ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04510	Focal adhesion	54/1160	201/8135	1.602e-06	0.0005125	0.000452	ITGB3/COL9A2/MYL9/ITGB5/PDPK1/ITGA4/COL6A1/PRKCB/CAV2/FLT1/JUN/CRKL/VEGFC/LAMC1/TNXB/VWF/CCND1/ITGA7/DIAPH1/RAF1/IGF1R/FN1/LAMC2/SPP1/THBS4/EGFR/VAV1/ITGA9/IGF1/ITGA3/EGF/COL4A1/COL4A2/PAK4/PDGFRA/PIK3CD/THBS3/ACTN1/BCAR1/PDGFRB/FLNC/LAMB1/ITGB8/VAV3/PAK3/FLNA/SOS2/CAV1/COL6A2/KDR/ITGA2/TNC/PARVA/COL1A2	54
KEGG	hsa05205	Proteoglycans in cancer	54/1160	205/8135	3.078e-06	0.0005125	0.000452	ITGB3/CTTN/ARAF/ITGB5/PDPK1/CAMK2G/ITPR1/MAPK11/PRKCB/EIF4B/CAV2/TNF/TWIST1/TGFB2/WNT5B/TGFB1/CCND1/MIR21/NANOG/RAF1/IGF1R/FN1/SDC2/TWIST2/EGFR/VAV1/IGF1/MSN/CBL/MMP9/WNT9A/FZD10/TIMP3/PIK3CD/ANK1/SMO/FRS2/FLNC/GPC1/FZD5/ANK2/VAV3/WNT5A/DCN/FLNA/SOS2/CAV1/HCLS1/MTOR/KDR/ITGA2/FZD4/ARHGEF12/COL1A2	54
KEGG	hsa05165	Human papillomavirus infection	76/1160	331/8135	9.787e-06	0.001086	0.0009581	ITGB3/COL9A2/SLC9A3R1/ITGB5/FADD/MPP5/ITGA4/EP300/PPP2R3C/HEYL/ATP6V1E1/COL6A1/APC/PARD3/IRF1/TNF/PARD6G/DLG1/PPP2CA/LAMC1/WNT5B/TNXB/TCF7L1/CREB1/HES6/VWF/HES1/CCND1/ITGA7/ATP6V0A2/DLG2/CREBBP/RAF1/ATP6V1G3/FN1/LAMC2/PTGER4/SPP1/THBS4/PPP2R5E/EGFR/JAK1/ITGA9/UBR4/RELA/ITGA3/EGF/COL4A1/CSNK1A1/MFNG/COL4A2/HLA-B/WNT9A/FZD10/PIK3CD/THBS3/PDGFRB/CREB3L1/NOTCH1/NOTCH2/LAMB1/FZD5/ITGB8/WNT5A/PARD6A/SOS2/COL6A2/MTOR/BAK1/ITGA2/FZD4/TNC/NOTCH3/HLA-A/PARD6B/COL1A2	76
KEGG	hsa05146	Amoebiasis	30/1160	102/8135	5.47e-05	0.003705	0.003267	CD1C/ARG2/CTSG/ARG1/PRKCB/TNF/TGFB2/LAMC1/IL1R1/TGFB1/FN1/CD1B/LAMC2/HSPB1/RELA/PLCB2/COL4A1/PLCB1/COL4A2/PIK3CD/IL12A/ACTN1/SERPINB9/RAB7B/IL1B/MUC2/LAMB1/CXCL1/GNA14/COL1A2	30
KEGG	hsa04512	ECM-receptor interaction	27/1160	88/8135	5.688e-05	0.003705	0.003267	ITGB3/COL9A2/ITGB5/ITGA4/COL6A1/LAMC1/TNXB/AGRN/VWF/ITGA7/FN1/LAMC2/SPP1/THBS4/NPNT/ITGA9/ITGA3/COL4A1/COL4A2/THBS3/LAMB1/ITGB8/COL6A2/ITGA2/GP1BA/TNC/COL1A2	27
KEGG	hsa05171	Coronavirus disease - COVID-19	55/1160	232/8135	6.675e-05	0.003705	0.003267	C1QB/C1QA/RPS27/C1QC/RPS28/NFKBIB/RPS27L/NFKBIA/MAPK11/PRKCB/TNF/JUN/MMP1/RPS15/C2/SELP/CFB/VWF/UBA52/NRP1/ACE/RPS26/RPLP1/RPL28/RPS3A/FAU/FOS/RPL10/TRAF6/EGFR/IFIH1/JAK1/RELA/RPL29/RSL24D1/F13A1/MMP3/RPS8/RPS4Y1/RPS2/PIK3CD/AGTR1/IL12A/RPL39/RPS10/IL2/C1R/RPL6/IL1B/RPL14/RPS7/C1S/RPL22L1/RPL9/RPL15	55
KEGG	hsa04380	Osteoclast differentiation	34/1160	128/8135	0.0001704	0.007216	0.006364	ITGB3/JUND/FHL2/FOSB/PPARG/NFKB2/NFKBIA/MAPK11/CSF1/SQSTM1/TNF/JUN/TGFB2/LILRA4/IL1R1/TGFB1/CREB1/FCGR2B/MAP3K14/FCGR3B/FOS/BTK/TRAF6/CYLD/LILRB5/JAK1/RELA/TNFRSF11A/PIK3CD/ACP5/IL1B/TREM2/PPP3CB/JUNB	34
KEGG	hsa04810	Regulation of actin cytoskeleton	51/1160	218/8135	0.0001734	0.007216	0.006364	ITGB3/MYL9/IQGAP3/ARAF/ITGB5/ITGA4/APC/WASF2/CRKL/SSH1/ITGA7/DIAPH1/RAF1/FN1/FGF18/BDKRB2/ARHGEF7/EGFR/VAV1/LPAR4/ITGA9/CXCL12/ITGA3/MSN/EGF/PAK4/PDGFRA/PIK3CD/ITGAL/PFN4/ACTN1/WASF1/BCAR1/ENAH/PDGFRB/TMSB4Y/MYH9/DIAPH3/NCKAP1/ITGB8/VAV3/FGD3/PAK3/GNG12/SOS2/ARPC2/ITGA2/MYH10/PFN1/ARHGEF12/SSH3	51
KEGG	hsa04360	Axon guidance	44/1160	182/8135	0.0002194	0.008119	0.007161	ABLIM3/MYL9/PDPK1/CAMK2G/SEMA3B/RGMA/PLXNA3/PARD3/PARD6G/WNT5B/SSH1/SRGAP1/SEMA3G/NRP1/L1CAM/BOC/RAF1/NFATC4/SEMA4D/CXCL12/SEMA6D/SEMA5B/EPHB4/PAK4/PIK3CD/RND1/LRIG2/EFNB2/SMO/ENAH/PLXNA1/PPP3CB/WNT5A/PAK3/PARD6A/SLIT2/NTN4/SEMA3E/SLIT1/ARHGEF12/EPHB2/SSH3/PARD6B/NFATC3	44
KEGG	hsa04151	PI3K-Akt signaling pathway	74/1160	354/8135	0.0003215	0.01045	0.009217	ITGB3/COL9A2/NTF3/ITGB5/PDPK1/ITGA4/PPP2R3C/BDNF/COL6A1/CSF1/EIF4B/HSP90B1/FLT1/PPP2CA/VEGFC/LAMC1/TNXB/LPAR6/CREB1/VWF/CCND1/ITGA7/HSP90AA1/RAF1/IGF1R/FN1/FGF18/GNG11/LAMC2/SPP1/THBS4/PPP2R5E/EGFR/BCL2L1/NTRK2/NOS3/JAK1/LPAR4/ITGA9/IGF1/RELA/ITGA3/GNB3/YWHAZ/EGF/COL4A1/COL4A2/PDGFRA/PIK3CD/OSMR/IL2/THBS3/MCL1/PDGFRB/CREB3L1/TEK/LAMB1/ANGPT2/PKN3/PKN2/ITGB8/MAGI2/GNG12/SOS2/HSP90AB1/COL6A2/MTOR/GHR/KDR/ITGA2/GNGT2/TNC/GNG10/COL1A2	74
KEGG	hsa05215	Prostate cancer	27/1160	97/8135	0.0003452	0.01045	0.009217	ARAF/PDPK1/ERG/EP300/NFKBIA/HSP90B1/TCF7L1/CREB1/CCND1/HSP90AA1/CREBBP/RAF1/IGF1R/EGFR/IGF1/RELA/EGF/MMP3/PDGFRA/MMP9/PIK3CD/PLAT/PDGFRB/CREB3L1/SOS2/HSP90AB1/MTOR	27
KEGG	hsa05202	Transcriptional misregulation in cancer	45/1160	193/8135	0.0004431	0.01144	0.01009	ETV7/MAF/ERG/PPARG/PBX1/HPGD/FLT1/CDK9/LDB1/ELANE/RXRB/FUS/KLF3/CDKN2C/SMAD1/IGF1R/NFKBIZ/TSPAN7/REL/CEBPE/MAX/DDIT3/JUP/GRIA3/BCL2L1/PML/CCNT2/IGF1/RELA/SIX1/MMP3/MMP9/HOXA10/FLI1/PLAT/NUPR1/JMJD1C/HOXA11/RUNX1T1/EWSR1/HOXA9/BAK1/ETV1/SIN3A/IGFBP3	45
KEGG	hsa04926	Relaxin signaling pathway	33/1160	129/8135	0.0004466	0.01144	0.01009	ADCY3/EDNRB/NFKBIA/MAPK11/ADCY7/JUN/VEGFC/MMP1/TGFB1/ADCY4/CREB1/RAF1/GNG11/FOS/EGFR/NOS3/ADCY6/RELA/PLCB2/GNB3/COL4A1/PLCB1/COL4A2/MMP9/PIK3CD/CREB3L1/RXFP2/GNG12/SOS2/GNGT2/ACTA2/GNG10/COL1A2	33
KEGG	hsa04610	Complement and coagulation cascades	23/1160	85/8135	0.001406	0.03345	0.0295	CLU/PROS1/C1QB/C1QA/C1QC/CR1L/CFH/PROC/CD59/C2/CFB/VWF/BDKRB2/SERPING1/F8/CFHR2/F13A1/TFPI/PLAT/C1R/C1S/CFI/A2M	23
KEGG	hsa04141	Protein processing in endoplasmic reticulum	39/1160	171/8135	0.00161	0.03574	0.03152	SEC62/SEC61B/PPP1R15A/MBTPS1/EDEM1/HSP90B1/EIF2AK4/DNAJA1/PDIA3/HYOU1/HERPUD1/EIF2S1/ERN1/ERP29/HSP90AA1/UBXN1/SSR1/DNAJC10/DDIT3/DERL1/MAP3K5/UBE4B/TRAM1L1/VCP/DDOST/LMAN1L/SEC24B/STT3B/UBE2D3/UBE2G2/HSP90AB1/PRKCSH/DNAJA2/BAK1/WFS1/TUSC3/HSPA5/CRYAB/CUL1	39
KEGG	hsa05418	Fluid shear stress and atherosclerosis	33/1160	139/8135	0.001783	0.03711	0.03272	ITGB3/ACVR1/KEAP1/MAPK11/HSP90B1/SQSTM1/CAV2/TNF/JUN/IL1R1/HSP90AA1/SDC2/FOS/GSTT2/GSTT1/NOS3/ACVR2A/MAP3K5/RELA/ASS1/MMP9/PIK3CD/PLAT/GSTM5/CALML4/IL1B/GPC1/DUSP1/CDH5/HSP90AB1/CAV1/KDR/NQO1	33
KEGG	hsa04657	IL-17 signaling pathway	24/1160	94/8135	0.002632	0.05156	0.04547	CXCL5/JUND/TNFAIP3/FOSB/FADD/NFKBIA/MAPK11/HSP90B1/TNF/JUN/MMP1/LCN2/TRAF4/HSP90AA1/FOS/TRAF6/RELA/CXCL6/MMP3/MMP9/IL1B/IL17D/CXCL1/HSP90AB1	24
KEGG	hsa05144	Malaria	15/1160	50/8135	0.003153	0.05651	0.04984	HBB/CR1L/GYPB/TNF/TGFB2/TGFB1/SELP/SDC2/THBS4/ITGAL/IL12A/THBS3/IL1B/TLR9/GYPA	15
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1160	106/8135	0.003261	0.05651	0.04984	ADCY3/ARAF/SLC9A3R1/ITPR1/JUND/MEF2D/PRKCB/ADCY7/ADCY4/RXRB/CREB1/AKAP13/RAF1/PDE4B/FOS/EGFR/ADCY6/PLCB2/PTH1R/PLCB1/CREB3L1/NR4A2/KL/LRP5/MMP25/NACA	26
KEGG	hsa05414	Dilated cardiomyopathy	24/1160	96/8135	0.00354	0.05651	0.04984	ITGB3/ADCY3/ITGB5/ITGA4/CACNA2D2/ADCY7/TNF/TGFB2/TGFB1/TPM1/ADCY4/CACNB3/ITGA7/SGCD/ADCY6/ITGA9/IGF1/ITGA3/CACNA2D3/ITGB8/SGCB/RYR2/ITGA2/DMD	24
KEGG	hsa04668	TNF signaling pathway	27/1160	112/8135	0.003564	0.05651	0.04984	CXCL5/TNFAIP3/FADD/BAG4/NFKBIA/MAPK11/CSF1/IRF1/TNF/JUN/VEGFC/CREB1/ITCH/MAP3K14/CX3CL1/FOS/MAP3K5/RELA/CXCL6/MMP3/MMP9/PIK3CD/CREB3L1/IL1B/CXCL1/RPS6KA5/JUNB	27
KEGG	hsa05163	Human cytomegalovirus infection	47/1160	225/8135	0.003841	0.05672	0.05002	ITGB3/ADCY3/ITPR1/FADD/NFKBIA/MAPK11/PRKCB/ADCY7/TNF/CRKL/IL1R1/PDIA3/ADCY4/CREB1/AKAP13/CCND1/CX3CL1/RAF1/GNG11/NFATC4/PTGER4/EGFR/JAK1/ADCY6/RELA/CXCL12/PLCB2/GNB3/PLCB1/HLA-B/PDGFRA/PIK3CD/BCAR1/CREB3L1/CALML4/IL1B/PPP3CB/GNG12/SOS2/IL10RA/MTOR/BAK1/GNGT2/ARHGEF12/GNG10/HLA-A/NFATC3	47
KEGG	hsa05133	Pertussis	20/1160	76/8135	0.003984	0.05672	0.05002	C1QB/C1QA/CXCL5/C1QC/IRF8/MAPK11/IRF1/TNF/JUN/C2/FOS/SERPING1/TRAF6/RELA/CXCL6/IL12A/C1R/CALML4/IL1B/C1S	20
KEGG	hsa03013	Nucleocytoplasmic transport	26/1160	108/8135	0.004274	0.05672	0.05002	SRRM1/NXF3/NXT1/NUP93/IPO9/THOC2/IPO7/DDX19A/NUP50/KPNA1/EEF1A1/NUP153/NUP210/KPNA3/RAE1/NUP188/NUP160/NUP54/NXF1/NUP214/NUP155/NUP210L/RANGAP1/TNPO3/IPO5/KPNA4	26
KEGG	hsa04662	B cell receptor signaling pathway	21/1160	82/8135	0.004552	0.05672	0.05002	INPP5D/NFKBIB/NFKBIA/PRKCB/JUN/BCL10/LILRA4/NFKBIE/FCGR2B/RAF1/FOS/BTK/VAV1/LILRB5/RELA/PIK3CD/PPP3CB/VAV3/SOS2/LYN/NFATC3	21
KEGG	hsa05224	Breast cancer	33/1160	147/8135	0.004603	0.05672	0.05002	ARAF/NCOA3/HEYL/NFKB2/APC/JUN/WNT5B/TCF7L1/HES1/CCND1/JAG2/RAF1/IGF1R/FGF18/FOS/EGFR/IGF1/EGF/CSNK1A1/WNT9A/FZD10/PIK3CD/NOTCH1/NOTCH2/FZD5/WNT5A/SOS2/MTOR/BAK1/FZD4/NOTCH3/LRP5/NCOA1	33
KEGG	hsa05140	Leishmaniasis	20/1160	77/8135	0.004678	0.05672	0.05002	HLA-DPB1/CR1L/NFKBIB/MARCKSL1/ITGA4/NFKBIA/MAPK11/PRKCB/TNF/JUN/TGFB2/TGFB1/FCGR3B/FOS/TRAF6/JAK1/RELA/EEF1A1/IL12A/IL1B	20
KEGG	hsa04015	Rap1 signaling pathway	44/1160	210/8135	0.004769	0.05672	0.05002	ITGB3/ADCY3/MAPK11/CSF1/PARD3/PRKCB/ADCY7/PARD6G/FLT1/CRKL/VEGFC/ADCY4/RASSF5/RAF1/IGF1R/FGF18/RAPGEF3/EGFR/VAV1/ADCY6/LPAR4/IGF1/PLCB2/EGF/PLCB1/PDGFRA/PIK3CD/ITGAL/PFN4/BCAR1/ENAH/PDGFRB/CALML4/TEK/RAPGEF5/ANGPT2/VAV3/MAGI2/PARD6A/RGS14/KDR/PFN1/RAPGEF4/PARD6B	44
KEGG	hsa04919	Thyroid hormone signaling pathway	28/1160	121/8135	0.005592	0.06262	0.05522	ITGB3/PDPK1/NCOA3/EP300/PRKCB/ATP1B2/RXRB/PFKFB2/CCND1/RCAN2/CREBBP/RAF1/THRB/MED13/PLCB2/PLCB1/PIK3CD/MED30/NOTCH1/DIO2/NOTCH2/PLCD4/NCOA2/MTOR/NOTCH3/SIN3A/PFKP/NCOA1	28
KEGG	hsa04350	TGF-beta signaling pathway	23/1160	94/8135	0.005641	0.06262	0.05522	LTBP1/ACVR1/RGMA/INHBA/EP300/TNF/SMAD7/PPP2CA/TGFB2/TGFB1/CREBBP/SMAD1/BMP2/ACVR2A/TGIF2/INHBE/GREM2/BMP8A/CDKN2B/DCN/FBN1/FMOD/CUL1	23
KEGG	hsa05410	Hypertrophic cardiomyopathy	22/1160	90/8135	0.006779	0.07282	0.06423	ITGB3/ITGB5/ITGA4/CACNA2D2/TNF/TGFB2/TGFB1/TPM1/CACNB3/ACE/ITGA7/SGCD/ITGA9/IGF1/ITGA3/CACNA2D3/PRKAG2/ITGB8/SGCB/RYR2/ITGA2/DMD	22
KEGG	hsa04530	Tight junction	36/1160	169/8135	0.007711	0.08024	0.07077	MYL9/CD1C/CTTN/SLC9A3R1/CLDN5/MPP5/MYL6B/PARD3/RAB13/PARD6G/JUN/DLG1/PPP2CA/CCND1/DLG2/CD1B/CLDN11/JAM2/MAP3K5/MAP3K1/MSN/WHAMM/ACTN1/AMOTL2/PRKAG2/MYH9/MPDZ/TJP1/PARD6A/ARPC2/HCLS1/MYH10/RAB8A/CGNL1/CLDN10/PARD6B	36
KEGG	hsa05142	Chagas disease	24/1160	102/8135	0.007964	0.08036	0.07088	C1QB/C1QA/C1QC/FADD/NFKBIA/MAPK11/TNF/JUN/PPP2CA/TGFB2/TGFB1/ACE/BDKRB2/FOS/TRAF6/RELA/PLCB2/PLCB1/PIK3CD/IL12A/IL2/IL1B/TLR9/GNA14	24
KEGG	hsa04010	MAPK signaling pathway	57/1160	294/8135	0.008333	0.08047	0.07097	MKNK2/PLA2G4C/ARAF/NTF3/JUND/BDNF/NFKB2/MAPK11/CSF1/PRKCB/CACNA2D2/TNF/FLT1/JUN/DUSP10/TGFB2/CRKL/VEGFC/IL1R1/TGFB1/CACNB3/MAP3K14/RAF1/IGF1R/FGF18/FOS/MAX/DDIT3/TRAF6/MAP3K2/EGFR/NTRK2/HSPB1/MAP3K5/MAP3K1/IGF1/RELA/EGF/PDGFRA/STK4/CACNA2D3/PPM1A/PDGFRB/IL1B/FLNC/TEK/ANGPT2/PPP3CB/FLNA/GNG12/SOS2/DUSP1/MAP3K3/MAPKAPK5/KDR/RPS6KA5/NFATC3	57
KEGG	hsa04935	Growth hormone synthesis, secretion and action	27/1160	119/8135	0.008458	0.08047	0.07097	ADCY3/ITPR1/EP300/MAPK11/PRKCB/ADCY7/GHRL/CRKL/ADCY4/CREB1/CREBBP/RAF1/FOS/ADCY6/MAP3K1/IGF1/PLCB2/PLCB1/IRS2/PIK3CD/BCAR1/CREB3L1/SOS2/MTOR/GHR/JUNB/IGFBP3	27
KEGG	hsa01522	Endocrine resistance	23/1160	98/8135	0.009556	0.0884	0.07796	ADCY3/ARAF/NCOA3/MAPK11/ADCY7/JUN/ADCY4/CCND1/CDKN2C/JAG2/RAF1/IGF1R/FOS/EGFR/ADCY6/IGF1/MMP9/PIK3CD/NOTCH1/NOTCH2/SOS2/MTOR/NOTCH3	23
KEGG	hsa05323	Rheumatoid arthritis	22/1160	93/8135	0.01011	0.08929	0.07874	CXCL5/HLA-DPB1/ATP6V1E1/CSF1/TNF/FLT1/JUN/TGFB2/MMP1/TGFB1/ATP6V0A2/ATP6V1G3/FOS/CXCL12/CXCL6/MMP3/TNFRSF11A/ITGAL/ACP5/IL1B/TEK/CXCL1	22
KEGG	hsa04625	C-type lectin receptor signaling pathway	24/1160	104/8135	0.01019	0.08929	0.07874	ITPR1/NFKB2/NFKBIA/MAPK11/IRF1/TNF/JUN/BCL10/MAP3K14/RAF1/NFATC4/CYLD/RELA/PIK3CD/IL12A/IL2/PLK3/CALML4/IL1B/IL17D/PPP3CB/ARHGEF12/LSP1/NFATC3	24
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1160	89/8135	0.01215	0.1037	0.09148	NFKBIB/NFKBIA/MAPK11/JUN/NFKBIE/BATF2/RAF1/FOS/TRAF6/EGFR/BATF/JAK1/RELA/EGF/PIK3CD/PPP3CB/TLR9/MAP3K3/MTOR/BATF3/NFATC3	21
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	44/1160	222/8135	0.01304	0.1085	0.0957	ADCY3/HLA-DPB1/POLB/EP300/NFKB2/NFKBIA/SLC25A5/ADCY7/TNF/JUN/DLG1/TGFB2/IL1R1/TGFB1/ADCY4/CREB1/ZFP36/NRP1/CCND1/MAP3K14/CDKN2C/CREBBP/TRRAP/FOS/NFATC4/BCL2L1/JAK1/ADCY6/MAP3K1/RELA/SLC25A6/BUB1B/HLA-B/PIK3CD/ITGAL/ANAPC10/IL2/CREB3L1/CDKN2B/PPP3CB/MSX1/MAP3K3/HLA-A/NFATC3	44
KEGG	hsa04916	Melanogenesis	23/1160	101/8135	0.01375	0.1105	0.0975	ADCY3/CAMK2G/EDNRB/ASIP/EP300/PRKCB/ADCY7/WNT5B/TCF7L1/ADCY4/CREB1/CREBBP/RAF1/ADCY6/PLCB2/PLCB1/WNT9A/FZD10/CREB3L1/CALML4/FZD5/WNT5A/FZD4	23
KEGG	hsa03010	Ribosome	33/1160	158/8135	0.01394	0.1105	0.0975	RPS27/RPS28/MRPL36/RPS27L/RPS15/UBA52/RPS26/RPLP1/RPL28/RPS3A/FAU/MRPL15/MRPL20/RPL10/RPL29/RSL24D1/MRPS14/RPS8/RPS4Y1/RPS2/RPL39/RPS10/MRPL18/RPL6/MRPL13/MRPL21/MRPL17/RPL14/RPS7/RPL22L1/RPL9/MRPL2/RPL15	33
KEGG	hsa04713	Circadian entrainment	22/1160	97/8135	0.01647	0.1276	0.1125	ADCY3/CAMK2G/ITPR1/PRKCB/ADCY7/ADCY4/CREB1/GNG11/FOS/GRIA3/ADCY6/PLCB2/GNB3/PLCB1/CALML4/RYR2/GNG12/ADCYAP1/GNGT2/RPS6KA5/PER1/GNG10	22
KEGG	hsa04974	Protein digestion and absorption	23/1160	103/8135	0.01727	0.1307	0.1153	COL9A2/MME/COL6A1/ATP1B2/COL10A1/COL16A1/COL18A1/ELN/COL27A1/COL4A1/SLC1A1/COL4A2/SLC7A9/COL14A1/COL5A1/COL12A1/COL21A1/COL6A2/COL17A1/CPA2/PRSS2/COL5A2/COL1A2	23
KEGG	hsa04660	T cell receptor signaling pathway	23/1160	104/8135	0.01928	0.1427	0.1259	PDPK1/NFKBIB/NFKBIA/MAPK11/TNF/JUN/DLG1/BCL10/NFKBIE/MAP3K14/RAF1/FOS/VAV1/RELA/PAK4/PIK3CD/IL2/PPP3CB/VAV3/PAK3/SOS2/PTPRC/NFATC3	23
KEGG	hsa04371	Apelin signaling pathway	29/1160	139/8135	0.02055	0.1487	0.1312	TFAM/ADCY3/MAP1LC3A/ITPR1/MEF2D/MYL4/ADCY7/ADCY4/CCND1/RAF1/GNG11/SPP1/NOS3/ADCY6/PLCB2/GNB3/PLCB1/AGTR1/PLAT/APLNR/PRKAG2/CALML4/RYR2/GNG12/MTOR/GNGT2/ACTA2/GNG10/NOTCH3	29
KEGG	hsa04270	Vascular smooth muscle contraction	28/1160	134/8135	0.02214	0.1568	0.1383	ADCY3/MYL9/PLA2G4C/ARAF/ITPR1/MYL6B/PRKCB/ADCY7/ADCY4/ACTG2/PLA2G5/RAF1/CALD1/EDN3/CALCRL/ADCY6/PLCB2/RAMP2/PLCB1/AGTR1/KCNMA1/RAMP3/CALML4/MYH9/PLA2G2A/MYH10/ACTA2/ARHGEF12	28
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1160	100/8135	0.02304	0.1599	0.141	MAPK11/PRKCB/TNF/JUN/TGFB2/VEGFC/TGFB1/CCND1/DIAPH1/FN1/NOS3/RELA/PLCB2/COL4A1/PLCB1/COL4A2/PIK3CD/AGTR1/IL1B/PLCD4/NOX4/COL1A2	22
KEGG	hsa05131	Shigellosis	46/1160	247/8135	0.03195	0.2171	0.1915	RRAGA/MYL9/CTTN/MAP1LC3A/ITPR1/NFKBIB/CASP4/ARF1/NFKBIA/MAPK11/WASF2/SQSTM1/TNF/JUN/BCL10/CRKL/IL1R1/TECPR1/UBA52/TNIP1/U2AF1L4/PPID/DIAPH1/TRAF6/EGFR/BCL2L1/FNBP1L/RELA/PLCB2/U2AF1/PLCB1/PIK3CD/PFN4/ACTN1/WASF1/BCAR1/IL1B/PLCD4/UBC/UBE2D3/ARPC2/HCLS1/MTOR/RPS6KA5/PFN1/CUL1	46
KEGG	hsa05222	Small cell lung cancer	20/1160	92/8135	0.03292	0.2193	0.1934	NFKBIA/LAMC1/RXRB/TRAF4/CCND1/FN1/LAMC2/MAX/TRAF6/BCL2L1/RELA/ITGA3/COL4A1/COL4A2/PIK3CD/CDKN2B/LAMB1/SKP2/BAK1/ITGA2	20
KEGG	hsa05231	Choline metabolism in cancer	21/1160	98/8135	0.0339	0.2214	0.1952	PLA2G4C/PDPK1/WASF3/WASF2/PRKCB/JUN/RAF1/FOS/EGFR/EGF/PDGFRA/DGKD/PIK3CD/WASF1/PDGFRB/SOS2/DGKZ/SLC44A3/MTOR/SLC44A2/PCYT1A	21
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1160	77/8135	0.04097	0.2624	0.2314	ITGB3/ITGB5/ITGA4/CACNA2D2/TCF7L1/CACNB3/ITGA7/SGCD/JUP/ITGA9/ITGA3/CACNA2D3/ITGB8/SGCB/RYR2/ITGA2/DMD	17
KEGG	hsa04211	Longevity regulating pathway	19/1160	89/8135	0.04362	0.2741	0.2417	ADCY3/PPARG/ADCY7/ADCY4/CREB1/IGF1R/SIRT1/SESN2/ADCY6/IGF1/RELA/ADIPOR2/IRS2/PIK3CD/SESN3/CREB3L1/PRKAG2/MTOR/KL	19
KEGG	hsa04068	FoxO signaling pathway	26/1160	131/8135	0.04736	0.2921	0.2576	GABARAPL2/ARAF/PDPK1/EP300/MAPK11/TGFB2/TGFB1/CCND1/CREBBP/RAF1/IGF1R/USP7/SIRT1/EGFR/IGF1/EGF/IRS2/STK4/PIK3CD/PLK3/PLK1/PRKAG2/CDKN2B/SKP2/FBXO25/SOS2	26
KEGG	hsa04670	Leukocyte transendothelial migration	23/1160	114/8135	0.05078	0.3022	0.2665	MYL9/CLDN5/ITGA4/MAPK11/PRKCB/ESAM/RASSF5/RAPGEF3/CLDN11/VAV1/JAM2/CXCL12/MSN/MMP9/PIK3CD/ITGAL/ACTN1/BCAR1/THY1/VAV3/CDH5/CLDN10/RAPGEF4	23
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/1160	79/8135	0.05082	0.3022	0.2665	ARAF/PRKCB/GAS6/RAF1/IGF1R/EGFR/BCL2L1/JAK1/IGF1/EGF/PDGFRA/PIK3CD/PDGFRB/SOS2/MTOR/KDR/AXL	17
KEGG	hsa03015	mRNA surveillance pathway	20/1160	97/8135	0.05391	0.3095	0.273	CPSF7/SRRM1/NXF3/PABPC4/PELO/PPP2R3C/NXT1/PAPOLA/PPP2CA/FUS/DDX19A/PABPC3/PPP2R5E/PABPN1/NXF1/PCF11/PABPC4L/SMG6/RNGTT/RNMT	20
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	20/1160	97/8135	0.05391	0.3095	0.273	PLA2G4C/AMPH/INPP5D/MARCKSL1/WASF3/WASF2/ASAP2/PRKCB/CRKL/ASAP3/FCGR2B/FCGR3B/RAF1/VAV1/PIK3CD/WASF1/VAV3/ARPC2/LYN/PTPRC	20
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	36/1160	194/8135	0.05533	0.3097	0.2732	MAP1LC3A/ITPR1/FADD/EP300/NFKBIA/MAPK11/JUN/TCF7L1/CREB1/ZFP36/UBA52/CCND1/CREBBP/RAF1/GNG11/FOS/NFATC4/JAK1/RELA/GNB3/HLA-B/CLEC2B/PIK3CD/CALML4/ANGPT2/PPP3CB/UBC/CXCL1/GNG12/MTOR/LYN/BAK1/GNGT2/GNG10/HLA-A/NFATC3	36
KEGG	hsa05219	Bladder cancer	10/1160	41/8135	0.05805	0.3097	0.2732	ARAF/RASSF1/MMP1/CCND1/RAF1/EGFR/DAPK2/EGF/MMP9/RPS6KA5	10
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	20/1160	98/8135	0.05904	0.3097	0.2732	ADCY3/PLA2G4C/CAMK2G/ITPR1/MAPK11/PRKCB/ADCY7/IL1R1/ADCY4/BDKRB2/PTGER4/ADCY6/IGF1/PLCB2/PLCB1/P2RY2/PIK3CD/HRH1/CALML4/IL1B	20
KEGG	hsa04925	Aldosterone synthesis and secretion	20/1160	98/8135	0.05904	0.3097	0.2732	ADCY3/CYP11A1/CAMK2G/ITPR1/DAGLB/PRKCB/ADCY7/ATP1B2/ADCY4/CREB1/PDE2A/CYP21A2/ADCY6/PLCB2/PLCB1/AGTR1/KCNK3/CREB3L1/CALML4/NR4A2	20
KEGG	hsa04924	Renin secretion	15/1160	69/8135	0.05925	0.3097	0.2732	ITPR1/CREB1/ACE/PTGER4/EDN3/ADCY6/PLCB2/PLCB1/AGTR1/KCNMA1/AQP1/CALML4/PDE1A/PPP3CB/ADCYAP1	15
KEGG	hsa04064	NF-kappa B signaling pathway	21/1160	104/8135	0.05953	0.3097	0.2732	TNFAIP3/NFKB2/NFKBIA/PRKCB/TNF/BCL10/IL1R1/MAP3K14/BTK/TRAF6/CCL13/BCL2L1/CYLD/RELA/CXCL12/CARD10/TNFRSF11A/IL1B/CCL21/CXCL1/LYN	21
KEGG	hsa05214	Glioma	16/1160	75/8135	0.06091	0.312	0.2752	ARAF/CAMK2G/PRKCB/CCND1/RAF1/IGF1R/EGFR/IGF1/EGF/PDGFRA/PIK3CD/PDGFRB/CALML4/SOS2/MTOR/BAK1	16
KEGG	hsa05417	Lipid and atherosclerosis	39/1160	215/8135	0.06386	0.318	0.2804	PDPK1/CAMK2G/ITPR1/PPARG/NFKBIA/MAPK11/HSP90B1/TNF/JUN/MMP1/RXRB/SELP/EIF2S1/ERN1/HSP90AA1/FOS/DDIT3/TRAF6/BCL2L1/NOS3/VAV1/MAP3K5/RELA/PLCB2/PLCB1/MMP3/MMP9/PIK3CD/IL12A/CALML4/IL1B/PPP3CB/CXCL1/VAV3/POU2F2/HSP90AB1/LYN/HSPA5/NFATC3	39
KEGG	hsa04912	GnRH signaling pathway	19/1160	93/8135	0.06397	0.318	0.2804	ADCY3/PLA2G4C/CAMK2G/ITPR1/MAPK11/PRKCB/ADCY7/JUN/ADCY4/RAF1/MAP3K2/EGFR/ADCY6/MAP3K1/PLCB2/PLCB1/CALML4/SOS2/MAP3K3	19
KEGG	hsa04120	Ubiquitin mediated proteolysis	27/1160	142/8135	0.06896	0.3377	0.2978	RHOBTB1/UBE2QL1/KEAP1/HERC1/UBA52/ITCH/FBXW7/FBXW8/FBXO4/TRAF6/HERC3/UBE2S/PML/MAP3K1/UBE4B/CBL/UBE3C/RCHY1/ANAPC10/MID1/FANCL/UBE2C/SKP2/UBC/UBE2D3/UBE2G2/CUL1	27
KEGG	hsa04022	cGMP-PKG signaling pathway	31/1160	167/8135	0.07099	0.3393	0.2992	ADCY3/MYL9/ITPR1/EDNRB/MEF2D/GTF2I/SLC25A5/ADCY7/ATP1B2/ADCY4/CREB1/PDE2A/ADRA2A/RAF1/BDKRB2/NFATC4/GTF2IRD1/NOS3/ADCY6/SLC25A6/PLCB2/PLCB1/IRS2/AGTR1/KCNMA1/CREB3L1/KCNJ8/CALML4/PPP3CB/NFATC3/ADORA3	31
KEGG	hsa04927	Cortisol synthesis and secretion	14/1160	65/8135	0.07133	0.3393	0.2992	ADCY3/CYP11A1/ITPR1/PBX1/ADCY7/ADCY4/CREB1/CYP21A2/ADCY6/PLCB2/PLCB1/AGTR1/KCNK3/CREB3L1	14
KEGG	hsa05152	Tuberculosis	33/1160	180/8135	0.07374	0.3459	0.305	HLA-DPB1/CR1L/CAMK2G/FADD/EP300/MAPK11/TNF/BCL10/TGFB2/TGFB1/CREB1/FCGR2B/ATP6V0A2/CREBBP/NFYA/FCGR3B/RAF1/MRC2/CAMP/TRAF6/JAK1/RELA/IL12A/PLK3/CALML4/IL1B/PPP3CB/TLR9/IL10RA/ARHGEF12/CORO1A/LSP1/HSPA9	33
KEGG	hsa05225	Hepatocellular carcinoma	31/1160	168/8135	0.07568	0.3468	0.3058	ARID1A/ARAF/ARID1B/KEAP1/APC/PRKCB/TGFB2/WNT5B/TGFB1/TCF7L1/CCND1/SMARCC1/RAF1/IGF1R/GSTT2/EGFR/GSTT1/BCL2L1/CSNK1A1/WNT9A/FZD10/PIK3CD/GSTM5/FZD5/WNT5A/SOS2/MTOR/BAK1/FZD4/LRP5/NQO1	31
KEGG	hsa04722	Neurotrophin signaling pathway	23/1160	119/8135	0.07602	0.3468	0.3058	SH2B3/NTF3/PDPK1/CAMK2G/NFKBIB/BDNF/NFKBIA/MAPK11/JUN/CRKL/NFKBIE/RAF1/TRAF6/NTRK2/MAP3K5/MAP3K1/RELA/PIK3CD/FRS2/CALML4/SOS2/MAP3K3/RPS6KA5	23
KEGG	hsa04150	mTOR signaling pathway	29/1160	156/8135	0.07753	0.3489	0.3077	GRB10/RRAGA/PDPK1/ATP6V1E1/DEPDC5/PRKCB/EIF4B/TNF/STRADB/WNT5B/FLCN/RAF1/ATP6V1G3/IGF1R/TELO2/SESN2/ULK2/IGF1/WNT9A/FZD10/PIK3CD/FZD5/SKP2/WNT5A/SOS2/MTOR/FZD4/MAPKAP1/LRP5	29
KEGG	hsa04390	Hippo signaling pathway	29/1160	157/8135	0.08272	0.3579	0.3157	RASSF1/MPP5/APC/PARD3/PARD6G/SMAD7/DLG1/PPP2CA/TGFB2/WNT5B/TGFB1/TCF7L1/CCND1/DLG2/SMAD1/BMP2/WWTR1/YWHAZ/WNT9A/FZD10/TEAD4/BMP8A/YAP1/FZD5/WNT5A/PARD6A/TP53BP2/FZD4/PARD6B	29
KEGG	hsa04659	Th17 cell differentiation	21/1160	108/8135	0.08274	0.3579	0.3157	HLA-DPB1/NFKBIB/NFKBIA/MAPK11/JUN/IL1R1/NFKBIE/TGFB1/RXRB/HSP90AA1/IRF4/FOS/IL23R/JAK1/RELA/IL2/IL1B/PPP3CB/HSP90AB1/MTOR/NFATC3	21
KEGG	hsa00910	Nitrogen metabolism	5/1160	17/8135	0.08277	0.3579	0.3157	CA1/CA4/CA14/CA12/CPS1	5
KEGG	hsa04130	SNARE interactions in vesicular transport	8/1160	33/8135	0.08763	0.3731	0.3291	STX2/STX16/STX8/BET1/SNAP23/GOSR1/STX4/BNIP1	8
KEGG	hsa05164	Influenza A	31/1160	171/8135	0.09104	0.3731	0.3291	HLA-DPB1/NXF3/FADD/NFKBIB/EP300/NFKBIA/NXT1/SLC25A5/PRKCB/TNF/EIF2S1/CREBBP/RAF1/TPSAB1/KPNA1/IFIH1/JAK1/PML/RELA/SLC25A6/PABPN1/RAE1/PIK3CD/IL12A/NXF1/HNRNPUL1/IL1B/IL33/BAK1/PRSS2/RSAD2	31
KEGG	hsa03040	Spliceosome	27/1160	147/8135	0.0965	0.3731	0.3291	TRA2B/PHF5A/SF3B2/SF3B5/LSM4/RBM22/PPIL1/SYF2/DDX42/HNRNPM/THOC2/LSM7/FUS/WBP11/PRPF38B/SF3B4/U2AF1L4/PQBP1/U2AF1/TRA2A/HNRNPK/SNRPB/SF3B1/RBMX/SMNDC1/CDC5L/DDX46	27
KEGG	hsa04140	Autophagy - animal	26/1160	141/8135	0.09782	0.3731	0.3291	RRAGA/GABARAPL2/MAP1LC3A/PDPK1/ITPR1/EIF2AK4/SQSTM1/PPP2CA/EIF2S1/ERN1/RAF1/IGF1R/TRAF6/BCL2L1/SMCR8/ULK2/DAPK2/ATG4B/MTMR14/IRS2/PIK3CD/RAB7B/UVRAG/MTOR/RAB8A/MTMR4	26
KEGG	hsa04658	Th1 and Th2 cell differentiation	18/1160	92/8135	0.09786	0.3731	0.3291	MAF/HLA-DPB1/NFKBIB/NFKBIA/MAPK11/JUN/NFKBIE/JAG2/FOS/JAK1/RELA/IL12A/IL2/NOTCH1/NOTCH2/PPP3CB/NOTCH3/NFATC3	18
KEGG	hsa05210	Colorectal cancer	17/1160	86/8135	0.09799	0.3731	0.3291	PMAIP1/ARAF/MSH6/APC/JUN/TGFB2/TGFB1/TCF7L1/CCND1/RAF1/FOS/EGFR/EGF/PIK3CD/SOS2/MTOR/BAK1	17
KEGG	hsa03060	Protein export	6/1160	23/8135	0.09815	0.3731	0.3291	SEC62/SEC61B/SPCS1/SPCS3/HSPA5/SRP54	6
KEGG	hsa05132	Salmonella infection	43/1160	249/8135	0.101	0.3731	0.3291	MYL9/FADD/CASP4/ARF1/WASF3/NFKBIA/MAPK11/HSP90B1/TNF/JUN/DYNC1I1/TCF7L1/ACTR10/HSP90AA1/RAF1/FOS/KPNA1/TRAF6/RELA/FYCO1/KPNA3/RHOJ/PIK3CD/PFN4/AHNAK/RAB7B/DYNLRB1/IL1B/FLNC/NCKAP1/PAK3/FLNA/TLR9/PODXL/ARPC2/HSP90AB1/BAK1/DYNLL2/KPNA4/PFN1/DCTN4/PTPRC/KLC1	43
KEGG	hsa04921	Oxytocin signaling pathway	28/1160	154/8135	0.1012	0.3731	0.3291	ADCY3/MYL9/PLA2G4C/CAMK2G/ITPR1/MYL6B/PRKCB/CACNA2D2/ADCY7/JUN/ADCY4/CACNB3/CCND1/RAF1/FOS/NFATC4/EGFR/NOS3/ADCY6/PLCB2/PLCB1/CACNA2D3/PRKAG2/CALML4/PPP3CB/OXTR/RYR2/NFATC3	28
KEGG	hsa04062	Chemokine signaling pathway	34/1160	192/8135	0.1027	0.3731	0.3291	ADCY3/CXCL5/NFKBIB/NFKBIA/PARD3/PRKCB/ADCY7/CRKL/ADCY4/CX3CL1/RAF1/CXCR1/GNG11/CCL13/VAV1/ADCY6/RELA/CXCL12/PLCB2/GNB3/CXCL6/PLCB1/PIK3CD/BCAR1/CCL21/CXCL1/VAV3/CCL8/GNG12/SOS2/LYN/GNGT2/GNG10/CCL18	34
KEGG	hsa04072	Phospholipase D signaling pathway	27/1160	148/8135	0.1028	0.3731	0.3291	ADCY3/PLA2G4C/ARF1/ADCY7/LPAR6/ADCY4/FCER1A/RAF1/CXCR1/RAPGEF3/EGFR/ADCY6/LPAR4/PLCB2/EGF/PTGFR/PLCB1/PDGFRA/DGKD/PIK3CD/AGTR1/DNM1/PDGFRB/SOS2/DGKZ/MTOR/RAPGEF4	27
KEGG	hsa05134	Legionellosis	12/1160	57/8135	0.1037	0.3731	0.3291	CR1L/ARF1/NFKB2/NFKBIA/CLK1/TNF/RELA/EEF1A1/VCP/IL12A/IL1B/CXCL1	12
KEGG	hsa04310	Wnt signaling pathway	30/1160	167/8135	0.1041	0.3731	0.3291	CAMK2G/EP300/APC/PRKCB/JUN/WNT5B/TCF7L1/DAAM2/CCND1/CREBBP/GPC4/NFATC4/SFRP2/PLCB2/CSNK1A1/PLCB1/WNT9A/FZD10/SFRP4/RSPO3/SFRP1/PPP3CB/FZD5/WNT5A/ROR1/FZD4/LRP5/PRICKLE2/NFATC3/CUL1	30
KEGG	hsa04936	Alcoholic liver disease	26/1160	142/8135	0.1043	0.3731	0.3291	C1QB/C1QA/TRA2B/C1QC/FADD/NFKBIA/MAPK11/CPT1C/TNF/TCF7L1/C2/CCND1/MAP3K14/SIRT1/TRAF6/MAP3K5/RELA/ADIPOR2/TRA2A/IL12A/PRKAG2/IL1B/CXCL1/NOX4/ALDH7A1/ADH1C	26
KEGG	hsa04640	Hematopoietic cell lineage	19/1160	99/8135	0.1054	0.3731	0.3291	ITGB3/CD1C/MME/HLA-DPB1/CR1L/ITGA4/CSF1/CD9/TNF/CD59/IL1R1/CD1B/CD37/ITGA3/CD34/IL1B/GYPA/ITGA2/GP1BA	19
KEGG	hsa05031	Amphetamine addiction	14/1160	69/8135	0.1061	0.3731	0.3291	SLC18A1/CAMK2G/FOSB/PRKCB/JUN/CREB1/MAOA/FOS/SIRT1/GRIA3/CREB3L1/CALML4/PPP3CB/ARC	14
KEGG	hsa03320	PPAR signaling pathway	15/1160	75/8135	0.1065	0.3731	0.3291	PDPK1/PPARG/ME1/CPT1C/FABP5/LPL/MMP1/RXRB/ANGPTL4/SORBS1/UBC/HMGCS1/ME3/PLTP/FABP3	15
KEGG	hsa04918	Thyroid hormone synthesis	15/1160	75/8135	0.1065	0.3731	0.3291	ADCY3/ITPR1/PRKCB/HSP90B1/ADCY7/ATP1B2/ADCY4/CREB1/ADCY6/PLCB2/PLCB1/CREB3L1/GPX8/TTF1/HSPA5	15
KEGG	hsa04934	Cushing syndrome	28/1160	155/8135	0.1076	0.3731	0.3291	ADCY3/CYP11A1/CAMK2G/ITPR1/APC/PBX1/ADCY7/WNT5B/TCF7L1/ADCY4/CREB1/CCND1/WDR5/CDKN2C/CYP21A2/EGFR/ADCY6/PLCB2/PLCB1/WNT9A/FZD10/AGTR1/KCNK3/CREB3L1/CDKN2B/FZD5/WNT5A/FZD4	28
KEGG	hsa04014	Ras signaling pathway	40/1160	232/8135	0.1124	0.386	0.3404	PLA2G4C/NTF3/RASSF1/BDNF/RGL1/CSF1/PRKCB/FLT1/VEGFC/PLA2G5/RASSF5/RAF1/IGF1R/FGF18/GNG11/REL/RASAL2/EGFR/BCL2L1/NTRK2/IGF1/RELA/GNB3/EGF/PAK4/PDGFRA/STK4/PIK3CD/PDGFRB/CALML4/PLA2G2A/TEK/RAPGEF5/ANGPT2/PAK3/GNG12/SOS2/KDR/GNGT2/GNG10	40
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1160	70/8135	0.1161	0.3946	0.348	ATP6V1E1/NFKBIA/MAPK11/JUN/MAP3K14/ATP6V0A2/ATP6V1G3/CXCR1/EGFR/JAM2/RELA/CXCL1/TJP1/LYN	14
KEGG	hsa04915	Estrogen signaling pathway	25/1160	138/8135	0.12	0.4035	0.3559	ADCY3/NCOA3/ITPR1/HSP90B1/ADCY7/JUN/FKBP4/ADCY4/CREB1/HSP90AA1/RAF1/FOS/EGFR/NOS3/ADCY6/PLCB2/PLCB1/MMP9/PIK3CD/CREB3L1/CALML4/NCOA2/SOS2/HSP90AB1/NCOA1	25
KEGG	hsa04520	Adherens junction	14/1160	71/8135	0.1267	0.4219	0.3721	EP300/WASF3/WASF2/PARD3/TCF7L1/CREBBP/IGF1R/EGFR/PTPRF/ACTN1/WASF1/SORBS1/TJP1/PTPRB	14
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	8/1160	36/8135	0.1309	0.4315	0.3805	SIRT2/SIRT1/NNMT/QPRT/NADSYN1/AOX1/SIRT7/NMNAT3	8
KEGG	hsa05130	Pathogenic Escherichia coli infection	34/1160	197/8135	0.1332	0.4349	0.3835	CTTN/SLC9A3R1/CLDN5/FADD/NFKBIB/CASP4/ARF1/WASF3/NFKBIA/MAPK11/WASF2/TNF/JUN/IL1R1/FOS/CLDN11/TRAF6/LPAR4/RELA/SEC24B/WASF1/MYO1C/MYH9/IL1B/NCKAP1/PAK3/TJP1/ARPC2/HCLS1/BAK1/MYH10/ARHGEF12/CLDN10/MYO5C	34
KEGG	hsa05223	Non-small cell lung cancer	14/1160	72/8135	0.1378	0.4436	0.3913	ARAF/RASSF1/PDPK1/PRKCB/RXRB/RASSF5/CCND1/RAF1/EGFR/EGF/STK4/PIK3CD/SOS2/BAK1	14
KEGG	hsa04730	Long-term depression	12/1160	60/8135	0.1386	0.4436	0.3913	PLA2G4C/ARAF/ITPR1/PRKCB/PPP2CA/RAF1/IGF1R/GRIA3/IGF1/PLCB2/PLCB1/LYN	12
KEGG	hsa05143	African trypanosomiasis	8/1160	37/8135	0.1473	0.465	0.4101	HBB/PRKCB/TNF/PLCB2/PLCB1/IL12A/IL1B/TLR9	8
KEGG	hsa03018	RNA degradation	15/1160	79/8135	0.148	0.465	0.4101	LSM4/PABPC4/CNOT8/CNOT4/LSM7/DCP2/PABPC3/EXOSC3/BTG2/PABPC4L/CNOT7/HSPA9/DDX6/CNOT1/PFKP	15
KEGG	hsa04940	Type I diabetes mellitus	9/1160	43/8135	0.15	0.4666	0.4116	HLA-DPB1/TNF/ICA1/CPE/HLA-B/IL12A/IL2/IL1B/HLA-A	9
KEGG	hsa05030	Cocaine addiction	10/1160	49/8135	0.1513	0.4666	0.4116	SLC18A1/FOSB/BDNF/JUN/CREB1/MAOA/RELA/CREB3L1/CDK5R1/GPSM1	10
KEGG	hsa04514	Cell adhesion molecules	26/1160	149/8135	0.1571	0.4721	0.4164	NRCAM/HLA-DPB1/CLDN5/ITGA4/ESAM/SELP/CD276/L1CAM/SDC2/CLDN11/JAM2/ITGA9/PTPRF/HLA-B/ITGAL/PDCD1LG2/CD34/CADM3/ITGB8/CDH5/NLGN4X/SPN/NCAM2/PTPRC/CLDN10/HLA-A	26
KEGG	hsa05226	Gastric cancer	26/1160	149/8135	0.1571	0.4721	0.4164	ARAF/APC/TGFB2/WNT5B/TGFB1/TCF7L1/RXRB/CCND1/RAF1/FGF18/JUP/EGFR/EGF/CSNK1A1/WNT9A/FZD10/PIK3CD/CDKN2B/MUC2/FZD5/WNT5A/SOS2/MTOR/BAK1/FZD4/LRP5	26
KEGG	hsa04911	Insulin secretion	16/1160	86/8135	0.1574	0.4721	0.4164	ADCY3/CAMK2G/PRKCB/ADCY7/ATP1B2/ADCY4/CREB1/KCNN3/ADCY6/PLCB2/PLCB1/KCNMA1/CREB3L1/RYR2/ADCYAP1/RAPGEF4	16
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1160	143/8135	0.1603	0.4739	0.418	ACVR1/INHBA/APC/MAPK11/WNT5B/NANOG/SMAD1/RAF1/IGF1R/JAK1/ACVR2A/SKIL/IGF1/INHBE/WNT9A/FZD10/PIK3CD/LIFR/KLF4/JARID2/FZD5/REST/WNT5A/PCGF2/FZD4	25
KEGG	hsa04664	Fc epsilon RI signaling pathway	13/1160	68/8135	0.1634	0.4739	0.418	PLA2G4C/PDPK1/INPP5D/MAPK11/TNF/FCER1A/RAF1/BTK/VAV1/PIK3CD/VAV3/SOS2/LYN	13
KEGG	hsa04213	Longevity regulating pathway - multiple species	12/1160	62/8135	0.1649	0.4739	0.418	ADCY3/ADCY7/ADCY4/IGF1R/SIRT1/ADCY6/IGF1/IRS2/PIK3CD/PRKAG2/MTOR/CRYAB	12
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	26/1160	150/8135	0.1656	0.4739	0.418	ADCY3/SCN1B/CAMK2G/PPP2R3C/MAPK11/CACNA2D2/MYL4/ADCY7/PPP2CA/ATP1B2/TPM1/ADCY4/CREB1/CACNB3/RAPGEF3/PPP2R5E/ADCY6/PLCB2/PLCB1/AGTR1/CACNA2D3/CREB3L1/CALML4/RYR2/RPS6KA5/RAPGEF4	26
KEGG	hsa04340	Hedgehog signaling pathway	11/1160	56/8135	0.166	0.4739	0.418	EVC/GAS1/EVC2/CCND1/BOC/CSNK1A1/CDON/SMO/GLI3/SCUBE2/CUL1	11
KEGG	hsa00510	N-Glycan biosynthesis	10/1160	50/8135	0.1665	0.4739	0.418	B4GALT2/DOLK/DDOST/MAN2A2/MGAT2/STT3B/ALG14/MAN2A1/ST6GAL1/TUSC3	10
KEGG	hsa05211	Renal cell carcinoma	13/1160	69/8135	0.1767	0.4917	0.4337	ARAF/EP300/JUN/TGFB2/CRKL/TGFB1/FLCN/CREBBP/RAF1/PAK4/PIK3CD/PAK3/SOS2	13
KEGG	hsa03250	Viral life cycle - HIV-1	12/1160	63/8135	0.179	0.4917	0.4337	CPSF7/EP300/CDK9/SAMHD1/CREBBP/CHMP6/CCNT2/NUP153/SERINC3/TNPO3/ELL/PIN1	12
KEGG	hsa05217	Basal cell carcinoma	12/1160	63/8135	0.179	0.4917	0.4337	APC/WNT5B/TCF7L1/BMP2/WNT9A/FZD10/SMO/GLI3/FZD5/WNT5A/BAK1/FZD4	12
KEGG	hsa04540	Gap junction	16/1160	88/8135	0.1808	0.4917	0.4337	ADCY3/ITPR1/PRKCB/ADCY7/ADCY4/RAF1/MAP3K2/EGFR/ADCY6/PLCB2/EGF/PLCB1/PDGFRA/PDGFRB/TJP1/SOS2	16
KEGG	hsa03410	Base excision repair	7/1160	33/8135	0.1814	0.4917	0.4337	POLB/PARP3/POLE3/TDG/NEIL3/POLE/APEX2	7
KEGG	hsa00513	Various types of N-glycan biosynthesis	8/1160	39/8135	0.1831	0.4917	0.4337	B4GALT2/DDOST/MAN2A2/MGAT2/STT3B/ALG14/MAN2A1/TUSC3	8
KEGG	hsa04152	AMPK signaling pathway	21/1160	120/8135	0.1845	0.4917	0.4337	PDPK1/PPARG/PPP2R3C/CPT1C/PPP2CA/STRADB/PFKFB2/CREB1/CCND1/IGF1R/SIRT1/PPP2R5E/IGF1/ADIPOR2/IRS2/PIK3CD/CREB3L1/PRKAG2/MTOR/RAB8A/PFKP	21
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	75/1160	476/8135	0.1846	0.4917	0.4337	PSMD14/PSMD12/NDUFA10/ARAF/MAP1LC3A/CAMK2G/ITPR1/FADD/BDNF/APC/MAPK11/CSF1/SLC25A5/PRKCB/SNCA/SQSTM1/TNF/WNT5B/PSMD7/PINK1/PSMB5/ACTR10/FUS/NDUFA4L2/UBA52/EIF2S1/ERN1/PPID/NEFH/RAF1/DDIT3/GRIA3/BCL2L1/SMCR8/DERL1/UCHL1/ULK2/MAP3K5/RELA/SLC25A6/PLCB2/VCP/ATXN2L/CSNK1A1/PLCB1/COX7A1/WNT9A/FZD10/PSMB7/GPX8/CALML4/IL1B/PSMD1/PPP3CB/PSMD9/FZD5/CDK5R1/UBC/NOX4/WNT5A/COX8C/UBE2G2/RYR2/DNALI1/NDUFB2/MTOR/DNAH5/BAK1/FZD4/RAB8A/DNAH17/HSPA5/DCTN4/LRP5/KLC1	75
KEGG	hsa04622	RIG-I-like receptor signaling pathway	13/1160	70/8135	0.1905	0.5036	0.4441	FADD/NFKBIB/NFKBIA/MAPK11/TNF/TRAF6/IFIH1/CYLD/MAP3K1/RELA/IL12A/RNF125/PIN1	13
KEGG	hsa05014	Amyotrophic lateral sclerosis	58/1160	364/8135	0.1941	0.507	0.4472	PSMD14/PSMD12/NDUFA10/MAP1LC3A/NRG4/NXF3/NXT1/MAPK11/SQSTM1/TNF/NUP93/PSMD7/PINK1/PSMB5/ACTR10/FUS/NDUFA4L2/EIF2S1/ERN1/NEFH/MATR3/NUP50/DDIT3/BCL2L1/SMCR8/DERL1/ULK2/MAP3K5/NUP153/NUP210/VCP/ATXN2L/RAE1/NUP188/COX7A1/NUP160/NUP54/PFN4/NXF1/NUP214/NUP155/PSMB7/GPX8/PSMD1/PPP3CB/PSMD9/NUP210L/COX8C/DNALI1/NDUFB2/MTOR/DNAH5/RAB8A/DNAH17/PFN1/HSPA5/DCTN4/KLC1	58
KEGG	hsa00220	Arginine biosynthesis	5/1160	22/8135	0.1956	0.507	0.4472	ARG2/ARG1/NOS3/ASS1/CPS1	5
KEGG	hsa05213	Endometrial cancer	11/1160	58/8135	0.1964	0.507	0.4472	ARAF/PDPK1/APC/TCF7L1/CCND1/RAF1/EGFR/EGF/PIK3CD/SOS2/BAK1	11
KEGG	hsa05100	Bacterial invasion of epithelial cells	14/1160	77/8135	0.2009	0.5147	0.4539	CTTN/WASF2/CAV2/CRKL/ARHGAP10/FN1/CBL/PIK3CD/WASF1/DNM1/BCAR1/ARPC2/CAV1/HCLS1	14
KEGG	hsa04020	Calcium signaling pathway	39/1160	240/8135	0.2092	0.5317	0.469	ADCY3/CAMK2G/ITPR1/EDNRB/CYSLTR2/SLC25A5/PRKCB/ADCY7/MCOLN3/FLT1/VEGFC/ADCY4/TACR1/FGF18/BDKRB2/ASPH/EGFR/NTRK2/NOS3/P2RX7/SLC25A6/PLCB2/EGF/PTGFR/PLCB1/PDGFRA/AGTR1/HRH1/PDGFRB/CALML4/PLCD4/PDE1A/PPP3CB/OXTR/GNA14/RYR2/KDR/MST1/PHKA1	39
KEGG	hsa00120	Primary bile acid biosynthesis	4/1160	17/8135	0.216	0.5406	0.4768	HSD3B7/CH25H/AKR1D1/CYP39A1	4
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1160	53/8135	0.2161	0.5406	0.4768	PRKCB/ATP1B2/BDKRB2/AP2A2/ADCY6/PLCB2/PTH1R/PLCB1/DNM1/KL	10
KEGG	hsa04210	Apoptosis	23/1160	136/8135	0.2176	0.5406	0.4768	PMAIP1/PDPK1/ITPR1/FADD/PARP3/PTPN13/NFKBIA/TNF/JUN/EIF2S1/ERN1/MAP3K14/RAF1/FOS/DDIT3/BCL2L1/MAP3K5/RELA/PIK3CD/MCL1/DIABLO/CTSF/BAK1	23
KEGG	hsa04218	Cellular senescence	26/1160	156/8135	0.2223	0.5406	0.4768	ITPR1/LIN37/MAPK11/SLC25A5/SQSTM1/TGFB2/TGFB1/HIPK1/LIN9/RASSF5/CCND1/PPID/RAF1/NFATC4/SIRT1/RELA/SLC25A6/HLA-B/PIK3CD/CALML4/CDKN2B/PPP3CB/MTOR/HLA-A/IGFBP3/NFATC3	26
KEGG	hsa04614	Renin-angiotensin system	5/1160	23/8135	0.2226	0.5406	0.4768	MME/CTSG/ACE/AGTR1/ENPEP	5
KEGG	hsa05017	Spinocerebellar ataxia	24/1160	143/8135	0.2229	0.5406	0.4768	PSMD14/PSMD12/ITPR1/SLC25A5/PRKCB/PSMD7/PSMB5/FGF14/ERN1/NFYA/GRIA3/KCND3/ULK2/MAP3K5/SLC25A6/PLCB2/ATXN2L/PLCB1/PIK3CD/PSMB7/PSMD1/PSMD9/MTOR/ATXN10	24
KEGG	hsa04012	ErbB signaling pathway	15/1160	85/8135	0.224	0.5406	0.4768	ARAF/NRG4/CAMK2G/PRKCB/JUN/CRKL/RAF1/EGFR/EGF/PAK4/CBL/PIK3CD/PAK3/SOS2/MTOR	15
KEGG	hsa05135	Yersinia infection	23/1160	137/8135	0.2285	0.5437	0.4795	ITGA4/NFKBIA/MAPK11/WASF2/TNF/JUN/CRKL/FN1/FOS/ARHGEF7/TRAF6/VAV1/RELA/PIK3CD/IL2/BCAR1/IL1B/PKN2/VAV3/ARPC2/GIT2/ARHGEF12/NFATC3	23
KEGG	hsa04611	Platelet activation	21/1160	124/8135	0.2286	0.5437	0.4795	ITGB3/ADCY3/PLA2G4C/ITPR1/MAPK11/ADCY7/ADCY4/VWF/P2RY12/BTK/NOS3/ADCY6/PLCB2/PLCB1/PIK3CD/SNAP23/LYN/ITGA2/GP1BA/ARHGEF12/COL1A2	21
KEGG	hsa04720	Long-term potentiation	12/1160	67/8135	0.2404	0.5638	0.4973	ARAF/CAMK2G/ITPR1/EP300/PRKCB/CREBBP/RAF1/RAPGEF3/PLCB2/PLCB1/CALML4/PPP3CB	12
KEGG	hsa05221	Acute myeloid leukemia	12/1160	67/8135	0.2404	0.5638	0.4973	ARAF/TCF7L1/CCND1/RAF1/CEBPE/JUP/PML/RELA/PIK3CD/RUNX1T1/SOS2/MTOR	12
KEGG	hsa04144	Endocytosis	40/1160	251/8135	0.2447	0.5683	0.5012	AMPH/ARF1/PARD3/ASAP2/RAB11FIP4/CAV2/ARFGEF2/PARD6G/RAB11FIP1/RAB11FIP5/PSD3/ITCH/ASAP3/VPS37A/IGF1R/CXCR1/CHMP6/EHD2/DAB2/CHMP1B/TRAF6/EGFR/AP2A2/PML/VPS37B/HLA-B/PDGFRA/CBL/DNM1/CAPZA1/ARFGAP2/PARD6A/VPS26B/ARPC2/CAV1/ACAP2/GIT2/RAB8A/HLA-A/PARD6B	40
KEGG	hsa04728	Dopaminergic synapse	22/1160	132/8135	0.2458	0.5683	0.5012	SLC18A1/CAMK2G/ITPR1/PPP2R3C/MAPK11/PRKCB/PPP2CA/CREB1/MAOA/GNG11/FOS/PPP2R5E/GRIA3/PLCB2/GNB3/PLCB1/CREB3L1/CALML4/PPP3CB/GNG12/GNGT2/GNG10	22
KEGG	hsa05162	Measles	23/1160	139/8135	0.2509	0.5762	0.5082	TNFAIP3/FADD/NFKBIB/NFKBIA/EIF2AK4/JUN/EIF2S1/FCGR2B/CCND1/FOS/TRAF6/BCL2L1/IFIH1/JAK1/RELA/MSN/PIK3CD/RCHY1/IL12A/IL2/IL1B/TLR9/BAK1	23
KEGG	hsa00565	Ether lipid metabolism	9/1160	49/8135	0.258	0.5884	0.5189	PLD4/PLA2G4C/PLA2G5/LPCAT4/TMEM189/GDPD1/PLA2G2A/ENPP2/LPCAT1	9
KEGG	hsa04724	Glutamatergic synapse	19/1160	114/8135	0.266	0.6025	0.5313	ADCY3/PLA2G4C/ITPR1/PRKCB/ADCY7/SLC1A3/ADCY4/GNG11/GRIA3/ADCY6/PLCB2/GNB3/SLC1A1/PLCB1/PPP3CB/GNG12/GNGT2/GNG10/SHANK3	19
KEGG	hsa04710	Circadian rhythm	6/1160	31/8135	0.2751	0.6126	0.5403	BHLHE41/BHLHE40/CREB1/PRKAG2/PER1/CUL1	6
KEGG	hsa04914	Progesterone-mediated oocyte maturation	17/1160	102/8135	0.281	0.6126	0.5403	ADCY3/ARAF/MAPK11/ADCY7/ADCY4/HSP90AA1/RAF1/IGF1R/ADCY6/IGF1/STK10/PIK3CD/ANAPC10/CPEB1/PLK1/HSP90AB1/CPEB2	17
KEGG	hsa04972	Pancreatic secretion	17/1160	102/8135	0.281	0.6126	0.5403	ADCY3/ITPR1/PRKCB/ADCY7/SCT/ATP1B2/ADCY4/PLA2G5/ADCY6/PLCB2/PLCB1/KCNMA1/PLA2G2A/RYR2/CPA2/RAB8A/PRSS2	17
KEGG	hsa04971	Gastric acid secretion	13/1160	76/8135	0.2827	0.6126	0.5403	ADCY3/CAMK2G/ITPR1/PRKCB/ADCY7/KCNJ15/ATP1B2/ADCY4/ADCY6/KCNK10/PLCB2/PLCB1/CALML4	13
KEGG	hsa05212	Pancreatic cancer	13/1160	76/8135	0.2827	0.6126	0.5403	ARAF/TGFB2/TGFB1/CCND1/RAF1/EGFR/BCL2L1/JAK1/RELA/EGF/PIK3CD/MTOR/BAK1	13
KEGG	hsa05220	Chronic myeloid leukemia	13/1160	76/8135	0.2827	0.6126	0.5403	ARAF/NFKBIA/TGFB2/CRKL/TGFB1/CCND1/RAF1/BCL2L1/RELA/CBL/PIK3CD/SOS2/BAK1	13
KEGG	hsa04962	Vasopressin-regulated water reabsorption	8/1160	44/8135	0.2856	0.6126	0.5403	ADCY3/DYNC1I1/CREB1/ADCY6/CREB3L1/STX4/DYNLL2/DCTN4	8
KEGG	hsa05161	Hepatitis B	26/1160	162/8135	0.2868	0.6126	0.5403	ARAF/FADD/EP300/NFKBIA/MAPK11/PRKCB/TNF/JUN/TGFB2/TGFB1/CREB1/CREBBP/RAF1/FOS/NFATC4/TRAF6/IFIH1/JAK1/MAP3K1/RELA/YWHAZ/MMP9/PIK3CD/CREB3L1/SOS2/NFATC3	26
KEGG	hsa04066	HIF-1 signaling pathway	18/1160	109/8135	0.287	0.6126	0.5403	MKNK2/CAMK2G/EP300/PRKCB/FLT1/LDHC/CREBBP/IGF1R/EGFR/NOS3/IGF1/RELA/EGF/PIK3CD/TEK/ANGPT2/MTOR/PFKP	18
KEGG	hsa05150	Staphylococcus aureus infection	16/1160	96/8135	0.2891	0.6132	0.5408	C1QB/C1QA/C1QC/HLA-DPB1/CFH/C2/SELP/CFB/FCGR2B/FCGR3B/CAMP/ITGAL/C1R/C1S/CFI/DEFB1	16
KEGG	hsa04913	Ovarian steroidogenesis	9/1160	51/8135	0.2985	0.6292	0.5549	ADCY3/PLA2G4C/CYP11A1/ADCY7/ADCY4/IGF1R/ADCY6/IGF1/HSD17B1	9
KEGG	hsa03022	Basal transcription factors	8/1160	45/8135	0.3077	0.6434	0.5674	GTF2I/TAF4/TAF10/GTF2H3/GTF2IRD1/TAF3/GTF2E1/TAF1	8
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1160	26/8135	0.3091	0.6434	0.5674	PIGH/PIGX/PIGA/PIGY/PIGL	5
KEGG	hsa04721	Synaptic vesicle cycle	13/1160	78/8135	0.3162	0.6524	0.5754	SLC18A1/STX2/ATP6V1E1/SLC1A3/STXBP1/ATP6V0A2/ATP6V1G3/AP2A2/SLC1A1/DNM1/SLC32A1/UNC13B/SLC6A1	13
KEGG	hsa05321	Inflammatory bowel disease	11/1160	65/8135	0.3185	0.6524	0.5754	MAF/HLA-DPB1/TNF/JUN/TGFB2/TGFB1/IL23R/RELA/IL12A/IL2/IL1B	11
KEGG	hsa05170	Human immunodeficiency virus 1 infection	33/1160	212/8135	0.3193	0.6524	0.5754	ITPR1/FADD/NFKBIA/MAPK11/PRKCB/TNF/JUN/CRKL/PDIA3/SAMHD1/RAF1/GNG11/FOS/NFATC4/TRAF6/BCL2L1/RELA/GNB3/HLA-B/PAK4/PIK3CD/CALML4/PPP3CB/PAK3/GNG12/MTOR/BAK1/GNGT2/AP1S3/GNG10/HLA-A/NFATC3/CUL1	33
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1160	14/8135	0.3217	0.6532	0.576	CHST1/B4GALT2/B4GALT4	3
KEGG	hsa05218	Melanoma	12/1160	72/8135	0.3264	0.6584	0.5807	ARAF/CCND1/RAF1/IGF1R/FGF18/EGFR/IGF1/EGF/PDGFRA/PIK3CD/PDGFRB/BAK1	12
KEGG	hsa04330	Notch signaling pathway	10/1160	59/8135	0.3291	0.6584	0.5807	EP300/HEYL/HES1/JAG2/CREBBP/MFNG/NOTCH1/DTX3L/NOTCH2/NOTCH3	10
KEGG	hsa03050	Proteasome	8/1160	46/8135	0.3302	0.6584	0.5807	PSMD14/PSMD12/PSMD7/PSMB5/PSMB7/PSMD1/PSMD9/PSME1	8
KEGG	hsa00260	Glycine, serine and threonine metabolism	7/1160	40/8135	0.3419	0.6707	0.5915	ALAS2/GNMT/MAOA/AOC3/GCAT/ALAS1/ALDH7A1	7
KEGG	hsa04024	cAMP signaling pathway	34/1160	221/8135	0.3424	0.6707	0.5915	ADCY3/MYL9/SUCNR1/CAMK2G/EP300/BDNF/NFKBIA/ADCY7/JUN/GHRL/ATP1B2/ADCY4/CREB1/CREBBP/RAF1/PDE4B/RAPGEF3/FOS/EDN3/GRIA3/VAV1/ADCY6/RELA/PIK3CD/FXYD1/CREB3L1/SOX9/CALML4/GLI3/OXTR/VAV3/RYR2/ADCYAP1/RAPGEF4	34
KEGG	hsa04725	Cholinergic synapse	18/1160	113/8135	0.3437	0.6707	0.5915	ADCY3/CAMK2G/ITPR1/PRKCB/ADCY7/ADCY4/CREB1/GNG11/FOS/ADCY6/PLCB2/GNB3/PLCB1/PIK3CD/CREB3L1/GNG12/GNGT2/GNG10	18
KEGG	hsa01524	Platinum drug resistance	12/1160	73/8135	0.3444	0.6707	0.5915	PMAIP1/MSH6/PDPK1/FADD/ATP7B/GSTT2/GSTT1/BCL2L1/MAP3K5/PIK3CD/GSTM5/BAK1	12
KEGG	hsa00514	Other types of O-glycan biosynthesis	8/1160	47/8135	0.3529	0.6818	0.6013	B4GALT2/GALNT3/MFNG/GALNT14/GALNT5/GALNT6/ST6GAL1/C1GALT1C1	8
KEGG	hsa04922	Glucagon signaling pathway	17/1160	107/8135	0.3542	0.6818	0.6013	CAMK2G/ITPR1/EP300/CPT1C/CREB1/LDHC/CREBBP/SIRT1/PLCB2/PLCB1/CREB3L1/PRKAG2/CALML4/PPP3CB/PYGB/PHKA1/PFKP	17
KEGG	hsa05169	Epstein-Barr virus infection	31/1160	202/8135	0.3573	0.6837	0.603	PSMD14/PSMD12/HLA-DPB1/TNFAIP3/FADD/NFKBIB/NFKB2/NFKBIA/MAPK11/TNF/JUN/NFKBIE/PSMD7/PDIA3/HES1/CCND1/MAP3K14/BTK/USP7/TRAF6/JAK1/RELA/HLA-B/PIK3CD/ITGAL/PSMD1/SKP2/LYN/BAK1/SIN3A/HLA-A	31
KEGG	hsa04630	JAK-STAT signaling pathway	25/1160	162/8135	0.3666	0.6976	0.6152	SOCS7/EP300/CCND1/CREBBP/RAF1/EGFR/BCL2L1/IL23R/JAK1/EGF/PDGFRA/PIK3CD/IL13RA2/OSMR/IL12A/IL2/LIFR/MCL1/PDGFRB/AOX1/IL17D/SOS2/IL10RA/MTOR/GHR	25
KEGG	hsa04931	Insulin resistance	17/1160	108/8135	0.3693	0.6988	0.6163	PDPK1/NFKBIA/MLXIP/PRKCB/TNF/CREB1/NOS3/RELA/PTPRF/IRS2/PIK3CD/CREB3L1/PRKAG2/PYGB/GFPT2/MTOR/PPP1R3C	17
KEGG	hsa04621	NOD-like receptor signaling pathway	28/1160	184/8135	0.3853	0.7248	0.6393	TRIP6/GABARAPL2/MAP1LC3A/ITPR1/TNFAIP3/FADD/NFKBIB/CASP4/NFKBIA/MAPK11/TNF/JUN/IFI16/HSP90AA1/CAMP/TRAF6/BCL2L1/JAK1/P2RX7/RELA/PLCB2/PLCB1/IL1B/CXCL1/NLRP1/PKN2/HSP90AB1/NLRP7	28
KEGG	hsa04727	GABAergic synapse	14/1160	89/8135	0.3898	0.7281	0.6422	ADCY3/GABARAPL2/PRKCB/ADCY7/ADCY4/GNG11/ADCY6/GNB3/SLC32A1/GNG12/GNGT2/GNG10/SLC6A1/ABAT	14
KEGG	hsa00380	Tryptophan metabolism	7/1160	42/8135	0.3914	0.7281	0.6422	MAOA/DHTKD1/ACAT2/INMT/AADAT/AOX1/ALDH7A1	7
KEGG	hsa04920	Adipocytokine signaling pathway	11/1160	69/8135	0.3948	0.7299	0.6437	NFKBIB/NFKBIA/CPT1C/TNF/NFKBIE/RXRB/RELA/ADIPOR2/IRS2/PRKAG2/MTOR	11
KEGG	hsa04392	Hippo signaling pathway - multiple species	5/1160	29/8135	0.3993	0.7299	0.6437	RASSF1/WWTR1/TEAD4/YAP1/RASSF2	5
KEGG	hsa00360	Phenylalanine metabolism	3/1160	16/8135	0.4046	0.7299	0.6437	MAOA/AOC3/HPD	3
KEGG	hsa00430	Taurine and hypotaurine metabolism	3/1160	16/8135	0.4046	0.7299	0.6437	CDO1/GGT5/FMO3	3
KEGG	hsa00350	Tyrosine metabolism	6/1160	36/8135	0.409	0.7299	0.6437	MAOA/AOC3/AOX1/PNMT/HPD/ADH1C	6
KEGG	hsa03030	DNA replication	6/1160	36/8135	0.409	0.7299	0.6437	PRIM2/RFC1/POLE3/POLE/RNASEH1/MCM5	6
KEGG	hsa04070	Phosphatidylinositol signaling system	15/1160	97/8135	0.4099	0.7299	0.6437	INPP5D/ITPR1/PRKCB/PLCB2/PLCB1/MTMR14/DGKD/PIK3CD/MTM1/CALML4/PLCD4/DGKZ/INPP5F/MTMR7/MTMR4	15
KEGG	hsa00310	Lysine degradation	10/1160	63/8135	0.4099	0.7299	0.6437	PLOD2/PRDM6/DHTKD1/ACAT2/SETD1B/NSD1/AADAT/EZH1/ALDH7A1/SETD2	10
KEGG	hsa03430	Mismatch repair	4/1160	23/8135	0.4198	0.7427	0.655	MSH6/RFC1/EXO1/MLH3	4
KEGG	hsa05110	Vibrio cholerae infection	8/1160	50/8135	0.4219	0.7427	0.655	ADCY3/SEC61B/ARF1/ATP6V1E1/ATP6V0A2/ATP6V1G3/KDELR3/TJP1	8
KEGG	hsa05032	Morphine addiction	14/1160	91/8135	0.4238	0.7427	0.655	ADCY3/PRKCB/ADCY7/ADCY4/PDE2A/PDE4B/GNG11/ADCY6/GNB3/SLC32A1/PDE1A/GNG12/GNGT2/GNG10	14
KEGG	hsa01523	Antifolate resistance	5/1160	30/8135	0.4293	0.7467	0.6586	TNF/ABCG2/RELA/IL1B/MTHFR	5
KEGG	hsa05145	Toxoplasmosis	17/1160	112/8135	0.4306	0.7467	0.6586	PDPK1/HLA-DPB1/NFKBIB/NFKBIA/MAPK11/TNF/TGFB2/LAMC1/TGFB1/LAMC2/TRAF6/BCL2L1/JAK1/RELA/IL12A/LAMB1/IL10RA	17
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	6/1160	37/8135	0.4359	0.7482	0.6599	PDPK1/PRKCB/ATP1B2/HSD11B2/IGF1/PIK3CD	6
KEGG	hsa05216	Thyroid cancer	6/1160	37/8135	0.4359	0.7482	0.6599	PPARG/TCF7L1/RXRB/CCND1/TFG/BAK1	6
KEGG	hsa04932	Non-alcoholic fatty liver disease	23/1160	155/8135	0.4528	0.7693	0.6785	NDUFA10/PPARG/MAPK11/MLXIP/TNF/JUN/TGFB1/NDUFA4L2/ITCH/EIF2S1/ERN1/FOS/DDIT3/MAP3K5/RELA/ADIPOR2/COX7A1/IRS2/PIK3CD/PRKAG2/IL1B/COX8C/NDUFB2	23
KEGG	hsa04137	Mitophagy - animal	11/1160	72/8135	0.4528	0.7693	0.6785	GABARAPL2/MAP1LC3A/SQSTM1/JUN/PINK1/UBA52/BCL2L1/RELA/FUNDC1/RAB7B/UBC	11
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1160	100/8135	0.4591	0.776	0.6844	CXCL5/CSF1/TNF/CX3CL1/CXCR1/CCL13/CXCL12/CXCL6/IL2/TNFRSF14/CCL21/CXCL1/CCL8/IL10RA/CCL18	15
KEGG	hsa05330	Allograft rejection	6/1160	38/8135	0.4626	0.7781	0.6862	HLA-DPB1/TNF/HLA-B/IL12A/IL2/HLA-A	6
KEGG	hsa04370	VEGF signaling pathway	9/1160	59/8135	0.4694	0.7819	0.6896	PLA2G4C/MAPK11/PRKCB/RAF1/NOS3/HSPB1/PIK3CD/PPP3CB/KDR	9
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	31/1160	212/8135	0.4696	0.7819	0.6896	ADCY3/PRKCB/HSP90B1/ADCY7/JUN/ADCY4/RXRB/CREB1/CCND1/HSP90AA1/RAF1/FGF18/FOS/GSTT2/KPNA1/EGFR/GSTT1/ADCY6/RELA/EGF/KPNA3/PIK3CD/GSTM5/KLF4/CREB3L1/KLF5/NOTCH2/SOS2/HSP90AB1/MTOR/KPNA4	31
KEGG	hsa04115	p53 signaling pathway	11/1160	73/8135	0.472	0.782	0.6897	PMAIP1/PPM1D/CCND1/MDM4/SESN2/BCL2L1/IGF1/RPRM/RCHY1/SESN3/IGFBP3	11
KEGG	hsa05160	Hepatitis C	23/1160	157/8135	0.4791	0.7861	0.6933	ARAF/CLDN5/FADD/NFKBIA/EIF2AK4/TNF/PPP2CA/EIF2S1/CCND1/RAF1/CLDN11/TRAF6/EGFR/JAK1/RELA/YWHAZ/EGF/PIK3CD/IFIT1/SOS2/BAK1/RSAD2/CLDN10	23
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1160	11/8135	0.4792	0.7861	0.6933	HPD/NQO1	2
KEGG	hsa04136	Autophagy - other	5/1160	32/8135	0.4881	0.7929	0.6993	GABARAPL2/PPP2CA/ULK2/ATG4B/MTOR	5
KEGG	hsa04215	Apoptosis - multiple species	5/1160	32/8135	0.4881	0.7929	0.6993	PMAIP1/FADD/BCL2L1/DIABLO/BAK1	5
KEGG	hsa05416	Viral myocarditis	9/1160	60/8135	0.4906	0.793	0.6994	HLA-DPB1/CCND1/SGCD/HLA-B/ITGAL/SGCB/CAV1/DMD/HLA-A	9
KEGG	hsa04114	Oocyte meiosis	19/1160	131/8135	0.5064	0.8145	0.7183	ADCY3/CAMK2G/ITPR1/MAPK11/ADCY7/PPP2CA/ADCY4/IGF1R/PPP2R5E/ADCY6/IGF1/YWHAZ/ANAPC10/CPEB1/PLK1/CALML4/PPP3CB/CUL1/CPEB2	19
KEGG	hsa00140	Steroid hormone biosynthesis	9/1160	61/8135	0.5116	0.8145	0.7183	CYP11A1/CYP21A2/HSD11B2/HSD11B1/HSD17B1/AKR1C2/AKR1D1/CYP3A5/HSD17B3	9
KEGG	hsa00590	Arachidonic acid metabolism	9/1160	61/8135	0.5116	0.8145	0.7183	PLA2G4C/CYP4F2/CYP4F3/GGT5/PLA2G5/CBR3/GPX8/PLA2G2A/HPGDS	9
KEGG	hsa04973	Carbohydrate digestion and absorption	7/1160	47/8135	0.5136	0.8145	0.7183	SLC2A5/PRKCB/ATP1B2/PLCB2/PLCB1/PIK3CD/SLC37A4	7
KEGG	hsa04110	Cell cycle	18/1160	126/8135	0.5359	0.8437	0.7441	EP300/TGFB2/TGFB1/CDKN1C/CCND1/CDKN2C/CREBBP/YWHAZ/BUB1B/CDC45/DBF4/ANAPC10/PLK1/CDKN2B/SKP2/TTK/CUL1/MCM5	18
KEGG	hsa04071	Sphingolipid signaling pathway	17/1160	119/8135	0.5371	0.8437	0.7441	PDPK1/PPP2R3C/MAPK11/PRKCB/TNF/PPP2CA/FCER1A/RAF1/BDKRB2/PPP2R5E/NOS3/MAP3K5/RELA/PLCB2/PLCB1/PIK3CD/ADORA3	17
KEGG	hsa04723	Retrograde endocannabinoid signaling	21/1160	148/8135	0.5463	0.8523	0.7516	ADCY3/NDUFA10/ITPR1/MAPK11/DAGLB/PRKCB/ADCY7/ADCY4/NDUFA4L2/MGLL/GNG11/GRIA3/ADCY6/PLCB2/GNB3/PLCB1/SLC32A1/GNG12/NDUFB2/GNGT2/GNG10	21
KEGG	hsa04917	Prolactin signaling pathway	10/1160	70/8135	0.5498	0.8523	0.7516	SOCS7/MAPK11/IRF1/CCND1/RAF1/FOS/RELA/TNFRSF11A/PIK3CD/SOS2	10
KEGG	hsa04966	Collecting duct acid secretion	4/1160	27/8135	0.5503	0.8523	0.7516	SLC4A1/ATP6V1E1/ATP6V0A2/ATP6V1G3	4
KEGG	hsa04672	Intestinal immune network for IgA production	7/1160	49/8135	0.5602	0.8635	0.7616	HLA-DPB1/ITGA4/TGFB1/MAP3K14/CXCL12/PIGR/IL2	7
KEGG	hsa05332	Graft-versus-host disease	6/1160	42/8135	0.5653	0.8635	0.7616	HLA-DPB1/TNF/HLA-B/IL2/IL1B/HLA-A	6
KEGG	hsa04612	Antigen processing and presentation	11/1160	78/8135	0.5655	0.8635	0.7616	HLA-DPB1/TNF/PDIA3/CREB1/HSP90AA1/NFYA/HLA-B/HSP90AB1/PSME1/HSPA5/HLA-A	11
KEGG	hsa05016	Huntington disease	43/1160	306/8135	0.5679	0.8635	0.7616	TFAM/PSMD14/PSMD12/NDUFA10/ITPR1/PPARG/EP300/BDNF/SLC25A5/TAF4/SLC1A3/PSMD7/PSMB5/ACTR10/CREB1/NDUFA4L2/ERN1/CREBBP/GRIA3/AP2A2/ULK2/MAP3K5/SLC25A6/POLR2G/PLCB2/PLCB1/COX7A1/PSMB7/CREB3L1/GPX8/PSMD1/PSMD9/REST/COX8C/DNALI1/NDUFB2/MTOR/DNAH5/DNAH17/POLR2D/DCTN4/SIN3A/KLC1	43
KEGG	hsa00650	Butanoate metabolism	4/1160	28/8135	0.5804	0.8786	0.7749	ACAT2/HMGCS1/ABAT/HMGCL	4
KEGG	hsa04726	Serotonergic synapse	16/1160	115/8135	0.5837	0.8795	0.7757	SLC18A1/PLA2G4C/ARAF/ITPR1/PRKCB/MAOA/RAF1/GNG11/RAPGEF3/PLCB2/GNB3/PLCB1/GNG12/DUSP1/GNGT2/GNG10	16
KEGG	hsa00860	Porphyrin metabolism	6/1160	43/8135	0.5895	0.8813	0.7773	ALAS2/UROD/FXN/CP/ALAS1/HEPH	6
KEGG	hsa04910	Insulin signaling pathway	19/1160	137/8135	0.5902	0.8813	0.7773	MKNK2/ARAF/PDPK1/PRKAR2A/CRKL/RAF1/PTPRF/CBL/IRS2/PIK3CD/PRKAG2/CALML4/SORBS1/PYGB/SOS2/MTOR/PPP1R3C/PRKAR2B/PHKA1	19
KEGG	hsa00512	Mucin type O-glycan biosynthesis	5/1160	36/8135	0.598	0.8859	0.7813	GALNT3/GALNT14/GALNT5/GALNT6/C1GALT1C1	5
KEGG	hsa04145	Phagosome	21/1160	152/8135	0.5986	0.8859	0.7813	ITGB3/ITGB5/SEC61B/HLA-DPB1/ATP6V1E1/DYNC1I1/FCGR2B/ATP6V0A2/FCGR3B/ATP6V1G3/MSR1/MRC2/THBS4/HLA-B/THBS3/C1R/RAB7B/COLEC12/ITGA2/CORO1A/HLA-A	21
KEGG	hsa00330	Arginine and proline metabolism	7/1160	51/8135	0.6047	0.8889	0.784	ARG2/ARG1/AMD1/MAOA/PYCR1/NOS3/ALDH7A1	7
KEGG	hsa00562	Inositol phosphate metabolism	10/1160	73/8135	0.606	0.8889	0.784	INPP5D/PLCB2/PLCB1/MTMR14/PIK3CD/MTM1/PLCD4/INPP5F/MTMR7/MTMR4	10
KEGG	hsa05203	Viral carcinogenesis	28/1160	204/8135	0.6184	0.9032	0.7966	PMAIP1/POLB/EP300/NFKB2/NFKBIA/JUN/DLG1/CREB1/GTF2H3/CCND1/CREBBP/REL/USP7/JAK1/UBR4/RELA/YWHAZ/HLA-B/HNRNPK/PIK3CD/ACTN1/CREB3L1/GTF2E1/CDKN2B/SKP2/LYN/BAK1/HLA-A	28
KEGG	hsa00900	Terpenoid backbone biosynthesis	3/1160	22/8135	0.6259	0.9101	0.8027	ACAT2/IDI2/HMGCS1	3
KEGG	hsa02010	ABC transporters	6/1160	45/8135	0.6356	0.9202	0.8116	ABCB6/ABCG2/ABCA4/ABCB7/ABCA9/DEFB1	6
KEGG	hsa00730	Thiamine metabolism	2/1160	15/8135	0.6526	0.9407	0.8296	ALPL/TPK1	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	3/1160	23/8135	0.6568	0.9427	0.8314	ATP1B2/CA4/AQP1	3
KEGG	hsa05310	Asthma	4/1160	31/8135	0.6636	0.9475	0.8357	HLA-DPB1/TNF/FCER1A/RNASE3	4
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1160	223/8135	0.6658	0.9475	0.8357	NDUFA10/ARAF/PDPK1/KEAP1/NFKBIA/MAPK11/SLC25A5/JUN/NDUFA4L2/MAP3K14/RAF1/FOS/GSTT2/EGFR/GSTT1/MAP3K5/RELA/SLC25A6/EGF/COX7A1/AKR1C2/PIK3CD/SLC26A6/GSTM5/NOX4/COX8C/CYP2F1/SOS2/NDUFB2/NQO1	30
KEGG	hsa00620	Pyruvate metabolism	6/1160	47/8135	0.6785	0.9615	0.848	ME1/LDHC/ACAT2/ME3/ALDH7A1/ADH1C	6
KEGG	hsa05010	Alzheimer disease	52/1160	384/8135	0.6824	0.9628	0.8492	PSMD14/PSMD12/NDUFA10/ARAF/MME/ITPR1/FADD/APC/CSF1/SLC25A5/SNCA/TNF/LPL/WNT5B/PSMD7/PSMB5/NDUFA4L2/EIF2S1/ERN1/PPID/RAF1/DDIT3/ULK2/MAP3K5/RELA/SLC25A6/PLCB2/CSNK1A1/PLCB1/COX7A1/IRS2/WNT9A/FZD10/PIK3CD/IDE/PSMB7/CALML4/IL1B/PSMD1/PPP3CB/PSMD9/FZD5/CDK5R1/NOX4/WNT5A/COX8C/NDUFB2/MTOR/FZD4/SLC39A2/LRP5/KLC1	52
KEGG	hsa04977	Vitamin digestion and absorption	3/1160	24/8135	0.6858	0.9636	0.8498	LMBRD1/SLC23A1/MMACHC	3
KEGG	hsa04970	Salivary secretion	12/1160	93/8135	0.6912	0.9671	0.8529	ADCY3/ITPR1/PRKCB/ADCY7/ATP1B2/ADCY4/CAMP/ADCY6/PLCB2/PLCB1/KCNMA1/CALML4	12
KEGG	hsa00280	Valine, leucine and isoleucine degradation	6/1160	48/8135	0.6987	0.9735	0.8586	ACAT2/AOX1/HMGCS1/ALDH7A1/ABAT/HMGCL	6
KEGG	hsa04923	Regulation of lipolysis in adipocytes	7/1160	56/8135	0.7045	0.9775	0.8621	ADCY3/ADCY7/ADCY4/MGLL/ADCY6/IRS2/PIK3CD	7
KEGG	hsa04929	GnRH secretion	8/1160	64/8135	0.7103	0.9811	0.8652	ITPR1/PRKCB/KCNN3/RAF1/SPP1/PLCB2/PLCB1/PIK3CD	8
KEGG	hsa00592	alpha-Linolenic acid metabolism	3/1160	25/8135	0.713	0.9811	0.8652	PLA2G4C/PLA2G5/PLA2G2A	3
KEGG	hsa00982	Drug metabolism - cytochrome P450	9/1160	72/8135	0.7162	0.9814	0.8655	MAOA/GSTT2/GSTT1/FMO3/GSTM5/AOX1/HPGDS/CYP3A5/ADH1C	9
KEGG	hsa00450	Selenocompound metabolism	2/1160	17/8135	0.7204	0.9831	0.8671	SEPHS2/INMT	2
KEGG	hsa05012	Parkinson disease	35/1160	266/8135	0.7254	0.9859	0.8695	SLC18A1/PSMD14/PSMD12/NDUFA10/CAMK2G/ITPR1/KEAP1/SLC25A5/SNCA/PSMD7/PINK1/PSMB5/NDUFA4L2/UBA52/EIF2S1/ERN1/MAOA/DDIT3/BCL2L1/UCHL1/MAP3K5/SLC25A6/COX7A1/PSMB7/CALML4/PSMD1/PSMD9/UBC/COX8C/UBE2G2/DUSP1/NDUFB2/HSPA5/SLC39A2/KLC1	35
KEGG	hsa04979	Cholesterol metabolism	6/1160	50/8135	0.7365	0.9915	0.8744	MYLIP/LIPA/LPL/APOC1/ANGPTL4/PLTP	6
KEGG	hsa00790	Folate biosynthesis	3/1160	26/8135	0.7383	0.9915	0.8744	ALPL/GCH1/PTS	3
KEGG	hsa04620	Toll-like receptor signaling pathway	13/1160	104/8135	0.7384	0.9915	0.8744	FADD/NFKBIA/MAPK11/TNF/JUN/FOS/SPP1/TRAF6/RELA/PIK3CD/IL12A/IL1B/TLR9	13
KEGG	hsa00061	Fatty acid biosynthesis	2/1160	18/8135	0.7499	0.9988	0.8809	OLAH/OXSM	2
KEGG	hsa00511	Other glycan degradation	2/1160	18/8135	0.7499	0.9988	0.8809	AGA/ENGASE	2
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1160	27/8135	0.7618	1	0.8819	B4GALT2/B3GALNT1/B4GALT4	3
KEGG	hsa04978	Mineral absorption	7/1160	60/8135	0.7712	1	0.8819	ATP7B/ATP1B2/MT2A/SLC26A6/STEAP1/STEAP2/HEPH	7
KEGG	hsa00830	Retinol metabolism	8/1160	68/8135	0.7726	1	0.8819	DHRS9/CYP26B1/CYP27C1/AOX1/ALDH1A3/ALDH1A2/CYP3A5/ADH1C	8
KEGG	hsa00531	Glycosaminoglycan degradation	2/1160	19/8135	0.7767	1	0.8819	IDS/HYAL1	2
KEGG	hsa05020	Prion disease	35/1160	273/8135	0.7799	1	0.8819	C1QB/C1QA/PSMD14/C1QC/PSMD12/NDUFA10/ITPR1/MAPK11/SLC25A5/CAV2/TNF/LAMC1/PSMD7/PSMB5/CREB1/NDUFA4L2/EIF2S1/DDIT3/SLC25A6/COX7A1/PIK3CD/PSMB7/CREB3L1/NOTCH1/IL1B/PSMD1/PPP3CB/PSMD9/COX8C/RYR2/NDUFB2/CAV1/HSPA5/NCAM2/KLC1	35
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	16/1160	131/8135	0.7854	1	0.8819	ARAF/PRKCB/TNF/CD244/FCGR3B/RAF1/VAV1/CD48/HLA-B/PIK3CD/ITGAL/HCST/PPP3CB/VAV3/SOS2/HLA-A	16
KEGG	hsa00920	Sulfur metabolism	1/1160	10/8135	0.7855	1	0.8819	SELENBP1	1
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	4/1160	37/8135	0.7939	1	0.8819	ASS1/CPS1/GFPT2/ABAT	4
KEGG	hsa05230	Central carbon metabolism in cancer	8/1160	70/8135	0.7999	1	0.8819	LDHC/RAF1/EGFR/PDGFRA/PIK3CD/PDGFRB/MTOR/PFKP	8
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1160	78/8135	0.8005	1	0.8819	GSTT2/GSTT1/HSD11B1/CBR3/GSTM5/CYP2F1/HPGDS/CYP3A5/ADH1C	9
KEGG	hsa00670	One carbon pool by folate	2/1160	20/8135	0.8009	1	0.8819	ALDH1L2/MTHFR	2
KEGG	hsa00591	Linoleic acid metabolism	3/1160	29/8135	0.8036	1	0.8819	PLA2G4C/PLA2G5/PLA2G2A	3
KEGG	hsa04744	Phototransduction	3/1160	29/8135	0.8036	1	0.8819	GUCY2D/CALML4/PDE6G	3
KEGG	hsa04260	Cardiac muscle contraction	10/1160	87/8135	0.8131	1	0.8819	CACNA2D2/MYL4/ATP1B2/TPM1/CACNB3/ASPH/COX7A1/CACNA2D3/COX8C/RYR2	10
KEGG	hsa05415	Diabetic cardiomyopathy	25/1160	203/8135	0.8159	1	0.8819	NDUFA10/CAMK2G/MAPK11/SLC25A5/PRKCB/TGFB2/TGFB1/NDUFA4L2/ACE/NOS3/RELA/SLC25A6/PLCB2/PLCB1/COX7A1/MMP9/PIK3CD/AGTR1/COX8C/RYR2/NDUFB2/GFPT2/MTOR/PDK4/COL1A2	25
KEGG	hsa04217	Necroptosis	19/1160	159/8135	0.83	1	0.8819	PLA2G4C/CAMK2G/TNFAIP3/FADD/SPATA2/SLC25A5/SQSTM1/TNF/PPID/HSP90AA1/CHMP6/CHMP1B/CYLD/JAK1/SLC25A6/IL1B/IL33/PYGB/HSP90AB1	19
KEGG	hsa04613	Neutrophil extracellular trap formation	23/1160	190/8135	0.8323	1	0.8819	ITGB3/CR1L/CTSG/CASP4/MAPK11/SLC25A5/PRKCB/HAT1/ELANE/SELP/VWF/FCGR3B/RAF1/CAMP/RELA/SLC25A6/PLCB2/PLCB1/PIK3CD/ITGAL/MTOR/GP1BA/CLCN4	23
KEGG	hsa04976	Bile secretion	10/1160	89/8135	0.8345	1	0.8819	ADCY3/ADCY7/SCT/ATP1B2/ADCY4/SLC10A2/ABCG2/ADCY6/AQP1/NR1H4	10
KEGG	hsa00052	Galactose metabolism	3/1160	31/8135	0.8391	1	0.8819	B4GALT2/UGP2/PFKP	3
KEGG	hsa00410	beta-Alanine metabolism	3/1160	31/8135	0.8391	1	0.8819	AOC3/ALDH7A1/ABAT	3
KEGG	hsa00340	Histidine metabolism	2/1160	22/8135	0.8425	1	0.8819	MAOA/ALDH7A1	2
KEGG	hsa00564	Glycerophospholipid metabolism	11/1160	98/8135	0.8443	1	0.8819	PLD4/PLA2G4C/PTDSS1/PLA2G5/LPCAT4/DGKD/LPCAT3/PLA2G2A/DGKZ/PCYT1A/LPCAT1	11
KEGG	hsa00480	Glutathione metabolism	6/1160	58/8135	0.8535	1	0.8819	GGT5/GSTT2/GSTT1/GSTM5/GPX8/HPGDS	6
KEGG	hsa04216	Ferroptosis	4/1160	41/8135	0.8557	1	0.8819	MAP1LC3A/CP/LPCAT3/PCBP2	4
KEGG	hsa04714	Thermogenesis	28/1160	232/8135	0.857	1	0.8819	ADCY3/NDUFA10/ARID1A/ARID1B/PPARG/MAPK11/CPT1C/ADCY7/ADCY4/CREB1/NDUFA4L2/MGLL/SMARCC1/COX16/ADCY6/MAP3K5/COX19/COX7A1/FRS2/CREB3L1/BMP8A/PRKAG2/COX8C/SOS2/NDUFB2/MTOR/NDUFAF3/SLC25A29	28
KEGG	hsa01230	Biosynthesis of amino acids	8/1160	75/8135	0.8572	1	0.8819	ARG2/ARG1/PYCR1/ASS1/CPS1/MAT2A/RPIA/PFKP	8
KEGG	hsa05168	Herpes simplex virus 1 infection	63/1160	495/8135	0.8588	1	0.8819	ITGB3/ZNF589/ZNF791/ZNF34/ZNF19/HLA-DPB1/NXF3/FADD/NFKBIA/EIF2AK4/ZNF302/TNF/ZFP57/PDIA3/ZNF324/ZNF333/ZNF619/ZNF614/ZNF584/EIF2S1/ZNF620/ZNF460/ZNF17/ZNF189/ZNF33B/TRAF6/BCL2L1/IFIH1/JAK1/PML/RELA/ZNF440/RBAK/ZNF169/HLA-B/PIK3CD/ZNF136/IL12A/ZNF334/ZNF81/NXF1/HCFC1/TNFRSF14/ZNF597/ZNF354B/ZNF669/IL1B/ZNF670/ZNF79/ZNF713/ZNF214/TLR9/POU2F2/MTOR/BAK1/ZNF316/ZNF595/ZNF268/HLA-A/ZNF814/EIF2B2/ZNF430/ZNF587	63
KEGG	hsa00515	Mannose type O-glycan biosynthesis	2/1160	23/8135	0.8602	1	0.8819	B4GALT2/FKRP	2
KEGG	hsa03450	Non-homologous end-joining	1/1160	13/8135	0.8649	1	0.8819	XRCC6	1
KEGG	hsa04060	Cytokine-cytokine receptor interaction	36/1160	295/8135	0.8684	1	0.8819	CXCL5/ACVR1/INHBA/CSF1/TNF/TGFB2/IL1R1/TGFB1/CX3CL1/BMP2/CXCR1/CCL13/IL23R/ACVR2A/CXCL12/CXCL6/TNFRSF11A/INHBE/IL13RA2/OSMR/RELT/IL12A/IL2/LIFR/TNFRSF14/BMP8A/IL1B/IL17D/CCL21/IL33/CXCL1/CCL8/IL26/IL10RA/GHR/CCL18	36
KEGG	hsa00051	Fructose and mannose metabolism	3/1160	33/8135	0.8689	1	0.8819	PFKFB2/KHK/PFKP	3
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	7/1160	69/8135	0.8797	1	0.8819	GSTT2/GSTT1/HSD11B1/AKR1C2/GSTM5/HPGDS/CYP3A5	7
KEGG	hsa00071	Fatty acid degradation	4/1160	43/8135	0.8802	1	0.8819	CPT1C/ACAT2/ALDH7A1/ADH1C	4
KEGG	hsa04742	Taste transduction	9/1160	86/8135	0.8818	1	0.8819	ADCY4/ADCY6/TAS2R39/PLCB2/GNB3/PLCB1/TAS2R45/PDE1A/TRPM5	9
KEGG	hsa01240	Biosynthesis of cofactors	17/1160	153/8135	0.8959	1	0.8819	ALAS2/UROD/UGP2/ALPL/OXSM/GCH1/QPRT/PTS/LIAS/NADSYN1/TPK1/PANK1/HPD/MAT2A/ALAS1/NMNAT3/NQO1	17
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1160	15/8135	0.9007	1	0.8819	B3GALNT1	1
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1160	15/8135	0.9007	1	0.8819	B3GALT4	1
KEGG	hsa03460	Fanconi anemia pathway	5/1160	54/8135	0.9007	1	0.8819	HES1/TELO2/FANCL/PALB2/MUS81	5
KEGG	hsa05206	MicroRNAs in cancer	37/1160	310/8135	0.9013	1	0.8819	ITGB3/SPRY2/RASSF1/EP300/APC/PRKCB/TGFB2/CRKL/TNXB/TPM1/CCND1/MIR21/CREBBP/RAF1/SIRT1/MDM4/EGFR/PAK4/PDGFRA/HNRNPK/MMP9/IRS2/TIMP3/PIK3CD/BMF/MCL1/PDGFRB/NOTCH1/NOTCH2/ZFPM2/MIR214/SOS2/MTOR/BAK1/RPS6KA5/TNC/NOTCH3	37
KEGG	hsa04950	Maturity onset diabetes of the young	2/1160	26/8135	0.9028	1	0.8819	HES1/NR5A2	2
KEGG	hsa04930	Type II diabetes mellitus	4/1160	46/8135	0.9102	1	0.8819	TNF/IRS2/PIK3CD/MTOR	4
KEGG	hsa00062	Fatty acid elongation	2/1160	27/8135	0.9141	1	0.8819	ELOVL7/ELOVL5	2
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	2/1160	27/8135	0.9141	1	0.8819	ELOVL7/ELOVL5	2
KEGG	hsa01250	Biosynthesis of nucleotide sugars	3/1160	37/8135	0.9142	1	0.8819	CMAS/UGP2/GFPT2	3
KEGG	hsa03420	Nucleotide excision repair	4/1160	47/8135	0.9186	1	0.8819	RFC1/POLE3/GTF2H3/POLE	4
KEGG	hsa01212	Fatty acid metabolism	5/1160	57/8135	0.9243	1	0.8819	CPT1C/OXSM/ACAT2/ELOVL7/ELOVL5	5
KEGG	hsa05322	Systemic lupus erythematosus	14/1160	136/8135	0.9327	1	0.8819	C1QB/C1QA/C1QC/HLA-DPB1/CTSG/TNF/ELANE/C2/TRIM21/FCGR3B/SNRPB/ACTN1/C1R/C1S	14
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1160	49/8135	0.9333	1	0.8819	CHIT1/CMAS/UGP2/GFPT2	4
KEGG	hsa00030	Pentose phosphate pathway	2/1160	30/8135	0.941	1	0.8819	RPIA/PFKP	2
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/1160	30/8135	0.941	1	0.8819	KL/ALDH7A1	2
KEGG	hsa03440	Homologous recombination	3/1160	41/8135	0.9448	1	0.8819	PALB2/MUS81/BARD1	3
KEGG	hsa00270	Cysteine and methionine metabolism	4/1160	51/8135	0.9455	1	0.8819	AMD1/CDO1/LDHC/MAT2A	4
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	1/1160	19/8135	0.9464	1	0.8819	AADAT	1
KEGG	hsa00561	Glycerolipid metabolism	5/1160	61/8135	0.948	1	0.8819	LPL/MGLL/DGKD/DGKZ/ALDH7A1	5
KEGG	hsa04142	Lysosome	13/1160	132/8135	0.9496	1	0.8819	IDS/CTSG/LIPA/AGA/GNPTAB/ATP6V0A2/LAPTM4B/ACP5/CTSF/SLC17A5/AP1S3/AP4E1/HYAL1	13
KEGG	hsa00100	Steroid biosynthesis	1/1160	20/8135	0.9541	1	0.8819	LIPA	1
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1160	20/8135	0.9541	1	0.8819	CHST3	1
KEGG	hsa00640	Propanoate metabolism	2/1160	32/8135	0.9543	1	0.8819	LDHC/ABAT	2
KEGG	hsa05320	Autoimmune thyroid disease	4/1160	53/8135	0.9557	1	0.8819	HLA-DPB1/HLA-B/IL2/HLA-A	4
KEGG	hsa04975	Fat digestion and absorption	3/1160	43/8135	0.956	1	0.8819	PLA2G5/ACAT2/PLA2G2A	3
KEGG	hsa04623	Cytosolic DNA-sensing pathway	5/1160	63/8135	0.9571	1	0.8819	NFKBIB/NFKBIA/RELA/IL1B/IL33	5
KEGG	hsa00770	Pantothenate and CoA biosynthesis	1/1160	21/8135	0.9606	1	0.8819	PANK1	1
KEGG	hsa00230	Purine metabolism	12/1160	128/8135	0.9635	1	0.8819	ADCY3/GMPR/GUCY2D/ADCY7/ADCY4/PDE2A/PDE4B/ADCY6/AMPD2/PDE1A/PFAS/PDE6G	12
KEGG	hsa00040	Pentose and glucuronate interconversions	2/1160	34/8135	0.9647	1	0.8819	UGP2/KL	2
KEGG	hsa03020	RNA polymerase	2/1160	34/8135	0.9647	1	0.8819	POLR2G/POLR2D	2
KEGG	hsa00500	Starch and sucrose metabolism	2/1160	36/8135	0.9728	1	0.8819	UGP2/PYGB	2
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1160	24/8135	0.9752	1	0.8819	HS3ST2	1
KEGG	hsa05340	Primary immunodeficiency	2/1160	38/8135	0.979	1	0.8819	BTK/PTPRC	2
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	9/1160	109/8135	0.9803	1	0.8819	NXF3/NXT1/UTP14A/RIOK1/EMG1/NXF1/UTP14C/TCOF1/NHP2	9
KEGG	hsa05033	Nicotine addiction	2/1160	40/8135	0.9839	1	0.8819	GRIA3/SLC32A1	2
KEGG	hsa04080	Neuroactive ligand-receptor interaction	37/1160	353/8135	0.987	1	0.8819	EDNRB/CYSLTR2/CTSG/VIPR1/PARD3/GHRL/SCT/LPAR6/TRH/TACR1/ADRA2A/THRB/BDKRB2/PTGER4/EDN3/CALCRL/GRIA3/P2RX7/LPAR4/GLP2R/MCHR1/GPR35/PTH1R/PTGFR/P2RY2/AGTR1/HRH1/APLNR/RXFP2/NR3C1/OXTR/P2RY8/GHR/ADCYAP1/GLRB/PRSS2/ADORA3	37
KEGG	hsa05034	Alcoholism	17/1160	187/8135	0.9881	1	0.8819	SLC18A1/ARAF/FOSB/BDNF/HAT1/CREB1/MAOA/RAF1/GNG11/NTRK2/GNB3/CREB3L1/CALML4/GNG12/SOS2/GNGT2/GNG10	17
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1160	30/8135	0.9902	1	0.8819	ACAT2	1
KEGG	hsa00010	Glycolysis / Gluconeogenesis	4/1160	67/8135	0.9904	1	0.8819	LDHC/ALDH7A1/ADH1C/PFKP	4
KEGG	hsa00600	Sphingolipid metabolism	2/1160	52/8135	0.9968	1	0.8819	SMPD3/CERK	2
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	3/1160	66/8135	0.9973	1	0.8819	CARS2/SARS2/PARS2	3
KEGG	hsa00983	Drug metabolism - other enzymes	4/1160	80/8135	0.9979	1	0.8819	GSTT2/GSTT1/GSTM5/TK1	4
KEGG	hsa00190	Oxidative phosphorylation	8/1160	134/8135	0.9993	1	0.8819	NDUFA10/ATP6V1E1/NDUFA4L2/ATP6V0A2/ATP6V1G3/COX7A1/COX8C/NDUFB2	8
KEGG	hsa01200	Carbon metabolism	6/1160	115/8135	0.9995	1	0.8819	ME1/ACAT2/CPS1/ME3/RPIA/PFKP	6
KEGG	hsa01232	Nucleotide metabolism	3/1160	85/8135	0.9998	1	0.8819	GMPR/AMPD2/TK1	3
KEGG	hsa00240	Pyrimidine metabolism	1/1160	58/8135	0.9999	1	0.8819	TK1	1
KEGG	hsa04146	Peroxisome	2/1160	82/8135	1	1	0.8819	CRAT/HMGCL	2
KEGG	hsa04740	Olfactory transduction	12/1160	440/8135	1	1	0.8819	ADCY3/GUCY2D/CAMK2G/OR2L2/PDE2A/OR51E1/OR2W3/OR2F1/OR10H2/CALML4/PDE1A/OR1A1	12