ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04062	Chemokine signaling pathway	38/809	192/8135	2.386e-05	0.007754	0.006655	GNG11/PF4/PPBP/HCK/CXCL9/CXCL10/CCR5/STAT5B/PRKCB/ARRB2/PLCG2/GRK3/CCL8/CCL2/CX3CR1/CXCL11/GNG2/PIK3CG/GRK2/WAS/RAP1A/VAV1/GNAI2/CCL17/DOCK2/ADCY6/CCL21/RASGRP2/CCL22/ADCY9/CCL19/PRKCZ/CCL13/PIK3CD/SOS2/PIK3CB/CXCL13/GNB4	38
KEGG	hsa04068	FoxO signaling pathway	28/809	131/8135	6.883e-05	0.01038	0.008912	TGFBR1/CDK2/INSR/IRS2/CCND2/FBXO32/HOMER2/S1PR4/CCND1/EGF/CREBBP/RBL2/BCL2L11/GADD45B/STK4/KLF2/FOXO1/ATM/MAPK14/BNIP3/CDKN1B/IL10/SGK1/PIK3CD/SOS2/FOXO4/GADD45G/PIK3CB	28
KEGG	hsa01230	Biosynthesis of amino acids	19/809	75/8135	9.585e-05	0.01038	0.008912	NAGS/ASNS/MAT2A/SDS/BCAT2/SDSL/MAT1A/TPI1/ENO2/PFKP/PGK2/ARG1/ENO1/PKLR/GLUL/TKT/CTH/PRPS1L1/TALDO1	19
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	14/809	49/8135	0.000202	0.01641	0.01409	NANP/NANS/RENBP/HK2/PMM1/UGDH/MPI/GNPNAT1/UAP1L1/GNPDA1/FCSK/UAP1/CHIT1/GFPT1	14
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	38/809	222/8135	0.0005616	0.0216	0.01854	CCND3/TGFBR1/HLA-DPB1/ITGAL/HLA-DOA/CDK2/ATF2/STAT5B/TLN2/VAC14/ZFP36/CCND2/HLA-DRB1/ESPL1/SPI1/TLN1/CD40/SLC25A31/CDKN2C/CDK4/CSF2/NFATC3/CCND1/CREB5/CALR/CREBBP/ADCY6/BCL2L1/ANAPC15/IL1R1/SLC2A1/ATM/ADCY9/PIK3CD/PIK3CB/FOS/PTTG1/CREB3L2	38
KEGG	hsa04152	AMPK signaling pathway	24/809	120/8135	0.0006282	0.0216	0.01854	PPP2CB/PPP2R3A/INSR/IRS2/CPT1A/PPP2R5A/CAMKK2/EEF2K/GYS1/PPP2R5C/SREBF1/FBP1/RPTOR/PFKP/CCND1/LEPR/CREB5/PPARG/FOXO1/PIK3CD/PIK3CB/ULK1/SCD/CREB3L2	24
KEGG	hsa05202	Transcriptional misregulation in cancer	34/809	193/8135	0.0006371	0.0216	0.01854	NCOR1/SMAD1/HDAC1/NUPR1/PRCC/AFF1/CCND2/PLAU/KMT2A/SPI1/ETV5/KDM6A/CD40/CDKN2C/CSF2/LDB1/LMO2/ARNT2/PPARG/BCL2L1/GADD45B/NFKBIZ/MITF/FOXO1/ATM/SPINT1/CDKN1B/NSD2/JMJD1C/GADD45G/MAF/PER2/TLX3/SP1	34
KEGG	hsa00562	Inositol phosphate metabolism	17/809	73/8135	0.0006417	0.0216	0.01854	ITPKB/INPP1/IMPA2/PLCG2/OCRL/PI4K2A/PIK3CG/PLCZ1/TPI1/MTMR2/FIG4/INPP5D/ISYNA1/INPP4A/PIK3CD/PIK3CB/PIP5K1B	17
KEGG	hsa04115	p53 signaling pathway	17/809	73/8135	0.0006417	0.0216	0.01854	CCND3/CDK2/CCND2/STEAP3/SESN1/CDK4/CCND1/SESN3/EI24/BCL2L1/GADD45B/MDM4/AIFM2/ZMAT3/ATM/CASP8/GADD45G	17
KEGG	hsa01250	Biosynthesis of nucleotide sugars	11/809	37/8135	0.0006645	0.0216	0.01854	NANP/NANS/HK2/PMM1/UGDH/MPI/GNPNAT1/UAP1L1/FCSK/UAP1/GFPT1	11
KEGG	hsa04145	Phagosome	28/809	152/8135	0.0009181	0.02712	0.02328	HLA-DPB1/TUBB1/HLA-DOA/COLEC12/TUBA4A/RILP/HLA-DRB1/MSR1/OLR1/DYNC2H1/ATP6V1C2/ITGAV/CALR/CD209/NCF4/SFTPD/SEC61A1/MRC2/MARCO/CTSS/ATP6V0D2/TUBA1C/ITGB5/FCGR2B/LAMP1/C3/ITGA5/CTSL	28
KEGG	hsa00310	Lysine degradation	15/809	63/8135	0.00103	0.02791	0.02395	NSD3/PIPOX/SETD2/KMT2A/PLOD3/ALDH9A1/HYKK/ECHS1/SETD1B/PRDM2/ALDH1B1/NSD2/PLOD2/PHYKPL/CAMKMT	15
KEGG	hsa04510	Focal adhesion	34/809	201/8135	0.001329	0.03324	0.02853	CCND3/PARVB/ITGA1/VEGFA/TLN2/PRKCB/SPP1/VEGFD/CCND2/MYLPF/FYN/FN1/PPP1CA/VCL/ARHGAP5/COL4A1/TLN1/VWF/RAP1A/CCND1/EGF/VAV1/ITGAV/FLNB/ITGA2B/RAPGEF1/VEGFB/ITGB5/ACTN1/PIK3CD/SOS2/PIK3CB/ITGA5/PIP5K1B	34
KEGG	hsa04142	Lysosome	24/809	132/8135	0.002483	0.05487	0.0471	AP3M2/LGMN/SLC17A5/GGA2/ENTPD4/ACP5/LITAF/CTSZ/CTSB/AP1M1/LAMP3/LAPTM4B/CTNS/CTSV/HGSNAT/MANBA/FUCA1/NPC1/SLC11A2/CTSS/ATP6V0D2/LAMP1/CLTCL1/CTSL	24
KEGG	hsa04015	Rap1 signaling pathway	34/809	210/8135	0.002819	0.05487	0.0471	ITGAL/INSR/FYB1/VEGFA/TLN2/PRKCB/VEGFD/CTNND1/RALA/RALGDS/TLN1/CALML4/MAP2K6/RAP1A/EGF/VAV1/GNAI2/ITGA2B/ADCY6/RAPGEF1/VEGFB/RASGRP2/MAPK14/DOCK4/ADCY9/ANGPT1/RRAS/PRKCZ/LPAR5/PIK3CD/PIK3CB/PRKD2/KRIT1/RGS14	34
KEGG	hsa04070	Phosphatidylinositol signaling system	19/809	97/8135	0.002862	0.05487	0.0471	ITPKB/INPP1/IMPA2/PPIP5K1/PRKCB/CDS1/PLCG2/OCRL/PI4K2A/PLCZ1/CALML4/MTMR2/DGKG/INPP5D/INPP4A/PIK3CD/PIK3CB/DGKE/PIP5K1B	19
KEGG	hsa04110	Cell cycle	23/809	126/8135	0.00287	0.05487	0.0471	CCND3/HDAC1/CDK2/SMC3/CCND2/CDC14A/CDKN1C/DBF4/ESPL1/STAG2/CDKN2C/CDK4/CCND1/E2F5/CREBBP/RBL2/GADD45B/ANAPC15/ATM/CDKN1B/GADD45G/YWHAH/PTTG1	23
KEGG	hsa04514	Cell adhesion molecules	26/809	149/8135	0.00304	0.05489	0.04711	HLA-DPB1/ITGAL/HLA-DOA/CLDN2/SELL/SDC3/ICOSLG/L1CAM/HLA-DRB1/ICAM3/CD276/CD80/CD40/SELPLG/SDC4/VSIR/CD274/PTPRM/ITGAV/SDC2/ALCAM/NCAM2/NECTIN2/CLDN19/CADM1/LRRC4	26
KEGG	hsa04926	Relaxin signaling pathway	23/809	129/8135	0.003903	0.06632	0.05692	TGFBR1/GNG11/VEGFA/ATF2/VEGFD/ARRB2/MMP2/COL4A1/GNG2/CREB5/GNAI2/ADCY6/VEGFB/GNA15/MAPK14/ADCY9/PRKCZ/PIK3CD/SOS2/PIK3CB/GNB4/FOS/CREB3L2	23
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/809	100/8135	0.004081	0.06632	0.05692	TGFBR1/VEGFA/STAT5B/PRKCB/VEGFD/PLCG2/FN1/CCL2/MMP2/COL4A1/CDK4/CCND1/VEGFB/FOXO1/MAPK14/CDKN1B/PRKCZ/PIK3CD/PIK3CB	19
KEGG	hsa04213	Longevity regulating pathway - multiple species	13/809	62/8135	0.007017	0.1086	0.0932	HDAC1/INSR/IRS2/HSPA1B/HSPA1A/RPTOR/HSPA2/ADCY6/FOXO1/CLPB/ADCY9/PIK3CD/PIK3CB	13
KEGG	hsa04915	Estrogen signaling pathway	23/809	138/8135	0.009015	0.1244	0.1067	GPER1/NCOA1/ATF2/HSPA1B/HSPA1A/KRT27/NCOA3/NCOA2/MMP2/CALML4/HSPA2/CREB5/GNAI2/ADCY6/FKBP4/HSP90B1/ADCY9/PIK3CD/SOS2/PIK3CB/FOS/SP1/CREB3L2	23
KEGG	hsa04612	Antigen processing and presentation	15/809	78/8135	0.009033	0.1244	0.1067	HLA-DPB1/HLA-DOA/HSPA5/LGMN/CD74/HSPA1B/CIITA/HSPA1A/HLA-DRB1/CTSB/HSPA2/CALR/CTSS/PDIA3/CTSL	15
KEGG	hsa04520	Adherens junction	14/809	71/8135	0.009184	0.1244	0.1067	WASF1/TGFBR1/TCF7L2/INSR/SSX2IP/WASF2/FYN/CTNND1/VCL/WAS/PTPRM/CREBBP/NECTIN2/ACTN1	14
KEGG	hsa05223	Non-small cell lung cancer	14/809	72/8135	0.01039	0.1315	0.1129	STAT5B/PRKCB/PLCG2/CDK4/CCND1/EGF/GADD45B/STK4/FHIT/PIK3CD/SOS2/GADD45G/PIK3CB/EML4	14
KEGG	hsa04066	HIF-1 signaling pathway	19/809	109/8135	0.01052	0.1315	0.1129	INSR/LDHC/VEGFA/PRKCB/HK2/PLCG2/EGLN3/ENO2/PFKP/PGK2/EGF/CREBBP/ENO1/SLC2A1/ANGPT1/CDKN1B/PIK3CD/PIK3CB/TIMP1	19
KEGG	hsa04140	Autophagy - animal	23/809	141/8135	0.01161	0.1397	0.1199	PPP2CB/ZFYVE1/ULK2/IRS2/CAMKK2/RPTOR/CTSB/ATG2B/RAB39B/C9orf72/SNAP29/ATG16L2/EIF2AK4/RRAGC/BCL2L1/ATG2A/BNIP3/LAMP1/RRAS/PIK3CD/PIK3CB/ULK1/CTSL	23
KEGG	hsa00051	Fructose and mannose metabolism	8/809	33/8135	0.01348	0.1496	0.1284	ENOSF1/HK2/PMM1/FBP1/MPI/TPI1/PFKP/FCSK	8
KEGG	hsa04211	Longevity regulating pathway	16/809	89/8135	0.01358	0.1496	0.1284	INSR/IRS2/ATF2/CAMKK2/RPTOR/SESN1/SESN3/CREB5/PPARG/ADCY6/FOXO1/ADCY9/PIK3CD/PIK3CB/ULK1/CREB3L2	16
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	17/809	97/8135	0.01427	0.1496	0.1284	WASF1/HCK/PRKCB/WASF2/PLCG2/GSN/SPHK1/WAS/ACTR2/VAV1/PLPP3/SCIN/INPP5D/FCGR2B/PIK3CD/PIK3CB/PIP5K1B	17
KEGG	hsa05215	Prostate cancer	17/809	97/8135	0.01427	0.1496	0.1284	TCF7L2/CDK2/PLAU/ETV5/AR/CCND1/EGF/CREB5/CREBBP/HSP90B1/FOXO1/SPINT1/CDKN1B/PIK3CD/SOS2/PIK3CB/CREB3L2	17
KEGG	hsa05231	Choline metabolism in cancer	17/809	98/8135	0.01572	0.152	0.1305	WASF1/SLC44A2/PRKCB/WASF2/RALGDS/WAS/EGF/DGKG/PLPP3/CHKA/PIK3CD/SOS2/PIK3CB/DGKE/FOS/SP1/PIP5K1B	17
KEGG	hsa04910	Insulin signaling pathway	22/809	137/8135	0.0159	0.152	0.1305	INSR/IRS2/PHKA2/HK2/GYS1/SREBF1/PPP1CA/FBP1/RPTOR/CALML4/FLOT2/RAPGEF1/FLOT1/PKLR/PHKG2/FOXO1/PYGL/PPP1R3A/PRKCZ/PIK3CD/SOS2/PIK3CB	22
KEGG	hsa05135	Yersinia infection	22/809	137/8135	0.0159	0.152	0.1305	FYB1/WASF2/FN1/RHOG/CCL2/ELMO2/IRAK1/PKN2/WAS/ACTR2/MAP2K6/NFATC3/PYCARD/VAV1/GIT2/MAPK14/IL10/PIK3CD/PIK3CB/ITGA5/FOS/PIP5K1B	22
KEGG	hsa05418	Fluid shear stress and atherosclerosis	22/809	139/8135	0.0186	0.1682	0.1444	VEGFA/CCL2/MMP2/CALML4/DUSP1/SDC4/MAP2K6/ITGAV/SDC2/ITGA2B/MAP2K5/IL1R1/KLF2/HSP90B1/MAPK14/MEF2A/PRKCZ/GSTA4/PIK3CD/PIK3CB/FOS/CTSL	22
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/809	100/8135	0.01897	0.1682	0.1444	PF4/PPBP/CXCL9/CXCL10/CCR5/CCL8/CCL2/CX3CR1/CXCL11/CCL17/CCL21/CCL22/IL10/IL20/CCL19/CCL13/CXCL13	17
KEGG	hsa04931	Insulin resistance	18/809	108/8135	0.01943	0.1682	0.1444	INSR/IRS2/PRKCB/CPT1A/GYS1/SREBF1/PPP1CA/NR1H3/CREB5/SLC2A1/FOXO1/PYGL/PPP1R3A/PRKCZ/PIK3CD/PIK3CB/CREB3L2/GFPT1	18
KEGG	hsa04611	Platelet activation	20/809	124/8135	0.01996	0.1682	0.1444	P2RX1/GUCY1B1/TLN2/PLCG2/FYN/PPP1CA/TLN1/PIK3CG/VWF/RAP1A/GNAI2/ITGA2B/ADCY6/STIM1/RASGRP2/MAPK14/ADCY9/PRKCZ/PIK3CD/PIK3CB	20
KEGG	hsa05323	Rheumatoid arthritis	16/809	93/8135	0.02018	0.1682	0.1444	HLA-DPB1/ITGAL/HLA-DOA/VEGFA/ACP5/CCL2/HLA-DRB1/TNFRSF11A/CD80/CSF2/ATP6V1C2/LTB/ATP6V0D2/ANGPT1/FOS/CTSL	16
KEGG	hsa03018	RNA degradation	14/809	79/8135	0.02265	0.184	0.1579	EXOSC4/ENO2/PFKP/ZCCHC7/NUDT16/PAN2/PABPC3/ENO1/PATL1/HSPD1/LSM8/DCP2/DCP1B/DIS3L	14
KEGG	hsa04668	TNF signaling pathway	18/809	112/8135	0.02722	0.211	0.1811	ATF2/CXCL10/VEGFD/CCL2/TRAF3/MMP14/MAP2K6/CSF2/JUNB/CREB5/IRF1/MAPK14/CASP8/BAG4/PIK3CD/PIK3CB/FOS/CREB3L2	18
KEGG	hsa04380	Osteoclast differentiation	20/809	128/8135	0.02727	0.211	0.1811	TGFBR1/ACP5/TREM2/PLCG2/FYN/TNFRSF11A/SPI1/MAP2K6/JUNB/PPARG/LILRB2/NCF4/IL1R1/MITF/LILRB5/MAPK14/FCGR2B/PIK3CD/PIK3CB/FOS	20
KEGG	hsa04919	Thyroid hormone signaling pathway	19/809	121/8135	0.0295	0.223	0.1914	NCOR1/HDAC1/MED13L/NCOA1/PRKCB/PLCG2/NCOA3/NCOA2/PLCZ1/PFKP/CCND1/SLC16A10/ITGAV/CREBBP/ATP1B1/SLC2A1/FOXO1/PIK3CD/PIK3CB	19
KEGG	hsa00010	Glycolysis / Gluconeogenesis	12/809	67/8135	0.03094	0.2254	0.1934	GALM/LDHC/HK2/FBP1/ALDH9A1/TPI1/ENO2/PFKP/PGK2/ENO1/PKLR/ALDH1B1	12
KEGG	hsa01522	Endocrine resistance	16/809	98/8135	0.03158	0.2254	0.1934	NCOR1/GPER1/NCOA3/MMP2/CDKN2C/CDK4/CCND1/ADCY6/MAPK14/ADCY9/CDKN1B/PIK3CD/SOS2/PIK3CB/FOS/SP1	16
KEGG	hsa04670	Leukocyte transendothelial migration	18/809	114/8135	0.0319	0.2254	0.1934	ITGAL/CLDN2/PRKCB/MYLPF/PLCG2/CTNND1/VCL/ARHGAP5/MMP2/RAP1A/VAV1/GNAI2/NCF4/CLDN19/MAPK14/ACTN1/PIK3CD/PIK3CB	18
KEGG	hsa05162	Measles	21/809	139/8135	0.03357	0.2305	0.1978	CCND3/CDK2/STAT5B/HSPA1B/CCND2/HSPA1A/IRAK1/TRAF3/CDK4/HSPA2/CCND1/EIF2AK4/CD209/BCL2L1/EIF3H/CASP8/CDKN1B/FCGR2B/PIK3CD/PIK3CB/FOS	21
KEGG	hsa04151	PI3K-Akt signaling pathway	46/809	354/8135	0.03425	0.2305	0.1978	CCND3/PPP2CB/GNG11/ITGA1/CDK2/PPP2R3A/INSR/VEGFA/ATF2/SPP1/VEGFD/CCND2/PPP2R5A/GYS1/FN1/PPP2R5C/RPTOR/COL4A1/GNG2/PKN2/PIK3CG/VWF/CDK4/CCND1/EGF/CREB5/ITGAV/ITGA2B/BCL2L1/VEGFB/RBL2/BCL2L11/HSP90B1/CHRM1/ANGPT1/CDKN1B/SGK1/ITGB5/LPAR5/PIK3CD/SOS2/PIK3CB/GNB4/ITGA5/YWHAH/CREB3L2	46
KEGG	hsa04218	Cellular senescence	23/809	156/8135	0.03475	0.2305	0.1978	CCND3/TGFBR1/CDK2/MCU/CCND2/PPP1CA/CALML4/SLC25A31/CDK4/MAP2K6/NFATC3/CCND1/E2F5/RBL2/GADD45B/TRPM7/FOXO1/ATM/MAPK14/RRAS/PIK3CD/GADD45G/PIK3CB	23
KEGG	hsa05220	Chronic myeloid leukemia	13/809	76/8135	0.0356	0.2313	0.1985	TGFBR1/HDAC1/STAT5B/BCR/CDK4/CCND1/BCL2L1/GADD45B/CDKN1B/PIK3CD/SOS2/GADD45G/PIK3CB	13
KEGG	hsa04010	MAPK signaling pathway	39/809	294/8135	0.03685	0.2313	0.1985	TGFBR1/INSR/MAP4K2/VEGFA/ATF2/HSPA1B/PRKCB/NF1/VEGFD/ARRB2/HSPA1A/IRAK1/GNA12/PTPN7/DUSP1/HSPA2/MAP2K6/NFATC3/RAP1A/EGF/FLNB/DUSP10/MAP2K5/VEGFB/CACNA1H/GADD45B/IL1R1/STK4/RASGRP2/DUSP8/DUSP16/MAPK14/ANGPT1/PPM1B/RRAS/RASGRP4/SOS2/GADD45G/FOS	39
KEGG	hsa05222	Small cell lung cancer	15/809	92/8135	0.037	0.2313	0.1985	CDK2/FN1/TRAF3/COL4A1/CDK4/CCND1/ITGAV/ITGA2B/BCL2L1/GADD45B/FHIT/CDKN1B/PIK3CD/GADD45G/PIK3CB	15
KEGG	hsa05100	Bacterial invasion of epithelial cells	13/809	77/8135	0.0391	0.2397	0.2058	WASF1/ARHGAP10/WASF2/FN1/RHOG/ELMO2/VCL/ACTR2/PIK3CD/SEPTIN8/CLTCL1/PIK3CB/ITGA5	13
KEGG	hsa05165	Human papillomavirus infection	43/809	331/8135	0.03983	0.2397	0.2058	CCND3/PPP2CB/TCF7L2/HDAC1/ITGA1/CDK2/PPP2R3A/VEGFA/SPP1/CCND2/PPP2R5A/FN1/PPP2R5C/HES6/TRAF3/RBPJ/COL4A1/VWF/CDK4/HES7/CCND1/ATP6V1C2/EGF/HES4/CREB5/ITGAV/ITGA2B/CREBBP/RBL2/IRF1/FOXO1/ATM/ATP6V0D2/CASP8/CDKN1B/ITGB5/PRKCZ/PIK3CD/SOS2/PIK3CB/ITGA5/WNT11/CREB3L2	43
KEGG	hsa04810	Regulation of actin cytoskeleton	30/809	218/8135	0.04091	0.2418	0.2075	WASF1/SSH2/ITGAL/ITGA1/CYFIP2/FGD3/WASF2/MYLPF/FN1/PPP1CA/VCL/GSN/GNA12/ACTR2/EGF/VAV1/ITGAV/ITGA2B/SCIN/CHRM1/ITGB5/ACTN1/RRAS/LPAR5/PIK3CD/SOS2/PIK3CB/ABI2/ITGA5/PIP5K1B	30
KEGG	hsa04917	Prolactin signaling pathway	12/809	70/8135	0.04181	0.2427	0.2083	CISH/STAT5B/CCND2/TNFRSF11A/CCND1/SOCS6/IRF1/MAPK14/PIK3CD/SOS2/PIK3CB/FOS	12
KEGG	hsa05169	Epstein-Barr virus infection	28/809	202/8135	0.04351	0.2446	0.2099	CCND3/HLA-DPB1/HDAC1/ITGAL/HLA-DOA/CDK2/CXCL10/CCND2/PLCG2/HLA-DRB1/PSMD3/IRAK1/TRAF3/RBPJ/CD40/CDK4/MAP2K6/CCND1/CALR/BCL2L11/GADD45B/MAPK14/CASP8/CDKN1B/PIK3CD/PDIA3/GADD45G/PIK3CB	28
KEGG	hsa05146	Amoebiasis	16/809	102/8135	0.04365	0.2446	0.2099	CD1B/PRKCB/CD1E/FN1/SERPINB10/VCL/COL4A1/CSF2/ARG1/GNA15/IL1R1/IL10/ACTN1/PIK3CD/PIK3CB/CD1D	16
KEGG	hsa04935	Growth hormone synthesis, secretion and action	18/809	119/8135	0.04618	0.2544	0.2183	IRS2/ATF2/STAT5B/PRKCB/PLCG2/MAP2K6/JUNB/CREB5/GNAI2/CREBBP/ADCY6/MAPK14/ADCY9/PIK3CD/SOS2/PIK3CB/FOS/CREB3L2	18
KEGG	hsa04210	Apoptosis	20/809	136/8135	0.04774	0.2586	0.222	PARP2/TUBA4A/CTSZ/CTSB/LMNB2/CTSV/LMNA/BCL2L1/BCL2L11/GADD45B/CASP2/CTSS/ATM/CASP8/TUBA1C/PIK3CD/GADD45G/PIK3CB/FOS/CTSL	20
KEGG	hsa05145	Toxoplasmosis	17/809	112/8135	0.05022	0.2662	0.2285	HLA-DPB1/HLA-DOA/CCR5/HSPA1B/CIITA/HSPA1A/HLA-DRB1/IRAK1/PIK3CG/CD40/HSPA2/MAP2K6/GNAI2/BCL2L1/MAPK14/CASP8/IL10	17
KEGG	hsa04064	NF-kappa B signaling pathway	16/809	104/8135	0.05078	0.2662	0.2285	PRKCB/PLAU/PLCG2/TNFRSF11A/IRAK1/TRAF3/CD40/BCL2L1/GADD45B/CCL21/IL1R1/LTB/ATM/CCL19/CCL13/GADD45G	16
KEGG	hsa05417	Lipid and atherosclerosis	29/809	215/8135	0.05453	0.2813	0.2415	ABCG1/HSPA5/HSPA1B/POU2F2/HSPA1A/CCL2/IRAK1/TRAF3/OLR1/CALML4/CD40/HSPA2/MAP2K6/NFATC3/RAP1A/PYCARD/CYP2C8/VAV1/PPARG/NCF4/BCL2L1/HSP90B1/HSPD1/VLDLR/MAPK14/CASP8/PIK3CD/PIK3CB/FOS	29
KEGG	hsa04072	Phospholipase D signaling pathway	21/809	148/8135	0.0597	0.3032	0.2602	INSR/PTGFR/PLCG2/FYN/RALA/RALGDS/GNA12/SPHK1/PIK3CG/EGF/DGKG/PLPP3/ADCY6/ADCY9/RRAS/LPAR5/PIK3CD/SOS2/PIK3CB/DGKE/PIP5K1B	21
KEGG	hsa00340	Histidine metabolism	5/809	22/8135	0.06067	0.3034	0.2604	HAL/ALDH9A1/CARNMT1/CNDP2/ALDH1B1	5
KEGG	hsa00270	Cysteine and methionine metabolism	9/809	51/8135	0.0619	0.3048	0.2616	DNMT3B/LDHC/IL4I1/MAT2A/SDS/BCAT2/SDSL/MAT1A/CTH	9
KEGG	hsa04962	Vasopressin-regulated water reabsorption	8/809	44/8135	0.06565	0.3184	0.2733	DCTN5/DYNC2H1/CREB5/ARHGDIB/ADCY6/STX4/ADCY9/CREB3L2	8
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	7/809	37/8135	0.06896	0.3262	0.28	NEDD4L/INSR/PRKCB/ATP1B1/SGK1/PIK3CD/PIK3CB	7
KEGG	hsa05416	Viral myocarditis	10/809	60/8135	0.0702	0.3262	0.28	HLA-DPB1/ITGAL/HLA-DOA/FYN/ABL2/HLA-DRB1/CD80/CD40/CCND1/CASP8	10
KEGG	hsa05212	Pancreatic cancer	12/809	76/8135	0.07096	0.3262	0.28	TGFBR1/VEGFA/RALA/RALGDS/CDK4/CCND1/EGF/BCL2L1/GADD45B/PIK3CD/GADD45G/PIK3CB	12
KEGG	hsa00030	Pentose phosphate pathway	6/809	30/8135	0.07126	0.3262	0.28	FBP1/PGLS/PFKP/TKT/PRPS1L1/TALDO1	6
KEGG	hsa05211	Renal cell carcinoma	11/809	69/8135	0.07717	0.3483	0.299	PRCC/VEGFA/EGLN3/RAP1A/ARNT2/CREBBP/RAPGEF1/SLC2A1/PIK3CD/SOS2/PIK3CB	11
KEGG	hsa04930	Type II diabetes mellitus	8/809	46/8135	0.0813	0.3596	0.3087	INSR/IRS2/ABCC8/HK2/PKLR/PRKCZ/PIK3CD/PIK3CB	8
KEGG	hsa05210	Colorectal cancer	13/809	86/8135	0.08188	0.3596	0.3087	TGFBR1/TCF7L2/RALA/RALGDS/CCND1/EGF/BCL2L11/GADD45B/PIK3CD/SOS2/GADD45G/PIK3CB/FOS	13
KEGG	hsa05163	Human cytomegalovirus infection	29/809	225/8135	0.08663	0.3754	0.3222	GNG11/VEGFA/ATF2/CCR5/PRKCB/CCL2/GNA12/GNG2/CALML4/CDK4/MAP2K6/NFATC3/CCND1/CREB5/ITGAV/GNAI2/CALR/ADCY6/IL1R1/MAPK14/ADCY9/CASP8/PIK3CD/PDIA3/SOS2/PIK3CB/GNB4/SP1/CREB3L2	29
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/809	79/8135	0.08952	0.379	0.3253	VEGFA/PRKCB/NF1/PLCG2/AXL/EGF/BCL2L1/BCL2L11/NRG1/PIK3CD/SOS2/PIK3CB	12
KEGG	hsa04625	C-type lectin receptor signaling pathway	15/809	104/8135	0.08979	0.379	0.3253	PLCG2/CALML4/NFATC3/PYCARD/CCL17/CD209/IRF1/CLEC1B/CCL22/MAPK14/CASP8/IL10/RRAS/PIK3CD/PIK3CB	15
KEGG	hsa04725	Cholinergic synapse	16/809	113/8135	0.09288	0.387	0.3322	GNG11/PRKCB/FYN/GNG2/PIK3CG/CREB5/GNAI2/ADCY6/CHRM1/CHRNB4/ADCY9/PIK3CD/PIK3CB/GNB4/FOS/CREB3L2	16
KEGG	hsa04929	GnRH secretion	10/809	64/8135	0.09913	0.4046	0.3473	KCNN4/GPER1/PRKCB/SPP1/ARRB2/KCNN1/CACNA1H/PIK3CD/PIK3CB/TRPC1	10
KEGG	hsa04728	Dopaminergic synapse	18/809	132/8135	0.1032	0.4046	0.3473	PPP2CB/GNG11/PPP2R3A/ATF2/PRKCB/ARRB2/PPP2R5A/PPP2R5C/PPP1CA/GNG2/CALML4/CREB5/GNAI2/LRTOMT/MAPK14/GNB4/FOS/CREB3L2	18
KEGG	hsa04022	cGMP-PKG signaling pathway	22/809	167/8135	0.1036	0.4046	0.3473	GUCY1B1/INSR/IRS2/KCNMB1/ATF2/PPP1CA/GTF2IRD1/GNA12/PIK3CG/RGS2/CALML4/SLC25A31/NFATC3/CREB5/GNAI2/ADCY6/PDE2A/ATP1B1/MEF2A/ADCY9/ADRB2/CREB3L2	22
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	14/809	98/8135	0.1048	0.4046	0.3473	PRKCB/PLCG2/PPP1CA/HRH1/CALML4/PRKCH/MAP2K6/ADCY6/IL1R1/MAPK14/ADCY9/PIK3CD/PIK3CB/TRPV3	14
KEGG	hsa04922	Glucagon signaling pathway	15/809	107/8135	0.1081	0.4046	0.3473	LDHC/ATF2/CPT1A/PHKA2/GYS1/FBP1/CALML4/PFKP/CREB5/CREBBP/PHKG2/SLC2A1/FOXO1/PYGL/CREB3L2	15
KEGG	hsa01212	Fatty acid metabolism	9/809	57/8135	0.1084	0.4046	0.3473	HSD17B8/CPT1A/ECHS1/ACAA1/MECR/ACADSB/ACSBG2/SCD/HSD17B12	9
KEGG	hsa05134	Legionellosis	9/809	57/8135	0.1084	0.4046	0.3473	CR1/HSPA1B/HSPA1A/HSPA2/PYCARD/HSPD1/BNIP3/CASP8/C3	9
KEGG	hsa04672	Intestinal immune network for IgA production	8/809	49/8135	0.1086	0.4046	0.3473	HLA-DPB1/HLA-DOA/ICOSLG/HLA-DRB1/TNFRSF17/CD80/CD40/IL10	8
KEGG	hsa05132	Salmonella infection	31/809	249/8135	0.1108	0.4046	0.3473	TCF7L2/TUBB1/CYFIP2/RHOB/TUBA4A/RILP/STX10/DCTN5/MYLPF/RHOG/ELMO2/RALA/IRAK1/PIK3CG/DYNC2H1/ACTR2/MAP2K6/PYCARD/FLNB/HSP90B1/MAPK14/S100A10/CASP8/TUBA1C/RRAS/PIK3CD/PIK3CB/KPNA1/EXOC4/FOS/DYNLT3	31
KEGG	hsa05203	Viral carcinogenesis	26/809	204/8135	0.1108	0.4046	0.3473	CCND3/HDAC1/CDK2/ATF2/CCR5/STAT5B/VAC14/CCND2/GSN/TRAF3/RBPJ/CDK4/CCND1/CREB5/CREBBP/RBL2/SCIN/ATP6V0D2/CASP8/CDKN1B/ACTN1/PIK3CD/C3/PIK3CB/YWHAH/CREB3L2	26
KEGG	hsa04662	B cell receptor signaling pathway	12/809	82/8135	0.1108	0.4046	0.3473	PRKCB/PLCG2/NFATC3/VAV1/LILRB2/INPP5D/LILRB5/FCGR2B/PIK3CD/SOS2/PIK3CB/FOS	12
KEGG	hsa04014	Ras signaling pathway	29/809	232/8135	0.1155	0.417	0.3579	GNG11/INSR/PLA2G12A/VEGFA/PRKCB/NF1/VEGFD/PLCG2/ABL2/RALA/RALGDS/GNG2/CALML4/RAP1A/EGF/BCL2L1/VEGFB/STK4/RASAL2/RASGRP2/ANGPT1/RRAS/RASGRP4/PIK3CD/SOS2/FOXO4/PIK3CB/GNB4/RGL2	29
KEGG	hsa04918	Thyroid hormone synthesis	11/809	75/8135	0.1218	0.4302	0.3692	HSPA5/ATF2/PRKCB/GPX3/ASGR2/CREB5/ADCY6/ATP1B1/HSP90B1/ADCY9/CREB3L2	11
KEGG	hsa05214	Glioma	11/809	75/8135	0.1218	0.4302	0.3692	PRKCB/PLCG2/CALML4/CDK4/CCND1/EGF/GADD45B/PIK3CD/SOS2/GADD45G/PIK3CB	11
KEGG	hsa05221	Acute myeloid leukemia	10/809	67/8135	0.1248	0.4361	0.3743	TCF7L2/PPARD/STAT5B/SPI1/CSF2/CCND1/PIK3CD/SOS2/PIK3CB/PER2	10
KEGG	hsa00071	Fatty acid degradation	7/809	43/8135	0.1299	0.4472	0.3839	CPT1A/ALDH9A1/ECHS1/ACAA1/ACADSB/ACSBG2/ALDH1B1	7
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/809	20/8135	0.1307	0.4472	0.3839	B3GALT6/DSE/XYLT1/CSGALNACT2	4
KEGG	hsa05142	Chagas disease	14/809	102/8135	0.1333	0.4492	0.3856	PPP2CB/TGFBR1/CCL2/IRAK1/GNAI2/CALR/GNA15/MAPK14/CASP8/IL10/PIK3CD/C3/PIK3CB/FOS	14
KEGG	hsa04664	Fc epsilon RI signaling pathway	10/809	68/8135	0.1341	0.4492	0.3856	PLCG2/FYN/MAP2K6/CSF2/VAV1/INPP5D/MAPK14/PIK3CD/SOS2/PIK3CB	10
KEGG	hsa05140	Leishmaniasis	11/809	77/8135	0.1393	0.4619	0.3965	HLA-DPB1/HLA-DOA/CR1/PRKCB/HLA-DRB1/IRAK1/NCF4/MAPK14/IL10/C3/FOS	11
KEGG	hsa00500	Starch and sucrose metabolism	6/809	36/8135	0.1422	0.4659	0.3999	GYG1/HK2/GYS1/GBE1/PGM2L1/PYGL	6
KEGG	hsa04911	Insulin secretion	12/809	86/8135	0.1434	0.4659	0.3999	KCNN4/KCNMB1/ABCC8/ATF2/PRKCB/CREB5/KCNN1/ADCY6/ATP1B1/SLC2A1/ADCY9/CREB3L2	12
KEGG	hsa00561	Glycerolipid metabolism	9/809	61/8135	0.1479	0.4706	0.4039	ALDH9A1/MBOAT1/LPIN2/DGAT1/DGKG/PLPP3/LIPC/ALDH1B1/DGKE	9
KEGG	hsa04620	Toll-like receptor signaling pathway	14/809	104/8135	0.149	0.4706	0.4039	CXCL9/CXCL10/SPP1/CXCL11/IRAK1/TRAF3/CD80/CD40/MAP2K6/MAPK14/CASP8/PIK3CD/PIK3CB/FOS	14
KEGG	hsa00770	Pantothenate and CoA biosynthesis	4/809	21/8135	0.1495	0.4706	0.4039	VNN1/BCAT2/VNN2/ALDH1B1	4
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/809	194/8135	0.1534	0.4706	0.4039	GNG11/TCF7L2/HCK/VEGFA/CCR5/ZFP36/PLCG2/TRAF3/GNG2/PIK3CG/CALML4/CDK4/MAP2K6/CSF2/NFATC3/CCND1/CREBBP/MAPK14/CASP8/PIK3CD/C3/PIK3CB/GNB4/FOS	24
KEGG	hsa02010	ABC transporters	7/809	45/8135	0.1547	0.4706	0.4039	ABCG1/ABCC8/ABCC2/DEFB1/ABCA13/ABCB4/ABCA6	7
KEGG	hsa04020	Calcium signaling pathway	29/809	240/8135	0.1551	0.4706	0.4039	P2RX1/ITPKB/MCU/PTGFR/VEGFA/PRKCB/PHKA2/VEGFD/PLCG2/STIM2/HRH1/SPHK1/PLCZ1/CALML4/SLC25A31/EGF/VEGFB/CACNA1H/GNA15/STIM1/PHKG2/NTRK3/CHRM1/MCOLN3/P2RX7/ADCY9/ADRB2/CYSLTR1/RYR1	29
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	6/809	37/8135	0.1564	0.4706	0.4039	IL4I1/ASNS/ASRGL1/RIMKLB/GLUL/GFPT1	6
KEGG	hsa05216	Thyroid cancer	6/809	37/8135	0.1564	0.4706	0.4039	TCF7L2/TPR/CCND1/PPARG/GADD45B/GADD45G	6
KEGG	hsa04713	Circadian entrainment	13/809	97/8135	0.1638	0.4885	0.4192	GNG11/GUCY1B1/PRKCB/GNG2/CALML4/GNAI2/ADCY6/CACNA1H/ADCY9/GNB4/FOS/PER2/RYR1	13
KEGG	hsa01200	Carbon metabolism	15/809	115/8135	0.1669	0.493	0.4232	HK2/FBP1/SDS/SDSL/PGLS/ECHS1/TPI1/ENO2/PFKP/PGK2/ENO1/PKLR/TKT/PRPS1L1/TALDO1	15
KEGG	hsa04936	Alcoholic liver disease	18/809	142/8135	0.1684	0.493	0.4232	TCF7L2/CPT1A/CAMKK2/SREBF1/ALDH9A1/LPIN2/IL17RA/IRAK1/TRAF3/MAP2K6/CCND1/FOXO1/ALDH1B1/MAPK14/CASP8/TRA2B/C3/SCD	18
KEGG	hsa05330	Allograft rejection	6/809	38/8135	0.1712	0.4967	0.4263	HLA-DPB1/HLA-DOA/HLA-DRB1/CD80/CD40/IL10	6
KEGG	hsa04925	Aldosterone synthesis and secretion	13/809	98/8135	0.1728	0.4971	0.4267	ATF2/PRKCB/CYP11B2/DAGLA/CALML4/CREB5/ADCY6/CACNA1H/PDE2A/ATP1B1/ADCY9/PRKD2/CREB3L2	13
KEGG	hsa04137	Mitophagy - animal	10/809	72/8135	0.1747	0.498	0.4275	PINK1/TAX1BP1/BCL2L1/MITF/TBC1D15/NBR1/BNIP3/RRAS/ULK1/SP1	10
KEGG	hsa05152	Tuberculosis	22/809	180/8135	0.1805	0.5085	0.4364	HLA-DPB1/HLA-DOA/CR1/CD74/CIITA/HLA-DRB1/IRAK1/SPHK1/CALML4/CREBBP/CD209/MRC2/HSPD1/CTSS/ATP6V0D2/MAPK14/CASP8/IL10/FCGR2B/LAMP1/IRAK2/C3	22
KEGG	hsa04973	Carbohydrate digestion and absorption	7/809	47/8135	0.1816	0.5085	0.4364	PRKCB/TAS1R2/HK2/SLC2A5/ATP1B1/PIK3CD/PIK3CB	7
KEGG	hsa01240	Biosynthesis of cofactors	19/809	153/8135	0.183	0.5085	0.4364	PMM1/EARS2/MTHFD1L/COX15/UGDH/MAT2A/NADK/MPI/BCAT2/DHRS3/MAT1A/NAPRT/AK4/IDO1/LIAS/ALDH1B1/ALAD/CTPS1/PDXK	19
KEGG	hsa04340	Hedgehog signaling pathway	8/809	56/8135	0.1887	0.5141	0.4413	CCND2/ARRB2/GRK3/GRK2/CSNK1G3/CCND1/IHH/DISP1	8
KEGG	hsa04923	Regulation of lipolysis in adipocytes	8/809	56/8135	0.1887	0.5141	0.4413	INSR/IRS2/GNAI2/ADCY6/ADCY9/ADRB2/PIK3CD/PIK3CB	8
KEGG	hsa05310	Asthma	5/809	31/8135	0.1898	0.5141	0.4413	HLA-DPB1/HLA-DOA/HLA-DRB1/CD40/IL10	5
KEGG	hsa05131	Shigellosis	29/809	247/8135	0.1954	0.5213	0.4474	WASF1/TLN2/WASF2/HK2/MYLPF/PLCG2/ELMO2/RPTOR/VCL/TLN1/PLCZ1/ACTR2/CSF2/PYCARD/RRAGC/BCL2L1/IL1R1/FOXO1/ATM/MAPK14/BNIP3/FNBP1/ACTN1/PIK3CD/SEPTIN8/C3/FOXO4/PIK3CB/ITGA5	29
KEGG	hsa00280	Valine, leucine and isoleucine degradation	7/809	48/8135	0.1957	0.5213	0.4474	IL4I1/ALDH9A1/BCAT2/ECHS1/ACAA1/ACADSB/ALDH1B1	7
KEGG	hsa00230	Purine metabolism	16/809	128/8135	0.201	0.5238	0.4495	GUCY1B1/PDE6H/PFAS/PAICS/ENTPD4/IMPDH2/NUDT16/AK4/ADCY6/ATIC/PDE2A/FHIT/ADCY9/PRPS1L1/AMPD2/ENTPD6	16
KEGG	hsa04071	Sphingolipid signaling pathway	15/809	119/8135	0.2014	0.5238	0.4495	PPP2CB/PPP2R3A/PRKCB/PPP2R5A/FYN/PPP2R5C/GNA12/SPHK1/S1PR4/GNAI2/MAPK14/PRKCZ/PIK3CD/PIK3CB/SPTLC2	15
KEGG	hsa04722	Neurotrophin signaling pathway	15/809	119/8135	0.2014	0.5238	0.4495	IRAK3/PLCG2/IRAK1/CALML4/MAGED1/RAP1A/ARHGDIB/MAP2K5/RAPGEF1/NTRK3/MAPK14/IRAK2/PIK3CD/SOS2/PIK3CB	15
KEGG	hsa04136	Autophagy - other	5/809	32/8135	0.2079	0.5336	0.458	PPP2CB/ULK2/RPTOR/ATG2B/ATG2A	5
KEGG	hsa03320	PPAR signaling pathway	10/809	75/8135	0.2085	0.5336	0.458	PPARD/CPT1A/PLTP/OLR1/FABP3/NR1H3/ACAA1/PPARG/ACSBG2/SCD	10
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/809	24/8135	0.2112	0.5362	0.4602	B3GALT6/EXTL3/XYLT1/HS3ST5	4
KEGG	hsa05213	Endometrial cancer	8/809	58/8135	0.2153	0.5423	0.4655	TCF7L2/CCND1/EGF/GADD45B/PIK3CD/SOS2/GADD45G/PIK3CB	8
KEGG	hsa05133	Pertussis	10/809	76/8135	0.2204	0.5493	0.4714	IRAK1/CALML4/PYCARD/GNAI2/IRF1/MAPK14/IL10/C3/ITGA5/FOS	10
KEGG	hsa04974	Protein digestion and absorption	13/809	103/8135	0.2214	0.5493	0.4714	KCNN4/COL8A2/CELA3A/CPA2/SLC7A8/KCNK5/COL15A1/COL4A1/SLC16A10/ATP1B1/SLC7A7/SLC3A1/COL11A1	13
KEGG	hsa04979	Cholesterol metabolism	7/809	50/8135	0.2251	0.5526	0.4743	CETP/APOC1/PLTP/LRPAP1/NCEH1/LIPC/NPC1	7
KEGG	hsa05205	Proteoglycans in cancer	24/809	205/8135	0.2267	0.5526	0.4743	VEGFA/PRKCB/PLAU/PLCG2/FN1/PPP1CA/MMP2/HPSE2/SDC4/CCND1/VAV1/ITGAV/SDC2/IHH/FLNB/MAPK14/ITGB5/RRAS/PIK3CD/SOS2/PIK3CB/ITGA5/WNT11/CTSL	24
KEGG	hsa04114	Oocyte meiosis	16/809	131/8135	0.2278	0.5526	0.4743	PPP2CB/CDK2/SMC3/PPP2R5A/PPP2R5C/PPP1CA/ESPL1/PLCZ1/CALML4/AR/ADCY6/ANAPC15/MAPK14/ADCY9/YWHAH/PTTG1	16
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	18/809	150/8135	0.233	0.5609	0.4814	PPP2CB/PPP2R3A/ATF2/PPP2R5A/PPP2R5C/PPP1CA/PIK3CG/CALML4/TPM4/CREB5/GNAI2/ADCY6/ATP1B1/MAPK14/ADCY9/ADRB2/PPP1R1A/CREB3L2	18
KEGG	hsa00380	Tryptophan metabolism	6/809	42/8135	0.2353	0.5616	0.482	IL4I1/ALDH9A1/ECHS1/IDO1/CYP1B1/ALDH1B1	6
KEGG	hsa05130	Pathogenic Escherichia coli infection	23/809	197/8135	0.2367	0.5616	0.482	WASF1/TUBB1/CYFIP2/CLDN2/MYO1E/TUBA4A/WASF2/FYN/IRAK1/GNA12/ACTR2/PYCARD/MYO5B/IL1R1/SEC24D/CLDN19/MAPK14/MYO1C/CASP8/TUBA1C/LPAR5/MYO1F/FOS	23
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	13/809	106/8135	0.253	0.5913	0.5075	ATF2/PRKCB/ARRB2/GNA12/MMP14/CREB5/GNAI2/ADCY6/MEF2A/ADCY9/FOS/SP1/CREB3L2	13
KEGG	hsa04141	Protein processing in endoplasmic reticulum	20/809	171/8135	0.2535	0.5913	0.5075	HSPA5/DNAJC5G/LMAN1/HSPA1B/HYOU1/HSPA1A/YOD1/HSPH1/SSR3/HSPA2/EIF2AK4/RPN2/CALR/DERL2/STT3A/SEC61A1/HSP90B1/SEC24D/P4HB/PDIA3	20
KEGG	hsa04540	Gap junction	11/809	88/8135	0.2563	0.5913	0.5075	TUBB1/GUCY1B1/TUBA4A/PRKCB/EGF/GNAI2/ADCY6/MAP2K5/ADCY9/TUBA1C/SOS2	11
KEGG	hsa04630	JAK-STAT signaling pathway	19/809	162/8135	0.2565	0.5913	0.5075	CCND3/CISH/STAT5B/CCND2/IL13RA1/PIAS1/CSF2/CCND1/LEPR/EGF/SOCS6/CREBBP/IL27RA/BCL2L1/IL10/IL20/PIK3CD/SOS2/PIK3CB	19
KEGG	hsa00061	Fatty acid biosynthesis	3/809	18/8135	0.2633	0.6027	0.5173	HSD17B8/MECR/ACSBG2	3
KEGG	hsa04640	Hematopoietic cell lineage	12/809	99/8135	0.2778	0.6274	0.5385	HLA-DPB1/CD1B/ITGA1/HLA-DOA/CR1/CD1E/HLA-DRB1/CSF2/ITGA2B/IL1R1/ITGA5/CD1D	12
KEGG	hsa04934	Cushing syndrome	18/809	155/8135	0.278	0.6274	0.5385	TCF7L2/CDK2/ATF2/KMT2A/NCEH1/CDKN2C/CDK4/RAP1A/CCND1/CREB5/GNAI2/ADCY6/CACNA1H/ADCY9/CDKN1B/WNT11/SP1/CREB3L2	18
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	24/809	212/8135	0.2802	0.6281	0.5391	CCND3/VEGFA/ATF2/STAT5B/PRKCB/ARRB2/AR/CCND1/EGF/CREB5/GNAI2/ADCY6/CYP1B1/HSP90B1/CHRNB4/ADCY9/ADRB2/GSTA4/PIK3CD/SOS2/PIK3CB/KPNA1/FOS/CREB3L2	24
KEGG	hsa04144	Endocytosis	28/809	251/8135	0.2868	0.6385	0.548	TGFBR1/NEDD4L/RAB35/CCR5/HSPA1B/ARRB2/HSPA1A/GRK3/SMAP2/GRK2/VPS37C/HSPA2/RUFY1/RAB11FIP1/ACTR2/ACAP2/AGAP3/GIT2/VPS26B/SNX12/FOLR3/PSD3/PDCD6IP/EPS15/PRKCZ/CLTCL1/EHD3/PIP5K1B	28
KEGG	hsa05032	Morphine addiction	11/809	91/8135	0.293	0.6477	0.556	GNG11/PRKCB/ARRB2/GRK3/GNG2/GRK2/GNAI2/ADCY6/PDE2A/ADCY9/GNB4	11
KEGG	hsa01524	Platinum drug resistance	9/809	73/8135	0.2993	0.6573	0.5641	SLC31A1/ABCC2/ERCC1/BCL2L1/ATM/CASP8/GSTA4/PIK3CD/PIK3CB	9
KEGG	hsa04371	Apelin signaling pathway	16/809	139/8135	0.3059	0.6672	0.5726	TGFBR1/GNG11/SPP1/SPHK1/GNG2/PIK3CG/CALML4/CCND1/GNAI2/ADCY6/KLF2/MEF2A/ADCY9/RRAS/GNB4/RYR1	16
KEGG	hsa05225	Hepatocellular carcinoma	19/809	168/8135	0.311	0.6739	0.5784	TGFBR1/TCF7L2/PRKCB/PLCG2/FRAT1/SMARCD3/CDK4/CCND1/ARID1A/BCL2L1/GADD45B/ARID1B/GSTA4/PIK3CD/SOS2/GADD45G/PIK3CB/SMARCA2/WNT11	19
KEGG	hsa04927	Cortisol synthesis and secretion	8/809	65/8135	0.3173	0.6828	0.5861	ATF2/NCEH1/CREB5/ADCY6/CACNA1H/ADCY9/SP1/CREB3L2	8
KEGG	hsa04060	Cytokine-cytokine receptor interaction	32/809	295/8135	0.3269	0.6989	0.5999	TGFBR1/PF4/PPBP/TNFRSF12A/CXCL9/CXCL10/CCR5/CCL8/CCL2/TNFRSF11A/CX3CR1/CXCL11/BMP10/IL17RA/IL13RA1/TNFRSF17/CD40/CSF2/GDF9/LEPR/CCL17/IL27RA/CCL21/IL1R1/LTB/CCL22/IL10/IL20/CCL19/TNFRSF8/CCL13/CXCL13	32
KEGG	hsa04657	IL-17 signaling pathway	11/809	94/8135	0.331	0.7031	0.6035	CXCL10/CCL2/IL17RA/TRAF3/CSF2/CCL17/HSP90B1/MAPK14/CASP8/LCN2/FOS	11
KEGG	hsa04012	ErbB signaling pathway	10/809	85/8135	0.3365	0.7102	0.6096	STAT5B/PRKCB/PLCG2/ABL2/EGF/CDKN1B/NRG1/PIK3CD/SOS2/PIK3CB	10
KEGG	hsa04724	Glutamatergic synapse	13/809	114/8135	0.3439	0.7125	0.6116	GNG11/PRKCB/GRK3/GNG2/GRK2/HOMER2/SLC1A3/GNAI2/ADCY6/GLUL/ADCY9/GNB4/TRPC1	13
KEGG	hsa05161	Hepatitis B	18/809	162/8135	0.3454	0.7125	0.6116	TGFBR1/CDK2/ATF2/STAT5B/PRKCB/IRAK1/TRAF3/MAP2K6/NFATC3/CREB5/CREBBP/MAPK14/CASP8/PIK3CD/SOS2/PIK3CB/FOS/CREB3L2	18
KEGG	hsa00513	Various types of N-glycan biosynthesis	5/809	39/8135	0.3459	0.7125	0.6116	MGAT4A/MGAT1/RPN2/STT3A/MAN2A2	5
KEGG	hsa05017	Spinocerebellar ataxia	16/809	143/8135	0.3475	0.7125	0.6116	ULK2/MCU/PRKCB/PSMD3/RBPJ/ATG2B/SLC25A31/TWNK/VLDLR/ATG2A/PIK3CD/PIK3CB/PUM1/ULK1/RYR1/SP1	16
KEGG	hsa01523	Antifolate resistance	4/809	30/8135	0.3486	0.7125	0.6116	ABCC2/SLC19A1/ATIC/FOLR3	4
KEGG	hsa05150	Staphylococcus aureus infection	11/809	96/8135	0.3569	0.725	0.6222	HLA-DPB1/ITGAL/HLA-DOA/FPR3/KRT27/HLA-DRB1/DEFB1/SELPLG/IL10/FCGR2B/C3	11
KEGG	hsa04921	Oxytocin signaling pathway	17/809	154/8135	0.3619	0.7251	0.6224	GUCY1B1/PRKCB/CAMKK2/EEF2K/PPP1CA/PIK3CG/RGS2/CALML4/NFATC3/CCND1/GNAI2/ADCY6/MAP2K5/MYL6B/ADCY9/FOS/RYR1	17
KEGG	hsa00260	Glycine, serine and threonine metabolism	5/809	40/8135	0.3664	0.7251	0.6224	GATM/PIPOX/SDS/SDSL/CTH	5
KEGG	hsa03015	mRNA surveillance pathway	11/809	97/8135	0.37	0.7251	0.6224	PPP2CB/PPP2R3A/MSI2/PPP2R5A/PPP2R5C/PPP1CA/RNMT/PNN/PABPC3/CPSF1/NCBP2	11
KEGG	hsa04370	VEGF signaling pathway	7/809	59/8135	0.371	0.7251	0.6224	VEGFA/PRKCB/PLCG2/SPHK1/MAPK14/PIK3CD/PIK3CB	7
KEGG	hsa00410	beta-Alanine metabolism	4/809	31/8135	0.3721	0.7251	0.6224	ALDH9A1/ECHS1/CNDP2/ALDH1B1	4
KEGG	hsa00220	Arginine biosynthesis	3/809	22/8135	0.3765	0.7251	0.6224	NAGS/ARG1/GLUL	3
KEGG	hsa04512	ECM-receptor interaction	10/809	88/8135	0.3777	0.7251	0.6224	ITGA1/SPP1/FN1/COL4A1/VWF/SDC4/ITGAV/ITGA2B/ITGB5/ITGA5	10
KEGG	hsa05144	Malaria	6/809	50/8135	0.3787	0.7251	0.6224	ITGAL/CR1/CCL2/CD40/SDC2/IL10	6
KEGG	hsa05031	Amphetamine addiction	8/809	69/8135	0.3793	0.7251	0.6224	HDAC1/ATF2/PRKCB/PPP1CA/CALML4/CREB5/FOS/CREB3L2	8
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	8/809	69/8135	0.3793	0.7251	0.6224	NAT2/SULT1A2/CYP2A13/SULT1A1/CYP2C8/CYP1B1/GSTA4/HPGDS	8
KEGG	hsa00564	Glycerophospholipid metabolism	11/809	98/8135	0.3831	0.7281	0.6249	PLA2G12A/CDS1/MBOAT1/LPIN2/GNPAT/DGKG/PLPP3/LPCAT4/PISD/CHKA/DGKE	11
KEGG	hsa05219	Bladder cancer	5/809	41/8135	0.3869	0.7286	0.6254	VEGFA/MMP2/CDK4/CCND1/EGF	5
KEGG	hsa04730	Long-term depression	7/809	60/8135	0.3878	0.7286	0.6254	PPP2CB/GUCY1B1/PRKCB/PPP1R17/GNA12/GNAI2/RYR1	7
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/809	89/8135	0.3916	0.7292	0.6259	MAP2K6/NFATC3/CD274/EGF/MAPK14/BATF2/PIK3CD/PIK3CB/EML4/FOS	10
KEGG	hsa05160	Hepatitis C	17/809	157/8135	0.3931	0.7292	0.6259	PPP2CB/CDK2/CLDN2/CXCL10/TRAF3/PIAS1/NR1H3/CDK4/CCND1/EIF2AK4/EGF/CLDN19/CASP8/PIK3CD/SOS2/PIK3CB/YWHAH	17
KEGG	hsa05230	Central carbon metabolism in cancer	8/809	70/8135	0.395	0.7292	0.6259	LDHC/HK2/PFKP/SLC2A1/NTRK3/PIK3CD/PIK3CB/SLC16A3	8
KEGG	hsa00330	Arginine and proline metabolism	6/809	51/8135	0.3971	0.7292	0.6259	GATM/ALDH9A1/ARG1/CNDP2/P4HA1/ALDH1B1	6
KEGG	hsa03060	Protein export	3/809	23/8135	0.4045	0.7386	0.634	HSPA5/SEC61A1/SPCS3	3
KEGG	hsa05218	Melanoma	8/809	72/8135	0.4263	0.7724	0.6629	CDK4/CCND1/EGF/GADD45B/MITF/PIK3CD/GADD45G/PIK3CB	8
KEGG	hsa04940	Type I diabetes mellitus	5/809	43/8135	0.4278	0.7724	0.6629	HLA-DPB1/HLA-DOA/HLA-DRB1/CD80/HSPD1	5
KEGG	hsa05320	Autoimmune thyroid disease	6/809	53/8135	0.4339	0.7791	0.6687	HLA-DPB1/HLA-DOA/HLA-DRB1/CD80/CD40/IL10	6
KEGG	hsa05164	Influenza A	18/809	171/8135	0.4363	0.7792	0.6688	CCND3/HLA-DPB1/HLA-DOA/CXCL10/PRKCB/CIITA/CCL2/HLA-DRB1/TRAF3/SLC25A31/CDK4/PYCARD/CREBBP/NUP98/CASP8/PIK3CD/PIK3CB/KPNA1	18
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/809	15/8135	0.4481	0.7959	0.6831	ST6GALNAC3/ST6GALNAC4	2
KEGG	hsa04350	TGF-beta signaling pathway	10/809	94/8135	0.4609	0.8118	0.6968	SMAD1/PPP2CB/TGFBR1/E2F5/CREBBP/SMAD7/TGIF1/MICOS10-NBL1/NBL1/SP1	10
KEGG	hsa04660	T cell receptor signaling pathway	11/809	104/8135	0.4621	0.8118	0.6968	FYN/CDK4/CSF2/NFATC3/VAV1/MAPK14/IL10/PIK3CD/SOS2/PIK3CB/FOS	11
KEGG	hsa01232	Nucleotide metabolism	9/809	85/8135	0.4739	0.8223	0.7058	TK1/ENTPD4/IMPDH2/NUDT16/AK4/UCK2/AMPD2/CTPS1/ENTPD6	9
KEGG	hsa04610	Complement and coagulation cascades	9/809	85/8135	0.4739	0.8223	0.7058	CLU/CR1/PROCR/PLAU/A2M/F5/VSIG4/VWF/C3	9
KEGG	hsa00360	Phenylalanine metabolism	2/809	16/8135	0.4824	0.8223	0.7058	IL4I1/MIF	2
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/809	26/8135	0.4859	0.8223	0.7058	PIGB/PIGX/MPPE1	3
KEGG	hsa00350	Tyrosine metabolism	4/809	36/8135	0.4872	0.8223	0.7058	IL4I1/MIF/FAH/LRTOMT	4
KEGG	hsa00512	Mucin type O-glycan biosynthesis	4/809	36/8135	0.4872	0.8223	0.7058	GALNT10/ST6GALNAC3/ST6GALNAC1/ST6GALNAC4	4
KEGG	hsa04150	mTOR signaling pathway	16/809	156/8135	0.4875	0.8223	0.7058	INSR/ULK2/PRKCB/SEH1L/LPIN2/RPTOR/LAMTOR4/ATP6V1C2/RRAGC/SGK1/FNIP2/PIK3CD/SOS2/PIK3CB/ULK1/WNT11	16
KEGG	hsa05414	Dilated cardiomyopathy	10/809	96/8135	0.4883	0.8223	0.7058	ITGA1/TPM4/ITGAV/ITGA2B/LMNA/ADCY6/ADCY9/ITGB5/ITGA5/EMD	10
KEGG	hsa03040	Spliceosome	15/809	147/8135	0.4988	0.8313	0.7135	HSPA1B/HSPA1A/THOC2/RBM22/PPIL1/HSPA2/SF3B2/RBM17/PRPF4/CDC40/LSM8/SLU7/ZMAT2/NCBP2/TRA2B	15
KEGG	hsa05224	Breast cancer	15/809	147/8135	0.4988	0.8313	0.7135	TCF7L2/NCOA1/NCOA3/FRAT1/CDK4/CCND1/EGF/GADD45B/PIK3CD/SOS2/GADD45G/PIK3CB/FOS/WNT11/SP1	15
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/809	77/8135	0.5037	0.8332	0.7152	TCF7L2/ITGA1/ITGAV/ITGA2B/LMNA/ITGB5/ITGA5/EMD	8
KEGG	hsa00620	Pyruvate metabolism	5/809	47/8135	0.5075	0.8332	0.7152	LDHC/HAGH/ALDH9A1/PKLR/ALDH1B1	5
KEGG	hsa00062	Fatty acid elongation	3/809	27/8135	0.5118	0.8332	0.7152	ECHS1/MECR/HSD17B12	3
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	3/809	27/8135	0.5118	0.8332	0.7152	ACAA1/SCD/HSD17B12	3
KEGG	hsa03013	Nucleocytoplasmic transport	11/809	108/8135	0.5141	0.8332	0.7152	THOC5/SEH1L/THOC2/TPR/XPO5/PNN/RANBP17/NUP214/NUP98/NCBP2/KPNA1	11
KEGG	hsa00120	Primary bile acid biosynthesis	2/809	17/8135	0.5153	0.8332	0.7152	ACOT8/HSD3B7	2
KEGG	hsa04530	Tight junction	17/809	169/8135	0.5184	0.8341	0.7159	PPP2CB/NEDD4L/CD1B/CLDN2/TUBA4A/CD1E/CDK4/WAS/ACTR2/RAP1A/CCND1/MYL6B/CLDN19/TUBA1C/ACTN1/PRKCZ/CD1D	17
KEGG	hsa04727	GABAergic synapse	9/809	89/8135	0.5311	0.8503	0.7298	GNG11/PRKCB/GNG2/GNAI2/ADCY6/GLUL/ADCY9/GNB4/SLC12A5	9
KEGG	hsa05170	Human immunodeficiency virus 1 infection	21/809	212/8135	0.5423	0.8627	0.7404	GNG11/CCR5/PRKCB/PLCG2/IRAK1/AP1M1/GNG2/CALML4/MAP2K6/NFATC3/GNAI2/CALR/BCL2L1/ATM/MAPK14/CASP8/PIK3CD/PDIA3/PIK3CB/GNB4/FOS	21
KEGG	hsa05030	Cocaine addiction	5/809	49/8135	0.5456	0.8627	0.7404	ATF2/GPSM1/CREB5/GNAI2/CREB3L2	5
KEGG	hsa00511	Other glycan degradation	2/809	18/8135	0.5468	0.8627	0.7404	MANBA/FUCA1	2
KEGG	hsa04916	Melanogenesis	10/809	101/8135	0.5552	0.8695	0.7463	TCF7L2/PRKCB/CALML4/GNAI2/CREBBP/ADCY6/MITF/ADCY9/WNT11/CREB3L2	10
KEGG	hsa00510	N-Glycan biosynthesis	5/809	50/8135	0.5642	0.8695	0.7463	MGAT4A/MGAT1/RPN2/STT3A/MAN2A2	5
KEGG	hsa05110	Vibrio cholerae infection	5/809	50/8135	0.5642	0.8695	0.7463	PLCG2/ATP6V1C2/SEC61A1/ATP6V0D2/ADCY9	5
KEGG	hsa04658	Th1 and Th2 cell differentiation	9/809	92/8135	0.5725	0.8695	0.7463	HLA-DPB1/HLA-DOA/STAT5B/HLA-DRB1/RBPJ/NFATC3/MAPK14/MAF/FOS	9
KEGG	hsa00140	Steroid hormone biosynthesis	6/809	61/8135	0.5744	0.8695	0.7463	HSD17B8/CYP11B2/SULT2B1/CYP1B1/LRTOMT/HSD17B12	6
KEGG	hsa00590	Arachidonic acid metabolism	6/809	61/8135	0.5744	0.8695	0.7463	PLA2G12A/CBR3/GPX3/LTA4H/CYP2C8/HPGDS	6
KEGG	hsa00531	Glycosaminoglycan degradation	2/809	19/8135	0.5769	0.8695	0.7463	HPSE2/HGSNAT	2
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	2/809	19/8135	0.5769	0.8695	0.7463	NAGS/BCAT2	2
KEGG	hsa04913	Ovarian steroidogenesis	5/809	51/8135	0.5823	0.8695	0.7463	INSR/ADCY6/CYP1B1/ADCY9/FSHR	5
KEGG	hsa04932	Non-alcoholic fatty liver disease	15/809	155/8135	0.5849	0.8695	0.7463	INSR/IRS2/SREBF1/NR1H3/LEPR/PPARG/BCL2L11/PKLR/COX7A2L/UQCRB/MAPK14/CASP8/PIK3CD/PIK3CB/FOS	15
KEGG	hsa00053	Ascorbate and aldarate metabolism	3/809	30/8135	0.5851	0.8695	0.7463	ALDH9A1/UGDH/ALDH1B1	3
KEGG	hsa04912	GnRH signaling pathway	9/809	93/8135	0.5859	0.8695	0.7463	PRKCB/MMP2/CALML4/MMP14/MAP2K6/ADCY6/MAPK14/ADCY9/SOS2	9
KEGG	hsa04970	Salivary secretion	9/809	93/8135	0.5859	0.8695	0.7463	KCNN4/GUCY1B1/PRKCB/CALML4/ADCY6/ATP1B1/ADCY9/ADRB2/MUC7	9
KEGG	hsa03440	Homologous recombination	4/809	41/8135	0.5928	0.8758	0.7517	POLD2/BABAM2/ATM/UIMC1	4
KEGG	hsa00600	Sphingolipid metabolism	5/809	52/8135	0.6001	0.882	0.7571	KDSR/SPHK1/PLPP3/B4GALT6/SPTLC2	5
KEGG	hsa00670	One carbon pool by folate	2/809	20/8135	0.6054	0.882	0.7571	MTHFD1L/ATIC	2
KEGG	hsa00052	Galactose metabolism	3/809	31/8135	0.6079	0.882	0.7571	GALM/HK2/PFKP	3
KEGG	hsa04710	Circadian rhythm	3/809	31/8135	0.6079	0.882	0.7571	BHLHE40/BHLHE41/PER2	3
KEGG	hsa05332	Graft-versus-host disease	4/809	42/8135	0.6124	0.8845	0.7592	HLA-DPB1/HLA-DOA/HLA-DRB1/CD80	4
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/809	53/8135	0.6174	0.8878	0.762	PRKCB/ADCY6/ATP1B1/ADCY9/CLTCL1	5
KEGG	hsa04613	Neutrophil extracellular trap formation	18/809	190/8135	0.6232	0.8923	0.7659	HDAC1/ITGAL/H2AC11/CR1/PRKCB/FPR3/PLCG2/H2AJ/H2AC6/VWF/SLC25A31/SELPLG/ITGA2B/NCF4/MAPK14/PIK3CD/C3/PIK3CB	18
KEGG	hsa04215	Apoptosis - multiple species	3/809	32/8135	0.6299	0.8979	0.7706	BCL2L1/BCL2L11/CASP8	3
KEGG	hsa04971	Gastric acid secretion	7/809	76/8135	0.6418	0.9077	0.7791	PRKCB/CALML4/GNAI2/ADCY6/ATP1B1/KCNJ15/ADCY9	7
KEGG	hsa04659	Th17 cell differentiation	10/809	108/8135	0.6424	0.9077	0.7791	TGFBR1/HLA-DPB1/HLA-DOA/STAT5B/HLA-DRB1/NFATC3/IL27RA/IL1R1/MAPK14/FOS	10
KEGG	hsa03410	Base excision repair	3/809	33/8135	0.651	0.912	0.7827	PARP2/LIG3/POLD2	3
KEGG	hsa04130	SNARE interactions in vesicular transport	3/809	33/8135	0.651	0.912	0.7827	STX6/SNAP29/STX4	3
KEGG	hsa00900	Terpenoid backbone biosynthesis	2/809	22/8135	0.6581	0.9179	0.7878	IDI1/RCE1	2
KEGG	hsa04720	Long-term potentiation	6/809	67/8135	0.6674	0.9245	0.7935	PRKCB/PPP1CA/CALML4/RAP1A/CREBBP/PPP1R1A	6
KEGG	hsa04721	Synaptic vesicle cycle	7/809	78/8135	0.6691	0.9245	0.7935	UNC13B/SLC1A3/ATP6V1C2/CPLX1/STXBP1/ATP6V0D2/CLTCL1	7
KEGG	hsa04976	Bile secretion	8/809	89/8135	0.6714	0.9245	0.7935	ABCC2/SLC51A/NCEH1/ADCY6/ABCB4/ATP1B1/SLC2A1/ADCY9	8
KEGG	hsa05410	Hypertrophic cardiomyopathy	8/809	90/8135	0.6837	0.9375	0.8047	ITGA1/TPM4/ITGAV/ITGA2B/LMNA/ITGB5/ITGA5/EMD	8
KEGG	hsa04920	Adipocytokine signaling pathway	6/809	69/8135	0.6953	0.9399	0.8067	IRS2/CPT1A/CAMKK2/LEPR/SLC2A1/ACSBG2	6
KEGG	hsa04924	Renin secretion	6/809	69/8135	0.6953	0.9399	0.8067	GUCY1B1/CTSB/CALML4/GNAI2/ADCY6/ADRB2	6
KEGG	hsa04972	Pancreatic secretion	9/809	102/8135	0.6969	0.9399	0.8067	CELA3A/PLA2G12A/CPA2/PRKCB/RAP1A/ADCY6/ATP1B1/ADCY9/TRPC1	9
KEGG	hsa00240	Pyrimidine metabolism	5/809	58/8135	0.697	0.9399	0.8067	TK1/ENTPD4/UCK2/CTPS1/ENTPD6	5
KEGG	hsa00514	Other types of O-glycan biosynthesis	4/809	47/8135	0.7009	0.9413	0.8079	GALNT10/PLOD3/XXYLT1/B3GLCT	4
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	3/809	36/8135	0.7091	0.9437	0.81	NADK/NAPRT/SIRT5	3
KEGG	hsa04714	Thermogenesis	21/809	232/8135	0.7099	0.9437	0.81	SLC25A20/ATF2/CPT1A/COA7/ZNF516/COX15/RPTOR/SMARCD3/CREB5/PPARG/ARID1A/ADCY6/ARID1B/COX7A2L/UQCRB/KDM3A/MAPK14/ADCY9/SOS2/SMARCA2/CREB3L2	21
KEGG	hsa04330	Notch signaling pathway	5/809	59/8135	0.7114	0.9437	0.81	HDAC1/DTX4/RBPJ/TLE4/CREBBP	5
KEGG	hsa04146	Peroxisome	7/809	82/8135	0.7197	0.9508	0.8161	ACOT8/PIPOX/ECH1/GNPAT/NUDT19/ACAA1/PEX5	7
KEGG	hsa00592	alpha-Linolenic acid metabolism	2/809	25/8135	0.7263	0.9521	0.8172	PLA2G12A/ACAA1	2
KEGG	hsa05143	African trypanosomiasis	3/809	37/8135	0.7267	0.9521	0.8172	PRKCB/IDO1/IL10	3
KEGG	hsa05226	Gastric cancer	13/809	149/8135	0.732	0.9521	0.8172	TGFBR1/TCF7L2/CDK2/FRAT1/CCND1/EGF/GADD45B/CDKN1B/PIK3CD/SOS2/GADD45G/PIK3CB/WNT11	13
KEGG	hsa05415	Diabetic cardiomyopathy	18/809	203/8135	0.7324	0.9521	0.8172	TGFBR1/PDK4/INSR/PRKCB/GYS1/PPP1CA/MMP2/SLC25A31/NCF4/COX7A2L/SLC2A1/UQCRB/MAPK14/PRKCZ/PIK3CD/PIK3CB/SP1/GFPT1	18
KEGG	hsa05340	Primary immunodeficiency	3/809	38/8135	0.7435	0.9596	0.8236	CIITA/CD40/DCLRE1C	3
KEGG	hsa03450	Non-homologous end-joining	1/809	13/8135	0.744	0.9596	0.8236	DCLRE1C	1
KEGG	hsa04621	NOD-like receptor signaling pathway	16/809	184/8135	0.752	0.9659	0.8291	MCU/CCL2/CTSB/TRAF3/PKN2/TRIP6/PYCARD/GBP1/CARD8/BCL2L1/TRPM7/NLRP12/NLRP1/P2RX7/MAPK14/CASP8	16
KEGG	hsa03250	Viral life cycle - HIV-1	5/809	63/8135	0.7644	0.9684	0.8312	CCR5/PSIP1/CREBBP/PDCD6IP/NELFA	5
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/809	27/8135	0.7651	0.9684	0.8312	ST3GAL6/B3GNT5	2
KEGG	hsa04966	Collecting duct acid secretion	2/809	27/8135	0.7651	0.9684	0.8312	ATP6V1C2/ATP6V0D2	2
KEGG	hsa04120	Ubiquitin mediated proteolysis	12/809	142/8135	0.7658	0.9684	0.8312	NEDD4L/UBE2R2/SAE1/UBE2E2/HERC3/UBA3/PIAS1/FBXW7/ANAPC15/HERC1/UBA2/HERC2	12
KEGG	hsa05034	Alcoholism	16/809	187/8135	0.7741	0.9751	0.837	GNG11/HDAC1/H2AC11/SLC29A3/ATF2/CAMKK2/PPP1CA/H2AJ/H2AC6/GNG2/CALML4/CREB5/GNAI2/SOS2/GNB4/CREB3L2	16
KEGG	hsa04024	cAMP signaling pathway	19/809	221/8135	0.7829	0.9763	0.8379	SUCNR1/PPP1CA/CALML4/RAP1A/CREB5/VAV1/GNAI2/CREBBP/ADCY6/ATP1B1/CHRM1/ADCY9/ADRB2/RRAS/PIK3CD/PIK3CB/FSHR/FOS/CREB3L2	19
KEGG	hsa05321	Inflammatory bowel disease	5/809	65/8135	0.7879	0.9763	0.8379	HLA-DPB1/HLA-DOA/HLA-DRB1/IL10/MAF	5
KEGG	hsa04216	Ferroptosis	3/809	41/8135	0.7889	0.9763	0.8379	SLC39A14/STEAP3/SLC11A2	3
KEGG	hsa04270	Vascular smooth muscle contraction	11/809	134/8135	0.7912	0.9763	0.8379	GUCY1B1/PLA2G12A/KCNMB1/PRKCB/PPP1CA/GNA12/CALML4/PRKCH/ADCY6/MYL6B/ADCY9	11
KEGG	hsa00730	Thiamine metabolism	1/809	15/8135	0.7925	0.9763	0.8379	AK4	1
KEGG	hsa04390	Hippo signaling pathway	13/809	157/8135	0.7963	0.9763	0.8379	SMAD1/CCND3/PPP2CB/TGFBR1/TCF7L2/CCND2/PPP1CA/SAV1/CCND1/SMAD7/PRKCZ/WNT11/YWHAH	13
KEGG	hsa00591	Linoleic acid metabolism	2/809	29/8135	0.799	0.9763	0.8379	PLA2G12A/CYP2C8	2
KEGG	hsa04392	Hippo signaling pathway - multiple species	2/809	29/8135	0.799	0.9763	0.8379	RASSF2/SAV1	2
KEGG	hsa05322	Systemic lupus erythematosus	11/809	136/8135	0.8067	0.9778	0.8392	HLA-DPB1/H2AC11/HLA-DOA/HLA-DRB1/H2AJ/H2AC6/CD80/CD40/IL10/ACTN1/C3	11
KEGG	hsa04914	Progesterone-mediated oocyte maturation	8/809	102/8135	0.8082	0.9778	0.8392	CDK2/GNAI2/ADCY6/ANAPC15/MAPK14/ADCY9/PIK3CD/PIK3CB	8
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	2/809	30/8135	0.8143	0.9778	0.8392	HYI/GLUL	2
KEGG	hsa00860	Porphyrin metabolism	3/809	43/8135	0.8153	0.9778	0.8392	EARS2/COX15/ALAD	3
KEGG	hsa04975	Fat digestion and absorption	3/809	43/8135	0.8153	0.9778	0.8392	PLA2G12A/DGAT1/PLPP3	3
KEGG	hsa00830	Retinol metabolism	5/809	68/8135	0.8198	0.9795	0.8407	DHRS3/DGAT1/CYP2C8/ALDH1A2/DHRS9	5
KEGG	hsa05020	Prion disease	23/809	273/8135	0.8302	0.983	0.8437	TUBB1/HSPA5/MCU/TUBA4A/ATF2/HSPA1B/FYN/HSPA1A/PSMD3/STIP1/SLC25A31/HSPA2/CREB5/NCF4/NCAM2/COX7A2L/UQCRB/MAPK14/TUBA1C/PIK3CD/PIK3CB/RYR1/CREB3L2	23
KEGG	hsa00450	Selenocompound metabolism	1/809	17/8135	0.8318	0.983	0.8437	CTH	1
KEGG	hsa00910	Nitrogen metabolism	1/809	17/8135	0.8318	0.983	0.8437	GLUL	1
KEGG	hsa03022	Basal transcription factors	3/809	45/8135	0.8389	0.9844	0.8449	TAF10/GTF2IRD1/TAF8	3
KEGG	hsa00640	Propanoate metabolism	2/809	32/8135	0.8418	0.9844	0.8449	LDHC/ECHS1	2
KEGG	hsa00480	Glutathione metabolism	4/809	58/8135	0.8421	0.9844	0.8449	GGCT/GPX3/GSTA4/HPGDS	4
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	10/809	131/8135	0.8517	0.9922	0.8516	ITGAL/PRKCB/PLCG2/FYN/CSF2/VAV1/SH2D1B/PIK3CD/SOS2/PIK3CB	10
KEGG	hsa04310	Wnt signaling pathway	13/809	167/8135	0.8601	0.9928	0.8521	CCND3/TCF7L2/SERPINF1/PPARD/PRKCB/CCND2/FRAT1/PRICKLE1/TLE4/NFATC3/CCND1/CREBBP/WNT11	13
KEGG	hsa04978	Mineral absorption	4/809	60/8135	0.8606	0.9928	0.8521	SLC31A1/ATP1B1/TRPM7/SLC11A2	4
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	8/809	109/8135	0.8614	0.9928	0.8521	HEATR1/GNL3/RCL1/NAT10/NOP58/MDN1/GTPBP4/RIOK1	8
KEGG	hsa00100	Steroid biosynthesis	1/809	20/8135	0.8772	1	0.8583	FDFT1	1
KEGG	hsa00565	Ether lipid metabolism	3/809	49/8135	0.8783	1	0.8583	PLA2G12A/PLPP3/LPCAT4	3
KEGG	hsa05217	Basal cell carcinoma	4/809	63/8135	0.8849	1	0.8583	TCF7L2/GADD45B/GADD45G/WNT11	4
KEGG	hsa04726	Serotonergic synapse	8/809	115/8135	0.8969	1	0.8583	GNG11/PRKCB/GNG2/DUSP1/CYP2C8/GNAI2/GNB4/TRPC1	8
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/809	78/8135	0.899	1	0.8583	CBR3/CYP2A13/CYP1B1/GSTA4/HPGDS	5
KEGG	hsa03430	Mismatch repair	1/809	23/8135	0.9104	1	0.8583	POLD2	1
KEGG	hsa04614	Renin-angiotensin system	1/809	23/8135	0.9104	1	0.8583	LNPEP	1
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	1/809	23/8135	0.9104	1	0.8583	ATP1B1	1
KEGG	hsa00983	Drug metabolism - other enzymes	5/809	80/8135	0.9106	1	0.8583	TK1/IMPDH2/NAT2/UCK2/GSTA4	5
KEGG	hsa05016	Huntington disease	24/809	306/8135	0.9151	1	0.8583	HDAC1/TUBB1/ULK2/DNAH12/TUBA4A/GPX3/TGM2/DCTN5/PSMD3/ATG2B/SLC25A31/SLC1A3/CREB5/PPARG/CREBBP/COX7A2L/UQCRB/ATG2A/CASP8/TUBA1C/CLTCL1/ULK1/SP1/CREB3L2	24
KEGG	hsa04977	Vitamin digestion and absorption	1/809	24/8135	0.9194	1	0.8583	SLC19A1	1
KEGG	hsa04360	Axon guidance	13/809	182/8135	0.9252	1	0.8583	SSH2/PLCG2/FYN/L1CAM/PLXNA3/NFATC3/GNAI2/RRAS/PRKCZ/PIK3CD/PIK3CB/TRPC1/LRRC4	13
KEGG	hsa05206	MicroRNAs in cancer	24/809	310/8135	0.926	1	0.8583	HDAC1/IRS2/DNMT3B/VEGFA/PRKCB/CCND2/PLAU/SLC7A1/PLCG2/RPTOR/RECK/CCND1/CREBBP/SOX4/BCL2L11/MDM4/CYP1B1/ATM/CDKN1B/FOXP1/PIK3CD/SOS2/PIK3CB/ITGA5	24
KEGG	hsa04622	RIG-I-like receptor signaling pathway	4/809	70/8135	0.9277	1	0.8583	CXCL10/TRAF3/MAPK14/CASP8	4
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/809	70/8135	0.9277	1	0.8583	PLCG2/ATP6V1C2/ATP6V0D2/MAPK14	4
KEGG	hsa04950	Maturity onset diabetes of the young	1/809	26/8135	0.9346	1	0.8583	PKLR	1
KEGG	hsa05014	Amyotrophic lateral sclerosis	28/809	364/8135	0.9446	1	0.8583	TUBB1/HSPA5/ULK2/MCU/DNAH12/TUBA4A/GPX3/SEH1L/DCTN5/TPR/PSMD3/SPG11/PINK1/ATG2B/RAB39B/C9orf72/MAP2K6/FIG4/BCL2L1/NUP214/COX7A2L/UQCRB/NUP98/MAPK14/ATG2A/TUBA1C/NRG1/ULK1	28
KEGG	hsa00650	Butanoate metabolism	1/809	28/8135	0.947	1	0.8583	ECHS1	1
KEGG	hsa03050	Proteasome	2/809	46/8135	0.9513	1	0.8583	PSMD3/PSME4	2
KEGG	hsa04744	Phototransduction	1/809	29/8135	0.9523	1	0.8583	CALML4	1
KEGG	hsa03420	Nucleotide excision repair	2/809	47/8135	0.9554	1	0.8583	POLD2/ERCC1	2
KEGG	hsa04623	Cytosolic DNA-sensing pathway	3/809	63/8135	0.9573	1	0.8583	CXCL10/POLR3H/PYCARD	3
KEGG	hsa05171	Coronavirus disease - COVID-19	16/809	232/8135	0.9598	1	0.8583	CXCL10/PRKCB/PLCG2/CCL2/IRAK1/TRAF3/VWF/RPL7/CSF2/RPL12/MAPK14/RPS24/PIK3CD/C3/PIK3CB/FOS	16
KEGG	hsa04217	Necroptosis	10/809	159/8135	0.9617	1	0.8583	H2AC11/STAT5B/H2AJ/H2AC6/SLC25A31/PYCARD/TRPM7/GLUL/CASP8/PYGL	10
KEGG	hsa04723	Retrograde endocannabinoid signaling	9/809	148/8135	0.9652	1	0.8583	GNG11/PRKCB/DAGLA/GNG2/GNAI2/ADCY6/MAPK14/ADCY9/GNB4	9
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	3/809	66/8135	0.9662	1	0.8583	AARS1/EARS2/CARS2	3
KEGG	hsa00040	Pentose and glucuronate interconversions	1/809	34/8135	0.9718	1	0.8583	UGDH	1
KEGG	hsa03020	RNA polymerase	1/809	34/8135	0.9718	1	0.8583	POLR3H	1
KEGG	hsa03460	Fanconi anemia pathway	2/809	54/8135	0.976	1	0.8583	ERCC1/POLI	2
KEGG	hsa03030	DNA replication	1/809	36/8135	0.9772	1	0.8583	POLD2	1
KEGG	hsa04260	Cardiac muscle contraction	4/809	87/8135	0.9786	1	0.8583	TPM4/ATP1B1/COX7A2L/UQCRB	4
KEGG	hsa00982	Drug metabolism - cytochrome P450	3/809	72/8135	0.9791	1	0.8583	CYP2C8/GSTA4/HPGDS	3
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/809	223/8135	0.9809	1	0.8583	VEGFA/ABL2/SLC25A31/EGF/CYP1B1/COX7A2L/UQCRB/MAPK14/GSTA4/PIK3CD/SOS2/PIK3CB/FOS/PRKD2	14
KEGG	hsa05012	Parkinson disease	17/809	266/8135	0.9854	1	0.8583	TUBB1/HSPA5/MCU/TUBA4A/SLC39A14/PSMD3/PINK1/CALML4/DUSP1/SLC25A31/GNAI2/BCL2L1/COX7A2L/SLC11A2/UQCRB/LRRK2/TUBA1C	17
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/809	143/8135	0.991	1	0.8583	SMAD1/SKIL/MYF5/MAPK14/PIK3CD/PIK3CB/WNT11	7
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	33/809	476/8135	0.9927	1	0.8583	TUBB1/HSPA5/ZFYVE1/ULK2/MCU/DNAH12/TUBA4A/PRKCB/GPX3/DCTN5/FRAT1/PSMD3/SPG11/PINK1/ATG2B/RAB39B/CALML4/SLC25A31/C9orf72/MAP2K6/FIG4/BCL2L1/COX7A2L/UQCRB/CHRM1/LRRK2/MAPK14/ATG2A/CASP8/TUBA1C/ULK1/WNT11/RYR1	33
KEGG	hsa04742	Taste transduction	3/809	86/8135	0.9935	1	0.8583	TAS1R2/KCNK5/ADCY6	3
KEGG	hsa05010	Alzheimer disease	24/809	384/8135	0.9967	1	0.8583	TUBB1/INSR/ULK2/IRS2/MCU/TUBA4A/SLC39A14/FRAT1/PSMD3/ATG2B/CALML4/SLC25A31/RTN3/COX7A2L/SLC11A2/UQCRB/CHRM1/ATG2A/CASP8/TUBA1C/PIK3CD/PIK3CB/ULK1/WNT11	24
KEGG	hsa05168	Herpes simplex virus 1 infection	33/809	495/8135	0.9967	1	0.8583	HLA-DPB1/ZNF177/HLA-DOA/ZFP69/CD74/ZNF439/POU2F2/ZNF114/CCL2/PPP1CA/HLA-DRB1/CFP/IRAK1/ZNF814/TRAF3/ZNF135/EIF2AK4/CALR/BCL2L1/ZNF746/ZIK1/NECTIN2/ZNF569/ZNF614/CASP8/ZFP14/ZNF460/ZNF548/PIK3CD/C3/PDIA3/PIK3CB/ITGA5	33
KEGG	hsa00190	Oxidative phosphorylation	5/809	134/8135	0.9981	1	0.8583	COX15/ATP6V1C2/COX7A2L/UQCRB/ATP6V0D2	5
KEGG	hsa04080	Neuroactive ligand-receptor interaction	20/809	353/8135	0.9988	1	0.8583	P2RX1/PTGFR/FPR3/GALR3/HRH1/P2RY14/TRH/S1PR4/LEPR/PPY/NMB/CHRM1/LTB4R/P2RX7/CHRNB4/ADRB2/C3/FSHR/CYSLTR1/GLRA1	20
KEGG	hsa03010	Ribosome	4/809	158/8135	0.9999	1	0.8583	RPL7/RPL12/MRPL24/RPS24	4
KEGG	hsa04740	Olfactory transduction	9/809	440/8135	1	1	0.8583	OR3A3/ARRB2/GRK3/GRK2/RGS2/OR2L13/CALML4/PDE2A/SLC24A4	9