ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04152	AMPK signaling pathway	120/6848	120/8135	8.96e-10	2.287e-07	9.802e-08	ADRA1A/PFKFB1/PPP2R2D/PCK1/CFTR/PPP2R2C/STK11/PPP2R1A/RAB11B/AKT1S1/HNF4A/SLC2A4/TSC2/INS/RPS6KB1/CREB3L3/GYS2/AKT2/IRS4/ACACA/ELAVL1/PRKAA1/PPP2R3C/CREB1/PDPK1/PFKFB4/RAB8A/RHEB/G6PC2/PPP2R5D/ADIPOQ/PRKAG1/AKT1/CAMKK2/STRADA/G6PC/FBP2/SCD5/RAB2A/RPS6KB2/PIK3R2/CPT1A/PPP2R5C/LIPE/PPP2CB/CRTC2/ADIPOR1/EEF2/CAB39L/PFKFB2/PPP2R5E/G6PC3/PRKAB1/MAP3K7/PFKL/PRKAA2/PPP2R1B/FASN/AKT3/PPP2R5A/PPP2R2A/MLYCD/CAB39/RPTOR/RAB14/CREB3L1/CREB3/ADIPOR2/SCD/PPP2R5B/SREBF1/PRKAG3/TSC1/PIK3CB/CPT1C/PPP2R3A/GYS1/LEP/PRKAG2/PRKAB2/PIK3R3/ACACB/PPP2CA/PFKM/PIK3R1/FOXO3/CREB3L4/CPT1B/MTOR/RAB10/PPP2R3B/CREB3L2/TBC1D1/STRADB/PPP2R2B/PCK2/PIK3CA/LEPR/IGF1R/SIRT1/PIK3CD/HMGCR/EEF2K/CCNA2/INSR/CCNA1/EIF4EBP1/FOXO1/PFKP/CREB5/PPARG/ULK1/CCND1/FBP1/IRS1/PPARGC1A/IGF1/CD36/PFKFB3/IRS2	120
KEGG	hsa05205	Proteoglycans in cancer	199/6848	205/8135	1.67e-09	2.287e-07	9.802e-08	ESR1/IHH/PTPN11/ERBB3/TFAP4/FASLG/WNT10A/MAPK11/PTK2/PRKCG/PRKCB/CAMK2B/SMAD2/RPS6/PRKACB/ROCK1/WNT16/CD63/ERBB2/TP53/ARHGEF1/DCN/RPS6KB1/PRKACA/WNT2B/NANOG/MAPK12/ARAF/HPSE2/MAPK1/WNT3/ITGB1/AKT2/SHH/WNT6/WNT10B/ERBB4/PPP1R12B/KRAS/MAPK14/WNT8B/EGFR/PDPK1/PLCG2/VTN/MAPK3/CTTN/SRC/ROCK2/WNT1/PPP1CC/VAV2/CBL/RAF1/IL12B/AKT1/ELK1/FZD9/VAV1/MMP2/WNT7B/PLCG1/WNT7A/RAC1/CAV3/RHOA/RPS6KB2/FLNA/PIK3R2/PPP1CB/FZD3/ITGB3/RDX/PTPN6/FN1/TGFB1/SLC9A1/GRB2/ACTB/ITGA5/ARHGEF12/AKT3/WNT8A/PPP1CA/PTCH1/FZD1/PPP1R12C/BRAF/MAP2K2/FRS2/PRKCA/PRKACG/WNT9B/HIF1A/ITPR2/LUM/DROSHA/HSPG2/CAMK2A/RRAS/MDM2/WNT11/STAT3/PIK3CB/MRAS/CASP3/SOS2/SMO/GPC1/ACTG1/RRAS2/EIF4B/ITPR3/WNT9A/PXN/NUDT16L1/DDX5/COL1A1/HRAS/CAMK2G/ITGAV/COL1A2/PAK1/PIK3R3/PPP1R12A/WNT5B/SDC2/CTSL/VAV3/SOS1/NRAS/CDKN1A/PIK3R1/MAP2K1/KDR/CD44/ANK2/MMP9/MTOR/CDC42/MET/MYC/CAV1/TNF/PLAU/MSN/FZD8/PIK3CA/ITGB5/IGF1R/FZD4/CAMK2D/CAV2/IQGAP1/PIK3CD/ITPR1/ANK1/EZR/FLNB/FAS/TLR2/FZD5/IGF2/VEGFA/HGF/FZD6/GAB1/TIMP3/MAPK13/HPSE/FLNC/SDC1/TLR4/FZD2/PLCE1/TIAM1/PLAUR/CCND1/HSPB2/WNT4/PDCD4/THBS1/HCLS1/SDC4/TGFB2/HBEGF/ITGA2/TWIST2/WNT5A/ANK3/MIR21/FGF2/IGF1/FZD7/TWIST1/HOXD10/WNT2/GPC3/CTNNB1	199
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	148/6848	150/8135	2.054e-09	2.287e-07	9.802e-08	ATP2B2/ADRA1A/CACNG4/CACNG8/PPP2R2D/PLCB2/MYH6/ATF2/PPP2R2C/CACNG2/ATP1A4/MAPK11/RYR2/PPP2R1A/CACNA1D/KCNE1/TNNT2/ADRB1/CACNG6/AGTR2/CAMK2B/ATP2B3/PRKACB/ADRA1B/FXYD2/CACNG3/ATP2A1/SCN7A/GNAS/PIK3R5/PIK3CG/ATP1A2/ATP1B4/BCL2/TNNI3/PRKACA/SLC8A3/MAPK12/CREB3L3/ATP1B2/MAPK1/CACNA2D1/CALML4/KCNQ1/AKT2/RAPGEF3/PPP2R3C/MYL4/ATP2A3/MAPK14/ADRA1D/CREB1/TNNC1/CACNB1/GNAI3/MAPK3/ATP1A1/MYL2/PPP1CC/PPP2R5D/CACNA1S/CALM2/CACNG7/PIK3R6/CACNG5/PPP1R1A/AKT1/SLC8A2/ADCY2/ATP2A2/PLN/ADCY1/ATP1B3/PPP1CB/PPP2R5C/CALML6/PLCB3/PPP2CB/ATF6B/ADCY9/ATP1A3/CALM3/SLC9A1/PPP2R5E/SCN4B/CACNA2D4/ADCY5/SCN5A/PPP2R1B/AKT3/PPP2R5A/TPM4/PPP1CA/CACNA1F/MYL3/GNAI2/PPP2R2A/PRKCA/CALML3/PRKACG/ADCY3/CREB3L1/CACNA2D2/CALML5/GNAQ/CACNB2/CREB3/PPP2R5B/CAMK2A/ADCY6/MYH7/TPM2/SLC8A1/CREM/ADCY7/PPP2R3A/TPM3/CACNB3/CAMK2G/PPP2CA/CACNA1C/CALM1/ATF4/CREB3L4/RPS6KA5/ATP2B4/ADRB2/TPM1/PPP2R3B/CREB3L2/CACNB4/PLCB1/PPP2R2B/CAMK2D/ADCY8/RAPGEF4/SCN1B/MAPK13/GNAI1/CREB5/ADCY4/PLCB4/CACNA2D3/ACTC1/ATP1B1/AGT/AGTR1/ATP2B1	148
KEGG	hsa05165	Human papillomavirus infection	312/6848	331/8135	8.791e-09	6.169e-07	2.644e-07	HES2/COL4A6/PPP2R2D/LAMB4/PPP2R2C/ATP6V1C2/NOTCH3/FASLG/WNT10A/ATP6V0C/PPP2R1A/TERT/PTK2/ITGB6/LAMA3/TADA3/ATP6V0A1/ITGB4/ATP6V1F/ATP6V0D2/LLGL1/IRF3/VWF/PRKACB/WNT16/NFX1/COL2A1/ITGA2B/GNAS/TP53/ATP6V0E1/TSC2/RPS6KB1/RFNG/ITGA9/PRKACA/TNR/WNT2B/PATJ/ATP6V1B1/CREB3L3/IFNA6/MAPK1/ATP6V0D1/WNT3/ITGB1/AKT2/LAMC3/WNT6/WNT10B/IFNB1/PPP2R3C/ATP6V0A4/COL4A5/KRAS/APC2/CREB1/BAD/LLGL2/HEYL/WNT8B/TNFRSF1A/IFNA2/EGFR/EGF/VTN/MAPK3/ATP6V1G3/RB1/WNT1/RHEB/AXIN1/CSNK1A1/PPP2R5D/IFNA5/RAF1/PARD6A/CRB3/TUBG2/COL9A1/AKT1/IKBKG/ATP6V1D/FZD9/COL6A1/IKBKB/HES7/TBP/BCAP31/WNT7B/ATP6V1E1/TRADD/ATP6AP1/WNT7A/PSMC1/COL6A2/MAGI1/DLG2/E2F1/PARD6G/UBR4/RPS6KB2/TYK2/PIK3R2/PPP2R5C/DLG3/FZD3/MFNG/ITGB7/ITGB3/RBL1/PPP2CB/AXIN2/FN1/IFNA1/CDK2/PSEN1/DVL3/PKM/CHAD/CASP8/PPP2R5E/GRB2/COL4A3/ITGA5/PPP2R1B/IFNA14/DVL1/RBPJL/AKT3/PARD6B/PPP2R5A/TCIRG1/WNT8A/MPP5/TNN/FZD1/PPP2R2A/MAP2K2/PTEN/LAMA4/APC/MAML3/PRKACG/WNT9B/CREB3L1/COL9A2/CDK4/ATP6V1G2/IFNA16/DVL2/CHUK/ATP6V1E2/IFNA8/HLA-G/COL6A3/DLG1/CREB3/PPP2R5B/ITGA11/ATM/CREBBP/TBK1/SCRIB/HES5/PRKCZ/LAMC1/TCF7/RELA/ATP6V1C1/CCND3/HDAC1/NOTCH2/NOTCH4/TSC1/MDM2/COL9A3/TBPL1/WNT11/PIK3CB/NOTCH1/CASP3/SOS2/JAK1/ATR/ATP6V1A/PPP2R3A/LAMB2/HES6/WNT9A/PARD3/ATP6V1G1/PXN/RELN/HEY2/IKBKE/GSK3B/LAMA5/COL1A1/ATP6V1H/HRAS/THBS3/ATP6V1B2/ITGAV/COL1A2/RBL2/PIK3R3/IRF9/PPP2CA/WNT5B/ATP6V0B/SOS1/ITGA8/NRAS/EIF2AK2/CDKN1A/PDGFRB/ATP6V0A2/PIK3R1/EP300/UBE3A/ITGA3/HDAC2/CREB3L4/MAP2K1/SLC9A3R1/BAX/FADD/CHD4/MTOR/HLA-F/PRKCI/PPP2R3B/CDC42/STAT2/CREB3L2/BAK1/TUBG1/PPP2R2B/IFNAR1/ITGA7/TNF/CCND2/FZD8/PIK3CA/LFNG/ITGB5/COL4A2/FZD4/ATP6V0E2/CCNE1/TCF7L1/THBS2/PIK3CD/FAS/TLR3/TICAM1/MAML2/TRAF3/LAMB1/ITGA4/HLA-E/FZD5/CCNA2/VEGFA/SPP1/STAT1/IFNA21/FZD6/LAMA1/LAMC2/ITGA1/CCNA1/EIF4EBP1/FOXO1/COL4A1/CDK6/ISG15/CREB5/HEY1/ITGB8/ITGA10/ITGA6/PTGER4/HES4/FZD2/JAG1/TCF7L2/CCNE2/CCND1/OASL/COMP/MX1/WNT4/THBS1/CDKN1B/LAMA2/MX2/ITGA2/WNT5A/IBSP/NFKB1/IFNAR2/COL4A4/TNC/FZD7/COL6A6/HES1/WNT2/LAMB3/IRF1/CTNNB1	312
KEGG	hsa04934	Cushing syndrome	152/6848	155/8135	9.235e-09	6.169e-07	2.644e-07	PLCB2/KCNK3/CACNA1I/ATF2/AIPL1/ASH2L/WNT10A/CACNA1D/CAMK2B/MRAP/KMT2D/PRKACB/CRHR1/PDE11A/KCNA4/WNT16/GNAS/RAP1A/MC2R/ARMC5/PRKACA/WNT2B/CREB3L3/MAPK1/E2F2/POMC/WNT3/WNT6/NR5A1/WNT10B/CRH/HSD3B2/APC2/CREB1/HSD3B1/WNT8B/CDKN2A/EGFR/ARNT/CYP17A1/CYP11B1/GNAI3/MAPK3/RB1/WNT1/AXIN1/CACNA1S/SP1/FZD9/WNT7B/WNT7A/CACNA1G/ADCY2/E2F1/ADCY1/CACNA1H/CRHR2/FZD3/SCARB1/PLCB3/AXIN2/ATF6B/ADCY9/CDK2/DVL3/ADCY5/DVL1/WNT8A/CACNA1F/GNAI2/FZD1/BRAF/MAP2K2/STAR/APC/PRKACG/WNT9B/ADCY3/CREB3L1/CDK4/DVL2/ITPR2/GNAQ/CREB3/MEN1/WDR5/LEF1/CAMK2A/KMT2A/ADCY6/TCF7/USP8/RAP1B/WNT11/AIP/PDE8A/ADCY7/E2F3/ITPR3/WNT9A/GSK3B/FH/CAMK2G/CACNA1C/WNT5B/ORAI1/CDKN1A/CYP11A1/ATF4/CREB3L4/MAP2K1/WDR5B/CREB3L2/PLCB1/PBX1/FZD8/FZD4/CAMK2D/CCNE1/ADCY8/PDE8B/TCF7L1/GNA11/ITPR1/KCNK2/FZD5/FZD6/LDLR/CDKN2C/CDK6/CDKN2B/GNAI1/NR4A1/CREB5/FZD2/ADCY4/PLCB4/TCF7L2/CCNE2/CCND1/WNT4/CDKN1B/RASD1/AHR/WNT5A/NCEH1/AGT/AGTR1/FZD7/RBBP5/WNT2/CTNNB1	152
KEGG	hsa04022	cGMP-PKG signaling pathway	163/6848	167/8135	1.138e-08	6.337e-07	2.716e-07	ATP2B2/ADRB3/CNGB1/ADRA1A/GATA4/PLCB2/GNA13/GTF2I/MYH6/ATF2/KNG1/ATP1A4/CACNA1D/PPP3CB/ADRB1/SLC25A31/OPRD1/ATP2B3/ADRA1B/NPPA/ROCK1/BORCS8-MEF2B/PPP3R2/FXYD2/ATP2A1/CNGA1/PIK3R5/PIK3CG/INS/ATP1A2/ATP1B4/SLC8A3/CREB3L3/ATP1B2/MAPK1/ADORA3/KCNU1/CALML4/AKT2/PDE2A/IRS4/NOS3/ATP2A3/ADRA2B/ADRA1D/CREB1/BAD/NPR1/MYLK4/VDAC3/GNAI3/MAPK3/ATP1A1/ROCK2/PPP1CC/RAF1/CACNA1S/CALM2/PIK3R6/AKT1/SLC8A2/VDAC2/MYLK2/SLC25A6/MYLK3/PDE3B/ADCY2/ATP2A2/RHOA/PLN/ADCY1/ATP1B3/GNA12/PPP1CB/NPPB/CALML6/PLCB3/NFATC2/ATF6B/ADCY9/ATP1A3/PRKCE/CALM3/KCNMB3/ADCY5/MEF2D/AKT3/PPP1CA/CACNA1F/GNAI2/MAP2K2/CALML3/ADCY3/CREB3L1/SLC25A5/ITPR2/GUCY1A1/CALML5/PDE3A/GNAQ/CREB3/ADCY6/NPPC/MYH7/SLC8A1/SLC25A4/SRF/ADCY7/ITPR3/MEF2C/PPP3CA/NFATC3/MYL9/PPP1R12A/CACNA1C/CALM1/ATF4/NFATC4/CREB3L4/MAP2K1/PRKG1/VDAC1/PPIF/GUCY1B1/ADRA2C/ATP2B4/ADRB2/VASP/NPR2/CREB3L2/PLCB1/KCNMB1/ADORA1/ADCY8/KCNMB2/TRPC6/GNA11/ITPR1/GTF2IRD1/INSR/GUCY1A2/MRVI1/EDNRA/MYLK/GNAI1/CREB5/PDE5A/PRKG2/ADCY4/PLCB4/RGS2/KCNMB4/KCNJ8/MEF2A/IRS1/NFATC1/ATP1B1/PPP3R1/AGTR1/IRS2/ATP2B1/EDNRB/BDKRB2	163
KEGG	hsa04510	Focal adhesion	194/6848	201/8135	1.665e-08	7.051e-07	3.022e-07	COL4A6/PAK5/LAMB4/PAK4/PDGFB/PTK2/ITGB6/LAMA3/PRKCG/PRKCB/RASGRF1/ITGB4/VWF/ROCK1/COL2A1/ITGA2B/ERBB2/RAP1A/PAK6/BCL2/ITGA9/TNR/PDGFRA/MAPK1/ITGB1/AKT2/LAMC3/ILK/DOCK1/RAPGEF1/MYL10/RAC3/PPP1R12B/COL4A5/BAD/EGFR/PDPK1/MYLK4/EGF/VTN/ARHGAP35/BCAR1/MAPK3/SRC/ROCK2/MYL2/PPP1CC/MAPK9/VAV2/RAF1/PAK2/MYLPF/MYL12B/COL9A1/PARVG/AKT1/ELK1/COL6A1/VAV1/MYLK2/PIP5K1C/TLN1/MYLK3/PARVA/COL6A2/RAC1/CAV3/RHOA/SHC1/FLNA/PIK3R2/PPP1CB/ITGB7/ITGB3/FN1/PIP5K1B/CHAD/GRB2/ZYX/MYL12A/COL4A3/ACTB/ITGA5/PARVB/AKT3/TNN/PPP1CA/ACTN4/PPP1R12C/BRAF/SHC4/PTEN/CAPN2/LAMA4/PRKCA/MYL5/DIAPH1/COL9A2/CRKL/SHC3/COL6A3/MAPK8/ITGA11/XIAP/VEGFB/LAMC1/CRK/CCND3/RAP1B/COL9A3/VCL/PIK3CB/SOS2/ACTG1/TLN2/LAMB2/PXN/RELN/GSK3B/LAMA5/PIP5K1A/COL1A1/HRAS/THBS3/MYL9/ITGAV/COL1A2/PAK1/PIK3R3/PPP1R12A/VAV3/SOS1/ITGA8/PDGFRB/PIK3R1/ITGA3/MAP2K1/BIRC2/KDR/PDGFC/VASP/CDC42/RAC2/MET/PAK3/CAV1/SHC2/ITGA7/CCND2/PIK3CA/ITGB5/IGF1R/COL4A2/ARHGAP5/CAV2/THBS2/PIK3CD/FLNB/FYN/LAMB1/ITGA4/PDGFD/VEGFA/SPP1/ACTN1/FLT1/HGF/LAMA1/LAMC2/ITGA1/MAPK10/COL4A1/MYLK/FLNC/VEGFC/ITGB8/ITGA10/ITGA6/PGF/CCND1/VEGFD/COMP/THBS1/LAMA2/ITGA2/IBSP/PDGFA/JUN/COL4A4/IGF1/TNC/COL6A6/LAMB3/CTNNB1	194
KEGG	hsa04919	Thyroid hormone signaling pathway	120/6848	121/8135	1.816e-08	7.051e-07	3.022e-07	ESR1/GATA4/HDAC3/PLCB2/MYH6/NOTCH3/ATP1A4/PRKCG/PRKCB/PRKACB/MED24/FXYD2/ATP2A1/TP53/TSC2/MED16/ATP1A2/ATP1B4/PRKACA/ATP1B2/MED17/MED12L/MAPK1/AKT2/RXRB/ATP2A3/KRAS/BAD/SLCO1C1/PDPK1/PLCG2/MAPK3/ATP1A1/MED14/SRC/SLC16A10/RHEB/RAF1/MED12/PLCZ1/RXRG/AKT1/THRA/PLCD1/PLCG1/NCOR1/MED4/ATP2A2/PLN/ATP1B3/DIO1/PIK3R2/ITGB3/PLCB3/RXRA/ATP1A3/SLC9A1/PFKFB2/ACTB/PFKL/AKT3/MAP2K2/PRKCA/PRKACG/HIF1A/CASP9/DIO3/MED1/KAT2A/PLCD3/CREBBP/MYH7/HDAC1/NOTCH2/NOTCH4/MDM2/PIK3CB/NOTCH1/ACTG1/GSK3B/HRAS/ITGAV/PIK3R3/NCOA1/NRAS/PFKM/PIK3R1/EP300/HDAC2/PLCD4/MAP2K1/MTOR/DIO2/SLC16A2/MYC/MED27/PLCB1/NCOA3/PIK3CA/MED13/PIK3CD/TBC1D4/STAT1/RCAN1/SIN3A/FOXO1/PFKP/KAT2B/PLCE1/MED30/THRB/PLCB4/CCND1/MED13L/BMP4/WNT4/RCAN2/ATP1B1/SLC2A1/CTNNB1	120
KEGG	hsa04080	Neuroactive ligand-receptor interaction	331/6848	353/8135	1.9e-08	7.051e-07	3.022e-07	GLP1R/P2RX2/ADRB3/GRIN1/GRIK2/GRM8/CALCA/ADRA1A/GRIK5/GABRB2/TACR1/GNRHR/CHRNA3/GLRA3/GRIN3A/AVP/PATE2/GRM5/GHSR/OPRM1/GABRA5/GH1/UTS2/KNG1/AVPR2/GRIA2/NPY2R/CNR1/GRM1/GPR156/CYSLTR1/CALCR/GABRG1/P2RY1/P2RX1/UCN3/GRM7/P2RY10/F2/GABRA1/RLN3/GRIA4/BRS3/RLN2/DRD2/FPR2/ADRB1/HRH3/PATE1/GABRA6/AGTR2/HTR4/GABRR2/GLRA2/SSTR5/HTR2C/SSTR3/P2RY13/LTB4R/GPR50/AVPR1A/SCTR/GABRA4/GHRHR/OPRD1/GABRG2/HRH4/INSL5/CHRNA6/CCK/OPRK1/TAAR8/ADRA1B/PYY/GRM2/CRHR1/TSHB/MCHR2/GRIN2C/NTSR2/MCHR1/GRIK1/FPR3/FSHR/LPAR2/DRD3/EDN3/CHRNA4/MC2R/GABRR1/RLN1/LHCGR/ADCYAP1/CCKBR/GABRA2/HTR1A/PLG/HTR1D/FPR1/GRM3/PTAFR/GRM4/P2RX5/GH2/ADORA3/MC4R/PTH2/CHRNB2/POMC/VIPR2/PRSS3/CHRNA2/NMUR2/GRID1/GLRA1/GRIK3/GRIN2B/LPAR3/CHRNA1/P2RY8/VIP/CRH/CHRNB4/CYSLTR2/P2RY4/MTNR1B/S1PR4/GRPR/GRP/GIPR/TSHR/ADRA2B/NPFFR1/TACR3/ADRA1D/INSL3/SLURP1/OPRL1/GABRR3/TAC3/HCRTR1/PRSS1/PTH/NTSR1/UTS2R/P2RX3/KISS1/GHRL/PPY/ADM2/TAAR9/S1PR5/NMBR/GABRA3/CHRM3/ADCYAP1R1/NPFFR2/AVPR1B/CSH2/IAPP/GABRQ/GRID2/GALR2/GZMA/HTR5A/THRA/NPY5R/HTR1F/HTR7/SSTR4/CCKAR/RXFP3/PRLR/CHRNA10/FSHB/GLP2R/PRL/CALCB/CHRM2/NTS/APLNR/DRD5/GCG/RXFP2/P2RY14/GALR1/TACR2/GPHA2/HTR1E/GABBR2/HRH2/NPW/PTGDR/PDYN/CHRM4/CHRNB1/TAAR2/GRIK4/GALP/SST/VIPR1/CRHR2/SCT/EDN2/HCRTR2/CHRNB3/MLNR/GCGR/GHRH/UTS2B/CSH1/TAAR5/NPB/GABRD/CHRM1/NPBWR1/GALR3/UCN/OXT/NMUR1/TBXA2R/GIP/TRHR/CHRM5/PRLHR/C5AR1/CNR2/NPY4R/PTGER1/MLN/PMCH/GRIN3B/CTSG/HTR1B/PTH1R/GRIN2D/PTH2R/GABRB1/CHRND/GPR35/MC3R/CHRNG/NPFF/GNRH2/MC1R/P2RY11/TSPO/SSTR2/NMU/PRLH/GRM6/GABRG3/UCN2/CGA/LYNX1/HTR6/P2RY2/APLN/GABRB3/GABBR1/TRH/PRSS2/MC5R/GPR83/GLRB/HCRT/DRD4/NPY/PARD3/LEP/PTGIR/CHRNA5/GABRP/CALCRL/LYPD6/CHRNE/GRIN2A/TAC4/LPAR1/NPY1R/TRPV1/C3AR1/P2RX4/LPAR4/ADRA2C/GNRH1/ADRB2/NR3C1/ADM/PTGER3/MAS1/S1PR2/C5/GRIA1/DRD1/ADORA1/LEPR/SSTR1/P2RY6/GRIA3/GABRE/KISS1R/PTGFR/EDNRA/LYPD6B/PTGER4/GHR/GAL/LPAR6/F2RL1/THRB/P2RX7/F2RL2/HRH1/S1PR3/ADORA2B/HTR2A/C3/S1PR1/AGT/HTR2B/AGTR1/PTGER2/TAC1/PENK/NMB/OXTR/EDNRB/BDKRB2/BDKRB1/EDN1	331
KEGG	hsa04935	Growth hormone synthesis, secretion and action	118/6848	119/8135	2.536e-08	8.47e-07	3.63e-07	PLCB2/GHSR/ATF2/GH1/ADCY10/MAPK11/PTK2/CACNA1D/PRKCG/PRKCB/SSTR5/SSTR3/IGFALS/GHRHR/POU1F1/PRKACB/GNAS/PRKACA/MAPK12/CREB3L3/MAPK1/GH2/AKT2/IRS4/KRAS/MAPK14/CREB1/PLCG2/GNAI3/BCAR1/MAPK3/MAPK9/GHRL/RAF1/CACNA1S/CSH2/AKT1/PLCG1/MAP2K4/ADCY2/SHC1/ADCY1/PIK3R2/SST/PLCB3/GHRH/CSH1/ATF6B/ADCY9/GRB2/ADCY5/AKT3/CACNA1F/GNAI2/SHC4/MAP2K2/PRKCA/PRKACG/ADCY3/CREB3L1/STAT5B/SSTR2/CRKL/SHC3/ITPR2/GNAQ/CREB3/MAPK8/CREBBP/ADCY6/CRK/STAT3/PIK3CB/SOS2/ADCY7/ITPR3/MAP3K1/GSK3B/HRAS/PIK3R3/CACNA1C/SOS1/NRAS/PIK3R1/EP300/ATF4/CREB3L4/MAP2K1/MTOR/CREB3L2/PLCB1/MAP2K6/SHC2/PIK3CA/IGFBP3/ADCY8/SSTR1/PIK3CD/GNA11/ITPR1/STAT1/SOCS1/MAPK10/MAPK13/GNAI1/JAK2/SOCS2/CREB5/SOCS3/MAP2K3/GHR/ADCY4/PLCB4/JUNB/IRS1/IGF1/FOS/IRS2	118
KEGG	hsa04810	Regulation of actin cytoskeleton	209/6848	218/8135	3.544e-08	1.076e-06	4.613e-07	MYH14/SCIN/PAK5/GNA13/ITGAL/KNG1/CFL1/PAK4/PDGFB/ARHGEF7/F2/PTK2/LPAR5/ITGB6/IQGAP3/ITGB4/FGD3/FGF17/ROCK1/ITGA2B/LPAR2/PAK6/ARHGEF1/INS/BRK1/FGF21/ITGA9/FGF23/PDGFRA/ARAF/MAPK1/MYH11/ITGB1/DOCK1/MYL10/RAC3/PIKFYVE/PPP1R12B/SSH2/KRAS/APC2/PIP4K2B/EGFR/MYLK4/ITGAD/EGF/ARHGAP35/BCAR1/MAPK3/SRC/ROCK2/ITGAX/MYL2/PPP1CC/VAV2/ABI2/FGF3/RAF1/PAK2/CHRM3/MYLPF/MYL12B/FGF6/FGF20/FGFR3/VAV1/MYLK2/PIP5K1C/SSH1/MYLK3/CHRM2/RAC1/FGF16/RHOA/PIK3R2/GNA12/PPP1CB/CHRM4/FGF4/ITGB7/ITGB3/LIMK2/RDX/FN1/PIP5K1B/CHRM1/SLC9A1/ARHGEF4/FGF8/FGD1/CHRM5/MYL12A/GIT1/ACTB/ITGA5/ITGAM/ARHGEF12/TMSB4Y/PPP1CA/ACTN4/PPP1R12C/BRAF/MAP2K2/ACTR3/DIAPH2/APC/PFN4/MYL5/ACTR3B/DIAPH1/NCKAP1L/CRKL/ITGAE/PIP4K2A/MOS/ARPC5/MYH9/FGF22/ARPC2/WASF2/ITGA11/GSN/INSRR/NCKAP1/RRAS/CRK/SSH3/VCL/PIK3CB/MRAS/SOS2/ACTG1/DIAPH3/RRAS2/FGFR2/PXN/PIP5K1A/ACTR2/HRAS/ARPC1A/MYL9/ITGAV/PFN1/PAK1/PIK3R3/PPP1R12A/LIMK1/ACTR3C/PIP4K2C/ARPC1B/VAV3/SOS1/ITGA8/NRAS/GNG12/PFN2/PDGFRB/PIK3R1/LPAR1/ITGA3/MAP2K1/ARPC3/BAIAP2/CXCR4/ARPC4/ARPC5L/PDGFC/CYFIP2/LPAR4/CDC42/RAC2/PAK3/ITGA7/MSN/ARHGEF6/PIK3CA/ITGB5/CFL2/FGF1/IQGAP1/PIK3CD/WASF1/EZR/ITGA4/PDGFD/ACTN1/FGF7/CXCL12/ITGA1/WASL/MYLK/MYH10/ENAH/IQGAP2/ITGB8/ITGA10/ITGA6/TIAM1/FGF5/ITGB2/SPATA13/ITGA2/PDGFA/FGF2/FGF18/FGF9/BDKRB2/BDKRB1/FGF10	209
KEGG	hsa04360	Axon guidance	176/6848	182/8135	4.737e-08	1.318e-06	5.651e-07	BMP7/PTPN11/SLIT1/PAK5/SEMA6B/CFL1/PAK4/EFNA2/PTK2/DPYSL5/EPHA8/PPP3CB/LRIG2/SRGAP3/ABLIM2/SEMA6A/EPHA6/CAMK2B/ROCK1/SEMA4G/PPP3R2/UNC5C/SEMA3G/PAK6/SEMA4A/TRPC5/EFNA3/MAPK1/SEMA6C/ITGB1/SHH/ILK/RAC3/SSH2/EPHA7/PLXNA3/KRAS/PDPK1/PLCG2/GNAI3/MAPK3/SRC/ROCK2/RAF1/PAK2/PARD6A/PLXNB3/MYL12B/EPHA1/DCC/UNC5A/PLCG1/SSH1/TRPC3/EPHB4/RAC1/RHOA/PARD6G/PIK3R2/FZD3/NFATC2/LIMK2/PLXNB2/MYL12A/PLXNB1/LRRC4/ARHGEF12/PARD6B/GNAI2/RYK/PTCH1/RASA1/PRKCA/MYL5/SEMA4F/FES/PLXNA1/EPHA5/CAMK2A/PRKCZ/DPYSL2/SEMA7A/RRAS/SRGAP2/CDK5/SSH3/NTN3/PIK3CB/SMO/EFNB3/RHOD/SRGAP1/PARD3/SEMA3D/TRPC1/PPP3CA/GSK3B/BOC/EPHB3/NFATC3/HRAS/CAMK2G/MYL9/SEMA4B/PAK1/PIK3R3/LIMK1/NTN1/WNT5B/SEMA4D/NRP1/NRAS/PIK3R1/NFATC4/EPHB6/CXCR4/SEMA3F/NTNG1/NCK1/ROBO2/NEO1/TRPC4/CDC42/RAC2/SEMA5A/EFNA4/SEMA3C/UNC5B/L1CAM/MET/PAK3/ROBO3/NCK2/PLXNA4/EPHB1/PLXNC1/ABL1/PIK3CA/EPHA4/NGEF/CFL2/CAMK2D/EPHB2/TRPC6/PIK3CD/PLXNA2/FYN/ABLIM3/SEMA4C/CXCL12/SEMA3B/EPHA3/NTNG2/SEMA3E/BMPR1B/GNAI1/RGS3/ENAH/EFNA5/BMPR2/SEMA3A/ROBO1/NTN4/EPHA2/SLIT2/ABLIM1/RGMA/WNT4/EFNB2/SEMA6D/LRRC4C/SLIT3/WNT5A/EFNA1/PPP3R1/RND1	176
KEGG	hsa04024	cAMP signaling pathway	211/6848	221/8135	9.945e-08	2.555e-06	1.095e-06	GLP1R/ATP2B2/GRIN1/CNGB1/GRIN3A/AFDN/HHIP/GHSR/PDE4C/CFTR/CNGB3/GRIA2/PDE4A/ADCY10/ATP1A4/RYR2/GRIA4/CACNA1D/DRD2/ADRB1/HTR4/SSTR5/GLI1/CAMK2B/ATP2B3/PRKACB/CRHR1/TSHB/NPPA/ROCK1/GRIN2C/FXYD2/ATP2A1/FSHR/GNAS/EDN3/RAP1A/HCN4/MC2R/CAMK4/CNGA1/LHCGR/ATP1A2/ADCYAP1/ATP1B4/TNNI3/PRKACA/HTR1A/HTR1D/CREB3L3/ATP1B2/MAPK1/POMC/VIPR2/CALML4/AKT2/GRIN2B/VIP/RAPGEF3/CRH/RAC3/GIPR/TSHR/ATP2A3/CREB1/BAD/NPR1/HCAR1/GNAI3/MAPK3/ATP1A1/ROCK2/PPP1CC/MAPK9/GHRL/VAV2/CNGA4/RAF1/CACNA1S/CALM2/ADCYAP1R1/AKT1/VAV1/PPP1R1B/HTR1F/FSHB/PDE3B/CHRM2/DRD5/GCG/RAC1/PLD2/ADCY2/ATP2A2/GPHA2/HTR1E/RHOA/GABBR2/PLN/ADCY1/ATP1B3/PIK3R2/PPP1CB/SST/CALML6/CRHR2/EDN2/FFAR2/LIPE/ADCY9/ATP1A3/CHRM1/CALM3/SLC9A1/OXT/HCN2/GIP/PDE4D/GRIN3B/ADCY5/HTR1B/AKT3/PPP1CA/GRIN2D/CACNA1F/GNAI2/PTCH1/BRAF/MAP2K2/CALML3/SUCNR1/PRKACG/ADCY3/CREB3L1/SSTR2/CGA/CALML5/PDE3A/CREB3/MAPK8/CREBBP/PDE10A/CAMK2A/ADCY6/ARAP3/HTR6/RELA/RRAS/RAP1B/GABBR1/PIK3CB/ADCY7/RRAS2/NPY/PPARA/CAMK2G/MYL9/PAK1/PIK3R3/PPP1R12A/CACNA1C/VAV3/GRIN2A/ORAI1/PIK3R1/EP300/CALM1/CREB3L4/MAP2K1/NPY1R/ABCC4/FXYD1/ATP2B4/ADRB2/RAC2/CREB3L2/PTGER3/GRIA1/DRD1/PIK3CA/ADORA1/CAMK2D/ADCY8/RAPGEF4/SSTR1/ACOX1/PIK3CD/GRIA3/CNGA3/MAPK10/EDNRA/GNAI1/PLD1/CREB5/PLCE1/TIAM1/ADCY4/BDNF/SOX9/GLI3/NFATC1/PDE4B/ATP1B1/NFKB1/PTGER2/JUN/OXTR/FOS/ATP2B1/NFKBIA/EDN1	211
KEGG	hsa04020	Calcium signaling pathway	228/6848	240/8135	1.247e-07	2.974e-06	1.275e-06	NTRK3/P2RX2/ATP2B2/ADRB3/GRIN1/NOS1/ADRA1A/TACR1/ERBB3/PLCB2/TRDN/GRM5/CACNA1I/CACNA1E/GRM1/CAMK1G/PDGFB/RYR3/CYSLTR1/PDE1B/CACNA1B/P2RX1/RYR2/CACNA1D/PPP3CB/PRKCG/ADRB1/PRKCB/HTR4/HTR2C/CAMK2B/SLC25A31/AVPR1A/FGF17/ATP2B3/PRKACB/ADRA1B/NOS2/GRIN2C/PPP3R2/PTK2B/ATP2A1/GNAS/ERBB2/CAMK4/LHCGR/RET/PHKG2/CCKBR/FGF21/PRKACA/SLC8A3/FGF23/PDGFRA/PTAFR/P2RX5/CALML4/NOS3/ERBB4/CYSLTR2/GRPR/ATP2A3/MST1R/TACR3/ADRA1D/EGFR/MYLK4/HRC/VDAC3/EGF/PLCG2/TNNC1/NTSR1/P2RX3/TPCN1/FGF3/CACNA1S/CALM2/CHRM3/PLCZ1/FGF6/AVPR1B/FGF20/FGFR3/SLC8A2/TPCN2/HTR5A/VDAC2/MYLK2/HTR7/SLC25A6/PLCD1/CCKAR/PLCG1/MYLK3/CHRM2/DRD5/CACNA1G/NTRK1/FGF16/ADCY2/TACR2/ATP2A2/PHKA2/HRH2/PLN/ADCY1/CACNA1H/CALML6/RYR1/CASQ1/FGF4/PLCB3/GDNF/MCOLN1/ADCY9/CHRM1/CALM3/SPHK2/FGF8/TBXA2R/TRHR/CHRM5/PTGER1/ORAI2/CASQ2/GRIN2D/CACNA1F/PRKCA/CALML3/GNAL/PRKACG/ADCY3/CAMK1/SLC25A5/ASPH/ITPR2/FGF22/CALML5/STIM2/GNAQ/PLCD3/CAMK2A/VEGFB/HTR6/ITPKA/SLC8A1/SLC25A4/ADCY7/CACNA1A/FGFR2/ITPR3/PPP3CA/CAMK2G/MCOLN2/CACNA1C/GRIN2A/ORAI1/PDGFRB/CALM1/MST1/PHKB/PLCD4/MCU/CXCR4/KDR/NTRK2/VDAC1/PDGFC/PPIF/P2RX4/ATP2B4/ADRB2/GNA15/TNNC2/PTGER3/MET/ITPKB/PLCB1/MCOLN3/PDE1C/DRD1/FGF1/CAMK2D/ADCY8/ITPKC/CAMK1D/PHKG1/GNA11/ITPR1/CD38/PDGFD/VEGFA/FLT1/FGF7/HGF/PTGFR/ORAI3/PHKA1/EDNRA/MYLK/VEGFC/PLCE1/ADCY4/PLCB4/P2RX7/PDE1A/VEGFD/HRH1/NGF/FGF5/ADORA2B/HTR2A/SPHK1/GNA14/PDGFA/FGF2/PPP3R1/HTR2B/FGF18/AGTR1/FGF9/OXTR/ATP2B1/EDNRB/BDKRB2/BDKRB1/FGF10	228
KEGG	hsa04910	Insulin signaling pathway	134/6848	137/8135	1.511e-07	3.365e-06	1.442e-06	FLOT2/HKDC1/PCK1/PPP1R3F/PPP1R3A/EXOC7/RPS6/PRKAR1B/PRKACB/MKNK1/SLC2A4/PHKG2/TSC2/INS/RPS6KB1/PRKACA/ARAF/MAPK1/GYS2/PKLR/SORBS1/CALML4/AKT2/IRS4/ACACA/RAPGEF1/EIF4E2/PRKAA1/KRAS/BAD/PDPK1/HK3/MAPK3/PPP1CC/RHEB/MAPK9/CBL/G6PC2/RAF1/CALM2/PRKAG1/AKT1/ELK1/IKBKB/G6PC/FBP2/PDE3B/PHKA2/PRKAR2A/SHC1/RPS6KB2/PIK3R2/PPP1CB/CALML6/LIPE/CALM3/PRKAR1A/GRB2/G6PC3/PRKAB1/PRKAA2/FASN/AKT3/PPP1CA/SOCS4/BRAF/SHC4/MAP2K2/CALML3/PRKACG/INPP5A/RPTOR/CRKL/SHC3/RHOQ/CALML5/MAPK8/PYGB/SREBF1/PRKCZ/HK1/SH2B2/CRK/PRKAG3/INPPL1/TSC1/PIK3CB/SOS2/TRIP10/PYGM/PPP1R3E/GSK3B/GYS1/HRAS/PRKAG2/PRKAB2/PIK3R3/ACACB/SOS1/NRAS/PIK3R1/CALM1/PHKB/MAP2K1/PTPRF/MTOR/PRKCI/PYGL/SHC2/PCK2/EIF4E/PPP1R3D/PIK3CA/PPP1R3B/PHKG1/PIK3CD/PRKAR2B/SOCS1/HK2/INSR/EIF4EBP1/MAPK10/FOXO1/PHKA1/SOCS2/CBLB/SOCS3/MKNK2/FBP1/PTPN1/PPP1R3C/IRS1/PPARGC1A/IRS2	134
KEGG	hsa04728	Dopaminergic synapse	129/6848	132/8135	3.254e-07	6.793e-06	2.911e-06	GNAO1/PPP2R2D/KCNJ5/PLCB2/COMT/GNGT1/ATF2/GRIA2/PPP2R2C/CACNA1B/GNG4/MAPK11/PPP2R1A/GRIA4/CACNA1D/PPP3CB/PRKCG/DRD2/ARRB2/PRKCB/CAMK2B/SLC18A2/PRKACB/KCNJ3/KIF5A/GNAS/DRD3/PRKACA/MAPK12/CREB3L3/SLC18A1/CALML4/AKT2/GRIN2B/GSK3A/PPP2R3C/MAPK14/CREB1/GNG13/GNAI3/PPP1CC/MAPK9/PPP2R5D/GNG3/CALM2/KIF5B/CALY/AKT1/GNB4/PPP1R1B/DRD5/TH/PPP1CB/GNB2/PPP2R5C/CALML6/GNGT2/PLCB3/PPP2CB/KCNJ9/ATF6B/CALM3/PPP2R5E/SLC6A3/GNG10/LRTOMT/ADCY5/PPP2R1B/AKT3/PPP2R5A/GNG2/CLOCK/PPP1CA/GNAI2/PPP2R2A/GNG8/PRKCA/CALML3/GNAL/PRKACG/CREB3L1/GNG5/GNB1/ITPR2/CALML5/GNAQ/CREB3/MAPK8/PPP2R5B/CAMK2A/SCN1A/KIF5C/CACNA1A/PPP2R3A/DRD4/ITPR3/PPP3CA/GSK3B/CAMK2G/PPP2CA/CACNA1C/GRIN2A/GNG7/ARRB1/GNG12/CALM1/ATF4/CREB3L4/PPP2R3B/GNB5/CREB3L2/PLCB1/PPP2R2B/GRIA1/DRD1/MAOA/CAMK2D/ARNTL/ITPR1/GRIA3/MAPK10/MAPK13/GNAI1/KCNJ6/GNG11/CREB5/MAOB/PLCB4/FOS	129
KEGG	hsa04151	PI3K-Akt signaling pathway	329/6848	354/8135	3.503e-07	6.882e-06	2.95e-06	EPOR/COL4A6/SYK/PPP2R2D/ERBB3/TCL1A/PCK1/LAMB4/GNGT1/ATF2/GH1/JAK3/CSF3R/PDGFB/PPP2R2C/EFNA2/STK11/GNG4/FASLG/EPO/PPP2R1A/PTK2/TGFA/LPAR5/ITGB6/LAMA3/IL2RG/ITGB4/IL2RA/RPS6/VWF/FGF17/YWHAE/IL4/COL2A1/ITGA2B/LPAR2/ERBB2/SGK2/TP53/PIK3R5/PIK3CG/TSC2/INS/RPS6KB1/BCL2/FGF21/ITGA9/TNR/FGF23/PDGFRA/CREB3L3/EFNA3/IFNA6/MAPK1/GYS2/GH2/ITGB1/AKT2/LAMC3/ANGPT4/BCL2L1/NOS3/LPAR3/IFNB1/EIF4E2/ERBB4/YWHAQ/PRKAA1/PKN1/PPP2R3C/COL4A5/KRAS/CREB1/BAD/ANGPT2/PIK3AP1/IL2/IFNA2/EGFR/PDPK1/EGF/VTN/GNG13/MAPK3/RHEB/G6PC2/PPP2R5D/IFNA5/FGF3/GNG3/RAF1/MLST8/PIK3R6/FGF6/FGF20/CSH2/FGFR3/COL9A1/AKT1/GNB4/IKBKG/COL6A1/IKBKB/CD19/G6PC/CSF1R/IL2RB/PRLR/IL3RA/PRL/CHRM2/COL6A2/NTRK1/MTCP1/MAGI1/RAC1/FGF16/OSM/RPS6KB2/PIK3R2/GNB2/PPP2R5C/FGF4/GNGT2/ITGB7/ITGB3/PPP2CB/RXRA/CSH1/ATF6B/CRTC2/FN1/IFNA1/CDK2/CHRM1/HSP90AA1/FGF8/CHAD/BCL2L11/PPP2R5E/HSP90AB1/GRB2/COL4A3/G6PC3/GNG10/ITGA5/PRKAA2/MAGI2/PPP2R1B/IFNA14/AKT3/FLT3/PPP2R5A/GNG2/TNN/PPP2R2A/GNG8/MAP2K2/PTEN/LAMA4/PRKCA/RPTOR/CREB3L1/COL9A2/GNG5/GNB1/CDK4/IFNA16/CHUK/CASP9/YWHAG/FGF22/IFNA8/COL6A3/CREB3/PPP2R5B/YWHAB/ITGA11/CSF1/KITLG/VEGFB/LAMC1/OSMR/RELA/CCND3/TSC1/MDM2/FLT3LG/COL9A3/PIK3CB/BRCA1/SOS2/JAK1/SGK3/PPP2R3A/FGFR2/LAMB2/EIF4B/CDC37/RELN/GSK3B/LAMA5/GYS1/THEM4/PHLPP2/COL1A1/HRAS/THBS3/ITGAV/COL1A2/RBL2/PIK3R3/PPP2CA/SOS1/ITGA8/NRAS/GNG7/GNG12/CDKN1A/PDGFRB/PIK3R1/LPAR1/ATF4/ITGA3/FOXO3/AREG/CREB3L4/MAP2K1/KDR/NTRK2/PDGFC/PKN3/LPAR4/TEK/MTOR/PPP2R3B/GNB5/EFNA4/YWHAH/CREB3L2/MET/MYC/PPP2R2B/PCK2/IFNAR1/ITGA7/CCND2/EIF4E/MCL1/PIK3CA/ITGB5/IGF1R/COL4A2/FGF1/CCNE1/ANGPT1/THBS2/PIK3CD/TLR2/LAMB1/ITGA4/PDGFD/IGF2/VEGFA/SPP1/FLT1/FGF7/IFNA21/HGF/IL6R/LAMA1/PHLPP1/LAMC2/HSP90B1/INSR/ITGA1/EIF4EBP1/COL4A1/CDK6/JAK2/NTF3/IL4R/NR4A1/SGK1/GNG11/CREB5/VEGFC/ITGB8/ITGA10/ITGA6/PGF/TLR4/EFNA5/GHR/LPAR6/CCNE2/BDNF/CCND1/VEGFD/EPHA2/COMP/NGF/FGF5/THBS1/CDKN1B/LAMA2/ITGA2/IRS1/DDIT4/IBSP/EFNA1/PDGFA/IL7/FGF2/NFKB1/IFNAR2/FGF18/FGF9/PKN2/COL4A4/IGF1/CSF3/TNC/IL7R/COL6A6/MYB/LAMB3/FGF10	329
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	436/6848	476/8135	6.778e-07	1.258e-05	5.391e-06	NOX1/DNAH6/GRIN1/PRKN/NOS1/RPS27A/HAP1/PLCB2/DNAH3/GRM5/CYBB/TUBB1/GRIA2/GRM1/RYR3/ATF6/DCTN4/NDUFA11/CACNA1B/DNAH11/FASLG/WNT10A/MAPK11/RYR2/GRIA4/CACNA1D/PPP3CB/PRKCG/KLC4/PRKCB/GPX5/COX8C/UBB/DCTN6/CAMK2B/UBA52/KLC3/SLC25A31/UBA1/GPX2/DNAH1/DNAH12/ATP5F1C/NOS2/DNAH9/KIF5A/GRIN2C/PPP3R2/WNT16/ATP2A1/SPTBN2/PSMA8/UBC/NDUFS3/DNAH17/PSMB4/MAP1LC3B/ACTR1A/MAPT/PSMD4/BCL2/WNT2B/MAP2K7/MAPK12/DNAI2/ARAF/NDUFA10/ATP5PB/UQCRFS1/MAPK1/NDUFC2/DLG4/COX4I1/WNT3/CALML4/DCTN3/DNAH2/NDUFV1/BCL2L1/GRIN2B/SDHC/WNT6/WNT10B/ATXN2L/SMCR8/ATP5PF/ATP2A3/DNAH8/DCTN1/BECN1/RAB5A/KRAS/APC2/MAPK14/CSNK2B/BAD/COX6A1/UQCRC1/ATP5F1A/WNT8B/UQCR10/TNFRSF1A/PSMD6/VDAC3/MAP3K10/UBE2G1/CSNK2A1/RAB8A/MAPK3/NDUFB4/DNAH14/SPG11/WNT1/SNCA/PARK7/DNAH10/MAPK9/UQCRH/COX6B1/NDUFS4/DKK4/AXIN1/CSNK1A1/DKK2/TUBAL3/DCTN2/NDUFB8/RAF1/CACNA1S/CALM2/CHRM3/KIF5B/PSMC2/NDUFB9/PSMB1/COX7B2/UBE2J2/RAB1A/NDUFB10/ATXN3L/HTT/DNAI1/FZD9/PRPH/AMBRA1/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/WNT7B/PLCG1/ACTR10/COX8A/MFN2/WNT7A/TRPC3/NDUFA9/CDK5R1/PSMA1/NDUFB5/PSMC1/COX5A/UBE2L3/RAC1/DERL1/ATP2A2/SEM1/SEPTIN5/SDHD/C9orf72/CAPN1/PDYN/KLC1/VAPB/ATP5F1D/ACTR1B/CALML6/RYR1/ATP5PD/CSNK1E/UQCR11/FZD3/PSMB5/COX2/PIK3C3/PLCB3/PSMD9/SDHB/NDUFS7/AXIN2/TUBA8/MFN1/WIPI2/NDUFB2/CHMP2B/ND4/CSNK2A2/CHRM1/CALM3/ERN1/PSEN1/NDUFA2/ALS2/ATP5F1B/NDUFA6/DVL3/COX6B2/NDUFB6/CASP8/COX4I2/SLC6A3/ATG2B/NDUFB3/CHRM5/HTRA2/SOD1/COX7A2L/PSMD1/TUBA3C/DVL1/PSMD2/UQCRQ/NDUFA1/WNT8A/NDUFA5/PSMD7/GRIN2D/CACNA1F/COX7C/FZD1/TUBB4A/PSMB2/BRAF/UQCRB/DNAH5/MAP2K2/NEFH/SDHA/CAPN2/PSMC6/PRKCA/TUBA1A/CALML3/APC/DCTN5/NDUFB7/SIGMAR1/WNT9B/TARDBP/COX6C/NDUFB11/UBE2G2/IFT57/SLC25A5/DVL2/NDUFA12/NDUFA3/UBA7/CASP9/ITPR2/NDUFC1/CALML5/PSMA2/GNAQ/MAPK8/ATP5F1E/PSMD13/NDUFS2/CSF1/TBK1/CAMK2A/UBE2J1/DNAL1/NDUFB1/ATG101/RELA/PSEN2/ATP5MC3/CDK5/NDUFV2/KLC2/TUBB/PSMD8/ATP5MC2/NDUFS5/NDUFA7/CCS/WNT11/PIK3R4/ATXN2/SLC25A4/PSMB6/PSMB7/PSMD3/PSMB3/TRAP1/PRNP/TANK/CASP3/FIG4/KIF5C/PSMC5/APAF1/XBP1/ADRM1/PSMA3/CYC1/DNAL4/PSMA5/NRBF2/COX7A2/VCP/PPID/ITPR3/WNT9A/ATXN1L/PSMC3/NDUFS1/GPR37/PPP3CA/TRAF2/FUS/GSK3B/PINK1/PSMC4/HRAS/CAMK2G/HSD17B10/EIF2S1/DNAH7/CACNA1C/WNT5B/ZFYVE1/ATXN3/GRIN2A/PSMD11/NDUFS8/PSMD12/NRAS/ATG2A/GPX1/ATP5MC1/SNCAIP/CALM1/ATF4/UCHL1/MAP2K1/TUBA1C/MCU/ND5/LRP5/PSMA4/COX7B/TOMM40/DNALI1/BAX/FADD/DAXX/STX1A/GPX8/VDAC1/PPIF/PSMD14/PSMA7/UBE2L6/OPTN/MTOR/GPX3/NEFL/BAK1/PLCB1/MAP2K6/NDUFV3/TUBA1B/GRIA1/TNF/TUBB4B/FZD8/FZD4/NEFM/MAP1LC3C/CAMK2D/HSPA5/GPX7/EIF2AK3/TUBB3/RAB39B/CYCS/MAP1LC3A/ITPR1/FAS/ULK2/TUBB6/GRIA3/FZD5/APP/TOMM40L/FZD6/DDIT3/LRP6/TUBA4A/ATXN1/HIP1/MAPK10/PSMA6/CAT/MAPK13/CASP7/COX7A1/NDUFA4/MAP2K3/FZD2/NDUFA4L2/PLCB4/RB1CC1/ULK1/BDNF/FRAT2/TUBB2A/WIPI1/WNT4/DKK1/LRRK2/FRAT1/WNT5A/NOX4/NFKB1/PPP3R1/TNFRSF1B/TUBB2B/MAP3K5/BID/FZD7/WNT2/CTNNB1	436
KEGG	hsa04925	Aldosterone synthesis and secretion	97/6848	98/8135	8.245e-07	1.449e-05	6.212e-06	ATP2B2/KCNJ5/PLCB2/KCNK3/CACNA1I/ATF2/CAMK1G/ATP1A4/CACNA1D/PRKCG/PRKCB/CAMK2B/ATP2B3/PRKACB/NPPA/ATF1/GNAS/MC2R/CAMK4/ATP1A2/ATP1B4/PRKACA/CREB3L3/ATP1B2/POMC/CALML4/PDE2A/PRKD3/HSD3B2/CREB1/NPR1/HSD3B1/ATP1A1/CACNA1S/CALM2/CACNA1G/ADCY2/ADCY1/ATP1B3/CACNA1H/PRKD2/CALML6/SCARB1/PLCB3/LIPE/ATF6B/ADCY9/ATP1A3/PRKCE/CALM3/DAGLB/ADCY5/DAGLA/CACNA1F/PRKCA/STAR/CALML3/PRKACG/ADCY3/CREB3L1/CAMK1/CYP11B2/ITPR2/CALML5/GNAQ/CREB3/CAMK2A/ADCY6/PRKD1/ADCY7/KCNK9/ITPR3/CAMK2G/CACNA1C/ORAI1/CYP11A1/CALM1/ATF4/CREB3L4/ATP2B4/CREB3L2/PLCB1/CAMK2D/ADCY8/CAMK1D/GNA11/ITPR1/LDLR/NR4A1/CREB5/ADCY4/PLCB4/ATP1B1/AGT/AGTR1/NR4A2/ATP2B1	97
KEGG	hsa05226	Gastric cancer	144/6848	149/8135	9.926e-07	1.658e-05	7.105e-06	CTNNA3/WNT10A/TERT/POLK/SMAD4/SMAD2/FGF17/WNT16/ERBB2/CTNNA1/TP53/RPS6KB1/BCL2/FGF21/WNT2B/FGF23/ARAF/MAPK1/E2F2/WNT3/REG4/AKT2/SHH/CDH1/WNT6/WNT10B/RXRB/MUC2/KRAS/APC2/WNT8B/EGFR/CDH17/EGF/MAPK3/RB1/WNT1/AXIN1/CSNK1A1/ABCB1/FGF3/RAF1/FGF6/RXRG/FGF20/RARB/AKT1/FZD9/WNT7B/WNT7A/FGF16/SHC1/E2F1/RPS6KB2/PIK3R2/TGFBR2/FGF4/FZD3/RXRA/AXIN2/CDK2/TGFB1/DVL3/FGF8/GRB2/DVL1/CDX2/AKT3/CTNNA2/WNT8A/FZD1/BRAF/SHC4/MAP2K2/APC/WNT9B/DVL2/TGFB3/SHC3/MLH1/FGF22/LEF1/TCF7/SMAD3/WNT11/PIK3CB/SOS2/FGFR2/E2F3/TGFBR1/WNT9A/GSK3B/HRAS/PIK3R3/WNT5B/SOS1/NRAS/CDKN1A/PIK3R1/MAP2K1/LRP5/BAX/MTOR/MET/MYC/BAK1/SHC2/FZD8/PIK3CA/FGF1/FZD4/CCNE1/TCF7L1/PIK3CD/FZD5/FGF7/HGF/FZD6/GADD45G/LRP6/GAB1/CDKN2B/JUP/FZD2/TCF7L2/CCNE2/CCND1/FRAT2/DDB2/FGF5/WNT4/TGFB2/CDKN1B/GADD45A/FRAT1/WNT5A/FGF2/FGF18/FGF9/GADD45B/FZD7/WNT2/CTNNB1/FGF10	144
KEGG	hsa04931	Insulin resistance	106/6848	108/8135	1.695e-06	2.647e-05	1.134e-05	SLC27A2/PTPN11/PCK1/PPP1R3A/PRKCB/SLC2A4/INS/RPS6KB1/CREB3L3/NR1H2/GYS2/AKT2/NOS3/PRKAA1/CREB1/PPARGC1B/PTPA/TNFRSF1A/PDPK1/SLC27A5/PPP1CC/MAPK9/MLXIPL/G6PC2/PRKAG1/AKT1/IKBKB/G6PC/OGA/SLC2A2/MLX/MLXIP/PRKCQ/RPS6KB2/PIK3R2/PPP1CB/CPT1A/CRTC2/PRKCE/G6PC3/PRKAB1/PRKAA2/AKT3/PPP1CA/PTEN/CREB3L1/OGT/RPS6KA6/CREB3/MAPK8/RPS6KA1/PYGB/SREBF1/PRKCZ/RELA/PRKAG3/STAT3/PIK3CB/PYGM/PPP1R3E/SLC27A4/GSK3B/PPARA/GYS1/RPS6KA2/PRKAG2/PRKAB2/PIK3R3/ACACB/PIK3R1/CREB3L4/GFPT1/CPT1B/PTPRF/MTOR/CREB3L2/PYGL/PCK2/TNF/NR1H3/PPP1R3D/PIK3CA/SLC27A1/PPP1R3B/SLC27A3/PIK3CD/PRKCD/TRIB3/TBC1D4/INSR/MAPK10/FOXO1/RPS6KA3/CREB5/SOCS3/PTPN1/PPP1R3C/IRS1/PPARGC1A/NFKB1/AGT/GFPT2/CD36/SLC2A1/IRS2/NFKBIA	106
KEGG	hsa04010	MAPK signaling pathway	274/6848	294/8135	1.743e-06	2.647e-05	1.134e-05	CACNG4/CACNG8/ERBB3/CACNA1I/ATF2/PTPN5/CACNA1E/MAP3K13/PDGFB/CACNG2/EFNA2/MAP4K1/CACNA1B/FASLG/MAPK11/CACNA1D/TGFA/LAMTOR3/PPP3CB/PRKCG/MAPK8IP3/CACNG6/ARRB2/MAPK8IP2/PRKCB/ELK4/RASGRF1/TAOK2/FGF17/PRKACB/MAPK8IP1/MKNK1/PPP3R2/CACNG3/ERBB2/RAP1A/TP53/INS/MAPT/FGF21/PRKACA/FGF23/MAP2K7/PDGFRA/MAPK12/PTPN7/EFNA3/ARAF/MAPK1/CACNA2D1/PLA2G4F/NF1/AKT2/ANGPT4/HSPA6/RAC3/ERBB4/PTPRR/RASGRP4/MAP3K11/KRAS/MAPK14/ANGPT2/TNFRSF1A/EGFR/EGF/DUSP9/CACNB1/MAPK3/TRAF6/MAPK9/FGF3/RAF1/CACNA1S/PPP5C/PAK2/RASGRP3/CACNG7/TAB1/CACNG5/MAX/FGF6/FGF20/FGFR3/AKT1/ELK1/IKBKG/IKBKB/CSF1R/TRADD/DUSP8/CACNA1G/NTRK1/RAC1/FGF16/RPS6KA4/MAP2K4/MAP4K2/FLNA/GNA12/CACNA1H/IL1R1/TGFBR2/FGF4/MAP3K6/IRAK1/TGFB1/MAPKAPK2/ECSIT/FGF8/IRAK4/GRB2/STK4/MAP3K20/CACNA2D4/MAP3K7/AKT3/FLT3/CACNA1F/RASA1/BRAF/DUSP3/MAP2K2/PRKCA/PRKACG/CRKL/DUSP16/CHUK/CACNA2D2/MAPKAPK5/TGFB3/TAOK3/MAP3K2/FGF22/MAP3K3/RPS6KA6/HSPB1/CACNB2/RASGRP2/MAPK8/MAPKAPK3/RPS6KA1/CSF1/KITLG/VEGFB/RELA/RRAS/CRK/MYD88/RAP1B/FLT3LG/MAP4K4/MRAS/STMN1/MAPK7/CASP3/SRF/SOS2/CACNA1A/RRAS2/FGFR2/TGFBR1/MAP3K1/PLA2G4C/MEF2C/PPP3CA/TRAF2/CACNB3/NFATC3/HRAS/PPM1A/RPS6KA2/JUND/PAK1/CACNA1C/SOS1/HSPA1A/NRAS/ARRB1/GNG12/PDGFRB/ATF4/AREG/RASGRF2/MAP2K1/KDR/NTRK2/MAP4K3/DAXX/PDGFC/RPS6KA5/TAB2/PPM1B/DUSP7/TEK/MAP3K4/CDC42/RAC2/EFNA4/NFKB2/MET/CACNB4/MYC/TAOK1/MAP2K6/TNF/IGF1R/FGF1/CDC25B/ANGPT1/MAP3K14/MAP3K12/NLK/FLNB/HSPA1L/FAS/PDGFD/IGF2/VEGFA/STK3/FLT1/FGF7/HGF/GADD45G/IL1RAP/DDIT3/INSR/MAPK10/MAP2K5/RPS6KA3/MAPK13/FLNC/NTF3/NR4A1/VEGFC/MAP2K3/PGF/EFNA5/MECOM/DUSP1/MKNK2/DUSP6/BDNF/CACNA2D3/VEGFD/EPHA2/RASA2/RELB/NGF/FGF5/DUSP4/HSPA2/TGFB2/GADD45A/DUSP5/CD14/DUSP10/DUSP2/NFATC1/EFNA1/PDGFA/FGF2/NFKB1/PPP3R1/FGF18/FGF9/JUN/IGF1/MAP3K5/RASGRP1/FOS/GADD45B/PLA2G4A/FGF10	274
KEGG	hsa05212	Pancreatic cancer	76/6848	76/8135	1.936e-06	2.811e-05	1.205e-05	POLK/TGFA/SMAD4/SMAD2/ERBB2/TP53/RPS6KB1/ARAF/MAPK1/E2F2/AKT2/BCL2L1/RAC3/KRAS/BAD/CDKN2A/EGFR/EGF/MAPK3/RB1/MAPK9/RAF1/AKT1/IKBKG/IKBKB/RAC1/PLD2/E2F1/RPS6KB2/PIK3R2/TGFBR2/TGFB1/AKT3/BRAF/RALB/CDK4/CHUK/TGFB3/CASP9/MAPK8/RAD51/RELA/SMAD3/STAT3/PIK3CB/JAK1/E2F3/TGFBR1/BRCA2/PIK3R3/CDKN1A/PIK3R1/MAP2K1/BAX/RALGDS/RALBP1/MTOR/CDC42/RAC2/BAK1/ARHGEF6/PIK3CA/PIK3CD/RALA/VEGFA/STAT1/GADD45G/MAPK10/CDK6/PLD1/CCND1/DDB2/TGFB2/GADD45A/NFKB1/GADD45B	76
KEGG	hsa05214	Glioma	75/6848	75/8135	2.304e-06	3.118e-05	1.336e-05	CAMK1G/PDGFB/POLK/TGFA/PRKCG/PRKCB/CAMK2B/CAMK4/TP53/PDGFRA/ARAF/MAPK1/E2F2/CALML4/AKT2/KRAS/CDKN2A/EGFR/EGF/PLCG2/MAPK3/RB1/RAF1/CALM2/AKT1/PLCG1/SHC1/E2F1/PIK3R2/CALML6/CALM3/GRB2/AKT3/BRAF/SHC4/MAP2K2/PTEN/PRKCA/CALML3/CAMK1/CDK4/SHC3/CALML5/CAMK2A/MDM2/PIK3CB/SOS2/E2F3/HRAS/CAMK2G/PIK3R3/SOS1/NRAS/CDKN1A/PDGFRB/PIK3R1/CALM1/MAP2K1/BAX/MTOR/BAK1/SHC2/PIK3CA/IGF1R/CAMK2D/CAMK1D/PIK3CD/GADD45G/CDK6/CCND1/DDB2/GADD45A/PDGFA/IGF1/GADD45B	75
KEGG	hsa04722	Neurotrophin signaling pathway	116/6848	119/8135	2.338e-06	3.118e-05	1.336e-05	TP73/NTRK3/PTPN11/FASLG/MAPK11/CAMK2B/YWHAE/RAP1A/CAMK4/TP53/BCL2/MAP2K7/MAPK12/MAPK1/CALML4/AKT2/RAPGEF1/KRAS/MAPK14/BAD/PDPK1/PLCG2/MAPK3/TRAF6/MAPK9/RAF1/CALM2/AKT1/IKBKB/PLCG1/NTRK1/RAC1/RHOA/SHC1/PIK3R2/CALML6/ARHGDIG/IRAK1/MAPKAPK2/CALM3/PSEN1/IRAK4/GRB2/ARHGDIA/AKT3/PRDM4/BRAF/SHC4/MAP2K2/FRS2/ARHGDIB/CALML3/MAGED1/CRKL/SHC3/MAP3K3/CALML5/RPS6KA6/MAPK8/SH2B1/RPS6KA1/CAMK2A/BEX3/ZNF274/SH2B2/RELA/PSEN2/CRK/KIDINS220/RAP1B/PIK3CB/NFKBIB/MAPK7/SOS2/MAP3K1/GSK3B/HRAS/CAMK2G/RPS6KA2/PIK3R3/SOS1/NRAS/PIK3R1/CALM1/ATF4/FOXO3/MAP2K1/NTRK2/BAX/RPS6KA5/CDC42/SORT1/SHC2/ABL1/PIK3CA/CAMK2D/PIK3CD/PRKCD/SH2B3/GAB1/MAPK10/MAP2K5/RPS6KA3/MAPK13/NTF3/IRAK3/BDNF/NGF/IRS1/IRAK2/NFKB1/JUN/MAP3K5/NFKBIE/NFKBIA/RIPK2	116
KEGG	hsa04068	FoxO signaling pathway	127/6848	131/8135	2.427e-06	3.118e-05	1.336e-05	PCK1/GRM1/STK11/FASLG/MAPK11/SMAD4/SLC2A4/SGK2/INS/RAG1/AGAP2/MAPK12/ARAF/RAG2/MAPK1/AKT2/IRS4/PRKAA1/S1PR4/KRAS/MAPK14/FOXG1/CCNB3/EGFR/PDPK1/EGF/MAPK3/PLK1/MAPK9/G6PC2/RAF1/PRKAG1/AKT1/IKBKB/G6PC/USP7/PIK3R2/TGFBR2/CSNK1E/CDK2/TGFB1/BCL2L11/GRB2/STK4/G6PC3/PRKAB1/FOXO4/PRKAA2/AKT3/GABARAP/BRAF/MAP2K2/PTEN/ATG12/CHUK/TGFB3/MAPK8/ATM/CREBBP/SMAD3/PRKAG3/MDM2/STAT3/GABARAPL2/IL10/PIK3CB/SOS2/SGK3/TGFBR1/HRAS/CDKN2D/PRKAG2/RBL2/PRKAB2/PIK3R3/PRMT1/SOS1/NRAS/CDKN1A/SETD7/PIK3R1/EP300/SKP2/FOXO3/FBXO25/MAP2K1/HOMER3/PCK2/CCND2/PIK3CA/HOMER2/IGF1R/SIRT1/PIK3CD/PLK4/NLK/BNIP3/GADD45G/INSR/PLK3/MAPK10/FOXO1/CDKN2B/CAT/MAPK13/CCNB1/SGK1/HOMER1/CCNB2/CCND1/BCL6/KLF2/GABARAPL1/TGFB2/CCNG2/CDKN1B/GADD45A/IRS1/S1PR1/IGF1/TNFSF10/IRS2/GADD45B/IL7R/SOD2/PLK2/FBXO32	127
KEGG	hsa05032	Morphine addiction	90/6848	91/8135	2.603e-06	3.22e-05	1.38e-05	GNAO1/GABRB2/KCNJ5/PDE4C/GNGT1/OPRM1/GABRA5/GRK6/PDE1B/GABRG1/PDE4A/CACNA1B/GNG4/GABRA1/PRKCG/GABRA6/ARRB2/PRKCB/GABRR2/GABRA4/GABRG2/PRKACB/KCNJ3/PDE11A/GNAS/GABRR1/GABRA2/PRKACA/PDE2A/GABRR3/SLC32A1/GRK2/GNG13/GNAI3/GABRA3/GNG3/GABRQ/GNB4/PDE3B/ADCY2/GRK4/GABBR2/ADCY1/GNB2/GNGT2/KCNJ9/ADCY9/GABRD/GRK3/GNG10/PDE4D/ADCY5/GNG2/GABRB1/GNAI2/GNG8/PRKCA/PRKACG/ADCY3/GNG5/GNB1/GABRG3/PDE3A/PDE10A/ADCY6/GABRB3/GABBR1/PDE8A/ADCY7/CACNA1A/GABRP/GNG7/ARRB1/GNG12/PDE7A/GNB5/PDE1C/DRD1/ADORA1/ADCY8/PDE8B/GRK5/GABRE/GNAI1/KCNJ6/GNG11/ADCY4/PDE7B/PDE1A/PDE4B	90
KEGG	hsa04727	GABAergic synapse	88/6848	89/8135	3.611e-06	4.308e-05	1.846e-05	GLS2/GNAO1/GABRB2/HAP1/GNGT1/GABRA5/GABRG1/CACNA1B/GNG4/GABRA1/CACNA1D/PRKCG/SLC12A5/GABRA6/PRKCB/GABRR2/GAD2/GAD1/GABRA4/GABRG2/PRKACB/SLC6A12/GABRR1/GABRA2/PRKACA/SLC6A11/GABRR3/SLC32A1/GNG13/GNAI3/SRC/GABRA3/GNG3/CACNA1S/GABRQ/GNB4/SLC38A3/ADCY2/SLC6A13/GABBR2/ADCY1/GNB2/GNGT2/ADCY9/GABRD/SLC6A1/GNG10/ADCY5/GPHN/GNG2/GABRB1/CACNA1F/GNAI2/GABARAP/GNG8/PRKCA/NSF/PRKACG/ADCY3/GNG5/GNB1/GABRG3/ADCY6/GLS/GABARAPL2/GABRB3/GABBR1/ADCY7/CACNA1A/CACNA1C/GABRP/GNG7/GNG12/GLUL/TRAK2/SLC38A1/GNB5/ADCY8/SLC38A2/GABRE/SLC38A5/GNAI1/KCNJ6/GNG11/ADCY4/ABAT/PLCL1/GABARAPL1	88
KEGG	hsa04371	Apelin signaling pathway	134/6848	139/8135	4.071e-06	4.689e-05	2.01e-05	NOS1/PLCB2/GNA13/GNGT1/RYR3/NOTCH3/ADCY10/GNG4/RYR2/SMAD4/SMAD2/RPS6/PRKACB/NOS2/BORCS8-MEF2B/CAMK4/PIK3R5/PIK3CG/MAP1LC3B/UCP1/RPS6KB1/PRKACA/SLC8A3/MAPK1/CALML4/AKT2/CDH1/NOS3/PRKAA1/NRF1/MYL4/BECN1/KRAS/MYLK4/GNG13/GNAI3/MAPK3/MYL2/PLIN1/GNG3/RAF1/CALM2/PIK3R6/PRKAG1/AKT1/SLC8A2/GNB4/MYLK2/MYLK3/PDE3B/APLNR/ADCY2/ADCY1/RPS6KB2/GNB2/CALML6/RYR1/GNGT2/PIK3C3/PLCB3/LIPE/ADCY9/PRKCE/CALM3/SLC9A1/SPHK2/GNG10/PRKAB1/ADCY5/PRKAA2/MEF2D/AKT3/GNG2/MYL3/GNAI2/GNG8/MAP2K2/CALML3/PRKACG/ADCY3/GNG5/GNB1/HDAC4/ITPR2/CALML5/GNAQ/ADCY6/RRAS/SMAD3/APLN/PRKAG3/SLC8A1/PIK3R4/MRAS/ADCY7/RRAS2/TGFBR1/ITPR3/MEF2C/HRAS/PRKAG2/PRKAB2/NRAS/GNG7/GNG12/CALM1/MAP2K1/MTOR/TFAM/GNB5/PLCB1/HDAC5/MAP1LC3C/ADCY8/ACTA2/MAP1LC3A/ITPR1/SPP1/SERPINE1/MYLK/GNAI1/GNG11/JAG1/ADCY4/PLCB4/CCND1/KLF2/MEF2A/PLAT/SPHK1/PPARGC1A/CCN2/AGTR1/EGR1	134
KEGG	hsa05132	Salmonella infection	233/6848	249/8135	4.357e-06	4.85e-05	2.079e-05	SKP1/PTPRC/NLRP3/TUBB1/NLRC4/DCTN4/MAPK11/VPS18/KLC4/EXOC7/CYTH4/EXOC4/DCTN6/TAB3/KLC3/DNM2/DYNLRB1/KIF5A/PIK3CG/ACTR1A/RAB5C/BRK1/BCL2/MAP2K7/MAPK12/MAPK1/RPS3/DYNC1I2/TIRAP/VPS39/DCTN3/AKT2/MYL10/TLR6/PKN1/DCTN1/RAB5A/MAPK14/PIK3C2A/RHOH/TNFRSF1A/DYNC1H1/ARL8A/ELMO2/MAPK3/GAPDH/ROCK2/MYL2/TRAF6/MAPK9/TUBAL3/DCTN2/RAF1/DYNC1LI1/KIF5B/TAB1/MYLPF/MYL12B/AKT1/IKBKG/WASF3/IKBKB/FBXO22/ACTR10/TRADD/RAB7A/ACBD3/PIK3C2G/PLEKHM1/AHNAK/RAC1/MAP2K4/DYNC1I1/RHOA/RAB5B/FLNA/KLC1/ACTR1B/PIK3C3/TUBA8/ARF1/ARL8B/EXOC5/ANXA2/IRAK1/TXN2/HSP90AA1/IRAK4/CASP8/HSP90AB1/MYL12A/ACTB/DYNC1LI2/MAP3K7/DYNLL1/TUBA3C/PLEKHM2/AKT3/VPS11/CYTH1/DYNLT1/TUBB4A/CYTH3/CSE1L/EXOC2/MAP2K2/ACTR3/TUBA1A/DCTN5/PFN4/MYL5/ACTR3B/GSDMD/NCKAP1L/CHUK/ARPC5/S100A10/ARPC2/MAPK8/CASP5/CYTH2/LEF1/NCKAP1/TCF7/RELA/RRAS/VPS16/KLC2/TUBB/MYD88/VPS33A/RIPK1/PIK3CB/TNFRSF10B/CASP3/KIF5C/DYNLL2/ACTG1/DYNLT3/M6PR/ABI1/TLR5/FYCO1/TRAF2/KPNA4/ACTR2/HRAS/DYNC2H1/ARPC1A/MYL9/PFN1/PAK1/KPNA1/ACTR3C/STX10/IL18/TXN/ARPC1B/RILP/PFN2/NOD1/RAB7B/SNX33/KPNA3/MAP2K1/TUBA1C/ARPC3/LY96/BIRC2/ARPC4/BAX/ARPC5L/FADD/CYFIP2/TAB2/MLKL/GCC2/SNX18/CDC42/RIPK3/SNX9/PAK3/MYC/BAK1/MAP2K6/DYNC2LI1/TUBA1B/TNF/TUBB4B/MYO6/CASP4/PIK3CA/ARF6/RHOB/TUBB3/PYCARD/TCF7L1/PIK3CD/CYCS/FLNB/RALA/TLR2/TUBB6/RHOJ/PODXL/CASP1/PIK3C2B/VPS41/HSP90B1/TUBA4A/MAPK10/WASL/FHOD1/MAPK13/FLNC/CASP7/DYNLRB2/MAP2K3/TLR4/TCF7L2/ELMO1/RAB9A/TUBB2A/CD14/NFKB1/JUN/TUBB2B/TNFSF10/FOS/CXCL8/NFKBIA/CTNNB1/RIPK2	233
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	70/6848	70/8135	5.496e-06	5.791e-05	2.482e-05	PTPN11/ATP6V1C2/MAPK11/ATP6V0C/ATP6V0A1/ATP6V1F/ATP6V0D2/JAM3/ATP6V0E1/ATP6V1B1/MAPK12/ATP6V0D1/ATP6V0A4/MAPK14/EGFR/PLCG2/ATP6V1G3/SRC/MAPK9/IKBKG/ATP6V1D/IKBKB/CXCR2/PLCG1/ATP6V1E1/ATP6AP1/TJP1/RAC1/MAP2K4/ADAM10/F11R/GIT1/IGSF5/TCIRG1/PTPRZ1/ATP6V1G2/CHUK/ATP6V1E2/MAPK8/RELA/ATP6V1C1/CXCR1/CSK/CASP3/ATP6V1A/ATP6V1G1/ATP6V1H/ATP6V1B2/PAK1/ATP6V0B/ATP6V0A2/NOD1/CDC42/ADAM17/MET/ATP6V0E2/MAP3K14/JAM2/MAPK10/MAPK13/HBEGF/NFKB1/JUN/LYN/CXCL1/CXCL3/CXCL8/CXCL2/CCL5/NFKBIA	70
KEGG	hsa04530	Tight junction	161/6848	169/8135	5.628e-06	5.791e-05	2.482e-05	TJP3/MYH14/GATA4/PPP2R2D/AFDN/WAS/CFTR/CLDN18/PPP2R2C/STK11/CD1E/PPP2R1A/CACNA1D/CLDN19/ARHGEF18/LLGL1/TJAP1/PRKACB/ROCK1/JAM3/ERBB2/RAP1A/CLDN3/PRKACA/CGN/PATJ/MAP2K7/CD1C/MYH11/ITGB1/SYMPK/CLDN8/PRKAA1/LLGL2/CLDN6/RAB8A/CTTN/CLDN7/SRC/ROCK2/MYL2/MAPK9/RUNX1/TUBAL3/CLDN10/PARD6A/MYL12B/MARVELD3/CRB3/MPP4/PRKAG1/CLDN5/CD1A/TJP1/MYL6/YBX3/MAGI1/RAC1/RHOA/DLG2/CLDN17/PARD6G/CLDN15/DLG3/PPP2CB/RDX/TUBA8/PRKCE/CLDN4/NF2/AMOTL1/F11R/CLDN2/CD1B/MYL12A/ACTB/IGSF5/PRKAB1/SYNPO/TUBA3C/PRKAA2/PPP2R1B/PARD6B/CLDN9/MPP5/ACTN4/PPP2R2A/ACTR3/TUBA1A/PRKACG/CLDN16/ACTR3B/CDK4/ARPC5/MYH9/ARPC2/DLG1/MAPK8/SCRIB/PRKCZ/ARHGAP17/WHAMM/PRKAG3/RAPGEF6/RAB13/CLDN11/HSPA4/ACTG1/CLDN20/MAP3K1/PARD3/RAB8B/MYL6B/ACTR2/ARPC1A/MYL9/PRKAG2/PRKAB2/PPP2CA/ACTR3C/ARPC1B/EPB41L4B/CD1D/ARHGEF2/TUBA1C/ARPC3/SLC9A3R1/ARPC4/BVES/ARPC5L/PRKCI/VASP/CDC42/MARVELD2/PPP2R2B/TUBA1B/MSN/PCNA/MICALL2/EZR/AMOT/JAM2/ACTN1/NEDD4/TUBA4A/MAPK10/MYH10/TIAM1/CCND1/RAP2C/HCLS1/MPDZ/CLDN14/TJP2/NEDD4L/CGNL1/AMOTL2/JUN/CLDN23/MAP3K5/CLDN1	161
KEGG	hsa04725	Cholinergic synapse	110/6848	113/8135	5.738e-06	5.791e-05	2.482e-05	GNAO1/CHRNA3/PLCB2/GNGT1/CACNA1B/GNG4/CACNA1D/PRKCG/PRKCB/CAMK2B/CHRNA6/PRKACB/KCNJ3/KCNJ4/CHRNA4/CAMK4/PIK3R5/PIK3CG/BCL2/PRKACA/CREB3L3/MAPK1/CHRNB2/KCNQ2/KCNQ1/AKT2/SLC5A7/CHRNB4/KRAS/CREB1/GNG13/GNAI3/MAPK3/KCNQ4/GNG3/CACNA1S/CHRM3/PIK3R6/SLC18A3/AKT1/GNB4/KCNQ3/CHRM2/ADCY2/ADCY1/PIK3R2/CHRM4/GNB2/GNGT2/PLCB3/ADCY9/CHRM1/CHAT/CHRM5/GNG10/ADCY5/AKT3/GNG2/CACNA1F/GNAI2/GNG8/PRKCA/ACHE/PRKACG/ADCY3/CREB3L1/GNG5/GNB1/ITPR2/GNAQ/CREB3/CAMK2A/ADCY6/KCNJ14/PIK3CB/ADCY7/CACNA1A/ITPR3/HRAS/CAMK2G/PIK3R3/CACNA1C/NRAS/GNG7/GNG12/PIK3R1/ATF4/KCNJ12/CREB3L4/MAP2K1/GNB5/CREB3L2/PLCB1/PIK3CA/KCNQ5/CAMK2D/ADCY8/PIK3CD/GNA11/ITPR1/FYN/GNAI1/JAK2/KCNJ6/GNG11/CREB5/ADCY4/PLCB4/KCNJ2/FOS	110
KEGG	hsa05210	Colorectal cancer	85/6848	86/8135	5.895e-06	5.791e-05	2.482e-05	POLK/TGFA/SMAD4/SMAD2/TP53/RPS6KB1/BCL2/ARAF/MAPK1/AKT2/RAC3/KRAS/APC2/BAD/EGFR/EGF/MAPK3/MAPK9/AXIN1/RAF1/AKT1/DCC/RAC1/RHOA/RPS6KB2/PIK3R2/TGFBR2/AXIN2/TGFB1/BCL2L11/GRB2/AKT3/BRAF/MAP2K2/APC/RALB/TGFB3/CASP9/MLH1/MSH3/MAPK8/LEF1/TCF7/MSH6/SMAD3/PIK3CB/CASP3/SOS2/TGFBR1/APPL1/GSK3B/HRAS/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/AREG/MAP2K1/BBC3/BAX/RALGDS/MTOR/RAC2/MYC/BAK1/PIK3CA/TCF7L1/PIK3CD/CYCS/MSH2/RALA/BIRC5/GADD45G/MAPK10/TCF7L2/CCND1/DDB2/TGFB2/GADD45A/JUN/PMAIP1/FOS/GADD45B/CTNNB1	85
KEGG	hsa04713	Circadian entrainment	95/6848	97/8135	9.401e-06	8.722e-05	3.738e-05	GRIN1/NOS1/GNAO1/KCNJ5/PLCB2/CACNA1I/GNGT1/GRIA2/RYR3/ADCY10/GNG4/RYR2/GRIA4/CACNA1D/PRKCG/PRKCB/PER3/CAMK2B/PRKACB/KCNJ3/GRIN2C/GNAS/ADCYAP1/PRKACA/MAPK1/CALML4/GRIN2B/NOS1AP/MTNR1B/CREB1/GNG13/GNAI3/MAPK3/GNG3/CALM2/ADCYAP1R1/GNB4/CACNA1G/ADCY2/ADCY1/GNB2/CACNA1H/CALML6/RYR1/GNGT2/PLCB3/KCNJ9/ADCY9/CALM3/GNG10/ADCY5/GNG2/GRIN2D/GNAI2/GNG8/PRKCA/CALML3/PRKACG/ADCY3/GNG5/GNB1/GUCY1A1/CALML5/GNAQ/CAMK2A/ADCY6/ADCY7/ITPR3/CAMK2G/CACNA1C/GRIN2A/GNG7/GNG12/CALM1/PRKG1/PER2/GUCY1B1/RPS6KA5/GNB5/PLCB1/GRIA1/CAMK2D/ADCY8/ITPR1/PER1/GRIA3/GUCY1A2/GNAI1/KCNJ6/GNG11/PRKG2/ADCY4/PLCB4/RASD1/FOS	95
KEGG	hsa05215	Prostate cancer	95/6848	97/8135	9.401e-06	8.722e-05	3.738e-05	KLK3/SRD5A2/PDGFB/TGFA/TMPRSS2/ERBB2/TP53/INS/BCL2/SPINT1/PDGFRA/CREB3L3/ARAF/MAPK1/E2F2/AKT2/KRAS/CREB1/IL1R2/BAD/EGFR/PDPK1/EGF/MAPK3/RB1/RAF1/AKT1/IKBKG/IKBKB/E2F1/PIK3R2/GSTP1/CDK2/HSP90AA1/HSP90AB1/GRB2/AKT3/BRAF/MAP2K2/PTEN/CREB3L1/CHUK/CASP9/CREB3/CREBBP/LEF1/INSRR/TCF7/RELA/MDM2/PIK3CB/SOS2/ETV5/AR/FGFR2/E2F3/GSK3B/HRAS/PIK3R3/ZEB1/SOS1/NRAS/CDKN1A/PDGFRB/PIK3R1/EP300/ATF4/CREB3L4/MAP2K1/PDGFC/MMP9/MTOR/CREB3L2/PLAU/PIK3CA/IGF1R/CCNE1/TCF7L1/PIK3CD/PDGFD/HSP90B1/NKX3-1/ERG/FOXO1/CREB5/TCF7L2/CCNE2/CCND1/CDKN1B/PLAT/PDGFA/NFKB1/IGF1/NFKBIA/CTNNB1	95
KEGG	hsa05017	Spinocerebellar ataxia	137/6848	143/8135	1.069e-05	9.644e-05	4.133e-05	GRIN1/KCNC3/GRIN3A/PLCB2/GRIA2/GRM1/PRKCG/PRKCB/SLC1A6/SLC25A31/ATXN10/GRIN2C/ATP2A1/SPTBN2/PSMA8/PSMB4/PSMD4/AKT2/GRIN2B/ATXN2L/ATP2A3/BECN1/PSMD6/AFG3L2/FGF14/VDAC3/CIC/MAPK9/OPA1/PSMC2/PSMB1/KAT5/MYOD1/SP1/ATXN3L/AKT1/AMBRA1/TBP/VDAC2/SLC25A6/TRPC3/PSMA1/PSMC1/ATP2A2/SEM1/PDYN/PIK3R2/RYR1/NFYA/PSMB5/PIK3C3/PLCB3/PSMD9/WIPI2/ERN1/ATG2B/PSMD1/GRIN3B/PSMD2/RBPJL/AKT3/PSMD7/GRIN2D/PSMB2/BEAN1/PSMC6/PRKCA/SLC25A5/ATXN8OS/ITPR2/PUM2/PSMA2/GNAQ/MAPK8/PSMD13/ATG101/PSMD8/TBPL1/PIK3R4/ATXN2/SLC25A4/PSMB6/PSMB7/PIK3CB/PSMD3/PSMB3/PSMC5/XBP1/ADRM1/PSMA3/CACNA1A/PUM1/PSMA5/NRBF2/KCND3/ITPR3/ATXN1L/PSMC3/RELN/TRAF2/PSMC4/PIK3R3/ATXN3/GRIN2A/PSMD11/PSMD12/GTF2B/ATG2A/PIK3R1/MCU/PSMA4/VDAC1/PPIF/PSMD14/PSMA7/MTOR/PLCB1/GRIA1/PIK3CA/PIK3CD/CYCS/ITPR1/ULK2/GRIA3/TWNK/VLDLR/ATXN1/MAPK10/PSMA6/OMA1/PLCB4/RB1CC1/ULK1/WIPI1/DAB1/RORA/MAP3K5	137
KEGG	hsa05414	Dilated cardiomyopathy	94/6848	96/8135	1.097e-05	9.644e-05	4.133e-05	CACNG4/CACNG8/TTN/MYH6/SGCB/CACNG2/RYR2/CACNA1D/ITGB6/MYBPC3/TNNT2/ADRB1/CACNG6/ITGB4/PRKACB/CACNG3/ATP2A1/ITGA2B/GNAS/TNNI3/ITGA9/PRKACA/SLC8A3/CACNA2D1/ITGB1/ATP2A3/TNNC1/CACNB1/MYL2/CACNA1S/CACNG7/CACNG5/SLC8A2/DES/ADCY2/ATP2A2/PLN/ADCY1/ITGB7/ITGB3/ADCY9/TGFB1/ACTB/DAG1/CACNA2D4/ADCY5/ITGA5/TPM4/CACNA1F/MYL3/PRKACG/ADCY3/CACNA2D2/TGFB3/CACNB2/EMD/ITGA11/ADCY6/MYH7/TPM2/SLC8A1/ACTG1/ADCY7/TPM3/CACNB3/ITGAV/CACNA1C/ITGA8/ITGA3/LMNA/TPM1/SGCA/CACNB4/ITGA7/TNF/ITGB5/ADCY8/SGCD/ITGA4/LAMA1/ITGA1/DMD/ITGB8/ITGA10/ITGA6/ADCY4/CACNA2D3/ACTC1/TGFB2/LAMA2/SGCG/ITGA2/AGT/IGF1	94
KEGG	hsa04120	Ubiquitin mediated proteolysis	136/6848	142/8135	1.222e-05	0.0001046	4.484e-05	SKP1/FZR1/PRKN/PPIL2/RPS27A/ERCC8/UBOX5/ANAPC11/CUL7/UBB/UBE3B/UBA52/ANAPC5/UBA1/WWP2/UBE2U/FBXW11/UBE2I/ANAPC1/UBC/ANAPC2/UBE4A/HUWE1/UBE2D2/CUL1/CUL4A/WWP1/UBE2Q1/ELOB/ANAPC7/COP1/BTRC/UBE2D3/RNF7/FBXO2/CUL3/UBE2G1/UBE2Q2/TRAF6/CBL/SAE1/UBE2J2/UBA3/CDC34/RCHY1/MGRN1/CDC16/CUL5/HERC3/UBE2L3/ANAPC15/ANAPC4/STUB1/FBXO4/UBE2E3/UBE2A/KLHL9/UBA2/DET1/UBE2F/TRIP12/HERC2/CDC27/CBLC/AIRE/BIRC6/UBE2D4/PIAS2/DDB1/ANAPC13/UBE2K/PML/UBE3C/PIAS4/HERC1/PRPF19/SMURF1/CDC26/UBE2G2/BIRC7/TRIM37/ELOC/UBA7/KEAP1/PIAS1/TRIM32/XIAP/UBE2J1/RHOBTB2/ANAPC16/MDM2/UBA6/BRCA1/UBE2B/CUL2/ANAPC10/MAP3K1/VHL/UBE2R2/UBE2E2/UBE2H/UBE2D1/UBE4B/UBR5/FBXW7/UBE3A/SKP2/UBE2Z/CUL4B/UBE2O/UBE2N/SYVN1/BIRC2/PIAS3/HERC4/UBE2E1/UBE2L6/UBE2M/SIAH1/UBE2W/CDC23/FANCL/SOCS1/NEDD4/CDC20/ITCH/CBLB/SOCS3/MID1/KLHL13/DDB2/SMURF2/UBE2C/UBE2QL1/RHOBTB1/NEDD4L	136
KEGG	hsa04071	Sphingolipid signaling pathway	115/6848	119/8135	1.361e-05	0.0001136	4.871e-05	SPTLC1/PPP2R2D/PLCB2/GNA13/KNG1/PPP2R2C/MAPK11/PPP2R1A/PRKCG/PRKCB/CERS3/OPRD1/FCER1A/ROCK1/TP53/BCL2/MAPK12/MS4A2/MAPK1/ADORA3/AKT2/NOS3/RAC3/S1PR4/PPP2R3C/KRAS/MAPK14/TNFRSF1A/PDPK1/GNAI3/MAPK3/ROCK2/MAPK9/PPP2R5D/S1PR5/RAF1/AKT1/TRADD/CERS2/RAC1/PLD2/RHOA/CERS5/PIK3R2/GNA12/PPP2R5C/PLCB3/DEGS1/PPP2CB/PRKCE/SPHK2/SMPD1/PPP2R5E/SMPD2/PPP2R1B/NSMAF/AKT3/PPP2R5A/GNAI2/CERS4/PPP2R2A/MAP2K2/PTEN/SGPP2/ASAH1/PRKCA/FCER1G/SGMS2/SGPP1/CERS1/GNAQ/MAPK8/PPP2R5B/CERS6/PRKCZ/RELA/DEGS2/PIK3CB/PPP2R3A/TRAF2/SGPL1/HRAS/PIK3R3/PPP2CA/SGMS1/SPTLC2/NRAS/PIK3R1/MAP2K1/BAX/PPP2R3B/RAC2/S1PR2/PLCB1/PPP2R2B/TNF/PIK3CA/ADORA1/SPTLC3/ABCC1/PIK3CD/FYN/MAPK10/MAPK13/GNAI1/PLD1/GAB2/PLCB4/S1PR3/SPHK1/S1PR1/NFKB1/MAP3K5/BID/BDKRB2	115
KEGG	hsa04015	Rap1 signaling pathway	197/6848	210/8135	1.507e-05	0.0001228	5.262e-05	GRIN1/FYB1/GNAO1/AFDN/PLCB2/ITGAL/CNR1/PDGFB/EFNA2/P2RY1/MAPK11/LPAR5/PRKCG/DRD2/PRKCB/FGF17/RGS14/ITGA2B/LPAR2/GNAS/RAP1A/INS/FGF21/FPR1/FGF23/PDGFRA/MAPK12/EFNA3/SIPA1/MAPK1/ITGB1/CALML4/AKT2/ANGPT4/CDH1/GRIN2B/LPAR3/RAPGEF5/PRKD3/RAPGEF1/RAPGEF3/RAC3/FARP2/CTNND1/KRAS/MAPK14/ANGPT2/EGFR/EGF/SKAP1/GNAI3/BCAR1/MAPK3/SRC/VAV2/FGF3/RAF1/CALM2/RASGRP3/PARD6A/FGF6/FGF20/FGFR3/AKT1/CSF1R/VAV1/PLCG1/TLN1/MAGI1/RAC1/FGF16/ADCY2/RHOA/ADCY1/PARD6G/SIPA1L3/PIK3R2/MAGI3/PRKD2/CALML6/FGF4/ITGB3/PLCB3/ADCY9/CALM3/FGF8/ACTB/KRIT1/ADCY5/MAGI2/ITGAM/AKT3/PARD6B/APBB1IP/GNAI2/BRAF/MAP2K2/PRKCA/CALML3/PFN4/ADCY3/CRKL/RALB/FGF22/CALML5/GNAQ/RASGRP2/CSF1/KITLG/VEGFB/ADCY6/PRKCZ/ARAP3/PRKD1/RRAS/CRK/LAT/RAP1B/RAPGEF6/PIK3CB/MRAS/ACTG1/ADCY7/TLN2/FGFR2/PARD3/HRAS/PFN1/PIK3R3/VAV3/GRIN2A/NRAS/PFN2/PDGFRB/PIK3R1/LPAR1/CALM1/MAP2K1/KDR/RALGDS/RAP1GAP/PDGFC/LPAR4/TEK/PRKCI/VASP/CDC42/RAC2/EFNA4/MET/PLCB1/MAP2K6/PIK3CA/IGF1R/FGF1/ADCY8/RAPGEF4/ANGPT1/PIK3CD/RALA/PDGFD/VEGFA/SIPA1L1/FLT1/FGF7/HGF/INSR/DOCK4/MAPK13/GNAI1/ENAH/VEGFC/MAP2K3/PGF/EFNA5/PLCE1/TIAM1/ADCY4/PLCB4/SIPA1L2/VEGFD/EPHA2/NGF/FGF5/THBS1/ITGB2/ADORA2B/RASSF5/EFNA1/PDGFA/FGF2/FGF18/FGF9/IGF1/ID1/CTNNB1/FGF10	197
KEGG	hsa04141	Protein processing in endoplasmic reticulum	162/6848	171/8135	1.573e-05	0.0001251	5.362e-05	PRKCSH/SKP1/PRKN/RNF185/OS9/ATF6/DNAJB12/SEC61A2/GANAB/DERL3/UBE2D2/BCL2/CUL1/MAP2K7/SEC62/SEC24B/LMAN1/SEL1L2/HSPA6/MAN1B1/MAN1A2/MBTPS2/TRAM1/UBE2D3/FBXO2/UBXN6/UBE2G1/MAPK9/LMAN1L/MBTPS1/DNAJC5B/UBE2J2/ATXN3L/BCAP31/UGGT2/UBQLN3/DERL1/CAPN1/STUB1/DNAJC5G/NPLOC4/CRYAA/UBXN4/ATF6B/LMAN2/DDOST/ERN1/HSP90AA1/HSP90AB1/SEC31A/SIL1/PLAA/UBE2D4/P4HB/YOD1/UFD1/RAD23A/EIF2AK1/RNF5/BAG1/WFS1/DNAJC5/HSPBP1/UBXN2A/SEC24C/SSR4/NSFL1C/CAPN2/TXNDC5/RRBP1/UBE2G2/DNAJC1/RAD23B/ERP29/AMFR/SEC24A/NGLY1/MAPK8/UBE2J1/UGGT1/SEC23A/SEC61A1/UBQLN1/DNAJA2/STT3B/SEC61B/SSR2/UBXN1/DNAJC10/UBXN8/HERPUD1/DAD1/XBP1/CALR/SAR1B/VCP/ERLEC1/UBQLN4/UBQLN2/TRAF2/DERL2/SEC13/RPN2/DNAJB2/EIF2S1/PDIA3/SEC63/ATXN3/HSPA1A/UBE2D1/UBE4B/SELENOS/EIF2AK2/EDEM2/SEL1L/ATF4/ERO1A/SYVN1/DNAJA1/PDIA6/SEC24D/BAX/DNAJB1/SAR1A/ERO1B/SSR1/BAG2/MOGS/HSPA4L/PREB/BAK1/PPP1R15A/SEC31B/EDEM1/CKAP4/MAN1A1/EDEM3/TRAM1L1/HSPA5/EIF2AK3/CRYAB/EIF2AK4/FBXO6/HYOU1/HSPA1L/SSR3/DDIT3/SEC23B/HSP90B1/MAPK10/HSPH1/DNAJB11/NFE2L2/RPN1/SEC61G/DNAJC3/PDIA4/STT3A/HSPA2/MAN1C1/SVIP/MAP3K5	162
KEGG	hsa04926	Relaxin signaling pathway	124/6848	129/8135	1.626e-05	0.0001263	5.414e-05	NOS1/COL4A6/GNAO1/PLCB2/GNGT1/ATF2/GNG4/MAPK11/RLN3/RLN2/ARRB2/SMAD2/INSL5/PRKACB/NOS2/GNAS/RLN1/PRKACA/MAP2K7/MAPK12/CREB3L3/MAPK1/AKT2/NOS3/COL4A5/KRAS/MAPK14/CREB1/INSL3/EGFR/GNG13/GNAI3/MAPK3/SRC/MAPK9/GNG3/RAF1/AKT1/GNB4/MMP2/RXFP3/RXFP2/MAP2K4/ADCY2/SHC1/ADCY1/PIK3R2/GNB2/TGFBR2/GNGT2/PLCB3/ATF6B/ADCY9/TGFB1/GRB2/COL4A3/GNG10/ADCY5/AKT3/GNG2/GNAI2/SHC4/GNG8/MAP2K2/PRKCA/PRKACG/ADCY3/CREB3L1/GNG5/GNB1/SHC3/CREB3/MAPK8/VEGFB/ADCY6/PRKCZ/RELA/PIK3CB/SOS2/ADCY7/TGFBR1/COL1A1/HRAS/COL1A2/PIK3R3/SOS1/NRAS/GNG7/ARRB1/GNG12/PIK3R1/ATF4/CREB3L4/MAP2K1/MMP9/GNA15/GNB5/CREB3L2/PLCB1/SHC2/PIK3CA/COL4A2/ADCY8/ACTA2/PIK3CD/VEGFA/COL3A1/MAPK10/COL4A1/MAPK13/GNAI1/GNG11/CREB5/VEGFC/ADCY4/PLCB4/VEGFD/NFKB1/JUN/COL4A4/FOS/EDNRB/NFKBIA/EDN1	124
KEGG	hsa05135	Yersinia infection	131/6848	137/8135	2.374e-05	0.0001802	7.723e-05	FYB1/NLRP3/WAS/NLRC4/ARHGEF7/MAPK11/PTK2/CD8B/GIT2/IRF3/ROCK1/PTK2B/ARHGEF1/ZAP70/MAP2K7/MAPK12/MAPK1/ITGB1/AKT2/DOCK1/IFNB1/RAC3/PKN1/MAPK14/IL2/CD8A/ELMO2/BCAR1/MAPK3/SRC/ROCK2/TRAF6/MAPK9/VAV2/TAB1/AKT1/IKBKG/IKBKB/VAV1/PIP5K1C/CD4/PLCG1/LCK/RAC1/MAP2K4/WIPF2/RHOA/PIK3R2/FCGR2A/NFATC2/FN1/IRAK1/PIP5K1B/IRAK4/ACTB/MAP3K7/ITGA5/ARHGEF12/AKT3/MEFV/MAP2K2/ACTR3/ACTR3B/CRKL/CHUK/ARPC5/ARPC2/RPS6KA6/GNAQ/MAPK8/WIPF3/WASF2/RPS6KA1/TBK1/RELA/CRK/LAT/MYD88/IL10/PIK3CB/ACTG1/PXN/TRAF2/GSK3B/NFATC3/PIP5K1A/ACTR2/ARPC1A/RPS6KA2/PIK3R3/LIMK1/ACTR3C/IL18/ARPC1B/VAV3/PIK3R1/MAP2K1/ARPC3/BAIAP2/ARPC4/ARPC5L/TAB2/CDC42/RAC2/MAP2K6/TNF/PIK3CA/ARF6/SKAP2/PYCARD/PIK3CD/WIPF1/TICAM1/ITGA4/CASP1/ARHGEF28/MAPK10/WASL/RPS6KA3/MAPK13/MAP2K3/TLR4/ELMO1/NFATC1/NFKB1/CCL2/JUN/PKN2/FOS/CXCL8/NFKBIA	131
KEGG	hsa04110	Cell cycle	121/6848	126/8135	2.45e-05	0.0001818	7.793e-05	SKP1/FZR1/CDC14A/ANAPC11/SMAD4/ANAPC5/SMAD2/ZBTB17/YWHAE/SMC1A/ANAPC1/ANAPC2/TP53/CUL1/E2F2/YWHAQ/ANAPC7/CDK7/CDKN2A/CCNB3/RB1/PLK1/CDC25C/CDC16/ORC4/TFDP1/ANAPC15/ANAPC4/E2F1/E2F4/RBL1/CDK2/TGFB1/CDC27/PTTG2/ANAPC13/CCNH/ORC3/CDC26/CDK4/ORC2/MAD1L1/TGFB3/SFN/BUB3/YWHAG/YWHAB/ATM/CREBBP/MAD2L2/STAG1/RAD21/SMAD3/CCND3/HDAC1/ANAPC16/MDM2/ATR/PRKDC/ANAPC10/E2F3/GSK3B/CDKN2D/RBL2/MCM6/MCM7/CDKN1A/ORC5/EP300/SKP2/DBF4/HDAC2/E2F5/TFDP2/CDC25A/MCM4/BUB1/YWHAH/MYC/CCND2/PCNA/ABL1/CHEK2/ORC1/CDC23/CDC45/CCNE1/CDC25B/MCM5/MCM3/STAG2/SMC3/CCNA2/MCM2/SMC1B/CDC20/GADD45G/CDK1/CCNA1/CDC14B/ORC6/PTTG1/CDKN2C/CDK6/CDKN2B/CDC7/CCNB1/CCNB2/ESPL1/BUB1B/CCNE2/CCND1/MAD2L1/WEE1/TGFB2/TTK/CDKN1B/GADD45A/CDC6/CDKN1C/GADD45B	121
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	76/6848	77/8135	2.543e-05	0.0001832	7.852e-05	CACNG4/CACNG8/CTNNA3/DSC2/ACTN2/SGCB/CACNG2/RYR2/PKP2/CACNA1D/ITGB6/ACTN3/CACNG6/ITGB4/CACNG3/ATP2A1/ITGA2B/CTNNA1/ITGA9/SLC8A3/CACNA2D1/ITGB1/ATP2A3/CACNB1/CACNA1S/CACNG7/CACNG5/SLC8A2/DES/ATP2A2/ITGB7/ITGB3/ACTB/DAG1/CACNA2D4/ITGA5/CTNNA2/CACNA1F/CACNA2D2/CACNB2/EMD/ITGA11/LEF1/TCF7/SLC8A1/ACTG1/CACNB3/ITGAV/CACNA1C/GJA1/ITGA8/ITGA3/LMNA/SGCA/CACNB4/ITGA7/ITGB5/TCF7L1/SGCD/ITGA4/LAMA1/ITGA1/DMD/JUP/ITGB8/ITGA10/ITGA6/DSP/TCF7L2/CACNA2D3/CDH2/DSG2/LAMA2/SGCG/ITGA2/CTNNB1	76
KEGG	hsa04390	Hippo signaling pathway	149/6848	157/8135	2.578e-05	0.0001832	7.852e-05	TP73/CTNNA3/BMP7/PPP2R2D/RASSF6/BMP8B/BMP8A/PPP2R2C/WNT10A/PPP2R1A/CRB1/SOX2/SMAD4/SMAD2/LLGL1/YWHAE/WNT16/FBXW11/CTNNA1/WNT2B/PATJ/FRMD1/DLG4/YAP1/WNT3/CDH1/WNT6/WNT10B/YWHAQ/CSNK1D/APC2/LLGL2/BTRC/WNT8B/WNT1/PPP1CC/AXIN1/CRB2/LATS1/PARD6A/TEAD2/FZD9/WNT7B/WNT7A/DLG2/PARD6G/PPP1CB/TGFBR2/DLG3/CSNK1E/FZD3/PPP2CB/AXIN2/TGFB1/DVL3/NF2/BMP5/TEAD3/ACTB/PPP2R1B/DVL1/PARD6B/CTNNA2/WNT8A/MPP5/PPP1CA/FZD1/WWC1/PPP2R2A/APC/WNT9B/DVL2/LIMD1/TGFB3/YWHAG/DLG5/DLG1/YWHAB/LEF1/SCRIB/PRKCZ/TCF7/SMAD3/CCND3/WNT11/ACTG1/TEAD4/TGFBR1/WNT9A/PARD3/MOB1A/GSK3B/PPP2CA/WNT5B/BMPR1A/WTIP/AREG/BBC3/BIRC2/AFP/PRKCI/MOB1B/YWHAH/MYC/PPP2R2B/CCND2/FZD8/NKD2/FGF1/FZD4/TP53BP2/RASSF1/TCF7L1/GLI2/AMOT/WWTR1/FZD5/SMAD1/BIRC5/STK3/LATS2/FZD6/SNAI2/GDF5/SERPINE1/BMPR1B/AJUBA/FRMD6/FZD2/BMPR2/TCF7L2/CCND1/BMP4/ID2/BMP6/WNT4/ITGB2/TGFB2/TEAD1/SAV1/WNT5A/NKD1/CCN2/SMAD7/ID1/FZD7/WNT2/BMP2/CTNNB1	149
KEGG	hsa05410	Hypertrophic cardiomyopathy	88/6848	90/8135	2.759e-05	0.000192	8.23e-05	CACNG4/CACNG8/TTN/MYH6/SGCB/CACNG2/RYR2/CACNA1D/ITGB6/MYBPC3/TNNT2/CACNG6/ITGB4/CACNG3/ATP2A1/ITGA2B/TNNI3/ITGA9/SLC8A3/CACNA2D1/ITGB1/PRKAA1/ATP2A3/TNNC1/CACNB1/MYL2/CACNA1S/CACNG7/CACNG5/PRKAG1/SLC8A2/DES/ATP2A2/ACE/ITGB7/ITGB3/TGFB1/ACTB/PRKAB1/DAG1/CACNA2D4/ITGA5/PRKAA2/TPM4/CACNA1F/MYL3/CACNA2D2/TGFB3/CACNB2/EMD/ITGA11/MYH7/TPM2/PRKAG3/SLC8A1/ACTG1/TPM3/CACNB3/PRKAG2/ITGAV/PRKAB2/CACNA1C/ITGA8/ITGA3/LMNA/TPM1/SGCA/CACNB4/ITGA7/TNF/ITGB5/SGCD/ITGA4/LAMA1/ITGA1/DMD/ITGB8/ITGA10/ITGA6/CACNA2D3/ACTC1/TGFB2/LAMA2/SGCG/ITGA2/AGT/IGF1/EDN1	88
KEGG	hsa04150	mTOR signaling pathway	148/6848	156/8135	2.92e-05	0.0001958	8.391e-05	STK11/ATP6V1C2/WNT10A/LAMTOR3/PRKCG/PRKCB/AKT1S1/ATP6V1F/RPS6/WNT16/TSC2/INS/RPS6KB1/WNT2B/ATP6V1B1/MAPK1/WNT3/AKT2/WNT6/WNT10B/EIF4E2/PRKAA1/NPRL3/LPIN3/KRAS/WNT8B/LAMTOR5/TNFRSF1A/PDPK1/RNF152/MAPK3/ATP6V1G3/WNT1/RHEB/RAF1/MLST8/AKT1/ATP6V1D/STRADA/FZD9/IKBKB/WNT7B/ATP6V1E1/WNT7A/FLCN/RRAGA/LPIN2/LAMTOR2/RHOA/RPS6KB2/PIK3R2/FZD3/CAB39L/DVL3/LAMTOR1/GRB2/RRAGC/PRKAA2/DVL1/MAPKAP1/AKT3/WNT8A/WDR59/FZD1/BRAF/MAP2K2/WDR24/PTEN/PRKCA/CAB39/WNT9B/RPTOR/TELO2/NPRL2/DEPDC5/ATP6V1G2/DVL2/CHUK/ATP6V1E2/CLIP1/RPS6KA6/RPS6KA1/TBC1D7/ATP6V1C1/TSC1/WNT11/PIK3CB/SOS2/RICTOR/ATP6V1A/EIF4B/WNT9A/ATP6V1G1/LPIN1/GSK3B/MIOS/SLC38A9/ATP6V1H/HRAS/SEC13/RPS6KA2/ATP6V1B2/PIK3R3/WNT5B/SOS1/NRAS/PIK3R1/SKP2/PRR5L/MAP2K1/LRP5/MTOR/SLC3A2/SEH1L/LAMTOR4/STRADB/TNF/EIF4E/GRB10/FZD8/PIK3CA/IGF1R/FZD4/PIK3CD/PRR5/ULK2/FZD5/SESN2/FZD6/LRP6/INSR/EIF4EBP1/DEPTOR/RPS6KA3/SGK1/FZD2/ULK1/RRAGB/WNT4/RRAGD/FNIP2/SLC7A5/IRS1/WNT5A/DDIT4/IGF1/FZD7/WNT2	148
KEGG	hsa04971	Gastric acid secretion	75/6848	76/8135	2.989e-05	0.0001958	8.391e-05	KCNJ16/PLCB2/CFTR/ATP1A4/KCNJ1/PRKCG/PRKCB/CAMK2B/SLC4A2/SLC26A7/PRKACB/KCNJ10/GNAS/KCNK10/ATP1A2/CCKBR/ATP1B4/PRKACA/ATP1B2/ATP4B/CALML4/KCNQ1/MYLK4/GNAI3/ATP1A1/CALM2/CHRM3/MYLK2/MYLK3/ADCY2/HRH2/ADCY1/ATP1B3/SST/CALML6/PLCB3/CA2/ADCY9/ATP1A3/CALM3/SLC9A1/GAST/ACTB/ADCY5/GNAI2/PRKCA/CALML3/PRKACG/ADCY3/SSTR2/ATP4A/ITPR2/CALML5/GNAQ/CAMK2A/ADCY6/ACTG1/ADCY7/ITPR3/CAMK2G/KCNE2/CALM1/PLCB1/CAMK2D/ADCY8/ITPR1/EZR/KCNK2/MYLK/GNAI1/ADCY4/PLCB4/KCNJ15/ATP1B1/KCNJ2	75
KEGG	hsa05220	Chronic myeloid leukemia	75/6848	76/8135	2.989e-05	0.0001958	8.391e-05	PTPN11/POLK/SMAD4/TP53/ARAF/MAPK1/E2F2/AKT2/BCL2L1/KRAS/BAD/CDKN2A/MAPK3/RB1/CBL/RUNX1/RAF1/AKT1/IKBKG/IKBKB/SHC1/E2F1/PIK3R2/TGFBR2/TGFB1/GRB2/CTBP1/AKT3/BRAF/BCR/SHC4/MAP2K2/STAT5B/CRKL/CDK4/CHUK/TGFB3/SHC3/CTBP2/RELA/SMAD3/CRK/HDAC1/MDM2/PIK3CB/SOS2/E2F3/TGFBR1/HRAS/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/HDAC2/MAP2K1/BAX/MYC/BAK1/SHC2/ABL1/PIK3CA/PIK3CD/GADD45G/CDK6/GAB2/MECOM/CCND1/DDB2/TGFB2/CDKN1B/GADD45A/NFKB1/GADD45B/NFKBIA	75
KEGG	hsa04916	Melanogenesis	98/6848	101/8135	3.367e-05	0.0002162	9.268e-05	GNAO1/PLCB2/WNT10A/PRKCG/PRKCB/DCT/TYR/CAMK2B/PRKACB/WNT16/GNAS/PRKACA/WNT2B/CREB3L3/MAPK1/POMC/WNT3/CALML4/TYRP1/WNT6/WNT10B/KRAS/CREB1/WNT8B/GNAI3/MAPK3/WNT1/RAF1/CALM2/FZD9/WNT7B/WNT7A/ADCY2/ADCY1/CALML6/FZD3/PLCB3/ADCY9/CALM3/DVL3/ADCY5/DVL1/WNT8A/GNAI2/FZD1/MAP2K2/ASIP/PRKCA/CALML3/MC1R/PRKACG/WNT9B/ADCY3/CREB3L1/DVL2/CALML5/GNAQ/CREB3/CREBBP/KITLG/LEF1/CAMK2A/ADCY6/TCF7/WNT11/ADCY7/WNT9A/GSK3B/HRAS/CAMK2G/WNT5B/NRAS/EP300/CALM1/CREB3L4/MAP2K1/CREB3L2/PLCB1/FZD8/FZD4/CAMK2D/ADCY8/TCF7L1/FZD5/FZD6/GNAI1/FZD2/ADCY4/PLCB4/TCF7L2/WNT4/MITF/WNT5A/FZD7/EDNRB/WNT2/CTNNB1/EDN1	98
KEGG	hsa04921	Oxytocin signaling pathway	146/6848	154/8135	3.744e-05	0.000236	0.0001011	TRPM2/CACNG4/CACNG8/GNAO1/KCNJ5/PLCB2/CAMK1G/RYR3/CACNG2/RYR2/CACNA1D/PPP3CB/PRKCG/CACNG6/PRKCB/CAMK2B/PRKACB/KCNJ3/NPPA/ROCK1/PPP3R2/CACNG3/KCNJ4/GNAS/CAMK4/PIK3R5/PIK3CG/PRKACA/MAPK1/CACNA2D1/PLA2G4F/CALML4/NOS3/PRKAA1/PPP1R12B/KRAS/NPR1/EGFR/MYLK4/CACNB1/GNAI3/MAPK3/SRC/ROCK2/PPP1CC/RAF1/CACNA1S/CALM2/CACNG7/PIK3R6/CACNG5/PRKAG1/ELK1/CAMKK2/MYLK2/MYLK3/MYL6/ADCY2/RHOA/ADCY1/PPP1CB/CALML6/RYR1/PLCB3/KCNJ9/NFATC2/ADCY9/CALM3/EEF2/OXT/ACTB/PRKAB1/CACNA2D4/ADCY5/PRKAA2/PPP1CA/CACNA1F/GNAI2/PPP1R12C/MAP2K2/PRKCA/CALML3/PRKACG/ADCY3/CAMK1/CACNA2D2/ITPR2/GUCY1A1/CALML5/GNAQ/CACNB2/CAMK2A/ADCY6/PRKAG3/KCNJ14/MAPK7/ACTG1/ADCY7/ITPR3/PLA2G4C/MYL6B/MEF2C/PPP3CA/CACNB3/NFATC3/HRAS/CAMK2G/MYL9/PRKAG2/PRKAB2/PPP1R12A/CACNA1C/NRAS/CDKN1A/CALM1/NFATC4/KCNJ12/MAP2K1/GUCY1B1/NPR2/CACNB4/PLCB1/CAMK2D/ADCY8/CAMK1D/EEF2K/ITPR1/CD38/RCAN1/GUCY1A2/MAP2K5/MYLK/GNAI1/KCNJ6/ADCY4/PLCB4/CCND1/CACNA2D3/RGS2/NFATC1/PPP3R1/JUN/OXTR/KCNJ2/FOS/PLA2G4A	146
KEGG	hsa05213	Endometrial cancer	58/6848	58/8135	4.419e-05	0.0002733	0.0001171	CTNNA3/POLK/ERBB2/CTNNA1/TP53/ARAF/MAPK1/AKT2/CDH1/ILK/KRAS/APC2/BAD/EGFR/PDPK1/EGF/MAPK3/AXIN1/RAF1/AKT1/ELK1/PIK3R2/AXIN2/GRB2/AKT3/CTNNA2/BRAF/MAP2K2/PTEN/APC/CASP9/MLH1/LEF1/TCF7/PIK3CB/SOS2/GSK3B/HRAS/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/FOXO3/MAP2K1/BAX/MYC/BAK1/PIK3CA/TCF7L1/PIK3CD/GADD45G/TCF7L2/CCND1/DDB2/GADD45A/GADD45B/CTNNB1	58
KEGG	hsa04142	Lysosome	126/6848	132/8135	4.575e-05	0.0002778	0.0001191	HGSNAT/HYAL4/AP1B1/ABCB9/SPAM1/ATP6V0C/CLTC/SLC11A1/ATP6V0A1/ATP6V0D2/LAMP1/CD63/AP1M2/LAPTM4A/CTSE/PSAP/ATP6V0D1/CD164/HYAL2/CTSW/ATP6V0A4/GNPTG/AP1M1/GGA1/ABCA2/DNASE2B/AP3S1/PSAPL1/IDUA/CLTA/AP1G2/AP4E1/ATP6AP1/IDS/AP1G1/NAPSA/CTSV/LAPTM5/GM2A/MCOLN1/SCARB2/PPT1/AP3M1/AP3B1/SMPD1/CTNS/GNS/AP3B2/CTSG/GLB1/CLTCL1/TCIRG1/NEU1/LAMP3/TPP1/AP4S1/NAGA/SGSH/HYAL3/ACP2/ASAH1/LAPTM4B/HEXB/CTSK/FUCA2/MFSD8/GGA3/AP3S2/GUSB/CLN5/HEXA/NAGLU/NAGPA/MAN2B1/AP4M1/GAA/CTSA/GALC/ACP5/M6PR/GLA/AP1S3/ATP6V1H/PLA2G15/MANBA/LAMP2/AP1S2/DMXL1/CTSL/AP4B1/ATP6V0B/AGA/ATP6V0A2/CTSO/ENTPD4/LGMN/SUMF1/CLN3/GALNS/WDR7/GNPTAB/SLC17A5/AP1S1/SORT1/LIPA/DNASE2/AP3M2/CTSF/ARSB/CD68/NPC1/NPC2/FUCA1/HYAL1/ARSG/LITAF/CTSH/ARSA/DMXL2/AP3D1/SLC11A2/NCOA7/IGF2R/CTSS/CTSZ/CTSC	126
KEGG	hsa05161	Hepatitis B	153/6848	162/8135	4.708e-05	0.0002808	0.0001204	ATF2/JAK3/FASLG/MAPK11/PRKCG/PRKCB/SMAD4/IRF3/PTK2B/DDX3X/TP53/SLC10A1/BCL2/MAP2K7/MAPK12/CREB3L3/ARAF/IFNA6/MAPK1/STAT6/E2F2/TIRAP/AKT2/CASP10/IFNB1/YWHAQ/KRAS/MAPK14/CREB1/BAD/IFNA2/VDAC3/MAPK3/SRC/RB1/TRAF6/MAPK9/IFNA5/RAF1/TAB1/AKT1/ELK1/IKBKG/IKBKB/ATP6AP1/MAP2K4/E2F1/TYK2/PIK3R2/TGFBR2/NFATC2/ATF6B/IFNA1/CDK2/IRAK1/TGFB1/IRAK4/CASP8/GRB2/MAP3K7/IFNA14/AKT3/DDB1/BRAF/MAP2K2/PRKCA/CREB3L1/STAT5B/IFNA16/CHUK/TGFB3/CASP9/IFNA8/CREB3/MAPK8/YWHAB/CREBBP/HSPG2/TBK1/MAVS/RELA/SMAD3/MYD88/STAT3/PIK3CB/CASP3/SOS2/JAK1/APAF1/E2F3/TGFBR1/MAP3K1/IKBKE/NFATC3/HRAS/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/EP300/ATF4/NFATC4/CREB3L4/MAP2K1/BAX/FADD/MMP9/TAB2/TICAM2/STAT2/CREB3L2/MYC/MAP2K6/IFNAR1/TNF/PCNA/PIK3CA/CCNE1/PIK3CD/CYCS/FAS/TLR3/TICAM1/TLR2/TRAF3/CCNA2/BIRC5/STAT1/IFNA21/CCNA1/MAPK10/IRF7/MAPK13/JAK2/CREB5/MAP2K3/TLR4/DDX58/CCNE2/DDB2/TGFB2/IFIH1/NFATC1/NFKB1/JUN/BID/STAT4/EGR3/FOS/CXCL8/EGR2/NFKBIA	153
KEGG	hsa05223	Non-small cell lung cancer	71/6848	72/8135	5.696e-05	0.0003338	0.0001431	JAK3/POLK/TGFA/PRKCG/PRKCB/KIF5A/ALK/ERBB2/TP53/RET/ARAF/MAPK1/E2F2/AKT2/RXRB/KRAS/BAD/CDKN2A/EGFR/PDPK1/EGF/PLCG2/MAPK3/RB1/RAF1/KIF5B/RXRG/RARB/AKT1/PLCG1/E2F1/PIK3R2/RXRA/GRB2/STK4/AKT3/BRAF/MAP2K2/PRKCA/STAT5B/CDK4/CASP9/STAT3/PIK3CB/SOS2/KIF5C/E2F3/FHIT/HRAS/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/FOXO3/MAP2K1/BAX/EML4/MET/BAK1/PIK3CA/RASSF1/PIK3CD/HGF/GADD45G/CDK6/CCND1/DDB2/GADD45A/RASSF5/GADD45B	71
KEGG	hsa04070	Phosphatidylinositol signaling system	94/6848	97/8135	6.018e-05	0.0003431	0.0001471	OCRL/PLCB2/DGKB/DGKZ/PRKCG/PRKCB/MTMR8/INPP5D/DGKE/MTMR7/CALML4/DGKA/IP6K3/PIKFYVE/PIK3C2A/INPP5B/PIP4K2B/PLCG2/CALM2/PLCZ1/CDS2/INPP4A/DGKG/ITPK1/PI4KB/PLCD1/PIP5K1C/PLCG1/PIK3C2G/DGKQ/MTMR2/PI4K2A/PIK3R2/CALML6/PIK3C3/PLCB3/MTMR14/PIP5K1B/MTMR1/CALM3/MTMR6/INPP5E/MTMR3/CDIPT/PTEN/PRKCA/CALML3/DGKH/INPP5A/IP6K2/IP6K1/PIP4K2A/INPP5F/ITPR2/CALML5/INPP1/PLCD3/SACM1L/IMPAD1/IPMK/ITPKA/INPPL1/DGKD/PPIP5K2/MTM1/IMPA1/PIK3CB/ITPR3/PIP5K1A/IPPK/PIK3R3/PIP4K2C/PIK3R1/PIP4P1/CALM1/PLCD4/PIP4P2/PI4K2B/ITPKB/PLCB1/CDS1/PIK3CA/SYNJ1/ITPKC/PIK3CD/ITPR1/PIK3C2B/MTMR4/SYNJ2/IMPA2/PLCE1/INPP4B/PLCB4/DGKI	94
KEGG	hsa04144	Endocytosis	232/6848	251/8135	6.061e-05	0.0003431	0.0001471	AP2A1/EPN3/SH3GLB2/SNX6/EPN1/GRK6/ARFGAP2/CLTC/RAB11B/IQSEC2/AP2M1/IL2RG/ARRB2/CYTH4/GIT2/SMAD2/DNM2/IL2RA/ACAP1/SNX3/AP2A2/ARFGEF2/RBSN/KIF5A/PDCD6IP/VPS29/VPS35/RAB5C/IQSEC3/AGAP2/FOLR2/PDGFRA/WWP1/MVB12B/PSD/STAM2/CCR5/VPS4A/RAB11A/HSPA6/RAB11FIP3/GRK1/TSG101/RAB5A/CAPZA3/EGFR/ARFGEF1/SNX32/DNM3/GRK2/RAB8A/SRC/STAMBP/TRAF6/EHD2/CBL/CHMP1A/KIF5B/CLTA/CHMP4C/PARD6A/SH3GL3/CHMP2A/FGFR3/CHMP3/AP2S1/SMAP1/VPS37C/IL2RB/CXCR2/PIP5K1C/PSD4/RAB7A/VPS45/AP2B1/RUFY2/WIPF2/CAV3/PLD2/TFRC/RHOA/ZFYVE27/RAB5B/HGS/GRK4/AGAP3/PARD6G/SNX12/ACAP3/RAB11FIP5/PIP5KL1/TGFBR2/EPS15L1/SNX1/IST1/SH3GL2/SNF8/CAPZB/ARF1/CHMP2B/PIP5K1B/RAB35/RAB22A/GRK7/RAB11FIP4/CHMP4A/SNX5/CBLC/VPS28/VPS26B/FOLR1/GIT1/GRK3/CHMP6/ZFYVE9/WASHC5/VPS26A/CLTCL1/PARD6B/VTA1/ARF3/SH3GL1/CYTH1/CYTH3/CAPZA1/PML/SNX4/SH3GLB1/RABEP1/ACTR3/SMURF1/CHMP7/ACTR3B/RNF41/CAPZA2/RAB4A/ARF5/RUFY1/EPN2/VPS36/ARFGAP1/WASHC4/ARPC5/VPS37D/ARF4/ARPC2/HLA-G/VPS4B/WIPF3/MVB12A/CYTH2/CHMP5/PRKCZ/ARAP3/AGAP1/ACAP2/BIN1/SMAD3/EHD4/IQSEC1/USP8/GBF1/MDM2/SPG21/EEA1/CXCR1/KIF5C/SPART/CHMP4B/DAB2/FGFR2/SH3KBP1/TGFBR1/PARD3/PIP5K1A/ACTR2/HRAS/ARPC1A/ZFYVE16/ACTR3C/VPS37B/ARPC1B/HSPA1A/ARRB1/FOLR3/EPS15/ARAP1/LDLRAP1/VPS37A/ARPC3/CXCR4/ARPC4/ARPC5L/RAB31/WASHC3/HLA-F/PRKCI/RAB10/EHD3/ASAP1/CDC42/ARFGAP3/CAV1/ASAP2/DNM1/ARF6/IGF1R/PSD3/RAB11FIP2/CAV2/WIPF1/HSPA1L/GRK5/HLA-E/CHMP1B/NEDD4/WASL/RAB11FIP1/LDLR/EHD1/ITCH/PLD1/CBLB/SMAP2/ASAP3/ARAP2/DNAJC6/AMPH/SMURF2/HSPA2/NEDD4L/IGF2R	232
KEGG	hsa04014	Ras signaling pathway	215/6848	232/8135	7.067e-05	0.0003934	0.0001686	GRIN1/PTPN11/AFDN/PAK5/GNGT1/PAK4/PDGFB/EFNA2/GNG4/FASLG/TGFA/PRKCG/PRKCB/RASGRF1/FGF17/PLA2G12B/PRKACB/RAP1A/PAK6/PLA2G2D/INS/RAB5C/ZAP70/FGF21/PRKACA/FGF23/PDGFRA/EFNA3/MAPK1/PLA2G10/PLA2G4F/CALML4/NF1/AKT2/SYNGAP1/ANGPT4/BCL2L1/GRIN2B/RAPGEF5/RASAL1/RAC3/RASGRP4/RAB5A/KRAS/BAD/ANGPT2/RASAL3/EGFR/EGF/PLCG2/GNG13/MAPK3/PLA2G2F/MAPK9/KSR1/FGF3/GNG3/RAF1/CALM2/PAK2/RASGRP3/FGF6/FGF20/FGFR3/AKT1/ELK1/GNB4/IKBKG/IKBKB/CSF1R/HTR7/PLA2G6/PLCG1/PLA2G3/NTRK1/RAC1/FGF16/PLD2/RHOA/SHC1/RAB5B/SHOC2/KSR2/PIK3R2/GNB2/CALML6/FGF4/GNGT2/RASA3/CALM3/FGF8/PLA2G1B/GRB2/STK4/GNG10/FOXO4/AKT3/FLT3/GNG2/RASA1/SHC4/EXOC2/GNG8/MAP2K2/PRKCA/CALML3/PRKACG/GNG5/RALB/GNB1/BRAP/CHUK/SHC3/FGF22/CALML5/RASGRP2/MAPK8/CSF1/TBK1/KITLG/RIN1/VEGFB/RELA/RRAS/LAT/RAP1B/FLT3LG/PIK3CB/MRAS/SOS2/PLA2G12A/RRAS2/FGFR2/PLA2G4C/HRAS/PAK1/PIK3R3/SOS1/GRIN2A/RGL2/NRAS/GNG7/GNG12/PDGFRB/PIK3R1/CALM1/RASGRF2/MAP2K1/KDR/NTRK2/RALGDS/RASAL2/PDGFC/RALBP1/TEK/CDC42/RAC2/GNB5/EFNA4/MET/PAK3/SHC2/PLA2G5/ABL1/PIK3CA/ARF6/IGF1R/FGF1/ANGPT1/PLA1A/RASSF1/PIK3CD/RALA/PDGFD/IGF2/VEGFA/FLT1/FGF7/HGF/ETS2/INSR/GAB1/MAPK10/ABL2/NTF3/PLD1/ETS1/GNG11/VEGFC/PGF/EFNA5/GAB2/PLCE1/TIAM1/BDNF/PLAAT3/VEGFD/EPHA2/RASA2/RGL1/RASA4/NGF/FGF5/PLA2G2A/RASSF5/EFNA1/PDGFA/FGF2/NFKB1/FGF18/FGF9/IGF1/RASGRP1/PLA2G4A/FGF10	215
KEGG	hsa04072	Phospholipase D signaling pathway	140/6848	148/8135	7.826e-05	0.0004285	0.0001837	GRM8/SYK/PTPN11/AVP/PLCB2/GNA13/GRM5/DGKB/AVPR2/GRM1/PDGFB/GRM7/F2/LPAR5/DGKZ/CYTH4/DGKE/AVPR1A/FCER1A/DNM2/GRM2/PTK2B/LPAR2/GNAS/PIK3R5/PIK3CG/TSC2/INS/PDGFRA/GRM3/MS4A2/GRM4/MAPK1/AGPAT1/PLA2G4F/AKT2/DGKA/LPAR3/RAPGEF3/KRAS/EGFR/EGF/PLCG2/DNM3/MAPK3/RHEB/RAF1/PIK3R6/AVPR1B/AKT1/DGKG/CXCR2/PIP5K1C/PLCG1/PLD2/ADCY2/RHOA/SHC1/DGKQ/ADCY1/PIK3R2/GNA12/PLCB3/ARF1/AGPAT2/ADCY9/PIP5K1B/SPHK2/GRB2/ADCY5/AKT3/CYTH1/CYTH3/SHC4/MAP2K2/PRKCA/DGKH/FCER1G/ADCY3/RALB/AGPAT3/GRM6/SHC3/CYTH2/KITLG/ADCY6/PLPP2/RRAS/TSC1/DGKD/PIK3CB/CXCR1/MRAS/SOS2/ADCY7/RRAS2/PLA2G4C/PIP5K1A/HRAS/PIK3R3/PLPP3/SOS1/NRAS/PDGFRB/PIK3R1/LPAR1/MAP2K1/RALGDS/PDGFC/LPAR4/MTOR/PLCB1/SHC2/DNM1/PIK3CA/ARF6/ADCY8/RAPGEF4/PLPP1/PIK3CD/FYN/RALA/PDGFD/PTGFR/INSR/GAB1/AGPAT5/AGPAT4/PLD1/GAB2/LPAR6/ADCY4/PLCB4/SPHK1/PDGFA/DGKI/AGT/AGTR1/CXCL8/PLA2G4A	140
KEGG	hsa04310	Wnt signaling pathway	157/6848	167/8135	8.127e-05	0.0004378	0.0001877	SKP1/SFRP5/PLCB2/WNT10A/PPP3CB/PRKCG/PRKCB/TLE6/CAMK2B/SMAD4/CXXC4/PRKACB/PPP3R2/WNT16/FBXW11/TP53/NOTUM/CUL1/PRKACA/WNT2B/SOST/WNT3/SENP2/WNT6/WNT10B/RAC3/CTNNBIP1/PRICKLE3/APC2/CSNK2B/BTRC/WNT8B/CTNND2/CSNK2A1/ROCK2/WNT1/MAPK9/TBL1Y/DKK4/AXIN1/CSNK1A1/DKK2/FZD9/CHD8/WNT7B/WNT7A/MMP7/VANGL1/RAC1/RHOA/INVS/CSNK1E/FZD3/PLCB3/RSPO4/NFATC2/AXIN2/CSNK2A2/PSEN1/DVL3/CBY1/CTBP1/MAP3K7/DVL1/LGR6/WNT8A/CER1/RYK/FZD1/PRKCA/WIF1/APC/PRKACG/WNT9B/DVL2/RSPO1/CTBP2/PORCN/MAPK8/CREBBP/LEF1/CAMK2A/TCF7/SMAD3/CCND3/WNT11/CACYBP/VANGL2/CCN4/WNT9A/PPP3CA/TBL1X/GSK3B/NFATC3/CAMK2G/TLE4/TLE3/WNT5B/RUVBL1/EP300/NFATC4/LRP5/FRZB/TLE2/RAC2/SOX17/ROR1/MYC/PLCB1/SIAH1/PPARD/CCND2/FZD8/LGR4/NKD2/FZD4/CAMK2D/SERPINF1/TLE1/TCF7L1/NLK/FZD5/FZD6/LRP6/RSPO2/MAPK10/PRICKLE2/ROR2/FOSL1/GPC4/TBL1XR1/SFRP4/FZD2/PLCB4/TCF7L2/CCND1/ZNRF3/FRAT2/PRICKLE1/WNT4/DKK1/LGR5/FRAT1/BAMBI/DAAM2/WNT5A/NKD1/DAAM1/NFATC1/PPP3R1/SFRP1/JUN/FZD7/RSPO3/SFRP2/WNT2/CTNNB1	157
KEGG	hsa05224	Breast cancer	139/6848	147/8135	8.838e-05	0.0004686	0.0002008	ESR1/NOTCH3/TNFSF11/WNT10A/POLK/ESR2/DLL1/FGF17/WNT16/ERBB2/TP53/RPS6KB1/FGF21/WNT2B/FGF23/ARAF/MAPK1/E2F2/WNT3/AKT2/WNT6/WNT10B/KRAS/APC2/HEYL/WNT8B/EGFR/EGF/MAPK3/DLL3/RB1/WNT1/AXIN1/CSNK1A1/FGF3/RAF1/FGF6/SP1/FGF20/AKT1/FZD9/WNT7B/WNT7A/FGF16/SHC1/E2F1/RPS6KB2/PIK3R2/FGF4/FZD3/AXIN2/DVL3/FGF8/GRB2/DVL1/AKT3/WNT8A/FZD1/BRAF/SHC4/MAP2K2/PTEN/APC/WNT9B/JAG2/CDK4/DVL2/SHC3/FGF22/LEF1/HES5/TCF7/PGR/NOTCH2/NOTCH4/WNT11/PIK3CB/NOTCH1/BRCA1/SOS2/E2F3/WNT9A/HEY2/GSK3B/HRAS/BRCA2/PIK3R3/WNT5B/SOS1/NCOA1/NRAS/CDKN1A/PIK3R1/MAP2K1/LRP5/BAX/MTOR/NFKB2/MYC/BAK1/SHC2/NCOA3/FZD8/PIK3CA/IGF1R/FGF1/FZD4/TCF7L1/PIK3CD/FZD5/FGF7/FZD6/GADD45G/LRP6/CDK6/HEY1/FZD2/JAG1/TCF7L2/CCND1/FRAT2/DDB2/FGF5/WNT4/GADD45A/FRAT1/WNT5A/FGF2/FGF18/FGF9/JUN/IGF1/FOS/GADD45B/FZD7/HES1/WNT2/CTNNB1/FGF10	139
KEGG	hsa04920	Adipocytokine signaling pathway	68/6848	69/8135	9.219e-05	0.0004811	0.0002062	PTPN11/PCK1/STK11/ACSBG1/SLC2A4/POMC/AKT2/IRS4/ACSL6/RXRB/PRKAA1/TNFRSF1A/MAPK9/G6PC2/RXRG/ADIPOQ/PRKAG1/AKT1/IKBKG/CAMKK2/IKBKB/G6PC/TRADD/PRKCQ/ACSBG2/CPT1A/RXRA/ADIPOR1/AGRP/G6PC3/PRKAB1/PRKAA2/AKT3/CHUK/MAPK8/ADIPOR2/RELA/PRKAG3/STAT3/CPT1C/NFKBIB/NPY/TRAF2/PPARA/LEP/PRKAG2/PRKAB2/ACACB/CPT1B/MTOR/PCK2/TNF/ACSL1/LEPR/MAPK10/ACSL5/JAK2/SOCS3/ACSL3/IRS1/PPARGC1A/NFKB1/TNFRSF1B/CD36/NFKBIE/SLC2A1/IRS2/NFKBIA	68
KEGG	hsa04218	Cellular senescence	147/6848	156/8135	9.627e-05	0.0004947	0.000212	GATA4/HIPK1/MAPK11/CACNA1D/PPP3CB/SLC25A31/SMAD2/PPP3R2/FBXW11/RAD9B/TP53/TSC2/MAPK12/MAPK1/E2F2/CALML4/AKT2/MYBL2/KRAS/MAPK14/BTRC/CDKN2A/CCNB3/VDAC3/HIPK4/MAPK3/RB1/PPP1CC/RHEB/RAF1/CALM2/AKT1/VDAC2/SLC25A6/E2F1/CAPN1/MRE11/ZFP36L1/PIK3R2/PPP1CB/TGFBR2/CALML6/E2F4/RBL1/NFATC2/HUS1/CDK2/TGFB1/MAPKAPK2/CALM3/RBBP4/AKT3/LIN9/PPP1CA/TRPV4/MAP2K2/PTEN/CAPN2/CALML3/HIPK3/SLC25A5/CDK4/TGFB3/ITPR2/HLA-G/RAD50/CALML5/ATM/RELA/RRAS/SMAD3/TRPM7/CCND3/TSC1/MDM2/SLC25A4/PIK3CB/MRAS/LIN54/ATR/RRAS2/LIN37/PPID/E2F3/TGFBR1/ITPR3/PPP3CA/NFATC3/HRAS/RBL2/PIK3R3/NRAS/CDKN1A/PIK3R1/CALM1/FOXO3/NFATC4/RAD9A/MAP2K1/E2F5/MCU/LIN52/VDAC1/CDC25A/ZFP36L2/MTOR/HLA-F/MYC/MAP2K6/TRAF3IP2/CCND2/PIK3CA/CHEK2/IGFBP3/CCNE1/HIPK2/RAD1/SIRT1/PIK3CD/ITPR1/HLA-E/FOXM1/CCNA2/GADD45G/CDK1/CCNA1/EIF4EBP1/SERPINE1/FOXO1/NBN/CDK6/CDKN2B/MAPK13/ETS1/CCNB1/CCNB2/MAP2K3/CCNE2/CCND1/TGFB2/GADD45A/RASSF5/NFATC1/NFKB1/PPP3R1/GADD45B/CXCL8	147
KEGG	hsa04062	Chemokine signaling pathway	179/6848	192/8135	0.0001111	0.0005622	0.000241	CXCR3/PLCB2/WAS/GNGT1/CXCR6/JAK3/GRK6/GNG4/PTK2/CCL23/ARRB2/PRKCB/CCL15/XCL1/CCL25/PRKACB/CCL24/ROCK1/CCR2/PTK2B/RAP1A/PIK3R5/PIK3CG/PRKACA/MAPK1/CXCR5/CCR5/AKT2/FGR/RAC3/GRK1/GSK3A/KRAS/BAD/CXCL13/ITK/PLCG2/GRK2/GNG13/CCL21/GNAI3/BCAR1/MAPK3/SRC/ROCK2/VAV2/GNG3/RAF1/PIK3R6/CCR9/CCR3/AKT1/GNB4/IKBKG/IKBKB/VAV1/CCL16/CXCR2/PLCG1/XCR1/PPBP/RAC1/ADCY2/RHOA/SHC1/GRK4/ADCY1/PIK3R2/GNB2/CCL17/CCR8/GNGT2/PLCB3/ADCY9/GRB2/GRK7/GRK3/GNG10/CCL22/ADCY5/AKT3/CX3CR1/GNG2/DOCK2/CCR6/CCR4/NCF1/GNAI2/CCL27/CCL19/BRAF/SHC4/GNG8/PRKACG/ADCY3/STAT5B/GNG5/CRKL/GNB1/CHUK/SHC3/CCL28/GNAQ/RASGRP2/ADCY6/PRKCZ/RELA/CRK/CCL18/CXCL9/RAP1B/STAT3/PIK3CB/CXCR1/NFKBIB/SOS2/ADCY7/CCL1/CCR10/CCR7/PARD3/PXN/GSK3B/HRAS/PAK1/PIK3R3/VAV3/SOS1/NRAS/GNG7/ARRB1/GNG12/PF4/PIK3R1/FOXO3/MAP2K1/CXCR4/CDC42/RAC2/GNB5/STAT2/PLCB1/SHC2/PF4V1/PIK3CA/ADCY8/PIK3CD/PRKCD/CCL26/GRK5/CCR1/STAT1/CXCL12/GNAI1/JAK2/GNG11/TIAM1/PREX1/ADCY4/PLCB4/ELMO1/CXCL16/CCL13/HCK/CXCL14/CCL4/CCL11/NFKB1/CCL2/CCL20/CX3CL1/LYN/CXCL1/CXCL3/CXCL8/CXCL2/CCL5/NFKBIA/CXCL6	179
KEGG	hsa05222	Small cell lung cancer	89/6848	92/8135	0.0001235	0.0006159	0.000264	COL4A6/LAMB4/PTK2/POLK/LAMA3/ZBTB17/NOS2/ITGA2B/TP53/BCL2/E2F2/ITGB1/AKT2/LAMC3/BCL2L1/RXRB/COL4A5/RB1/TRAF6/MAX/RXRG/RARB/AKT1/IKBKG/IKBKB/E2F1/PIK3R2/RXRA/FN1/CDK2/COL4A3/AKT3/PTEN/LAMA4/BIRC7/CDK4/CHUK/CASP9/XIAP/LAMC1/RELA/PIK3CB/CASP3/APAF1/CKS1B/LAMB2/E2F3/TRAF2/LAMA5/FHIT/ITGAV/PIK3R3/CDKN1A/PIK3R1/SKP2/ITGA3/TRAF5/BIRC2/BAX/TRAF4/MYC/BAK1/PIK3CA/COL4A2/CCNE1/PIK3CD/CYCS/TRAF3/LAMB1/LAMA1/LAMC2/GADD45G/COL4A1/CDK6/CDKN2B/ITGA6/CCNE2/CCND1/DDB2/CDKN1B/LAMA2/GADD45A/ITGA2/NFKB1/TRAF1/COL4A4/GADD45B/LAMB3/NFKBIA	89
KEGG	hsa04720	Long-term potentiation	66/6848	67/8135	0.000127	0.0006236	0.0002673	GRIN1/PLCB2/GRM5/GRIA2/GRM1/PPP3CB/PRKCG/PRKCB/CAMK2B/PRKACB/GRIN2C/PPP3R2/RAP1A/CAMK4/PRKACA/ARAF/MAPK1/CALML4/GRIN2B/RAPGEF3/KRAS/MAPK3/PPP1CC/RAF1/CALM2/PPP1R1A/ADCY1/PPP1CB/CALML6/PLCB3/CALM3/PPP1CA/GRIN2D/BRAF/MAP2K2/PRKCA/CALML3/PRKACG/ITPR2/CALML5/RPS6KA6/GNAQ/CREBBP/RPS6KA1/CAMK2A/RAP1B/ITPR3/PPP3CA/HRAS/CAMK2G/RPS6KA2/CACNA1C/GRIN2A/NRAS/EP300/CALM1/ATF4/MAP2K1/PLCB1/GRIA1/CAMK2D/ADCY8/ITPR1/RPS6KA3/PLCB4/PPP3R1	66
KEGG	hsa05146	Amoebiasis	98/6848	102/8135	0.0001457	0.0006974	0.0002989	SERPINB13/COL4A6/PLCB2/LAMB4/CD1E/C8A/PTK2/LAMA3/PRKCG/PRKCB/PRKACB/NOS2/GNAS/RAB5C/PRKACA/CD1C/LAMC3/COL4A5/MUC2/RAB5A/IL1R2/IFNG/SERPINB3/ARG1/IL12B/CD1A/C8B/SERPINB6/RAB7A/RAB5B/ADCY1/PIK3R2/IL1R1/PLCB3/FN1/TGFB1/SERPINB10/CD1B/COL4A3/ITGAM/CTSG/ACTN4/LAMA4/PRKCA/GNAL/PRKACG/PRDX1/TGFB3/HSPB1/GNAQ/C8G/C9/LAMC1/RELA/VCL/IL10/PIK3CB/CASP3/LAMB2/LAMA5/COL1A1/COL1A2/PIK3R3/CD1D/PIK3R1/RAB7B/GNA15/PLCB1/TNF/PIK3CA/ARG2/COL4A2/SERPINB4/PIK3CD/GNA11/SERPINB9/TLR2/LAMB1/ACTN1/LAMA1/LAMC2/COL3A1/IL12A/COL4A1/TLR4/PLCB4/ITGB2/TGFB2/LAMA2/CD14/GNA14/NFKB1/COL4A4/CXCL1/CXCL3/CXCL8/CXCL2/LAMB3	98
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	77/6848	79/8135	0.0001462	0.0006974	0.0002989	ERBB3/PDGFB/TGFA/PRKCG/PRKCB/RPS6/NRG2/ERBB2/RPS6KB1/BCL2/PDGFRA/ARAF/MAPK1/NF1/AKT2/BCL2L1/EIF4E2/KRAS/BAD/EGFR/EGF/PLCG2/MAPK3/SRC/RAF1/FGFR3/AKT1/PLCG1/SHC1/RPS6KB2/PIK3R2/BCL2L11/GRB2/AKT3/BRAF/SHC4/MAP2K2/PTEN/PRKCA/SHC3/AXL/STAT3/PIK3CB/SOS2/JAK1/FGFR2/GSK3B/HRAS/PIK3R3/SOS1/NRAS/PDGFRB/PIK3R1/FOXO3/MAP2K1/KDR/BAX/PDGFC/MTOR/MET/SHC2/NRG1/EIF4E/PIK3CA/IGF1R/PIK3CD/PDGFD/VEGFA/HGF/IL6R/GAS6/EIF4EBP1/GAB1/JAK2/PDGFA/FGF2/IGF1	77
KEGG	hsa05012	Parkinson disease	244/6848	266/8135	0.0001672	0.0007866	0.0003371	PRKN/RPS27A/TUBB1/RYR3/ATF6/NDUFA11/SLC39A3/DRD2/KLC4/SLC39A1/COX8C/UBB/CAMK2B/UBA52/KLC3/SLC25A31/SLC18A2/UBA1/ATP5F1C/PRKACB/KIF5A/GNAS/PSMA8/UBC/SLC39A12/NDUFS3/TP53/PSMB4/MAPT/PSMD4/PRKACA/NDUFA10/ATP5PB/UQCRFS1/NDUFC2/COX4I1/SLC18A1/CALML4/NDUFV1/SLC39A9/BCL2L1/SDHC/SLC39A2/SLC39A6/ATP5PF/COX6A1/UQCRC1/ATP5F1A/SLC39A5/UQCR10/PSMD6/VDAC3/SLC39A13/UBE2G1/GNAI3/NDUFB4/SNCA/PARK7/MAPK9/UQCRH/COX6B1/NDUFS4/TUBAL3/NDUFB8/CALM2/KIF5B/PSMC2/NDUFB9/PSMB1/COX7B2/UBE2J2/NDUFB10/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/PLCG1/COX8A/MFN2/NDUFA9/PSMA1/NDUFB5/PSMC1/COX5A/UBE2L3/TH/SEM1/SEPTIN5/SDHD/KLC1/ATP5F1D/CALML6/ATP5PD/UQCR11/PSMB5/COX2/PSMD9/SDHB/NDUFS7/TUBA8/MFN1/NDUFB2/ND4/CALM3/ERN1/NDUFA2/ATP5F1B/TXN2/NDUFA6/COX6B2/NDUFB6/COX4I2/SLC6A3/NDUFB3/HTRA2/SOD1/COX7A2L/PSMD1/TUBA3C/ADCY5/PSMD2/UQCRQ/NDUFA1/NDUFA5/PSMD7/GNAI2/COX7C/TUBB4A/PSMB2/UQCRB/SDHA/PSMC6/TUBA1A/CALML3/GNAL/NDUFB7/PRKACG/COX6C/NDUFB11/UBE2G2/SLC25A5/NDUFA12/NDUFA3/UBA7/CASP9/ITPR2/KEAP1/NDUFC1/CALML5/PSMA2/MAPK8/ATP5F1E/PSMD13/NDUFS2/CAMK2A/SLC39A10/UBE2J1/NDUFB1/ATP5MC3/NDUFV2/KLC2/TUBB/PSMD8/ATP5MC2/NDUFS5/NDUFA7/SLC25A4/PSMB6/PSMB7/PSMD3/PSMB3/SLC39A4/TRAP1/CASP3/KIF5C/PSMC5/APAF1/XBP1/ADRM1/PSMA3/CYC1/PSMA5/COX7A2/ITPR3/PSMC3/NDUFS1/GPR37/PINK1/SLC39A11/PSMC4/CAMK2G/EIF2S1/SLC39A14/TXN/PSMD11/NDUFS8/PSMD12/ATP5MC1/SNCAIP/CALM1/ATF4/UCHL1/TUBA1C/MCU/ND5/PSMA4/COX7B/BAX/DAXX/VDAC1/PPIF/PSMD14/PSMA7/UBE2L6/NDUFV3/TUBA1B/DRD1/TUBB4B/MAOA/CAMK2D/HSPA5/EIF2AK3/TUBB3/CYCS/ITPR1/TUBB6/DDIT3/TUBA4A/MAPK10/PSMA6/NFE2L2/GNAI1/SLC39A8/COX7A1/NDUFA4/NDUFA4L2/DUSP1/MAOB/TUBB2A/LRRK2/SLC11A2/TUBB2B/MAP3K5	244
KEGG	hsa04721	Synaptic vesicle cycle	76/6848	78/8135	0.0001698	0.0007877	0.0003376	AP2A1/NAPA/UNC13C/SLC6A2/ATP6V1C2/CACNA1B/SLC6A4/ATP6V0C/CLTC/SNAP25/AP2M1/VAMP2/SLC1A6/CPLX1/ATP6V0A1/CPLX2/SLC18A2/ATP6V1F/DNM2/ATP6V0D2/AP2A2/SLC6A12/SLC6A7/ATP6V0E1/ATP6V1B1/UNC13A/ATP6V0D1/SLC6A5/SLC18A1/SLC6A11/SLC17A8/ATP6V0A4/SLC32A1/RAB3A/DNM3/STXBP1/ATP6V1G3/CLTA/SLC18A3/SLC17A7/SLC1A7/ATP6V1D/AP2S1/ATP6V1E1/AP2B1/SLC6A13/SLC6A1/SLC6A3/SLC1A2/STX1B/CLTCL1/TCIRG1/SLC17A6/NSF/SLC6A9/ATP6V1G2/ATP6V1E2/CPLX3/SYT1/UNC13B/ATP6V1C1/RIMS1/CACNA1A/ATP6V1A/STX2/ATP6V1G1/ATP6V1H/ATP6V1B2/STX3/ATP6V0B/ATP6V0A2/SLC1A3/STX1A/DNM1/SLC1A1/ATP6V0E2	76
KEGG	hsa04927	Cortisol synthesis and secretion	64/6848	65/8135	0.0001747	0.0007989	0.0003424	PLCB2/KCNK3/CACNA1I/ATF2/CACNA1D/MRAP/PRKACB/KCNA4/GNAS/MC2R/PRKACA/CREB3L3/POMC/NR5A1/HSD3B2/CREB1/HSD3B1/CYP17A1/CYP11B1/CACNA1S/SP1/CACNA1G/ADCY2/ADCY1/CACNA1H/SCARB1/PLCB3/ATF6B/ADCY9/ADCY5/CACNA1F/STAR/PRKACG/ADCY3/CREB3L1/ITPR2/GNAQ/CREB3/ADCY6/PDE8A/ADCY7/ITPR3/CACNA1C/ORAI1/CYP11A1/ATF4/CREB3L4/CREB3L2/PLCB1/PBX1/ADCY8/PDE8B/GNA11/ITPR1/KCNK2/NR0B1/LDLR/NR4A1/CREB5/ADCY4/PLCB4/NCEH1/AGT/AGTR1	64
KEGG	hsa05110	Vibrio cholerae infection	50/6848	50/8135	0.000177	0.0007989	0.0003424	KDELR1/CFTR/ATP6V1C2/ATP6V0C/ATP6V0A1/ATP6V1F/ATP6V0D2/PRKACB/SEC61A2/GNAS/ATP6V0E1/PRKACA/ATP6V1B1/ATP6V0D1/KCNQ1/ATP6V0A4/PLCG2/ATP6V1G3/ATP6V1D/PLCG1/ATP6V1E1/ATP6AP1/TJP1/ARF1/ADCY9/ACTB/SLC12A2/TCIRG1/PRKCA/PRKACG/ADCY3/ATP6V1G2/ATP6V1E2/SEC61A1/ATP6V1C1/SEC61B/ACTG1/ATP6V1A/KDELR3/ATP6V1G1/ATP6V1H/ATP6V1B2/ATP6V0B/ATP6V0A2/ERO1A/KDELR2/ATP6V0E2/SEC61G/PDIA4/TJP2	50
KEGG	hsa04211	Longevity regulating pathway	86/6848	89/8135	0.0001894	0.0008325	0.0003568	ATF2/STK11/AKT1S1/PRKACB/ATG5/CAMK4/TP53/TSC2/INS/EHMT1/RPS6KB1/PRKACA/CREB3L3/AKT2/IRS4/EIF4E2/PRKAA1/KRAS/CREB1/RHEB/ADIPOQ/PRKAG1/AKT1/CAMKK2/ADCY2/ADCY1/RPS6KB2/PIK3R2/ATF6B/ADCY9/ADIPOR1/PRKAB1/ADCY5/PRKAA2/AKT3/PRKACG/RPTOR/ADCY3/CREB3L1/CREB3/ADIPOR2/ADCY6/KL/ATG101/RELA/PRKAG3/TSC1/PIK3CB/ADCY7/APPL1/HRAS/PRKAG2/PRKAB2/PIK3R3/NRAS/PIK3R1/ATF4/FOXO3/CREB3L4/BAX/MTOR/CREB3L2/EIF4E/PIK3CA/IGF1R/ADCY8/SIRT1/PIK3CD/SESN2/SESN3/SESN1/INSR/EIF4EBP1/FOXO1/CAT/CREB5/PPARG/ADCY4/RB1CC1/ULK1/IRS1/PPARGC1A/NFKB1/IGF1/IRS2/SOD2	86
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	86/6848	89/8135	0.0001894	0.0008325	0.0003568	PTPN11/MAPK11/PPP3CB/BATF/CD28/PPP3R2/CD3E/ALK/ZAP70/RPS6KB1/MAPK12/MAPK1/TIRAP/AKT2/KRAS/MAPK14/CSNK2B/CD3G/EGFR/EGF/CSNK2A1/MAPK3/TRAF6/IFNG/RAF1/AKT1/IKBKG/IKBKB/CD4/PLCG1/LCK/CD3D/PRKCQ/RPS6KB2/PIK3R2/NFATC2/PDCD1/PTPN6/CSNK2A2/AKT3/MAP2K2/PTEN/HIF1A/CHUK/MAP3K3/RELA/LAT/MYD88/STAT3/PIK3CB/NFKBIB/JAK1/PPP3CA/NFATC3/HRAS/PIK3R3/BATF2/NRAS/PIK3R1/MAP2K1/TICAM2/MTOR/EML4/IFNGR1/MAP2K6/PIK3CA/PIK3CD/TICAM1/TLR2/STAT1/CD247/BATF3/MAPK13/JAK2/MAP2K3/TLR4/IFNGR2/NFATC1/NFKB1/CD274/PPP3R1/JUN/RASGRP1/NFKBIE/FOS/NFKBIA	86
KEGG	hsa05225	Hepatocellular carcinoma	157/6848	168/8135	0.0002084	0.000904	0.0003875	DPF1/ACTL6B/SMARCB1/WNT10A/TERT/POLK/TGFA/PRKCG/ARID1A/PRKCB/SMAD4/SMAD2/WNT16/TP53/RPS6KB1/TXNRD2/WNT2B/ARAF/MAPK1/SMARCD1/E2F2/WNT3/AKT2/BCL2L1/WNT6/WNT10B/KRAS/APC2/BAD/WNT8B/CDKN2A/EGFR/PLCG2/MAPK3/RB1/WNT1/AXIN1/CSNK1A1/RAF1/AKT1/ELK1/FZD9/WNT7B/PLCG1/WNT7A/SHC1/E2F1/GSTA1/RPS6KB2/PIK3R2/TGFBR2/FZD3/GSTP1/AXIN2/PBRM1/TGFB1/DVL3/GRB2/ACTB/BRD7/DVL1/AKT3/WNT8A/FZD1/BRAF/SHC4/MAP2K2/PTEN/SMARCA4/PRKCA/APC/WNT9B/SMARCE1/CDK4/DVL2/GSTA3/TGFB3/SHC3/KEAP1/GSTM4/SMARCC1/LEF1/MGST3/TCF7/SMAD3/SMARCD3/WNT11/PIK3CB/SMARCC2/SOS2/ACTL6A/ACTG1/GSTO2/GSTM1/E2F3/TGFBR1/WNT9A/GSK3B/HRAS/ARID1B/SMARCD2/PIK3R3/WNT5B/SOS1/NRAS/CDKN1A/PIK3R1/GSTA4/MGST1/MAP2K1/LRP5/GSTO1/BAX/MTOR/ARID2/DPF3/NQO1/MET/MYC/PHF10/BAK1/SHC2/FZD8/TXNRD1/PIK3CA/IGF1R/FZD4/TCF7L1/PIK3CD/FZD5/IGF2/HGF/FZD6/SMARCA2/GADD45G/LRP6/GAB1/NFE2L2/CDK6/FZD2/TCF7L2/CCND1/MGST2/FRAT2/DDB2/WNT4/GSTM3/GSTM5/TGFB2/HMOX1/GADD45A/FRAT1/WNT5A/GADD45B/FZD7/WNT2/CTNNB1	157
KEGG	hsa04540	Gap junction	85/6848	88/8135	0.0002183	0.0009347	0.0004006	PLCB2/GRM5/TUBB1/GRM1/PDGFB/PRKCG/DRD2/ADRB1/PRKCB/HTR2C/PRKACB/GNAS/PRKACA/PDGFRA/MAPK1/CSNK1D/KRAS/EGFR/EGF/GNAI3/MAPK3/GJD2/SRC/TUBAL3/RAF1/TJP1/ADCY2/ADCY1/PLCB3/TUBA8/ADCY9/GRB2/TUBA3C/ADCY5/GNAI2/TUBB4A/MAP2K2/PRKCA/TUBA1A/PRKACG/ADCY3/ITPR2/MAP3K2/GUCY1A1/GNAQ/ADCY6/TUBB/MAPK7/SOS2/ADCY7/ITPR3/HRAS/SOS1/GJA1/NRAS/PDGFRB/LPAR1/MAP2K1/TUBA1C/PRKG1/PDGFC/GUCY1B1/PLCB1/TUBA1B/DRD1/TUBB4B/ADCY8/TUBB3/GNA11/ITPR1/TUBB6/PDGFD/TUBA4A/CDK1/GUCY1A2/MAP2K5/GNAI1/PRKG2/ADCY4/PLCB4/TUBB2A/HTR2A/PDGFA/HTR2B/TUBB2B	85
KEGG	hsa04066	HIF-1 signaling pathway	104/6848	109/8135	0.0002358	0.0009969	0.0004273	HKDC1/ALDOB/CYBB/EPO/PRKCG/PRKCB/CAMK2B/TF/RPS6/MKNK1/NOS2/NPPA/ERBB2/LDHAL6B/INS/RPS6KB1/BCL2/MAPK1/AKT2/ANGPT4/NOS3/EIF4E2/ELOB/EGLN2/ANGPT2/LTBR/EGFR/ARNT/EGF/PLCG2/HK3/MAPK3/GAPDH/IFNG/AKT1/PLCG1/PDHA1/TFRC/RPS6KB2/PIK3R2/PGK2/LDHB/PFKL/AKT3/ENO3/PDHA2/MAP2K2/LDHA/PRKCA/HIF1A/ELOC/ALDOA/CREBBP/CAMK2A/TIMP1/HK1/RELA/PDHB/STAT3/PIK3CB/CUL2/EGLN3/LDHC/PGK1/VHL/CAMK2G/PIK3R3/EGLN1/PFKM/CDKN1A/PIK3R1/EP300/PDK1/ENO1/MAP2K1/TEK/MTOR/ALDOC/IFNGR1/EIF4E/PIK3CA/IGF1R/CAMK2D/ANGPT1/ENO2/PIK3CD/VEGFA/FLT1/IL6R/HK2/INSR/EIF4EBP1/SERPINE1/PFKP/TLR4/MKNK2/IFNGR2/HMOX1/CDKN1B/NFKB1/IGF1/PFKFB3/SLC2A1/EDN1	104
KEGG	hsa00280	Valine, leucine and isoleucine degradation	48/6848	48/8135	0.0002503	0.001034	0.0004433	HMGCLL1/ACSF3/HMGCS2/OXCT2/MCCC2/ECHS1/DLD/ACAA1/ACAT1/ACADS/BCKDHA/HADHA/AGXT2/AACS/ACAA2/PCCB/HADHB/HMGCL/ACADM/IVD/BCAT2/DBT/EHHADH/HSD17B10/HIBCH/ACAD8/MMUT/BCKDHB/HADH/ALDH6A1/ACADSB/ALDH9A1/MCCC1/PCCA/HIBADH/ACAT2/OXCT1/AOX1/BCAT1/MCEE/ALDH2/HMGCS1/ALDH7A1/ALDH3A2/ALDH1B1/ABAT/AUH/IL4I1	48
KEGG	hsa01522	Endocrine resistance	94/6848	98/8135	0.0002508	0.001034	0.0004433	ESR1/NOTCH3/MAPK11/PTK2/ABCB11/ESR2/DLL1/PRKACB/GNAS/ERBB2/TP53/RPS6KB1/BCL2/PRKACA/MAPK12/ARAF/MAPK1/E2F2/AKT2/KRAS/MAPK14/BAD/CDKN2A/EGFR/MAPK3/DLL3/SRC/RB1/MAPK9/RAF1/BIK/SP1/AKT1/MMP2/NCOR1/ADCY2/SHC1/E2F1/ADCY1/RPS6KB2/PIK3R2/ADCY9/CARM1/GRB2/ADCY5/AKT3/BRAF/SHC4/MAP2K2/PRKACG/ADCY3/JAG2/CDK4/SHC3/MED1/MAPK8/ADCY6/NOTCH2/NOTCH4/MDM2/PIK3CB/NOTCH1/SOS2/ADCY7/E2F3/HRAS/PIK3R3/CYP2D6/GPER1/SOS1/NRAS/CDKN1A/PIK3R1/MAP2K1/BAX/MMP9/MTOR/SHC2/NCOA3/PIK3CA/IGF1R/ADCY8/PIK3CD/MAPK10/CDKN2C/MAPK13/JAG1/ADCY4/CCND1/CDKN1B/HBEGF/JUN/IGF1/FOS	94
KEGG	hsa04918	Thyroid hormone synthesis	73/6848	75/8135	0.0002657	0.001082	0.0004638	ALB/IYD/PLCB2/ATF2/ASGR1/ATP1A4/ASGR2/PRKCG/PRKCB/TG/GPX5/GPX2/PRKACB/TSHB/FXYD2/GNAS/ATP1A2/ATP1B4/PRKACA/CREB3L3/ATP1B2/LRP2/SLC5A5/TSHR/CREB1/ATP1A1/DUOXA2/DUOX1/DUOX2/SERPINA7/ADCY2/ADCY1/ATP1B3/PLCB3/ATF6B/ADCY9/ATP1A3/TTR/ADCY5/TTF1/TPO/PAX8/PRKCA/PRKACG/ADCY3/CREB3L1/ITPR2/TTF2/CGA/GNAQ/CREB3/ADCY6/ADCY7/ITPR3/GSR/GPX1/ATF4/CREB3L4/GPX8/GPX3/CREB3L2/PLCB1/ADCY8/HSPA5/GPX7/ITPR1/HSP90B1/CREB5/PDIA4/ADCY4/PLCB4/SLC26A4/ATP1B1	73
KEGG	hsa04911	Insulin secretion	83/6848	86/8135	0.0002895	0.001165	0.0004994	GLP1R/PLCB2/ATF2/ATP1A4/RYR2/SNAP25/CACNA1D/PRKCG/PDX1/PRKCB/VAMP2/CAMK2B/KCNN2/PRKACB/CCK/KCNN3/RIMS2/FXYD2/GNAS/KCNJ11/INS/ATP1A2/ADCYAP1/ATP1B4/PRKACA/CREB3L3/ATP1B2/KCNU1/PCLO/CREB1/FFAR1/RAB3A/ATP1A1/CACNA1S/CHRM3/ADCYAP1R1/TRPM4/CCKAR/SLC2A2/GCG/ADCY2/ADCY1/ATP1B3/PLCB3/ATF6B/ADCY9/ATP1A3/KCNN1/GIP/KCNMB3/ADCY5/CACNA1F/PRKCA/PRKACG/ADCY3/CREB3L1/ABCC8/GNAQ/CREB3/CAMK2A/ADCY6/ADCY7/ITPR3/CAMK2G/CACNA1C/ATF4/CREB3L4/STX1A/CREB3L2/PLCB1/KCNMB1/CAMK2D/ADCY8/KCNMB2/RAPGEF4/GNA11/KCNN4/CREB5/ADCY4/PLCB4/KCNMB4/ATP1B1/SLC2A1	83
KEGG	hsa00561	Glycerolipid metabolism	60/6848	61/8135	0.0003298	0.00131	0.0005613	TKFC/DGKB/PNPLA2/DGKZ/DGKE/MOGAT2/PNLIP/PNLIPRP1/AGPAT1/LIPF/DGKA/LPIN3/CEL/GLYCTK/DGAT1/GK2/MOGAT1/DGKG/PNLIPRP3/GPAT4/LPIN2/DGKQ/MOGAT3/PNLIPRP2/AGK/AGPAT2/LCLAT1/DGKH/AKR1A1/AGPAT3/PLPP2/DGKD/LPL/AKR1B10/GLA/LPIN1/MBOAT2/DGAT2/PLPP3/ALDH9A1/PLPP5/LIPC/GK/GPAM/PLPP1/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/AGPAT5/AGPAT4/GPAT2/MBOAT1/MGLL/GPAT3/AKR1B1/PNPLA3/PLPP4/LIPG/DGKI	60
KEGG	hsa04012	ErbB signaling pathway	82/6848	85/8135	0.0003333	0.00131	0.0005613	ERBB3/PAK5/PAK4/PTK2/TGFA/PRKCG/PRKCB/CAMK2B/NRG3/NRG2/ERBB2/PAK6/RPS6KB1/MAP2K7/ARAF/MAPK1/AKT2/ERBB4/KRAS/BAD/EGFR/EGF/PLCG2/MAPK3/SRC/MAPK9/CBL/RAF1/PAK2/NRG4/AKT1/ELK1/PLCG1/MAP2K4/SHC1/RPS6KB2/PIK3R2/GRB2/BTC/AKT3/BRAF/SHC4/MAP2K2/PRKCA/STAT5B/CRKL/SHC3/MAPK8/CAMK2A/CRK/PIK3CB/SOS2/GSK3B/HRAS/CAMK2G/PAK1/PIK3R3/SOS1/NRAS/CDKN1A/PIK3R1/AREG/MAP2K1/NCK1/MTOR/PAK3/MYC/NCK2/SHC2/NRG1/ABL1/PIK3CA/CAMK2D/PIK3CD/EIF4EBP1/GAB1/MAPK10/ABL2/CBLB/CDKN1B/HBEGF/JUN	82
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	101/6848	106/8135	0.0003477	0.00135	0.0005788	CASR/PLCB2/GNA13/PDE4C/ATF2/PDE4A/TNFSF11/MMP24/PRKCG/ARRB2/PRKCB/SLC34A1/PRKACB/MMP16/GNAS/ARHGEF1/BCL2/PRKACA/FGF23/CREB3L3/ARAF/MAPK1/SOST/RXRB/GCM2/MMP17/CREB1/NACA/EGFR/MMP15/PTH/GNAI3/MAPK3/SLC34A2/RAF1/GCM1/ARHGEF11/SP1/RXRG/TRPV5/GATA3/SLC34A3/PLD2/ADCY2/RHOA/ADCY1/GNA12/PLCB3/RXRA/ATF6B/ADCY9/PDE4D/ADCY5/MEF2D/PTH1R/GNAI2/BRAF/PRKCA/PRKACG/ADCY3/CREB3L1/ITPR2/CYP27B1/GNAQ/CREB3/ADCY6/KL/ADCY7/ITPR3/MEF2C/JUND/ARRB1/CDKN1A/ATF4/MMP14/CREB3L4/MAP2K1/LRP5/SLC9A3R1/CREB3L2/PLCB1/ADCY8/GNA11/ITPR1/AKAP13/LRP6/VDR/GNAI1/PLD1/CREB5/PTHLH/ADCY4/PLCB4/HBEGF/MEF2A/CYP24A1/PDE4B/MAFB/FOS/EGR1/NR4A2	101
KEGG	hsa00562	Inositol phosphate metabolism	71/6848	73/8135	0.0003575	0.001372	0.0005882	PLCH1/OCRL/PLCB2/MTMR8/INPP5D/MTMR7/PIK3CG/INPP5J/PIKFYVE/PIK3C2A/INPP5B/MIOX/PIP4K2B/PLCG2/PLCZ1/INPP4A/ITPK1/PLCH2/PI4KB/PLCD1/PIP5K1C/PLCG1/PIK3C2G/ISYNA1/INPP5K/MTMR2/PI4K2A/PIP5KL1/PIK3C3/PLCB3/MTMR14/PIP5K1B/MTMR1/MTMR6/INPP5E/MTMR3/CDIPT/PTEN/INPP5A/PIP4K2A/INPP5F/INPP1/PLCD3/SACM1L/IPMK/ITPKA/INPPL1/MTM1/IMPA1/PIK3CB/FIG4/MINPP1/PIP5K1A/IPPK/PIP4K2C/ALDH6A1/PLCD4/PI4K2B/ITPKB/PLCB1/PIK3CA/SYNJ1/ITPKC/PIK3CD/PIK3C2B/MTMR4/SYNJ2/IMPA2/PLCE1/INPP4B/PLCB4	71
KEGG	hsa05016	Huntington disease	278/6848	306/8135	0.0003728	0.001415	0.0006065	DNAH6/GRIN1/AP2A1/HAP1/PLCB2/DNAH3/GRM5/TUBB1/GRIA2/DCTN4/NDUFA11/CACNA1B/DNAH11/POLR2A/CLTC/GRIA4/AP2M1/KLC4/GPX5/COX8C/DCTN6/KLC3/SLC25A31/POLR2B/GPX2/DNAH1/DNAH12/ATP5F1C/AP2A2/DNAH9/KIF5A/KCNJ10/PSMA8/NDUFS3/DNAH17/TP53/PSMB4/ACTR1A/UCP1/PSMD4/MAP2K7/CREB3L3/DNAI2/NDUFA10/ATP5PB/UQCRFS1/NDUFC2/DLG4/COX4I1/DCTN3/DNAH2/NDUFV1/GRIN2B/SDHC/NRF1/ATP5PF/DNAH8/DCTN1/BECN1/CREB1/COX6A1/UQCRC1/ATP5F1A/UQCR10/PSMD6/VDAC3/MAP3K10/POLR2C/NDUFB4/DNAH14/DNAH10/MAPK9/UQCRH/COX6B1/NDUFS4/TUBAL3/DCTN2/NDUFB8/KIF5B/CLTA/PSMC2/NDUFB9/PSMB1/SP1/COX7B2/NDUFB10/HTT/DNAI1/AMBRA1/NDUFA13/AP2S1/TBP/VDAC2/POLR2E/NDUFA8/COX5B/SLC25A6/ACTR10/COX8A/NDUFA9/AP2B1/PSMA1/NDUFB5/PSMC1/COX5A/SEM1/SDHD/KLC1/ATP5F1D/ACTR1B/ATP5PD/UQCR11/PSMB5/COX2/PIK3C3/PLCB3/PSMD9/SDHB/NDUFS7/TUBA8/WIPI2/NDUFB2/ND4/ERN1/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/CASP8/COX4I2/POLR2F/SLC1A2/ATG2B/NDUFB3/SOD1/COX7A2L/PSMD1/TUBA3C/PSMD2/CLTCL1/UQCRQ/NDUFA1/POLR2L/NDUFA5/PSMD7/COX7C/TUBB4A/PSMB2/UQCRB/DNAH5/SDHA/PSMC6/TUBA1A/TAF4/DCTN5/NDUFB7/CREB3L1/COX6C/NDUFB11/IFT57/SLC25A5/NDUFA12/NDUFA3/CASP9/NDUFC1/POLR2H/PSMA2/GNAQ/CREB3/MAPK8/ATP5F1E/PSMD13/POLR2G/CREBBP/NDUFS2/DNAL1/NDUFB1/ATG101/ATP5MC3/NDUFV2/KLC2/TUBB/HDAC1/PSMD8/ATP5MC2/NDUFS5/NDUFA7/TBPL1/PIK3R4/SLC25A4/REST/PSMB6/PSMB7/PSMD3/POLR2D/PSMB3/CASP3/KIF5C/PSMC5/RCOR1/APAF1/ADRM1/PSMA3/CYC1/DNAL4/PSMA5/NRBF2/COX7A2/PSMC3/NDUFS1/TRAF2/PSMC4/DNAH7/POLR2K/PSMD11/NDUFS8/PSMD12/ATG2A/GPX1/EP300/ATP5MC1/HDAC2/CREB3L4/TUBA1C/BBC3/ND5/PSMA4/SLC1A3/COX7B/DNALI1/BAX/STX1A/GPX8/VDAC1/POLR2I/PPIF/PSMD14/PSMA7/MTOR/TFAM/GPX3/CREB3L2/PLCB1/NDUFV3/TUBA1B/GRIA1/TUBB4B/TGM2/GPX7/TUBB3/CYCS/ITPR1/ULK2/TAF4B/TUBB6/GRIA3/TUBA4A/HIP1/SIN3A/MAPK10/PSMA6/COX7A1/NDUFA4/CREB5/PPARG/NDUFA4L2/PLCB4/RB1CC1/ULK1/BDNF/POLR2J3/TUBB2A/WIPI1/PPARGC1A/TUBB2B/MAP3K5/SOD2	278
KEGG	hsa05010	Alzheimer disease	346/6848	384/8135	0.0003994	0.001499	0.0006425	NCSTN/NOX1/GRIN1/NOS1/PLCB2/GRM5/CYBB/TUBB1/RYR3/ATF6/NDUFA11/WNT10A/CACNA1D/SLC39A3/PPP3CB/KLC4/SLC39A1/COX8C/KLC3/SLC25A31/ATP5F1C/NOS2/KIF5A/GRIN2C/PPP3R2/WNT16/ATP2A1/PSMA8/SLC39A12/NDUFS3/PSMB4/INS/MAPT/PSMD4/WNT2B/MAP2K7/ARAF/NDUFA10/ATP5PB/UQCRFS1/MAPK1/NDUFC2/COX4I1/WNT3/CALML4/AKT2/IRS4/NDUFV1/SLC39A9/GRIN2B/SDHC/WNT6/WNT10B/SLC39A2/SLC39A6/ATP5PF/ATP2A3/BECN1/KRAS/APC2/CSNK2B/BAD/COX6A1/UQCRC1/ATP5F1A/WNT8B/SLC39A5/UQCR10/TNFRSF1A/IDE/PSMD6/VDAC3/SLC39A13/CSNK2A1/MAPK3/NDUFB4/GAPDH/WNT1/SNCA/MAPK9/UQCRH/COX6B1/NDUFS4/DKK4/AXIN1/CSNK1A1/DKK2/TUBAL3/NDUFB8/RAF1/CACNA1S/CALM2/CHRM3/KIF5B/PSMC2/NDUFB9/PSMB1/COX7B2/NDUFB10/AKT1/IKBKG/FZD9/IKBKB/AMBRA1/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/WNT7B/COX8A/WNT7A/NDUFA9/CDK5R1/PSMA1/NDUFB5/PSMC1/COX5A/ATP2A2/SEM1/SDHD/CAPN1/PIK3R2/KLC1/ATP5F1D/CALML6/ATP5PD/CSNK1E/UQCR11/FZD3/PSMB5/COX2/PIK3C3/PLCB3/PSMD9/SDHB/NDUFS7/AXIN2/TUBA8/WIPI2/ADAM10/NDUFB2/ND4/CSNK2A2/CHRM1/BACE1/CALM3/ERN1/PSEN1/NDUFA2/ATP5F1B/NDUFA6/DVL3/COX6B2/NDUFB6/CASP8/COX4I2/LRP1/NAE1/ATG2B/NDUFB3/CHRM5/COX7A2L/APBB1/PSMD1/TUBA3C/DVL1/PSMD2/AKT3/UQCRQ/NDUFA1/WNT8A/NDUFA5/PSMD7/GRIN2D/CACNA1F/COX7C/FZD1/TUBB4A/PSMB2/BRAF/UQCRB/MAP2K2/SDHA/CAPN2/PSMC6/TUBA1A/CALML3/APC/NDUFB7/WNT9B/COX6C/NDUFB11/APH1A/SLC25A5/DVL2/NDUFA12/CHUK/NDUFA3/CASP9/ITPR2/NDUFC1/CALML5/PSMA2/GNAQ/MAPK8/ATP5F1E/PSMD13/NDUFS2/CSF1/APH1B/SLC39A10/NDUFB1/ATG101/RELA/PSEN2/ATP5MC3/CDK5/NDUFV2/KLC2/TUBB/PSMD8/ATP5MC2/NDUFS5/NDUFA7/WNT11/PIK3R4/LPL/SLC25A4/PSMB6/PSMB7/PIK3CB/PSMD3/PSMB3/SLC39A4/CASP3/KIF5C/PSMC5/APAF1/XBP1/ADRM1/PSMA3/CYC1/PSMA5/NRBF2/COX7A2/PPID/ITPR3/WNT9A/PSMC3/NDUFS1/PPP3CA/TRAF2/GSK3B/SLC39A11/PSMC4/HRAS/PIK3R3/HSD17B10/EIF2S1/SLC39A14/CACNA1C/WNT5B/RTN3/GRIN2A/PSMD11/NDUFS8/PSMD12/NRAS/EIF2AK2/ATG2A/PIK3R1/ATP5MC1/CALM1/ATF4/MAP2K1/TUBA1C/MCU/ND5/LRP5/PSMA4/COX7B/FADD/VDAC1/PPIF/PSMD14/PSMA7/MTOR/ADAM17/PLCB1/NDUFV3/TUBA1B/TNF/TUBB4B/PSENEN/FZD8/PIK3CA/FZD4/EIF2AK3/TUBB3/PIK3CD/CYCS/ITPR1/FAS/ULK2/TUBB6/FZD5/BACE2/APP/FZD6/DDIT3/LRP6/TUBA4A/INSR/MAPK10/PSMA6/SLC39A8/CASP7/COX7A1/NDUFA4/FZD2/NDUFA4L2/APOE/PLCB4/RB1CC1/ULK1/FRAT2/TUBB2A/WIPI1/WNT4/DKK1/SLC11A2/FRAT1/IRS1/WNT5A/NOX4/MME/NFKB1/PPP3R1/TUBB2B/MAP3K5/BID/IRS2/FZD7/WNT2/CTNNB1	346
KEGG	hsa05130	Pathogenic Escherichia coli infection	182/6848	197/8135	0.0004141	0.001505	0.0006451	MYH14/NLRP3/PTPN11/GNA13/TUBB1/CLDN18/FASLG/MAPK11/F2/LPAR5/CLDN19/CYTH4/TAB3/NLRP4/ROCK1/MYO1G/LPAR2/ARHGEF1/BRK1/CLDN3/MAPK12/MAPK1/MYH11/RPS3/TIRAP/SEC24B/ITGB1/CLDN8/MAPK14/TMED10/CLDN6/TNFRSF1A/MAPK3/CTTN/CLDN7/GAPDH/SRC/ROCK2/TRAF6/MAPK9/TUBAL3/PAK2/CLDN10/TAB1/ARHGEF11/RAB1A/IKBKG/WASF3/IKBKB/CLDN5/TMBIM6/TRADD/TJP1/RAC1/WIPF2/RHOA/CLDN17/GNA12/FCGR2A/CLDN15/IL1R1/MYO1A/MYO1F/TUBA8/ARF1/PTPN6/ABCF2/IRAK1/CLDN4/IRAK4/CASP8/CLDN2/ACTB/MYO1H/MYO5C/MAP3K7/TUBA3C/ARHGEF12/CLDN9/CYTH1/TUBB4A/CYTH3/MYO1C/SEC24C/ACTR3/TUBA1A/CLDN16/ACTR3B/NCKAP1L/CHUK/ARPC5/CASP9/SEC24A/MYH9/ARPC2/MAPK8/WIPF3/WASF2/CYTH2/NCKAP1/RELA/TUBB/MYD88/RIPK1/NCL/NFKBIB/TNFRSF10B/CASP3/CLDN11/ACTG1/CLDN20/ABI1/TLR5/TRAF2/ACTR2/ARPC1A/PAK1/MYO5A/ACTR3C/IL18/ARPC1B/LPAR1/ARHGEF2/TUBA1C/MYO1B/ARPC3/BAIAP2/SEC24D/SLC9A3R1/ARPC4/BAX/ARPC5L/FADD/NCK1/CYFIP2/LPAR4/TAB2/CDC42/PAK3/BAK1/NCK2/TUBA1B/MYO5B/TNF/TUBB4B/MYO6/CASP4/ABL1/ARF6/TUBB3/PYCARD/CYCS/WASF1/WIPF1/EZR/FAS/FYN/TUBB6/CASP1/MYO1E/BAIAP2L1/TUBA4A/MAPK10/WASL/MYH10/MAPK13/CASP7/TLR4/MYO1D/TUBB2A/HCLS1/CLDN14/NFKB1/JUN/CLDN23/TUBB2B/TNFSF10/FOS/MYO10/CXCL8/CLDN1/NFKBIA	182
KEGG	hsa05218	Melanoma	70/6848	72/8135	0.0004145	0.001505	0.0006451	PDGFB/POLK/FGF17/TP53/FGF21/FGF23/PDGFRA/ARAF/MAPK1/E2F2/AKT2/CDH1/KRAS/BAD/CDKN2A/EGFR/EGF/MAPK3/RB1/FGF3/RAF1/FGF6/FGF20/AKT1/FGF16/E2F1/PIK3R2/FGF4/FGF8/AKT3/BRAF/MAP2K2/PTEN/CDK4/FGF22/MDM2/PIK3CB/E2F3/HRAS/PIK3R3/NRAS/CDKN1A/PDGFRB/PIK3R1/MAP2K1/BAX/PDGFC/MET/BAK1/PIK3CA/IGF1R/FGF1/PIK3CD/PDGFD/FGF7/HGF/GADD45G/CDK6/CCND1/DDB2/FGF5/GADD45A/MITF/PDGFA/FGF2/FGF18/FGF9/IGF1/GADD45B/FGF10	70
KEGG	hsa04270	Vascular smooth muscle contraction	126/6848	134/8135	0.0004146	0.001505	0.0006451	MYH14/CALCA/ADRA1A/AVP/PLCB2/GNA13/CACNA1D/PRKCG/PRKCB/AVPR1A/PLA2G12B/PRKACB/ADRA1B/NPPA/ROCK1/GNAS/EDN3/ARHGEF1/PLA2G2D/PRKACA/ARAF/MAPK1/MYH11/PLA2G10/PLA2G4F/KCNU1/CALML4/PPP1R12B/ADRA1D/NPR1/MYLK4/MAPK3/PLA2G2F/ROCK2/PPP1CC/ADM2/RAF1/CACNA1S/CALM2/ARHGEF11/AVPR1B/MYLK2/PLA2G6/MYLK3/PLA2G3/MYL6/CALCB/ADCY2/RHOA/PRKCQ/ADCY1/GNA12/PPP1CB/NPPB/CALML6/EDN2/PLCB3/ADCY9/PRKCE/CALM3/PLA2G1B/RAMP3/KCNMB3/ADCY5/CALD1/ARHGEF12/PPP1CA/RAMP2/CACNA1F/PPP1R12C/BRAF/MAP2K2/PRKCA/CALML3/PRKACG/ADCY3/ACTG2/ITPR2/MYH9/GUCY1A1/CALML5/GNAQ/PPP1R14A/ADCY6/NPPC/PLA2G12A/ADCY7/ITPR3/PLA2G4C/MYL6B/PTGIR/MYL9/PPP1R12A/CACNA1C/CALCRL/CALM1/MAP2K1/PRKG1/GUCY1B1/PRKCH/ADM/NPR2/PLCB1/PLA2G5/KCNMB1/ADCY8/KCNMB2/ACTA2/PRKCD/GNA11/ITPR1/GUCY1A2/MRVI1/RAMP1/EDNRA/MYLK/MYH10/ADCY4/PLCB4/KCNMB4/PLA2G2A/ADORA2B/AGT/AGTR1/PLA2G4A/EDN1	126
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	134/6848	143/8135	0.0004326	0.001554	0.000666	PCGF1/JAK3/ACVR1B/WNT10A/MAPK11/SOX2/PAX6/SMAD4/SMAD2/WNT16/SETDB1/WNT2B/NANOG/MAPK12/MAPK1/WNT3/AKT2/WNT6/WNT10B/KRAS/APC2/MAPK14/WNT8B/ESRRB/DUSP9/LEFTY2/NODAL/MAPK3/WNT1/AXIN1/ESX1/NEUROG1/RAF1/FGFR3/AKT1/KAT6A/FZD9/TCF3/WNT7B/WNT7A/PIK3R2/LHX5/FZD3/PCGF3/AXIN2/ONECUT1/MYF5/DVL3/HESX1/GRB2/HOXB1/DVL1/AKT3/WNT8A/PCGF2/FZD1/RIF1/MAP2K2/APC/OTX1/WNT9B/DVL2/PCGF6/LEFTY1/ZFHX3/SMARCAD1/TCF7/SMAD3/HOXD1/ACVR2B/BMI1/POU5F1/ISL1/WNT11/STAT3/REST/PIK3CB/SMAD5/JAK1/ACVR1C/FGFR2/WNT9A/GSK3B/ZIC3/PCGF5/HRAS/PIK3R3/ACVR1/WNT5B/BMPR1A/NRAS/DLX5/PIK3R1/MAP2K1/INHBE/MYC/KLF4/FZD8/PIK3CA/IL6ST/IGF1R/FZD4/HOXA1/LIFR/PIK3CD/INHBB/HAND1/FZD5/SMAD1/FZD6/BMPR1B/MAPK13/JAK2/SMAD9/ACVR2A/FZD2/BMPR2/BMP4/ID2/JARID2/WNT4/SKIL/TBX3/WNT5A/FGF2/INHBA/MEIS1/IGF1/ID3/ID1/ID4/FZD7/WNT2/CTNNB1	134
KEGG	hsa04625	C-type lectin receptor signaling pathway	99/6848	104/8135	0.0004495	0.001583	0.0006785	CLEC7A/SYK/NLRP3/CD209/PTPN11/CLEC4M/MAPK11/PPP3CB/PPP3R2/CLEC4D/MAPK12/MAPK1/CALML4/AKT2/CLEC4E/KRAS/MAPK14/IL2/PLCG2/MAPK3/SRC/MAPK9/KSR1/RAF1/CALM2/IL12B/CLEC1B/AKT1/IKBKG/IKBKB/RHOA/PIK3R2/CCL17/CALML6/NFATC2/MAPKAPK2/CALM3/CASP8/CARD9/CCL22/ARHGEF12/AKT3/CALML3/FCER1G/CHUK/ITPR2/CALML5/MAPK8/RELA/RRAS/MDM2/IL10/PIK3CB/MRAS/RRAS2/ITPR3/PPP3CA/IKBKE/NFATC3/HRAS/PAK1/PIK3R3/IRF9/NRAS/BCL10/PIK3R1/CALM1/NFATC4/MALT1/STAT2/NFKB2/IL17D/TNF/PIK3CA/PYCARD/MAP3K14/PIK3CD/PRKCD/ITPR1/CASP1/STAT1/PLK3/MAPK10/IL12A/LSP1/MAPK13/CBLB/BCL3/IL23A/CYLD/RELB/NFATC1/NFKB1/PPP3R1/JUN/EGR3/EGR2/IRF1/NFKBIA	99
KEGG	hsa04724	Glutamatergic synapse	108/6848	114/8135	0.0004503	0.001583	0.0006785	GLS2/GRIN1/GRIK2/GRM8/GRIK5/GNAO1/GRIN3A/DLGAP1/PLCB2/GRM5/GNGT1/GRIA2/GRM1/GNG4/GRM7/GRIA4/CACNA1D/PPP3CB/PRKCG/PRKCB/SLC1A6/PRKACB/GRM2/KCNJ3/GRIN2C/PPP3R2/GRIK1/GNAS/PRKACA/GRM3/GRM4/MAPK1/DLG4/PLA2G4F/GRIK3/GRIN2B/SLC17A8/GRK2/GNG13/GNAI3/MAPK3/GNG3/SLC17A7/SLC1A7/GNB4/SLC38A3/PLD2/ADCY2/ADCY1/GNB2/GRIK4/GNGT2/PLCB3/ADCY9/SHANK1/SLC1A2/GRK3/GNG10/GRIN3B/ADCY5/GNG2/GRIN2D/GNAI2/SLC17A6/GNG8/PRKCA/PRKACG/ADCY3/GNG5/GNB1/GRM6/ITPR2/GNAQ/ADCY6/GLS/ADCY7/CACNA1A/ITPR3/PLA2G4C/TRPC1/PPP3CA/SHANK2/CACNA1C/GRIN2A/GNG7/GNG12/GLUL/SHANK3/SLC1A3/SLC38A1/HOMER3/GNB5/PLCB1/GRIA1/SLC1A1/HOMER2/ADCY8/SLC38A2/ITPR1/GRIA3/GNAI1/PLD1/GNG11/HOMER1/ADCY4/PLCB4/PPP3R1/PLA2G4A	108
KEGG	hsa04520	Adherens junction	69/6848	71/8135	0.0004803	0.001671	0.0007163	CTNNA3/AFDN/WAS/SMAD4/NECTIN1/ERBB2/CTNNA1/NECTIN4/MAPK1/SORBS1/CDH1/RAC3/FARP2/CTNND1/CSNK2B/EGFR/CSNK2A1/MAPK3/SRC/WASF3/TJP1/RAC1/RHOA/PTPRB/TGFBR2/ACP1/PTPN6/PTPRJ/CSNK2A2/NECTIN2/ACTB/FER/MAP3K7/CTNNA2/ACTN4/YES1/WASF2/CREBBP/LEF1/TCF7/SMAD3/VCL/ACTG1/TGFBR1/PARD3/LMO7/EP300/PTPRM/BAIAP2/SSX2IP/PTPRF/CDC42/RAC2/MET/NECTIN3/IGF1R/IQGAP1/TCF7L1/WASF1/NLK/FYN/ACTN1/SNAI2/INSR/WASL/SNAI1/TCF7L2/PTPN1/CTNNB1	69
KEGG	hsa04962	Vasopressin-regulated water reabsorption	44/6848	44/8135	0.0005007	0.001724	0.0007389	AQP4/AVP/AQP2/AVPR2/DCTN4/RAB11B/VAMP2/DCTN6/PRKACB/GNAS/RAB5C/PRKACA/CREB3L3/DYNC1I2/RAB11A/DCTN1/RAB5A/CREB1/DYNC1H1/DCTN2/DYNC1LI1/DYNC1I1/RAB5B/ARHGDIG/ADCY9/ARHGDIA/DYNC1LI2/DYNLL1/ARHGDIB/NSF/DCTN5/PRKACG/ADCY3/CREB3L1/CREB3/ADCY6/DYNLL2/DYNC2H1/CREB3L4/CREB3L2/DYNC2LI1/STX4/AQP3/CREB5	44
KEGG	hsa05014	Amyotrophic lateral sclerosis	328/6848	364/8135	0.0005587	0.001904	0.0008162	DNAH6/GRIN1/PRKN/NOS1/HAP1/DNAH3/TUBB1/GRIA2/ATF6/DCTN4/NDUFA11/DNAH11/NUP210/MAPK11/PPP3CB/HDAC6/KLC4/GPX5/COX8C/DCTN6/NRG3/KLC3/GPX2/DNAH1/DNAH12/ATP5F1C/NOS2/DNAH9/KIF5A/GRIN2C/PPP3R2/NRG2/PSMA8/NDUFS3/DNAH17/TP53/PSMB4/MAP1LC3B/ACTR1A/PSMD4/BCL2/MAPK12/DNAI2/NDUFA10/ATP5PB/UQCRFS1/NDUFC2/COX4I1/DCTN3/DNAH2/NDUFV1/BCL2L1/GRIN2B/SDHC/ATXN2L/NUP210L/SMCR8/ERBB4/ATP5PF/DNAH8/DCTN1/BECN1/RAB5A/MAPK14/BAD/COX6A1/UQCRC1/ATP5F1A/UQCR10/TNFRSF1A/PSMD6/NXF3/MATR3/RAB8A/NUP54/NDUFB4/DNAH14/SPG11/DNAH10/UQCRH/COX6B1/NDUFS4/TUBAL3/DCTN2/NDUFB8/KIF5B/POM121L2/PSMC2/NDUFB9/PSMB1/NRG4/COX7B2/RAB1A/HNRNPA1/NDUFB10/DNAI1/PRPH/AMBRA1/NDUFA13/GLE1/NDUFA8/COX5B/NUP214/ACTR10/COX8A/NDUFA9/PSMA1/NDUFB5/PSMC1/COX5A/RAC1/UBQLN3/DERL1/SEM1/SDHD/C9orf72/KLC1/VAPB/ATP5F1D/ACTR1B/ATP5PD/UQCR11/PSMB5/COX2/PIK3C3/PSMD9/SDHB/NDUFS7/TUBA8/WIPI2/NDUFB2/CHMP2B/ND4/NUP107/NUP43/ERN1/NUP133/NDUFA2/ALS2/ATP5F1B/NDUFA6/COX6B2/NUP160/NDUFB6/POM121/COX4I2/SLC1A2/ATG2B/NDUFB3/SETX/SOD1/ACTB/COX7A2L/NXT2/PSMD1/TUBA3C/NUP188/PSMD2/UQCRQ/NDUFA1/NUP155/NDUFA5/PSMD7/GRIN2D/COX7C/TUBB4A/PSMB2/UQCRB/DNAH5/NEFH/SDHA/PSMC6/NUP205/ANXA7/TUBA1A/DCTN5/PFN4/NDUFB7/SIGMAR1/TARDBP/NDC1/COX6C/NDUFB11/NDUFA12/RANBP2/NDUFA3/NUP85/CASP9/NXF1/NUP50/NDUFC1/NCBP1/PSMA2/ATP5F1E/PSMD13/NDUFS2/TPR/TBK1/RAE1/DNAL1/NDUFB1/ATG101/ATP5MC3/NDUFV2/UBQLN1/KLC2/TUBB/HNRNPA2B1/PSMD8/ATP5MC2/NDUFS5/NDUFA7/CCS/PIK3R4/ATXN2/NUP93/NUP98/PSMB6/PSMB7/PSMD3/PSMB3/NUP37/TANK/CASP3/FIG4/KIF5C/PSMC5/APAF1/CHCHD10/ACTG1/XBP1/ADRM1/PSMA3/CYC1/DNAL4/PSMA5/NRBF2/COX7A2/VCP/UBQLN4/ITPR3/PSMC3/NDUFS1/UBQLN2/PPP3CA/TRAF2/FUS/PINK1/NUP88/PSMC4/SEC13/PFN1/EIF2S1/DNAH7/NUP35/GRIN2A/PSMD11/NDUFS8/PSMD12/PFN2/ATG2A/GPX1/ATP5MC1/ATF4/NXT1/NUP62/TUBA1C/MCU/ND5/PSMA4/COX7B/HNRNPA3/TOMM40/DNALI1/BAX/DAXX/GPX8/VDAC1/PSMD14/PSMA7/NUP153/OPTN/MTOR/GPX3/SEH1L/NEFL/ANXA11/MAP2K6/NDUFV3/TUBA1B/GRIA1/TNF/NUP58/NRG1/TUBB4B/NEFM/MAP1LC3C/HSPA5/GPX7/EIF2AK3/TUBB3/RAB39B/CYCS/MAP1LC3A/ANG/ULK2/TUBB6/CASP1/TOMM40L/DDIT3/TUBA4A/PSMA6/CAT/MAPK13/COX7A1/NDUFA4/MAP2K3/NDUFA4L2/RB1CC1/ULK1/TUBB2A/WIPI1/ALYREF/PPP3R1/TNFRSF1B/TUBB2B/MAP3K5/BID	328
KEGG	hsa05031	Amphetamine addiction	67/6848	69/8135	0.0006445	0.002153	0.0009226	GRIN1/GRIN3A/ATF2/GRIA2/GRIA4/CACNA1D/PPP3CB/PRKCG/PRKCB/CAMK2B/SLC18A2/PRKACB/GRIN2C/PPP3R2/GNAS/CAMK4/PRKACA/CREB3L3/SLC18A1/CALML4/GRIN2B/CREB1/PPP1CC/CALM2/PPP1R1B/TH/PDYN/PPP1CB/CALML6/ATF6B/CALM3/SLC6A3/GRIN3B/ADCY5/PPP1CA/GRIN2D/PRKCA/CALML3/PRKACG/CREB3L1/CALML5/CREB3/CAMK2A/HDAC1/PPP3CA/CAMK2G/CACNA1C/GRIN2A/CALM1/ATF4/HDAC2/CREB3L4/STX1A/CREB3L2/GRIA1/DRD1/MAOA/CAMK2D/SIRT1/GRIA3/CREB5/ARC/MAOB/PPP3R1/JUN/FOS/FOSB	67
KEGG	hsa05211	Renal cell carcinoma	67/6848	69/8135	0.0006445	0.002153	0.0009226	PTPN11/PAK5/PAK4/PDGFB/TGFA/RAP1A/PAK6/ARAF/MAPK1/TFE3/AKT2/RAPGEF1/ELOB/EGLN2/KRAS/BAD/ARNT/MAPK3/RAF1/PAK2/AKT1/FLCN/RAC1/PIK3R2/TGFB1/GRB2/AKT3/PRCC/BRAF/MAP2K2/HIF1A/CRKL/ELOC/TGFB3/CREBBP/CRK/EPAS1/RAP1B/PIK3CB/CUL2/SOS2/EGLN3/VHL/FH/HRAS/PAK1/PIK3R3/EGLN1/SOS1/NRAS/CDKN1A/PIK3R1/EP300/MAP2K1/CDC42/MET/PAK3/PIK3CA/PIK3CD/VEGFA/HGF/GAB1/ETS1/TGFB2/ARNT2/JUN/SLC2A1	67
KEGG	hsa04723	Retrograde endocannabinoid signaling	138/6848	148/8135	0.0006853	0.002266	0.0009713	GNAO1/GABRB2/KCNJ5/PLCB2/GRM5/GNGT1/GABRA5/GRIA2/CNR1/GRM1/GABRG1/NDUFA11/CACNA1B/GNG4/MAPK11/GABRA1/GRIA4/CACNA1D/PRKCG/GABRA6/PRKCB/GABRR2/GABRA4/GABRG2/PRKACB/KCNJ3/NDUFS3/GABRR1/FAAH/GABRA2/PRKACA/MAPK12/NDUFA10/MAPK1/NDUFC2/NDUFV1/SLC17A8/MAPK14/GABRR3/SLC32A1/GNG13/GNAI3/MAPK3/NDUFB4/MAPK9/NDUFS4/GABRA3/NDUFB8/GNG3/CACNA1S/NDUFB9/SLC17A7/NDUFB10/GABRQ/GNB4/NDUFA13/NDUFA8/NDUFA9/NDUFB5/ADCY2/ADCY1/GNB2/GNGT2/PLCB3/KCNJ9/NDUFS7/NDUFB2/ADCY9/ND4/GABRD/NDUFA2/NDUFA6/NDUFB6/NDUFB3/GNG10/DAGLB/ADCY5/NDUFA1/GNG2/NDUFA5/GABRB1/DAGLA/CACNA1F/GNAI2/ABHD6/SLC17A6/GNG8/PRKCA/NDUFB7/PRKACG/ADCY3/NDUFB11/GNG5/GNB1/NDUFA12/GABRG3/NDUFA3/ITPR2/NDUFC1/GNAQ/MAPK8/NDUFS2/ADCY6/NDUFB1/NDUFV2/NDUFS5/NDUFA7/GABRB3/NAPEPLD/RIMS1/ADCY7/CACNA1A/ITPR3/NDUFS1/CACNA1C/GABRP/NDUFS8/GNG7/GNG12/ND5/GNB5/PLCB1/NDUFV3/GRIA1/ADCY8/ITPR1/GRIA3/GABRE/MAPK10/MGLL/MAPK13/GNAI1/KCNJ6/NDUFA4/GNG11/NDUFA4L2/ADCY4/PLCB4	138
KEGG	hsa05417	Lipid and atherosclerosis	197/6848	215/8135	0.0008414	0.002755	0.001181	NOX1/NLRP3/PLCB2/CYBB/CYP2A6/ATF6/FASLG/MAPK11/PTK2/PPP3CB/CAMK2B/CYP2C9/IRF3/ABCG1/PPP3R2/NCF4/APOB/RAP1A/TP53/ARHGEF1/CYP2C8/APOA4/BCL2/MAP2K7/MAPK12/IFNA6/MAPK1/TIRAP/SELP/CALML4/MIB2/AKT2/HSPA6/BCL2L1/NOS3/IFNB1/RXRB/TLR6/KRAS/MAPK14/BAD/TNFRSF1A/IFNA2/PDPK1/APOA1/MAPK3/SRC/ROCK2/TRAF6/MAPK9/VAV2/IFNA5/CALM2/CD40LG/TAB1/IL12B/RXRG/AKT1/IKBKG/IKBKB/VAV1/PLCG1/RAC1/MAP2K4/POU2F3/RHOA/PIK3R2/CALML6/CYP2J2/PLCB3/NFATC2/RXRA/IFNA1/IRAK1/CALM3/ERN1/HSP90AA1/IRAK4/CASP8/HSP90AB1/MAP3K7/IFNA14/AKT3/NCF1/POU2F1/PRKCA/CALML3/CYP2B6/IFNA16/CHUK/CASP9/IFNA8/CALML5/MAPK8/TBK1/CAMK2A/RELA/MYD88/RAP1B/CYP2A7/STAT3/MIB1/PIK3CB/TNFRSF10B/TANK/CASP3/HSPA4/APAF1/XBP1/LBP/CYP1A1/PPP3CA/TRAF2/IKBKE/GSK3B/NFATC3/HRAS/CAMK2G/PIK3R3/CYBA/OLR1/EIF2S1/IL18/VAV3/HSPA1A/NRAS/HSPD1/PIK3R1/CALM1/ATF4/ERO1A/POU2F2/LY96/BAX/MMP9/TAB2/TICAM2/CDC42/PLCB1/MAP2K6/TNF/PIK3CA/NCF2/CAMK2D/HSPA5/EIF2AK3/PYCARD/PIK3CD/CYCS/ITPR1/HSPA1L/FAS/TICAM1/TLR2/TRAF3/CASP1/IFNA21/CD40/VLDLR/CASP6/DDIT3/HSP90B1/MAPK10/IL12A/IRF7/LDLR/NFE2L2/MAPK13/JAK2/CASP7/PPARG/MAP2K3/TLR4/PLCB4/ABCA1/HSPA2/CD14/NFATC1/VCAM1/NFKB1/PPP3R1/CCL2/JUN/CD36/LYN/MAP3K5/BID/TNFSF10/CXCL1/FOS/CXCL3/CXCL8/SOD2/CXCL2/CCL5/NFKBIA/ICAM1	197
KEGG	hsa04512	ECM-receptor interaction	84/6848	88/8135	0.0009477	0.003055	0.00131	COL4A6/LAMB4/ITGB6/LAMA3/ITGB4/VWF/COL2A1/ITGA2B/DMP1/ITGA9/TNR/FREM2/ITGB1/LAMC3/COL4A5/SV2B/VTN/AGRN/COL9A1/FREM1/COL6A1/FRAS1/COL6A2/DSPP/GP6/GP9/ITGB7/ITGB3/FN1/CHAD/SV2C/GP5/COL4A3/DAG1/ITGA5/TNN/LAMA4/COL9A2/GP1BB/COL6A3/ITGA11/HSPG2/LAMC1/GP1BA/COL9A3/LAMB2/RELN/LAMA5/COL1A1/THBS3/NPNT/ITGAV/COL1A2/ITGA8/ITGA3/CD44/CD47/ITGA7/ITGB5/COL4A2/THBS2/LAMB1/ITGA4/SV2A/SPP1/LAMA1/LAMC2/ITGA1/COL4A1/SDC1/ITGB8/ITGA10/ITGA6/COMP/THBS1/SDC4/LAMA2/ITGA2/IBSP/COL4A4/CD36/TNC/COL6A6/LAMB3	84
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	93/6848	98/8135	0.0009605	0.003055	0.00131	PLCB2/KNG1/MAPK11/PRKCG/PRKCB/HTR2C/CAMK2B/PRKACB/ASIC4/TRPM8/ASIC5/GNAS/PRKACA/MAPK12/PLA2G4F/CALML4/TRPV3/MAPK14/PLCG2/SRC/PPP1CC/MAPK9/CALM2/PLA2G6/PLCG1/NTRK1/ADCY2/PRKCQ/ADCY1/PIK3R2/PPP1CB/ASIC2/IL1R1/ASIC3/CALML6/CYP2J2/PLCB3/ADCY9/PRKCE/CALM3/ADCY5/PPP1CA/TRPV4/ALOX12/PRKCA/CALML3/PRKACG/ADCY3/ITPR2/CALML5/GNAQ/MAPK8/CAMK2A/ADCY6/P2RY2/PIK3CB/ADCY7/ASIC1/ITPR3/PLA2G4C/CAMK2G/PIK3R3/PIK3R1/CALM1/TRPV1/PRKCH/PLCB1/MAP2K6/TRPV2/PIK3CA/CAMK2D/ADCY8/PIK3CD/PRKCD/ITPR1/IL1RAP/MAPK10/MAPK13/MAP2K3/PTGER4/F2RL1/ADCY4/PLCB4/HRH1/NGF/HTR2A/TRPA1/HTR2B/PTGER2/IGF1/PLA2G4A/BDKRB2/BDKRB1	93
KEGG	hsa05231	Choline metabolism in cancer	93/6848	98/8135	0.0009605	0.003055	0.00131	WAS/DGKB/PDGFB/DGKZ/SLC44A5/PRKCG/PRKCB/DGKE/TSC2/RPS6KB1/PCYT1B/PDGFRA/MAPK1/PLA2G4F/AKT2/DGKA/RAC3/SLC5A7/KRAS/EGFR/PDPK1/SLC44A4/EGF/MAPK3/RHEB/MAPK9/RAF1/SP1/AKT1/WASF3/DGKG/PIP5K1C/PLCG1/RAC1/PLD2/DGKQ/RPS6KB2/PIK3R2/SLC22A2/PIP5K1B/GRB2/AKT3/PCYT1A/MAP2K2/PRKCA/DGKH/HIF1A/GPCPD1/MAPK8/WASF2/PLPP2/SLC22A5/TSC1/DGKD/SLC44A1/PIK3CB/SLC22A1/SOS2/PLA2G4C/PIP5K1A/HRAS/SLC44A2/PIK3R3/PLPP3/SOS1/CHKB/NRAS/CHPT1/PDGFRB/PIK3R1/MAP2K1/CHKA/RALGDS/PDGFC/MTOR/RAC2/PIK3CA/LYPLA1/PLPP1/PIK3CD/WASF1/PDGFD/SLC44A3/EIF4EBP1/MAPK10/PLD1/SLC22A4/PDGFA/DGKI/JUN/SLC22A3/FOS/PLA2G4A	93
KEGG	hsa05100	Bacterial invasion of epithelial cells	74/6848	77/8135	0.001012	0.003188	0.001366	CTNNA3/SEPTIN2/CLTC/PTK2/DNM2/CTNNA1/ITGB1/CDH1/ILK/DOCK1/SEPTIN12/DNM3/ELMO2/BCAR1/CTTN/SRC/CBL/CLTA/RAC1/CAV3/RHOA/SHC1/PIK3R2/FN1/ELMO3/SEPTIN1/ACTB/ITGA5/CLTCL1/CTNNA2/SEPTIN8/SHC4/ACTR3/ACTR3B/CRKL/CD2AP/ARPC5/SHC3/ARPC2/WASF2/MAD2L2/CRK/VCL/PIK3CB/ACTG1/SEPTIN9/SEPTIN3/PXN/ARHGAP10/ACTR2/ARPC1A/PIK3R3/ACTR3C/ARPC1B/PIK3R1/ARPC3/ARPC4/ARPC5L/CDC42/MET/CAV1/SHC2/SEPTIN6/DNM1/PIK3CA/CAV2/SEPTIN11/PIK3CD/WASF1/GAB1/WASL/ELMO1/HCLS1/CTNNB1	74
KEGG	hsa04922	Glucagon signaling pathway	101/6848	107/8135	0.001056	0.003297	0.001413	PFKFB1/PLCB2/PCK1/ATF2/PPP3CB/PGAM2/CAMK2B/PRKACB/PPP3R2/GNAS/LDHAL6B/PHKG2/PRKACA/PPP4R3B/CREB3L3/GYS2/CALML4/AKT2/ACACA/PRKAA1/CREB1/G6PC2/CALM2/PRKAG1/AKT1/G6PC/SLC2A2/FBP2/PDE3B/GCG/PDHA1/ADCY2/PHKA2/CPT1A/CALML6/PLCB3/GCGR/CRTC2/CALM3/PKM/LDHB/G6PC3/PRKAB1/PFKL/PRKAA2/AKT3/PPP4R3A/PDHA2/LDHA/CALML3/PRKACG/CREB3L1/PPP4C/ITPR2/CALML5/GNAQ/CREB3/PGAM1/CREBBP/PYGB/CAMK2A/PRKAG3/PDHB/CPT1C/PYGM/LDHC/ITPR3/PPP3CA/PPARA/GYS1/CAMK2G/PRKAG2/PRKAB2/ACACB/PRMT1/PFKM/EP300/CALM1/ATF4/CREB3L4/PHKB/SIK2/CPT1B/CREB3L2/PYGL/PLCB1/PCK2/CAMK2D/SIK1/SIRT1/PHKG1/ITPR1/FOXO1/PHKA1/PFKP/CREB5/PLCB4/FBP1/PPARGC1A/PPP3R1/SLC2A1	101
KEGG	hsa05170	Human immunodeficiency virus 1 infection	194/6848	212/8135	0.001105	0.003417	0.001464	SKP1/GNAO1/PAK5/GNGT1/CFL1/PAK4/AP1B1/GNG4/FASLG/MAPK11/PTK2/PPP3CB/PRKCG/B2M/PRKCB/IRF3/PPP3R2/PTK2B/FBXW11/CGAS/CD3E/PAK6/AP1M2/RPS6KB1/BCL2/CUL1/CUL4A/MAP2K7/MAPK12/IFNA6/MAPK1/CCR5/CALML4/AKT2/BCL2L1/IFNB1/RAC3/ELOB/KRAS/MAPK14/BAD/AP1M1/BTRC/RNF7/CCNB3/CD3G/TNFRSF1A/IFNA2/PLCG2/GNG13/GNAI3/MAPK3/TRAF6/MAPK9/IFNA5/GNG3/RAF1/CALM2/PAK2/TAB1/AP1G2/CDC25C/AKT1/GNB4/IKBKG/IKBKB/CD4/PLCG1/TRADD/CUL5/RAC1/AP1G1/CD3D/RPS6KB2/PIK3R2/GNB2/CALML6/DCAF1/GNGT2/NFATC2/LIMK2/APOBEC3A/IFNA1/IRAK1/CALM3/IRAK4/CASP8/GNG10/MAP3K7/IFNA14/AKT3/DDB1/GNG2/GNAI2/GNG8/MAP2K2/APOBEC3C/PRKCA/CALML3/APOBEC3D/GNG5/CRKL/GNB1/IFNA16/CHUK/ELOC/CASP9/ITPR2/IFNA8/HLA-G/CALML5/GNAQ/MAPK8/ATM/TBK1/RELA/CRK/MYD88/RIPK1/PIK3CB/CASP3/ATR/APOBEC3F/CALR/ITPR3/AP1S3/PXN/PPP3CA/TRAF2/NFATC3/TRIM5/HRAS/PAK1/PIK3R3/AP1S2/LIMK1/PDIA3/NRAS/GNG7/GNG12/PIK3R1/CALM1/NFATC4/CUL4B/TRAF5/MAP2K1/CXCR4/BAX/FADD/TAB2/MTOR/HLA-F/AP1S1/RAC2/GNB5/PAK3/BAK1/MAP2K6/TNF/PIK3CA/CFL2/SAMHD1/PIK3CD/CYCS/APOBEC3G/GNA11/ITPR1/FAS/TLR2/HLA-E/CD247/IFNA21/CDK1/MAPK10/APOBEC3B/MAPK13/GNAI1/TAP1/CCNB1/GNG11/CCNB2/MAP2K3/TLR4/BST2/WEE1/TAP2/NFATC1/NFKB1/PPP3R1/JUN/TNFRSF1B/BID/FOS/NFKBIA	194
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	52/6848	53/8135	0.001161	0.003558	0.001525	ATP2B2/ESR1/AP2A1/PLCB2/ATP1A4/KLK2/CLTC/PRKCG/AP2M1/PRKCB/CALB1/DNM2/ATP2B3/PRKACB/AP2A2/FXYD2/GNAS/ATP1A2/ATP1B4/PRKACA/SLC8A3/ATP1B2/RAB11A/DNM3/PTH/ATP1A1/KLK1/CLTA/TRPV5/SLC8A2/AP2S1/AP2B1/ATP1B3/PLCB3/ADCY9/ATP1A3/PTH1R/CLTCL1/PRKCA/PRKACG/GNAQ/ADCY6/KL/SLC8A1/ATP2B4/PLCB1/DNM1/VDR/PLCB4/ATP1B1/ATP2B1/BDKRB2	52
KEGG	hsa04611	Platelet activation	116/6848	124/8135	0.001296	0.003934	0.001686	SYK/PLCB2/GNA13/BTK/P2RY1/P2RX1/FGA/MAPK11/F2/VWF/PRKACB/ROCK1/ITGA2B/GNAS/RAP1A/FGB/ARHGEF1/PIK3R5/PIK3CG/PRKACA/MAPK12/MAPK1/PLA2G4F/ITGB1/AKT2/NOS3/MAPK14/MYLK4/PLCG2/GNAI3/ARHGAP35/MAPK3/SRC/ROCK2/PPP1CC/FGG/PIK3R6/MYL12B/AKT1/MYLK2/TLN1/MYLK3/TBXAS1/ADCY2/GP6/RHOA/ADCY1/GP9/PIK3R2/PPP1CB/FCGR2A/P2RY12/ITGB3/PLCB3/ADCY9/SNAP23/TBXA2R/GP5/MYL12A/ACTB/ADCY5/ARHGEF12/AKT3/APBB1IP/PPP1CA/GNAI2/FCER1G/PRKACG/ADCY3/GP1BB/ITPR2/GUCY1A1/GNAQ/RASGRP2/ADCY6/PRKCZ/GP1BA/RAP1B/PIK3CB/ACTG1/ADCY7/TLN2/ITPR3/PLA2G4C/COL1A1/PTGIR/COL1A2/PIK3R3/PPP1R12A/ORAI1/PIK3R1/PRKG1/GUCY1B1/PRKCI/VASP/PLCB1/VAMP8/PIK3CA/ADCY8/FERMT3/PIK3CD/ITPR1/FYN/PTGS1/COL3A1/GUCY1A2/MYLK/MAPK13/GNAI1/PRKG2/ADCY4/PLCB4/ITGA2/LYN/RASGRP1/PLA2G4A	116
KEGG	hsa04929	GnRH secretion	62/6848	64/8135	0.001335	0.004016	0.001721	KCNJ5/PLCB2/CACNA1I/CACNA1D/PRKCG/ARRB2/PRKCB/ESR2/KCNN2/KCNJ3/KCNN3/KCNJ11/TRPC5/MAPK1/AKT2/KRAS/MAPK3/KISS1/RAF1/CACNA1S/AKT1/HCN3/CACNA1G/GABBR2/PIK3R2/CACNA1H/PLCB3/KCNJ9/KCNN1/HCN2/AKT3/CACNA1F/MAP2K2/PRKCA/GNRH2/ITPR2/CGA/GNAQ/GABBR1/PIK3CB/ITPR3/TRPC1/HRAS/PIK3R3/CACNA1C/GPER1/NRAS/ARRB1/PIK3R1/MAP2K1/GNRH1/TRPC4/PLCB1/PIK3CA/PIK3CD/GNA11/ITPR1/SPP1/KISS1R/KCNN4/KCNJ6/PLCB4	62
KEGG	hsa04670	Leukocyte transendothelial migration	107/6848	114/8135	0.001411	0.004209	0.001804	CTNNA3/PTPN11/AFDN/ITGAL/CYBB/CLDN18/MAPK11/PTK2/CLDN19/PRKCG/PRKCB/ROCK1/NCF4/PTK2B/JAM3/RAP1A/CTNNA1/CLDN3/MAPK12/SIPA1/ITGB1/MYL10/RAPGEF3/CLDN8/CTNND1/MAPK14/ITK/RHOH/CLDN6/PLCG2/GNAI3/ARHGAP35/BCAR1/CLDN7/ROCK2/MYL2/VAV2/CLDN10/MYLPF/MYL12B/CLDN5/VAV1/MMP2/PLCG1/ESAM/RAC1/RHOA/CLDN17/PIK3R2/CLDN15/CLDN4/F11R/CLDN2/MYL12A/ACTB/ITGAM/CTNNA2/CLDN9/NCF1/GNAI2/ACTN4/PRKCA/MYL5/CLDN16/CD99L2/CD99/RAP1B/VCL/PIK3CB/CLDN11/ACTG1/CLDN20/PXN/MYL9/PIK3R3/CYBA/VAV3/PIK3R1/PECAM1/CXCR4/MMP9/THY1/VASP/CDC42/RAC2/MSN/PIK3CA/NCF2/RAPGEF4/ARHGAP5/PIK3CD/EZR/ITGA4/JAM2/ACTN1/CXCL12/MAPK13/GNAI1/CDH5/ITGB2/RASSF5/CLDN14/VCAM1/CLDN23/CLDN1/CTNNB1/ICAM1	107
KEGG	hsa04140	Autophagy - animal	131/6848	141/8135	0.001446	0.004273	0.001831	PRAP1/ATG4B/STK11/RUBCN/AKT1S1/PRKACB/ATG5/LAMP1/HMGB1/TSC2/INS/MAP1LC3B/RPS6KB1/BCL2/PRKACA/MAPK1/ATG7/SNAP29/AKT2/IRS4/BCL2L1/SMCR8/ATG16L1/PRKAA1/BECN1/KRAS/BAD/PDPK1/ATG4D/RAB8A/MAPK3/TRAF6/RHEB/MAPK9/RAF1/MLST8/RAB1A/AKT1/CAMKK2/AMBRA1/RAB7A/RRAGA/C9orf72/ATG9B/PRKCQ/RPS6KB2/PIK3R2/PIK3C3/PPP2CB/WIPI2/MTMR14/ERN1/ATG3/ATG9A/ATG2B/RRAGC/MAP3K7/PRKAA2/MTMR3/AKT3/GABARAP/MAP2K2/PTEN/SH3GLB1/PRKACG/RPTOR/ATG16L2/HIF1A/ATG4A/ATG12/STX17/SUPT20H/MAPK8/TBK1/ATG101/RRAS/DAPK3/TSC1/PIK3R4/GABARAPL2/PIK3CB/UVRAG/MRAS/TANK/NRBF2/RRAS2/HRAS/LAMP2/PIK3R3/EIF2S1/PPP2CA/CTSL/ATG4C/ZFYVE1/NRAS/ATG2A/PIK3R1/RAB33B/RAB7B/MAP2K1/MTOR/VAMP8/PIK3CA/IGF1R/MAP1LC3C/EIF2AK3/EIF2AK4/RAB39B/PIK3CD/PRKCD/MAP1LC3A/ITPR1/IGBP1/ULK2/MTMR4/BNIP3/MAPK10/DAPK2/DEPTOR/RB1CC1/ULK1/CFLAR/RRAGB/WIPI1/RRAGD/DAPK1/GABARAPL1/IRS1/DDIT4/TP53INP2/IRS2	131
KEGG	hsa05163	Human cytomegalovirus infection	205/6848	225/8135	0.00149	0.004364	0.001871	GNAO1/PLCB2/GNA13/GNGT1/ATF2/GNG4/FASLG/MAPK11/PTK2/PPP3CB/PRKCG/B2M/PRKCB/IRF3/PRKACB/ROCK1/PPP3R2/PTK2B/CGAS/GNAS/TP53/ARHGEF1/TSC2/RPS6KB1/PRKACA/PDGFRA/MAPK12/CREB3L3/IFNA6/MAPK1/E2F2/CCR5/CALML4/AKT2/IFNB1/RAC3/KRAS/MAPK14/CREB1/CDKN2A/TNFRSF1A/IFNA2/EGFR/GNG13/GNAI3/IL10RA/BCAR1/MAPK3/SRC/RB1/ROCK2/RHEB/IFNA5/GNG3/RAF1/CALM2/ARHGEF11/CCR3/SP1/AKT1/ELK1/GNB4/IKBKG/IKBKB/CXCR2/TRADD/RAC1/ADCY2/RHOA/E2F1/ADCY1/RPS6KB2/PIK3R2/GNA12/GNB2/IL1R1/CALML6/GNGT2/ITGB3/PLCB3/NFATC2/ATF6B/ADCY9/IFNA1/CALM3/CASP8/GRB2/GNG10/PTGER1/ADCY5/IFNA14/ARHGEF12/AKT3/GNG2/GNAI2/GNG8/MAP2K2/PRKCA/CALML3/PRKACG/ADCY3/CREB3L1/GNG5/CRKL/GNB1/CDK4/IFNA16/CHUK/CASP9/ITPR2/IFNA8/HLA-G/CALML5/GNAQ/CREB3/TBK1/ADCY6/RELA/CRK/RIPK1/TSC1/MDM2/STAT3/PIK3CB/CASP3/SOS2/JAK1/CALR/ADCY7/E2F3/ITPR3/PXN/PPP3CA/TRAF2/GSK3B/NFATC3/HRAS/ITGAV/PIK3R3/PDIA3/SOS1/NRAS/GNG7/GNG12/CDKN1A/PIK3R1/CALM1/ATF4/NFATC4/TRAF5/CREB3L4/MAP2K1/CXCR4/BAX/FADD/MTOR/HLA-F/RAC2/GNB5/CREB3L2/PTGER3/MYC/BAK1/PLCB1/MAP2K6/TNF/PIK3CA/ADCY8/PIK3CD/CYCS/GNA11/ITPR1/FAS/CCR1/IL10RB/HLA-E/VEGFA/AKAP13/IFNA21/IL6R/CXCL12/EIF4EBP1/CDK6/MAPK13/GNAI1/TAP1/GNG11/CREB5/PTGER4/ADCY4/PLCB4/CCND1/TAP2/CCL4/NFATC1/NFKB1/PPP3R1/CCL2/PTGER2/CX3CL1/BID/CXCL8/CCL5/NFKBIA/CTNNB1	205
KEGG	hsa05217	Basal cell carcinoma	61/6848	63/8135	0.001542	0.004478	0.001919	HHIP/WNT10A/POLK/GLI1/WNT16/TP53/SUFU/WNT2B/WNT3/SHH/WNT6/WNT10B/APC2/WNT8B/WNT1/AXIN1/FZD9/WNT7B/PTCH2/WNT7A/FZD3/AXIN2/DVL3/DVL1/WNT8A/PTCH1/FZD1/APC/WNT9B/DVL2/KIF7/LEF1/TCF7/WNT11/SMO/WNT9A/GSK3B/WNT5B/CDKN1A/BAX/BAK1/FZD8/FZD4/TCF7L1/GLI2/FZD5/FZD6/GADD45G/FZD2/TCF7L2/BMP4/DDB2/WNT4/GLI3/GADD45A/WNT5A/GADD45B/FZD7/WNT2/BMP2/CTNNB1	61
KEGG	hsa04714	Thermogenesis	211/6848	232/8135	0.001634	0.004706	0.002017	ADRB3/DPF1/BMP8B/ACTL6B/ATF2/CNR1/BMP8A/PNPLA2/NDUFA11/SMARCB1/ADCY10/MAPK11/ARID1A/COX8C/AKT1S1/RPS6/ATP5F1C/PRKACB/NPPA/GNAS/NDUFS3/TSC2/UCP1/RPS6KB1/FGF21/PRKACA/MAPK12/CREB3L3/NDUFA10/ATP5PB/UQCRFS1/NDUFC2/SMARCD1/SIRT6/COX4I1/NDUFV1/SDHC/ACSL6/PRKAA1/ATP5PF/KRAS/MAPK14/CREB1/COX6A1/UQCRC1/NPR1/ATP5F1A/UQCR10/ATP5MG/COX15/KLB/NDUFB4/RHEB/UQCRH/COX6B1/NDUFS4/PLIN1/NDUFB8/MLST8/KDM1A/NDUFB9/COX7B2/NDUFB10/PRKAG1/NDUFA13/NDUFA8/COX5B/COX8A/NDUFA9/NDUFB5/GCG/COX5A/ATP5MF/ADCY2/SDHD/COX18/ADCY1/RPS6KB2/NPPB/CPT1A/ATP5F1D/ATP5PD/UQCR11/COX2/SDHB/LIPE/NDUFAF3/NDUFS7/COX19/NDUFB2/ADCY9/ND4/NDUFAF5/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/COX4I2/GRB2/NDUFB3/ACTB/COX7A2L/PRKAB1/NDUFAF1/ADCY5/PRKAA2/UQCRQ/NDUFA1/COA1/NDUFA5/COX7C/NDUFAF7/ATP5ME/UQCRB/FRS2/SDHA/COX10/SMARCA4/NDUFB7/PRKACG/RPTOR/ADCY3/CREB3L1/COX6C/NDUFB11/SMARCE1/NDUFA12/NDUFAF8/NDUFA3/COA3/NDUFC1/RPS6KA6/CREB3/ATP5F1E/SMARCC1/NDUFS2/RPS6KA1/ADCY6/NDUFB1/ATP5MC3/NDUFV2/PRKAG3/ATP5MC2/COX11/NDUFS5/NDUFA7/SMARCD3/TSC1/CPT1C/SMARCC2/SLC25A20/SOS2/ACTL6A/ACTG1/ADCY7/CYC1/COA6/COX7A2/COA4/NDUFS1/HRAS/RPS6KA2/PRKAG2/ARID1B/NDUFAF6/SMARCD2/PRKAB2/COA5/SOS1/COX16/NDUFS8/NRAS/COA7/PRDM16/ATP5MC1/CREB3L4/ND5/COX7B/PRKG1/CPT1B/COX17/MTOR/DPF3/CREB3L2/NDUFAF4/NDUFV3/ACSL1/SLC25A29/COX20/ADCY8/NDUFAF2/KDM3B/SMARCA2/ACSL5/MGLL/RPS6KA3/MAPK13/COX7A1/NDUFA4/CREB5/CPT2/PPARG/MAP2K3/PRKG2/NDUFA4L2/ADCY4/ACSL3/KDM3A/PPARGC1A/MAP3K5	211
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	37/6848	37/8135	0.001682	0.004762	0.002041	SCNN1G/ATP1A4/KCNJ1/PRKCG/PRKCB/SCNN1A/SLC9A3R2/FXYD2/INS/ATP1A2/ATP1B4/ATP1B2/MAPK1/KRAS/PDPK1/MAPK3/ATP1A1/FXYD4/SCNN1B/ATP1B3/PIK3R2/HSD11B2/ATP1A3/PRKCA/SFN/PIK3CB/PIK3R3/PIK3R1/PIK3CA/PIK3CD/NR3C2/INSR/SGK1/IRS1/NEDD4L/ATP1B1/IGF1	37
KEGG	hsa05216	Thyroid cancer	37/6848	37/8135	0.001682	0.004762	0.002041	POLK/TP53/RET/MAPK1/CDH1/RXRB/TFG/KRAS/MAPK3/RXRG/NCOA4/NTRK1/RXRA/PAX8/BRAF/MAP2K2/TPR/LEF1/TCF7/TPM3/HRAS/CCDC6/NRAS/CDKN1A/MAP2K1/BAX/MYC/BAK1/TCF7L1/GADD45G/PPARG/TCF7L2/CCND1/DDB2/GADD45A/GADD45B/CTNNB1	37
KEGG	hsa04213	Longevity regulating pathway - multiple species	60/6848	62/8135	0.00178	0.004967	0.002129	FOXA2/AKT1S1/PRKACB/ATG5/INS/RPS6KB1/PRKACA/AKT2/IRS4/HSPA6/PRKAA1/KRAS/PRKAG1/AKT1/ADCY2/CLPB/ADCY1/RPS6KB2/PIK3R2/ADCY9/SOD1/PRKAB1/ADCY5/PRKAA2/AKT3/PRKACG/RPTOR/ADCY3/EIF4EBP2/ADCY6/PRKAG3/HDAC1/PIK3CB/ADCY7/HRAS/PRKAG2/PRKAB2/PIK3R3/HSPA1A/NRAS/PIK3R1/FOXO3/HDAC2/MTOR/PIK3CA/IGF1R/ADCY8/CRYAB/SIRT1/PIK3CD/HSPA1L/INSR/FOXO1/CAT/ADCY4/HSPA2/IRS1/IGF1/IRS2/SOD2	60
KEGG	hsa04912	GnRH signaling pathway	88/6848	93/8135	0.001785	0.004967	0.002129	GNRHR/PLCB2/MAPK11/CACNA1D/PRKCB/CAMK2B/PRKACB/PTK2B/GNAS/PRKACA/MAP2K7/MAPK12/MAPK1/PLA2G4F/CALML4/KRAS/MAPK14/EGFR/MAPK3/SRC/MAPK9/RAF1/CACNA1S/CALM2/ELK1/MMP2/FSHB/MAP2K4/PLD2/ADCY2/ADCY1/CALML6/PLCB3/ADCY9/CALM3/GRB2/ADCY5/CACNA1F/MAP2K2/PRKCA/CALML3/GNRH2/PRKACG/ADCY3/ITPR2/CGA/MAP3K2/MAP3K3/CALML5/GNAQ/MAPK8/CAMK2A/ADCY6/MAPK7/SOS2/ADCY7/ITPR3/MAP3K1/PLA2G4C/HRAS/CAMK2G/CACNA1C/SOS1/NRAS/CALM1/ATF4/MMP14/MAP2K1/GNRH1/MAP3K4/CDC42/PLCB1/MAP2K6/CAMK2D/ADCY8/PRKCD/GNA11/ITPR1/MAPK10/MAPK13/PLD1/MAP2K3/ADCY4/PLCB4/HBEGF/JUN/EGR1/PLA2G4A	88
KEGG	hsa04979	Cholesterol metabolism	49/6848	50/8135	0.001852	0.005113	0.002191	VAPA/APOA2/ABCB11/APOH/STARD3/APOB/ANGPTL3/APOA4/CETP/APOC3/LRP2/VDAC3/LRPAP1/APOA1/APOC2/LPA/VDAC2/OSBPL5/VAPB/SCARB1/ABCG8/ANGPTL8/LRP1/APOC1/STAR/TSPO/SOAT2/LPL/LCAT/LDLRAP1/PLTP/VDAC1/SOAT1/SORT1/LIPA/LIPC/CYP27A1/NPC1/NPC2/PCSK9/LDLR/ANGPTL4/APOE/ABCA1/CYP7A1/NCEH1/MYLIP/LIPG/CD36	49
KEGG	hsa05142	Chagas disease	96/6848	102/8135	0.001913	0.005226	0.00224	GNAO1/PPP2R2D/PLCB2/KNG1/PPP2R2C/FASLG/MAPK11/PPP2R1A/SMAD2/NOS2/CD3E/GNAS/C1QC/MAPK12/MAPK1/AKT2/IFNB1/TLR6/MAPK14/IL2/CD3G/TNFRSF1A/C1QA/GNAI3/MAPK3/TRAF6/MAPK9/IFNG/IL12B/AKT1/IKBKG/IKBKB/MAP2K4/CD3D/ADCY1/ACE/PIK3R2/TGFBR2/PLCB3/PPP2CB/IRAK1/TGFB1/IRAK4/CASP8/PPP2R1B/AKT3/GNAI2/PPP2R2A/C1QB/GNAL/CHUK/TGFB3/GNAQ/MAPK8/RELA/MYD88/IL10/PIK3CB/CALR/TGFBR1/PIK3R3/PPP2CA/PIK3R1/FADD/GNA15/IFNGR1/PLCB1/PPP2R2B/TNF/PIK3CA/PIK3CD/GNA11/FAS/TICAM1/TLR2/CD247/SERPINE1/MAPK10/IL12A/MAPK13/GNAI1/TLR4/PLCB4/CFLAR/IFNGR2/TGFB2/GNA14/C3/NFKB1/CCL2/JUN/FOS/CXCL8/CCL5/BDKRB2/NFKBIA	96
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	202/6848	222/8135	0.001924	0.005226	0.00224	RANBP3/VAC14/ITGAL/HLA-DQB1/ATF2/HLA-DOA/JAK3/HLA-DQA1/TERT/PPP3CB/IL2RG/B2M/ANAPC11/ELK4/SLC25A31/SMAD4/ANAPC5/SMAD2/IL2RA/PRKACB/GPS2/PPP3R2/CD3E/ANAPC1/ANAPC2/TP53/PRKACA/CREB3L3/MAPK1/E2F2/AKT2/BCL2L1/CRTC1/ANAPC7/KRAS/CREB1/IL1R2/IL2/LTBR/CDKN2A/CD3G/TNFRSF1A/VDAC3/SPI1/MAPK3/RB1/MAPK9/KAT5/AKT1/ELK1/IKBKG/IKBKB/TCF3/CDC16/TBP/VDAC2/SLC25A6/IL2RB/CD4/TLN1/MMP7/LCK/ANAPC15/MAP2K4/ADCY2/ANAPC4/CD3D/E2F1/ADCY1/PIK3R2/IL1R1/TGFBR2/NFATC2/ATF6B/ADCY9/CRTC2/CDK2/TGFB1/CDC27/ADCY5/PTTG2/AKT3/ANAPC13/TNFRSF13C/MAP2K2/PTEN/PRKACG/CDC26/ADCY3/CREB3L1/STAT5B/TSPO/SLC25A5/CDK4/CHUK/MAD1L1/TGFB3/BUB3/FDPS/MAP3K3/HLA-G/DLG1/KAT2A/CREB3/MAPK8/ATM/CREBBP/XIAP/CRTC3/ADCY6/RELA/SMAD3/CCND3/ANAPC16/TBPL1/SLC25A4/PIK3CB/RANBP1/TRRAP/SRF/JAK1/ATR/ANAPC10/CALR/ADCY7/TLN2/E2F3/TGFBR1/MAP3K1/PPP3CA/NFATC3/HRAS/PIK3R3/NRP1/NRAS/CDKN1A/PIK3R1/EP300/POLB/ATF4/NFATC4/RAN/XPO1/CREB3L4/MAP2K1/BAX/VDAC1/HLA-DPA1/HLA-F/NFYB/CREB3L2/NFKB2/MYC/TNF/CCND2/PIK3CA/CHEK2/CDC23/CCNE1/ADCY8/MAP3K14/PIK3CD/HLA-E/CCNA2/CD40/CDC20/ETS2/CCNA1/MAPK10/PTTG1/CDKN2C/HLA-DRA/CDKN2B/KAT2B/MSX2/FOSL1/ETS1/CREB5/CCNB2/ESPL1/MSX1/ADCY4/BUB1B/CCNE2/CCND1/MAD2L1/RELB/ITGB2/TGFB2/ZFP36/NFATC1/IL15RA/NFKB1/PPP3R1/JUN/SLC2A1/FOS/EGR1/EGR2/IL15/NFKBIA/ICAM1	202
KEGG	hsa03030	DNA replication	36/6848	36/8135	0.002	0.005388	0.002309	RNASEH2C/POLE/POLD4/RPA4/LIG1/RFC1/SSBP1/RNASEH1/POLD1/POLD2/RPA1/RPA3/RNASEH2B/PRIM2/POLE4/POLA1/RFC3/POLE3/RFC5/MCM6/MCM7/DNA2/MCM4/RPA2/POLA2/POLD3/PCNA/RFC2/MCM5/MCM3/RNASEH2A/MCM2/POLE2/FEN1/RFC4/PRIM1	36
KEGG	hsa04932	Non-alcoholic fatty liver disease	143/6848	155/8135	0.002045	0.005464	0.002342	NDUFA11/FASLG/MAPK11/COX8C/NDUFS3/INS/MAPK12/NDUFA10/UQCRFS1/PKLR/NDUFC2/COX4I1/AKT2/NDUFV1/SDHC/GSK3A/PRKAA1/MAP3K11/MAPK14/COX6A1/UQCRC1/UQCR10/TNFRSF1A/NDUFB4/MAPK9/UQCRH/COX6B1/NDUFS4/MLXIPL/NDUFB8/NDUFB9/COX7B2/ADIPOQ/NDUFB10/PRKAG1/AKT1/IKBKB/NDUFA13/NDUFA8/COX5B/COX8A/MLX/NDUFA9/NDUFB5/MLXIP/COX5A/RAC1/SDHD/PIK3R2/UQCR11/COX2/SDHB/RXRA/NDUFS7/NDUFB2/TGFB1/ADIPOR1/ERN1/NDUFA2/NDUFA6/COX6B2/NDUFB6/CASP8/COX4I2/BCL2L11/NDUFB3/COX7A2L/PRKAB1/PRKAA2/AKT3/UQCRQ/NDUFA1/NDUFA5/COX7C/UQCRB/SDHA/NDUFB7/COX6C/NDUFB11/NDUFA12/NDUFA3/NDUFC1/MAPK8/CYP2E1/ADIPOR2/NDUFS2/SREBF1/NDUFB1/RELA/NDUFV2/PRKAG3/NDUFS5/NDUFA7/PIK3CB/CASP3/XBP1/CYC1/COX7A2/NDUFS1/TRAF2/GSK3B/PPARA/LEP/PRKAG2/PRKAB2/PIK3R3/EIF2S1/NDUFS8/PIK3R1/ATF4/COX7B/BAX/CDC42/NDUFV3/TNF/NR1H3/PIK3CA/LEPR/EIF2AK3/PIK3CD/CYCS/FAS/IL6R/DDIT3/INSR/MAPK10/MAPK13/CEBPA/ITCH/CASP7/COX7A1/NDUFA4/PPARG/SOCS3/NDUFA4L2/IRS1/NFKB1/JUN/MAP3K5/BID/FOS/IRS2/CXCL8	143
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	48/6848	49/8135	0.002163	0.005688	0.002438	HKDC1/CYB5RL/CYB5R3/HK3/CHIT1/GALT/CHIA/CYB5R4/RENBP/GNPDA2/GPI/HEXB/TSTA3/FPGT/MPI/NAGK/FCSK/AMDHD2/HEXA/PGM1/HK1/PMM2/NANP/PMM1/CYB5R1/UAP1L1/CMAS/NPL/GNPDA1/GALK2/GFPT1/GNE/GMPPA/GALK1/UGP2/UGDH/GALE/PGM3/NANS/GNPNAT1/PGM2/HK2/CYB5R2/UAP1/GMPPB/GMDS/UXS1/GFPT2	48
KEGG	hsa05030	Cocaine addiction	48/6848	49/8135	0.002163	0.005688	0.002438	GRIN1/GRIN3A/RGS9/ATF2/GRIA2/DRD2/SLC18A2/PRKACB/GRM2/GRIN2C/GNAS/PRKACA/GRM3/CREB3L3/DLG4/SLC18A1/GRIN2B/CREB1/GPSM1/GNAI3/PPP1R1B/CDK5R1/TH/PDYN/ATF6B/SLC6A3/GRIN3B/ADCY5/GRIN2D/GNAI2/PRKACG/CREB3L1/CREB3/RELA/CDK5/GRIN2A/ATF4/CREB3L4/CREB3L2/DRD1/MAOA/GNAI1/CREB5/MAOB/BDNF/NFKB1/JUN/FOSB	48
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	94/6848	100/8135	0.002417	0.006308	0.002704	NOX1/COL4A6/PLCB2/CYBB/MAPK11/PRKCB/SMAD4/SMAD2/BCL2/MAPK12/MAPK1/AKT2/NOS3/COL4A5/KRAS/MAPK14/PLCG2/MAPK3/MAPK9/AKT1/PLCD1/MMP2/PLCG1/RAC1/PIK3R2/TGFBR2/PLCB3/PRKCE/FN1/TGFB1/COL4A3/AKT3/PRKCA/DIAPH1/STAT5B/CDK4/TGFB3/MAPK8/PLCD3/VEGFB/PRKCZ/RELA/SMAD3/STAT3/PIK3CB/CASP3/TGFBR1/COL1A1/HRAS/COL1A2/PIK3R3/NRAS/PIK3R1/PLCD4/BAX/CDC42/PLCB1/TNF/PIK3CA/COL4A2/PIK3CD/PRKCD/VEGFA/STAT1/COL3A1/SERPINE1/MAPK10/FOXO1/COL4A1/MAPK13/JAK2/VEGFC/PLCE1/PLCB4/CCND1/VEGFD/THBD/TGFB2/CDKN1B/F3/NFATC1/NOX4/VCAM1/NFKB1/AGT/CCL2/AGTR1/JUN/COL4A4/EGR1/CXCL8/PIM1/EDN1/ICAM1	94
KEGG	hsa04917	Prolactin signaling pathway	67/6848	70/8135	0.00261	0.006756	0.002896	ESR1/ELF5/TNFSF11/MAPK11/ESR2/SOCS7/CSN2/LHCGR/INS/MAPK12/MAPK1/AKT2/KRAS/MAPK14/CYP17A1/MAPK3/SRC/MAPK9/RAF1/AKT1/PRLR/SLC2A2/PRL/GALT/TH/SHC1/PIK3R2/GRB2/AKT3/SOCS4/SHC4/MAP2K2/STAT5B/SHC3/CGA/TNFRSF11A/MAPK8/RELA/STAT3/PIK3CB/SOS2/SOCS5/GSK3B/HRAS/PIK3R3/SOS1/NRAS/PIK3R1/FOXO3/MAP2K1/SHC2/CCND2/SOCS6/PIK3CA/PIK3CD/STAT1/SOCS1/MAPK10/MAPK13/JAK2/SOCS2/CISH/SOCS3/CCND1/NFKB1/FOS/IRF1	67
KEGG	hsa00514	Other types of O-glycan biosynthesis	46/6848	47/8135	0.002945	0.007567	0.003243	ST3GAL3/ST6GAL2/POFUT2/GALNTL5/GALNT8/RFNG/POMT2/GALNT9/COLGALT2/GALNTL6/MFNG/PLOD3/GALNT5/GALNT14/POMT1/OGT/B4GALT2/POFUT1/B4GALT3/GALNT12/COLGALT1/GALNT17/B4GALT1/GALNT11/GALNT10/GALNT6/GALNT16/GALNT7/C1GALT1C1/GALNT2/C1GALT1C1L/ST6GAL1/GALNT4/GXYLT2/LFNG/GXYLT1/EOGT/GALNT18/POGLUT1/B3GLCT/GALNT3/XXYLT1/GALNT13/GALNT1/C1GALT1/GALNT15	46
KEGG	hsa03018	RNA degradation	75/6848	79/8135	0.00301	0.007674	0.003289	CNOT1/CNOT3/BTG4/CNOT6L/EDC4/CNOT4/EDC3/XRN2/EXOSC1/LSM8/PARN/WDR61/MTREX/EXOSC10/CNOT7/TOB2/CNOT10/CNOT2/LSM3/EXOSC7/PFKL/PABPC1/DIS3/ENO3/TTC37/LSM1/PNLDC1/DHX36/EXOSC5/PATL1/CNOT8/LSM7/EXOSC8/PABPC4/LSM5/DCPS/TENT4A/EXOSC9/NUDT16/CNOT6/EXOSC6/DCP1A/EXOSC3/C1D/DCP2/EXOSC2/XRN1/PAN3/PFKM/HSPD1/LSM4/PABPC1L/MPHOSPH6/ENO1/LSM6/CNOT9/LSM2/PABPC3/EXOSC4/PNPT1/PABPC4L/TOB1/TENT4B/DIS3L/PABPC5/ENO2/ZCCHC7/PAN2/DCP1B/PFKP/HSPA9/BTG1/DDX6/BTG3/BTG2	75
KEGG	hsa04936	Alcoholic liver disease	131/6848	142/8135	0.003165	0.008009	0.003433	IL17RC/FASLG/MAPK11/IL17A/ADH6/TAB3/IRF3/ADH7/C1QC/MAP2K7/MAPK12/IFNA6/FABP1/TIRAP/AKT2/ACACA/IFNB1/PRKAA1/LPIN3/MAPK14/TNFRSF1A/IFNA2/C1QA/ADH1A/TRAF6/ADH4/MAPK9/IFNA5/TAB1/IL12B/ADIPOQ/PRKAG1/AKT1/IKBKG/CAMKK2/IKBKB/TRADD/SCD5/MAP2K4/LPIN2/CPT1A/IFNA1/IRAK1/ADIPOR1/IRAK4/CASP8/C5AR1/PRKAB1/MAP3K7/PRKAA2/IFNA14/FASN/AKT3/IL17RA/C1QB/MLYCD/ACADVL/IFNA16/CHUK/IFNA8/ACADM/MAPK8/CYP2E1/ADIPOR2/SCD/TBK1/LEF1/SREBF1/TCF7/RELA/TRA2B/PRKAG3/MYD88/RIPK1/CPT1C/CASP3/ADH5/C2/LBP/LPIN1/IKBKE/GSK3B/PPARA/PRKAG2/PRKAB2/ACACB/FOXO3/TRA2A/ALDH9A1/LY96/C3AR1/FADD/TAB2/CPT1B/MAP2K6/C5/TNF/SIRT1/MAP3K14/TCF7L1/ACOX1/FAS/TICAM1/TRAF3/ALDH2/ALDH7A1/ALDH3A2/IFNA21/ALDH1B1/MAPK10/FOXO1/IL12A/MAPK13/MAP2K3/TLR4/TCF7L2/CCND1/ADH1C/CD14/ADH1B/PPARGC1A/C3/NOX4/NFKB1/MAP3K5/CXCL1/CXCL3/CXCL8/CXCL2/NFKBIA/CTNNB1	131
KEGG	hsa03050	Proteasome	45/6848	46/8135	0.003435	0.008626	0.003697	PSMF1/PSMA8/PSMB4/PSMD4/PSMD6/IFNG/PSMC2/PSMB1/PSMA1/PSMC1/SEM1/PSMB5/PSMD9/PSMD1/PSMD2/PSMD7/PSMB2/PSMC6/PSMA2/PSMD13/PSMD8/PSME3/PSME1/PSMB6/PSMB7/PSMD3/PSMB3/PSME4/PSMC5/ADRM1/PSMA3/PSMA5/PSMC3/PSMC4/PSMB8/PSMD11/PSMD12/PSMA4/PSMD14/PSMA7/POMP/PSMB9/PSMA6/PSME2/PSMB10	45
KEGG	hsa05160	Hepatitis C	144/6848	157/8135	0.003788	0.009442	0.004047	PPP2R2D/CLDN18/PPP2R2C/FASLG/PPP2R1A/CLDN19/IRF3/YWHAE/TP53/CLDN3/ARAF/IFNA6/MAPK1/E2F2/AKT2/IFNB1/CLDN8/YWHAQ/KRAS/BAD/CLDN6/TNFRSF1A/IFNA2/EGFR/EGF/MAPK3/CLDN7/RB1/TRAF6/IFNG/IFNA5/RAF1/CLDN10/AKT1/IKBKG/IKBKB/CD81/CLDN5/TRADD/E2F1/CLDN17/TYK2/PIK3R2/CLDN15/SCARB1/PPP2CB/RXRA/IFNA1/CDK2/CLDN4/CASP8/GRB2/CLDN2/PPP2R1B/IFNA14/AKT3/EIF2AK1/CLDN9/PPP2R2A/BRAF/MAP2K2/CLDN16/CDK4/IFNA16/CHUK/CASP9/YWHAG/IFNA8/PIAS1/YWHAB/TBK1/MAVS/RELA/PSME3/RIPK1/STAT3/PIK3CB/CASP3/CLDN11/SOS2/JAK1/APAF1/CLDN20/E2F3/TRAF2/IKBKE/GSK3B/PPARA/HRAS/RNASEL/PIK3R3/IRF9/EIF2S1/PPP2CA/SOS1/NRAS/EIF2AK2/EIF3E/CDKN1A/PIK3R1/MAP2K1/BAX/FADD/STAT2/YWHAH/MYC/BAK1/PPP2R2B/IFNAR1/TNF/NR1H3/PIK3CA/OAS2/EIF2AK3/EIF2AK4/PIK3CD/CYCS/FAS/TLR3/TICAM1/TRAF3/STAT1/IFNA21/IRF7/LDLR/CDK6/OAS3/SOCS3/DDX58/CCND1/OAS1/CFLAR/IFIT1/MX1/RSAD2/MX2/CLDN14/NFKB1/IFNAR2/CLDN23/BID/CLDN1/NFKBIA/CTNNB1	144
KEGG	hsa04923	Regulation of lipolysis in adipocytes	54/6848	56/8135	0.004179	0.01034	0.004431	ADRB3/PNPLA2/ADRB1/PRKACB/TSHB/NPPA/GNAS/INS/PRKACA/AKT2/IRS4/TSHR/NPR1/GNAI3/PLIN1/AKT1/PDE3B/ADCY2/ADCY1/AQP7/PIK3R2/LIPE/ADCY9/ADCY5/AKT3/GNAI2/PRKACG/ADCY3/CGA/ADCY6/PIK3CB/ADCY7/NPY/PIK3R3/ABHD5/PIK3R1/NPY1R/PRKG1/ADRB2/PTGER3/PIK3CA/ADORA1/ADCY8/PIK3CD/INSR/PTGS1/MGLL/GNAI1/PRKG2/ADCY4/PLAAT3/IRS1/FABP4/IRS2	54
KEGG	hsa04660	T cell receptor signaling pathway	97/6848	104/8135	0.00433	0.01063	0.004558	PTPRC/PAK5/CTLA4/PAK4/MAPK11/PPP3CB/CD8B/CARD11/IL4/CD28/PPP3R2/CD3E/PAK6/ZAP70/MAP2K7/MAPK12/MAPK1/AKT2/KRAS/MAPK14/GRAP2/ITK/IL2/CD3G/PDPK1/CD8A/MAPK3/MAPK9/IFNG/VAV2/RAF1/PAK2/CD40LG/AKT1/IKBKG/IKBKB/VAV1/CD4/PLCG1/LCK/TEC/CD3D/RHOA/PRKCQ/PIK3R2/NFATC2/PDCD1/PTPN6/GRB2/MAP3K7/AKT3/MAP2K2/CDK4/CHUK/ICOS/DLG1/MAPK8/RELA/LAT/IL10/PIK3CB/NFKBIB/SOS2/PPP3CA/GSK3B/NFATC3/HRAS/PAK1/PIK3R3/VAV3/SOS1/NRAS/BCL10/PIK3R1/MALT1/MAP2K1/NCK1/CDC42/PAK3/NCK2/TNF/PIK3CA/MAP3K14/PIK3CD/FYN/CD247/MAPK10/MAPK13/CBLB/NFATC1/NFKB1/PPP3R1/JUN/RASGRP1/NFKBIE/FOS/NFKBIA	97
KEGG	hsa04915	Estrogen signaling pathway	127/6848	138/8135	0.004673	0.01139	0.004883	ESR1/GNAO1/KCNJ5/PLCB2/ATF2/OPRM1/GRM1/KRT40/TGFA/KRT25/ESR2/PRKACB/KCNJ3/GNAS/RARA/BCL2/PRKACA/CREB3L3/MAPK1/POMC/CALML4/AKT2/HSPA6/NOS3/KRAS/CREB1/KRT13/EGFR/GNAI3/MAPK3/SRC/RAF1/CALM2/KRT24/SP1/KRT23/AKT1/TFF1/MMP2/KRT20/ADCY2/SHC1/KRT37/GABBR2/ADCY1/PIK3R2/KRT12/CALML6/KRT17/PLCB3/KCNJ9/KRT32/ATF6B/ADCY9/CALM3/KRT9/HSP90AA1/HSP90AB1/GRB2/ADCY5/KRT35/AKT3/GNAI2/SHC4/MAP2K2/CALML3/PRKACG/ADCY3/CREB3L1/FKBP4/SHC3/KRT33B/ITPR2/CALML5/KRT15/GNAQ/CREB3/KRT31/KRT16/ADCY6/PGR/KRT14/KRT10/GABBR1/PIK3CB/KRT36/SOS2/EBAG9/ADCY7/ITPR3/KRT27/HRAS/PIK3R3/GPER1/SOS1/HSPA1A/NCOA1/NRAS/PIK3R1/CALM1/ATF4/CREB3L4/MAP2K1/MMP9/CREB3L2/PLCB1/SHC2/NCOA3/PIK3CA/FKBP5/ADCY8/PIK3CD/PRKCD/ITPR1/HSPA1L/HSP90B1/GNAI1/KCNJ6/CREB5/KRT18/ADCY4/PLCB4/HSPA2/HBEGF/JUN/KRT19/FOS	127
KEGG	hsa05020	Prion disease	245/6848	273/8135	0.004803	0.01156	0.004955	GRIN1/GRIN3A/CYBB/ATF2/TUBB1/RYR3/NDUFA11/CACNA1B/MAPK11/RYR2/C8A/CACNA1D/PPP3CB/KLC4/COX8C/KLC3/SLC25A31/ATP5F1C/PRKACB/KIF5A/GRIN2C/PPP3R2/NCF4/C1QC/PSMA8/NDUFS3/PSMB4/NCAM1/PSMD4/PRKACA/MAPK12/CREB3L3/NDUFA10/ATP5PB/UQCRFS1/MAPK1/NDUFC2/COX4I1/NDUFV1/HSPA6/GRIN2B/SDHC/ATP5PF/MAPK14/CSNK2B/CREB1/BAD/COX6A1/UQCRC1/ATP5F1A/UQCR10/PSMD6/VDAC3/C1QA/CSNK2A1/MAPK3/NDUFB4/MAPK9/UQCRH/COX6B1/NDUFS4/TUBAL3/NDUFB8/CACNA1S/KIF5B/PSMC2/NDUFB9/PSMB1/COX7B2/NDUFB10/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/C8B/COX8A/NDUFA9/PSMA1/NDUFB5/PSMC1/COX5A/RAC1/CAV3/SEM1/SDHD/PIK3R2/KLC1/ATP5F1D/RYR1/ATP5PD/UQCR11/PSMB5/COX2/PSMD9/SDHB/NDUFS7/TUBA8/ATF6B/NDUFB2/ND4/CSNK2A2/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/COX4I2/NDUFB3/SOD1/COX7A2L/PSMD1/TUBA3C/GRIN3B/PSMD2/UQCRQ/NDUFA1/NDUFA5/PSMD7/GRIN2D/NCF1/CACNA1F/COX7C/TUBB4A/PSMB2/C1QB/UQCRB/SDHA/PSMC6/TUBA1A/NDUFB7/PRKACG/CREB3L1/COX6C/NDUFB11/C6/SLC25A5/C7/NDUFA12/NDUFA3/CASP9/ITPR2/NDUFC1/PSMA2/CREB3/MAPK8/ATP5F1E/C8G/PSMD13/C9/NDUFS2/NDUFB1/LAMC1/ATP5MC3/NDUFV2/KLC2/TUBB/PSMD8/ATP5MC2/NDUFS5/NDUFA7/NCAM2/SLC25A4/PSMB6/PSMB7/PIK3CB/NOTCH1/PSMD3/PSMB3/PRNP/CASP3/KIF5C/PSMC5/APAF1/ADRM1/PSMA3/CYC1/PSMA5/COX7A2/ITPR3/PSMC3/NDUFS1/PPP3CA/GSK3B/PSMC4/PIK3R3/CYBA/EIF2S1/CACNA1C/HSPA1A/GRIN2A/PSMD11/NDUFS8/PSMD12/STIP1/PIK3R1/ATP5MC1/ATF4/CREB3L4/TUBA1C/MCU/ND5/PSMA4/COX7B/BAX/VDAC1/PPIF/PSMD14/PSMA7/RAC2/CREB3L2/CAV1/NDUFV3/C5/TUBA1B/TNF/TUBB4B/PIK3CA/NCF2/HSPA5/EIF2AK3/TUBB3/CAV2/PIK3CD/CYCS/PRKCD/ITPR1/HSPA1L/FYN/TUBB6/DDIT3/TUBA4A/MAPK10/PSMA6/MAPK13/COX7A1/NDUFA4/CREB5/NDUFA4L2/TUBB2A/HSPA2/PPP3R1/TUBB2B/EGR1/CCL5	245
KEGG	hsa04350	TGF-beta signaling pathway	88/6848	94/8135	0.004811	0.01156	0.004955	SKP1/BMP7/BMP8B/BMP8A/ACVR1B/PPP2R1A/SMAD4/SMAD2/ROCK1/DCN/RPS6KB1/CUL1/CHRD/MAPK1/AMHR2/HAMP/HJV/LEFTY2/NODAL/MAPK3/IFNG/SP1/TFDP1/RHOA/RPS6KB2/TGFBR2/E2F4/RBL1/PPP2CB/TGFB1/BMP5/ZFYVE9/PPP2R1B/SMURF1/SMAD6/TGFB3/LEFTY1/CREBBP/SMAD3/ACVR2B/SMAD5/ACVR1C/TGFBR1/ZFYVE16/ACVR1/PPP2CA/BMPR1A/FBN1/EP300/PITX2/E2F5/INHBE/NEO1/MYC/TNF/NOG/TGIF1/INHBB/GREM1/SMAD1/FMOD/NBL1/LTBP1/THSD4/TGIF2/GDF5/CDKN2B/BMPR1B/SMAD9/ACVR2A/RGMB/BMPR2/BMP4/ID2/SMURF2/BMP6/RGMA/THBS1/TGFB2/BAMBI/GREM2/FST/INHBA/SMAD7/ID3/ID1/ID4/BMP2	88
KEGG	hsa00230	Purine metabolism	118/6848	128/8135	0.005419	0.01284	0.005502	PDE4C/PDE1B/PDE4A/ADCY10/ENTPD2/NT5M/ENPP3/ENTPD3/NT5C1B/PDE11A/PDE2A/PDE6G/AMPD1/ALLC/AK8/NT5DC4/NPR1/PDE6C/PDE9A/PDE6A/NUDT5/PRPS1L1/GUCY2C/PDE6H/NUDT9/PDE6B/PDE3B/ADCY2/CANT1/ADCY1/NT5C1A/GDA/ADCY9/GUCY2F/GMPS/GUK1/PDE4D/ADCY5/AK7/ENTPD5/ADSL/XDH/NME7/NT5C/ADCY3/PAPSS1/NT5E/APRT/NT5C2/AK3/GUCY1A1/GART/PDE3A/DGUOK/NME3/HDDC2/PDE10A/PDE6D/ADCY6/PRUNE1/PGM1/ENTPD6/AK2/NME4/PDE8A/AK1/ADCY7/ATIC/PRPS2/NUDT16/FHIT/IMPDH2/ITPA/AMPD2/GUCY2D/DCK/AK9/GMPR2/ENTPD4/NTPCR/PFAS/PDE7A/HDDC3/IMPDH1/GUCY1B1/ENPP1/ADK/PRPS1/NPR2/PAICS/PDE1C/ADPRM/HPRT1/ENTPD1/ADCY8/ADA2/ADA/NUDT2/PDE8B/RRM2B/NME6/PPAT/PGM2/GMPR/AMPD3/GUCY1A2/NME1/ENPP4/LACC1/PAPSS2/PDE5A/ADCY4/PNP/PDE7B/PDE1A/RRM2/AK5/PDE4B	118
KEGG	hsa04380	Osteoclast differentiation	118/6848	128/8135	0.005419	0.01284	0.005502	NOX1/SYK/LILRA5/BTK/CALCR/TNFSF11/MAPK11/SIRPB1/LILRA1/PPP3CB/LILRA2/PPP3R2/NCF4/CAMK4/LILRB5/TYROBP/MAP2K7/LILRA3/MAPK12/MAPK1/LILRB4/SIRPG/AKT2/IFNB1/LILRB3/FCGR2B/MAPK14/CREB1/TNFRSF1A/PLCG2/SPI1/MAPK3/TRAF6/MAPK9/IFNG/TAB1/AKT1/IKBKG/IKBKB/CSF1R/LCK/LILRA4/RAC1/TEC/OSCAR/TYK2/PIK3R2/FCGR2A/IL1R1/TGFBR2/ITGB3/NFATC2/TGFB1/GRB2/MAP3K7/FCGR3B/AKT3/NCF1/TREM2/FCGR2C/CTSK/CHUK/TNFRSF11A/MAPK8/CSF1/RELA/LILRB2/PIK3CB/JAK1/ACP5/TGFBR1/FOSL2/PPP3CA/TRAF2/JUND/PIK3R3/IRF9/CYBA/FHL2/PIK3R1/MAP2K1/TAB2/STAT2/NFKB2/IFNGR1/MAP2K6/IFNAR1/TNF/PIK3CA/BLNK/NCF2/MAP3K14/PIK3CD/FYN/STAT1/SOCS1/MAPK10/MAPK13/FOSL1/SIRPA/PPARG/SOCS3/GAB2/CYLD/IFNGR2/RELB/JUNB/TGFB2/MITF/TNFRSF11B/NFATC1/NFKB1/PPP3R1/IFNAR2/JUN/FOS/FOSB/NFKBIA	118
KEGG	hsa00020	Citrate cycle (TCA cycle)	30/6848	30/8135	0.005647	0.01322	0.005666	IDH3G/PCK1/OGDH/CS/IDH3B/SDHC/ACO2/DLST/SUCLG1/OGDHL/DLD/SUCLA2/PDHA1/SDHD/SDHB/MDH1/PDHA2/SDHA/DLAT/MDH2/IDH2/PDHB/ACLY/SUCLG2/FH/IDH3A/ACO1/PCK2/IDH1/PC	30
KEGG	hsa04210	Apoptosis	125/6848	136/8135	0.00566	0.01322	0.005666	FASLG/PRF1/SPTAN1/TP53/BCL2/MAPK1/AKT2/CASP10/CTSW/BCL2L1/SEPTIN4/KRAS/BAD/DIABLO/TNFRSF1A/PDPK1/MAPK3/MAPK9/TUBAL3/RAF1/SPTA1/AKT1/IKBKG/IKBKB/TRADD/IL3RA/TP53AIP1/PARP3/NTRK1/CAPN1/PIK3R2/CTSV/GZMB/TUBA8/ERN1/CASP8/DFFA/BCL2L11/HTRA2/DAB2IP/ACTB/TUBA3C/AKT3/MAP2K2/CAPN2/TUBA1A/CTSK/CHUK/ENDOG/CASP9/ITPR2/PARP1/AIFM1/MAPK8/ATM/PIDD1/XIAP/RELA/RIPK1/PIK3CB/TNFRSF10B/CASP3/APAF1/ACTG1/CASP2/ITPR3/TRAF2/HRAS/PARP2/PIK3R3/EIF2S1/CTSL/NRAS/CTSO/PIK3R1/HRK/DFFB/ATF4/MAP2K1/TUBA1C/BBC3/LMNA/BIRC2/BAX/FADD/DAXX/BAK1/TUBA1B/TNF/MCL1/PIK3CA/CTSF/EIF2AK3/MAP3K14/PIK3CD/CYCS/ITPR1/LMNB2/FAS/BIRC5/CASP6/GADD45G/DDIT3/CSF2RB/TUBA4A/MAPK10/CASP7/PTPN13/CTSH/CFLAR/NGF/GADD45A/NFKB1/CTSS/TRAF1/CTSZ/JUN/MAP3K5/PMAIP1/CTSC/BID/TNFSF10/FOS/GADD45B/NFKBIA	125
KEGG	hsa04115	p53 signaling pathway	69/6848	73/8135	0.006339	0.0147	0.006302	TP73/SHISA5/TP53/TSC2/BCL2/BCL2L1/COP1/CDKN2A/SIVA1/RCHY1/SERPINB5/TP53AIP1/RPRM/MDM4/CDK2/CASP8/PTEN/CDK4/SFN/CASP9/ATM/PIDD1/CCND3/AIFM2/MDM2/EI24/TNFRSF10B/CASP3/ATR/APAF1/GTSE1/CDKN1A/TP53I3/BBC3/BAX/SIAH1/PERP/CCND2/CHEK2/IGFBP3/CCNE1/CYCS/FAS/RRM2B/SESN2/SESN3/SESN1/GADD45G/CDK1/SERPINE1/STEAP3/CDK6/ZMAT3/GORAB/CCNB1/CCNB2/PPM1D/CCNE2/CCND1/RRM2/DDB2/THBS1/CCNG2/GADD45A/IGF1/PMAIP1/BID/GADD45B/CD82	69
KEGG	hsa00310	Lysine degradation	60/6848	63/8135	0.006552	0.01499	0.006425	PRDM7/KMT2B/KMT5C/KMT2D/BBOX1/PRDM9/SMYD1/SETDB1/EHMT1/ECHS1/DLST/DLD/ACAT1/TMLHE/CAMKMT/COLGALT2/PIPOX/HADHA/PLOD3/PLOD1/GCDH/NSD3/KMT5A/DOT1L/SETD2/SETD1B/AADAT/ASH1L/SUV39H1/SMYD2/KMT2A/COLGALT1/EZH1/DHTKD1/HYKK/KMT5B/SETMAR/EHHADH/NSD2/SETDB2/KMT2C/SETD7/PRDM16/HADH/ALDH9A1/PHYKPL/SMYD3/ACAT2/SUV39H2/PRDM2/ALDH2/EZH2/ALDH7A1/ALDH3A2/KMT2E/ALDH1B1/PRDM6/MECOM/AASS/PLOD2	60
KEGG	hsa03250	Viral life cycle - HIV-1	60/6848	63/8135	0.006552	0.01499	0.006425	SMARCB1/PDCD6IP/SUPT5H/PPIA/MLLT1/CCR5/VPS4A/TSG101/PIN1/NELFE/AFF4/SUPT4H1/CPSF7/TNPO3/CD4/NELFCD/HGS/APOBEC3A/NELFA/CHMP4A/CHMP6/CCNT2/NELFB/CPSF6/FURIN/MAP1A/APOBEC3C/MAP1S/APOBEC3D/RANBP2/KAT2A/VPS4B/CREBBP/ELL/PSIP1/FEZ1/CDK9/ELL3/APOBEC3F/BICD1/CHMP4B/BICD2/TRIM5/ELL2/MAP1B/SERINC3/EP300/RAN/CCNT1/XPO1/CXCR4/NUP153/SAMHD1/APOBEC3G/APOBEC3B/KAT2B/BST2/MLLT3/MX1/MX2	60
KEGG	hsa04662	B cell receptor signaling pathway	77/6848	82/8135	0.006641	0.01509	0.006467	SYK/LILRA5/CD22/DAPP1/BTK/CD79B/CD79A/LILRA1/PPP3CB/PRKCB/INPP5D/LILRA2/CARD11/PPP3R2/CR2/LILRB5/LILRA3/MAPK1/LILRB4/AKT2/RAC3/LILRB3/FCGR2B/KRAS/PIK3AP1/PLCG2/MAPK3/VAV2/RAF1/RASGRP3/AKT1/IKBKG/IKBKB/CD19/CD81/VAV1/LILRA4/RAC1/PIK3R2/NFATC2/PTPN6/GRB2/AKT3/MAP2K2/CHUK/RELA/CD72/INPPL1/LILRB2/PIK3CB/NFKBIB/SOS2/PPP3CA/GSK3B/NFATC3/HRAS/PIK3R3/VAV3/SOS1/NRAS/BCL10/PIK3R1/MALT1/MAP2K1/IFITM1/RAC2/PIK3CA/BLNK/PIK3CD/NFATC1/NFKB1/PPP3R1/JUN/LYN/NFKBIE/FOS/NFKBIA	77
KEGG	hsa04137	Mitophagy - animal	68/6848	72/8135	0.007161	0.01616	0.006926	PRKN/RPS27A/BCL2L13/UBB/UBA52/TAX1BP1/ATG5/UBC/TP53/MAP1LC3B/TFE3/BCL2L1/BECN1/KRAS/CSNK2B/CSNK2A1/SRC/FIS1/MAPK9/TOMM7/SP1/AMBRA1/RAB7A/MFN2/ATG9B/E2F1/TBC1D17/MFN1/CSNK2A2/ATG9A/RHOT2/CALCOCO2/FUNDC1/GABARAP/HIF1A/PGAM5/MAPK8/USP15/TBK1/RELA/RRAS/USP8/GABARAPL2/TFEB/MRAS/RRAS2/PINK1/HRAS/NBR1/USP30/NRAS/ATF4/RAB7B/FOXO3/TBC1D15/BNIP3L/CITED2/OPTN/MAP1LC3C/EIF2AK3/RHOT1/MAP1LC3A/BNIP3/MAPK10/ULK1/GABARAPL1/MITF/JUN	68
KEGG	hsa03013	Nucleocytoplasmic transport	100/6848	108/8135	0.007208	0.01616	0.006926	IPO8/NUP210/AAAS/SUMO3/SAP18/EEF1A1/UBE2I/SUMO2/SENP2/RANGAP1/NUP210L/IPO9/KPNA6/NXF3/NMD3/NUP54/SUMO1/THOC1/POM121L2/THOC5/XPO4/TNPO3/SRRM1/GLE1/NUP42/NUP214/RANBP17/IPO13/IPO11/PYM1/EEF1A2/NUP107/NUP43/NUP133/DDX19A/NUP160/POM121/NXT2/NUP188/EIF4A3/NUP155/RNPS1/XPO6/TNPO2/CSE1L/NUP205/CASC3/NDC1/XPO7/RANBP2/NCBP2/DDX19B/NUP85/NXF1/NUP50/NCBP1/MAGOH/TPR/THOC7/PHAX/ACIN1/RAE1/THOC2/IPO7/PNN/UPF3A/NUP93/NUP98/NUP37/UPF1/KPNA5/AHCTF1/XPO5/THOC6/TNPO1/KPNA4/TMEM33/NUP88/SEC13/KPNA1/NUP35/UPF2/RBM8A/SNUPN/IPO5/RAN/XPO1/KPNA3/NXT1/NUP62/XPOT/KPNB1/NUP153/SEH1L/NUP58/IPO4/KPNA2/UPF3B/MAGOHB/ALYREF	100
KEGG	hsa03440	Homologous recombination	40/6848	41/8135	0.007366	0.01629	0.006984	TOP3B/TOP3A/RAD51B/XRCC3/UIMC1/BABAM2/BABAM1/SEM1/MRE11/MUS81/XRCC2/POLD4/SYCP3/RPA4/SSBP1/RAD51D/POLD1/RAD52/POLD2/RAD50/RPA1/ATM/RAD51/RPA3/BLM/BRCC3/BRCA1/TOPBP1/RAD51C/BRCA2/BARD1/BRIP1/EME1/RAD54B/RPA2/RAD54L/POLD3/ABRAXAS1/RBBP8/NBN	40
KEGG	hsa05219	Bladder cancer	40/6848	41/8135	0.007366	0.01629	0.006984	ERBB2/TP53/ARAF/MAPK1/E2F2/CDH1/UPK3A/KRAS/CDKN2A/EGFR/EGF/MAPK3/SRC/RB1/RAF1/FGFR3/MMP2/E2F1/BRAF/MAP2K2/CDK4/DAPK3/MDM2/E2F3/HRAS/NRAS/CDKN1A/MAP2K1/MMP9/RPS6KA5/MYC/RASSF1/VEGFA/DAPK2/TYMP/CCND1/DAPK1/THBS1/HBEGF/CXCL8	40
KEGG	hsa00564	Glycerophospholipid metabolism	91/6848	98/8135	0.008249	0.01813	0.007769	GPD1/DGKB/DGKZ/DGKE/PTDSS2/PLA2G12B/TAZ/ETNPPL/PLA2G2D/PCYT1B/PLD4/PLA2G10/AGPAT1/PLA2G4F/DGKA/PNPLA7/LPIN3/PNPLA6/ETNK2/PLA2G2F/MBOAT7/PHOSPHO1/CDS2/DGKG/PLA2G6/PLA2G3/LPCAT2/GPAT4/PLB1/LPIN2/PLD2/DGKQ/PLD3/GNPAT/LPCAT3/AGPAT2/CHAT/PLA2G1B/CDIPT/PCYT1A/PTDSS1/LCLAT1/DGKH/ACHE/AGPAT3/GPCPD1/PGS1/PCYT2/ETNK1/PLPP2/LYPLA2/DGKD/PISD/LCAT/PEMT/PLA2G12A/PLA2G4C/LPIN1/MBOAT2/PLA2G15/PLPP3/CHKB/LPCAT1/CHPT1/LPCAT4/CRLS1/GPD1L/CHKA/PLPP5/SELENOI/CDS1/CEPT1/ADPRM/PLA2G5/GPAM/LYPLA1/PLPP1/PLA1A/LPGAT1/AGPAT5/AGPAT4/GPAT2/MBOAT1/PLD1/GPAT3/GPD2/PLAAT3/PLPP4/PLA2G2A/DGKI/PLA2G4A	91
KEGG	hsa01200	Carbon metabolism	106/6848	115/8135	0.008436	0.01842	0.007893	AGXT/TKFC/HKDC1/ALDOB/IDH3G/TKTL1/PGAM2/OGDH/CS/IDH3B/H6PD/TKTL2/PKLR/SDHC/ECHS1/ACO2/GLYCTK/HAO2/HK3/SDS/DLST/GAPDH/SUCLG1/OGDHL/PRPS1L1/DLD/ACAT1/SUCLA2/GOT2/FBP2/ACADS/GOT1L1/PDHA1/SDHD/PGK2/GLUD2/SDHB/ME2/MDH1/PGLS/PKM/G6PD/PCCB/GLDC/PFKL/ADPGK/ESD/ENO3/GPI/PDHA2/SDHA/SHMT1/DLAT/ACSS2/ALDOA/GPT/RPE/PGAM1/GLUD1/MDH2/IDH2/IDNK/HK1/ME3/PDHB/SDSL/ADH5/SUCLG2/TALDO1/PRPS2/PGK1/FH/HIBCH/IDH3A/MMUT/PFKM/PGD/TKT/GCSH/SHMT2/ENO1/ALDH6A1/RPIA/ACO1/ALDOC/PRPS1/GPT2/PCCA/GOT1/IDH1/ACAT2/CPS1/AMT/ENO2/ACOX1/MCEE/PHGDH/ME1/HK2/PC/PFKP/CAT/PSPH/RGN/FBP1/PSAT1	106
KEGG	hsa05033	Nicotine addiction	39/6848	40/8135	0.008568	0.01858	0.007965	GRIN1/GABRB2/GRIN3A/GABRA5/GRIA2/GABRG1/CACNA1B/GABRA1/GRIA4/GABRA6/GABRR2/GABRA4/GABRG2/CHRNA6/GRIN2C/CHRNA4/GABRR1/GABRA2/CHRNB2/GRIN2B/SLC17A8/GABRR3/SLC32A1/GABRA3/SLC17A7/GABRQ/GABRD/GRIN3B/GRIN2D/GABRB1/SLC17A6/GABRG3/GABRB3/CACNA1A/GABRP/GRIN2A/GRIA1/GRIA3/GABRE	39
KEGG	hsa05415	Diabetic cardiomyopathy	183/6848	203/8135	0.008914	0.01921	0.008233	PLCB2/CYBB/NDUFA11/MAPK11/RYR2/REN/PRKCG/PRKCB/COX8C/CAMK2B/SLC25A31/SMAD2/ATP5F1C/NCF4/ATP2A1/SLC2A4/NDUFS3/INS/TNNI3/MAPK12/NDUFA10/ATP5PB/UQCRFS1/GYS2/NDUFC2/COX4I1/AKT2/NDUFV1/NOS3/SDHC/ATP5PF/ATP2A3/MAPK14/CMA1/COX6A1/PTPA/UQCRC1/ATP5F1A/UQCR10/VDAC3/NDUFB4/GAPDH/PPP1CC/MAPK9/UQCRH/COX6B1/NDUFS4/NDUFB8/NDUFB9/SP1/COX7B2/NDUFB10/AKT1/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/MMP2/COX8A/NDUFA9/NDUFB5/COX5A/RAC1/PDHA1/ATP2A2/SDHD/PLN/ACE/PIK3R2/PPP1CB/ATP5F1D/TGFBR2/ATP5PD/UQCR11/COX2/PLCB3/SDHB/NDUFS7/NDUFB2/ND4/TGFB1/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/COX4I2/G6PD/NDUFB3/COX7A2L/AKT3/UQCRQ/NDUFA1/PPP1CA/NDUFA5/NCF1/COX7C/PDHA2/UQCRB/SDHA/PTEN/PRKCA/NDUFB7/MPC1/COX6C/NDUFB11/SLC25A5/NDUFA12/NDUFA3/TGFB3/PARP1/NDUFC1/MAPK8/ATP5F1E/NDUFS2/CAMK2A/PRKCZ/NDUFB1/RELA/ATP5MC3/SMAD3/NDUFV2/PDHB/ATP5MC2/NDUFS5/NDUFA7/SLC25A4/PIK3CB/CYC1/COX7A2/TGFBR1/GSR/NDUFS1/GSK3B/PPARA/GYS1/COL1A1/CAMK2G/COL1A2/PIK3R3/CYBA/NDUFS8/PIK3R1/ATP5MC1/PDK2/ND5/GFPT1/COX7B/VDAC1/MMP9/PPIF/CPT1B/MTOR/RAC2/PLCB1/MPC2/NDUFV3/PIK3CA/PDK4/NCF2/CAMK2D/PIK3CD/PRKCD/TBC1D4/PDK3/INSR/COL3A1/MAPK10/MAPK13/COX7A1/NDUFA4/CPT2/NDUFA4L2/PLCB4/TGFB2/IRS1/NFKB1/AGT/AGTR1/GFPT2/CD36/SLC2A1	183
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	90/6848	97/8135	0.009164	0.01962	0.008409	PTPRC/SCIN/SYK/WAS/CFL1/PRKCG/PRKCB/INPP5D/DNM2/RPS6KB1/MAPK1/PLA2G4F/AKT2/DOCK1/FCGR2B/PLCG2/MAPK3/VAV2/RAF1/AKT1/WASF3/VAV1/PLA2G6/PIP5K1C/PLCG1/RAC1/PLD2/RPS6KB2/PIK3R2/FCGR2A/LIMK2/PRKCE/PIP5K1B/SPHK2/FCGR3B/AKT3/NCF1/ACTR3/PRKCA/ACTR3B/CRKL/ARPC5/ARPC2/WASF2/GSN/PLPP2/BIN1/CRK/LAT/INPPL1/PIK3CB/PLA2G4C/MARCKS/PIP5K1A/ACTR2/ARPC1A/PAK1/PIK3R3/LIMK1/PLPP3/ACTR3C/ARPC1B/VAV3/PIK3R1/MAP2K1/ARPC3/ARPC4/ARPC5L/VASP/ASAP1/CDC42/RAC2/ASAP2/PIK3CA/ARF6/CFL2/PLPP1/PIK3CD/PRKCD/WASF1/MARCKSL1/PLD1/ASAP3/GAB2/AMPH/HCK/SPHK1/LYN/MYO10/PLA2G4A	90
KEGG	hsa05418	Fluid shear stress and atherosclerosis	127/6848	139/8135	0.009227	0.01963	0.008413	NOX1/PDGFB/MAPK11/PTK2/SUMO3/ITGA2B/TP53/BCL2/MAP2K7/MAPK12/SUMO2/CALML4/AKT2/NOS3/RAC3/PRKAA1/MAPK14/IL1R2/TNFRSF1A/SRC/MAPK9/IFNG/SUMO1/CALM2/AKT1/IKBKG/IKBKB/MMP2/RAC1/MAP2K4/CAV3/RHOA/GSTA1/PIK3R2/IL1R1/CALML6/GSTP1/ITGB3/CALM3/TXN2/HSP90AA1/HSP90AB1/ACTB/MAP3K7/PRKAA2/AKT3/NCF1/TRPV4/PIAS4/CALML3/GSTA3/CHUK/KEAP1/GSTM4/CALML5/MAPK8/PRKCZ/MGST3/NPPC/RELA/ACVR2B/PIK3CB/MAPK7/GPC1/ACTG1/GSTO2/GSTM1/MEF2C/ITGAV/PIK3R3/ACVR1/CYBA/SDC2/CTSL/TXN/BMPR1A/PIK3R1/PECAM1/CALM1/GSTA4/MGST1/ARHGEF2/KDR/GSTO1/MMP9/RAC2/NQO1/MAP2K6/CAV1/TNF/PIK3CA/NCF2/CAV2/PIK3CD/VEGFA/HSP90B1/MAPK10/NFE2L2/MAP2K5/BMPR1B/MAPK13/SDC1/ACVR2A/DUSP1/BMPR2/ASS1/MGST2/CDH5/BMP4/KLF2/THBD/GSTM3/GSTM5/SDC4/HMOX1/MEF2A/PLAT/PDGFA/VCAM1/NFKB1/CCL2/JUN/MAP3K5/FOS/CTNNB1/EDN1/ICAM1	127
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	27/6848	27/8135	0.009485	0.01992	0.00854	ST3GAL3/ABO/FUT9/FUT6/B3GALT1/FUT2/FUT7/FUT1/FUT5/B3GNT4/FUT3/B3GNT3/B3GALT5/ST3GAL4/GCNT2/B4GALT2/B4GALT3/B4GALT1/FUT4/B3GNT5/B4GALT4/B3GNT2/B3GALNT1/A4GALT/ST3GAL6/B3GALT2/ST8SIA1	27
KEGG	hsa04966	Collecting duct acid secretion	27/6848	27/8135	0.009485	0.01992	0.00854	SLC4A1/ATP6V1C2/ATP6V0C/ATP6V0A1/ATP6V1F/ATP6V0D2/CLCNKB/ATP6V0E1/ATP6V1B1/ATP4B/ATP6V0D1/ATP6V0A4/ATP6V1G3/ATP6V1D/ATP6V1E1/CA2/TCIRG1/ATP4A/ATP6V1G2/ATP6V1E2/ATP6V1C1/ATP6V1A/ATP6V1G1/ATP6V1B2/ATP6V0A2/ATP6V0E2/SLC12A7	27
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	175/6848	194/8135	0.009792	0.02044	0.008761	SYK/RPS27A/GNGT1/CD200R1/PDGFB/CD86/GNG4/MAPK11/PPP3CB/UBB/UBA52/IRF3/PPP3R2/UBC/TP53/PIK3R5/PIK3CG/MAP1LC3B/MAP2K7/MAPK12/IFNA6/MAPK1/E2F2/CCR5/CALML4/AKT2/IFNB1/BECN1/KRAS/MAPK14/CREB1/ANGPT2/TNFRSF1A/IFNA2/PLCG2/GNG13/MAPK3/SRC/RB1/MAPK9/IFNA5/GNG3/RAF1/CALM2/PIK3R6/CCR3/AKT1/GNB4/IKBKG/IKBKB/PLCG1/TRADD/RAC1/MAP2K4/E2F1/TYK2/PIK3R2/GNB2/CCR8/CALML6/GNGT2/PIK3C3/NFATC2/IFNA1/MAPKAPK2/CALM3/ATG3/CASP8/GNG10/IFNA14/AKT3/GNG2/CCR4/GNG8/MAP2K2/CALML3/HIF1A/GNG5/GNB1/CDK4/IFNA16/CHUK/CASP9/ITPR2/IFNA8/HLA-G/CALML5/MAPK8/CREBBP/TBK1/LEF1/TCF7/RELA/STAT3/PIK3CB/CASP3/JAK1/E2F3/ITPR3/PPP3CA/TRAF2/IKBKE/GSK3B/NFATC3/HRAS/PIK3R3/IRF9/NRAS/GNG7/EIF2AK2/GNG12/CDKN1A/PIK3R1/EP300/CALM1/NFATC4/MAP2K1/BAX/FADD/MTOR/HLA-F/GNB5/STAT2/MYC/IFNGR1/BAK1/MAP2K6/IFNAR1/PIK3CA/IL6ST/MAP1LC3C/TCF7L1/PIK3CD/CYCS/MAP1LC3A/ITPR1/FAS/CCR1/TLR3/TICAM1/TRAF3/HLA-E/VEGFA/STAT1/IFNA21/RCAN1/MAPK10/IRF7/CDK6/MAPK13/JAK2/GNG11/PREX1/TCF7L2/CCND1/HCK/ZFP36/NFATC1/C3/FGF2/NFKB1/PPP3R1/IFNAR2/JUN/LYN/BID/CLEC2B/CXCL1/FOS/CXCL3/CXCL8/CXCL2/NFKBIA/CTNNB1/ICAM1	175
KEGG	hsa04630	JAK-STAT signaling pathway	147/6848	162/8135	0.01022	0.0212	0.009085	CSF2RA/IL5RA/EPOR/IL22/THPO/PTPN11/GFAP/CRLF2/GH1/JAK3/CSF3R/PDGFB/IL12RB1/EPO/IL23R/IL2RG/SOCS7/IL2RA/IL4/BCL2/PDGFRA/IFNA6/IL9R/GH2/STAT6/STAM2/AKT2/IL22RA2/BCL2L1/IFNB1/IFNLR1/IFNL1/IL20/IL2/IL21/IFNA2/EGFR/EGF/IL10RA/MPL/IFNG/IFNA5/RAF1/IL12B/CSH2/AKT1/IL9/IL2RB/IFNL2/PRLR/IL3RA/PRL/OSM/CNTFR/IFNL3/TYK2/PIK3R2/IL21R/IL22RA1/PTPN6/CSH1/IFNA1/GRB2/PIAS2/IFNA14/AKT3/IL13RA1/SOCS4/IFNW1/PIAS4/STAT5B/IFNA16/IL13/IFNA8/PIAS1/CREBBP/CNTF/IL19/OSMR/CCND3/STAT3/IL10/PIK3CB/SOS2/JAK1/SOCS5/IL12RB2/LEP/HRAS/PIK3R3/IRF9/SOS1/PTPN2/CDKN1A/PDGFRB/PIK3R1/EP300/IL27RA/PIAS3/MTOR/STAT2/MYC/IFNGR1/IL17D/IFNAR1/CCND2/FHL1/SOCS6/MCL1/PIK3CA/IL6ST/LEPR/IL20RA/AOX1/IL11RA/LIFR/PIK3CD/IL10RB/STAT1/SOCS1/IFNA21/IL6R/CSF2RB/IL12A/IL11/JAK2/SOCS2/IFNE/IL4R/CISH/SOCS3/GHR/IL23A/IL24/CCND1/IFNGR2/IL20RB/PDGFA/IL7/IL15RA/IL13RA2/IFNAR2/CSF3/STAT4/IL7R/IL15/PIM1	147
KEGG	hsa04924	Renin secretion	65/6848	69/8135	0.01028	0.0212	0.009085	ADRB3/PLCB2/PDE1B/REN/CACNA1D/PPP3CB/ADRB1/PRKACB/NPPA/CLCA1/PPP3R2/GNAS/EDN3/ADCYAP1/CLCA4/PRKACA/CALML4/CREB1/NPR1/GNAI3/CACNA1S/CALM2/ADCYAP1R1/PDE3B/ACE/CALML6/EDN2/PLCB3/CALM3/ADCY5/CACNA1F/GNAI2/CALML3/PRKACG/ITPR2/GUCY1A1/CALML5/PDE3A/GNAQ/ADCY6/ITPR3/PPP3CA/CACNA1C/ORAI1/CALM1/GUCY1B1/ADRB2/PLCB1/PDE1C/ADORA1/ITPR1/CLCA2/GUCY1A2/EDNRA/GNAI1/PTGER4/PRKG2/PLCB4/PDE1A/PPP3R1/AGT/AGTR1/PTGER2/KCNJ2/EDN1	65
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	200/6848	223/8135	0.01119	0.02292	0.009824	NOX1/PTPN11/NDUFA11/MAPK11/PTK2/CYP1A2/COX8C/SLC25A31/ATP5F1C/NDUFS3/MAP2K7/MAPK12/ARAF/NDUFA10/ATP5PB/UQCRFS1/MAPK1/NDUFC2/COX4I1/AKT2/NDUFV1/SDHC/PRKD3/EPHX3/ATP5PF/KRAS/MAPK14/BAD/COX6A1/UQCRC1/ATP5F1A/UQCR10/SLC26A9/EGFR/PDPK1/ARNT/VDAC3/EGF/MAPK3/NDUFB4/SRC/EPHX4/MAPK9/UQCRH/COX6B1/NDUFS4/NDUFB8/RAF1/NDUFB9/COX7B2/NDUFB10/AKT1/IKBKG/IKBKB/NDUFA13/VDAC2/NDUFA8/COX5B/SLC25A6/COX8A/NDUFA9/NDUFB5/COX5A/RAC1/MAP2K4/PLD2/SDHD/LPO/GSTA1/CYP2F1/PIK3R2/ATP5F1D/PRKD2/ATP5PD/UQCR11/SLC26A1/COX2/SDHB/ACP1/NDUFS7/NDUFB2/PTPRJ/ND4/EPHX1/AKR1C4/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/COX4I2/GRB2/NDUFB3/SOD1/COX7A2L/AKT3/UQCRQ/NDUFA1/NDUFA5/NCF1/COX7C/BRAF/UQCRB/MAP2K2/SDHA/PTEN/NDUFB7/AKR1A1/HIF1A/COX6C/NDUFB11/SLC25A5/NDUFA12/GSTA3/CHUK/NDUFA3/KEAP1/GSTM4/NDUFC1/MAPK8/CYP2E1/ATP5F1E/NDUFS2/SLC26A6/MGST3/NDUFB1/PRKD1/RELA/ATP5MC3/NDUFV2/ATP5MC2/CBR1/NDUFS5/NDUFA7/SLC25A4/PIK3CB/SOS2/CYC1/GSTO2/COX7A2/CYP1A1/GSTM1/NDUFS1/HRAS/PIK3R3/CYBA/SOS1/NDUFS8/NRAS/PIK3R1/ATP5MC1/FOXO3/GSTA4/MGST1/MAP2K1/ND5/COX7B/GSTO1/VDAC1/PPIF/NQO1/MET/NDUFV3/ABL1/PIK3CA/SLC26A2/NCF2/MAP3K14/PIK3CD/PRKCD/VEGFA/HGF/EPHX2/MAPK10/NFE2L2/CAT/MAPK13/ABL2/PLD1/COX7A1/NDUFA4/AS3MT/AKR1C3/NDUFA4L2/AKR1C1/MGST2/AKR1C2/GSTM3/GSTM5/PTPN1/HMOX1/AHR/NOX4/NFKB1/CYP1B1/JUN/MAP3K5/FOS/SOD2/NFKBIA	200
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	26/6848	26/8135	0.01127	0.02296	0.009842	PIGG/GPAA1/GPLD1/PIGO/PIGL/PIGS/PIGQ/PIGY/PIGT/PIGH/MPPE1/PIGN/PIGF/PIGU/PIGB/PGAP1/PIGC/DPM2/PIGM/PIGK/PIGZ/PIGX/PIGP/PIGA/PIGV/PIGW	26
KEGG	hsa04972	Pancreatic secretion	94/6848	102/8135	0.01319	0.02669	0.01144	ATP2B2/PLCB2/CFTR/ATP1A4/RYR2/PRKCG/CPB2/PRKCB/SLC4A2/SCTR/PNLIP/ATP2B3/PLA2G12B/CCK/CLCA1/FXYD2/ATP2A1/GNAS/RAP1A/PLA2G2D/ATP1A2/CLCA4/ATP1B4/PNLIPRP1/ATP1B2/SLC26A3/PLA2G10/PRSS3/KCNQ1/RAB11A/ATP2A3/CEL/CPA1/PRSS1/CELA3A/RAB8A/ATP1A1/PLA2G2F/CHRM3/CELA2A/TPCN2/CCKAR/PLA2G3/RAC1/ADCY2/ATP2A2/RHOA/ADCY1/ATP1B3/SCT/PLCB3/CA2/PNLIPRP2/CTRL/ADCY9/CTRB2/ATP1A3/SLC9A1/PLA2G1B/SLC12A2/ADCY5/CELA3B/PRKCA/ADCY3/RAB3D/ITPR2/GNAQ/ADCY6/CPA2/RAP1B/PRSS2/CELA2B/PLA2G12A/ADCY7/SLC4A4/ITPR3/TRPC1/ATP2B4/PLCB1/PLA2G5/BST1/ADCY8/ITPR1/CLCA2/CD38/RAB27B/AMY2B/ADCY4/PLCB4/PLA2G2A/CPA3/ATP1B1/ATP2B1/CPB1	94
KEGG	hsa01250	Biosynthesis of nucleotide sugars	36/6848	37/8135	0.01344	0.02705	0.01159	HKDC1/MIOX/HK3/GALT/GPI/TSTA3/FPGT/MPI/NAGK/FCSK/PGM1/HK1/PMM2/NANP/PMM1/UAP1L1/CMAS/GALK2/GFPT1/GNE/GMPPA/GALK1/UGP2/UGDH/GALE/PGM3/TGDS/NANS/GNPNAT1/PGM2/HK2/UAP1/GMPPB/GMDS/UXS1/GFPT2	36
KEGG	hsa00620	Pyruvate metabolism	45/6848	47/8135	0.01446	0.02891	0.01239	PCK1/ADH6/ACOT12/ADH7/LDHAL6B/GLO1/PKLR/ACACA/ADH1A/ADH4/DLD/ACAT1/PDHA1/ME2/MDH1/GRHPR/PKM/LDHD/LDHB/PDHA2/LDHA/AKR1A1/DLAT/ACSS2/MDH2/ME3/PDHB/HAGH/ADH5/LDHC/FH/ACYP2/ACACB/ALDH9A1/PCK2/ACAT2/ALDH2/ME1/ALDH7A1/ALDH3A2/ALDH1B1/PC/ADH1C/ACYP1/ADH1B	45
KEGG	hsa00350	Tyrosine metabolism	35/6848	36/8135	0.0156	0.03066	0.01314	COMT/HGD/ADH6/DCT/TYR/ALDH3B2/ADH7/TYRP1/ALDH3A1/PNMT/DBH/TAT/ADH1A/ADH4/GOT2/HPD/GOT1L1/TH/LRTOMT/TPO/GSTZ1/MIF/AOC2/ALDH3B1/ADH5/FAHD1/FAH/GOT1/MAOA/AOX1/AOC3/MAOB/ADH1C/ADH1B/IL4I1	35
KEGG	hsa00512	Mucin type O-glycan biosynthesis	35/6848	36/8135	0.0156	0.03066	0.01314	B3GNT6/GCNT4/GALNTL5/GALNT8/ST6GALNAC1/ST6GALNAC2/B3GNT3/GALNT9/GALNTL6/ST6GALNAC3/GALNT5/GCNT3/GALNT14/ST3GAL2/GALNT12/GALNT17/GALNT11/GALNT10/GALNT6/GALNT16/GALNT7/C1GALT1C1/GALNT2/C1GALT1C1L/ST6GALNAC4/GCNT1/GALNT4/GALNT18/GALNT3/B4GALT5/GALNT13/ST3GAL1/GALNT1/C1GALT1/GALNT15	35
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	35/6848	36/8135	0.0156	0.03066	0.01314	NT5M/ENPP3/NT5C1B/SIRT6/NT5DC4/NADK/SIRT2/ASPDH/NMNAT3/NADSYN1/NT5C1A/SIRT3/NMRK2/NT5C/NT5E/SIRT5/NT5C2/NMNAT1/NMNAT2/SIRT7/NADK2/NAPRT/ENPP1/NUDT12/NMRK1/BST1/AOX1/SIRT1/CD38/NNMT/NNT/SIRT4/PNP/NAMPT/QPRT	35
KEGG	hsa04930	Type II diabetes mellitus	44/6848	46/8135	0.01654	0.0323	0.01384	HKDC1/CACNA1E/CACNA1B/CACNA1D/PDX1/SLC2A4/KCNJ11/INS/MAPK1/PKLR/IRS4/HK3/MAPK3/MAPK9/ADIPOQ/IKBKB/SLC2A2/CACNA1G/PIK3R2/PRKCE/PKM/SOCS4/ABCC8/MAPK8/PRKCZ/HK1/PIK3CB/CACNA1A/PIK3R3/CACNA1C/PIK3R1/MTOR/TNF/PIK3CA/PIK3CD/PRKCD/SOCS1/HK2/INSR/MAPK10/SOCS2/SOCS3/IRS1/IRS2	44
KEGG	hsa02010	ABC transporters	43/6848	45/8135	0.0189	0.03655	0.01567	ABCG4/CFTR/ABCB9/ABCB11/ABCA13/ABCG1/ABCA12/DEFB1/ABCA4/ABCD2/ABCD3/ABCA2/ABCB1/ABCD1/ABCB8/ABCC12/ABCC11/ABCG8/ABCC6/ABCD4/ABCC8/ABCB10/ABCC10/ABCA3/ABCB4/ABCA7/ABCC4/ABCG2/ABCC9/ABCC2/ABCC3/ABCB7/ABCB5/ABCC1/ABCB6/ABCC5/TAP1/ABCA5/ABCA1/TAP2/ABCA9/ABCA8/ABCA6	43
KEGG	hsa03060	Protein export	23/6848	23/8135	0.01893	0.03655	0.01567	SEC11A/SRP14/SRP9/SEC61A2/SEC62/IMMP2L/SPCS1/SRPRA/SRP68/SEC61A1/SRP72/SEC61B/OXA1L/SPCS2/SRP19/SEC63/SRP54/SEC11C/IMMP1L/SPCS3/HSPA5/SRPRB/SEC61G	23
KEGG	hsa00340	Histidine metabolism	22/6848	22/8135	0.0225	0.04295	0.01841	ALDH3B2/CARNS1/FTCD/AOC1/ALDH3A1/UROC1/CNDP1/HAL/HDC/AMDHD1/ALDH3B1/CNDP2/ALDH9A1/CARNMT1/MAOA/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/HNMT/MAOB/ASPA	22
KEGG	hsa00900	Terpenoid backbone biosynthesis	22/6848	22/8135	0.0225	0.04295	0.01841	HMGCS2/FNTA/FNTB/MVK/ICMT/ACAT1/RCE1/GGPS1/ZMPSTE24/FDPS/PDSS2/PMVK/NUS1/MVD/DHDDS/IDI2/ACAT2/IDI1/HMGCR/HMGCS1/PDSS1/PCYOX1	22
KEGG	hsa00051	Fructose and mannose metabolism	32/6848	33/8135	0.0243	0.04561	0.01955	TKFC/PFKFB1/HKDC1/ALDOB/KHK/PFKFB4/HK3/FBP2/PFKFB2/PFKL/TSTA3/FPGT/MPI/ALDOA/FCSK/HK1/PMM2/PMM1/SORD/TIGAR/AKR1B10/PFKM/GMPPA/ENOSF1/ALDOC/HK2/PFKP/GMPPB/AKR1B1/GMDS/FBP1/PFKFB3	32
KEGG	hsa03410	Base excision repair	32/6848	33/8135	0.0243	0.04561	0.01955	HMGB1/OGG1/PARP3/LIG3/POLL/APEX1/POLE/MUTYH/POLD4/LIG1/NEIL1/POLD1/POLD2/PARP1/MPG/XRCC1/APEX2/POLE4/SMUG1/TDG/POLE3/MBD4/NEIL2/PARP2/POLB/NTHL1/UNG/NEIL3/POLD3/PCNA/POLE2/FEN1	32
KEGG	hsa04130	SNARE interactions in vesicular transport	32/6848	33/8135	0.0243	0.04561	0.01955	VTI1A/VAMP2/STX16/STX5/SNAP29/USE1/STX19/GOSR1/VAMP5/VAMP7/VAMP3/VTI1B/SNAP23/BET1L/STX1B/STX6/STX8/VAMP1/STX17/GOSR2/BNIP1/STX7/STX2/STX3/VAMP4/STX1A/YKT6/VAMP8/STX4/BET1/STX11/SEC22B	32
KEGG	hsa00071	Fatty acid degradation	41/6848	43/8135	0.02464	0.04598	0.01971	ADH6/ACSBG1/ADH7/ACSL6/ECHS1/ADH1A/ADH4/ACAA1/ACAT1/ACADS/ACSBG2/CPT1A/HADHA/ECI2/ACAA2/GCDH/HADHB/ACADL/ACADVL/ECI1/ACADM/CPT1C/ADH5/CYP2U1/EHHADH/HADH/ACADSB/ALDH9A1/CPT1B/ACSL1/ACAT2/ACOX1/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/ACSL5/CPT2/ACSL3/ADH1C/ADH1B	41
KEGG	hsa04260	Cardiac muscle contraction	80/6848	87/8135	0.02522	0.04681	0.02006	CACNG4/CACNG8/TRDN/MYH6/CACNG2/ATP1A4/RYR2/CACNA1D/TNNT2/CACNG6/COX8C/FXYD2/CACNG3/ATP2A1/ATP1A2/ATP1B4/TNNI3/SLC8A3/ATP1B2/UQCRFS1/CACNA2D1/COX4I1/MYL4/ATP2A3/COX6A1/UQCRC1/UQCR10/HRC/TNNC1/CACNB1/ATP1A1/MYL2/UQCRH/COX6B1/CACNA1S/CACNG7/CACNG5/COX7B2/SLC8A2/COX5B/COX8A/COX5A/ATP2A2/ATP1B3/UQCR11/COX2/ATP1A3/SLC9A1/COX6B2/COX4I2/COX7A2L/CACNA2D4/CASQ2/UQCRQ/TPM4/CACNA1F/MYL3/COX7C/UQCRB/COX6C/CACNA2D2/ASPH/CACNB2/MYH7/TPM2/SLC8A1/SLC9A6/CYC1/COX7A2/TPM3/SLC9A7/CACNB3/CACNA1C/COX7B/TPM1/CACNB4/COX7A1/CACNA2D3/ACTC1/ATP1B1	80
KEGG	hsa05230	Central carbon metabolism in cancer	65/6848	70/8135	0.02538	0.04682	0.02007	NTRK3/GLS2/HKDC1/PGAM2/ERBB2/TP53/LDHAL6B/RET/PDGFRA/MAPK1/SIRT6/AKT2/KRAS/EGFR/HK3/MAPK3/RAF1/FGFR3/AKT1/SLC2A2/NTRK1/PDHA1/PIK3R2/PKM/LDHB/G6PD/SIRT3/PFKL/AKT3/FLT3/PDHA2/MAP2K2/PTEN/LDHA/HIF1A/SLC1A5/PGAM1/GLS/IDH2/HK1/PDHB/PIK3CB/TIGAR/FGFR2/LDHC/HRAS/PIK3R3/NRAS/PFKM/PDGFRB/PIK3R1/PDK1/SCO2/MAP2K1/MTOR/MET/MYC/IDH1/PIK3CA/SLC16A3/PIK3CD/HK2/PFKP/SLC7A5/SLC2A1	65
KEGG	hsa04974	Protein digestion and absorption	94/6848	103/8135	0.02617	0.04802	0.02058	COL4A6/SLC15A1/COL25A1/ACE2/KCNJ13/SLC3A1/SLC6A19/ATP1A4/CPB2/FXYD2/COL20A1/COL2A1/ATP1A2/COL26A1/ATP1B4/SLC8A3/ATP1B2/COL28A1/PRSS3/SLC9A3/KCNQ1/COL19A1/COL4A5/CPA1/PRSS1/CELA3A/ATP1A1/SLC16A10/MEP1A/MEP1B/CELA2A/COL9A1/SLC8A2/COL6A1/COL17A1/COL6A2/ATP1B3/COL14A1/CTRL/CTRB2/ATP1A3/COL4A3/KCNK5/COL12A1/CELA3B/COL9A2/SLC1A5/COL6A3/CPA2/SLC36A1/SLC8A1/COL9A3/COL18A1/PRSS2/CELA2B/KCNE3/SLC7A9/COL1A1/COL1A2/PRCP/COL8A1/COL22A1/SLC7A8/SLC3A2/SLC7A7/SLC36A4/COL10A1/SLC1A1/COL4A2/COL27A1/XPNPEP2/SLC38A2/COL5A1/DPP4/COL5A2/ELN/COL7A1/COL8A2/COL3A1/COL4A1/KCNN4/COL16A1/COL13A1/COL5A3/CPA3/COL21A1/COL24A1/MME/COL11A1/ATP1B1/COL15A1/COL4A4/COL6A6/CPB1	94
KEGG	hsa00770	Pantothenate and CoA biosynthesis	21/6848	21/8135	0.02674	0.04881	0.02092	UPB1/ENPP3/VNN2/COASY/PPCS/PANK2/PPCDC/GADL1/PANK3/BCAT2/DPYD/CSAD/PANK1/AASDHPPT/ENPP1/DPYS/BCAT1/ALDH2/ALDH3A2/ALDH1B1/VNN1	21
KEGG	hsa04730	Long-term depression	56/6848	60/8135	0.02919	0.05298	0.02271	NOS1/GNAO1/PLCB2/GNA13/GRIA2/GRM1/PPP2R1A/PRKCG/PRKCB/CRHR1/GNAS/ARAF/MAPK1/PLA2G4F/CRH/KRAS/GNAI3/MAPK3/PPP1R17/RAF1/GRID2/GNA12/RYR1/PLCB3/PPP2CB/PPP2R1B/GNAI2/BRAF/GNAZ/MAP2K2/PRKCA/ITPR2/GUCY1A1/GNAQ/CACNA1A/ITPR3/PLA2G4C/HRAS/PPP2CA/NRAS/MAP2K1/PRKG1/GUCY1B1/PLCB1/GRIA1/IGF1R/GNA11/ITPR1/GRIA3/GUCY1A2/GNAI1/PRKG2/PLCB4/IGF1/LYN/PLA2G4A	56
KEGG	hsa00270	Cysteine and methionine metabolism	48/6848	51/8135	0.02935	0.05299	0.02271	LDHAL6B/MAT1A/TAT/SDS/AHCYL2/GOT2/KYAT1/GOT1L1/MDH1/AGXT2/DNMT3A/LDHB/GSS/LDHA/AHCYL1/AHCY/DNMT3B/BHMT/ADI1/MDH2/MAT2A/SDSL/BCAT2/KYAT3/APIP/LDHC/MRI1/DNMT1/MPST/MTR/CBS/MTAP/ENOPH1/AMD1/GCLM/GOT1/CTH/BHMT2/GCLC/TST/BCAT1/PHGDH/SRM/LACC1/PSAT1/CDO1/SMS/IL4I1	48
KEGG	hsa04970	Salivary secretion	85/6848	93/8135	0.03111	0.05586	0.02394	ATP2B2/ADRB3/NOS1/ADRA1A/LYZ/PLCB2/STATH/RYR3/MUC5B/ATP1A4/PRKCG/ADRB1/PRKCB/VAMP2/SLC4A2/ATP2B3/PRKACB/ADRA1B/HTN3/FXYD2/GNAS/CST3/ATP1A2/ATP1B4/PRKACA/MUC7/ATP1B2/CAMP/DMBT1/CALML4/CST2/TRPV6/ADRA1D/CST5/PRB1/AQP5/LYZL1/ATP1A1/CALM2/CHRM3/BEST2/ADCY2/ADCY1/ATP1B3/LPO/CALML6/PLCB3/HTN1/ADCY9/ATP1A3/CALM3/SLC9A1/SLC12A2/ADCY5/PRKCA/CALML3/CST4/PRKACG/ADCY3/CST1/ITPR2/GUCY1A1/CALML5/GNAQ/ADCY6/ADCY7/ITPR3/CALM1/PRKG1/GUCY1B1/ATP2B4/ADRB2/PLCB1/BST1/ADCY8/ITPR1/CD38/GUCY1A2/KCNN4/PRKG2/AMY2B/ADCY4/PLCB4/ATP1B1/ATP2B1	85
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	20/6848	20/8135	0.03178	0.05677	0.02433	B3GAT3/CHST12/CHPF/CHST14/XYLT2/CHST13/CHPF2/B3GALT6/B4GALT7/XYLT1/CHST7/CSGALNACT2/CHST3/CHSY1/UST/DSE/CHSY3/CHST11/CHST15/CSGALNACT1	20
KEGG	hsa00410	beta-Alanine metabolism	30/6848	31/8135	0.03255	0.05767	0.02472	UPB1/ALDH3B2/GAD2/GAD1/CARNS1/ALDH3A1/ECHS1/CNDP1/ACADS/HADHA/MLYCD/GADL1/AOC2/ALDH3B1/CNDP2/DPYD/EHHADH/HIBCH/CSAD/ALDH6A1/ALDH9A1/SMOX/DPYS/AOC3/ACOX1/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/ABAT	30
KEGG	hsa04330	Notch signaling pathway	55/6848	59/8135	0.03263	0.05767	0.02472	NCSTN/DTX1/NCOR2/PTCRA/SNW1/DTX3/NOTCH3/TLE6/DLL1/RFNG/HEYL/DLL3/MFNG/PSEN1/DVL3/NUMB/CTBP1/DVL1/RBPJL/DTX2/NUMBL/MAML3/APH1A/JAG2/DVL2/CTBP2/KAT2A/CREBBP/APH1B/HES5/PSEN2/HDAC1/NOTCH2/NOTCH4/NOTCH1/ATXN1L/HEY2/TLE4/TLE3/EP300/HDAC2/TLE2/ADAM17/DTX3L/PSENEN/LFNG/TLE1/CIR1/MAML2/ATXN1/KAT2B/DTX4/HEY1/JAG1/HES1	55
KEGG	hsa03320	PPAR signaling pathway	69/6848	75/8135	0.03623	0.06368	0.0273	SLC27A2/FABP7/PCK1/APOA5/APOA2/PLIN5/HMGCS2/ACSBG1/FABP2/UBC/UCP1/FABP1/SORBS1/APOC3/ILK/ACSL6/RXRB/PLIN4/PDPK1/SLC27A5/APOA1/PLIN1/ACAA1/RXRG/ADIPOQ/GK2/FABP6/SCD5/ACSBG2/AQP7/CPT1A/RXRA/ACADL/SCP2/ACADM/SCD/ME3/LPL/DBI/CPT1C/SLC27A4/PPARA/EHHADH/OLR1/PLTP/CPT1B/ACOX2/PLIN2/GK/PPARD/PCK2/ACSL1/NR1H3/SLC27A1/CYP27A1/ACOX1/HMGCS1/ME1/CYP8B1/ACSL5/ANGPTL4/CPT2/PPARG/ACSL3/FADS2/CYP7A1/FABP3/FABP4/CD36	69
KEGG	hsa00030	Pentose phosphate pathway	29/6848	30/8135	0.03762	0.06571	0.02817	ALDOB/TKTL1/H6PD/TKTL2/GLYCTK/PRPS1L1/FBP2/PGLS/G6PD/PFKL/DERA/GPI/ALDOA/RPE/RBKS/IDNK/PGM1/TALDO1/PRPS2/PFKM/PGD/TKT/RPIA/ALDOC/PRPS1/PGM2/PFKP/RGN/FBP1	29
KEGG	hsa00531	Glycosaminoglycan degradation	19/6848	19/8135	0.03777	0.06571	0.02817	HGSNAT/HYAL4/SPAM1/HPSE2/HYAL2/IDUA/IDS/GNS/GLB1/SGSH/HYAL3/HEXB/GUSB/HEXA/NAGLU/GALNS/ARSB/HYAL1/HPSE	19
KEGG	hsa04146	Peroxisome	75/6848	82/8135	0.04064	0.07033	0.03014	AGXT/PEX14/HMGCLL1/SLC27A2/BAAT/PEX5L/PEX16/NOS2/CRAT/PEX19/DAO/ABCD2/ACOT8/ACSL6/PEX7/ABCD3/MVK/PAOX/HAO2/ABCD1/PEX10/ACAA1/PEX3/SLC25A17/MPV17L/PIPOX/PEX5/GNPAT/ECI2/SOD1/PEX1/MPV17/XDH/FAR1/MLYCD/SCP2/HMGCL/ABCD4/PRDX1/DECR2/HACL1/AGPS/PXMP2/PEX2/IDH2/PEX11B/PMVK/ECH1/PEX26/HSD17B4/PEX11A/PRDX5/EHHADH/FAR2/GSTK1/PXMP4/CROT/PECR/PEX12/DDO/ACOX2/NUDT12/IDH1/ACSL1/ACOX1/PEX13/MPV17L2/PHYH/EPHX2/ACSL5/CAT/PEX6/NUDT7/ACSL3/SOD2	75
KEGG	hsa04392	Hippo signaling pathway - multiple species	28/6848	29/8135	0.04345	0.07442	0.0319	RASSF6/DCHS2/FRMD1/YAP1/LATS1/TEAD2/CSNK1E/NF2/TEAD3/WWC1/LIMD1/TEAD4/MOB1A/PAK1/WTIP/DCHS1/MOB1B/RASSF1/RASSF4/RASSF2/WWTR1/STK3/LATS2/AJUBA/FRMD6/TEAD1/SAV1/FAT4	28
KEGG	hsa04744	Phototransduction	28/6848	29/8135	0.04345	0.07442	0.0319	GUCA1A/CNGB1/RGS9/GNGT1/GNAT1/RHO/SAG/CNGA1/GUCA1C/CALML4/PDE6G/GRK1/SLC24A1/RCVRN/PDE6A/CALM2/PDE6B/GUCA1B/CALML6/GUCY2F/CALM3/GNAT2/GRK7/CALML3/GNB1/CALML5/GUCY2D/CALM1	28
KEGG	hsa04340	Hedgehog signaling pathway	52/6848	56/8135	0.04535	0.07729	0.03313	IHH/HHIP/ARRB2/GLI1/PRKACB/FBXW11/SUFU/BCL2/CUL1/PRKACA/SHH/LRP2/IQCE/CSNK1D/BTRC/CUL3/GRK2/CSNK1A1/MGRN1/PTCH2/CSNK1E/EVC/HHATL/GRK3/PTCH1/SMURF1/PRKACG/KIF7/CSNK1G1/HHAT/CSNK1G2/EVC2/SPOPL/CSNK1G3/GPR161/SMO/GSK3B/BOC/ARRB1/MEGF8/SPOP/GAS1/CCND2/DISP1/SCUBE2/KIF3A/GLI2/CDON/CCND1/EFCAB7/SMURF2/GLI3	52
KEGG	hsa05340	Primary immunodeficiency	36/6848	38/8135	0.04706	0.07979	0.0342	PTPRC/BTK/CD79A/JAK3/IGLL1/IL2RG/CIITA/CD8B/CD3E/ZAP70/RAG1/RAG2/TNFRSF13B/AICDA/CD8A/CD40LG/IKBKG/CD19/CD4/LCK/CD3D/RFXANK/AIRE/TNFRSF13C/ICOS/ORAI1/UNG/DCLRE1C/RFX5/BLNK/ADA/RFXAP/CD40/TAP1/TAP2/IL7R	36
KEGG	hsa04064	NF-kappa B signaling pathway	94/6848	104/8135	0.04744	0.08002	0.0343	SYK/CARD14/EDA/BTK/TNFSF11/PRKCB/TAB3/CARD11/UBE2I/ZAP70/BCL2/TIRAP/BCL2L1/EDARADD/CSNK2B/LTBR/TNFRSF1A/PLCG2/CCL21/CSNK2A1/TRAF6/CD40LG/TAB1/IKBKG/IKBKB/LTB/PLCG1/TRADD/LCK/PRKCQ/IL1R1/EDA2R/CSNK2A2/IRAK1/IRAK4/MAP3K7/CCL19/TNFRSF13C/PIAS4/CHUK/EDAR/PARP1/TNFRSF11A/ATM/PIDD1/XIAP/RELA/LAT/MYD88/RIPK1/LBP/TNFSF14/TRAF2/ERC1/BCL10/MALT1/TRAF5/TRIM25/LY96/BIRC2/TAB2/TICAM2/NFKB2/TNF/PLAU/BLNK/CARD10/MAP3K14/TICAM1/TRAF3/CXCL12/CD40/GADD45G/TLR4/DDX58/CYLD/CFLAR/TNFSF13B/RELB/CCL13/GADD45A/CD14/CCL4/VCAM1/NFKB1/TRAF1/LYN/CXCL1/GADD45B/CXCL3/CXCL8/CXCL2/NFKBIA/ICAM1	94
KEGG	hsa00910	Nitrogen metabolism	17/6848	17/8135	0.05335	0.08918	0.03822	CA14/CA6/CA7/CA9/CA4/CA3/CA5B/GLUD2/CA2/CA1/GLUD1/CA13/CA5A/GLUL/CA8/CPS1/CA12	17
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	35/6848	37/8135	0.0534	0.08918	0.03822	GLS2/AGXT/RIMKLA/GAD2/GAD1/ALDH4A1/NAT8L/GOT2/GOT1L1/ASRGL1/GLUD2/AGXT2/ADSL/FOLH1/ALDH5A1/GPT/NIT2/ASL/GLUD1/GLS/CAD/RIMKLB/GLUL/GFPT1/DDO/GPT2/GOT1/CPS1/PPAT/ASS1/ABAT/ASNS/ASPA/IL4I1/GFPT2	35
KEGG	hsa05162	Measles	124/6848	139/8135	0.05906	0.09814	0.04207	TP73/CD209/CLEC4M/JAK3/FASLG/IL2RG/IL2RA/IRF3/TLR7/CD28/CD3E/TP53/BCL2/IFNA6/CD46/AKT2/HSPA6/BCL2L1/IFNB1/FCGR2B/CSNK2B/BAD/IL2/SLAMF1/CD3G/IFNA2/CSNK2A1/TRAF6/MAPK9/IFNA5/IL12B/RACK1/AKT1/RCHY1/IKBKG/IKBKB/IL2RB/TRADD/CD3D/TYK2/PIK3R2/IFNA1/CSNK2A2/CDK2/IRAK1/IRAK4/CASP8/ADAR/MAP3K7/IFNA14/AKT3/EIF2AK1/EIF3H/STAT5B/CDK4/IFNA16/CHUK/CASP9/IFNA8/MAPK8/TBK1/MAVS/RELA/MYD88/CCND3/STAT3/PIK3CB/NFKBIB/CASP3/JAK1/APAF1/IKBKE/GSK3B/PIK3R3/IRF9/EIF2S1/HSPA1A/EIF2AK2/PIK3R1/BBC3/BAX/FADD/TAB2/STAT2/BAK1/IFNAR1/CCND2/MSN/PIK3CA/OAS2/CCNE1/EIF2AK3/EIF2AK4/PIK3CD/CYCS/HSPA1L/FAS/TLR2/TRAF3/STAT1/IFNA21/MAPK10/IL12A/IRF7/CDK6/CBLB/OAS3/TLR4/DDX58/CCNE2/CCND1/OAS1/RAB9A/MX1/HSPA2/CDKN1B/MX2/IFIH1/NFKB1/IFNAR2/JUN/BID/FOS/NFKBIA	124
KEGG	hsa04610	Complement and coagulation cascades	77/6848	85/8135	0.06315	0.1043	0.04471	CR1/F5/KNG1/MASP2/FGA/F2/C8A/CPB2/VWF/F13B/CR2/C1QC/PROC/FGB/F7/F11/PLG/C4BPB/VSIG4/CD46/SERPINC1/CFHR3/C1S/C1QA/VTN/ITGAX/FGG/CFHR5/SERPIND1/F9/F12/C8B/F13A1/C4BPA/MBL2/CD59/KLKB1/C5AR1/ITGAM/C1QB/CR1L/SERPINF2/C6/C7/MASP1/C1R/C8G/C9/CFHR2/C2/SERPING1/F8/CFH/C3AR1/SERPINA5/PROS1/CD55/C5/PLAU/TFPI/SERPINE1/CLU/PROCR/PLAUR/F2RL2/THBD/ITGB2/F3/F10/PLAT/C3/CFD/A2M/CFI/SERPINA1/BDKRB2/BDKRB1	77
KEGG	hsa00430	Taurine and hypotaurine metabolism	16/6848	16/8135	0.0634	0.1043	0.04471	BAAT/GGT6/GAD2/GAD1/GGT7/GGT1/FMO5/GADL1/GGT5/CSAD/ADO/FMO3/CDO1/FMO4/FMO2/FMO1	16
KEGG	hsa05169	Epstein-Barr virus infection	178/6848	202/8135	0.06895	0.1129	0.04839	SYK/BTK/NCOR2/ITGAL/HLA-DQB1/HLA-DOA/JAK3/FCER2/SNW1/MAPK11/HLA-DQA1/POLK/B2M/IRF3/ENTPD3/CR2/CD3E/TP53/PSMD4/BCL2/MAP2K7/MAPK12/IFNA6/VIM/RUNX3/E2F2/AKT2/IFNB1/MAPK14/CD3G/IFNA2/PSMD6/PLCG2/RB1/TRAF6/MAPK9/IFNA5/TAB1/PSMC2/AKT1/IKBKG/IKBKB/CD19/TRADD/PSMC1/USP7/RAC1/MAP2K4/SEM1/CD3D/E2F1/TYK2/PIK3R2/IFNA1/CDK2/IRAK1/IRAK4/CASP8/BCL2L11/PSMD1/MAP3K7/IFNA14/PSMD2/RBPJL/AKT3/PSMD7/PSMC6/CDK4/IFNA16/CHUK/CASP9/IFNA8/HLA-G/SAP30L/MAPK8/PSMD13/TBK1/MAVS/RELA/MYD88/CCND3/HDAC1/PSMD8/RIPK1/MDM2/STAT3/PIK3CB/PSMD3/NFKBIB/CASP3/JAK1/PSMC5/APAF1/CALR/ADRM1/E2F3/PSMC3/TRAF2/IKBKE/PSMC4/PIK3R3/IRF9/PDIA3/PSMD11/PSMD12/EIF2AK2/CDKN1A/PIK3R1/SKP2/HDAC2/TRAF5/CD44/BAX/FADD/PSMD14/TAB2/HLA-DPA1/HLA-F/STAT2/NFKB2/MYC/BAK1/MAP2K6/IFNAR1/TNF/CCND2/PIK3CA/BLNK/OAS2/ENTPD1/CCNE1/SAP30/CIR1/MAP3K14/PIK3CD/CYCS/FAS/TLR2/TRAF3/HLA-E/CCNA2/STAT1/CD247/IFNA21/NEDD4/CD40/GADD45G/SIN3A/CCNA1/MAPK10/IRF7/HLA-DRA/CDK6/MAPK13/ISG15/TAP1/OAS3/MAP2K3/DDX58/CCNE2/CCND1/OAS1/DDB2/RELB/CD58/TAP2/CDKN1B/GADD45A/NFKB1/IFNAR2/JUN/LYN/BID/NFKBIE/GADD45B/HES1/NFKBIA/ICAM1	178
KEGG	hsa05133	Pertussis	69/6848	76/8135	0.06994	0.1139	0.04884	NLRP3/CFL1/MAPK11/IRF3/NOS2/C1QC/C4BPB/MAPK12/MAPK1/TIRAP/ITGB1/CALML4/C1S/MAPK14/C1QA/GNAI3/MAPK3/TRAF6/MAPK9/CALM2/IL12B/C4BPA/RHOA/CALML6/IRAK1/CALM3/IRAK4/ITGA5/ITGAM/SFTPA2/GNAI2/C1QB/CALML3/IRF8/C1R/CALML5/MAPK8/RELA/MYD88/IL10/CASP3/C2/SERPING1/NOD1/CALM1/LY96/TICAM2/C5/TNF/CFL2/PYCARD/TICAM1/CASP1/MAPK10/IL12A/MAPK13/GNAI1/CASP7/TLR4/IL23A/ITGB2/CD14/C3/NFKB1/JUN/FOS/CXCL8/IRF1/CXCL6	69
KEGG	hsa04978	Mineral absorption	55/6848	60/8135	0.07056	0.1144	0.04903	ATP2B2/SLC6A19/ATP1A4/TF/TRPM6/SLC34A1/ATP2B3/FXYD2/SLC5A1/ATP1A2/CLCN2/ATP1B4/SLC8A3/SLC46A1/ATP1B2/SLC26A3/SLC9A3/FTL/TRPV6/SLC26A9/ATP1A1/SLC34A2/SLC8A2/S100G/SLC34A3/ATP1B3/ATP1A3/ATP7A/CYBRD1/HMOX2/ATOX1/SLC26A6/TRPM7/SLC8A1/SLC39A4/ATP2B4/FTH1/ATP7B/MT1HL1/SLC31A1/VDR/SLC30A1/STEAP1/HEPH/SLC11A2/HMOX1/STEAP2/MT1G/MT2A/MT1E/ATP1B1/MT1F/ATP2B1/MT1M/SLC40A1	55
KEGG	hsa04975	Fat digestion and absorption	40/6848	43/8135	0.07418	0.1197	0.0513	NPC1L1/MOGAT2/PNLIP/PLA2G12B/FABP2/APOB/PLA2G2D/APOA4/PNLIPRP1/FABP1/PLA2G10/AGPAT1/LIPF/CEL/APOA1/DGAT1/PLA2G2F/ACAT1/GOT2/PLA2G3/MTTP/MOGAT3/SCARB1/ABCG8/PNLIPRP2/AGPAT2/PLA2G1B/CLPS/PLPP2/PLA2G12A/SLC27A4/DGAT2/PLPP3/PLA2G5/ACAT2/SLC27A1/PLPP1/ABCA1/PLA2G2A/CD36	40
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	15/6848	15/8135	0.07534	0.121	0.05185	ST8SIA5/B4GALNT1/ST6GALNAC3/GLB1/HEXB/ST6GALNAC5/ST3GAL2/HEXA/ST6GALNAC6/B3GALT4/ST6GALNAC4/SLC33A1/ST3GAL1/ST8SIA1/ST3GAL5	15
KEGG	hsa00330	Arginine and proline metabolism	47/6848	51/8135	0.07687	0.1221	0.05233	NOS1/PRODH/CARNS1/NOS2/AOC1/GATM/CKM/DAO/NOS3/ALDH4A1/CNDP1/ARG1/GOT2/AZIN2/GOT1L1/OAT/CKMT2/GAMT/PYCR2/AGMAT/ALDH18A1/CNDP2/P4HA1/ALDH9A1/PYCR3/SMOX/PYCR1/AMD1/GOT1/ODC1/P4HA2/ARG2/MAOA/SAT2/ALDH2/SRM/LAP3/ALDH7A1/ALDH3A2/L3HYPDH/ALDH1B1/SAT1/P4HA3/CKB/HOGA1/MAOB/SMS	47
KEGG	hsa00010	Glycolysis / Gluconeogenesis	61/6848	67/8135	0.07739	0.1221	0.05233	HKDC1/ALDOB/PCK1/ADH6/PGAM2/ALDH3B2/ADH7/LDHAL6B/PKLR/ALDH3A1/HK3/ADH1A/GAPDH/ADH4/G6PC2/DLD/G6PC/FBP2/GAPDHS/PDHA1/PGK2/PKM/LDHB/G6PC3/PFKL/ADPGK/ENO3/GPI/PDHA2/LDHA/AKR1A1/DLAT/ACSS2/ALDOA/PGAM1/PGM1/HK1/PDHB/ALDH3B1/ADH5/MINPP1/LDHC/PGK1/PFKM/ENO1/ALDH9A1/ALDOC/PCK2/ENO2/ALDH2/ALDH7A1/ALDH3A2/PGM2/ALDH1B1/HK2/BPGM/PFKP/GALM/FBP1/ADH1C/ADH1B	61
KEGG	hsa05221	Acute myeloid leukemia	61/6848	67/8135	0.07739	0.1221	0.05233	MPO/RARA/RPS6KB1/ARAF/MAPK1/AKT2/CEBPE/KRAS/BAD/SPI1/MAPK3/RUNX1/RAF1/ZBTB16/AKT1/IKBKG/IKBKB/CSF1R/RPS6KB2/PIK3R2/GRB2/ITGAM/AKT3/FLT3/PML/BRAF/MAP2K2/STAT5B/CHUK/LEF1/TCF7/RELA/STAT3/PIK3CB/SOS2/HRAS/PIK3R3/SOS1/NRAS/PIK3R1/MAP2K1/PIM2/PER2/MTOR/MYC/PPARD/PIK3CA/TCF7L1/PIK3CD/CCNA2/CCNA1/EIF4EBP1/JUP/CEBPA/TCF7L2/DUSP6/CCND1/RUNX1T1/CD14/NFKB1/PIM1	61
KEGG	hsa03020	RNA polymerase	32/6848	34/8135	0.07749	0.1221	0.05233	POLR2A/POLR2B/POLR2C/POLR2E/POLR3C/POLR2F/POLR2L/POLR3G/POLR3F/CRCP/CD3EAP/POLR2H/POLR2G/POLR1E/ZNRD1/POLR2M/POLR1D/POLR1A/POLR2D/POLR3B/POLR3A/POLR2K/POLR3E/POLR1B/POLR3D/POLR3H/POLR3GL/POLR1C/TWISTNB/POLR2I/POLR3K/POLR2J3	32
KEGG	hsa05145	Toxoplasmosis	100/6848	112/8135	0.0821	0.1286	0.05511	GNAO1/ALOX5/LAMB4/HLA-DQB1/HLA-DOA/MAPK11/HLA-DQA1/LAMA3/CIITA/NOS2/PIK3R5/PIK3CG/BCL2/MAPK12/MAPK1/CCR5/ITGB1/AKT2/LAMC3/HSPA6/BCL2L1/MAPK14/BAD/TNFRSF1A/PDPK1/GNAI3/IL10RA/MAPK3/TRAF6/MAPK9/IFNG/CD40LG/PIK3R6/TAB1/IL12B/AKT1/IKBKG/IKBKB/TYK2/IRGM/IRAK1/TGFB1/IRAK4/CASP8/MAP3K7/AKT3/GNAI2/LAMA4/BIRC7/CHUK/TGFB3/CASP9/MAPK8/XIAP/LAMC1/RELA/MYD88/STAT3/IL10/NFKBIB/CASP3/JAK1/LAMB2/LAMA5/HSPA1A/LY96/BIRC2/PPIF/TAB2/HLA-DPA1/IFNGR1/MAP2K6/TNF/CYCS/HSPA1L/TLR2/LAMB1/IL10RB/STAT1/SOCS1/CD40/LAMA1/LAMC2/MAPK10/IL12A/LDLR/HLA-DRA/MAPK13/GNAI1/JAK2/ITGA6/MAP2K3/TLR4/IFNGR2/HSPA2/TGFB2/LAMA2/NFKB1/LAMB3/NFKBIA	100
KEGG	hsa03015	mRNA surveillance pathway	87/6848	97/8135	0.08239	0.1286	0.05511	PPP2R2D/PPP2R2C/PPP2R1A/SAP18/PAPOLA/WDR33/SYMPK/PPP2R3C/CPSF1/NXF3/PPP1CC/PPP2R5D/CPSF7/CPSF4/PAPOLB/SRRM1/GLE1/RNGTT/PAPOLG/PPP1CB/PPP2R5C/RNMT/PYM1/SMG7/PPP2CB/SMG5/NUDT21/DDX19A/MSI2/GSPT2/CPSF3/MSI1/PPP2R5E/NXT2/PABPC1/EIF4A3/PPP2R1B/SSU72/PPP2R5A/HBS1L/PPP1CA/CPSF6/RNPS1/PPP2R2A/ETF1/CPSF2/CASC3/SMG6/PABPN1/TARDBP/NCBP2/DDX19B/CSTF1/NXF1/NCBP1/PPP2R5B/MAGOH/ACIN1/FIP1L1/PNN/DAZAP1/CLP1/UPF3A/UPF1/PCF11/PABPC4/CSTF2/PPP2R3A/CSTF3/FUS/PPP2CA/UPF2/RBM8A/PABPC1L/CSTF2T/NXT1/PELO/GSPT1/PPP2R3B/PABPC3/PPP2R2B/PABPC4L/PABPC5/UPF3B/SMG1/MAGOHB/ALYREF	87
KEGG	hsa00380	Tryptophan metabolism	39/6848	42/8135	0.08288	0.1287	0.05518	ASMT/CYP1A2/TPH2/IDO2/AOC1/ACMSD/ECHS1/HAAO/DLST/AANAT/DLD/ACAT1/KYAT1/HADHA/GCDH/AFMID/ALDH8A1/AADAT/TDO2/KYAT3/DHTKD1/CYP1A1/EHHADH/HADH/ALDH9A1/ACAT2/MAOA/AOX1/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/CAT/MAOB/KMO/IL4I1/CYP1B1/KYNU/IDO1	39
KEGG	hsa00240	Pyrimidine metabolism	53/6848	58/8135	0.0855	0.1322	0.05666	UPB1/UPP2/NT5M/ENPP3/UCK1/ENTPD3/NT5C1B/ASMTL/NT5DC4/DCTD/UCKL1/CANT1/NT5C1A/CMPK1/ENTPD5/NME7/NT5C/NT5E/NT5C2/TK2/NME3/HDDC2/CAD/ENTPD6/DUT/NME4/NT5C3B/DTYMK/NT5C3A/UMPS/DPYD/DCK/AK9/DHODH/ENTPD4/ENPP1/DPYS/DCTPP1/TK1/CTPS2/CTPS1/ENTPD1/NUDT2/CDA/RRM2B/NME6/TYMS/UPP1/UCK2/NME1/TYMP/RRM2/CMPK2	53
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	23/6848	24/8135	0.08802	0.1355	0.05807	HS6ST3/B3GAT3/NDST3/HS3ST5/EXTL3/EXT2/NDST4/NDST2/XYLT2/NDST1/HS2ST1/EXTL1/HS6ST1/B3GALT6/B4GALT7/XYLT1/HS6ST2/EXTL2/GLCE/HS3ST2/EXT1/HS3ST3B1/HS3ST3A1	23
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	14/6848	14/8135	0.08953	0.1372	0.05879	ST3GAL3/B3GNT7/CHST6/CHST4/B4GALT2/ST3GAL2/B4GALT3/CHST1/B4GALT1/B4GALT4/B3GNT2/FUT8/ST3GAL1/CHST2	14
KEGG	hsa01524	Platinum drug resistance	66/6848	73/8135	0.09054	0.1381	0.05918	FASLG/ERBB2/TP53/BCL2/MAPK1/AKT2/BCL2L1/BAD/CDKN2A/PDPK1/MAPK3/AKT1/GSTA1/PIK3R2/GSTP1/ATP7A/CASP8/AKT3/GSTA3/CASP9/GSTM4/MLH1/MSH3/ATM/XIAP/MGST3/MSH6/MDM2/PIK3CB/BRCA1/CASP3/XPA/APAF1/GSTO2/POLH/GSTM1/PIK3R3/TOP2B/CDKN1A/PIK3R1/GSTA4/MGST1/BBC3/BIRC2/GSTO1/BAX/FADD/ERCC1/ABCC2/BAK1/ATP7B/PIK3CA/PIK3CD/CYCS/FAS/MSH2/SLC31A1/BIRC5/MGST2/GSTM3/GSTM5/TOP2A/REV3L/MAP3K5/PMAIP1/BID	66
KEGG	hsa01212	Fatty acid metabolism	52/6848	57/8135	0.09395	0.142	0.06086	ACSF3/TECR/ACSBG1/ACACA/ACSL6/ECHS1/ACAA1/ACAT1/SCD5/ACADS/ACSBG2/HACD3/CPT1A/HADHA/MECR/CBR4/ELOVL4/PPT1/ACAA2/HSD17B12/FASN/HADHB/ACADL/SCP2/ACADVL/ELOVL5/ACADM/SCD/MCAT/CPT1C/HSD17B4/ELOVL1/EHHADH/FADS1/HADH/ACADSB/CPT1B/HSD17B8/ACSL1/ACAT2/HACD2/ACOX1/OXSM/ELOVL6/HACD4/HACD1/ACSL5/CPT2/ELOVL3/ELOVL2/ACSL3/FADS2	52
KEGG	hsa05134	Legionellosis	52/6848	57/8135	0.09395	0.142	0.06086	CR1/BCL2L13/NLRC4/HSF1/EEF1G/EEF1A1/HSPA6/IL12B/RAB1A/ARF1/EEF1A2/CASP8/ITGAM/HBS1L/CR1L/RAB1B/CASP9/RELA/MYD88/CASP3/APAF1/SAR1B/VCP/TLR5/IL18/HSPA1A/HSPD1/SAR1A/NFKB2/TNF/PYCARD/CYCS/HSPA1L/CLK1/TLR2/CASP1/BNIP3/CLK4/IL12A/CASP7/TLR4/ITGB2/HSPA2/CD14/C3/NFKB1/CXCL1/CXCL3/CXCL8/CXCL2/NFKBIA/SEC22B	52
KEGG	hsa00515	Mannose type O-glycan biosynthesis	22/6848	23/8135	0.101	0.1506	0.06457	ST3GAL3/FUT9/B3GALNT2/MGAT5B/POMT2/LARGE2/POMGNT1/B3GAT2/FKTN/POMT1/B3GAT1/B4GALT2/POMK/B4GALT3/B4GALT1/CHST10/POMGNT2/RXYLT1/FUT4/LARGE1/FKRP/B4GAT1	22
KEGG	hsa03430	Mismatch repair	22/6848	23/8135	0.101	0.1506	0.06457	POLD4/RPA4/LIG1/RFC1/SSBP1/POLD1/POLD2/MLH1/MSH3/RPA1/RPA3/MSH6/RFC3/RFC5/RPA2/POLD3/EXO1/MLH3/PCNA/RFC2/MSH2/RFC4	22
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	22/6848	23/8135	0.101	0.1506	0.06457	GLS2/PCK1/ATP1A4/FXYD2/ATP1A2/ATP1B4/CA4/ATP1B2/SLC25A10/SLC9A3/ATP1A1/SLC38A3/ATP1B3/GLUD2/CA2/MDH1/ATP1A3/GLUD1/GLS/SLC4A4/PCK2/ATP1B1	22
KEGG	hsa00260	Glycine, serine and threonine metabolism	37/6848	40/8135	0.103	0.1529	0.06555	AGXT/SARDH/PGAM2/ALAS2/GATM/DAO/GNMT/GLYCTK/SDS/DLD/PIPOX/AGXT2/GRHPR/GLDC/GAMT/GCAT/SHMT1/BHMT/AOC2/PGAM1/SRR/SDSL/ALAS1/GCSH/SHMT2/CBS/CHDH/CTH/MAOA/AOC3/AMT/PHGDH/ALDH7A1/BPGM/PSPH/MAOB/PSAT1	37
KEGG	hsa03450	Non-homologous end-joining	13/6848	13/8135	0.1064	0.1572	0.06739	XRCC6/LIG4/XRCC5/DNTT/POLL/MRE11/POLM/NHEJ1/RAD50/XRCC4/PRKDC/DCLRE1C/FEN1	13
KEGG	hsa04726	Serotonergic synapse	102/6848	115/8135	0.1104	0.1622	0.0695	GNAO1/GABRB2/KCNJ5/ALOX5/PLCB2/GNGT1/CACNA1B/GNG4/SLC6A4/CACNA1D/PRKCG/PRKCB/HTR4/HTR2C/SLC18A2/ALOX12B/CYP2C9/TPH2/KCNN2/PRKACB/KCNJ3/GNAS/CYP2C8/PRKACA/HTR1A/HTR1D/CYP2C18/ARAF/MAPK1/CYP2C19/PLA2G4F/SLC18A1/HTR3A/RAPGEF3/KRAS/GNG13/GNAI3/MAPK3/HTR3C/GNG3/RAF1/CACNA1S/GNB4/HTR5A/HTR1F/HTR7/HTR3B/HTR1E/GNB2/CYP2J2/GNGT2/PLCB3/KCNJ9/ALOX15/ALOX15B/GNG10/ADCY5/HTR1B/GNG2/GABRB1/CACNA1F/GNAI2/BRAF/ALOX12/GNG8/PRKCA/PRKACG/GNG5/GNB1/ITPR2/GNAQ/HTR6/GABRB3/CASP3/CACNA1A/ITPR3/PLA2G4C/TRPC1/HRAS/CYP2D6/CACNA1C/NRAS/GNG7/GNG12/MAP2K1/GNB5/PLCB1/MAOA/ITPR1/APP/PTGS1/GNAI1/KCNJ6/GNG11/DUSP1/MAOB/PLCB4/HTR2A/HTR2B/CYP4X1/PLA2G4A/KCND2	102
KEGG	hsa00052	Galactose metabolism	29/6848	31/8135	0.1112	0.1622	0.0695	HKDC1/SI/GANC/HK3/G6PC2/G6PC/GALT/LCT/G6PC3/PFKL/GLB1/B4GALT2/PGM1/HK1/GAA/B4GALT1/LALBA/AKR1B10/GLA/PFKM/GALK1/UGP2/GALE/PGM2/HK2/PFKP/GALM/MGAM/AKR1B1	29
KEGG	hsa04710	Circadian rhythm	29/6848	31/8135	0.1112	0.1622	0.0695	SKP1/RORC/PER3/FBXW11/CUL1/RORB/PRKAA1/CSNK1D/CREB1/BTRC/PRKAG1/CSNK1E/PRKAB1/PRKAA2/CLOCK/FBXL3/PRKAG3/PRKAG2/PRKAB2/PER2/CRY2/NR1D1/CRY1/ARNTL/PER1/NPAS2/RORA/BHLHE41/BHLHE40	29
KEGG	hsa01232	Nucleotide metabolism	76/6848	85/8135	0.1157	0.1681	0.07204	ENTPD2/UPP2/NT5M/ENPP3/UCK1/ENTPD3/NT5C1B/ASMTL/AMPD1/AK8/NT5DC4/DCTD/UCKL1/CANT1/NT5C1A/GDA/GMPS/CMPK1/GUK1/AK7/ENTPD5/ADSL/XDH/NME7/NT5C/NT5E/APRT/NT5C2/AK3/TK2/DGUOK/NME3/HDDC2/ENTPD6/AK2/DUT/NME4/NT5C3B/DTYMK/AK1/NUDT16/NT5C3A/IMPDH2/ITPA/AMPD2/DCK/AK9/GMPR2/ENTPD4/NTPCR/IMPDH1/ENPP1/ADK/DCTPP1/TK1/CTPS2/HPRT1/CTPS1/ENTPD1/ADA2/ADA/CDA/RRM2B/NME6/TYMS/UPP1/UCK2/GMPR/AMPD3/NME1/LACC1/PNP/TYMP/RRM2/CMPK2/AK5	76
KEGG	hsa04621	NOD-like receptor signaling pathway	161/6848	184/8135	0.1241	0.1794	0.0769	CASR/TRPM2/NLRP3/PLCB2/CYBB/NLRC4/MAPK11/NLRP12/TAB3/IRF3/YWHAE/ATG5/TP53BP1/MAP1LC3B/BCL2/MAPK12/IFNA6/CAMP/MAPK1/SHARPIN/BCL2L1/IFNB1/DEFA5/ATG16L1/PKN1/MAPK14/GPRC6A/IFNA2/VDAC3/CARD18/MAPK3/DEFA4/TRAF6/MAPK9/IFNA5/TAB1/IKBKG/IKBKB/VDAC2/MFN2/RHOA/NLRX1/TYK2/RBCK1/PLCB3/MFN1/IFNA1/TXN2/HSP90AA1/IRAK4/CASP8/NLRP6/DEFA6/HSP90AB1/PSTPIP1/CARD9/MAP3K7/IFNA14/TRIP6/ANTXR2/DEFB4A/MEFV/GABARAP/GSDMD/PYDC1/ATG12/IFNA16/CHUK/ITPR2/IFNA8/MAPK8/CASP5/TBK1/MAVS/XIAP/RELA/RNF31/TRPM7/MYD88/NLRP7/RIPK1/BRCC3/GABARAPL2/NLRP1/CARD8/NFKBIB/TANK/JAK1/DHX33/ITPR3/TRAF2/IKBKE/RNASEL/SUGT1/IRF9/CYBA/IL18/TXN/NOD1/DNM1L/TRAF5/MCU/GBP5/BIRC2/FADD/ANTXR1/VDAC1/TAB2/IFI16/RIPK3/STAT2/PLCB1/IFNAR1/TNF/NEK7/TRPV2/CASP4/OAS2/MAP1LC3C/PYCARD/PRKCD/MAP1LC3A/ITPR1/TICAM1/GBP4/TRAF3/CASP1/STAT1/IFNA21/CARD16/MAPK10/IRF7/ERBIN/MAPK13/CARD6/OAS3/TLR4/NOD2/PLCB4/P2RX7/OAS1/NAMPT/AIM2/GABARAPL1/TXNIP/PANX1/NFKB1/IFNAR2/CCL2/GBP1/JUN/PKN2/GBP3/CXCL1/CXCL3/CXCL8/CXCL2/CCL5/GBP2/NFKBIA/RIPK2	161
KEGG	hsa01523	Antifolate resistance	28/6848	30/8135	0.125	0.18	0.07716	SLC19A1/FOLR2/SLC46A1/IKBKG/IKBKB/MTHFR/FPGS/FOLR1/ALOX12/CHUK/SHMT1/GART/RELA/ATIC/DHFR2/FOLR3/SHMT2/ABCC4/ABCG2/ABCC2/ABCC3/TNF/ABCC1/GGH/TYMS/ABCC5/DHFR/NFKB1	28
KEGG	hsa04668	TNF signaling pathway	99/6848	112/8135	0.1339	0.1919	0.08226	ATF2/MAPK11/TAB3/MAP2K7/MAPK12/CREB3L3/MAPK1/AKT2/CASP10/IFNB1/MAPK14/CREB1/TNFRSF1A/MAPK3/MAPK9/TAB1/AKT1/IKBKG/IKBKB/TRADD/RPS6KA4/MAP2K4/PIK3R2/ATF6B/CASP8/DAB2IP/MAP3K7/AKT3/BAG4/CREB3L1/CHUK/PGAM5/CREB3/MAPK8/CSF1/RELA/RIPK1/PIK3CB/CASP3/TRAF2/PIK3R3/PIK3R1/ATF4/DNM1L/MMP14/TRAF5/CREB3L4/MAP2K1/BIRC2/FADD/MMP9/RPS6KA5/TAB2/MLKL/RIPK3/CREB3L2/MAP2K6/TNF/PIK3CA/MAP3K14/PIK3CD/FAS/TRAF3/MAPK10/CEBPB/MAPK13/ITCH/CASP7/CREB5/VEGFC/SOCS3/MAP2K3/BCL3/NOD2/JAG1/CFLAR/IL18R1/VEGFD/JUNB/VCAM1/NFKB1/CCL2/TRAF1/JUN/CCL20/CX3CL1/TNFRSF1B/MAP3K5/CXCL1/FOS/CXCL3/CXCL2/CCL5/IL15/IRF1/NFKBIA/EDN1/CXCL6/ICAM1	99
KEGG	hsa01230	Biosynthesis of amino acids	67/6848	75/8135	0.1406	0.2007	0.08601	ALDOB/IDH3G/TKTL1/PGAM2/CS/IDH3B/TKTL2/PAH/OTC/PKLR/MAT1A/ACO2/SDS/GAPDH/ARG1/PRPS1L1/GOT2/NAGS/GOT1L1/PGK2/PKM/PFKL/ENO3/SHMT1/PYCR2/ALDOA/GPT/ASL/RPE/PGAM1/IDH2/MAT2A/SDSL/BCAT2/ALDH18A1/TALDO1/PRPS2/PGK1/MTR/IDH3A/PFKM/GLUL/TKT/SHMT2/ENO1/RPIA/CBS/ACO1/PYCR3/PYCR1/ALDOC/PRPS1/GPT2/GOT1/IDH1/CTH/CPS1/ARG2/ENO2/BCAT1/PHGDH/PC/PFKP/PSPH/ASS1/ASNS/PSAT1	67
KEGG	hsa00600	Sphingolipid metabolism	47/6848	52/8135	0.1477	0.21	0.09001	SPTLC1/SMPD3/UGT8/NEU4/CERS3/NEU3/SMPD4/PSAP/B4GALNT1/GBA2/PSAPL1/CERS2/CERS5/DEGS1/GAL3ST1/SPHK2/SMPD1/ENPP7/SMPD2/GLB1/NEU1/CERS4/SGPP2/ASAH1/HEXB/SGMS2/SGPP1/CERS1/CERS6/HEXA/PLPP2/DEGS2/GALC/CERK/GLA/SGPL1/ACER3/B4GALT6/PLPP3/SGMS1/SPTLC2/SPTLC3/KDSR/PLPP1/UGCG/ARSA/SPHK1	47
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	11/6848	11/8135	0.1502	0.2118	0.0908	TAT/COQ7/VKORC1/HPD/VKORC1L1/GGCX/COQ5/COQ6/COQ2/COQ3/NQO1	11
KEGG	hsa05152	Tuberculosis	157/6848	180/8135	0.1515	0.2118	0.0908	CLEC7A/CR1/SYK/CD209/HLA-DQB1/CLEC4M/HLA-DOA/MAPK11/HLA-DQA1/ATP6V0C/PPP3CB/CIITA/CAMK2B/ATP6V0A1/ATP6V0D2/NOS2/LAMP1/PPP3R2/RAB5C/BCL2/MAPK12/IFNA6/CAMP/MAPK1/NFYC/ATP6V0D1/TIRAP/CALML4/AKT2/CASP10/CLEC4E/IFNB1/TLR6/ATP6V0A4/FCGR2B/RAB5A/MAPK14/CREB1/BAD/TNFRSF1A/IFNA2/IL10RA/MAPK3/SRC/ITGAX/TRAF6/MAPK9/IFNG/KSR1/IFNA5/RAF1/CALM2/IL12B/AKT1/TRADD/ATP6AP1/RAB7A/RHOA/RAB5B/FCGR2A/CALML6/NFYA/PIK3C3/RFXANK/IFNA1/IRAK1/TGFB1/CALM3/SPHK2/IRAK4/CASP8/CARD9/CD74/IFNA14/ITGAM/MRC2/FCGR3B/ARHGEF12/AKT3/TCIRG1/CORO1A/CR1L/MRC1/CALML3/FCER1G/FCGR2C/IFNA16/TGFB3/CASP9/IFNA8/CALML5/CYP27B1/MAPK8/CREBBP/CAMK2A/RELA/MYD88/IL10/EEA1/CASP3/JAK1/APAF1/LBP/PPP3CA/ATP6V1H/CAMK2G/LAMP2/IL18/ATP6V0B/HSPD1/BCL10/ATP6V0A2/EP300/CALM1/MALT1/BAX/FADD/HLA-DPA1/RFX5/NFYB/IFNGR1/TNF/PLA2R1/CAMK2D/CYCS/TLR2/CEBPG/IL10RB/STAT1/RFXAP/IFNA21/PLK3/MAPK10/IL12A/LSP1/VDR/HSPA9/HLA-DRA/CEBPB/MAPK13/JAK2/TLR4/NOD2/IL23A/TLR1/IFNGR2/ITGB2/TGFB2/CD14/SPHK1/C3/IRAK2/NFKB1/PPP3R1/CTSS/BID/RIPK2	157
KEGG	hsa00100	Steroid biosynthesis	19/6848	20/8135	0.1516	0.2118	0.0908	CEL/SC5D/LSS/SOAT2/CYP27B1/FDFT1/EBP/MSMO1/NSDHL/CYP51A1/DHCR7/TM7SF2/LBR/SQLE/SOAT1/LIPA/CYP2R1/DHCR24/CYP24A1	19
KEGG	hsa00670	One carbon pool by folate	19/6848	20/8135	0.1516	0.2118	0.0908	ALDH1L1/FTCD/MTHFR/MTHFS/SHMT1/GART/MTHFD1L/MTHFD1/ATIC/MTR/DHFR2/SHMT2/ALDH1L2/MTFMT/MTHFD2L/AMT/MTHFD2/TYMS/DHFR	19
KEGG	hsa04370	VEGF signaling pathway	53/6848	59/8135	0.1543	0.2147	0.09201	MAPK11/PTK2/PPP3CB/PRKCG/PRKCB/PPP3R2/MAPK12/MAPK1/PLA2G4F/AKT2/NOS3/RAC3/KRAS/MAPK14/BAD/PLCG2/MAPK3/SRC/RAF1/AKT1/PLCG1/RAC1/PIK3R2/NFATC2/MAPKAPK2/SPHK2/SH2D2A/AKT3/MAP2K2/PRKCA/CASP9/HSPB1/MAPKAPK3/PIK3CB/PLA2G4C/PXN/PPP3CA/HRAS/PIK3R3/NRAS/PIK3R1/MAP2K1/KDR/CDC42/RAC2/SHC2/PIK3CA/PIK3CD/VEGFA/MAPK13/SPHK1/PPP3R1/PLA2G4A	53
KEGG	hsa05131	Shigellosis	214/6848	247/8135	0.1617	0.2241	0.09606	SKP1/RPS27A/NLRP3/HKDC1/PLCB2/NLRC4/SEPTIN2/MAPK11/PTK2/CYTH4/UBB/AKT1S1/TAB3/UBA52/IRF3/ATG5/ROCK1/FBXW11/CGAS/UBC/TP53/MAP1LC3B/RPS6KB1/UBE2D2/BCL2/CUL1/CAPNS1/MAPK12/MAPK1/SHARPIN/ITGB1/AKT2/BCL2L1/ILK/DOCK1/MYL10/IFNB1/ATG16L1/GSK3A/BECN1/MAPK14/SEPTIN12/BTRC/UBE2D3/TNFRSF1A/EGFR/PLCG2/ELMO2/HK3/BCAR1/MAPK3/CTTN/SRC/ROCK2/MYL2/TRAF6/MAPK9/TAB1/MYLPF/MYL12B/PLCZ1/AKT1/IKBKG/IKBKB/PLCD1/PLCG1/TLN1/TRADD/RRAGA/RAC1/RHOA/CAPN1/PRKCQ/RPS6KB2/PIK3R2/IL1R1/RBCK1/PIK3C3/CBX3/PLCB3/ARF1/WIPI2/GLMN/PRKCE/MYL12A/CALCOCO2/ACTB/UBE2D4/RRAGC/FOXO4/MAP3K7/ITGA5/AKT3/SEPTIN8/CYTH1/ACTN4/CYTH3/SEPTIN7/CAPN2/ACTR3/PFN4/MYL5/RPTOR/ACTR3B/DIAPH1/ATG12/CRKL/CHUK/ARPC5/ITPR2/ARPC2/MAPK8/PLCD3/WASF2/ATM/CYTH2/TBK1/HK1/RELA/RNF31/CRK/MYD88/RIPK1/MDM2/VCL/UBE2V2/PIK3R4/PIK3CB/NFKBIB/ACTG1/U2AF1L4/SEPTIN9/SEPTIN3/TLN2/U2AF1/PPID/ITPR3/TLR5/PXN/TRAF2/GSK3B/ACTR2/ARPC1A/MYL9/PFN1/PIK3R3/ACTR3C/IL18/ARPC1B/UBE2D1/PFN2/BCL10/PIK3R1/NOD1/FOXO3/MALT1/UBE2N/TRAF5/ARHGEF2/PLCD4/ARPC3/ARPC4/CD44/BAX/ARPC5L/VDAC1/RPS6KA5/TAB2/MTOR/CDC42/PLCB1/TNF/SEPTIN6/TECPR1/CASP4/PIK3CA/ARF6/MAP1LC3C/PYCARD/SEPTIN11/PIK3CD/CYCS/PRKCD/WASF1/MAP1LC3A/ITPR1/CASP1/ACTN1/BNIP3/HK2/MAPK10/WASL/FOXO1/FNBP1/MAPK13/TLR4/PLCE1/PLCB4/ELMO1/RRAGB/WIPI1/RRAGD/HCLS1/FNBP1L/CD14/C3/NFKB1/JUN/TNIP1/CXCL8/CCL5/TIFA/NFKBIA/RIPK2	214
KEGG	hsa04659	Th17 cell differentiation	95/6848	108/8135	0.1711	0.2361	0.1012	IL22/RORC/HLA-DQB1/HLA-DOA/JAK3/IL12RB1/IL23R/MAPK11/HLA-DQA1/PPP3CB/IL2RG/IL17A/SMAD4/FOXP3/SMAD2/IL2RA/IL4/PPP3R2/CD3E/RARA/ZAP70/MAPK12/MAPK1/STAT6/RXRB/MAPK14/IL2/IRF4/CD3G/IL21/MAPK3/MAPK9/IFNG/RUNX1/RXRG/IKBKG/IKBKB/GATA3/IL2RB/CD4/PLCG1/IL17F/LCK/TBX21/CD3D/PRKCQ/TYK2/IL1R1/TGFBR2/IL21R/EBI3/NFATC2/RXRA/TGFB1/HSP90AA1/HSP90AB1/IL27/HIF1A/STAT5B/CHUK/MAPK8/RELA/SMAD3/LAT/STAT3/NFKBIB/JAK1/TGFBR1/PPP3CA/NFATC3/IL27RA/HLA-DPA1/MTOR/IFNGR1/IL6ST/STAT1/CD247/IL6R/IL1RAP/MAPK10/HLA-DRA/MAPK13/JAK2/IL4R/IL23A/IFNGR2/RORA/AHR/NFATC1/NFKB1/PPP3R1/JUN/NFKBIE/FOS/NFKBIA	95
KEGG	hsa00510	N-Glycan biosynthesis	45/6848	50/8135	0.1754	0.2411	0.1033	ALG12/ST6GAL2/MGAT3/MGAT4A/MGAT5B/GANAB/MGAT5/MAN1B1/MAN1A2/MGAT4C/MGAT4B/ALG9/DDOST/DOLK/MAN2A2/ALG3/ALG10/MAN2A1/ALG5/B4GALT2/ALG13/B4GALT3/ALG8/ALG6/STT3B/B4GALT1/DPM2/DPM3/DAD1/DPM1/ALG10B/RPN2/DOLPP1/ALG2/ALG14/DPAGT1/SRD5A3/ST6GAL1/MOGS/MGAT2/MAN1A1/FUT8/RPN1/STT3A/MAN1C1	45
KEGG	hsa00920	Sulfur metabolism	10/6848	10/8135	0.1785	0.2443	0.1047	BPNT1/PAPSS1/ETHE1/IMPAD1/SUOX/MPST/TST/SQOR/SELENBP1/PAPSS2	10
KEGG	hsa00190	Oxidative phosphorylation	117/6848	134/8135	0.1901	0.2591	0.1111	ATP12A/ATP6V1C2/NDUFA11/ATP6V0C/COX8C/ATP6V0A1/ATP6V1F/ATP6V0D2/ATP5F1C/NDUFS3/ATP6V0E1/ATP6V1B1/NDUFA10/ATP5PB/UQCRFS1/NDUFC2/ATP4B/ATP6V0D1/COX4I1/NDUFV1/SDHC/ATP6V0A4/ATP5PF/COX6A1/UQCRC1/ATP5F1A/UQCR10/ATP5MG/COX15/NDUFB4/ATP6V1G3/UQCRH/COX6B1/NDUFS4/NDUFB8/NDUFB9/COX7B2/NDUFB10/ATP6V1D/NDUFA13/NDUFA8/COX5B/COX8A/ATP6V1E1/ATP6AP1/NDUFA9/NDUFB5/COX5A/ATP5MF/SDHD/ATP5F1D/ATP5PD/UQCR11/COX2/SDHB/NDUFS7/NDUFB2/ND4/NDUFA2/ATP5F1B/NDUFA6/COX6B2/NDUFB6/COX4I2/NDUFB3/COX7A2L/LHPP/UQCRQ/NDUFA1/TCIRG1/NDUFA5/COX7C/ATP5ME/UQCRB/SDHA/COX10/NDUFB7/COX6C/NDUFB11/ATP4A/ATP6V1G2/NDUFA12/NDUFA3/ATP6V1E2/NDUFC1/ATP5F1E/NDUFS2/PPA1/NDUFB1/ATP6V1C1/ATP5MC3/NDUFV2/ATP5MC2/COX11/NDUFS5/NDUFA7/CYC1/ATP6V1A/COX7A2/ATP6V1G1/NDUFS1/ATP6V1H/ATP6V1B2/ATP6V0B/NDUFS8/ATP6V0A2/ATP5MC1/PPA2/ND5/COX7B/COX17/NDUFV3/ATP6V0E2/CYCS/COX7A1/NDUFA4/NDUFA4L2	117
KEGG	hsa00790	Folate biosynthesis	24/6848	26/8135	0.1968	0.2672	0.1145	ALPI/ALPG/TPH2/PAH/ALPP/SPR/TH/MOCS1/FPGS/GPHN/PCBD1/MOCS2/PTS/CBR1/PCBD2/AKR1B10/QDPR/DHFR2/ALPL/GGH/MOCOS/AKR1C3/AKR1B1/DHFR	24
KEGG	hsa04216	Ferroptosis	37/6848	41/8135	0.2007	0.2714	0.1163	CYBB/TF/ATG5/TP53/MAP1LC3B/ATG7/FTL/ACSL6/VDAC3/VDAC2/PCBP2/NCOA4/TFRC/LPCAT3/ALOX15/GSS/PRNP/GPX4/SLC39A14/SLC3A2/GCLM/ACSL1/FTH1/GCLC/MAP1LC3C/SAT2/MAP1LC3A/SAT1/ACSL5/STEAP3/SLC39A8/SLC7A11/ACSL3/SLC11A2/HMOX1/SLC40A1/CP	37
KEGG	hsa04114	Oocyte meiosis	114/6848	131/8135	0.2213	0.298	0.1277	SKP1/STAG3/MAPK11/PPP2R1A/PPP3CB/ANAPC11/CAMK2B/ANAPC5/PRKACB/YWHAE/PPP3R2/SMC1A/FBXW11/SPDYA/ANAPC1/ANAPC2/INS/CUL1/PRKACA/MAPK12/FBXO43/MAPK1/CALML4/YWHAQ/ANAPC7/MAPK14/BTRC/MAPK3/PPP1CC/PLK1/PPP2R5D/CALM2/PLCZ1/CDC25C/CDC16/ANAPC15/ADCY2/ANAPC4/ADCY1/PPP1CB/PPP2R5C/CALML6/PPP2CB/ADCY9/CDK2/CALM3/CDC27/PPP2R5E/ADCY5/PTTG2/PPP2R1B/PPP2R5A/ANAPC13/PPP1CA/SGO1/CALML3/PRKACG/CDC26/ADCY3/MOS/MAD1L1/ITPR2/YWHAG/CALML5/RPS6KA6/PPP2R5B/YWHAB/RPS6KA1/MAD2L2/CAMK2A/ADCY6/PGR/ANAPC16/SLK/AR/ANAPC10/ADCY7/ITPR3/FBXO5/PPP3CA/CAMK2G/RPS6KA2/PPP2CA/CALM1/MAP2K1/REC8/BUB1/YWHAH/CPEB3/CDC23/IGF1R/CAMK2D/CCNE1/ADCY8/ITPR1/SMC3/SMC1B/CDC20/AURKA/CDK1/PTTG1/RPS6KA3/MAPK13/CCNB1/CCNB2/ESPL1/ADCY4/CCNE2/CPEB1/CPEB4/MAD2L1/CPEB2/PPP3R1/IGF1	114
KEGG	hsa03420	Nucleotide excision repair	42/6848	47/8135	0.2245	0.3011	0.1291	ERCC8/CUL4A/GTF2H1/CDK7/CETN2/ERCC3/POLE/POLD4/RAD23A/DDB1/RPA4/LIG1/RFC1/ERCC4/CCNH/ERCC2/POLD1/RAD23B/POLD2/RPA1/GTF2H3/RPA3/POLE4/XPA/RFC3/POLE3/GTF2H5/GTF2H4/MNAT1/ERCC5/RFC5/CUL4B/ERCC1/RPA2/POLD3/PCNA/RFC2/XPC/POLE2/RFC4/ERCC6/DDB2	42
KEGG	hsa00640	Propanoate metabolism	29/6848	32/8135	0.2317	0.3071	0.1316	LDHAL6B/ACACA/ECHS1/SUCLG1/ECHDC1/DLD/SUCLA2/ACADS/BCKDHA/HADHA/LDHB/PCCB/MLYCD/LDHA/ACSS2/SUCLG2/LDHC/DBT/EHHADH/HIBCH/ACACB/MMUT/BCKDHB/ALDH6A1/ACSS3/PCCA/ACOX1/MCEE/ABAT	29
KEGG	hsa04136	Autophagy - other	29/6848	32/8135	0.2317	0.3071	0.1316	ATG4B/ATG5/ATG7/ATG16L1/BECN1/ATG4D/MLST8/ATG9B/PIK3C3/PPP2CB/WIPI2/ATG3/ATG9A/ATG2B/GABARAP/RPTOR/ATG4A/ATG12/ATG101/PIK3R4/GABARAPL2/PPP2CA/ATG4C/ATG2A/MTOR/IGBP1/ULK2/WIPI1/GABARAPL1	29
KEGG	hsa04215	Apoptosis - multiple species	29/6848	32/8135	0.2317	0.3071	0.1316	BCL2/BCL2L1/SEPTIN4/BECN1/DIABLO/TNFRSF1A/MAPK9/CASP8/BCL2L11/HTRA2/BIRC6/BIRC7/CASP9/MAPK8/XIAP/CASP3/APAF1/BBC3/BIRC2/BAX/FADD/BAK1/BOK/CYCS/BIRC5/MAPK10/CASP7/PMAIP1/BID	29
KEGG	hsa04977	Vitamin digestion and absorption	22/6848	24/8135	0.2442	0.3224	0.1382	SLC52A3/PNLIP/SLC19A1/APOB/APOA4/SLC46A1/RBP2/SLC23A1/APOA1/CBLIF/CUBN/PLB1/SCARB1/TCN2/FOLH1/BTD/LMBRD1/MMACHC/SLC19A3/SLC5A6/ABCC1/SLC19A2	22
KEGG	hsa04514	Cell adhesion molecules	129/6848	149/8135	0.2473	0.3252	0.1394	CD6/PTPRC/NRXN1/SPN/CD22/ITGAL/HLA-DQB1/CTLA4/HLA-DOA/NLGN3/CLDN18/CD86/HLA-DQA1/NLGN4Y/CLDN19/MAG/CD8B/NECTIN1/TIGIT/CD28/CD80/JAM3/CNTN2/NCAM1/CLDN3/ITGA9/CD2/NLGN2/SELP/ITGB1/CDH1/MADCAM1/CLDN8/CLDN6/CD8A/VTCN1/CLDN7/LRRC4B/CD226/IGSF11/CLDN10/CD276/CD40LG/SELPLG/CLDN5/CD4/SIGLEC1/CNTNAP2/ESAM/CDH3/CLDN17/CLDN15/ITGB7/PVR/NRCAM/PDCD1/CLDN4/F11R/CLDN2/NECTIN2/ICOSLG/ITGAM/LRRC4/SELL/CLDN9/CDH15/CNTN1/CADM3/CLDN16/CD99L2/CD99/ICOS/HLA-G/MPZ/CNTNAP1/NCAM2/NFASC/CLDN11/CLDN20/ITGAV/NEGR1/SDC2/SDC3/ITGA8/PTPRM/PECAM1/MPZL1/VCAN/CDH4/NTNG1/GLG1/ICAM3/PTPRF/HLA-DPA1/HLA-F/NEO1/NRXN2/L1CAM/NECTIN3/ITGA4/HLA-E/JAM2/VSIR/CD40/ICAM2/PDCD1LG2/NTNG2/HLA-DRA/CD34/SDC1/ITGB8/ITGA6/ALCAM/NRXN3/NLGN1/CDH5/CDH2/CD58/ITGB2/SDC4/LRRC4C/CLDN14/VCAM1/CD274/NLGN4X/CLDN23/CADM1/CLDN1/ICAM1	129
KEGG	hsa00360	Phenylalanine metabolism	15/6848	16/8135	0.2545	0.3333	0.1429	ALDH3B2/PAH/ALDH3A1/TAT/GOT2/HPD/GOT1L1/MIF/AOC2/ALDH3B1/GOT1/MAOA/AOC3/MAOB/IL4I1	15
KEGG	hsa03022	Basal transcription factors	40/6848	45/8135	0.2625	0.3425	0.1468	GTF2I/TAF7/GTF2A2/TAF6/GTF2A1/GTF2H1/TAF9B/CDK7/GTF2F1/TAF2/TBP/TAF11/TAF7L/GTF2A1L/ERCC3/TAF8/TAF9/CCNH/ERCC2/GTF2E2/TAF4/TAF1L/TAF1/TAF6L/GTF2H3/TAF12/TBPL1/TAF5L/TAF10/GTF2H5/GTF2H4/MNAT1/GTF2F2/GTF2B/TAF15/TAF5/TAF4B/GTF2IRD1/GTF2E1/TAF3	40
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	27/6848	30/8135	0.2788	0.3623	0.1553	AGXT/CS/ACO2/GLYCTK/HAO2/DLD/ACAT1/MDH1/GRHPR/PCCB/GLDC/AFMID/SHMT1/ACSS2/MDH2/HYI/MMUT/GLUL/GCSH/SHMT2/ACO1/PCCA/ACAT2/AMT/MCEE/CAT/HOGA1	27
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	14/6848	15/8135	0.2882	0.3731	0.1599	FUT9/FUT2/FUT1/B3GALT5/NAGA/HEXB/ST3GAL2/HEXA/GLA/B3GALNT1/GBGT1/A4GALT/ST3GAL1/ST8SIA1	14
KEGG	hsa00220	Arginine biosynthesis	20/6848	22/8135	0.3004	0.3874	0.166	GLS2/NOS1/NOS2/OTC/NOS3/ARG1/GOT2/NAGS/GOT1L1/GLUD2/GPT/ASL/GLUD1/GLS/GLUL/GPT2/GOT1/CPS1/ARG2/ASS1	20
KEGG	hsa04622	RIG-I-like receptor signaling pathway	61/6848	70/8135	0.3122	0.401	0.1719	TKFC/MAPK11/IRF3/ATG5/DDX3X/MAPK12/IFNA6/OTUD5/CASP10/IFNB1/MAPK14/PIN1/IFNA2/TRAF6/MAPK9/IFNA5/IL12B/IKBKG/IKBKB/TRADD/SIKE1/NLRX1/IFNA1/CASP8/MAP3K7/IFNA14/IFNW1/ATG12/IFNA16/CHUK/IFNA8/MAPK8/TBK1/MAVS/RELA/RIPK1/RNF125/NFKBIB/TANK/MAP3K1/TRAF2/IKBKE/AZI2/TRIM25/FADD/TNF/DHX58/TRAF3/IFNA21/MAPK10/IL12A/IRF7/MAPK13/ISG15/IFNE/DDX58/CYLD/IFIH1/NFKB1/CXCL8/NFKBIA	61
KEGG	hsa00650	Butanoate metabolism	25/6848	28/8135	0.3325	0.4255	0.1824	HMGCLL1/GAD2/GAD1/HMGCS2/ACSM3/L2HGDH/OXCT2/ACSM2A/ECHS1/ACSM1/ACAT1/ACADS/HADHA/AACS/BDH1/HMGCL/ALDH5A1/ACSM5/EHHADH/HADH/ACAT2/OXCT1/BDH2/HMGCS1/ABAT	25
KEGG	hsa04914	Progesterone-mediated oocyte maturation	88/6848	102/8135	0.3366	0.4291	0.1839	FZR1/MAPK11/ANAPC11/ANAPC5/PRKACB/SPDYA/ANAPC1/ANAPC2/INS/PRKACA/MAPK12/ARAF/MAPK1/AKT2/ANAPC7/KRAS/MAPK14/CCNB3/GNAI3/MAPK3/PLK1/MAPK9/RAF1/CDC25C/AKT1/CDC16/PDE3B/ANAPC15/ADCY2/ANAPC4/ADCY1/PIK3R2/ADCY9/CDK2/HSP90AA1/CDC27/HSP90AB1/ADCY5/AKT3/KIF22/ANAPC13/GNAI2/BRAF/PRKACG/CDC26/ADCY3/MOS/MAD1L1/RPS6KA6/MAPK8/RPS6KA1/MAD2L2/ADCY6/PGR/ANAPC16/PIK3CB/ANAPC10/ADCY7/RPS6KA2/PIK3R3/PIK3R1/MAP2K1/CDC25A/BUB1/CPEB3/PIK3CA/STK10/CDC23/IGF1R/CDC25B/ADCY8/PIK3CD/CCNA2/AURKA/CDK1/CCNA1/MAPK10/RPS6KA3/MAPK13/GNAI1/CCNB1/CCNB2/ADCY4/CPEB1/CPEB4/MAD2L1/CPEB2/IGF1	88
KEGG	hsa04664	Fc epsilon RI signaling pathway	59/6848	68/8135	0.3491	0.4434	0.19	SYK/ALOX5/BTK/MAPK11/INPP5D/FCER1A/IL4/MAP2K7/MAPK12/MS4A2/MAPK1/PLA2G4F/AKT2/RAC3/KRAS/MAPK14/PDPK1/PLCG2/MAPK3/MAPK9/VAV2/RAF1/AKT1/VAV1/PLCG1/RAC1/MAP2K4/ALOX5AP/PIK3R2/GRB2/AKT3/MAP2K2/PRKCA/FCER1G/IL13/MAPK8/LAT/PIK3CB/SOS2/PLA2G4C/HRAS/PIK3R3/VAV3/SOS1/NRAS/PIK3R1/MAP2K1/RAC2/MAP2K6/TNF/PIK3CA/PIK3CD/FYN/MAPK10/MAPK13/MAP2K3/GAB2/LYN/PLA2G4A	59
KEGG	hsa03460	Fanconi anemia pathway	47/6848	54/8135	0.3621	0.4581	0.1964	POLK/TOP3B/TOP3A/FANCD2/SLX4/FANCM/FAAP100/FANCB/FANCA/MUS81/REV1/FAAP24/RPA4/ERCC4/FANCC/POLN/TELO2/MLH1/RPA1/RAD51/RPA3/BLM/BRCA1/ATR/POLH/WDR48/ATRIP/RAD51C/BRCA2/FANCF/CENPS/BRIP1/EME1/USP1/CENPX/FANCG/ERCC1/FANCI/RPA2/RMI1/FANCE/POLI/FANCL/RMI2/UBE2T/REV3L/HES1	47
KEGG	hsa04973	Carbohydrate digestion and absorption	41/6848	47/8135	0.3691	0.4652	0.1994	HKDC1/PLCB2/ATP1A4/CACNA1D/PRKCB/SI/FXYD2/SLC5A1/ATP1A2/ATP1B4/ATP1B2/GNAT3/AKT2/HK3/ATP1A1/G6PC2/SLC37A4/AKT1/G6PC/SLC2A2/ATP1B3/PIK3R2/PLCB3/ATP1A3/LCT/G6PC3/AKT3/TAS1R2/HK1/PIK3CB/PIK3R3/PIK3R1/PLCB1/PIK3CA/PIK3CD/SLC2A5/HK2/MGAM/AMY2B/PLCB4/ATP1B1	41
KEGG	hsa04145	Phagosome	130/6848	152/8135	0.3726	0.4678	0.2005	CLEC7A/NOS1/CD209/MSR1/FCAR/HLA-DQB1/CYBB/CLEC4M/HLA-DOA/TUBB1/ATP6V1C2/HLA-DQA1/ATP6V0C/ATP6V0A1/MPO/ATP6V1F/ATP6V0D2/SEC61A2/LAMP1/NCF4/ATP6V0E1/RAB5C/ATP6V1B1/ATP6V0D1/DYNC1I2/ITGB1/TLR6/PIKFYVE/ATP6V0A4/FCGR2B/RAB5A/MARCO/DYNC1H1/ATP6V1G3/TUBAL3/DYNC1LI1/ATP6V1D/ATP6V1E1/ATP6AP1/RAB7A/MBL2/RAC1/TFRC/DYNC1I1/RAB5B/HGS/FCGR2A/PIK3C3/SCARB1/ITGB3/VAMP3/TUBA8/ACTB/DYNC1LI2/TUBA3C/ITGA5/ITGAM/MRC2/FCGR3B/TCIRG1/CORO1A/SFTPA2/NCF1/TUBB4A/MRC1/TUBA1A/FCGR2C/ATP6V1G2/ATP6V1E2/HLA-G/C1R/SFTPD/SEC61A1/ATP6V1C1/TUBB/SEC61B/EEA1/STX7/ACTG1/CALR/M6PR/ATP6V1A/STX12/ATP6V1G1/ATP6V1H/THBS3/DYNC2H1/ATP6V1B2/ITGAV/LAMP2/CYBA/OLR1/CTSL/ATP6V0B/RILP/ATP6V0A2/RAB7B/TUBA1C/HLA-DPA1/HLA-F/TUBA1B/COLEC11/TUBB4B/ITGB5/PLA2R1/NCF2/ATP6V0E2/TUBB3/THBS2/TLR2/TUBB6/HLA-E/TUBA4A/HLA-DRA/TAP1/SEC61G/TLR4/COMP/TUBB2A/THBS1/ITGB2/TAP2/CD14/COLEC12/ITGA2/C3/CTSS/CD36/TUBB2B/SEC22B	130
KEGG	hsa04950	Maturity onset diabetes of the young	23/6848	26/8135	0.393	0.4916	0.2107	NR5A2/PAX4/HNF1B/MNX1/PDX1/FOXA2/HNF4A/PAX6/INS/PKLR/NEUROG3/HNF4G/HNF1A/NEUROD1/IAPP/RFX6/SLC2A2/NKX2-2/NKX6-1/ONECUT1/FOXA3/HHEX/HES1	23
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	17/6848	19/8135	0.4022	0.4997	0.2142	IDH3G/CS/IDH3B/ACO2/GOT2/NAGS/GOT1L1/GPT/AADAT/IDH2/BCAT2/IDH3A/ACO1/GPT2/GOT1/IDH1/BCAT1	17
KEGG	hsa00513	Various types of N-glycan biosynthesis	34/6848	39/8135	0.4025	0.4997	0.2142	ALG12/ST3GAL3/B4GALNT3/MGAT4A/B4GALNT4/MAN1B1/MAN1A2/MGAT4C/CHST8/CHST9/MGAT4B/ALG9/HEXD/DDOST/MAN2A2/HEXB/ALG3/MAN2A1/B4GALT2/ALG13/B4GALT3/HEXA/STT3B/B4GALT1/DAD1/RPN2/ALG2/ALG14/MGAT2/MAN1A1/FUT8/RPN1/STT3A/MAN1C1	34
KEGG	hsa00480	Glutathione metabolism	50/6848	58/8135	0.419	0.5183	0.2221	GGT6/GPX5/GPX2/NAT8/GGT7/GSTA1/GSTP1/GGT1/LANCL1/G6PD/GSS/HPGDS/PRDX6/TXNDC12/NAT8B/GSTA3/GSTM4/OPLAH/IDH2/MGST3/GGCT/GSTO2/GGT5/GPX4/GSTM1/GSR/GSTK1/PGD/GPX1/GSTA4/MGST1/GSTO1/GPX8/GPX3/GCLM/IDH1/ODC1/GCLC/GPX7/RRM2B/SRM/LAP3/ANPEP/CHAC1/CHAC2/MGST2/RRM2/GSTM3/GSTM5/SMS	50
KEGG	hsa04060	Cytokine-cytokine receptor interaction	250/6848	295/8135	0.4311	0.5313	0.2277	CSF2RA/IL37/IL5RA/EPOR/CXCR3/BMP7/IL22/THPO/IL17C/EDA/IL17RC/BMP8B/CRLF2/GH1/CXCR6/CXCL17/BMP8A/CSF3R/ACVR1B/IL12RB1/TNFSF11/FASLG/EPO/IL23R/TNFRSF25/IL1F10/CCL23/IL2RG/IL17A/CCL15/XCL1/IL16/IL2RA/CCL25/CCL24/IL4/IL31RA/CCR2/INHA/TNFRSF10C/GDF9/IFNA6/IL9R/GH2/IL18RAP/CXCR5/TNFRSF13B/GDF2/CCR5/AMHR2/IL17RE/IFNB1/GDF3/IFNLR1/IFNL1/TNFRSF17/IL1R2/IL20/CXCL13/IL2/LTBR/TNFRSF1A/IL21/TNFRSF8/IFNA2/NODAL/CCL21/IL17B/IL10RA/MPL/IFNG/IFNA5/CD40LG/CCR9/IL12B/CCR3/CSH2/IL9/CSF1R/CCL16/LTB/IL2RB/CXCR2/IFNL2/PRLR/CD4/IL3RA/XCR1/PRL/IL17F/PPBP/OSM/BMP3/CNTFR/IFNL3/IL1R1/CCL17/CCR8/TGFBR2/IL21R/BMP10/EBI3/IL22RA1/CSH1/EDA2R/IFNA1/TGFB1/BMP5/IL34/CCL22/IFNA14/CX3CR1/CCR6/IL13RA1/CCR4/CCL27/CCL19/TNFRSF13C/IFNW1/IL17RA/BMP15/IL27/IFNA16/IL36A/IL36B/TGFB3/IL13/CCL28/EDAR/IFNA8/TNFRSF11A/CSF1/CNTF/IL19/OSMR/TNFSF8/TNFSF18/CCL18/ACVR2B/CXCL9/GDF11/TNFRSF14/IL10/IL1RL2/CXCR1/TNFRSF10B/ACVR1C/CCL1/TNFSF14/CCR10/CCR7/TGFBR1/TNFSF12/CD27/IL36G/IL12RB2/LEP/ACVR1/IL1RN/IL25/TNFSF13/IL18/BMPR1A/PF4/TNFRSF4/CXCR4/IL27RA/RELT/IL36RN/INHBE/TNFRSF19/IFNGR1/IL17D/IFNAR1/TNF/PF4V1/IL6ST/LEPR/IL20RA/IL11RA/LIFR/INHBB/CCL26/FAS/CCR1/IL10RB/ACVRL1/CLCF1/IFNA21/IL6R/CXCL12/CD40/TNFRSF18/IL1RAP/CSF2RB/TNFRSF21/IL1RL1/GDF5/IL12A/IL11/BMPR1B/IFNE/IL4R/ACVR2A/TNFRSF12A/GHR/IL23A/BMPR2/IL24/CXCL16/IL18R1/IFNGR2/TNFSF13B/BMP4/BMP6/NGF/CCL13/IL20RB/TGFB2/CXCL14/GDF10/TNFRSF11B/CCL4/GDF15/IL7/IL15RA/CCL11/INHBA/IL13RA2/IFNAR2/ACKR3/CCL2/CCL20/CX3CL1/CSF3/TNFRSF1B/CD70/TNFRSF9/TNFSF4/TNFSF10/CXCL1/CXCL3/CXCL8/IL7R/CXCL2/CCL5/ACKR4/IL15/BMP2/CXCL6	250
KEGG	hsa00061	Fatty acid biosynthesis	16/6848	18/8135	0.4407	0.5392	0.2311	ACSF3/ACSBG1/OLAH/ACACA/ACSL6/ACSBG2/MECR/CBR4/FASN/MCAT/ACACB/HSD17B8/ACSL1/OXSM/ACSL5/ACSL3	16
KEGG	hsa00511	Other glycan degradation	16/6848	18/8135	0.4407	0.5392	0.2311	NEU4/NEU3/GBA2/MAN2C1/HEXD/GLB1/NEU1/HEXB/FUCA2/HEXA/MAN2B1/ENGASE/MAN2B2/MANBA/AGA/FUCA1	16
KEGG	hsa05144	Malaria	43/6848	50/8135	0.454	0.5535	0.2372	CR1/ITGAL/GYPB/SELP/KLRK1/IFNG/CD40LG/CD81/HBA1/ACKR1/TGFB1/HBB/LRP1/HBA2/CR1L/KLRB1/TGFB3/MYD88/IL10/THBS3/IL18/SDC2/PECAM1/GYPC/MET/TNF/THBS2/TLR2/HGF/CD40/IL12A/SDC1/TLR4/COMP/THBS1/ITGB2/TGFB2/VCAM1/CCL2/CSF3/CD36/CXCL8/ICAM1	43
KEGG	hsa05143	African trypanosomiasis	32/6848	37/8135	0.457	0.5551	0.2379	PLCB2/KNG1/FASLG/PRKCG/PRKCB/NPPA/IDO2/APOA1/IFNG/HPR/IL12B/HBA1/PLCB3/HBB/HBA2/LAMA4/PRKCA/GNAQ/MYD88/IL10/IL18/THOP1/PLCB1/TNF/FAS/IL12A/F2RL1/APOL1/PLCB4/VCAM1/IDO1/ICAM1	32
KEGG	hsa00565	Ether lipid metabolism	42/6848	49/8135	0.4784	0.579	0.2482	UGT8/PAFAH1B1/PAFAH1B2/PLA2G12B/PLA2G2D/PLD4/PLA2G10/PLA2G4F/PLA2G2F/PLA2G6/PLA2G3/LPCAT2/PAFAH2/PLB1/PLD2/PLD3/TMEM86B/GAL3ST1/PLA2G1B/PLA2G7/AGPS/PLPP2/PAFAH1B3/PLA2G12A/PLA2G4C/PLPP3/LPCAT1/ENPP6/GDPD3/CHPT1/LPCAT4/GDPD1/SELENOI/CEPT1/PLA2G5/PLPP1/TMEM189/ENPP2/PLD1/PLAAT3/PLA2G2A/PLA2G4A	42
KEGG	hsa00590	Arachidonic acid metabolism	52/6848	61/8135	0.4949	0.595	0.255	ALOX5/GPX5/ALOX12B/CYP2C9/GPX2/PLA2G12B/PLA2G2D/CYP4F3/CYP2C8/CYP2C19/PLA2G10/PLA2G4F/PLA2G2F/CYP4F8/PTGES2/PLA2G6/PLA2G3/TBXAS1/PTGES3/PLB1/CYP2J2/GGT1/ALOX15/ALOX15B/CYP4F2/PLA2G1B/HPGDS/ALOX12/CYP2B6/CYP2E1/CBR1/PLA2G12A/GGT5/PLA2G4C/CYP2U1/PRXL2B/GPX1/GPX8/GPX3/LTA4H/PLA2G5/GPX7/PTGIS/PTGS1/EPHX2/AKR1C3/PLAAT3/PLA2G2A/PTGDS/CBR3/PTGES/PLA2G4A	52
KEGG	hsa04614	Renin-angiotensin system	20/6848	23/8135	0.4953	0.595	0.255	ACE2/KLK2/REN/AGTR2/CMA1/KLK1/ATP6AP2/ACE/CTSG/PREP/LNPEP/CTSA/PRCP/THOP1/MAS1/ANPEP/CPA3/MME/AGT/AGTR1	20
KEGG	hsa04620	Toll-like receptor signaling pathway	88/6848	104/8135	0.5171	0.619	0.2653	CD86/MAPK11/IRF3/TLR7/CD80/TLR8/MAP2K7/MAPK12/IFNA6/MAPK1/TIRAP/AKT2/IRF5/IFNB1/TLR6/MAPK14/IFNA2/MAPK3/TRAF6/MAPK9/IFNA5/TAB1/IL12B/AKT1/IKBKG/IKBKB/TOLLIP/RAC1/MAP2K4/PIK3R2/IFNA1/IRAK1/IRAK4/CASP8/MAP3K7/IFNA14/AKT3/MAP2K2/CTSK/IFNA16/CHUK/IFNA8/MAPK8/TBK1/RELA/MYD88/CXCL9/RIPK1/PIK3CB/LBP/TLR5/IKBKE/PIK3R3/PIK3R1/MAP2K1/LY96/FADD/TAB2/TICAM2/MAP2K6/IFNAR1/TNF/PIK3CA/PIK3CD/TLR3/TICAM1/TLR2/TRAF3/SPP1/STAT1/IFNA21/CD40/MAPK10/IL12A/IRF7/MAPK13/MAP2K3/TLR4/TLR1/CD14/CCL4/NFKB1/IFNAR2/JUN/FOS/CXCL8/CCL5/NFKBIA	88
KEGG	hsa05164	Influenza A	144/6848	171/8135	0.5468	0.6523	0.2796	NLRP3/HLA-DQB1/HLA-DOA/FASLG/HLA-DQA1/RAB11B/CIITA/PRKCB/TMPRSS4/SLC25A31/IRF3/TLR7/HNRNPUL1/TMPRSS2/PLG/IFNA6/MAPK1/PRSS3/AKT2/RAB11A/TPSD1/IFNB1/KPNA6/TNFRSF1A/IFNA2/NXF3/PRSS1/MAPK3/IFNG/IFNA5/RAF1/IL12B/AKT1/CPSF4/IKBKG/IKBKB/SLC25A6/TRADD/NLRX1/TYK2/PIK3R2/TMPRSS11D/IFNA1/IRAK4/CASP8/CALCOCO2/ACTB/TPSAB1/NXT2/ADAR/IFNA14/AKT3/PML/MAP2K2/PRKCA/PABPN1/SLC25A5/CDK4/IFNA16/CHUK/CASP9/NXF1/FDPS/IFNA8/CREBBP/TBK1/MAVS/RAE1/RELA/MYD88/CCND3/SLC25A4/NUP98/PIK3CB/NFKBIB/PRSS2/TNFRSF10B/CASP3/JAK1/APAF1/KPNA5/ACTG1/IKBKE/RNASEL/PIK3R3/IRF9/EIF2S1/KPNA1/IL18/EIF2AK2/PIK3R1/EP300/XPO1/NXT1/MAP2K1/TRIM25/BAX/DNAJB1/FADD/VDAC1/HLA-DPA1/STAT2/IFNGR1/BAK1/IFNAR1/TNF/PIK3CA/OAS2/KPNA2/PYCARD/PIK3CD/CYCS/FAS/TLR3/TICAM1/TRAF3/CASP1/STAT1/IFNA21/IL12A/IRF7/HLA-DRA/CDK6/JAK2/OAS3/DNAJC3/SOCS3/TLR4/DDX58/OAS1/IFNGR2/MX1/RSAD2/MX2/IFIH1/NFKB1/IFNAR2/CCL2/BID/TNFSF10/CXCL8/CCL5/NFKBIA/ICAM1	144
KEGG	hsa05171	Coronavirus disease - COVID-19	195/6848	232/8135	0.5653	0.672	0.288	SYK/RPS27A/NLRP3/ACE2/RPS23/RPL7A/RPS16/RPS28/RPS4X/CYBB/RPL28/RPS13/RPLP0/MASP2/FGA/MAPK11/F2/RPL41/C8A/RPL8/PRKCG/RPL19/RPS10/PRKCB/RPS11/UBA52/RPS14/IRF3/RPS6/VWF/RPS17/TLR7/RPLP1/F13B/RPL11/RPL24/RPL10/RPL22/TMPRSS2/CGAS/C1QC/TLR8/RPL3L/FGB/RPL39/RPL37/RPS27/MAPK12/IFNA6/RPS12/RPL30/MAPK1/RPL13A/RPL15/RPS3/SELP/RPS24/RPL38/RPL14/IFNB1/C1S/RPL27/RPL34/RPL5/MAPK14/RPS8/RPL10L/IL2/RPS2/RPL4/TNFRSF1A/IFNA2/EGFR/RPS20/C1QA/PLCG2/RPS15A/MAPK3/RPL35/TRAF6/MAPK9/FGG/IFNA5/FAU/RPS7/IL12B/RPL29/RPS19/IKBKG/IKBKB/RPLP2/RPS29/RPL23A/C8B/F13A1/RPL35A/PLCG1/MBL2/RPS25/RPL3/RPL18/ACE/TYK2/PIK3R2/FCGR2A/IFNA1/IRAK1/IRAK4/RPL36AL/RPL36A/RPS21/C5AR1/ADAR/MAP3K7/IFNA14/RPL12/RSL24D1/C1QB/PRKCA/RPL26L1/C6/RPL17/C7/IFNA16/CHUK/MASP1/RPL36/RPL23/IFNA8/C1R/MAPK8/C8G/C9/TBK1/MAVS/RELA/RPS27L/MYD88/RPL31/STAT3/PIK3CB/NFKBIB/JAK1/RPL37A/C2/IKBKE/PIK3R3/IRF9/NRP1/EIF2AK2/PIK3R1/C3AR1/TAB2/STAT2/ADAM17/MAS1/C5/IFNAR1/TNF/PIK3CA/IL6ST/OAS2/PIK3CD/TLR3/TLR2/TRAF3/RPL27A/RPL22L1/CASP1/STAT1/IFNA21/IL6R/MAPK10/IL12A/MAPK13/ISG15/OAS3/TLR4/DDX58/OAS1/MX1/HBEGF/MX2/IFIH1/C3/NFKB1/IFNAR2/CCL2/AGTR1/CFD/JUN/CSF3/FOS/CXCL8/NFKBIA	195
KEGG	hsa00730	Thiamine metabolism	13/6848	15/8135	0.5685	0.6723	0.2881	ALPI/ALPG/ALPP/THTPA/AK8/ACP1/AK7/AK2/AK1/ALPL/TPK1/NTPCR/AK5	13
KEGG	hsa00062	Fatty acid elongation	23/6848	27/8135	0.5716	0.6723	0.2881	TECR/ECHS1/HACD3/ACOT4/HADHA/MECR/ELOVL4/PPT1/THEM5/ACAA2/HSD17B12/HADHB/ELOVL5/ELOVL1/THEM4/HADH/HACD2/ELOVL6/ACOT7/HACD4/HACD1/ELOVL3/ELOVL2	23
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	23/6848	27/8135	0.5716	0.6723	0.2881	BAAT/TECR/ACAA1/SCD5/HACD3/ACOT4/ELOVL4/HSD17B12/SCP2/ELOVL5/SCD/HSD17B4/ELOVL1/FADS1/HACD2/ACOX1/ELOVL6/ACOT7/HACD4/HACD1/ELOVL3/ELOVL2/FADS2	23
KEGG	hsa04657	IL-17 signaling pathway	79/6848	94/8135	0.5829	0.6831	0.2928	MUC5AC/IL17C/S100A9/IL17RC/MUC5B/MAPK11/IL17A/TAB3/ANAPC5/IL4/MAPK4/USP25/MAPK12/MAPK1/LCN2/IL17RE/ELAVL1/MAPK14/IL17B/MAPK3/TRAF6/MAPK9/IFNG/MAPK15/S100A7A/IKBKG/IKBKB/TRADD/IL17F/CCL17/S100A8/HSP90AA1/CASP8/HSP90AB1/S100A7/MAP3K7/DEFB4A/IL17RA/CHUK/IL13/MAPK8/TBK1/RELA/MAPK7/CASP3/TRAF2/IKBKE/GSK3B/JUND/IL25/TRAF5/FADD/MMP9/TAB2/TRAF4/IL17D/TRAF3IP2/TNF/MAPK6/TRAF3/HSP90B1/MAPK10/CEBPB/MAPK13/FOSL1/CCL11/NFKB1/CCL2/JUN/CCL20/CSF3/CXCL1/FOS/CXCL3/CXCL8/FOSB/CXCL2/NFKBIA/CXCL6	79
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	84/6848	100/8135	0.5858	0.6842	0.2932	IL37/CXCR3/CCL23/IL2RG/CCL15/XCL1/IL2RA/CCL25/CCL24/CCR2/TNFRSF10C/IL18RAP/CXCR5/CCR5/IL20/CXCL13/IL2/LTBR/TNFRSF1A/CCL21/IL10RA/CCR9/CCR3/CSF1R/CCL16/IL2RB/CXCR2/XCR1/PPBP/CCL17/CCR8/IL22RA1/IL34/CCL22/CX3CR1/CCR6/CCR4/CCL27/CCL19/CCL28/CSF1/IL19/CCL18/CXCL9/TNFRSF14/IL10/CXCR1/TNFRSF10B/CCL1/TNFSF14/CCR10/CCR7/IL18/PF4/CXCR4/TNF/PF4V1/IL6ST/IL20RA/CCL26/CCR1/IL10RB/IL6R/CXCL12/IL24/IL18R1/CCL13/IL20RB/CXCL14/CCL4/CCL11/ACKR3/CCL2/CCL20/CX3CL1/TNFRSF1B/TNFSF10/CXCL1/CXCL3/CXCL8/CXCL2/CCL5/ACKR4/CXCL6	84
KEGG	hsa04658	Th1 and Th2 cell differentiation	77/6848	92/8135	0.6183	0.7196	0.3084	HLA-DQB1/HLA-DOA/JAK3/IL12RB1/NOTCH3/MAPK11/HLA-DQA1/PPP3CB/IL2RG/DLL1/IL2RA/IL4/PPP3R2/CD3E/ZAP70/MAPK12/MAPK1/STAT6/RUNX3/MAPK14/IL2/CD3G/MAPK3/DLL3/MAPK9/IFNG/IL12B/IKBKG/IKBKB/GATA3/IL2RB/CD4/PLCG1/LCK/TBX21/CD3D/PRKCQ/TYK2/NFATC2/RBPJL/MAML3/STAT5B/JAG2/CHUK/IL13/MAPK8/RELA/LAT/NOTCH2/NOTCH1/NFKBIB/JAK1/PPP3CA/IL12RB2/NFATC3/HLA-DPA1/IFNGR1/MAF/MAML2/STAT1/CD247/MAPK10/IL12A/HLA-DRA/MAPK13/JAK2/IL4R/JAG1/IFNGR2/NFATC1/NFKB1/PPP3R1/JUN/NFKBIE/STAT4/FOS/NFKBIA	77
KEGG	hsa00500	Starch and sucrose metabolism	30/6848	36/8135	0.6601	0.7655	0.3281	HKDC1/GBA3/SI/ENPP3/GANC/GYS2/HK3/TREH/G6PC2/G6PC/GBE1/G6PC3/GPI/GYG1/PYGB/PGM1/HK1/GAA/PYGM/GYS1/ENPP1/UGP2/GYG2/PYGL/AGL/PGM2/HK2/MGAM/AMY2B/PGM2L1	30
KEGG	hsa01240	Biosynthesis of cofactors	127/6848	153/8135	0.7023	0.8117	0.3479	ALPI/ALPG/ALAS2/IDO2/ALPP/SDR16C5/AK8/MAT1A/COQ7/VKORC1/NADK/COX15/HAAO/DLD/FECH/ASPDH/HPD/SPR/NMNAT3/NADSYN1/MOCS1/UGT2B17/RDH12/FPGS/VKORC1L1/RDH13/RFK/UGT1A6/ALAD/PPOX/GGCX/CMPK1/COQ5/GSS/COASY/GPHN/UGT2A3/AK7/ADSL/UGT2B15/NME7/PPCS/COX10/AFMID/AKR1A1/UGT1A8/AK3/PANK2/PPCDC/SHMT1/MPI/FLAD1/GUSB/UROD/PANK3/NME3/MOCS2/COQ6/MTHFD1L/MMAB/CAD/PMM2/TDO2/LIPT1/MAT2A/AK2/PTS/NME4/BCO1/PMM1/BCAT2/NMNAT1/MTHFD1/NMNAT2/AK1/COQ2/PNPO/NADK2/UROS/UMPS/COQ3/DHFR2/ALAS1/AK9/ALPL/TPK1/DHODH/PDXK/PANK1/SHMT2/NAPRT/CPOX/GMPPA/UGP2/UGDH/PDXP/NQO1/GCLM/HMBS/MTHFD2L/CTPS2/GCLC/CTPS1/OXSM/GGH/MTHFD2/BCAT1/NME6/ALDH2/ALDH3A2/ALDH1B1/PHOSPHO2/NME1/GMPPB/RGN/PSAT1/QPRT/DHFR/CMPK2/AK5/LIAS/KMO/DHRS3/HSD17B6/KYNU/RDH11/IDO1	127
KEGG	hsa04913	Ovarian steroidogenesis	42/6848	51/8135	0.7193	0.8273	0.3546	ALOX5/PRKACB/FSHR/GNAS/LHCGR/INS/PRKACA/PLA2G4F/HSD3B2/HSD3B1/CYP17A1/CYP19A1/FSHB/ADCY2/ADCY1/ACOT4/CYP2J2/SCARB1/ADCY9/HSD17B1/ADCY5/BMP15/STAR/PRKACG/ADCY3/CGA/ADCY6/ADCY7/CYP1A1/PLA2G4C/CYP11A1/HSD17B2/IGF1R/ADCY8/INSR/LDLR/AKR1C3/ADCY4/BMP6/CYP1B1/IGF1/PLA2G4A	42
KEGG	hsa00120	Primary bile acid biosynthesis	14/6848	17/8135	0.7233	0.8273	0.3546	BAAT/ACOT8/AKR1D1/SLC27A5/AKR1C4/SCP2/CYP46A1/HSD17B4/HSD3B7/ACOX2/CYP27A1/CYP39A1/CYP8B1/CYP7A1	14
KEGG	hsa00450	Selenocompound metabolism	14/6848	17/8135	0.7233	0.8273	0.3546	TXNRD2/SCLY/SEPHS1/KYAT1/SEPHS2/PAPSS1/PSTK/KYAT3/SEPSECS/MTR/TXNRD1/CTH/MARS2/PAPSS2	14
KEGG	hsa04742	Taste transduction	70/6848	86/8135	0.8076	0.9206	0.3946	P2RX2/PLCB2/GABRA5/GRM1/PDE1B/SCNN1G/P2RY1/GABRA1/ENTPD2/GABRA6/SCN9A/SCNN1A/GABRA4/PRKACB/HCN4/GABRA2/PRKACA/HTR1A/TRPM5/HTR1D/GRM4/GNAT3/HTR3A/P2RY4/GNG13/P2RX3/HTR3C/GABRA3/CHRM3/TAS2R14/TAS2R7/HTR1F/SCNN1B/HTR3B/TAS2R13/TAS2R10/HTR1E/GABBR2/ASIC2/PLCB3/TAS2R5/TAS2R1/TAS2R9/TAS1R1/TAS2R40/TAS2R3/TAS2R45/KCNK5/HTR1B/CALHM1/TAS2R4/PKD2L1/PRKACG/TAS1R2/TAS2R50/TAS2R38/ADCY6/TAS2R39/GABBR1/CACNA1A/ITPR3/CACNA1C/SCN2A/PLCB1/PDE1C/ADCY8/ADCY4/PLCB4/PDE1A/SCN3A	70
KEGG	hsa04623	Cytosolic DNA-sensing pathway	51/6848	63/8135	0.8127	0.9233	0.3957	ZBP1/IRF3/CGAS/IFNA6/IFNB1/IFNA2/IFNA5/IKBKG/IKBKB/POLR2E/POLR3C/IFNA1/POLR2F/ADAR/IFNA14/POLR2L/POLR3G/POLR3F/IFNA16/CHUK/IFNA8/POLR2H/TBK1/MAVS/RELA/POLR1D/RIPK1/NFKBIB/POLR3B/POLR3A/IKBKE/TREX1/POLR2K/IL18/POLR3E/POLR3D/POLR3H/POLR3GL/POLR1C/RIPK3/PYCARD/CASP1/IFNA21/IRF7/POLR3K/DDX58/AIM2/CCL4/NFKB1/CCL5/NFKBIA	51
KEGG	hsa00591	Linoleic acid metabolism	23/6848	29/8135	0.8369	0.9475	0.4061	CYP1A2/CYP2C9/PLA2G12B/PLA2G2D/CYP2C8/CYP2C19/PLA2G10/PLA2G4F/CYP3A4/PLA2G2F/PLA2G6/PLA2G3/PLB1/CYP2J2/ALOX15/PLA2G1B/CYP2E1/PLA2G12A/PLA2G4C/PLA2G5/PLAAT3/PLA2G2A/PLA2G4A	23
KEGG	hsa04976	Bile secretion	72/6848	89/8135	0.8414	0.9495	0.407	AQP4/SLCO1A2/CFTR/BAAT/SLC22A8/SLC4A5/SULT2A1/ATP1A4/ABCB11/SLC4A2/SCTR/KCNN2/SLC22A7/PRKACB/FXYD2/SLC5A1/GNAS/SLC51B/SLC10A1/ATP1A2/NR1H4/ATP1B4/PRKACA/ATP1B2/SLCO1B3/SLC51A/CYP3A4/SLC9A3/AQP8/SLC27A5/ATP1A1/ABCB1/ADCY2/UGT2B17/ADCY1/ATP1B3/SCT/SCARB1/ABCG8/CA2/RXRA/ADCY9/ATP1A3/UGT1A6/EPHX1/SLC9A1/ADCY5/UGT2A3/UGT2B15/PRKACG/ADCY3/UGT1A8/ADCY6/SLCO1B1/SLC22A1/ADCY7/SLC4A4/SLC10A2/ABCB4/ABCC4/ABCG2/ABCC2/ABCC3/ADCY8/HMGCR/LDLR/ADCY4/CYP7A1/AQP9/NCEH1/ATP1B1/SLC2A1	72
KEGG	hsa05140	Leishmaniasis	62/6848	77/8135	0.8509	0.9569	0.4102	CR1/HLA-DQB1/CYBB/HLA-DOA/MAPK11/HLA-DQA1/PRKCB/EEF1A1/IL4/NOS2/NCF4/MAPK12/MAPK1/ITGB1/MAPK14/MAPK3/TRAF6/IFNG/TAB1/IL12B/ELK1/FCGR2A/PTPN6/EEF1A2/IRAK1/TGFB1/IRAK4/MAP3K7/ITGAM/FCGR3B/NCF1/CR1L/FCGR2C/TGFB3/RELA/MYD88/IL10/NFKBIB/JAK1/CYBA/TAB2/HLA-DPA1/IFNGR1/TNF/NCF2/TLR2/ITGA4/STAT1/MARCKSL1/IL12A/HLA-DRA/MAPK13/JAK2/TLR4/IFNGR2/ITGB2/TGFB2/C3/NFKB1/JUN/FOS/NFKBIA	62
KEGG	hsa05321	Inflammatory bowel disease	52/6848	65/8135	0.8628	0.9671	0.4145	IL22/RORC/HLA-DQB1/HLA-DOA/IL12RB1/IL23R/HLA-DQA1/IL2RG/IL17A/FOXP3/SMAD2/IL4/IL18RAP/STAT6/IL2/IL21/IFNG/IL12B/GATA3/IL17F/TBX21/IL21R/TGFB1/TGFB3/IL13/RELA/SMAD3/STAT3/IL10/TLR5/IL12RB2/IL18/HLA-DPA1/IFNGR1/MAF/TNF/TLR2/STAT1/IL12A/HLA-DRA/IL4R/TLR4/NOD2/IL23A/IL18R1/IFNGR2/TGFB2/RORA/NFATC1/NFKB1/JUN/STAT4	52
KEGG	hsa05202	Transcriptional misregulation in cancer	156/6848	193/8135	0.9152	1	0.4286	MYCN/PAX3/PTCRA/BAIAP3/ETV4/CD86/PTK2/POLK/ELK4/MPO/ZBTB17/TLX1/BCL11B/WNT16/ATF1/TMPRSS2/TP53/RARA/SSX1/SPINT1/MLLT1/PAX7/TFE3/BCL2L1/RXRB/DEFA5/CEBPE/IL1R2/SLC45A3/PROM1/ASPSCR1/SPI1/DEFA4/LYL1/RUNX1/PAX5/MAX/SP1/RXRG/ZBTB16/FEV/TCF3/CSF1R/IL2RB/SUPT3H/NCOR1/NTRK1/AFF1/TGFBR2/ITGB7/RXRA/GZMB/DEFA6/CCNT2/ITGAM/FLI1/FLT3/PAX8/PRCC/PML/SS18/DOT1L/HPGD/MEN1/WT1/ATM/KMT2A/RELA/HDAC1/BMI1/MDM2/CDK9/MLF1/SIX4/ETV5/MEF2C/FUS/DDX5/NSD2/ZEB1/ELANE/ETV6/KDM6A/CDK14/CDKN1A/HDAC2/ETV1/CCNT1/HHEX/TAF15/JMJD1C/BIRC2/BAX/ETV7/HMGA2/LDB1/PER2/MMP9/EWSR1/SS18L1/BMP2K/MET/MYC/BAK1/MAF/PBX1/PLAU/CCND2/NUPR1/IGFBP3/IGF1R/KLF3/HOXA11/EYA1/GRIA3/SMAD1/CCNA2/FLT1/CD40/GADD45G/DDIT3/SIN3A/CCNA1/ERG/FOXO1/CDKN2C/FUT8/CEBPB/JUP/PBX3/CEBPA/PPARG/SIX1/MLLT3/DUSP6/RUNX1T1/LMO2/BCL6/DDB2/ID2/CDKN1B/GADD45A/PLAT/CD14/MITF/NR4A3/HOXA9/PDGFA/ARNT2/NFKB1/TRAF1/MEIS1/IGF1/GADD45B/CXCL8/NFKBIZ	156
KEGG	hsa05416	Viral myocarditis	47/6848	60/8135	0.918	1	0.4286	MYH6/ITGAL/HLA-DQB1/HLA-DOA/SGCB/CD86/HLA-DQA1/PRF1/CD28/CD80/EIF4G2/EIF4G3/CXADR/RAC3/CD40LG/RAC1/CASP8/ACTB/DAG1/CASP9/HLA-G/MYH7/CASP3/ACTG1/HLA-DPA1/HLA-F/RAC2/CD55/SGCA/CAV1/ABL1/CYCS/SGCD/FYN/HLA-E/CD40/LAMA1/DMD/HLA-DRA/ABL2/CCND1/EIF4G1/ITGB2/LAMA2/SGCG/BID/ICAM1	47
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	171/6848	212/8135	0.9325	1	0.4286	ADRB3/ESR1/CHRNA3/ATF2/AIPL1/CACNA1B/TNFSF11/CACNA1D/PRKCG/ADRB1/ARRB2/PRKCB/CYP1A2/ESR2/DLL1/FGF17/PRKACB/NR1I3/GNAS/CHRNA4/RPS6KB1/BCL2/PRKACA/CREB3L3/MAPK1/CHRNB2/CYP3A4/AKT2/RXRB/CHRNB4/EPHX3/KRAS/CREB1/BAD/KPNA6/EGFR/ARNT/EGF/GNAI3/MAPK3/DLL3/SRC/RB1/EPHX4/WNT1/FGF3/RAF1/CACNA1S/FGF6/RXRG/FGF20/AKT1/PTGES3/FGF16/ADCY2/UGT2B17/E2F1/ADCY1/GSTA1/RPS6KB2/PIK3R2/FGF4/RXRA/ATF6B/ADCY9/UGT1A6/EPHX1/HSP90AA1/FGF8/HSP90AB1/GRB2/ADCY5/UGT2A3/AKT3/UGT2B15/CACNA1F/GNAI2/MAP2K2/PRKCA/PRKACG/ADCY3/UGT1A8/CREB3L1/STAT5B/CYP2B6/GSTA3/GSTM4/FGF22/RPS6KA6/CREB3/RPS6KA1/XIAP/ADCY6/MGST3/RELA/PGR/CCND3/NOTCH2/STAT3/PIK3CB/AIP/PAQR7/SOS2/AR/KPNA5/ADCY7/CACNA1A/GSTO2/CYP1A1/GSTM1/KPNA4/IKBKE/PPARA/HRAS/RPS6KA2/PIK3R3/KPNA1/CACNA1C/PAQR8/SOS1/NRAS/ARRB1/PIK3R1/ATF4/GSTA4/MGST1/CREB3L4/KPNA3/MAP2K1/GSTO1/KPNB1/CDC25A/ADRB2/MTOR/CREB3L2/MYC/KLF4/PIK3CA/KPNA2/ADCY8/PIK3CD/VEGFA/BIRC5/FGF7/HSP90B1/EPHX2/EIF4EBP1/VDR/RPS6KA3/GNAI1/JAK2/CREB5/JAG1/ADCY4/CCND1/PAQR5/MGST2/BCL6/FGF5/GSTM3/GSTM5/CDC6/AHR/FGF2/NFKB1/CYP1B1/FGF18/FGF9/JUN/FOS/FGF10	171
KEGG	hsa04640	Hematopoietic cell lineage	78/6848	99/8135	0.9426	1	0.4286	CR1/CSF2RA/IL5RA/EPOR/THPO/CD22/MS4A1/HLA-DQB1/HLA-DOA/CSF3R/FCER2/CD1E/EPO/HLA-DQA1/CD8B/IL2RA/CD5/IL4/CR2/ITGA2B/CD3E/CD1C/CD2/IL9R/CD33/CD37/IL1R2/CD3G/CD8A/DNTT/CD19/CSF1R/CD1A/CD4/IL3RA/TFRC/CD3D/GP9/IL1R1/ITGB3/CD59/CD1B/GP5/ITGA5/ITGAM/FLT3/CR1L/GP1BB/CSF1/KITLG/GP1BA/FLT3LG/CD7/CD1D/ITGA3/CD44/CD24/HLA-DPA1/CD55/TNF/IL11RA/CD38/ITGA4/ANPEP/IL6R/ITGA1/IL11/HLA-DRA/CD34/IL4R/ITGA6/CD14/ITGA2/IL7/MME/CSF3/CD36/IL7R	78
KEGG	hsa05323	Rheumatoid arthritis	73/6848	93/8135	0.9462	1	0.4286	ITGAL/HLA-DQB1/CTLA4/HLA-DOA/ATP6V1C2/CD86/TNFSF11/HLA-DQA1/ATP6V0C/IL17A/ATP6V0A1/ATP6V1F/ATP6V0D2/CD28/CD80/ATP6V0E1/ATP6V1B1/ATP6V0D1/ATP6V0A4/PTH/ATP6V1G3/IFNG/ATP6V1D/LTB/ATP6V1E1/ATP6AP1/TGFB1/TCIRG1/CTSK/ATP6V1G2/ATP6V1E2/TGFB3/TNFRSF11A/CSF1/ATP6V1C1/ACP5/ATP6V1A/ATP6V1G1/ATP6V1H/ATP6V1B2/TNFSF13/IL18/CTSL/ATP6V0B/ATP6V0A2/TEK/HLA-DPA1/TNF/ATP6V0E2/ANGPT1/TLR2/VEGFA/FLT1/CXCL12/IL11/HLA-DRA/TLR4/IL23A/TNFSF13B/ITGB2/TGFB2/CCL2/JUN/CCL20/CXCL1/FOS/CXCL3/CXCL8/CXCL2/CCL5/IL15/CXCL6/ICAM1	73
KEGG	hsa00592	alpha-Linolenic acid metabolism	18/6848	25/8135	0.9662	1	0.4286	PLA2G12B/PLA2G2D/PLA2G10/PLA2G4F/PLA2G2F/ACAA1/PLA2G6/PLA2G3/PLB1/PLA2G1B/PLA2G12A/PLA2G4C/PLA2G5/ACOX1/PLAAT3/FADS2/PLA2G2A/PLA2G4A	18
KEGG	hsa04672	Intestinal immune network for IgA production	36/6848	49/8135	0.9832	1	0.4286	HLA-DQB1/HLA-DOA/CD86/HLA-DQA1/PIGR/CCL25/IL4/CD28/CD80/TNFRSF13B/MADCAM1/TNFRSF17/AICDA/IL2/LTBR/CD40LG/CCR9/ITGB7/TGFB1/ICOSLG/TNFRSF13C/CCL28/ICOS/IL10/CCR10/TNFSF13/CXCR4/HLA-DPA1/MAP3K14/ITGA4/CXCL12/CD40/HLA-DRA/TNFSF13B/IL15RA/IL15	36
KEGG	hsa05168	Herpes simplex virus 1 infection	398/6848	495/8135	0.9914	1	0.4286	SYK/PTPN11/HLA-DQB1/ZNF674/HLA-DOA/ZNF41/ZNF81/ZNF175/ZNF169/ZNF425/ZNF780B/FASLG/HLA-DQA1/ZNF577/B2M/ZNF333/ZNF354C/NECTIN1/ZNF527/IRF3/ZNF829/HCFC1/CGAS/TP53/TSC2/BCL2/IFNA6/ZNF157/ZNF614/RBAK/ZNF549/ZNF544/AKT2/ZNF814/BCL2L1/ZIK1/IFNB1/EIF2B1/BAD/CFP/ZNF226/TNFRSF1A/ZNF599/IFNA2/NXF3/ZNF709/ZNF540/ZNF529/ZNF718/ZNF568/ZNF114/PILRA/SRC/ZNF778/TRAF6/PPP1CC/RHEB/IFNG/ZNF471/ZNF418/IFNA5/TAB1/IL12B/ZNF90/EIF2B5/ZNF461/ZNF317/AKT1/ZNF688/IKBKG/IKBKB/ZNF233/ZNF875/ZNF582/ZNF768/ZNF282/ZNF257/TRADD/ZNF621/ZNF99/ZIM3/ZNF808/ZNF707/ZNF154/ZNF853/ZNF556/ZNF746/ZNF208/ZNF777/ZNF19/HCFC2/ZNF519/POU2F3/ZNF235/ZNF836/ZFP28/ZNF273/TYK2/PIK3R2/PPP1CB/ZNF44/ZNF605/ZNF611/ITGB3/ZNF675/ZNF101/ZNF783/EIF2B4/ZNF563/ZNF765/ZNF749/ZNF486/ZSCAN32/IFNA1/IRAK1/ZNF3/ZNF229/ZNF736/IRAK4/CASP8/ZNF671/ZNF205/CARD9/NECTIN2/CD74/ZNF221/ZNF343/MAP3K7/ITGA5/IFNA14/ZNF551/ZNF555/ZNF677/AKT3/ZNF473/EIF2AK1/ZNF641/ZNF214/PPP1CA/ZNF33A/ZNF254/ZNF300/PML/ZNF480/ZNF8/ZNF211/POU2F1/ZNF398/ZNF554/ZNF792/ZNF721/ZNF382/ZNF286A/ZNF141/ZNF337/ZNF14/ZNF426/EIF2B2/ZNF430/ZNF334/ZNF506/ZNF107/ZNF570/IFNA16/CHUK/ZNF615/ZNF701/ZNF470/ZNF12/CASP9/NXF1/ZNF283/ZNF805/ZNF585B/IFNA8/HLA-G/ZNF619/ZNF585A/ZNF764/ZNF793/ZFP69/ZNF528/ZNF93/ZNF530/ZNF268/ZNF682/ZNF547/ZNF442/ZNF589/ZNF25/TBK1/ZNF383/MAVS/ZNF7/ZNF155/ZNF189/RELA/ZNF77/ZNF607/ZNF275/ZNF256/ZNF160/ZNF224/MYD88/ZNF200/ZNF510/ZFP57/TSC1/TNFRSF14/ZNF227/ZNF234/ZNF460/ZNF45/PIK3CB/ZNF222/EIF2B3/ZNF225/ZNF552/ZNF780A/CASP3/ZNF10/ZNF600/JAK1/APAF1/ZNF79/ZNF567/CALR/ZNF34/ZNF569/ZNF700/ZFP14/SRPK1/ZNF565/TNFSF14/ZNF354B/ZNF304/ZNF85/ZNF347/ZNF649/ZNF573/ZNF441/TRAF2/IKBKE/ZNF561/ZNF74/ZNF548/ZNF182/ZNF440/ZNF17/ZNF583/ZNF26/ZNF320/ZNF132/ZNF212/ZNF669/RNASEL/ZNF136/PIK3R3/IRF9/EIF2S1/ZNF662/SP100/ZNF786/PDIA3/ZFP69B/ZNF133/ZNF492/ZNF708/ZNF250/ZNF180/ZNF23/ZNF627/EIF2AK2/ZNF490/ZNF350/PIK3R1/ZNF311/ZNF606/ZNF559/ZNF20/ZNF557/ZNF416/ZNF140/ZNF597/ZNF253/TRAF5/ZNF439/ZNF550/ZNF2/ZNF846/ZFP1/ZNF684/ZNF91/POU2F2/BIRC2/ZNF124/BAX/FADD/DAXX/ZNF560/ZNF100/TAB2/ZNF689/ZNF30/ZNF230/ZNF83/ZNF195/HLA-DPA1/MTOR/HLA-F/ZNF717/ZNF782/ZNF57/ZNF680/ZNF248/ZNF284/STAT2/ZNF415/ZNF184/ZNF285/ZNF624/ZFP90/ZNF468/IFNGR1/BAK1/ZNF630/C5/ZNF766/ZNF112/IFNAR1/ZNF419/TNF/PIK3CA/ZNF223/ZNF135/OAS2/ZNF667/ZNF616/EIF2AK3/ZNF562/ZFP30/EIF2AK4/ZNF33B/ZNF43/ZNF331/ZNF302/PIK3CD/CYCS/ZNF177/FAS/TLR3/TICAM1/TLR2/TRAF3/HLA-E/ZNF879/STAT1/ZFP37/IFNA21/ZNF596/ZNF514/ZNF823/EIF4EBP1/ZNF37A/ZNF251/ZNF791/ZNF713/IL12A/IRF7/HLA-DRA/TAP1/JAK2/ZNF571/OAS3/SOCS3/BST2/DDX58/ZNF610/ZNF785/OAS1/IFNGR2/ZNF436/ZNF404/TAP2/ZNF566/ZNF587/ALYREF/IFIH1/ZNF420/C3/ZNF267/ZNF670/NFKB1/IFNAR2/CCL2/BID/CCL5/NFKBIA	398
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	100/6848	131/8135	0.9934	1	0.4286	SYK/PTPN11/ITGAL/NCR1/KLRD1/FASLG/PPP3CB/PRKCG/PRKCB/CD48/PRF1/PPP3R2/SH2D1B/PTK2B/HCST/NCR3/KLRC3/ZAP70/TYROBP/ARAF/IFNA6/MAPK1/NCR2/CD244/IFNB1/RAC3/KLRK1/KRAS/SH2D1A/IFNA2/PLCG2/KIR3DL1/MAPK3/IFNG/VAV2/IFNA5/RAF1/ULBP1/VAV1/SH3BP2/PLCG1/LCK/RAC1/SHC1/PIK3R2/NFATC2/GZMB/PTPN6/IFNA1/GRB2/IFNA14/FCGR3B/BRAF/SHC4/MAP2K2/ULBP3/PRKCA/FCER1G/IFNA16/SHC3/RAET1E/IFNA8/HLA-G/KIR3DL2/LAT/PIK3CB/TNFRSF10B/CASP3/SOS2/PPP3CA/HRAS/PAK1/PIK3R3/VAV3/SOS1/NRAS/PIK3R1/MAP2K1/RAC2/IFNGR1/SHC2/IFNAR1/TNF/PIK3CA/PIK3CD/FAS/FYN/HLA-E/CD247/IFNA21/ULBP2/ICAM2/IFNGR2/ITGB2/NFATC1/PPP3R1/IFNAR2/BID/TNFSF10/ICAM1	100
KEGG	hsa03040	Spliceosome	111/6848	147/8135	0.9979	1	0.4286	WBP11/SF3A1/SNW1/AQR/DDX42/SNRNP27/DHX38/SF3B4/PRPF31/SF3B5/HSPA6/PRPF8/CCDC12/SF3B1/USP39/CDC40/RBM22/U2SURP/CWC15/PPIE/HNRNPC/LSM8/DHX8/HNRNPU/THOC1/ZMAT2/HNRNPA1/CDC5L/SNRNP200/PRPF6/PQBP1/SMNDC1/SF3A2/PRPF38A/XAB2/SF3A3/PRPF40A/BCAS2/SNRPD2/SNRNP70/SNRPC/PPIH/U2AF2/SNRPE/SF3B6/SART1/ISY1/CHERP/PRPF40B/HNRNPK/LSM3/DDX46/EIF4A3/SF3B3/HNRNPM/EFTUD2/SNRPB2/PRPF3/SNU13/PRPF18/DHX15/BUD31/PRPF19/RBMX/SYF2/CRNKL1/SNRPD3/DDX23/NCBP2/PLRG1/NCBP1/CTNNBL1/MAGOH/ACIN1/THOC2/PRPF38B/TRA2B/LSM7/PUF60/U2AF1L4/LSM5/U2AF1/RBM17/FUS/SNRPB/DDX5/TCERG1/TXNL4A/PRPF4/RBM8A/HSPA1A/LSM4/SNRPG/TRA2A/LSM6/SNRPA/HNRNPA3/PHF5A/LSM2/SNRPF/RP9/SLU7/RBM25/SNRPD1/HSPA1L/MAGOHB/PPIL1/SNRPA1/SNRNP40/HSPA2/ALYREF	111
KEGG	hsa00830	Retinol metabolism	48/6848	68/8135	0.9986	1	0.4286	CYP2A6/ADH6/CYP1A2/CYP2C9/ADH7/DHRS9/CYP2C8/CYP2C18/SDR16C5/CYP3A4/RPE65/CYP2S1/CYP26A1/CYP3A7/CYP2W1/CYP3A5/DGAT1/ADH1A/ADH4/RDH16/RDH8/UGT2B17/RDH12/RDH13/UGT1A6/UGT2A3/UGT2B15/UGT1A8/CYP2B6/RETSAT/PNPLA4/BCO1/CYP2A7/ADH5/CYP1A1/AOX1/RDH5/CYP26B1/ADH1C/ALDH1A3/ALDH1A2/DHRS3/CYP27C1/ADH1B/RDH10/HSD17B6/ALDH1A1/RDH11	48
KEGG	hsa00140	Steroid hormone biosynthesis	42/6848	61/8135	0.9992	1	0.4286	SULT1E1/COMT/SRD5A2/CYP1A2/SULT2B1/CYP3A4/AKR1D1/HSD3B2/CYP3A7/HSD3B1/CYP17A1/CYP11B1/CYP3A5/CYP19A1/UGT2B17/HSD11B1L/HSD11B2/UGT1A6/AKR1C4/HSD17B1/HSD17B12/LRTOMT/UGT2A3/HSD17B3/UGT2B15/UGT1A8/CYP11B2/STS/CYP2E1/DHRS11/CYP1A1/CYP11A1/SRD5A3/HSD17B2/HSD17B8/SRD5A1/AKR1C3/AKR1C1/AKR1C2/CYP7A1/HSD17B6/CYP1B1	42
KEGG	hsa04940	Type I diabetes mellitus	28/6848	43/8135	0.9995	1	0.4286	HLA-DQB1/HLA-DOA/CD86/FASLG/HLA-DQA1/GAD2/GAD1/PRF1/CD28/CD80/INS/IL2/IFNG/IL12B/GZMB/PTPRN/ICA1/HLA-G/HSPD1/PTPRN2/HLA-DPA1/HLA-F/TNF/FAS/HLA-E/IL12A/HLA-DRA/CPE	28
KEGG	hsa05310	Asthma	19/6848	31/8135	0.9995	1	0.4286	HLA-DQB1/HLA-DOA/HLA-DQA1/FCER1A/IL4/PRG2/MS4A2/CD40LG/IL9/RNASE3/FCER1G/EPX/IL13/IL10/HLA-DPA1/TNF/CD40/HLA-DRA/CCL11	19
KEGG	hsa05203	Viral carcinogenesis	154/6848	204/8135	0.9996	1	0.4286	SCIN/SYK/VAC14/HDAC3/ATF2/JAK3/SNW1/HDAC6/HDAC8/ATP6V0D2/IRF3/PRKACB/YWHAE/DDX3X/TP53/GTF2A2/PRKACA/GTF2A1/CREB3L3/MAPK1/ATP6V0D1/CCR5/YWHAQ/KRAS/CREB1/BAD/GTF2H1/LTBR/CDKN2A/VDAC3/MAPK3/SRC/RB1/CCR3/HDAC10/HDAC11/IKBKG/TBP/SND1/TRADD/GTF2A1L/PSMC1/USP7/RAC1/RHOA/UBR4/PIK3R2/CCR8/HPN/RBL1/ATF6B/HNRNPK/CDK2/MAPKAPK2/PKM/CASP8/GRB2/RBPJL/DDB1/CCR4/HDAC7/ACTN4/GTF2E2/PRKACG/CREB3L1/STAT5B/CDK4/HDAC4/MAD1L1/YWHAG/HLA-G/DLG1/KAT2A/CREB3/YWHAB/CREBBP/GSN/DNAJA3/GTF2H3/SCRIB/RELA/CCND3/HDAC1/MDM2/TBPL1/STAT3/MRPS18B/PIK3CB/RANBP1/CASP3/SRF/JAK1/GTF2H4/PXN/TRAF2/HRAS/RBL2/PIK3R3/IRF9/SP100/NRAS/EIF2AK2/CDKN1A/GTF2B/PIK3R1/EP300/UBE3A/SKP2/POLB/ATF4/HDAC2/TRAF5/CREB3L4/BAX/CHD4/HLA-F/CDC42/YWHAH/CREB3L2/NFKB2/BAK1/HDAC5/CCND2/PIK3CA/IL6ST/CCNE1/PIK3CD/HDAC9/TRAF3/HLA-E/CCNA2/GTF2E1/ACTN1/CDC20/CDK1/CCNA1/IRF7/CDK6/CDKN2B/KAT2B/CREB5/CCNE2/CCND1/RASA2/CDKN1B/C3/NFKB1/TRAF1/JUN/LYN/PMAIP1/EGR3/EGR2/NFKBIA	154
KEGG	hsa00983	Drug metabolism - other enzymes	56/6848	80/8135	0.9996	1	0.4286	UPB1/CYP2A6/UPP2/MPO/UCK1/CYP3A4/UCKL1/UGT2B17/GSTA1/GSTP1/NAT2/UGT1A6/GMPS/CMPK1/UGT2A3/UGT2B15/XDH/NME7/UGT1A8/GSTA3/GSTM4/GUSB/CYP2E1/TK2/NME3/MGST3/CES2/DUT/NME4/CYP2A7/NAT1/GSTO2/GSTM1/IMPDH2/ITPA/UMPS/DPYD/GSTA4/MGST1/GSTO1/IMPDH1/TPMT/DPYS/TK1/HPRT1/CDA/RRM2B/NME6/UPP1/UCK2/NME1/TYMP/MGST2/RRM2/GSTM3/GSTM5	56
KEGG	hsa05330	Allograft rejection	24/6848	38/8135	0.9996	1	0.4286	HLA-DQB1/HLA-DOA/CD86/FASLG/HLA-DQA1/PRF1/IL4/CD28/CD80/IL2/IFNG/CD40LG/IL12B/GZMB/HLA-G/IL10/HLA-DPA1/HLA-F/TNF/FAS/HLA-E/CD40/IL12A/HLA-DRA	24
KEGG	hsa05150	Staphylococcus aureus infection	68/6848	96/8135	0.9997	1	0.4286	FCAR/ITGAL/HLA-DQB1/HLA-DOA/MASP2/HLA-DQA1/KRT40/FPR2/KRT25/FPR3/C1QC/DEFB1/PLG/FPR1/PTAFR/CAMP/SELP/C1S/DEFA5/FCGR2B/KRT13/C1QA/DEFA4/FGG/KRT24/SELPLG/KRT23/DSG1/KRT20/MBL2/KRT37/FCGR2A/KRT12/KRT17/KRT32/KRT9/DEFA6/C5AR1/ITGAM/KRT35/FCGR3B/DEFB4A/C1QB/FCGR2C/MASP1/KRT33B/C1R/KRT15/KRT31/KRT16/KRT14/KRT10/IL10/KRT36/C2/KRT27/CFH/C3AR1/HLA-DPA1/C5/HLA-DRA/KRT18/ITGB2/C3/CFD/KRT19/CFI/ICAM1	68
KEGG	hsa00982	Drug metabolism - cytochrome P450	49/6848	72/8135	0.9998	1	0.4286	CYP2A6/ADH6/CYP1A2/ALDH3B2/CYP2C9/ADH7/CYP2C8/CYP2C19/CYP3A4/ALDH3A1/CYP3A5/ADH1A/ADH4/UGT2B17/GSTA1/GSTP1/UGT1A6/UGT2A3/UGT2B15/HPGDS/FMO5/UGT1A8/CYP2B6/GSTA3/GSTM4/CYP2E1/MGST3/CYP2A7/ALDH3B1/ADH5/GSTO2/GSTM1/CYP2D6/GSTK1/GSTA4/MGST1/GSTO1/MAOA/AOX1/MAOB/MGST2/ADH1C/GSTM3/GSTM5/FMO3/ADH1B/FMO4/FMO2/FMO1	49
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	53/6848	78/8135	0.9999	1	0.4286	CYP2A6/SULT2A1/ADH6/CYP1A2/ALDH3B2/CYP2C9/ADH7/CYP3A4/ALDH3A1/CYP2S1/CYP3A5/ADH1A/ADH4/DHDH/CYP2A13/UGT2B17/GSTA1/HSD11B1L/CYP2F1/GSTP1/UGT1A6/EPHX1/UGT2A3/UGT2B15/HPGDS/UGT1A8/CYP2B6/GSTA3/GSTM4/CYP2E1/AKR7A3/MGST3/CBR1/CYP2A7/ALDH3B1/ADH5/GSTO2/CYP1A1/GSTM1/CYP2D6/GSTK1/AKR7A2/GSTA4/MGST1/GSTO1/AKR1C1/MGST2/ADH1C/GSTM3/GSTM5/ADH1B/CYP1B1/CBR3	53
KEGG	hsa05320	Autoimmune thyroid disease	34/6848	53/8135	0.9999	1	0.4286	HLA-DQB1/CTLA4/HLA-DOA/CD86/FASLG/HLA-DQA1/TG/PRF1/IL4/TSHB/CD28/CD80/IFNA6/TSHR/IL2/IFNA2/IFNA5/CD40LG/GZMB/IFNA1/IFNA14/TPO/IFNA16/CGA/IFNA8/HLA-G/IL10/HLA-DPA1/HLA-F/FAS/HLA-E/IFNA21/CD40/HLA-DRA	34
KEGG	hsa04217	Necroptosis	115/6848	159/8135	1	1	0.4286	NLRP3/ZBP1/CYBB/JAK3/FASLG/CAMK2B/SLC25A31/HMGB1/PPIA/BCL2/IFNA6/STAT6/SHARPIN/PLA2G4F/VPS4A/FTL/IFNB1/FAF1/TNFRSF1A/IFNA2/VDAC3/MAPK9/IFNG/IFNA5/CHMP1A/CHMP4C/CHMP2A/CHMP3/VDAC2/SLC25A6/TRADD/CAPN1/TYK2/RBCK1/GLUD2/ALOX15/CHMP2B/IFNA1/HSP90AA1/CASP8/SMPD1/HSP90AB1/CHMP4A/CHMP6/IFNA14/SPATA2/SPATA2L/CAPN2/CHMP7/STAT5B/SLC25A5/IFNA16/PGAM5/PARP1/IFNA8/AIFM1/MAPK8/VPS4B/GLUD1/PYGB/USP21/CAMK2A/CHMP5/XIAP/RNF31/TRPM7/RIPK1/STAT3/SLC25A4/TNFRSF10B/JAK1/PYGM/CHMP4B/PPID/PLA2G4C/TRAF2/CAMK2G/IRF9/EIF2AK2/GLUL/DNM1L/TRAF5/BIRC2/BAX/FADD/VDAC1/MLKL/TICAM2/RIPK3/STAT2/PYGL/IFNGR1/IFNAR1/TNF/FTH1/CAMK2D/PYCARD/FAS/TLR3/TICAM1/CASP1/STAT1/CHMP1B/IFNA21/MAPK10/JAK2/TLR4/CYLD/CFLAR/IFNGR2/IFNAR2/BID/TNFSF10/STAT4/PLA2G4A	115
KEGG	hsa00860	Porphyrin metabolism	26/6848	43/8135	1	1	0.4286	ALAS2/COX15/FECH/UGT2B17/UGT1A6/ALAD/PPOX/UGT2A3/UGT2B15/COX10/HMOX2/UGT1A8/BLVRA/GUSB/UROD/MMAB/HCCS/BLVRB/UROS/ALAS1/FXN/CPOX/HMBS/HEPH/HMOX1/CP	26
KEGG	hsa00053	Ascorbate and aldarate metabolism	16/6848	30/8135	1	1	0.4286	MIOX/UGT2B17/UGT1A6/UGT2A3/UGT2B15/AKR1A1/UGT1A8/GUSB/KL/ALDH9A1/UGDH/ALDH2/ALDH7A1/ALDH3A2/ALDH1B1/RGN	16
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	44/6848	69/8135	1	1	0.4286	CYP3A43/CYP2A6/SULT2A1/CYP1A2/CYP2C9/CYP2C8/CYP2C18/CYP2C19/CYP3A4/SULT1A2/CYP3A7/CYP3A5/CYP2A13/UGT2B17/GSTA1/HSD11B1L/GSTP1/NAT2/UGT1A6/EPHX1/UGT2A3/UGT2B15/HPGDS/SULT1A1/UGT1A8/GSTA3/GSTM4/CYP2E1/MGST3/CBR1/CYP2A7/NAT1/GSTO2/CYP1A1/GSTM1/GSTK1/GSTA4/MGST1/GSTO1/MGST2/AKR1C2/GSTM3/GSTM5/CYP1B1	44
KEGG	hsa03010	Ribosome	112/6848	158/8135	1	1	0.4286	RPS27A/RPS23/RPL7A/RPS16/RPS28/RPS4X/RPL28/RPS13/RPLP0/RPL41/RPL8/RPL19/RPS10/RPS11/UBA52/RPS14/RPS6/RPS17/MRPL16/RPLP1/RPL11/RPL24/RPL10/RPL22/RPL3L/RPL39/RPL37/RPS27/RPS12/RPL30/RPL13A/RPL15/RPS3/RPS24/RPL38/RPL14/MRPS15/RPL27/RPL34/RPL5/MRPS14/RPS8/RPL10L/RPS2/RPL4/MRPL28/RPS20/RPS15A/RPL35/MRPL9/MRPS18A/FAU/RPS7/MRPS2/RPL29/RPS19/MRPL30/RPLP2/RPS29/RPL23A/RPL35A/MRPL2/MRPL11/RPS25/RPL3/RPL18/MRPS21/MRPL33/MRPL10/MRPL22/RPL36AL/RPL36A/RPS21/MRPL14/MRPL32/MRPS9/RPL12/RSL24D1/MRPL35/MRPL36/MRPL1/MRPS11/RPL26L1/MRPL4/RPL17/MRPS16/RPL36/MRPL27/MRPS17/RPL23/MRPL23/MRPL18/RPS27L/MRPL34/RPL31/MRPS7/MRPL13/RPL37A/MRPL24/MRPL3/MRPS5/MRPL21/MRPS10/MRPL15/MRPL20/MRPL17/MRPS18C/MRPS12/MRPL19/RPL27A/RPL22L1/MRPL12	112
KEGG	hsa00040	Pentose and glucuronate interconversions	18/6848	34/8135	1	1	0.4286	XYLB/DHDH/UGT2B17/UGT1A6/UGT2A3/UGT2B15/AKR1A1/UGT1A8/GUSB/RPE/KL/DCXR/SORD/AKR1B10/CRYL1/UGP2/UGDH/AKR1B1	18
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	72/6848	109/8135	1	1	0.4286	REXO1/RPP30/MDN1/XRN2/CSNK2B/NXF3/NMD3/CSNK2A1/POP4/FBL/SPATA5/REXO2/CSNK2A2/SBDS/NXT2/FCF1/SNU13/NOB1/RPP25L/UTP18/BMS1/TBL3/GNL3L/UTP14C/TCOF1/WDR75/POP5/NXF1/NVL/NOP10/DROSHA/NOL6/FBLL1/HEATR1/UTP14A/NHP2/UTP6/RCL1/RIOK2/REXO5/MPHOSPH10/UTP4/RPP25/RPP38/POP7/XRN1/NAT10/WDR36/GNL2/IMP3/RAN/XPO1/RBM28/NXT1/GAR1/WDR3/UTP15/RRP7A/PWP2/EFL1/EIF6/GNL3/LSG1/IMP4/DKC1/RIOK1/GTPBP4/POP1/EMG1/WDR43/NOP58/RPP40	72
KEGG	hsa04612	Antigen processing and presentation	47/6848	78/8135	1	1	0.4286	HLA-DQB1/HLA-DOA/KLRD1/HLA-DQA1/B2M/CIITA/KLRC4/CD8B/KLRC3/NFYC/HSPA6/CREB1/CD8A/KIR3DL1/IFNG/CD4/NFYA/RFXANK/HSP90AA1/HSP90AB1/CD74/HLA-G/KIR3DL2/PSME3/PSME1/HSPA4/CALR/PDIA3/CTSL/HSPA1A/LGMN/HLA-DPA1/HLA-F/RFX5/NFYB/TNF/HSPA5/HSPA1L/HLA-E/RFXAP/HLA-DRA/TAP1/IFI30/PSME2/TAP2/HSPA2/CTSS	47
KEGG	hsa05332	Graft-versus-host disease	21/6848	42/8135	1	1	0.4286	HLA-DQB1/HLA-DOA/KLRD1/CD86/FASLG/HLA-DQA1/PRF1/CD28/CD80/IL2/KIR3DL1/IFNG/GZMB/HLA-G/KIR3DL2/HLA-DPA1/HLA-F/TNF/FAS/HLA-E/HLA-DRA	21
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	23/6848	66/8135	1	1	0.4286	DARS2/QRSL1/IARS2/FARS2/GATB/SARS2/TARS2/RARS2/GATC/CARS2/YARS2/PSTK/AARS2/LARS2/WARS2/FARSB/SEPSECS/NARS2/PARS2/FARSA/HARS2/MTFMT/MARS2	23
KEGG	hsa04613	Neutrophil extracellular trap formation	105/6848	190/8135	1	1	0.4286	CLEC7A/CR1/SYK/HDAC3/PLCB2/ITGAL/CYBB/FGA/MAPK11/PRKCG/FPR2/HDAC6/PRKCB/HDAC8/SLC25A31/MPO/VWF/PADI4/TLR7/NCF4/ITGA2B/FPR3/TLR8/HMGB1/FGB/FPR1/MAPK12/CAMP/MAPK1/ATG7/SELP/AKT2/MAPK14/SIGLEC9/VDAC3/PLCG2/AZU1/MAPK3/SRC/FGG/RAF1/SELPLG/HDAC10/HDAC11/AKT1/VDAC2/SLC25A6/PLCG1/RAC1/PIK3R2/FCGR2A/ITGB3/PLCB3/C5AR1/ACTB/MAP3K7/ITGAM/CTSG/FCGR3B/AKT3/HDAC7/NCF1/MAP2K2/CR1L/PRKCA/HAT1/GSDMD/SLC25A5/HDAC4/CLCN5/RELA/GP1BA/HDAC1/SLC25A4/PIK3CB/ACTG1/CLCN3/PIK3R3/CYBA/ELANE/PIK3R1/HDAC2/MAP2K1/CLCN4/VDAC1/PPIF/MTOR/RAC2/PLCB1/C5/HDAC5/CASP4/PIK3CA/NCF2/PIK3CD/HDAC9/TLR2/CASP1/MAPK13/TLR4/PLCB4/ITGB2/AQP9/C3/NFKB1	105
KEGG	hsa04740	Olfactory transduction	103/6848	440/8135	1	1	0.4286	CNGB1/OR2H1/OR51E2/PDE1B/OR2L2/OR7C1/ARRB2/CAMK2B/PRKACB/OR2F1/PRKACA/SLC8A3/CALML4/PDE2A/SLC24A4/OR1I1/OR2C1/OR1E1/OR1F1/GRK2/GNG13/OR13C4/CNGA4/CALM2/OR8D2/OR51B5/OR2B3/SLC8A2/OR51B4/OR3A2/OR10J1/OR3A3/CALML6/OR4N4/OR5K1/OR2H2/OR2F2/OR4D1/OR5P2/OR6B1/OR4D2/CALM3/OR2L13/OR1G1/OR2C3/OR7A17/OR8B8/GRK3/OR3A1/OR2M4/OR2W1/OR51E1/OR2K2/OR7C2/OR1A2/OR10H3/OR5V1/OR1J2/OR11A1/CALML3/GNAL/PRKACG/ADCY3/OR14J1/OR12D3/OR6A2/OR2J3/GNB1/ANO2/OR7D2/CALML5/OR8D1/OR1Q1/OR10A3/CAMK2A/OR52D1/OR2A7/OR12D2/OR2B2/OR8G1/SLC8A1/OR1C1/OR10H2/OR1E2/OR1A1/OR2S2/CAMK2G/OR7A10/OR10A5/GUCY2D/OR7E24/GNG7/ARRB1/OR10A4/CALM1/PRKG1/NCALD/PDE1C/CAMK2D/CNGA3/PRKG2/PDE1A/RGS2	103
KEGG	hsa05034	Alcoholism	103/6848	187/8135	1	1	0.4286	GRIN1/GNAO1/GRIN3A/HDAC3/GNGT1/ATF2/GNG4/DRD2/HDAC6/SLC29A2/HDAC8/SLC18A2/PRKACB/GRIN2C/GNAS/CAMK4/PRKACA/CREB3L3/ARAF/MAPK1/SLC18A1/CALML4/GRIN2B/CRH/KRAS/CREB1/GNG13/GNAI3/MAPK3/PPP1CC/GNG3/RAF1/CALM2/HDAC10/HDAC11/GNB4/CAMKK2/PPP1R1B/CAMKK1/TH/SHC1/PDYN/PPP1CB/GNB2/CALML6/GNGT2/ATF6B/CALM3/GRB2/SLC6A3/GNG10/GRIN3B/ADCY5/GNG2/HDAC7/PPP1CA/GRIN2D/GNAI2/BRAF/SHC4/GNG8/CALML3/HAT1/PRKACG/CREB3L1/GNG5/SLC29A1/GNB1/HDAC4/SHC3/CALML5/CREB3/HDAC1/SOS2/NPY/HRAS/SOS1/GRIN2A/NRAS/GNG7/GNG12/CALM1/ATF4/HDAC2/CREB3L4/MAP2K1/NTRK2/GNB5/CREB3L2/SLC29A3/SHC2/HDAC5/DRD1/MAOA/HDAC9/GNAI1/GNG11/CREB5/PKIA/MAOB/BDNF/ADORA2B/FOSB	103
KEGG	hsa05206	MicroRNAs in cancer	156/6848	310/8135	1	1	0.4286	GLS2/ST14/ERBB3/IGF2BP1/TP63/PAK4/PDGFB/EFNA2/NOTCH3/PRKCG/PRKCB/ROCK1/MMP16/UBE2I/ERBB2/TP53/BCL2/TNR/PDGFRA/EFNA3/VIM/MAPK1/E2F2/WNT3/KRAS/APC2/SLC45A3/CDKN2A/EGFR/PLCG2/MAPK3/ABCB1/RAF1/FGFR3/CDC25C/IKBKB/SERPINB5/PLCG1/MDM4/RHOA/SHC1/E2F1/PIK3R2/FZD3/ITGB3/RDX/PRKCE/HNRNPK/DNMT3A/BCL2L11/GRB2/ITGA5/TNN/SHC4/MAP2K2/PTEN/PRKCA/APC/DICER1/RPTOR/CRKL/HDAC4/DNMT3B/ATM/CREBBP/GLS/CRK/HDAC1/NOTCH2/BMI1/NOTCH4/MDM2/STAT3/PIK3CB/NOTCH1/BRCA1/STMN1/MAPK7/CASP3/SOS2/E2F3/BCL2L2/MARCKS/DNMT1/HRAS/PIK3R3/ZEB1/SOS1/NRAS/CDKN1A/PDGFRB/PIK3R1/EP300/HDAC2/MAP2K1/CD44/HMGA2/SLC7A1/CDC25A/MMP9/RPS6KA5/MTOR/BMF/FOXP1/TPM1/EFNA4/MET/MYC/BAK1/FSCN1/HDAC5/PLAU/CCND2/ABL1/MCL1/PIK3CA/CCNE1/CDC25B/RASSF1/ABCC1/SIRT1/PIK3CD/EZR/SPRY2/CDCA5/VEGFA/KIF23/EZH2/SOCS1/RECK/ZEB2/TIMP3/CDK6/EFNA5/BMPR2/CCNE2/CCND1/PDCD4/THBS1/SOX4/TGFB2/HMOX1/CDKN1B/CYP24A1/ZFPM2/IRS1/DDIT4/EFNA1/PDGFA/MIR21/NFKB1/CYP1B1/TNC/IRS2/HOXD10/PIM1	156
KEGG	hsa05322	Systemic lupus erythematosus	41/6848	136/8135	1	1	0.4286	HLA-DQB1/HLA-DOA/CD86/HLA-DQA1/C8A/CD28/CD80/RO60/C1QC/GRIN2B/C1S/C1QA/IFNG/CD40LG/C8B/FCGR2A/CTSG/FCGR3B/ACTN4/C1QB/C6/C7/SNRPD3/C1R/C8G/C9/IL10/C2/SSB/SNRPB/ELANE/GRIN2A/HLA-DPA1/C5/TNF/SNRPD1/TRIM21/ACTN1/CD40/HLA-DRA/C3	41