21/8135	0.1358	0.2945	0.2125	BCAT1/PANK1/PANK3/ALDH3A2/VNN2/ENPP1/PPCDC/AASDHPPT/ALDH1B1/ALDH2/PANK2/DPYD	12
KEGG	hsa05330	Allograft rejection	20/3489	38/8135	0.1465	0.3157	0.2278	HLA-DMA/HLA-DMB/CD86/IL10/HLA-C/CD40/FASLG/HLA-DRB1/PRF1/HLA-DPA1/CD40LG/HLA-F/HLA-DOA/HLA-DRA/HLA-B/HLA-G/HLA-A/CD28/IL5/GZMB	20
KEGG	hsa00270	Cysteine and methionine metabolism	26/3489	51/8135	0.1517	0.3248	0.2344	BCAT1/PSAT1/DNMT3A/DNMT3B/GOT2/PHGDH/CBS/SDS/GOT1/SDSL/CDO1/AMD1/SMS/GCLC/LDHB/LDHAL6B/MTR/MAT1A/AHCYL2/ADI1/ENOPH1/SRM/BHMT2/MDH2/AHCY/LDHA	26
KEGG	hsa04935	Growth hormone synthesis, secretion and action	57/3489	119/8135	0.1541	0.3278	0.2366	GNAI1/GNAI2/MAP2K4/CREB3L2/PRKACB/MAPK13/GRB2/PLCB2/CREB3/GNAI3/HRAS/CREB5/AKT3/IGF1/MAPK12/RAF1/GNAQ/MAP2K1/STAT5A/FOS/ADCY4/ADCY1/GSK3B/AKT1/ITPR3/SHC3/CREB3L1/GNAS/ADCY2/PRKACA/PIK3CD/CACNA1D/SHC1/SHC4/MTOR/MAPK11/SOCS2/MAPK8/ITPR1/EP300/ADCY8/PIK3R3/PRKCA/GH1/ITPR2/ADCY9/JUNB/ADCY6/ATF6B/PLCG1/PRKCB/MAP3K1/CREB3L4/MAPK14/IRS2/STAT5B/MAPK1	57
KEGG	hsa04713	Circadian entrainment	47/3489	97/8135	0.1561	0.3299	0.2381	CALML5/CALML3/CALM3/GNAI1/GNAI2/GNG10/PRKACB/GNG2/GNB3/PLCB2/GNAI3/GNAQ/GNG11/FOS/ADCY4/ADCY1/GNB4/KCNJ6/ITPR3/GNG7/GNAS/ADCY2/CAMK2A/PRKACA/CACNA1D/NOS1AP/GNB1/NOS1/PRKG1/GNGT2/ITPR1/RYR1/ADCY8/GNG5/MTNR1A/GRIN2D/PRKCA/KCNJ5/ADCY9/PRKG2/ADCY6/ADCYAP1/RYR3/PRKCB/CALM2/MAPK1/GRIA2	47
KEGG	hsa04020	Calcium signaling pathway	111/3489	240/8135	0.1582	0.3324	0.2399	FGFR3/CALML5/CALML3/CALM3/ERBB3/MST1R/TPCN1/ORAI3/TBXA2R/P2RX4/VEGFC/HTR2A/CYSLTR1/PDE1A/SLC25A5/PRKACB/HGF/FGFR2/STIM2/PDGFD/CAMK1/PLCB2/P2RX5/FGF18/PDGFB/PHKA1/PDE1C/GNAQ/PDGFRA/F2R/SLC8A1/HRC/CD38/SPHK2/ASPH/ADCY4/PDGFRB/ADCY1/PPP3CC/CXCR4/VEGFB/ITPKC/FLT4/PDGFC/FLT1/ITPR3/ORAI2/MCOLN1/OXTR/GNAS/ADORA2B/FGF10/ADCY2/PHKB/ATP2A3/CAMK2A/HRH1/PRKACA/CACNA1D/EGF/FGFR1/KDR/PPIF/P2RX7/ITPKB/PTGFR/NOS1/MST1/EGFR/VDAC1/ITPR1/PDGFA/RET/RYR1/ADCY8/GRIN2D/PRKCA/ITPR2/ADCY9/ADRB1/TNNC1/PLCZ1/ATP2B1/HTR7/GNA15/TPCN2/MYLK4/LHCGR/RYR3/CHRM3/PTAFR/CHRM1/PLCG1/ERBB4/PRKCB/CALM2/LTB4R2/SPHK1/AGTR1/PHKG1/TACR1/NTRK1/PTK2B/TRDN/FGF17/CACNA1A/GNA14/PTGER1/SLC8A2/FGF6/BDKRB2	111
KEGG	hsa04730	Long-term depression	30/3489	60/8135	0.162	0.3381	0.244	GNA12/GNAI1/GNAI2/PLA2G4F/BRAF/PLCB2/GNAI3/HRAS/PLA2G4C/IGF1/RAF1/GNAQ/MAP2K1/PPP2CA/ITPR3/GNAS/PLA2G4D/LYN/NOS1/PRKG1/ITPR1/RYR1/PRKCA/ITPR2/PRKG2/PRKCB/CACNA1A/MAPK1/ARAF/GRIA2	30
KEGG	hsa04625	C-type lectin receptor signaling pathway	50/3489	104/8135	0.1644	0.341	0.2461	CALML5/CALML3/EGR3/CALM3/FCER1G/RRAS/MAPK13/HRAS/CBLB/AKT3/MAPK12/IL10/NFATC1/RAF1/CCL22/CLEC4E/LSP1/PPP3CC/MALT1/RHOA/AKT1/NFATC4/ITPR3/CLEC1B/PIK3CD/BCL10/MRAS/NFKB1/NLRP3/SYK/MAPK11/PYCARD/MAPK8/CLEC4D/IL17D/ITPR1/PIK3R3/ITPR2/MAP3K14/MDM2/NFATC3/NFKBIA/CALM2/MAPK14/IKBKG/MAPK1/BCL3/PAK1/IL23A/NFATC2	50
KEGG	hsa04912	GnRH signaling pathway	45/3489	93/8135	0.1654	0.341	0.2461	CALML5/CALML3/CALM3/PLD1/MAP2K4/PRKACB/MAPK13/PLA2G4F/GRB2/MAP3K3/PLCB2/HRAS/PLA2G4C/MAPK12/RAF1/GNAQ/MAP2K1/ADCY4/ADCY1/ITPR3/GNAS/PLA2G4D/ADCY2/CAMK2A/PRKACA/CACNA1D/MMP14/MAPK11/EGR1/MAPK8/MAP3K4/EGFR/MMP2/ITPR1/ADCY8/PRKCA/ITPR2/ADCY9/ADCY6/PRKCB/CALM2/MAP3K1/MAPK14/PTK2B/MAPK1	45
KEGG	hsa04923	Regulation of lipolysis in adipocytes	28/3489	56/8135	0.1726	0.3536	0.2552	GNAI1/PTGS1/GNAI2/PRKACB/ABHD5/GNAI3/AKT3/ADCY4/ADCY1/AKT1/NPR1/GNAS/ADCY2/PRKACA/PIK3CD/PRKG1/NPY1R/ADCY8/PIK3R3/MGLL/ADCY9/ADRB1/PRKG2/ADORA1/ADCY6/NPY/IRS2/NPPA	28
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14/3489	26/8135	0.1754	0.355	0.2562	PGAP1/PIGA/PIGT/PIGW/GPLD1/PIGL/PIGP/PIGH/GPAA1/PIGN/PIGF/PIGK/MPPE1/PIGC	14
KEGG	hsa00790	Folate biosynthesis	14/3489	26/8135	0.1754	0.355	0.2562	GGH/AKR1B1/CBR1/SPR/AKR1B10/PTS/FPGS/GCH1/MOCS1/ALPL/AKR1C3/PCBD2/GPHN/MOCS2	14
KEGG	hsa05219	Bladder cancer	21/3489	41/8135	0.1779	0.358	0.2584	CDH1/FGFR3/DAPK1/BRAF/MYC/HRAS/RAF1/E2F3/MAP2K1/EGF/MMP9/CDK4/EGFR/MMP2/RASSF1/MDM2/RB1/CDKN2A/CDKN1A/MAPK1/ARAF	21
KEGG	hsa00600	Sphingolipid metabolism	26/3489	52/8135	0.1841	0.3676	0.2653	ACER1/PSAPL1/SGPP2/SPTLC3/DEGS1/SMPD3/PSAP/DEGS2/HEXB/GLB1/HEXA/NEU1/UGCG/SMPD2/ARSA/SPHK2/UGT8/GLA/GALC/B4GALNT1/SGPL1/B4GALT6/SPHK1/SGPP1/NEU3/SPTLC1	26
KEGG	hsa04921	Oxytocin signaling pathway	72/3489	154/8135	0.1849	0.3676	0.2653	CALML5/CALML3/CACNA2D4/CALM3/GNAI1/GNAI2/PRKACB/MEF2C/PIK3R5/PLA2G4F/TRPM2/CAMK1/PLCB2/GNAI3/HRAS/PLA2G4C/PIK3CG/NFATC1/RAF1/GNAQ/CD38/PIK3R6/MAP2K1/FOS/ADCY4/PRKAG2/ADCY1/PPP3CC/KCNJ14/RHOA/KCNJ12/MYL9/KCNJ6/NFATC4/ITPR3/NPR1/OXTR/GNAS/PLA2G4D/ADCY2/CAMKK2/CAMK2A/CACNA2D2/CACNB1/PRKACA/CACNA1D/EEF2K/PPP1CB/ROCK1/CACNB4/KCNJ2/EGFR/ITPR1/RYR1/ADCY8/PRKCA/KCNJ5/ITPR2/ADCY9/PRKAA1/ADCY6/MYLK4/RYR3/ROCK2/NFATC3/PRKCB/CALM2/CDKN1A/CACNB2/MAPK1/NPPA/NFATC2	72
KEGG	hsa00340	Histidine metabolism	12/3489	22/8135	0.1862	0.368	0.2656	HAL/ALDH3B2/ALDH3A1/HNMT/ALDH7A1/ALDH3B1/ALDH3A2/FTCD/ALDH1B1/ALDH2/ALDH9A1/CNDP2	12
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	67/3489	143/8135	0.1889	0.3692	0.2665	FGFR3/DLX5/ISL1/WNT16/KLF4/ACVR2A/WNT3/FZD6/MAPK13/FGFR2/FZD2/GRB2/ZFHX3/WNT4/JARID2/MYC/HRAS/AKT3/ACVR1/IGF1/MAPK12/HOXA1/SOX2/FZD3/RAF1/SMARCAD1/MEIS1/MAP2K1/GSK3B/AKT1/WNT5B/LEFTY2/IL6ST/FZD4/WNT5A/WNT2B/PIK3CD/FGFR1/PCGF3/ID3/NANOG/MAPK11/WNT10A/SMAD3/WNT7B/SMAD1/RIF1/SETDB1/BMPR1B/OTX1/PIK3R3/HOXD1/LHX5/PCGF2/WNT7A/SMAD9/ID4/INHBE/ID2/FZD1/NEUROG1/BMPR2/MAPK14/WNT1/MAPK1/FZD8/JAK1	67
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	19/3489	37/8135	0.1901	0.3692	0.2665	SFN/ATP1B1/SCNN1B/SCNN1G/FXYD2/ATP1B3/ATP1A1/IGF1/PIK3CD/SGK1/SLC9A3R2/PIK3R3/PRKCA/HSD11B2/PRKCB/SCNN1A/ATP1B2/KCNJ1/MAPK1	19
KEGG	hsa05216	Thyroid cancer	19/3489	37/8135	0.1901	0.3692	0.2665	CDH1/BRAF/MYC/HRAS/CCDC6/MAP2K1/RXRB/POLK/BAX/GADD45A/RET/DDB2/GADD45G/CDKN1A/NTRK1/TCF7L2/MAPK1/PPARG/TCF7L1	19
KEGG	hsa04370	VEGF signaling pathway	29/3489	59/8135	0.199	0.3842	0.2773	MAPK13/PLA2G4F/CASP9/HRAS/PLA2G4C/AKT3/MAPK12/RAC2/RAF1/SPHK2/MAP2K1/PPP3CC/PXN/AKT1/PLA2G4D/PIK3CD/KDR/MAPK11/MAPKAPK3/HSPB1/PIK3R3/PRKCA/PLCG1/PRKCB/SPHK1/MAPK14/SH2D2A/MAPK1/NFATC2	29
KEGG	hsa04931	Insulin resistance	51/3489	108/8135	0.2063	0.3959	0.2857	GFPT2/SLC2A1/NR1H3/CREB3L2/G6PC3/RPS6KA2/SLC27A3/PRKCZ/CREB3/CREB5/AKT3/PTPRF/RPS6KA6/PRKAG2/SLC27A1/GSK3B/TBC1D4/AKT1/CREB3L1/AGT/PIK3CD/FOXO1/SLC27A6/NFKB1/MTOR/PPP1R3D/PYGM/PPP1CB/PTPN1/MLXIP/MAPK8/RPS6KB2/PPARGC1A/PIK3R3/TNFRSF1A/SLC27A4/CRTC2/PRKAA1/GFPT1/NR1H2/RPS6KB1/NFKBIA/PRKCB/CREB3L4/TRIB3/IRS2/PCK2/PYGL/PPP1R3C/OGT/PTEN	51
KEGG	hsa04630	JAK-STAT signaling pathway	75/3489	162/8135	0.2101	0.3966	0.2863	IL20RB/IL22RA1/IL20RA/IL13RA2/EPOR/IL27RA/PIM1/IL10RA/GRB2/STAT4/MYC/HRAS/IFNAR2/PDGFB/AKT3/IL10/IL12RB2/IFNAR1/IL2RG/RAF1/PDGFRA/CSF3R/PTPN6/IL15/STAT5A/PDGFRB/IL3RA/AKT1/IL6ST/IL11/CSF2RA/PIK3CD/EGF/IL22RA2/CTF1/CSF2RB/IL10RB/IL21R/MTOR/EPO/FHL1/SOCS2/THPO/IFNA1/IL20/IL7R/IL17D/IL7/EGFR/SOCS6/PDGFA/EP300/CCND2/PIK3R3/GH1/IL9/IL13RA1/IL6R/IL5RA/PIAS1/IL2RA/IL5/STAM/CDKN1A/STAM2/IL22/PIAS3/STAT5B/TYK2/IL19/OSMR/IL23A/BCL2L1/CSF2/JAK1	75
KEGG	hsa05140	Leishmaniasis	37/3489	77/8135	0.2102	0.3966	0.2863	HLA-DMA/TLR4/NCF4/FCGR2C/FCGR2A/ITGAM/CYBA/HLA-DMB/CYBB/ITGB2/MAPK13/TGFB1/TGFB3/MAPK12/IL10/PTPN6/FOS/MAP3K7/ITGA4/FCGR1A/NCF2/TLR2/HLA-DRB1/HLA-DPA1/NFKB1/MAPK11/CR1/TGFB2/HLA-DOA/HLA-DRA/MARCKSL1/NFKBIA/PRKCB/MAPK14/EEF1A2/MAPK1/JAK1	37
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	37/3489	77/8135	0.2102	0.3966	0.2863	DSP/JUP/ITGA2/ITGB6/CACNA2D4/SGCD/GJA1/ITGA5/SGCB/ITGB5/SLC8A1/DSG2/ITGA4/ITGA10/ITGB3/ITGA9/ATP2A3/CACNA2D2/ITGA11/CACNB1/CACNA1D/SGCA/CACNB4/ITGA7/ITGA3/DSC2/LAMA1/LMNA/ITGA6/ITGB4/TCF7L2/CACNB2/ITGB8/DMD/SLC8A2/TCF7L1/ITGA2B	37
KEGG	hsa04064	NF-kappa B signaling pathway	49/3489	104/8135	0.2182	0.4093	0.2954	TLR4/LY96/CARD14/CD14/BTK/CSNK2A2/TNFSF11/CCL21/TAB3/VCAM1/TNFSF13B/TRAF5/MAP3K7/MALT1/CD40/PLAU/TRIM25/BCL10/LTB/LYN/NFKB1/CXCL12/CD40LG/SYK/EDAR/CCL19/LCK/CCL4/GADD45A/LBP/TNFRSF1A/MAP3K14/RIPK1/ICAM1/PLCG1/NFKBIA/PARP1/CSNK2A1/GADD45G/PRKCB/CCL13/BCL2A1/ZAP70/CSNK2B/TRAF1/IKBKG/BCL2L1/TRAF3/TRADD	49
KEGG	hsa04970	Salivary secretion	44/3489	93/8135	0.2227	0.4155	0.2998	CALML5/CALML3/SLC12A2/ATP1B1/CALM3/TRPV6/AQP5/PRKACB/BST1/FXYD2/PLCB2/ATP1B3/KCNMA1/ATP1A1/CST3/GNAQ/CD38/ADCY4/ADCY1/SLC4A2/ITPR3/PRH1/GNAS/ADCY2/PRKACA/NOS1/PRKG1/ITPR1/MUC7/ADCY8/PRKCA/ITPR2/ADCY9/ADRB1/PRKG2/ATP2B1/LYZ/ADCY6/RYR3/CHRM3/PRKCB/CALM2/ATP1B2/SLC9A1	44
KEGG	hsa04966	Collecting duct acid secretion	14/3489	27/8135	0.2263	0.4193	0.3026	ATP6V1C2/ATP6V0A4/CA2/TCIRG1/SLC12A7/ATP6V0E1/ATP6V0E2/ATP6V1C1/ATP6V1G1/ATP6V0A2/ATP6V1B1/CLCNKB/ATP6V1G2/ATP6V1A	14
KEGG	hsa04913	Ovarian steroidogenesis	25/3489	51/8135	0.2272	0.4193	0.3026	HSD17B2/CYP2J2/PRKACB/LDLR/PLA2G4F/CYP11A1/PLA2G4C/STAR/IGF1/ADCY4/ALOX5/CYP1B1/HSD17B7/ADCY1/GNAS/PLA2G4D/ADCY2/PRKACA/SCARB1/ADCY8/ADCY9/AKR1C3/ADCY6/LHCGR/ACOT4	25
KEGG	hsa04721	Synaptic vesicle cycle	37/3489	78/8135	0.2411	0.4408	0.3181	ATP6V1C2/CLTB/ATP6V0A4/AP2A2/SLC6A11/STX2/SLC1A6/TCIRG1/AP2B1/DNM1/AP2M1/SLC1A1/ATP6V0E1/UNC13B/CPLX1/SLC6A12/STX1A/SLC17A7/SYT1/ATP6V0E2/ATP6V1C1/UNC13C/ATP6V1G1/ATP6V0A2/SLC6A9/ATP6V1B1/SLC18A2/SLC6A4/SLC1A3/ATP6V0B/ATP6V1G2/CACNA1A/ATP6V1A/SLC32A1/STXBP1/DNM3/SLC6A2	37
KEGG	hsa05213	Endometrial cancer	28/3489	58/8135	0.2415	0.4408	0.3181	CDH1/ILK/GRB2/CASP9/BRAF/MYC/HRAS/AKT3/RAF1/MAP2K1/GSK3B/AKT1/PIK3CD/EGF/POLK/BAX/EGFR/GADD45A/PIK3R3/MLH1/DDB2/GADD45G/CDKN1A/TCF7L2/MAPK1/TCF7L1/ARAF/PTEN	28
KEGG	hsa04720	Long-term potentiation	32/3489	67/8135	0.2458	0.4461	0.322	CALML5/CALML3/CALM3/PRKACB/RPS6KA2/BRAF/PLCB2/HRAS/RAF1/GNAQ/RAPGEF3/RPS6KA6/MAP2K1/ADCY1/PPP3CC/RAP1B/ITPR3/CAMK2A/PRKACA/PPP1CB/ITPR1/EP300/ADCY8/GRIN2D/PRKCA/ITPR2/PRKCB/CALM2/RAP1A/MAPK1/ARAF/GRIA2	32
KEGG	hsa05321	Inflammatory bowel disease	31/3489	65/8135	0.2538	0.4581	0.3306	GATA3/HLA-DMA/TLR4/RORA/IL18/HLA-DMB/TGFB1/STAT4/RORC/TGFB3/IL10/IL12RB2/NFATC1/IL2RG/TLR5/TLR2/NOD2/HLA-DRB1/HLA-DPA1/NFKB1/IL21R/TGFB2/TBX21/HLA-DOA/SMAD3/HLA-DRA/FOXP3/IL5/IL18R1/IL22/IL23A	31
KEGG	hsa04722	Neurotrophin signaling pathway	55/3489	119/8135	0.2584	0.464	0.3349	CALML5/CALML3/CALM3/SH2B3/MAPK13/RPS6KA2/RAPGEF1/GRB2/BRAF/MAP3K3/NTF4/HRAS/AKT3/MAPK12/MAGED1/ABL1/RAF1/ARHGDIB/RPS6KA6/MAP2K1/GSK3B/RHOA/AKT1/RAP1B/SHC3/IRAK3/CAMK2A/FASLG/TP73/PIK3CD/SHC1/NFKB1/SHC4/MAPK11/BAX/YWHAE/MAPK8/RIPK2/GAB1/NFKBIE/PIK3R3/ARHGDIA/NTF3/SH2B1/PLCG1/NFKBIA/CALM2/MATK/MAP3K1/PSEN2/MAPK14/NTRK1/RAP1A/MAPK1/BDNF	55
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	10/3489	19/8135	0.2637	0.4709	0.3399	BCAT1/GPT2/GOT2/GOT1/AADAT/GPT/IDH3A/IDH2/IDH3G/IDH1	10
KEGG	hsa04936	Alcoholic liver disease	65/3489	142/8135	0.2684	0.4768	0.3441	CYP2E1/TLR4/C1QA/LY96/NOX4/C1QB/C3AR1/LPIN2/C2/C1QC/MAP2K4/CD14/MAPK13/CPT1C/C5AR1/SCD5/TRA2B/ADIPOR1/TAB3/AKT3/MAPK12/ALDH7A1/ACACA/CASP3/ALDH3A2/LPIN1/MAP3K7/PRKAG2/GSK3B/AKT1/CAMKK2/FASLG/ADH6/FOXO1/ADH7/NFKB1/MAPK11/IFNA1/ADH1C/MAPK8/ALDH1B1/ACOX3/LBP/PPARGC1A/TNFRSF1A/MAP3K14/RIPK1/ACOX1/PRKAA1/IRF3/NFKBIA/ALDH2/ADH1B/FADD/IL17RA/C5/MAPK14/MLYCD/ALDH9A1/FASN/TCF7L2/IKBKG/TCF7L1/TRAF3/TRADD	65
KEGG	hsa00120	Primary bile acid biosynthesis	9/3489	17/8135	0.2747	0.4832	0.3487	CYP27A1/CYP39A1/ACOT8/HSD3B7/AMACR/ACOX2/HSD17B4/CYP7B1/CYP46A1	9
KEGG	hsa04060	Cytokine-cytokine receptor interaction	132/3489	295/8135	0.2749	0.4832	0.3487	IL20RB/CXCL14/IL22RA1/IL20RA/IL1F10/IL13RA2/CSF1R/BMP7/CD4/ACVR2A/CCL27/IL18/EPOR/CSF1/IL27RA/TNFSF13/CCL28/TGFBR2/CCR1/ACVRL1/TNFSF12/IL1RL2/IL10RA/TNFRSF1B/TGFB1/TNFSF4/TNFSF8/CCL18/TNFSF11/CCL23/CCL16/CCL21/CD27/TGFB3/IFNAR2/CCL5/IL1RAP/TNFSF13B/ACVR1/IL10/CCR5/IL12RB2/IFNAR1/IL32/BMP2/IL2RG/CCL22/CLCF1/CSF3R/IL15/TNFRSF11B/TGFBR1/TNFRSF10B/CXCL17/TNFRSF17/IL3RA/CXCR4/CD40/TNFRSF19/IL6ST/IL11/CSF2RA/CXCR5/FASLG/TNFRSF10C/CCR10/IL1R2/LTB/CTF1/CSF2RB/CCR2/IL10RB/IL21R/CXCL12/TNFRSF14/CD40LG/TNFSF10/CXCR3/EDAR/CXCL16/EPO/TGFB2/CCL19/THPO/IFNA1/IL20/IL7R/CCL4/BMP5/IL17D/IL7/IL17RE/GDF11/IL1RN/BMPR1B/TNFRSF1A/CX3CR1/TNFRSF21/GH1/IL9/IL13RA1/TNFRSF10D/IL6R/CCR6/CCL7/IL5RA/CXCL5/BMP8A/INHBE/TNFRSF18/CCR4/BMPR2/CCL13/IL33/IL17RA/IL2RA/IL17B/IL5/IL18R1/TNFRSF25/IL22/CXCR1/TNFSF15/IL19/CXCR2/TNFRSF13B/OSMR/CCR7/IL23A/PF4V1/CSF2/IL16	132
KEGG	hsa01212	Fatty acid metabolism	27/3489	57/8135	0.2893	0.506	0.3652	ELOVL4/ELOVL7/ELOVL6/ACSBG1/ACAT2/ELOVL1/ACSL5/HSD17B8/PPT1/CPT1C/SCD5/ACSL3/ACACA/ACSL4/HSD17B4/ACAA2/ACADSB/MECR/ACOX3/ACADS/ACSBG2/ACSL6/PPT2/ACOX1/FASN/ACSL1/TECR	27
KEGG	hsa03450	Non-homologous end-joining	7/3489	13/8135	0.2995	0.521	0.376	PRKDC/DCLRE1C/XRCC5/POLM/RAD50/DNTT/POLL	7
KEGG	hsa04213	Longevity regulating pathway - multiple species	29/3489	62/8135	0.31	0.5355	0.3865	PRKACB/HRAS/AKT3/HSPA6/IGF1/ADCY4/PRKAG2/ADCY1/AKT1/HSPA2/ADCY2/PRKACA/PIK3CD/FOXO1/MTOR/RPS6KB2/ADCY8/ATG5/PIK3R3/ADCY9/FOXA2/PRKAA1/ADCY6/SOD1/RPS6KB1/HDAC1/IRS2/HDAC2/CLPB	29
KEGG	hsa04919	Thyroid hormone signaling pathway	55/3489	121/8135	0.3138	0.5355	0.3865	ATP1B1/SLC2A1/SLC16A10/PRKACB/FXYD2/CASP9/WNT4/PLCB2/MYC/HRAS/ATP1B3/NOTCH2/AKT3/ATP1A1/RAF1/MAP2K1/ITGB3/DIO2/GSK3B/TBC1D4/RXRB/AKT1/PFKFB2/ATP2A3/PRKACA/PIK3CD/FOXO1/NOTCH4/THRB/NCOR1/SIN3A/SLC16A2/MTOR/HDAC3/EP300/PFKP/MED13/PIK3R3/PRKCA/THRA/MDM2/PLCZ1/MED30/HDAC1/PLCG1/PRKCB/MYH7/ATP1B2/MED14/MED4/SLC9A1/HDAC2/MAPK1/MED12/NCOA1	55
KEGG	hsa01240	Biosynthesis of cofactors	69/3489	153/8135	0.3164	0.5355	0.3865	SDR16C5/RDH12/UGT1A6/BCAT1/GGH/PANK1/PSAT1/TPK1/PANK3/NMNAT3/MMAB/VKORC1/MTHFD2L/GUSB/SPR/GMPPA/AK7/AK1/UGP2/PTS/NMNAT1/FPGS/KMO/NME1/COQ3/ALDH3A2/AKR1A1/AK5/NME4/LIPT1/RDH13/MTHFD1L/UGDH/PPCDC/UROD/COX10/GCLC/UMPS/IDO2/GCH1/MOCS1/NADK/SHMT1/MPI/GGCX/PDXK/ALDH1B1/EARS2/AK3/ADSL/AFMID/COQ2/DHRS3/PPOX/ALPL/RGN/MAT1A/NMNAT2/NME3/ALDH2/GPHN/SHMT2/UGT2B17/PANK2/UGT2B28/MOCS2/FECH/DLD/HSD17B6	69
KEGG	hsa04920	Adipocytokine signaling pathway	32/3489	69/8135	0.3192	0.5355	0.3865	ACSBG1/ACSL5/SLC2A1/G6PC3/TNFRSF1B/CPT1C/ADIPOR1/AKT3/ACSL3/PRKAG2/ACSL4/RXRB/AKT1/CAMKK2/NFKB1/MTOR/MAPK8/NFKBIE/PPARGC1A/ACSBG2/TNFRSF1A/ACSL6/STK11/PRKAA1/NFKBIA/NPY/IRS2/ACSL1/PCK2/IKBKG/AGRP/TRADD	32
KEGG	hsa04978	Mineral absorption	28/3489	60/8135	0.3203	0.5355	0.3865	SLC5A1/ATP1B1/SLC46A1/TRPV6/FTH1/FXYD2/FTL/SLC26A9/ATP7A/SLC40A1/SLC30A1/ATP1B3/ATP1A1/STEAP1/SLC8A1/CYBRD1/STEAP2/SLC31A1/SLC11A2/SLC39A4/ATP2B1/MT1X/SLC34A3/VDR/SLC34A2/ATP1B2/HMOX1/SLC8A2	28
KEGG	hsa00330	Arginine and proline metabolism	24/3489	51/8135	0.3205	0.5355	0.3865	ARG1/P4HA2/GATM/P4HA3/SAT2/PRODH/GOT2/ALDH7A1/PYCR2/GOT1/ALDH3A2/P4HA1/AMD1/SMS/NOS1/ALDH1B1/PYCR1/ALDH2/CKB/ALDH9A1/ALDH4A1/SRM/CNDP2/CKMT2	24
KEGG	hsa00220	Arginine biosynthesis	11/3489	22/8135	0.3206	0.5355	0.3865	ARG1/GLS2/GPT2/GOT2/GOT1/GLUL/GPT/NOS1/GLS/ASL/ASS1	11
KEGG	hsa00900	Terpenoid backbone biosynthesis	11/3489	22/8135	0.3206	0.5355	0.3865	HMGCR/HMGCS1/ACAT2/HMGCS2/FDPS/IDI1/PMVK/FNTA/PDSS1/MVK/ZMPSTE24	11
KEGG	hsa00670	One carbon pool by folate	10/3489	20/8135	0.3355	0.5576	0.4024	MTHFD2L/TYMS/ALDH1L2/MTHFD1L/MTHFR/FTCD/MTHFS/SHMT1/MTR/SHMT2	10
KEGG	hsa00591	Linoleic acid metabolism	14/3489	29/8135	0.3424	0.5662	0.4086	PLA2G3/CYP2E1/CYP2J2/PLA2G4F/CYP3A4/PLA2G4C/PLA2G2A/CYP2C9/PLA2G4D/PLA2G2F/PLA2G2D/ALOX15/PLA2G12A/PLA2G1B	14
KEGG	hsa05217	Basal cell carcinoma	29/3489	63/8135	0.3509	0.5773	0.4166	WNT16/WNT3/FZD6/FZD2/WNT4/KIF7/HHIP/FZD3/BMP2/GSK3B/WNT5B/FZD4/WNT5A/WNT2B/POLK/BAX/WNT10A/GADD45A/WNT7B/WNT7A/FZD1/DDB2/GADD45G/CDKN1A/SUFU/WNT1/TCF7L2/TCF7L1/FZD8	29
KEGG	hsa00830	Retinol metabolism	31/3489	68/8135	0.3694	0.6048	0.4365	SDR16C5/RDH12/UGT1A6/CYP3A5/CYP2C18/ALDH1A2/CYP2W1/CYP3A4/RDH16/RDH10/CYP2C9/ALDH1A1/RDH13/CYP3A7/ADH6/ADH7/ADH1C/DHRS3/ALDH1A3/ADH1B/RDH5/UGT2B17/RPE65/UGT2B28/CYP2S1/DHRS9/RETSAT/DGAT1/RDH8/CYP26B1/HSD17B6	31
KEGG	hsa03320	PPAR signaling pathway	34/3489	75/8135	0.3756	0.6119	0.4416	HMGCS1/ACSBG1/CYP27A1/FABP7/ACSL5/PLTP/NR1H3/DBI/ILK/HMGCS2/CPT1C/FABP3/SCD5/ME3/FABP5/ACSL3/ACOX2/OLR1/SLC27A1/ACSL4/RXRB/SLC27A6/ACOX3/ACSBG2/GK2/FABP6/SLC27A4/ACSL6/ACOX1/APOA5/ACSL1/PCK2/APOC3/PPARG	34
KEGG	hsa03440	Homologous recombination	19/3489	41/8135	0.3836	0.6161	0.4446	RBBP8/RAD54B/PALB2/RAD51/MUS81/POLD4/BARD1/BRIP1/TOPBP1/TOP3A/NBN/BRCC3/RPA1/SYCP3/POLD3/RAD51C/SSBP1/RAD50/BRCA1	19
KEGG	hsa04211	Longevity regulating pathway	40/3489	89/8135	0.3857	0.6161	0.4446	CREB3L2/PRKACB/CREB3/HRAS/ADIPOR1/CREB5/AKT3/IGF1/ADCY4/PRKAG2/ADCY1/AKT1/CREB3L1/ADCY2/CAMKK2/PRKACA/PIK3CD/FOXO1/NFKB1/MTOR/BAX/EIF4E/EIF4EBP1/RPS6KB2/ADCY8/ATG5/PPARGC1A/PIK3R3/APPL1/ADCY9/KL/STK11/PRKAA1/RB1CC1/ADCY6/RPS6KB1/ATF6B/CREB3L4/IRS2/PPARG	40
KEGG	hsa00640	Propanoate metabolism	15/3489	32/8135	0.3879	0.6161	0.4446	ACACA/ABAT/HIBCH/LDHB/ACOX3/LDHAL6B/ACADS/ACSS3/ACOX1/PCCA/MLYCD/SUCLG1/MCEE/DLD/LDHA	15
KEGG	hsa04215	Apoptosis - multiple species	15/3489	32/8135	0.3879	0.6161	0.4446	CASP9/PMAIP1/CASP3/BID/APAF1/HTRA2/CYCS/BAX/MAPK8/BCL2L11/TNFRSF1A/FADD/BIRC6/BECN1/BCL2L1	15
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/3489	14/8135	0.3903	0.6161	0.4446	B3GNT7/ST3GAL2/ST3GAL1/CHST6/CHST2/FUT8/CHST1	7
KEGG	hsa04120	Ubiquitin mediated proteolysis	63/3489	142/8135	0.391	0.6161	0.4446	HERC3/RHOBTB1/FBXW7/UBE2K/RHOBTB2/SKP2/DET1/CBLB/UBE2D3/CBLC/FBXO2/UBE2G1/UBA7/CUL1/CDC20/CDC27/NEDD4/KLHL9/CUL2/UBE3C/UBE2NL/UBE4B/MID1/SIAH1/RBX1/CBL/MGRN1/UBE2C/TRIM32/ITCH/CUL4A/CUL7/VHL/SKP1/CDC26/UBE2Q1/CDC34/ANAPC10/SMURF2/UBE2Q2/MDM2/UBE2D4/DDB1/CUL3/ANAPC7/UBE2N/PIAS1/SYVN1/CUL5/DDB2/BIRC6/FBXW8/MAP3K1/ERCC8/UBE2E1/UBE2QL1/PIAS3/KLHL13/BRCA1/UBE4A/PPIL2/UBE2D1/UBA2	63
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	11/3489	23/8135	0.391	0.6161	0.4446	ATP1B1/GLS2/CA2/FXYD2/ATP1B3/ATP1A1/AQP1/GLS/ATP1B2/PCK2/SLC38A3	11
KEGG	hsa01523	Antifolate resistance	14/3489	30/8135	0.4045	0.6342	0.4577	ALOX12/GGH/SLC46A1/FOLR2/FPGS/TYMS/SLC19A1/FOLR3/ABCG2/MTHFR/NFKB1/SHMT1/SHMT2/IKBKG	14
KEGG	hsa05417	Lipid and atherosclerosis	94/3489	215/8135	0.4274	0.6671	0.4814	POU2F3/CALML5/CALML3/TLR4/NCF4/CALM3/LY96/VAV3/IL18/VAV1/MAP2K4/CD14/CYP2J2/CYBA/CYBB/MAPK13/SELP/LDLR/CASP9/PLCB2/HRAS/CCL5/AKT3/VCAM1/HSPA6/MAPK12/NFATC1/MMP3/CASP3/HSP90B1/TNFRSF10B/CYP2C9/FOS/MAP3K7/TLR6/OLR1/ABCA1/EIF2S1/PPP3CC/CD40/GSK3B/RHOA/NCF2/RXRB/TLR2/AKT1/RAP1B/HSPA2/BID/XBP1/CAMK2A/FASLG/APAF1/PIK3CD/DDIT3/LYN/NFKB1/NLRP3/POU2F2/CYCS/CD40LG/TNFSF10/MAPK11/BAX/IFNA1/PYCARD/MAPK8/MMP9/ITPR1/LBP/PIK3R3/TNFRSF1A/PRKCA/HSPA4/VLDLR/NFE2L2/ICAM1/ROCK2/PLCG1/IRF3/ERN1/NFATC3/NFKBIA/CALM2/MAPK14/CASP6/IKBKG/RAP1A/MAPK1/PPARG/BCL2L1/NFATC2/SELE/TRAF3	94
KEGG	hsa04728	Dopaminergic synapse	58/3489	132/8135	0.436	0.6705	0.4839	CALML5/CALML3/CALM3/PPP2R3A/GNAI1/GNAI2/ARRB1/GNG10/CREB3L2/PRKACB/MAPK13/ARRB2/PPP2R2C/GNG2/GNB3/PLCB2/CREB3/GNAI3/CREB5/AKT3/MAPK12/GNAQ/GNG11/FOS/PPP2CA/PPP3CC/GSK3B/AKT1/GNB4/KCNJ6/ITPR3/GNG7/CREB3L1/GNAS/CAMK2A/PRKACA/CACNA1D/PPP2R2B/MAPK11/PPP1CB/GNB1/MAPK8/GNGT2/ITPR1/GNG5/SLC18A2/PRKCA/KCNJ5/ITPR2/PPP2R2A/ATF6B/PRKCB/CALM2/CREB3L4/MAPK14/CACNA1A/PPP2R3C/GRIA2	58
KEGG	hsa05332	Graft-versus-host disease	19/3489	42/8135	0.4368	0.6705	0.4839	HLA-DMA/HLA-DMB/CD86/HLA-C/FASLG/HLA-DRB1/PRF1/HLA-DPA1/HLA-F/HLA-DOA/HLA-DRA/KLRD1/HLA-B/HLA-G/HLA-A/CD28/KIR3DL3/KIR2DL1/GZMB	19
KEGG	hsa04914	Progesterone-mediated oocyte maturation	45/3489	102/8135	0.438	0.6705	0.4839	GNAI1/GNAI2/PRKACB/MAPK13/RPS6KA2/CPEB2/BRAF/GNAI3/AKT3/IGF1/MAPK12/RAF1/RPS6KA6/MAP2K1/ADCY4/CDC27/ADCY1/CCNB1/MAD2L1/AKT1/ADCY2/PRKACA/PIK3CD/CDK1/MAD2L2/MAPK11/CCNB2/CPEB3/CCNA2/MAPK8/CDC26/ADCY8/PIK3R3/ANAPC10/ADCY9/CPEB4/AURKA/KIF22/ADCY6/ANAPC7/STK10/MAPK14/MAPK1/PLK1/ARAF	45
KEGG	hsa00920	Sulfur metabolism	5/3489	10/8135	0.4407	0.6705	0.4839	PAPSS2/BPNT1/SUOX/SELENBP1/PAPSS1	5
KEGG	hsa00565	Ether lipid metabolism	22/3489	49/8135	0.4417	0.6705	0.4839	PLA2G3/PLD1/PLD3/PLA2G4F/LPCAT1/PLA2G4C/PLA2G2A/PAFAH1B1/AGPS/ENPP2/CHPT1/UGT8/PLA2G4D/PLA2G2F/ENPP6/PLA2G2D/PAFAH1B3/GDPD3/PAFAH1B2/PLA2G12A/PLA2G1B/PAFAH2	22
KEGG	hsa05030	Cocaine addiction	22/3489	49/8135	0.4417	0.6705	0.4839	GNAI1/GNAI2/CDK5R1/CREB3L2/PRKACB/CREB3/GNAI3/CREB5/GRM2/FOSB/DLG4/CREB3L1/GNAS/PRKACA/NFKB1/GRIN2D/SLC18A2/ATF6B/CREB3L4/GRM3/BDNF/GRIA2	22
KEGG	hsa04911	Insulin secretion	38/3489	86/8135	0.4444	0.6717	0.4848	ATP1B1/SLC2A1/CREB3L2/RAPGEF4/PRKACB/FXYD2/KCNN3/PLCB2/CREB3/ATP1B3/CREB5/KCNMA1/ATP1A1/KCNMB1/GNAQ/ADCY4/ADCY1/GCK/STX1A/ITPR3/CREB3L1/GNAS/ADCY2/KCNMB3/CAMK2A/PRKACA/CACNA1D/ADCY8/PCLO/PRKCA/ADCY9/ADCY6/ADCYAP1/ATF6B/CHRM3/PRKCB/CREB3L4/ATP1B2	38
KEGG	hsa03250	Viral life cycle - HIV-1	28/3489	63/8135	0.4489	0.6754	0.4874	CD4/BICD2/SAMHD1/SERINC5/BICD1/MAP1S/APOBEC3G/APOBEC3F/BST2/MAP1A/CHMP4B/CCR5/CXCR4/SMARCB1/PSIP1/ELL2/PPIA/TSG101/RAN/VPS4B/EP300/PIN1/AFF4/APOBEC3C/CPSF6/SERINC3/APOBEC3B/CDK9	28
KEGG	hsa05100	Bacterial invasion of epithelial cells	34/3489	77/8135	0.4541	0.6781	0.4894	CDH1/ARPC5L/HCLS1/CLTB/ARPC1B/ITGA5/ILK/FN1/ELMO1/DNM1/ELMO3/ARPC1A/CD2AP/ARPC5/RHOA/PXN/SHC3/RHOG/PIK3CD/CBL/ACTR3C/MAD2L2/SHC1/SHC4/GAB1/CAV1/ARPC2/PIK3R3/ELMO2/VCL/WASF2/CTTN/DNM3/ACTR2	34
KEGG	hsa00450	Selenocompound metabolism	8/3489	17/8135	0.4547	0.6781	0.4894	PAPSS2/MARS2/SCLY/TXNRD2/MTR/PSTK/PAPSS1/SEPHS2	8
KEGG	hsa00564	Glycerophospholipid metabolism	43/3489	98/8135	0.4598	0.6825	0.4926	CDS1/PLA2G3/MBOAT2/PLD1/LPIN2/AGPAT4/PLD3/PLA2G15/MBOAT1/AGPAT1/PLA2G4F/CHKA/CDS2/LPCAT1/LYPLA1/PLA2G4C/PLA2G2A/DGKA/LPIN1/LPGAT1/CHPT1/DGKD/PGS1/PCYT1A/PLA2G4D/DGKI/LCLAT1/PLA2G2F/PLA2G2D/CRLS1/GPD2/PNPLA6/GPAT2/DGKZ/PLA2G12A/CDIPT/PLA2G1B/CHKB/TAZ/ETNK1/PTDSS2/AGPAT2/DGKG	43
KEGG	hsa05310	Asthma	14/3489	31/8135	0.467	0.6902	0.4981	HLA-DMA/FCER1G/FCER1A/HLA-DMB/IL10/PRG2/CD40/HLA-DRB1/HLA-DPA1/CD40LG/HLA-DOA/HLA-DRA/IL9/IL5	14
KEGG	hsa04657	IL-17 signaling pathway	41/3489	94/8135	0.4826	0.7101	0.5125	S100A7/MAPK6/MAPK13/TAB3/MAPK12/MMP3/CASP3/HSP90B1/DEFB4A/FOS/TRAF5/MAP3K7/FOSB/GSK3B/S100A7A/LCN2/MMP13/NFKB1/TRAF4/MAPK11/MAPK8/MMP9/IL17D/IL17RE/CCL7/CXCL5/NFKBIA/FADD/IL17RA/IL17B/IL5/FOSL1/MAPK14/USP25/S100A9/S100A8/IKBKG/MAPK1/CSF2/TRAF3/TRADD	41
KEGG	hsa00350	Tyrosine metabolism	16/3489	36/8135	0.4887	0.7146	0.5158	TYRP1/DCT/ALDH3B2/ALDH3A1/TYR/GOT2/FAHD1/ALDH3B1/GOT1/ADH6/ADH7/GSTZ1/ADH1C/ADH1B/FAH/AOC2	16
KEGG	hsa04940	Type I diabetes mellitus	19/3489	43/8135	0.49	0.7146	0.5158	HLA-DMA/PTPRN2/HLA-DMB/CD86/HLA-C/FASLG/HLA-DRB1/PRF1/HLA-DPA1/HLA-F/HLA-DOA/HLA-DRA/HLA-B/HLA-G/HLA-A/CD28/GZMB/PTPRN/GAD2	19
KEGG	hsa01232	Nucleotide metabolism	37/3489	85/8135	0.494	0.7174	0.5178	GDA/ENTPD6/ADK/ENTPD3/NUDT16/ADA/AK7/TK2/AK1/NT5E/XDH/ENTPD1/NME1/TYMS/GMPR2/AK5/NME4/ENPP1/CANT1/ASMTL/AMPD2/UCK2/RRM1/IMPDH1/AK3/AMPD1/GMPS/ADSL/UCK1/UPP2/NME3/ENTPD2/NT5M/DGUOK/HDDC2/RRM2/RRM2B	37
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	12/3489	27/8135	0.5087	0.7355	0.5308	FUT4/FUT1/FUT2/ST3GAL6/A4GALT/B3GNT4/B3GNT5/ST3GAL4/FUT3/B3GALNT1/B3GNT3/FUT7	12
KEGG	hsa00230	Purine metabolism	55/3489	128/8135	0.5269	0.7548	0.5448	PAPSS2/GDA/PGM2/ENTPD6/ADK/PDE1A/ENTPD3/PRPS1/NUDT16/ADA/AK7/AK1/NT5E/ENPP4/XDH/ENTPD1/PDE1C/NME1/GMPR2/AK5/ADCY4/ADCY1/NME4/PDE2A/ENPP1/CANT1/NPR1/PDE7B/ADCY2/AMPD2/PAICS/RRM1/IMPDH1/AK3/PDE4A/AMPD1/GMPS/ADSL/ADCY8/PDE5A/ADCY9/ADCY6/GUCY2C/NME3/ENTPD2/PDE7A/NT5M/DGUOK/PGM1/PAPSS1/HDDC2/RRM2/RRM2B/PRPS2/NUDT9	55
KEGG	hsa04136	Autophagy - other	14/3489	32/8135	0.5285	0.7548	0.5448	ATG9B/PPP2CA/ATG12/GABARAPL1/GABARAP/MTOR/ATG4D/ATG5/WIPI1/ATG16L1/PIK3R4/BECN1/ATG7/GABARAPL2	14
KEGG	hsa04922	Glucagon signaling pathway	46/3489	107/8135	0.5288	0.7548	0.5448	CALML5/CALML3/SIK1/CALM3/SLC2A1/CREB3L2/G6PC3/PRKACB/CPT1C/PLCB2/FBP1/CREB3/CREB5/AKT3/PHKA1/GNAQ/ACACA/PRKAG2/PPP3CC/GCK/AKT1/ITPR3/CREB3L1/GNAS/ADCY2/PHKB/CAMK2A/PRKACA/FOXO1/LDHB/PYGM/LDHAL6B/ITPR1/EP300/PFKP/PPARGC1A/ITPR2/CRTC2/PRKAA1/CALM2/CREB3L4/PHKG1/PCK2/PDHB/PYGL/LDHA	46
KEGG	hsa00592	alpha-Linolenic acid metabolism	11/3489	25/8135	0.5319	0.7559	0.5456	PLA2G3/PLA2G4F/PLA2G4C/PLA2G2A/PLA2G4D/PLA2G2F/PLA2G2D/ACOX3/PLA2G12A/PLA2G1B/ACOX1	11
KEGG	hsa05143	African trypanosomiasis	16/3489	37/8135	0.5457	0.7627	0.5505	F2RL1/IL18/LAMA4/PLCB2/VCAM1/IL10/GNAQ/HPR/FASLG/APOL1/IDO2/PRKCA/ICAM1/PRKCB/NPPA/SELE	16
KEGG	hsa04114	Oocyte meiosis	56/3489	131/8135	0.5468	0.7627	0.5505	CALML5/CALML3/CALM3/CCNE2/PRKACB/MAPK13/RPS6KA2/CPEB2/PTTG1/SLK/YWHAZ/IGF1/MAPK12/STAG3/CUL1/CDC20/RPS6KA6/MAP2K1/ADCY4/CDC27/PPP2CA/ADCY1/CCNB1/CCNE1/PPP3CC/MAD2L1/ITPR3/ADCY2/CAMK2A/RBX1/PRKACA/CDK1/MAD2L2/ESPL1/MAPK11/CCNB2/CPEB3/PPP1CB/YWHAE/SKP1/CDC26/ITPR1/ADCY8/ANAPC10/ITPR2/ADCY9/CPEB4/AURKA/PLCZ1/ADCY6/ANAPC7/CALM2/SMC3/MAPK14/MAPK1/PLK1	56
KEGG	hsa00020	Citrate cycle (TCA cycle)	13/3489	30/8135	0.5503	0.7627	0.5505	OGDH/SDHA/DLAT/IDH3A/FH/IDH2/IDH3G/IDH1/SUCLG1/PCK2/MDH2/PDHB/DLD	13
KEGG	hsa00053	Ascorbate and aldarate metabolism	13/3489	30/8135	0.5503	0.7627	0.5505	UGT1A6/GUSB/ALDH7A1/ALDH3A2/AKR1A1/UGDH/ALDH1B1/KL/RGN/ALDH2/UGT2B17/ALDH9A1/UGT2B28	13
KEGG	hsa00310	Lysine degradation	27/3489	63/8135	0.5504	0.7627	0.5505	BBOX1/PLOD1/ACAT2/PLOD2/EZH2/PLOD3/PRDM6/ALDH7A1/ALDH3A2/SUV39H2/SETDB2/AADAT/SMYD2/ALDH1B1/PRDM2/PIPOX/SETDB1/PRDM16/GCDH/MECOM/ALDH2/SETD2/ALDH9A1/SETD7/AASS/DLD/TMLHE	27
KEGG	hsa05164	Influenza A	73/3489	171/8135	0.5508	0.7627	0.5505	PRSS3/PRSS2/HLA-DMA/TLR4/RAB11A/TMPRSS2/IL18/TLR7/SLC25A5/HLA-DMB/CASP9/TMPRSS4/FDPS/IFNAR2/CCL5/RNASEL/AKT3/IFNAR1/RAF1/CASP3/DNAJB1/MAP2K1/TNFRSF10B/NXF3/EIF2S1/AKT1/TRIM25/BID/FASLG/HLA-DRB1/APAF1/PIK3CD/HLA-DPA1/NFKB1/NLRP3/CYCS/TNFSF10/BAX/TMPRSS11D/IFNA1/PYCARD/HLA-DOA/NXT2/CDK4/IFIH1/VDAC1/HLA-DRA/EP300/PIK3R3/RAB11B/TNFRSF1A/PRKCA/NXF2/NLRX1/CALCOCO2/RAE1/ICAM1/TPSD1/IRF3/NFKBIA/PRKCB/IL33/FADD/PLG/TYK2/IKBKG/MAPK1/TLR3/HNRNPUL1/CDK6/JAK1/TRAF3/TRADD	73
KEGG	hsa05160	Hepatitis C	67/3489	157/8135	0.5526	0.7627	0.5505	CLDN1/CLDN8/OCLN/NR1H3/CLDN10/CLDN4/LDLR/PPP2R2C/GRB2/CASP9/BRAF/MYC/HRAS/IFNAR2/RNASEL/AKT3/YWHAZ/IFNAR1/CD81/RAF1/CASP3/E2F3/MAP2K1/PPP2CA/EIF2S1/GSK3B/AKT1/BID/FASLG/APAF1/PIK3CD/EGF/NFKB1/PPP2R2B/CLDN16/CYCS/BAX/YWHAE/CLDN19/IFNA1/SCARB1/EIF2AK4/CLDN5/CDK4/EGFR/PIK3R3/TNFRSF1A/PPP2R2A/RIPK1/RB1/PIAS1/IRF3/NFKBIA/FADD/CDKN1A/CLDN23/TYK2/CLDN7/IKBKG/MAPK1/TLR3/CLDN3/CDK6/JAK1/ARAF/TRAF3/TRADD	67
KEGG	hsa04614	Renin-angiotensin system	10/3489	23/8135	0.557	0.7655	0.5525	KLK1/ACE/PREP/ACE2/PRCP/ENPEP/AGT/MME/CTSA/AGTR1	10
KEGG	hsa04024	cAMP signaling pathway	94/3489	221/8135	0.569	0.7743	0.5588	CALML5/CALML3/ATP1B1/CALM3/VAV3/PTGER2/PLD1/VAV1/GNAI1/GNAI2/CREB3L2/RRAS/RAPGEF4/PRKACB/FXYD2/BRAF/SOX9/TNNI3/CREB3/TIAM1/HHIP/GNAI3/ATP1B3/CREB5/AKT3/ATP1A1/RAC2/NFATC1/RAF1/RAPGEF3/F2R/ARAP3/MAP2K1/FOS/ADCY4/ADCY1/RHOA/MYL9/AKT1/RAP1B/CFTR/NPR1/CREB3L1/CNGA1/OXTR/GNAS/FXYD1/ADCY2/ATP2A3/CAMK2A/EDN3/PRKACA/PIK3CD/CACNA1D/NFKB1/PPP1CB/ROCK1/MAPK8/ACOX3/PDE4A/NPY1R/EP300/ADCY8/PIK3R3/GRIN2D/GABBR1/ADCY9/ADRB1/VIP/SUCNR1/ATP2B1/GABBR2/ACOX1/ADORA1/ADCY6/ADCYAP1/LHCGR/ROCK2/CHRM1/NFKBIA/CALM2/HTR1A/CREB3L4/NPY/ATP1B2/EDN1/SLC9A1/RAP1A/MAPK1/BDNF/PAK1/GPHA2/NPPA/GRIA2	94
KEGG	hsa04152	AMPK signaling pathway	51/3489	120/8135	0.5696	0.7743	0.5588	HMGCR/PPP2R3A/CREB3L2/G6PC3/TBC1D1/PPP2R2C/CPT1C/FBP1/CREB3/SCD5/ADIPOR1/CREB5/AKT3/IGF1/ACACA/PPP2CA/MAP3K7/PRKAG2/AKT1/CFTR/PFKFB2/RAB10/CREB3L1/CAMKK2/PIK3CD/FOXO1/STRADA/EEF2K/PPP2R2B/MTOR/STRADB/CCNA2/EIF4EBP1/RPS6KB2/PFKP/PPARGC1A/PIK3R3/RAB11B/PPP2R2A/RAB14/CRTC2/STK11/PRKAA1/RPS6KB1/CREB3L4/MLYCD/IRS2/FASN/PCK2/PPARG/PPP2R3C	51
KEGG	hsa00514	Other types of O-glycan biosynthesis	20/3489	47/8135	0.5743	0.7743	0.5588	GALNT3/GALNT10/C1GALT1C1/PLOD3/MFNG/C1GALT1/GALNT14/GALNT5/GXYLT2/GALNT2/GALNT7/POMT1/GALNT12/GXYLT1/GALNT6/RFNG/GALNT4/ST6GAL2/OGT/GALNTL5	20
KEGG	hsa04973	Carbohydrate digestion and absorption	20/3489	47/8135	0.5743	0.7743	0.5588	SLC5A1/ATP1B1/G6PC3/FXYD2/PLCB2/HK3/ATP1B3/AKT3/ATP1A1/LCT/SLC2A5/AKT1/PIK3CD/CACNA1D/MGAM/PIK3R3/SLC37A4/PRKCB/ATP1B2/HK1	20
KEGG	hsa05162	Measles	59/3489	139/8135	0.5749	0.7743	0.5588	TLR4/FCGR2B/TLR7/CCNE2/CSNK2A2/CASP9/IFNAR2/CBLB/AKT3/HSPA6/IFNAR1/IL2RG/CASP3/CD3E/STAT5A/FOS/MAP3K7/CCNE1/EIF2S1/GSK3B/TLR2/AKT1/HSPA2/BID/FASLG/TP73/APAF1/SLAMF1/PIK3CD/MSN/NFKB1/CYCS/BAX/CD3D/IFNA1/MAPK8/EIF2AK4/CDK4/IFIH1/CCND2/CD3G/PIK3R3/CD46/CD28/RAB9B/IRF3/NFKBIA/CSNK2A1/FADD/CSNK2B/IL2RA/STAT5B/TYK2/IKBKG/BCL2L1/CDK6/JAK1/TRAF3/TRADD	59
KEGG	hsa04330	Notch signaling pathway	25/3489	59/8135	0.5817	0.7795	0.5626	APH1B/DLL1/HES1/RBPJ/MFNG/NOTCH2/CTBP2/NCOR2/HEYL/JAG1/NOTCH4/HES5/TLE4/HEY2/TLE3/EP300/DTX3/HDAC1/RFNG/PSEN2/NCSTN/HDAC2/MAML2/JAG2/TLE2	25
KEGG	hsa04612	Antigen processing and presentation	33/3489	78/8135	0.5846	0.7795	0.5626	HLA-DMA/CD4/LGMN/IFI30/HLA-DMB/CTSS/TAPBP/RFX5/CTSB/HSPA6/CD8A/CD74/HLA-C/HSPA2/CANX/HLA-DRB1/HLA-DPA1/HLA-F/HLA-DOA/HLA-DRA/KLRD1/HLA-B/KLRC4/HSPA4/CD8B/RFXAP/HLA-G/HLA-A/B2M/KIR3DL3/KLRC3/KIR2DL1/KIR2DL4	33
KEGG	hsa00051	Fructose and mannose metabolism	14/3489	33/8135	0.5877	0.7795	0.5626	SORD/AKR1B1/TSTA3/GMPPA/AKR1B10/FBP1/GMDS/HK3/KHK/PFKFB2/MPI/PFKP/ALDOC/HK1	14
KEGG	hsa03015	mRNA surveillance pathway	41/3489	97/8135	0.5881	0.7795	0.5626	PPP2R3A/ETF1/PPP2R2C/PABPC1/GSPT2/EIF4A3/PCF11/PELO/PPP2CA/NXF3/WDR33/RNMT/PPP2R2B/CSTF3/PPP1CB/PABPC5/MAGOH/NXT2/CSTF2/CSTF2T/MAGOHB/PABPC3/NXF2/PPP2R2A/SMG1/SAP18/CPSF3/UPF2/PABPC1L2B/CPSF6/PABPC4/GSPT1/UPF3A/FUS/RNGTT/ACIN1/UPF1/PPP2R3C/CASC3/SYMPK/CPSF2	41
KEGG	hsa03022	Basal transcription factors	19/3489	45/8135	0.5927	0.7824	0.5647	CDK7/TAF7L/GTF2F2/TAF4B/GTF2IRD1/GTF2H3/GTF2H1/TAF2/TAF15/GTF2H2/TAF6/TAF5/GTF2B/GTF2H4/TAF3/GTF2F1/TAF4/GTF2E2/GTF2E1	19
KEGG	hsa05134	Legionellosis	24/3489	57/8135	0.5979	0.7862	0.5674	TLR4/IL18/ITGAM/CD14/NLRC4/ITGB2/CASP9/HSPA6/CASP3/TLR5/TLR2/SEC22B/HSPA2/NAIP/APAF1/NFKB1/CYCS/CR1/RAB1A/VCP/PYCARD/NFKBIA/EEF1A2/SAR1A	24
KEGG	hsa00510	N-Glycan biosynthesis	21/3489	50/8135	0.6041	0.7882	0.5688	MAN1A1/MGAT1/MGAT4A/MGAT2/MAN1C1/ALG6/SRD5A3/DOLK/FUT8/ALG5/DPM1/DAD1/MAN1B1/DPAGT1/GANAB/MOGS/RPN2/DPM3/ALG3/ST6GAL2/STT3A	21
KEGG	hsa04979	Cholesterol metabolism	21/3489	50/8135	0.6041	0.7882	0.5688	CYP27A1/NCEH1/NPC2/PLTP/LRP1/LDLR/STAR/ABCA1/LRPAP1/PCSK9/APOC1/SOAT1/SCARB1/CETP/VDAC1/APOE/STARD3/LPA/APOC2/APOC3/LIPG	21
KEGG	hsa00500	Starch and sucrose metabolism	15/3489	36/8135	0.6215	0.8041	0.5803	PGM2/G6PC3/GAA/HK3/UGP2/PGM2L1/ENPP1/GCK/GYG1/GPI/PYGM/MGAM/PGM1/HK1/PYGL	15
KEGG	hsa04977	Vitamin digestion and absorption	10/3489	24/8135	0.6246	0.8041	0.5803	TCN2/SLC46A1/SLC23A1/SLC19A2/FOLH1/SLC19A1/SCARB1/CUBN/RBP2/BTD	10
KEGG	hsa00982	Drug metabolism - cytochrome P450	30/3489	72/8135	0.6273	0.8041	0.5803	GSTO2/UGT1A6/ALDH3B2/CYP3A5/CYP2E1/GSTA3/ALDH3A1/GSTA4/CYP3A4/ALDH3B1/CYP2C9/MGST2/FMO5/GSTO1/GSTP1/ADH6/FMO3/ADH7/FMO1/FMO2/FMO4/MGST3/ADH1C/GSTT2/GSTT1/ADH1B/UGT2B17/UGT2B28/HPGDS/GSTM5	30
KEGG	hsa04137	Mitophagy - animal	30/3489	72/8135	0.6273	0.8041	0.5803	ATG9B/RRAS/CSNK2A2/CITED2/HRAS/USP30/SQSTM1/MAP1LC3C/RHOT1/GABARAPL1/GABARAP/MRAS/TFEB/TFE3/USP8/MFN1/RAB7B/FUNDC1/MAPK8/ATG5/NBR1/TBC1D17/CALCOCO2/CSNK2A1/TBC1D15/CSNK2B/MFN2/BECN1/BCL2L1/GABARAPL2	30
KEGG	hsa04723	Retrograde endocannabinoid signaling	62/3489	148/8135	0.6284	0.8041	0.5803	GNAI1/GABRP/GNAI2/GNG10/PRKACB/MAPK13/GABRB2/GNG2/GNB3/PLCB2/GNAI3/MAPK12/GNAQ/GNG11/ADCY4/ADCY1/GABRR2/GNB4/KCNJ6/ITPR3/GNG7/SLC17A7/ADCY2/PRKACA/CACNA1D/ABHD6/MAPK11/GABRQ/NDUFA7/GNB1/GABRB1/MAPK8/DAGLA/GNGT2/ITPR1/NDUFV2/ADCY8/GNG5/PRKCA/MGLL/KCNJ5/ITPR2/NDUFB9/ADCY9/NDUFS7/FAAH/GABRE/NDUFB1/ADCY6/NDUFB4/PRKCB/MAPK14/NDUFC1/NDUFA6/CACNA1A/MAPK1/GABRR1/SLC32A1/NDUFA12/NDUFA4L2/NDUFA9/GRIA2	62
KEGG	hsa05320	Autoimmune thyroid disease	22/3489	53/8135	0.6317	0.8048	0.5808	HLA-DMA/HLA-DMB/CD86/IL10/HLA-C/CD40/FASLG/HLA-DRB1/PRF1/HLA-DPA1/CD40LG/HLA-F/IFNA1/HLA-DOA/HLA-DRA/HLA-B/HLA-G/HLA-A/CD28/TG/IL5/GZMB	22
KEGG	hsa01200	Carbon metabolism	48/3489	115/8135	0.6337	0.8048	0.5808	PSAT1/ACAT2/ESD/OGDH/ENO2/GPT2/PRPS1/FBP1/HK3/ME3/GOT2/PHGDH/SDS/GOT1/SDSL/ME2/HIBCH/SDHA/GCK/GPI/DLAT/GPT/IDH3A/FH/IDH2/SHMT1/ACOX3/ACADS/PFKP/ALDOC/ADPGK/ACOX1/RGN/PCCA/ENO3/PGLS/GLYCTK/IDH3G/SHMT2/IDH1/AGXT/SUCLG1/MCEE/MDH2/PDHB/HK1/PRPS2/DLD	48
KEGG	hsa04621	NOD-like receptor signaling pathway	77/3489	184/8135	0.6409	0.8092	0.584	CARD18/TLR4/CARD8/IL18/PKN1/ANTXR2/TRPV2/PSTPIP1/CYBA/CYBB/NLRC4/MAPK13/NLRP12/TRPM2/PYDC1/PLCB2/IFNAR2/CTSB/CCL5/RNASEL/TAB3/MAPK12/IFNAR1/DEFB4A/MAP1LC3C/TRAF5/MAP3K7/ATG12/GSDMD/CARD16/RHOA/NOD2/GABARAPL1/ITPR3/NAIP/GABARAP/TXN/NFKB1/NLRP3/NAMPT/MFN1/P2RX7/MAPK11/YWHAE/IFNA1/PYCARD/MAPK8/RIPK2/VDAC1/ITPR1/SHARPIN/ATG5/GBP4/ITPR2/NLRX1/BRCC3/ATG16L1/RIPK1/SUGT1/IRF3/NFKBIA/GBP5/FADD/MFN2/MAPK14/RIPK3/TYK2/NOD1/IKBKG/TP53BP1/MAPK1/RBCK1/BCL2L1/GABARAPL2/JAK1/NLRP7/TRAF3	77
KEGG	hsa04917	Prolactin signaling pathway	29/3489	70/8135	0.642	0.8092	0.584	ELF5/MAPK13/GRB2/TNFSF11/HRAS/AKT3/MAPK12/RAF1/MAP2K1/STAT5A/FOS/GSK3B/GCK/AKT1/SHC3/PIK3CD/SHC1/NFKB1/SHC4/MAPK11/SOCS2/MAPK8/SOCS6/CCND2/PIK3R3/LHCGR/MAPK14/STAT5B/MAPK1	29
KEGG	hsa00910	Nitrogen metabolism	7/3489	17/8135	0.6466	0.8119	0.5859	CA6/CA12/CA2/CA14/CA13/CA5B/GLUL	7
KEGG	hsa01230	Biosynthesis of amino acids	31/3489	75/8135	0.6501	0.8124	0.5863	ARG1/BCAT1/PSAT1/ENO2/GPT2/PRPS1/GOT2/PHGDH/CBS/PYCR2/SDS/GOT1/SDSL/GLUL/GPT/IDH3A/IDH2/SHMT1/PYCR1/PFKP/ALDOC/MTR/ASNS/MAT1A/ENO3/IDH3G/SHMT2/IDH1/ASL/ASS1/PRPS2	31
KEGG	hsa04260	Cardiac muscle contraction	36/3489	87/8135	0.6518	0.8124	0.5863	CACNA2D4/ATP1B1/TNNT2/FXYD2/COX7B/TNNI3/ATP1B3/ATP1A1/SLC8A1/HRC/ASPH/ATP2A3/CACNA2D2/CACNB1/CACNA1D/UQCRC2/CACNB4/COX6B2/COX7A1/COX4I2/TPM2/COX5A/TNNC1/COX6C/MYH7/MYL2/COX7B2/TPM1/ATP1B2/TRDN/SLC9A1/UQCRH/COX5B/UQCRFS1/CACNB2/SLC8A2	36
KEGG	hsa00983	Drug metabolism - other enzymes	33/3489	80/8135	0.6578	0.8161	0.589	GSTO2/UGT1A6/CYP2E1/GSTA3/GSTA4/GUSB/CYP3A4/TK2/XDH/NME1/MGST2/NME4/GSTO1/GSTP1/UMPS/UCK2/RRM1/IMPDH1/MGST3/GSTT2/TPMT/GMPS/UCK1/GSTT1/UPP2/NAT2/NME3/UGT2B17/UGT2B28/DPYD/RRM2/GSTM5/RRM2B	33
KEGG	hsa00062	Fatty acid elongation	11/3489	27/8135	0.6597	0.8161	0.589	ELOVL4/ELOVL7/ELOVL6/ELOVL1/PPT1/THEM5/ACAA2/MECR/PPT2/ACOT4/TECR	11
KEGG	hsa00730	Thiamine metabolism	6/3489	15/8135	0.6827	0.8399	0.6062	TPK1/AK7/AK1/AK5/THTPA/ALPL	6
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	88/3489	212/8135	0.684	0.8399	0.6062	KLF5/GSTO2/EPHX3/UGT1A6/GSTA3/KLF4/PAQR7/DLL1/GNAI1/AIP/GNAI2/ARRB1/CREB3L2/PRKACB/RPS6KA2/ARRB2/GSTA4/GRB2/PAQR8/CYP3A4/TNFSF11/MYC/CREB3/FGF18/GNAI3/HRAS/CHRNA9/CREB5/NOTCH2/AKT3/EPHX1/RAF1/RPS6KA6/HSP90B1/MAP2K1/EPHX2/STAT5A/FOS/ADCY4/CYP1B1/ADCY1/MGST2/ARNT/RXRB/AKT1/GSTO1/JAG1/CREB3L1/GNAS/FGF10/ADCY2/PRKACA/PIK3CD/CACNA1D/EGF/CHRNA3/NFKB1/MTOR/MGST3/GSTT2/EGFR/EIF4EBP1/RPS6KB2/ADCY8/PIK3R3/PRKCA/KPNA3/ADCY9/ADRB1/GSTT1/RB1/ADCY6/RPS6KB1/ATF6B/PRKCB/CDC6/CREB3L4/UGT2B17/VDR/WNT1/UGT2B28/STAT5B/EPHX4/FGF17/CACNA1A/MAPK1/GSTM5/FGF6	88
KEGG	hsa04929	GnRH secretion	26/3489	64/8135	0.6876	0.8413	0.6072	ARRB1/SPP1/ARRB2/KCNN3/PLCB2/HRAS/AKT3/RAF1/GNAQ/MAP2K1/AKT1/KCNJ6/ITPR3/HCN3/PIK3CD/CACNA1D/TRPC1/ITPR1/PIK3R3/PRKCA/GABBR1/KCNJ5/ITPR2/GABBR2/PRKCB/MAPK1	26
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	12/3489	30/8135	0.6905	0.8417	0.6075	ACAT2/GLUL/SHMT1/AFMID/HYI/PCCA/GLYCTK/SHMT2/AGXT/MCEE/MDH2/DLD	12
KEGG	hsa00260	Glycine, serine and threonine metabolism	16/3489	40/8135	0.6998	0.85	0.6134	PSAT1/GATM/PHGDH/ALDH7A1/CBS/SDS/SDSL/SRR/SHMT1/PIPOX/DMGDH/GLYCTK/SHMT2/AGXT/AOC2/DLD	16
KEGG	hsa03060	Protein export	9/3489	23/8135	0.7147	0.8649	0.6242	SEC11A/SEC63/SRP68/SEC62/IMMP1L/SRP72/SRP14/SEC61A1/SRPRB	9
KEGG	hsa04620	Toll-like receptor signaling pathway	42/3489	104/8135	0.731	0.8814	0.6361	TLR4/LY96/TLR7/MAP2K4/CD14/SPP1/CD86/MAPK13/TLR8/IFNAR2/CCL5/AKT3/MAPK12/IFNAR1/TLR1/MAP2K1/FOS/MAP3K7/TLR6/TLR5/CD40/TLR2/AKT1/PIK3CD/NFKB1/MAPK11/IFNA1/MAPK8/CCL4/LBP/CTSK/IRF5/PIK3R3/RIPK1/IRF3/NFKBIA/FADD/MAPK14/IKBKG/MAPK1/TLR3/TRAF3	42
KEGG	hsa04710	Circadian rhythm	12/3489	31/8135	0.7411	0.8881	0.641	RORA/BHLHE41/RORC/NPAS2/CUL1/PRKAG2/RBX1/SKP1/CSNK1D/BHLHE40/CSNK1E/PRKAA1	12
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	14/3489	36/8135	0.7419	0.8881	0.641	NMNAT3/BST1/NNMT/NT5E/NMNAT1/CD38/ENPP1/NAMPT/NADK/SIRT3/NMNAT2/NNT/NT5M/NUDT12	14
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	31/3489	78/8135	0.7504	0.8935	0.6449	GSTO2/UGT1A6/ALDH3B2/CYP3A5/CYP2E1/GSTA3/ALDH3A1/CBR1/GSTA4/CYP3A4/EPHX1/ALDH3B1/CYP2C9/CYP1B1/MGST2/GSTO1/AKR7A2/GSTP1/ADH6/ADH7/MGST3/ADH1C/GSTT2/GSTT1/ADH1B/AKR7A3/UGT2B17/UGT2B28/CYP2S1/HPGDS/GSTM5	31
KEGG	hsa00360	Phenylalanine metabolism	6/3489	16/8135	0.7517	0.8935	0.6449	ALDH3B2/ALDH3A1/GOT2/ALDH3B1/GOT1/AOC2	6
KEGG	hsa00040	Pentose and glucuronate interconversions	13/3489	34/8135	0.7637	0.9045	0.6528	UGT1A6/SORD/AKR1B1/GUSB/AKR1B10/UGP2/AKR1A1/CRYL1/UGDH/KL/UGT2B17/UGT2B28/XYLB	13
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/3489	11/8135	0.7679	0.9063	0.6541	VKORC1/COQ3/GGCX/COQ2	4
KEGG	hsa05031	Amphetamine addiction	27/3489	69/8135	0.7742	0.9073	0.6548	CALML5/CALML3/CALM3/CREB3L2/PRKACB/CREB3/CREB5/FOS/PPP3CC/FOSB/STX1A/CREB3L1/GNAS/CAMK2A/PRKACA/CACNA1D/PPP1CB/GRIN2D/SLC18A2/PRKCA/ATF6B/HDAC1/PRKCB/CALM2/CREB3L4/HDAC2/GRIA2	27
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	27/3489	69/8135	0.7742	0.9073	0.6548	GSTO2/UGT1A6/CYP3A5/CYP2E1/GSTA3/CYP2C18/CBR1/GSTA4/CYP3A4/EPHX1/SULT1A1/CYP2C9/SULT1A2/CYP1B1/MGST2/GSTO1/CYP3A7/GSTP1/MGST3/GSTT2/CYP3A43/GSTT1/NAT2/UGT2B17/UGT2B28/HPGDS/GSTM5	27
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	10/3489	27/8135	0.7898	0.9224	0.6657	ELOVL4/ELOVL7/ELOVL6/ELOVL1/SCD5/HSD17B4/ACOX3/ACOX1/ACOT4/TECR	10
KEGG	hsa04140	Autophagy - animal	56/3489	141/8135	0.803	0.9297	0.671	ATG9B/DAPK1/RRAS/PRKACB/HRAS/CTSB/AKT3/SQSTM1/RAF1/MAP2K1/MAP1LC3C/PPP2CA/MAP3K7/ATG12/EIF2S1/MTMR4/AKT1/GABARAPL1/STX17/CAMKK2/PRKACA/PIK3CD/GABARAP/MTMR14/MRAS/MTOR/CTSD/RAB7B/RAB1A/ATG4D/MAPK8/EIF2AK4/ITPR1/RPS6KB2/ATG5/PIK3R3/RRAGC/ZFYVE1/WIPI1/ATG16L1/STK11/LAMP2/PIK3R4/PRKAA1/RB1CC1/RPS6KB1/ERN1/BECN1/RRAGB/ATG7/IRS2/MAPK1/BCL2L1/GABARAPL2/UVRAG/PTEN	56
KEGG	hsa03010	Ribosome	63/3489	158/8135	0.8033	0.9297	0.671	RPLP1/RPL36/RPLP0/RPL35A/MRPL15/RPS19/RPL13/RPS7/RPL36A/RPL35/RPL11/RPS27L/RPL10/RPL7A/RPL14/RPL10A/RPL27A/RPS18/RPL23/RPS13/MRPL21/MRPL14/MRPS14/RPL4/RPS10/RPS29/RPS17/RPS8/MRPS16/RPS6/RPS3/RPL29/RPL5/RPL18/MRPL33/RPS15/RPL7/RPL22/RPSA/RPS16/RPS21/RPL22L1/RPS2/RPL6/MRPL9/RPS5/RPL3/MRPL22/RPL12/MRPL30/RPS28/FAU/MRPS15/MRPL23/MRPL10/RSL24D1/MRPL3/RPL38/RPL37/RPL27/RPS9/MRPS9/RPL31	63
KEGG	hsa05203	Viral carcinogenesis	82/3489	204/8135	0.8045	0.9297	0.671	EGR3/CCNE2/CREB3L2/PRKACB/SKP2/RBPJ/GRB2/CREB3/HRAS/CREB5/PMAIP1/POLB/YWHAZ/CCR5/CDKN2B/REL/CASP3/CDC20/STAT5A/TRAF5/CCNE1/GTF2H3/HLA-C/RHOA/DLG1/PXN/IL6ST/CREB3L1/USP7/GTF2H1/ACTN1/PRKACA/PIK3CD/CDK1/LYN/NFKB1/HDAC4/SYK/CHEK1/BAX/YWHAE/HLA-F/CCNA2/GTF2H2/HDAC3/CDK4/EP300/HLA-B/CCND2/PIK3R3/SRF/GTF2B/DNAJA3/MDM2/SP100/DDB1/RB1/GSN/HLA-G/GTF2H4/HLA-A/CDKN2A/ATF6B/HDAC1/IRF3/NFKBIA/CCR4/TRAF1/CREB3L4/CDKN1A/HNRNPK/STAT5B/HDAC8/HDAC2/IKBKG/MAPK1/GTF2E2/CDK6/JAK1/TRAF3/GTF2E1/TRADD	82
KEGG	hsa00030	Pentose phosphate pathway	11/3489	30/8135	0.8084	0.931	0.6719	PGM2/PRPS1/FBP1/GPI/PFKP/ALDOC/RGN/PGLS/GLYCTK/PGM1/PRPS2	11
KEGG	hsa00240	Pyrimidine metabolism	22/3489	58/8135	0.8152	0.9323	0.6729	ENTPD6/ENTPD3/TK2/NT5E/ENTPD1/NME1/TYMS/NME4/ENPP1/CANT1/ASMTL/UMPS/UCK2/RRM1/UCK1/UPP2/NME3/NT5M/HDDC2/DPYD/RRM2/RRM2B	22
KEGG	hsa00860	Porphyrin metabolism	16/3489	43/8135	0.8179	0.9323	0.6729	UGT1A6/MMAB/GUSB/BLVRA/BLVRB/UROD/COX10/HCCS/FXN/EARS2/PPOX/UGT2B17/UGT2B28/FECH/CP/HMOX1	16
KEGG	hsa04975	Fat digestion and absorption	16/3489	43/8135	0.8179	0.9323	0.6729	PLA2G3/ACAT2/AGPAT1/GOT2/PLA2G2A/DGAT2/ABCA1/SLC27A1/PLA2G2F/PLA2G2D/SCARB1/PLA2G12A/PLA2G1B/SLC27A4/DGAT1/AGPAT2	16
KEGG	hsa03013	Nucleocytoplasmic transport	42/3489	108/8135	0.8271	0.9386	0.6774	NUP205/NUP35/SEH1L/SNUPN/SUMO3/EIF4A3/NXF3/NUP155/NUP214/CSE1L/NUP50/NUP160/XPO4/XPO5/AAAS/RAN/NUP188/THOC7/MAGOH/NXT2/POM121/SEC13/MAGOHB/NXF2/NUP54/KPNA3/SAP18/UPF2/RAE1/IPO9/THOC2/XPOT/UPF3A/SUMO2/EEF1A2/SENP2/ACIN1/UPF1/RANGAP1/NUP107/CASC3/NUP37	42
KEGG	hsa00140	Steroid hormone biosynthesis	23/3489	61/8135	0.829	0.9386	0.6774	SULT2B1/UGT1A6/CYP3A5/CYP2E1/SRD5A1/SULT1E1/HSD17B2/HSD17B8/CYP3A4/CYP11A1/CYP1B1/HSD17B7/SRD5A3/CYP3A7/CYP21A2/CYP7B1/HSD17B3/HSD11B2/AKR1C3/DHRS11/UGT2B17/UGT2B28/HSD17B6	23
KEGG	hsa03050	Proteasome	17/3489	46/8135	0.8325	0.9393	0.6779	PSMD11/PSMD12/PSMD14/PSMB7/PSMB10/PSMB6/PSMF1/PSMD7/PSMD9/PSMB9/PSMC6/PSMD6/PSMC3/POMP/PSMD3/PSMD2/PSMC4	17
KEGG	hsa05017	Spinocerebellar ataxia	56/3489	143/8135	0.8399	0.9445	0.6817	RORA/PSMD11/SLC25A5/SPTBN2/SLC1A6/RBPJ/PLCB2/AKT3/KCND3/GNAQ/PSMD12/FGF14/PSMD14/PSMB7/RELN/AFG3L2/AKT1/ITPR3/PSMB6/XBP1/ATP2A3/PIK3CD/PSMD7/PSMD9/PPIF/CYCS/MTOR/MAPK8/VDAC1/ITPR1/PSMC6/RYR1/ATXN3/PIK3R3/GRIN2D/PRKCA/ITPR2/GTF2B/WIPI1/VLDLR/PIK3R4/RB1CC1/PSMD6/ERN1/DAB1/PRKCB/BECN1/PUM1/PSMC3/CIC/CACNA1A/PSMD3/TRPC3/PSMD2/GRIA2/PSMC4	56
KEGG	hsa03460	Fanconi anemia pathway	20/3489	54/8135	0.8437	0.9456	0.6825	FANCE/HES1/FANCI/PALB2/RAD51/MUS81/POLI/REV1/UBE2T/POLK/BRIP1/TOP3A/RPA1/ERCC1/MLH1/USP1/RAD51C/RMI1/EME2/BRCA1	20
KEGG	hsa03020	RNA polymerase	12/3489	34/8135	0.8581	0.9586	0.6918	POLR3E/POLR1C/POLR3F/POLR3GL/POLR1B/POLR1D/POLR3G/POLR2E/POLR3D/POLR2D/POLR3A/CD3EAP	12
KEGG	hsa04744	Phototransduction	10/3489	29/8135	0.8658	0.964	0.6957	CALML5/CALML3/CALM3/CNGA1/GUCA1C/GNB1/GUCA1A/SLC24A1/CALM2/RHO	10
KEGG	hsa02010	ABC transporters	16/3489	45/8135	0.8751	0.971	0.7008	ABCA12/ABCD3/DEFB1/ABCA8/ABCA1/ABCA5/ABCD1/CFTR/ABCD4/ABCG2/ABCA2/ABCB7/ABCA3/ABCC10/ABCA13/ABCA6	16
KEGG	hsa04976	Bile secretion	33/3489	89/8135	0.8896	0.9824	0.709	HMGCR/SLC5A1/UGT1A6/ATP1B1/NCEH1/SLC2A1/PRKACB/CA2/FXYD2/LDLR/CYP3A4/ATP1B3/ATP1A1/EPHX1/ADCY4/ADCY1/SLC4A2/CFTR/AQP1/GNAS/ADCY2/PRKACA/ABCG2/SCARB1/SCTR/ADCY8/ADCY9/ADCY6/SLC10A2/UGT2B17/ATP1B2/UGT2B28/SLC9A1	33
KEGG	hsa03018	RNA degradation	29/3489	79/8135	0.8912	0.9824	0.709	BTG3/ENO2/TOB1/NUDT16/PABPC1/MPHOSPH6/CNOT1/EXOSC6/EXOSC7/CNOT2/TTC37/CNOT6/HSPA9/DCP1B/LSM5/PABPC5/BTG1/PFKP/PABPC3/DHX36/EXOSC9/WDR61/CNOT10/PABPC1L2B/ENO3/PABPC4/BTG2/DIS3/EXOSC4	29
KEGG	hsa04932	Non-alcoholic fatty liver disease	59/3489	155/8135	0.905	0.9938	0.7172	CYP2E1/NR1H3/MAPK13/TGFB1/COX7B/ADIPOR1/AKT3/MAPK12/CASP3/FOS/PRKAG2/EIF2S1/SDHA/GSK3B/AKT1/BID/XBP1/FASLG/PIK3CD/DDIT3/NFKB1/UQCRC2/CYCS/MAPK11/ITCH/BAX/NDUFA7/MLXIP/MAPK8/COX6B2/COX7A1/MAP3K11/BCL2L11/NDUFV2/COX4I2/PIK3R3/TNFRSF1A/CEBPA/NDUFB9/COX5A/NDUFS7/IL6R/COX6C/NDUFB1/PRKAA1/ERN1/NDUFB4/COX7B2/MAPK14/NDUFC1/IRS2/NDUFA6/UQCRH/COX5B/UQCRFS1/PPARG/NDUFA12/NDUFA4L2/NDUFA9	59
KEGG	hsa04622	RIG-I-like receptor signaling pathway	25/3489	70/8135	0.9107	0.9938	0.7172	MAPK13/MAPK12/MAP3K7/ATG12/TRIM25/SIKE1/NFKB1/MAPK11/TBKBP1/IFNA1/MAPK8/IFIH1/ATG5/PIN1/NLRX1/RIPK1/IRF3/NFKBIA/FADD/MAP3K1/MAPK14/CASP10/IKBKG/TRAF3/TRADD	25
KEGG	hsa00513	Various types of N-glycan biosynthesis	13/3489	39/8135	0.9163	0.9938	0.7172	MAN1A1/HEXB/MGAT1/MGAT4A/HEXA/MGAT2/MAN1C1/FUT8/DAD1/MAN1B1/RPN2/ALG3/STT3A	13
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	86/3489	223/8135	0.9185	0.9938	0.7172	GSTO2/EPHX3/CYP2E1/GSTA3/NOX4/PLD1/MAP2K4/CYBA/CBR1/SLC25A5/MAPK13/HGF/GSTA4/GRB2/SLC26A9/BRAF/COX7B/HRAS/AKT3/MAPK12/ABL1/EPHX1/RAF1/PRKD1/AKR1A1/MAP2K1/EPHX2/FOS/CYP1B1/MGST2/ARNT/SDHA/NCF2/AKT1/GSTO1/PIK3CD/EGF/SLC26A1/PPIF/NFKB1/UQCRC2/MAPK11/PTPN1/NDUFA7/MGST3/MAPK8/GSTT2/COX6B2/EGFR/VDAC1/COX7A1/NDUFV2/COX4I2/ABL2/PIK3R3/NDUFB9/MAP3K14/COX5A/NDUFS7/GSTT1/COX6C/NFE2L2/NDUFB1/AKR1C3/SOD1/NFKBIA/NDUFB4/COX7B2/PRKD3/MAPK14/NDUFC1/EPHX4/NDUFA6/UQCRH/COX5B/UQCRFS1/PTPRJ/IKBKG/MAPK1/GSTM5/HMOX1/NDUFA12/NDUFA4L2/ARAF/NDUFA9/PTEN	86
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	40/3489	109/8135	0.9219	0.9938	0.7172	GAR1/NVL/EMG1/CSNK2A2/FBL/UTP15/EIF6/NHP2/GNL3/DKC1/RPP25/NXF3/HEATR1/WDR43/UTP14C/RPP40/GNL3L/RIOK1/WDR75/POP7/RPP38/REXO2/UTP18/WDR3/RAN/BMS1/NXT2/LSG1/NOP58/NXF2/CSNK2A1/CSNK2B/GNL2/RCL1/GTPBP4/MDN1/MPHOSPH10/RPP30/NAT10/NOP10	40
KEGG	hsa04623	Cytosolic DNA-sensing pathway	22/3489	63/8135	0.922	0.9938	0.7172	IL18/POLR3E/POLR1C/CCL5/POLR3F/POLR3GL/POLR1D/NFKB1/IFNA1/PYCARD/CCL4/POLR3G/RIPK1/POLR2E/IRF3/NFKBIA/POLR3D/IL33/POLR3A/ZBP1/RIPK3/IKBKG	22
KEGG	hsa00380	Tryptophan metabolism	14/3489	42/8135	0.9224	0.9938	0.7172	ACAT2/ALDH7A1/KMO/ALDH3A2/CYP1B1/AADAT/IDO2/ALDH8A1/ALDH1B1/AFMID/GCDH/ALDH2/ALDH9A1/DLD	14
KEGG	hsa05033	Nicotine addiction	13/3489	40/8135	0.9338	1	0.7217	GABRP/GABRB2/GABRR2/SLC17A7/GABRQ/GABRB1/GRIN2D/GABRE/CHRNA6/CACNA1A/GABRR1/SLC32A1/GRIA2	13
KEGG	hsa05020	Prion disease	103/3489	273/8135	0.9658	1	0.7217	TUBA4A/NCF4/C1QA/FYN/PSMD11/C1QB/C1QC/CREB3L2/CYBA/SLC25A5/CYBB/PRKACB/MAPK13/CSNK2A2/KLC3/CASP9/LAMC1/COX7B/TUBB2A/CREB3/CCL5/CREB5/HSPA6/MAPK12/RAC2/NCAM2/CASP3/PSMD12/PSMD14/PSMB7/EIF2S1/PPP3CC/TUBB3/SDHA/GSK3B/NCF2/ITPR3/CREB3L1/HSPA2/TUBB2B/PSMB6/PRKACA/APAF1/PIK3CD/CACNA1D/PSMD7/DDIT3/PSMD9/PPIF/UQCRC2/CYCS/MAPK11/BAX/NDUFA7/C9/EGR1/MAPK8/COX6B2/CAV1/VDAC1/ITPR1/COX7A1/NDUFV2/PSMC6/COX4I2/RYR1/PIK3R3/GRIN2D/KLC4/ITPR2/TUBA1A/NDUFB9/COX5A/NDUFS7/COX6C/NDUFB1/SOD1/TUBA3C/RYR3/ATF6B/PSMD6/TUBB1/NDUFB4/CSNK2A1/CSNK2B/COX7B2/C5/CREB3L4/MAPK14/NDUFC1/PSMC3/NDUFA6/UQCRH/COX5B/UQCRFS1/MAPK1/PSMD3/C6/NDUFA12/NDUFA4L2/NDUFA9/PSMD2/PSMC4	103
KEGG	hsa05010	Alzheimer disease	148/3489	384/8135	0.9658	1	0.7217	SLC39A2/IDE/TUBA4A/CALML5/WNT16/CALML3/APH1B/CALM3/CSNK1A1/NOX4/PSMD11/CSF1/WNT3/LRP1/CDK5R1/FZD6/DKK2/SLC25A5/CYBB/CSNK2A2/KLC3/FZD2/CASP9/BRAF/SLC39A6/WNT4/NAE1/COX7B/PLCB2/TUBB2A/HRAS/AKT3/FZD3/RAF1/GNAQ/CASP3/MAP2K1/PSMD12/PSMD14/PSMB7/EIF2S1/PPP3CC/TUBB3/MAPT/BACE1/SDHA/GSK3B/BACE2/AKT1/WNT5B/ITPR3/BID/TUBB2B/FZD4/PSMB6/XBP1/SLC39A7/ATP2A3/WNT5A/WNT2B/APAF1/PIK3CD/CACNA1D/PSMD7/SLC39A1/DDIT3/PSMD9/PPIF/CAPN2/NFKB1/MME/UQCRC2/APBB1/CYCS/MTOR/SLC39A8/NDUFA7/SLC11A2/FRAT1/MAPK8/NOS1/SLC39A4/COX6B2/WNT10A/VDAC1/ITPR1/COX7A1/NDUFV2/WNT7B/PSMC6/COX4I2/PIK3R3/TNFRSF1A/GRIN2D/APOE/KLC4/SLC39A13/ITPR2/TUBA1A/WIPI1/NDUFB9/CSNK1E/COX5A/NDUFS7/WNT7A/COX6C/NDUFB1/PIK3R4/RB1CC1/TUBA3C/RYR3/CHRM3/PSMD6/TUBB1/ADAM10/CHRM1/ERN1/FZD1/NDUFB4/CSNK2A1/FADD/CSNK2B/CALM2/COX7B2/BECN1/PSEN2/LRP5/NDUFC1/PSMC3/HSD17B10/WNT1/IRS2/NCSTN/NDUFA6/UQCRH/COX5B/UQCRFS1/IKBKG/LRP6/MAPK1/PSMD3/FZD8/NDUFA12/NDUFA4L2/ARAF/NDUFA9/PSMD2/PSMC4	148
KEGG	hsa04742	Taste transduction	29/3489	86/8135	0.9681	1	0.7217	SCNN1B/PDE1A/P2RY1/PRKACB/SCNN1G/GNB3/PLCB2/SCN9A/PDE1C/ADCY4/HTR3A/ITPR3/PRKACA/TAS2R10/TAS2R14/ADCY8/SCN2A/GABBR1/PKD2L1/KCNK5/GABBR2/ADCY6/CHRM3/ENTPD2/SCNN1A/HTR1A/TAS2R9/CACNA1A/TAS1R1	29
KEGG	hsa04950	Maturity onset diabetes of the young	7/3489	26/8135	0.9704	1	0.7217	HES1/HHEX/HNF1B/GCK/NR5A2/IAPP/FOXA2	7
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	183/3489	476/8135	0.981	1	0.7217	DNALI1/TUBA4A/CALML5/GPX2/WNT16/CALML3/CALM3/CSNK1A1/NOX4/DNAH3/PSMD11/CSF1/WNT3/GPX1/GPR37/GPX7/CDK5R1/FZD6/DKK2/SLC25A5/CYBB/MAPK13/GPX8/CSNK2A2/SPTBN2/TNFRSF1B/KLC3/FZD2/CASP9/BRAF/WNT4/COX7B/PLCB2/TUBB2A/HRAS/MAPK12/CCS/UBE2G1/SQSTM1/UBA7/FZD3/RAB5A/RAF1/GNAQ/CASP3/MAP2K1/MAP1LC3C/PSMD12/PSMD14/CHMP2B/UCHL1/PSMB7/EIF2S1/PPP3CC/DCTN3/TUBB3/MAPT/DLG4/SDHA/GSK3B/STX1A/WNT5B/ITPR3/BID/TUBB2B/FZD4/PSMB6/XBP1/ATP2A3/WNT5A/CAMK2A/FASLG/WNT2B/APAF1/CACNA1D/PSMD7/LRRK2/NEFH/DDIT3/PSMD9/PPIF/CAPN2/NFKB1/DNAL1/UQCRC2/HTRA2/MFN1/CYCS/MTOR/MAPK11/DNAL4/BAX/RAB1A/NDUFA7/VCP/DERL1/HIP1/FRAT1/MAPK8/NOS1/COX6B2/GPX3/WNT10A/DCTN5/VDAC1/ITPR1/COX7A1/NDUFV2/WNT7B/PSMC6/COX4I2/RYR1/ATXN3/PARK7/TNFRSF1A/GRIN2D/FIG4/PRKCA/KLC4/ALS2/ZFYVE1/ITPR2/TUBA1A/WIPI1/NDUFB9/CSNK1E/COX5A/NDUFS7/WNT7A/COX6C/NDUFB1/PIK3R4/DNAH6/RB1CC1/DNAH5/DCTN6/SOD1/TUBA3C/RYR3/CHRM3/PSMD6/TUBB1/CHRM1/PLCG1/ERN1/FZD1/NDUFB4/CSNK2A1/PRKCB/FADD/CSNK2B/CALM2/COX7B2/MFN2/BECN1/PSEN2/LRP5/MAPK14/NDUFC1/PSMC3/FUS/HSD17B10/WNT1/NDUFA6/UQCRH/COX5B/UQCRFS1/DNAH17/LRP6/MAPK1/PSMD3/TRPC3/BDNF/BCL2L1/FZD8/NDUFA12/NDUFA4L2/ACTR1A/ARAF/NDUFA9/PSMD2/GRIA2/PSMC4	183
KEGG	hsa05012	Parkinson disease	98/3489	266/8135	0.9822	1	0.7217	SLC39A2/TUBA4A/CALML5/CALML3/CALM3/PSMD11/GPR37/GNAI1/GNAI2/SLC25A5/PRKACB/KLC3/CASP9/SLC39A6/COX7B/TUBB2A/GNAI3/UBE2G1/UBA7/CASP3/PSMD12/PSMD14/UCHL1/PSMB7/EIF2S1/TUBB3/MAPT/SDHA/ITPR3/TUBB2B/PSMB6/XBP1/GNAS/SLC39A7/CAMK2A/PRKACA/APAF1/PSMD7/LRRK2/SLC39A1/DDIT3/TXN/PSMD9/PPIF/UQCRC2/HTRA2/MFN1/CYCS/DUSP1/SLC39A8/BAX/NDUFA7/SLC11A2/MAPK8/SLC39A4/COX6B2/VDAC1/ITPR1/COX7A1/NDUFV2/PSMC6/COX4I2/PARK7/SLC18A2/KLC4/SLC39A13/ITPR2/TUBA1A/NDUFB9/COX5A/NDUFS7/COX6C/NFE2L2/NDUFB1/SOD1/TUBA3C/RYR3/PSMD6/TUBB1/PLCG1/ERN1/NDUFB4/CALM2/COX7B2/MFN2/NDUFC1/PSMC3/NDUFA6/UQCRH/COX5B/UQCRFS1/PSMD3/BCL2L1/NDUFA12/NDUFA4L2/NDUFA9/PSMD2/PSMC4	98
KEGG	hsa05415	Diabetic cardiomyopathy	73/3489	203/8135	0.9824	1	0.7217	NCF4/GFPT2/SLC2A1/TGFBR2/CYBA/SLC25A5/CYBB/MAPK13/ACE/TGFB1/COX7B/PLCB2/PRKCZ/TNNI3/TGFB3/AKT3/MAPK12/RAC2/TGFBR1/SDHA/GSK3B/NCF2/TBC1D4/AKT1/AGT/ATP2A3/CAMK2A/GSR/PIK3CD/PPIF/NFKB1/UQCRC2/MTOR/MAPK11/CTSD/PPP1CB/TGFB2/NDUFA7/COL3A1/MAPK8/COX6B2/MMP9/VDAC1/MMP2/COX7A1/SMAD3/NDUFV2/COX4I2/PIK3R3/PRKCA/NDUFB9/COX5A/NDUFS7/COX6C/NDUFB1/COL1A2/GFPT1/NDUFB4/PARP1/PRKCB/COX7B2/AGTR1/MAPK14/NDUFC1/NDUFA6/UQCRH/COX5B/UQCRFS1/PDHB/NDUFA12/NDUFA4L2/NDUFA9/PTEN	73
KEGG	hsa04930	Type II diabetes mellitus	13/3489	46/8135	0.9862	1	0.7217	PRKCZ/HK3/GCK/PIK3CD/CACNA1D/MTOR/SOCS2/MAPK8/PIK3R3/IRS2/CACNA1A/MAPK1/HK1	13
KEGG	hsa04714	Thermogenesis	83/3489	232/8135	0.9894	1	0.7217	ACSL5/CREB3L2/PRKACB/MAPK13/RPS6KA2/GRB2/CPT1C/NDUFAF3/COX7B/CREB3/KDM3A/HRAS/CREB5/MAPK12/ACSL3/SMARCC1/COX16/RPS6KA6/ADCY4/PRKAG2/ADCY1/ZNF516/SMARCB1/ACSL4/SDHA/NPR1/CREB3L1/GNAS/COX17/COX10/ADCY2/PRKACA/FGFR1/SLC25A20/UQCRC2/RPS6/MTOR/COX11/MAPK11/NDUFA7/SMARCD3/COX6B2/PRKG1/ARID1B/ACTL6A/COX7A1/RPS6KB2/NDUFV2/COX4I2/ADCY8/PPARGC1A/MGLL/NDUFB9/COX5A/ADCY9/NDUFS7/KDM3B/PRKG2/PRDM16/ACSL6/COX6C/NDUFB1/PRKAA1/ADCY6/BMP8A/RPS6KB1/NDUFB4/COX7B2/CREB3L4/MAPK14/NDUFC1/ACSL1/COX18/NDUFA6/UQCRH/COX5B/UQCRFS1/PPARG/NPPA/NDUFA12/DPF1/NDUFA4L2/NDUFA9	83
KEGG	hsa00515	Mannose type O-glycan biosynthesis	5/3489	23/8135	0.9906	1	0.7217	FUT4/CHST10/FKRP/B3GALNT2/POMT1	5
KEGG	hsa04217	Necroptosis	54/3489	159/8135	0.9918	1	0.7217	CHMP4C/TLR4/FTH1/SLC25A5/CYBB/CHMP1B/PLA2G4F/FTL/STAT4/IFNAR2/CHMP4B/PLA2G4C/IFNAR1/SQSTM1/MLKL/TNFRSF10B/STAT5A/TRAF5/CHMP2B/PPIA/BID/PLA2G4D/CAMK2A/FASLG/GLUL/CHMP7/FAF1/CAPN2/NLRP3/TNFSF10/PYGM/ALOX15/BAX/IFNA1/PYCARD/MAPK8/VPS4B/VDAC1/SHARPIN/TNFRSF1A/RIPK1/PARP1/IL33/FADD/ZBP1/RIPK3/STAT5B/TYK2/SPATA2L/TLR3/RBCK1/PYGL/JAK1/TRADD	54
KEGG	hsa00190	Oxidative phosphorylation	44/3489	134/8135	0.9936	1	0.7217	ATP6V1C2/ATP6V0A4/COX7B/TCIRG1/ATP6V0E1/SDHA/PPA2/ATP12A/COX17/COX10/LHPP/UQCRC2/CYCS/ATP6AP1/COX11/NDUFA7/ATP6V0E2/ATP6V1C1/COX6B2/ATP6V1G1/ATP6V0A2/COX7A1/NDUFV2/COX4I2/ATP6V1B1/NDUFB9/COX5A/NDUFS7/COX6C/ATP6V0B/NDUFB1/PPA1/NDUFB4/COX7B2/NDUFC1/ATP6V1G2/NDUFA6/UQCRH/COX5B/UQCRFS1/ATP6V1A/NDUFA12/NDUFA4L2/NDUFA9	44
KEGG	hsa05014	Amyotrophic lateral sclerosis	131/3489	364/8135	0.9974	1	0.7217	DNALI1/TUBA4A/GPX2/DNAH3/PSMD11/GPX1/GPX7/PFN4/MAPK13/GPX8/TNFRSF1B/KLC3/NUP205/CASP9/NUP35/COX7B/TUBB2A/SEH1L/MAPK12/ANXA11/CCS/SQSTM1/NRG4/RAB5A/CASP3/NRG3/MAP1LC3C/PSMD12/HNRNPA1/PSMD14/CHMP2B/NXF3/PSMB7/EIF2S1/PPP3CC/DCTN3/TUBB3/NUP155/SDHA/NUP214/ITPR3/BID/TUBB2B/UBQLN4/PSMB6/XBP1/NUP50/PFN2/APAF1/PSMD7/NUP160/PFN1/NEFH/DDIT3/PSMD9/DNAL1/UQCRC2/CYCS/MTOR/MAPK11/DNAL4/BAX/RAB1A/NDUFA7/NRG1/VCP/DERL1/NOS1/COX6B2/NUP188/GPX3/NXT2/DCTN5/VDAC1/COX7A1/NDUFV2/POM121/PSMC6/COX4I2/SEC13/TNFRSF1A/GRIN2D/FIG4/NXF2/NUP54/KLC4/ALS2/TUBA1A/WIPI1/NDUFB9/COX5A/NDUFS7/COX6C/NDUFB1/PIK3R4/DNAH6/RAE1/RB1CC1/DNAH5/DCTN6/SOD1/TUBA3C/NRG2/PSMD6/TUBB1/ERN1/NDUFB4/ERBB4/COX7B2/BECN1/MAPK14/NDUFC1/PSMC3/FUS/NDUFA6/UQCRH/COX5B/UQCRFS1/DNAH17/PSMD3/NUP107/SETX/BCL2L1/NDUFA12/NDUFA4L2/ACTR1A/NDUFA9/PSMD2/NUP37/GRIA2/PSMC4	131
KEGG	hsa05016	Huntington disease	108/3489	306/8135	0.9976	1	0.7217	DNALI1/TUBA4A/GPX2/CLTB/DNAH3/PSMD11/AP2A2/GPX1/GPX7/CREB3L2/SLC25A5/GPX8/KLC3/RCOR1/CASP9/COX7B/PLCB2/TUBB2A/AP2B1/CREB3/CREB5/TAF4B/AP2M1/GNAQ/CASP3/PSMD12/TGM2/PSMD14/PSMB7/DCTN3/TUBB3/DLG4/SDHA/STX1A/CREB3L1/TFAM/TUBB2B/PSMB6/APAF1/PSMD7/PSMD9/PPIF/SIN3A/DNAL1/UQCRC2/CYCS/MTOR/DNAL4/BAX/NDUFA7/HIP1/MAPK8/COX6B2/GPX3/DCTN5/VDAC1/ITPR1/COX7A1/NDUFV2/EP300/PSMC6/COX4I2/PPARGC1A/KLC4/TUBA1A/WIPI1/NDUFB9/COX5A/NDUFS7/SLC1A3/COX6C/NDUFB1/PIK3R4/DNAH6/POLR2E/RB1CC1/DNAH5/DCTN6/SOD1/TUBA3C/PSMD6/TUBB1/HDAC1/ERN1/NDUFB4/POLR2D/COX7B2/BECN1/CREB3L4/NDUFC1/PSMC3/NDUFA6/UQCRH/HDAC2/COX5B/UQCRFS1/DNAH17/PSMD3/PPARG/TAF4/BDNF/NDUFA12/NDUFA4L2/ACTR1A/NDUFA9/PSMD2/GRIA2/PSMC4	108
KEGG	hsa05168	Herpes simplex virus 1 infection	177/3489	495/8135	0.9996	1	0.7217	POU2F3/ZNF57/SRPK1/HLA-DMA/ZFP82/ZNF689/ZNF334/ZNF285/ITGA5/HLA-DMB/ZNF275/ZNF610/ZNF177/ZNF793/ZNF273/PILRA/ZNF529/BST2/CASP9/ZNF546/TAPBP/ZNF333/ZNF641/ZNF780B/ZNF662/IFNAR2/ZNF565/CCL5/CFP/RNASEL/AKT3/IFNAR1/CD74/ZNF616/CASP3/ZNF780A/ZNF671/ZNF398/ZNF382/TRAF5/MAP3K7/ZNF214/NXF3/EIF2S1/ZNF621/ZNF559/ZNF564/HLA-C/ITGB3/ZNF721/ZNF347/TLR2/AKT1/ZNF440/BID/ZNF582/ZNF354C/ZNF569/ZNF783/ZNF169/FASLG/ZNF404/HLA-DRB1/APAF1/PIK3CD/ZNF337/ZNF430/ZNF182/ZNF200/ZNF786/ZNF189/ZNF132/ZNF100/HLA-DPA1/ZNF256/ZNF555/NFKB1/ZNF746/ZNF492/POU2F2/ZNF544/ZNF222/ZNF44/ZNF25/TNFRSF14/ZFP37/ZNF561/ZNF823/CYCS/MTOR/SYK/ZNF254/ZNF684/BAX/PPP1CB/ZNF267/ZNF585B/ZNF764/HLA-F/IFNA1/ZNF700/ZNF584/ZNF3/EIF2AK4/ZNF30/HLA-DOA/ZNF768/ZNF415/ZNF84/ZNF749/ZNF19/ZNF583/IFIH1/ZNF155/ZNF853/EIF4EBP1/ZNF461/HLA-DRA/ZNF302/HLA-B/ZNF77/PIK3R3/ZNF154/TNFRSF1A/ZNF701/NXF2/ZNF490/ZNF83/ZNF808/ZNF688/ZNF441/ZNF589/SP100/ZFP1/ZNF709/ZNF606/HLA-G/ZNF486/HLA-A/ZNF814/RBAK/ZNF630/ZNF682/IRF3/ZNF33A/NFKBIA/B2M/ZNF227/ZNF879/FADD/ZNF420/ZNF208/ZNF792/C5/EIF2B5/ZNF805/ZNF184/ZFP14/ZNF519/ZNF37A/ZNF226/ZNF615/ZNF320/ZNF416/TYK2/ZNF667/ZNF543/IKBKG/ZNF484/TLR3/ZNF93/ZNF785/ZNF250/BCL2L1/JAK1/TRAF3/TRADD	177
KEGG	hsa04080	Neuroactive ligand-receptor interaction	119/3489	353/8135	0.9999	1	0.7217	NMU/LYPD6B/SLURP1/PRSS3/F2RL1/LPAR3/PRSS2/LTB4R/FPR3/ADORA3/PTGER2/GABRP/TBXA2R/C3AR1/UCN2/P2RX4/S1PR3/HTR2A/F2RL2/P2RY6/CYSLTR1/APLNR/P2RY1/GABRB2/C5AR1/P2RY8/S1PR1/P2RY2/PTGER4/P2RX5/CALCRL/CHRNA9/PTGDR/LYNX1/LPAR4/F2R/GRM2/PARD3/GABRR2/GZMA/PENK/AVPR2/FPR1/OXTR/AGT/ADORA2B/UTS2/EDN3/HRH1/LPAR1/CHRNA3/THRB/CHRNA1/VIPR1/S1PR2/MCHR2/NPFF/INSL3/P2RY10/P2RX7/GABRQ/GABRB1/GLRB/PTGFR/SCTR/TAC3/NMB/PMCH/GALP/NPY1R/MTNR1A/P2RY13/TAAR5/GRIN2D/GH1/GABBR1/THRA/PTGIR/RLN2/IAPP/ADRB1/VIP/HTR7/GABBR2/GABRE/RXFP2/ADORA1/ADCYAP1/LHCGR/P2RY11/NR3C1/CHRM3/PTAFR/CHRM1/NPFFR1/LTB4R2/INSL5/HTR1A/CHRNE/C5/NPY/PLG/AGTR1/TAC1/S1PR4/GRM3/TACR1/TAAR8/CHRNA6/EDN1/PTH1R/GRM7/GABRR1/HCRT/PTGER1/CHRNA5/GPHA2/BDKRB2/GRIA2	119
KEGG	hsa04613	Neutrophil extracellular trap formation	57/3489	190/8135	0.9999	1	0.7217	TLR4/NCF4/FPR3/SELPLG/FCGR2A/ITGAM/TLR7/CYBA/SLC25A5/CYBB/ITGB2/MAPK13/SELP/TLR8/SIGLEC9/C5AR1/PLCB2/AKT3/MAPK12/RAC2/RAF1/CLCN3/MAP2K1/ITGAL/MAP3K7/VWF/GSDMD/FCGR1A/ITGB3/NCF2/TLR2/FPR1/AKT1/CLCN5/PIK3CD/PPIF/NFKB1/HDAC4/MTOR/SYK/MAPK11/CR1/HDAC3/VDAC1/PIK3R3/PRKCA/HDAC1/PLCG1/PRKCB/C5/MAPK14/ATG7/HDAC8/HDAC2/FGB/MAPK1/ITGA2B	57
KEGG	hsa05034	Alcoholism	52/3489	187/8135	1	1	0.7217	PKIA/CALML5/SLC29A3/CALML3/CALM3/GNAI1/GNAI2/GNG10/CREB3L2/PRKACB/GRB2/GNG2/BRAF/GNB3/CREB3/GNAI3/HRAS/CREB5/RAF1/GNG11/MAP2K1/FOSB/GNB4/GNG7/SHC3/CREB3L1/GNAS/ADORA2B/CAMKK2/PRKACA/SLC29A1/SHC1/SHC4/HDAC4/PPP1CB/GNB1/HDAC3/GNGT2/GNG5/GRIN2D/SLC18A2/ATF6B/HDAC1/CALM2/CAMKK1/CREB3L4/NPY/HDAC8/HDAC2/MAPK1/BDNF/ARAF	52
KEGG	hsa03040	Spliceosome	35/3489	147/8135	1	1	0.7217	SNRPA1/TRA2B/HSPA6/DHX15/EIF4A3/PRPF38A/HNRNPA1/DDX46/BCAS2/SNRPF/SNRPD3/HSPA2/SF3B3/CCDC12/LSM5/PPIH/CRNKL1/U2AF1L4/PHF5A/WBP11/MAGOH/SNRNP200/MAGOHB/PRPF40A/PPIL1/HNRNPM/PRPF4/SF3B2/PCBP1/THOC2/FUS/HNRNPK/ACIN1/RBM22/SNRNP40	35
KEGG	hsa05206	MicroRNAs in cancer	91/3489	310/8135	1	1	0.7217	FGFR3/SERPINB5/EFNA1/GLS2/EFNA3/EFNA4/ZEB2/ERBB3/WNT3/MIR214/PIM1/EZH2/CCNE2/ITGA5/DNMT3A/GRB2/VIM/EZR/PDCD4/MYC/HRAS/DNMT3B/TIMP3/NOTCH2/PDGFB/SLC7A1/BMF/ABL1/FZD3/RAF1/PDGFRA/CASP3/E2F3/MAP2K1/PDGFRB/CYP1B1/CCNE1/ITGB3/RHOA/ZEB1/PLAU/TNC/SOX4/ST14/PIK3CD/TP63/MIR101-1/NOTCH4/FOXP1/SHC1/NFKB1/SHC4/HDAC4/MTOR/ROCK1/TGFB2/MIR30C2/BCL2L2/MMP9/MDM4/KIF23/EGFR/PDGFA/BCL2L11/EP300/CCND2/STMN1/PIK3R3/RASSF1/PRKCA/MDM2/CYP24A1/CDKN2A/GLS/CDCA5/HDAC1/PLCG1/PRKCB/BMPR2/MIR21/HOXD10/CDKN1A/TPM1/IRS2/HNRNPK/HDAC2/MAPK1/BRCA1/HMOX1/CDK6/PTEN	91
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	7/3489	66/8135	1	1	0.7217	MARS2/FARSB/EARS2/QRSL1/PSTK/IARS2/NARS2	7
KEGG	hsa05322	Systemic lupus erythematosus	25/3489	136/8135	1	1	0.7217	HLA-DMA/C1QA/FCGR2A/C1QB/C2/C1QC/HLA-DMB/CD86/IL10/C1S/FCGR1A/CD40/SNRPD3/C1R/ACTN1/HLA-DRB1/HLA-DPA1/CD40LG/C9/HLA-DOA/HLA-DRA/SSB/CD28/C5/C6	25
KEGG	hsa04740	Olfactory transduction	28/3489	440/8135	1	1	0.7217	CALML5/CALML3/CALM3/ARRB1/SLC24A4/OR51E1/PDE1A/PRKACB/ARRB2/PDE1C/SLC8A1/PDE2A/GNG7/CAMK2A/PRKACA/GNB1/PRKG1/OR7A5/OR5P3/OR2C1/PRKG2/OR10A3/CALM2/OR2C3/OR10H3/OR52D1/OR10A4/SLC8A2	28