ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04145	Phagosome	55/1523	152/8135	2.334e-07	7.641e-05	6.261e-05	ATP6V1C2/FCGR2B/ATP6V0A4/PLA2R1/MSR1/NOS1/ITGAM/HLA-DMA/SFTPD/HLA-DRB1/MARCO/ITGA2/FCGR2C/NCF4/ITGB3/FCGR2A/ITGB2/TUBA3C/HLA-B/TUBA4A/HLA-DRA/HLA-G/ATP6V0E1/OLR1/DYNC1LI1/HLA-DMB/FCGR1A/RAB5C/CYBB/CTSS/TUBB3/CYBA/ATP6V1E1/RAB5B/HLA-DRB4/ITGA5/TCIRG1/TLR4/HLA-F/HLA-C/THBS4/DYNC1I1/TUBB2A/TUBA8/TLR2/ATP6V1G3/HLA-DPA1/CANX/MPO/CORO1A/TUBAL3/SEC22B/SEC61A1/CD14/THBS1	55
KEGG	hsa05150	Staphylococcus aureus infection	39/1523	96/8135	4.575e-07	7.641e-05	6.261e-05	C1QB/C1QA/KRT17/KRT10/KRT23/KRT14/DSG1/KRT15/KRT16/FCGR2B/C3AR1/DEFB4A/KRT9/KRT19/KRT31/ITGAM/HLA-DMA/HLA-DRB1/C5AR1/FCGR2C/KRT33A/C2/FCGR2A/ITGB2/KRT34/SELPLG/HLA-DRA/HLA-DMB/KRT25/FCGR1A/KRT27/C1QC/HLA-DRB4/IL10/DEFB1/FPR1/HLA-DPA1/FPR2/KRT35	39
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	36/1523	97/8135	1.463e-05	0.001629	0.001335	PLA2G4F/FCGR2B/PIP5K1A/PRKCE/VAV3/ACTR3B/PLA2G4D/FCGR2A/AMPH/SPHK2/PLA2G4C/ARPC1B/ACTR3C/LIMK2/FCGR1A/MAP2K1/AKT1/ARPC5/PIK3R2/PIP5K1C/WAS/PTPRC/PIK3R3/PRKCA/AKT3/CFL1/RAF1/VAV1/ARPC5L/MYO10/RAC2/VASP/INPPL1/HCK/PIK3R1/ARPC4	36
KEGG	hsa04514	Cell adhesion molecules	48/1523	149/8135	4.904e-05	0.00336	0.002753	CDH1/OCLN/NRCAM/CDH3/NTNG2/CNTN1/CLDN1/IGSF11/VTCN1/CLDN8/CLDN10/ITGAM/HLA-DMA/GLG1/HLA-DRB1/NFASC/CLDN4/CD99/ITGB2/NLGN2/ICAM2/CD4/PDCD1LG2/CD86/SELPLG/NRXN1/HLA-B/HLA-DRA/HLA-G/PTPRF/CDH15/HLA-DMB/CD40/F11R/HLA-DRB4/SDC1/HLA-F/PTPRC/HLA-C/SELE/NRXN3/CD99L2/ICAM3/SDC3/HLA-DPA1/SDC2/LRRC4C/NEO1	48
KEGG	hsa00100	Steroid biosynthesis	12/1523	20/8135	5.029e-05	0.00336	0.002753	DHCR7/TM7SF2/DHCR24/LSS/CYP51A1/SQLE/FDFT1/NSDHL/CYP27B1/HSD17B7/CYP24A1/EBP	12
KEGG	hsa04071	Sphingolipid signaling pathway	40/1523	119/8135	7.161e-05	0.00359	0.002941	PPP2R2C/ADORA3/HRAS/ACER1/PRKCE/DEGS1/FCER1G/DEGS2/SGPP2/FYN/PPP2R3A/MAPK12/SPHK2/GNAI2/ROCK1/GNAI1/SMPD2/MAP2K1/AKT1/GNA12/PIK3R2/FCER1A/KNG1/MAPK13/SPTLC3/PIK3R3/PRKCA/PRKCZ/AKT3/RAF1/NOS3/GNAQ/PPP2R2A/BAX/RAC2/RHOA/CTSD/PLCB2/PIK3R1/BID	40
KEGG	hsa04510	Focal adhesion	60/1523	201/8135	7.523e-05	0.00359	0.002941	PAK6/HRAS/PIP5K1A/COL4A5/VAV3/FYN/LAMB4/ITGA2/ITGB6/PARVB/LAMC2/FLNA/ITGB3/IBSP/VTN/RAPGEF1/ROCK1/ITGA11/RELN/TLN1/PXN/PARVG/SHC4/MAP2K1/AKT1/ZYX/LAMA3/COL4A6/PIK3R2/PIP5K1C/MYLK4/COL6A1/RAP1B/ITGA5/ITGA3/PIK3R3/PRKCA/CAPN2/PAK2/THBS4/AKT3/FLT4/RAF1/VAV1/PDGFB/RAC2/HGF/PAK4/RHOA/FLNB/MYL2/GRB2/VASP/VCL/ACTN1/SPP1/PPP1R12C/PIK3R1/THBS1/COL6A6	60
KEGG	hsa04530	Tight junction	52/1523	169/8135	9.475e-05	0.003956	0.003241	OCLN/CGN/PPP2R2C/PRKCI/MARVELD2/CLDN1/PRKCE/CFTR/CLDN8/CLDN10/CD1A/ACTR3B/MYH14/CLDN4/DLG2/TJAP1/TJP2/HCLS1/RAP2C/TUBA3C/ARPC1B/TUBA4A/ACTR3C/SCRIB/MARVELD3/ROCK1/NEDD4/F11R/ARPC5/WAS/AMOTL1/ARHGEF2/PRKCZ/CRB3/MAGI1/PRKAA1/MPP5/LLGL2/ARPC5L/TUBA8/EZR/RAB8B/PPP2R2A/RHOA/MYL2/VASP/CACNA1D/TUBAL3/ACTN1/TJP1/PARD3/ARPC4	52
KEGG	hsa04611	Platelet activation	40/1523	124/8135	0.0001968	0.006715	0.005502	PLA2G4F/PRKCI/FCER1G/FYN/ITGA2/PLA2G4D/ITGB3/FCGR2A/MAPK12/PLA2G4C/GNAI2/ROCK1/GNAI1/TLN1/F2/FERMT3/PIK3R5/AKT1/P2RY12/ITPR2/P2RY1/PIK3R2/MAPK13/MYLK4/RAP1B/PIK3R3/PIK3CG/PRKCZ/ADCY1/AKT3/PTGS1/GP1BB/NOS3/GNAQ/RHOA/VASP/ADCY8/PLCB2/TBXAS1/PIK3R1	40
KEGG	hsa04360	Axon guidance	54/1523	182/8135	0.000201	0.006715	0.005502	NTNG2/PAK6/HRAS/EPHA1/BMP7/EFNA3/SEMA4B/FYN/RHOD/WNT4/SEMA4G/SLIT1/EFNA4/EPHB6/NGEF/GNAI2/EPHA2/EPHB3/LIMK2/ROCK1/SRGAP3/SEMA3B/GNAI1/NRP1/WNT5B/EFNA1/RASA1/PIK3R2/SRGAP1/RGMA/EFNB3/PLXNB3/PIK3R3/PRKCA/PPP3R1/PAK2/SEMA5B/PRKCZ/EPHB1/CFL1/RAF1/ROBO1/NCK1/DPYSL5/RAC2/PAK4/RHOA/WNT5A/LRRC4C/PLXNA3/FES/PIK3R1/NEO1/PARD3	54
KEGG	hsa04915	Estrogen signaling pathway	43/1523	138/8135	0.0002736	0.008308	0.006808	FKBP4/KRT17/KRT10/KRT23/KRT14/FKBP5/KRT15/CALML3/CALM3/KRT16/CALML5/HRAS/KRT9/HSP90AA1/TGFA/KRT19/KRT31/CREB3L2/KRT33A/GNAI2/KRT34/GNAI1/KRT25/KRT27/SHC4/MAP2K1/AKT1/ITPR2/PIK3R2/KCNJ6/PIK3R3/ADCY1/AKT3/RAF1/NOS3/GNAQ/GRB2/ADCY8/CTSD/PLCB2/PIK3R1/KRT35/ESR1	43
KEGG	hsa00280	Valine, leucine and isoleucine degradation	19/1523	48/8135	0.0005997	0.01669	0.01368	ACAT2/HMGCS1/ACADS/HMGCS2/BCAT1/AACS/MCCC1/ACAD8/HIBCH/IVD/PCCA/MCEE/EHHADH/BCKDHA/MCCC2/ALDH7A1/ALDH3A2/ACADSB/ACAA2	19
KEGG	hsa04062	Chemokine signaling pathway	54/1523	192/8135	0.0008471	0.02158	0.01769	CXCL5/HRAS/CCL27/VAV3/CXCL14/GNB3/CCR5/ELMO1/GNAI2/PREX1/ROCK1/ARRB2/GNAI1/PXN/FGR/CCL4/GNB1/PIK3R5/SHC4/MAP2K1/AKT1/PIK3R2/WAS/CCL21/CCL22/RAP1B/CCL19/CCR2/PIK3R3/PIK3CG/PRKCZ/GNG2/CXCL3/ADCY1/AKT3/RAF1/CCR1/VAV1/GRK5/GNAQ/RAC2/GNG10/GRK1/RHOA/CXCL6/GRB2/ADCY8/GNG4/PLCB2/DOCK2/HCK/PIK3R1/CCR10/PARD3	54
KEGG	hsa04015	Rap1 signaling pathway	58/1523	210/8135	0.0009047	0.02158	0.01769	CDH1/PRKCI/CALML3/CALM3/CALML5/HRAS/FGFR3/VAV3/FGFR2/EFNA3/ITGAM/EFNA4/ITGB3/ITGB2/MAPK12/GNAI2/EPHA2/CSF1/RAPGEF1/LPAR3/FGF16/GNAI1/TLN1/MAP2K1/FGF18/AKT1/EFNA1/P2RY1/PIK3R2/MAPK13/RAPGEF4/RAP1B/PFN1/PIK3R3/PRKCA/PRKCZ/DRD2/ADCY1/AKT3/MAGI1/FLT4/RAF1/RAPGEF5/FPR1/VAV1/CSF1R/PDGFB/GNAQ/RAC2/HGF/RHOA/VASP/ADCY8/PLCB2/GRIN2A/PIK3R1/PARD3/THBS1	58
KEGG	hsa05146	Amoebiasis	32/1523	102/8135	0.001396	0.03109	0.02548	SERPINB3/SERPINB13/COL4A5/SERPINB4/CD1A/ITGAM/LAMB4/LAMC2/ITGB2/GNAL/C9/RAB5C/LAMA3/MUC2/ARG1/COL4A6/PIK3R2/SERPINB10/RAB5B/TLR4/PIK3R3/PRKCA/CXCL3/ADCY1/IL10/GNAQ/TLR2/VCL/PLCB2/ACTN1/CD14/PIK3R1	32
KEGG	hsa05221	Acute myeloid leukemia	23/1523	67/8135	0.001718	0.03526	0.02889	HRAS/JUP/ITGAM/FCGR1A/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/CEBPE/AKT3/RAF1/CSF1R/SPI1/ZBTB16/GRB2/MPO/FLT3/BCL2A1/CD14/CCNA1/STAT5A/PIK3R1	23
KEGG	hsa05135	Yersinia infection	40/1523	137/8135	0.001795	0.03526	0.02889	PIP5K1A/VAV3/ACTR3B/FCGR2A/ELMO1/MAPK12/WIPF3/CD4/ARPC1B/RPS6KA6/ACTR3C/MAP2K4/ROCK1/PKN1/BAIAP2/WIPF1/PXN/MAP2K1/AKT1/ARPC5/PIK3R2/PIP5K1C/WAS/MAPK13/ITGA5/TLR4/PIK3R3/NLRC4/AKT3/IL10/VAV1/ARPC5L/GNAQ/RAC2/RHOA/ELMO2/PIK3R1/ARPC4/MAP3K7/NLRP3	40
KEGG	hsa04664	Fc epsilon RI signaling pathway	23/1523	68/8135	0.002145	0.0398	0.03261	PLA2G4F/HRAS/VAV3/FCER1G/FYN/PLA2G4D/ALOX5AP/MAPK12/PLA2G4C/MAP2K4/MAP2K1/AKT1/PIK3R2/FCER1A/MAPK13/PIK3R3/PRKCA/AKT3/RAF1/VAV1/RAC2/GRB2/PIK3R1	23
KEGG	hsa00590	Arachidonic acid metabolism	21/1523	61/8135	0.002576	0.0436	0.03572	ALOX12B/PLA2G4F/GPX2/PLA2G3/ALOX12/CYP2E1/CYP2J2/PLA2G4D/CYP4F2/PLA2G4C/CYP2C9/GPX1/PTGIS/PLA2G2D/PTGS1/LTC4S/PLA2G12A/CBR1/PLA2G1B/TBXAS1/GGT1	21
KEGG	hsa04670	Leukocyte transendothelial migration	34/1523	114/8135	0.002611	0.0436	0.03572	OCLN/CLDN1/VAV3/CLDN8/CLDN10/ITGAM/NCF4/CLDN4/CD99/ITGB2/MAPK12/GNAI2/ROCK1/GNAI1/PXN/F11R/CYBB/CYBA/PIK3R2/MAPK13/RAPGEF4/RAP1B/PIK3R3/PRKCA/CD99L2/VAV1/EZR/RAC2/RHOA/MYL2/VASP/VCL/ACTN1/PIK3R1	34
KEGG	hsa04151	PI3K-Akt signaling pathway	87/1523	354/8135	0.003093	0.04793	0.03927	ERBB3/PPP2R2C/HRAS/FGFR3/COL4A5/FGFR2/HSP90AA1/EFNA3/TGFA/LAMB4/CREB3L2/G6PC3/GNB3/ITGA2/ITGB6/LAMC2/EFNA4/NTF4/GH2/ITGB3/IBSP/PPP2R3A/VTN/EPHA2/CSF1/EPOR/NTRK1/ITGA11/LPAR3/PKN1/FGF16/RELN/GNB1/PIK3R5/MAP2K1/FGF18/AKT1/LAMA3/EFNA1/YWHAZ/COL4A6/PIK3R2/MTOR/CCNE2/LPAR6/COL6A1/ITGA5/ITGA3/TLR4/PIK3R3/PRKCA/PIK3CG/GNG2/THBS4/AKT3/BCL2L11/MAGI1/PRKAA1/FLT4/IFNAR2/RAF1/CSF1R/PDGFB/NOS3/CSH1/CSF3R/TLR2/IL7/PPP2R2A/IL3RA/PIK3AP1/GNG10/HGF/DDIT4/GRB2/SGK2/FLT3/GNG4/SPP1/PIK3R1/CRTC2/PHLPP1/THBS1/YWHAB/CHRM2/CSH2/COL6A6	87
KEGG	hsa04380	Osteoclast differentiation	37/1523	128/8135	0.003157	0.04793	0.03927	FCGR2B/TGFBR2/TYROBP/FYN/LILRB2/FCGR2C/NCF4/ITGB3/FCGR2A/MAPK12/TREM2/CSF1/LILRB4/LILRB1/LILRA3/FCGR1A/MAP2K1/AKT1/ACP5/LILRB5/CYBA/PIK3R2/LILRB3/MAPK13/LILRA6/PIK3R3/TNFSF11/PPP3R1/AKT3/IFNAR2/CSF1R/SPI1/TNFRSF11B/GRB2/OSCAR/PIK3R1/MAP3K7	37
KEGG	hsa04810	Regulation of actin cytoskeleton	57/1523	218/8135	0.003858	0.05603	0.04591	PAK6/HRAS/PIP5K1A/FGFR3/VAV3/FGFR2/ITGAM/ACTR3B/ITGA2/ITGB6/ITGB3/MYH14/NCKAP1L/ARHGEF6/ITGB2/IQGAP2/ARPC1B/ACTR3C/LIMK2/ROCK1/ITGA11/BAIAP2/FGF16/PXN/F2/MAP2K1/FGF18/GNA12/ARPC5/PIK3R2/PIP5K1C/KNG1/PIP4K2A/MYLK4/ITGA5/PFN1/ITGA3/PIK3R3/PAK2/CFL1/RAF1/VAV1/ARPC5L/EZR/PDGFB/RAC2/PIP4K2C/PAK4/RHOA/MYL2/ITGAD/VCL/ACTN1/PPP1R12C/PIK3R1/CHRM2/ARPC4	57
KEGG	hsa04371	Apelin signaling pathway	39/1523	139/8135	0.004389	0.06108	0.05005	CDH1/CALML3/CALM3/CALML5/HRAS/PRKCE/MEF2C/NOS1/GNB3/PIK3R4/SPHK2/GNAI2/RYR1/GNAI1/GNB1/PIK3R5/MAP2K1/AKT1/ITPR2/MTOR/MYLK4/SERPINE1/PIK3CG/GNG2/ADCY1/AKT3/PRKAA1/RAF1/RYR3/NOS3/GNAQ/GNG10/MAP1LC3A/MYL2/PPARGC1A/ADCY8/GNG4/PLCB2/SPP1	39
KEGG	hsa05133	Pertussis	24/1523	76/8135	0.004794	0.06393	0.05239	C1QB/C1QA/CXCL5/CALML3/CALM3/CALML5/ITGAM/C2/ITGB2/MAPK12/GNAI2/LY96/GNAI1/IRF8/C1QC/MAPK13/ITGA5/TLR4/IL10/CFL1/RHOA/CXCL6/CD14/NLRP3	24
KEGG	hsa05323	Rheumatoid arthritis	28/1523	93/8135	0.005167	0.06393	0.05239	CXCL5/ATP6V1C2/ATP6V0A4/HLA-DMA/HLA-DRB1/ITGB2/CSF1/CD86/HLA-DRA/ATP6V0E1/HLA-DMB/ACP5/ATP6V1E1/HLA-DRB4/TNFSF13/TCIRG1/TNFSF13B/TLR4/IL15/TNFSF11/CXCL3/IL17A/TLR2/ATP6V1G3/IL11/CXCL6/MMP3/HLA-DPA1	28
KEGG	hsa05170	Human immunodeficiency virus 1 infection	55/1523	212/8135	0.005336	0.06393	0.05239	CALML3/CALM3/PAK6/CALML5/HRAS/AP1M2/APOBEC3F/GNB3/CCR5/DDB1/MAPK12/TAPBP/GNAI2/CD4/HLA-B/SAMHD1/LIMK2/HLA-G/TNFRSF1B/BST2/APOBEC3C/GNAI1/PXN/GNB1/MAP2K1/CCNB1/AKT1/ITPR2/PIK3R2/MTOR/MAPK13/CUL4A/TLR4/HLA-F/PIK3R3/PRKCA/PPP3R1/HLA-C/PAK2/GNG2/AKT3/CFL1/RAF1/GNAQ/TLR2/BAX/RAC2/GNG10/PAK4/AP1M1/APOBEC3G/GNG4/PIK3R1/BID/MAP3K7	55
KEGG	hsa04142	Lysosome	37/1523	132/8135	0.005526	0.06393	0.05239	AGA/PSAPL1/ATP6V0A4/AP1M2/CLTB/TPP1/LAPTM5/CTSO/GGA2/CTSZ/SGSH/ACP2/AP4M1/NAGLU/GNPTG/ACP5/CTSS/HYAL4/PLA2G15/TCIRG1/GUSB/PPT2/MAN2B1/SLC11A1/ARSA/CTNS/IGF2R/MANBA/PSAP/AP1M1/GALC/GAA/CTSD/ABCB9/DNASE2/HYAL1/NAGPA	37
KEGG	hsa04921	Oxytocin signaling pathway	42/1523	154/8135	0.005551	0.06393	0.05239	PLA2G4F/CALML3/CALM3/CALML5/HRAS/MAP2K5/MEF2C/PLA2G4D/NPPA/PLA2G4C/GNAI2/CD38/RYR1/ROCK1/GNAI1/PIK3R5/MAP2K1/ITPR2/MYLK4/KCNJ12/KCNJ6/PRKCA/PPP3R1/CACNB4/PIK3CG/ADCY1/PRKAA1/RAF1/RYR3/NOS3/CACNG3/GNAQ/NPR1/CACNG2/RHOA/CACNB3/EEF2K/ADCY8/CACNA1D/CACNA2D4/PLCB2/PPP1R12C	42
KEGG	hsa05152	Tuberculosis	47/1523	180/8135	0.008406	0.09359	0.07669	CALML3/CALM3/CALML5/FCGR2B/ATP6V0A4/PLA2R1/FCER1G/ITGAM/HLA-DMA/HLA-DRB1/FCGR2C/CD74/FCGR2A/IL10RA/ITGB2/MAPK12/SPHK2/HLA-DRA/HLA-DMB/FCGR1A/RAB5C/AKT1/CTSS/TLR1/RFX5/CLEC4E/MAPK13/RAB5B/HLA-DRB4/TCIRG1/TLR4/CEBPG/PPP3R1/LSP1/AKT3/IL10/RAF1/TLR2/BAX/CYP27B1/RHOA/HLA-DPA1/CR1/CTSD/CORO1A/CD14/BID	47
KEGG	hsa04370	VEGF signaling pathway	19/1523	59/8135	0.009083	0.09786	0.08019	PLA2G4F/HRAS/PLA2G4D/MAPK12/SPHK2/PLA2G4C/PXN/MAP2K1/AKT1/PIK3R2/MAPK13/PIK3R3/PRKCA/PPP3R1/AKT3/RAF1/NOS3/RAC2/PIK3R1	19
KEGG	hsa05205	Proteoglycans in cancer	52/1523	205/8135	0.0105	0.1077	0.08825	ERBB3/WNT16/HRAS/VAV3/WNT3/ITGA2/WNT4/FLNA/ITGB3/FZD8/MAPK12/VTN/HCLS1/ROCK1/WNT1/PXN/MAP2K1/WNT5B/AKT1/ITPR2/PIK3R2/MTOR/MAPK13/SDC1/PDCD4/WNT10A/ITGA5/TLR4/PIK3R3/PRKCA/AKT3/MIR21/FZD6/RAF1/VAV1/EZR/TLR2/WNT2B/HGF/RHOA/FLNB/GRB2/WNT5A/SDC2/PLAUR/HOXD10/PPP1R12C/PIK3R1/ANK3/PTPN6/ESR1/THBS1	52
KEGG	hsa04972	Pancreatic secretion	29/1523	102/8135	0.01064	0.1077	0.08825	ATP1A1/CLCA2/PLA2G3/PRSS3/SLC12A2/CLCA4/CFTR/PRSS2/RAB27B/FXYD2/CD38/RAB11A/CA2/ITPR2/RAP1B/PRKCA/BST1/ADCY1/ATP1B1/CELA2B/PLA2G2D/GNAQ/PLA2G12A/RHOA/ADCY8/PLA2G1B/PLCB2/CELA2A/KCNQ1	29
KEGG	hsa04926	Relaxin signaling pathway	35/1523	129/8135	0.01164	0.1143	0.09367	HRAS/TGFBR2/COL4A5/NOS1/CREB3L2/GNB3/MAPK12/GNAI2/MAP2K4/ARRB2/GNAI1/GNB1/SHC4/MAP2K1/AKT1/COL4A6/PIK3R2/MAPK13/RLN3/PIK3R3/PRKCA/PRKCZ/GNG2/ADCY1/AKT3/RAF1/RXFP3/NOS3/GNG10/GRB2/ADCY8/MMP13/GNG4/PLCB2/PIK3R1	35
KEGG	hsa00591	Linoleic acid metabolism	11/1523	29/8135	0.01205	0.115	0.09423	PLA2G4F/PLA2G3/CYP2E1/CYP2J2/PLA2G4D/PLA2G4C/CYP2C9/PLA2G2D/PLA2G12A/CYP3A4/PLA2G1B	11
KEGG	hsa04640	Hematopoietic cell lineage	28/1523	99/8135	0.01284	0.1163	0.09532	CD1A/ITGAM/HLA-DMA/HLA-DRB1/ITGA2/ITGB3/CSF1/EPOR/CD4/HLA-DRA/CD38/HLA-DMB/FCGR1A/CD37/CD33/HLA-DRB4/ITGA5/ITGA3/CSF1R/GP1BB/CSF3R/IL7/IL3RA/IL11/HLA-DPA1/CR1/FLT3/CD14	28
KEGG	hsa00051	Fructose and mannose metabolism	12/1523	33/8135	0.01289	0.1163	0.09532	TSTA3/AKR1B10/ENOSF1/AKR1B1/SORD/FBP1/KHK/GMPPA/GMDS/HK3/PMM2/ALDOB	12
KEGG	hsa04662	B cell receptor signaling pathway	24/1523	82/8135	0.01326	0.1166	0.09553	HRAS/FCGR2B/VAV3/LILRB2/LILRB4/LILRB1/LILRA3/MAP2K1/AKT1/LILRB5/PIK3R2/LILRB3/LILRA6/PIK3R3/PPP3R1/AKT3/RAF1/VAV1/RAC2/PIK3AP1/GRB2/INPPL1/PIK3R1/PTPN6	24
KEGG	hsa04725	Cholinergic synapse	31/1523	113/8135	0.01441	0.1234	0.1011	HRAS/CHRNA3/FYN/CREB3L2/GNB3/GNAI2/GNAI1/GNB1/PIK3R5/MAP2K1/AKT1/KCNQ3/ITPR2/PIK3R2/KCNJ12/KCNJ6/PIK3R3/PRKCA/PIK3CG/GNG2/ADCY1/AKT3/GNAQ/GNG10/ADCY8/CACNA1D/GNG4/PLCB2/PIK3R1/KCNQ1/CHRM2	31
KEGG	hsa04014	Ras signaling pathway	57/1523	232/8135	0.01488	0.1242	0.1018	PLA2G4F/CALML3/CALM3/PLA2G3/PAK6/CALML5/HRAS/FGFR3/RASAL1/FGFR2/EFNA3/TGFA/GNB3/PLA2G4D/EFNA4/NTF4/RALBP1/PLA2G4C/EPHA2/CSF1/NTRK1/FGF16/GNB1/SHC4/MAP2K1/RAB5C/FGF18/AKT1/EFNA1/RASA1/PIK3R2/RAB5B/RAP1B/PIK3R3/PRKCA/PAK2/GNG2/AKT3/FLT4/RAF1/RAPGEF5/PLA2G2D/CSF1R/PDGFB/PLA2G12A/RAC2/GNG10/HGF/PAK4/HTR7/RHOA/GRB2/FLT3/PLA2G1B/GNG4/GRIN2A/PIK3R1	57
KEGG	hsa05330	Allograft rejection	13/1523	38/8135	0.01701	0.1386	0.1135	HLA-DMA/HLA-DRB1/CD86/HLA-B/HLA-DRA/HLA-G/HLA-DMB/CD40/HLA-DRB4/HLA-F/HLA-C/IL10/HLA-DPA1	13
KEGG	hsa04726	Serotonergic synapse	31/1523	115/8135	0.01848	0.145	0.1188	ALOX12B/PLA2G4F/HRAS/CYP2C18/ALOX12/CYP2J2/GNB3/PLA2G4D/PLA2G4C/GNAI2/HTR3A/CYP2C9/HTR2A/GNAI1/GNB1/MAP2K1/ITPR2/KCNJ6/PRKCA/GNG2/RAF1/PTGS1/GNAQ/GNG10/HTR7/CACNA1D/HTR6/GNG4/PLCB2/SLC18A1/GABRB2	31
KEGG	hsa04970	Salivary secretion	26/1523	93/8135	0.01867	0.145	0.1188	ATP1A1/CALML3/CALM3/CALML5/SLC12A2/TRPV6/NOS1/AQP5/FXYD2/MUC7/CD38/LYZ/ITPR2/CST4/PRKCA/BST1/ADCY1/ATP1B1/ADRA1A/RYR3/GNAQ/PRB1/ADCY8/PLCB2/STATH/CST2	26
KEGG	hsa04971	Gastric acid secretion	22/1523	76/8135	0.0196	0.1457	0.1194	ATP1A1/CALML3/CALM3/CALML5/CFTR/KCNK10/GNAI2/GNAI1/CA2/KCNJ10/ITPR2/MYLK4/PRKCA/ADCY1/ATP1B1/EZR/GNAQ/ADCY8/PLCB2/SST/KCNJ1/KCNQ1	22
KEGG	hsa00330	Arginine and proline metabolism	16/1523	51/8135	0.02054	0.1457	0.1194	NOS1/PRODH/GATM/P4HA3/ARG1/CKB/GOT2/GOT1/NOS3/SAT2/CKMT2/ALDH7A1/ALDH3A2/AMD1/LAP3/PYCR2	16
KEGG	hsa05310	Asthma	11/1523	31/8135	0.02055	0.1457	0.1194	FCER1G/HLA-DMA/HLA-DRB1/RNASE3/HLA-DRA/HLA-DMB/CD40/FCER1A/HLA-DRB4/IL10/HLA-DPA1	11
KEGG	hsa04610	Complement and coagulation cascades	24/1523	85/8135	0.02064	0.1457	0.1194	C1QB/C1QA/C3AR1/F2RL2/ITGAM/C5AR1/F12/VSIG4/C2/ITGB2/VTN/F10/C9/F2/F13A1/KNG1/C1QC/SERPINE1/CFHR3/SERPINC1/CR1/KLKB1/PLAUR/CD46	24
KEGG	hsa04973	Carbohydrate digestion and absorption	15/1523	47/8135	0.02093	0.1457	0.1194	ATP1A1/SLC5A1/SLC2A5/G6PC3/FXYD2/AKT1/PIK3R2/MGAM/PIK3R3/AKT3/ATP1B1/HK3/CACNA1D/PLCB2/PIK3R1	15
KEGG	hsa04929	GnRH secretion	19/1523	64/8135	0.02223	0.1512	0.1239	HRAS/KCNN3/ARRB2/MAP2K1/AKT1/HCN3/ITPR2/PIK3R2/KCNJ6/PIK3R3/PRKCA/AKT3/RAF1/GNAQ/LHB/CACNA1D/PLCB2/SPP1/PIK3R1	19
KEGG	hsa05140	Leishmaniasis	22/1523	77/8135	0.02274	0.1512	0.1239	ITGAM/HLA-DMA/HLA-DRB1/FCGR2C/NCF4/FCGR2A/ITGB2/MAPK12/HLA-DRA/HLA-DMB/FCGR1A/CYBB/CYBA/MAPK13/HLA-DRB4/TLR4/IL10/TLR2/HLA-DPA1/CR1/PTPN6/MAP3K7	22
KEGG	hsa05416	Viral myocarditis	18/1523	60/8135	0.02308	0.1512	0.1239	CXADR/HLA-DMA/FYN/HLA-DRB1/ITGB2/CD86/HLA-B/HLA-DRA/HLA-G/HLA-DMB/CD40/HLA-DRB4/HLA-F/HLA-C/RAC2/HLA-DPA1/BID/EIF4G2	18
KEGG	hsa00600	Sphingolipid metabolism	16/1523	52/8135	0.02466	0.1572	0.1288	SMPD3/PSAPL1/ACER1/DEGS1/DEGS2/SGPP2/SPHK2/KDSR/SMPD2/NEU3/SPTLC3/GAL3ST1/ARSA/PSAP/GALC/UGT8	16
KEGG	hsa05211	Renal cell carcinoma	20/1523	69/8135	0.02494	0.1572	0.1288	PAK6/HRAS/SLC2A1/TGFA/RAPGEF1/MAP2K1/AKT1/EGLN3/PIK3R2/RAP1B/PIK3R3/PAK2/AKT3/RAF1/FLCN/PDGFB/HGF/PAK4/GRB2/PIK3R1	20
KEGG	hsa04962	Vasopressin-regulated water reabsorption	14/1523	44/8135	0.02588	0.1573	0.1289	CREB3L2/AVPR2/RAB11B/DYNC1LI1/RAB11A/RAB5C/RAB5B/AQP3/DYNC2LI1/DCTN5/DYNC1I1/ARHGDIB/ARHGDIA/DYNLL1	14
KEGG	hsa00350	Tyrosine metabolism	12/1523	36/8135	0.02638	0.1573	0.1289	ALDH3B2/TYRP1/DCT/ALDH3A1/FAHD1/TYR/ADH7/HPD/GOT2/GOT1/ADH1B/TPO	12
KEGG	hsa00512	Mucin type O-glycan biosynthesis	12/1523	36/8135	0.02638	0.1573	0.1289	GCNT1/GALNT2/GALNT3/B4GALT5/ST3GAL1/ST6GALNAC2/GALNT10/GALNT14/ST3GAL2/GALNT11/GALNT7/ST6GALNAC4	12
KEGG	hsa05130	Pathogenic Escherichia coli infection	48/1523	197/8135	0.02756	0.1615	0.1323	OCLN/CLDN1/MYO5B/CLDN8/CLDN10/FYN/ACTR3B/MYH14/CLDN4/NCKAP1L/FCGR2A/MAPK12/WIPF3/HCLS1/TUBA3C/ARPC1B/TUBA4A/ACTR3C/ROCK1/BAIAP2L1/BAIAP2/WIPF1/F2/GNA12/TUBB3/ARPC5/MAPK13/MYO1F/TLR4/ARHGEF2/TMBIM6/PAK2/TUBB2A/MYO1H/NCK1/ARPC5L/TUBA8/EZR/BAX/MYO10/RHOA/MYO1B/TUBAL3/TJP1/PTPN6/ARPC4/MAP3K7/NLRP3	48
KEGG	hsa01212	Fatty acid metabolism	17/1523	57/8135	0.0283	0.163	0.1335	ACAT2/ACACA/ACSBG1/ACADS/ELOVL4/ACSL5/ACOX3/ELOVL1/ELOVL7/PPT2/MECR/ELOVL6/EHHADH/HSD17B4/SCD/ACADSB/ACAA2	17
KEGG	hsa04935	Growth hormone synthesis, secretion and action	31/1523	119/8135	0.02934	0.1641	0.1345	HRAS/CREB3L2/GH2/MAPK12/GNAI2/MAP2K4/GNAI1/SHC4/MAP2K1/AKT1/ITPR2/PIK3R2/MTOR/MAPK13/PIK3R3/PRKCA/ADCY1/AKT3/RAF1/CSH1/GNAQ/GRB2/GHRL/ADCY8/CACNA1D/PLCB2/SST/GHSR/STAT5A/PIK3R1/CSH2	31
KEGG	hsa04916	Melanogenesis	27/1523	101/8135	0.02948	0.1641	0.1345	WNT16/TYRP1/DCT/CALML3/CALM3/CALML5/HRAS/WNT3/CREB3L2/TYR/WNT4/FZD8/GNAI2/WNT1/GNAI1/MAP2K1/WNT5B/WNT10A/PRKCA/ADCY1/FZD6/RAF1/GNAQ/WNT2B/WNT5A/ADCY8/PLCB2	27
KEGG	hsa04672	Intestinal immune network for IgA production	15/1523	49/8135	0.03039	0.1664	0.1363	PIGR/HLA-DMA/HLA-DRB1/CD86/HLA-DRA/HLA-DMB/CD40/HLA-DRB4/TNFSF13/TNFSF13B/IL15/IL10/TNFRSF13B/HLA-DPA1/CCR10	15
KEGG	hsa04070	Phosphatidylinositol signaling system	26/1523	97/8135	0.03122	0.1682	0.1378	CALML3/CALM3/IPPK/PIK3C2G/CDS1/CALML5/PIP5K1A/PPIP5K1/ITPR2/PIK3R2/PIP5K1C/CDS2/PIP4K2A/PIK3R3/PRKCA/ITPKC/IMPA2/PIP4K2C/IMPA1/IP6K2/INPPL1/INPP5F/ITPK1/PLCB2/MTMR4/PIK3R1	26
KEGG	hsa04918	Thyroid hormone synthesis	21/1523	75/8135	0.03178	0.1685	0.138	ATP1A1/GPX2/DUOX1/DUOX2/CREB3L2/FXYD2/TTF2/SLC26A4/ITPR2/GPX1/TPO/PRKCA/PDIA4/ADCY1/ATP1B1/DUOXA2/GNAQ/GSR/CANX/ADCY8/PLCB2	21
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1523	14/8135	0.03252	0.1697	0.1391	CHST2/ST3GAL1/ST3GAL2/CHST1/B3GNT2/CHST6	6
KEGG	hsa04072	Phospholipase D signaling pathway	37/1523	148/8135	0.03405	0.175	0.1434	PLA2G4F/HRAS/PIP5K1A/FCER1G/AGPAT4/FYN/PLA2G4D/SPHK2/PLA2G4C/AVPR2/LPAR3/F2/PIK3R5/SHC4/MAP2K1/AKT1/GNA12/PIK3R2/PIP5K1C/FCER1A/MTOR/LPAR6/RAPGEF4/PIK3R3/PRKCA/PIK3CG/AVPR1A/ADCY1/AKT3/RAF1/PDGFB/RHOA/GRB2/ADCY8/AGPAT2/PLCB2/PIK3R1	37
KEGG	hsa05418	Fluid shear stress and atherosclerosis	35/1523	139/8135	0.0349	0.1766	0.1447	GSTT1/CALML3/CALM3/CALML5/GSTO2/MAP2K5/MEF2C/GSTA3/HSP90AA1/ITGB3/MAPK12/MAP2K4/AKT1/CYBA/PIK3R2/MAPK13/SDC1/NPPC/PIK3R3/SUMO3/ARHGEF2/PRKCZ/AKT3/SELE/PRKAA1/ACVR1/PDGFB/NOS3/GSTA4/RAC2/RHOA/SDC2/GSTM3/PIK3R1/MAP3K7	35
KEGG	hsa03250	Viral life cycle - HIV-1	18/1523	63/8135	0.03702	0.1846	0.1512	APOBEC3F/CCR5/SERINC3/SMARCB1/CD4/SAMHD1/VPS4B/BICD1/BICD2/BST2/APOBEC3C/SERINC5/TNPO3/CHMP6/APOBEC3G/FURIN/PPIA/MAP1S	18
KEGG	hsa05165	Human papillomavirus infection	75/1523	331/8135	0.03795	0.1864	0.1527	WNT16/PPP2R2C/ATP6V1C2/PRKCI/HRAS/ATP6V0A4/COL4A5/WNT3/LAMB4/CREB3L2/RBPJL/ITGA2/ITGB6/WNT4/LAMC2/ITGB3/IBSP/DLG2/PPP2R3A/RBPJ/FZD8/VTN/HLA-B/HLA-G/ATP6V0E1/SCRIB/WNT1/CSNK1A1/ITGA11/RELN/PXN/MAP2K1/WNT5B/AKT1/LAMA3/COL4A6/PIK3R2/TUBG1/ATP6V1E1/MTOR/CCNE2/WNT10A/COL6A1/ITGA5/TCIRG1/ITGA3/HLA-F/PIK3R3/HLA-C/PRKCZ/THBS4/AKT3/CRB3/HES5/MAGI1/FZD6/MPP5/LLGL2/IFNAR2/RAF1/PPP2R2A/BAX/WNT2B/ATP6V1G3/ISG15/GRB2/HES1/WNT5A/HDAC2/SPP1/CCNA1/PIK3R1/PARD3/THBS1/COL6A6	75
KEGG	hsa05132	Salmonella infection	58/1523	249/8135	0.03887	0.1881	0.1542	PIK3C2G/HRAS/HSP90AA1/ACTR3B/FLNA/NCKAP1L/ELMO1/MAPK12/TUBA3C/ARPC1B/TUBA4A/LY96/ACTR3C/DYNLT1/MAP2K4/AHNAK2/PKN1/DYNC1LI1/MAP2K1/RAB5C/DYNLRB2/AKT1/KLC3/TUBB3/ARPC5/MAPK13/RAB5B/PFN1/TLR4/PTPRC/FBXO22/DYNC2LI1/PIK3CG/NLRC4/AKT3/DCTN5/DYNC1I1/CSE1L/TUBB2A/RAF1/ARPC5L/GSDMD/S100A10/TUBA8/KPNA3/DYNLL1/TLR2/BAX/RHOA/FLNB/MYL2/MLKL/ELMO2/TUBAL3/CD14/ARPC4/MAP3K7/NLRP3	58
KEGG	hsa00900	Terpenoid backbone biosynthesis	8/1523	22/8135	0.03952	0.1886	0.1545	ACAT2/HMGCS1/HMGCR/HMGCS2/FDPS/PMVK/PCYOX1/ICMT	8
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	37/1523	150/8135	0.041	0.1929	0.1581	SCN1B/ATP1A1/PPP2R2C/CALML3/CALM3/CALML5/SCN7A/CREB3L2/FXYD2/PPP2R3A/MAPK12/GNAI2/TNNT2/GNAI1/PIK3R5/AKT1/MAPK13/RAPGEF4/PRKCA/CACNB4/PIK3CG/ADCY1/AKT3/ATP1B1/ADRA1A/CACNG3/GNAQ/PPP2R2A/CACNG2/MYL2/CACNB3/ADCY8/CACNA1D/CACNA2D4/CREM/PLCB2/KCNQ1	37
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	52/1523	222/8135	0.04425	0.2043	0.1674	POLB/HRAS/TGFBR2/SLC2A1/HLA-DMA/CREB3L2/HLA-DRB1/ITGB2/CD4/CDC26/HLA-B/HLA-DRA/HLA-G/SLC25A5/MAP2K4/HLA-DMB/TLN1/CD40/NRP1/MAP2K1/AKT1/PIK3R2/FDPS/CCNE2/HLA-DRB4/HLA-F/PIK3R3/IL15/PPP3R1/HLA-C/ADCY1/MAP3K3/AKT3/ANAPC7/ANAPC1/E2F3/RANBP3/CRTC3/SPI1/BAX/HLA-DPA1/CANX/ADCY8/MSX2/CCNA1/PTTG1/STAT5A/PIK3R1/CDKN2A/MAD1L1/CDC16/CRTC2	52
KEGG	hsa04144	Endocytosis	58/1523	251/8135	0.04466	0.2043	0.1674	CHMP4C/PRKCI/EPN3/HRAS/PIP5K1A/FGFR3/TGFBR2/CLTB/FGFR2/CAPZA3/ACTR3B/CCR5/IQSEC1/AMPH/RAB22A/WIPF3/ARPC1B/SMAP2/HLA-B/VPS4B/SH3GL3/ACTR3C/HLA-G/RAB11B/ARRB2/NEDD4/WIPF1/RAB11A/RAB5C/EPN2/PSD2/ARPC5/PIP5K1C/AP2A2/RAB31/RAB5B/VPS35/CBLC/HLA-F/DAB2/CHMP6/HLA-C/PRKCZ/ARFGAP1/RAB11FIP2/SH3KBP1/GRK5/ARPC5L/IGF2R/GRK1/RHOA/RAB11FIP1/AP2M1/SNX4/RAB4A/PARD3/ARPC4/IQSEC3	58
KEGG	hsa04924	Renin secretion	19/1523	69/8135	0.04654	0.21	0.1721	CLCA2/CALML3/CALM3/CALML5/CLCA4/ACE/NPPA/GNAI2/GNAI1/PTGER2/ITPR2/PPP3R1/EDN3/GNAQ/NPR1/CACNA1D/PLCB2/REN/ADCYAP1	19
KEGG	hsa04917	Prolactin signaling pathway	19/1523	70/8135	0.05308	0.2304	0.1888	ELF5/HRAS/SOCS7/MAPK12/SHC4/MAP2K1/AKT1/PIK3R2/MAPK13/PIK3R3/TNFSF11/AKT3/RAF1/LHB/GRB2/STAT5A/SOCS5/PIK3R1/ESR1	19
KEGG	hsa05230	Central carbon metabolism in cancer	19/1523	70/8135	0.05308	0.2304	0.1888	HRAS/FGFR3/SLC2A1/FGFR2/SLC16A3/NTRK1/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/AKT3/RAF1/HK3/FLT3/PIK3R1/LDHA/PDHA1/RET	19
KEGG	hsa04540	Gap junction	23/1523	88/8135	0.05311	0.2304	0.1888	HRAS/MAP2K5/GNAI2/TUBA3C/TUBA4A/HTR2A/GNAI1/MAP2K1/TUBB3/ITPR2/PRKCA/DRD2/ADCY1/TUBB2A/RAF1/TUBA8/PDGFB/GNAQ/GRB2/ADCY8/TUBAL3/PLCB2/TJP1	23
KEGG	hsa05142	Chagas disease	26/1523	102/8135	0.05485	0.2349	0.1925	C1QB/C1QA/PPP2R2C/TGFBR2/ACE/MAPK12/GNAI2/GNAL/MAP2K4/GNAI1/AKT1/PIK3R2/KNG1/C1QC/MAPK13/TLR4/PIK3R3/SERPINE1/ADCY1/AKT3/IL10/GNAQ/TLR2/PPP2R2A/PLCB2/PIK3R1	26
KEGG	hsa05214	Glioma	20/1523	75/8135	0.0567	0.2397	0.1964	CALML3/CALM3/CALML5/HRAS/TGFA/SHC4/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/PRKCA/AKT3/E2F3/RAF1/PDGFB/BAX/GRB2/PIK3R1/CDKN2A	20
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	25/1523	98/8135	0.05839	0.2438	0.1998	PLA2G4F/CALML3/CALM3/CALML5/F2RL1/PRKCE/ALOX12/CYP2J2/PLA2G4D/MAPK12/PLA2G4C/NTRK1/HTR2A/PTGER2/ITPR2/PIK3R2/KNG1/MAPK13/PIK3R3/PRKCA/ADCY1/GNAQ/ADCY8/PLCB2/PIK3R1	25
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	14/1523	49/8135	0.06123	0.2514	0.206	CYB5R2/TSTA3/GPI/GMPPA/CHIT1/CYB5R3/GMDS/PGM2/AMDHD2/CMAS/HK3/PMM2/CYB5R1/UAP1L1	14
KEGG	hsa00640	Propanoate metabolism	10/1523	32/8135	0.06173	0.2514	0.206	ACACA/ACADS/ACOX3/HIBCH/PCCA/MCEE/EHHADH/BCKDHA/LDHA/SUCLG1	10
KEGG	hsa04012	ErbB signaling pathway	22/1523	85/8135	0.06327	0.2546	0.2086	ERBB3/PAK6/HRAS/TGFA/MAP2K4/NRG3/SHC4/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/PRKCA/PAK2/AKT3/RAF1/NCK1/PAK4/GRB2/NRG4/STAT5A/PIK3R1	22
KEGG	hsa05110	Vibrio cholerae infection	14/1523	50/8135	0.07098	0.272	0.2228	ATP6V1C2/ATP6V0A4/SLC12A2/CFTR/TJP2/ATP6V0E1/ATP6V1E1/TCIRG1/PRKCA/PDIA4/ATP6V1G3/SEC61A1/TJP1/KCNQ1	14
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	11/1523	37/8135	0.0711	0.272	0.2228	ATP1A1/SFN/SCNN1G/FXYD2/SCNN1B/PIK3R2/PIK3R3/PRKCA/ATP1B1/KCNJ1/PIK3R1	11
KEGG	hsa05143	African trypanosomiasis	11/1523	37/8135	0.0711	0.272	0.2228	F2RL1/NPPA/APOL1/HPR/KNG1/APOA1/PRKCA/IL10/SELE/GNAQ/PLCB2	11
KEGG	hsa05224	Breast cancer	35/1523	147/8135	0.07122	0.272	0.2228	WNT16/HRAS/WNT3/WNT4/DLL3/FZD8/WNT1/CSNK1A1/FGF16/SHC4/MAP2K1/FGF18/WNT5B/AKT1/DLL1/FRAT1/PIK3R2/MTOR/WNT10A/PIK3R3/TNFSF11/AKT3/HES5/FZD6/E2F3/FLT4/RAF1/BAX/WNT2B/GRB2/HES1/WNT5A/JAG2/PIK3R1/ESR1	35
KEGG	hsa05100	Bacterial invasion of epithelial cells	20/1523	77/8135	0.0718	0.272	0.2228	CDH1/CLTB/ACTR3B/ELMO3/ELMO1/HCLS1/ARPC1B/ACTR3C/PXN/SHC4/ARPC5/PIK3R2/ITGA5/PIK3R3/ARPC5L/RHOA/ELMO2/VCL/PIK3R1/ARPC4	20
KEGG	hsa00830	Retinol metabolism	18/1523	68/8135	0.07247	0.272	0.2228	UGT1A6/RDH12/CYP2C18/RDH16/SDR16C5/HSD17B6/CYP3A5/RDH13/RETSAT/CYP3A7/ADH7/CYP2C9/RPE65/RDH10/ADH1B/RDH8/DHRS9/CYP3A4	18
KEGG	hsa04390	Hippo signaling pathway	37/1523	157/8135	0.07386	0.2737	0.2243	CDH1/WNT16/PPP2R2C/WWC1/PRKCI/TGFBR2/BMP7/WNT3/WNT4/DLG2/TEAD3/ITGB2/FZD8/LIMD1/SCRIB/WNT1/WNT5B/GLI2/YWHAZ/BMP6/RASSF6/WNT10A/SERPINE1/PRKCZ/FZD6/MPP5/LLGL2/BMP8B/PPP2R2A/WNT2B/DLG4/WNT5A/SAV1/BMP2/TEAD4/PARD3/YWHAB	37
KEGG	hsa04630	JAK-STAT signaling pathway	38/1523	162/8135	0.07507	0.2737	0.2243	HRAS/IL22RA1/IL20RB/IL20RA/SOCS7/GH2/IL10RA/IL6ST/EPOR/IL23R/IL22/IL20/IL27RA/AKT1/PIK3R2/MTOR/CSF2RB/PIK3R3/IL15/AKT3/IL10/IFNAR2/RAF1/PDGFB/CSH1/CSF3R/IL7/IL3RA/IL11/IL22RA2/GRB2/TSLP/STAT5A/IL13RA2/SOCS5/PIK3R1/PTPN6/CSH2	38
KEGG	hsa05163	Human cytomegalovirus infection	51/1523	225/8135	0.07563	0.2737	0.2243	CALML3/CALM3/CALML5/HRAS/CREB3L2/GNB3/CCR5/ITGB3/IL10RA/MAPK12/TAPBP/GNAI2/HLA-B/HLA-G/ROCK1/GNAI1/PXN/CCL4/GNB1/MAP2K1/AKT1/GNA12/PTGER2/ITPR2/PIK3R2/MTOR/MAPK13/AKAP13/HLA-F/PIK3R3/PRKCA/PPP3R1/HLA-C/GNG2/ADCY1/AKT3/E2F3/RAF1/CCR1/GNAQ/BAX/RAC2/GNG10/RHOA/GRB2/ADCY8/GNG4/PLCB2/PIK3R1/BID/CDKN2A	51
KEGG	hsa04022	cGMP-PKG signaling pathway	39/1523	167/8135	0.07621	0.2737	0.2243	ATP1A1/CALML3/CALM3/ADORA3/CALML5/PRKCE/MEF2C/CREB3L2/FXYD2/NPPA/GNAI2/CNGA1/SLC25A5/ROCK1/GNAI1/PIK3R5/MAP2K1/AKT1/GNA12/ITPR2/KNG1/MYLK4/NPPC/PPP3R1/PIK3CG/ADCY1/AKT3/GTF2IRD1/ATP1B1/RAF1/ADRA1A/NOS3/GNAQ/NPR1/RHOA/VASP/ADCY8/CACNA1D/PLCB2	39
KEGG	hsa04270	Vascular smooth muscle contraction	32/1523	134/8135	0.07899	0.2799	0.2294	PLA2G4F/CALML3/CALM3/PLA2G3/CALML5/PRKCE/PLA2G4D/MYH14/NPPA/PLA2G4C/ROCK1/MAP2K1/GNA12/ITPR2/MYLK4/NPPC/PRKCA/AVPR1A/ADCY1/EDN3/RAF1/PLA2G2D/ADRA1A/GNAQ/PLA2G12A/NPR1/RHOA/ADCY8/CACNA1D/PLA2G1B/PLCB2/PPP1R12C	32
KEGG	hsa00592	alpha-Linolenic acid metabolism	8/1523	25/8135	0.07972	0.2799	0.2294	PLA2G4F/PLA2G3/PLA2G4D/PLA2G4C/ACOX3/PLA2G2D/PLA2G12A/PLA2G1B	8
KEGG	hsa00910	Nitrogen metabolism	6/1523	17/8135	0.08127	0.2799	0.2294	CA14/CA6/CA12/CA2/CA13/GLUL	6
KEGG	hsa00770	Pantothenate and CoA biosynthesis	7/1523	21/8135	0.0813	0.2799	0.2294	BCAT1/PANK1/VNN1/VNN2/PANK2/PANK3/ALDH3A2	7
KEGG	hsa04730	Long-term depression	16/1523	60/8135	0.08222	0.2802	0.2296	PLA2G4F/HRAS/NOS1/PLA2G4D/PLA2G4C/GNAI2/RYR1/GNAI1/MAP2K1/GNA12/ITPR2/PRKCA/RAF1/CRHR1/GNAQ/PLCB2	16
KEGG	hsa04512	ECM-receptor interaction	22/1523	88/8135	0.08693	0.2924	0.2396	COL4A5/LAMB4/FREM2/ITGA2/ITGB6/LAMC2/ITGB3/IBSP/VTN/ITGA11/RELN/LAMA3/COL4A6/SDC1/COL6A1/ITGA5/ITGA3/THBS4/GP1BB/SPP1/THBS1/COL6A6	22
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	20/1523	79/8135	0.08941	0.2924	0.2396	ERBB3/HRAS/FGFR3/FGFR2/TGFA/SHC4/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/PRKCA/AKT3/BCL2L11/RAF1/PDGFB/BAX/HGF/GRB2/PIK3R1	20
KEGG	hsa04912	GnRH signaling pathway	23/1523	93/8135	0.08987	0.2924	0.2396	PLA2G4F/CALML3/CALM3/CALML5/HRAS/PLA2G4D/MAPK12/PLA2G4C/MAP2K4/MAP3K4/MAP2K1/ITPR2/MAPK13/PRKCA/ADCY1/MAP3K3/RAF1/GNAQ/LHB/GRB2/ADCY8/CACNA1D/PLCB2	23
KEGG	hsa00071	Fatty acid degradation	12/1523	43/8135	0.09224	0.2924	0.2396	ACAT2/ACSBG1/ACADS/ACSL5/ADH7/ACOX3/ADH1B/EHHADH/ALDH7A1/ALDH3A2/ACADSB/ACAA2	12
KEGG	hsa04940	Type I diabetes mellitus	12/1523	43/8135	0.09224	0.2924	0.2396	HLA-DMA/HLA-DRB1/CD86/HLA-B/HLA-DRA/HLA-G/HLA-DMB/HLA-DRB4/HLA-F/HLA-C/PTPRN2/HLA-DPA1	12
KEGG	hsa04975	Fat digestion and absorption	12/1523	43/8135	0.09224	0.2924	0.2396	ACAT2/PLA2G3/DGAT2/GOT2/SLC27A4/APOA1/PLA2G2D/LIPF/PLA2G12A/CLPS/PLA2G1B/AGPAT2	12
KEGG	hsa05231	Choline metabolism in cancer	24/1523	98/8135	0.09259	0.2924	0.2396	PLA2G4F/HRAS/PIP5K1A/PLA2G4D/PLA2G4C/SLC44A5/SLC22A3/SLC22A5/SLC44A3/MAP2K1/AKT1/PIK3R2/PIP5K1C/MTOR/WAS/PIK3R3/PRKCA/AKT3/RAF1/PDGFB/RAC2/GRB2/PIK3R1/PCYT1A	24
KEGG	hsa04210	Apoptosis	32/1523	136/8135	0.09281	0.2924	0.2396	TP53AIP1/HRAS/CTSO/CTSZ/TUBA3C/NTRK1/TUBA4A/CASP2/PTPN13/MAP2K1/AKT1/CTSS/ITPR2/PIK3R2/CAPN1/CSF2RB/PIK3R3/CAPN2/AKT3/BCL2L11/PARP3/RAF1/TUBA8/IL3RA/BAX/DAB2IP/CTSD/TUBAL3/BCL2A1/PARP4/PIK3R1/BID	32
KEGG	hsa04150	mTOR signaling pathway	36/1523	156/8135	0.09818	0.3054	0.2503	WNT16/ATP6V1C2/HRAS/WNT3/RRAGC/WNT4/CLIP1/FZD8/RPS6KA6/WNT1/MAP2K1/WNT5B/AKT1/PIK3R2/MAPKAP1/ATP6V1E1/MTOR/WNT10A/PIK3R3/PRKCA/AKT3/PRKAA1/FZD6/GRB10/PRR5L/RAF1/LPIN2/FLCN/WNT2B/ATP6V1G3/RHOA/DDIT4/GRB2/WNT5A/PIK3R1/RICTOR	36
KEGG	hsa04728	Dopaminergic synapse	31/1523	132/8135	0.09875	0.3054	0.2503	PPP2R2C/CALML3/CALM3/CALML5/CREB3L2/GNB3/PPP2R3A/MAPK12/GNAI2/GNAL/ARRB2/GNAI1/GNB1/AKT1/ITPR2/MAPK13/CLOCK/KCNJ6/PRKCA/DRD2/GNG2/AKT3/GNAQ/PPP2R2A/GNG10/CACNA1D/GNG4/PLCB2/SLC18A1/GRIN2A/PPP1R1B	31
KEGG	hsa00220	Arginine biosynthesis	7/1523	22/8135	0.1008	0.3072	0.2517	NOS1/GPT2/ARG1/GOT2/GOT1/GLUL/NOS3	7
KEGG	hsa04520	Adherens junction	18/1523	71/8135	0.1021	0.3072	0.2517	CDH1/TGFBR2/CSNK2A2/FYN/NLK/SSX2IP/LMO7/PTPRF/BAIAP2/WAS/RAC2/RHOA/VCL/ACTN1/TJP1/PARD3/PTPN6/MAP3K7	18
KEGG	hsa01232	Nucleotide metabolism	21/1523	85/8135	0.1025	0.3072	0.2517	ADK/GDA/HDDC2/AK7/ENTPD3/XDH/DGUOK/ENTPD6/NT5M/NME4/TK2/NUDT16/CTPS2/GMPS/ASMTL/CANT1/CDA/UPP1/TYMS/GMPR2/ENTPD1	21
KEGG	hsa00511	Other glycan degradation	6/1523	18/8135	0.1034	0.3072	0.2517	AGA/NEU3/MAN2B2/MAN2C1/MAN2B1/MANBA	6
KEGG	hsa04660	T cell receptor signaling pathway	25/1523	104/8135	0.1039	0.3072	0.2517	PAK6/HRAS/VAV3/FYN/MAPK12/CD4/MAP2K1/AKT1/PIK3R2/MAPK13/PTPRC/PIK3R3/PPP3R1/PAK2/AKT3/IL10/RAF1/NCK1/VAV1/PAK4/RHOA/GRB2/PIK3R1/PTPN6/MAP3K7	25
KEGG	hsa05320	Autoimmune thyroid disease	14/1523	53/8135	0.1061	0.3109	0.2547	HLA-DMA/HLA-DRB1/CD86/HLA-B/HLA-DRA/HLA-G/HLA-DMB/CD40/HLA-DRB4/HLA-F/TPO/HLA-C/IL10/HLA-DPA1	14
KEGG	hsa04024	cAMP signaling pathway	49/1523	221/8135	0.108	0.3135	0.2569	ATP1A1/CALML3/CALM3/CALML5/VAV3/CFTR/CREB3L2/FXYD2/NPPA/GNAI2/CNGA1/SUCNR1/ROCK1/ACOX3/GNAI1/MAP2K1/AKT1/PTGER2/SOX9/PIK3R2/RAPGEF4/RAP1B/PIK3R3/DRD2/ADCY1/AKT3/EDN3/ATP1B1/RAF1/VAV1/NPY1R/NPY/CRHR1/RAC2/NPR1/PDE4A/LHB/RHOA/GHRL/ADCY8/CACNA1D/HTR6/GRIN2A/SST/GHSR/PIK3R1/ADCYAP1/PPP1R1B/CHRM2	49
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	24/1523	100/8135	0.1109	0.3193	0.2616	CXCL5/IL22RA1/CCL27/IL20RB/IL20RA/CXCL14/CCR5/IL10RA/IL6ST/CSF1/TNFRSF1B/IL20/CCL4/CCL21/CCL22/CCL19/CCR2/CXCL3/IL10/TNFRSF10D/CCR1/CSF1R/CXCL6/CCR10	24
KEGG	hsa00480	Glutathione metabolism	15/1523	58/8135	0.1118	0.3193	0.2616	GGT6/GSTT1/GPX2/GSTO2/GGCT/GSTA3/GPX1/GPX4/GSTA4/GSR/TXNDC12/LANCL1/GSTM3/LAP3/GGT1	15
KEGG	hsa00565	Ether lipid metabolism	13/1523	49/8135	0.1135	0.3212	0.2632	PLA2G4F/PLA2G3/PLA2G4D/PLD3/PLA2G4C/GDPD3/LPCAT1/PAFAH1B1/GAL3ST1/PLA2G2D/PLA2G12A/PLA2G1B/UGT8	13
KEGG	hsa04966	Collecting duct acid secretion	8/1523	27/8135	0.1164	0.3267	0.2677	ATP6V1C2/ATP6V0A4/ATP6V0E1/CA2/SLC12A7/ATP6V1E1/TCIRG1/ATP6V1G3	8
KEGG	hsa05226	Gastric cancer	34/1523	149/8135	0.1188	0.3308	0.271	CDH1/WNT16/HRAS/TGFBR2/FGFR2/JUP/WNT3/WNT4/FZD8/WNT1/CSNK1A1/FGF16/SHC4/MAP2K1/FGF18/WNT5B/AKT1/MUC2/FRAT1/PIK3R2/MTOR/CCNE2/WNT10A/PIK3R3/AKT3/FZD6/E2F3/RAF1/BAX/WNT2B/HGF/GRB2/WNT5A/PIK3R1	34
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1523	106/8135	0.1231	0.3399	0.2785	BGLAP/MEF2C/CREB3L2/SLC34A2/GNAI2/ARRB2/GNAI1/MAP2K1/GNA12/ITPR2/AKAP13/PRKCA/TNFSF11/ADCY1/RAF1/GNAQ/PDE4A/CYP27B1/MMP15/RHOA/CYP24A1/ADCY8/MMP13/PLCB2/GATA3	25
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	43/1523	194/8135	0.1258	0.3445	0.2823	CALML3/CALM3/CALML5/HRAS/GNB3/CCR5/MAPK12/IL6ST/CD86/HLA-B/HLA-G/MAP2K4/PREX1/GNB1/PIK3R5/MAP2K1/AKT1/ITPR2/PIK3R2/MTOR/MAPK13/MICB/HLA-F/PIK3R3/PPP3R1/PIK3CG/HLA-C/GNG2/CXCL3/AKT3/E2F3/IFNAR2/RAF1/CCR1/PDGFB/BAX/GNG10/MAP1LC3A/RPS27A/GNG4/HCK/PIK3R1/BID	43
KEGG	hsa05144	Malaria	13/1523	50/8135	0.1284	0.3469	0.2842	ITGB2/GYPC/CD40/SDC1/TLR4/THBS4/IL10/SELE/TLR2/HGF/CR1/SDC2/THBS1	13
KEGG	hsa04010	MAPK signaling pathway	63/1523	294/8135	0.1288	0.3469	0.2842	ERBB3/PLA2G4F/HRAS/FGFR3/TGFBR2/MAP2K5/MEF2C/FGFR2/EFNA3/TGFA/MAPT/MAP3K12/PLA2G4D/FLNA/EFNA4/NTF4/MAPK12/PLA2G4C/NLK/EPHA2/CSF1/NTRK1/RPS6KA6/MAP2K4/TAOK3/ARRB2/FGF16/MKNK1/MAP3K4/MAP2K1/MAP3K11/FGF18/AKT1/GNA12/EFNA1/RASA1/MAP4K4/MAPK13/RAP1B/MAPK8IP1/PRKCA/PPP3R1/CACNB4/PAK2/MAP3K3/AKT3/FLT4/RAF1/CSF1R/PDGFB/CACNG3/RAC2/CACNG2/HGF/FLNB/GRB2/CACNB3/CACNA1D/CACNA2D4/FLT3/CD14/MAPK8IP3/MAP3K7	63
KEGG	hsa05219	Bladder cancer	11/1523	41/8135	0.1301	0.3475	0.2847	CDH1/HRAS/FGFR3/MAP2K1/E2F3/RAF1/DAPK3/DAPK1/CDKN2A/THBS1/UPK3A	11
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	30/1523	131/8135	0.1316	0.3489	0.2859	HRAS/VAV3/FCER1G/TYROBP/FYN/RAET1E/ITGB2/ICAM2/HLA-B/HCST/HLA-G/SHC4/MAP2K1/PIK3R2/MICB/PIK3R3/PRKCA/PPP3R1/HLA-C/IFNAR2/RAF1/VAV1/RAC2/GRB2/NCR1/PIK3R1/BID/CD48/ULBP2/PTPN6	30
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1523	15/8135	0.1327	0.349	0.2859	ST3GAL1/ST6GALNAC6/ST3GAL2/ST3GAL5/ST6GALNAC4	5
KEGG	hsa00650	Butanoate metabolism	8/1523	28/8135	0.1376	0.359	0.2942	ACAT2/HMGCS1/L2HGDH/ACADS/HMGCS2/AACS/BDH1/EHHADH	8
KEGG	hsa01522	Endocrine resistance	23/1523	98/8135	0.1403	0.3633	0.2977	HRAS/DLL3/MAPK12/SHC4/MAP2K1/AKT1/DLL1/PIK3R2/MTOR/MAPK13/PIK3R3/ADCY1/AKT3/E2F3/RAF1/BAX/GRB2/ADCY8/CARM1/JAG2/PIK3R1/CDKN2A/ESR1	23
KEGG	hsa04913	Ovarian steroidogenesis	13/1523	51/8135	0.1444	0.3685	0.3019	PLA2G4F/HSD17B2/CYP2J2/PLA2G4D/STAR/PLA2G4C/CYP11A1/BMP6/ADCY1/HSD17B7/LHB/ADCY8/HSD3B1	13
KEGG	hsa04977	Vitamin digestion and absorption	7/1523	24/8135	0.1466	0.3685	0.3019	SLC23A1/FOLH1/SLC46A1/TCN2/APOA1/SLC19A2/BTD	7
KEGG	hsa04310	Wnt signaling pathway	37/1523	167/8135	0.1473	0.3685	0.3019	WNT16/RNF43/CSNK2A2/RSPO1/LGR5/WNT3/WNT4/WIF1/DKK2/LGR4/FRZB/VANGL2/FZD8/NLK/CTNNBIP1/DAAM1/WNT1/CSNK1A1/WNT5B/FRAT1/VANGL1/WNT10A/DKK1/RSPO2/ZNRF3/PRKCA/PPP3R1/SENP2/FZD6/RAC2/WNT2B/RHOA/SFRP4/WNT5A/PLCB2/MAP3K7/TLE6	37
KEGG	hsa04727	GABAergic synapse	21/1523	89/8135	0.1475	0.3685	0.3019	SLC6A11/GABRP/GNB3/GABRR2/GNAI2/SLC38A2/GNAI1/GNB1/SLC6A13/KCNJ6/GLUL/PRKCA/GNG2/ADCY1/GNG10/GABRR1/ADCY8/CACNA1D/GNG4/GABRB2/GABRE	21
KEGG	hsa05332	Graft-versus-host disease	11/1523	42/8135	0.148	0.3685	0.3019	HLA-DMA/HLA-DRB1/CD86/HLA-B/HLA-DRA/HLA-G/HLA-DMB/HLA-DRB4/HLA-F/HLA-C/HLA-DPA1	11
KEGG	hsa03410	Base excision repair	9/1523	33/8135	0.1496	0.3685	0.3019	POLB/MPG/POLL/POLD2/NEIL3/PARP3/TDG/POLD4/PARP4	9
KEGG	hsa04923	Regulation of lipolysis in adipocytes	14/1523	56/8135	0.15	0.3685	0.3019	NPPA/GNAI2/GNAI1/AKT1/PIK3R2/PIK3R3/ADCY1/AKT3/NPY1R/PTGS1/NPY/NPR1/ADCY8/PIK3R1	14
KEGG	hsa05225	Hepatocellular carcinoma	37/1523	168/8135	0.1565	0.3805	0.3118	WNT16/GSTT1/HRAS/TGFBR2/GSTO2/GSTA3/TGFA/WNT3/WNT4/SMARCB1/FZD8/WNT1/CSNK1A1/SHC4/MAP2K1/WNT5B/AKT1/FRAT1/PIK3R2/MTOR/WNT10A/PIK3R3/PRKCA/AKT3/FZD6/E2F3/RAF1/GSTA4/BAX/WNT2B/HGF/GRB2/WNT5A/GSTM3/PIK3R1/CDKN2A/SMARCA4	37
KEGG	hsa04724	Glutamatergic synapse	26/1523	114/8135	0.1572	0.3805	0.3118	PLA2G4F/SLC1A6/HOMER2/GNB3/PLA2G4D/PLA2G4C/GNAI2/SLC38A2/GNAI1/GNB1/ITPR2/SHANK2/HOMER1/GLUL/PRKCA/PPP3R1/GNG2/ADCY1/GNAQ/GNG10/DLG4/ADCY8/CACNA1D/GNG4/PLCB2/GRIN2A	26
KEGG	hsa04722	Neurotrophin signaling pathway	27/1523	119/8135	0.1586	0.3811	0.3123	CALML3/CALM3/CALML5/HRAS/MAP2K5/NTF4/MAPK12/NTRK1/RAPGEF1/RPS6KA6/SHC4/MAP2K1/AKT1/PIK3R2/MAPK13/RAP1B/SH2B3/PIK3R3/MAP3K3/AKT3/RAF1/ARHGDIB/ARHGDIA/BAX/RHOA/GRB2/PIK3R1	27
KEGG	hsa04744	Phototransduction	8/1523	29/8135	0.1606	0.3831	0.3139	CALML3/CALM3/CALML5/CNGA1/GNB1/GRK1/GNAT2/PDE6B	8
KEGG	hsa00360	Phenylalanine metabolism	5/1523	16/8135	0.1648	0.3904	0.3199	ALDH3B2/ALDH3A1/HPD/GOT2/GOT1	5
KEGG	hsa04060	Cytokine-cytokine receptor interaction	62/1523	295/8135	0.1698	0.3993	0.3272	CXCL5/IL1F10/TGFBR2/CXCL17/IL22RA1/CCL27/IL20RB/EBI3/BMP7/IL20RA/CXCL14/CCR5/GH2/TNFSF12/IL10RA/IL6ST/IL17RE/CSF1/EPOR/CD4/IL23R/TNFRSF1B/IL22/CD40/IL20/IL27RA/CCL4/BMP6/CCL21/TNFSF13/CCL22/TNFRSF19/CCL19/TNFSF13B/CSF2RB/CCR2/IL15/TNFSF11/CXCL3/IL10/IFNAR2/TNFRSF10D/BMP8B/CCR1/IL17A/ACVR1/CSF1R/IL17RB/CSH1/CSF3R/IL7/IL3RA/TNFRSF13B/TNFRSF11B/IL11/CXCL6/TSLP/TNFSF8/BMP2/IL13RA2/CCR10/CSH2	62
KEGG	hsa04720	Long-term potentiation	16/1523	67/8135	0.1748	0.4084	0.3346	CALML3/CALM3/CALML5/HRAS/RPS6KA6/MAP2K1/ITPR2/RAP1B/PRKCA/PPP3R1/ADCY1/RAF1/GNAQ/ADCY8/PLCB2/GRIN2A	16
KEGG	hsa05223	Non-small cell lung cancer	17/1523	72/8135	0.1781	0.4132	0.3386	HRAS/TGFA/MAP2K1/AKT1/PIK3R2/PIK3R3/PRKCA/AKT3/E2F3/RAF1/BAX/HGF/GRB2/STAT5A/PIK3R1/CDKN2A/RET	17
KEGG	hsa00240	Pyrimidine metabolism	14/1523	58/8135	0.184	0.4223	0.346	HDDC2/ENTPD3/ENTPD6/NT5M/NME4/UMPS/TK2/CTPS2/ASMTL/CANT1/CDA/UPP1/TYMS/ENTPD1	14
KEGG	hsa04218	Cellular senescence	34/1523	156/8135	0.1855	0.4223	0.346	CALML3/CALM3/CALML5/HRAS/TGFBR2/RAD50/MAPK12/HLA-B/HLA-G/SLC25A5/MAP2K1/CCNB1/AKT1/ITPR2/PIK3R2/HIPK2/CAPN1/MTOR/CCNE2/MAPK13/HLA-F/PIK3R3/SERPINE1/PPP3R1/HLA-C/CAPN2/AKT3/E2F3/RAF1/PPID/CACNA1D/CCNA1/PIK3R1/CDKN2A	34
KEGG	hsa04141	Protein processing in endoplasmic reticulum	37/1523	171/8135	0.1859	0.4223	0.346	UBQLN4/HSPA4L/HSP90AA1/MAN1A1/VCP/UBE4B/SSR2/DERL3/DNAJA2/RRBP1/EDEM2/UBE2G1/PRKCSH/CAPN1/MAN1B1/LMAN1L/BAG1/PDIA4/CAPN2/STT3B/LMAN1/SAR1A/DNAJB2/SEC23A/SEL1L/BAX/TRAM1L1/GANAB/FBXO2/YOD1/BAG2/CANX/DERL1/SEC61A1/HSPH1/LMAN2/SIL1	37
KEGG	hsa04713	Circadian entrainment	22/1523	97/8135	0.1891	0.4267	0.3496	CALML3/CALM3/CALML5/NOS1/GNB3/GNAI2/RYR1/GNAI1/GNB1/KCNJ6/PRKCA/GNG2/ADCY1/RYR3/GNAQ/GNG10/ADCY8/CACNA1D/GNG4/PLCB2/GRIN2A/ADCYAP1	22
KEGG	hsa05145	Toxoplasmosis	25/1523	112/8135	0.1926	0.4294	0.3518	HLA-DMA/LAMB4/HLA-DRB1/LAMC2/CCR5/IL10RA/MAPK12/GNAI2/HLA-DRA/LY96/HLA-DMB/GNAI1/CD40/PIK3R5/AKT1/LAMA3/MAPK13/HLA-DRB4/TLR4/PIK3CG/AKT3/IL10/TLR2/HLA-DPA1/MAP3K7	25
KEGG	hsa00562	Inositol phosphate metabolism	17/1523	73/8135	0.1941	0.4294	0.3518	IPPK/PIK3C2G/PIP5K1A/PIP5K1C/PIP4K2A/PIK3CG/ITPKC/IMPA2/MINPP1/PIP4K2C/IMPA1/INPP5J/INPPL1/INPP5F/ITPK1/PLCB2/MTMR4	17
KEGG	hsa01524	Platinum drug resistance	17/1523	73/8135	0.1941	0.4294	0.3518	GSTT1/GSTO2/ATP7A/GSTA3/MSH3/AKT1/PIK3R2/PIK3R3/AKT3/MSH2/GSTA4/BAX/GSTM3/PIK3R1/BID/CDKN2A/TOP2B	17
KEGG	hsa04612	Antigen processing and presentation	18/1523	78/8135	0.1966	0.4319	0.3539	HSP90AA1/HLA-DMA/HLA-DRB1/CD74/TAPBP/CD4/HLA-B/HLA-DRA/HLA-G/HLA-DMB/CTSS/RFX5/HLA-DRB4/HLA-F/IFI30/HLA-C/HLA-DPA1/CANX	18
KEGG	hsa00120	Primary bile acid biosynthesis	5/1523	17/8135	0.1996	0.4346	0.3561	CYP39A1/CYP7B1/CYP46A1/AMACR/HSD17B4	5
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1523	26/8135	0.2004	0.4346	0.3561	GPLD1/PIGT/PIGL/PIGB/PIGN/PIGP/PIGY	7
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1523	143/8135	0.2078	0.4478	0.3669	WNT16/ISL1/HRAS/FGFR3/DLX5/FGFR2/WNT3/WNT4/FZD8/MAPK12/IL6ST/WNT1/MAP2K1/WNT5B/AKT1/HOXA1/PIK3R2/MAPK13/WNT10A/PIK3R3/AKT3/LEFTY2/FZD6/RAF1/ACVR1/RIF1/WNT2B/GRB2/WNT5A/ID4/PIK3R1	31
KEGG	hsa00410	beta-Alanine metabolism	8/1523	31/8135	0.2114	0.4525	0.3708	ALDH3B2/ALDH3A1/ACADS/ACOX3/HIBCH/EHHADH/ALDH7A1/ALDH3A2	8
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1523	89/8135	0.2157	0.459	0.3761	HRAS/CSNK2A2/BATF/MAPK12/CD4/MAP2K1/AKT1/PIK3R2/MTOR/MAPK13/TLR4/PIK3R3/PPP3R1/MAP3K3/AKT3/RAF1/TLR2/PIK3R1/BATF2/PTPN6	20
KEGG	hsa04625	C-type lectin receptor signaling pathway	23/1523	104/8135	0.2185	0.4619	0.3785	CALML3/CALM3/CALML5/HRAS/FCER1G/MAPK12/AKT1/ITPR2/PIK3R2/CLEC4E/MAPK13/CCL22/PIK3R3/PPP3R1/LSP1/AKT3/IL10/CLEC4D/RAF1/RHOA/PIK3R1/BCL3/NLRP3	23
KEGG	hsa05321	Inflammatory bowel disease	15/1523	65/8135	0.224	0.4704	0.3855	HLA-DMA/HLA-DRB1/IL23R/HLA-DRA/IL22/HLA-DMB/HLA-DRB4/TLR4/RORC/IL10/IL17A/TLR2/RORA/HLA-DPA1/GATA3	15
KEGG	hsa04613	Neutrophil extracellular trap formation	40/1523	190/8135	0.2273	0.4738	0.3882	ITGAM/C5AR1/NCF4/ITGB3/FCGR2A/ITGB2/MAPK12/TLR7/SELPLG/SLC25A5/HDAC3/FCGR1A/MAP2K1/AKT1/HDAC8/CYBB/CYBA/PIK3R2/MTOR/MAPK13/TLR4/PIK3R3/PRKCA/AKT3/CLCN3/HDAC11/RAF1/FPR1/GSDMD/SIGLEC9/TLR2/TLR8/RAC2/CR1/MPO/HDAC2/PLCB2/PIK3R1/FPR2/MAP3K7	40
KEGG	hsa00062	Fatty acid elongation	7/1523	27/8135	0.2298	0.4738	0.3882	ELOVL4/ELOVL1/ELOVL7/PPT2/MECR/ELOVL6/ACAA2	7
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	7/1523	27/8135	0.2298	0.4738	0.3882	ELOVL4/ACOX3/ELOVL1/ELOVL7/ELOVL6/HSD17B4/SCD	7
KEGG	hsa04152	AMPK signaling pathway	26/1523	120/8135	0.2336	0.4787	0.3923	PPP2R2C/ACACA/CFTR/HMGCR/CREB3L2/G6PC3/PPP2R3A/FBP1/RAB11B/AKT1/PIK3R2/MTOR/TBC1D1/PIK3R3/AKT3/PRKAA1/ADRA1A/PPP2R2A/PPARGC1A/ADIPOQ/EEF2K/SCD/CCNA1/PIK3R1/CRTC2/MAP3K7	26
KEGG	hsa00270	Cysteine and methionine metabolism	12/1523	51/8135	0.2352	0.4789	0.3924	BCAT1/PSAT1/SDSL/DNMT3B/PHGDH/MAT2A/GOT2/GOT1/AMD1/DNMT3A/CBS/LDHA	12
KEGG	hsa00061	Fatty acid biosynthesis	5/1523	18/8135	0.2366	0.4789	0.3924	ACACA/ACSBG1/OLAH/ACSL5/MECR	5
KEGG	hsa00140	Steroid hormone biosynthesis	14/1523	61/8135	0.241	0.482	0.3949	UGT1A6/SULT2B1/SULT1E1/HSD17B2/CYP2E1/HSD17B6/CYP3A5/CYP3A7/CYP7B1/CYP11A1/DHRS11/HSD17B7/CYP3A4/HSD3B1	14
KEGG	hsa00561	Glycerolipid metabolism	14/1523	61/8135	0.241	0.482	0.3949	PNLIPRP3/AKR1B10/PNPLA3/AGPAT4/AKR1B1/MBOAT2/DGAT2/MBOAT1/LPIN2/LIPF/LIPG/ALDH7A1/AGPAT2/ALDH3A2	14
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	44/1523	212/8135	0.2454	0.4834	0.3961	UGT1A6/GSTT1/HRAS/GSTO2/EPHX3/CHRNA3/MIRLET7D/GSTA3/HSP90AA1/KLF5/CHRNA9/CREB3L2/DLL3/AIP/GNAI2/RPS6KA6/WNT1/ARRB2/FGF16/GNAI1/MAP2K1/FGF18/AKT1/KPNA2/DLL1/PIK3R2/MTOR/PIK3R3/PRKCA/TNFSF11/ADCY1/AKT3/RAF1/KPNA3/GSTA4/GRB2/PAQR7/ADCY8/CACNA1D/CYP3A4/GSTM3/STAT5A/PIK3R1/ESR1	44
KEGG	hsa01250	Biosynthesis of nucleotide sugars	9/1523	37/8135	0.2455	0.4834	0.3961	TSTA3/GPI/GMPPA/GMDS/PGM2/CMAS/HK3/PMM2/UAP1L1	9
KEGG	hsa05210	Colorectal cancer	19/1523	86/8135	0.2475	0.4834	0.3961	HRAS/TGFBR2/TGFA/MSH3/MAP2K1/AKT1/PIK3R2/MTOR/APPL1/PIK3R3/AKT3/MSH2/BCL2L11/RAF1/BAX/RAC2/RHOA/GRB2/PIK3R1	19
KEGG	hsa05169	Epstein-Barr virus infection	42/1523	202/8135	0.2475	0.4834	0.3961	ENTPD3/HLA-DMA/HLA-DRB1/RBPJL/RBPJ/MAPK12/TAPBP/HLA-B/PSMD11/HLA-DRA/HLA-G/MAP2K4/NEDD4/HLA-DMB/CD40/AKT1/PIK3R2/CCNE2/MAPK13/HLA-DRB4/SAP30/HLA-F/PIK3R3/PSMC6/HLA-C/AKT3/BCL2L11/E2F3/CIR1/IFNAR2/TLR2/BAX/ISG15/HES1/HLA-DPA1/PSMD2/HDAC2/CCNA1/PIK3R1/BID/ENTPD1/MAP3K7	42
KEGG	hsa04910	Insulin signaling pathway	29/1523	137/8135	0.2601	0.5016	0.411	ACACA/PRKCI/CALML3/CALM3/CALML5/HRAS/G6PC3/FLOT1/RAPGEF1/FBP1/PTPRF/MKNK1/SHC4/MAP2K1/AKT1/PIK3R2/MTOR/PHKA1/PIK3R3/PRKCZ/AKT3/PRKAA1/RAF1/PYGM/HK3/GRB2/PPARGC1A/INPPL1/PIK3R1	29
KEGG	hsa00010	Glycolysis / Gluconeogenesis	15/1523	67/8135	0.2627	0.5016	0.411	ALDH3B2/ALDH3A1/G6PC3/GPI/ADH7/FBP1/ADH1B/PGM2/MINPP1/HK3/ALDH7A1/ALDH3A2/ALDOB/LDHA/PDHA1	15
KEGG	hsa00982	Drug metabolism - cytochrome P450	16/1523	72/8135	0.2636	0.5016	0.411	ALDH3B2/UGT1A6/GSTT1/ALDH3A1/GSTO2/CYP2E1/GSTA3/CYP3A5/ADH7/CYP2C9/FMO1/ADH1B/FMO2/GSTA4/CYP3A4/GSTM3	16
KEGG	hsa05218	Melanoma	16/1523	72/8135	0.2636	0.5016	0.411	CDH1/HRAS/FGF16/MAP2K1/FGF18/AKT1/PIK3R2/PIK3R3/AKT3/E2F3/RAF1/PDGFB/BAX/HGF/PIK3R1/CDKN2A	16
KEGG	hsa04914	Progesterone-mediated oocyte maturation	22/1523	102/8135	0.2643	0.5016	0.411	HSP90AA1/MAPK12/GNAI2/CDC26/RPS6KA6/GNAI1/MAP2K1/CCNB1/AKT1/PIK3R2/MAPK13/PIK3R3/ADCY1/AKT3/ANAPC7/ANAPC1/RAF1/ADCY8/CCNA1/PIK3R1/MAD1L1/CDC16	22
KEGG	hsa00531	Glycosaminoglycan degradation	5/1523	19/8135	0.2753	0.5194	0.4256	SGSH/NAGLU/HYAL4/GUSB/HYAL1	5
KEGG	hsa04659	Th17 cell differentiation	23/1523	108/8135	0.2799	0.5207	0.4267	TGFBR2/EBI3/HSP90AA1/HLA-DMA/HLA-DRB1/MAPK12/IL6ST/CD4/IL23R/HLA-DRA/IL22/HLA-DMB/IL27RA/MTOR/MAPK13/HLA-DRB4/PPP3R1/RORC/IL17A/RORA/HLA-DPA1/GATA3/STAT5A	23
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1523	53/8135	0.2803	0.5207	0.4267	ATP1A1/KLK1/CLTB/FXYD2/RAB11A/AP2A2/PRKCA/ATP1B1/GNAQ/AP2M1/PLCB2/ESR1	12
KEGG	hsa04974	Protein digestion and absorption	22/1523	103/8135	0.2806	0.5207	0.4267	ATP1A1/SLC15A1/PRSS3/ACE2/COL4A5/COL17A1/COL7A1/PRSS2/FXYD2/SLC16A10/COL28A1/KCNJ13/SLC7A7/SLC38A2/COL4A6/COL6A1/ATP1B1/CELA2B/SLC9A3/CELA2A/KCNQ1/COL6A6	22
KEGG	hsa05217	Basal cell carcinoma	14/1523	63/8135	0.2824	0.5211	0.427	WNT16/WNT3/WNT4/FZD8/KIF7/WNT1/WNT5B/GLI2/WNT10A/FZD6/BAX/WNT2B/WNT5A/BMP2	14
KEGG	hsa05131	Shigellosis	50/1523	247/8135	0.2908	0.5335	0.4372	PRKCE/RRAGC/ACTR3B/CAPNS1/ELMO1/MAPK12/PIK3R4/HCLS1/ARPC1B/ACTR3C/ROCK1/TLN1/PXN/AKT1/ARPC5/ITPR2/PIK3R2/CAPN1/MTOR/MAPK13/U2AF1L4/ITGA5/PFN1/TLR4/PIK3R3/ARHGEF2/NLRC4/CAPN2/AKT3/ARPC5L/RBCK1/BAX/PPID/MAP1LC3A/RHOA/HK3/MYL2/ATG12/ELMO2/RPS27A/VCL/PLCB2/ACTN1/CD14/GLMN/PIK3R1/UBE2NL/ARPC4/MAP3K7/NLRP3	50
KEGG	hsa04392	Hippo signaling pathway - multiple species	7/1523	29/8135	0.2923	0.5335	0.4372	WWC1/TEAD3/LIMD1/RASSF6/SAV1/RASSF2/TEAD4	7
KEGG	hsa04620	Toll-like receptor signaling pathway	22/1523	104/8135	0.2973	0.5397	0.4422	MAPK12/TLR7/CD86/LY96/MAP2K4/CD40/CCL4/MAP2K1/AKT1/PIK3R2/TLR1/MAPK13/TLR4/PIK3R3/AKT3/IFNAR2/TLR2/TLR8/CD14/SPP1/PIK3R1/MAP3K7	22
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	15/1523	69/8135	0.3036	0.5464	0.4477	UGT1A6/GSTT1/GSTO2/CYP2C18/CYP2E1/GSTA3/CYP3A5/CYP3A7/CYP2C9/SULT1A2/SULT1A1/GSTA4/CBR1/CYP3A4/GSTM3	15
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1523	15/8135	0.3043	0.5464	0.4477	FUT2/ST3GAL1/ST3GAL2/FUT1	4
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1523	20/8135	0.3151	0.5612	0.4599	CHST14/CHST11/CSGALNACT1/B4GALT7/CSGALNACT2	5
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1523	100/8135	0.3159	0.5612	0.4599	HRAS/TGFBR2/PRKCE/COL4A5/MAPK12/AKT1/CYBB/COL4A6/PIK3R2/MAPK13/PIK3R3/SERPINE1/PRKCA/PRKCZ/AKT3/SELE/NOS3/BAX/PLCB2/STAT5A/PIK3R1	21
KEGG	hsa00983	Drug metabolism - other enzymes	17/1523	80/8135	0.322	0.5681	0.4655	UGT1A6/GSTT1/GSTO2/CYP2E1/GSTA3/XDH/GUSB/NME4/UMPS/TK2/GMPS/GSTA4/CDA/UPP1/MPO/CYP3A4/GSTM3	17
KEGG	hsa01523	Antifolate resistance	7/1523	30/8135	0.3249	0.5681	0.4655	ALOX12/GGH/SLC46A1/SHMT1/FPGS/TYMS/GART	7
KEGG	hsa04978	Mineral absorption	13/1523	60/8135	0.3269	0.5681	0.4655	ATP1A1/SLC5A1/ATP7A/TRPV6/SLC26A9/FTL/FXYD2/SLC46A1/SLC34A2/FTH1/ATP1B1/SLC9A3/TF	13
KEGG	hsa00510	N-Glycan biosynthesis	11/1523	50/8135	0.3282	0.5681	0.4655	ALG5/MAN1A1/MGAT1/ALG6/MAN1B1/STT3B/MGAT5/MGAT5B/GANAB/MAN2A1/ALG3	11
KEGG	hsa04020	Calcium signaling pathway	48/1523	240/8135	0.3283	0.5681	0.4655	ERBB3/CALML3/CALM3/CALML5/FGFR3/FGFR2/P2RX4/MST1R/ORAI3/NOS1/SPHK2/GNAL/NTRK1/CD38/RYR1/HTR2A/SLC25A5/FGF16/FGF18/ITPR2/PHKA1/MYLK4/PRKCA/PPP3R1/AVPR1A/ITPKC/CYSLTR1/ADCY1/MST1/FLT4/P2RX2/ADRA1A/RYR3/CASQ1/PDGFB/NOS3/GNAQ/HGF/HTR7/TACR3/ADCY8/CACNA1D/GDNF/HTR6/PLCB2/GRIN2A/CHRM2/RET	48
KEGG	hsa04936	Alcoholic liver disease	29/1523	142/8135	0.3323	0.5721	0.4688	C1QB/C1QA/ACACA/C3AR1/CYP2E1/C5AR1/ADH7/C2/MAPK12/LY96/MAP2K4/ACOX3/AKT1/C1QC/MAPK13/TLR4/ADH1B/CXCL3/AKT3/PRKAA1/IL17A/LPIN2/PPARGC1A/ADIPOQ/ALDH7A1/SCD/ALDH3A2/CD14/MAP3K7	29
KEGG	hsa05032	Morphine addiction	19/1523	91/8135	0.3378	0.5786	0.4741	GABRP/GNB3/GABRR2/GNAI2/ARRB2/GNAI1/GNB1/KCNJ6/PRKCA/GNG2/ADCY1/GRK5/PDE4A/GNG10/GABRR1/ADCY8/GNG4/GABRB2/GABRE	19
KEGG	hsa05212	Pancreatic cancer	16/1523	76/8135	0.3441	0.5834	0.478	TGFBR2/TGFA/ARHGEF6/RALBP1/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/AKT3/E2F3/RAF1/BAX/RAC2/PIK3R1/CDKN2A	16
KEGG	hsa05220	Chronic myeloid leukemia	16/1523	76/8135	0.3441	0.5834	0.478	HRAS/TGFBR2/SHC4/MAP2K1/AKT1/PIK3R2/PIK3R3/AKT3/E2F3/RAF1/BAX/GRB2/HDAC2/STAT5A/PIK3R1/CDKN2A	16
KEGG	hsa05017	Spinocerebellar ataxia	29/1523	143/8135	0.3474	0.5861	0.4802	SLC1A6/RBPJL/SPTBN2/RBPJ/PIK3R4/PSMD11/VLDLR/PSMB7/RYR1/SLC25A5/AFG3L2/RELN/AKT1/ITPR2/PIK3R2/MTOR/KCND3/PIK3R3/PRKCA/PSMC6/AKT3/GNAQ/PSMB2/FGF14/RORA/PSMD2/PLCB2/GRIN2A/PIK3R1	29
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/1523	16/8135	0.3508	0.5862	0.4803	GGT6/FMO1/FMO2/GGT1	4
KEGG	hsa05215	Prostate cancer	20/1523	97/8135	0.3542	0.5862	0.4803	HRAS/TMPRSS2/FGFR2/HSP90AA1/TGFA/CREB3L2/MAP2K1/AKT1/PIK3R2/MTOR/CCNE2/PIK3R3/AKT3/E2F3/RAF1/PDGFB/GRB2/MMP3/SPINT1/PIK3R1	20
KEGG	hsa04216	Ferroptosis	9/1523	41/8135	0.3567	0.5862	0.4803	FTL/ACSL5/FTH1/CYBB/GPX4/SAT2/MAP1LC3A/TF/PCBP1	9
KEGG	hsa00790	Folate biosynthesis	6/1523	26/8135	0.3575	0.5862	0.4803	AKR1B10/AKR1B1/GGH/PCBD2/FPGS/CBR1	6
KEGG	hsa00500	Starch and sucrose metabolism	8/1523	36/8135	0.3576	0.5862	0.4803	G6PC3/GPI/GYG1/MGAM/PGM2/PYGM/HK3/GAA	8
KEGG	hsa00052	Galactose metabolism	7/1523	31/8135	0.358	0.5862	0.4803	AKR1B10/AKR1B1/G6PC3/MGAM/PGM2/HK3/GAA	7
KEGG	hsa04146	Peroxisome	17/1523	82/8135	0.3623	0.5902	0.4836	ABCD3/ACSL5/XDH/SLC25A17/PXMP4/PEX7/ACOX3/PMVK/NUDT12/CROT/DDO/AMACR/PEX3/CRAT/EHHADH/HSD17B4/MPV17	17
KEGG	hsa03013	Nucleocytoplasmic transport	22/1523	108/8135	0.3667	0.5946	0.4872	NXF3/IPO7/NUP54/NUP155/IPO5/XPO5/NUP205/KPNA2/XPOT/UPF3B/IPO4/TNPO3/TNPO1/SUMO3/SENP2/CSE1L/KPNA3/NUP35/SAP18/IPO13/UPF1/NUP188	22
KEGG	hsa04934	Cushing syndrome	31/1523	155/8135	0.3719	0.5959	0.4883	WNT16/WNT3/CREB3L2/WNT4/STAR/AIP/FZD8/GNAI2/WNT1/GNAI1/MAP2K1/WNT5B/CYP11A1/ITPR2/CCNE2/WNT10A/RAP1B/KCNK3/ADCY1/FZD6/E2F3/NCEH1/CRHR1/GNAQ/WNT2B/WNT5A/ADCY8/CACNA1D/PLCB2/CDKN2A/HSD3B1	31
KEGG	hsa00564	Glycerophospholipid metabolism	20/1523	98/8135	0.3729	0.5959	0.4883	PLA2G4F/CDS1/PLA2G3/AGPAT4/PLA2G4D/PLD3/PGS1/PLA2G4C/MBOAT2/LPGAT1/CDS2/PLA2G15/LPCAT1/MBOAT1/PLA2G2D/LPIN2/PLA2G12A/PLA2G1B/AGPAT2/PCYT1A	20
KEGG	hsa04925	Aldosterone synthesis and secretion	20/1523	98/8135	0.3729	0.5959	0.4883	ATP1A1/CALML3/CALM3/CALML5/PRKCE/CREB3L2/STAR/NPPA/CYP11A1/ITPR2/KCNK3/PRKCA/ADCY1/ATP1B1/GNAQ/NPR1/ADCY8/CACNA1D/PLCB2/HSD3B1	20
KEGG	hsa00620	Pyruvate metabolism	10/1523	47/8135	0.3826	0.6056	0.4962	ACAT2/ACACA/ADH7/GLO1/ADH1B/ME3/ALDH7A1/ALDH3A2/LDHA/PDHA1	10
KEGG	hsa04066	HIF-1 signaling pathway	22/1523	109/8135	0.3846	0.6056	0.4962	SLC2A1/NPPA/TIMP1/MKNK1/MAP2K1/AKT1/EGLN3/CYBB/PIK3R2/MTOR/TLR4/PIK3R3/SERPINE1/PRKCA/AKT3/NOS3/HK3/TF/ALDOB/PIK3R1/LDHA/PDHA1	22
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	16/1523	78/8135	0.3862	0.6056	0.4962	ALDH3B2/UGT1A6/GSTT1/ALDH3A1/GSTO2/CYP2E1/GSTA3/CYP3A5/ADH7/CYP2C9/ADH1B/AKR7A3/GSTA4/CBR1/CYP3A4/GSTM3	16
KEGG	hsa04721	Synaptic vesicle cycle	16/1523	78/8135	0.3862	0.6056	0.4962	ATP6V1C2/SLC6A11/SLC1A6/ATP6V0A4/CLTB/RAB3A/SLC6A2/ATP6V0E1/SLC6A13/AP2A2/ATP6V1E1/STX2/TCIRG1/ATP6V1G3/AP2M1/SLC18A1	16
KEGG	hsa00340	Histidine metabolism	5/1523	22/8135	0.3962	0.6183	0.5067	ALDH3B2/ALDH3A1/HAL/ALDH7A1/ALDH3A2	5
KEGG	hsa05417	Lipid and atherosclerosis	42/1523	215/8135	0.406	0.6307	0.5168	POU2F3/CALML3/CALM3/CALML5/HRAS/VAV3/CYP2J2/HSP90AA1/NCF4/MAPK12/CYP2C9/VLDLR/LY96/MAP2K4/OLR1/CD40/AKT1/CYBB/CYBA/PIK3R2/MAPK13/RAP1B/APOA1/TLR4/PIK3R3/PRKCA/PPP3R1/CXCL3/AKT3/SELE/VAV1/NOS3/TLR2/BAX/RHOA/MMP3/PLCB2/CD14/PIK3R1/BID/MAP3K7/NLRP3	42
KEGG	hsa04919	Thyroid hormone signaling pathway	24/1523	121/8135	0.4123	0.6376	0.5224	ATP1A1/HRAS/SLC2A1/WNT4/FXYD2/ITGB3/SLC16A10/HDAC3/MAP2K1/AKT1/DIO2/PIK3R2/MTOR/PIK3R3/PRKCA/AKT3/ATP1B1/RAF1/MED12L/HDAC2/PLCB2/MED16/PIK3R1/ESR1	24
KEGG	hsa04080	Neuroactive ligand-receptor interaction	68/1523	353/8135	0.4169	0.6417	0.5258	LYPD6B/NMU/ADORA3/PRSS3/C3AR1/SLURP1/F2RL1/F2RL2/CHRNA3/GABRP/P2RX4/CHRNA9/PRSS2/C5AR1/VIPR1/GH2/GABRR2/LTB4R/AVPR2/HTR2A/LPAR3/P2RY6/F2/PTGER2/P2RY1/GALR3/KNG1/LPAR6/TAC1/NPB/RLN3/AVPR1A/DRD2/UCN2/CYSLTR1/GLRA2/EDN3/FPR1/NPY1R/P2RX2/NPY/ADRA1A/RXFP3/CRHR1/NMUR1/CSH1/CHRNA5/LHB/HTR7/GABRR1/TACR3/GHRL/HTR6/GLRA1/GABRB2/GRIN2A/SST/GHSR/GABRE/GRP/UCN/ADCYAP1/FPR2/PARD3/P2RY8/CHRM2/HCRTR1/CSH2	68
KEGG	hsa01240	Biosynthesis of cofactors	30/1523	153/8135	0.421	0.645	0.5285	UGT1A6/MMAB/RDH12/SDR16C5/HSD17B6/NMNAT3/AK7/RDH13/GGH/BCAT1/SHMT1/PSAT1/HPD/PANK1/GMPPA/MAT2A/COX10/GUSB/NME4/UROD/UMPS/FPGS/CTPS2/PANK2/EARS2/PANK3/COQ3/TPK1/PMM2/ALDH3A2	30
KEGG	hsa03320	PPAR signaling pathway	15/1523	75/8135	0.4339	0.6598	0.5406	HMGCS1/FABP7/ACSBG1/HMGCS2/ACSL5/SLC27A6/DBI/OLR1/ACOX3/SLC27A4/APOA1/ME3/EHHADH/ADIPOQ/SCD	15
KEGG	hsa03430	Mismatch repair	5/1523	23/8135	0.4366	0.6598	0.5406	RFC5/MSH3/POLD2/MSH2/POLD4	5
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	5/1523	23/8135	0.4366	0.6598	0.5406	ATP1A1/FXYD2/CA2/ATP1B1/SLC9A3	5
KEGG	hsa04668	TNF signaling pathway	22/1523	112/8135	0.4388	0.6602	0.5409	CXCL5/CREB3L2/MAPK12/CSF1/MAP2K4/TNFRSF1B/MAP2K1/AKT1/PIK3R2/MAPK13/PIK3R3/IL15/CXCL3/AKT3/SELE/CXCL6/MLKL/DAB2IP/MMP3/PIK3R1/BCL3/MAP3K7	22
KEGG	hsa00230	Purine metabolism	25/1523	128/8135	0.4423	0.6615	0.5421	ADK/GDA/HDDC2/PAPSS2/AK7/ENTPD3/XDH/DGUOK/ENTPD6/ENPP4/NT5M/NME4/ADCY1/NUDT16/PGM2/GMPS/NPR1/PDE4A/CANT1/ADCY8/PDE6B/PAICS/GMPR2/ENTPD1/GART	25
KEGG	hsa04922	Glucagon signaling pathway	21/1523	107/8135	0.4436	0.6615	0.5421	ACACA/CALML3/CALM3/CALML5/SLC2A1/CREB3L2/G6PC3/FBP1/AKT1/ITPR2/PHKA1/PPP3R1/AKT3/PRKAA1/PYGM/GNAQ/PPARGC1A/PLCB2/LDHA/PDHA1/CRTC2	21
KEGG	hsa03450	Non-homologous end-joining	3/1523	13/8135	0.4506	0.6689	0.5481	RAD50/POLL/PRKDC	3
KEGG	hsa05164	Influenza A	33/1523	171/8135	0.4539	0.6707	0.5496	PRSS3/NXF3/TMPRSS2/TMPRSS4/HLA-DMA/PRSS2/HLA-DRB1/TMPRSS11D/TLR7/HLA-DRA/SLC25A5/RAB11B/HLA-DMB/RAB11A/MAP2K1/AKT1/KPNA2/PIK3R2/FDPS/HLA-DRB4/TLR4/PIK3R3/PRKCA/AKT3/IFNAR2/RAF1/BAX/HLA-DPA1/NLRX1/HNRNPUL1/PIK3R1/BID/NLRP3	33
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1523	77/8135	0.4781	0.7034	0.5764	DSP/JUP/ITGA2/ITGB6/ITGB3/ITGA11/DSG2/ITGA5/ITGA3/CACNB4/CACNG3/CACNG2/CACNB3/CACNA1D/CACNA2D4	15
KEGG	hsa00260	Glycine, serine and threonine metabolism	8/1523	40/8135	0.4811	0.7048	0.5775	GATM/SHMT1/PSAT1/SDSL/PHGDH/SRR/ALDH7A1/CBS	8
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1523	19/8135	0.488	0.7118	0.5833	GPT2/BCAT1/GOT2/GOT1	4
KEGG	hsa01200	Carbon metabolism	22/1523	115/8135	0.4931	0.716	0.5867	ACAT2/ACADS/GPT2/GPI/SHMT1/PSAT1/FBP1/SDSL/ACOX3/PHGDH/HIBCH/GOT2/GOT1/PCCA/MCEE/SDHA/ME3/SDHB/HK3/ALDOB/PDHA1/SUCLG1	22
KEGG	hsa04930	Type II diabetes mellitus	9/1523	46/8135	0.5011	0.7245	0.5936	PRKCE/PIK3R2/MTOR/PIK3R3/PRKCZ/HK3/ADIPOQ/CACNA1D/PIK3R1	9
KEGG	hsa05134	Legionellosis	11/1523	57/8135	0.5091	0.7329	0.6006	ITGAM/VCP/ITGB2/TLR4/NLRC4/CXCL3/SAR1A/TLR2/CR1/SEC22B/CD14	11
KEGG	hsa03030	DNA replication	7/1523	36/8135	0.5229	0.7496	0.6142	RFC5/RNASEH2C/MCM4/POLD2/RNASEH2A/POLD4/DNA2	7
KEGG	hsa00670	One carbon pool by folate	4/1523	20/8135	0.5313	0.7583	0.6214	SHMT1/MTHFS/TYMS/GART	4
KEGG	hsa05213	Endometrial cancer	11/1523	58/8135	0.5343	0.7592	0.6221	CDH1/HRAS/MAP2K1/AKT1/PIK3R2/PIK3R3/AKT3/RAF1/BAX/GRB2/PIK3R1	11
KEGG	hsa04710	Circadian rhythm	6/1523	31/8135	0.5364	0.7592	0.6221	BHLHE41/NPAS2/CLOCK/RORC/PRKAA1/RORA	6
KEGG	hsa05202	Transcriptional misregulation in cancer	36/1523	193/8135	0.5397	0.7606	0.6232	WNT16/LDB1/TGFBR2/TMPRSS2/MEF2C/JUP/ITGAM/SS18L1/HOXA11/NTRK1/CD86/HHEX/CD40/FCGR1A/TLX1/PROM1/CEBPE/FLI1/SIX4/CSF1R/SPI1/BAX/LMO2/ZBTB16/MMP3/LYL1/MPO/FLT3/HDAC2/ETV7/BCL2A1/CD14/CCNA1/SPINT1/ETV1/TAF15	36
KEGG	hsa01230	Biosynthesis of amino acids	14/1523	75/8135	0.552	0.7719	0.6325	GPT2/BCAT1/SHMT1/PSAT1/SDSL/PHGDH/MAT2A/ARG1/GOT2/GOT1/GLUL/ALDOB/CBS/PYCR2	14
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	7/1523	37/8135	0.5543	0.7719	0.6325	FOLH1/GPT2/GOT2/GOT1/NIT2/GLUL/DDO	7
KEGG	hsa04911	Insulin secretion	16/1523	86/8135	0.5552	0.7719	0.6325	ATP1A1/KCNN3/SLC2A1/CREB3L2/FXYD2/RAB3A/RAPGEF4/PRKCA/PCLO/ADCY1/ATP1B1/GNAQ/ADCY8/CACNA1D/PLCB2/ADCYAP1	16
KEGG	hsa04330	Notch signaling pathway	11/1523	59/8135	0.5591	0.7719	0.6325	APH1B/RBPJL/DLL3/RBPJ/DLL1/HES5/CIR1/HES1/HDAC2/JAG2/TLE6	11
KEGG	hsa04931	Insulin resistance	20/1523	108/8135	0.5611	0.7719	0.6325	PRKCE/SLC2A1/CREB3L2/G6PC3/SLC27A6/RPS6KA6/PTPRF/AKT1/PIK3R2/MTOR/SLC27A4/PIK3R3/PRKCZ/AKT3/PRKAA1/PYGM/NOS3/PPARGC1A/PIK3R1/CRTC2	20
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1523	70/8135	0.5616	0.7719	0.6325	ATP6V1C2/PTPRZ1/ATP6V0A4/MAPK12/ATP6V0E1/MAP2K4/F11R/ATP6V1E1/MAPK13/TCIRG1/CXCL3/ATP6V1G3/TJP1	13
KEGG	hsa04658	Th1 and Th2 cell differentiation	17/1523	92/8135	0.5666	0.7756	0.6355	HLA-DMA/HLA-DRB1/RBPJL/DLL3/RBPJ/MAPK12/CD4/HLA-DRA/HLA-DMB/DLL1/MAPK13/HLA-DRB4/PPP3R1/HLA-DPA1/JAG2/GATA3/STAT5A	17
KEGG	hsa04927	Cortisol synthesis and secretion	12/1523	65/8135	0.572	0.7798	0.639	CREB3L2/STAR/CYP11A1/ITPR2/KCNK3/ADCY1/NCEH1/GNAQ/ADCY8/CACNA1D/PLCB2/HSD3B1	12
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1523	27/8135	0.5885	0.7991	0.6548	FUT2/FUT4/FUT1/B3GNT2/FUT3	5
KEGG	hsa04130	SNARE interactions in vesicular transport	6/1523	33/8135	0.6021	0.8142	0.6671	STX8/STX19/VAMP5/STX2/VAMP1/SEC22B	6
KEGG	hsa04350	TGF-beta signaling pathway	17/1523	94/8135	0.6051	0.815	0.6678	TGFBR2/BMP7/THSD4/ROCK1/BMP6/RGMA/FST/LEFTY2/BMP8B/ACVR1/PITX2/RHOA/GREM1/ID4/BMP2/NEO1/THBS1	17
KEGG	hsa00513	Various types of N-glycan biosynthesis	7/1523	39/8135	0.614	0.8236	0.6749	MAN1A1/MGAT1/MAN1B1/STT3B/MAN2A1/ALG3/B4GALNT4	7
KEGG	hsa04115	p53 signaling pathway	13/1523	73/8135	0.6269	0.8367	0.6856	SFN/PERP/SERPINB5/TP53AIP1/SHISA5/EI24/CCNB1/CCNE2/SERPINE1/BAX/BID/CDKN2A/THBS1	13
KEGG	hsa04213	Longevity regulating pathway - multiple species	11/1523	62/8135	0.6299	0.8367	0.6856	HRAS/AKT1/PIK3R2/MTOR/PIK3R3/ADCY1/AKT3/PRKAA1/ADCY8/HDAC2/PIK3R1	11
KEGG	hsa03020	RNA polymerase	6/1523	34/8135	0.633	0.8367	0.6856	POLR3B/CD3EAP/POLR1B/POLR1C/POLR3GL/POLR2E	6
KEGG	hsa05410	Hypertrophic cardiomyopathy	16/1523	90/8135	0.6338	0.8367	0.6856	ACE/ITGA2/ITGB6/ITGB3/TNNT2/ITGA11/ITGA5/ITGA3/CACNB4/PRKAA1/CACNG3/CACNG2/MYL2/CACNB3/CACNA1D/CACNA2D4	16
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1523	11/8135	0.6388	0.84	0.6883	HPD/COQ3	2
KEGG	hsa03060	Protein export	4/1523	23/8135	0.6487	0.8464	0.6935	IMMP2L/SEC11A/SEC61A1/OXA1L	4
KEGG	hsa04614	Renin-angiotensin system	4/1523	23/8135	0.6487	0.8464	0.6935	ACE2/KLK1/ACE/REN	4
KEGG	hsa00310	Lysine degradation	11/1523	63/8135	0.6521	0.8475	0.6945	ACAT2/BBOX1/EZH2/SMYD2/PLOD1/SUV39H2/PLOD3/EHHADH/AASS/ALDH7A1/ALDH3A2	11
KEGG	hsa04920	Adipocytokine signaling pathway	12/1523	69/8135	0.6601	0.8545	0.7002	ACSBG1/SLC2A1/G6PC3/ACSL5/TNFRSF1B/AKT1/MTOR/AKT3/PRKAA1/NPY/PPARGC1A/ADIPOQ	12
KEGG	hsa03440	Homologous recombination	7/1523	41/8135	0.6692	0.8612	0.7057	RAD50/MUS81/POLD2/BARD1/POLD4/RAD52/BRIP1	7
KEGG	hsa05222	Small cell lung cancer	16/1523	92/8135	0.6704	0.8612	0.7057	COL4A5/LAMB4/ITGA2/LAMC2/AKT1/LAMA3/COL4A6/PIK3R2/CCNE2/ITGA3/PIK3R3/CKS1B/AKT3/E2F3/BAX/PIK3R1	16
KEGG	hsa00514	Other types of O-glycan biosynthesis	8/1523	47/8135	0.6758	0.8615	0.7059	GALNT2/GALNT3/GALNT10/GALNT14/GALNT11/GALNT7/PLOD3/POFUT2	8
KEGG	hsa03420	Nucleotide excision repair	8/1523	47/8135	0.6758	0.8615	0.7059	CDK7/RFC5/DDB1/POLD2/CUL4A/GTF2H3/ERCC6/POLD4	8
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1523	30/8135	0.6862	0.8695	0.7125	ACAT2/SHMT1/PCCA/GLUL/MCEE	5
KEGG	hsa05171	Coronavirus disease - COVID-19	41/1523	232/8135	0.6873	0.8695	0.7125	C1QB/C1QA/C3AR1/TMPRSS2/ACE2/ACE/RPS4Y1/C5AR1/RPLP1/C2/FCGR2A/MAPK12/IL6ST/TLR7/C9/RPS15A/F2/NRP1/CYBB/PIK3R2/F13A1/C1QC/MAPK13/TLR4/RPL31/PIK3R3/PRKCA/RPLP0/IFNAR2/RPS8/TLR2/TLR8/RPS18/ISG15/MMP3/RPS27A/RPS27L/PIK3R1/RPS7/MAP3K7/NLRP3	41
KEGG	hsa04657	IL-17 signaling pathway	16/1523	94/8135	0.7049	0.8885	0.728	CXCL5/S100A7/S100A7A/DEFB4A/HSP90AA1/MAPK12/IL17RE/MAPK13/MAPK4/CXCL3/IL17A/IL17RB/CXCL6/MMP3/MMP13/MAP3K7	16
KEGG	hsa04621	NOD-like receptor signaling pathway	32/1523	184/8135	0.7089	0.8901	0.7294	CARD18/DEFB4A/HSP90AA1/MFN1/MAPK12/ANTXR2/PKN1/CYBB/ITPR2/CYBA/PYDC1/MAPK13/TLR4/NLRC4/CXCL3/AIM2/IFNAR2/GSDMD/RBCK1/PSTPIP1/CARD16/MAP1LC3A/RHOA/ATG12/GBP5/NLRX1/DHX33/PLCB2/CARD8/NLRP6/MAP3K7/NLRP3	32
KEGG	hsa04211	Longevity regulating pathway	15/1523	89/8135	0.7163	0.8931	0.7318	HRAS/CREB3L2/AKT1/PIK3R2/MTOR/APPL1/PIK3R3/ADCY1/AKT3/PRKAA1/BAX/PPARGC1A/ADIPOQ/ADCY8/PIK3R1	15
KEGG	hsa05216	Thyroid cancer	6/1523	37/8135	0.7166	0.8931	0.7318	CDH1/HRAS/NTRK1/MAP2K1/BAX/RET	6
KEGG	hsa05030	Cocaine addiction	8/1523	49/8135	0.7223	0.8969	0.7349	CREB3L2/GNAI2/GNAI1/DRD2/DLG4/SLC18A1/GRIN2A/PPP1R1B	8
KEGG	hsa05414	Dilated cardiomyopathy	16/1523	96/8135	0.7372	0.912	0.7473	ITGA2/ITGB6/ITGB3/TNNT2/ITGA11/ITGA5/ITGA3/CACNB4/ADCY1/CACNG3/CACNG2/MYL2/CACNB3/ADCY8/CACNA1D/CACNA2D4	16
KEGG	hsa05203	Viral carcinogenesis	35/1523	204/8135	0.7457	0.9127	0.7479	POLB/HRAS/CREB3L2/RBPJL/CCR5/DDB1/RBPJ/IL6ST/HLA-B/HLA-G/SCRIB/HDAC3/PXN/HDAC8/YWHAZ/PIK3R2/CCNE2/HLA-F/PIK3R3/HPN/HLA-C/HDAC11/GTF2H3/BAX/RHOA/GRB2/DNAJA3/HDAC2/ACTN1/CCNA1/STAT5A/PIK3R1/CDKN2A/MAD1L1/YWHAB	35
KEGG	hsa04723	Retrograde endocannabinoid signaling	25/1523	148/8135	0.7487	0.9127	0.7479	GABRP/GNB3/GABRR2/MAPK12/GNAI2/GNAI1/GNB1/ITPR2/MAPK13/KCNJ6/PRKCA/GNG2/ADCY1/NDUFA1/GNAQ/GNG10/GABRR1/ADCY8/CACNA1D/NDUFA6/GNG4/PLCB2/GABRB2/GABRE/NAPEPLD	25
KEGG	hsa04068	FoxO signaling pathway	22/1523	131/8135	0.7488	0.9127	0.7479	HRAS/TGFBR2/HOMER2/G6PC3/MAPK12/NLK/MAP2K1/CCNB1/AKT1/PIK3R2/MAPK13/HOMER1/PIK3R3/AKT3/IL10/BCL2L11/PRKAA1/RAF1/GRB2/ATG12/SGK2/PIK3R1	22
KEGG	hsa04114	Oocyte meiosis	22/1523	131/8135	0.7488	0.9127	0.7479	CALML3/CALM3/CALML5/MAPK12/CDC26/RPS6KA6/MAP2K1/CCNB1/YWHAZ/ITPR2/CCNE2/MAPK13/PPP3R1/SLK/ADCY1/ANAPC7/ANAPC1/ADCY8/PTTG1/MAD1L1/CDC16/YWHAB	22
KEGG	hsa04110	Cell cycle	21/1523	126/8135	0.7578	0.9204	0.7542	SFN/CDK7/CDC26/MCM4/CCNB1/YWHAZ/CCNE2/TTK/ANAPC7/ANAPC1/E2F3/PRKDC/CDC7/HDAC2/CCNA1/PTTG1/STAG1/CDKN2A/MAD1L1/CDC16/YWHAB	21
KEGG	hsa03022	Basal transcription factors	7/1523	45/8135	0.7638	0.9243	0.7574	CDK7/TAF7L/TAF6/GTF2IRD1/GTF2H3/TAF8/TAF15	7
KEGG	hsa05031	Amphetamine addiction	11/1523	69/8135	0.7688	0.927	0.7596	CALML3/CALM3/CALML5/CREB3L2/PRKCA/PPP3R1/CACNA1D/HDAC2/SLC18A1/GRIN2A/PPP1R1B	11
KEGG	hsa05161	Hepatitis B	27/1523	162/8135	0.7796	0.9367	0.7675	HRAS/TGFBR2/CREB3L2/DDB1/MAPK12/MAP2K4/MAP2K1/AKT1/YWHAZ/PIK3R2/CCNE2/MAPK13/TLR4/PIK3R3/PRKCA/AKT3/E2F3/RAF1/TLR2/BAX/GRB2/CCNA1/STAT5A/PIK3R1/BID/YWHAB/MAP3K7	27
KEGG	hsa03050	Proteasome	7/1523	46/8135	0.784	0.9377	0.7683	PSMD11/PSMB7/PSMB10/PSMC6/PSMB9/PSMB2/PSMD2	7
KEGG	hsa05033	Nicotine addiction	6/1523	40/8135	0.7861	0.9377	0.7683	GABRP/GABRR2/GABRR1/GABRB2/GRIN2A/GABRE	6
KEGG	hsa00040	Pentose and glucuronate interconversions	5/1523	34/8135	0.79	0.939	0.7694	UGT1A6/AKR1B10/AKR1B1/SORD/GUSB	5
KEGG	hsa00730	Thiamine metabolism	2/1523	15/8135	0.8014	0.9459	0.7751	AK7/TPK1	2
KEGG	hsa05010	Alzheimer disease	66/1523	384/8135	0.8032	0.9459	0.7751	WNT16/IDE/SLC39A6/CALML3/CALM3/CALML5/HRAS/SLC39A2/APH1B/CSNK2A2/WNT3/MAPT/NOS1/WNT4/DKK2/FZD8/PIK3R4/CSF1/TUBA3C/PSMD11/TUBA4A/PSMB7/SLC25A5/WNT1/CSNK1A1/MAP2K1/WNT5B/AKT1/KLC3/CYBB/TUBB3/FRAT1/ITPR2/PIK3R2/CAPN1/MTOR/WNT10A/DKK1/PIK3R3/PPP3R1/PSMC6/CAPN2/AKT3/FZD6/TUBB2A/SLC39A5/RAF1/NDUFA1/TUBA8/RYR3/SDHA/GNAQ/SDHB/WNT2B/PSMB2/PPID/WNT5A/PSMD2/CACNA1D/NDUFA6/TUBAL3/PLCB2/UQCRB/GRIN2A/PIK3R1/BID	66
KEGG	hsa04976	Bile secretion	14/1523	89/8135	0.8043	0.9459	0.7751	ATP1A1/UGT1A6/SLC5A1/SLC2A1/CFTR/HMGCR/FXYD2/CA2/ADCY1/ATP1B1/NCEH1/SLC9A3/ADCY8/CYP3A4	14
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	82/1523	476/8135	0.8214	0.9626	0.7887	WNT16/GPX2/CALML3/CALM3/CALML5/HRAS/GPR37/CSNK2A2/WNT3/MAPT/NOS1/MFN1/WNT4/DKK2/VCP/SPTBN2/FZD8/MAPK12/PIK3R4/CSF1/TUBA3C/PSMD11/TUBA4A/PSMB7/RYR1/SLC25A5/WNT1/CSNK1A1/TNFRSF1B/UBE2G1/MAP2K1/WNT5B/KLC3/CYBB/TUBB3/FRAT1/ITPR2/GPX1/CAPN1/MTOR/MAPK13/DNALI1/WNT10A/DKK1/PRKCA/PPP3R1/PSMC6/CAPN2/DCTN5/FZD6/TUBB2A/RAF1/DNAH8/NDUFA1/TUBA8/RYR3/SDHA/GNAQ/BAX/SDHB/DNAH6/WNT2B/PSMB2/PPID/CCS/MAP1LC3A/DLG4/WNT5A/PSMD2/CACNA1D/RPS27A/NDUFA6/DNAH17/DERL1/TUBAL3/PLCB2/UQCRB/UBA7/DNAH3/GRIN2A/BID/ALS2	82
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	5/1523	36/8135	0.8307	0.9661	0.7917	NMNAT3/CD38/NT5M/NUDT12/BST1	5
KEGG	hsa00515	Mannose type O-glycan biosynthesis	3/1523	23/8135	0.8328	0.9661	0.7917	B3GALNT2/FUT4/MGAT5B	3
KEGG	hsa00020	Citrate cycle (TCA cycle)	4/1523	30/8135	0.8399	0.9661	0.7917	SDHA/SDHB/PDHA1/SUCLG1	4
KEGG	hsa00030	Pentose phosphate pathway	4/1523	30/8135	0.8399	0.9661	0.7917	GPI/FBP1/PGM2/ALDOB	4
KEGG	hsa00053	Ascorbate and aldarate metabolism	4/1523	30/8135	0.8399	0.9661	0.7917	UGT1A6/GUSB/ALDH7A1/ALDH3A2	4
KEGG	hsa00860	Porphyrin metabolism	6/1523	43/8135	0.8417	0.9661	0.7917	UGT1A6/MMAB/COX10/GUSB/UROD/EARS2	6
KEGG	hsa04979	Cholesterol metabolism	7/1523	50/8135	0.8522	0.9748	0.7987	OSBPL5/STAR/LRPAP1/APOA1/NCEH1/LIPG/STARD3	7
KEGG	hsa04217	Necroptosis	25/1523	159/8135	0.8613	0.9818	0.8045	CHMP4C/PLA2G4F/HSP90AA1/PLA2G4D/FTL/PLA2G4C/FTH1/VPS4B/SLC25A5/CYBB/CAPN1/TLR4/GLUL/CHMP6/CAPN2/IFNAR2/PYGM/RBCK1/BAX/PPID/MLKL/STAT5A/BID/PPIA/NLRP3	25
KEGG	hsa05340	Primary immunodeficiency	5/1523	38/8135	0.8648	0.9825	0.805	CD4/CD40/RFX5/PTPRC/TNFRSF13B	5
KEGG	hsa02010	ABC transporters	6/1523	45/8135	0.8719	0.9841	0.8064	ABCD3/ABCA12/CFTR/ABCA8/DEFB1/ABCB9	6
KEGG	hsa00920	Sulfur metabolism	1/1523	10/8135	0.8743	0.9841	0.8064	PAPSS2	1
KEGG	hsa04136	Autophagy - other	4/1523	32/8135	0.8751	0.9841	0.8064	ATG9B/PIK3R4/MTOR/ATG12	4
KEGG	hsa04950	Maturity onset diabetes of the young	3/1523	26/8135	0.8898	0.9944	0.8148	HHEX/NR5A2/HES1	3
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	16/1523	109/8135	0.8902	0.9944	0.8148	HEATR1/NXF3/CSNK2A2/NVL/RIOK1/EIF6/WDR75/UTP18/NHP2/GAR1/BMS1/RPP40/DKC1/POP1/EMG1/GNL2	16
KEGG	hsa04140	Autophagy - animal	21/1523	141/8135	0.9034	1	0.8194	HRAS/ATG9B/RRAGC/PIK3R4/MAP2K1/AKT1/PIK3R2/MTOR/PIK3R3/AKT3/PRKAA1/RAF1/MAP1LC3A/DDIT4/ATG12/CTSD/DAPK3/DAPK1/MTMR4/PIK3R1/MAP3K7	21
KEGG	hsa04260	Cardiac muscle contraction	12/1523	87/8135	0.9114	1	0.8194	ATP1A1/FXYD2/TNNT2/CACNB4/ATP1B1/CACNG3/CACNG2/MYL2/CACNB3/CACNA1D/CACNA2D4/UQCRB	12
KEGG	hsa04064	NF-kappa B signaling pathway	14/1523	104/8135	0.9395	1	0.8194	CSNK2A2/CARD14/LY96/CD40/CCL4/CCL21/CCL19/TNFSF13B/TLR4/TNFSF11/CXCL3/BCL2A1/CD14/MAP3K7	14
KEGG	hsa05206	MicroRNAs in cancer	48/1523	310/8135	0.9438	1	0.8194	ERBB3/SERPINB5/HRAS/FGFR3/PRKCE/MIRLET7D/ZEB2/EFNA3/WNT3/EFNA4/ITGB3/EZH2/ROCK1/DNMT3B/SHC4/MAP2K1/EFNA1/PIK3R2/MTOR/CCNE2/PDCD4/ITGA5/SLC7A1/KIF23/PIK3R3/PRKCA/MIR21/BCL2L11/E2F3/RAF1/EZR/PDGFB/PAK4/RHOA/RECK/SOX4/DDIT4/GRB2/CYP24A1/TP63/HDAC2/ST14/BMF/DNMT3A/HOXD10/PIK3R1/CDKN2A/THBS1	48
KEGG	hsa04742	Taste transduction	11/1523	86/8135	0.946	1	0.8194	SCNN1G/GNB3/SCNN1B/SCN2A/HTR3A/TAS2R38/P2RY1/P2RX2/ADCY8/PLCB2/TAS2R3	11
KEGG	hsa05034	Alcoholism	27/1523	187/8135	0.9504	1	0.8194	CALML3/CALM3/CALML5/HRAS/CREB3L2/GNB3/GNAI2/HDAC3/GNAI1/GNB1/SHC4/MAP2K1/HDAC8/SLC29A3/DRD2/GNG2/SLC29A2/HDAC11/RAF1/NPY/GNG10/GRB2/HDAC2/GNG4/SLC18A1/GRIN2A/PPP1R1B	27
KEGG	hsa05160	Hepatitis C	22/1523	157/8135	0.9527	1	0.8194	OCLN/PPP2R2C/CLDN1/HRAS/CLDN8/CLDN10/CLDN4/MAP2K1/AKT1/YWHAZ/PIK3R2/PIK3R3/AKT3/E2F3/IFNAR2/RAF1/PPP2R2A/BAX/GRB2/PIK3R1/BID/YWHAB	22
KEGG	hsa04215	Apoptosis - multiple species	3/1523	32/8135	0.9547	1	0.8194	BCL2L11/BAX/BID	3
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1523	24/8135	0.9551	1	0.8194	B4GALT7/HS3ST3A1	2
KEGG	hsa05020	Prion disease	41/1523	273/8135	0.956	1	0.8194	C1QB/C1QA/CSNK2A2/FYN/CREB3L2/NCF4/MAPK12/TUBA3C/PSMD11/TUBA4A/PSMB7/RYR1/SLC25A5/C9/KLC3/CYBB/TUBB3/ITPR2/CYBA/PIK3R2/C1QC/MAPK13/PIK3R3/PPP3R1/PSMC6/TUBB2A/NDUFA1/TUBA8/RYR3/SDHA/BAX/SDHB/RAC2/PSMB2/PSMD2/CACNA1D/NDUFA6/TUBAL3/UQCRB/GRIN2A/PIK3R1	41
KEGG	hsa05415	Diabetic cardiomyopathy	29/1523	203/8135	0.962	1	0.8194	TGFBR2/SLC2A1/ACE/NCF4/MAPK12/SLC25A5/AKT1/CYBB/CYBA/PIK3R2/MTOR/MAPK13/PIK3R3/PRKCA/PRKCZ/AKT3/NDUFA1/SDHA/NOS3/SDHB/RAC2/GSR/NDUFA6/CTSD/PLCB2/REN/UQCRB/PIK3R1/PDHA1	29
KEGG	hsa04120	Ubiquitin mediated proteolysis	19/1523	142/8135	0.9648	1	0.8194	FBXW7/UBE4B/DDB1/CDC26/NEDD4/UBE2G1/MGRN1/RHOBTB2/CBLC/CUL4A/ANAPC7/ANAPC1/FBXO2/RPS27A/PPIL2/UBA7/UBE4A/UBE2NL/CDC16	19
KEGG	hsa05322	Systemic lupus erythematosus	18/1523	136/8135	0.9658	1	0.8194	C1QB/C1QA/HLA-DMA/HLA-DRB1/C2/FCGR2A/CD86/HLA-DRA/C9/HLA-DMB/CD40/FCGR1A/C1QC/HLA-DRB4/IL10/HLA-DPA1/ACTN1/GRIN2A	18
KEGG	hsa00380	Tryptophan metabolism	4/1523	42/8135	0.9678	1	0.8194	ACAT2/EHHADH/ALDH7A1/ALDH3A2	4
KEGG	hsa00450	Selenocompound metabolism	1/1523	17/8135	0.9706	1	0.8194	PAPSS2	1
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/1523	223/8135	0.9781	1	0.8194	GSTT1/HRAS/GSTO2/EPHX3/SLC26A9/CYP2E1/GSTA3/MAPK12/SLC25A5/MAP2K4/MAP2K1/AKT1/CYBA/PIK3R2/MAPK13/PIK3R3/AKT3/SLC26A2/SLC26A1/RAF1/NDUFA1/SDHA/GSTA4/SDHB/CBR1/HGF/GRB2/NDUFA6/UQCRB/GSTM3/PIK3R1	31
KEGG	hsa05012	Parkinson disease	38/1523	266/8135	0.9782	1	0.8194	SLC39A6/CALML3/CALM3/CALML5/SLC39A2/GPR37/MAPT/MFN1/GNAI2/TUBA3C/GNAL/PSMD11/TUBA4A/PSMB7/SLC25A5/GNAI1/UBE2G1/KLC3/TUBB3/ITPR2/PSMC6/DRD2/TUBB2A/SLC39A5/NDUFA1/TUBA8/RYR3/SDHA/BAX/SDHB/PSMB2/PSMD2/RPS27A/NDUFA6/TUBAL3/SLC18A1/UQCRB/UBA7	38
KEGG	hsa04622	RIG-I-like receptor signaling pathway	7/1523	70/8135	0.9849	1	0.8194	MAPK12/MAPK13/ISG15/ATG12/NLRX1/SIKE1/MAP3K7	7
KEGG	hsa05162	Measles	17/1523	139/8135	0.9854	1	0.8194	FCGR2B/CSNK2A2/TLR7/AKT1/PIK3R2/CCNE2/TLR4/PIK3R3/AKT3/IFNAR2/TLR2/BAX/STAT5A/PIK3R1/BID/CD46/MAP3K7	17
KEGG	hsa04623	Cytosolic DNA-sensing pathway	6/1523	63/8135	0.9857	1	0.8194	POLR3B/CCL4/AIM2/POLR1C/POLR3GL/POLR2E	6
KEGG	hsa04340	Hedgehog signaling pathway	5/1523	56/8135	0.9869	1	0.8194	KIF7/ARRB2/CSNK1A1/GLI2/MGRN1	5
KEGG	hsa03018	RNA degradation	8/1523	79/8135	0.9879	1	0.8194	BTG3/CNOT10/TTC37/CNOT1/PABPC1L2B/NUDT16/WDR61/LSM6	8
KEGG	hsa04137	Mitophagy - animal	7/1523	72/8135	0.9883	1	0.8194	HRAS/ATG9B/CSNK2A2/USP30/MFN1/MAP1LC3A/RPS27A	7
KEGG	hsa04932	Non-alcoholic fatty liver disease	19/1523	155/8135	0.9888	1	0.8194	CYP2E1/MAPK12/MAP3K11/AKT1/PIK3R2/MAPK13/PIK3R3/AKT3/BCL2L11/PRKAA1/NDUFA1/SDHA/BAX/SDHB/ADIPOQ/NDUFA6/UQCRB/PIK3R1/BID	19
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	6/1523	66/8135	0.9905	1	0.8194	FARSB/WARS2/IARS2/EARS2/NARS2/AARS2	6
KEGG	hsa05014	Amyotrophic lateral sclerosis	52/1523	364/8135	0.9907	1	0.8194	GPX2/NXF3/UBQLN4/NOS1/VCP/MAPK12/PIK3R4/TUBA3C/NUP54/PSMD11/TUBA4A/PSMB7/NUP155/TNFRSF1B/NUP205/NRG3/KLC3/TUBB3/ANXA11/GPX1/MTOR/MAPK13/DNALI1/PFN1/PPP3R1/PSMC6/DCTN5/TUBB2A/DNAH8/NDUFA1/TUBA8/SDHA/NUP35/BAX/SDHB/DNAH6/PSMB2/CHCHD10/CCS/MAP1LC3A/PSMD2/NDUFA6/DNAH17/DERL1/NRG4/TUBAL3/UQCRB/DNAH3/GRIN2A/BID/ALS2/NUP188	52
KEGG	hsa03460	Fanconi anemia pathway	4/1523	54/8135	0.9947	1	0.8194	FANCE/MUS81/HES1/BRIP1	4
KEGG	hsa03015	mRNA surveillance pathway	9/1523	97/8135	0.9968	1	0.8194	PPP2R2C/NXF3/PPP2R3A/UPF3B/PABPC1L2B/PPP2R2A/SAP18/SSU72/UPF1	9
KEGG	hsa00190	Oxidative phosphorylation	14/1523	134/8135	0.9971	1	0.8194	ATP6V1C2/ATP6V0A4/ATP12A/ATP6V0E1/ATP6V1E1/COX10/TCIRG1/NDUFA1/SDHA/SDHB/ATP6V1G3/NDUFA6/UQCRB/LHPP	14
KEGG	hsa05016	Huntington disease	40/1523	306/8135	0.9971	1	0.8194	GPX2/CLTB/CREB3L2/PIK3R4/TUBA3C/PSMD11/TUBA4A/PSMB7/SLC25A5/KCNJ10/KLC3/TUBB3/GPX1/AP2A2/MTOR/DNALI1/PSMC6/DCTN5/TUBB2A/DNAH8/NDUFA1/TUBA8/SDHA/GNAQ/BAX/SDHB/DNAH6/PSMB2/DLG4/PPARGC1A/PSMD2/NDUFA6/DNAH17/AP2M1/HDAC2/TUBAL3/PLCB2/UQCRB/DNAH3/POLR2E	40
KEGG	hsa03010	Ribosome	15/1523	158/8135	0.9996	1	0.8194	RPS4Y1/RPLP1/MRPL14/MRPL33/RPS15A/RPL31/RPLP0/RPS8/MRPS15/MRPL16/RPS18/RPS27A/MRPL21/RPS27L/RPS7	15
KEGG	hsa04714	Thermogenesis	24/1523	232/8135	0.9999	1	0.8194	HRAS/CREB3L2/ACSL5/SMARCB1/NPPA/MAPK12/RPS6KA6/COX16/MTOR/MAPK13/COX10/ADCY1/PRKAA1/BMP8B/NDUFA1/SDHA/SDHB/NPR1/GRB2/PPARGC1A/ADCY8/NDUFA6/UQCRB/SMARCA4	24
KEGG	hsa05168	Herpes simplex virus 1 infection	63/1523	495/8135	0.9999	1	0.8194	ZNF100/POU2F3/ZFP57/SRPK1/NXF3/ZNF93/ZNF589/ZNF354B/HLA-DMA/HLA-DRB1/ZNF440/CD74/ITGB3/ZNF549/TAPBP/ZNF417/HLA-B/HLA-DRA/HLA-G/ZNF713/ZNF641/BST2/HLA-DMB/ZNF823/AKT1/ZNF333/PIK3R2/MTOR/ZNF273/ZNF57/HLA-DRB4/ITGA5/HLA-F/ZNF19/PIK3R3/ZNF214/HLA-C/ZNF688/AKT3/IFNAR2/ZNF689/ZNF484/ZFP82/TLR2/ZNF701/BAX/ZNF577/ZNF3/ZNF25/ZNF561/ZFP90/ZNF768/PILRA/HLA-DPA1/ZNF582/CFP/ZNF267/ZNF746/PILRB/ZNF222/PIK3R1/BID/MAP3K7	63
KEGG	hsa03040	Spliceosome	7/1523	147/8135	1	1	0.8194	PHF5A/U2AF1L4/DHX15/HNRNPM/PCBP1/LSM6/DHX8	7
KEGG	hsa04740	Olfactory transduction	13/1523	440/8135	1	1	0.8194	CALML3/CALM3/CALML5/GNAL/ARRB2/OR7A5/GNB1/OR5P3/OR1Q1/OR6A2/OR7C2/OR2M4/OR2S2	13