ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05146	Amoebiasis	29/1141	102/8135	0.0001048	0.03479	0.03133	RAB5C/FN1/ARG1/PIK3R1/ITGAM/LAMC1/CXCL3/PRKCA/TLR2/SERPINB10/RAB7A/IL10/PTK2/CXCL1/CXCL2/IL6/IL1R2/CD1C/TLR4/LAMC3/MUC2/COL4A1/SERPINB6/CD14/COL1A1/GNA15/COL3A1/COL1A2/CD1B	29
KEGG	hsa04380	Osteoclast differentiation	32/1141	128/8135	0.0006224	0.1033	0.09304	LILRA3/PPP3R1/TNFRSF11A/IFNGR1/PIK3R1/MAP2K6/IFNAR2/PPARG/FCGR1A/SOCS3/LILRA5/IFNGR2/LILRB4/MITF/LILRA6/IKBKB/BTK/SQSTM1/MAPK13/MAP3K14/BLNK/SIRPA/JUN/LILRA2/MAPK3/FCGR2A/LILRB5/TGFBR2/FHL2/CSF1/TAB2/LILRB2	32
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	20/1141	70/8135	0.001116	0.1055	0.09501	ATP6V0D1/CXCL3/ADAM10/PAK1/IKBKB/CXCL1/CXCL2/HBEGF/CDC42/NOD1/ADAM17/MAPK13/MAP3K14/TJP1/JUN/ATP6AP1/ATP6V1E1/PTPRZ1/ATP6V1B1/ATP6V0B	20
KEGG	hsa05150	Staphylococcus aureus infection	25/1141	96/8135	0.001271	0.1055	0.09501	C1QB/C1QC/HLA-DPB1/C1QA/FPR2/C3AR1/CFH/FPR1/CAMP/ITGAM/HLA-DMB/FCGR1A/HLA-DPA1/KRT10/IL10/DEFA4/HLA-DMA/KRT19/FCAR/C5/DEFB1/FCGR2A/KRT15/DEFA6/C1S	25
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	25/1141	100/8135	0.00235	0.156	0.1405	FN1/PIK3R1/THBD/PRKCA/PIM1/IL6/STAT5A/CDC42/NOS3/MAPK13/CCND1/VEGFC/COL4A1/SMAD3/BCL2/JUN/MAPK3/NRAS/COL1A1/AGTR1/TGFBR2/BAX/EDN1/COL3A1/COL1A2	25
KEGG	hsa05133	Pertussis	20/1141	76/8135	0.003284	0.1695	0.1526	C1QB/C1QC/C1QA/ITGAM/GNAI3/IL10/IL6/CALM3/NOD1/NLRP3/TLR4/RHOA/MAPK13/C5/CALML5/JUN/MAPK3/CD14/C1S/C4BPA	20
KEGG	hsa05221	Acute myeloid leukemia	18/1141	67/8135	0.004059	0.1695	0.1526	PIK3R1/ITGAM/FCGR1A/PIM1/IKBKB/STAT5A/JUP/RUNX1/CCNA1/PPARD/CCND1/MTOR/RUNX1T1/SOS1/MAPK3/NRAS/CD14/BCL2A1	18
KEGG	hsa04657	IL-17 signaling pathway	23/1141	94/8135	0.004595	0.1695	0.1526	LCN2/S100A9/CXCL3/IL17RA/IKBKB/CXCL1/CXCL2/IL6/IL17RC/CCL17/MAPK13/IL17B/JUN/MAPK3/MAPK4/TRAF5/CCL20/IL5/CEBPB/MAPK6/TAB2/PTGS2/MUC5AC	23
KEGG	hsa04218	Cellular senescence	34/1141	156/8135	0.005097	0.1695	0.1526	PPP3R1/ATR/PIK3R1/MAP2K6/HLA-G/HLA-B/ITPR2/IL6/E2F3/CALM3/RAD9A/SQSTM1/FOXM1/HIPK2/RHEB/E2F2/CDK6/HLA-C/MAPK13/CCNA1/RAD50/CCND1/MTOR/CALML5/SMAD3/CCNE2/MAPK3/NRAS/CCND2/TGFBR2/CCNB1/TSC1/LIN52/MYBL2	34
KEGG	hsa03450	Non-homologous end-joining	6/1141	13/8135	0.005336	0.1695	0.1526	PRKDC/DCLRE1C/RAD50/DNTT/NHEJ1/LIG4	6
KEGG	hsa04144	Endocytosis	50/1141	251/8135	0.005616	0.1695	0.1526	SH3GLB1/RAB5C/EHD2/HLA-G/TFRC/ARPC5/ARPC5L/ARF3/AGAP5/ZFYVE9/HLA-B/AMPH/FGFR3/RAB7A/CAV1/GRK1/RAB11FIP5/PLD1/RABEP1/PDCD6IP/CDC42/FOLR3/TSG101/ASAP1/CHMP4B/ARAP3/RHOA/VPS35/CHMP1A/RAB22A/HLA-C/EHD4/GBF1/ARAP1/SMAD3/DNM1/ACTR2/HSPA1A/PRKCI/ARF4/ARPC4/VPS36/IGF2R/EPN1/TGFBR2/PARD6B/RAB11B/PIP5K1A/PARD3/IGF1R	50
KEGG	hsa05222	Small cell lung cancer	22/1141	92/8135	0.007328	0.2027	0.1826	FN1/PIK3R1/LAMC1/IKBKB/PTK2/E2F3/E2F2/LAMC3/CDK6/CCND1/CKS1B/COL4A1/BCL2/CCNE2/TRAF5/BCL2L1/MAX/BAX/BAK1/APAF1/PTGS2/SKP2	22
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/1141	27/8135	0.008885	0.2166	0.195	B3GNT4/B3GNT5/B3GNT2/A4GALT/B3GALT1/B3GALNT1/FUT7/ABO/B4GALT1	9
KEGG	hsa05165	Human papillomavirus infection	62/1141	331/8135	0.009133	0.2166	0.195	ATR/FN1/FZD5/PIK3R1/IFNAR2/ATP6V0D1/HLA-G/LAMC1/COL6A1/HLA-B/ITGA10/HES2/ITGA7/IKBKB/PTK2/ITGA9/DLG2/CDC42/SLC9A3R1/PPP2R3A/APC2/RHEB/LAMC3/APC/CDK6/HLA-C/CCNA1/CCND1/CRB3/MTOR/COL6A6/SOS1/COL4A1/THBS4/HEYL/CCNE2/PXN/TNC/COL9A2/MAPK3/NRAS/PRKCI/CREB3L2/ATP6AP1/WNT1/ATP6V1E1/COL1A1/TUBG1/SCRIB/FZD2/TNN/CCND2/BAX/BAK1/TSC1/COL1A2/PTGS2/FZD4/ATP6V1B1/PARD6B/PARD3/ATP6V0B	62
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	44/1141	222/8135	0.009855	0.2181	0.1964	HLA-DPB1/ADCY3/PPP3R1/ATR/NRP1/PIK3R1/HLA-G/HLA-DMB/HLA-DPA1/POLB/TLN1/ETS2/HLA-B/IKBKB/IL6/STAT5A/E2F3/ANAPC1/IL1R2/HLA-DMA/E2F2/ANAPC7/HLA-C/CCNA1/CCND1/JAK3/LTBR/MAP3K14/TRRAP/SMAD3/MAD2L1/CCNE2/JUN/MAPK3/NRAS/FDPS/CREB3L2/VAC14/BCL2L1/CCND2/TGFBR2/BAX/SRF/TCF3	44
KEGG	hsa04145	Phagosome	32/1141	152/8135	0.01086	0.224	0.2017	HLA-DPB1/RAB5C/ATP6V0D1/ITGAM/HLA-G/TFRC/HLA-DMB/FCGR1A/HLA-DPA1/TLR2/MRC2/HLA-B/RAB7A/TUBB6/HLA-DMA/TLR4/MSR1/FCAR/HLA-C/THBS4/STX12/ATP6AP1/ATP6V1E1/CD14/FCGR2A/VAMP3/CLEC7A/TUBB2A/SEC61B/ATP6V1B1/COLEC12/ATP6V0B	32
KEGG	hsa04360	Axon guidance	37/1141	182/8135	0.01147	0.224	0.2017	UNC5B/PPP3R1/EPHB2/NRP1/PIK3R1/ROBO3/PRKCA/SEMA4G/ROCK1/SEMA4D/GNAI3/ROCK2/PLXNA3/NTNG1/SEMA3E/SRGAP1/PAK1/PTK2/PAK2/SEMA3C/SEMA3B/CAMK2G/CDC42/NTN3/CXCL12/SEMA6D/RHOA/SEMA6C/SEMA4B/EPHA8/SSH2/RGMA/SEMA5B/MAPK3/NRAS/PARD6B/PARD3	37
KEGG	hsa05214	Glioma	18/1141	75/8135	0.01391	0.2464	0.2219	PIK3R1/PRKCA/CAMK1D/E2F3/CAMK2G/CALM3/SHC3/E2F2/CDK6/CCND1/MTOR/CALML5/SOS1/MAPK3/NRAS/BAX/BAK1/IGF1R	18
KEGG	hsa05152	Tuberculosis	36/1141	180/8135	0.01603	0.2464	0.2219	HLA-DPB1/CTSD/PPP3R1/RAB5C/CAMP/IFNGR1/ATP6V0D1/ITGAM/HLA-DMB/FCGR1A/HLA-DPA1/TLR2/IFNGR2/CLEC4E/MRC2/RAB7A/IL10/IL6/CAMK2G/CALM3/HLA-DMA/TLR4/RHOA/MAPK13/CALML5/BCL2/MAPK3/ATP6AP1/CD14/FCGR2A/CLEC7A/BAX/APAF1/CEBPB/RFX5/ATP6V0B	36
KEGG	hsa04625	C-type lectin receptor signaling pathway	23/1141	104/8135	0.01608	0.2464	0.2219	PPP3R1/PIK3R1/CLEC4D/CCL22/CLEC4E/ITPR2/PAK1/IL10/IKBKB/IL6/CALM3/NLRP3/CCL17/RHOA/MAPK13/MAP3K14/CALML5/EGR3/JUN/MAPK3/NRAS/CLEC7A/PTGS2	23
KEGG	hsa05418	Fluid shear stress and atherosclerosis	29/1141	139/8135	0.0167	0.2464	0.2219	PIK3R1/MAP2K6/THBD/MGST1/SDC4/SDC2/MEF2A/SUMO1/IKBKB/CAV1/PTK2/CALM3/GPC1/IL1R2/GSTM4/SQSTM1/NOS3/RHOA/TXN/MAPK13/GSTM2/CALML5/BCL2/ASS1/JUN/GSTM1/EDN1/MAP2K5/DUSP1	29
KEGG	hsa04662	B cell receptor signaling pathway	19/1141	82/8135	0.01696	0.2464	0.2219	LILRA3/PPP3R1/PIK3R1/LILRA5/LILRB4/INPP5D/LILRA6/IKBKB/BTK/VAV1/SOS1/BLNK/JUN/LILRA2/DAPP1/MAPK3/NRAS/LILRB5/LILRB2	19
KEGG	hsa05205	Proteoglycans in cancer	40/1141	205/8135	0.01721	0.2464	0.2219	CD63/FN1/FZD5/PIK3R1/PRKCA/ROCK1/TLR2/SDC4/DDX5/ROCK2/ITPR2/SDC2/PAK1/CAV1/PTK2/CAMK2G/HBEGF/GPC1/VAV1/CDC42/TWIST1/TLR4/RHOA/TIMP3/MAPK13/CCND1/MTOR/LUM/DCN/SOS1/PXN/MAPK3/NRAS/WNT1/COL1A1/FZD2/HSPG2/COL1A2/FZD4/IGF1R	40
KEGG	hsa05168	Herpes simplex virus 1 infection	86/1141	495/8135	0.01781	0.2464	0.2219	HLA-DPB1/ZNF763/ZNF354B/ZFP90/ZNF780B/IFNGR1/PIK3R1/IFNAR2/ZNF823/ZNF205/HLA-G/ZNF573/ZNF337/PILRB/HLA-DMB/SOCS3/HLA-DPA1/TLR2/IFNGR2/ZNF490/ZNF182/ZNF404/ZNF175/ZNF560/ZNF846/HLA-B/ZNF200/ZNF343/ZNF543/ZNF248/IKBKB/ZNF555/ZNF585B/ZNF286A/IL6/ZNF879/HLA-DMA/ZNF41/ZNF420/ZNF324/RHEB/ZNF44/RBAK/ZFP14/ZNF230/HLA-C/MAVS/HCFC2/C5/ZNF439/ZNF782/ZNF425/ZNF84/ZNF234/MTOR/ZNF616/ZNF566/ZNF585A/ZNF33B/ZNF133/BCL2/ZNF700/POU2F3/ZNF226/ZNF417/TRAF5/ZFP30/BCL2L1/ZNF30/TNFRSF14/BAX/ZNF180/EIF2B5/BAK1/TSC1/ZNF177/APAF1/ZNF569/ZNF565/ZNF550/ZNF630/ZNF85/ZNF224/TAB2/ZNF641/ZNF570	86
KEGG	hsa04926	Relaxin signaling pathway	27/1141	129/8135	0.01963	0.2572	0.2316	ADCY3/EDNRB/PIK3R1/PRKCA/GNAI3/RXFP3/GNG5/SHC3/NOS3/GNG12/MAPK13/GNB1/VEGFC/SOS1/COL4A1/JUN/RLN3/MAPK3/NRAS/CREB3L2/COL1A1/TGFBR2/EDN1/GNA15/GNG11/COL3A1/COL1A2	27
KEGG	hsa04510	Focal adhesion	39/1141	201/8135	0.02014	0.2572	0.2316	FN1/PIK3R1/LAMC1/COL6A1/PRKCA/ROCK1/TLN1/ROCK2/ITGA10/PAK1/ITGA7/CAV1/PTK2/ITGA9/PAK2/VAV1/CDC42/SHC3/VASP/LAMC3/RHOA/CCND1/COL6A6/VEGFC/SOS1/COL4A1/THBS4/BCL2/PXN/JUN/TNC/COL9A2/MAPK3/COL1A1/TNN/CCND2/COL1A2/PIP5K1A/IGF1R	39
KEGG	hsa04722	Neurotrophin signaling pathway	25/1141	119/8135	0.02309	0.2694	0.2426	PIK3R1/SORT1/RPS6KA5/IKBKB/PSEN2/CAMK2G/CALM3/NTRK1/CDC42/ARHGDIA/SHC3/RHOA/MAPK13/ARHGDIG/CALML5/SOS1/SH2B3/BCL2/JUN/MAGED1/MAPK3/NRAS/NGF/BAX/MAP2K5	25
KEGG	hsa05134	Legionellosis	14/1141	57/8135	0.02322	0.2694	0.2426	ITGAM/CXCL3/TLR2/CXCL1/CXCL2/IL6/RAB1A/TLR4/SAR1A/HSPA1A/CD14/RAB1B/APAF1/SAR1B	14
KEGG	hsa05130	Pathogenic Escherichia coli infection	38/1141	197/8135	0.02354	0.2694	0.2426	GAPDH/ROCK1/CLDN14/ARPC5/CLDN5/ARPC5L/ROCK2/PAK1/IKBKB/TMBIM6/PAK2/TUBB6/IL6/CDC42/RAB1A/SLC9A3R1/NLRP3/TLR4/MYO1D/RHOA/MYH11/MAPK13/OCLN/ACTR2/TJP1/JUN/MAPK3/CLDN8/ARPC4/FCGR2A/TNFRSF10A/TUBB2A/CLDN3/BAX/BAK1/TMED10/WASF1/TAB2	38
KEGG	hsa04610	Complement and coagulation cascades	19/1141	85/8135	0.02435	0.2694	0.2426	C1QB/C1QC/C1QA/C3AR1/CFH/CLU/THBD/ITGAM/PROS1/CD55/KNG1/CD46/C5/SERPINB2/C1S/C4BPA/C6/F8/BDKRB2	19
KEGG	hsa04530	Tight junction	33/1141	169/8135	0.02826	0.3027	0.2725	ROCK1/CLDN14/SYMPK/ARPC5/CLDN5/ARPC5L/RAB13/ROCK2/DLG2/MYL6B/CD1C/CDC42/RUNX1/SLC9A3R1/VASP/RHOA/MYH11/OCLN/CCND1/AMOTL2/CRB3/ACTR2/TJP1/JUN/PRKCI/CLDN8/ARPC4/PCNA/SCRIB/CLDN3/CD1B/PARD6B/PARD3	33
KEGG	hsa05163	Human cytomegalovirus infection	42/1141	225/8135	0.02981	0.3093	0.2785	ADCY3/PPP3R1/PIK3R1/MAP2K6/HLA-G/PRKCA/ROCK1/PTGER2/GNAI3/ROCK2/HLA-B/ITPR2/IKBKB/PTK2/IL6/E2F3/CALM3/GNG5/CCR1/CXCL12/RHEB/E2F2/CDK6/RHOA/GNG12/HLA-C/MAPK13/GNB1/CCND1/MTOR/CALML5/SOS1/PXN/MAPK3/NRAS/CREB3L2/TRAF5/BAX/BAK1/TSC1/GNG11/PTGS2	42
KEGG	hsa05323	Rheumatoid arthritis	20/1141	93/8135	0.03132	0.3109	0.2799	HLA-DPB1/TNFRSF11A/ATP6V0D1/CXCL3/HLA-DMB/HLA-DPA1/TLR2/CXCL1/CXCL2/IL6/HLA-DMA/CXCL12/TLR4/JUN/ATP6AP1/ATP6V1E1/CCL20/CSF1/ATP6V1B1/ATP6V0B	20
KEGG	hsa05220	Chronic myeloid leukemia	17/1141	76/8135	0.03184	0.3109	0.2799	PIK3R1/IKBKB/STAT5A/E2F3/RUNX1/SHC3/E2F2/CDK6/CCND1/SOS1/SMAD3/MAPK3/NRAS/BCL2L1/TGFBR2/BAX/BAK1	17
KEGG	hsa04080	Neuroactive ligand-receptor interaction	62/1141	353/8135	0.03286	0.3117	0.2807	EDNRB/FPR2/C3AR1/GRM1/FPR1/CYSLTR2/TRPV1/PTGER2/GHRL/GALR2/UTS2/GLRA2/TAC3/GRP/DRD4/PRL/CRH/RXFP3/GPHA2/GH2/GRIK5/PRLR/P2RX4/CHRNE/KNG1/CHRNA9/HRH2/PTGFR/GALR3/TACR3/MCHR1/C5/PRSS2/DRD5/CSH1/GNRH1/NMUR2/PMCH/GABRB1/P2RX7/CHRNA4/HCRT/SLURP1/SCT/RLN3/NTSR1/GRIN1/EDN3/P2RY14/ADRA1B/AGTR1/MC2R/LTB4R2/EDN1/UCN3/SSTR5/TAAR1/MLNR/HTR7/BDKRB2/PARD3/VIPR2	62
KEGG	hsa04512	ECM-receptor interaction	19/1141	88/8135	0.03396	0.3132	0.282	FN1/LAMC1/GP1BB/COL6A1/SDC4/ITGA10/ITGA7/ITGA9/LAMC3/COL6A6/COL4A1/THBS4/TNC/COL9A2/COL1A1/HSPG2/TNN/COL1A2/GP9	19
KEGG	hsa05140	Leishmaniasis	17/1141	77/8135	0.03572	0.3167	0.2852	HLA-DPB1/IFNGR1/ITGAM/HLA-DMB/FCGR1A/HLA-DPA1/TLR2/IFNGR2/IL10/HLA-DMA/TLR4/MAPK13/JUN/MAPK3/FCGR2A/TAB2/PTGS2	17
KEGG	hsa04921	Oxytocin signaling pathway	30/1141	154/8135	0.03625	0.3167	0.2852	ADCY3/PPP3R1/RYR1/PRKCA/ROCK1/NPR1/GNAI3/ROCK2/ITPR2/CAMK1D/CACNG3/MYL6B/CAMK2G/CALM3/CACNA2D3/EEF2K/NOS3/PLA2G4C/RHOA/CCND1/CALML5/RYR2/CACNG2/NPPA/JUN/MAPK3/NRAS/EEF2/MAP2K5/PTGS2	30
KEGG	hsa04514	Cell adhesion molecules	29/1141	149/8135	0.0394	0.3196	0.2878	HLA-DPB1/ITGAM/HLA-G/HLA-DMB/HLA-DPA1/CLDN14/PDCD1LG2/CLDN5/SDC4/HLA-B/NTNG1/SDC2/NLGN2/ALCAM/ITGA9/NRCAM/HLA-DMA/CD34/CDH15/HLA-C/OCLN/MPZ/CLDN8/VCAN/CDH2/CD99/CLDN3/NRXN3/CD276	29
KEGG	hsa05226	Gastric cancer	29/1141	149/8135	0.0394	0.3196	0.2878	FZD5/PIK3R1/LRP5/FGF3/FGF6/FGF22/E2F3/JUP/SHC3/APC2/E2F2/APC/MUC2/CCND1/MTOR/SOS1/SMAD3/BCL2/CCNE2/MAPK3/NRAS/WNT1/FZD2/FGF4/CTNNA1/TGFBR2/BAX/BAK1/FZD4	29
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1141	24/8135	0.0416	0.3196	0.2878	HS6ST2/NDST1/NDST2/NDST3/GLCE/XYLT2/HS6ST1	7
KEGG	hsa05161	Hepatitis B	31/1141	162/8135	0.04184	0.3196	0.2878	PIK3R1/MAP2K6/PRKCA/TLR2/IKBKB/IL6/STAT5A/E2F3/TLR4/E2F2/MAVS/MAPK13/CCNA1/JAK3/SOS1/EGR3/SMAD3/BCL2/CCNE2/JUN/DDX3X/MAPK3/NRAS/CREB3L2/ATP6AP1/PCNA/HSPG2/TGFBR2/BAX/APAF1/TAB2	31
KEGG	hsa05202	Transcriptional misregulation in cancer	36/1141	193/8135	0.04226	0.3196	0.2878	HPGD/ITGAM/PPARG/FCGR1A/BCL6/MITF/DDX5/ETV6/PTK2/IL6/DEFA4/NUPR1/TFE3/IL1R2/NTRK1/JUP/RUNX1/CCNA1/TLX3/RUNX1T1/TAF15/CD14/BCL2L1/CCND2/BCL2A1/TGFBR2/ELANE/MAX/BAX/DEFA6/BAK1/CEBPB/TCF3/SMAD1/IGF1R/CCNT1	36
KEGG	hsa05170	Human immunodeficiency virus 1 infection	39/1141	212/8135	0.0431	0.3196	0.2878	PPP3R1/ATR/PIK3R1/MAP2K6/HLA-G/PRKCA/TLR2/GNAI3/HLA-B/ITPR2/PAK1/IKBKB/PTK2/APOBEC3B/PAK2/CALM3/AP1M2/GNG5/TLR4/GNG12/HLA-C/MAPK13/GNB1/MTOR/CALML5/APOBEC3A/BCL2/PXN/JUN/MAPK3/NRAS/TRAF5/BCL2L1/BAX/CCNB1/BAK1/AP1G2/GNG11/TAB2	39
KEGG	hsa04670	Leukocyte transendothelial migration	23/1141	114/8135	0.04332	0.3196	0.2878	PIK3R1/ITGAM/PRKCA/ROCK1/CLDN14/CLDN5/GNAI3/ROCK2/CTNND1/PTK2/VAV1/CDC42/CXCL12/VASP/RHOA/MAPK13/OCLN/THY1/PXN/CLDN8/CD99/CTNNA1/CLDN3	23
KEGG	hsa04070	Phosphatidylinositol signaling system	20/1141	97/8135	0.04664	0.3289	0.2962	PIK3R1/PRKCA/INPP5D/DGKG/ITPR2/SACM1L/DGKE/PPIP5K1/CALM3/IMPAD1/INPP4A/IP6K3/CALML5/INPP5F/PIK3C2B/OCRL/IMPA1/DGKI/MTMR2/PIP5K1A	20
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	20/1141	97/8135	0.04664	0.3289	0.2962	PIK3R1/FCGR1A/PRKCA/ARPC5/ARPC5L/INPP5D/AMPH/PAK1/PLD1/VAV1/CDC42/ASAP1/VASP/PLA2G4C/ACTR2/MAPK3/ARPC4/FCGR2A/WASF1/PIP5K1A	20
KEGG	hsa04151	PI3K-Akt signaling pathway	61/1141	354/8135	0.04755	0.3289	0.2962	AREG/FN1/PIK3R1/IFNAR2/LAMC1/COL6A1/PRKCA/TLR2/FGF3/FGFR3/ITGA10/ITGA7/PRL/IKBKB/PTK2/ITGA9/FGF6/IL6/FGF22/NTRK1/GNG5/PHLPP2/GH2/PRLR/GYS2/PPP2R3A/NOS3/RHEB/TLR4/LAMC3/CDK6/GNG12/CSH1/GNB1/CCND1/JAK3/MTOR/COL6A6/VEGFC/SOS1/COL4A1/THBS4/OSMR/BCL2/CCNE2/TNC/COL9A2/MAPK3/NRAS/CREB3L2/NGF/COL1A1/BCL2L1/FGF4/TNN/CCND2/TSC1/GNG11/COL1A2/CSF1/IGF1R	61
KEGG	hsa05210	Colorectal cancer	18/1141	86/8135	0.05023	0.3403	0.3064	AREG/PIK3R1/MSH2/APC2/APC/RHOA/CCND1/MTOR/SOS1/MSH6/SMAD3/BCL2/JUN/MAPK3/NRAS/TGFBR2/BAX/BAK1	18
KEGG	hsa05219	Bladder cancer	10/1141	41/8135	0.05282	0.3501	0.3153	DAPK3/RPS6KA5/FGFR3/RASSF1/E2F3/HBEGF/E2F2/CCND1/MAPK3/NRAS	10
KEGG	hsa01230	Biosynthesis of amino acids	16/1141	75/8135	0.05378	0.3501	0.3153	MTR/ARG1/GAPDH/PGK1/PSPH/PFKM/MAT2A/GLUL/MAT1A/ALDH18A1/BCAT1/PC/ALDOA/ASS1/ASNS/CTH	16
KEGG	hsa04640	Hematopoietic cell lineage	20/1141	99/8135	0.05605	0.3579	0.3222	HLA-DPB1/ITGAM/GP1BB/TFRC/HLA-DMB/FCGR1A/HLA-DPA1/CD55/CD24/IL6/IL1R2/CD1C/HLA-DMA/CD34/DNTT/CD14/IL5/GP9/CSF1/CD1B	20
KEGG	hsa04062	Chemokine signaling pathway	35/1141	192/8135	0.05931	0.3715	0.3345	ADCY3/PIK3R1/CXCL3/CCL22/ROCK1/PPBP/GNAI3/ROCK2/PAK1/IKBKB/GRK1/PTK2/CXCL1/CXCL2/VAV1/CDC42/GNG5/CCR1/SHC3/CXCL12/CCL17/RHOA/GNG12/GNB1/JAK3/PF4V1/SOS1/PXN/MAPK3/NRAS/CCL20/GNG11/CCL21/PARD3/CCL18	35
KEGG	hsa04668	TNF signaling pathway	22/1141	112/8135	0.06093	0.3746	0.3373	PIK3R1/MAP2K6/CXCL3/SOCS3/RPS6KA5/IKBKB/CXCL1/CXCL2/IL6/MAPK13/VEGFC/MAP3K14/JUN/MAPK3/CREB3L2/TRAF5/CCL20/EDN1/CSF1/CEBPB/TAB2/PTGS2	22
KEGG	hsa04370	VEGF signaling pathway	13/1141	59/8135	0.06205	0.3746	0.3373	PPP3R1/PIK3R1/PRKCA/PTK2/CDC42/NOS3/PLA2G4C/MAPK13/PXN/MAPK3/NRAS/MAPKAPK3/PTGS2	13
KEGG	hsa05216	Thyroid cancer	9/1141	37/8135	0.06533	0.3873	0.3488	PPARG/NTRK1/TPR/TPM3/CCND1/MAPK3/NRAS/BAX/BAK1	9
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	35/1141	194/8135	0.06703	0.3904	0.3515	PPP3R1/IFNGR1/PIK3R1/MAP2K6/IFNAR2/HLA-G/CXCL3/HLA-B/ITPR2/IKBKB/CXCL1/CXCL2/IL6/RPS27A/E2F3/CALM3/GNG5/CCR1/E2F2/CDK6/GNG12/HLA-C/MAPK13/GNB1/CCND1/MTOR/CALML5/JUN/MAP1LC3A/MAPK3/NRAS/BAX/BAK1/GNG11/PTGS2	35
KEGG	hsa05218	Melanoma	15/1141	72/8135	0.07199	0.4064	0.366	PIK3R1/FGF3/MITF/FGF6/FGF22/E2F3/E2F2/CDK6/CCND1/MAPK3/NRAS/FGF4/BAX/BAK1/IGF1R	15
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1141	49/8135	0.0733	0.4064	0.366	CHIT1/CYB5R3/HK2/CMAS/NAGK/PMM2/CYB5RL/PGM3/NPL/UAP1L1/CYB5R4	11
KEGG	hsa05169	Epstein-Barr virus infection	36/1141	202/8135	0.0739	0.4064	0.366	HLA-DPB1/PIK3R1/MAP2K6/IFNAR2/HLA-G/HLA-DMB/HLA-DPA1/TLR2/HLA-B/IKBKB/IL6/BTK/E2F3/PSMC3/HLA-DMA/E2F2/CDK6/HLA-C/MAVS/MAPK13/CCNA1/CCND1/JAK3/MAP3K14/BLNK/BCL2/CCNE2/JUN/TRAF5/CCND2/BAX/RUNX3/BAK1/APAF1/TAB2/SKP2	36
KEGG	hsa05330	Allograft rejection	9/1141	38/8135	0.07543	0.4064	0.366	HLA-DPB1/HLA-G/HLA-DMB/HLA-DPA1/HLA-B/IL10/HLA-DMA/HLA-C/IL5	9
KEGG	hsa04066	HIF-1 signaling pathway	21/1141	109/8135	0.07804	0.4064	0.366	IFNGR1/PIK3R1/GAPDH/TFRC/PRKCA/PGK1/HK2/IFNGR2/PFKM/IL6/CAMK2G/NOS3/TLR4/MTOR/LTBR/ALDOA/BCL2/NPPA/MAPK3/EDN1/IGF1R	21
KEGG	hsa00120	Primary bile acid biosynthesis	5/1141	17/8135	0.07813	0.4064	0.366	CH25H/CYP27A1/HSD3B7/ACOX2/ACOT8	5
KEGG	hsa01524	Platinum drug resistance	15/1141	73/8135	0.07941	0.4064	0.366	PIK3R1/MSH2/MGST1/REV3L/GSTM4/GSTM2/MSH6/BCL2/GSTM1/MAPK3/BCL2L1/BAX/BAK1/APAF1/TOP2A	15
KEGG	hsa00051	Fructose and mannose metabolism	8/1141	33/8135	0.08115	0.4064	0.366	ENOSF1/HK2/KHK/PFKM/FBP1/AKR1B10/PMM2/ALDOA	8
KEGG	hsa03410	Base excision repair	8/1141	33/8135	0.08115	0.4064	0.366	POLB/PARP2/UNG/NEIL2/MUTYH/PCNA/NEIL3/PARP4	8
KEGG	hsa05224	Breast cancer	27/1141	147/8135	0.08272	0.4064	0.366	FZD5/PIK3R1/LRP5/FGF3/FGF6/FGF22/E2F3/SHC3/APC2/E2F2/APC/CDK6/CCND1/MTOR/SOS1/DLL3/HEYL/JUN/MAPK3/NRAS/WNT1/FZD2/FGF4/BAX/BAK1/FZD4/IGF1R	27
KEGG	hsa04064	NF-kappa B signaling pathway	20/1141	104/8135	0.08521	0.4064	0.366	TNFRSF11A/CXCL3/IKBKB/CXCL1/CXCL2/BTK/CXCL12/TLR4/LTBR/MAP3K14/BLNK/BCL2/CD14/TRAF5/BCL2L1/BCL2A1/TRIM25/TAB2/PTGS2/CCL21	20
KEGG	hsa05231	Choline metabolism in cancer	19/1141	98/8135	0.086	0.4064	0.366	PIK3R1/PRKCA/DGKG/PLD1/DGKE/SLC22A5/RHEB/PLA2G4C/SLC44A2/MTOR/SOS1/JUN/MAPK3/NRAS/TSC1/CHPT1/DGKI/WASF1/PIP5K1A	19
KEGG	hsa00513	Various types of N-glycan biosynthesis	9/1141	39/8135	0.08644	0.4064	0.366	B4GALNT4/STT3B/B4GALNT3/RPN1/MAN1A1/MAN1C1/B4GALT1/CHST8/ALG13	9
KEGG	hsa04664	Fc epsilon RI signaling pathway	14/1141	68/8135	0.08691	0.4064	0.366	PIK3R1/MAP2K6/FCER1A/PRKCA/ALOX5AP/INPP5D/BTK/VAV1/PLA2G4C/MAPK13/SOS1/MAPK3/NRAS/IL5	14
KEGG	hsa04810	Regulation of actin cytoskeleton	38/1141	218/8135	0.08819	0.4066	0.3662	FN1/PIK3R1/ITGAM/ROCK1/ARPC5/ARPC5L/FGF3/ROCK2/FGFR3/ITGA10/PAK1/ITGA7/PTK2/ITGA9/PAK2/FGF6/FGF22/VAV1/CDC42/APC2/CXCL12/KNG1/APC/RHOA/GNG12/MYH11/FGD3/SSH2/SOS1/ACTR2/PXN/MAPK3/NRAS/ARPC4/FGF4/WASF1/BDKRB2/PIP5K1A	38
KEGG	hsa05225	Hepatocellular carcinoma	30/1141	168/8135	0.09409	0.4279	0.3853	FZD5/PIK3R1/PRKCA/LRP5/MGST1/E2F3/GSTM4/SHC3/APC2/E2F2/APC/CDK6/GSTM2/CCND1/MTOR/SMARCD2/SOS1/SMAD3/GSTM1/MAPK3/NRAS/WNT1/BCL2L1/FZD2/TGFBR2/BAX/SMARCC2/BAK1/FZD4/IGF1R	30
KEGG	hsa03320	PPAR signaling pathway	15/1141	75/8135	0.09568	0.4293	0.3865	APOA5/ME1/CPT1C/PPARG/FABP5/EHHADH/ACSL1/CYP27A1/PPARD/ACOX2/DBI/GK/FADS2/FABP1/SORBS1	15
KEGG	hsa05135	Yersinia infection	25/1141	137/8135	0.09778	0.4328	0.3897	FN1/PIK3R1/MAP2K6/ROCK1/ARPC5/ARPC5L/ROCK2/IL10/IKBKB/PTK2/IL6/VAV1/CDC42/NLRP3/TLR4/RHOA/MAPK13/ACTR2/PXN/JUN/MAPK3/ARPC4/FCGR2A/TAB2/PIP5K1A	25
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/1141	100/8135	0.1006	0.4339	0.3907	CXCL3/CCL22/PPBP/IL10/CXCL1/CXCL2/IL6/CCR1/CXCL12/CCL17/LTBR/PF4V1/TNFRSF10A/TNFRSF14/CCL20/CSF1/CCL21/CCL18/IL22RA1	19
KEGG	hsa04392	Hippo signaling pathway - multiple species	7/1141	29/8135	0.1013	0.4339	0.3907	DCHS1/PAK1/RASSF1/WWTR1/LIMD1/FRMD6/YAP1	7
KEGG	hsa04071	Sphingolipid signaling pathway	22/1141	119/8135	0.1033	0.4339	0.3907	CTSD/PIK3R1/FCER1A/PRKCA/ROCK1/DEGS2/GNAI3/ROCK2/PLD1/PPP2R3A/NOS3/KNG1/RHOA/MAPK13/SGMS1/BCL2/MAPK3/NRAS/SGPP2/BAX/SMPD1/BDKRB2	22
KEGG	hsa04935	Growth hormone synthesis, secretion and action	22/1141	119/8135	0.1033	0.4339	0.3907	ADCY3/PIK3R1/MAP2K6/SOCS3/PRKCA/GHRL/GNAI3/ITPR2/PTK2/STAT5A/GH2/SHC3/IGFALS/IRS4/MAPK13/CSH1/MTOR/SOS1/MAPK3/NRAS/CREB3L2/SSTR5	22
KEGG	hsa05212	Pancreatic cancer	15/1141	76/8135	0.1045	0.4339	0.3907	PIK3R1/IKBKB/PLD1/E2F3/CDC42/E2F2/CDK6/CCND1/MTOR/SMAD3/MAPK3/BCL2L1/TGFBR2/BAX/BAK1	15
KEGG	hsa04142	Lysosome	24/1141	132/8135	0.1064	0.436	0.3926	CD63/CTSD/GALC/AP3S2/SORT1/ATP6V0D1/GM2A/CTSA/CD68/AP1M2/SLC11A1/HYAL4/SLC17A5/CLN5/MANBA/MFSD8/ATP6AP1/CD164/IGF2R/SMPD1/AP1G2/SLC11A2/SCARB2/ATP6V0B	24
KEGG	hsa04152	AMPK signaling pathway	22/1141	120/8135	0.1105	0.4449	0.4007	ACACB/CPT1C/PIK3R1/PPARG/PFKM/FBP1/GYS2/PPP2R3A/EEF2K/RHEB/IRS4/CCNA1/CCND1/MTOR/HMGCR/CREB3L2/EEF2/ADIPOR1/RAB2A/TSC1/RAB11B/IGF1R	22
KEGG	hsa05100	Bacterial invasion of epithelial cells	15/1141	77/8135	0.1139	0.4449	0.4007	FN1/PIK3R1/ARPC5/ARPC5L/CAV1/PTK2/CDC42/SHC3/RHOA/DNM1/ACTR2/PXN/ARPC4/CTNNA1/WASF1	15
KEGG	hsa03013	Nucleocytoplasmic transport	20/1141	108/8135	0.1147	0.4449	0.4007	NUP205/UPF3B/CSE1L/XPO5/THOC1/IPO9/NUP214/SUMO1/TNPO3/MAGOH/NUP50/NUP35/TPR/IPO11/KPNA5/KPNB1/IPO13/NUP88/NXT2/NUP160	20
KEGG	hsa04659	Th17 cell differentiation	20/1141	108/8135	0.1147	0.4449	0.4007	HLA-DPB1/PPP3R1/IFNGR1/HLA-DMB/HLA-DPA1/IFNGR2/IL1RAP/IKBKB/IL6/STAT5A/HLA-DMA/RUNX1/MAPK13/JAK3/MTOR/SMAD3/JUN/MAPK3/EBI3/TGFBR2	20
KEGG	hsa05321	Inflammatory bowel disease	13/1141	65/8135	0.1153	0.4449	0.4007	HLA-DPB1/IFNGR1/HLA-DMB/HLA-DPA1/TLR2/IFNGR2/IL10/IL6/HLA-DMA/TLR4/SMAD3/JUN/IL5	13
KEGG	hsa05142	Chagas disease	19/1141	102/8135	0.1167	0.4452	0.4008	C1QB/C1QC/C1QA/IFNGR1/PIK3R1/TLR2/IFNGR2/GNAI3/IL10/IKBKB/IL6/KNG1/TLR4/MAPK13/JUN/MAPK3/TGFBR2/GNA15/BDKRB2	19
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1141	14/8135	0.1215	0.4548	0.4095	B3GNT2/CHST1/B4GALT1/ST3GAL2	4
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	8/1141	36/8135	0.1219	0.4548	0.4095	NMNAT2/QPRT/NNMT/NMNAT1/NMNAT3/AOX1/BST1/SIRT6	8
KEGG	hsa05223	Non-small cell lung cancer	14/1141	72/8135	0.1251	0.4576	0.412	PIK3R1/PRKCA/STAT5A/RASSF1/E2F3/E2F2/CDK6/CCND1/JAK3/SOS1/MAPK3/NRAS/BAX/BAK1	14
KEGG	hsa04140	Autophagy - animal	25/1141	141/8135	0.1254	0.4576	0.412	SH3GLB1/ATG12/CTSD/PIK3R1/RRAGD/DAPK3/RAB7A/SQSTM1/RAB1A/RHEB/IRS4/MTOR/ATG16L2/BCL2/MAP1LC3A/MAPK3/NRAS/BCL2L1/PIK3R4/SNAP29/ATG9B/ULK2/TSC1/ATG2B/IGF1R	25
KEGG	hsa04012	ErbB signaling pathway	16/1141	85/8135	0.132	0.4676	0.4211	AREG/PIK3R1/NRG1/PRKCA/PAK1/PTK2/PAK2/STAT5A/CAMK2G/HBEGF/SHC3/MTOR/SOS1/JUN/MAPK3/NRAS	16
KEGG	hsa05310	Asthma	7/1141	31/8135	0.1338	0.4676	0.4211	HLA-DPB1/FCER1A/HLA-DMB/HLA-DPA1/IL10/HLA-DMA/IL5	7
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1141	79/8135	0.134	0.4676	0.4211	PIK3R1/NRG1/PRKCA/FGFR3/IL6/GAS6/SHC3/MTOR/SOS1/BCL2/MAPK3/NRAS/BCL2L1/BAX/IGF1R	15
KEGG	hsa04020	Calcium signaling pathway	40/1141	240/8135	0.1361	0.4676	0.4211	ADCY3/EDNRB/GRM1/PPP3R1/CYSLTR2/RYR1/PRKCA/ASPH/FGF3/ITPR2/FGFR3/CAMK1D/FGF6/FGF22/CAMK2G/CALM3/NTRK1/PDE1A/CACNA1I/P2RX4/NOS3/HRH2/PTGFR/TACR3/DRD5/P2RX7/VEGFC/CALML5/RYR2/NTSR1/GRIN1/NGF/GDNF/FGF4/ADRA1B/AGTR1/LTB4R2/GNA15/HTR7/BDKRB2	40
KEGG	hsa01522	Endocrine resistance	18/1141	98/8135	0.1369	0.4676	0.4211	ADCY3/PIK3R1/PTK2/E2F3/HBEGF/SHC3/E2F2/MAPK13/CCND1/MTOR/SOS1/DLL3/BCL2/JUN/MAPK3/NRAS/BAX/IGF1R	18
KEGG	hsa00670	One carbon pool by folate	5/1141	20/8135	0.138	0.4676	0.4211	MTR/DHFR/MTHFD1L/ATIC/MTHFD1	5
KEGG	hsa00590	Arachidonic acid metabolism	12/1141	61/8135	0.1389	0.4676	0.4211	CYP2U1/AKR1C3/CYP4F2/LTC4S/PLA2G4C/ALOX15B/CYP4F8/GGT5/CYP4F3/PTGIS/PTGS2/PLA2G10	12
KEGG	hsa04672	Intestinal immune network for IgA production	10/1141	49/8135	0.14	0.4676	0.4211	HLA-DPB1/HLA-DMB/HLA-DPA1/IL10/IL6/HLA-DMA/CXCL12/LTBR/MAP3K14/IL5	10
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1141	143/8135	0.1409	0.4676	0.4211	ACVR1B/FZD5/PIK3R1/FGFR3/APC2/APC/MAPK13/LIFR/JAK3/ESRRB/SMAD9/SMAD3/TBX3/HOXA1/OTX1/MAPK3/NRAS/WNT1/FZD2/ID4/LHX5/TCF3/FZD4/SMAD1/IGF1R	25
KEGG	hsa04010	MAPK signaling pathway	48/1141	294/8135	0.1424	0.4681	0.4215	AREG/PPP3R1/MAP2K6/MAPK8IP3/MAP4K4/MAP4K1/PRKCA/FGF3/IL1RAP/RPS6KA5/FGFR3/PAK1/IKBKB/MAPK8IP1/PAK2/FGF6/CACNG3/FGF22/NTRK1/CDC42/CACNA1I/CACNA2D3/PLA2G4C/GNG12/MAPK8IP2/MAPK13/MAPT/VEGFC/MAP3K14/SOS1/PPP5C/CACNG2/JUN/HSPA1A/MAPK3/NRAS/CD14/NGF/FGF4/TGFBR2/MAX/MAP2K5/MAPKAPK3/SRF/CSF1/DUSP1/TAB2/IGF1R	48
KEGG	hsa05417	Lipid and atherosclerosis	36/1141	215/8135	0.1442	0.4692	0.4225	PPP3R1/PIK3R1/MAP2K6/PPARG/CXCL3/PRKCA/TLR2/ROCK2/IKBKB/PTK2/CXCL1/CXCL2/IL6/CAMK2G/CALM3/VAV1/CDC42/NLRP3/NOS3/TLR4/RHOA/MAPK13/CALML5/BCL2/JUN/POU2F3/HSPA1A/MAPK3/NRAS/CD14/BCL2L1/MIB1/TNFRSF10A/BAX/APAF1/TAB2	36
KEGG	hsa05145	Toxoplasmosis	20/1141	112/8135	0.1496	0.4746	0.4274	HLA-DPB1/IFNGR1/MAP2K6/LAMC1/HLA-DMB/HLA-DPA1/TLR2/IFNGR2/GNAI3/IL10/IKBKB/HLA-DMA/TLR4/LAMC3/MAPK13/BCL2/HSPA1A/MAPK3/BCL2L1/TAB2	20
KEGG	hsa04912	GnRH signaling pathway	17/1141	93/8135	0.1498	0.4746	0.4274	ADCY3/MAP2K6/PRKCA/ITPR2/PLD1/CAMK2G/HBEGF/CALM3/CDC42/PLA2G4C/MAPK13/GNRH1/CALML5/SOS1/JUN/MAPK3/NRAS	17
KEGG	hsa04215	Apoptosis - multiple species	7/1141	32/8135	0.1518	0.4746	0.4274	BIRC6/BCL2/HTRA2/BCL2L1/BAX/BAK1/APAF1	7
KEGG	hsa05110	Vibrio cholerae infection	10/1141	50/8135	0.1543	0.4746	0.4274	ADCY3/ATP6V0D1/PRKCA/SLC12A2/TJP1/ATP6AP1/ATP6V1E1/SEC61B/ATP6V1B1/ATP6V0B	10
KEGG	hsa04962	Vasopressin-regulated water reabsorption	9/1141	44/8135	0.1547	0.4746	0.4274	ADCY3/RAB5C/DCTN6/ARHGDIA/DYNC2LI1/ARHGDIG/DCTN4/CREB3L2/RAB11B	9
KEGG	hsa04015	Rap1 signaling pathway	35/1141	210/8135	0.1548	0.4746	0.4274	ADCY3/FPR1/PIK3R1/MAP2K6/ITGAM/PRKCA/TLN1/FGF3/GNAI3/CTNND1/FGFR3/FGF6/FGF22/CALM3/VAV1/CDC42/VASP/ARAP3/RHOA/MAPK13/SIPA1L2/VEGFC/CALML5/MAPK3/GRIN1/NRAS/PRKCI/NGF/FGF4/RGS14/CSF1/RAP1GAP/PARD6B/PARD3/IGF1R	35
KEGG	hsa04621	NOD-like receptor signaling pathway	31/1141	184/8135	0.1567	0.4746	0.4274	ATG12/TP53BP1/CAMP/IFNAR2/CXCL3/ITPR2/IKBKB/CXCL1/CXCL2/IL6/DEFA4/NOD1/NLRP3/TLR4/GBP4/RHOA/TXN/MAVS/MAPK13/P2RX7/BCL2/JUN/MAP1LC3A/MAPK3/GPRC6A/TRAF5/BCL2L1/ANTXR1/DEFA6/NLRP6/TAB2	31
KEGG	hsa05164	Influenza A	29/1141	171/8135	0.1572	0.4746	0.4274	HLA-DPB1/IFNGR1/PIK3R1/IFNAR2/HLA-DMB/SOCS3/HLA-DPA1/PRKCA/IFNGR2/IKBKB/IL6/HLA-DMA/TPSAB1/NLRP3/TLR4/CDK6/KPNA5/MAVS/PRSS2/MAPK3/FDPS/NXT2/TNFRSF10A/BAX/BAK1/APAF1/DNAJC3/TRIM25/RAB11B	29
KEGG	hsa05203	Viral carcinogenesis	34/1141	204/8135	0.1589	0.4753	0.428	PIK3R1/ATP6V0D1/HLA-G/POLB/HDAC8/HLA-B/STAT5A/CDC42/CDK6/RHOA/HLA-C/CCNA1/DNAJA3/CCND1/JAK3/LTBR/EGR3/HDAC9/CCNE2/PXN/JUN/DDX3X/MAPK3/NRAS/CREB3L2/VAC14/TRAF5/SCRIB/CCND2/BAX/BAK1/SRF/HPN/SKP2	34
KEGG	hsa04350	TGF-beta signaling pathway	17/1141	94/8135	0.1604	0.4754	0.428	ACVR1B/FBN1/ROCK1/ZFYVE9/LTBP1/RHOA/DCN/RGMA/SMAD9/SMAD3/THSD4/MAPK3/TGFBR2/BMP6/ID4/GREM1/SMAD1	17
KEGG	hsa04724	Glutamatergic synapse	20/1141	114/8135	0.1691	0.4952	0.4459	SLC1A3/ADCY3/GRM1/PPP3R1/PRKCA/GNAI3/HOMER3/ITPR2/PLD1/GLUL/GNG5/SHANK1/GRIK5/PLA2G4C/GNG12/GNB1/DLG4/MAPK3/GRIN1/GNG11	20
KEGG	hsa04014	Ras signaling pathway	38/1141	232/8135	0.17	0.4952	0.4459	RGL1/RAB5C/PIK3R1/PRKCA/FGF3/ETS2/FGFR3/PAK1/IKBKB/PLD1/PAK2/FGF6/FGF22/RASSF1/CALM3/NTRK1/CDC42/GNG5/SHC3/PLA2G4C/RHOA/GNG12/GNB1/RASAL3/VEGFC/CALML5/SOS1/MAPK3/GRIN1/NRAS/NGF/BCL2L1/FGF4/GNG11/CSF1/PLA2G10/HTR7/IGF1R	38
KEGG	hsa04917	Prolactin signaling pathway	13/1141	70/8135	0.175	0.5053	0.455	TNFRSF11A/PIK3R1/SOCS3/PRL/STAT5A/PRLR/SHC3/MAPK13/CCND1/SOS1/MAPK3/NRAS/CCND2	13
KEGG	hsa04310	Wnt signaling pathway	28/1141	167/8135	0.1781	0.5097	0.4589	SFRP4/PPP3R1/FZD5/PRKCA/LGR4/LRP5/ROCK2/CAMK2G/SFRP1/APC2/APC/RHOA/RSPO4/PPARD/CCND1/GPC4/TLE3/SMAD3/TLE6/SOST/JUN/WNT1/FZD2/DKK2/CCND2/CHD8/DKK4/FZD4	28
KEGG	hsa05131	Shigellosis	40/1141	247/8135	0.182	0.5164	0.465	ATG12/GLMN/PIK3R1/RRAGD/ROCK1/HK2/ARPC5/ARPC5L/TLN1/ROCK2/RPS6KA5/ITPR2/IKBKB/PTK2/RPS27A/CDC42/SQSTM1/NOD1/NLRP3/TLR4/RHOA/CAPNS1/UBE2N/MAPK13/MTOR/BCL2/ACTR2/PXN/JUN/MAP1LC3A/MAPK3/CD14/ARPC4/TRAF5/BCL2L1/PIK3R4/BAX/WASF1/TAB2/TECPR1	40
KEGG	hsa00900	Terpenoid backbone biosynthesis	5/1141	22/8135	0.1863	0.5199	0.4681	NUS1/PCYOX1/HMGCR/FDPS/ICMT	5
KEGG	hsa04520	Adherens junction	13/1141	71/8135	0.1885	0.5199	0.4681	CTNND1/PTPN1/CDC42/RHOA/SMAD3/TJP1/MAPK3/CTNNA1/TGFBR2/SORBS1/WASF1/PARD3/IGF1R	13
KEGG	hsa04974	Protein digestion and absorption	18/1141	103/8135	0.1892	0.5199	0.4681	COL6A1/COL16A1/SLC36A1/SLC15A1/COL17A1/SLC36A4/PRSS2/SLC9A3/COL14A1/CELA2B/COL6A6/COL4A1/COL9A2/COL5A2/COL1A1/COL3A1/COL1A2/CPA2	18
KEGG	hsa04060	Cytokine-cytokine receptor interaction	47/1141	295/8135	0.1895	0.5199	0.4681	ACVR1B/TNFRSF11A/IFNGR1/IFNAR2/CXCL3/CCL22/TNFRSF18/PPBP/IFNGR2/IL1RAP/IL17RA/PRL/IL10/CXCL1/CXCL2/IL6/IL1R2/IL17RC/GH2/PRLR/CCR1/CXCL12/CCL17/TNFRSF8/IL1RN/CNTFR/TNFRSF21/IL17B/LIFR/CSH1/LTBR/PF4V1/OSMR/NGF/TNFRSF10A/EBI3/TNFRSF14/TGFBR2/GDF2/CCL20/BMP6/IL5/CSF1/CLCF1/CCL21/CCL18/IL22RA1	47
KEGG	hsa05132	Salmonella infection	40/1141	249/8135	0.1965	0.5347	0.4815	RAB5C/MAP2K6/KLC4/GAPDH/CSE1L/ARPC5/ARPC5L/TLR2/ROCK2/DCTN6/RAB7A/PAK1/IKBKB/TUBB6/IL6/CDC42/NOD1/NLRP3/TLR4/RHOA/TXN/MAPK13/DYNC2LI1/DCTN3/BCL2/ACTR2/SNX33/DCTN4/JUN/MAPK3/S100A10/CD14/ARPC4/TNFRSF10A/PIK3C2B/TUBB2A/BAX/BAK1/ACTR1A/TAB2	40
KEGG	hsa04611	Platelet activation	21/1141	124/8135	0.2059	0.5496	0.4949	ADCY3/PIK3R1/GP1BB/ROCK1/TLN1/GNAI3/ROCK2/ITPR2/BTK/NOS3/VASP/PLA2G4C/RHOA/MAPK13/MAPK3/PRKCI/COL1A1/FCGR2A/COL3A1/COL1A2/GP9	21
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	17/1141	98/8135	0.2065	0.5496	0.4949	ADCY3/PIK3R1/MAP2K6/TRPV1/PRKCA/PTGER2/IL1RAP/ITPR2/CAMK2G/CALM3/NTRK1/KNG1/PLA2G4C/MAPK13/CALML5/NGF/BDKRB2	17
KEGG	hsa04390	Hippo signaling pathway	26/1141	157/8135	0.2069	0.5496	0.4949	AREG/FZD5/DLG5/DLG2/RASSF1/WWTR1/APC2/APC/LIMD1/FRMD6/CCND1/DLG4/SMAD3/PRKCI/WNT1/SCRIB/FZD2/CCND2/CTNNA1/TGFBR2/BMP6/YAP1/FZD4/PARD6B/SMAD1/PARD3	26
KEGG	hsa04068	FoxO signaling pathway	22/1141	131/8135	0.2106	0.5525	0.4975	ATG12/GRM1/PIK3R1/BCL6/HOMER3/IL10/IKBKB/IL6/CDKN2D/IRS4/MAPK13/CCND1/PLK2/SOS1/SMAD3/MAPK3/NRAS/CCND2/TGFBR2/CCNB1/IGF1R/SKP2	22
KEGG	hsa04658	Th1 and Th2 cell differentiation	16/1141	92/8135	0.2124	0.5525	0.4975	HLA-DPB1/PPP3R1/IFNGR1/HLA-DMB/HLA-DPA1/IFNGR2/IKBKB/STAT5A/HLA-DMA/MAPK13/JAK3/DLL3/JUN/MAPK3/RUNX3/IL5	16
KEGG	hsa05416	Viral myocarditis	11/1141	60/8135	0.213	0.5525	0.4975	HLA-DPB1/HLA-G/HLA-DMB/HLA-DPA1/CD55/HLA-B/CAV1/HLA-DMA/HLA-C/CCND1/EIF4G3	11
KEGG	hsa04915	Estrogen signaling pathway	23/1141	138/8135	0.215	0.5535	0.4984	ADCY3/GRM1/CTSD/PIK3R1/FKBP5/GNAI3/NCOA2/KRT10/ITPR2/HBEGF/CALM3/SHC3/NOS3/KRT19/CALML5/SOS1/BCL2/JUN/HSPA1A/MAPK3/NRAS/CREB3L2/KRT15	23
KEGG	hsa03460	Fanconi anemia pathway	10/1141	54/8135	0.2183	0.5576	0.5021	ATR/REV3L/FANCE/FANCG/TOP3A/FANCF/TELO2/FANCL/ERCC4/FANCD2	10
KEGG	hsa05332	Graft-versus-host disease	8/1141	42/8135	0.2287	0.5768	0.5194	HLA-DPB1/HLA-G/HLA-DMB/HLA-DPA1/HLA-B/IL6/HLA-DMA/HLA-C	8
KEGG	hsa00561	Glycerolipid metabolism	11/1141	61/8135	0.2293	0.5768	0.5194	AGPAT2/DGKG/AKR1A1/DGKE/MBOAT2/AKR1B10/GK/AGPAT5/PNPLA2/GPAM/DGKI	11
KEGG	hsa00500	Starch and sucrose metabolism	7/1141	36/8135	0.2334	0.5782	0.5207	HK2/AGL/GBA3/GYS2/PYGB/MGAM/GYG1	7
KEGG	hsa03030	DNA replication	7/1141	36/8135	0.2334	0.5782	0.5207	RNASEH2B/POLA1/MCM7/PRIM1/PCNA/MCM3/RNASEH2A	7
KEGG	hsa01523	Antifolate resistance	6/1141	30/8135	0.2373	0.5836	0.5255	IKBKB/DHFR/IL6/FOLR3/ABCC5/ATIC	6
KEGG	hsa04024	cAMP signaling pathway	35/1141	221/8135	0.2421	0.5909	0.5321	ADCY3/PIK3R1/ROCK1/PTGER2/GHRL/FFAR2/NPR1/GNAI3/ROCK2/PAK1/PLD1/CRH/CAMK2G/CALM3/GPHA2/VAV1/CNGB3/ARAP3/RHOA/DRD5/HCN2/CALML5/RYR2/NPPA/JUN/MAPK3/GRIN1/EDN3/CREB3L2/PPP1R1B/HCN4/MC2R/EDN1/SSTR5/VIPR2	35
KEGG	hsa04916	Melanogenesis	17/1141	101/8135	0.2446	0.5912	0.5323	ADCY3/EDNRB/FZD5/PRKCA/MITF/GNAI3/TYR/CAMK2G/CALM3/CALML5/MAPK3/NRAS/CREB3L2/WNT1/FZD2/EDN1/FZD4	17
KEGG	hsa04940	Type I diabetes mellitus	8/1141	43/8135	0.2491	0.5912	0.5323	HLA-DPB1/CPE/HLA-G/HLA-DMB/HLA-DPA1/HLA-B/HLA-DMA/HLA-C	8
KEGG	hsa04072	Phospholipase D signaling pathway	24/1141	148/8135	0.2512	0.5912	0.5323	ADCY3/GRM1/PIK3R1/FCER1A/PRKCA/AGPAT2/DGKG/PLD1/DGKE/SHC3/RHEB/PLA2G4C/RHOA/PTGFR/MTOR/SOS1/DNM1/MAPK3/NRAS/AGPAT5/AGTR1/TSC1/DGKI/PIP5K1A	24
KEGG	hsa04934	Cushing syndrome	25/1141	155/8135	0.2545	0.5912	0.5323	ADCY3/FZD5/GNAI3/ITPR2/CRH/E2F3/CAMK2G/CACNA1I/APC2/E2F2/APC/CDK6/WDR5B/ARMC5/CCND1/KCNK3/CCNE2/MAPK3/CREB3L2/WNT1/FZD2/AGTR1/MC2R/CYP11A1/FZD4	25
KEGG	hsa04924	Renin secretion	12/1141	69/8135	0.255	0.5912	0.5323	PPP3R1/PTGER2/NPR1/GNAI3/ITPR2/CALM3/PDE1A/CALML5/NPPA/EDN3/AGTR1/EDN1	12
KEGG	hsa05143	African trypanosomiasis	7/1141	37/8135	0.2558	0.5912	0.5323	HBB/PRKCA/IL10/IL6/KNG1/HPR/NPPA	7
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	72/1141	476/8135	0.2569	0.5912	0.5323	GRM1/PPP3R1/UBE2J1/NDUFA4L2/FZD5/MAP2K6/KLC4/RYR1/PRKCA/LRP5/NDUFA12/DNAH5/DCTN6/ITPR2/COX5A/TUBB6/IL6/RPS27A/PSEN2/ATXN2/CAMK2G/CALM3/PSMC3/SQSTM1/RAB1A/COX6B2/APC2/DNAH10/APC/MAPK13/MAPT/DCTN3/DNAH11/TRAP1/COX7A1/MTOR/PSMD9/DLG4/CALML5/RYR2/PSMA6/BCL2/ATXN1/HTRA2/DCTN4/NDUFB2/MAP1LC3A/NEFH/MAPK3/GRIN1/NRAS/WNT1/PSMB6/BCL2L1/FZD2/PIK3R4/DKK2/TUBB2A/BAX/ATXN1L/DKK4/BAK1/ULK2/APAF1/ATG2B/SPTBN2/NDUFB6/CSF1/NDUFB9/ACTR1A/PTGS2/FZD4	72
KEGG	hsa04630	JAK-STAT signaling pathway	26/1141	162/8135	0.2577	0.5912	0.5323	IFNGR1/PIK3R1/IFNAR2/SOCS3/PIM1/IFNGR2/PRL/IL10/IL6/STAT5A/GH2/PRLR/CNTFR/LIFR/CSH1/CCND1/JAK3/MTOR/AOX1/SOS1/OSMR/BCL2/BCL2L1/CCND2/IL5/IL22RA1	26
KEGG	hsa04936	Alcoholic liver disease	23/1141	142/8135	0.2589	0.5912	0.5323	C1QB/C1QC/C1QA/ACACB/C3AR1/CPT1C/MAP2K6/CXCL3/IL17RA/IKBKB/CXCL1/CXCL2/IL6/IL17RC/TLR4/MAPK13/C5/CCND1/MAP3K14/CD14/FABP1/ADIPOR1/TAB2	23
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1141	89/8135	0.2607	0.5912	0.5323	PPP3R1/IFNGR1/PIK3R1/MAP2K6/TLR2/IFNGR2/IKBKB/BATF/TLR4/MAPK13/MTOR/JUN/MAPK3/NRAS/BATF3	15
KEGG	hsa00510	N-Glycan biosynthesis	9/1141	50/8135	0.2617	0.5912	0.5323	STT3B/DPM1/RPN1/MAN1A1/MAN1C1/DOLK/B4GALT1/SRD5A3/ALG13	9
KEGG	hsa04150	mTOR signaling pathway	25/1141	156/8135	0.2654	0.5955	0.5362	FZD5/PIK3R1/RRAGD/PRKCA/LRP5/IKBKB/GRB10/RHEB/RHOA/NPRL2/SLC38A9/TELO2/MTOR/SOS1/MAPK3/NRAS/WNT1/ATP6V1E1/FZD2/ULK2/TSC1/FZD4/ATP6V1B1/IGF1R/SKP2	25
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	24/1141	150/8135	0.2736	0.6096	0.5489	ADCY3/PRKCA/GNAI3/RPS6KA5/TPM1/CACNG3/CAMK2G/CALM3/CACNA2D3/PPP2R3A/KCNE1/TPM4/TPM3/MAPK13/CALML5/RYR2/BCL2/CACNG2/SCN1B/MAPK3/CREB3L2/ADRA1B/AGTR1/TNNT2	24
KEGG	hsa05340	Primary immunodeficiency	7/1141	38/8135	0.2787	0.6169	0.5555	BTK/IGLL1/UNG/DCLRE1C/JAK3/BLNK/RFX5	7
KEGG	hsa04713	Circadian entrainment	16/1141	97/8135	0.2806	0.617	0.5556	ADCY3/RYR1/PRKCA/GNAI3/RPS6KA5/CAMK2G/CALM3/CACNA1I/GNG5/GNG12/GNB1/CALML5/RYR2/MAPK3/GRIN1/GNG11	16
KEGG	hsa04136	Autophagy - other	6/1141	32/8135	0.2876	0.6282	0.5657	ATG12/MTOR/PIK3R4/ATG9B/ULK2/ATG2B	6
KEGG	hsa05213	Endometrial cancer	10/1141	58/8135	0.291	0.6314	0.5685	PIK3R1/APC2/APC/CCND1/SOS1/MAPK3/NRAS/CTNNA1/BAX/BAK1	10
KEGG	hsa04925	Aldosterone synthesis and secretion	16/1141	98/8135	0.2951	0.6353	0.5721	ADCY3/PRKCA/NPR1/ITPR2/CAMK1D/CAMK2G/CALM3/CACNA1I/KCNK3/CALML5/NPPA/CREB3L2/AGTR1/MC2R/CYP11A1/KCNK9	16
KEGG	hsa00790	Folate biosynthesis	5/1141	26/8135	0.2966	0.6353	0.5721	AKR1C3/DHFR/PCBD2/AKR1B10/QDPR	5
KEGG	hsa05162	Measles	22/1141	139/8135	0.3032	0.6453	0.5811	PIK3R1/IFNAR2/TLR2/IKBKB/IL6/STAT5A/TLR4/CDK6/CD46/MAVS/CCND1/JAK3/BCL2/CCNE2/JUN/HSPA1A/BCL2L1/CCND2/BAX/BAK1/APAF1/TAB2	22
KEGG	hsa04110	Cell cycle	20/1141	126/8135	0.3101	0.6557	0.5904	ATR/E2F3/ANAPC1/CDKN2D/PRKDC/E2F2/MCM7/CDK6/ANAPC7/CCNA1/CCND1/SMAD3/MAD2L1/CCNE2/PCNA/CCND2/CCNB1/MCM3/CDC7/SKP2	20
KEGG	hsa05320	Autoimmune thyroid disease	9/1141	53/8135	0.3223	0.6745	0.6073	HLA-DPB1/HLA-G/HLA-DMB/HLA-DPA1/HLA-B/IL10/HLA-DMA/HLA-C/IL5	9
KEGG	hsa04115	p53 signaling pathway	12/1141	73/8135	0.323	0.6745	0.6073	ATR/CD82/CDK6/CCND1/BCL2/CCNE2/BCL2L1/TNFRSF10A/CCND2/BAX/CCNB1/APAF1	12
KEGG	hsa00260	Glycine, serine and threonine metabolism	7/1141	40/8135	0.326	0.6764	0.6091	MAOA/PSPH/ALAS2/GNMT/GCAT/SARDH/CTH	7
KEGG	hsa04730	Long-term depression	10/1141	60/8135	0.3295	0.6795	0.6119	GRM1/RYR1/PRKCA/GNAI3/ITPR2/CRH/PLA2G4C/MAPK3/NRAS/IGF1R	10
KEGG	hsa04726	Serotonergic synapse	18/1141	115/8135	0.3455	0.708	0.6375	SLC18A1/PRKCA/MAOA/GNAI3/ITPR2/HTR3C/GNG5/PLA2G4C/GNG12/ALOX15B/GNB1/GABRB1/MAPK3/NRAS/GNG11/DUSP1/PTGS2/HTR7	18
KEGG	hsa04540	Gap junction	14/1141	88/8135	0.3488	0.7087	0.6382	ADCY3/GRM1/PRKCA/GNAI3/ITPR2/TUBB6/GJA1/SOS1/TJP1/MAPK3/NRAS/TUBB2A/MAP2K5/GJD2	14
KEGG	hsa04216	Ferroptosis	7/1141	41/8135	0.3501	0.7087	0.6382	TFRC/ACSL1/SLC39A8/MAP1LC3A/SAT2/PCBP1/SLC11A2	7
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1141	15/8135	0.3531	0.7087	0.6382	A4GALT/B3GALNT1/ST3GAL2	3
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	32/1141	212/8135	0.3544	0.7087	0.6382	KLF5/ADCY3/PIK3R1/PRKCA/BCL6/MGST1/FGF3/GNAI3/FGF6/FGF22/STAT5A/PAQR8/GSTM4/CHRNA9/KPNA5/GSTM2/CCND1/MTOR/CHRNA4/EPHX3/SOS1/KPNB1/DLL3/BCL2/JUN/GSTM1/MAPK3/NRAS/CREB3L2/WNT1/FGF4/CYP1B1	32
KEGG	hsa04141	Protein processing in endoplasmic reticulum	26/1141	171/8135	0.3595	0.7146	0.6435	HSPH1/UBE2J1/STT3B/CKAP4/UGGT2/RPN1/DNAJC5/MAN1A1/DNAJB11/LMAN1L/MAN1C1/DNAJC10/RNF185/SAR1A/BCL2/HSPA1A/P4HB/SEC31B/BAX/AMFR/BAK1/SEC61B/DNAJC3/SAR1B/RAD23B/UBQLN4	26
KEGG	hsa04910	Insulin signaling pathway	21/1141	137/8135	0.3653	0.7218	0.65	ACACB/PIK3R1/SOCS3/HK2/PTPN1/IKBKB/CALM3/FBP1/GYS2/SHC3/PYGB/RHEB/IRS4/MTOR/CALML5/SOS1/MAPK3/NRAS/PRKCI/TSC1/SORBS1	21
KEGG	hsa00220	Arginine biosynthesis	4/1141	22/8135	0.373	0.7286	0.656	ARG1/GLUL/NOS3/ASS1	4
KEGG	hsa05031	Amphetamine addiction	11/1141	69/8135	0.3731	0.7286	0.656	PPP3R1/SLC18A1/PRKCA/MAOA/CAMK2G/CALM3/CALML5/JUN/GRIN1/CREB3L2/PPP1R1B	11
KEGG	hsa00565	Ether lipid metabolism	8/1141	49/8135	0.3804	0.7327	0.6598	GAL3ST1/PLD1/PLA2G4C/CHPT1/PAFAH2/PLD4/LPCAT2/PLA2G10	8
KEGG	hsa05030	Cocaine addiction	8/1141	49/8135	0.3804	0.7327	0.6598	SLC18A1/MAOA/GNAI3/DLG4/JUN/GRIN1/CREB3L2/PPP1R1B	8
KEGG	hsa05410	Hypertrophic cardiomyopathy	14/1141	90/8135	0.3818	0.7327	0.6598	TPM1/ITGA10/ITGA7/ITGA9/CACNG3/IL6/CACNA2D3/TPM4/EMD/TPM3/RYR2/CACNG2/EDN1/TNNT2	14
KEGG	hsa04660	T cell receptor signaling pathway	16/1141	104/8135	0.3858	0.7361	0.6628	PPP3R1/PIK3R1/PAK1/IL10/IKBKB/PAK2/VAV1/CDC42/RHOA/MAPK13/MAP3K14/SOS1/JUN/MAPK3/NRAS/IL5	16
KEGG	hsa04371	Apelin signaling pathway	21/1141	139/8135	0.392	0.7401	0.6664	ADCY3/RYR1/GNAI3/ITPR2/MEF2A/CALM3/GNG5/NOS3/GNG12/GNB1/CCND1/MTOR/CALML5/RYR2/SMAD3/MAP1LC3A/MAPK3/NRAS/PIK3R4/AGTR1/GNG11	21
KEGG	hsa00512	Mucin type O-glycan biosynthesis	6/1141	36/8135	0.393	0.7401	0.6664	B4GALT5/GALNT2/GALNT6/ST3GAL2/GALNT1/ST6GALNAC4	6
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1141	77/8135	0.3945	0.7401	0.6664	ITGA10/ITGA7/ITGA9/CACNG3/JUP/CACNA2D3/GJA1/EMD/RYR2/CACNG2/CDH2/CTNNA1	12
KEGG	hsa04614	Renin-angiotensin system	4/1141	23/8135	0.4068	0.7529	0.678	CTSA/KLK2/ATP6AP2/AGTR1	4
KEGG	hsa04929	GnRH secretion	10/1141	64/8135	0.4089	0.7529	0.678	PIK3R1/PRKCA/ITPR2/CACNA1I/GNRH1/HCN2/MAPK3/NRAS/HCN1/KCNN1	10
KEGG	hsa04721	Synaptic vesicle cycle	12/1141	78/8135	0.4127	0.7529	0.678	SLC1A3/SLC18A1/ATP6V0D1/SLC6A7/SLC6A5/DNM1/CPLX2/ATP6V1E1/UNC13C/SLC6A11/ATP6V1B1/ATP6V0B	12
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1141	106/8135	0.4169	0.7529	0.678	ADCY3/PRKCA/LRP5/GNAI3/ITPR2/MAFB/MEF2A/PLD1/HBEGF/SLC9A3R1/RHOA/BCL2/SOST/MAPK3/BGLAP/CREB3L2	16
KEGG	hsa04270	Vascular smooth muscle contraction	20/1141	134/8135	0.4188	0.7529	0.678	ADCY3/PRKCA/ROCK1/NPR1/ROCK2/ITPR2/MYL6B/CALM3/NPPB/PLA2G4C/RHOA/MYH11/CALML5/NPPA/MAPK3/EDN3/ADRA1B/AGTR1/EDN1/PLA2G10	20
KEGG	hsa00920	Sulfur metabolism	2/1141	10/8135	0.4195	0.7529	0.678	SELENBP1/IMPAD1	2
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/1141	37/8135	0.4196	0.7529	0.678	GLUL/CAD/PPAT/ASS1/ASNS/NIT2	6
KEGG	hsa01250	Biosynthesis of nucleotide sugars	6/1141	37/8135	0.4196	0.7529	0.678	HK2/CMAS/NAGK/PMM2/PGM3/UAP1L1	6
KEGG	hsa00270	Cysteine and methionine metabolism	8/1141	51/8135	0.4256	0.7539	0.6789	MTR/DNMT3A/MAT2A/DNMT1/MAT1A/BCAT1/MRI1/CTH	8
KEGG	hsa04913	Ovarian steroidogenesis	8/1141	51/8135	0.4256	0.7539	0.6789	ADCY3/AKR1C3/PLA2G4C/BMP6/CYP11A1/PTGS2/IGF1R/CYP1B1	8
KEGG	hsa00480	Glutathione metabolism	9/1141	58/8135	0.4275	0.7539	0.6789	PGD/MGST1/GSTM4/GSTM2/GSR/GSTM1/PRDX6/GGT5/CHAC2	9
KEGG	hsa04137	Mitophagy - animal	11/1141	72/8135	0.43	0.7539	0.6789	MITF/RAB7A/RPS27A/TFE3/SQSTM1/JUN/TBC1D17/MAP1LC3A/NRAS/BCL2L1/ATG9B	11
KEGG	hsa00450	Selenocompound metabolism	3/1141	17/8135	0.4337	0.7539	0.6789	MTR/MARS2/CTH	3
KEGG	hsa00910	Nitrogen metabolism	3/1141	17/8135	0.4337	0.7539	0.6789	GLUL/CA1/CA4	3
KEGG	hsa00052	Galactose metabolism	5/1141	31/8135	0.4438	0.7602	0.6846	HK2/PFKM/AKR1B10/MGAM/B4GALT1	5
KEGG	hsa04210	Apoptosis	20/1141	136/8135	0.4465	0.7602	0.6846	CTSD/PIK3R1/ITPR2/IKBKB/NTRK1/PARP2/MAP3K14/BCL2/HTRA2/JUN/MAPK3/NRAS/NGF/BCL2L1/TNFRSF10A/BCL2A1/BAX/BAK1/APAF1/PARP4	20
KEGG	hsa00600	Sphingolipid metabolism	8/1141	52/8135	0.4481	0.7602	0.6846	GALC/DEGS2/GAL3ST1/NEU3/KDSR/SGMS1/SGPP2/SMPD1	8
KEGG	hsa04330	Notch signaling pathway	9/1141	59/8135	0.4486	0.7602	0.6846	PSEN2/ADAM17/TLE3/TLE6/DLL3/HEYL/ATXN1/ATXN1L/APH1A	9
KEGG	hsa04260	Cardiac muscle contraction	13/1141	87/8135	0.4488	0.7602	0.6846	ASPH/TPM1/COX5A/CACNG3/COX6B2/CACNA2D3/TPM4/TPM3/COX7A1/RYR2/CACNG2/SLC9A7/TNNT2	13
KEGG	hsa04720	Long-term potentiation	10/1141	67/8135	0.4688	0.7809	0.7031	GRM1/PPP3R1/PRKCA/ITPR2/CAMK2G/CALM3/CALML5/MAPK3/GRIN1/NRAS	10
KEGG	hsa04930	Type II diabetes mellitus	7/1141	46/8135	0.4713	0.7809	0.7031	PIK3R1/SOCS3/HK2/IKBKB/IRS4/MTOR/MAPK3	7
KEGG	hsa00061	Fatty acid biosynthesis	3/1141	18/8135	0.4727	0.7809	0.7031	ACACB/ACSL1/OLAH	3
KEGG	hsa00511	Other glycan degradation	3/1141	18/8135	0.4727	0.7809	0.7031	ENGASE/NEU3/MANBA	3
KEGG	hsa00640	Propanoate metabolism	5/1141	32/8135	0.4727	0.7809	0.7031	ACACB/PCCA/EHHADH/DBT/ACSS3	5
KEGG	hsa04022	cGMP-PKG signaling pathway	24/1141	167/8135	0.4827	0.7906	0.7119	ADCY3/EDNRB/PPP3R1/ROCK1/NPR1/GNAI3/ROCK2/ITPR2/MEF2A/CALM3/NPPB/NOS3/KNG1/VASP/IRS4/RHOA/CALML5/NPPA/MAPK3/CREB3L2/ADRA1B/AGTR1/SRF/BDKRB2	24
KEGG	hsa04211	Longevity regulating pathway	13/1141	89/8135	0.4834	0.7906	0.7119	ADCY3/PIK3R1/PPARG/RHEB/IRS4/EHMT1/MTOR/NRAS/CREB3L2/ADIPOR1/BAX/TSC1/IGF1R	13
KEGG	hsa05171	Coronavirus disease - COVID-19	33/1141	232/8135	0.4944	0.8045	0.7245	C1QB/C1QC/C1QA/C3AR1/NRP1/PIK3R1/IFNAR2/PRKCA/TLR2/IKBKB/RPS4Y1/IL6/RPS27A/HBEGF/NLRP3/TLR4/RPS27/RPL23/ADAM17/MAVS/MAPK13/C5/RPL38/RPS15/RPL14/JUN/MAPK3/RPS15A/FCGR2A/AGTR1/C1S/C6/TAB2	33
KEGG	hsa05215	Prostate cancer	14/1141	97/8135	0.4984	0.8072	0.7269	PIK3R1/IKBKB/E2F3/IL1R2/E2F2/CCND1/MTOR/SOS1/BCL2/CCNE2/MAPK3/NRAS/CREB3L2/IGF1R	14
KEGG	hsa00564	Glycerophospholipid metabolism	14/1141	98/8135	0.5148	0.8298	0.7471	AGPAT2/DGKG/PLD1/DGKE/MBOAT2/PLA2G4C/AGPAT5/GPD1/GPAM/CHPT1/DGKI/PLD4/LPCAT2/PLA2G10	14
KEGG	hsa00280	Valine, leucine and isoleucine degradation	7/1141	48/8135	0.5186	0.8317	0.7489	PCCA/EHHADH/MCCC1/DBT/BCAT1/AOX1/HADH	7
KEGG	hsa04340	Hedgehog signaling pathway	8/1141	56/8135	0.5362	0.8479	0.7635	KIF3A/DISP1/CCND1/SPOP/BCL2/GAS1/EVC2/CCND2	8
KEGG	hsa04923	Regulation of lipolysis in adipocytes	8/1141	56/8135	0.5362	0.8479	0.7635	ADCY3/PIK3R1/NPR1/GNAI3/IRS4/NPPA/PNPLA2/PTGS2	8
KEGG	hsa04966	Collecting duct acid secretion	4/1141	27/8135	0.5363	0.8479	0.7635	ATP6V0D1/SLC4A1/ATP6V1E1/ATP6V1B1	4
KEGG	hsa05017	Spinocerebellar ataxia	20/1141	143/8135	0.5427	0.854	0.769	GRM1/PIK3R1/RYR1/PRKCA/ITPR2/MYOD1/ATXN2/PSMC3/MTOR/PSMD9/PSMA6/ATXN1/OMA1/GRIN1/PSMB6/PIK3R4/ATXN1L/ULK2/ATG2B/SPTBN2	20
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1141	20/8135	0.5465	0.8543	0.7692	CSGALNACT2/CSGALNACT1/XYLT2	3
KEGG	hsa00380	Tryptophan metabolism	6/1141	42/8135	0.5481	0.8543	0.7692	MAOA/EHHADH/AOX1/ALDH8A1/HADH/CYP1B1	6
KEGG	hsa05144	Malaria	7/1141	50/8135	0.5641	0.8752	0.7881	HBB/TLR2/SDC2/IL10/IL6/TLR4/THBS4	7
KEGG	hsa01240	Biosynthesis of cofactors	21/1141	153/8135	0.579	0.8913	0.8025	NMNAT2/PANK3/QPRT/ALAS2/AKR1A1/DHFR/MAT2A/AK3/NMNAT1/NMNAT3/MAT1A/PMM2/BCAT1/MTHFD1L/CAD/COQ6/CTPS2/EARS2/MTHFD1/LIPT1/LIAS	21
KEGG	hsa00770	Pantothenate and CoA biosynthesis	3/1141	21/8135	0.5811	0.8913	0.8025	VNN1/PANK3/BCAT1	3
KEGG	hsa00330	Arginine and proline metabolism	7/1141	51/8135	0.5862	0.8913	0.8025	ARG1/SMOX/MAOA/PRODH2/NOS3/ALDH18A1/SAT2	7
KEGG	hsa05014	Amyotrophic lateral sclerosis	50/1141	364/8135	0.5886	0.8913	0.8025	PPP3R1/NDUFA4L2/MAP2K6/KLC4/NUP205/NRG1/NDUFA12/DNAH5/DCTN6/NUP214/COX5A/TUBB6/ATXN2/NUP50/NUP35/PSMC3/SQSTM1/RAB1A/COX6B2/SETX/TPR/DNAH10/MAPK13/DCTN3/DNAH11/COX7A1/MTOR/PSMD9/PSMA6/NUP88/BCL2/DCTN4/NDUFB2/MAP1LC3A/NEFH/GRIN1/NXT2/PSMB6/BCL2L1/PIK3R4/TUBB2A/BAX/ULK2/APAF1/ATG2B/NDUFB6/NDUFB9/ACTR1A/NUP160/UBQLN4	50
KEGG	hsa04728	Dopaminergic synapse	18/1141	132/8135	0.5903	0.8913	0.8025	SLC18A1/PRKCA/MAOA/GNAI3/ITPR2/DRD4/CAMK2G/CALM3/GNG5/PPP2R3A/GNG12/MAPK13/DRD5/GNB1/CALML5/CREB3L2/PPP1R1B/GNG11	18
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	9/1141	66/8135	0.5906	0.8913	0.8025	NARS2/FARS2/LARS2/VARS2/MARS2/EARS2/SARS2/HARS2/AARS2	9
KEGG	hsa04744	Phototransduction	4/1141	29/8135	0.5955	0.8947	0.8056	GRK1/CALM3/GNB1/CALML5	4
KEGG	hsa05414	Dilated cardiomyopathy	13/1141	96/8135	0.5997	0.8968	0.8075	ADCY3/TPM1/ITGA10/ITGA7/ITGA9/CACNG3/CACNA2D3/TPM4/EMD/TPM3/RYR2/CACNG2/TNNT2	13
KEGG	hsa04723	Retrograde endocannabinoid signaling	20/1141	148/8135	0.6083	0.9034	0.8134	ADCY3/GRM1/NDUFA4L2/PRKCA/NDUFA12/GNAI3/ITPR2/NAPEPLD/GNG5/GNG12/MAPK13/GNB1/GABRB1/NDUFB2/MAPK3/GNG11/NDUFB6/NDUFB9/PTGS2/FAAH	20
KEGG	hsa04620	Toll-like receptor signaling pathway	14/1141	104/8135	0.6095	0.9034	0.8134	PIK3R1/MAP2K6/IFNAR2/TLR2/TOLLIP/IKBKB/IL6/IRF5/TLR4/MAPK13/JUN/MAPK3/CD14/TAB2	14
KEGG	hsa00030	Pentose phosphate pathway	4/1141	30/8135	0.6234	0.9198	0.8283	PGD/PFKM/FBP1/ALDOA	4
KEGG	hsa04725	Cholinergic synapse	15/1141	113/8135	0.633	0.9284	0.8359	ADCY3/PIK3R1/PRKCA/GNAI3/ITPR2/CAMK2G/GNG5/GNG12/GNB1/CHRNA4/BCL2/MAPK3/NRAS/CREB3L2/GNG11	15
KEGG	hsa00140	Steroid hormone biosynthesis	8/1141	61/8135	0.6376	0.9284	0.8359	AKR1C3/SRD5A1/AKR1C2/STS/HSD11B1L/CYP11A1/SRD5A3/CYP1B1	8
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1141	15/8135	0.643	0.9284	0.8359	ST3GAL2/ST6GALNAC4	2
KEGG	hsa03430	Mismatch repair	3/1141	23/8135	0.645	0.9284	0.8359	MSH2/MSH6/PCNA	3
KEGG	hsa04920	Adipocytokine signaling pathway	9/1141	69/8135	0.6459	0.9284	0.8359	ACACB/CPT1C/SOCS3/ACSL1/IKBKB/AGRP/IRS4/MTOR/ADIPOR1	9
KEGG	hsa05211	Renal cell carcinoma	9/1141	69/8135	0.6459	0.9284	0.8359	PIK3R1/PAK1/PAK2/TFE3/CDC42/SOS1/JUN/MAPK3/NRAS	9
KEGG	hsa04922	Glucagon signaling pathway	14/1141	107/8135	0.6535	0.9352	0.8421	ACACB/PPP3R1/CPT1C/ITPR2/PFKM/CAMK2G/CALM3/FBP1/GYS2/PYGB/CALML5/SIK2/CREB3L2/SIK1	14
KEGG	hsa05230	Central carbon metabolism in cancer	9/1141	70/8135	0.6634	0.9453	0.8512	PIK3R1/HK2/FGFR3/PFKM/NTRK1/MTOR/MAPK3/NRAS/SIRT6	9
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	17/1141	131/8135	0.6743	0.9488	0.8543	PPP3R1/IFNGR1/PIK3R1/IFNAR2/HLA-G/PRKCA/IFNGR2/HLA-B/NCR1/PAK1/VAV1/SHC3/HLA-C/SOS1/MAPK3/NRAS/TNFRSF10A	17
KEGG	hsa03250	Viral life cycle - HIV-1	8/1141	63/8135	0.6744	0.9488	0.8543	APOBEC3B/TNPO3/PDCD6IP/TSG101/CHMP4B/APOBEC3A/PSIP1/CCNT1	8
KEGG	hsa05217	Basal cell carcinoma	8/1141	63/8135	0.6744	0.9488	0.8543	FZD5/APC2/APC/WNT1/FZD2/BAX/BAK1/FZD4	8
KEGG	hsa05012	Parkinson disease	35/1141	266/8135	0.6876	0.9613	0.8656	SLC18A1/UBE2J1/NDUFA4L2/KLC4/MAOA/NDUFA12/GNAI3/ITPR2/COX5A/TUBB6/RPS27A/CAMK2G/CALM3/PSMC3/SLC39A5/COX6B2/SLC39A8/TXN/MAPT/TRAP1/COX7A1/PSMD9/CALML5/PSMA6/HTRA2/NDUFB2/PSMB6/BCL2L1/TUBB2A/BAX/SLC11A2/APAF1/NDUFB6/NDUFB9/DUSP1	35
KEGG	hsa05010	Alzheimer disease	51/1141	384/8135	0.6891	0.9613	0.8656	PPP3R1/NDUFA4L2/FZD5/PIK3R1/KLC4/GAPDH/LRP5/NDUFA12/ITPR2/ADAM10/COX5A/IKBKB/TUBB6/IL6/PSEN2/CALM3/PSMC3/SLC39A5/COX6B2/SLC39A8/APC2/IRS4/APC/ADAM17/MAPT/COX7A1/MTOR/PSMD9/CALML5/PSMA6/NDUFB2/MAPK3/GRIN1/NRAS/WNT1/PSMB6/FZD2/PIK3R4/DKK2/TUBB2A/DKK4/ULK2/SLC11A2/APH1A/APAF1/ATG2B/NDUFB6/CSF1/NDUFB9/PTGS2/FZD4	51
KEGG	hsa04130	SNARE interactions in vesicular transport	4/1141	33/8135	0.6993	0.9707	0.8741	STX8/YKT6/VAMP3/SNAP29	4
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1141	25/8135	0.7017	0.9707	0.8741	PLA2G4C/FADS2/PLA2G10	3
KEGG	hsa04927	Cortisol synthesis and secretion	8/1141	65/8135	0.7089	0.9725	0.8757	ADCY3/ITPR2/CACNA1I/KCNK3/CREB3L2/AGTR1/MC2R/CYP11A1	8
KEGG	hsa00562	Inositol phosphate metabolism	9/1141	73/8135	0.7127	0.9725	0.8757	INPP5D/SACM1L/INPP4A/INPP5F/PIK3C2B/OCRL/IMPA1/MTMR2/PIP5K1A	9
KEGG	hsa05160	Hepatitis C	20/1141	157/8135	0.7146	0.9725	0.8757	PIK3R1/IFNAR2/SOCS3/CLDN14/CLDN5/IKBKB/E2F3/E2F2/CDK6/MAVS/OCLN/CCND1/SOS1/MAPK3/NRAS/CLDN8/CLDN3/BAX/BAK1/APAF1	20
KEGG	hsa04714	Thermogenesis	30/1141	232/8135	0.7152	0.9725	0.8757	ADCY3/CPT1C/NDUFA4L2/PPARG/NDUFA12/NPR1/ACSL1/COX5A/NPPB/COX6B2/KDM1A/RHEB/MAPK13/COX7A1/MTOR/SMARCD2/SOS1/NPPA/NDUFB2/NRAS/CREB3L2/SIRT6/COX11/PNPLA2/SMARCC2/NDUFAF4/TSC1/COX18/NDUFB6/NDUFB9	30
KEGG	hsa04979	Cholesterol metabolism	6/1141	50/8135	0.7211	0.9725	0.8757	SORT1/CYP27A1/APOC1/LPA/ANGPTL3/ABCG5	6
KEGG	hsa03020	RNA polymerase	4/1141	34/8135	0.722	0.9725	0.8757	CD3EAP/POLR3A/POLR1B/POLR1E	4
KEGG	hsa05415	Diabetic cardiomyopathy	26/1141	203/8135	0.7235	0.9725	0.8757	CTSD/NDUFA4L2/PIK3R1/GAPDH/PRKCA/NDUFA12/COX5A/CAMK2G/COX6B2/GYS2/NOS3/MAPK13/COX7A1/MTOR/GSR/RYR2/SMAD3/NDUFB2/COL1A1/AGTR1/TGFBR2/COL3A1/COL1A2/NDUFB6/NDUFB9/TBC1D4	26
KEGG	hsa04146	Peroxisome	10/1141	82/8135	0.7312	0.9789	0.8814	EHHADH/ACSL1/PECR/PEX12/SLC25A17/PEX19/ABCD4/XDH/ACOX2/ACOT8	10
KEGG	hsa00071	Fatty acid degradation	5/1141	43/8135	0.7401	0.9868	0.8885	CYP2U1/CPT1C/EHHADH/ACSL1/HADH	5
KEGG	hsa05020	Prion disease	35/1141	273/8135	0.7457	0.9903	0.8917	C1QB/C1QC/C1QA/PPP3R1/NDUFA4L2/PIK3R1/KLC4/LAMC1/RYR1/NDUFA12/ITPR2/COX5A/CAV1/TUBB6/IL6/PSMC3/COX6B2/MAPK13/C5/COX7A1/PSMD9/RYR2/PSMA6/NDUFB2/HSPA1A/MAPK3/GRIN1/CREB3L2/PSMB6/TUBB2A/BAX/APAF1/NDUFB6/NDUFB9/C6	35
KEGG	hsa04971	Gastric acid secretion	9/1141	76/8135	0.7571	0.9925	0.8937	ADCY3/PRKCA/GNAI3/ITPR2/CAMK2G/CALM3/HRH2/CALML5/KCNJ15	9
KEGG	hsa04114	Oocyte meiosis	16/1141	131/8135	0.7627	0.9925	0.8937	ADCY3/PPP3R1/SPDYE1/ITPR2/ANAPC1/CAMK2G/CALM3/ANAPC7/MAPK13/CALML5/MAD2L1/CCNE2/MAPK3/CCNB1/FBXO5/IGF1R	16
KEGG	hsa00350	Tyrosine metabolism	4/1141	36/8135	0.7636	0.9925	0.8937	MAOA/TYR/GSTZ1/AOX1	4
KEGG	hsa04931	Insulin resistance	13/1141	108/8135	0.7653	0.9925	0.8937	ACACB/PIK3R1/SOCS3/PTPN1/IKBKB/IL6/GYS2/NOS3/PYGB/MLX/MTOR/CREB3L2/TBC1D4	13
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/1141	223/8135	0.7668	0.9925	0.8937	AKR1C3/NDUFA4L2/PIK3R1/AKR1C2/MGST1/NDUFA12/AKR1A1/PTPN1/COX5A/IKBKB/PTK2/PLD1/GSTM4/COX6B2/MAPK13/GSTM2/COX7A1/MAP3K14/EPHX3/SOS1/JUN/NDUFB2/GSTM1/MAPK3/NRAS/NDUFB6/NDUFB9/CYP1B1	28
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	8/1141	69/8135	0.7704	0.9925	0.8937	AKR1C2/MGST1/GSTM4/GSTM2/GSTM1/HSD11B1L/PTGS2/CYP1B1	8
KEGG	hsa04932	Non-alcoholic fatty liver disease	19/1141	155/8135	0.7719	0.9925	0.8937	NDUFA4L2/PIK3R1/PPARG/SOCS3/NDUFA12/COX5A/IKBKB/IL6/CDC42/COX6B2/MLX/MAPK13/COX7A1/JUN/NDUFB2/ADIPOR1/BAX/NDUFB6/NDUFB9	19
KEGG	hsa00650	Butanoate metabolism	3/1141	28/8135	0.7734	0.9925	0.8937	EHHADH/ACSM3/HADH	3
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	4/1141	37/8135	0.7825	0.9925	0.8937	PIK3R1/PRKCA/SCNN1B/MAPK3	4
KEGG	hsa04612	Antigen processing and presentation	9/1141	78/8135	0.7839	0.9925	0.8937	HLA-DPB1/HLA-G/HLA-DMB/HLA-DPA1/HLA-B/HLA-DMA/HLA-C/HSPA1A/RFX5	9
KEGG	hsa04213	Longevity regulating pathway - multiple species	7/1141	62/8135	0.7855	0.9925	0.8937	ADCY3/PIK3R1/IRS4/MTOR/HSPA1A/NRAS/IGF1R	7
KEGG	hsa04914	Progesterone-mediated oocyte maturation	12/1141	102/8135	0.7862	0.9925	0.8937	ADCY3/PIK3R1/SPDYE1/GNAI3/ANAPC1/ANAPC7/MAPK13/CCNA1/MAD2L1/MAPK3/CCNB1/IGF1R	12
KEGG	hsa04972	Pancreatic secretion	12/1141	102/8135	0.7862	0.9925	0.8937	ADCY3/PRKCA/ITPR2/RHOA/PRSS2/CELA2B/BST1/SLC12A2/RYR2/SCT/CPA2/PLA2G10	12
KEGG	hsa03050	Proteasome	5/1141	46/8135	0.7926	0.9958	0.8967	PSMC3/PSMD9/PSMA6/PSMB6/POMP	5
KEGG	hsa00310	Lysine degradation	7/1141	63/8135	0.7994	0.9958	0.8967	EHHADH/PLOD2/EHMT1/SETD2/PRDM6/SMYD2/HADH	7
KEGG	hsa04217	Necroptosis	19/1141	159/8135	0.8081	0.9958	0.8967	IFNGR1/IFNAR2/IFNGR2/STAT5A/CAMK2G/GLUL/SQSTM1/CHMP4B/NLRP3/PYGB/TLR4/PLA2G4C/CHMP1A/JAK3/BCL2/TRAF5/TNFRSF10A/BAX/SMPD1	19
KEGG	hsa00514	Other types of O-glycan biosynthesis	5/1141	47/8135	0.8081	0.9958	0.8967	GALNT2/GALNT6/GXYLT2/B4GALT1/GALNT1	5
KEGG	hsa03420	Nucleotide excision repair	5/1141	47/8135	0.8081	0.9958	0.8967	ERCC6/XPC/PCNA/ERCC4/RAD23B	5
KEGG	hsa04973	Carbohydrate digestion and absorption	5/1141	47/8135	0.8081	0.9958	0.8967	PIK3R1/HK2/SLC5A1/MGAM/SLC2A5	5
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1141	11/8135	0.8105	0.9958	0.8967	COQ6	1
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1141	30/8135	0.8129	0.9958	0.8967	PCCA/HYI/GLUL	3
KEGG	hsa04727	GABAergic synapse	10/1141	89/8135	0.8188	0.9994	0.8999	ADCY3/PRKCA/GNAI3/GLUL/GNG5/GNG12/GNB1/GABRB1/SLC6A11/GNG11	10
KEGG	hsa01212	Fatty acid metabolism	6/1141	57/8135	0.8297	0.9999	0.9003	CPT1C/EHHADH/ACSL1/FADS2/ELOVL2/HADH	6
KEGG	hsa00240	Pyrimidine metabolism	6/1141	58/8135	0.842	0.9999	0.9003	CDA/ENTPD5/CAD/DTYMK/CTPS2/UPP1	6
KEGG	hsa00010	Glycolysis / Gluconeogenesis	7/1141	67/8135	0.8481	0.9999	0.9003	GAPDH/PGK1/HK2/AKR1A1/PFKM/FBP1/ALDOA	7
KEGG	hsa00515	Mannose type O-glycan biosynthesis	2/1141	23/8135	0.8534	0.9999	0.9003	FKTN/B4GALT1	2
KEGG	hsa03060	Protein export	2/1141	23/8135	0.8534	0.9999	0.9003	SPCS3/SEC61B	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/1141	23/8135	0.8534	0.9999	0.9003	SLC9A3/CA4	2
KEGG	hsa04970	Salivary secretion	10/1141	93/8135	0.8581	0.9999	0.9003	ADCY3/CAMP/PRKCA/ITPR2/AQP5/CALM3/BST1/SLC12A2/CALML5/ADRA1B	10
KEGG	hsa04120	Ubiquitin mediated proteolysis	16/1141	142/8135	0.8606	0.9999	0.9003	UBE2J1/HUWE1/SOCS3/BIRC6/UBE2E3/RPS27A/ANAPC1/UBE2H/UBE2QL1/UBE4A/ANAPC7/UBE2N/UBA2/FANCL/UBE2A/SKP2	16
KEGG	hsa00190	Oxidative phosphorylation	15/1141	134/8135	0.8608	0.9999	0.9003	PPA2/NDUFA4L2/ATP6V0D1/NDUFA12/COX5A/COX6B2/COX7A1/NDUFB2/ATP6AP1/ATP6V1E1/COX11/NDUFB6/NDUFB9/ATP6V1B1/ATP6V0B	15
KEGG	hsa04975	Fat digestion and absorption	4/1141	43/8135	0.8717	0.9999	0.9003	AGPAT2/FABP1/ABCG5/PLA2G10	4
KEGG	hsa04622	RIG-I-like receptor signaling pathway	7/1141	70/8135	0.878	0.9999	0.9003	ATG12/IKBKB/MAVS/MAPK13/DDX3X/RNF125/TRIM25	7
KEGG	hsa04919	Thyroid hormone signaling pathway	13/1141	121/8135	0.8839	0.9999	0.9003	PIK3R1/PRKCA/NCOA2/PFKM/RHEB/MED30/MED17/CCND1/MED12L/MTOR/MAPK3/NRAS/TBC1D4	13
KEGG	hsa05034	Alcoholism	21/1141	187/8135	0.8915	0.9999	0.9003	SLC18A1/MAOA/HDAC8/GNAI3/CRH/CALM3/GNG5/SHC3/GNG12/SLC29A2/GNB1/CALML5/SOS1/HDAC9/HAT1/MAPK3/GRIN1/NRAS/CREB3L2/PPP1R1B/GNG11	21
KEGG	hsa02010	ABC transporters	4/1141	45/8135	0.8935	0.9999	0.9003	ABCD4/ABCC5/DEFB1/ABCG5	4
KEGG	hsa03022	Basal transcription factors	4/1141	45/8135	0.8935	0.9999	0.9003	TAF5L/TAF15/TAF3/TAF8	4
KEGG	hsa05032	Morphine addiction	9/1141	91/8135	0.9075	0.9999	0.9003	ADCY3/PRKCA/GNAI3/PDE1A/GNG5/GNG12/GNB1/GABRB1/GNG11	9
KEGG	hsa00062	Fatty acid elongation	2/1141	27/8135	0.909	0.9999	0.9003	ELOVL2/HADH	2
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	2/1141	27/8135	0.909	0.9999	0.9003	FADS2/ELOVL2	2
KEGG	hsa05206	MicroRNAs in cancer	36/1141	310/8135	0.911	0.9999	0.9003	SPRY2/DNMT3A/PIK3R1/PRKCA/ROCK1/PIM1/RPS6KA5/TPM1/FGFR3/IKBKB/RASSF1/E2F3/DNMT1/KIF23/BCL2L2/APC2/E2F2/APC/FSCN1/CDK6/RHOA/TIMP3/CCND1/MTOR/SOS1/BCL2/CCNE2/TNC/MAPK3/NRAS/RECK/TNN/CCND2/BAK1/PTGS2/CYP1B1	36
KEGG	hsa00360	Phenylalanine metabolism	1/1141	16/8135	0.9111	0.9999	0.9003	MAOA	1
KEGG	hsa00430	Taurine and hypotaurine metabolism	1/1141	16/8135	0.9111	0.9999	0.9003	GGT5	1
KEGG	hsa00620	Pyruvate metabolism	4/1141	47/8135	0.9119	0.9999	0.9003	ACACB/ME1/AKR1A1/PC	4
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	11/1141	109/8135	0.9132	0.9999	0.9003	NOP10/SPATA5/RPP25/GAR1/FBLL1/RCL1/BMS1/GTPBP4/WDR43/NXT2/NAT10	11
KEGG	hsa05322	Systemic lupus erythematosus	14/1141	136/8135	0.9224	0.9999	0.9003	C1QB/C1QC/HLA-DPB1/C1QA/HLA-DMB/FCGR1A/HLA-DPA1/IL10/HLA-DMA/C5/FCGR2A/ELANE/C1S/C6	14
KEGG	hsa01232	Nucleotide metabolism	8/1141	85/8135	0.9241	0.9999	0.9003	CDA/AK3/ENTPD5/XDH/DTYMK/CTPS2/UPP1/GDA	8
KEGG	hsa00591	Linoleic acid metabolism	2/1141	29/8135	0.9287	0.9999	0.9003	PLA2G4C/PLA2G10	2
KEGG	hsa05033	Nicotine addiction	3/1141	40/8135	0.9334	0.9999	0.9003	GABRB1/CHRNA4/GRIN1	3
KEGG	hsa03040	Spliceosome	15/1141	147/8135	0.9339	0.9999	0.9003	THOC1/DDX5/ISY1/MAGOH/PRPF8/BUD31/U2AF2/RP9/PLRG1/SF3B2/HSPA1A/AQR/PCBP1/HNRNPC/SNRNP200	15
KEGG	hsa04613	Neutrophil extracellular trap formation	20/1141	190/8135	0.9392	0.9999	0.9003	FPR2/FPR1/CAMP/PIK3R1/ITGAM/FCGR1A/PRKCA/TLR2/HDAC8/AQP9/TLR4/MAPK13/C5/MTOR/HDAC9/HAT1/MAPK3/FCGR2A/CLEC7A/ELANE	20
KEGG	hsa03018	RNA degradation	7/1141	79/8135	0.9398	0.9999	0.9003	PABPC1L/PFKM/CNOT1/PAN2/EXOSC5/EXOSC8/CNOT10	7
KEGG	hsa03015	mRNA surveillance pathway	9/1141	97/8135	0.9403	0.9999	0.9003	UPF3B/SYMPK/PABPC1L/MAGOH/PPP2R3A/GSPT1/NXT2/SSU72/PELO	9
KEGG	hsa01200	Carbon metabolism	11/1141	115/8135	0.9423	0.9999	0.9003	ME1/GAPDH/PGD/PGK1/HK2/PCCA/PSPH/PFKM/FBP1/PC/ALDOA	11
KEGG	hsa00531	Glycosaminoglycan degradation	1/1141	19/8135	0.9436	0.9999	0.9003	HYAL4	1
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/1141	19/8135	0.9436	0.9999	0.9003	BCAT1	1
KEGG	hsa00410	beta-Alanine metabolism	2/1141	31/8135	0.9444	0.9999	0.9003	SMOX/EHHADH	2
KEGG	hsa00983	Drug metabolism - other enzymes	7/1141	80/8135	0.9446	0.9999	0.9003	CDA/MGST1/GSTM4/XDH/GSTM2/GSTM1/UPP1	7
KEGG	hsa00982	Drug metabolism - cytochrome P450	6/1141	72/8135	0.9502	0.9999	0.9003	MAOA/MGST1/GSTM4/GSTM2/AOX1/GSTM1	6
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/1141	53/8135	0.9513	0.9999	0.9003	PRKCA/KLK2/DNM1/BDKRB2	4
KEGG	hsa00100	Steroid biosynthesis	1/1141	20/8135	0.9515	0.9999	0.9003	SQLE	1
KEGG	hsa00040	Pentose and glucuronate interconversions	2/1141	34/8135	0.9619	0.9999	0.9003	AKR1A1/AKR1B10	2
KEGG	hsa04918	Thyroid hormone synthesis	6/1141	75/8135	0.962	0.9999	0.9003	ADCY3/PRKCA/ITPR2/SLC5A5/GSR/CREB3L2	6
KEGG	hsa05016	Huntington disease	33/1141	306/8135	0.9635	0.9999	0.9003	SLC1A3/NDUFA4L2/KLC4/PPARG/NDUFA12/DNAH5/DCTN6/COX5A/TUBB6/PSMC3/COX6B2/DNAH10/DCTN3/DNAH11/COX7A1/MTOR/PSMD9/DLG4/PSMA6/DCTN4/NDUFB2/GRIN1/CREB3L2/PSMB6/PIK3R4/TUBB2A/BAX/ULK2/APAF1/ATG2B/NDUFB6/NDUFB9/ACTR1A	33
KEGG	hsa00340	Histidine metabolism	1/1141	22/8135	0.9642	0.9999	0.9003	MAOA	1
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1141	78/8135	0.9711	0.9999	0.9003	MGST1/GSTM4/GSTM2/GSTM1/HSD11B1L/CYP1B1	6
KEGG	hsa04977	Vitamin digestion and absorption	1/1141	24/8135	0.9736	0.9999	0.9003	SLC5A6	1
KEGG	hsa04976	Bile secretion	7/1141	89/8135	0.9745	0.9999	0.9003	ADCY3/SLC5A1/AQP9/SLC9A3/SCT/HMGCR/ABCG5	7
KEGG	hsa04978	Mineral absorption	4/1141	60/8135	0.9765	0.9999	0.9003	STEAP1/SLC5A1/SLC9A3/SLC11A2	4
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1141	26/8135	0.9805	0.9999	0.9003	PIGL	1
KEGG	hsa04623	Cytosolic DNA-sensing pathway	4/1141	63/8135	0.983	0.9999	0.9003	IKBKB/IL6/MAVS/POLR3A	4
KEGG	hsa03440	Homologous recombination	2/1141	41/8135	0.9845	0.9999	0.9003	TOP3A/RAD50	2
KEGG	hsa04742	Taste transduction	6/1141	86/8135	0.9866	0.9999	0.9003	GRM1/HTR3C/PDE1A/SCNN1B/HCN4/TAS2R3	6
KEGG	hsa04911	Insulin secretion	6/1141	86/8135	0.9866	0.9999	0.9003	ADCY3/PRKCA/CAMK2G/RYR2/CREB3L2/KCNN1	6
KEGG	hsa00860	Porphyrin metabolism	2/1141	43/8135	0.9881	0.9999	0.9003	ALAS2/EARS2	2
KEGG	hsa00020	Citrate cycle (TCA cycle)	1/1141	30/8135	0.9894	0.9999	0.9003	PC	1
KEGG	hsa00053	Ascorbate and aldarate metabolism	1/1141	30/8135	0.9894	0.9999	0.9003	AKR1A1	1
KEGG	hsa00230	Purine metabolism	10/1141	128/8135	0.9897	0.9999	0.9003	ADCY3/PFAS/NPR1/PDE1A/AK3/ENTPD5/XDH/PPAT/ATIC/GDA	10
KEGG	hsa04710	Circadian rhythm	1/1141	31/8135	0.9909	0.9999	0.9003	CRY2	1
KEGG	hsa03010	Ribosome	11/1141	158/8135	0.9983	1	0.9004	MRPL23/MRPL28/RPS4Y1/RPS27A/RPS27/RPL23/RPL38/RPS15/RPL14/RPS15A/MRPL14	11
KEGG	hsa00830	Retinol metabolism	2/1141	68/8135	0.9996	1	0.9004	AOX1/ALDH1A3	2
KEGG	hsa04740	Olfactory transduction	10/1141	440/8135	1	1	0.9004	ADCY3/CAMK2G/CALM3/PDE1A/GNB1/CALML5/OR7C2/OR5H1/OR7D2/OR1D2	10